WorldWideScience

Sample records for bronchitis

  1. Bronchitis

    Science.gov (United States)

    ... How Can I Help a Friend Who Cuts? Bronchitis KidsHealth > For Teens > Bronchitis Print A A A ... Bronchitis Prevention en español La bronquitis What Is Bronchitis? Bronchitis (pronounced: brong-KYE-tis) is an inflammation ...

  2. Acute Bronchitis

    Science.gov (United States)

    ... of bronchitis: acute and chronic. Most cases of acute bronchitis get better within several days. But your cough ... that cause colds and the flu often cause acute bronchitis. These viruses spread through the air when people ...

  3. Chronic Bronchitis

    Science.gov (United States)

    Bronchitis is an inflammation of the bronchial tubes, the airways that carry air to your lungs. It ... chest tightness. There are two main types of bronchitis: acute and chronic. Chronic bronchitis is one type ...

  4. Acute Bronchitis

    Science.gov (United States)

    Bronchitis is an inflammation of the bronchial tubes, the airways that carry air to your lungs. It ... chest tightness. There are two main types of bronchitis: acute and chronic. Most cases of acute bronchitis ...

  5. Bronchitis - acute

    Science.gov (United States)

    ... sharing features on this page, please enable JavaScript. Acute bronchitis is swelling and inflammation in the main passages ... present only for a short time. Causes When acute bronchitis occurs, it almost always comes after having a ...

  6. Bronchitis - acute

    Science.gov (United States)

    Acute bronchitis is swelling and inflammation in the main passages that carry air to the lungs. The swelling narrows ... makes it harder to breathe. Another symptom of bronchitis is a cough. Acute means the symptoms have ...

  7. Plastic bronchitis

    Directory of Open Access Journals (Sweden)

    Anil Kumar Singhi

    2015-01-01

    Full Text Available Plastic bronchitis, a rare but serious clinical condition, commonly seen after Fontan surgeries in children, may be a manifestation of suboptimal adaptation to the cavopulmonary circulation with unfavorable hemodynamics. They are ominous with poor prognosis. Sometimes, infection or airway reactivity may provoke cast bronchitis as a two-step insult on a vulnerable vascular bed. In such instances, aggressive management leads to longer survival. This report of cast bronchitis discusses its current understanding.

  8. Plastic bronchitis

    OpenAIRE

    Anil Kumar Singhi; Bharathi Vinoth; Sarah Kuruvilla; Kothandam Sivakumar

    2015-01-01

    Plastic bronchitis, a rare but serious clinical condition, commonly seen after Fontan surgeries in children, may be a manifestation of suboptimal adaptation to the cavopulmonary circulation with unfavorable hemodynamics. They are ominous with poor prognosis. Sometimes, infection or airway reactivity may provoke cast bronchitis as a two-step insult on a vulnerable vascular bed. In such instances, aggressive management leads to longer survival. This report of cast bronchitis discusses its curre...

  9. What Causes Bronchitis?

    Science.gov (United States)

    ... page from the NHLBI on Twitter. What Causes Bronchitis? Acute Bronchitis Infections or lung irritants cause acute bronchitis. The ... fire, also may lead to acute bronchitis. Chronic Bronchitis Repeatedly breathing in fumes that irritate and damage ...

  10. Plastic Bronchitis

    OpenAIRE

    Quysner, Annie; Surani, Salim; Roberts, Daniel

    2011-01-01

    Plastic bronchitis is not yet well understood. There have been less than 500 reported cases in adults worldwide. This patient presented with a one month history of productive sputum consisting of bronchial casts resulting in a diagnosis of plastic bronchitis. [West J Emerg Med. 2011;12(1):118-119.

  11. Bronchitis (acute)

    OpenAIRE

    Wark, Peter

    2008-01-01

    Acute bronchitis, with transient inflammation of the trachea and major bronchi, affects over 40/1000 adults a year in the UK. The causes are usually considered to be infective, but only around half of people have identifiable pathogens.The role of smoking or environmental tobacco smoke inhalation in predisposing to acute bronchitis is unclear.A third of people may have longer-term symptoms or recurrence.

  12. Living with Chronic Bronchitis

    Science.gov (United States)

    ... from the NHLBI on Twitter. Living With Chronic Bronchitis If you have chronic bronchitis, you can take steps to control your symptoms. ... and a pneumonia vaccine. If you have chronic bronchitis, you may benefit from pulmonary rehabilitation (PR). PR ...

  13. Diagnosing and Treating Acute Bronchitis

    Science.gov (United States)

    ... Lung Disease Lookup > Acute Bronchitis Diagnosing and Treating Acute Bronchitis It is important to get your questions about ... Symptoms that last a few weeks How Is Acute Bronchitis Diagnosed? Healthcare providers diagnose acute bronchitis by asking ...

  14. How Is Bronchitis Treated?

    Science.gov (United States)

    ... symptoms and make breathing easier. If you have acute bronchitis, your doctor may recommend rest, plenty of fluids, ... treat fever. Antibiotics usually aren't prescribed for acute bronchitis. This is because they don't work against ...

  15. Heredity of chronic bronchitis

    DEFF Research Database (Denmark)

    Meteran, Howraman; Backer, Vibeke; Kyvik, Kirsten Ohm; Skytthe, Axel; Thomsen, Simon Francis

    2014-01-01

    BACKGROUND: Smoking is a major risk factor for lung diseases and lower respiratory symptoms, but since not all smokers develop chronic bronchitis and since chronic bronchitis is also diagnosed in never-smokers, it has been suggested that some individuals are more susceptible to develop chronic...... bronchitis due to genetics. OBJECTIVE: To study the relative influence of genetic and environmental factors on the variation in the susceptibility to chronic bronchitis. METHODS: In a population-based questionnaire study of 13,649 twins, 50-71 years of age, from the Danish Twin Registry, we calculated sex......-specific concordance rates and heritability of chronic bronchitis. The response rate was 75%. RESULTS: The prevalence of chronic bronchitis was 9.3% among men and 8.5% among women. The concordance rate for chronic bronchitis was higher in monozygotic twins than in dizygotic twins among women; 0.30 vs. 0.17, but not...

  16. Bronchitis and Pneumonia

    Science.gov (United States)

    ... What is the difference between bronchitis and pneumonia? Bronchitis is most often a bacte- rial or viral infection that causes swelling of the tubes (bronchioles) leading to the lungs. Pneumonia is an acute or chronic disease marked by inflammation of the ...

  17. Causes of acute bronchitis (image)

    Science.gov (United States)

    ... the respiratory system that leads into the lungs. Acute bronchitis has a sudden onset and usually appears after ... and the production of thick yellow mucus. If acute bronchitis occurs because of a bacterial infection antibiotics are ...

  18. Infectieuze bronchitis bij leghennen

    OpenAIRE

    Wit, de, S.

    1996-01-01

    Het Infectieuze Bronchitis Virus (IB) is een van de meest voorkomende virussen in de pluimveehouderij. Men mag rustig zeggen dat waar kippen gehouden worden, ook het IB virus voorkomt. Infecties met dit virus kunnen bij kippen van alle leeftijden ziekte m

  19. Clinical Features of Eosinophilic Bronchitis

    OpenAIRE

    Joo, Jae Hak; Park, Sang Joon; Park, Sung Woo; Lee, June Hyuk; Kim, Do Jin; Uh, Soo Taek; Kim, Yong Hoon; Park, Choon Sik

    2002-01-01

    Background Eosinophilic inflammation of the airway is usually associated with airway hyper-responsiveness in bronchial asthma. However, there is a small group of patients which has the eosinophilic inflammation in the bronchial tree with normal spirometry and no evidence of airway hyper-responsiveness, which was named eosinophilic bronchitis. The objectives of this study are 1) to investigate the incidence of eosinophilic bronchitis in the chronic cough syndrome and 2) to evaluate the clinica...

  20. What Are the Signs and Symptoms of Bronchitis?

    Science.gov (United States)

    ... What Are the Signs and Symptoms of Bronchitis? Acute Bronchitis Acute bronchitis caused by an infection usually develops after you ... nose, vomiting, and diarrhea. The main symptom of acute bronchitis is a persistent cough , which may last 10 ...

  1. Plastic Bronchitis in an Adult with Asthma

    OpenAIRE

    Kim, Eun Jin; Park, Jung Eun; Kim, Dong Hoon; Lee, Jaehee

    2012-01-01

    Plastic bronchitis is a rare disease characterized by marked airway obstruction, via the formation of large gelatinous or rigid airway cast. In Korea, there were a few case reports with plastic bronchitis not in adults, but in children. So we report a case of an adult who was diagnosed as plastic bronchitis with eosinophilic casts, with no history of atopic and cardiac disease.

  2. Get Smart: Know When Antibiotics Work - Bronchitis (Chest Cold)

    Science.gov (United States)

    ... Farm Get Smart About Antibiotics Week Bronchitis (Chest Cold) Language: English Español (Spanish) Recommend on Facebook Tweet ... types—acute bronchitis. Causes Acute bronchitis, or chest cold, often occurs after an upper respiratory infection like ...

  3. Chronic bronchitis in an elderly population

    DEFF Research Database (Denmark)

    Lange, Peter; Parner, Jan; Prescott, Eva;

    2003-01-01

    in order to describe the prevalence and prognostic implications of chronic bronchitis in individuals 65 years or older we analysed data from The Copenhagen City Heart Study.......in order to describe the prevalence and prognostic implications of chronic bronchitis in individuals 65 years or older we analysed data from The Copenhagen City Heart Study....

  4. Plastic bronchitis in beta thalassemia minor

    OpenAIRE

    Makaresh Yadav; Sneha Tirpude; Joshi, Jyotsna M.

    2013-01-01

    Plastic bronchitis is a rare pulmonary disorder associated with various conditions like cystic fibrosis, asthma, pulmonary infection and characterized by formation and expectoration of cast which assumes the shape of the bronchial tree. We report a case of a 33-year-old woman with beta thalassemia minor who developed plastic bronchitis.

  5. Acute Bronchitis - Multiple Languages: MedlinePlus

    Science.gov (United States)

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Acute Bronchitis URL of this page: https://medlineplus.gov/languages/acutebronchitis.html Other topics A-Z A B ...

  6. Molecular mechanisms of recurrent acute obstructive bronchitis in infants

    OpenAIRE

    Abaturov A.E.; Rusakova E.A.

    2015-01-01

    The article discusses the clinical and immunological features and mechanisms of recurrent acute obstructive bronchitis in infants. We have examined 102 children aged from 6 months to 3 years with acute obstructive bronchitis and signs of respiratory insufficiency of the I-II degree. There were 28 children with recurrent acute obstructive bronchitis and 74 patients with acute obstructive bronchitis,developed for the first time. We determined the concentration of total IgE, content of IFN-і, IL...

  7. 9 CFR 113.327 - Bronchitis Vaccine.

    Science.gov (United States)

    2010-01-01

    ... respiratory signs or death shall be counted as failures. Two-stage sequential testing may be conducted if the.... Final container samples of completed product shall be tested for virus titer using the procedure... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Bronchitis Vaccine. 113.327...

  8. Chronic Bronchitis - Multiple Languages: MedlinePlus

    Science.gov (United States)

    ... Somali) Bilingual PDF Health Information Translations Spanish (español) Bronquitis crónica Ukrainian (Українська) Bronchitis Бронхіт - Українська (Ukrainian) Bilingual ...

  9. Acute Bronchitis - Multiple Languages: MedlinePlus

    Science.gov (United States)

    ... Somali) Bilingual PDF Health Information Translations Spanish (español) Bronquitis aguda Ukrainian (Українська) Bronchitis Бронхіт - Українська (Ukrainian) Bilingual ...

  10. Heterotypic protection to infectious bronchitis virus

    Science.gov (United States)

    We developed Newcastle disease virus (NDV) LaSota (rLS) expressing a distinct spike (S) protein gene of infectious bronchitis virus (IBV). This recombinant vaccine technology confers cross-protection among different IBV strains. We also experimentally demonstrated that the recombinant construct main...

  11. Comprehensive diagnosis and treatment of patients with deforming bronchitis

    International Nuclear Information System (INIS)

    A total of 1067 patients aged from 15 to 82 years who suffered from deforming bronchitis were examined. All the patients underwent X-ray examination, forced external respiration test, bronchofibroscopy with biopsy and radionuclide study of the lungs whose results were the basis for establishing a diagnosis of deforming bronchitis with an accuracy of 99,8%. Therapeutical bronchoscopies made in patients with deforming bronchitis were an effective therapeutical tool in 96,9-98,1% of cases

  12. Infectious Bronchitis Vaccination Protocols for Laying Hens

    OpenAIRE

    A. Sulaiman; Roberts, J.R.

    2011-01-01

    A research was conducted to investigate the effects of vaccination protocols for Infectious Bronchitis (IB) on egg production, egg quality, and IB antibody titres of laying hens. Different initial vaccination (Control, VicS eye, VicS spray, VicS water, A3 eye, A3 spray, and A3 water) for IB were administered to day-old Isa Brown hens. Half the hens were revaccinated regularly during lay whereas the other hens were not vaccinated. Results showed that initial vaccination treatment had signific...

  13. Mucociliary clearance in early simple chronic bronchitis

    International Nuclear Information System (INIS)

    Tracheobronchial mucociliary clearance was measured in 37 patients with early simple chronic bronchitis. A non-invasive radio-aerosol technique with inhalation of 99Tcm labelled 5-μm polystyrene particles followed by assessment of radio-nuclide distribution by posterior gamma-camera scans was employed. The mucociliary clearance of the bronchitics was significantly slower than clearance of a non-smoker control group. An interim analysis of the effect of treatment with a surfactant stimulating drug, ambroxol, suggested a dosage-dependent tendency to a faster mucociliary clearance than seen in placebo-treated bronchitics. (author)

  14. Radioisotope hepatography in patients with chronic bronchitis

    International Nuclear Information System (INIS)

    Examination carried out by means of radioisotope hepatography with bengal-rose-iodine 131 in 69 patients with chronic obstructive bronchitis associated with respiratory insufficiency of grades 1, 2, 3 at the phase of remission revealed disturbances of the absorptive-excretory function of the liver. A direct dependence was found between the intensity of disorder of the functionsl state of parenchymatous cells and degree of resperatory insufficiency in this category of patients. The disorders of the absorptive-excretory function of the liver were most pronounced in respiratory insufficiency of grade 3

  15. Plastic Bronchitis in a Child Presenting as Surgical Emphysema

    Directory of Open Access Journals (Sweden)

    Nikita Tripathi

    2015-12-01

    Full Text Available Plastic bronchitis (PB refers to the presence of inspissated Bronchial casts (BC is uncommon in children.Our case presented with subcutaneous emphysema as the dominant manifestation and was suspected to have foreign body in airway, but bronchoscopy revealed a bronchial cast. Subcutaneous emphysema as the initial/sole manifestation of plastic bronchitis is very rare in children.

  16. Bronchial inflammation in chronic bronchitis assessed by measurement of cell products in bronchial lavage fluid.

    OpenAIRE

    Riise, G. C.; Ahlstedt, S.; Larsson, S.; Enander, I.; Jones, I; Larsson, P.; Andersson, B

    1995-01-01

    BACKGROUND--Bronchial inflammation in chronic bronchitis has not been characterised as well as in asthma. The present study was undertaken to assess whether a characteristic pattern of bronchial inflammatory markers could be found in patients with chronic bronchitis. METHODS--Bronchoscopy with bronchial lavage was performed in 42 patients with chronic bronchitis and in 13 healthy controls. Twenty three of the patients had non-obstructive chronic bronchitis and 19 had chronic bronchitis and ch...

  17. Risk of chronic bronchitis in twin pairs discordant for smoking

    DEFF Research Database (Denmark)

    Meteran, Howraman; Thomsen, Simon Francis; Harmsen, Lotte;

    2012-01-01

    It is well known that smoking is a major risk factor for lung disease and respiratory symptoms. We examined the association between smoking and the risk of chronic bronchitis in a large twin sample....

  18. Chronic Obstructive Pulmonary Disease (COPD) Includes: Chronic Bronchitis and Emphysema

    Science.gov (United States)

    ... Obstructive Pulmonary Disease (COPD) Includes: Chronic Bronchitis and Emphysema Recommend on Facebook Tweet Share Compartir Data are ... of adults who have ever been diagnosed with emphysema: 3.4 million Percent of adults who have ...

  19. Comparison of airway immunopathology of eosinophilic bronchitis and asthma

    OpenAIRE

    Brightling, C.; Symon, F; Birring, S; Bradding, P; Wardlaw, A; PAVORD, I

    2003-01-01

    Methods: Exhaled nitric oxide was measured and induced sputum, bronchoscopy, bronchial wash (BW), bronchoalveolar lavage (BAL), and bronchial biopsy were performed in 16 subjects with eosinophilic bronchitis, 15 with asthma, and 14 normal controls.

  20. Hydrator Therapies for Chronic Bronchitis. Lessons from Cystic Fibrosis.

    Science.gov (United States)

    Bennett, William D; Henderson, Ashley G; Donaldson, Scott H

    2016-04-01

    Patients with the chronic bronchitis form of chronic obstructive pulmonary disease and cystic fibrosis share similar clinical features, including mucus obstruction of airways and the development of chronic/recurrent airways infections that often manifest as disease exacerbations. There is growing evidence that these diseases may have parallels in disease pathogenesis as well, including cystic fibrosis transmembrane conductance regulator dysfunction, mucus dehydration, and defective mucociliary clearance. As progress is made in the development of therapies that target the basic defects that lead to cystic fibrosis lung disease, it is possible that similar approaches could also benefit patients with chronic bronchitis. A deeper understanding of how tobacco smoke and other triggers of chronic bronchitis actually lead to disease, and exploration of the concept that therapies that restore cystic fibrosis transmembrane conductance regulator function, mucus hydration, and/or mucociliary clearance may benefit patients with chronic bronchitis, hold the prospect of significant progress in treating this prevalent disease. PMID:27115955

  1. Molecular mechanisms of recurrent acute obstructive bronchitis in infants

    Directory of Open Access Journals (Sweden)

    Abaturov A.E.

    2015-06-01

    Full Text Available The article discusses the clinical and immunological features and mechanisms of recurrent acute obstructive bronchitis in infants. We have examined 102 children aged from 6 months to 3 years with acute obstructive bronchitis and signs of respiratory insufficiency of the I-II degree. There were 28 children with recurrent acute obstructive bronchitis and 74 patients with acute obstructive bronchitis,developed for the first time. We determined the concentration of total IgE, content of IFN-і, IL-4, IL-12 and IL-13 in serum by ELISA and the expression of the transcription factor NF-єB in lymphocytes of peripheral blood by flow cytometry in all the children. High level of IL-12 as compared to physiological norms in the dynamics of the disease was the characteristic feature of the children of both groups. And it was the factor, which detected a voltage of cell-mediated immune response and inflammation. The second specific feature was the high concentration of IgE. It was shown that the transcription factor NF-єB determined the cytokine status at the beginning of the disease, and in the period of convalescence. That fact did not depend on the number of previous acute obstructive bronchitis. However, there were violations of the mechanisms of NF-єB-associated signaling pathways activation, which manifested itself in an advantageous enhancement of the chains, determining the production of Th2-associated cytokines in children with recurrent acute obstructive bronchitis.

  2. Infectious Bronchitis Vaccination Protocols for Laying Hens

    Directory of Open Access Journals (Sweden)

    A. Sulaiman

    2011-12-01

    Full Text Available A research was conducted to investigate the effects of vaccination protocols for Infectious Bronchitis (IB on egg production, egg quality, and IB antibody titres of laying hens. Different initial vaccination (Control, VicS eye, VicS spray, VicS water, A3 eye, A3 spray, and A3 water for IB were administered to day-old Isa Brown hens. Half the hens were revaccinated regularly during lay whereas the other hens were not vaccinated. Results showed that initial vaccination treatment had significant effects on hen day egg production and egg quality of egg weight, shell reflectivity, shell breaking strength, shell thickness, albumen height, Haugh Units, and IB antibody titre levels, but had no effect on percentage of shell and yolk colour. Egg weight and shell reflectivity were less favourable in the control hens. In contrast, shell breaking strength and shell thickness were highest for the group that initially received A3 vaccine in water. However, regular revaccination had some deleterious effects on egg production and egg quality. There were no significant effects of revaccination on IB antibody titres. It is concluded that there was little advantage in regularly revaccinating laying hens for IB virus, since they had received appropriate initial vaccination.

  3. Etiology and immunology of infectious bronchitis virus

    Directory of Open Access Journals (Sweden)

    LF Caron

    2010-06-01

    Full Text Available Infectious bronchitis virus (IBV of chickens is currently one of the main diseases associated with respiratory syndrome in domestic poultry, as well as with losses related to egg production. The etiological agent is a coronavirus, which presents structural differences in the field, mainly in the S1 spike protein. The immune response against this virus is complicated by the few similarities among serotypes. Environmental and management factors, as well as the high mutation rate of the virus, render it difficult to control the disease and compromise the efficacy of the available vaccines. Bird immune system capacity to respond to challenges depend on the integrity of the mucosae, as an innate compartment, and on the generation of humoral and cell-mediated adaptive responses, and may affect the health status of breeding stocks in the medium run. Vaccination of day-old chicks in the hatchery on aims at eliciting immune responses, particularly cell-mediated responses that are essential when birds are first challenged. Humoral response (IgY and IgA are also important for virus clearance in subsequent challenges. The presence of antibodies against the S1 spike protein in 3- to 4-week-old birds is important both in broilers and for immunological memory in layers and breeders.

  4. Anti-inflammatory drugs and experimental bronchitis.

    Science.gov (United States)

    Jeffery, P K

    1986-01-01

    Chronic bronchitis (chronic hypersecretion) and chronic bronchiolitis (small airways disease) are two conditions associated with cigarette smoking: both contribute to airflow obstruction in man, the latter associated with progressive deterioration in lung function. Mucous metaplasia and hyperplasia are characteristic histological changes. Experimentally, cigarette smoke given daily for two weeks, induces similar histological changes in the airways of specific pathogen-free rats, providing a suitable animal model for study: an early proliferation of basal cells, accompanied by mucous metaplasia of surface epithelial serous cells is followed by proliferation of newly formed mucous cells. There is also a significant increase in epithelial thickness due to cell hypertrophy without stratification or prior ulceration. Experimentally, secretory cell hyperplasia is inhibited completely or to varying degrees by prophylactic administration (intraperitoneal injection) of either indomethacin, flurbiprofen, dexamethasone, prednisolone, hydrocortisone (each at 2 or 4 mg/kg body weight) or a mucolytic drug, N-acetylcysteine(Nac), given orally as a 1% solution of the drinking water. Nac also inhibits the associated mucus-hypersecretion. It takes between 21 and 84 days, depending on airway level, for the increase in secretory cell number to return to control values (ie recover). Indomethacin and flurbiprofen (4 mg/kg, by ip injection) shorten recovery to between 4 and 9 days in intrapulmonary airways but have no effect on recovery time in the rat trachea. Nac is effective in 6 of 7 airway levels which showed cigarette smoke-induced mucous cell hyperplasia. In conclusion, in the rat, the response to cigarette smoke is one of mucous cell metaplasia and both basal and mucous cell proliferation. Cigarette smoke-induced mucous cell hyperplasia can be inhibited when selected drugs are given concurrently with the cigarette smoke: indomethacin, fluriprofen and Nac are also therapeutic

  5. Features of Chronic Bronchitis in Different Age Groups

    Directory of Open Access Journals (Sweden)

    Galina L. Ignatova

    2014-03-01

    Full Text Available Background: Lung diseases are assuming greater relevance and importance today. Chronic bronchitis is a self-nosology, which may precede the development of COPD, the importance of which can hardly be overestimated. The main problem in this disease is caused by late diagnosis and treatment due to the delay by patients in seeking medical help. The aim of the work was to study the distribution and exposure to tobacco smoke, especially chronic bronchitis, depending on various factors, including age. Methods: We examined 1779 persons, including 855 men and 924 women. The mean age of the population was 35.83±8.3 years. We conducted surveys and spirometry. The outcome was assessed after a bronchodilation test was performed with salbutamol 400 mcg. We performed all statistical analysis using software package Statistica 10. Results: We identified chronic bronchitis in 9.2% of the cases in the group of younger individuals and in 14.9% of the cases in the group of older individuals, during the active detection of chronic bronchitis using questionnaires. The prevalence of cigarette smoking was slightly higher among the younger (39.5% than the older persons (33.6%; the frequency of smoking in a group of chronic bronchitis was reliably higher. Also, in this group, the performance spirometry reliably decreased. Conclusions: Outpatient survey is an effective method of identifying chronic bronchitis. Smoking is a major risk factor in the group of young respondents and the prevalence of smoking is inversely related to the education level of the respondents, regardless of age. As the decline in the Forced Expiratory Volume (FEV1 and FEV1/FVC is the main criterion diagnosis of COPD, it revealed significant declines in the FEV1 of the younger smoking individuals, which may help to predict the development of COPD in the older age group.

  6. Cerebral Lipiodol Embolism after Lymphatic Embolization for Plastic Bronchitis.

    Science.gov (United States)

    Kirschen, Matthew P; Dori, Yoav; Itkin, Maxim; Licht, Daniel J; Ichord, Rebecca; Vossough, Arastoo

    2016-09-01

    An adolescent with plastic bronchitis due to congenital heart disease had altered mental status after an interventional lymphatic procedure in which lipiodol contrast was used. Neuroimaging revealed cerebral lipiodol embolization due to direct shunting between lymphatic channels and pulmonary veins. Cerebral lipiodol embolization is a potential neurologic morbidity associated with interventional lymphatic procedures. PMID:27297208

  7. PULMONARY FUNCTION ADAPTATION TO OZONE IN SUBJECTS WITH CHRONIC BRONCHITIS

    Science.gov (United States)

    Twenty smokers with chronic bronchitis were exposed to 0.41 ppm ozone for 3 hr-day for 5 consecutive days and reexposed 4 days later to determine (1) if they are sensitive to ozone, (2) if they adapt, and (3) if the adaptation lasts longer than 4 days. There were significant decr...

  8. Avian infectious bronchitis virus in Africa: a review.

    Science.gov (United States)

    Khataby, Khadija; Fellahi, Siham; Loutfi, Chafiqa; Mustapha, Ennaji Moulay

    2016-06-01

    Infectious bronchitis virus (IBV) is worldwide in distribution, highly infectious, and extremely difficult to control because it has extensive genetic diversity, a short generation time, and a high mutation rate. IBV is a Gammacoronavirus, single-stranded, and positive-sense RNA virus. Avian infectious bronchitis is well studied in European countries with identification of a large number of IBV variants, whereas in African countries epidemiological and scientific data are poor and not updated. However, previous studies reported that an IBV variant continues to appear regularly in Africa, as currently described in Morocco. No cross-protection between IBV strains was reported, some being unique to a particular country, others having a more general distribution. This review aims to provide a general overview on IB disease distribution in African countries and an update on the available studies of IBV variants in each country. PMID:27150555

  9. Role of PGE2 in Asthma and Nonasthmatic Eosinophilic Bronchitis

    OpenAIRE

    Beatriz Sastre; Victoria del Pozo

    2012-01-01

    Eosinophilic bronchitis is a common cause of chronic cough, which like asthma is characterized by sputum eosinophilia, but unlike asthma there is no variable airflow obstruction or airway hyperresponsiveness. Several studies suggest that prostaglandins may play an important role in orchestrating interactions between different cells in several inflammatory diseases such as asthma. PGE2 is important because of the multiplicity of its effects on immune response in respiratory diseases; however, ...

  10. Oral Fluoroquinolones in the Treatment of Pneumonia, Bronchitis and Sinusitis

    OpenAIRE

    Mittmann, Nicole; Jivraj, Farah; Wong, Angelina; Yoon, Alice

    2002-01-01

    BACKGROUND: Despite a relatively large number of clinical studies comparing oral fluoroquinolones to one antibiotic class comparator, there is limited information on the relative efficacy of different fluoroquinolones.OBJECTIVE: To examine the efficacy and tolerability of oral fluoroquinolones in the treatment of mild to moderate community-acquired pneumonia, acute exacerbations of chronic bronchitis and sinusitis.METHODS: A systematic review was undertaken with a MEDLINE search for antibioti...

  11. Carbon monoxide and exercise tolerance in chronic bronchitis and emphysema.

    OpenAIRE

    Calverley, P. M.; Leggett, R J; Flenley, D C

    1981-01-01

    The effects of carbon monoxide on exercise tolerance as assessed by the distance walked in 12 minutes were studied in 15 patients with severe chronic bronchitis and emphysema (mean forced expiratory volume in one second 0.56 1, mean forced vital capacity 1.54 1). Each subject walked breathing air and oxygen before and after exposure to sufficient carbon monoxide to raise their venous carboxyhaemoglobin concentration by 9%. There was a significant reduction in the walking distance when the pat...

  12. Controlled trial of supervised exercise training in chronic bronchitis.

    OpenAIRE

    D. J. Sinclair; Ingram, C G

    1980-01-01

    In a controlled trial of exercise retraining in patients with severe chronic bronchitis, 33 subjects were followed for a mean period of 10.3 months. The exercise programme was supervised once a week, and daily training comprised a 12-minute walk and simple stair climbing exercises. The subjects in the exercise group showed a highly significant improvement in their walking distance, attaining a maximum increase of 24% after eight to 12 months. There was also considerable subjective improvement...

  13. Canine chronic bronchitis: a pathophysiologic evaluation of 18 cases

    International Nuclear Information System (INIS)

    Eighteen dogs with chronic bronchitis were studied using physiologic, radiologic, microbiologic, and pathologic techniques. Twelve of these dogs were evaluated before and after two weeks of oral bronchodilator administration. Thoracic radiographs, tidal breathing flow-volume loops, radioaerosol ventilation scans, airway appearance at bronchoscopy, and airway pathology were abnormal in the majority of dogs studied. There was a significant relationship between abnormal ventilation scans and abnormal results for PaO2 and end-tidal airflow. Bronchoscopy revealed excessive mucus and inflammation of airway mucosa in all 16 dogs undergoing this procedure. Endoscopically obtained aerobic bacterial cultures grew mixed bacterial flora in only three dogs. Increased numbers of neutrophils in 14 dogs were detected by airway lavage cytology. A large number of eosinophils were seen in airway lavages obtained from two dogs; these two dogs also had evidence for eosinophilic bronchitis on endobronchial biopsy. Oral bronchodilator administration resulted in clinical and expiratory airflow improvements in most dogs, but had no effect on PaO2 or on the radioaerosol-scan abnormalities. The presence of both the physiologic and pathologic airway abnormalities of chronic bronchitis in dogs presented to a veterinary hospital with chronic unexplained cough was confirmed, suggesting that aerobic bacteria do not play an etiologic role in most cases

  14. [Chronic bronchitis and its sequelae. Therapy--prognosis--insurance medicine aspects].

    Science.gov (United States)

    Gillissen, A; Schmidt, E W

    1996-12-01

    Chronic bronchitis is of enormous epidemiological, socio-medical and economical importance. The main cause of chronic bronchitis is active but also passive cigarette smoking. Other etiologic factors are: viral or bacterial infections, chronic dust exposure in occupational settings and air pollution. Cease of cigarette smoking is considered the most valuable action in the treatment of the chronic bronchitis. In addition to drug therapy, physical therapy and other measures of rehabilitation may be a supportive benefit. ABout 10-20% of all patients with chronic bronchitis develop airway obstruction and/or lung emphysema. Obstructive bronchitis with or without lung emphysema should be treated with corticosteroids, beta 2-agonists and/or theophylline. Evidence for the socio-economical burden of chronic bronchitis and its complications are the enormous costs for the social economy (direct costs: in- and outpatient treatment; indirect costs: premature pensions, sick leave). PMID:9082644

  15. Dyspnea and Wheezing after Adenosine Injection in a Patient with Eosinophilic Bronchitis

    OpenAIRE

    Kaiser Lim; Marie Christine Aubry; Rodrigo Cartin-Ceba

    2009-01-01

    A 58-year-old nonsmoker female was referred for evaluation of chronic cough of 13 months duration. After an initial work-up, the patient was diagnosed to have chronic cough due to eosinophilic bronchitis. The diagnostic work-up for eosinophilic bronchitis and bronchial biopsy is discussed. Eosinophilic bronchitis is differentiated from asthma. In addition, the patient developed dyspnea, flushing, and wheezing after the administration of adenosine during a cardiac stress test in spite of a neg...

  16. Cystic fibrosis transmembrane conductance regulator gene abnormalities in patients with asthma and recurrent neutrophilic bronchitis

    OpenAIRE

    Jodi Goodwin; Naomi Spitale; Asma Yaghi; Myrna Dolovich; Parameswaran Nair

    2012-01-01

    The present case series describes four patients with asthma, airway hyper-responsiveness and neutrophilic bronchitis who harboured abnormal cystic fibrosis transmembrance conductance regulator (CFTR) gene mutations. It serves both to alert clinicians to consider CFTR-related disease in both young and elderly patients with persistent neutrophilic bronchitis, and to highlight the potential utility of future genetic testing for CFTR abnormalities in patients with asthma and recurrent bronchitis ...

  17. Relation between Ascites Syndrome Incidence and Infectious Bronchitis in Broiler Chickens by ELISA Method

    OpenAIRE

    Adel Feizi; Mehrdad Nazeri

    2011-01-01

    Infectious bronchitis is an acute viral disease with high contagious and mortality among chicks. The aim of this study was to survey of relation between ascites syndrome incidence and infectious bronchitis in broiler chickens by ELISA method in Iran. Eight Ross strain broiler farm affected by infectious bronchitis were selected in this study. Blood samples were gathered early stages of disease and blood sampling was repeated two times with seven days interval. ELISA serologic test was used fo...

  18. Clinical efficacy of Vyaghriharitaki Avaleha in the management of chronic bronchitis

    OpenAIRE

    Ram, Jaiprakash; Baghel, Madhav Singh

    2015-01-01

    Introduction: Vyaghriharitaki Avaleha (VHA), a polyherbal classical Ayurvedic formulation has been used in Kasa (cough), Swasa (asthma), Rajayakshma (tuberculosis) etc., conditions. Aim: To evaluate the clinical efficacy of VHA in the management of chronic bronchitis. Materials and Methods: Patients of chronic bronchitis were given 10 g of VHA twice a day with lukewarm water before meals for 12 weeks. Improvement in clinical symptoms of chronic bronchitis as the primary outcome measures and S...

  19. Avian infectious bronchitis virus in Brazil: a highly complex virus meets a highly susceptible host population

    Directory of Open Access Journals (Sweden)

    PE Brandão

    2010-06-01

    Full Text Available Infectious bronchitis (IB is a highly aggressive disease for poultry in terms of symptoms and economic losses, and the control of this disease is difficult if flocks are not protected against type-specific challenges by the Avian infectious bronchitis virus (IBV. This article summarizes data presented by the author at the Workshop on Infectious Bronchitis 2009 on IB and IBV, including future developments on the field.

  20. Childhood respiratory infection and adult chronic bronchitis in England and Wales.

    OpenAIRE

    Barker, D J P; Osmond, Clive

    1986-01-01

    The high mortality from chronic bronchitis in England and Wales and the excess of urban over rural mortality are unexplained. On dividing England and Wales into 212 local authority areas a strong geographical relation was found between death rates from chronic bronchitis and emphysema in 1959-78 and infant mortality from bronchitis and pneumonia during 1921-5. It was concluded that this relation provided strong evidence of a direct casual link between acute lower respiratory infection in earl...

  1. Measurement of tracheobronchial clearance after sauna in subjects with chronic bronchitis.

    OpenAIRE

    van Hengstum, M; Festen, J.; Corstens, F.

    1991-01-01

    The effect of sauna on tracheobronchial clearance was studied in five male patients with chronic bronchitis by a radioaerosol technique. No enhancement of tracheobronchial clearance could be detected.

  2. Assessment of the accuracy of thoracic radiography in the diagnosis of canine chronic bronchitis

    International Nuclear Information System (INIS)

    Thoracic radiographs from 23 dogs with chronic bronchitis were mixed with those taken from 11 dogs (matched by age and bodyweight) without respiratory disease and interpreted twice by two blinded, independent examiners in an attempt to determine the accuracy of radiography for the diagnosis of chronic bronchitis. The only radiographic signs found more often in dogs with chronic bronchitis were thickening of the bronchial walls and increased numbers of visible bronchial walls (P 0.64). The accuracy of radiographic diagnosis of chronic bronchitis is limited principally by insensitivity for bronchial lesions

  3. E Protein Prokaryotic Expression of Avian Infectious Bronchitis Virus

    Institute of Scientific and Technical Information of China (English)

    WEI Ping; ZHANG Fang; MING Xiaobo; ZENG Xiangwei; ZHU Yuqing; WANG Lin

    2008-01-01

    The small envelope protein (E) gene of avian infectious bronchitis virus (IBV) M41 strain was cloned,and then it was subeloned into prokaryotic expressing vector pGEX-6P-1.The recombinant plasmid was transformed into E.coli.BL21 and induced by IPTG.SDS-PAGE result showed that when objective protein fused with GST (about 20 ku), the relative molecular mass of fusion protein was 38 ku.It indicated that objective protein was about 12.4 ku.The result showed that E protein was expressed successfully, it was useful to the subsequent E protein research.

  4. Factors affecting the decline of ventilatory function in chronic bronchitis.

    OpenAIRE

    Campbell, A H; Barter, C. E.; O'Connell, J M; Huggins, R

    1985-01-01

    Ninety six middle aged male patients with chronic bronchitis with relatively well preserved ventilatory function who were resident in Queensland, New South Wales, or Victoria took part in a prospective study to determine the relationship of various factors to the rate of decline of the FEV1. Thirty of the subjects withdrew, leaving 66 to be followed for four to six years. The mean rate of decline of the FEV1 was 58.6 (SD 51.4) ml/year. The subjects' ventilatory responses to bronchodilator and...

  5. Atopy: a predisposing factor for chronic bronchitis in Finland.

    OpenAIRE

    Terho, E O; Koskenvuo, M.; Kaprio, J

    1995-01-01

    STUDY OBJECTIVE--To investigate the predictive value of atopy, smoking, and living in a farm environment in the development of chronic bronchitis. DESIGN--This was a cross sectional and longitudinal study. SETTING--Postal surveys carried out in Finland in 1975 and 1981. PARTICIPANTS--The study was part of the Finnish twin cohort study, which included adult twin pairs born in Finland before 1958. The cross sectional sample consisted of 18,351 subjects, including 1025 prevalent cases, and the f...

  6. Recurrent Plastic Bronchitis in a Child with 2009 Influenza A (H1N1) and Influenza B Virus Infection

    OpenAIRE

    Kim, Sun; Cho, Hwa Jin; Han, Dong Kyun; Choi, Yoo Duk; Yang, Eun Seok; Cho, Young Kuk; Ma, Jae Sook

    2012-01-01

    Plastic bronchitis is an uncommon disorder characterized by the formation of bronchial casts. It is associated with congenital heart disease or pulmonary disease. In children with underlying conditions such as allergy or asthma, influenza can cause severe plastic bronchitis resulting in respiratory failure. A review of the literature showed nine cases of plastic bronchitis with H1N1 including this case. We report a case of a child with recurrent plastic bronchitis with eosinophilic cast assoc...

  7. 77 FR 59929 - Guidance for Industry on Acute Bacterial Exacerbations of Chronic Bronchitis in Patients With...

    Science.gov (United States)

    2012-10-01

    ... August 22, 2008 (73 FR 49684), which in turn revised the draft guidance for industry entitled ``Acute... ``Acute Bacterial Exacerbations of Chronic Bronchitis in Patients With Chronic Obstructive Pulmonary... treatment of acute bacterial exacerbations of chronic bronchitis in patients with chronic...

  8. Barotrauma as aetiological cascade of fatal intrapulmonary plastic bronchitis in a post-Fontan child

    OpenAIRE

    Elahi, Maqsood; Poh, Chin-Leng; Ravindranathan, Hari; Grant, Peter

    2012-01-01

    The role of barotrauma in the exaggeration of plastic bronchitis after Fontan circulation has yet to be examined. We aim to describe a case of a 4-year old post-Fontan circulation girl where barotrauma suffered during commercial air travel played a role in the aetiological cascade of plastic bronchitis.

  9. The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma

    OpenAIRE

    Nair Parameswaran; Ochkur Sergei I; Protheroe Cheryl; Simms Elizabeth; Lee Nancy A; Lee James J

    2011-01-01

    Abstract This case reports the unique association of eosinophilic gastrointestinal disease with eosinophilic bronchitis, asthma and chronic rhinosinusitis and some features of lymphocytic hypereosinophilic syndrome, describes a diagnostic protocol for patients with asthma and persistent eosinophilic bronchitis, and suggests that the use of a novel EPX-mAb provides a reliable method to identify eosinophilic inflammation.

  10. Role of PGE2 in Asthma and Nonasthmatic Eosinophilic Bronchitis

    Directory of Open Access Journals (Sweden)

    Beatriz Sastre

    2012-01-01

    Full Text Available Eosinophilic bronchitis is a common cause of chronic cough, which like asthma is characterized by sputum eosinophilia, but unlike asthma there is no variable airflow obstruction or airway hyperresponsiveness. Several studies suggest that prostaglandins may play an important role in orchestrating interactions between different cells in several inflammatory diseases such as asthma. PGE2 is important because of the multiplicity of its effects on immune response in respiratory diseases; however, respiratory system appears to be unique in that PGE2 has beneficial effects. We described that the difference in airway function observed in patients with eosinophilic bronchitis and asthma could be due to differences in PGE2 production. PGE2 present in induced sputum supernatant from NAEB patients decreases BSMC proliferation, probably due to simultaneous stimulation of EP2 and EP4 receptors with inhibitory activity. This protective effect of PGE2 may not only be the result of a direct action exerted on airway smooth-muscle proliferation but may also be attributable to the other anti-inflammatory actions.

  11. Pathogenesis and Diagnostic Approaches of Avian Infectious Bronchitis

    Directory of Open Access Journals (Sweden)

    Faruku Bande

    2016-01-01

    Full Text Available Infectious bronchitis (IB is one of the major economically important poultry diseases distributed worldwide. It is caused by infectious bronchitis virus (IBV and affects both galliform and nongalliform birds. Its economic impact includes decreased egg production and poor egg quality in layers, stunted growth, poor carcass weight, and mortality in broiler chickens. Although primarily affecting the respiratory tract, IBV demonstrates a wide range of tissues tropism, including the renal and reproductive systems. Thus, disease outcome may be influenced by the organ or tissue involved as well as pathotypes or strain of the infecting virus. Knowledge on the epidemiology of the prevalent IBV strains in a particular region is therefore important to guide control and preventions. Meanwhile previous diagnostic methods such as serology and virus isolations are less sensitive and time consuming, respectively; current methods, such as reverse transcription polymerase chain reaction (RT-PCR, Restriction Fragment Length Polymorphism (RFLP, and sequencing, offer highly sensitive, rapid, and accurate diagnostic results, thus enabling the genotyping of new viral strains within the shortest possible time. This review discusses aspects on pathogenesis and diagnostic methods for IBV infection.

  12. Preliminary crystallographic analysis of avian infectious bronchitis virus main protease

    International Nuclear Information System (INIS)

    The avian infectious bronchitis virus main protease has been crystallized; crystals diffract to 2.7 Å resolution. Infectious bronchitis virus (IBV) is the prototype of the genus Coronavirus. It causes a highly contagious disease which affects the respiratory, reproductive, neurological and renal systems of chickens, resulting great economic losses in the poultry industry worldwide. The coronavirus (CoV) main protease (Mpro), which plays a pivotal role in viral gene expression and replication through a highly complex cascade involving the proteolytic processing of replicase polyproteins, is an attractive target for antiviral drug design. In this study, IBV Mpro was overexpressed in Escherichia coli. Crystals suitable for X-ray crystallography have been obtained using microseeding techniques and belong to space group P6122. X-ray diffraction data were collected in-house to 2.7 Å resolution from a single crystal. The unit-cell parameters were a = b = 119.1, c = 270.7 Å, α = β = 90, γ = 120°. Three molecules were predicted to be present in the asymmetric unit from a calculated self-rotation function

  13. Relation between Ascites Syndrome Incidence and Infectious Bronchitis in Broiler Chickens by ELISA Method

    Directory of Open Access Journals (Sweden)

    Adel Feizi

    2011-12-01

    Full Text Available Infectious bronchitis is an acute viral disease with high contagious and mortality among chicks. The aim of this study was to survey of relation between ascites syndrome incidence and infectious bronchitis in broiler chickens by ELISA method in Iran. Eight Ross strain broiler farm affected by infectious bronchitis were selected in this study. Blood samples were gathered early stages of disease and blood sampling was repeated two times with seven days interval. ELISA serologic test was used for approving the determination of infectious bronchitis. In addition, in order to differential diagnosis of Newcastle and influenza (H9N2 some relevant experiments were conducted. The rate of mortality in any farm during rearing, autopsy and the cause of mortality were recorded. Ascites cases were calculated in terms of prevalence. The growth parameters, FCR, final weight, total consumption of grain at each farm were calculated and mentioned. Based on obtained results in this study, the mean rate of mortality caused by ascites syndrome has been increased meaningfully in herds affected by infectious bronchitis compared with control group. In eight understudied farms affected by infectious bronchitis, the mean rate of Ascites mortality was 3% such that the mean rate of Ascites mortality was 0.5% at previous periods. Based on relevant results also final weight mean in affected herds with infectious bronchitis was lower compared with previous periods. Meanwhile, FCR in affected herds with infectious bronchitis was high compared with healthy herds. In this research demonstrated that there is positive correlation between infectious bronchitis and Ascites syndrome and the correlation is significant (p<0.05.

  14. Recombinant duck enteritis viruses expressing major structural proteins of the infectious bronchitis virus provide protection against infectious bronchitis in chickens.

    Science.gov (United States)

    Li, Huixin; Wang, Yulong; Han, Zongxi; Wang, Yu; Liang, Shulin; Jiang, Lu; Hu, Yonghao; Kong, Xiangang; Liu, Shengwang

    2016-06-01

    To design an alternative vaccine for control of infectious bronchitis in chickens, three recombinant duck enteritis viruses (rDEVs) expressing the N, S, or S1 protein of infectious bronchitis virus (IBV) were constructed using conventional homologous recombination methods, and were designated as rDEV-N, rDEV-S, and rDEV-S1, respectively. Chickens were divided into five vaccinated groups, which were each immunized with one of the rDEVs, covalent vaccination with rDEV-N & rDEV-S, or covalent vaccination with rDEV-N & rDEV-S1, and a control group. An antibody response against IBV was detectable and the ratio of CD4(+)/CD8(+) T-lymphocytes decreased at 7 days post-vaccination in each vaccinated group, suggesting that humoral and cellular responses were elicited in each group as early as 7 days post-immunization. After challenge with a homologous virulent IBV strain at 21 days post-immunization, vaccinated groups showed significant differences in the percentage of birds with clinical signs, as compared to the control group (p < 0.01), as the two covalent-vaccination groups and the rDEV-S group provided better protection than the rDEV-N- or rDEV-S1-vaccinated group. There was less viral shedding in the rDEV-N & rDEV-S- (2/10) and rDEV-N & rDEV-S1- (2/10) vaccinated groups than the other three vaccinated groups. Based on the clinical signs, viral shedding, and mortality rates, rDEV-N & rDEV-S1 covalent vaccination conferred better protection than use of any of the single rDEVs. PMID:26946113

  15. Crystallization and preliminary X-ray diffraction studies of infectious bronchitis virus nonstructural protein 9

    OpenAIRE

    Ma, Yanlin; Chen, Cheng; Wei, Lei; Yang, Qingzhu; Liao, Ming; Li, Xuemei

    2010-01-01

    The gene segment encoding avian infectious bronchitis virus nonstructural protein 9 has been cloned and expressed in Escherichia coli. The protein has been crystallized and the crystals diffracted X-rays to 2.44 Å resolution.

  16. Study on the serum thyroid hormones levels in patients with acute and chronic bronchitis

    International Nuclear Information System (INIS)

    Objective: To study the changes of serum thyroid hormones levels in patients with acute bronchitis and chronic bronchitis. Methods: Serum T3, FT3, T4, FT4, TSH (with CLIA) and rT3 (with RIA) levels were measured in 107 patients with acute bronchitis, 87 patients with chronic bronchitis and 47 controls. Results: The serum thyroid hormones levels in all these patients were not significantly different from those in controls (P>0.05), except that the serum T3 levels were significantly lower and rT3 levels significantly higher (P3 levels increased significantly and rT3 levels decreased significantly after treatment (P3 levels could reflect the severity of the disease, the T3/rT3 ratio was lowest in the 10 deceased patients. (authors)

  17. Prevalence and risk factors for chronic bronchitis and farmer's lung in French dairy farmers.

    OpenAIRE

    Dalphin, J.C.; Debieuvre, D.; Pernet, D.; Maheu, M F; Polio, J. C.; Toson, B.; Dubiez, A.; Monnet, E; Laplante, J. J.; Depierre, A

    1993-01-01

    The prevalence of chronic bronchitis and of clinical farmer's lung was studied in 30 districts of the French Doubs province in relation to individual (age, sex, smoking) and geographical (altitude) factors. 5703 exclusively dairy farmers (response rate 83%) participated in the study by answering a medical questionnaire. Prevalences of chronic bronchitis and clinical farmer's lung were 9.3% and 1.4% respectively. A logistic regression model was used to evaluate risk factors for chronic bronchi...

  18. Cystic Fibrosis Transmembrane Conductance Regulator Activation by Roflumilast Contributes to Therapeutic Benefit in Chronic Bronchitis

    OpenAIRE

    Lambert, James A.; Raju, S. Vamsee; Tang, Li Ping; McNicholas, Carmel M.; Li, Yao; Courville, Clifford A.; Farris, Roopan F.; Coricor, George E.; Smoot, Lisa H.; Mazur, Marina M.; Dransfield, Mark T; Bolger, Graeme B.; Rowe, Steven M

    2014-01-01

    Cigarette smoking causes acquired cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction and is associated with delayed mucociliary clearance and chronic bronchitis. Roflumilast is a clinically approved phosphodiesterase 4 inhibitor that improves lung function in patients with chronic bronchitis. We hypothesized that its therapeutic benefit was related in part to activation of CFTR. Primary human bronchial epithelial (HBE) cells, Calu-3, and T84 monolayers were exposed to whol...

  19. Bedeutung von Mykoplasmenspezies bei Katzen mit chronischer Bronchitis/felinem Asthma

    OpenAIRE

    Richter, Petra

    2012-01-01

    Etiology of feline bronchial disease remains unknown so far. However, in human medicine, Mycoplasma spp. infections have been made responsible for the exacerbation of asthmatic lung disease for a long time. Aim of this study was to investigate the relevance of Mycoplasma spp. infections for the development of chronic bronchitis/feline asthma. For this purpose, lavage samples of lungs and nose and nasal swabs where taken from cats with chronic bronchitis/feline asthma and from cats without ...

  20. Determinants of chronic bronchitis and lung dysfunction in Western Australian gold miners

    OpenAIRE

    Humble, C; Wing, S.

    1989-01-01

    The relation of chronic bronchitis and respiratory dysfunction to age, tobacco smoking, and occupational exposure to surface and underground mining operations were examined in a cross sectional survey of 1363 men employed in the Kalgoorlie mining industry in 1985. Overall, the prevalence of chronic bronchitis was 14%. Eleven per cent of the workers had obstructive lung disorder (FEV1/FVC less than 0.70) and 9% had restrictive lung disorder (FVC less than 0.80 of predicted for height and age)....

  1. Pseudomembranous aspergillus bronchitis in a double-lung transplanted patient: unusual radiographic and CT features

    International Nuclear Information System (INIS)

    Pseudomembranous aspergillus bronchitis is considered as an early form of invasive pulmonary aspergillosis, a well-known airway infection in immunocompromised patients. Radiologic features concerning invasive aspergillosis of the airways have been reported. However, we describe here an unusual feature of invasive aspergillus bronchitis, never reported to date, observed in a double-lung transplanted patient. Chest radiograph and CT revealed significant peribronchial thickening without any parenchymal involvement. (orig.)

  2. Clinical Peculiarities of Recurrent and Chronic Bronchitis in Children (Part 1)

    OpenAIRE

    Makian, M. V.; Harhaun, V. A.; Maidannyk, V. H.

    2015-01-01

    Subjective manifestations in children with recurrent and chronic bronchitis were the subject of the research.The objective of the research was to evaluate the main clinical manifestations of recurrent and chronic bronchitis, analyze risk factors and preconditions for their occurence in children.Materials and methods of research. The comprehensive clinical and anamnestic examination of 120 children with bronchopulmonary pathology at the age of 3 to 18 (average age was 10.5±1.1 years) was condu...

  3. Effects of N2-laser radiation on the immune system cells of patients with chronic bronchitis

    Science.gov (United States)

    Provorov, Alexander S.; Kozhevnikova, T. A.; Salmin, Vladimir V.

    2001-05-01

    In spite of various investigations devoted to a problem of chronic bronchitis, many problems concerning both the reasons of the origin of this disease, and the essence of the processes, explicating in the bronchial tubes, especially on early stages of the disease, remain insufficiently studied. It makes it difficult to use an integrated approach to chronic bronchitis, that would reflect the peculiarities of its etiology, pathogenesis, its clinical course and efficiency of the therapy. During the last years the data of the clinical laboratory analysis of chronic bronchitis in connection with its immune therapy have been accumulated. In the literature there is a lot of information about the violation of immune reactions in the organism of patients, methods of the immune therapy, the data of the successful application of the intravenous laser therapy in the treatment of obstructive chronic bronchitis and bronchial asthma. However, there is no research explaining the mechanisms of the laser radiation impact on the immune status of patients suffering from chronic bronchitis. According to this it has become extremely urgent to research the mechanisms of the laser radiation impact on immune competent cells of patients suffering from chronic bronchitis.

  4. The Relationships Between Weather and Climate and Attacks of Bronchitis

    Science.gov (United States)

    Talaia, M. A. R.; Saraiva, M. A. C.; Vieira da Cruz, A. A.

    The area of Aveiro, more concretely Aveiro lagoon, a natural laboratory has been con- sidered, for promoting the development and the application of several investigations worked. The importance of the influences of weather and climate on human health has been well known since ancient teams and many decisions concerning human be- haviour it are clearly weather related. However, decisions related to weather criteria can be important and economically significant, but the real economic effect of the weather is difficult to assess. Talaia et al. (2000) and Talaia and Vieira da Cruz (2001) have shown the possible harmful effect of certain meteorological factors on respiratory conditions. Bronchitis is a disease caused by inflammation of the bronchi as a result of infectious agents or air pollutants. In this study our attention is to relate, the be- ginning of bronchitis attacks in the services of urgency of the Hospital of Aveiro with meteorological factors, and the risk group are studied. We used the medical records and the database of meteorological factors. The obtained analysis allows to conclude that some meteorological factors have correlation with the occurrences of the disease and to allow improving the work in the urgency services in the requested periods. The knowledge that will be extracted of this study can be used later in studies that inte- grate other important components for the characterisation of the environmental impact in the area. References: Talaia, M.A.R., Vieira da Cruz, A.A., Saraiva, M.A.C., Amaro, G.S., Oliveira, C.J. and Carvalho, C.F., 2000, The Influence of Meteorological Fac- tors on Pneumonia Emergencies in Aveiro, International Symposium on Human- Biometeorology, St. Petersburg (Pushkin), Russia, pp. 67-68. Talaia, M.A.R. and Vieira of Cruz, A.A., (2001), Meteorological Effects on the Resistance of the Body to Influenza - One Study in Aveiro Region, Proceedings 2nd Symposium of Meteorol- ogy and Geophysics of APMG and 3rd Meeting

  5. Psychological Distress in Women with Chronic Bronchitis in a Fishing Community in the Niger Delta Region of Nigeria

    OpenAIRE

    Victor Aniedi Umoh; Andrew Ibok; Bassey Edet; Ekpe Essien; Festus Abasiubong

    2013-01-01

    Background. Biomass smoke exposure is a known risk factor for chronic bronchitis. Psychiatric comorbidities may have significant impact on the quality of life of patients with chronic bronchitis. Methods. Women who engage in fish preservation by drying over burning firewood in a fishing community were recruited for this survey. The British medical research questionnaire was used to determine chronic bronchitis, and psychological distress was determined using the hospital anxiety and depressio...

  6. Recombination in Avian Gamma-Coronavirus Infectious Bronchitis Virus

    Directory of Open Access Journals (Sweden)

    Mark W. Jackwood

    2011-09-01

    Full Text Available Recombination in the family Coronaviridae has been well documented and is thought to be a contributing factor in the emergence and evolution of different coronaviral genotypes as well as different species of coronavirus. However, there are limited data available on the frequency and extent of recombination in coronaviruses in nature and particularly for the avian gamma-coronaviruses where only recently the emergence of a turkey coronavirus has been attributed solely to recombination. In this study, the full-length genomes of eight avian gamma-coronavirus infectious bronchitis virus (IBV isolates were sequenced and along with other full-length IBV genomes available from GenBank were analyzed for recombination. Evidence of recombination was found in every sequence analyzed and was distributed throughout the entire genome. Areas that have the highest occurrence of recombination are located in regions of the genome that code for nonstructural proteins 2, 3 and 16, and the structural spike glycoprotein. The extent of the recombination observed, suggests that this may be one of the principal mechanisms for generating genetic and antigenic diversity within IBV. These data indicate that reticulate evolutionary change due to recombination in IBV, likely plays a major role in the origin and adaptation of the virus leading to new genetic types and strains of the virus.

  7. [Impaired lung function in patients with moderate chronic obstructive bronchitis].

    Science.gov (United States)

    Nefedov, V B; Popova, L A; Shergina, E A

    2004-01-01

    VC, FVC, FEV1, FEV1/VC%, PEF, MEF25, MEF50, MEF75, TLC, TGV, RV, Raw, Rin, Rex, DLCO-SS, paO2 and paCO2 were determined in 22 patients with moderate chronic obstructive bronchitis (FEV1, 79-50% of the normal value). All the patients were found to have impaired bronchial patency, 90.9% of the patients had lung volume and capacity changes; pulmonary gas exchange dysfunction was present in 72.7%. Bronchial patency impairments were manifested by a decrease in FEV1, FEV1/VC%, PEF, MEF25, MEF50, MEF75, and an increase in Raw, Rin, Rex. Changes in the lung volumes and capacities appeared as higher RV, TGV, TLC, lower VC and FVC. Pulmonary gas exchange dysfunction showed up as a reduction in pO2 and DLCO-SS a reduction and an increase in paCO2. The magnitude of the functional changes observed in most patients was low. Significant and pronounced disorders were seen in one third of the patients. PMID:15719666

  8. CT findings of plastic bronchitis in children after a Fontan operation

    Energy Technology Data Exchange (ETDEWEB)

    Goo, Hyun Woo [University of Ulsan College of Medicine, Department of Radiology and Research Institute of Radiology, Asan Medical Center, Seoul (Korea); Jhang, Won Kyoung; Kim, Young Hwee; Ko, Jae Kon; Park, In Sook [University of Ulsan College of Medicine, Department of Pediatric Cardiology, Asan Medical Center, Seoul (Korea); Park, Jeong-Jun; Yun, Tae-Jin; Seo, Dong-Man [University of Ulsan College of Medicine, Department of Pediatric Cardiac Surgery, Asan Medical Center, Seoul (Korea)

    2008-09-15

    Plastic bronchitis is a rare cause of acute obstructive respiratory failure in children. Life-threatening events are much more frequent in patients with repaired cyanotic congenital heart disease, and most frequent following a Fontan operation. Commonly, the diagnosis is not made until bronchial casts are expectorated. Detailed CT findings in plastic bronchitis have not been described. To describe the CT findings in plastic bronchitis in children after a Fontan operation. Three children with plastic bronchitis after a Fontan operation were evaluated by chest CT. Bronchial casts were spontaneously expectorated and/or extracted by bronchoscopy. Airway and lung abnormalities seen on CT were analyzed in the three children. CT demonstrated bronchial casts in the central airways with associated atelectasis and consolidation in all children. The affected airways were completely or partially obstructed by the bronchial casts without associated bronchiectasis. The airway and lung abnormalities rapidly improved after removal of the bronchial casts. CT can identify airway and lung abnormalities in children with plastic bronchitis after a Fontan operation. In addition, CT can be used to guide bronchoscopy and to monitor treatment responses, and thereby may improve clinical outcomes. (orig.)

  9. CT findings of plastic bronchitis in children after a Fontan operation

    International Nuclear Information System (INIS)

    Plastic bronchitis is a rare cause of acute obstructive respiratory failure in children. Life-threatening events are much more frequent in patients with repaired cyanotic congenital heart disease, and most frequent following a Fontan operation. Commonly, the diagnosis is not made until bronchial casts are expectorated. Detailed CT findings in plastic bronchitis have not been described. To describe the CT findings in plastic bronchitis in children after a Fontan operation. Three children with plastic bronchitis after a Fontan operation were evaluated by chest CT. Bronchial casts were spontaneously expectorated and/or extracted by bronchoscopy. Airway and lung abnormalities seen on CT were analyzed in the three children. CT demonstrated bronchial casts in the central airways with associated atelectasis and consolidation in all children. The affected airways were completely or partially obstructed by the bronchial casts without associated bronchiectasis. The airway and lung abnormalities rapidly improved after removal of the bronchial casts. CT can identify airway and lung abnormalities in children with plastic bronchitis after a Fontan operation. In addition, CT can be used to guide bronchoscopy and to monitor treatment responses, and thereby may improve clinical outcomes. (orig.)

  10. Development of inactivated-local isolate vaccine for infectious bronchitis

    Directory of Open Access Journals (Sweden)

    Darminto

    1999-06-01

    Full Text Available Infectious bronchitis (IB is an acute highly contagious viral respiratory disease of poultry caused by coronavirus. The disease causes high mortality in young chicks, reduce body weight gain in broilers and remarkable drop in egg production. IB can only be controlled by vaccination, but due to the antigenic variation among serotypes of IB viruses, the effective IB vaccine should be prepared from local isolates. The aim of this research is to develop inactivated IB vaccine derived from local IB isolates. Local isolates of IB viruses designated as I-37, I-269 and PTS-III were propagated respectively in specific pathogen free (SPF chicken eggs, the viruses then were inactivated by formaline at final concentration of 1:1,000. Subsequently, the inactivated viruses were mixed and emulsified in oil emulsion adjuvant with sorbitant mono-oleic as an emulsifier. The vaccine then was tested for its safety, potency and efficacy in broiler chickens. Birds inoculated twice with a two-week interval by inactivated vaccine did not show any adverse reaction, either systemic or local reaction. The inoculated birds developed antibody responses with high titre, while antibody of the control birds remain negative. In addition, efficacy test which was conducted in broilers demonstrated that birds vaccinated by live-commercial vaccine and boosted three weeks later by Balitvet inactivated vaccine showed high level of antibody production which provided high level of protection against challenged virus (76% against I-37, 92% against I-269 and 68% against PTS-III challenge viruses. From this study, it can be concluded that inactivated local IB vaccine is considered to be safe, potent and efficacious. The vaccine stimulates high titre of antibody responses, which provide high level of protection against challenged viruses.

  11. β-carotene protects rats against bronchitis induced by cigarette smoking

    Institute of Scientific and Technical Information of China (English)

    庞宝森; 王辰; 翁心植; 唐小奈; 张红玉; 牛淑洁; 毛燕玲; 辛平; 黄秀霞; 张海燕; 祝锦

    2003-01-01

    Objective To investigate the protective effects of β-carotene in rats against the development of chronic bronchitis induced by cigarette smoking. Results Long-term cigarette smoking caused an obvious increase in the amount of IL-6, IL-8 and LPO and a sharp decrease in the levels of NO and SOD in smoking animals compared to controls. β-carotene intake reversed all the changes induced by smoking and alleviated the pathological changes caused by chronic bronchitis. Conclusions Quantitative oral intake of β-carotene had protective effects against chronic bronchitis induced by long-term cigarette smoking, which was associated with the increased production of NO, the clearance of some oxidative free radicals (OFR) and the alleviation of chronic inflammation.

  12. Can eosinophilic bronchitis be considered as an occupational disease? Medical certification aspects

    Directory of Open Access Journals (Sweden)

    Aneta Kleniewska

    2013-08-01

    Full Text Available Eosinophilic bronchitis (EB is a condition which can be associated with occupational exposure to low, as well as to high molecular weight allergens. The prevalence of occupational eosinophilic bronchitis is unknown and the data concerning its work-related etiology are available only from the case reports. However, there is a need to establish the principles, especially in the context of medical certification among workers occupationally exposed to allergens. This paper reviews current knowledge on the etiology, clinical features, and diagnostic procedures in the eosinophilic bronchitis. The importance of EB, especially in view of the problems emerging in the prophylactic care taken by occupational health services and the principles of medical certification when occupational etiology is suspected are also presented. Med Pr 2013;64(4:569–578

  13. [Early detection of chronic dust-induced bronchitis in the workers of coal mines in Rostov region].

    Science.gov (United States)

    Zabolotnikova, O D; Piktushanskaia, I N; Kutovoĭ, V I

    1994-01-01

    To diagnose mild forms of dust bronchitis in miners, the medical examination covered pulmonary ventilation parameters. The examination revealed bronchial obstruction, so early stages of bronchitis became 2-2.5 times more frequently diagnosed. Registration of flow-volume curve in forced expiration appeared to be the most productive functional test. PMID:7866714

  14. Psychological Distress in Women with Chronic Bronchitis in a Fishing Community in the Niger Delta Region of Nigeria

    Directory of Open Access Journals (Sweden)

    Victor Aniedi Umoh

    2013-01-01

    Full Text Available Background. Biomass smoke exposure is a known risk factor for chronic bronchitis. Psychiatric comorbidities may have significant impact on the quality of life of patients with chronic bronchitis. Methods. Women who engage in fish preservation by drying over burning firewood in a fishing community were recruited for this survey. The British medical research questionnaire was used to determine chronic bronchitis, and psychological distress was determined using the hospital anxiety and depression scale. Results. A total of 342 women were recruited for this study and 63 of them had chronic bronchitis. 96 women had features suggestive of psychological distress: 57 (16.6% women with anxiety, 51 (14.9% women with depression and 12 women (3.5% had combined features. Psychological distress was more common among women with chronic bronchitis. Anxiety was significantly associated with chronic bronchitis and the level of biomass exposure while depression was significantly associated with chronic bronchitis, level of exposure, and a history of sleeping in the fish smoking room. Conclusion. Anxiety and depression show significant association with chronic bronchitis among women with biomass smoke exposure with the level of exposure having an aggravating effect on the relationship.

  15. Radionuclide methods of assessment of external respiration in chronic obstructive bronchitis

    International Nuclear Information System (INIS)

    A trial was designet to study shifts in various mechanisms of external respiration (ER)distress in chronic obstructive bronchitis by type of respiration insufficiency (RI). Combinet clinicoroentgenological, spirographic, endoscopic and radionuclide (133Xe radiopneumography and 99Tc scintigraphy) examinations were conducted in 66 patients. The following parameters appeared most informative in studying ER in the bronchitis patients with radionuclide techniques: the volume of ventilated alveoli, respiratory capacity, total and functional residual lung capacity, index ventilation/blood flow, capillary blood flow, time of half elimination of Xe from the alveoli and vascular bed. The above parameters change for the worse with progressive deterioration of external respiration

  16. Nebuhaler or nebulizer for high dose bronchodilator therapy in chronic bronchitis: a comparison.

    Science.gov (United States)

    Allen, M B; Pugh, J; Wilson, R S

    1988-10-01

    We have compared the clinical efficacy of high dose terbutaline sulphate (10 mg four times daily) delivered by either a Nebuhaler or jet nebulizer in 13 patients with chronic bronchitis in a 2-week, open, crossover study. Both treatment regimens improved run-in symptom scores but no significant changes were recorded in peak flow and spirometry. Side-effects were more common with the Nebuhaler and more patients preferred the nebulizer. However, the Nebuhaler is an alternative therapeutic option for delivery of high doses of bronchodilators in patients with chronic bronchitis. PMID:3076792

  17. High incidence of rickets in children with wheezy bronchitis in a developing country1

    OpenAIRE

    El-Radhi, A Sahib; Mansor, N; Majeed, M; Ibrahim, M

    1982-01-01

    The incidence of rickets in 100 Iraqi infants with wheezy bronchitis (24%) exceeded by two and a half times that found in age-matched controls (9%), and by ten times when only those with severe rickets were considered. The reason for this is not entirely clear, but could be related to the fact that the infants with wheezy bronchitis weighed more and therefore had grown faster than the control group. This itself could be related to the higher incidence of breastfeeding in the infants with whee...

  18. Clinical X-ray characteristics of chronic bronchitis in workers of coal mines

    International Nuclear Information System (INIS)

    100 workers of coal mines with chronic dusty bronchitis are examined. The roentgenological manifestations of different stages of the diseases with respect to the clinical picture and function of external breath according to the data of roentgenopneumopolygraphy, are characterized. The attention is paid to a most pronounced violation of external breath function in this category of patients. The peculiarities of clinico-roentgenological picture of dust bronchitis found should be taken into account when solving the problems of medical labor examination. 8 refs.; 3 figs

  19. Radioimmunological allergy diagnostics in infants suffering from asthmatoid bronchitis, bronchial asthma, and hay fever

    International Nuclear Information System (INIS)

    The occurence of circulating specific antibodies against milk protein, hen protein, fish (cod), against cat, dog and horse epithelium as well as against 2 types of house dust was investigated with 11 children in the age of 1-6 years having asthmatoid bronchitis, 23 children aging from 2-15 years with bronchial asthma and 3 children aging from 6-13 years with hay fever, using the radioallergosorbens test (RAST). Children having asthmatoid bronchitis for the first time exhibited a smaller number and a lesser extent of positive radioallergosorben test results then children with bronchial asthma. The children with hay fever exhibited exclusively negative test results. (orig./LN)

  20. Dynamic scintigraphy of the lungs with 133Xe in chronic bronchitis

    International Nuclear Information System (INIS)

    A method of dynamic scintigraphy with 133Xe Was used to study regional ventilation and regional pulmonary blood flow in 58 persons (14 practically healthy persons and 44 patients with chronic bronchitis). This data obtained were assessed visUally and sub ected to a quantitative processing according to the above-mentioned program. Quantitative distinctions in regional values of the residnal volume, a ratio of the residual volume to the general capacity, the time of mixing, a half-period of washing off made it possible to distinguish clearly between two forms of chronic bronchitis (non-obstructive and a form with the noticeable obstructive syndrome)

  1. Association between Ambient Air Pollution and Outpatient Visits for Acute Bronchitis in a Chinese City

    Institute of Scientific and Technical Information of China (English)

    GUO Li Juan; ZHAO Ang; CHEN Ren Jie; KAN Hai Dong; KUANG Xing Ya

    2014-01-01

    Objective To investigate the short-term association between outdoor air pollution and outpatient visits for acute bronchitis, which is a rare subject of research in the mainland of China. Methods A time-series analysis was conducted to examine the association of outdoor air pollutants with hospital outpatient visits in Shanghai by using two-year daily data (2010-2011). Results Outdoor air pollution was found to be associated with an increased risk of outpatient visits for acute bronchitis in Shanghai. The effect estimates of air pollutants varied with the lag structures of the concentrations of the pollutants. For lag06, a 10μg/m3 increase in the concentrations of PM10, SO2, and NO2 corresponded to 0.94%(95%CI:0.83%, 1.05%), 11.12%(95%CI:10.76%, 11.48%), and 4.84%(95%CI: 4.49%, 5.18%) increases in hospital visits for acute bronchitis, respectively. These associations appeared to be stronger in females (P Conclusion Our analyses have provided the first evidence that the current air pollution level in China has an effect on acute bronchitis and that the rationale for further limiting air pollution levels in Shanghai should be strengthened.

  2. S2 expressed from recombinant virus confers broad protection against infectious bronchitis virus

    Science.gov (United States)

    We previously demonstrated that overexposing the IBV (infectious bronchitis virus) S2 to the chicken immune system by means of a vectored vaccine, followed by boost with whole virus, protects chickens against IBV showing dissimilar S1. We developed recombinant Newcastle disease virus (NDV) LaSota (...

  3. Lung mucociliary transport function in chronic bronchitis and radionuclide methods of its investigation (a review)

    International Nuclear Information System (INIS)

    Several methods for studying lung clearance of smokers and non-smoking patients with chronic bronchitis (CB) are described. Modified technique for investigating mucociliary transport (MCT) in CB patients, using 99mTc-macroaggregate of human serum albumin, is suggested. The method enables to examine more patients and obtain the most comprehensive data on MCT state on any level of tracheobronchial tree

  4. Histone deacetylase activity and recurrent bacterial bronchitis in severe eosinophilic asthma.

    Science.gov (United States)

    Zuccaro, L; Cox, A; Pray, C; Radford, K; Novakowski, K; Dorrington, M; Surette, M G; Bowdish, D; Nair, P

    2016-04-01

    An increase in P13 Kinase activity and an associated reduction in histone deacetylase activity may contribute to both relative steroid insensitivity in patients with severe eosinophilic asthma and impaired macrophage scavenger function and susceptibility to recurrent infective bronchitis that may, in turn, contribute to further steroid insensitivity. PMID:26715426

  5. Correlates of COPD and chronic bronchitis in nonsmokers: data from a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Khayat G

    2012-09-01

    Full Text Available Mirna Waked,1 Joseph Salame,2 Georges Khayat,3 Pascale Salameh41Faculty of Medicine, Balamand University, and St George Hospital, Beirut, Lebanon; 2Lebanese University, Faculty of Medicine, Beirut, Lebanon; 3Faculty of Medicine, St Joseph University and Hôtel Dieu de France Hospital, Beirut, Lebanon; 4Lebanese University, Faculties of Pharmacy and Public Health, Beirut, LebanonPurpose: Our objective was to assess the prevalence of chronic bronchitis and chronic obstructive pulmonary disease (COPD and their correlates among a Lebanese nonsmoker group.Material and methods: A cross-sectional study was conducted between October 2009 and September 2010, using a multistage cluster sample throughout Lebanon including Lebanese residents aged 40 years and above with no exclusion criteria. Pre- and postbronchodilator spirometry measurements were performed and carbon monoxide level was measured in exhaled air. COPD was defined and classified according to the Global Initiative for Chronic Obstructive Lung Disease guidelines or according to the lower limit of normal (forced expiratory volume in 1 second/forced vital capacity postbronchodilator < 5th percentile of the healthy population having the same age and sex. Chronic bronchitis was defined by the declaration of morning cough and expectorations for more than 3 months a year over more than 2 years in individuals with normal spirometry.Results: Out of 2201 individuals, 732 were never-smokers: 25 (3.4% of them had COPD, and 86 (11.75% fulfilled the definition of chronic bronchitis. Correlates of COPD included a childhood respiratory disease, house heated by diesel, and older age. On the other hand, correlates of chronic bronchitis included childhood respiratory diseases, living in southern Lebanon versus other regions, heating home by gas, older age, number of smokers at work, and lower height.Conclusion: A substantial percentage of the nonsmoking population may exhibit chronic bronchitis or COPD. The

  6. Comparison of right ventricular weight at necropsy in interstitial pulmonary fibrosis and in chronic bronchitis and emphysema.

    OpenAIRE

    Packe, G E; Cayton, R M; Edwards, C. W.

    1986-01-01

    The ventricular weights in 43 patients with interstitial pulmonary fibrosis were retrospectively compared with those in 172 patients with emphysema and chronic bronchitis. The mean right ventricular weight of patients with interstitial pulmonary fibrosis and those with emphysema and chronic bronchitis was 85.5 g (SD 23.2) and 88.8 g (34.3), respectively. Thirty five patients (81%) with interstitial pulmonary fibrosis had a right ventricular weight over 65 g compared with 124 (72%) of those wi...

  7. A liquid phase blocking ELISA for the detection of antibodies against infectious bronchitis virus

    Directory of Open Access Journals (Sweden)

    Cardoso T.C.

    1999-01-01

    Full Text Available A liquid phase blocking ELISA (LPB-ELISA was developed for the detection and measurement of antibodies against infectious bronchitis virus (IBV. The purified and nonpurified virus used as antigen, the capture and detector antibodies, and the chicken hyperimmune sera were prepared and standardized for this purpose. A total of 156 sera from vaccinated and 100 from specific pathogen-free chickens with no recorded contact with the virus were tested. The respective serum titers obtained in the serum neutralization test (SNT were compared with those obtained in the LPB-ELISA. There was a high correlation (r2 = 0.8926 between the two tests. The LPB-ELISA represents a single test suitable for the rapid detection of antibodies against bronchitis virus in chicken sera, with good sensitivity (88%, specificity (100% and agreement (95.31%.

  8. Investigation into the effect of fenoterol on mucociliary clearance in patients with chronic bronchitis

    International Nuclear Information System (INIS)

    We investigated the effects of fenoterol, a selective β2 adrenoceptor stimulant, on mucociliary clearance in 12 patients with chronic bronchitis. Mucociliary clearance was measured with a scintillation camera after inhalation of a 99mTc labeled aerosol. Fenoterol was administered one h after acquisition commenced and imaging was maintained for a further two h. Three regions of interest (ROI) were selected over each lung to generate time activity curves. Corrections for decay, alveolar deposition (using 24 h image), cough and movement of activity through each ROI were carried out. An exponential function was fitted to the clearance curves to determine clearance rates. The increase in percentage clearance after fenoterol administration for the left and right whole lung ROI was 35% and 36% per h respectively (P = 0.006 and 0.020). Fenoterol enhances cilial clearance in chronic bronchitis patients. (orig.)

  9. Detection and identification of infectious bronchitis virus by RT-PCR in Iran.

    Science.gov (United States)

    Homayounimehr, Alireza; Pakbin, Ahmad; Momayyez, Reza; Fatemi, Seyyedeh Mahsa Rastegar

    2016-06-01

    Infectious bronchitis virus (IBV) causes severe diseases in poultry with significant economic consequences to the poultry industry in Iran. The aim of this study was the detection and identification of IBV by reverse transcription(RT)-PCR in Iran. Ten IB virus strains were detected by testing trachea, cecal tonsil, and kidney tissues collected from broiler and layer farms in Iran. In order to detect infectious bronchitis virus, an optimized RT-PCR was used. Primers targeting the conserved region of known IBV serotypes were used in the RT-PCR assay. Primers selectively detecting Massachusetts and 793/B type IB viruses were designed to amplify the S1 gene of the virus and used in the nested PCR test. Our findings indicate the circulation of at least three genotypes of IB viruses (Massachusetts, 793/B, and variant 2) among poultry flocks. PMID:27010714

  10. Effects of prednisone on eosinophilic bronchitis in asthma: a systematic review and meta-analysis*,**

    OpenAIRE

    Sakae, Thiago Mamôru; Maurici, Rosemeri; Trevisol, Daisson José; Pizzichini, Marcia Margaret Menezes; Pizzichini, Emílio

    2014-01-01

    OBJECTIVE: To evaluate the effect size of oral corticosteroid treatment on eosinophilic bronchitis in asthma, through systematic review and meta-analysis. METHODS: We systematically reviewed articles in the Medline, Cochrane Controlled Trials Register, EMBASE, and LILACS databases. We selected studies meeting the following criteria: comparing at least two groups or time points (prednisone vs. control, prednisone vs. another drug, or pre- vs. post-treatment with prednisone); and evaluating par...

  11. Effects of prednisone on eosinophilic bronchitis in asthma: a systematic review and meta-analysis,

    OpenAIRE

    Thiago Mamôru Sakae; Rosemeri Maurici; Daisson José Trevisol; Marcia Margaret Menezes Pizzichini; Emílio Pizzichini

    2014-01-01

    OBJECTIVE: To evaluate the effect size of oral corticosteroid treatment on eosinophilic bronchitis in asthma, through systematic review and meta-analysis. METHODS: We systematically reviewed articles in the Medline, Cochrane Controlled Trials Register, EMBASE, and LILACS databases. We selected studies meeting the following criteria: comparing at least two groups or time points (prednisone vs. control, prednisone vs. another drug, or pre- vs. post-treatment with prednisone); and evaluating par...

  12. Role of P G E 2 in Asthma and Nonasthmatic Eosinophilic Bronchitis

    OpenAIRE

    Sastre, Beatriz; del Pozo, Victoria

    2012-01-01

    Eosinophilic bronchitis is a common cause of chronic cough, which like asthma is characterized by sputum eosinophilia, but unlike asthma there is no variable airflow obstruction or airway hyperresponsiveness. Several studies suggest that prostaglandins may play an important role in orchestrating interactions between different cells in several inflammatory diseases such as asthma. PGE2 is important because of the multiplicity of its effects on immune response in respiratory diseases; however, ...

  13. Investigation of Neurokinin‐1 Receptor Antagonism as a Novel Treatment for Chronic Bronchitis in Dogs

    OpenAIRE

    Grobman, M.; Reinero, C.

    2016-01-01

    Background Canine chronic bronchitis (CCB) results in cough lasting ≥2 months and airway inflammation. Adverse effects include risk of secondary infection associated with lifelong corticosteroid administration and prompt investigation into alternative therapies. Neurogenic pathways mediated by tachykinins that bind neurokinin (NK) 1 receptors may induce cough and airway inflammation. Maropitant,1 a NK‐1 receptor antagonist, has been advocated for treatment of CCB based on anecdotal improvemen...

  14. Moxifloxacin in the management of exacerbations of chronic bronchitis and COPD

    OpenAIRE

    Miravitlles, Marc

    2007-01-01

    Bacteria are isolated in more than 50% of exacerbations of chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD). The most prevalent respiratory pathogens include Gram-positive (Streptococcus pneumoniae) and Gram-negative (Haemophilus influenzae, Moraxella catarrhalis) microorganims. Moxifloxacin is a fourth-generation fluoroquinolone that has been shown to be effective against respiratory pathogens, including atypicals and those resistant to most common antibiotics. The bi...

  15. [Effects of essential oil on lipid peroxidation and lipid metabolism in patients with chronic bronchitis].

    Science.gov (United States)

    Siurin, S A

    1997-01-01

    Natural concentrations of some essential oils were examined for effects on the system lipid peroxidation-antioxidant defense and lipid metabolism in 150 patients with chronic bronchitis. Lowering of plasm levels of dienic conjugates and ketons, activation of catalase in red cells characteristic of antioxidant effect were observed in exposure to essential oils of rosemary, basil, fir, eucalyptus. Lavender essential oil promotes normalization of the level of total lipids, ratio of total cholesterol to its alpha-fraction. PMID:9490339

  16. Comparative evaluation of lung ventilation in patients with dust bronchitis and pneumoconiosis by roentgenopneumopolygraphy

    International Nuclear Information System (INIS)

    The results of roentgenopneumopolygraphy in 290 coal miners are analyzed. Localized diffuse ventilation disorders are detected, that are most pronounced in the upper and central lung regions. In all patients with dust bronchitis local and diffuse emphysematous ventilation disorders were detectable. In all patients with pneumoconiosis combined functional and morphologic changes were found. The use of X-ray function tests in coal miners facilitates an early detection of pathologic lung processes. (author)

  17. Effect of smoking cessation on airway inflammation of rats with chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    LI Qing-yun; HUANG Shao-guang; WAN Huan-ying; WU Hua-cheng; ZHOU Tong; LI Min; DENG Wei-wu

    2007-01-01

    Background Smoking is the major cause of airway inflammation in chronic obstructive pulmonary disease (COPD),and smoking cessation is regarded as one of the important strategies for prevention and treatment of the inflammation.The inflammation of the chronic airway may be present and deteriorated even if the COPD patients stop smoking.Whether and how early smoking cessation affects the progress of inflammation is still obscure. This study was conducted to find the appropriate time for smoking cessation to terminate the airway inflammation in rats with smoke-induced chronic bronchitis.Methods A rat model of COPD was established by passively inhaling smoke mixture. Fifty-four young male Sprague-Dawley rats were randomly divided into 9 groups with different periods of smoke exposure and different time points of cessation. The inflammation markers to be detected included inflammatory cells in the bronchoalveolar lavage fluid (BALF), the myeloperoxidose (MPO) activity, the morphologic changes and the expression of ICAM-1 on the airway epithelium.Results When smoking was terminated at early stage, the inflammatory markers and related indexes were different from those of the typical chronic bronchitis group (group M7) (P<0.01). The pathologic score of group SC7 (2 weeks of smoking cessation after occurrence of typical chronic bronchitis ) was not different from that of group M7, and the level of ICAM-1 was still up-regulated (compared to group M7, P>0.05). Meanwhile, most of inflammatory cells in BALF were neutrophils compared to other groups (P<0.01).When smoking was terminated, the MPO activity was significantly lower than that of group M7 (P<0.01).Conclusions Smoking cessation at early stage can effectively inhibit the inflammatory reaction of COPD. Once chronic bronchitis occurs, little could be improved by smoking cessation.

  18. Impact of heterozygote CFTR Mutations in COPD patients with Chronic Bronchitis

    OpenAIRE

    Raju, S. Vamsee; Tate, Jody H; Peacock, Sandra KG; Fang, Ping; Oster, Robert A.; Dransfield, Mark T.; Steven M Rowe

    2014-01-01

    Background Cigarette smoking causes Chronic Obstructive Pulmonary Disease (COPD), the 3rd leading cause of death in the U.S. CFTR ion transport dysfunction has been implicated in COPD pathogenesis, and is associated with chronic bronchitis. However, susceptibility to smoke induced lung injury is variable and the underlying genetic contributors remain unclear. We hypothesized that presence of CFTR mutation heterozygosity may alter susceptibility to cigarette smoke induced CFTR dysfunction. Con...

  19. Radioisotopic examinations of the functional state of reticuloendothelial cells of the liver in chronic bronchitis

    International Nuclear Information System (INIS)

    Radioisotopic hepatography carried out in 65 patients with chronic obstructive bronchitis and respiratory insufficiency (grades 1-2 and 3) at the phase of remission revealed disorders of the liver circulation and absorptive capacity of reticuloendothelial liver cells. There was a direct dependence between the degree of liver circulation disorders, inhibition of absorptive function of the reticuloendothelial cells of the liver and degree of respiratory insufficiency in these patients

  20. Immunological status in participants of Chernobyl accident clean-up with chronic bronchitis

    International Nuclear Information System (INIS)

    Immunological status in participants of Chernobyl accident clean-up with chronic bronchitis was investigated. Patients had more tension elements of immune system at increased level of obstruction. Adaptive reaction in the liquidators was formed on lower level of organism reaction and imbalance in immune competence subsystems developed. This phenomenon is a negative prognostic sign of more serious disease and can cause invalidation of the patients

  1. Evaluation of effectiveness of hydrolyzed dextran in treatment of dust-induced bronchitis

    Energy Technology Data Exchange (ETDEWEB)

    Slinchenko, N.Z.; Filipchenko, L.L.; Volkova, V.M.

    1986-05-01

    An experimental group and a control group identical in age, work experience, dust exposure and expression of disease were treated for dust-induced bronchitis. The control group received broncholytics, anti-inflammatory preparations and physiotherapy; the experimental group received same treatment plus 200 ml of rheopolyglucin, a 10% solution of dextran (water-soluble polysaccharide of glucose), twice a week for 2 to 3 weeks. In addition to general laboratory and clinical methods of investigation, cytologic analysis of sputum before and after treatment was carried out. Results of experiment are given in 3 tables showing: Dynamics of Allergic Signs after Treatment with Rheopolyglucin, Dynamics of Content of Eosinophils in Blood after Treatment, and Cytologic Characteristics of Mucus of Patients with Dust-Induced Bronchitis. Patients treated with rheopolyglucin improved more than control group in abatement of suppurative process in lungs, strengthening of specific cellular and humoral mechanisms of immune response at level of bronchopulmonary system, increased expulsion of mineral dust from lungs and significant reduction of allergic reaction. Results quantitated in tables prove advantages of adding rheopolyglucin to traditional therapy in treatment of dust-induced bronchitis. 19 refs.

  2. Spirometric abnormalities associated with chronic bronchitis, asthma, and airway hyperresponsiveness among boilermaker construction workers

    Energy Technology Data Exchange (ETDEWEB)

    Hauser, R.; Eisen, E,A,; Pothier, L,; Lewis, D,; Bledsoe, T,; Christiani, D.C. [Harvard University, Boston, MA (United States). School of Public Health

    2002-06-01

    In a 2-year longitudinal study of boilermaker construction workers, authors found a significant association between working at oil-fired, coal-fired, and gas-fired industries during the past year and reduced lung function. In the present study, authors investigated whether chronic bronchitis, asthma, or baseline methacholine airway responsiveness can explain the heterogeneity in lung function response to boilermaker work. Exposure was assessed with a work history questionnaire. Spirometry was performed annually to assess lung function. A generalized estimating equation approach was used to account for the repeated-measures design. One hundred eighteen boilermakers participated in the study. Self-reported history of chronic bronchitis and asthma were associated with a larger FEV1 reduction in response to workplace exposure at coal-fired and gas-fired industries. Although a high prevalence (39%) of airway hyperresponsiveness (provocative concentration of methacholine causing a 20% fall in FEVI of {lt} 8 mg/mL) among boilermakers was found, there was no consistent pattern of effect modification by airway responsiveness. Conclusions: Although chronic bronchitis and asthma were associated with a greater loss in lung function in response to hours worked as a boilermaker, and therefore they acted as effect modifiers of the exposure-lung function relationship, airway hyperresponsiveness did not. However, the high prevalence of airway hyperresponsiveness found in the cohort may be a primary consequence of long-term workplace exposure among boilermakers.

  3. Acupuncture as method of treatment and arresting progress of dust-induced bronchitis

    Energy Technology Data Exchange (ETDEWEB)

    Baburina, E.B.; Bykova, E.A.

    1983-10-01

    Acupuncture is an effective therapy for treatment of dust-induced bronchitis. It can be used independently or in combination with medicaments. Fifty men were divided into two groups of 20 and 30. One group was treated by acupuncture alone, the other with combined therapy. Acupuncture produced excellent results; combined treatment, good and satisfactory results. Since acupuncture reduced the possibility of complications, allergic reactions and side effects due to medication, it is an excellent means of preventing progress of dust-induced bronchitis. Patients experience 9 months remission of symptoms after treatment with acupuncture while medical therapy alone only relieves them for 1 to 1 1/2 months. Patients with chronic dust-induced bronchitis should receive a second course of acupuncture in 6 to 8 months to prevent recurrence of symptoms and progress of disease. Because of insufficient study of lasting effects of acupuncture, final conclusions about its effectiveness cannot be made, however, current evidence indicates it is a highly useful therapy. 6 references.

  4. Therapeutic Approaches to Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in Chronic Bronchitis.

    Science.gov (United States)

    Solomon, George M; Raju, S Vamsee; Dransfield, Mark T; Rowe, Steven M

    2016-04-01

    Chronic obstructive pulmonary disease is a common cause of morbidity and a rising cause of mortality worldwide. Its rising impact indicates the ongoing unmet need for novel and effective therapies. Previous work has established a pathophysiological link between the chronic bronchitis phenotype of chronic obstructive pulmonary disease and cystic fibrosis as well as phenotypic similarities between these two airways diseases. An extensive body of evidence has established that cigarette smoke and its constituents contribute to acquired dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) protein in the airways, pointing to a mechanistic link with smoking-related and chronic bronchitis. Recent interest surrounding new drugs that target both mutant and wild-type CFTR channels has paved the way for a new treatment opportunity addressing the mucus defect in chronic bronchitis. We review the clinical and pathologic evidence for modulating CFTR to address acquired CFTR dysfunction and pragmatic issues surrounding clinical trials as well as a discussion of other ion channels that may represent alternative therapeutic targets. PMID:27115953

  5. Cystic Fibrosis Transmembrane Conductance Regulator Activation by Roflumilast Contributes to Therapeutic Benefit in Chronic Bronchitis

    Science.gov (United States)

    Lambert, James A.; Raju, S. Vamsee; Tang, Li Ping; McNicholas, Carmel M.; Li, Yao; Courville, Clifford A.; Farris, Roopan F.; Coricor, George E.; Smoot, Lisa H.; Mazur, Marina M.; Dransfield, Mark T.; Bolger, Graeme B.

    2014-01-01

    Cigarette smoking causes acquired cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction and is associated with delayed mucociliary clearance and chronic bronchitis. Roflumilast is a clinically approved phosphodiesterase 4 inhibitor that improves lung function in patients with chronic bronchitis. We hypothesized that its therapeutic benefit was related in part to activation of CFTR. Primary human bronchial epithelial (HBE) cells, Calu-3, and T84 monolayers were exposed to whole cigarette smoke (WCS) or air with or without roflumilast treatment. CFTR-dependent ion transport was measured in modified Ussing chambers. Airway surface liquid (ASL) was determined by confocal microscopy. Intestinal fluid secretion of ligated murine intestine was monitored ex vivo. Roflumilast activated CFTR-dependent anion transport in normal HBE cells with a half maximal effective concentration of 2.9 nM. Roflumilast partially restored CFTR activity in WCS-exposed HBE cells (5.3 ± 1.1 μA/cm2 vs. 1.2 ± 0.2 μA/cm2 [control]; P < 0.05) and was additive with ivacaftor, a specific CFTR potentiator approved for the treatment of CF. Roflumilast improved the depleted ASL depth of HBE monolayers exposed to WCS (9.0 ± 3.1 μm vs. 5.6 ± 2.0 μm [control]; P < 0.05), achieving 79% of that observed in air controls. CFTR activation by roflumilast also induced CFTR-dependent fluid secretion in murine intestine, increasing the wet:dry ratio and the diameter of ligated murine segments. Roflumilast activates CFTR-mediated anion transport in airway and intestinal epithelia via a cyclic adenosine monophosphate–dependent pathway and partially reverses the deleterious effects of WCS, resulting in augmented ASL depth. Roflumilast may benefit patients with chronic obstructive pulmonary disease with chronic bronchitis by activating CFTR, which may also underlie noninfectious diarrhea caused by roflumilast. PMID:24106801

  6. Effective use of corticosteroids in treatment of plastic bronchitis with hemoptysis in Chinese adults

    Institute of Scientific and Technical Information of China (English)

    Gang WANG; You-juan WANG; Feng-ming LUO; Lei WANG; Li-li JIANG; Lin WANG; Bing MAO

    2006-01-01

    Aim: To investigate whether corticosteroids are effective in the treatment of plastic bronchitis with hemoptysis. Methods: A retrospective, clinical study was undertaken. Thirty two patients with only first episodes of plastic bronchitis with hemoptysis were divided into a steroid group (n=18) treated with glucocorticoids, and a non-steroid group (n=14). The supportive therapy was uniformly applied to both groups, except for glucocorticoids. Variables such as temperature and white blood cell counts were determined. Furthermore, the volume of hemoptysis and bronchial casts were evaluated in detail daily. Results: There was no difference in the demographic data and variables at baseline between both groups (all P>0.05).On days 5,6,7 and 8, the volume of hemoptysis was significantly decreased in the steroid group compared with the non-steroid group (43±15 mL vs 117±33 mL on d 5,29±12mL vs 97±23mL on d 6,18±10mL vs 80±20mL on d 7,and 13±8mL vs 66±14 mL on d 8; all P<0.05), and on d 10 after fibreoptic bronchoscopy, the cases with bronchial casts was reduced evidently in the steroid group in comparison with the non-steroid group (OR=5.69,95% CI=1.76-43.6; P=0.005). There was no significance in mechanical ventilation and mortality between both groups. Conclusion: Despite some limitations of this study, it has been demonstrated that, on the basis of common supportive therapy, corticosteroids would be effective and safe for the treatment of plastic bronchitis with hemoptysis.

  7. THE USAGE OF HALOAEROSOLOTHERAPY IN THE REHABILITATIONAL TREATMENT OF CHILDREN WITH RECCURENT BRONCHITIS

    Directory of Open Access Journals (Sweden)

    LEMKO Ivan

    2015-05-01

    Full Text Available Aim. Comparative evaluation of the effectiveness of various therapeutic complexes on the basis of haloaerosoltherapy in the rehabilitational treatment of children with recurrent bronchitis on the ground of clinical and functional data and further development of recommendations for differentiated treatment. Objectives. Children (at the age of 6-10 years with recurrent bronchitis, who received treatment in conditions of artificial rock salt aerosol medium (haloaerosoltherapy. Material and Methods. 35 children with recurrent bronchitis (RB were examined. All children’s clinical data were monitored; respiratory function was evaluated using spirography. Forced inspiratory vital capacity (FIVC, forced expiratory volume for the 1-st second (FEV1, peak expiratory flow (PEF, forced expiratory flow at the point of 25% from FIVC(FEF25, forced expiratory flow at the point of 50% from FIVC (FEF50, and forced expiratory flow at the point of 75% from FIVC (FEF75 were defined. The patients were treated with the help of two therapeutic complexes (TC. 12 children were treated by the first TC which included haloaerosoltherapy (14 procedures, in well-equipped room with the initial concentration of rock salt aerosol 40 mg/m3 and the predominance of fine powder fraction (<80%. The first procedure lasted 10 minutes, the second – 20 minutes, the third and the following ones – 30 minutes. The concentration and dispersity of haloaerosol were measured with the help of special laser optical system. 23 children underwent second TC, which included 12 procedures of singlet oxygen therapy in the form of foam additionally to the haloaerosoltherapy sessions. Results. At the beginning of the treatment children had no signs of the acute phase of the disease. Though there were some symptoms which testify that the inflammatory process and functional recovery are not finished yet after the acute phase of the recurrent bronchitis. The clinical picture was confirmed by the major

  8. Measurement of Antibodies to Infectious Bronchitis Virus in Indigenous Chicken Flocks Around Maharlou Lake in Iran

    Directory of Open Access Journals (Sweden)

    M.M. Hadipour

    2011-06-01

    Full Text Available To evaluate the seroprevalence of Infectious Bronchitis Virus (IBV in indigenous chicken flocks, serum samples from 200 mature indigenous chickens in villages around Maharlou Lake in Southwest of Iran were tested for IBV antibodies using commercial IBV Enzyme-Linked Immunosorbent Assay (ELISA. The studied indigenous chickens had not been previously vaccinated and showed no clinical signs of disease. The overall ELISA titer and seroprevalence of IBV antibodies revealed in this study were 1427 and 68%, respectively. The results indicate a relatively high prevalence of IBV in indigenous chicken flocks in Southwest of Iran and necessitate the regular vaccination programme against IB in native flocks.

  9. Detection of infectious bronchitis virus strains similar to Japan in Taiwan.

    Science.gov (United States)

    Tsai, Cheng-Ta; Tsai, Hsin-Fu; Wang, Ching-Ho

    2016-06-01

    A total of 1,320 tracheal samples from 66 broiler flocks sent to slaughterhouses and 42 tracheal samples from 42 flocks of local chickens in the field were collected for infectious bronchitis virus (IBV) gene detection by reverse transcription polymerase chain reaction using nucleocapsid-specific primers and spike-specific primers. Prevalence in broiler flocks was 39.4% (26/66) and in local chicken flocks was 11.9% (5/42). Several IBVs similar to Japan were detected in Taiwan. One-direction neutralization revealed that the reference antisera did not offer protection against the IBVs similar to those from Japan. PMID:26822119

  10. Study on the salivary contents of secretory immunoglobulin A (SigA) and lysome (Lys) in patients with chronic bronchitis

    International Nuclear Information System (INIS)

    Objective: To study the sailic levels of SIgA and lys in patients with chronic bronchitis. Methods: Sailic SIgA (with RIA) and lys (with immunodiffusionassay) levels were measured in 38 patients with chronic bronchitis both before and after treatment as well as in 35 controls. Results: Before treatment the saliac SIgA and lys levels in the patients were significantly higher than those in controls (P<0.01). After treatment for 2 weeks, the sailic SIgA and lys levels, though dropped markedly, remained significantly higher than those in controls (P<0.05). Conclusion: Changes of sailic SIgA and lys levels content after treatment might be of prognostic importance in patients with chronic bronchitis. (authors)

  11. Adjuvant effects of mannose-binding lectin ligands on the immune response to infectious bronchitis vaccine in chickens with high or low serum mannose-binding lectin concentrations

    DEFF Research Database (Denmark)

    Kjærup, Rikke Munkholm; Dalgaard, Tina Sørensen; Norup, Liselotte Rothmann; Bergman, Ingrid-Maria; Sørensen, Poul; Juul-Madsen, Helle Risdahl

    2014-01-01

    MBL participates in the protection of hosts against virus infections. Infectious bronchitis (IB) is a highly contagious disease of economic importance in the poultry industry caused by the coronavirus infectious bronchitis virus (IBV). MBL has earlier been described to play a potential role in the...

  12. [Effects of occupational factors on the natural course of chronic bronchitis in a prospective observation of the industrial population].

    Science.gov (United States)

    Jedrychowski, W

    1978-01-01

    Frequence of occurrence and dynamics of chronic bronchitis symptoms as well as barrier syndrome in the examined men in a plant was connected primarily with tobacco smoking and less with the age. Mean values FEV1 depended on the age of examined workers and the rate of spirometric values decrease increased with the age and was connected with smoking habit. It has been ascertained that there is a direct relationship between air contamination with dusts and fluorides and frequency of occurrence of chronic bronchitis symptoms, maintenance of the symptoms for 5 years and decrease of FEV1 value at that period especially in a group of smokers. PMID:723614

  13. Study of regional ventilation of the lungs in patients with chronic bronchitis, making use of scanning densitometry of tomograms

    International Nuclear Information System (INIS)

    Method for investigation of regional ventilation of the lungs with the use of tomography and scanning densitometry was suggested. The method makes it possible to assess the expressiveness of changes in the lungs in patients with chronic bronchitis before and in the process of treatment. The new method permitted to reveal the disturbances of regional ventilation of the lungs in patients with chronic obstructive and non-obstructive bronchitis and to establish a latent respiratory insufficiency. The data of suggested method of scanning densitometry of tomograms of the lungs are in agreement with results of examinations of external respiration function

  14. Studies on Molecular Variant Mechanism of Infectious Bronchitis Viruses of Beijing Area

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Using reverse transcription-nested Polymerase Chain Reaction(RT-nested PCR), the S1 gene hypervariable regions of Avian Infectious Bronchitis Viruses(IBV) strains BJ1, BJ2, BJ3, isolated from Beijing areas, were amplified successfully. The region consists of 1054 bp of 5'-end of S1 gene which were regarded as the most variable region among IBV strains. Sequences of the S1 gene were determined from recombinant plasmids by using the dideoxy sequencing technique in two directions. Comparing three isolates with standard strains M41, Beaudette, vaccine strain H120 and one isolated strain D41 from Guangdong province, it was shown they were more homology in nucleotide sequence and deduced amino acid sequence with M41 than Beaudette and H120. However, secondary structure of their encoding proteins are more similar with H120 than M41 and Beaudette strains. All of these indicate there are complex relationship among difference of nucleotide sequence, changes of virus determinants and serotypes in Infectious Bronchitis Virus.

  15. Efficacy and Tolerability of 5- vs 10-Day Cefixime Therapy in Acute Exacerbations of Chronic Bronchitis.

    Science.gov (United States)

    Lorenz, J; Steinfeld, P; Drath, L; Keienburg, T; Troester, K

    1998-01-01

    The efficacy and tolerability of oral cefixime 400mg once daily for 5 days was compared with standard 10-day therapy in a multicentre, double-blind, randomised, controlled clinical trial of 222 patients with acute exacerbations of chronic bronchitis. Clinical and bacteriological efficacy were assessed after 6, 11 and 30 days. A total of 167 patients were evaluable for efficacy on a per-protocol basis. Clinical efficacy (cure or improvement based on the quality and quantity of expectorated sputum and symptoms of dyspnoea) at day 11 was statistically equivalent (p < 0.01) between the treatment groups, with a successful clinical response achieved in 91% (5-day) and 89% (10-day) of patients. Bacteriological efficacy was also similar with 5- and 10-day treatment. During treatment, more patients reported an adverse event possibly or probably related to the study medication in the 10-day than in the 5-day treatment group (19 vs 14%). However, this difference was not statistically significant. Oral cefixime 400mg once daily is an effective and well tolerated treatment for acute exacerbations of chronic bronchitis. Short-term (5-day) therapy offers clinical efficacy similar to that of standard (10-day) therapy. PMID:18370461

  16. The proteome of the infectious bronchitis virus Beau-R virion.

    Science.gov (United States)

    Dent, Stuart D; Xia, Dong; Wastling, Jonathan M; Neuman, Benjamin W; Britton, Paul; Maier, Helena J

    2015-12-01

    Infectious bronchitis is a highly contagious respiratory disease of poultry caused by the coronavirus infectious bronchitis virus (IBV). It was thought that coronavirus virions were composed of three major viral structural proteins until investigations of other coronaviruses showed that the virions also include viral non-structural and genus-specific accessory proteins as well as host-cell proteins. To study the proteome of IBV virions, virus was grown in embryonated chicken eggs, purified by sucrose-gradient ultracentrifugation and analysed by mass spectrometry. Analysis of three preparations of purified IBV yielded the three expected structural proteins plus 35 additional virion-associated host proteins. The virion-associated host proteins had a diverse range of functional attributions, being involved in cytoskeleton formation, RNA binding and protein folding pathways. Some of these proteins were unique to this study, while others were found to be orthologous to proteins identified in severe acute respiratory syndrome coronavirus virions and also virions from a number of other RNA and DNA viruses. PMID:27257648

  17. Immune Responses to Virulent and Vaccine Strains of Infectious Bronchitis Viruses in Chickens.

    Science.gov (United States)

    Chhabra, Rajesh; Chantrey, Julian; Ganapathy, Kannan

    2015-11-01

    Infectious bronchitis (IB) is an acute and highly contagious chicken viral disease, causing severe economic losses to poultry producers worldwide. In the last few decades, infectious bronchitis virus (IBV) has been extensively studied, but knowledge of immune responses to virulent or vaccine strains of IBVs remains limited. This review focuses on fundamental aspects of immune responses against IBV, including the role of pattern recognition receptors (PRRs) in identification of conserved viral structures and the role of different components of innate immunity (e.g., heterophils, macrophages, dendritic cells, acute phase protein, and cytokines). Studies on adaptive immune activation and the role of humoral and cellular immunity in IBV clearance are also reviewed. Multiple interlinking immune responses are essential for protection against virulent IBVs, including passive, innate, adaptive, and effector T cells active at mucosal surfaces. Although the development of approaches for chicken transcriptome and proteome analyses have greatly helped the understanding of the underlying genetic mechanisms for immunity, there are still major knowledge gaps, such as the role of mucosal and cellular responses to IBVs. In view of recent reports of emergent IBV variants in many countries, there is renewed interest in a more complete understanding of poultry immune responses to both virulent and vaccine strains of IBVs. This will be critical for developing new vaccine or vaccination strategies and other intervention programs. PMID:26301315

  18. Airflow, transport and regional deposition of aerosol particles during chronic bronchitis of human central airways.

    Science.gov (United States)

    Farkhadnia, Fouad; Gorji, Tahereh B; Gorji-Bandpy, Mofid

    2016-03-01

    In the present study, the effects of airway blockage in chronic bronchitis disease on the flow patterns and transport/deposition of micro-particles in a human symmetric triple bifurcation lung airway model, i.e., Weibel's generations G3-G6 was investigated. A computational fluid and particle dynamics model was implemented, validated and applied in order to evaluate the airflow and particle transport/deposition in central airways. Three breathing patterns, i.e., resting, light activity and moderate exercise, were considered. Using Lagrangian approach for particle tracking and random particle injection, an unsteady particle tracking method was performed to simulate the transport and deposition of micron-sized aerosol particles in human central airways. Assuming laminar, quasi-steady, three-dimensional air flow and spherical non-interacting particles in sequentially bifurcating rigid airways, airflow patterns and particle transport/deposition in healthy and chronic bronchitis (CB) affected airways were evaluated and compared. Comparison of deposition efficiency (DE) of aerosols in healthy and occluded airways showed that at the same flow rates DE values are typically larger in occluded airways. While in healthy airways, particles deposit mainly around the carinal ridges and flow dividers-due to direct inertial impaction, in CB affected airways they deposit mainly on the tubular surfaces of blocked airways because of gravitational sedimentation. PMID:26541595

  19. Adaptation of infectious bronchitis virus in primary cells of the chick embryo chorioallantoic membrane

    Directory of Open Access Journals (Sweden)

    M. H. Mohammed

    2013-06-01

    Full Text Available The susceptibility of the primary chick embryo chorioallontoic membrane cells to infectious bronchitis virus was evaluated after twenty consecutive passages in chick embryo chorioallontoic membrane cells. Virus replication was monitored by cytopathic observation, indirect immunoperoxidase, and reverse transcription polymerase chain reaction (RT-PCR. At 72 hours post-infection (p.i. in third passage, the cytopathic effect was characterized by rounding up of cells, monolayer detachment, intracytoplasmic brownish colouration was readily observed by immunoperoxidase from 24 hours p.i in third passage, and at all times the extracted viral RNA from IBV-infected monolayers was demonstrated by RT-PCR. Tissue culture ineffective dose50 (TCID50 was used to measure virus titration performed on primary chick embryo chorioallontoic membrane cells and the titre in twenty passage was 108.6 TCID50/ml. The results obtained in this study suggested that the primary chick embryo chorioallontoic membrane cells can be used for adaptation infectious bronchitis virus (IBV and may be considered a step forward for the use of these cells in the future for IBV vaccine production

  20. Radiation bronchitis and stenosis secondary to high dose rate endobronchial irradiation

    International Nuclear Information System (INIS)

    The purpose of the study was to describe a new clinical entity observed in follow-up bronchoscopies in patients who were treated with high dose rate and medium dose rate remote afterloading brachytherapy of the tracheobronchial tree. Patients were treated by protocol with medium dose rate, 47 patients receiving 1000 cGy at a 5 mm depth times three fractions, high dose rate 144 patients receiving 1000 cGy at a 10 mm depth for three fractions and high dose rate 151 patients receiving cGy at a 10 mm depth for three fractions followed by bronchoscopy. Incidence of this entity was 9% for the first group, 12% for the second, and 13% for the third group. Reactions were grade 1 consisting of mild inflammatory response with a partial whitish circumferential membrane in an asymptomatic patient; grade 2, thicker complete white circumferential membrane with cough and/or obstructive problems requiring intervention; grade 3, severe inflammatory response with marked membranous exudate and mild fibrotic reaction; and grade 4 a predominant fibrotic reaction with progressive stenosis. Variables associated with a slightly increased incidence of radiation bronchitis and stenosis included: large cell carcinoma histology, curative intent, prior laser photoresection, and/or concurrent external radiation. Survival was the strongest predictor of the reaction. Radiation bronchitis and stenosis is a new clinical entity that must be identified in bronchial brachytherapy patients and treated appropriately. 23 refs., 3 figs., 7 tabs

  1. Purification, crystallization and preliminary crystallographic analysis of avian infectious bronchitis virus nsp3 ADRP domain

    International Nuclear Information System (INIS)

    The crystal of the nsp3 ADRP domain of avian infectious bronchitis virus (IBV) has been obtained and subjected to further crystallograghic studies. Avian infectious bronchitis virus (IBV) encodes 15 nonstructural proteins (nsps) which play crucial roles in RNA transcription and genome replication. One of them, nsp3, contains an ADRP (adenosine diphosphate-ribose-1′-phosphatase) domain which was revealed in recent studies to have ADP-ribose-1′-monophosphatase (Appr-1′-pase) activity. Appr-1′-pase catalyzes the conversion of ADP-ribose-1′-monophosphate (Appr-1′-p) to ADP-ribose in the tRNA-splicing pathway. The gene segment encoding the IBV nsp3 ADRP domain has been cloned and expressed in Escherichia coli. The protein has been crystallized and the crystals diffracted to 1.8 Å resolution. They belonged to space group P1, with unit-cell parameters a = 41.1, b = 43.2, c = 48.9 Å, α = 78.0, β = 80.0, γ = 73.6°. Each asymmetric unit contains two molecules

  2. Crystallization and preliminary X-ray diffraction studies of infectious bronchitis virus nonstructural protein 9

    International Nuclear Information System (INIS)

    The gene segment encoding avian infectious bronchitis virus nonstructural protein 9 has been cloned and expressed in Escherichia coli. The protein has been crystallized and the crystals diffracted X-rays to 2.44 Å resolution. Avian infectious bronchitis virus (IBV), which causes respiratory disease in infected birds, belongs to coronavirus group 3. IBV encodes 15 nonstructural proteins (nsp2–nsp16) which play crucial roles in RNA transcription and genome replication. Nonstructural protein 9 (nsp9) has been identified as a protein that is essential to viral replication because of its single-stranded RNA-binding ability. The gene segment encoding IBV nsp9 has been cloned and expressed in Escherichia coli. The protein has been crystallized and the crystals diffracted X-rays to 2.44 Å resolution. They belonged to the cubic space group I432, with unit-cell parameters a = b = c = 123.4 Å, α = β = γ = 90°. The asymmetric unit appeared to contain one molecule, with a solvent content of 62% (VM = 3.26 Å3 Da−1)

  3. [Clinical contribution of the newer fluoroquinolones in acute bacterial exacerbation of chronic bronchitis].

    Science.gov (United States)

    Niederman, M S

    1999-01-01

    Acute exacerbations occur frequently in patients with chronic bronchitis and the majority of these patients benefit from antimicrobial therapy. The ideal antimicrobial agent for the management of acute exacerbations of chronic bronchitis (AECB) should have good activity against the common bacterial pathogens associated with these exacerbations (non-typable Haemophilus influenzae, Moraxella catarrhalis and pneumococci); it should be resistant to bacterial betalactamases; penetrate well into pulmonary tissues and secretions; kill bacteria without inducing excessive airway inflammation; be easy to take (given once or twice a day) in order to ensure high patient compliance, and be cost-effective. Fluoroquinolone antibiotics have demonstrated efficacy in the treatment of AECB, but because of the limited activity of certain older agents in this class when administered in standard doses against Streptococcus pneumoniae, they have not be extensively used for this indication. Newer agents including levofloxacin, grepafloxacin, sparfloxacin and trovafloxacin have excellent activity against both Gram positive and Gram negative pathogens likely to be involved in AECB. These agents can be administered once daily, making patient compliance and a successful therapeutic outcome more likely. The new quinolones offer promising alternatives for antimicrobial therapy in outpatients with AECB, particularly those with underlying co-morbidity and severe obstruction. PMID:10436551

  4. Chronic Bronchitis

    Science.gov (United States)

    ... can increase your walking speed. You can also increase the length of time you walk to 20 minutes, then 25 minutes, then 30 minutes. Ask your doctor for help creating an exercise plan that's right for you. An exercise program called pulmonary rehabilitation may help you improve your ...

  5. Effect of sputum processing with dithiothreitol on the detection of inflammatory mediators in chronic bronchitis and bronchiectasis

    OpenAIRE

    Woolhouse, I.; Bayley, D; Stockley, R

    2002-01-01

    Background: Sputum analysis is used increasingly to assess airway inflammation in patients with chronic obstructive pulmonary disease, including those with chronic bronchitis and bronchiectasis. However, it is not known whether dithiothreitol (DTT), a reducing mucolytic agent regularly used to homogenise sputum, affects the detection of inflammatory mediators in the sputum soluble phase from such patients.

  6. Treatment of 301 Infantile Acute Bronchitis Patients withQingre Lifei (清热利肺) Oral Liquid

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    From December 1995 to May 1996, 4 hospitals in Beijing, Guangzhou and Chengdu had 301 patients with infantile acute bronchitis (IAB) treated with Qingre Lifei (清热利肺, QRLF) oral liquid and the results compared with that of similar cases treated with Shema (射麻, SM) oral liquid. Following is the report.

  7. Study on the red blood cell immuno-function and relevant cytokines levels in elderly patients with chronic bronchitis

    International Nuclear Information System (INIS)

    Objective: To explore the changes of red blood cell immuno-function and serum IL-4, IL-5, IL-8, IL-10 levels in elderly patients with chronic bronchitis. Methods: The red cell C3b receptor (RBC-C3bR) and red blood cell immune complex rosette (RBC-ICR) (with immune methods), IL-4, IL-8 levels (with RIA) and IL-10, IL-5 levels (with ELISA) were measured were measured in 48 elderly patients with chronic bronchitis and 35 controls. Results: RBC-C3bRR percentage and IL-10 levels were significantly lower in patients with chronic bronchitis than those in controls (P<0.01) while IL-4, IL-5, IL-8 levels were significantly higher (P<0.01), RBC-C3bRR was significantly negatively correlated to IL-4, IL-5 and IL-8 (r=-0.3112, -0.3415, -0. 3718, P<0.05) and RBC-ICRRR was positiviely correlated to IL-10 level (r=0.3715,P<0.05). Conclusion: The lower red cell immuno-function is closely associated with alteration of cytokines levels in elderly patients with chronic bronchitis. (authors)

  8. Comparison of the results of X-ray, endoscopic and radionuclide investigations in patients with deforming bronchitis

    International Nuclear Information System (INIS)

    Comprehensive investigation including panoramic chest X-ray, tomography, bronchofibroscopy with biopsy, bronchography, and comprehensive radionuclide investigation, were used in 233 patients with deforming bronchitis. All the patients were divided into 3 groups. Endoscopic findings corresponded to the results of comprehensive radionuclide investigation in all the groups

  9. Association of residential dampness and mold with respiratory tract infections and bronchitis: a meta-analysis

    Energy Technology Data Exchange (ETDEWEB)

    Fisk, William J.; Eliseeva, Ekaterina A.; Mendell, Mark J.

    2010-11-15

    Dampness and mold have been shown in qualitative reviews to be associated with a variety of adverse respiratory health effects, including respiratory tract infections. Several published meta-analyses have provided quantitative summaries for some of these associations, but not for respiratory infections. Demonstrating a causal relationship between dampness-related agents, which are preventable exposures, and respiratory tract infections would suggest important new public health strategies. We report the results of quantitative meta-analyses of published studies that examined the association of dampness or mold in homes with respiratory infections and bronchitis. For primary studies meeting eligibility criteria, we transformed reported odds ratios (ORs) and confidence intervals (CIs) to the log scale. Both fixed and random effects models were applied to the log ORs and their variances. Most studies contained multiple estimated ORs. Models accounted for the correlation between multiple results within the studies analyzed. One set of analyses was performed with all eligible studies, and another set restricted to studies that controlled for age, gender, smoking, and socioeconomic status. Subgroups of studies were assessed to explore heterogeneity. Funnel plots were used to assess publication bias. The resulting summary estimates of ORs from random effects models based on all studies ranged from 1.38 to 1.50, with 95% CIs excluding the null in all cases. Use of different analysis models and restricting analyses based on control of multiple confounding variables changed findings only slightly. ORs (95% CIs) from random effects models using studies adjusting for major confounding variables were, for bronchitis, 1.45 (1.32-1.59); for respiratory infections, 1.44 (1.31-1.59); for respiratory infections excluding nonspecific upper respiratory infections, 1.50 (1.32-1.70), and for respiratory infections in children or infants, 1.48 (1.33-1.65). Little effect of publication

  10. Clinical and radiological diagnosis of chronic pneumonia in pneumoconiosis and dust bronchitis

    International Nuclear Information System (INIS)

    Clinical and radiologic symptomatology of chronic pneumonia is described for pneumoconiosis and chronic dust bronchitis. Combined X-ray methods of examination permit the physicians to discover this complication in dust diseases of the lungs in the presence of diffuse pneumosclerotic changes in 76.5+-3 % of cases. These data approach the values of chronic pneumonia incidence among the population. Chronic pneumonia diagnosis should be complex. If no less than 2 to 3 X-ray signs of the disease have been found simultaneously, the significance of radiologic diagnosis of chronic pneumonia in dust pathology of the lungs, rises. Radiologic examination, supported by clinical, anamnestic and laboratory data, allows one to differentiate chronic pneumonia from coniotuberculosis. Chest X-rays in dust pathology of the lungs, complicated by chronic pneumonia, should be carried out with regard to clinical indications

  11. Radiation bronchitis in lung cancer patient treated with stereotactic radiation therapy

    International Nuclear Information System (INIS)

    We report a case of chronic radiation bronchitis that developed in a patient with lung cancer treated with fractionated stereotactic radiation therapy. A 73-year-old woman with a medically inoperable T1N0M0 adenocarcinoma of the lung was treated with stereotactic radiation therapy. By using eight non-coplanar ports, 50 Gy/5 fractions was delivered in two weeks. At four weeks, a partial response was obtained with no acute adverse reaction. She developed severe cough at six months. Fiberoptic bronchoscopy revealed thick circumferentially coated bronchial mucosa in close proximity to the tumor site. At 12 months, follow-up study confirmed marked stenotic change in the B6 segmental bronchus without tumor progression. (author)

  12. Pivmecillinam and amoxycillin as combined treatment in purulent exacerbations of chronic bronchitis.

    Science.gov (United States)

    Pines, A; Nandi, A R; Raafat, H; Rahman, M

    1977-07-01

    One hundred and thirty-two patients with purulent exacerbations of chronic bronchitis were randomly allotted to treatment in three groups. They received (a) amoxycillin 250 mg and pivmecillinam 200 mg; or (b) amoxycillin 500 mg; or (c) amoxycillin 500 mg and pivmecillinam 400 mg: three times daily for 10 days. By the 7th day of treatment there was significant improvement over amoxycillin alone for both groups given combined chemotherapy in conversion of sputum to mucoid and in general improvement; at the end of treatment results in patients given the higher doses of both antibiotics were still superior to amoxycillin alone. Patients were observed 2 to 4 weeks later, when those given amoxycillin alone relapsed much more frequently. The three treatments were well tolerated and succeeded equally in clearing potential pathogens from the sputum. Combined treatment may be superior due to synergy against Haemophilus influenzae or to the elimination of beta-lactamase producing organisms and should be investigated further. PMID:330483

  13. Detection of variant infectious bronchitis viruses in Sri Lanka (2012-2015).

    Science.gov (United States)

    Ball, Christopher; Forrester, Anne; Ganapathy, Kannan

    2016-06-01

    Poultry production is an important sector of agriculture in Sri Lanka; however, there is a lack of information regarding circulation of infectious bronchitis virus (IBV). RNA was extracted from chicken tissues, subjected to IBV S1 RT-PCR, and sequenced. Overall, 19 out of 34 (55.88 %) samples were IBV positive and contained the genotype 793B (n = 13; 68.42 %), D274 (n = 4; 21.05 %) or Massachusetts (n = 2; 10.53 %). All three genotypes contained at least one strain with less than 99 % nucleotide sequence identity to the corresponding vaccine strains. This report identified co-circulation of IBV strains 793B, Massachusetts and D274, in Sri Lanka that are divergent from the respective vaccine strains. PMID:27020570

  14. The cytoplasmic tails of infectious bronchitis virus E and M proteins mediate their interaction

    International Nuclear Information System (INIS)

    Virus-like particle (VLP) formation by the coronavirus E and M proteins suggests that interactions between these proteins play a critical role in coronavirus assembly. We studied interactions between the infectious bronchitis virus (IBV) E and M proteins using in vivo crosslinking and VLP assembly assays. We show that IBV E and M can be crosslinked to each other in IBV-infected and transfected cells, indicating that they interact. The cytoplasmic tails of both proteins are important for this interaction. We also examined the ability of the mutant and chimeric E and M proteins to form VLPs. IBV M proteins that are missing portions of their cytoplasmic tails or transmembrane regions were not able to support VLP formation, regardless of their ability to be crosslinked to IBV E. Interactions between the E and M proteins and the membrane bilayer are likely to play an important role in VLP formation and virus budding

  15. Survey on circulation of infectious bronchitis virus strains in Northern Italy

    Directory of Open Access Journals (Sweden)

    Cristian De Battisti

    2010-01-01

    Full Text Available Infectious Bronchitis (IB still causes significant health problems in the poultry industry with high economic impact. The presence of several serotypes of IB and the emergence of novel ones must be monitored in order to take appropriate action and to adapt the vaccination programmes to the prevalent serotypes. In order to establish which serotypes are circulating in densely populated poultry area (DPPA of Northern Italy, a surveillance programme has been undertaken during 2004 and 2005. The results of this surveillance programme show the active circulation of 793-B, IT-02, the introduction of a novel strain, known as QXIBV, originally identified in China and the re-emergence of previously circulating serotype as B1648.

  16. Effects of prednisone on eosinophilic bronchitis in asthma: a systematic review and meta-analysis,

    Directory of Open Access Journals (Sweden)

    Thiago Mamôru Sakae

    2014-10-01

    Full Text Available OBJECTIVE: To evaluate the effect size of oral corticosteroid treatment on eosinophilic bronchitis in asthma, through systematic review and meta-analysis. METHODS: We systematically reviewed articles in the Medline, Cochrane Controlled Trials Register, EMBASE, and LILACS databases. We selected studies meeting the following criteria: comparing at least two groups or time points (prednisone vs. control, prednisone vs. another drug, or pre- vs. post-treatment with prednisone; and evaluating parameters before and after prednisone use, including values for sputum eosinophils, sputum eosinophil cationic protein (ECP, and sputum IL-5-with or without values for post-bronchodilator FEV1-with corresponding 95% CIs or with sufficient data for calculation. The independent variables were the use, dose, and duration of prednisone treatment. The outcomes evaluated were sputum eosinophils, IL-5, and ECP, as well as post-bronchodilator FEV1. RESULTS: The pooled analysis of the pre- vs. post-treatment data revealed a significant mean reduction in sputum eosinophils (↓8.18%; 95% CI: 7.69-8.67; p < 0.001, sputum IL-5 (↓83.64 pg/mL; 95% CI: 52.45-114.83; p < 0.001, and sputum ECP (↓267.60 µg/L; 95% CI: 244.57-290.63; p < 0.0001, as well as a significant mean increase in post-bronchodilator FEV1 (↑8.09%; 95% CI: 5.35-10.83; p < 0.001. CONCLUSIONS: In patients with moderate-to-severe eosinophilic bronchitis, treatment with prednisone caused a significant reduction in sputum eosinophil counts, as well as in the sputum levels of IL-5 and ECP. This reduction in the inflammatory response was accompanied by a significant increase in post-bronchodilator FEV1.

  17. Genome sequencing and characterization analysis of a Beijing isolate of chicken corona virus infectious bronchitis virus

    Institute of Scientific and Technical Information of China (English)

    JIN Weiwu; YU Jialin; LI Ning; GONG Yuanshi; SUN Qixin; CHEN Zhangliang; CHEN Chen; ZHANG Ying; ZHAO Yiqiang; FENG Jidong; CHEN Fuyong; WU Qingming; YANG Hanchun; WANG Ming

    2004-01-01

    Avian infectious bronchitis virus (AIBV) is lassified as a member of the genus coronavirus in the family coronaviridae. The enveloped virus has a positive-sense, single-stranded RNA genome of approximately 28 kilo-bases,which has a 5′ cap structure and 3′ polyadenylation tract.The complete genome sequence of infectious bronchitis virus (IBV), Beijing isolate, was determined by cloning sequencing and primer walking. The whole genome is 27733 nucleotides in length, has ten open reading frames: 5′-orfla-orflab-s-3a-3b-e-m- 6a-6b-n-3′. Alignments of the genome sequence of IBV Beijing isolate with those of two AIBV strains and one SARS coronavirus were performed respectively. The genome sequence of IBV Beijing isolate compared with that of the IBV strain LX4 (uncompleted, 19440 bp in size) was 91.2%similarity. However, the full-length genome sequence of IBV Beijing isolate was 85.2% identity to that of IBV Strain Beaudette, and was only 50.8% homology to that of SARS coronavirus. The results showed that the genome of IBV has remarkable variation. And IBV Beijing isolate is not closely related to SARS coronavirus. Phylogenetic analyses based on the whole genome sequence, S protein, M protein and N protein, also showed that AIBV Beijing isolate is lone virus in group Ⅲ and is distant from SARS coronavirus. In conclusion, this study will contribute to the studies of diagnosis and diseases control on IBV in China.

  18. Feline aminopeptidase N is not a functional receptor for avian infectious bronchitis virus

    Directory of Open Access Journals (Sweden)

    Harbison Carole E

    2007-02-01

    Full Text Available Abstract Background Coronaviruses are an important cause of infectious diseases in humans, including severe acute respiratory syndrome (SARS, and have the continued potential for emergence from animal species. A major factor in the host range of a coronavirus is its receptor utilization on host cells. In many cases, coronavirus-receptor interactions are well understood. However, a notable exception is the receptor utilization by group 3 coronaviruses, including avian infectious bronchitis virus (IBV. Feline aminopeptidase N (fAPN serves as a functional receptor for most group 1 coronaviruses including feline infectious peritonitis virus (FIPV, canine coronavirus, transmissible gastroenteritis virus (TGEV, and human coronavirus 229E (HCoV-229E. A recent report has also suggested a role for fAPN during IBV entry (Miguel B, Pharr GT, Wang C: The role of feline aminopeptidase N as a receptor for infectious bronchitis virus. Brief review. Arch Virol 2002, 147:2047–2056. Results Here we show that, whereas both transient transfection and constitutive expression of fAPN on BHK-21 cells can rescue FIPV and TGEV infection in non-permissive BHK cells, fAPN expression does not rescue infection by the prototype IBV strain Mass41. To account for the previous suggestion that fAPN could serve as an IBV receptor, we show that feline cells can be infected with the prototype strain of IBV (Mass 41, but with low susceptibility compared to primary chick kidney cells. We also show that BHK-21 cells are slightly susceptible to certain IBV strains, including Ark99, Ark_DPI, CA99, and Iowa97 ( Conclusion We conclude that fAPN is not a functional receptor for IBV, the identity of which is currently under investigation.

  19. Serotype variation among infectious bronchitis viral isolates taken from several areas of Java

    Directory of Open Access Journals (Sweden)

    Risa Indriani

    2000-12-01

    Full Text Available Infectious bronchitis (IB is an acute highly contagious viral respiratory disease of poultry caused by virus belongs to the family of Coronaviridae. The virus consist of many serotypes with low level of cross-protectivity among serotypes. Field data showed that the outbreaks of IB were frequently reported in chicken flocks, although vaccinations against the disease have been practiced. Hence, the study on serotype relationship among isolates of the viruses is essentially required. The aim of this study was to isolate and characterize IB viruses from chicken flocks in some areas of Java. Isolation of the virus was carried out in nine-day old embrionated chicken eggs and identified by means of agar gel precipitation (AGP tests against standard antisera to IB virus. The serotypes of the IB viral isolates were determined by cross-neutralization tests in nine day old embryonated chicken eggs using r value derived from homologous and heterologous serum titres as criteria. This study obtained 12 IB viral isolates which were identified on the basis of the ability to cause lesions in chicken embryos and positive to agar gel presipitation test against standard positive antiserum to the virus. Based on the cross-neutralization tests in embryonated chicken eggs, isolate I.9 was formed to have relationship closed to Mass-41 serotype, while I.2, I. 3, and I.7 isolates were closely to the serotype of Con-46. Virus isolates (I.5, I.14, I.24, and I.25 were decided to have no serotype relationships to either Mass-41 or Con-46 serotype. Since the I.5, I.14, I.24 and I.25 isolates were not neutralized by antisera against the previous identified local infectious bronchitis viral isolates, and that were considered to be distinct serotype to the previously identified local IB viral isolates.

  20. Prevalence of Asthma, COPD, and Chronic Bronchitis in Iran: A Systematic Review and Meta-analysis.

    Science.gov (United States)

    Varmaghani, Mehdi; Farzadfar, Farshad; Sharifi, Farshad; Rashidian, Arash; Moin, Mostafa; Moradi-Lakeh, Maziar; Rahimzadeh, Shadi; Saeedi Moghaddam, Sahar; Kebriaeezadeh, Abbas

    2016-04-01

    In this study, we aimed to conduct a meta-analysis on the results of eligible studies to estimate the prevalence of asthma, COPD, and Chronic bronchitis in Iran. International and Iranian databases including PubMed, Scopus, Web of Science, Iranmedex, and scientific information database (SID) were searched for population-based studies that had reported the prevalence of asthma and COPD from 1990 to 2015. We conducted the meta-analysis using metaprop application of Stata statistical software. I-Squared was used for calculating heterogeneity among the studies. To determine causes of heterogeneity, subgroup analysis and meta-regression method were used. Based on the results of random effect method, the overall prevalence of asthma ever was 4.56% (3.76%-5.36%) among men while it was 4.17% (3.42%-4.91%) among women. Pooled prevalence of current asthma was 7.95% while confidence interval changed from 5.85% to 10.06% (men 5.83% (2.75%-8.92%), women 9.13% (3.35%-14.94%)). Also based on the results of random effect model pooled prevalence of chronic bronchitis of five studies was 5.57%. It seems that the total crude prevalence of current asthma in Iran is less than many other countries such as Kuwait, Lebanon, Thailand, Japan, Australia and Germany and is higher than some other countries such as Oman, Pakistan, South Korea, India, China, Taiwan, Indonesia, Spain, Russia, and Greece. On the other hand, Iran is in middle situation in terms of the prevalence current asthma. Our results can fill the information and knowledge gaps about the status of the prevalence of respiratory diseases in Iran. PMID:27090362

  1. Treatment of Cough and Dyspnea due to Acute Bronchitis by Plaster for Cough and Dyspnea-A Report of 735 Cases

    Institute of Scientific and Technical Information of China (English)

    陈振甫; 周文秀; 高举先; 孙江桥

    2002-01-01

    @@ In the light of the theory of treating the internal disease externally, an externally used plaster for treating cough and dyspnea due to acute bronchitis (Ke Chuan Yi Tie Kang 咳喘一贴康) was successfully applied to 735 cases of acute bronchitis (the treatment group), with the other 423 cases treated with routine western drugs as controls. The results showed that the cure rate in the treatment group was significantly higher than that in the control group (P<0.01); and that in the treatment group, the cure rate for the wind-cold type of acute bronchitis was significantly higher than that for the wind-heat type of acute bronchitis (P<0.01).

  2. Combined 133Xe/99mTc-HAM lung scan in children with recurrent and chronic bronchitis

    International Nuclear Information System (INIS)

    A total of 117 children with recurrent and chronic bronchitis aged from 2 months to 16 years were subjected to combined ventilation-perfusion scan of the lungs with 133Xe gas and 99mTc-HAM (human albumin microspheres). It served as a screening before bronchological examination with the aim to get a more exact indication for bronchography which leads to a higher stress in children because of anaesthesia and radioscopy. Due to combined lung scan, the number of bronchological examinations could be reduced from 109 in 1984 to 79 in 1985 and even to 54 in 1986. Among the 117 children suffering from bronchitis, normal scans in 16 cases, perfusion defects in 59 cases, combined ventilation-perfusion defects in 41 cases were found and one case showed a pure ventilation defect. The lung scan should be applied in the framework of bronchopulmonary standard diagnosis. (author)

  3. Proteomic analysis of chicken embryonic trachea and kidney tissues after infection in ovo by avian infectious bronchitis coronavirus

    OpenAIRE

    Cao, Zhongzan; Han, Zongxi; Shao, Yuhao; Geng, Heyuan; Kong, Xiangang; Liu, Shengwang

    2011-01-01

    Background Avian infectious bronchitis (IB) is one of the most serious diseases of economic importance in chickens; it is caused by the avian infectious coronavirus (IBV). Information remains limited about the comparative protein expression profiles of chicken embryonic tissues in response to IBV infection in ovo. In this study, we analyzed the changes of protein expression in trachea and kidney tissues from chicken embryos, following IBV infection in ovo, using two-dimensional gel electropho...

  4. Add-on treatment with nebulized hypertonic saline in a child with plastic bronchitis after the Glenn procedure*, **

    OpenAIRE

    Lis, Grzegorz; Cichocka-Jarosz, Ewa; Jedynak-Wasowicz, Urszula; Glowacka, Edyta

    2014-01-01

    Plastic bronchitis (PB), although a rare cause of airway obstruction, has mortality rates up to 50% in children after Fontan-type cardiac surgery. We present the case of an 18-month-old female patient with PB following pneumonia. At 6 months of age, the patient underwent the Glenn procedure due to functionally univentricular heart. Fiberoptic bronchoscopy revealed complete blockage of the left bronchus by mucoid casts. Pharmacotherapy consisted of glucocorticosteroids, azithromycin, and enala...

  5. Proteomic analysis of chicken embryonic trachea and kidney tissues after infection in ovo by avian infectious bronchitis coronavirus

    OpenAIRE

    Kong Xiangang; Geng Heyuan; Shao Yuhao; Han Zongxi; Cao Zhongzan; Liu Shengwang

    2011-01-01

    Abstract Background Avian infectious bronchitis (IB) is one of the most serious diseases of economic importance in chickens; it is caused by the avian infectious coronavirus (IBV). Information remains limited about the comparative protein expression profiles of chicken embryonic tissues in response to IBV infection in ovo. In this study, we analyzed the changes of protein expression in trachea and kidney tissues from chicken embryos, following IBV infection in ovo, using two-dimensional gel e...

  6. Efficacy of Add-on Montelukast in Nonasthmatic Eosinophilic Bronchitis: The Additive Effect on Airway Inflammation, Cough and Life Quality

    OpenAIRE

    Bao, Wuping; Liu, Ping; Qiu, Zhongmin; Yu, Li; Hang, Jingqing; Gao, Xiaohua; Zhou, Xin

    2015-01-01

    Background: The efficacy of montelukast (MONT), a cysteinyl leukotriene receptor antagonist, in nonasthmatic eosinophilic bronchitis (NAEB), especially its influence on cough associated life quality is still indefinite. We evaluated the efficacy of MONT combined with budesonide (BUD) as compared to BUD monotherapy in improving life quality, suppressing airway eosinophilia and cough remission in NAEB. Methods: A prospective, open-labeled, multicenter, randomized controlled trial was conducted....

  7. Efficacy of Add-on Montelukast in Nonasthmatic Eosinophilic Bronchitis: The Additive Effect on Airway Inflammation, Cough and Life Quality

    OpenAIRE

    Wuping Bao; Ping Liu; Zhongmin Qiu; Li Yu; Jingqing Hang; Xiaohua Gao; Xin Zhou

    2015-01-01

    Background: The efficacy of montelukast (MONT), a cysteinyl leukotriene receptor antagonist, in nonasthmatic eosinophilic bronchitis (NAEB), especially its influence on cough associated life quality is still indefinite. We evaluated the efficacy of MONT combined with budesonide (BUD) as compared to BUD monotherapy in improving life quality, suppressing airway eosinophilia and cough remission in NAEB. Methods: A prospective, open-labeled, multicenter, randomized controlled trial was conduc...

  8. Synthesis of coronavirus mRNAs: kinetics of inactivation of infectious bronchitis virus RNA synthesis by UV light

    International Nuclear Information System (INIS)

    Infection of cells with the avian coronavirus infectious bronchitis virus results in the synthesis of five major subgenomic RNAs. These RNAs and the viral genome form a 3' coterminal nested set. We found that the rates of inactivation of synthesis of the RNAs by UV light were different and increased with the length of the transcript. These results show that each RNA is transcribed from a unique promoter and that extensive processing of the primary transcripts probably does not occur

  9. Role of Atypical Pathogens and the Antibiotic Prescription Pattern in Acute Bronchitis: A Multicenter Study in Korea.

    Science.gov (United States)

    Park, Sunghoon; Oh, Kil Chan; Kim, Ki-Seong; Song, Kyu-Tae; Yoo, Kwang Ha; Shim, Yun Su; Lee, Young Ju; Lee, Myung Goo; Yun, Jang Uk; Kim, Hyun Su; Kim, Yee Hyung; Lee, Won Jun; Kim, Do Il; Cha, Hyung Gun; Lee, Jae-Myung; Seo, Jung San; Jung, Ki-Suck

    2015-10-01

    The role of atypical bacteria and the effect of antibiotic treatments in acute bronchitis are still not clear. This study was conducted at 22 hospitals (17 primary care clinics and 5 university hospitals) in Korea. Outpatients (aged ≥ 18 yr) who had an acute illness with a new cough and sputum (≤ 30 days) were enrolled in 2013. Multiplex real-time polymerase chain reaction (RT-PCR) was used to detect five atypical bacteria. A total of 435 patients were diagnosed as having acute bronchitis (vs. probable pneumonia, n = 75), and 1.8% (n = 8) were positive for atypical pathogens (Bordetella pertussis, n = 3; B. parapertussis, n = 0; Mycoplasma pneumoniae, n = 1; Chlamydophila pneumoniae, n = 3; Legionella pneumophila, n = 1). Among clinical symptoms and signs, only post-tussive vomiting was more frequent in patients with atypical pathogens than those without (P = 0.024). In all, 72.2% of the enrolled patients received antibiotic treatment at their first visits, and β-lactams (29.4%) and quinolones (20.5%) were the most commonly prescribed agents. In conclusion, our study demonstrates that the incidence of atypical pathogens is low in patients with acute bronchitis, and the rate of antibiotic prescriptions is high. PMID:26425041

  10. CLINICAL OBSERVATION ON TREATMENT OF ACUTE BRONCHITIS PRIMARILY WITH PRICKING-CUPPING ON BACK-SHU POINTS

    Institute of Scientific and Technical Information of China (English)

    XU Wei-dong; ZHANG Yong-juan; YANG Jie; CHEN Xiao-xiang; LIU Yong-xiang

    2006-01-01

    Objective: To observe the clinical effect of treatment of acute bronchitis primarily with prickingcupping method on Back-shu points. Methods: The patients of acute bronchitis were randomly divided into 2groups. In the observation group, there were 36 cases, who were treated with the integrated traditional Chinese and western medicine, primarily the pricking-cupping method on Back-shu points; while in the control group, there were 29 cases who were given the conventinal treatment of western medicine. All the 2 groups were treated for 7 days as one treating course. Results: The total effective rate of the observation group was 97.2% while that of the control group was 82.8%, so there is a significant difference between them. On the first and third days the clinical manifestations were more satisfactorily improved in the treatment group than in the control group (P < 0.01 ) and on the fifth and seventh days, the comparison showed no significant difference (P >0.05). Conclusion: The treatment of acute bronchitis by means of the integrated traditional Chinese and western medicine primarily with pricking-cupping method on Back-shu points is of marked therapeutic effect, simple manipulation, and little untoward effects, thus claiming the unique advantage.

  11. Molecular detection of infectious bronchitis and avian metapneumoviruses in Oman backyard poultry.

    Science.gov (United States)

    Al-Shekaili, Thunai; Baylis, Matthew; Ganapathy, Kannan

    2015-04-01

    Infectious bronchitis virus (IBV) and avian metapneumovirus (aMPV) are economically important viral pathogens infecting chickens globally. Identification of endemic IBV and aMPV strains promotes better control of both diseases and prevents production losses. Orophrayngeal swab samples were taken from 2317 birds within 243 different backyard flocks in Oman. Swabs from each flock were examined by RT-PCR using part-S1 and G gene primers for IBV and aMPV respectively. Thirty-nine chicken flocks were positive for IBV. Thirty two of these were genotyped and they were closely related to 793/B, M41, D274, IS/1494/06 and IS/885/00. 793/B-like IBV was also found in one turkey and one duck flock. Five flocks were positive for aMPV subtype B. Though no disease was witnessed at the time of sampling, identified viruses including variant IBV strains, may still pose a threat for both backyard and commercial poultry in Oman. PMID:25613085

  12. Complete genomic sequence analysis of infectious bronchitis virus Ark DPI strain and its evolution by recombination

    Directory of Open Access Journals (Sweden)

    Gelb Jack

    2008-12-01

    Full Text Available Abstract An infectious bronchitis virus Arkansas DPI (Ark DPI virulent strain was sequenced, analyzed and compared with many different IBV strains and coronaviruses. The genome of Ark DPI consists of 27,620 nucleotides, excluding poly (A tail, and comprises ten open reading frames. Comparative sequence analysis of Ark DPI with other IBV strains shows striking similarity to the Conn, Gray, JMK, and Ark 99, which were circulating during that time period. Furthermore, comparison of the Ark genome with other coronaviruses demonstrates a close relationship to turkey coronavirus. Among non-structural genes, the 5'untranslated region (UTR, 3C-like proteinase (3CLpro and the polymerase (RdRp sequences are 100% identical to the Gray strain. Among structural genes, S1 has 97% identity with Ark 99; S2 has 100% identity with JMK and 96% to Conn; 3b 99%, and 3C to N is 100% identical to Conn strain. Possible recombination sites were found at the intergenic region of spike gene, 3'end of S1 and 3a gene. Independent recombination events may have occurred in the entire genome of Ark DPI, involving four different IBV strains, suggesting that genomic RNA recombination may occur in any part of the genome at number of sites. Hence, we speculate that the Ark DPI strain originated from the Conn strain, but diverged and evolved independently by point mutations and recombination between field strains.

  13. Progress and Challenges toward the Development of Vaccines against Avian Infectious Bronchitis

    Directory of Open Access Journals (Sweden)

    Faruku Bande

    2015-01-01

    Full Text Available Avian infectious bronchitis (IB is a widely distributed poultry disease that has huge economic impact on poultry industry. The continuous emergence of new IBV genotypes and lack of cross protection among different IBV genotypes have been an important challenge. Although live attenuated IB vaccines remarkably induce potent immune response, the potential risk of reversion to virulence, neutralization by the maternal antibodies, and recombination and mutation events are important concern on their usage. On the other hand, inactivated vaccines induce a weaker immune response and may require multiple dosing and/or the use of adjuvants that probably have potential safety risks and increased economic burdens. Consequently, alternative IB vaccines are widely sought. Recent advances in recombinant DNA technology have resulted in experimental IB vaccines that show promise in antibody and T-cells responses, comparable to live attenuated vaccines. Recombinant DNA vaccines have also been enhanced to target multiple serotypes and their efficacy has been improved using delivery vectors, nanoadjuvants, and in ovo vaccination approaches. Although most recombinant IB DNA vaccines are yet to be licensed, it is expected that these types of vaccines may hold sway as future vaccines for inducing a cross protection against multiple IBV serotypes.

  14. Replication of Infectious Bronchitis Virus in the Chicken Mesenchymal Stem Cells

    Directory of Open Access Journals (Sweden)

    M.H. Mohammed

    2012-06-01

    Full Text Available The susceptibility of the chicken mesenchymal stem cells to infectious bronchitis virus was characterized after twenty consecutive passages in chicken mesenchymal stemm cells. Virus replication was monitored by cytopathic observation, indirect immunoperoxidase, and reverse transcription polymerase chain reaction. At 72 h post-infection (p.i. in third passage, the cytopathic effect was characterized by rounding up of cell, monolayer detachment, intracytoplasmic brownish colouration was readily observed by from 24h p.i in third passage, and at all times the extracted viral RNA from IBV-infected monolayers was demonstrated by reverse transcription polymerase chain reaction. Tissue culture effective dose50 was used to measure virus titration performed on chicken mesenchymal stem cells and the titres in twenty passages was 108.6 TID50/ml. The results obtained in this study suggested that the chicken mesenhymal stem cells can be used for adaptation IBV and may be considered a step forward for the use of these cells in the future for IBV vaccine production

  15. S1 gene-based phylogeny of infectious bronchitis virus: An attempt to harmonize virus classification.

    Science.gov (United States)

    Valastro, Viviana; Holmes, Edward C; Britton, Paul; Fusaro, Alice; Jackwood, Mark W; Cattoli, Giovanni; Monne, Isabella

    2016-04-01

    Infectious bronchitis virus (IBV) is the causative agent of a highly contagious disease that results in severe economic losses to the global poultry industry. The virus exists in a wide variety of genetically distinct viral types, and both phylogenetic analysis and measures of pairwise similarity among nucleotide or amino acid sequences have been used to classify IBV strains. However, there is currently no consensus on the method by which IBV sequences should be compared, and heterogeneous genetic group designations that are inconsistent with phylogenetic history have been adopted, leading to the confusing coexistence of multiple genotyping schemes. Herein, we propose a simple and repeatable phylogeny-based classification system combined with an unambiguous and rationale lineage nomenclature for the assignment of IBV strains. By using complete nucleotide sequences of the S1 gene we determined the phylogenetic structure of IBV, which in turn allowed us to define 6 genotypes that together comprise 32 distinct viral lineages and a number of inter-lineage recombinants. Because of extensive rate variation among IBVs, we suggest that the inference of phylogenetic relationships alone represents a more appropriate criterion for sequence classification than pairwise sequence comparisons. The adoption of an internationally accepted viral nomenclature is crucial for future studies of IBV epidemiology and evolution, and the classification scheme presented here can be updated and revised novel S1 sequences should become available. PMID:26883378

  16. Molecular Characteristics of S1 Gene of Infectious Bronchitis Virus Isolated from Chicken Proventriculus

    Institute of Scientific and Technical Information of China (English)

    CHENG Li-qin; ZHOU Ji-yong; John Dikki; SHEN Xing-yan; CHEN Ji-gang; ZHANG De-yong

    2003-01-01

    Infectious bronchitis virus was isolated from swollen proventriculi of clinically ill chicken. Thesuspected virus samples (2/97, 3/97, 1/98) were adapted in SPF chicken embryos for virus isolation andidentification. All the virus isolates were able to agglutinate chicken erythrocytes after treatment with trypsin,and interfer with the reproduction of Newcastle disease virus in chicken embryos, and have low antigenic relat-edness values with reference positive IBV. The isolates 2/97, 3/97, 1/98 RNAs extracted from the allantoicfluid of inoculated embryonated eggs were converted to cDNA by reverse transcription with 3'-primer of S1gene of (IBV). Polymerase chain reaction (PCR) was performed with two primers which span the S1 gene.Amplified product of 1.93 kb was subjected to EcoR Ⅰ and BamH Ⅰ digestion and the fragments obtainedwere the same as expected size. The PCR product was ligated to pBlueScript-SK (+) vector, and its nucleotidesequence was determined by the dideoxy-mediated chain termination method. Nucleotide sequence analysisshowed 73.6 - 99.7 % homology between the isolated IBV and the IBV strains in GenBank. The homology ofamino acid was 71.4 - 99.4 %.

  17. Tracheobronchial clearance and Beta-adrenoceptor stimulation in patients with chronic bronchitis

    International Nuclear Information System (INIS)

    The effect of a β-adrenoceptor stimulating agent, terbutaline, on mucociliary transport in the lungs was studied in 10 patients with chronic bronchitis. Mucociliary transport was studied by having the patients inhale 6μm teflon particles tagged with sup(99m)Tc and by external measurement of the radioactivity in the lungs in the supine position. Terbutaline 0.25 mg and vehicle respectively were given subcutaneously in a cross-over double-blind study. On the average, clearance was slow in the examinations where the patients were given vehicle. Terbutaline produced a marked increase in mucociliary transport in four patients, a smaller increase in one and no effect in the others. Three out of the four patients who showed a marked increase in clearance had less ventilatory impairment than the other seven patients. This may indicate that the mucociliary transport mechanism is less severely damaged in relatively early stages of the disease than in later stages. On the average FEVsub(1.0) deteriorated significantly during the clearance measurements when vehicle was given, but did not change significantly when terbutaline was given. (author)

  18. Bronchial brush biopsies for studies of epithelial inflammation in stable asthma and nonobstructive chronic bronchitis.

    Science.gov (United States)

    Riise, G C; Andersson, B; Ahlstedt, S; Enander, I; Söderberg, M; Löwhagen, O; Larsson, S

    1996-08-01

    Recently, bronchial brush biopsy (BBB) has been introduced as a complimentary method to bronchial forceps biopsy for the study of bronchial epithelial cells. We wanted to determine whether epithelial inflammatory cells in bronchial brush biopsies can reflect mucosal inflammation assessed indirectly by levels of cellular activation markers in bronchial lavage fluid. We studied 15 healthy controls, 11 asthmatics with regular steroid inhalation therapy, 13 asthmatics without steroids, and 10 smokers with nonobstructive chronic bronchitis. Differential counts of epithelial and inflammatory cells were made from the BBB material. Bronchial lavage levels of eosinophil cationic protein (ECP), myeloperoxidase (MPO), tryptase, hyaluronan and interleukin-8 (IL-8) were measured as indirect markers for inflammatory cell activation. We found an increased percentage of eosinophil granulocytes in the BBB from the steroid-untreated asthmatic patients (1.16%) in comparison to the other groups (0.11%, 0.09% and 0.02%, respectively; pairways disease. These changes appear to relate to the degree of inflammatory activity and disease severity in asthma. PMID:8866592

  19. Diagnostic and clinical observation on the infectious bronchitis virus strain Q1 in Italy

    Directory of Open Access Journals (Sweden)

    Anna Toffan

    2013-12-01

    Full Text Available This paper describes the diagnostic and clinical observations of an infectious bronchitis virus (IBV variant, referred to as Q1, in clinically ill chickens in Italy. This IBV variant was described for the first time in 1998 in China. In the autumn of 2011 it caused a small-scale epidemic in non-vaccinated meat chickens in farms located in Northern Italy. The disease was characterized by increased mortality, kidney lesions and proventriculitis. Histopatological observations confirmed the nephritis and described an unusual erosive/necrotic proventriculitis with infiltration of lymphocytes, plasma cells and heterophils, as well as fibroplasia in the lamina propria. Despite these findings and the isolation of the Q1 IB virus directly from proventricular tissue, further studies are necessary to confirm the role of this IBV strain in the development of proventricular lesions. Phylogenetic analysis revealed that all the IBV isolates were very similar and probably had a common origin. The IBV Q1 variant appears to be now endemic in the North of Italy and at times it is detected in vaccinated backyard and commercial broiler farms. The importance of continuous monitoring in controlling the spread of known or emerging IBV variants is underlined.

  20. TRYPSIN-INDUCED HEMAGGLUTINATION ASSAY FOR THE DETECTION OF INFECTIOUS BRONCHITIS VIRUS

    Directory of Open Access Journals (Sweden)

    M. S. Mahmood, M. Siddique, I. Hussain and A. Khan1

    2004-04-01

    Full Text Available A trypsin-induced hemagglutination (THA assay was standardized to detect infectious bronchitis virus (IBV in allantoic fluid (AF of embryonated eggs. The test was used in 20 samples, each collected from 5 different layer farms suspected for IBV. Allantoic fluid from inoculated embryos was harvested and treated with reagent grade trypsin at the percentages of 0.25, 0.50, 1.0 and 2.0 for 30 minutes to 3 hours at pH 7.2. The IBV in trypsinized AF was identified by clear and consistent agglutination of chicken red blood cells within 5 minutes of incubation at 37oC. The results indicated that AF treated with equal volume of 1.0% reagent grade trypsin elicited the hemagglutinating (HA activity in 3.0 hours whereas 2.0% reagent grade trypsin elicited the HA activity only after 30 minutes incubation at 37oC. Sensitivity of THA was 92% as compared with 76% for agar gel precipitation test. Gross pathological lesions (curling and dwarfing in chick embryo, intracereberal inoculation of un-weaned mice and pathogenicity test in one-day-old broiler chicks showed 79, 84 and 77% sensitivity, respectively.

  1. Lung scintigraphy in the assessment of recurrent bronchitis and pneumonia in children

    International Nuclear Information System (INIS)

    Recurrent bronchitis and pneumonia in childhood are a significant factor in predisposing adults to chronic respiratory disease. Lung scintigraphy in children with recurrent respiratory problems very frequently shows regional abnormalities, even in the absence of radiological sings. Structural changes, also at the histological level, are accompanied bu functional disturbances that cause lung scan abnormalities to become stable with time and are very likely responsible for persisting disease in adulthood. Moreover, any chronic respiratory condition that has been diagnosed,like cystic-fibrosis, bronchiectasis, bronchopulmonary malformations, lung fibrosis, should be assessed and followed-up by means of lung scintigraphy. Suspected radio transparent foreign-body inhalation, radiographical hypernucleus (compensatory or pathological emphysema?), functional assessment before lung surgery, suspected mucociliary function impairment, suspected interstitial pneumonia, all of the above conditions represent important indications to lung scintigraphy in children. Finally, it is wise pointing out that, in order to avoid false positive results towards the diagnosis of structural disease, any easily reversible functional impairment should be removed before the scan, by proper patient preparation: in children this is done by at least aerosol therapy with beta-agonists, local steroids and mucolytics for 1 week - 10 days

  2. The clinical significance of measurement of TXB2 and 6-K-PGF1α of plasma and broncho-alveolar lavage fluid in patients with bronchial asthma and chronic bronchitis

    International Nuclear Information System (INIS)

    In order to observe the changes in thromboxane B2(TXB2) and 6-keto-prostaglandin F1α(6-K-PGF1α) levels in bronchial asthma, asthmatic chronic bronchitis as well as simple chronic bronchitis, the TXB2 and 6-K-PGF1α levels in plasma and broncho-alveolar lavage fluid (BALF) for control and patients with bronchial asthma, asthmatic chronic bronchitis and simple chronic bronchitis, 30 in each group, were measured by radioimmunoassay. The results showed that the TXB2 and 6-K-PGF1α levels in plasma and BALF in patients of the three groups increased and those in patients with bronchial asthma increased markedly with significant difference, as compared with those in patients with chronic bronchitis (P2 and 6-K-PGF1α levels in BALF in patients with asthmatic chronic bronchitis were much higher than those in patients with simple chronic bronchitis (P2 and 6-K-PGF1α play an important role in pathogenesis of bronchial asthma and asthmatic chronic bronchitis. Consequently, the changes of the two parameters in BALF provide certain reference basis for differential diagnosis of the two types of chronic bronchitis

  3. Whether chronic bronchitis is an independent risk factor for cerebral infarction in the elderly 1:1 case paired study

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    BACKGROUND: The inflammatory reaction already becomes an important risk factor of causing acute cerebral infarction; however, the correlation between chronic bronchitis and senile cerebral infarction is still unclear.OBJECTIVE: To study whether the chronic bronchitis is the risk factor for senile cerebral infarction.DESIGN: 1:1 pair, case contrast, and risk factor study.SETTINGS: Department of Respiratory Medicine, Third Hospital of Tangshan; Department of Neurology,Affiliated Hospital of North China Coal Medical College.PARTICIPANTS: A total of 147 patients with acute cerebral infarction who were regarded as case group were selected from Department of Neurology, the Third Hospital of Tangshan from January 2004 to December 2006. All patients met the diagnostic criteria of the Fourth National Cerebrovascular Diseases Meeting. There were 87 males and 60 females, and their ages ranged from 65 to 83 years. Based on 1∶1 pair study, another 147 subjects without cerebrovascular disease were regarded as control group. Except the diseases about infection, there were 73 males and 74 females, and their ages ranged from 62 to 81 years. All subjects provided the confirm consent and agreed with the coordinate experiment.METHODS: ① Questionnaire of risk factor of cerebral infarction was designed to measure the following items: chronic bronchitis, hypertension, diabetes mellitus, hyperlipemia, coronary heart disease, primary cerebral infarction/transient ischemic attack and history of smoking. ② Cerebral infarction was regarded as the dependent variance, while chronic bronchitis, hypertension, diabetes mellitus, hyperiipemia, primary cerebral infarction/transient ischemic attack, coronary heart disease and smoking were regarded as the independent variance for multiple regression analysis.MAIN OUTCOME MEASURES: Risk factors of senile cerebral infarction.RESULTS: All 147 patients with acute cerebral infarction and 147 subjects without cerebrovascular diseases were involved in

  4. Vascular endothelial growth factor as a non-invasive marker of pulmonary vascular remodeling in patients with bronchitis-type of COPD

    Directory of Open Access Journals (Sweden)

    Nomura Saeko

    2007-03-01

    Full Text Available Abstract Background Several studies have indicated that one of the most potent mediators involved in pulmonary vascular remodeling is vascular endothelial growth factor (VEGF. This study was designed to determine whether airway VEGF level reflects pulmonary vascular remodeling in patients with bronchitis-type of COPD. Methods VEGF levels in induced sputum were examined in 23 control subjects (12 non-smokers and 11 ex-smokers and 29 patients with bronchitis-type of COPD. All bronchitis-type patients performed exercise testing with right heart catheterization. Results The mean pulmonary arterial pressure (mPAP and pulmonary vascular resistance (PVR after exercise were markedly increased in all bronchitis-type patients. However, both parameters after exercise with breathing of oxygen was significantly lower than in those with breathing of room air. To attenuate the effect of hypoxia-induced pulmonary vasoconstriction during exercise, we used the change in mPAP or PVR during exercise with breathing of oxygen as a parameter of pulmonary vascular remodeling. Change in mPAP was significantly correlated with VEGF level in induced sputum from patients with chronic bronchitis (r = 0.73, p = 0.0001. Moreover, change in PVR was also correlated with VEGF level in those patients (r = 0.57, p = 0.003. Conclusion A close correlation between magnitude of pulmonary hypertension with exercise and VEGF level in bronchitis-type patients could be observed. Therefore, these findings suggest the possibility that VEGF level in induced sputum is a non-invasive marker of pulmonary vascular remodeling in patients with bronchitis-type of COPD.

  5. Bronquitis infecciosa aviar: diagnóstico y control -Avian infectious bronchitis: diagnosis and control

    Directory of Open Access Journals (Sweden)

    Acevedo Beiras, Ana María

    2010-03-01

    Full Text Available ResumenLa bronquitis infecciosa aviar (BIA es una enfermedad que ocasiona unimpacto socio-económico severo en la industria avícola mundial. Es unaenfermedad respiratoria aguda, altamente contagiosa, caracterizadaprimariamente por signos respiratorios en los pollos en crecimiento. En las ponedoras, la sintomatología respiratoria es menor pero provoca una disminución marcada en la producción y calidad del huevo. El agente etiológico de esta enfermedad es el virus de la bronquitis infecciosa aviar, un Coronavirus del grupo 3 de la familia Coronaviridae, orden Nidovirales. El virus se replica en los tejidos del tracto respiratorio y en muchos tejidos a lo largo del tracto alimentario. Este virus puede infectar otras especies de aves además de los pollos. Los signos clínicos característicos son tos, estornudos, estertores traqueales, ojos acuosos, letargo y en los pollos, especialmente los jóvenes, se presentan descargas nasales. Estos signos son indicativos pero no tienen por sí solo valor diagnóstico y la confirmación requiere el aislamiento o la demostración directa de la presencia del virus aunque la serología puede ser útil en algunas circunstancias. El diagnóstico de laboratorio requiere el aislamiento viral y su identificación. Se emplean las técnicas de reacción en cadena de la polimerasa (RT-PCR, inhibición de la hemaglutinación (HI y ensayos inmunoenzimáticos (ELISA, así como la microscopía electrónica, anticuerpos monoclonales, virus neutralización (VN, inmunohistoquímica,ensayos de inmunofluorescencia y de inmunización desafío en pollos. Son ampliamente usadas vacunas vivas e inactivadas en el control de laenfermedad.SummaryAvian infectious bronchitis (BIA is a disease that provokes a severe socioeconomic impact in poultry world industry. It is a breathing sharp disease, highly contagious, characterized primarily for breathing signs in chickens in growth. In the egg-laying, the breathing sintomatology is

  6. Morphologic observations on respiratory tracts of chickens after hatchery infectious bronchitis vaccination and formaldehyde fumigation.

    Science.gov (United States)

    Di Matteo, A M; Soñez, M C; Plano, C M; von Lawzewitsch, I

    2000-01-01

    The histologic changes in the respiratory tracts of chickens were evaluated after hatchery fumigation with 40% formaldehyde vapors and vaccination against infectious bronchitis virus with live attenuated vaccine (Massachusetts serotype). One-day-old chickens were housed in four isolation units in controlled environmental conditions, fed and watered ad libitum, and separated into four groups: 1) fumigated and vaccinated birds (FV group); 2) nonfumigated and vaccinated birds (NFV group); 3) fumigated and nonvaccinated birds (FNV group); and 4) control group (C group). All birds were tested to be free from Mycoplasma gallisepticum and Mycoplasma synoviae. After necropsy on the first, eighth, and twenty-sixth days after birth, samples from tracheal upper portion and lungs were conventionally processed for light, scanning, and transmission electron microscopy. Tissue response was monitored by microscopic examination of trachea and lung. On the first day of observation, fumigated and vaccinated birds (FV group) showed extensively damaged tracheal epithelium with exfoliated areas and some active glands with electrodense granules, and in the lung, the primary bronchi epithelium had disorganized cilia and abundant lymphocytes, with emphysematous areas in tertiary bronchus. On day 8 after vaccination, cubical and cylindrical tracheal cell proliferation was observed, and on day 26, ciliated columnar epithelium was almost regenerated with heterophil corion infiltration, and hyaline cartilage nodules appeared in parabronchi. The nonfumigated and vaccinated birds (NFV) revealed less injury on the epithelial surface and a more rapid response to epithelial regeneration than the in only fumigated animals (FNV). The control group did not show remarkable morphologic changes. Postvaccinal and fumigation effects on the upper respiratory tract were temporary, whereas in lungs, increased emphysema, cartilage nodules in the interchange zone, and general lymphocyte infiltration had caused

  7. PREPARATION AND EVALUATION OF VITAMIN E ADJUVANTED OIL EMULSIFIED INFECTIOUS BRONCHITIS EXPERIMENTAL VACCINE

    Directory of Open Access Journals (Sweden)

    S. ALI, M. ARSHAD, M. SIDDIQUE AND M. ASHRAF

    2007-10-01

    Full Text Available The present study was conducted to prepare oil emulsified (OE infectious bronchitis (IB experimental vaccines. The vaccines were prepared using the vaccinal strain H-120 Infectious Bonchitis virus (IBV. The virus was cultivated in 9-day old embryonated eggs via allantoic cavity route. Allantoic-amniotic fluid (AAF was collected and inactivated with formalin @ 0.12%. Water in oil emulsion was prepared by adding one part of AAF to four parts of mineral oil containing water phase (Tween 80 and oil phase (Span 80 surfactants. Hydrophile lypohile balance (HLB of the emulsion was maintained at 7.0. Two oil emulsified experimental vaccines were prepared. Vaccine-I was prepared without vitamin E and Vaccine-II with vitamin E (300 mg/ml. A total of 120 day-old broiler breeder chickens were divided into 4 groups, A, B, C, and D, each having 30 birds. At the age of 21 days, experimental Vaccine-I, experimental vaccine-II and commercial IB killed (H-120 vaccine were inoculated @ 0.5 ml in the birds of groups A, B and C, respectively. Group D was maintained as nonvaccinated control. Efficacy of the vaccines was evaluated on the basis of humoral immune response (haemagglutination inhibition antibody titres against IB in the four groups. The seven weeks cumulative mean antibody titres (CMT of each group were calculated. The highest CMT was observed in group B (130, followed by group C (69, group A (58 and group D (17. Statistical analysis showed that haemagglutination inhibition (HI antibody titres in group B (vaccine- II were significantly higher than those of groups A, B and C (P< 0.05.

  8. Diverging trends of chronic bronchitis and smoking habits between 1998 and 2010

    Directory of Open Access Journals (Sweden)

    Accordini Simone

    2013-02-01

    Full Text Available Abstract Background No study has been carried out on the time trend in the prevalence of chronic bronchitis (CB in recent years, despite its clinical and epidemiological relevance. We evaluated the trend in CB prevalence during the past decade among young Italian adults. Methods A screening questionnaire was mailed to general population samples of 20–44 year-old subjects in two cross-sectional surveys: the Italian Study on Asthma in Young Adults (ISAYA (1998/2000; n = 18,873, 9 centres and the screening stage of the Gene Environment Interactions in Respiratory Diseases (GEIRD study (2007/2010; n = 10,494, 7 centres. CB was defined as having cough and phlegm on most days for a minimum of 3 months a year and for at least 2 successive years. The prevalence rates and the risk ratios (RRs for the association between CB and each potential predictor were adjusted for gender, age, season of response, type of contact, cumulative response rate, and centre. Results CB prevalence was 12.5% (95% CI: 12.1-12.9% in 1998/2000 and 12.6% (95% CI: 11.7-13.7% in 2007/2010; it increased among never smokers (from 7.6 to 9.1%, p = 0.003, current light smokers ( Conclusions Despite the significant reduction in current smoking, CB prevalence did not vary among young Italian adults. The temporal pattern of CB prevalence can only be partly explained by the increase of unemployment/premature retirement, asthma and allergic rhinitis, and suggests that other factors could have played a role.

  9. Genotyping of infectious bronchitis viruses from broiler farms in Iraq during 2014-2015.

    Science.gov (United States)

    Seger, Waleed; GhalyanchiLangeroudi, Arash; Karimi, Vahid; Madadgar, Omid; Marandi, Mehdi Vasfi; Hashemzadeh, Masoud

    2016-05-01

    Infectious bronchitis virus (IBV) is one of the most critical pathogens in the poultry industry, causing serious economic losses in all countries including Iraq. IBV has many genotypes that do not confer any cross-protection. This virus has been genotyped by sequence analysis of the S1 glycoprotein gene. A total of 100 tracheal and kidney tissue specimens from different commercial broiler flocks in the middle and south of Iraq were collected from September 2013 to September 2014. Thirty-two IBV-positive samples were selected from among the total and were further characterized by nested PCR. Phylogenetic analysis revealed that isolates belong to four groups (group I, variant 2 [IS/1494-like]; group II, 793/B-like; group III, QX-like; group IV, DY12-2-like). Sequence analysis revealed nucleotide sequence identities within groups I, II, and III of 99.68 %-100 %, 99.36 %-100 %, and 96.42 %-100 %, respectively. Group I (variant 2) was the dominant IBV genotype. One Chinese-like recombinant virus (DY12-2-like) that had not been reported in the Middle East was detected. In addition, the presence of QX on broiler chicken farms in the area studied was confirmed. This is the first comprehensive study on the genotyping of IBV in Iraq with useful information regarding the molecular epidemiology of IBV. The phylogenetic relationship of the strains with respect to different time sequences and geographical regions displayed complexity and diversity. Further studies are needed and should include the isolation and full-length molecular characterization of IBV in this region. PMID:26887967

  10. β-Blockers and All-Cause Mortality in Adults with Episodes of Acute Bronchitis: An Observational Study.

    Directory of Open Access Journals (Sweden)

    Frans H Rutten

    Full Text Available Recent observational studies suggest that β-blockers may improve long-term prognosis in patients with chronic obstructive pulmonary disease (COPD. We assessed whether β-blocker use improves all-cause mortality in patients with episodes of acute bronchitis.An observational cohort study using data from the electronic medical records of 23 general practices in the Netherlands. The data included standardized information about daily patient contacts, diagnoses, and drug prescriptions. Cox regression was applied with time-varying treatment and covariates.The study included 4,493 patients aged 45 years and older, with at least one episode of acute bronchitis between 1996 and 2006. The mean (SD age of the patients was 66.9 (11.7 years, and 41.9% were male. During a mean (SD follow up period of 7.7 (2.5 years, 20.4% developed COPD. In total, 22.7% had cardiovascular comorbidities, resulting in significant higher mortality rates than those without (51.7% vs. 12.0%, p<0.001. The adjusted hazard ratio of cardioselective β-blocker use for mortality was 0.62 (95% confidence interval [CI], 0.50-0.77, and 1.01 (95% CI 0.75-1.36 for non-selective ones. Some other cardiovascular drugs also reduced the risk of mortality, with adjusted HRs of 0.60 (95% CI 0.46-0.79 for calcium channel blockers, 0.88 (95% CI 0.73-1.06 for ACE inhibitors/angiotensin receptor blockers, and 0.42 (95% CI 0.31-0.57 for statins, respectively.Cardiovascular comorbidities are common and increase the risk of mortality in adults with episodes of acute bronchitis. Cardioselective β-blockers, but also calcium channel blockers and statins may reduce mortality, possibly as a result of cardiovascular protective properties.

  11. In Vitro and In Ovo Expression of Chicken Gamma Interferon by a Defective RNA of Avian Coronavirus Infectious Bronchitis Virus

    OpenAIRE

    Hackney, Karen; Cavanagh, Dave; Kaiser, Pete; Britton, Paul

    2003-01-01

    Coronavirus defective RNAs (D-RNAs) have been used for site-directed mutagenesis of coronavirus genomes and for expression of heterologous genes. D-RNA CD-61 derived from the avian coronavirus infectious bronchitis virus (IBV) was used as an RNA vector for the expression of chicken gamma interferon (chIFN-γ). D-RNAs expressing chIFN-γ were shown to be capable of rescue, replication, and packaging into virions in a helper virus-dependent system following electroporation of in vitro-derived T7 ...

  12. Clinical significance of determination of changes of serum SOD, TNF-α levels and T-cell subsets distribution type after treatment in pediatric patients with acute bronchitis

    International Nuclear Information System (INIS)

    Objective: To study the changes of serum SOD, TNF-α levels and T-cell subsets distribution type after treatment in pediatric patients with acute bronchitis. Methods: Serum SOD, TNF-α levels (with RIA) and T-cell subsets distribution type (with monoclonal antibody technique) were detected both before and after treatment in 39 pediatric patients with acute bronchitis as well as in 35 controls. Results: Before treatment, the serum levels of SOD, CD4/CD8 ratios were significantly lower and serum TNF-α levels significantly higher in the patients than those in the controls (P0.05). Conclusion: Determination of serum SOD, TNF-α levels and T-cell subsets distribution type is clinically meaningful in pediatric patients with acute bronchitis. (authors)

  13. Clinical significance of determination of changes of serum SOD, TNF, CRP levels and T-cell subsets distribution type after treatment in aged patients with chronic bronchitis

    International Nuclear Information System (INIS)

    Objective: To investigate the changes of serum SOD, TNF, CRP levels and T-cell subsets distribution type after treatment in aged patients with chronic bronchitis. Methods: Serum SOD, TNF levels (with RIA), CRP levels (with biochemistry) and T-cell subsets distribution type (with monoclonal antibody) were detected both before and after treatment in 42 aged patients with chronic bronchitis as well as in 35 controls. Results: Before treatment, the serum levels of SOD, CD4/CD8 ratios were significantly lower and serum TNF, CRP levels significantly higher in the patients than those in the controls (P4/CD8 ratios remained significantly higher than those in controls (P <0.05). Conclusion: Determination of serum SOD, TNF, CRP levels and T-cell subsets distribution type is clinically meaningful in aged patients with chronic bronchitis. (authors)

  14. [The rehabilitation under alpine conditions of the participants in the cleanup of the accident at the Chernobyl Atomic Electric Power Station who are ill with chronic bronchitis].

    Science.gov (United States)

    Brimkulov, N N; Abdulina, A A; Davletalieva, N E; Bakirova, A N; Karamuratov, A; Mirrakhimov, M M

    1996-01-01

    24 patients exposed to low-dose radiation after the Chernobyl accident were examined before and after 24-day treatment of chronic bronchitis in the high-altitude rehabilitation center (3200 m above the sea level) in Tien Shan. Sanogenic alpine climate improved the patients' general condition, physical performance and lung ventilation, corrected compromised immunity. After high-altitude adaptation tracheobronchial inflammation alleviated, cytologic composition and surface activity of bronchoalveolar fluid returned to normal. Therefore, high-altitude treatment of Chernobyl accident victims with chronic bronchitis is effective and can be recommended for such patients. PMID:8744100

  15. Pulmonary artery radiocardiography and rheography in the diagnosis of hemodynamic and contractile function impairments of the right ventricle in patients with obstructive bronchitis

    International Nuclear Information System (INIS)

    Radiocardiography and rheography of the pulmonary artery were used to examine impairments in hemodynamics and contractile function of the right ventricle in 40 patients with chronic obstructive bronchitis complicated with persistent hypertension. Right ventricular hemodynamic and contractile impairments were shown to be not equivalent with similar clinical and functional signs of pulmonary hypertension. This fact indicates that the use of special techiques is of practical value in the determination of right ventricular hemodynamics and myocardial contractility in patients with chronic obstructive bronchitis. Radiocardiography and rheography of the pulmonary artery are sufficiently reliable noninvasive techniques for examining the hemodynamics and contractile function of the right ventricular myocardium

  16. Purification, crystallization and preliminary X-ray analysis of nonstructural protein 2 (nsp2) from avian infectious bronchitis virus

    International Nuclear Information System (INIS)

    Nonstructural protein 2 from avian infectious bronchitis virus has been overexpressed in E. coli, purified and crystallized. Diffraction data were collected to 2.8 Å resolution. Avian infectious bronchitis virus (IBV) is a member of the group III coronaviruses, which differ from the other groups of coronaviruses in that they do not encode the essential pathogenic factor nonstructural protein 1 (nsp1) and instead start with nsp2. IBV nsp2 is one of the first replicase proteins to be translated and processed in the viral life cycle; however, it has an entirely unknown function. In order to better understand the structural details and functional mechanism of IBV nsp2, the recombinant protein was cloned, overexpressed in Escherichia coli, purified and crystallized. The crystals diffracted to 2.8 Å resolution and belonged to space group P21, with unit-cell parameters a = 57.0, b = 192.3, c = 105.7 Å, β = 90.8°. Two molecules were found in the asymmetric unit; the Matthews coefficient was 3.9 Å3 Da−1, corresponding to a solvent content of 68.2%

  17. Current asthma contributes as much as smoking to chronic bronchitis in middle age: a prospective population-based study

    Directory of Open Access Journals (Sweden)

    Dharmage SC

    2016-08-01

    Full Text Available Shyamali C Dharmage,1 Jennifer L Perret,1,2, John A Burgess,1 Caroline J Lodge,1 David P Johns,3 Paul S Thomas,4 Graham G Giles,1,5 John L Hopper,1,6 Michael J Abramson,7,8 E Haydn Walters,3,9, Melanie C Matheson1 1Allergy and Lung Health Unit, Center for Epidemiology and Biostatistics, The University of Melbourne, 2Institute for Breathing and Sleep (IBAS, Melbourne, VIC, 3“Breathe Well” Center of Research Excellence for Chronic Respiratory Disease and Lung Ageing, School of Medicine, University of Tasmania, Hobart, TAS, 4Inflammation and Infection Research, Faculty of Medicine, University of New South Wales, Sydney, NSW, 5Cancer Epidemiology Center, Cancer Council Victoria, Melbourne, VIC, Australia; 6Department of Public Health, Seoul National University, Seoul, South Korea; 7Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, 8School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 9School of Medicine, University of Tasmania, Hobart, TAS, Australia Background and objective: Personal smoking is widely regarded to be the primary cause of chronic bronchitis (CB in adults, but with limited knowledge of contributions by other factors, including current asthma. We aimed to estimate the independent and relative contributions to adult CB from other potential influences spanning childhood to middle age.Methods: The population-based Tasmanian Longitudinal Health Study cohort, people born in 1961, completed respiratory questionnaires and spirometry in 1968 (n=8,583. Thirty-seven years later, in 2004, two-thirds responded to a detailed postal survey (n=5,729, from which the presence of CB was established in middle age. A subsample (n=1,389 underwent postbronchodilator spirometry between 2006 and 2008 for the assessment of chronic airflow limitation, from which nonobstructive and obstructive CB were defined. Multivariable and multinomial logistic regression models were used to estimate

  18. Otras enfermedades obstructivas: bisinosis, bronquitis crónica y EPOC de origen laboral y bronquitis eosinofílica Other obstructive diseases: byssinosis, chronic bronchitis and occupational COPD and eosinophilic bronchitis

    Directory of Open Access Journals (Sweden)

    F. J. Michel De la Rosa

    2005-01-01

    Full Text Available Además del asma ocupacional y las enfermedades derivadas de la inhalación aguda, otras enfermedades obstructivas también reconocen un origen laboral. Aunque en la actualidad la bisinosis es una enfermedad rara en España, describimos las características de la misma por su interés histórico dentro de las enfermedades respiratorias de origen laboral y porque todavía sigue vigente en los países en vías de desarrollo. La bronquitis crónica también puede estar relacionada con la exposición laboral a polvos y humos, con frecuencia denominada "bronquitis industrial". La relación ocupacional de la EPOC ha sido más controvertida a lo largo de la historia, pero en la actualidad esta relación está aceptada; describimos la evidencia actual que sustenta esta relación. En último lugar, describimos la bronquitis eosinofílica sin asma, entidad descrita por primera vez en 1989 y que en ocasiones también puede tener un origen laboral, compartiendo agentes etiológicos con el asma ocupacional.Besides occupational asthma and diseases derived from acute inhalation, other obstructive diseases also have an occupational origin. Although at present byssinosis is a rare disease in Spain, we describe its characteristics because of its historical interest amongst occupational respiratory diseases and because it is still relevant in developing countries. Chronic bronchitis can also be related to exposure at work to dust and smoke, and is often referred to as "industrial bronchitis". Historically, the relation of CPOD to occupation has been subject to controversy, but nowadays this relationship is accepted; we describe the present evidence supporting this relationship. Finally, we describe eosinophilic bronchitis without asthma, an entity that was described for the first time in 1989 and that can sometimes have an occupational origin, sharing aetiological agents with occupational asthma.

  19. DEVELOPMENT AND EVALUATION OF A REAL-TIME TAQMAN RT-PCR ASSAY FOR THE DETECTION OF INFECTIOUS BRONCHITIS VIRUS FROM INFECTED CHICKENS

    Science.gov (United States)

    It is important to rapidly differentiate infectious bronchitis virus (IBV) from disease agents like highly pathogenic avian influenza virus and exotic Newcastle disease virus, because those diseases can be extremely similar in the early stages of their pathogenicity. In this study, we report the dev...

  20. Detection and strain differentiation of infectious bronchitis virus in tracheal tissues from experimentally infected chickens by reverse transcription-polymerase chain reaction. Comparison with an immunohistochemical technique

    DEFF Research Database (Denmark)

    Handberg, Kurt; Nielsen, O.L.; Pedersen, M.W.; Jørgensen, Poul Henrik

    1999-01-01

    Oligonucleotide pairs were constructed for priming the amplification of fragments of nucleocapsid (N) protein and spike glycoprotein (S) genes of avian infectious bronchitis virus (IBV) by reverse transcription-polymerase chain reaction (RT-PCR). One oligonucleotide pair amplified a common segment...

  1. Efficacy and safety of moxifloxacin in acute exacerbations of chronic bronchitis: a prospective, multicenter, observational study (AVANTI

    Directory of Open Access Journals (Sweden)

    Chuchalin Alexander

    2013-01-01

    Full Text Available Abstract Background Acute exacerbations of chronic bronchitis (AECB, including chronic obstructive pulmonary disease (AECOPD, represent a substantial patient burden. Few data exist on outpatient antibiotic management for AECB/AECOPD in Eastern/South Eastern Europe, in particular on the use of moxifloxacin (Avelox®, although moxifloxacin is widely approved in this region based on evidence from international clinical studies. Methods AVANTI (AVelox® in Acute Exacerbations of chroNic bronchiTIs was a prospective, observational study conducted in eight Eastern European countries in patients > 35 years with AECB/AECOPD to whom moxifloxacin was prescribed. In addition to safety and efficacy outcomes, data on risk factors and the impact of exacerbation on daily life were collected. Results In the efficacy population (N = 2536, chronic bronchitis had been prevalent for > 10 years in 31.4% of patients and 66.0% of patients had concomitant COPD. Almost half the patients had never smoked, in contrast to data from Western Europe and the USA, where only one-quarter of COPD patients are non-smokers. The mean number of exacerbations in the last 12 months was 2.7 and 26.3% of patients had been hospitalized at least once for exacerbation. Physician compliance with the recommended moxifloxacin dose (400 mg once daily was 99.6%. The mean duration of moxifloxacin therapy for the current exacerbation (Anthonisen type I or II in 83.1%; predominantly type I was 6.4 ± 1.9 days. Symptom improvement was reported after a mean of 3.4 ± 1.4 days. After 5 days, 93.2% of patients reported improvement and, in total, 93.5% of patients were symptom-free after 10 days. In the safety population (N = 2672, 57 (2.3% patients had treatment-emergent adverse events (TEAEs and 4 (0.15% had serious TEAEs; no deaths occurred. These results are in line with the known safety profile of moxifloxacin. Conclusions A significant number of patients in this

  2. Protective effect of a bacterial extract against acute exacerbation in patients with chronic bronchitis accompanied by chronic obstructive pulmonary disease

    Institute of Scientific and Technical Information of China (English)

    李靖; 郑劲平; 袁锦屏; 曾广翘; 钟南山; 林材元

    2004-01-01

    Background Immunostimulating agents made from bacterial extracts represent a class of medications that contains antigens derived from several bacterial strains and their potential ability to prevent bacterial infections results from the stimulation of the nonspecific component of the immune system. The present study investigated the effect of the oral immunostimulant Broncho-Vaxom, which includes material from eight different species of bacteria that are frequently present in the lower respiratory tract, on the frequency and severity of acute exacerbation in patients with chronic bronchitis accompanied by chronic obstructive pulmonary disease (COPD). Methods Ninety patients with chronic bronchitis complicated with COPD were randomly divided into groups A and B. Forty-nine subjects in group A received oral capsules containing 7mg Broncho-Vaxom, while 41 patients in group B received similar placebo capsules. Both groups took one capsule daily for the first 10 days of each month for 3 consecutive months. The frequency of acute exacerbation, symptom scores, and lung function were recorded for the following one year period.Results There was a significant decrease in the incidence, duration, and severity of acute exacerbation, as well as a reduction in the course of antibiotics administered and in the dosage of bronchodilator and mucolytic agent in group A, as compared to group B (P<0.05, respectively). Symptom scores for cough, sputum, dyspnea, as well as symptoms observed upon auscultation of the chest also improved significantly in group A as compared to group B (P<0.05, respectively). The bacterial clearance rate in sputum cultures from patients who received no antibiotics for the first 3 months was also significantly higher in group A compared to group B (P<0.01).Conclusions Orally administered Broncho-Vaxom is associated with a decrease in the incidence of acute exacerbation and a decrease in the need for antibiotics and symptomatic relief medications in patients

  3. Clinical efficacy of farcosolvin syrup (ambroxol–theophylline–guaiphenesin mixture in the treatment of acute exacerbation of chronic bronchitis

    Directory of Open Access Journals (Sweden)

    Mostafa Yakoot

    2010-07-01

    Full Text Available Mostafa Yakoot1, Amel Salem2, Abdel-Mohsen Omar31Green Clinics and Research Center, Alexandria, Egypt; 2Al-Mabarah Hospital, 3Faculty of Pharmacy, Alexandria University, Alexandria, EgyptBackground: Acute exacerbations of chronic bronchitis (AECB are defined as recurrent attacks of worsening bronchial inflammation that are marked by an increase in the volume of daily sputum produced, a change in color of the expectorated sputum, and worsening dyspnea. Farcosolvin® (Pharco Pharmaceuticals, Alexandria, Egypt is a mixture of ambroxol (15 mg; theophylline (50 mg; and guaiphenesin (30 mg, per 5 mL syrup.Objective: To test the clinical efficacy of Farcosolvin in the treatment of AECB in a randomized, single-blinded, controlled study design.Patients and methods: One hundred patients with AECB were randomized to either Farcosolvin or guaiphenesin treatment groups, in addition to the standard medical treatment for their cases. Baseline clinical symptomatolgy of breathlessness, cough, and sputum severity scoring were compared before and after 3 and 7 days of treatment in both groups and the differences compared between groups. Changes in perceived improvement were also compared between groups using the Clinical Global Impression of Improvement or Change Scale (CGIC.Results: There were statistically significant improvements in breathlessness and cough scores in both groups (pretreatment versus posttreatment at day 3 and at day 7; P < 0.05. There were highly statistically significant differences between groups in improvement in ­breathlessness and cough scores, after 3 and 7 days treatment, in favor of the Farcosolvin ­treatment group (P < 0.001. Out of 50 patients, 48 (96% in the Farcosolvin-treated group rated their ­improvement on the CGIC scale as “much” and “very much” improved, while only 41 patients (82% reported such a degree of improvement in the control group. The difference was statistically significant (P < 0.05.Conclusion: We

  4. Diagnosis of Infectious Bronchitis Disease in Broiler Chickens by Serological Test (ELISA and RT-PCR in Duhok

    Directory of Open Access Journals (Sweden)

    Dyar Adil Morad AL-Barwary

    2012-02-01

    Full Text Available Infectious Bronchitis (IB is one of the most important viral diseases of poultry and it causes major economic losses in poultry industry. The study was conducted to detect Infectious Bronchitis virus (IBV in broilers chicken farms in Duhok Governorate. To achieve this goal two tests have been used throughout the study protocol Enzyme-Linked Immunosorbent Assay (ELISA and Reverse Transcription Polymerase Chain Reaction (RT-PCR. One hundred and eighty Serum samples were collected from 11 chicken farms including (120 samples from 9 symptomatic non vaccinated chicken farms, (30 samples from one asymptomatic vaccinated chicken farm and another (30 samples from one asymptomatic non vaccinated chicken farm and screened for the presence of IBV antibodies by ELISA kit. The total RNAs were extracted from tracheal tissues using RNX TM-Plus reagent (Cinnagen,Iran. Eighty serum samples were positive: 50/120 (41.6% sample were symptomatic non vaccinated, another 30/30 (100% were asymptomatic vaccinated chickens samples, and the remaining samples (100 were negative by ELISA , including 70 /120 (58.4% from symptomatic non vaccinated chickens, and 30/30 (100% from asymptomatic non vaccinated chickens. The molecular detection of avian infectious bronchitis virus by use of RT-PCR was applied to extract RNAs from tracheal tissues. The test was performed on (80 symptomatic non vaccinated chickens and 36 vaccinated and non vaccinated chickens. Detection was performed using universal types of primers including XCE2+ and XCE2- 80 symptomatic chickens were examined by RT-PCR (50 with positive ELISA and 30 with negative ELISA results, 36 (44.4 % have detectable IBV-cDNA and the remaining 44 (55.6% did not have detectable IBVcDNA. Another 36 (18 asymptomatic vaccinated and 18 non vaccinated chickens were examined by RT-PCR, 8 (22.2% have detectable IBV-cDNA, and the remaining 28 (77.8% were negative. This study has determined the presences of IBV in flocks of Duhok

  5. Infectious bronchitis in Brazilian chickens: current data and observations of field service personnel

    Directory of Open Access Journals (Sweden)

    EN Silva

    2010-09-01

    Full Text Available The infectious bronchitis virus (IBV was detected for the first time in Brazil by Hipólito in 1957 in chickens sold life in the municipal market of Belo Horizonte, MG, when commercial poultry production was just starting in that country. The Massachusetts (Mass serotype was identified. However, the clinical disease was only observed in 1975, when poultry production was intensely growing. The extensive outbreak produced the classical condition in layers and breeders, affecting egg production and quality, whereas broilers presented respiratory and "nephritis-nephrosis" signs. The disease rapidly spread to all poultry-producing regions in the country, and in 1979, both the imports and the manufacturing of live vaccines against IB strains Mass, H120 and H52, were licensed. In 1980, inactivated vaccines were introduced. Molecular techniques, particularly PCR, started to bed in the identification of IBV. A retrospective analysis showed that, up to 1989, the main IBV strain circulating in Brazil was Mass. However, other studies shows the presence of a wide diversity of IBV strains in Brazil since the first strains were isolated, even before vaccination was introduced. Most researchers agree that the incidence of IBV different from Mass has increased, including of exclusively Brazilian genotypes, different from those described in other countries. Indeed, during the last few years, the number of genotypical variants has been much higher than that of the classical Mass serotype. Clinically, in addition of the classic presentations, atypical forms such as testicular atrophy and stones in the epidydimis associated to low fertility have been described. Serological techniques started to be used in vaccination monitoring and as a diagnostic tool. Serological response standards were developed, and have shown to be very useful to determine the expected profile in vaccination programs and when clinical disease is suspected. However, the immuno-enzymatic test

  6. Add-on treatment with nebulized hypertonic saline in a child with plastic bronchitis after the Glenn procedure

    Directory of Open Access Journals (Sweden)

    Grzegorz Lis

    2014-01-01

    Full Text Available Plastic bronchitis (PB, although a rare cause of airway obstruction, has mortality rates up to 50% in children after Fontan-type cardiac surgery. We present the case of an 18-month-old female patient with PB following pneumonia. At 6 months of age, the patient underwent the Glenn procedure due to functionally univentricular heart. Fiberoptic bronchoscopy revealed complete blockage of the left bronchus by mucoid casts. Pharmacotherapy consisted of glucocorticosteroids, azithromycin, and enalapril maleate. The child also received nebulized 3% NaCl solution, which proved to be beneficial. In children submitted to Fontan-type procedures, physicians must be alert for PB, which can be triggered by respiratory tract infection.

  7. Reverse transcription loop-mediated isothermal amplification for the rapid detection of infectious bronchitis virus in infected chicken tissues.

    Science.gov (United States)

    Chen, Hao-tai; Zhang, Jie; Ma, Yan-ping; Ma, Li-Na; Ding, Yao-zhong; Liu, Xiang-tao; Cai, Xue-peng; Ma, Li-qing; Zhang, Yong-guang; Liu, Yong-sheng

    2010-04-01

    A reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay targeting the nucleocapsid phosphoprotein gene of infectious bronchitis virus (IBV) was developed. The detection limits for the IBV RT-LAMP assay were 10(1) 50% egg infection dose (EID(50)) per 50 microl of titrated viruses and no cross-reaction of IBV RT-LAMP was found when tested with other viruses including Newcastle disease virus (NDV), avian reovirus (ARV), and infectious laryngotrachietis virus (ILTV) due to their mismatch with IBV RT-LAMP primers. A total of 187 clinical tissues samples (88 blood, 62 kidney and 37 lung) were evaluated and compared to conventional RT-PCR. The sensitivity of RT-LAMP and RT-PCR assays for detecting IBV RNA in clinical specimens was 99.5% and 98.4%, respectively. These findings showed that the RT-LAMP assay has potential usefulness for rapid and sensitive diagnosis in outbreak of IBV. PMID:19835950

  8. Sialic Acid Binding Properties of Soluble Coronavirus Spike (S1 Proteins: Differences between Infectious Bronchitis Virus and Transmissible Gastroenteritis Virus

    Directory of Open Access Journals (Sweden)

    Christine Winter

    2013-07-01

    Full Text Available The spike proteins of a number of coronaviruses are able to bind to sialic acids present on the cell surface. The importance of this sialic acid binding ability during infection is, however, quite different. We compared the spike protein of transmissible gastroenteritis virus (TGEV and the spike protein of infectious bronchitis virus (IBV. Whereas sialic acid is the only receptor determinant known so far for IBV, TGEV requires interaction with its receptor aminopeptidase N to initiate infection of cells. Binding tests with soluble spike proteins carrying an IgG Fc-tag revealed pronounced differences between these two viral proteins. Binding of the IBV spike protein to host cells was in all experiments sialic acid dependent, whereas the soluble TGEV spike showed binding to APN but had no detectable sialic acid binding activity. Our results underline the different ways in which binding to sialoglycoconjugates is mediated by coronavirus spike proteins.

  9. The detection of cytotoxic lymphocyte activity in chickens infected with infectious bronchitis virus or fowl pox virus.

    Science.gov (United States)

    Chubb, R C; Huynh, V; Law, R

    1987-01-01

    A cytotoxic lymphocyte assay, using cells that adhered to plastic as the target cells and neutral red as the indicator for lysis, was applied to chickens infected with either infectious bronchitis virus or fowl pox virus. Both target and effector cells were derived from the same bird. Cytotoxic lymphocytes were generated in birds infected with either virus. The activity was confined to cells of the spleen after initial immunisation, but could be detected in white cells from the blood after challenge at a peripheral site, with both virulent and avirulent virus strains. It is likely that the cytotoxic cells are T-lymphocytes. The cytotoxic assay system used was an economical and convenient method for chickens which overcame the need for inbred lines of birds. PMID:18766629

  10. Adjuvant Activity of Sargassum pallidum Polysaccharides against Combined Newcastle Disease, Infectious Bronchitis and Avian Influenza Inactivated Vaccines

    Directory of Open Access Journals (Sweden)

    Li-Jie Li

    2012-11-01

    Full Text Available This study evaluates the effects of Sargassum pallidum polysaccharides (SPP on the immune responses in a chicken model. The adjuvanticity of Sargassum pallidum polysaccharides in Newcastle disease (ND, infectious bronchitis (IB and avian influenza (AI was investigated by examining the antibody titers and lymphocyte proliferation following immunization in chickens. The chickens were administrated combined ND, IB and AI inactivated vaccines containing SPP at 10, 30 and 50 mg/mL, using an oil adjuvant vaccine as a control. The ND, IB and AI antibody titers and the lymphocyte proliferation were enhanced at 30 mg/mL SPP. In conclusion, an appropriate dose of SPP may be a safe and efficacious immune stimulator candidate that is suitable for vaccines to produce early and persistent prophylaxis.

  11. Elisa evaluation of the levels of antibodies against Infectious Bronchitis Virus in laying hens using egg yolk as substrate

    Directory of Open Access Journals (Sweden)

    RH Rauber

    2004-06-01

    Full Text Available The present work was carried out to compare Infectious Bronchitis Virus (IBV antibody titers in serum and egg yolk samples from laying hens. Sixty paired blood and egg samples were collected from laying hens of two farms. Serum samples were frozen, while egg yolk samples were diluted (1:500 before freezing. Serum and yolk samples were tested for the presence of IBV antibodies by indirect ELISA (commercial kit and titers were compared by a correlation test (alpha=0.05. There was a high correlation (r=0.62 between the two kinds of samples, which means that titers of IBV antibodies in the egg yolk and in serum samples are quite the same. Considering that blood collection causes deep stress that leads to economic losses, and since eggs are collected daily on the farm, results reported here are of importance to poultry production.

  12. Serum levels of mannan-binding lectin in chickens prior to and during experimental infection with avian infectious bronchitis virus

    DEFF Research Database (Denmark)

    Juul-Madsen, H.R.; Munch, M.; Handberg, Kurt;

    2003-01-01

    increase of 24%, whereas the acute phase response in chickens challenged after 12 h of rest peaked after 3.1 d with an increase of 51%. The specific antibody titer against IBV was also tested, and a difference (P <0.0091) between the two experimental groups was found with peak titer values of 6,816 and 4...... or complement activation via MBL-associated serine proteases (MASP) -1 and -2. Thus, MBL plays a major role in the first-line innate defense against pathogens. We investigated the MBL concentrations in serum during experimental infectious bronchitis virus (IBV) infections in chickens. The results......,349. However, the highest value was found in chickens inoculated after 12 h of activity. Thus, an inverse relation exists between the MBL response and the IBV specific antibody response. The ability of MBL to activate the complement cascade was tested in a heterologous system by deposition of human C4 on the...

  13. Mucociliary clearance in diffuse panbronchiolitis, pulmonary emphysema and chronic bronchitis estimated by aerosol inhalation cine-scintigraphy

    International Nuclear Information System (INIS)

    Aerosol inhalation cine-scintigraphy which is a new method for estimation of mucociliary clearance, was studied in patients with diffuse panbronchiolitis (DPB), pulmonary emphysema (PE), chronic bronchitis (CB) and normal controls. The deposition pattern of inhaled aerosols showed mainly a central pattern in PE, but mainly a peripheral pattern in DPB. According to serial observation of inhaled aerosols by cine-scintigraphy, tracheal transport of aerosol-bolus was in a cephalad direction and moved smoothly in normal controls, but transport was slow, zigzag and sometimes regurgitant in patients with PE and CB. Especially, no transport was observed in patients with DPB. Therefore, the authors considered that DPB had the worst impairment of mucociliary clearance, because of both ciliary abnormality and rheological disorders, in the diseases of respiratory tract. (author)

  14. Comparative effects of dexamethasone and bergenin on chronic bronchitis and their anti-inflammatory mechanisms based on NMR metabolomics.

    Science.gov (United States)

    Ren, Xiaolei; Ma, Shuangshuang; Wang, Juan; Tian, Simin; Fu, Xiaorui; Liu, Xinfeng; Li, Zhongfeng; Zhao, Baosheng; Wang, Xueyong

    2016-05-24

    In order to compare the effect of dexamethasone and bergenin on chronic bronchitis and to reveal their anti-inflammatory mechanisms, (1)H NMR-based metabolomics was performed to explore the potential biomarkers of the disease and study the therapeutic mechanisms of the drugs. In this study, 40 Sprague-Dawley male rats were randomly divided into 4 groups, namely control, model, dexamethasone and bergenin groups, with 10 rats in each group. Except for the control group, rats from the other three groups were exposed to tobacco smoke for 1 h d(-1) for 28 days. During the modeling, dexamethasone (0.2 mg kg(-1)) and bergenin (87 mg kg(-1)) were administered orally to dexamethasone or bergenin rats 3 h after exposure every day. On the other hand, control and model rats were intragastrically administered water. According to the results of morphometric analysis of the airway epithelium and the count of white blood cells in the bronchoalveolar lavage fluid (BALF), dexamethasone and bergenin could suppress the infiltration of inflammatory cells, inhibit the secretion of mucus, and reduce white blood cells in BALF. Serum samples from the rats' orbits were collected every week. The metabolic profiles of sera were analyzed by multivariate statistical analyses, including PCA, PLS-DA and OPLS-DA models, and 18 metabolites were identified. The dynamic fluctuations of these biomarkers in sera from different groups were detected. The results suggested that the anti-inflammatory mechanism of dexamethasone may be associated with BCAA metabolism and glycolysis while bergenin could change BCAA metabolism, glycine, serine and threonine metabolism, and glycolysis to treat chronic bronchitis. PMID:27098339

  15. Clinical significance of measurement of changes of serum IGF-II and NO levels after treatment in elderly patients with chronic bronchitis

    International Nuclear Information System (INIS)

    Objective: To study the clinical significance of changes of serum IGF-II and NO levels after treatment in elderly patients with chronic bronchitis. Methods: Serum IGF-II (with RIA) and NO (with Biochemical method) levels were measured in 42 elderly patients with chronic bronchitis both before and after treatment as well as in 30 controls. Results: Before treatment in the patients the serum IGF-II levels were significantly higher than those in controls (P<0.01), while the NO levels were significantly lower (P<0.01). After two weeks of treatment, the levels though dropped markedly, lemained higher than those in controls (P<0. 05). Conclusion: Serum IGF-II and NO levels changes could reflect the disease status as well as the progress of diseases. (authors)

  16. Proteomic analysis of chicken embryonic trachea and kidney tissues after infection in ovo by avian infectious bronchitis coronavirus

    OpenAIRE

    Kong Xiangang; Geng Heyuan; Shao Yuhao; Han Zongxi; Cao Zhongzan; Liu Shengwang

    2011-01-01

    Abstract Background Avian infectious bronchitis (IB) is one of the most serious diseases of economic importance in chickens; it is caused by the avian infectious coronavirus (IBV). Information remains limited about the comparative protein expression profiles of chicken embryonic tissues in response to IBV infection in ovo. In this study, we analyzed the changes of protein expression in trachea and kidney tissues from chicken embryos, following IBV infection in ovo, using two-dimensional gel e...

  17. Molecular detection of infectious bronchitis virus and it is relation with avian influenza virus (H9) and Mycoplasma gallisepticum from different geographical regions in Iraq

    OpenAIRE

    A.H. Al-Dabhawe; H.M. Kadhim; H.M. Samaka

    2013-01-01

    Infectious bronchitis virus (IBV), Avian influenza virus (AIV) and Mycoplasma gallisepticum (MG) have been recognized as the most important pathogens in poultry cause acute respiratory infection and serous economic problems in Iraq and many other countries all over the world. This study was conducted to investigate the distribution of these diseases in commercial chicken flocks in different geographical region in middle part of Iraq by using qPCR. Tracheal swabs and tissue specimens from trac...

  18. Traffic-related air pollution associated with prevalence of asthma and COPD/chronic bronchitis. A cross-sectional study in Southern Sweden

    Directory of Open Access Journals (Sweden)

    Nihlén Ulf

    2009-01-01

    Full Text Available Abstract Background There is growing evidence that air pollution from traffic has adverse long-term effects on chronic respiratory disease in children, but there are few studies and more inconclusive results in adults. We examined associations between residential traffic and asthma and COPD in adults in southern Sweden. A postal questionnaire in 2000 (n = 9319, 18–77 years provided disease status, and self-reported exposure to traffic. A Geographical Information System (GIS was used to link geocoded residential addresses to a Swedish road database and an emission database for NOx. Results Living within 100 m of a road with >10 cars/minute (compared with having no heavy road within this distance was associated with prevalence of asthma diagnosis (OR = 1.40, 95% CI = 1.04–1.89, and COPD diagnosis (OR = 1.64, 95%CI = 1.11–2.4, as well as asthma and chronic bronchitis symptoms. Self-reported traffic exposure was associated with asthma diagnosis and COPD diagnosis, and with asthma symptoms. Annual average NOx was associated with COPD diagnosis and symptoms of asthma and chronic bronchitis. Conclusion Living close to traffic was associated with prevalence of asthma diagnosis, COPD diagnosis, and symptoms of asthma and bronchitis. This indicates that traffic-related air pollution has both long-term and short-term effects on chronic respiratory disease in adults, even in a region with overall low levels of air pollution.

  19. Pathogenesis Progression of Avian Infectious Bronchitis Virus%鸡传染性支气管炎病毒致病机理的研究进展

    Institute of Scientific and Technical Information of China (English)

    余娟; 刘兴友; 王玲丽

    2011-01-01

    鸡传染性支气管是由鸡传染性支气管炎病毒引起鸡的一种急性高度接触性呼吸道传染病,由于病毒血清型较多,易于发生变异而难以免疫预防,成为养鸡业发展的重大阻力.文章就该病毒的致病机理方面的研究情况做一综述,为防制鸡传染性支气管炎提供科学依据.%Infectious bronchitis virus (IBV) is causative pathogen of infectious bronchitis (IB) , an acute, highly contagious respiratory disease in chickens, the infectious bronchitis virus has many serotypes and is easy to mutate, which has caused the difficulty for the disease's prevention, and impeded the development of poultry industry. This paper reviewed etiology, pathogenesis of the IBV in order to provide evidence for IB prevention and control.

  20. Cefditoren versus levofloxacin in patients with exacerbations of chronic bronchitis: serum inflammatory biomarkers, clinical efficacy, and microbiological eradication

    Directory of Open Access Journals (Sweden)

    Blasi F

    2013-02-01

    Full Text Available Francesco Blasi, Paolo Tarsia, Marco Mantero, Letizia C Morlacchi, Federico PifferDepartment of Pathophysiology and Transplantation, University of Milan, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Milan, ItalyBackground: The aim of this open-label, randomized, parallel-group pilot study was to evaluate the efficacy of cefditoren pivoxil and levofloxacin in terms of speed of reduction in inflammatory parameters, clinical recovery, and microbiological eradication.Methods: Forty eligible patients with acute exacerbation of chronic bronchitis (AECB were randomized to receive cefditoren 200 mg twice a day for 5 days (n = 20 or levofloxacin 500 mg once daily for 7 days (n = 20.Results: The inflammatory parameters which were significantly reduced at test-of-cure with respect to visit 1 were Krebs von den Lundgen-6 (KL-6 and interleukin-6. KL-6 decreased both in the overall study population (from 19 ± 11 UI/mL to 6 ± 8 UI/mL, P = 0.000 and in the cefditoren (from 19 ± 13 UI/mL to 8 ± 10 UI/mL, P = 0.006 and levofloxacin (from 19 ± 10 UI/mL to 5 ± 5 UI/mL, P = 0.000 arms. Similarly, interleukin-6 decreased both in the overall study population (from 13.35 ± 16.41 pg/mL to 3 ± 4.7 pg/mL, P = 0.000 and in the cefditoren (from 15.90 ± 19.54 pg/mL to 4.13 ± 6.42 pg/mL, P = 0.015 and levofloxacin (from 10.80 ± 12.55 pg/mL to 1.87 ± 1.16 pg/mL, P = 0.003 arms. At the end of treatment (test-of-cure, 6–9 days after drug initiation, the clinical success rate in the overall study population was 78%; the clinical cure rate was 80% in the cefditoren arm and 75% in the levofloxacin arm. Globally, bacteriological eradication at test-of-cure was obtained in 85% of the overall study population. Both treatments were well tolerated.Conclusion: Cefditoren represents a valid option in the treatment of mild to moderately severe cases of AECB in the outpatient care setting. Moreover, the use of this cephalosporin is associated with a significant

  1. Proteomic analysis of chicken embryonic trachea and kidney tissues after infection in ovo by avian infectious bronchitis coronavirus

    Directory of Open Access Journals (Sweden)

    Kong Xiangang

    2011-03-01

    Full Text Available Abstract Background Avian infectious bronchitis (IB is one of the most serious diseases of economic importance in chickens; it is caused by the avian infectious coronavirus (IBV. Information remains limited about the comparative protein expression profiles of chicken embryonic tissues in response to IBV infection in ovo. In this study, we analyzed the changes of protein expression in trachea and kidney tissues from chicken embryos, following IBV infection in ovo, using two-dimensional gel electrophoresis (2-DE coupled with matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry (MALDI-TOF-TOF MS. Results 17 differentially expressed proteins from tracheal tissues and 19 differentially expressed proteins from kidney tissues were identified. These proteins mostly related to the cytoskeleton, binding of calcium ions, the stress response, anti-oxidative, and macromolecular metabolism. Some of these altered proteins were confirmed further at the mRNA level using real-time RT-PCR. Moreover, western blotting analysis further confirmed the changes of annexin A5 and HSPB1 during IBV infection. Conclusions To the best of our knowledge, we have performed the first analysis of the proteomic changes in chicken embryonic trachea and kidney tissues during IBV infection in ovo. The data obtained should facilitate a better understanding of the pathogenesis of IBV infection.

  2. Cloning and Sequencing of S Gene of Novel Variant of Infectious Bronchitis Virus ZJ971 Isolates in China

    Institute of Scientific and Technical Information of China (English)

    ZHOU Ji-yong; CHENG Li-qin; SHEN Xing-yan; DING Hong-mei; WU Jian-xiang

    2002-01-01

    A novel proventriculopathogic variant (isolate ZJ971) of infectious bronchitis virus (IBV) was identified from enlarged proeventriculus of the sick chickens in the study. The S gene cDNA segment with 3.6 kb in length was amplified by RT-PCR with special primers from the ZJ971 viral isolate of (IBV) and cloned into plasmid pBluescript SK( + ). The recombinants containing S gene of IBV-ZJ971 isotate were identified by digestion of restriction enzyme EcoRI, BamHI and PCR amplification. The cloned S gene from isolate IBVZJ971 was composed of 3492 bp in length encoding for a polypeptide of 1080 amino acids. Comparing the nucleotide of S gene of IBV isolate ZJ971 with that of reported IBV strains Beaudette, M41, Ark99 and CuT2,the homology was 97.3%, 97.5%, 88.6% and 85.6%, respectively; and the homology of the deduced amino acids of S protein of IBV isolate ZJ971 was 96%, 96.3%, 86.1% and 83.1% respectively; especially, the mutation of 3241st nucleotide of S gene of IBV isolate ZJ971 from G to T resulted in the translating termination of S protein at 3240th nucleotide site.

  3. Ambient temperature and outpatient visits for acute exacerbation of chronic bronchitis in Shanghai: a time series analysis.

    Science.gov (United States)

    Huang, Fang; Zhao, Ang; Chen, Ren Jie; Kan, Hai Dong; Kuang, Xing Ya

    2015-01-01

    The association between ambient temperature and acute exacerbation of chronic bronchitis (AECB) was still unknown. Therefore, we performed an epidemiological study in a large hospital of Shanghai to explore the relationship about temperature and outpatient visit for AECB. We adopted a quasi-Poisson generalized additive models and distributed lag nonlinear models to estimate the accumulative effects of temperature on AECB across multiple days. We found significant non-linear effects of cold temperature on hospital visits for AECB, and the potential effect of cold temperature might last more than 2 weeks. The relative risks of extreme cold (first percentiles of temperature throughout the study period) and cold (10th percentile of temperature) temperature over lags 0-14 d were 2.98 [95% confidence intervals (CI): 1.77, 5.04] and 1.63 (95% CI: 1.21, 2.19), compared with the 25th percentile of temperature. However, we found no positive association between hospital visits and hot weather. This study showed that exposure to both extreme cold and cold temperatures were associated with increased outpatient visits for AECB in a large hospital of Shanghai. PMID:25566865

  4. ECOLOGICAL STRESS AND ITS EFFECTS ON ESSENTIAL HYPERTENSION AND CHRONIC OBSTRUCTIVE BRONCHITIS DEVELOPMENT IN ROSTOV-ON-DON INHABITANTS

    Directory of Open Access Journals (Sweden)

    L. I. Katelnitskaya

    2015-12-01

    Full Text Available Aim. To study prevalence of essential hypertension (HT and chronic obstructive bronchitis (COB among Rostov-on-Don population, to assess influence of ecological stress on HT and COB development and to find the ways to improve therapy of combined pathology.Material and methods. Single-stage epidemiologic study of Rostov-on-Don population was carried out. The study included questionnaire to reveal main risk factors of chronic noninfectious diseases, a number of laboratory and instrumental indices.Results. Prevalence of HT and COB is significantly higher in patients, living in ecologically unfavorable districts. Rigidity and stretch ability of vascular wall influence the course and development of HT as well as atrial natriuretic factor. Carbonic anhydrase inhibitor, acetazolamide, when is added to standard therapy increases in its efficacy in blood pressure control, decrease in blood pressure in pulmonary artery and correction of disturbed acidbase balance in patients with HT combined with COB.Conclusion. The connection between unfavorable ecology and HT and COB development is demonstrated. Adjuvant therapy with acetazolamide is proposed to increase in efficacy of HT and COB standard therapy.

  5. In vitro and in ovo expression of chicken gamma interferon by a defective RNA of avian coronavirus infectious bronchitis virus.

    Science.gov (United States)

    Hackney, Karen; Cavanagh, Dave; Kaiser, Pete; Britton, Paul

    2003-05-01

    Coronavirus defective RNAs (D-RNAs) have been used for site-directed mutagenesis of coronavirus genomes and for expression of heterologous genes. D-RNA CD-61 derived from the avian coronavirus infectious bronchitis virus (IBV) was used as an RNA vector for the expression of chicken gamma interferon (chIFN-gamma). D-RNAs expressing chIFN-gamma were shown to be capable of rescue, replication, and packaging into virions in a helper virus-dependent system following electroporation of in vitro-derived T7 RNA transcripts into IBV-infected cells. Secreted chIFN-gamma, under the control of an IBV transcription-associated sequence derived from gene 5 of the Beaudette strain, was expressed from two different positions within CD-61 and shown to be biologically active. In addition, following infection of 10-day-old chicken embryos with IBV containing D-RNAs expressing chIFN-gamma, the allantoic fluid was shown to contain biologically active chIFN-gamma, demonstrating that IBV D-RNAs can express heterologous genes in vivo. PMID:12719562

  6. The virion N protein of infectious bronchitis virus is more phosphorylated than the N protein from infected cell lysates

    International Nuclear Information System (INIS)

    Because phosphorylation of the infectious bronchitis virus (IBV) nucleocapsid protein (N) may regulate its multiple roles in viral replication, the dynamics of N phosphorylation were examined. 32P-orthophosphate labeling and Western blot analyses confirmed that N was the only viral protein that was phosphorylated. Pulse labeling with 32P-orthophosphate indicated that the IBV N protein was phosphorylated in the virion, as well as at all times during infection in either chicken embryo kidney cells or Vero cells. Pulse-chase analyses followed by immunoprecipitation of IBV N proteins using rabbit anti-IBV N polyclonal antibody demonstrated that the phosphate on the N protein was stable for at least 1 h. Simultaneous labeling with 32P-orthophosphate and 3H-leucine identified a 3.5-fold increase in the 32P:3H counts per minute (cpm) ratio of N in the virion as compared to the 32P:3H cpm ratio of N in the cell lysates from chicken embryo kidney cells, whereas in Vero cells the 32P:3H cpm ratio of N from the virion was 10.5-fold greater than the 32P:3H cpm ratio of N from the cell lysates. These studies are consistent with the phosphorylation of the IBV N playing a role in assembly or maturation of the viral particle

  7. Interactive mechanism between avian infectious bronchitis S1 protein T cell peptide and avian MHC I molecule.

    Science.gov (United States)

    Zhu, Feng-Zhu; Lu, Mei; Huang, Qing-Hua; Huang, Yan-Yan; Yang, Shao-Hua; Cui, Yan-Shun; Liu, Chang; Tan, Liugang; Kong, Zhengjie; Xu, Chuan-Tian

    2016-04-01

    This study aims to construct a 3D structure of the avian major histocompatibility complex (MHC)-β2M complex through homology modelling technology, perform molecular docking of the predicted infectious bronchitis virus (IBV) S1 protein potential epitope peptide Sp6 (NQFYIKLT) and the avian MHC-β2M complex, and demonstrate the interactive mechanism between Sp6 and MHC using molecular dynamical simulations. The peptide Sp6 and the non-related peptide NP89-97 (PKKTGGPIY) were used to stimulate in vitro recombinant plasmid (pCAGGS-S1) avian splenic lymphocytes. Flow cytometric results show that CD8(+) T lymphocytes reproduce stimulated by the Sp6 and the nonrelated peptide proliferate by 34.8% and 2.6%, respectively. Meanwhile, fluorescent quantitative PCR results show that the secretion of IFN-γ in avian splenic lymphocytes increases after Sp6 stimulation. These data suggest that Sp6 can induce the activated avian lymphocytes in vitro to produce CTL, which is the CTL epitope in IBV S1. PMID:26876645

  8. Efficacy of Add-on Montelukast in Nonasthmatic Eosinophilic Bronchitis: The Additive Effect on Airway Inflammation, Cough and Life Quality

    Institute of Scientific and Technical Information of China (English)

    Wuping Bao; Ping Liu; Zhongmin Qiu; Li Yu; Jingqing Hang; Xiaohua Gao; Xin Zhou

    2015-01-01

    Background:The efficacy of montelukast (MONT),a cysteinyl leukotriene receptor antagonist,in nonasthmatic eosinophilic bronchitis (NAEB),especially its influence on cough associated life quality is still indefinite.We evaluated the efficacy of MONT combined with budesonide (BUD) as compared to BUD monotherapy in improving life quality,suppressing airway eosinophilia and cough remission in NAEB.Methods:A prospective,open-labeled,multicenter,randomized controlled trial was conducted.Patients with NAEB (aged 18-75 years) were randomized to inhaled BUD (200 μg,bid) or BUD plus oral MONT (10 μg,qn) for 4 weeks.Leicester cough questionnaire (LCQ) life quality scores,cough visual analog scale (CVAS) scores,eosinophil differential ratio (Eos),and eosinophil cationic protein (ECP) in induced sputum were monitored and compared.Results:The control and MONT groups contained 33 and 32 patients,respectively,with similar baseline characteristics.Significant with-in group improvement in CVAS,LCQ scores,Eos,and ECP was observed in both groups during treatment.After 2-week treatment,add-on treatment of MONT was significantly more effective than BUD monotherapy for CVAS decrease and LCQ scores improvement (both P < 0.05).Similar results were seen at 4-week assessment (both P < 0.05).4-week add-on therapy of MONT also resulted in a higher percentage of patients with normal sputum Eos (<2.5%) and greater decrease of ECP (both P < 0.05).Conclusions:MONT combined with BUD was demonstrated cooperative effects in improvement of life quality,suppression ofeosinophilic inflammation,and cough remission in patients with NAEB.

  9. Increased expression of Interleukin-6 related to nephritis in chickens challenged with an Avian infectious bronchitis virus variant

    Directory of Open Access Journals (Sweden)

    Filipe S. Fernando

    2015-03-01

    Full Text Available A Brazilian field isolate (IBV/Brazil/PR05 of avian infectious bronchitis virus (IBV, associated with development of nephritis in chickens, was previously genotyped as IBV variant after S1 gene sequencing. The aim of this study was to evaluate the levels of IL-6 in kidneys and trachea of birds vaccinated and challenged with IBV/Brazil/PR05 strain, correlating these results with scores of microscopic lesions, specific IBV antigen detection and viral load. The up-regulation of IL-6 and the increased levels of viral load on renal and tracheal samples were significantly correlated with scores of microscopic lesions. Reduced levels of viral load were detected in kidneys of birds previously vaccinated and challenged, compared to non-vaccinated challenged group, although markedly microscopic lesions were observed for both groups. The expression of IL-6, present both in the kidney and in the tracheas, was dependent on the load of the virus present in the tissue, and the development of lesions was related with IL-6 present in the tissues. These data suggest that variant IBV/Brazil/PR05 can induce the expression of proinflammatory cytokines in a manner correlated with viral load and increased IL-6 is involved in the tissue with the influx of inflammatory cells and subsequent nephritis. This may contribute with a model to the development of immunosuppressive agents of IL-6 to prevent acute inflammatory processes against infection with IBV and perhaps other coronaviruses, as well as contribute to the understanding of the immunopathogenesis of IBV nephropatogenic strains.

  10. Differential detection of turkey coronavirus, infectious bronchitis virus, and bovine coronavirus by a multiplex polymerase chain reaction.

    Science.gov (United States)

    Loa, C C; Lin, T L; Wu, C C; Bryan, T A; Hooper, T A; Schrader, D L

    2006-01-01

    The objective of the present study was to develop a multiplex polymerase chain reaction (PCR) method for differential detection of turkey coronavirus (TCoV), infectious bronchitis coronavirus (IBV), and bovine coronavirus (BCoV). Primers were designed from conserved or variable regions of nucleocapsid (N) or spike (S) protein gene among TCoV, IBV, and BCoV and used in the same PCR reaction. Reverse transcription followed by the PCR reaction was used to amplify a portion of N or S gene of the corresponding coronaviruses. The PCR products were detected on agarose gel stained with ethidium bromide. Two PCR products, a 356-bp band corresponding to N gene and a 727-bp band corresponding to S gene, were obtained for TCoV isolates. In contrast, one PCR product of 356 bp corresponding to a fragment of N gene was obtained for IBV strains and one PCR product of 568 bp corresponding to a fragment of S gene was obtained for BCoV. There were no PCR products with the same primers for Newcastle disease virus, Marek's disease virus, turkey pox virus, pigeon pox virus, fowl pox virus, reovirus, infectious bursal disease virus, enterovirus, astrovirus, Salmonella enterica, Escherichia coli, and Mycoplasma gallisepticum. Performance of the assay with serially diluted RNA demonstrated that the multiplex PCR could detect 4.8x10(-3) microg of TCoV RNA, 4.6x10(-4) microg of IBV RNA, and 8.0x10(-2) microg of BCoV RNA. These results indicated that the multiplex PCR as established in the present study is a rapid, sensitive, and specific method for differential detection of TCoV, IBV, and BCoV in a single PCR reaction. PMID:16137773

  11. Efficacy of Add-on Montelukast in Nonasthmatic Eosinophilic Bronchitis: The Additive Effect on Airway Inflammation, Cough and Life Quality

    Directory of Open Access Journals (Sweden)

    Wuping Bao

    2015-01-01

    Full Text Available Background: The efficacy of montelukast (MONT, a cysteinyl leukotriene receptor antagonist, in nonasthmatic eosinophilic bronchitis (NAEB, especially its influence on cough associated life quality is still indefinite. We evaluated the efficacy of MONT combined with budesonide (BUD as compared to BUD monotherapy in improving life quality, suppressing airway eosinophilia and cough remission in NAEB. Methods: A prospective, open-labeled, multicenter, randomized controlled trial was conducted. Patients with NAEB (aged 18-75 years were randomized to inhaled BUD (200 μg, bid or BUD plus oral MONT (10 μg, qn for 4 weeks. Leicester cough questionnaire (LCQ life quality scores, cough visual analog scale (CVAS scores, eosinophil differential ratio (Eos, and eosinophil cationic protein (ECP in induced sputum were monitored and compared. Results: The control and MONT groups contained 33 and 32 patients, respectively, with similar baseline characteristics. Significant with-in group improvement in CVAS, LCQ scores, Eos, and ECP was observed in both groups during treatment. After 2-week treatment, add-on treatment of MONT was significantly more effective than BUD monotherapy for CVAS decrease and LCQ scores improvement (both P < 0.05. Similar results were seen at 4-week assessment (both P < 0.05. 4-week add-on therapy of MONT also resulted in a higher percentage of patients with normal sputum Eos (<2.5% and greater decrease of ECP (both P < 0.05. Conclusions: MONT combined with BUD was demonstrated cooperative effects in improvement of life quality, suppression of eosinophilic inflammation, and cough remission in patients with NAEB.

  12. Bronquite plástica em criança com talassemia alfa Plastic bronchitis in a child with thalassemia alpha

    Directory of Open Access Journals (Sweden)

    Tiago N. Veras

    2005-12-01

    Full Text Available OBJETIVO: A bronquite plástica é uma doença infreqüente na criança, sendo caracterizada por moldes ou cilindros mucofibrinosos na árvore traqueobrônquica. Faz parte do diagnóstico diferencial de crianças com insuficiência respiratória de início agudo, e o tratamento precoce é importante para a resolução do quadro. O objetivo deste relato é descrever um caso de bronquite plástica tratado com sucesso por endoscopia, em paciente portador de talassemia alfa. DESCRIÇÃO: Criança do sexo masculino, 3 anos de idade, sem antecedentes mórbidos significativos, apresentou quadro de insuficiência respiratória aguda, com achados radiológicos de atelectasia pulmonar sugestivos de aspiração de corpo estranho. Não havia sintomas respiratórios ou antecedentes de alergia ou infecções respiratórias de repetição. A realização de broncoscopia flexível, complementada por endoscopia rígida e exame anatomopatológico, evidenciou a presença de bronquite plástica. Após a realização da endoscopia, a criança evoluiu satisfatoriamente, com curva térmica afebril e extubação em 72 horas. Foram utilizadas medicações sintomáticas, sem necessidade de antimicrobianos. Dez dias após a alta, a radiografia de tórax encontrava-se normal. A talassemia alfa foi diagnosticada através da eletroforese de hemoglobina. COMENTÁRIOS: A importância clínica da bronquite plástica reside no fato de apresentar um quadro semelhante ao de outras doenças mais prevalentes, como a aspiração de corpo estranho e a asma brônquica. A suspeita do quadro recomenda a realização de endoscopia para diagnóstico e tratamento. É reconhecida a ocorrência de bronquite plástica em crianças com fibrose cística, pós-operatório de cirurgia cardíaca e anemia falciforme. No presente artigo, foi observada uma associação com talassemia alfa.OBJECTIVE: Plastic bronchitis is an unusual condition in children, associated with formation of mucofibrinous

  13. Effectiveness of anti-inflammatory treatment versus antibiotic therapy and placebo for patients with non-complicated acute bronchitis with purulent sputum. The BAAP Study protocol

    Directory of Open Access Journals (Sweden)

    Fernández Yvonne

    2011-06-01

    Full Text Available Abstract Background Acute bronchitis is one of the most prevalent respiratory infections in primary care, and in more than 90% of the cases antibiotics are prescribed, mainly when purulent expectoration is present. However, this process is usually viral in origin and the benefits of antibiotic treatment are marginal. On the other hand, in recent years bronchitis has been considered more as an inflammatory than an infectious process. Thus, the aim of this study is to evaluate the clinical effectiveness of a schedule of an oral anti-inflammatory compared with an antibiotic regimen and another group assigned to receive a placebo. Methods and design A total of 420 patients from 15 to 70 years of age with no associated comorbidity, presenting respiratory tract infection of at least one week of evolution, with cough as the predominant symptom, the presence of purulent expectoration and at least one other symptom of the respiratory tract (dyspnoea, wheezing, chest discomfort or pain, with no alternative explanation such as pneumonia, will be included in a prospective, randomised and controlled, clinical trial with placebo. The patients will be randomised to receive one of three treatments: ibuprofen, amoxycillin and clavulanic acid or placebo for 10 days. The main outcome measure is the number of days with frequent cough defined by the symptom diary with a score of 1 or more. Discussion This trial is designed to evaluate the number of days with frequent cough with anti-inflammatory treatment compared with antimicrobial treatment and placebo in previously healthy patients with a clinical picture of acute bronchitis and purulent expectoration. It is hypothesized that anti-inflammatory treatment is more effective than antibiotic treatment to reduce cough, which is the most disturbing symptom for patients with this infection. Trial registration ISRCTN07852892

  14. Analysis of allergen detection results in children with acute bronchitis%急性支气管炎患儿血清过敏原检测分析

    Institute of Scientific and Technical Information of China (English)

    朱晓莉; 陶春妃

    2016-01-01

    Objective:To detect and analyze serum allergen of 87 children with acute bronchitis. Methods:87 patients with acute bronchitis were selected for serum allergen detection, and compared with the control group of 87 normal subjects ( no special al-lergic history). Results:For the 87 cases of children with acute bronchitis, the serum allergen test positive rate was 62. 07% (54/87);while for the control group, the serum specific allergen test positive rate was 17. 24% (15/87);and the difference was statisti-cally significant (P0. 05). The most common inhaled allergen was house dust mites/dust mites, accounting for 25. 29%, while the common ingested al-lergens were cod/lobster/scallops, crab, peanut, the proportion of 13. 79%, 18. 39% and 12. 64%, separately. Conclusions: For the children with acute bronchitis, the serum allergen detection has a higher positive detection rate, and is significant for the treatment and prevention.%目的::检测分析儿童急性支气管炎的血清过敏原。方法:将87例临床诊断为急性支气管炎患儿设为急性支气管炎组,选择87例同期健康儿童作为对照组,检测比较两组研究对象的血清过敏原。结果:急性支气管炎组患儿的血清过敏原检测阳性率为62.07%(54/87),与对照组儿童的血清特异性过敏原阳性率为17.24%(15/87)比,差异有统计学意义(P0.05);吸入性过敏原阳性率较高的为屋尘螨/粉尘螨,占比25.29%;食入性过敏原阳性率较高的是鳕鱼/龙虾/扇贝、螃蟹、花生,占比分别为13.79%、18.39%、12.64%。结论:儿童急性支气管炎血清过敏原检测具有较高的阳性检出率,对治疗和预防具有重要意义。

  15. 崔应珉教授治疗慢性支气管炎经验%Experience of Professor Cui Yingmin in the Treatment of Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    张珂

    2013-01-01

    Objective:To summarize the experience of Professor Cui Yingmin in the treatment of chronic bronchitis. Methods: Based on chronic bronchitis cases treated by Professor Cui Yingmin,to analyze and summarize the dialectical thought and clinical experiences. Results: Professor Cui Yingmin regarded chronic bronchitis was deficiency for the fundamental reason and excess in manifestation, with lung,spleen and kidney for the deficiency,while phlegm and blood stasis as the manifestation. Clinical treatment was acute exacerbation of chronic,with remission and delayed treatment by stage,with the modification of Shegan Mahuang soup,Yuebi Jiazhu soup,Sanzi Yan-gqin soup, Buzhong Yiqi soup, Erchen soup, Shashen Maidong soup. The clinical curative effect was marked. Conclusion: Professor Cui Yingmin argues that chronic bronchitis is an easily relapsed and refractory disease,in clinical it should be treated by stages by taking care of the fundermental causes and manifestations, which provides some clinical reference.%目的:探讨崔应珉教授治疗慢性支气管炎经验.方法:以崔应珉教授治疗慢性支气管炎验案为依据,分析总结其辨证思路及临证经验.结果:崔应珉教授针对慢性支气管炎多为本虚标实这一特点,以肺、脾、肾三脏亏虚为本,痰浊、瘀血为标,临床施治多以急性加重期、慢性缓解期与迁延期分期论治,以射干麻黄汤、越婢加术汤、三子养亲汤、补中益气汤、二陈汤、沙参麦冬汤等灵活化裁,临床疗效显著.结论:崔应珉教授认为慢性支气管炎是一种易复发难治性疾病,临床采用分期辨治,标本兼顾,可资临床参考.

  16. FISHBURN’S METHOD: A METHOD OF DRUGS CLINICAL EFFICIENCY EVALUATION (ON THE EXAMPLE OF ANTIBIOTICS, APPLIED FOR THE TREATMENT OF ACUTE AND RECIDIVOUS OBSTRUCTIVE BRONCHITIS OF CHILDREN

    Directory of Open Access Journals (Sweden)

    O. V. Zhukova

    2015-01-01

    Full Text Available We have studied a structure of a therapy with antibiotics which is applied for patients with acute and recidivous obstructive bronchitis. We have determined a clinical efficiency of each antibiotic used. We have presented a methodology of weight coefficients calculation efficiency by the Fishburn’s method. We have also presented a method for antibiotics distribution by the levels of clinical efficiency – high, medium, and low.

  17. Hyperbaric oxygenation in the complex treatment of obstructive chronic bronchitis in patients - participants in the liquidation of Chernobyl NPP accident consequences

    International Nuclear Information System (INIS)

    Hyperbaric oxygen therapy it has been used in the program of complex treatment at 30 patients with a chronic obstructive bronchitis. The rate hyperbaric oxygen therapy has consisted of 8-10-12 sessions, depending on weight of disease and a condition of the patient. As a result of treatment with use hyperbaric oxygen therapy/ fast improvement is reached clinical condition, positive dynamics of a gas condition of arterial blood and improvement of functional parameters of pulmonary ventilations and central hemodynamics of patients and also anti-oxidant protection activity were revealed in the basic group. (authors)

  18. 自拟咳嗽方治疗急慢性支气管炎200例疗效观察%The effect of self cough decoction in the treatment of acute,chronic bronchitis in 200 cases

    Institute of Scientific and Technical Information of China (English)

    鲜晓燕; 张鲁燕

    2014-01-01

    Objective:To observe the curative effect of self cough decoction add and subtract in the treatment of acute and chronic bronchitis.Methods:200 cases of patients with acute and chronic bronchitis were used self cough decoction add and subtract treatment.Results:The total effective rate was 100%.Conclusion:The curative effect of self cough decoction in the treatment of acute and chronic bronchitis is satisfactory.%目的:观察自拟止咳方加减治疗急慢性支气管炎的疗效。方法:对200例急慢性支气管炎患者采用自拟止咳方加减治疗。结果:总有效率100%。结论:自拟止咳方治疗急慢性支气管炎疗效满意。

  19. Exposure to cold and draught, alcohol consumption, and the NS-phenotype are associated with chronic bronchitis: an epidemiological investigation of 3387 men aged 53-75 years: the Copenhagen Male Study

    OpenAIRE

    Suadicani, P; Hein, H.; H. Meyer; Gyntelberg, F

    2001-01-01

    OBJECTIVES—This study was performed to estimate the strength of association between chronic bronchitis and lifetime exposure to occupational factors, current lifestyle, and the NS-phenotype in the MNS blood group among middle aged and elderly men.
METHODS—The study was carried out within the frameworks of the Copenhagen Male Study. Of 3387 men 3331 men with a mean age of 63 (range 53-75) years could be classified by prevalence of chronic bronchitis. As well as the completion of a large questi...

  20. Evolutionary and bioinformatic analysis of the spike glycoprotein gene of H120 vaccine strain protectotype of infectious bronchitis virus from India.

    Science.gov (United States)

    Kamble, Nitin Machindra; Pillai, Aravind S; Gaikwad, Satish S; Shukla, Sanjeev Kumar; Khulape, Sagar Aashok; Dey, Sohini; Mohan, C Madhan

    2016-01-01

    The infectious bronchitis virus is a causative agent of avian infectious bronchitis (AIB), and is is an important disease that produces severe economic losses to the poultry industry worldwide. Recent AIB outbreaks in India have been associated with poor growth in broilers, drop in egg production, and thin egg shells in layers. The complete spike gene of Indian AIB vaccine strain was amplified and sequenced using a conventional reverse transcription polymerase chain reaction and is submitted to the GenBank (accession no KF188436). Phylogenetic analysis revealed that the vaccine strain currently used belongs to H120 genotype, an attenuated strain of Massachusetts (Mass) serotype. Nucleotide and amino acid sequence comparisons have shown that the reported spike gene from Indian isolates have 71.8%-99% and 71.4%-96.9% genetic similarity with the sequenced H120 strain. The study identifies live attenuated IBV vaccine strain, which is routinely used for vaccination, for the first time. Based on nucleotide and amino acid relatedness studies of the vaccine strain with reported IBV sequences from India, it is shown that the current vaccine strain is efficient in controlling the IBV infection. Continuous monitoring of IBV outbreaks by sequencing for genotyping and in vivo cross protection studies for serotyping is not only important for epidemiological investigation but also for evaluation of efficacy of the current vaccine. PMID:25311758

  1. Valuing the Economic Costs of Allergic Rhinitis, Acute Bronchitis, and Asthma from Exposure to Indoor Dampness and Mold in the US.

    Science.gov (United States)

    Mudarri, David H

    2016-01-01

    Two foundational methods for estimating the total economic burden of disease are cost of illness (COI) and willingness to pay (WTP). WTP measures the full cost to society, but WTP estimates are difficult to compute and rarely available. COI methods are more often used but less likely to reflect full costs. This paper attempts to estimate the full economic cost (2014$) of illnesses resulting from exposure to dampness and mold using COI methods and WTP where the data is available. A limited sensitivity analysis of alternative methods and assumptions demonstrates a wide potential range of estimates. In the final estimates, the total annual cost to society attributable to dampness and mold is estimated to be $3.7 (2.3-4.7) billion for allergic rhinitis, $1.9 (1.1-2.3) billion for acute bronchitis, $15.1 (9.4-20.6) billion for asthma morbidity, and $1.7 (0.4-4.5) billion for asthma mortality. The corresponding costs from all causes, not limited to dampness and mold, using the same approach would be $24.8 billion for allergic rhinitis, $13.5 billion for acute bronchitis, $94.5 billion for asthma morbidity, and $10.8 billion for asthma mortality. PMID:27313630

  2. 135例慢性支气管炎急性发作的护理%Nursing Care of 135 Cases With Acute Exacerbation of Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    苏艳镁; 张英

    2016-01-01

    Objective To investigate the nursing methods of chronic bronchial acute attack.Methods Selected 135 patients with acute exacerbation of chronic bronchitis from January 2013 to December 2014 in our hospital, given the comprehensive nursing intervention. Results The effective rate of the treatment of patients with disease was 94.8%, and the satisfaction of nursing satisfaction was 100%.Conclusion It’s important to carry out comprehensive nursing intervention for patients with acute exacerbation of chronic bronchitis, which can effectively improve the patient's condition.%目的:对慢性支气管急性发作的护理方法予以探讨。方法随机选取我院2013年1月~2014年12月接收的慢性支气管炎急性发作期患者135例,针对患者的实际特点,积极为患者开展综合护理干预。结果患者治疗有效率达94.8%,护理满意度调查中显示,护理满意度为100%。结论积极为慢性支气管炎急性发作期患者开展综合护理干预,能够有效的改善患者的病情。

  3. Valuing the Economic Costs of Allergic Rhinitis, Acute Bronchitis, and Asthma from Exposure to Indoor Dampness and Mold in the US

    Directory of Open Access Journals (Sweden)

    David H. Mudarri

    2016-01-01

    Full Text Available Two foundational methods for estimating the total economic burden of disease are cost of illness (COI and willingness to pay (WTP. WTP measures the full cost to society, but WTP estimates are difficult to compute and rarely available. COI methods are more often used but less likely to reflect full costs. This paper attempts to estimate the full economic cost (2014$ of illnesses resulting from exposure to dampness and mold using COI methods and WTP where the data is available. A limited sensitivity analysis of alternative methods and assumptions demonstrates a wide potential range of estimates. In the final estimates, the total annual cost to society attributable to dampness and mold is estimated to be $3.7 (2.3–4.7 billion for allergic rhinitis, $1.9 (1.1–2.3 billion for acute bronchitis, $15.1 (9.4–20.6 billion for asthma morbidity, and $1.7 (0.4–4.5 billion for asthma mortality. The corresponding costs from all causes, not limited to dampness and mold, using the same approach would be $24.8 billion for allergic rhinitis, $13.5 billion for acute bronchitis, $94.5 billion for asthma morbidity, and $10.8 billion for asthma mortality.

  4. Bronquite infecciosa das galinhas: conhecimentos atuais, cepas e vacinas no Brasil Infectious bronchitis of chickens: current knowledge, strains and vaccines in Brazil

    Directory of Open Access Journals (Sweden)

    Juliana Figueiredo Pitangui Mendonça

    2009-11-01

    Full Text Available A bronquite infecciosa das galinhas (IB é uma doença viral aguda e altamente contagiosa que provoca grandes perdas econômicas à indústria avícola em todo o mundo. Considerando que surtos têm ocorrido no Brasil com emergência de novas variantes de IBV, desafiando as estratégias de vacinação atuais, este trabalho objetiva revisar os conhecimentos sobre IB e IBV, a sua distribuição, as cepas e as vacinas utilizadas no Brasil.Infectious bronchitis (IB is an acute, highly contagious disease of chickens, caused by infectious bronchitis virus (IBV, which results in great economic losses to the poultry industry worldwide, despite the routine use of vaccines. Several outbreaks do occur periodically in densely populated poultry regions in Brazil and there are constant emergence of new variants. The aim of this paper is to review the current knowledge about IBV and IB, the distribution, strains and vaccines in Brazil.

  5. Protection conferred by a recombinant Marek’s disease virus that expresses the spike protein from infectious bronchitis virus in specific pathogen-free chicken

    Directory of Open Access Journals (Sweden)

    Zhang Xiaorong

    2012-05-01

    Full Text Available Abstract Background In many countries, the predominant field isolates of infectious bronchitis virus (IBV have been classified as QX-like strains since 1996. However, no commercial vaccines that are specific for this type of IBV are currently available. Therefore, there is an urgent need to develop novel vaccines that prevent QX-like IBV infection. Results A recombinant Marek’s disease virus (MDV, rMDV-S1, that expresses the S1 subunit of the spike (S protein from the QX-like infectious bronchitis virus (IBV was constructed by inserting the IBV S1 gene into the genome of the CVI988/Rispens strain of MDV. Specific pathogen-free (SPF chickens that were vaccinated with rMDV-S1 were protected when challenged with the QX-like IBV. They were observed to have mild clinical signs of disease, a short virus-shedding period and low mortality. Additionally, the rMDV-S1 conferred full protection to chickens against virulent MDV, as did the CVI988/Rispens strain. Conclusions Our results demonstrate that rMDV-S1 is an effective and promising recombinant vaccine for the prevention of QX-like IBV infection.

  6. Valuing the Economic Costs of Allergic Rhinitis, Acute Bronchitis, and Asthma from Exposure to Indoor Dampness and Mold in the US

    Science.gov (United States)

    2016-01-01

    Two foundational methods for estimating the total economic burden of disease are cost of illness (COI) and willingness to pay (WTP). WTP measures the full cost to society, but WTP estimates are difficult to compute and rarely available. COI methods are more often used but less likely to reflect full costs. This paper attempts to estimate the full economic cost (2014$) of illnesses resulting from exposure to dampness and mold using COI methods and WTP where the data is available. A limited sensitivity analysis of alternative methods and assumptions demonstrates a wide potential range of estimates. In the final estimates, the total annual cost to society attributable to dampness and mold is estimated to be $3.7 (2.3–4.7) billion for allergic rhinitis, $1.9 (1.1–2.3) billion for acute bronchitis, $15.1 (9.4–20.6) billion for asthma morbidity, and $1.7 (0.4–4.5) billion for asthma mortality. The corresponding costs from all causes, not limited to dampness and mold, using the same approach would be $24.8 billion for allergic rhinitis, $13.5 billion for acute bronchitis, $94.5 billion for asthma morbidity, and $10.8 billion for asthma mortality. PMID:27313630

  7. The measuring of the resorptive clearance of inhaled 99m technetium pertechnetate in normal persons and in patients with chronically obstructive bronchitis and with lung fibrosis

    International Nuclear Information System (INIS)

    On 32 patients with lung fibrosis of various genesis, chronically obstructive bronchitis and carcinomas the resorptive clearance of the lung in comparison to 12 normal persons was carried out, specifically with a 99mTc-pertechnate aerosol in an atomiser (particle diameter of < 1 μm) doing inspiring vital capacity manuveurs. Patients with chronically obstructive bronchitis and lung fibrosis showed a clearance which slowed down in the middle, carcinoma patients showed a strongly slowed resorptive clearance in the diseased areas. A comparison with spirometric data and gas exchange parameters brought merely for MMEF a weakly significant correlation. A decisive influence of the condition of the bronchial mucous membrane on the result of the resorptive clearance was ascertained. Pollutants remain with decreased clearance longer in the lung and could possibly increase a predisposition to cancer. By the measuring of the resorptive clearance it can at least be determined which people were exposed for longer times to the damaging effects of such materials. (TRV)

  8. Recombinant infectious bronchitis virus (IBV) H120 vaccine strain expressing the hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) protects chickens against IBV and NDV challenge.

    Science.gov (United States)

    Yang, Xin; Zhou, Yingshun; Li, Jianan; Fu, Li; Ji, Gaosheng; Zeng, Fanya; Zhou, Long; Gao, Wenqian; Wang, Hongning

    2016-05-01

    Infectious bronchitis (IB) and Newcastle disease (ND) are common viral diseases of chickens, which are caused by infectious bronchitis virus (IBV) and Newcastle disease virus (NDV), respectively. Vaccination with live attenuated strains of IBV-H120 and NDV-LaSota are important for the control of IB and ND. However, conventional live attenuated vaccines are expensive and result in the inability to differentiate between infected and vaccinated chickens. Therefore, there is an urgent need to develop new efficacious vaccines. In this study, using a previously established reverse genetics system, we generated a recombinant IBV virus based on the IBV H120 vaccine strain expressing the haemagglutinin-neuraminidase (HN) protein of NDV. The recombinant virus, R-H120-HN/5a, exhibited growth dynamics, pathogenicity and viral titers that were similar to those of the parental IBV H120, but it had acquired hemagglutination activity from NDV. Vaccination of SPF chickens with the R-H120-HN/5a virus induced a humoral response at a level comparable to that of the LaSota/H120 commercial bivalent vaccine and provided significant protection against challenge with virulent IBV and NDV. In summary, the results of this study indicate that the IBV H120 strain could serve as an effective tool for designing vaccines against IB and other infectious diseases, and the generation of IBV R-H120-HN/5a provides a solid foundation for the development of an effective bivalent vaccine against IBV and NDV. PMID:26873815

  9. Expression, crystallization and preliminary X-ray diffraction analysis of the N-terminal domain of nsp2 from avian infectious bronchitis virus

    International Nuclear Information System (INIS)

    The N-terminal domain of nsp2 from avian infectious bronchitis virus has been purified and crystallized. The crystals diffracted to 2.5 Å resolution. Avian infectious bronchitis virus (IBV) is a prototype of the group III coronaviruses and encodes 15 nonstructural proteins which make up the transcription/replication machinery. The nsp2 protein from IBV has a unique and novel sequence and has no experimentally confirmed function in replication, whereas it has been proposed to be crucial for early viral infection and may inhibit the early host immune response. The gene that encodes a double-mutant IBV nsp2 N-terminal domain (residues 9–393 of the polyprotein, with mutations Q132L and L270F) was cloned and expressed in Escherichia coli and the protein was subjected to crystallization trials. The crystals diffracted to 2.5 Å resolution and belonged to space group P62 or P64, with unit-cell parameters a = b = 114.2, c = 61.0 Å, α = β = 90, γ = 120°. Each asymmetric unit contained one molecule

  10. Chyloptysis causing plastic bronchitis

    Directory of Open Access Journals (Sweden)

    Alice Stoddart

    2014-01-01

    Full Text Available Chyloptysis is a rare clinical problem that is associated with conditions affecting lymphatic channels in the thorax. Diagnosis is usually made when the patients present with expectoration of milky-white sputum or of thick tenacious mucus in the shape of smaller bronchi (bronchial cast. Typically the symptoms resolve after coughing up of the bronchial casts. Pleural, mediastinal, pulmonary or lymphatic abnormalities result in chyloptysis. Lymphangiography and detection of lipids (cholesterol or triglycerides in sputum help to establish the diagnosis. However, lymphangiography may not be positive in all patients. We report 2 patients with chyloptysis and bronchial casts with different etiologies. Abnormal lymphatics were demonstrated in one of our cases, but the second patients lymphangiogram was normal. In this patient we suspect that high venous filling pressures due to congestive heart failure had a causative effect in the setting of compromised lymphatic drainage in the thorax due to a prior history of radiation therapy to the chest for lymphoma.

  11. Experimental co-infection of SPF chickens with low pathogenicity avian influenza virus (LPAIV) subtypes H9N2, H5N2 and H7N9, and infectious bronchitis virus (IBV)

    Science.gov (United States)

    Avian influenza virus (AIV) and infectious bronchitis virus (IBV) are two of the most important respiratory viruses affecting poultry worldwide, but little is known about the effect of co-infection of these two viruses in poultry. Low pathogenicity (LP) AIV can produce from mild to moderate upper r...

  12. 阿奇霉素门诊治疗急性支气管炎疗效分析%The Efficacy of Azithromycin for Acute Bronchitis Outpatient

    Institute of Scientific and Technical Information of China (English)

    赵海伶

    2011-01-01

    目的:探讨阿奇霉素门诊治疗急性支气管炎的有效性.方法:选择142例门诊急性支气管炎患者,分为两组,青霉素组应用青霉素静脉640万单位/d静滴,阿奇霉素组应用阿奇霉素500mg加入0.9%生理盐水250mL静滴,Qd,1个疗程时,比较两组患者临床症状改善时间,确定患者临床痊愈时间和影像学痊愈时间,评价患者治疗效果.结果:阿奇霉素组咳嗽咳痰时间以及咽痛改善时间明显快于青霉素组,呼吸困难和发热改善时间差异无统计学意义,阿奇霉素组显效率明显优于青霉素治疗组,阿奇霉素组临床痊愈时间和影像学痊愈时间均明显优于青霉素组.结论:门诊急性支气管炎患者,应用阿奇霉素起效迅速,对咳嗽咳痰和咽痛改善明显,总临床疗效优于青霉素.%Objective: To investigate the azithromycin effectiveness of acute bronchitis outpatient.Method: 142 patients with acute bronchitis each were divided into two groups, penicillin group received intravenous penicillin 6.4 million units each day intravenously 500rug azithromycin were added into 250mL 0.9% saline infusion, Qd, 1 course of treatment, the Comparison of clinical symptoms improved time to determine the clinical recovery time and then evaluated patient outcomes. Result: The time of azithromycin and sore throat, cough and expectoration improve the time was faster than the penicillin group, dyspnea, and fever to improve the time difference was not statistically significant, the efficiency of azithromycin group was significantly superior to penicillin treatment group, clinical cure azithromycin group and imaging time recovery time were significantly better than the penicillin group. Conclusion: The patient with acute bronchitis,the application of azithromycin rapid onset of cough and expectoration and sore throat are significantly improved, the total clinical effective are more valider than penicillin.

  13. Impact of exacerbations on health care cost and resource utilization in chronic obstructive pulmonary disease patients with chronic bronchitis from a predominantly Medicare population

    Directory of Open Access Journals (Sweden)

    Pasquale MK

    2012-11-01

    Full Text Available Margaret K Pasquale,1 Shawn X Sun,2 Frank Song,1 Heather J Hartnett,1 Stephen A Stemkowski11Competitive Health Analytics, Louisville, KY, USA; 2Health Economics and Outcomes Research, Forest Research Institute, Jersey City, NJ, USABackground: Exacerbations of chronic obstructive pulmonary disease (COPD lead to significant increases in resource utilization and cost to the health care system. COPD patients with chronic bronchitis and a history of exacerbations pose an additional burden to the system. This study examined health care utilization and cost among these patients.Methods: For this retrospective analysis, data were extracted from a large national health plan with a predominantly Medicare population. This study involved patients who were aged 40–89 years, had been enrolled continuously for 24 months or more, had at least two separate insurance claims for COPD with chronic bronchitis (International Classification of Diseases, Ninth Revision, Clinical Modification code 491.xx, and had pharmacy claims for COPD maintenance medications between January 1, 2007, and March 31, 2009. Two years of data were examined for each patient; the index date was defined as the first occurrence of COPD. Baseline characteristics were obtained from the first year of data, with health outcomes tracked in the second year. Severe exacerbation was defined by COPD-related hospitalization or death; moderate exacerbation was defined by oral or parenteral corticosteroid use. Adjusted numbers of exacerbations and COPD-related costs per patient were estimated controlling for demographic and clinical characteristics.Results: The final study sample involved 8554 patients; mean age was 70.1 ± 8.6 years and 49.8% of the overall population had exacerbation, 13.9% had a severe exacerbation only, 29.1% had a moderate exacerbation only, and 6.8% had both a severe and moderate exacerbation. COPD-related mean annual costs were $4069 (all figures given in US dollars for the

  14. Aclidinium bromide inhalation powder for the long-term, maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease including chronic bronchitis and emphysema.

    Science.gov (United States)

    Matera, Maria Gabriella; Sanduzzi, Alessandro; Alfano, Roberto; Cazzola, Mario

    2016-06-01

    Aclidinium is a twice-daily long-acting muscarinic receptor antagonist (LAMA) with an interesting pharmacological profile. Recent evidence indicates that this LAMA, in addition to causing a significant improvement in lung function and other important supportive outcomes, such as health related quality of life, dyspnea and nighttime/early morning symptoms in patients suffering from COPD, is also able to significantly reduce the rate of exacerbations of any severity, is extremely effective in controlling the COPD symptoms, is able to reduce lung hyperinflation, and has an excellent cardiovascular safety profile. Consequently, aclidinium should be considered a first-line approach at least for the symptomatic treatment of COPD although there are still few head-to-head studies comparing this LAMA with other bronchodilators. In any case, aclidinium can be taken into account in the treatment of different COPD phenotypes (emphysema, chronic bronchitis, exacerbators and patients with overlap COPD asthma). PMID:26998725

  15. Advances in the diagnosis and treatment of children with plastic bronchitis%儿童塑型性支气管炎诊疗进展

    Institute of Scientific and Technical Information of China (English)

    张雪

    2013-01-01

    儿童塑型性支气管炎是一种较罕见的疾病,病因不明,起病隐匿,进展快,症状重,诊断和治疗难度大,病死率高.儿童塑型支气管炎被认为与某些疾病包括支气管哮喘、囊性纤维病、伴发急性胸部综合征的镰状细胞病、先天性心脏病以及各种呼吸道细菌性和病毒性感染有一定关系.关于儿童塑型性支气管炎的诊断和治疗目前仍较困难,临床医生应该警惕该病,做到早期诊断、早期治疗.%Children with plastic bronchitis,characterized by unknown origin,insidious onset,rapid progress,severe symptom and high mortality,is a relatively rare disease.Also,it is difficult to diagnose and treat with plastic bronchitis characterized by marked airway obstruction,via the formation of large gelatinous or rigid airway cast.It is associated with certain diseases including bronchial asthma,cystic fibrosis,accompanied with acute chest syndrome with sickle cell disease,congenital heart disease and bacterial and viral respiratory infection.Clinicians should be aware of this disease,and early bronchoscopy should be intervened.

  16. 盐酸美西律治疗慢性支气管炎临床分析%Clinical Analysis of Mexiletine Hydrochloride Treatment for Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    赵丹

    2013-01-01

    目的:观察盐酸美西律雾化吸入治疗慢性支气管炎急性发作时的临床疗效。方法选取我院收治的56例慢性支气管炎急性发作患者,随机分两组,对照组给予常规治疗,实验组在常规治疗的基础上加盐酸美西律注射液15mg、生理盐水5ml进行雾化吸入治疗。结果对照组总有效率75%,实验组总有效率93%。结论加用盐酸美西律雾化吸入治疗有利于缩短病程,值得推广应用。%Objective To observe the clinical ef icacy of mexiletine hydrochloride inhalation in treatment of acute exacerbations of chronic bronchitis. Methods:in our hospital treated 56 cases of acute exacerbations of chronic bronchitis, were randomly divided into two groups, the control group was given conventional treatment, the experimental group on the basis of conventional therapy plus mexiletine hydrochloride injection 15mg, saline inhalation of 5ml treatment. Results:the total ef ective rate of the control group 75%, the experimental group, the total ef iciency of 93%. Conclusion: combined with mexiletine hydrochloride inhalation therapy can shorten the course of disease, it is worthy of popularization and application.

  17. Construction and immunogenicity studies of recombinant fowl poxvirus containing the S1 gene of Massachusetts 41 strain of infectious bronchitis virus.

    Science.gov (United States)

    Wang, Xiuqing; Schnitzlein, William M; Tripathy, Deoki N; Girshick, Theodore; Khan, Mazhar I

    2002-01-01

    The spike 1 (S1) surface glycoprotein of infectious bronchitis virus (IBV) is the major inducer of the generation of virus neutralizing antibodies, and the administration of purified S1 has been shown to elicit a protective immune response against virulent virus challenge. On the basis of these observations, recombinant fowl poxvirus (rFPV) containing a cDNA copy of the S1 gene of IBV Mass 41 (rFPV-S1) was constructed and its immunogenicity and vaccine potential were evaluated. Initially, rFPV-S1 was shown to express the S1 in vito by indirect immunofluorescence staining and western blot analyses. Later, in vivo expression was demonstrated by the detection of IBV-specific serum immunoglobulin G and neutralization antibodies in the sera of chickens immunized with rFPV-S1. That the recombinant virus elicited anti-IBV protective immunity was indicated by the manifested, relatively mild clinical signs of disease, decreased titers of recovered challenge virus, and less severe histologic changes of the tracheas in virulent IBV Mass 41-challenged chickens previously receiving rFPV-S1 as compared with parental fowl poxvirus (FPV)-vaccinated control birds. In contrast, chickens immunized with either recombinant or parental FPV were resistant to a subsequent virulent FPV challenge. As to a preferred method of immunization, wing web administration appeared to be superior to the subcutaneous route because a greater percentage of birds vaccinated by the former protocol exhibited an anti-IBV humoral immune response. Thus, rFPV-S1 has potential as a poultry vaccine against both fowl pox and infectious bronchitis. PMID:12495043

  18. High-dose oral N-acetylcysteine fails to improve respiratory health status in patients with chronic obstructive pulmonary disease and chronic bronchitis: a randomized, placebo-controlled trial

    Directory of Open Access Journals (Sweden)

    Johnson K

    2016-04-01

    Full Text Available Kara Johnson,1,2 Charlene E McEvoy,3 Sakina Naqvi,1,4 Chris Wendt,1 Ronald A Reilkoff,4,5 Ken M Kunisaki,1 Erin E Wetherbee,1 David Nelson,6 Rabindra Tirouvanziam,7 Dennis E Niewoehner1 1Pulmonary Section, Minneapolis VA Health Care System, Minneapolis, MN, 2Sanford Health, Fargo, ND, 3Pulmonary Section, HealthPartners Research Foundation, St Paul, 4HealthEast Maplewood Clinic, Maplewood, 5Pulmonary Section, University of Minnesota Medical Center, 6Center for Chronic Disease Outcomes Research, Minneapolis VA Health Care System, Minneapolis, MN, 7Center for Cystic Fibrosis and Airways Disease Research, Emory University School of Medicine, Atlanta, GA, USA Background: Clinical outcomes are worse in patients with COPD and chronic bronchitis. N-acetylcysteine (NAC is commonly prescribed for such patients but with uncertain clinical benefits. We postulated that oral NAC, at much larger doses than those ordinarily prescribed, would improve clinical outcomes in a subset of patients with COPD and chronic bronchitis. Objective: The aim of this study was to determine whether very high-dose NAC would improve respiratory health status in patients with COPD and chronic bronchitis. Methods: Patients with COPD and chronic bronchitis were enrolled in a randomized, controlled, double-blinded trial. Patients received oral NAC (1,800 mg or matching placebo twice daily for 8 weeks in addition to their usual respiratory medications. The primary outcome, respiratory health status, was assessed by changes in the St George’s Respiratory Questionnaire. The effects of NAC on lung function and circulating markers of oxidative stress and inflammation were also evaluated. Results: We terminated the study prematurely because new external information suggested the possibility of a safety issue. Of the planned 130 patients, 51 were randomized and 45 (22 in the placebo arm and 23 in the NAC arm completed the study. There was no statistically significant difference between

  19. Clinical Observation on Qingfei Huatan Granula in Treating 129 Acute Tracheal Bronchitis or Chronic Bronchitis Patients%“清肺化痰颗粒”治疗急性气管—支气管炎及慢性支气管炎急性发作129例临床观察

    Institute of Scientific and Technical Information of China (English)

    张前进; 吕凤霞; 王华; 王丽勤

    2011-01-01

    [Objective] The aim of this study is to investigate the effects of Qingfei Huatan Granula on the 129 patients suffering from acute tracheal bronchitis or chronic bronchitis. [Methods] 129 patients were divided randomly into treatment group and control group. Qingfei Huatan Granula was given to the patients of treatment group. LingYang QingFei Pills was given to the patients of control group. Therapeutic evaluation was based on recovery of a cough and sputum. [Results] The curative effect of Qingfei Huatan Granula on the acute stage of chronic bronchitis showed that the clinical total effective rate was 84.4%,the rate of cough 87.5% and the rate of sputum 89.1%. The curative effect of LingYang QingFei Pills on the acute stage of chronic bronchitis showed that the clinical total effective rate was 81.6%,of cough 81.6% and of sputum 78.9%. The curative effect on sputum in the trial group was more significant. The curative effect of Qingfei Huatan Granula on acute tracheobronchitis showed that the clinical total effective rate was 89.2% , of cough and sputum 89.2%. The curative effect of LingYang QingFei Pills on acute tracheobronchitis showed that the clinical total effective rate was 84.4% , the rate of cough 84.4% and the rate of sputum 81.3%. The curative effect on comprehensive therapeutic efficacy and sputum in the trial group was more significant. [Conclusions] The curative effect of Qingfei Huatan Granula was better than that of LingYang QingFei Pills in comprehensive therapeutic efficacy and relief of cough and sputum of two diseases. The curative effect on comprehensive therapeutic efficacy and sputum of acute tracheobronchitis and on sputum of the acute stage of chronic bronchitis in the trial group was significant.%[目的]观察“清肺化痰颗粒”对急性气管—支气管炎及慢性支气管炎急性发作的疗效.[方法]将199例观察对象随机分为两组,治疗组129例给予“清肺化痰颗粒”,3次/d,每次1袋,1周为1个疗程;对

  20. 小儿肺咳颗粒对急性小儿支气管炎治疗的临床观察%Clinical Effects of Pediatric Lung Cough Particles on Acute Bronchitis in Children

    Institute of Scientific and Technical Information of China (English)

    王晴晴; 过桥

    2014-01-01

    Objective:To study the clinical effects of Pediatric Lung Cough Particles on acute bronchitis in children.Method:280 patients with acute bronchitis from July 2012 to July 2014 in our hospital were studied.The patients were randomly divided into two groups,the observation group,200 cases (Pediatric Lung Cough Particles),and the control group,80 cases (cefotaxime by intravenous dripping).The clinical symptoms,clinical signs and symptoms score to quantify adverse reactions were observed. A course of treatment to determine efficacy.Result:The clinical signs and symptoms score of the two groups were all significantly reducing(P0.05)。结论:小儿肺咳颗粒治疗急性小儿支气管炎有显著效果,值得在临床上推广。

  1. SEROLOGIC DYNAMIC OF INFECTIO US BRONCHITIS VIRUS IN A BROILER FLOCK IN CUNDINAMARCA DINÁMICA SEROLÓGICA DEL VIRUS DE BRONQUITIS INFECCIOSA EN UNA GRANJA DE POLLO DE ENGORDE DEL DEPARTAMENTO DE CUNDINAMARCA

    OpenAIRE

    Vera Alfonso Victor Julio; Jaime Correa Jairo; Usma Jorge Alberto; Alvarez Espejo Diana Claudia

    2009-01-01

    The infectious bronchitis virus (IBV) causes a highly contagious disease, spread worldwide, leading to serious economic losses. Sometimes the disease is associated with other entities such as infectious bursal disease virus, Newcastle disease virus, Mycoplasma gallisepticum and Escherichia coli. The highly genetic variability of the virus has generated a large number of viral strains with different clinical presentations. The objective was to assess the dynamics of the virus antibodies in bir...

  2. Treating 50 cases of acute bronchitis in children with Zhisou powder plus Sanzi Yangqin decoction%止嗽散合三子养亲汤治疗小儿急性支气管炎50例

    Institute of Scientific and Technical Information of China (English)

    王云蝶; 孙真香

    2014-01-01

    Objective: To observe the efficacy on treating acute bronchitis in children with Zhisou powder plus Sanzi Yangqin decoction. Methods: 50 cases of acute bronchitis in children treated with Zhisou powder plus Sanzi Yangqin decoction, statistical effect after 7 days. Results:39 cases were cured, 7 cases improved, 4 cases ineffective, the total efficiency was 92%. Conclusion:Zhisou powder plus Sanzi Yangqin decoction is effective on treating acute bronchitis in children, worthy of a wide clinical application.%目的:观察止嗽散合三子养亲汤治疗小儿急性支气管炎的疗效。方法:将50例急性支气管炎患儿予止嗽散合三子养亲汤7d后统计疗效。结果:治愈39例,好转7例,未愈4例,总有效率92%。结论:采用止嗽散合三子养亲汤治疗小儿急性支气管炎,疗效显著,值得临床推广应用。

  3. 溴己新治疗慢性支气管炎的疗效评价%Curative effect evaluation of bromhexine for the treatment of chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    邓梓辛; 张美祥; 谭璐; 汪曲; 王树平

    2015-01-01

    Objective To assess the effect and safety of bromhexine for chronic bronchitis .Methods We retrieve the database inclu‐ding PubMed ,the Cochrane library ,China National Knowledge Internet (CNKI) ,Weip Database (VIP) and Wanfang Data . Eight randomized controlled trials (RCT ) comparing bromhexine with ambroxol ,Erchentang ,Kechuanning oral liquid ,S‐carboxy‐methylcysteine and placebo were included in this research .The course of treatment was more than 5 days .The Jadad quality tools was used for the quality evaluation of each study .Results There were 4 RCTs which compared bromhexine with ambroxol ,with significant difference in clinical overall efficacy [RR=0 .83 ,95% CI(0 .76 ,0 .91) ,P<0 .000 1] .The rest groups required descrip‐tive analysis for study quantity .Conclusion Chronic bronchitis can be treated effectively by bromhexine .However ,compared with ambroxol ,the result of quality grade and Meta‐analysis reveals lower curative effect .%目的:评价溴己新治疗慢性支气管炎的疗效及安全性。方法通过检索PubMed、Cochrane library、中国期刊全文数据库(China National Knowledge Internet ,CNKI)、维普数据库(Weip Database ,VIP)和万方数字化期刊全文数据库;纳入随机对照试验(Randomized Controlled Trial ,RCT)8篇,包括溴己新对比氨溴索、二陈汤、咳喘宁口服液、S‐羧甲半胱氨酸和安慰剂组;利用Jadad质量评分工具进行方法质量评价。结果溴己新组对比氨溴索组共4个RC T ,临床总有效率比较:R R=0.83,95% C I (0.76,0.91),P<0.0001,差异有统计学意义。其余组由于文献数量少限制而进行描述性分析。结论溴己新可以有效地治疗慢性支气管炎,但是质量评分以及Meta分析显示其疗效低于氨溴索。

  4. Molecular detection of infectious bronchitis virus and it is relation with avian influenza virus (H9 and Mycoplasma gallisepticum from different geographical regions in Iraq

    Directory of Open Access Journals (Sweden)

    A.H. Al-Dabhawe

    2013-12-01

    Full Text Available Infectious bronchitis virus (IBV, Avian influenza virus (AIV and Mycoplasma gallisepticum (MG have been recognized as the most important pathogens in poultry cause acute respiratory infection and serous economic problems in Iraq and many other countries all over the world. This study was conducted to investigate the distribution of these diseases in commercial chicken flocks in different geographical region in middle part of Iraq by using qPCR. Tracheal swabs and tissue specimens from trachea, lung and kidney were taken from 38 different cases from commercial broiler chicken flocks in (Najaf, Hilla, Muthana and Theqaar governorates in the period from November 2010 to June 2011, all these flocks were showed respiratory symptoms and mortality about 20-90%. The results showed that 92.1% of samples collected from these flocks were infected with IBV, 20% of samples were infected with IB alone and 45.71% of samples with IB combined with both GM and AIV subtype H9 and 25.71% of samples were positive to both IBV and AIV(H9. No samples were positive to AIV (H9 or MG alone. Because of importance of respiratory diseases as a most common conditions noted in commercial flocks in Iraq and no previous study detecting this pathogens by molecular techniques, this study come to detect and confirm the diagnosis of this pathogens by qPCR as new technique used in this field in Iraq.

  5. Inhaler use in adolescents and adults with self-reported physician-diagnosed asthma, bronchitis, or emphysema in the city of Pelotas, Brazil

    Directory of Open Access Journals (Sweden)

    Paula Duarte de Oliveira

    2013-06-01

    Full Text Available OBJECTIVE: To evaluate the characteristics of users of inhalers and the prevalence of inhaler use among adolescents and adults with self-reported physician-diagnosed asthma, bronchitis, or emphysema. METHODS: A population-based study conducted in the city of Pelotas, Brazil, involving 3,670 subjects ≥ 10 years of age, evaluated with a questionnaire. RESULTS: Approximately 10% of the sample reported at least one of the respiratory diseases studied. Among those individuals, 59% reported respiratory symptoms in the last year, and, of those, only half reported using inhalers. The use of inhalers differed significantly by socioeconomic status (39% and 61% for the lowest and the highest, respectively, p = 0.01. The frequency of inhaler use did not differ by gender or age. Among the individuals reporting emphysema and inhaler use, the use of the bronchodilator-corticosteroid combination was more common than was that of a bronchodilator alone. Only among the individuals reporting physician-diagnosed asthma and current symptoms was the proportion of inhaler users higher than 50%. CONCLUSIONS: In our sample, inhalers were underutilized, and the type of medication used by the individuals who reported emphysema does not seem to be in accordance with the consensus recommendations.

  6. Eggshell apex abnormalities in a free-range hen farm with mycoplasma synoviae and infectious bronchitis virus in Rio de Janeiro state, Brazil

    Directory of Open Access Journals (Sweden)

    FC dos Santos

    2014-06-01

    Full Text Available A farm with 3,000 free-range hens between 24 and 65 weeks of age was investigated. These hens were separated in small flocks of 400 to 700 birds, presenting 10 to 23% egg production reduction. Twenty serum samples were collected during the period of drop in egg production and three weeks later for the investigation of Mycoplasma synoviae (MS, M. gallisepticum (MG and Infectious Bronchitis Virus (IBV antibodies using ELISA. At the time of the second collection, egg production had resumed to normal levels; however, with 10.23% of the eggs showed eggshell abnormalities limited to the apex. Eggshell strength was significantly different between normal and those with eggshell apex abnormalities, but not other egg-quality parameters. ELISA tests showed that MS and IBV titers increased during the evaluated period. MS infection was confirmed by culture and by PCR of tracheal swabs. All samples were negative for MG by ELISA and PCR. Further studies with larger samples to ensure the occurrence of this disease in industrial layer flocks in Brazil are under way.

  7. Fine level epitope mapping and conservation analysis of two novel linear B-cell epitopes of the avian infectious bronchitis coronavirus nucleocapsid protein.

    Science.gov (United States)

    Han, Zongxi; Zhao, Fei; Shao, Yuhao; Liu, Xiaoli; Kong, Xiangang; Song, Yang; Liu, Shengwang

    2013-01-01

    The nucleocapsid (N) protein of the infectious bronchitis virus (IBV) may play an essential role in the replication and translation of viral RNA. The N protein can also induce high titers of cross-reactive antibodies and cell-mediated immunity, which protects chickens from acute infection. In this study, we generated two monoclonal antibodies (mAbs), designated as 6D10 and 4F10, which were directed against the N protein of IBV using the whole viral particles as immunogens. Both of the mAbs do not cross react with Newcastle disease virus (NDV), infectious laryngotracheitis virus (ILTV) and subtype H9 avian influenza virus (AIV). After screening a phage display peptide library and peptide scanning, we identified two linear B-cell epitopes that were recognized by the mAbs 6D10 and 4F10, which corresponded to the amino acid sequences (242)FGPRTK(247) and (195)DLIARAAKI(203), respectively, in the IBV N protein. Alignments of amino acid sequences from a large number of IBV isolates indicated that the two epitopes, especially (242)FGPRTK(247), were well conserved among IBV strains. This conclusion was further confirmed by the relationships of 18 heterologous sequences to the 2 mAbs. The novel mAbs and the epitopes identified will be useful for developing diagnostic assays for IBV infections. PMID:23123213

  8. A recombinant turkey herpesvirus expressing chicken interleukin-2 increases the protection provided by in ovo vaccination with infectious bursal disease and infectious bronchitis virus.

    Science.gov (United States)

    Tarpey, I; van Loon, A A; de Haas, N; Davis, P J; Orbell, S; Cavanagh, D; Britton, P; Casais, R; Sondermeijer, P; Sundick, R

    2007-12-12

    In ovo vaccination remains an attractive option for the mass application of vaccines to poultry, ensuring a uniform application of vaccine in a cost-effective manner. However, the number of vaccines that can be delivered safely by this method is limited. Several infectious bursal disease virus (IBDV) vaccines can be given in ovo though most are delivered post-hatch and there are no currently licensed embryo-safe infectious bronchitis virus (IBV) vaccines. Reduction in the dose of vaccines given in ovo is one possibility to ensure embryo safety though efficacy can be reduced when low doses are used. We have investigated the use of embryo-safe IBDV and IBV vaccines and the effects of co-delivery of a turkey herpesvirus recombinant expressing bioactive chicken IL-2 (IL-2/HVT). Co-delivery of the IL-2/HVT with low doses of the IBDV or IBV vaccines significantly increased the antibody response against these viruses. In addition the protection against challenge with virulent IBDV or IBV was increased significantly. This suggests that the co-delivery of IL-2/HVT with low doses of other vaccines in ovo may be one method to increase the number of vaccines that can be given safely and efficaciously via in ovo vaccination. PMID:17996994

  9. Tissue distribution of avian infectious bronchitis virus following in ovo inoculation of chicken embryos examined by in situ hybridization with antisense digoxigenin-labeled universal riboprobe.

    Science.gov (United States)

    Lee, Chang-Won; Brown, Corrie; Jackwood, Mark W

    2002-09-01

    Chicken embryos were inoculated with 8 different strains of infectious bronchitis virus (IBV) representing 7 different serotypes at 17 days of embryonation. At 2 and 5 days postinfection (dpi), tissues were collected for in situ hybridization using an antisense digoxigenin-labeled riboprobe corresponding to the sequence of the mRNA coding for the membrane protein. Extensive antigen staining in the cytoplasm of epithelial cells in the trachea, lung, bursa, and intestine was detected at 2 dpi with all 8 strains of IBV. At 5 dpi, little or no positive staining was observed in these tissues. However, tubular cells of the kidney showed multifocal positive staining with the Wolgemuth strain-, Gray strain-, JMK strain-, and Mass41 strain-infected chickens. No viral RNA was detected in the spleen at any time point. The results demonstrated strict epitheliotropic nature and wide tissue tropism of strains of IBV in the chicken embryo and the universality of our riboprobe. In situ hybridization with this probe will be useful for understanding the tissue tropism and the pathogenesis of IBV in vivo. PMID:12296388

  10. Ameliorative effect of a microbial feed additive on infectious bronchitis virus antibody titer and stress index in broiler chicks fed deoxynivalenol.

    Science.gov (United States)

    Ghareeb, K; Awad, W A; Böhm, J

    2012-04-01

    Although acute mycotoxicoses are rare in poultry production, chronic exposure to low levels of mycotoxins is responsible for reduced productivity and increased susceptibility to infectious diseases. Deoxynivalenol (DON) is known to modulate immune function, but only a few studies have investigated the effect of DON on the vaccinal immune response. In addition, the effects of Mycofix select (Biomin GmbH, Herzogenburg, Austria) supplementation to DON-contaminated broiler diets have not yet been demonstrated. Therefore, an experiment with 1-d-old male broilers (Ross 308) was carried out to examine the effects of feeding DON-contaminated low-protein grower diets on performance, serum biochemical parameters, lymphoid organ weight, and antibody titers to infectious bronchitis vaccination in serum and to evaluate the effects of Mycofix select dietary supplementation in either the presence or absence of DON in broilers. In total, thirty-two 1-d-old broiler chicks were randomly assigned to 1 of the 4 dietary treatments for 5 wk. The dietary treatments were 1) control; 2) artificially contaminated diets with 10 mg of DON/kg of diet; 3) DON-contaminated diets supplemented with Mycofix select; and 4) control diet supplemented with Mycofix select. Feeding of contaminated diets decreased (P = 0.000) the feed intake, BW (P = 0.001), BW gain (P = 0.044), and feed efficiency during the grower phase. Deoxynivalenol affected the blood biochemistry, whereas plasma total protein and uric acid concentrations in birds fed contaminated grains were decreased compared with those of the controls. Moreover, in birds fed contaminated feeds, there was a tendency to reduce triglycerides in the plasma (P = 0.090), suggesting that DON in the diets affected protein and lipid metabolism in broiler chickens. The feeding of contaminated diets altered the immune response in broilers by reducing the total lymphocyte count. Similarly, the antibody response against infectious bronchitis vaccination

  11. 鸡传染性支气管炎病毒的分离与鉴定%solation and Identification of Avian Infectious Bronchitis Virus

    Institute of Scientific and Technical Information of China (English)

    王正东; 余弟和; 张建军; 魏波

    2012-01-01

    [Objective]The aim of the study was to isolate an avian infectious bronchitis virus(IBV) isolate from the diseased chickens and identity its characteristics. [Method] An 1BV isolate was isolated from the diseased chickens in a chicken farm in Anhui Province and passaged blindly in chicken embryos to observe its pathogenicity. Then animal regression test was used to replicate bronchial congestion in SPF chickens. The SI gene fragment was amplified and its sequence was aligned with the IBV vaccine strains. [ Result ] The results of HA assay showed that the allantoic fluid of the IBV strain had no agglutination activity toward chicken red blood cells. This result suggested that no Newcastle disease virus and avian influenza virus were found in the allantoic fluid. However,the allanloic fluid treated with 10 g/L trypsin solution could agglutinate chicken red blood cells, which is in line with the biological characteristics of IBV. After the SPF chickens were inoculated with the sixth passage of the IBV I-solate, the clinical symptoms like bronchial congestion that were similar with those in clinic were observed. The results initially confirmed the isolation of an IBV isolate,which was named IBV XZ strain. [Conclusion]This study provides a theoretical basis for the prevention and treatment of avian infectious bronchitis.%[目的]从发病鸡群中分离出鸡传染性支气管炎病毒,并对其进行鉴定.[方法]从安徽某鸡场发病鸡群中分离出鸡传染性支气管是病毒,采用鸡胚盲传,观察病毒对鸡胚的致病作用.通过动物回归试验,在SPF鸡上复制出支气管堵塞的症状,扩增分离毒株的S1基因片段,并与IBV疫苗毒株进行比较.[结果]对分离到的毒株进行HA检测,结果表明收获的尿囊液对鸡红细胞无凝集活性,说明分离到的病毒中无NDV、AIV等,但经1%胰酶处理则可凝集鸡红细胞,符合传染性支气管炎病毒的生物学特征.该毒株的第6代SPF鸡胚尿囊液通过滴

  12. [Sequencing and Serologic Identification of S1 Genes of Infectious Bronchitis Viruses Isolated during 2012-2013 in Guangxi Province, China].

    Science.gov (United States)

    Zhang, Lihua; Wu, Cuilan; Zhang, Zhipeng; He, Yining; Li, Heming; Qin, Lili; Wei, Tianchao; Mo, Meilan; Wei, Ping

    2016-01-01

    We wished to ascertain the prevalence as well as the genetic and antigenic variation of infectious bronchitis viruses (IBVs) circulating in the Guangxi Province of China in recent years. The S1 gene of 15 IBV field isolates during 2012-2013 underwent analyses in terms of the similarity of amino-acid sequences, creation of phylogenetic trees, recombination, and serologic identification. Similarities in amino-acid sequences among the 15 isolates of the S1 gene were 54.3%-99.6%, and 43.3%-99.3% among 15 isolates and reference strains. Compared with the vaccine strain H120, except for GX-YL130025, the other 14 isolates showed a lower similarity of amino-acid sequences of the S1 gene (65.1-81.4%). Phylogenetic analyses of the S1 gene suggested that 15 IBV isolates were classified into eight genotypes, with the predominant genotype being new-type II. Recombination analyses demonstrated that the S1 gene of the GX-NN130048 isolate originated from recombination events between vaccine strain 4/91 and a LX4-like isolate. Serotyping results suggested that seven serotypes prevailed during 2012-2013 in Guangxi Province, and that only one isolate was consistent with the vaccine strain H120 in serotype (which has been used widely in recent years). The serotype of recombinant isolate GX-NN130048 was different from those of its parent strains. These results suggested that not only the genotype, but also the serotype of IBV field isolates in Guangxi Province had distinct variations, and that increasing numbers of genotypes and serotypes are in circulation. We showed that recombination events can lead to the emergence of new serotypes. Our study provides new evidence for understanding of the molecular mechanisms of IBV variations, and the development of new vaccines against IBVs. PMID:27295885

  13. Gemifloxacin for the treatment of community-acquired pneumonia and acute exacerbation of chronic bronchitis: a meta-analysis of randomized controlled trials

    Institute of Scientific and Technical Information of China (English)

    ZHANG Lei; WANG Rui; Falagas E. Matthew; CHEN Liang-an; LIU You-ning

    2012-01-01

    Background Gemifloxacin is a fluoroquinolone antibiotic with broad spectrum of antibacterial activity.The aim of the study was to evaluate the comparative effectiveness and safety of gemifloxacin for the treatment of patients with community-acquired pneumonia (CAP) or acute exacerbation of chronic bronchitis (AECB).Methods We performed a meta-analysis of randomized controlled trials (RCTs) comparing gemifloxacin with other approved antibiotics.The PubMed,EMBASE,Chinese Biomedical Literature Database and the Cochrane Central Register of Controlled Trials were searched,with no language restrictions.Results Ten RCTs,comparing gemifloxacin with other quinolones (in 5 RCTs) and β-lactams and/or macrolides (in 5 RCTs),involving 3940 patients,were included in this meta-analysis.Overall,the treatment success was higher for gemifloxacin when compared with other antibiotics (odds ratio 1.39,95% confidence interval 1.15-1.68 in intention-to-treat patients,and 1.33,1.02-1.73 in clinically evaluable patients).There was no significant difference between the compared antibiotics regarding microbiological success (1.19,0.84-1.68) or all-cause mortality (0.82,0.41-1.63).The total drug related adverse events were similar for gemifloxacin when compared with other quinolones (0.89,0.56-1.41),while lower when compared with β-lactams and/or macrolides (0.71,0.57-0.89).In subgroup analyses,administration of gemifloxacin was associated with fewer cases of diarrhoea and more rashes compared with other antibiotics (0.66,0.48-0.91,and 2.36,1.18-4.74,respectively).Conclusions The available evidence suggests that gemifloxacin 320 mg oral daily is equivalent or superior to other approved antibiotics in effectiveness and safety for CAP and AECB.The development of rash represents potential limitation of gemifloxacin.

  14. Genetic Diversity of Spike, 3a, 3b and E Genes of Infectious Bronchitis Viruses and Emergence of New Recombinants in Korea

    Directory of Open Access Journals (Sweden)

    Chang-Seon Song

    2013-01-01

    Full Text Available The nucleotide sequences of a region including S1, S2, 3a, 3b and E genes of twenty-seven infectious bronchitis virus (IBV isolates in Korea between 1990–2011 were determined and phylogenetic and computational recombination analyses were conducted. The sizes of coding regions of some genes varied among IBV isolates due to deletion or insertion of nucleotides; the nucleotide similarities of S1, S2, 3a, 3b and E genes among the 27 isolates were 75.9%–100.0%, 85%–100.0%, 64.0%–100.0%, 60.4%–100.0% and 83.1%–100.0%, respectively. According to phylogenetic analysis of S1 gene, the 27 isolates were divided into five genotypes, Mass, Korean-I (K-I, QX-like, KM91-like and New cluster 1. The phylogenetic trees based on the S2, 3a, 3b, E genes and S1-S2-3a-3b-E (S1-E region nucleotide sequences did not closely follow the clustering based on the S1 sequence. The New cluster 1 prevalent during 2009 and 2010 was not found in 2011 but QX-like viruses became prevalent in 2011. The recombination analysis revealed two new S gene recombinants, 11036 and 11052 which might have been derived from recombinations between the New cluster 1 and QX-like viruses and between the K-I and H120 (vaccine viruses, respectively. In conclusion, multiple IBV genotypes have co-circulated; QX-like viruses have recurred and new recombinants have emerged in Korea. This has enriched molecular epidemiology information of IBV and is useful for the control of IB in Korea.

  15. Analysis the Clinical Value of Ambroxol Hydrochloride in Acute Exacerbation of Chronic Bronchitis%盐酸氨溴索在慢性支气管炎急性加重期的临床价值分析

    Institute of Scientific and Technical Information of China (English)

    张美艳

    2015-01-01

    Objective To investigate the application value of ambroxol hydrochloride in acute exacerbation of chronic bronchitis.Methods84 cases of chronic bronchitis in acute exacerbation stage were divided into study group (conventional therapy plus ambroxol hydrochloride) and control group (conventional therapy),according to with the hospitalization sequence.Results The total effective rate of the study group was significantly higher than that of the control group, the two group had significant difference (P<0.05); The incidence of adverse reaction in the study group was significantly lower than that in the control group (P<0.05).Conclusion Ambroxol in chronic bronchitis acute exacerbation has a high application value.%目的:探讨盐酸氨溴索在慢性支气管炎急性加重期的应用价值。方法将84例慢性支气管炎急性加重期患者按照住院先后顺序分为研究组(常规治疗+盐酸氨溴索)与对照组(常规治疗)。结果研究组患者治疗总有效率明显高于对照组,二者有显著性差异(P<0.05);研究组不良反应发生率明显低于对照组(P<0.05)。结论盐酸氨溴索在慢性支气管炎急性加重期有着较高的应用价值。

  16. The Yanhuning injection in the treatment of acute bronchitis effect observed%炎琥宁注射液治疗急性支气管炎的效果观察

    Institute of Scientific and Technical Information of China (English)

    李瑛

    2012-01-01

      Objective Used in acute bronchitis Yanhuning injection effect for study. Methods Random selection in our hospital from June 2010 to June 2012 79 patients with acute bronchitis, divided into A and B group, A group of 45 patients for the treatment group, B group 34 patients of the control group were given Yanhuning injectionfluids and amoxicilin healing.Results A group of patients after treatment, fever, and other symptoms of wheezing and wheezing disappeared improve less than group B patients, treatment efficiency than in group B, the incidence of adverse reactions was significantly lower than that in group B patients.Conclusion Yanhuning injection used in acute bronchitis, a faster recovery of the patient's condition, there are more efficient.%  目的对炎琥宁注射液应用于急性支气管炎的效果加以研究分析。方法随机选择我院2010年6月-2012年6月急性支气管炎患者79名,分成A、B组,A组45名患者为治疗组,B组34名患者为对照组,分别给予炎琥宁注射液和阿莫西林医治。结果经治疗,A组患者发热、喘憋以及喘鸣音消失等病症改善时间均少于B组患者,治疗有效率高于B组,不良反应发生率明显低于B组患者。结论炎琥宁注射液应用于急性支气管炎,患者病症恢复较快,有效率较高。

  17. The Clinical Observation of Hormone in Treatment of Acute Phase of Chronic Bronchitis%激素治疗慢性支气管炎急性期临床观察

    Institute of Scientific and Technical Information of China (English)

    蔡朝敏; 汪传臻

    2013-01-01

      目的:观察激素短疗程治疗慢性支气管炎急性期临床疗效。方法:将93例慢性支气管炎急性发作期患者随机分为治疗组48例,对照组45例,对照组予常规抗感染、解痉平喘、吸氧等对症及支持治疗,治疗组在对照组治疗基础上短期加用激素治疗,观察临床疗效。结果:治疗组临床疗效明显高于对照组。结论:激素短程治疗慢性支气管炎急性期疗效显著,可作为首选治疗。%Objective:To observe the clinical effect of short course of glucocorticoid in treatment of acute phase of chronic bronchitis.Methods:93 cases of patients with acute phase of chronic bronchitis were randomly divided into a treatment group of 48 cases,45 cases in the control group,the control group received routine anti-infection,spasmolysis,oxygen and other symptomatic and supportive treatment,the treatment group on the basis of the control group treated with short-term hormone therapy,the clinical effect was observed.Results:The clinical effect of treatment group was significantly higher than the control group. Conclusion:The effect of short-term hormone in treatment of chronic bronchitis in acute phase is good,it can be used as the preferred treatment.

  18. 加减桑菊饮治疗支气管炎24例疗效观察%Clinical observation on treating 24 cases of bronchitis by the Sangju decoction

    Institute of Scientific and Technical Information of China (English)

    佘佑林

    2013-01-01

      目的:探讨中药组方桑菊饮的加减治疗支气管炎的临床疗效,以期为临床用药提供数据支持。方法:将我院于2011年6月~2012年6月间收治的48例支气管炎患者随机分为两组,每组24例患者,实验组根据中医辨证论治的原则给予加减桑菊饮治疗;对照组则采用急支糖浆进行治疗,治疗7d后对比两组疗效。结果:经治疗后,实验组患者总有效率为83.3%;对照组为66.7%,实验组疗效显著优于对照组(x2=4.763,P<0.05)。结论:根据中医辨证论治的原则采用加减桑菊饮治疗支气管炎疗效显著,值得进行临床推广。%Objective:To investigate the clinical efficacy of TCD Sangju decoction in treating bronchitis, to provide data support for the clinical use of drugs. Methods:48 cases of bronchitis patients admitted to our hospital from June 2011 to June 2012 were randomly divided into two groups, 24 cases in each group. Experimental group was given addition and subtraction of Sangju decoction according to the principles of TCM;the control group received the treatment of acute bronchitis syrup, after 7 days treatment, comparing the clinical effect of the two groups. Results: The total efficiency of the treatment group was 83.3%, and 66.7% in the control group. There was a significant difference (P<0.05) in two groups. Conclusion:The treatment of bronchitis with addition and subtraction of SangJu decoction which is according to the principles of TCM obtained a significant clinical effects.

  19. An effective analysis of acupoint sticking therapy on prevention of acute chronic bronchitis%穴位贴敷疗法在慢性支气管炎急性发作预防中的疗效分析

    Institute of Scientific and Technical Information of China (English)

    李健瑜; 陈文杰

    2012-01-01

      Objective: To application of acupoint sticking therapy for prevention of chronic bronchitis patients with symptoms of acute clinical effect analysis. Methods: Selected 78 cases suffering from chronic bronchitis patients case, will be divided into control group and treatment group, 39 cases in each group the average. Patients in the control group using conventional antibiotic therapy; patients in the treatment group routine antibiotic therapy combined with acupoint sticking therapy. Results: The treatment group of patients with symptoms of chronic bronchitis curative effect obviously surpasses the comparison group; treatment after a period of illness acute seizures were fewer than those in control group. Conclusion: The application of acupoint sticking therapy for prevention of chronic bronchitis patients with symptoms of acute onset of clinical effect is very obvious.%  目的:对应用穴位贴敷疗法预防慢性支气管炎患者症状急性发作的临床效果进行研究分析。方法:抽取78例患有慢性支气管炎的患者病例,将其分为对照组和治疗组,平均每组39例。对照组患者采用常规抗生素治疗;治疗组患者在常规抗生素治疗基础上加用穴位贴敷疗法进行治疗。结果:治疗组患者慢性支气管炎症状治疗效果明显优于对照组;治疗后一段时间内病情急性发作人数明显少于对照组。结论:应用穴位贴敷疗法预防慢性支气管炎患者症状急性发作的临床效果非常明显。

  20. Analysis of similarity of the SI gene in infectious bronchitis virus (IBV) isolates in Shanghai, China Análisis de similaridad del gen S1 de aislados del virus de la bronquitis infecciosa (IBV) en Shanghai, China

    OpenAIRE

    Zhu, J. G.; H D Qian; Y. L. Zhang; Hua, X.G.; ZL, Wu

    2007-01-01

    The aim of the study was to analyze the similarity of the SI gene in 5 novel viral strains of infectious bronchitis virus (IBV) isolated in Shanghai, China, using a pair of specific primers which were designed based on the published sequences of the S gene of IBV. The 5 full-length cDNA segments of the SI gene were amplified from the 5 isolated strains with RT-PCR. It was confirmed that the nucleotide sequences of the SI gene in the 5 strains isolated from chickens and pigeon have a length of...

  1. Protection induced by infectious laryngotracheitis virus vaccines alone and combined with Newcastle disease virus and/or infectious bronchitis virus vaccines.

    Science.gov (United States)

    Vagnozzi, Ariel; García, Maricarmen; Riblet, Sylva M; Zavala, Guillermo

    2010-12-01

    Two types of live attenuated vaccines have been used worldwide for the control of infectious laryngotracheitis virus (ILTV): 1) chicken embryo origin (CEO) vaccines; and 2) tissue culture origin vaccines (TCO). However, the disease persists in spite of extensive use of vaccination, particularly in areas of intense broiler production. Among the factors that may influence the efficiency of ILTV live attenuated vaccines is a possible interference of Newcastle Disease virus (NDV) and infectious bronchitis virus (IBV) vaccines with the protection induced by ILTV vaccines. The protection induced by CEO and TCO vaccines was evaluated when administered at 14 days of age alone or in combination with the B1 type strain of NDV (B1) and/or the Arkansas (ARK) and Massachusetts (MASS) serotypes of IBV vaccines. Two weeks after vaccination (28 days of age), the chickens were challenged with a virulent ILTV field strain (63140 isolate, group V genotype). Protection was evaluated at 5 and 7 days postchallenge by scoring clinical signs and quantifying the challenge virus load in the trachea using real-time PCR (qPCR). In addition, the viral load of the vaccine viruses (ILTV, NDV, and IBV) was quantified 3 and 5 days postvaccination also using qPCR. The results of this study indicate that the NDV (B1) and IBV (ARK) vaccines and a multivalent vaccine constituted by NDV (B1) and IBV (ARK and MASS) did not interfere with the protection induced by the CEO ILTV vaccine. However, the NDV (BI) and the multivalent (B1/MASS/ARK) vaccines interfered with the protection induced by the TCO vaccine (P vaccines decreased the tracheal replication of the TCO vaccine and the protection induced by this vaccine, since the ILTV-vaccinated and -challenged chickens displayed significantly more severe clinical signs and ILTV load (P vaccinated with the TCO vaccine alone. Although NDV and IBV challenges were not performed, the antibody responses elicited by NDV and/or the IBV vaccinations were significantly

  2. Greatest International ANtiinfective Trial (GIANT with moxifloxacin in the treatment of acute exacerbation of  chronic bronchitis: subanalysis of Chinese data of a global, multicenter, noninterventional study

    Directory of Open Access Journals (Sweden)

    Yulin Feng

    2010-03-01

    Full Text Available Yulin Feng1, Faguang Jin2, Shuang Mu3, Hong Shen4, Xiaohong Yang5, Yuling Wang6, Zhenshan Wang7, Yingjun Kong8, Zuke Xiao9, Qiming Feng101Respiratory Department, West China Hospital, Sichuan University, China; 2Respiratory Department, Tang Du Hospital, China; 3Respiratory Department, Peking University People’s Hospital, China; 4Emergency Department, The General Hospital of the People’s Liberation Army, China; 5Respiratory Department, Xinjiang People’s Hospital, China; 6Respiratory Department, Shi Jiazhuang First Hospital, China; 7Respiratory Department, The Second Affiliated Hospital of Dalian Medical University, China; 8Respiratory Department, The First Clinical College of Harbin Medical University, China; 9Respiratory Department, The Jiangxi Provincial People’s Hospital, China; 10Emergency Department, Shanghai Sixth People’s Hospital, ChinaBackground and objective: A single infective acute exacerbation of chronic bronchitis (AECB has a sustained effect on health status. Although a number of clinical investigations have demonstrated the efficacy of antibiotics in AECB, increased bacterial resistance has caused concern about the efficacy of currently available antibiotic therapies. This subanalysis of a global noninterventional study aimed to evaluate the impact of AECB on the patient and the community and the effectiveness and safety of a treatment with moxifloxacin (MXF tablets in daily life clinical practice in China.Methods: This prospective, noninterventional, noncontrolled, multicenter observational study, which started in China in April 2004 and ended in February 2007, was part of the global GIANT study. Patients with a diagnosis of mild to severe AECB were treated with MXF tablets 400 mg for a period at the physician’s discretion. The observation period for each patient covered a complete treatment period with MXF. For each patient, the physician documented data at an initial visit (baseline and at least one follow-up visit

  3. Observation on the Effect of the Treatment of Children with Recurrent Asthma Bronchitis%孟鲁司特治疗儿童反复哮喘性支气管炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    侯萍萍

    2016-01-01

    Objective:To discuss effect of montelukast in treatment of children recurrent asthmatic bronchiti. Method:From January to June 2014,200 children with recurrent asthmatic bronchitis were selected as research objects and randomly divided into treatment group and control group. The treatment group was given montelukast,4 mg 1 time per night of oral treatment for 6 months. The control group received placebo treatment. To compare the therapeutic effect between the two groups. Result:During the period of 6 months treatment, breathing frequency of symptoms of the treatment group was less than that of the control group,wheezing onset of the respiration rate was lower,breathe course was shorter. The difference was statistically significant(P<0.05). Conclusion:Montelukast can prevent the happening of the repeated sexual bronchitis asthma children breathing, reduce breathing attack,shorten the breathing course.%目的:探讨孟鲁司特治疗儿童反复哮喘性支气管炎疗效。方法:选取本院2014年1-6月收治的200例反复哮喘性支气管炎患儿作为本次研究的对象,随机数字表法分为治疗组与对照组,治疗组给予孟鲁司特4 mg每晚1次口服,治疗6个月,对照组给予安慰剂治疗,观察两组患儿的治疗效果。结果:在治疗的6个月内,治疗组患儿喘息发作的次数较对照组减少,喘息发作时的平均呼吸次数较对照组降低,喘息发作的平均时间较对照组缩短,比较差异有统计学意义(P<0.05)。结论:孟鲁司特可预防反复哮喘性支气管炎患儿喘息的发生,减低喘息发作的次数,降低喘息发作程度,缩短喘息时间。

  4. 穴位贴敷配合中药内服治疗慢性支气管炎疗效观察%Curative Effect Observation of Acupoint Sticking Therapy Combined Orally Traditional Chinese Medicine on Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    黎沛环; 吴锡强; 赵晓燕; 宋黎梅; 王冬云

    2015-01-01

    Objective :To observe the curative effect of the treatment of acupoint application combined with orally traditional Chinese medicine on chronic bronchitis. Methods: Selected 60 cases with chronic bronchitis were divided into control group and treatment group randomly ,30 cases in each group the average. The patients in the control group received acupoint application for 6 times a year in the dog days of summer ,the third nine period after the winter solstice in 3 years in a row. And the ones in the treatment group received acupoint application combined with orally traditional Chinese medicine. Results:The recovery rate and total effective rate were higher in treatment group than those in control group. There was a significant difference between the two groups in their therapeutic effect (P<0.05),and curative effect had a tendency to improve with the increase of number of acupoint sticking therapy and orally traditional Chinese medicine. Conclusion: The treatment of acupoint application com-bined with orally traditional Chinese medicine has good and reliable effect on the prevention and cure of chronic bronchitis.%目的:观察穴位贴敷配合中药内服治疗慢性支气管炎的疗效。方法:选取60例患有慢性支气管炎的患者为研究对象,随机分为对照组和观察组,每组30例。对照组在每年三伏、三九天予以穴位贴敷治疗6次,连续3年;观察组在穴位贴敷基础上给予中药内服治疗。结果:观察组临床治愈率及总有效率均高于对照组,两组疗效比较差异显著(P<0.05),并且随穴位贴敷及内服中药次数的增加,疗效有提高的趋势。结论:穴位贴敷配合中药内服对防治慢性支气管炎有良好的作用。

  5. 氨溴特罗治疗儿童急性支气管炎临床观察%Therapeutic Effect of Ambroxol and Clenbuterol Oral Solutions on Acute Bronchitis in Children

    Institute of Scientific and Technical Information of China (English)

    吴启富

    2012-01-01

    目的:探讨氨溴特罗口服液治疗儿童急性支气管炎的效果.方法:300例急性支气管炎患儿随机分成两组各150例.两组均在控制感染的基础上,治疗组口服氨溴特罗,对照组口服复方福尔可定,疗程5 d.观察两组临床疗效、不良反应和依从性.结果:治疗5 d后,治疗组总有效率(93.33%)明显高于对照组(84.67%),差异有统计学意义(P<0.05);咳嗽、痰量、痰黏稠度、喘息评分、不良反应发生率和依从性等方面比较,差异均有统计学意义(P<0.01或0.05).结论:氨溴特罗治疗急性支气管炎疗效显著,安全可靠,依从性好.%Objective: To evaluate the therapeutic effects of ambroxol and clenbuterol oral solutions on acute bronchitis in children. Method: Totally 300 cases with acute bronchitis were randomly divided into the treatment group ( 150 cases ) and the control group ( 150 cases). On the basis of anti-inflammatory therapy, ambroxol and clenbuterol oral solutions were given in the treatment group and pholcodine syrups were used in the control group for 5 days. The therapeutic effects, adverse reactions and compliance of the two groups were assessed. Result: After the treatment,the total effective rate of the treatment group( 93. 33% )was higher than that of the control group ( 84. 67% )( P<0. 05 ). The effects on cough,sputum volume,sputum viscosity and wheezing were much better in the treatment group than those in the control group( P<0. 01 ). There were significant statistic differences in the adverse reactions and compliance between the two groups( P<0. 05 ). Conclusion: Ambroxol and clenbuterol oral solutions are safe, convenient and highly effective in the treatment of acute bronchitis in children.

  6. 慢性支气管炎急性发作患者痰病原学及耐药性分析%Sputum pathogens and drug resistance analysis of patients with acute exacerbations of chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    高成兵; 杨伟; 汪平; 幸仕洪; 王珏

    2013-01-01

    Objective Study on acute exacerbation of chronic bronchitis patients and drug resistance of pathogenic data. Methods Respiratory department of our hospital from 2010 January to 2010 December, 623 cases of acute exacerbation of chronic bronchitis treated with routine of sputum pathogenic detection. All experimental strains were API system for bacterial identification , using the disc diffusion method, according to the CLS1 drug sensitive test of antibacterial drug grouping principle. Results Qualified sputum samples were isolated from the strain of 448 strains of Gram-negative bacteria, which accounted for the main, Pseudomonas most 18. 4%. The detection of ESBL enzyme-producing strains of 13 strains of,mainly produced by a Pseudomonassp; MRSA enzyme-producing strain 5, all produced by staphylococcus; Multiple drug resistance of Acinetobacter strains of 8, mainly produced by Bauman acinetobacter. Conclusion Patients with acute exacerbations of chronic bronchitis pathogens in Gram-negative bacteria accounted for a major. The situation is more serious and resistance, clinicians should pay more attention.%目的 研究慢性支气管炎急性发作患者的病原学资料及耐药情况.方法 我院自2010年1月~2010年12月收治623例慢性支气管炎急性发作的患者,常规开展痰液病原学检测,所有实验菌株均以API系统进行细菌鉴定,采用纸片扩散法,按CLSI药敏试验抗菌药物分组原则进行.结果 合格痰液标本共分离出菌株448株,其中革兰氏阴性菌占主要,假单胞菌最多,达18.4%.其中,检出产ESBL酶菌株13株,主要由假单胞菌产生;产MRSA酶5株,全部由葡萄球菌产生;多重耐药不动杆菌8株,主要由鲍曼不动杆菌产生.结论 慢性支气管炎急性发作患者病原菌中革兰氏阴性菌占主要,且耐药情况较为严重,应引起临床高度重视.

  7. Clinical Analysis of ShuLiyi to Treat Chronic Bronchitis Acute Onset%舒利迭治疗慢性支气管炎急性发作的临床分析

    Institute of Scientific and Technical Information of China (English)

    徐亦农

    2013-01-01

    Objective:To investigate the ShuLi idea for treatment of chronic bronchitis acute episodes. Methods:A retrospective analysis from January 2010 to March 2010 were treated 140 cases of patients with chronic bronchitis acute clinical cases, according to random method the 140 patients were divided into treatment group and control group, 70 cases in each group, the treatment group patients on the basis of conventional treatment combined with ShuLi overlapping (salmeterol assigned powder inhalant), control group patients only routine phlegm treatment, compared two groups of patients in the therapeutic effect and adverse reactions. Results:The treatment group patients clinical treatment effect is better than that of control group (P<0.05), statistically significant difference between the two groups of patients. Conclusion:ShuLi overlapping (salmeterol assigned powder inhalant) can be effective for the treatment of chronic bronchitis acute episodes, good safety, small adverse reactions, worthy of popularization and application in clinic.%目的:探讨舒利迭治疗慢性支气管炎急性发作的临床效果。方法:回顾性分析我院2010年1月~2013年3月收治的140例慢性支气管炎急性发作患者的临床病例,按照随机的方法将这140例患者分为治疗组及对照组,每组70例,治疗组患者在常规治疗的基础上加用舒利迭(沙美特罗替卡松粉吸入剂),对照组患者仅行常规化痰治疗,比较两组患者的治疗效果及不良反应。结果:治疗组患者的临床治疗效果优于对照组(P<0.05),两组患者间差异具有统计学意义。结论:舒利迭(沙美特罗替卡松粉吸入剂)可有效的治疗慢性支气管炎急性发作,安全性好,不良反应小,值得在临床上推广应用。

  8. Clinical Observation of Yinqiao Zhisou Powder in Treating Acute Onset of Chronic Bronchitis%银翘止嗽散治疗慢性支气管炎急性发作期临床观察

    Institute of Scientific and Technical Information of China (English)

    汤宏涛

    2012-01-01

    Objective:To observe the clinical efficacy of Yinqiao Zhisou Powder in treating acute onset of chronic bronchitis. Methods;80 cases who were diagnosed as acute onset of chronic bronchitis were given Yinqiao Zhisou Powder ( Composition; honeysuckle 30 g, for-sythia 20 g,the Aster 15 g,Radix Stemonae 15 g,radix cynanchi 10 g,Coltsfoot 10 g,radix scutellariae 10 g,prepared Ephedra 10 g,the Campanulaceae 15 g,licorice 5 g) for treatment with water decoction,one dose per day and 10 d for a course of treatment. All cases were treated for one to two courses. Results;37 cases were cured;28 cases were markedly effective;13 cases were effective;2 cases were ineffective. The effective rate was 97.5%. Conclusion: Yinqiao Zhisou Powder has significant effect in treating acute onset of chronic bronchitis.%目的:观察自拟银翘止嗽散治疗慢性支气管炎急性发作期的临床疗效.方法:80例确诊病例采用银翘止嗽散(方药组成:金银花30 g,连翘20 g,紫菀15 g,百部15 g,白前10 g,款冬花10 g,黄芩10 g,炙麻黄10 g,桔梗15 g,甘草5 g)治疗,水煎服,日1剂,10 d为1个疗程,全部病例治疗1~2个疗程.结果:治愈37例,显效28例,有效13例,无效2例,有效率为97.5%.结论:银翘止嗽散治疗慢性支气管炎急性发作疗效显著.

  9. 多索茶碱联合氨溴索治疗慢支急性发作的疗效观察%To Observe the Curative Effect of Doxofylline Combined With Ambroxol on Acute Attack of Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    矫维荣

    2015-01-01

    目的:探讨多索茶碱联合氨溴索治疗慢性支气管炎急性发作的临床疗效。方法入选我院2013年1月~2014年1月慢性支气管炎急性发作的患者80例,随机分为两组,观察组和对照组各40例,观察组给予多索茶碱联合氨溴索治疗,对照组单纯给予氨溴索治疗,观察两组的临床效果。结果治疗后,观察组与对照组相比,咳嗽、痰液消失的时间、干湿性啰音消失的时间,P<0.05,差异具有统计学意义。两组患者治疗的总有效率比较,观察组高于对照组,P<0.05,差异具有统计学意义。结论多索茶碱与氨溴索联合治疗慢性支气管炎急性发作效果显著,安全性高,不良反应少。%Objective To investigate the clinical effect of doxofylline combined with ambroxol treatment of acute attack of chronic bronchitis. Methods Selected 80 patients with acute attack of chronic bronchitis patients in our hospital, the observation group was given doxofylline combined with ambroxol treatment, the control group only received ambroxol treatment, to observe the clinical effects of two groups.Results Cough, sputum, dry time of the disappearance of rales disappear time signiifcantly statistical difference, total effective rate of observation group is obviously higher than that in control group. Conclusion Doxofylline combined with ambroxol treatment of acute exacerbation of chronic bronchitis the effect signiifcantly.

  10. 中西医结合治疗慢性支气管炎急性发作的临床分析%Clinical Analysis of Integrated Medicine in the Treatment of Acute Exacerbation of Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    王守振

    2015-01-01

    Objective Discussing method and clinical effect of integrated medicine in the treatment of acute exacerbation of chronic bronchitis, and summarizing experience to improve treatment level of oneself .Method 140 case of patients with acute exacerbation of chronic bronchitis in our department from May 2012 to May 2014 were randomly divided into control group and observation group .The control group was given Weston medicine .On the basis of the control group , the observation received Xiaoqinglong decoction additionally .The treatment result was recorded and statistically analyzed .Result The total effective rate of the observation group and the control group was 85.71%and 98.57%, respectively , and the difference was statistically significant ( P <0.05 ) .Conclusion The clinical effect of integrated medicine in the treatment of acute exacerbation of chronic bronchitis was superior to the individual effect of the Weston medicine , and was worthy of clinical further research and promotion .%目的:探讨中西医结合治疗慢性支气管炎急性发作的方法及其临床疗效,总结经验以提高自身治疗水平。方法将2012年5月—2014年5月我科收治的140例慢性支气管炎急性发作患者随机分成对照组和观察组,对照组给予单纯西医治疗,观察组在对照组基础上加用小青龙汤加减治疗,记录两组患者治疗结果并进行统计学分析。结果对照组、观察组的总有效率分别是85.71%、98.57%,二者差异具有统计学意义(P<0.05)。结论中西医结合治疗慢性支气管炎急性发作的临床疗效明显优于单纯西医治疗,值得在临床上进一步研究,加强推广。

  11. 对小儿急慢性支气管炎患儿进行特殊护理的临床研究%Clinical study of special nursing for children with acute and chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    齐金华

    2015-01-01

    AIM: To investigate the clinical effect of special nursing for children with acute or chronic bronchitis. METH⁃ODS: A total of 78 children with acute or chronic bronchitis admitted to our hospital from April 2014 to March 2015 were selected and divided into two groups based on the nursing method, with 39 cases in each group. RESULTS: The cure rate of the observation group was significantly higher than that of the control group (P<0.05), and the nursing satisfaction was significantly higher than that of the control group ( P<0. 05 ) . CONCLU⁃SION:To imply special nursing for children with acute or chronic bronchitis can increase the cure rate, improve the nursing satisfaction, and reduce the incidence of complications.%目的:探讨对小儿急慢性支气管炎患儿进行特殊护理的临床效果.方法:选取2014-04/2015-03我院收治的小儿急慢性支气管炎患儿78例,按照护理方法分成观察组( n=39)和对照组( n=39).观察组采用特殊护理,对照组采用常规护理,观察比较两组治愈率、护理满意度和并发症发生率.结果:观察组患儿治愈率明显高于对照组(P<0.05),护理满意度明显高于对照组(P<0.05),并发症发生率明显低于对照组( P<0.05).结论:对小儿急慢性支气管炎患儿进行特殊护理,能够提高患儿治愈率,提高护理满意度,降低并发症发生率.

  12. Analysis of the effect of ambroxol hydrochloride in the treatment of acute exacerbation of chronic bronchitis%盐酸氨溴索治疗慢性支气管炎急性发作的疗效分析

    Institute of Scientific and Technical Information of China (English)

    丁宁

    2014-01-01

    目的:观察盐酸氨溴索对慢性支气管炎急性发作的临床疗效。方法:选取2012年11月-2014年3月慢性支气管炎急性发作患者60例,随机分为对照组30例和试验组30例。对照组给予吸氧、抗感染、解痉平喘等常规治疗;试验组在常规治疗基础上加用盐酸氨溴索静脉滴注,每次30 mg,每日2次,5 d为1个疗程,共2个疗程,治疗结束后比较两组疗效。结果:试验组的总有效率为96.75%,对照组为76.7%,组间差异有统计学意义(P<0.05)。结论:盐酸氨溴索治疗慢性支气管炎急性发作有较好的临床疗效。%Objective:To observe the clinical effect of ambroxol hydrochloride in the treatment of acute exacerbation of chronic bronchitis. Methods: Sixty cases with acute exacerbation of chronic bronchitis were selected from Nov. 2012 to March 2014 and divided into a control group with 30 patients and an experiment group with 30 patients at the random. The control group was treated with oxygen inhalation, anti-infection, antispasmodic and the conventional therapy. The experiment group was added with ambroxol hydrochloride injection of 30 mg every time, twice a day, 5 days a course for 2 courses based on the conventional therapy. The treatment effects of two groups were compared after the treatment. Results:The total efifcacy was 96.7% in the experiment group, and 76.7% in the control group. The difference of the two groups had the statistical signiifcance (P<0.05). Conclusion:Ambroxol hydrochloride has a good clinical effect in the treatment of acute exacerbation of chronic bronchitis.

  13. Therapeutic Effect of Budesonide Inhalation on Acute Infectious Laryngitis and Bronchitis%布地奈德吸入治疗急性喉炎、喉气管支气管炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    韩明达

    2015-01-01

    目的:分析探讨布地奈德吸入治疗急性喉炎、喉气管支气管炎症的临床效果。方法选取88例患有急性喉炎、喉气管支气管炎的患者作为研究对象,将其随机分成对照组和观察组,每组44例患者。对照组患者采用地塞米松静脉注射进行治疗,观察者则采取布地奈德雾化吸入进行治疗;治疗结束后,对比两组患者的治疗效果。结果采取布地奈德雾化吸入治疗的观察组患者在治疗效果及症状缓解上明显优于对照组,P<0.05,差异具有统计学意义。结论采用布地奈德雾化吸入治疗急性喉炎、喉气管支气管炎具有显著的治疗效果,患者症状能够得到迅速恢复。%Objective To explore the clinical effect analysis of budesonide inhalation in the treatment of acute laryngitis, bronchitis disease. Methods 88 cases with acute laryngitis, bronchitis of children as the research object, and were randomly separated into the observation group and the control group, 44 cases in each group of patients. The control group was treated with intravenous dexamethasone treatment, observers take budesonide inhalation treatment,in the end of the treatment, compared two groups of patients with treatment effect.Results Take budesonide atomization inhalation treatment observation group patients in the treatment and remission of symptoms signiifcantly better than the control group,P<0.05,with significant difference.Conclusion Inhalation in the treatment of acute laryngitis, bronchitis has signiifcant therapeutic effect of budesonide in children with symptoms, can be quickly restored.

  14. 盐酸氨溴索用于慢性支气管炎急性加重期的疗效%Efficacy of ambroxol hydrochloride on acute anabasis of chronic bronchitis patients

    Institute of Scientific and Technical Information of China (English)

    张鑫

    2012-01-01

    目的 观察盐酸氨溴索辅助治疗慢性支气管炎急性加重期患者的气道净化疗效.方法 选择2009年10月-2011年10月在我科治疗的慢支急性发作患者80例,随机分成治疗组和对照组,各40例,治疗组给予抗生素+盐酸氨溴索30 mg,2次/d静点,对照组单纯使用抗生素,两组基础治疗相同,比较两组治疗后临床症状、体征、实验室检查恢复情况.结果 治疗组总有效率为97.5%,对照组为85%,两组比较,差异有统计学意义(P<0.01).结论 盐酸氨溴索静脉用药辅助治疗慢支急性发作可明显化痰、祛痰,改善呼吸,缩短病程,且药物不良反应小.%Objective To observe the airway purification effect of ambroxol hydrochloride in acute anabasis of chronic bronchitis patients. Methods 80 patients with acute attack of chronic bronchitis who cured in our department from October 2009 to October 2011 were selected. The patients were randomly divided into treatment group and control group with 40 cases in each group. Treatment group was given antibiotics + hydrochloride ammonia bromide cable 30 mg ductus venosus twice a day; Control group was only given antibiotics. The basic treatment of the two groups was the same. The clinical symptoms, signs, and laboratory check recovery situation of the two groups after treatment were compared. Results The total effective rate of treatment group and control group were 97. 5% and 85% respectively (P < 0. 01). Conclusion Ambroxol hydrochloride has good effect on the patients with acute exacerbation of chronic bronchitis by clearing phlegm,expectorant,improving breathing,shortening the course with few side effect.

  15. Watercress Formula for Chicken Kidney Type Infectious Bronchitis%荆芥组方对鸡肾型传染性支气管炎防治效果观察

    Institute of Scientific and Technical Information of China (English)

    冯善祥

    2011-01-01

    We used the method of randomization and duplication of pathological model to do this research. In order to validate the effects of the compound preparation of Chinese traditional medicine to the avian infectious bronchitis, we divided the 2-week-old AA kreo-chicken into 8 groups (30 chicken for each group), including the investigational drug groups (which include the high dose group and the moderate dose group as well as the low dose group) and the following control groups: the control group of traditional Chinese medicine and the Western medicine group, the vaccine control group and the negative control group as well as the health control group. The chickens were artificially infected with infectious bronchitis virus (IBV) to observe the protection of the compound preparation of Chinese traditional medicine. The results indicated that the compound preparation of Chinese traditional medicine has a great protection to chicken infected by (IBV). Therefore, the compound preparation of Chinese traditional medicine can be used to the prevention and cure of avian infectious bronchitis.%本试验采取随机分组,病理模型复制的方法,试验中将14日龄AA肉雏鸡240只随机分为受试药物组(高、中、低3个剂量)、中药对照组、西药对照组、疫苗对照组、阴性对照组、健康对照组共8个组,每组30只,以验证中药荆芥组方对鸡肾型传染性支气管炎的效果.将试验鸡人T感染肾型传染性支气管炎病毒(IBV),观察中药组方对雏鸡保护作用.结果表明,本组方对肾型传染性支气管炎病毒感染雏鸡具有明显的保护作用,可以用于鸡肾型传染性支气管炎的预防和治疗.

  16. The clinical analysis of 32 cases of chronic bronchitis acute attacking by MRSA infection%MRSA 感染致慢性支气管炎急性发作32例临床分析

    Institute of Scientific and Technical Information of China (English)

    高成兵

    2013-01-01

    Objective: To analyze the clinical effect of treating chronic bronchitis acute at acking by MRSA infection. Methods: Choosed 32 cases of chronic bronchitis acute at acking by MRSA infection from Dec. 2010 to Dec. 2012 to sputum culture experiment and drug sensitive test and treat with vancomycin. Results: The antibiotic susceptible rate of MRSA was 100.0%, the effective rate of study group was 93.8%, adverse rate was 6.2%. Conclusion: There is high rate in primary hospital of chronic bronchitis acute at acking by MRSA infection, but MRSA is sensitive to vancomycin.%目的:分析 MRSA(耐甲氧西林金黄色葡萄球菌)感染所致慢性支气管炎急性发作期相关情况。方法:回顾性分析2010年12月-2012年12月大邑县人民医院呼吸科住院的慢性支气管炎急性发作期的 MRSA 感染患者32例,均行痰培养实验和药敏试验,并均采用万古霉素治疗,统计药敏试验结果和临床治疗情况。结果:MRSA 对万古霉素的敏感率达100.0%;治疗总有效率93.8%,不良反应率为6.2%,临床效果比较显著。结论:基层医院中社区获得性感染致慢性支气管炎的急性发作患者中也存在较高比率的 MRSA 感染;MRSA 对万古霉素敏感,尚未发现有耐药株。

  17. PM2.5浓度对老年慢性支气管炎急性发作的影响%Research PM2.5 concentration on acute onset of chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    翟文慧; 李勇; 路晶凯; 王伟; 黄志刚

    2015-01-01

    Objective To investigate the effect of PM2.5 concentration on acute onset of chronic bronchitis. Method The clinical data of Beijing city center and other areas were selected to monitor and record daily fine particulate air pollution around the station PM2.5, PM10 concentrations, and the average temperature, maximum temperature, minimum temperature, wind speed, relative humidity, barometric pressure, visibility seven meteorological factors. The number of cases of chronic bronchitis in patients with acute exacerbation everyday was recorded. Result ①Daily hospital visits attack was positively correlated with the concentration of PM2.5, with the average, maximum and minimum temperatures were negatively correlated, and the minimum temperature associated with relatively greater;same barometric pressure, relative humidity, wind speed and visibility were negatively correlated.②The number of acute exacerbation of chronic bronchitis as PM2.5 level increased and growth. Conclusion Acute exacerbation of chronic bronchitis affected by the concentration of PM2.5, PM2.5 concentration monitoring can play a role in early warning of the onset of senile acute and chronic respiratory diseases.%目的:探讨PM2.5浓度对老年慢性支气管炎急性发作的影响。方法选择北京市城市中心区及其他地区的患者资料,监测并记录每日医院周围大气细颗粒污染物PM2.5和PM10的浓度以及平均气温、最高气温、最低气温、风速、相对湿度、气压、能见度等7项气象因子。记录两地区每日老年慢性支气管炎急性发作患者例数。结果①每日住院的老年慢性支气管炎急性发作患者例数同PM2.5浓度呈正相关,同平均气温、最高气温、最低气温均呈负相关,且与最低气温相关度更大;同气压、相对湿度、风速及能见度均呈负相关。②老年慢性支气管炎急性发作患者例数随PM2.5等级升高而增多。结论老年慢性

  18. 十味龙胆花胶囊辅助治疗小儿急性支气管炎疗效观察%Ten flavour gentian flowers capsule auxiliary treatmentof infantile acute bronchitis curative effect observation

    Institute of Scientific and Technical Information of China (English)

    张晓红

    2015-01-01

    目的:观察十味龙胆花胶囊辅助治疗小儿急性支气管炎的临床疗效。方法将小儿急性支气管炎患儿108例,从咳嗽、咳痰、喘息、肺部哮鸣音等方面观察治疗前后和2组间变化,并以记分的形式进行统计学处理。随机分为治疗组、对照组各54例,均采用抗感染、平喘、雾化吸入等综合治疗,治疗组在此基础上加服十味龙胆花胶囊。结果2组治疗后积分均显著高于治疗前(P<0.05);治疗组积分显著高于对照组(P<0.05)总有效率87.0%,对照组总有效率59.3%。两组经统计学分析,差异有统计意义(P<0.05)。结论十味龙胆花胶囊是治疗小儿急性支气管炎的有效药物,有改善急性支气管炎急性发作的咳、痰、喘、炎的作用。%Objective To observe the ten taste auxiliary gentian flowers capsule in the treatment of infantile acute bronchitis curative effect. Methods 108 cases of children with acute bronchitis, children from cough, sputum, breathing and lung wheezing sound observation and changes between the two groups before and after the treatment, and in the form of scoring statistics processing. Were randomly divided into treatment group and the control group (n = 54), adopt anti-infection, smooth wheezing, atomization inhalation comprehensive treatment, the treatment group on the basis of gentian flowers capsule add ten taste. Results two groups after treatment points were significantly higher than before treatment (P <0.05); Integral treatment group is significantly higher than control group (P<0.05), total effective rate 87.0%, control group total effective rate was 59.3%. Statistically significant difference after statistics analysis, the two groups (P<0.05).Conclusion 10 flavour gentian flowers capsule effective therapeutic agents in the treatment of children with acute bronchitis, improved acute bronchitis acute cough, phlegm, asthma, the role of inflammation.

  19. Xingsu San Adjustment Treatment of Pediatric Acute Bronchitis 60 cases of Clinical Observation%杏苏散加减治疗小儿急性支气管炎60例临床观察

    Institute of Scientific and Technical Information of China (English)

    崔松涛

    2015-01-01

    目的:探讨杏苏散加减治疗小儿急性支气管炎的效果。方法:把我院收治的小儿支气管炎患儿60例平均分成两组,治疗组用杏苏散加减,对照组应用头孢曲松、地塞米松、病毒性静脉滴注,比较疗效。结果:治疗组痊愈率为95%,对照组为60%,差异明显。结论:杏苏散加减治疗小儿急性支气管炎,疗效满意,且无不良反应,较之西药治疗可以有效缩短治疗时间,避免患儿病情加重,减轻患儿痛苦,值得临床工作者推广使用。%Objective:To investigate the Xingsu San Decoction for the treatment of children with Acute Bronchitis effect. Methods: Our Hospital pediatric bronchiolitis were 60 patients divided into two groups, treatment group with apricot Su powder the addition and subtraction, control group used cephalosporin ceftriaxone, dexamethasone,virus of intravenous injection,the curative effect was compared. Results:The cure rate of treatment group was 95%,60% in the control group, the difference is obvious.Conclusion:Xingsu San Decoction for the treatment of acute bronchitis in children, the curative effect is satisfied, and no adverse reactions,compared to western medicine treatment can effectively shorten the treatment time, avoid exacerbations in children, reduce the pain of patients, it is worth to promote the use of clinical workers.

  20. Pharmaceutical Care for One Elderly Patient with Acute Bronchitis Associated with Cerebral Arteriosclerosis%1例老年急性支气管炎并脑动脉硬化患者的药学监护

    Institute of Scientific and Technical Information of China (English)

    张富东

    2014-01-01

    目的:探讨临床药师参与药物治疗方案的制订与药学监护的方法。方法:介绍临床药师参与1例老年急性支气管炎并脑动脉硬化患者的治疗过程,分析、评价治疗方案,提出药学建议,并进行药学监护。结果:通过药师的介入与参与可使患者的治疗更加顺利,真正做到了对老年急性支气管炎并脑动脉硬化患者的治疗个体化,使患者顺利治愈出院。结论:临床药师的参与可以协助医师制订安全、有效的治疗方案。%OBJECTIVE:To explore the approaches for clinical pharmacist to participate in the formulation of treatment regi-men and carry out pharmaceutical care. METHODS:Clinical pharmacist’involvement in the treatment of one elderly patient with acute bronchitis associated with cerebral arteriosclerosis was introduced with regard to his efforts in analyzing and evaluating thera-peutic regimen,putting forward pharmacy suggestion and providing pharmaceutical care. RESULTS:Pharmacist’s involvement con-tributed to smooth treatment of the patient and effectuated the individualized treatment for the elderly patient with acute bronchitis associated with cerebral arteriosclerosis and the patient was cured and discharged from hospital. CONCLUSIONS:Clinical pharma-cist’s involvement can help clinical physicians in formulating safe and effective treatment regimen.

  1. 慢性支气管炎合并肺炎患者血浆中D-二聚体检测的临床意义%Clinical significance of plasma D-dimer detection in chronic bronchitis complicated with pneumonia patients

    Institute of Scientific and Technical Information of China (English)

    刘海波

    2015-01-01

    目的:探讨慢性支气管炎合并肺炎患者血浆中D-二聚体检测的临床意义。方法慢性支气管炎急性发作合并肺炎患者64例和肺栓塞患者30例,对其D-二聚体进行快速定量测定。结果慢性支气管炎急性发作合并肺炎患者和肺栓塞患者D-二聚体差异无统计学意义(P>0.05)。结论检测D-二聚体为判断慢性支气管炎是否合并肺部感染有一定的意义,且有助于判断炎症的轻重及病情变化。%Objective To investigate clinical significance of plasma D-dimer detection in chronic bronchitis complicated with pneumonia patients.Methods There were 64 cases of chronic bronchitis acute attack complicated with pneumonia and 30 cases of pulmonary embolism. Rapid quantitative determination was made for D-dimer in all patients.Results The difference of D-dimer had no statistical significance between chronic bronchitis acute attack complicated with pneumonia patients and pulmonary embolism patients (P>0.05). Conclusion Detection of D-dimer provides certain value for judging whether chronic bronchitis is complicated with pulmonary infection. This method is also helpful to judging status of inflammation and disease.

  2. 高渗盐水雾化吸入治疗毛细支气管炎临床观察%Clinical observation on hypertonic saline aerosol inhalation in treatment of capillary bronchitis

    Institute of Scientific and Technical Information of China (English)

    成红霞; 彭小红; 魏惠兰; 李萍; 韩玲; 赵永芳

    2013-01-01

    Objective To discuss the treatment effect of atomizing inhaled hypertonic saline and ammonia bromine treatment for capillary bronchitis .Methods Totally 60 cases of capillary bronchitis patients were randomly divided into hypertonic saline group ( therapy group ) , ammonia bromine group(control group 1) and conventional group(group 2) with 20 cases in each group.Control group 2 was only given conventional treatment .On the basis of conventional treatment , control group 1 and therapy group was provided with atomization inhaling ammonia bromine 7.5 mg and hypertonic saline 4 ml, respectively.They were given one time every 8 hours(q8h) and the course was 1 week.Comparison was made in clinical coughing , gasping suppress , pulmonary symptoms disappearance time and hospital stay among three groups .Results All of 60 cases were cured and discharged , and the therapeutic effect of the therapy group ( hypertonic saline group) was significantly superior to that of the other two groups .There were statistical differences in wheezing disappearance , cough disappearance , sign disappearance and hospitalization stay among three groups ( t1 value was -9.173, -3.252, -9.672 and -3.968 respectively, all P<0.01;t2 value was -7.952, -2.0433, -8.114 and -4.793 respectively,all P<0.01) Conclusion Hypertonic saline aerosol inhalation in treatment of capillary bronchitis is better than ammonia bromine atomizing inhalation .%目的探讨雾化吸入高渗盐水和氨溴索治疗毛细支气管炎的效果。方法将60例毛细支气管炎患儿随机分为高渗盐水组(治疗组)、氨溴索组(对照1组)和常规组(对照2组),每组各20例,治疗组和对照1组在常规治疗基础上分别给雾化高渗盐水4mL或吸入氨溴索7.5mg,每8小时1次(q8h),连用1周,对照2组仅常规治疗。比较临床咳嗽、喘憋、肺部体征消失时间、住院时间等。结果60例患儿均治愈出院,治疗组疗效明显优于对照1组和对照2

  3. Clinical observation on hypertonic saline aerosol inhalation in the treatment of cap-illary bronchitis%高渗盐水雾化吸入辅助治疗毛细支气管炎的临床观察

    Institute of Scientific and Technical Information of China (English)

    黄李斐; 何樨

    2015-01-01

    Objective To discuss the treatment effect and safety of atomizing inhaled hypertonic saline for capillary bronchitis .Meth‐ods Totally 200 cases of capillary bronchitis patients were randomly divided into therapy group and control group .On the basis of conventional treatment ,the control group was provided with atomization inhaling ambroxol 15 mg dissolved in normal saline and the therapy group was provided with atomization inhaling 30 g · L -1 hypertonic saline .Comparison was made in clinical coughing , gasping suppress ,pulmonary symptoms disappearance time and hospital stay . Results The therapeutic effect of the therapy group ,with 97 .0% efficiency ,was significantly superior to the control group (82 .0% ) .There was statistical difference in wheezing disappearance ,cough disappearance ,sign disappearance and hospitalization stay .There was no harmful incident occurred during the atomization inhaling in all the patients .Conclusion The treatment effect and safety of atomizing inhaled hypertonic sa‐line for capillary bronchitis was definite ,and it was effective to relieve the clinical symptoms and shorten the hospital stays .%目的:考察高渗盐水雾化吸入辅助治疗婴幼儿毛细支气管炎的临床疗效和安全性。方法选择我院2012年1月~2014年6月收治的毛细支气管炎住院患儿200例,随机分为对照组与治疗组,在对症治疗的基础上,对照组给予氨溴索15 m g溶解于生理盐水中雾化吸入,治疗组患儿给予30g · L -1氯化钠雾化吸入,观察2组患者的临床治疗效果和安全性。结果治疗组临床总有效率为97.0%,显著高于对照组的82.0%,治疗组患儿的临床症状和体征(咳嗽气喘、哮鸣音、肺部湿罗音)消失时间和平均住院时间均显著短于对照组;且2组患儿在雾化吸入过程中均未发生不良事件。结论高渗盐水雾化吸入辅助治疗婴幼儿毛细支气管炎的效果确切,可有效缓解

  4. Clinical observation of acute exacerbation of chronic bronchitis treated by Shenbai Zhike mixture%参百止咳合剂治疗慢性支气管炎急性发作30例临床观察

    Institute of Scientific and Technical Information of China (English)

    闫国友; 张立民; 王兴

    2011-01-01

    目的 观察在西医常规治疗基础上应用参百止咳合剂治疗慢性支气管炎急性发作的临床疗效.方法 将60例慢性支气管炎急性发作患者随机分为2组,对照组30例予西医常规治疗,治疗组30例在对照组治疗基础上予参百止咳合剂治疗,2组均7d为1个疗程,治疗2个疗程后观察疗效,进行症状积分及实验室指标血清白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)比较.结果 治疗组总有效率90.0%,对照组总有效率80.0%,2组总有效率比较差异有统计学意义(P<0.05),治疗组疗效优于对照组.2组治疗后症状积分均较本组治疗前降低(P<0.05),且治疗组治疗后症状积分低于对照组(P<0.05).2组治疗后血清IL-8、TNF-α水平均较本组治疗前降低(P<0.05),且治疗组治疗后血清IL-8、TNF-α水平低于对照组(P<0.05).结论 参百止咳合剂治疗慢性支气管炎急性发作疗效确切,值得临床推广.%Objective To investigate the clinical effect of acute exacerbation of chronic bronchitis treated by Shenbai Zhike mixture. Methods 60 patients with acute exacerbation of chronic bronchitis were randomly divided into two groups. Patients in control group received routine western medicine. Patients in treatment group were treated by Shenbai Zhike mixture combined with routine western medicine. The course was seven days in two groups. After two courses the curative effect was observed. Symptoms score, IL - 8 and TNF -α were compared for evaluation of clinical effect. Results The total effective rate in treatment group (90.0% ) was higher than that in control group (80.0% , P <0.05). The symptoms score after treatment was decreased in compared with that before treatment in two groups ( P <0.05). And the symptoms score in treatment group was lower than that in control group after treatment ( P < 0.05 ). The levels of IL - 8 and TNF - α in treatment group were lower than those in control group after treatment ( P <0

  5. Observation of acute attack stage of chronic bronchitis treated by Zhikepingchuan prescription%止咳平喘方治疗慢性支气管炎急性发作期120例疗效观察

    Institute of Scientific and Technical Information of China (English)

    刘秀艳; 刘俊敏; 程国静; 刘宏

    2014-01-01

    目的:观察止咳平喘方治疗慢性支气管炎急性发作期的临床疗效。方法将240例慢性支气管炎急性发作期患者随机分为2组,对照组120例予西医常规治疗,治疗组120例在对照组治疗基础上加止咳平喘方治疗。治疗10 d后观察2组治疗前后肺功能指标第1 s用力呼气容积占预计值百分比( FEV1%)和FEV1/用力肺活量( FVC),并观察治疗前后咳嗽、咯痰、喘息等临床症状变化以评价临床疗效。结果治疗组总有效率93.33%,对照组总有效率82.50%,2组总有效率比较差异有统计学意义(P<0.05),治疗组临床疗效优于对照组。治疗组治疗后肺功能指标FEV1%及FEV1/FVC与本组治疗前及对照组治疗后比较均明显提高(P<0.05)。结论止咳平喘方治疗慢性支气管炎急性发作期,肺功能改善明显,疗效确切,患者耐受良好,安全性高。%Objective To observe the clinical effect of acute attack stage of chronic bronchitis treated by Zhikepingchuan prescription .Methods 240 patients with acute attack stage of chronic bronchitis were randomly di-vided into control group ,which was treated by routine therapy and treatment group ,which was treated by Zhikeping-chuan prescription on the basis of control group treatment .Pulmonary function indicatrix ( FEV1% and FEV1/FVC) were observed after 10 days of treatment.The changes of clinical symptoms such as cough ,sputum,breathing before and after treatment were observed and clinical effect was evaluated .Results The total effective rate in treatment group (93.33%)was higher than that in control group (82.50%,P<0.05).FEV1% and FEV1/FVC in treatment group were increased as compared with those in control group after treatment ( P<0 .05 ) .Conclusion Zhikeping-chuan prescription on the treatment of acute attack stage of chronic bronchitis can significantly improve patients with lung function,definite curative effect,well tolerated

  6. Effect of nursing intervention on the treatment of children with acute bronchitis in the outpatient department%护理干预对门诊急性支气管炎患儿治疗效果的影响

    Institute of Scientific and Technical Information of China (English)

    尤丽亚; 朱雪凤; 朱彩勤

    2012-01-01

    目的 探讨护理干预对门诊急性支气管炎患儿临床疗效的影响.方法 将120例急性支气管炎的门诊患儿随机分为综合护理干预组60例和对照组60例.两组均进行常规治疗与护理,干预组在此基础上进行治疗、预防、保健、认知等综合护理干预.对两组临床表现、治疗效果进行评价.结果 用药后治疗效果干预组显效率达51.67%,高于对照组33.33%;总有效率干预组为81.67%,高于对照组71.67%,差异有统计学意义(x2=4.19,P<0.05).临床表现患儿的咳嗽消失、痰鸣音消失、湿啰音消失及体温降至正常的天数干预组均少于对照组,差异有统计学意义(P<0.05).结论 护理干预对门诊急性支气管炎患儿的治疗能够增强疗效,尽快缓解患儿症状,缩短病程,提高治愈率,值得在临床推广.%Objective To investigate the effects of nursing intervention on the treatment of children with acute bronchitis in the outpatient department.Methods 120 cases of children diagnosed with acute bronchitis in the outpatient department were randomly selected and divided into intervention group and control group. Both groups received routine therapy and nursing. Intervention group was treated with nursing intervention including treatment,prevention,health care,and cognition.Clinical manifestations and treatment effects were evaluated for two groups.Results Treatment effects for the intervention group was 51.67% and significantly higher than the control group (33.33% ); The total efficacy for the intervention group is significantly higher than that for the control group (81.67% vs 71.67% respectively; x2 =4.19,P <0.05).In terms of clinical manifestations,significant more patients had disappeared coughing,Wheezy phlegm,wet rales,less days for body temperature return to normal in the intervention group than in the control group (P<0.05).Conclusions Nursing intervention for acute bronchitis pediatric outpatients

  7. Treatment effects of Tanreqing injection for acute bronchitis complicated by fever%痰热清注射液对急性支气管炎伴发热的治疗效果

    Institute of Scientific and Technical Information of China (English)

    李红燕

    2014-01-01

    Objective To investigate the application effects of Tanreqing injection for acute bronchitis complicated by fever.MethodsEighty-six patients with acute bronchitis complicated by fever admitted to our hospital from January 2012 to December 2013 were selected and divided into the control group and the observation group according to the treatment scheme. The control group received azithromycin treatment and the observation group received Tanreqing injection on the basis of the control group. The total effective rates, the disappearance time of patients' symptoms and sings and the adverse reactions during treatment of the two groups were compared. After 3 to 6 months of follow-up visits, the recurrence situation was observed.Results The total effective rate of the 43 patients of the observation group was 93.02% (40/43), which was significantly higher than that of the control group. The observation group had significantly shorter fever, cough and asthma, lung most rale disappearance and chest image recovery time than the control group. During treatment,the incidence of adverse reactions of the observation group was 2.33% (1/43), which was significantly lower than that of the control group. ConclusionIn the treatment of acute bronchitis complicated by fever, the application of Yanreqing injection can effectively improve the treatment effects, and reduce the incidence and recurrence of adverse reactions, thereby worthy of clinical promotion and application.%目的:探讨痰热清注射液在急性支气管炎伴发热中的应用效果。方法我院2012年1月~2013年12月间收治的急性支气管炎伴发热患者86例,按照治疗方案分为对照组和观察组,对照组患者给予阿奇霉素治疗,观察组在对照组基础上给予痰热清注射液,比较两组治疗总有效率、患者症状体征消失时间及治疗过程中不良反应;随访3~6个月,观察复发情况。结果观察组43例患者治疗总有效率达到93.02%(40/43

  8. 痰热清注射液规范治疗小儿急性支气管炎的效果观察%Effect observation of Tanreqing injection in the standardized treatment of acute bronchitis in children

    Institute of Scientific and Technical Information of China (English)

    刘喜梅

    2014-01-01

    目的:探讨痰热清注射液规范治疗小儿急性支气管炎的效果。方法选择本院儿科2012年1月~2013年1月收治的80例急性支气管炎患儿作为研究对象,根据随机数字表法将患者分为观察组和对照组,每组各40例。对照组给予止咳化痰、抗感染、抗病毒等常规综合方案治疗,观察组在此基础上加用痰热清注射液规范方案治疗,比较两组的临床效果。结果观察组的总有效率为97.5%,明显高于对照组的77.5%(P<0.05);观察组的退热时间、咳嗽明显减轻或消失时间均短于对照组(P<0.05)。结论在常规方案治疗的基础上,加用痰清热注射液规范治疗小儿急性支气管炎可显著提高临床效果,促使症状和体征消除,缩短病程,应用价值较为显著,对改善患儿预后,保障其身心健康有非常重要的意义。%Objective To explore the effect of Tanreqing injection in the standardized treatment of acute bronchitis in children. Methods 80 children with acute bronchitis who were admitted to the department of paediatrics in our hospital from January 2012 to January 2013 were selected as research subjects and they were divided into the observation group (n=40) and the control group (n=40) according to the random number table method.The regular and comprehensive treat-ment of relieving cough and reducing sputum,anti-infection and anti-virus were applied in the control group and a fur-ther standardized treatment of Tanreqing was added in the observation group on the basis of the control group,the clini-cal effect in the two groups was compared. Results The total effective rate in the observation group (97.5%) was signif-icantly higher than that of the control group (77.5%) (P<0.05);Fever abatement time and relieving or disappearing time of cough were both shorter than those in the control group (P<0.05). Conclusion On the basis of regular treatment,an additional standardized treatment of Tanreqing

  9. 喜炎平注射液治疗老年急性气管-支气管炎的临床研究%Clinical research on Xiyanping injection in treating elderly patients with acute airway-bronchitis

    Institute of Scientific and Technical Information of China (English)

    韩芳; 张伟东; 安学东

    2014-01-01

    OBJECTIVE To investigate the clinical results of Xiyanping injection in treating elderly patients with acute airway-bronchitis in order to improve the clinical diagnosis and treatment .METHODS Totally 70 elderly patients with acute airway-bronchitis from Feb .2010-Feb .2014 were selected and divided into two groups ,the control group of 35 patients treated with conventional symptomatic treatment ,and the observation group of 35 patients treated with addition of Xiyanping injection .The clinical effect was observed after treatment .RESULTS The effective rate and the total efficacy rate was 45 .72% and 82 .86% for the control group ,and was 62 .86% and 94 .29% for the observation group ,the difference was significant (P<0 .05) .The differences in lung function and blood gas analysis between the two groups before treatment were not significant but were significant after treatment (P< 0 .05) .The differences in improvement time for clinical manifestations were significant (P<0 .05) .CONCLUSION Xiyanping injection can improve clinical symptoms of patients with acute airway-bronchitis and shorten the course of treatment .%目的:探讨喜炎平注射液治疗老年急性气管-支气管炎临床效果,以期提高临床诊治水平。方法选取2010年2月-2014年2月70例老年急性气管-支气管炎患者为研究对象,将其分为对照组35例予常规对症治疗,观察组35例加用喜炎平注射液治疗,观察治疗后临床效果。结果对照组患者治疗显效及总有效率分别为45.72%、82.86%,观察组分别为62.86%、94.29%,两组比较差异有统计学意义( P<0.05);两组患者治疗前肺功能、血气分析比较,差异无统计学意义,而治疗后差异均有统计学意义(P<0.05);临床表现改善时间比较差异有统计学意义(P<0.05)。结论喜炎平注射液能改善急性气管-支气管炎患者临床症状,缩短疗程。

  10. 痰热清注射液治疗小儿急性支气管炎的临床疗效分析%Clinical efficacy analysis of Tanreqing injection for children acute bronchitis

    Institute of Scientific and Technical Information of China (English)

    张雷

    2011-01-01

    目的:探讨痰热清注射液治疗小儿急性支气管炎的临床效果.方法:将116例急性支气管炎随机分为治疗组和对照组各58例,对照组给予常规抗病毒、抗感染、止咳祛痰治疗,治疗组在对照组常规治疗的基础上加用痰热清注射液静脉滴注,剂量为0.5~1.0 ml/(kg·d),比较两组的治疗效果及症状改善情况.结果:治疗1周后,治疗组总有效率为96.55%(56/58),对照组总有效率为77.59%(45/58),两组疗效比较,差异有统计学意义(P<0.05);治疗组平均退热时间、咳嗽消失或明显减轻时间均短于对照组,差异有显著性(P<0.05).结论:在常规治疗的基础上应用痰热清注射液治疗小儿急性支气管炎能迅速缓解症状,缩短疗程,取得较满意的疗效.%Objective: To investigate the clinical efficacy of Tanreqing injection in the treatment of children acute bronchitis. Methods:116 patients with acute bronchitis were randomly divided into control group and treatment group, each 58 cases, the control group was given conventional antivirus, anti-infection, anti-cough expectoranting treatment, the treatment group added Tanreqing injection intravenous drip based on the control group of conventional treatment, dose for 0.5-1.0 ml/(kg·d), therapeutic effect and improvement of symptoms of two groups were compared. Results: After one week's treatment, the total effective rate of the treatment group was 96.55% (56/58), and the control group was 77.59% (45/58), compared with curative effect of the two groups, the difference had statistics significance (P<0.05). The average antifebrile time, cough disappeared or significantly reduced time of the treatment group were shorter than those of control group, there was a significant difference (P<0.05). Conclusion: the conventional treatment added Tanreqing injection in the treatment of children acute bronchitis can rapidly relieve symptoms, shorten the course of treatment, and achieve satisfactory

  11. Chinese medicine acupuncture hot Um package I, ironing acute airway-bronchitis clinical observation%中药热奄包I号穴位熨烫治疗急性气管--支气管炎的临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    王英; 杨忆; 康跃; 秦兰; 向平; 雷菲; 蒋波涛

    2015-01-01

    Objective: To investigate the thermal castrate package I, Chinese acupuncture treatment of acute airway ironing -bronchitis clinical efficacy and safety. Methods:The hospital from February 2011 to July 2013, 63 cases of acute treatment of acute airway-bronchitis were randomLy divided into traditional Chinese medicine acupuncture hot ironing Amami package I, the treatment group and the control group, the treatment group in the conventional Western medical treatment under Canadian Om package with herbal hot points I ironing treatment, the control of its clinical efficacy, assess their safety. Results: The treatment group and control group of acute acute airway-bronchitis clinical efficacy and symptom score compared to no change in two significant differences (P>0.05), in patients with cough relief time than the control group (P0.05),在患者咳嗽症状缓解时间优于对照组(P<0.05)。治疗组中药热奄包I号穴位熨烫治疗急性气管-支气管炎未见明显不良反应。结论:中药热奄包I号穴位熨烫治疗急性气管-支气管炎安全有效,可作为安全有效的中医治疗特色疗法在临床上进一步推广使用。

  12. Efifcacy of Fuganlin oral liquid for the treatment of 58 cases of children with capillary bronchitis%馥感啉口服液治疗小儿毛细支气管炎58例

    Institute of Scientific and Technical Information of China (English)

    朱一冰; 秦晔; 严竹君; 陈逸

    2015-01-01

    目的:观察馥感啉口服液治疗小儿毛细支气管炎的疗效。方法:选取毛细支气管炎患儿112例随机分为观察组58例和对照组54例。所有患者给予抗病毒、抗感染、雾化平喘等治疗,观察组在此基础上加用馥感啉口服液治疗,比较两组疗效。结果:观察组咳嗽消失、喘憋缓解、肺部湿啰音消失、肺部哮鸣音消失的时间均短于对照组(P<0.05),治疗有效率高于对照组(P<0.05)。两组患儿在治疗期间均无明显不良反应发生。结论:馥感啉口服液治疗小儿毛细支气管炎疗效显著,安全性好。%Objective:To observe the efficacy of Fuganlin oral liquid for the treatment of children with capillary bronchitis.Methods:One hundred and twelve cases of pediatric patients were randomly divided into an observation group (n=58) and a control group (n=54). All the patients were given anti-virus, anti-infection, atomizing asthma treatment, and meanwhile, the observation group was additionally given Fuganlin oral liquid treatment. The curative effects were compared between the two groups.Results:The time for the disappearance of the cough and the moist rale and wheezing sound of the lung and the asthma suppression mitigation was shorter in the observation group than in the control group (P<0.05). The treatment effective rate of the observation group was higher than that of the control group (P<0.05). There were no obvious adverse reactions in two groups during the treatment.Conclusion:Fuganlin oral liquid has obvious efifcacy on children capillary bronchitis with good safety.

  13. Molecular epidemiology of the avian infectious bronchitis virus basing on S1 glycoprotein%基于S1蛋白的禽传染性支气管炎病毒的分子流行病学研究

    Institute of Scientific and Technical Information of China (English)

    姜明国; 杨立芳

    2005-01-01

    Avian infectious bronchitis virus, a kind of ssRNA positive- strand virus which belongs to Coronaviridae without any DNA stage, is one of the most severe pathogenic agent causing acute, highly contagious respiratory and urogenital disease characterized by high mortality rate in affected avian flocks, resulting in gigantic economic loss every year. Thereby, it is urgent and necessary for us to research the molecular epidemiology of avian infectious bronchitis virus, and even develop vaccines basing above basic research results. Here we report the molecular evolution and genetic variation of the avian infectious bronchitis virus basing the conserved nucleotide acid sequence of S1gene encoding the spiker glycoprotein with the strong feature ofthe antigen immunity, locating on the surface of the avian infectious bronchitis virus particle, and provide the feasible strategy to develop the avian vaccine for effectively perturbing the infection of avian infectious bronchitis virus.%禽传染性支气管炎病毒是归属于冠状病毒属的没有DNA阶段的正义单链RNA病毒,以极高的死亡率引起禽呼吸泌尿性疾病的广泛流行,每年都给家禽饲养业造成巨大的经济损失.因此开展禽传染性支气管炎病毒的分子流行病学的研究并开发出相关的疫苗时下就显得迫切而且必要.现在,我们基于序列保守且具有强免疫原性的禽传染性支气管炎病毒粒子外壳剌突S1糖蛋白开展了分子流行病学研究,并提出了用于阻断禽传染性支气管炎病毒侵染的疫苗的可行性开发策略.

  14. 老年慢性支气管炎患者负性情绪及自尊感临床现状分析%Clinical analysis of negative emotions and self-esteem of elderly patients with chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    侯莉; 李家容; 王颖琦; 王玉兰

    2011-01-01

    目的:探讨老年慢性支气管炎患者负性情绪及自尊感的临床现状.方法:分别选取110例老年慢性支气管炎、110例慢性支气管炎非老年成人患者、110例正常体检健康成人依次设为观察组、对照组、正常对照组,均应用焦虑自评量表、Avillo的情绪情感形容词量表及Rosenberg自尊量表调查、比较其相关评分,比较不同临床特征观察组患者评分的差别.结果:观察组患者焦虑评分高于对照组、正常对照组(P<0.01),而情绪情感及自尊评分低于对照组、正常对照组(P<0.05,P<0.01);观察组患者焦虑、情绪情感及自尊评分与性别、婚姻状况、子女状况、经济收入密切相关(P<0.05);观察组患者焦虑与情绪情感评分具有负相关性(P<0.05),焦虑与自尊评分具有负相关性(P<0.01),情绪情感评分与自尊评分具有正相关性(P<0.05).结论:老年慢性支气管炎患者表现为明显的焦虑情绪、情绪情感水平下降、自尊感下降,尤其是女性、无配偶、子女不在身边及经济收入低的患者表现更明显,在临床中可针对此特点进行相关护理,从根源上提高其心理水平.%Objective: To analyze the clinical situation of negative emotions and self - esteem of elderly patients with chronic bronchitis. Methods: 110 elderly patients with chronic bronchitis, 110 non - elderly adult patients with chronic bronchitis and 110 healthy adults with routine physical examination were respectively selected and taken as the observation group, control group and normal control group. The anxiety self - rating scale, Avillo emotional adjective scale and Rosenberg self - esteem scale were used to conduct a survey and compare the scores and the different clinical features among the patients. Results: The anxiety scores were higher in the observation group than the control and normal control groups ( P <0. 01 ); emotion and self - esteem scores were lower in the observation

  15. Production of monoclonal antibodies against conserved components of infectious bronchitis virus Produção de anticorpos monoclonais contra componentes do vírus da bronquite infecciosa das aves

    Directory of Open Access Journals (Sweden)

    C.M. Souza

    2001-10-01

    Full Text Available Murine hybridomas producing IgG1 monoclonal antibodies (Mabs against N and S2 proteins (53KDa and 82KDa, respectively from avian infection bronchitis virus (IBV strain M41 were generated by the fusion of a myeloma cell line (Sp2/0-Ag14 with spleen cells from Balb/c mice previously immunized with whole virus IBV M41. Post-fusion screening criterion was by ELISA and 36 positive hybrids were generated after fusions. Two hybrids specific to N (N3F10 and S2 (S12B2 proteins from M41 (serotype Massachusetts were selected by western blotting. These Mabs recognized the Ark-99 (serotype Arkansas and A5968 (serotype Connecticut IBV strains in addition to M41. By ELISA, the Mab against the S2 (S12B2 recognized all reference and Brazilian strains (M41, SE-17, H52, 297, 283, PM-1, PM-2, PM-3, 351, 29-78 E 327 studied, while the Mab against N recognized only six (M41, SE-17, H52, 283, 327 e 297 strains. The Mab against S2 may become a useful tool for IBV detection on the routine diagnosis of infectious bronchitis, especially for helping the differential diagnosis of clinically and pathologically confusing diseases, while the Mab against N (N3F10 recognized a probably less conserved region among the strains and may be interesting to comparing IBV isolates.Foram produzidos anticorpos monoclonais (AcM da subclasse IgG1 contra as proteínas N (53KDa e S2 (82KDa do vírus da bronquite infecciosa das galinhas (VBIG amostra M41. Os híbridos secretores originaram-se da fusão entre células de mielomas da linhagem Sp2/0-Ag14 e linfócitos B de camundongos Balb/c previamente imunizados com o vírus completo. O primeiro critério de seleção foi por ELISA, no qual 36 híbridos originados de duas fusões reagiram positivamente; destes, foram selecionados dois AcM que reagiram contra as proteínas N (N3D4 e S2 (S12B2 do VBIG da amostra M41 (sorotipo Massachusetts no western blotting. Os mesmos AcM foram também capazes de reconhecer as estirpes Ark-99 (sorotipo Arkansas

  16. Primary diagnosis and therapy tests of nephropathogenic avian infectious bronchitis%鸡肾型传染性支气管炎的初步诊断与治疗

    Institute of Scientific and Technical Information of China (English)

    李瑞明; 史玉静; 韩涛; 韩忠燕; 宋小白

    2011-01-01

    [Objective ]The present study was conducted to investigate the epidemiology of avian infectious bronchitis (IB) in Qinhuangdao city of Hebei province, and to isolate the local representative strain of IB virus for development of immuo-vaccine. [Method]The epidemiology investigation, clinical manifestations and pathological changes in IB were recorded. The liver and kidney suspension of freshly sampled chicken were inoculated to ten--day SPF chick embryo allantoic cavity and the chicken embryo allantois solution was collected to conduct agar diffuse, haemagglutination (HA) and animal test. The comprehensive therapy was also practiced. [ Result ]The kidney of inoculated chick showed swelling and was found pale colored. White urate deposition in ureter was observed. The agar diffuse test result of allantois liquid showed positive results, as well as the HA and animal test results revealed that the isolated strain was IB virus. Based on pathological diagnosis, the lB was identified as nephropathgenic lB. The inactivated vaccine was made with isolated strains of nephropathogenic infectious bronchitis viruses. After 5 days of treatment with Hukang, Shenzhishuang, Hushentong and other medicines, the mortality of diseased chicken was recorded from 0.4 to 1.0%, the symptom in respiratory tract of chicken population decreased and the eggs production increased. The curative rate of lB in chicken reached 92.4%. [Conclustion ]The results of present study confirmed the disease as nephropathgenic lB. The proper medication and and immunization according to the virus strain can prevent the disease.%[目的]研究河北秦皇岛地区的鸡肾型鸡传染性支气管炎(IB)流行病学、分离鉴定地方代表毒株,为有效防制当地鸡肾型IB及研制具有免疫针对性的疫苗制剂提供参考依据.[方法]通过流行病学调查、临床症状、病理变化观察,取新鲜病死雏鸡肝脏、肾脏组织悬浮液接种10日龄SPF鸡胚尿囊腔,收集鸡胚尿

  17. A clinical study on treatment of acute exacerbations of chronic bronchitis with Sangpa Zhike decoction%桑杷止咳汤治疗慢性支气管炎急性发作的临床研究

    Institute of Scientific and Technical Information of China (English)

    严兴海; 蔡基鸿; 游方; 张蕾; 吕翠芬; 徐姗姗; 潘慧娟

    2014-01-01

    目的:观察桑杷止咳汤治疗慢性支气管炎急性发作的临床效果。方法选择2012年8月至2013年8月在新疆昌吉回族自治州中医医院门诊就诊的慢性支气管炎急性发作患者180例,按随机数字表法将患者分为桑杷止咳汤治疗组和西医治疗对照组,每组90例。两组均给予一般治疗,桑杷止咳汤治疗组在一般治疗的基础上加服桑杷止咳汤(组成:桑白皮10 g,枇杷叶10 g,鱼腥草10 g,蜜紫菀15 g,蜜款冬花6 g,浙贝母12 g,苏子10 g,白芥子6 g,桔梗10 g,白前12 g,陈皮6 g,百部6 g)每日1剂,水煎分2次服用;西医治疗对照组给予控制感染、止咳化痰等治疗方法,疗程均为7d。观察两组治疗前后中医证候疗效和咳嗽症状量化评分的变化。结果桑杷止咳汤治疗组治愈率明显高于西医治疗对照组〔70.00%(63/90)比33.33%(30/90),P<0.01〕。两组治疗前咳嗽症状量化评分比较差异无统计学意义,治疗后咳嗽症状量化积分均较治疗前明显降低,且以桑杷止咳汤治疗组降低更显著(分:1.66±1.12比4.36±2.32,P<0.01)。结论桑杷止咳汤治疗慢性支气管炎急性发作疗效显著。%Objective To observe the clinical effect of Sangpa Zhike decoction in the treatment of acute exacerbations of chronic bronchitis. Methods 180 patients with acute exacerbation of chronic bronchitis admitted to Autonomous Prefecture Hospital of traditional Chinese medicine(TCM)in Changji,Xinjiang,from August 2012 to August 2013 were enrolled. They were divided into Sangpa Zhike decoction treatment group and western medicine treatment control group by random number table,90 cases in each group. General treatments were given to the two groups. In the Sangpa Zhike decoction treatment group,additionally only oral Sangpa Zhike decoction was given(composition:Morus alba 10 g,loquat leaf 10 g,Houttuynia 10 g,honey aster 15 g,honey coltsfoot flower

  18. 慢性阻塞性肺疾病与急性支气管炎肺功能的对比研究%The comparable study of lung function between patients with chronic obstructive pulmonary disease and patients with acute bronchitis

    Institute of Scientific and Technical Information of China (English)

    叶江枫; 袁名辉; 蒙育林

    2014-01-01

    目的:探讨脉冲振荡法(IOS)在慢性阻塞性肺疾病(COPD)、急性支气管炎的检测意义。方法选择100例COPD患者、100例急性支气管炎患者与正常对照者100例行常规肺通气功能及IOS检测。观察VC、FVC、FEV1%、FEV1/FVC、MMEF、VMAX、MVV;Fres、Zrs、R5、R20、R35、X5、Rc、Rp。结果 COPD组与正常组比较,VC、FVC、FEV1%、FEV1/FVC、MMEF、VMAX、MVV明显降低,P<0.05;Zrs、Fres、R5、R35、X5、R20、Rp明显升高,P<0.05。急性支气管炎组与正常组比较,VC、FVC、FEV1%、MVV明显降低,P<0.05;Zrs、Fres、R5、R20、R35、X5、Rp明显升高,P<0.01。COPD组与急性支气管炎组比较,VC、FVC、FEV1%、FEV1/FVC、MMEF、VMAX明显降低,P<0.01;Zrs、Fres、R5、R20、R35、X5、Rp明显升高,P<0.01。结论 COPD存在阻塞性和限制性通气功能障碍,急性支气管炎存在限制性通气功能障碍;COPD、急性支气管炎均存在总气道阻力、周边气道阻力、周边弹性阻力异常升高。COPD气道阻力升高更明显。%Objective To explore the clinical application value of impulse oscillometry (IOS) in patients with chronic obstructive pulmonary disease (COPD) and acute bronchitis. Methods To compare the parameters of pulmonary ventilation function with the results of respiratory impedance measured by impulse oscillometry in 100 patients with COPD group, 100 patients with acute bronchitis and 100 healthy adults.To observe VC, FVC, FEV1%, FEV1/FVC, MMEF, VMAX, MVV, Fres, Zrs, R5, R20, R35, X5, Rc, Rp. Results There were significant decrease in VC, FVC, FEV1%, FEV1/FVC, VMAX, MVV, P<0.05. There were significant rise in Zrs, Fres, R5, R35、X5, R20, Rp, P<0.05 in COPD group compared with normal group. There were decrease in VC, FVC, FEV1%, MVV, P<0.05;there were significant rise in Zrs, Fres, R5, R20, R35, X5, Rp, P<0.01 in acute bronchitis group compared with normal group. There were significant decrease in VC, FVC

  19. 小儿支气管炎急性发作应用阿奇霉素的临床治疗效果观察%Observation on the Clinical Effect of Azithromycin in the Treatment of Children With Acute Bronchitis

    Institute of Scientific and Technical Information of China (English)

    李海涛

    2015-01-01

    目的:分析研究小儿支气管炎急性发作通过阿奇霉素进行治疗的方法以及治疗效果,为临床提供依据。方法选取2013年3月~2014年3月小儿支气管炎急性发作患者资料88例实施回顾性分析。结果观察组患者治疗效果高于对照组患者,不良反应发生几率低于对照组患者(P <0.05),具有统计学意义。结论针对小儿支气管炎急性发作通过阿奇霉素进行治疗效果明显,患者出现不良反应几率小,属于一类安全有效的抗菌药物。%Objective To analyze and study the methods and therapeutic effect of the treatment of acute bronchitis acute attack of children, and provide the basis for clinical treatment. Methods A retrospective analysis was carried out on 88 cases of acute exacerbation of children's bronchitis from March 2013 to March 2014. Results The therapeutic effect of the observation group was significantly higher than that of the control group, the incidence of adverse reactions was significantly lower than that of the control group (P < 0.05), with statistical significance. Conclusion In the treatment of children with acute bronchitis acute attack by the effect of treatment, patients with small adverse reactions, is a kind of safe and effective antibacterial drugs.

  20. Efficacy and Safety of Pharmacokinetically Enhanced Amoxicillin-Clavulanate at 2,000/125 Milligrams Twice Daily for 5 Days versus Amoxicillin-Clavulanate at 875/125 Milligrams Twice Daily for 7 Days in the Treatment of Acute Exacerbations of Chronic Bronchitis

    OpenAIRE

    Sethi, Sanjay; Breton, John; Wynne, Brian

    2005-01-01

    This randomized, controlled trial was designed to show that a short, 5-day course of pharmacokinetically enhanced amoxicillin-clavulanate at 2,000/125 mg (Augmentin XR) is as effective clinically as a longer, 7-day course of conventional amoxicillin-clavulanate at 875/125 mg (both given twice daily) in the treatment of acute exacerbations of chronic bronchitis (AECB). Amoxicillin-clavulanate at 2,000/125 mg was designed to extend the therapeutic levels of amoxicillin in serum over the 12-h do...

  1. 三拗片治疗急、慢性支气管炎风寒袭肺证80例分析%Treatment of acute and chronic bronchitis with syndrome of wind- cold attacking lung with San'ao tablets: An analysis of 80 cases

    Institute of Scientific and Technical Information of China (English)

    陈麒; 张炜; 张学超

    2012-01-01

    Objective To observe the clinical effect of treatment of acute and chronic bronchitis in acute stage with syndrome of wind - cold attacking lung with San'ao tablets. Methods Eighty cases of acute and chronic bronchitis in acute stage with syndrome of wind - cold attacking lung were treated with San'ao tablets for 7 days. The changes of clinical symptoms such as cough, sputum, wheeze were observed on the first day, the fifth and the seventh day. Results The total efficacy rate of San'ao tablets for treating acute and chronic bronchitis in acute stage with syndrome of wind-cold attacking lung was 93.75% . The main symptoms such as cough, expectoration and wheeze were significantly relieved. Conclusion San'ao tablets have an obvious clinical effect on a-cute and chronic bronchitis in acute stage with syndrome of wind- cold attacking King.%目的 观察三拗片治疗急性支气管炎和慢性支气管炎急性发作期风寒袭肺证的临床疗效.方法 将80例急性支气管炎和慢性支气管炎急性发作期风寒袭肺证患者给予三拗片治疗7d,观察患者治疗当日、第5天与第7天临床症状咳、痰、喘的变化.结果 三拗片对急、慢性支气管炎急性发作期风寒袭肺证患者的总有效率为93.75%,对主症咳嗽、咳痰和喘息具有明显改善作用.结论 三拗片可改善急性支气管炎和慢性支气管炎急性发作期风寒袭肺证患者的临床症.

  2. 中药防治鸡传染性支气管炎存在的问题及对策%Problems in Prevention and Treatment of Infectious Bronchitis with Traditional Chinese Medicine and the Counter Measures

    Institute of Scientific and Technical Information of China (English)

    王玲; 陈炅然; 郭天芬; 李宏胜; 杨峰; 胡广胜; 周绪正; 牛建荣

    2012-01-01

      The infectious bronchitis(IB)vaccines lack of cross immunity or have no cross immunity,and there is no specific drug for IB cases. Some traditional Chinese medicine(TCM)has virucidal effect,can adjust the immune function,has nonspecific antiviral function,and has good results and unique advantages compared with Western medicine in clinical prevention and treatment of IB. This paper is focused on the problems in research and development of TCM to control IB and discuss the research thinking and way,and suggests that the simple clinical validation for draft prescription should be avoided,the pharmacodynamics,pharmacology, pharmacokinetics,toxicology,TCM chemistry and mechanism should be studied in-depth way,and it is necessary to have strict scientific test design and test data,in order to further improve and expand the application of TCM in the prevention and treatment on livestock and poultry infectious diseases.%  鸡传染性支气管炎(IB)疫苗缺乏交叉免疫或完全无交叉免疫,发病后无特效药物治疗。有些中药具有抑杀病毒的作用,且能调节机体的免疫功能,具有非特异性的抗病毒功能,用于鸡IB的临床防治收效甚好,所用方剂与西药相比具有独特的优势。本文针对研发防治鸡传支中药存在的主要问题,探讨了研究的思路和途径,应避免仅对草拟方剂做简单的临床验证,需要对中药方剂的药效学、药理学、药代动力学、毒理学、中药化学及作用机理做深入研究,以及科学严谨的试验设计支持,大量试验数据证明,以期进一步完善并扩大中药在防治畜禽传染性疾病上的应用。

  3. Efecto del tiempo de exposición a PM10 en las urgencias por bronquitis aguda Effect of exposure time to PM10 on emergency admissions for acute bronchitis

    Directory of Open Access Journals (Sweden)

    Franz Muñoz

    2009-03-01

    Full Text Available Este trabajo analiza el efecto de las horas de exposición a PM10 en las urgencias diarias por bronquitis aguda, controlando por temperatura y humedad. El estudio fue realizado en seis sectores de la ciudad de Santiago, Chile, durante el período de invierno de los años 2002 al 2004, para lactantes ( 65 años. Analizamos el retraso de la respuesta mediante una función polinomial distributiva (pdl, incluida en un modelo lineal generalizado (GLM-pdl, y la estructura del efecto de la exposición, mediante modelos aditivos generalizados (GAM, utilizando regresión spline como técnica de estimación. Los resultados mostraron que al cuarto día de retardo, el efecto de la exposición fue mayor, especialmente en lactantes, y varió en la medida que incrementó la concentración atmosférica de PM10. El efecto de las horas de exposición a PM10 mostró una variación significativa, según el sector geográfico. Al estimar linealmente este efecto en el sector Oeste, notamos que el incremento de consultas diarias en lactantes fue de 3% por cada hora de exposición sobre os 150µg/m³.To study the health effect of air pollution, measured as particulate matter greater than 10mm in diameter (PM10, we analyzed the effect of daily hours of exposure on the number of urgency admissions for acute bronchitis, adjusting for temperature and humidity on the same day. The study was conducted in six regions of Santiago, Chile, during the winter of years 2002 to 2004, for infants and elders. The delay between pollution time series and disease was modeled using a polynomial distributed lag (PDL function included in a generalized linear model. The linearity assumption was evaluated using a smooth-spline model approach. The highest effect for exposure to PM10 was detected with 4 days of delay. For both groups, the effect of temperature was linear, but that of humidity was not. Air pollution effect varied according to level of exposure and geographic region, increasing

  4. Does a 10-valent pneumococcal-Haemophilus influenzae protein D conjugate vaccine prevent respiratory exacerbations in children with recurrent protracted bacterial bronchitis, chronic suppurative lung disease and bronchiectasis: protocol for a randomised controlled trial

    Science.gov (United States)

    2013-01-01

    Background Recurrent protracted bacterial bronchitis (PBB), chronic suppurative lung disease (CSLD) and bronchiectasis are characterised by a chronic wet cough and are important causes of childhood respiratory morbidity globally. Haemophilus influenzae and Streptococcus pneumoniae are the most commonly associated pathogens. As respiratory exacerbations impair quality of life and may be associated with disease progression, we will determine if the novel 10-valent pneumococcal-Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) reduces exacerbations in these children. Methods A multi-centre, parallel group, double-blind, randomised controlled trial in tertiary paediatric centres from three Australian cities is planned. Two hundred six children aged 18 months to 14 years with recurrent PBB, CSLD or bronchiectasis will be randomised to receive either two doses of PHiD-CV or control meningococcal (ACYW135) conjugate vaccine 2 months apart and followed for 12 months after the second vaccine dose. Randomisation will be stratified by site, age (, nasopharyngeal and saliva swabs, and serum will be collected at baseline and at 2, 3, 8 and 14 months post-enrolment. Local and systemic reactions will be recorded on daily diaries for 7 and 30 days, respectively, following each vaccine dose and serious adverse events monitored throughout the trial. Fortnightly, parental contact will help record respiratory exacerbations. The primary outcome is the incidence of respiratory exacerbations in the 12 months following the second vaccine dose. Secondary outcomes include: nasopharyngeal carriage of H. influenzae and S. pneumoniae vaccine and vaccine- related serotypes; systemic and mucosal immune responses to H. influenzae proteins and S. pneumoniae vaccine and vaccine-related serotypes; impact upon lung function in children aged ≥6 years; and vaccine safety. Discussion As H. influenzae is the most common bacterial pathogen associated with these chronic respiratory diseases in

  5. Afinidades antigênicas de amostras de campo do vírus da bronquite infecciosa das galinhas com a amostra Massachusetts M41 Antigenic affinities of infectious bronchitis virus field isolates to Massachusetts M41 strain

    Directory of Open Access Journals (Sweden)

    M.B. Souza

    2001-04-01

    Full Text Available Com o objetivo de avaliar as afinidades antigênicas entre 14 amostras de vírus da bronquite infecciosa das galinhas (VBIG isoladas de casos clínicos ocorridos entre 1972 e 1989 no Estado de Minas Gerais, sua reatividade frente a dois anticorpos monoclonais (AcMs específicos contra a glicoproteína S1 do sorotipo Massachusetts de VBIG foi examinada em ELISA. As 14 amostras de campo estudadas foram agrupadas, de acordo com o relacionamento antigênico aos AcMs, em relacionadas (três amostras e não relacionadas (onze amostras à amostra M41 do sorotipo Massachusetts. As amostras de campo não reconhecidas, considerando a alta especificidade dos AcMs à amostra M41, compõem uma diversidade que pode variar de integrantes do sorotipo Massachusetts de origem vacinal a sorotipos heterólogos. Amostras com afinidade antigênica à M41 (208-1972, PM1-1987 e PM2-1987 foram detectadas, o que configura a preservação da amostra no campo, apesar da alta variabilidade da glicoproteína S1, já que foram isoladas de surtos de doença natural nas regiões de avicultura de Minas Gerais. A detecção de antígenos de alta variabilidade que caracterizam a amostra M41, apesar das pressões da imunidade dos plantéis e da mutabilidade, pode indicar que os antígenos de alta afinidade aos receptores celulares (best fit que atingiram alto estágio evolutivo podem estar sendo preservados.Aiming to the evaluation of antigenic relationships among isolates of infectious bronchitis virus (IBV through their reactivity against Massachusetts M41 S1 glycopolypeptide specific monoclonal antibodies (Mab an ELISA was developed. Fourteen IBV isolates obtained from field cases of disease, reported from 1972 to 1989 in Minas Gerais, Brazil, were examined. The IBV isolates could be grouped into related or not to M41, based on the reactivity to M41 S1 specific Mabs. The unrecognized field isolates conform a diversity of representatives, which may range from Massachusetts

  6. 慢性支气管炎急性发作采用阿奇霉素与左氧氟沙星门诊治疗的临床体会%Clinical Experience of Azithromycin and Levofloxacin in the Treatment of Acute Exacerbation of Chronic Bronchitis in Outpatient

    Institute of Scientific and Technical Information of China (English)

    杨鸿雁

    2014-01-01

    目的:研究慢性支气管炎急性发作采用阿奇霉素与左氧氟沙星门诊治疗的临床效果。方法选取68例患者将其分为治疗组和对照组,均34例,对比治疗效果。结果对比两组患者临床治疗总有效率和症状缓解时间,治疗组患者同对照组患者间具有明显差异性,P<0.05。结论阿奇霉素与左氧氟沙星对慢性支气管炎急性发作效果显著。%Objective The clinical effect of azithromycin and levofloxacin in the treatment of outpatients of acute exacerbations of chronic bronchitis. Methods 68 patients were divided into treatment group and control group were 34 cases, treatment effect, comparison. Results The clinical treatment of the two groups were compared and the total effective rate and the duration of remission, patients in the treatment group with the control has obvious differences between the groups with P<0.05. Conclusion Azithromycin and levofloxacin on acute attack of chronic bronchitis effect.

  7. Preventive and Curative Effects of Card Shu Ning Combined with Influenza Vaccine on Senile Chronic Bronchitis Complicated with Acute Infection%卡舒宁联合流感疫苗对老年性慢性支气管炎合并急性感染的防治效果

    Institute of Scientific and Technical Information of China (English)

    高忠翠; 李江涛; 展胜

    2011-01-01

    目的 观察卡舒宁联合流感疫苗对老年性慢性支气管炎合并急性感染的防治效果.方法 选择多年反复感染、咳嗽、咳痰、不同程度哮喘的老年慢性支气管炎患者138人,随机分为观察组73人,对照组65人.观察组接种流感疫苗后2周注射卡舒宁,每周2次,疗程3个月;对照组仅注射卡舒宁,方法 同观察组.1年后,对两组病例统一进行电话或人户随访,内容包括慢性支气管炎急性感染次数、急性感染时住院次数及急性感染时抗生素治疗疗程.结果 观察组患者慢性支气管炎急性感染次数和住院总次数明显减少,抗生素治疗疗程明显缩短,与对照组相比,差异均有统计学意义(P<0.01).结论 卡舒宁联合流感疫苗可明显提高老年性慢性支气管炎合并急性感染的防治效果.%Objective To observe the preventive and curative effects of Card Shu Ning combined with influenza vaccine on senile chronic bronchitis complicated with acute infection. Methods A total of 138 patients with senile chronic bronchitis complicated with cough, expectoration and asthma at various degrees, who were infected repeatedly during the past years, were divided into trial (73 cases) and control (65 cases) groups randomly. The patients in trial group were inoculated with influenza vaccine and injected with Card Shu Ning 2 weeks later, while those in control group were injected with Card Shu Ning alone, twice a week for 3 months. Telephone or in-home follow-up was performed on the patients one year later, including the times of acute infpction with chronic bronchitis, times of hospitalization due to acute infection and the course of treatment of acute infection with antibiotics. Results Compared with those in control group, the times of acute infection with chronic bronchitis and the times of hospitalization due to acute infection of patients in trial group decreased significantly, while the course of treatment with antibiotics was

  8. Curative effect observation on atomization inhalation budesonide combined with bronchodilator therapy in the treatment of capillary bronchitis%雾化吸入布地奈德联合支气管扩张剂治疗毛细支气管炎的疗效观察

    Institute of Scientific and Technical Information of China (English)

    曾春英

    2014-01-01

    目的:探讨雾化吸入布地奈德联合支气管扩张剂治疗毛细支气管炎的安全性及有效性。方法将110例毛细支气管炎患儿随机分为观察组和对照组,每组55例,对照组患儿采用沙丁胺醇进行治疗,对观察组患儿采用沙丁胺醇联合布地奈德联合雾化吸入治疗,观察并比较两组患儿的临床疗效、临床症状、体征改善情况及药物不良反应。结果观察组的总有效率(90.9%)显著高于对照组(72.7%),观察组患儿喘憋、气促、咳嗽及肺部啰音消失时间均明显短于对照组(P<0.05);对照组有2例患儿心率加速,两组患儿均未发生严重不良反应。结论雾化吸入布地奈德联合支气管扩张剂治疗毛细支气管炎安全有效,可促进患儿恢复。%Objective To investigate safety and efficacy of atomization inhalation budesonide combined with bronchodilator in the treatment of capillary bronchitis. Methods From Apirl 2012 to June 2013, 110 cases of capillary bronchitis patients were randomly divided into observation group and control group, each group of 55 cases, control group were treated with salbutamol, observation group were treated with salbutamol and budesonide atomization inhalation therapy to observe and compare the clinical efficacy to improve clinical symptoms and signs and adverse drug reactions of two groups of children. Results The observation group total effective rate were(90.9%) significantly higher than the control group(72.7%), observation group recovery time of suppress, shortness of breath, cough and lung's significantly shorter than the control group, the differences were statistically significant(P<0.05), two groups of children were not happened serious adverse reaction. Conclusion Atomization inhalation budesonide combined with capillary in the treatment of capillary bronchitis is safe and effective, so it can promote children recovery.

  9. 异丙托溴铵、布地奈德雾化吸入加用口服急支糖浆辅助治疗小儿肺炎支原体肺炎的临床观察%Ipratropium Bromide Nebulized Budesonide Inhalation Plus Oral Acute Bronchitis Syrup Auxiliary Treatment of Mycoplasma Pneumoniae Pneumonia Clinical Observation

    Institute of Scientific and Technical Information of China (English)

    王丽珍; 李飞平; 罗芳; 张梅娟

    2012-01-01

    Objective; To study the budesonide, ipratropium bromide Stock aerosol inhalation plus oral acute bronchitis syrup efficacy of mycoplasma pneumonia in children. Method; from May 2011 to May 2012 in our hospital diagnosed with pneumonia, mycoplasma pneumonia, aged 3 to 14 years old, 69 cases of hospitalized children, 35 cases were randomly divided into a control group and a test group of 34 patients. Test group application budesonide, ipratropium bromide atomizing inhalation plus oral acute bronchitis syrup, observation and comparison of the two groups on the basis of given antibiotics. Experimental group, children with cough disappeared time, of pulmonary rales disappear and hospitalization time there was significantly shorter (P<0.01) than the control group, the total effective rate in the test group than the control group (P<0. 01). Conclusion:Budesonide, ipratropium bromide oxygen drive to the aerosol inhalation plus oral acute bronchitis syrup can be used as auxiliary treatment of mycoplasma pneumonia treatment.%目的:研究布地奈德、异丙托溴铵联合雾化吸入加用口服急支糖浆对小儿支原体肺炎的疗效.方法:将2011年5月-2012年5月在我院诊断为肺炎支原体肺炎,年龄3~14岁的69例住院患儿,随机分为对照组35例与试验组34例.在给予抗感染的基础上试验组应用布地奈德、异丙托溴铵氧气驱动雾化吸入加用口服急支糖浆,观察比较两组疗效.结果:试验组患儿咳嗽消失时间、肺部罗音消失时间及住院时间均比对照组有极显著缩短(P<0.01),试验组总有效率比对照组高(P<0.01).结论:布地奈德、异丙托溴铵氧气驱动雾化吸入加用口服急支糖浆可以作为治疗小儿支原体肺炎的辅助治疗方式.

  10. 应用雾化吸入利多卡因治疗慢性喘息型支气管炎急性发作的临床效果探讨%Application Clinical Effect on Atomizing Inhalation of Lidocaine for the Treatment of Chronic Wheezing Bronchitis Acute Episodes

    Institute of Scientific and Technical Information of China (English)

    芦万杰

    2015-01-01

    Objective To explore the clinical effect on atomization inhalation of lidocaine for the treatment of chronic wheezing bronchitis acute. Methods Selected 56 cases of chronic wheezing bronchitis acute episodes in our hospital as the observation group, patients with retrospective analysis of early departments of the clinical data of 55 patients with conditions similar to the control group. Control group patients received routine western medicine treatment, give atomization inhalation of lidocaine treatment group patients. To investigate the clinical therapeutic effect in both groups and contrast. Results Atomization inhalation of lidocaine treatment in the observation group of patients clinical treatment the total effective rate was 91.07%, significantly higher than the 78.18% of the control group treated with conventional treatment, compare the differences between groups,χ2=7.775, P<0.05,had statistically signiifcance. Conclusion The type of chronic wheezing bronchitis acute clinical treatment process, atomization inhalation of lidocaine therapy has good clinical effect, the recurrence rate is low.%目的:探讨雾化吸入利多卡因治疗慢性喘息型支气管炎急性发作的临床效果。方法选取在我院接诊的56例慢性喘息型支气管炎急性发作患者为观察组,回顾性分析早期我院接诊的55例条件相似的患者的临床资料,设为对照组。对照组患者接受常规西医治疗,给予观察组患者雾化吸入利多卡因治疗。对两组患者临床治疗效果进行调查和对比。结果接受雾化吸入利多卡因治疗的观察组患者临床治疗总有效率为91.07%,高于接受常规治疗的对照组患者的78.18%,χ2=7.775,P<0.05,差异具有统计学意义。结论在慢性喘息型支气管炎急性发作的临床治疗过程中,雾化吸入利多卡因治疗具有较好的临床效果,复发率较低。

  11. Observation of Reduning Injection for children with acute tracheitis-bronchitis complicated with fever%热毒宁注射液治疗急性气管和支气管炎伴发热患儿的临床观察

    Institute of Scientific and Technical Information of China (English)

    弓育梅

    2009-01-01

    Objective To observe the curative effect of Reduning on the children with the acute tracheitis-bronchitis complicated with fever. Methods One hundred acute tracheitis-bronchitis infants with fever during Janu-ary 2007 to January 2008 were divided into treatment group and control group by random number table with 50 cases in each group. All infants received routine treatment, and infants in treatment group got additional treatment of Re-duning Injection. Five to seven days were regarded as one course of treatment. The changes of clinical manifesta-tion, peripheral blood,hepatic function and renal function were observed. Results The cure rate was 96% and 70% in treatment group and control group respectively (P < 0.01 ). There was no adverse effect observed. Conclusion Reduning is effective and safe for children with the acute tracheitis-bronchitis complicated with fever.%目的 探讨热毒宁注射液对急性气管/支气管炎伴发热患儿的疗效.方法 2007年1月至2008年1月在我院儿科门诊及住院用热毒宁注射液治疗100例急性气管/支气管炎伴发热患儿,按随机数字表法分为治疗组和对照组各50例.2组患儿均采用儿科常规综合性治疗,在此基础上,治疗组应用热毒宁注射液,剂量按1~5岁0.5~0.8 ml/(kg·d),5~10岁10 ml/次,1次/d,加入5%葡萄糖溶液或生理盐水中静脉滴注.5~7 d为1个疗程.观察治疗前后症状体征的变化以及外周血、肝功能、肾功能变化.结果 治疗组治愈率为96%(48/50),对照组为60%(30/50),2组相比差异有统计学意义(P<0.01),且治疗组无一例发生不良反应.结论 热毒宁注射液对急性气管/支气管炎伴发热患儿的疗效较好,安全性较高.

  12. 沐舒坦雾化吸入治疗老年慢性支气管炎急性发作临床观察%Clinical observation of mucosolvan atomizing inhalation in the treatment of acute exacerbations of chronic bronchitis in eldly patients

    Institute of Scientific and Technical Information of China (English)

    孟蕾; 朱剑

    2015-01-01

    目的:观察沐舒坦雾化吸入治疗老年慢性支气管炎急性发作患者的临床疗效。方法:收治老年慢性支气管炎急性发作患者106例,分为雾化吸入组和静脉滴注组,雾化吸入组给予沐舒坦雾化吸入治疗,静脉滴注组给予沐舒坦静脉滴注治疗,比较两组疗效。结果:雾化吸入组的临床治疗总有效率明显高于静脉滴注组,咳嗽缓解时间、喘息缓解时间明显早于静脉滴注组,住院时间明显短于静脉滴注组(P<0.05)。结论:沐舒坦雾化吸入治疗老年慢性支气管炎急性发作患者起效更快,临床治疗效果更确切。%Objective:To explore the clinical effect of mucosolvan aerosol inhalation in the treatment of acute exacerbations of chronic bronchitis in eldly patients.Methods:106 elderly patients with acute exacerbation of chronic bronchitis patients were selected.They were divided into the atomizing inhalation group and intravenous infusion group.The atomizing inhalation group was given mucosolvan aerosol inhalation.The intravenous infusion group was given ambroxol intravenous drip treatment.We compared the efficacy of two groups.Results:In the atomizing inhalation group,the total efficiency of clinical treatment was significantly higher than that of intravenous infusion group;the remission time of cough,the remission time of breathing were significantly earlier than the intravenous infusion group;the hospitalization time was significantly shorter than the intravenous infusion group(P<0.05).Conclusion:The onset of mucosolvan aerosol inhalation in the treatment of acute exacerbations of chronic bronchitis in eldly patients was faster.Clinical therapeutic effect was more precise.

  13. Clinical Observation on Effect of Etimicin Sulfate Plus Cefmetazole Sodium on Acute Attack of Chronic Bronchitis%硫酸依替米星联合头孢美唑钠治疗慢性支气管炎急性发作的临床观察

    Institute of Scientific and Technical Information of China (English)

    袁艺

    2015-01-01

    目的:观察硫酸依替米星联合头孢美唑钠治疗慢性支气管炎急性发作的疗效。方法:将100例慢性支气管炎急性发作的患者随机分成对照组和研究组,每组50例。对照组单纯给予头孢美唑钠治疗,研究组给予硫酸依替米星联合头孢美唑钠治疗,进行临床疗效观察。结果:研究组临床有效率为89.5%,而对照组临床有效率为50.5%,研究组有效率明显高于对照组,差异有统计学意义( P<0.05)。结论:硫酸依替米星联合头孢美唑钠可有效治疗慢性支气管炎急性发作。%Objective:To observation the effect of etimicin sulfate plus cefmetazole sodium on the onset of chronic bronchitis .Methods:Ramdomly divide 100 cases of patients who were attacked acutely by chronic bronchitis into control group and research group ,50 cases for each .Treat the control group with cefmetazole sodium while the research group were treated with etimicin sulfate plus cefmetazole sodium .Make observa‐tion on the clinical effect .Results:The clinical effective rate of the research group was 89 .5% while that of the control group was 50 .5% ,the effective rate of the research group was obviously higher than that of the control group ,the difference was statistically significant ( P < 0 .05 ) .Conclusion:Etimicin sulfate plus cefmetazole sodium can effectively treat the acute attack of chronic bronchitis .

  14. Suhuang Capsule on Acute Attack of Senile Chronic Bronchitis the Curative Effects of the Patients With Observation%苏黄止咳胶囊对老年慢性支气管炎急性发作期患者的疗效观察

    Institute of Scientific and Technical Information of China (English)

    胡秋月

    2015-01-01

    目的:探讨苏黄止咳胶囊治疗老年慢性支气管炎急性发作期的临床疗效。方法选取124例慢性支气管炎急性发作期老年患者为研究对象,将其随机分为对照组和治疗组各62例,对照组给予常规治疗,治疗组在常规治疗的基础上采用苏黄止咳胶囊治疗,对比分析两组的治疗效果。结果治疗组患者临床治疗效果显著高于对照组,差异具有统计学意义(χ2=6.317,P<0.05)。结论采用苏黄止咳胶囊治疗处于慢性支气管炎急性发作期的老年患者,安全性高,治疗效果好,值得临床推广使用。%ObjectiveTo investigate the clinical curative effect of Suhuangzhike capsule in the treatment of senile chronic bronchitis in acute attack period. MethodsSelected 124 cases of acute exacerbation of chronic bronchitis in senile patients as the research object, then they were randomly divided into control group and treatment group with 62 cases in each group, the control group was given conventional treatment, the treatment group used Suhuangzhike capsule treatment on the basis of conventional therapy, compared two groups of treatment effect.ResultsThe clinical effect of the treatment of the patients in the treatment group was significantly higher than the control group, with signiifcant difference (χ2=6.317,P<0.05).Conclusion The use of Suhuangzhike capsule in the treatment of elderly patients with chronic bronchitis in acute attack period, high security, good therapeutic effect, is worthy of clinical use.

  15. 112例误诊为支气管炎的老年慢性咳嗽病因分析%Etiological investigation of the 112 elderly patients with chronic cough misdiagnosed as bronchitis

    Institute of Scientific and Technical Information of China (English)

    林芳; 王浩彦

    2012-01-01

    目的 探讨老年患者慢性咳嗽的误诊及病因分布.方法 基层医院误诊为支气管炎的112例老年慢性咳嗽患者,采用咳嗽诊治指南制定的诊断程序,判断病因并予针对性治疗.结果 最终病因明确107例(95.54%),其中单一病因为89例(79.46%),复合病因为18例(16.07%).老年患者病因诊断前三位为胃食管返流性咳嗽、咳嗽变异型哮喘 、上气道咳嗽综合征,在女性患者和男性患者中分别占26.39%,20.83%,18.06%和29.31%,22.41%,18.97%.三者占慢性咳嗽病因的67.69%,其次是ACEI诱发的咳嗽.经特异性治疗后咳嗽明显减轻或消失为103例,有效率为91.96%,其余均为部分缓解.结论 老年慢性咳嗽病因复杂常被误诊,规范慢性咳嗽病因诊断程序对提高老年慢性咳嗽诊治水平有重要意义.%Objective The purpose of this study is to explore the etiology and misdiagnosis of the elderly patients with chronic cough. Methods A total of 112 the elderly patients ( 62 females, 50 males ) with chronic cough misdiagnosed as bronchitis by primary hospital were studied. Based on " Guideline on Diagnosis and Treatment of Chronic Cough" established by China Medical, the causes of chronic cough would be confirmed and given specific therapy. Results 107 of 112 patients( 95. 54% )were finally confirmed. Chronic cough due to a single cause was found in 89 patients ( 79. 46% ), and due to two causes in 18 patients ( 16. 07% ). The top three causes were gastroesophageal reflux cough ( GERC ), cough variant asthma ( CVA ), upper airway cough syndrome ( UACS ) and accounted for 67. 69% , followed by the ACEI-induced cough. The three causes accounted for 26. 39% , 20. 83% , 18. 06% in females and 29. 31% , 22. 41% , 18. 97% in male patients, respectively. After specific therapy based on diagnosis, cough cured and alleviated in 103 patients (91. 96% ); the rest are partially alleviated. Conclusions The cause of chronic cough in the elderly is complex and often

  16. SEROLOGIC DYNAMIC OF INFECTIO US BRONCHITIS VIRUS IN A BROILER FLOCK IN CUNDINAMARCA DINÁMICA SEROLÓGICA DEL VIRUS DE BRONQUITIS INFECCIOSA EN UNA GRANJA DE POLLO DE ENGORDE DEL DEPARTAMENTO DE CUNDINAMARCA

    Directory of Open Access Journals (Sweden)

    Vera Alfonso Victor Julio

    2009-04-01

    Full Text Available The infectious bronchitis virus (IBV causes a highly contagious disease, spread worldwide, leading to serious economic losses. Sometimes the disease is associated with other entities such as infectious bursal disease virus, Newcastle disease virus, Mycoplasma gallisepticum and Escherichia coli. The highly genetic variability of the virus has generated a large number of viral strains with different clinical presentations. The objective was to assess the dynamics of the virus antibodies in birds vaccinated and not vaccinated against IBV, hosted on a broiler farm where the agent was detected by RT-PCR in Fusagasuga, Colombia and vaccinated birds in semi-isolation conditions in Bogotá. To order this, 3 groups of birds (Ross 308 from 1 day of age (44 birds/group, which were vaccinated with a live attenuated virus strain Massachusetts H120, and the immune response was evaluated through the Elisa test. Since day 24 of age the birds showed a progressive decrease in antibody titers in all three groups, although in the vaccinated and unvaccinated birds kept at the farm were found higher levels of antibodies in the group of semi-isolation. Starting at day 28 in the birds housed in field, the antibodies titles rose slightly until the end of cycle. The slight increase in the level of antibodies may result from exposure to the virus vaccine generated a reversal of pathogenic viral persistence or a late exposure to field virus.El virus de bronquitis infecciosa (IBV causa una enfermedad altamente contagiosa, distribuida mundialmente, que conlleva graves pérdidas económicas. En algunas oportunidades se asocia con otras entidades como los virus de las enfermedades de Gumboro y de Newcastle, Mycoplasma gallisepticum y Escherichia coli. La alta variabilidad genética del virus ha generado una gran cantidad de cepas virales con diferentes cuadros clínicos. El objetivo del trabajo fue evaluar la dinámica de anticuerpos del IBV en aves vacunadas y no vacunadas

  17. Analysis of similarity of the SI gene in infectious bronchitis virus (IBV isolates in Shanghai, China Análisis de similaridad del gen S1 de aislados del virus de la bronquitis infecciosa (IBV en Shanghai, China

    Directory of Open Access Journals (Sweden)

    J G Zhu

    2007-01-01

    Full Text Available The aim of the study was to analyze the similarity of the SI gene in 5 novel viral strains of infectious bronchitis virus (IBV isolated in Shanghai, China, using a pair of specific primers which were designed based on the published sequences of the S gene of IBV. The 5 full-length cDNA segments of the SI gene were amplified from the 5 isolated strains with RT-PCR. It was confirmed that the nucleotide sequences of the SI gene in the 5 strains isolated from chickens and pigeon have a length of 1626 bp and encode 541 amino acid residues. Compared to the sequence of selected reference IBV strains published in GenBank, the 4 strains from chickens exhibited 77.4%-82.9% identity in the SI gene sequence, with the deduced similarity of the protein sequence being 74.7%-82.6%, while the strain from pigeon exhibited 79.3%-99.6% similarity in the SI gene sequence, with a deduced identity of the protein sequence of 81.6%-99.6%. The SI protein cleavage site sequence of these isolates contains 5 consecutive basic amino acids, named, Arg-Arg-Phe-Arg-Arg (RRFRR similar to most of IBV strains. The results indicated that the variability range of the SI gene structure is high, corresponding with the biological character of IBV, and that molecularly the five isolated strains from Shanghai have a close relationship with the IBV reference strains. It was concluded that the five isolated strains belong to IBV, even though one of them was isolated from pigeonsEl objetivo del estudio fue analizar la similaridad del gen SI de 5 nuevas cepas virales del virus de la bronquitis infecciosa (IBV aislado en Shangai, China, para lo cual se usaron un par de partidores específicos, los cuales fueron designados en base a las secuencias publicadas del gen S del IBV. Los 5 segmentos completos de cDNA del gen SI fueron amplificados de las 5 cepas aisladas con RT-PCR. Se pudo confirmar que las secuencias de nucleótidos de genes SI en las 5 cepas aisladas de gallinas y palomas tienen

  18. Isolation and biological properties of avian infectious bronchitis virus isolated from Shanxi province%鸡传染性支气管炎病毒地方流行株的分离与鉴定

    Institute of Scientific and Technical Information of China (English)

    闫芳; 化丽珍; 岳文斌; 刘娟; 李绪英; 赵宇军; 吉文汇; 刘风波; 吴倩; 任家琰

    2009-01-01

    从山西各地区疑似鸡传染性支气管炎(IB)的病料中,分离到5株鸡传染性支气管炎病毒(IBV)分离株,并对分离病毒进行了病毒形态观察、对鸡新城疫病毒(NDV)的干扰、鸡胚致病性试验、动物回归试验、血凝特性试验、病毒理化特性测定等生物特性鉴定及IBV N基因特异性片段的检测.电镜观察,可见直径为60~120 am,有囊膜及纤突呈冠状排列的病毒粒子;对NDV有明显的干扰作用;分离株的传代物均有明显的致鸡胚矮小化作用;动物回归感染死亡鸡肾脏病变明显,表现肾脏肿大、花斑肾现象,输尿管内充塞大量尿酸盐;无直接血凝性,经1%胰酶处理后可凝集鸡红细胞;分离株对乙醚和氯仿敏感;采用反转录-聚合酶链式反应(RT-PCR)对分离毒株进行扩增,结果均扩增出特异N基因核酸片段.%Five field strains of infectious bronchitis virus (IBV) were isolated from suspected flocks from different time and different regions of Shanxi province,respectively,and characterized by a series of systematic identification assays,such as morphological observation by electron-microscope,interfering with the propagation of NDV,virus pathological role to chicken embryo,virus pathological role to SPF chickens,hemagglutination activity,physiscochemical,and reverse transcription polymerase chain reaction(RT-PCR).The results showed:The typical coronavirus which the spherical virions 60-120 nm in diameter and surface covered with spike like corona were observed under electron-microscope)The propagation of NDV strain was seriously interfered by the 5 isolates respectively;The embryonated chicken egg passages of the 5 isolates could dwarf with chicken embryos;The five isolates had no hemagglutination activity,but after treatment with 1% trypsin,it can agglutinate chicken red blood cell.The strains are sensitive to chloroform and ethyl ether.The SPF chickens which inoculated with the 5 isolates showed clinical sign and

  19. 支气管哮喘和慢性喘息型支气管炎患者发作期呼吸音的分析研究%Spectral analysis of breath sounds in asthmatics and chronic asthmatic bronchitis during acute episode

    Institute of Scientific and Technical Information of China (English)

    辛晓峰; 殷凯生; 张希龙; 施毅; 黄小平

    2003-01-01

    Objectives:To evaluate and differentiate the spectral characteristics of the breath sounds in patients with asthmatics and chronic asthmatic bronchitis during episode. Methods:The breath sounds in 10 patients with asthmatics and 8 patients with chronic asthmatic bronchitis during episode were recorded by using microphone and computer and analyzed with FFT(fast-Fourier transform). Results: No difference of the expiratory frequency and intensity was found between the wheezes in patients with asthmatics[PF=(388.42±82.43)Hz, Q25%=(312.96±66.88)Hz,Q50%=(422.24±91.16)Hz,Q75%=(538.76±110.22)Hz, LSI=(23.21±0.82)dB,respectively],and chronic asthmatic bronchitis[PF=(359.43±45.46)Hz,Q25%=(296.98±67.84)Hz,Q50%=(421.43±91.82)Hz,Q75%=(523.287±60.16)Hz,LSI=(23.11±0.56)dB, respectively] during episode(P>0.05). However, during episode the inspiratory frequencies in patients with chronic asthmatic bronchitis[PF=(176.68 ±36.84)Hz,Q25%=(171.32±32.64)Hz,Q50%=(229.69±31.87)Hz,Q75%=(382.36±55.21)Hz, respectively] was significantly lower than that in asthmatics [PF=(354.21±67.58)Hz,Q25%=(286.42±53.68)Hz,Q50%=(386.77±74.18)Hz,Q75%=(554.68±84.72)Hz,respectively,P0.05);发作期慢喘支患者吸气时的频率比发作期哮喘患者低[两组的PF,Q25%,Q50%,Q75%分别为(176.68±36.84)Hz,(171.32±32.64)Hz,(229.69±31.87)Hz,(382.36±55.21)Hz和(354.21±67.58)Hz,(286.42±53.68)Hz,(386.77±74.18)Hz,(554.68±84.72)Hz,P<0.05或P<0.01]. 结论:哮喘和慢喘支患者发作期呼吸音的频谱分析,有助于发作期哮喘和发作期慢喘支的诊断和鉴别诊断.

  20. Clinical Effect of Atomization Inhalation of Lidocaine for Treatment of Acute Attack of Chronic Asthmatic Bronchitis%雾化吸入利多卡因治疗慢性喘息型支气管炎急性发作的临床疗效

    Institute of Scientific and Technical Information of China (English)

    张欢

    2015-01-01

    ObjectiveTo discuss and study the clinical effect and significance of atomization inhalation of lidocaine for treatment of acute attack of chronic asthmatic bronchitis.MethodRandomly selected patients in pediatric acute episode of chronic asthmatic bronchitis in 100 cases and divided into combination group and common group both with 50 cases. Common group was given routine treatment and combination group was given atomization inhalation of lidocaine on basis of routine treatment. After different treatments, total effective rate and blood gas analysis of the 2 groups were compared. ResultTotal effective rate of combination group was 100% obviously higher than common group 78%(P<0.05). Changes of blood gas analysis of combination group were obvious superior to common group (P<0.05).ConclusionAtomization inhalation of lidocaine for treatment of acute attack of chronic asthmatic bronchitis has signiifcant clinical effect. It can effectively restrain smooth muscle contraction, reduce bronchial hyperresponsiveness and obviously relieve breathing phenomenon of patients within a short time. Besides, it can also relieve edema and inlfammatory reaction, and effectively control acute attack of bronchitis.%目的:研究利多卡因雾化吸入用于治疗慢性喘息型支气管炎发作的临床疗效与意义。方法随机选取就诊于我院儿科慢性喘息型支气管炎急性发作患儿100例。分组为联合组、普通组,各50例。其中为普通组患者进行常规治疗;联合组给在常规治疗基础上联合雾化吸入利多卡因。比较两组患者经过不同治疗后总有效率、血气分析等指标。结果两组患者不同治疗后总有效率的比较,显示治疗后联合利多卡因雾化吸入患者总有效率为100%,显著优于常规治疗组78%(P<0.05),联合组治疗效果较好;治疗前后血气分析值比较显示联合组与普通组治疗前血气分析值无显著差异(P>0.05)。治疗后联合组血

  1. The clinical research on asarone injection in atomization adjuvant for the pediatric acute bronchitis for 180 cases%细辛脑注射液雾化辅助治疗小儿急性支气管炎180例疗效观察

    Institute of Scientific and Technical Information of China (English)

    袁杰; 胡以信; 卢玉蓉

    2014-01-01

    Objective:To investigate the clinical effect of asarone injection in atomization adjuvant for the pediatric acute bronchitis. Methods:One hundred and eighty children who were randomly to divide into two groups,the control group were trea-ted by ammonia bromine hydrochloride injection,the treatment group were treated by asarone injection. To observe the cough time,antifebrile time and wet rale disappearing time. Results:The time of the treatment group was shorter than the control group in the cough time,antifebrile time and wet rale disappearing time. Conclusion:The clinical curative effect for the asarone injec-tion in atomization adjuvant therapying the pediatric acute bronchitis,and it has less adverse reaction.%目的:探讨细辛脑注射液雾化辅助治疗小儿急性支气管炎的临床疗效。方法:将符合诊断的患儿180例随机分为两组,对照组采用盐酸氨溴索注射液治疗,治疗组采用细辛脑注射液治疗,观察两组止咳时间、退热时间及湿啰音消失时间。结果:治疗组止咳时间、退热时间及肺部啰音消失时间均明显短于对照组。结论:细辛脑注射液雾化辅助治疗小儿急性支气管炎临床疗效显著,不良反应小。

  2. Detection of soluble intercellular adhesion molecule-1 in serum of children with virus-associated wheezing bronchitis and correlation analysis with breathing-related risk factors%病毒相关性喘息性支气管炎患儿血清sICAM-1的检测及其与喘息高危因素的相关性分析

    Institute of Scientific and Technical Information of China (English)

    莫蔚农; 徐嘉望; 王红旗

    2012-01-01

    目的:探讨血清可溶性细胞间粘附分子-1(sICAM-1)在病毒相关性喘息性支气管炎发病中的作用,分析血清sICAM-1水平与喘息反复发作的高危因素者之间的关系.方法:采用酶联免疫吸附试验方法测定70例病毒相关性喘息性支气管炎急性期和恢复期以及30例健康儿童血清sICAM-1水平,分析病毒相关性喘息性支气管炎喘息反复发作的可能相关因素.结果:急性期血清sICAM-1水平高于恢复期和对照组,差异有统计学意义(P<0.05);恢复期血清sICAM-1水平与对照组比较差异无统计学意义(P>0.05).随访期内有23例患儿喘息反复发作,其血清sICAM-1水平为(218.94 ±60.82) ng/ml.有过敏性疾病史和遗传史患儿血清sICAM-1水平显著高于无过敏性疾病史和遗传史患儿,差异有统计学意义(P<0.05).结论:血清sICAM-1参与了病毒相关性喘息性支气管炎发生和发展以及喘息复发,有过敏性疾病和遗传史病毒感染所致的喘息性支气管炎患儿易喘息反复发作.%Objective: To explore the effect of serum soluble intercellular adhesion molecule — 1 ( sICAM - 1) in the occurrence of virus — associated wheezing bronchitis, and analyze the relationship between sICAM - 1 and high risk factors of repeated onset of wheezing. Methods: Enzyme -linked immunosorbent assay (ELISA) was used to detect the serum levels of sICAM - 1 in 70 children with virus — associated wheezing bronchitis at acute phase and recovery phase and 30 healthy children , the probable related factors of repeated onset of virus — associated wheezing bronchitis were analyzed. Results: The serum level of sICAM — 1 in children with virus — associated wheezing bronchitis at acute was significantly higher than those in case group at recovery phase and control group, there was statistically significant difference (P 0. 05) . During follow — up period, wheezing occurred repeatedly in 23 children, and the serum level of s

  3. 金草口服液治疗小儿急性支气管炎痰热壅肺证的多中心临床研究%Multi-center Clinical Study on Jincao Oral Liquid in the Treatment of Phlegm-heat Obstructing Lung Syndrome in Children with Acute Bronchitis

    Institute of Scientific and Technical Information of China (English)

    陈曦; 马融; 胡思源; 刘虹; 黄文玉; 李荣辉; 向希雄; 闫慧敏

    2013-01-01

    OBJECTIVE: To evaluate the effectiveness and safety of Jincao oral liquid in the treatment of phlegm-heat obstructing lung syndrome in children with acute bronchitis. METHODS: Stratified random, double-blind, parallel control of positive drug and multi-center clinical study were applied. Trial group and control group were given Jincao oral liquid and Jizhi syrup respectively, 5 ml per time for children aged 1-2 years old, 10 ml children aged 3-6 years old, 15 ml children aged 7-14 years old, 3 times a day for 5 days. RESULTS: The effectiveness of Jincao oral liquid for cough, expectoration and physical signs of phlegm-heat obstructing lung syndrome in children with acute bronchitis reached 87.20% , 81.71% , 80.37% (full data analysis set) respectively, which was similar to control group. Results of full data analysis set were in line with that of program data set. There was no significant difference between therapeutic efficacies of main symptoms and therapeutic efficacies of secondary symptoms, disease, syndrome and thoracic roentgenoscopy(P>0.05). No ADR related to drug use was found. CONCLUSION: Jincao oral liquid possesses obvious effectiveness for cough, expectoration and physical signs of mild and moderate pediatric acute bronchitis, which is similar to Jizhi syrup.%目的:评价金草口服液治疗小儿急性支气管炎痰热壅肺证的有效性与安全性.方法:采用分层区组随机、双盲、阳性药平行对照、多中心临床研究的方法.试验组与对照组患者分别服用金草口服液和急支糖浆,两药的用量均为1~2岁每次5 ml;3~6岁每次10 ml;7~14岁每次15 ml.每日3次,疗程均为5d.结果:金草口服液对轻、中度小儿急性支气管炎痰热壅肺证之咳嗽、咯痰、肺部体征疗效分别达到87.20%、81.71%、80.37%(全分析数据集),与对照组相当,且全分析数据集和符合方案数据集分析结论一致.两组患儿主要症状疗效、次要症状疗效、疾病疗效、

  4. 氨溴索、布地奈德雾化吸入联合治疗慢支急性发作的临床疗效%Ambroxol and Budesonide Aerosol Inhalation in Treatment of Acute Exacerbation of Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    董凤霞

    2015-01-01

    目的:探讨氨溴索、布地奈德雾化吸入联合治疗慢支急性发作的临床疗效。方法选取2012年10月~2014年9月在我院接受治疗的慢支急性发作患者108例,并根据患者具体情况分为观察组和对照组各54例,对照组采用常规综合方法进行治疗,观察组在对照组基础上加用氨溴索、布地奈德雾化吸入联合治疗,观察并比较两组的治疗效果。结果观察组患者治疗总有效率为94.5%,对照组为85.2%,观察组明显高于对照组,P<0.05,具有统计学意义;治疗前两组患者体温、C反应蛋白、白细胞、血沉、中性粒细胞均值无明显差异,治疗后均下降,下降幅度观察组明显高于对照组,P<0.05,具有统计学意义。结论氨溴索、布地奈德雾化吸入联合治疗慢支急性发作疗效显著,安全稳定。%ObjectiveTo study the effect of Ambroxol and Budesonide aerosol inhalation in treatment of acute exacerbation of chronic bronchitis. MethodsFrom October 2012 to September 2014 in our hospital, 108 cases of patients with acute attack of chronic bronchitis were divided into observation group and control group 54 cases, control group was treated with the conventional synthesis methods, observation group in the control group on the basis of the total ammonia bromine rope, combination treatment with budesonide atomization inhalation, observed and compared the therapeutic effect of two groups.Results The observation group of patients treatment the total effective rate was 94.5%, control group was 85.2%, the observation group is signiifcantly higher than the control group,P<0.05, there was statistically signiifcant. Two groups of patients before treatment temperature, c-reactive protein, white blood cells, blood sedimentation, neutrophils mean no signiifcant difference, decreased after treatment, the decline in observation group is significantly higher than the control group,P<0.05, with statistical

  5. 哌拉西林他唑巴坦治疗慢性支气管炎急性发作120例临床疗效观察%Piperacillin Tazobactam Treatment of Acute Exacerbation of Chronic Bronchitis, 120 Cases of Clinical Observation

    Institute of Scientific and Technical Information of China (English)

    高成兵; 汪平; 幸仕洪; 王珏

    2013-01-01

    目的:研究分析采用哌拉西林他唑巴坦治疗慢性支气管炎急性发作的临床措施和效果。方法回顾性分析2010年3月~2012年3月,我院收治的120例慢性支气管炎急性发作患者的临床资料,按照患者入院治疗的时间顺序将其随机分为两组,单号入院患者为观察组,共60例,采用哌拉西林他唑巴坦联合氨溴索治疗;双号入院患者为对照组,60例,采用氨苄西林联合氨溴索治疗。比较两组患者的临床疗效和各项临床症状缓解的时间。结果治疗后观察组患者的治疗有效率为96.67%,对照组患者的治疗有效率为86.67%,两组比较差异明显,具有统计学意义,(P<0.05);且观察组患者的各项临床症状的缓解时间短于对照组,两组比较差异明显,具有统计学意义,(P<0.05)。结论哌拉西林他唑巴坦是治疗慢性支气管炎急性发作的良好药物,临床疗效显著,安全性高,值得临床推广。%Objective: To study the methods and Effect of treating acute exacerbation of chronic bronchitis with piperacillin-tazobactam. Methods: Choosed 120 cases of acute exacerbation of chronic bronchitis to divide into study group and controlled group with 60 cases in each group. The study group were treated with piperacillin-tazobactam and ambroxol, the controlled group were treated with ampicillin and ambroxol. Compared the clinicallEffect and remission time. Results: The clinicallEffect of study group was 96.67%, higher than 86.67% of controlled group. And the remission time of study group was shorter than controlled group. Conclusion: Treating acute exacerbation of chronic bronchitis with piperacillin-tazobactam receive bet er Effects and high safety to extend in clinic.

  6. 阿奇霉素与左氧氟沙星治疗慢性支气管炎急性发作的疗效和安全性比较研究%Azithromycin and levofloxacin in treatment of acute exacerbations of chronic bronchitis curative effect and the security of the comparative study

    Institute of Scientific and Technical Information of China (English)

    王艳碧

    2012-01-01

      目的:探讨阿奇霉素与左氧氟沙星治疗慢性支气管炎急性发作的临床疗效.方法:本研究于2010年8月~2012年2月分别采用阿奇霉素和左氧氟沙星治疗慢性支气管炎急性发作患者,并对两种药物治疗的临床疗效和不良反应进行对比研究.结果:研研究组在用药3d、6d 及用药后1d 的临床总有效率与对照组相比较均无明显差异(P 均﹥0.05).研究组在治疗过程中出现1例恶心、胃部不舒服,1例头晕;对照组则在治疗过程中出现2例恶心、1例头晕.经对症治疗后症状均缓解,未影响治疗.结论:使用口服阿奇霉素5 d 与口服左氧氟沙星7 d 治疗慢性支气管炎急性发作均有较好的临床治疗效果,且安全性良好,值得临床推广使用.%  Objective: To investigate the azithromycin and levofloxacin in treatment of acute exacerbations of chronic bronchitis clinical curative effect. Methods: This study in 2010 August ~ 2012 year in February respectively with azithromycin and levofloxacin in the treatment of patients with acute exacerbations of chronic bronchitis, and two kinds of drugs for the treatment of clinical efficacy and adverse reaction were studied. Results: the research group at the 3D 6D medication, treatment and after 1D total clinical efficiency as compared with the control group showed no significant difference ( P al ﹥0.05). The study group emerged in the course of treatment in 1 cases of nausea, upset stomach, 1 cases of dizziness;while the control group emerged in the course of treatment in 2 cases, 1 cases of dizziness nausea. After the symptomatic treatment, symptoms were relieved in al patients, no impact. Conclusion: the use of oral azithromycin 5 d with oral levofloxacin in treatment of acute exacerbations of chronic bronchitis 7 d has good clinical curative effect, and good safety, is worthy of clinical use.

  7. 沙丁胺醇雾化吸入联合沉香饮加减治疗慢性喘息性支气管炎急性发作的疗效观察%Efficacy observation on treating acute exacerbation of chronic asthmatic bronchitis with the albuterol inhalation joint the Chenxiang decoction

    Institute of Scientific and Technical Information of China (English)

    潘君贤

    2012-01-01

      Objective:To analyze and investigate the clinical effect of treating acute exacerbation chronic asthmatic bronchitis with the albuterol inhalation of joint the Chenxiang decoction. Methods: Retrospective analyzing 20 patients with acute exacerbation of chronic asthmatic bronchitis in our hospital from January 2009 to December 2011, and plus salbutamol solution (1ml, 2 times a day) joint the Chenxiang decoction for treatment, in accordance with the evaluation standard, the analysis and observation of clinical efficacy in the treatment of this group of patients. Results: ①After treatment, markedly in 12 cases, effective in 7 cases, and ineffective in 1 case, the total effective rate of 95.0%. During treatment, symptoms of palpitations in 2 cases, 1 case of patient had symptoms of nausea, and adverse reactions disappear after medicine withdrawal. ②Pre-treatment lung function parameters (FEV1 and PEFR) were significantly lower than after treatment (2 weeks), and both showed a statistically significant difference. Conclusion:Treating acute exacerbation of chronic asthmatic bronchitis with the albuterol inhalation joint the Chenxiang decoction, its clinical efficacy, should be generalized and applied in clinical.%  目的:对沙丁胺醇雾化吸入联合沉香饮加减用于治疗慢性喘息性支气管炎的临床疗效进行分析与探究.方法:回顾性分析了2009年1月~2011年12月入住我院的20例慢性喘息性支气管炎急性发作的患者的临床资料,并向其加用沙丁胺醇雾化吸入溶液(1ml,每天2次)联合沉香饮加减饮进行治疗,按照相关的疗效评定标准,对本组患者在该种治疗方法下的临床疗效进行分析与观察.结果:①经过上述治疗方法的应用,显效例数12例,有效例数7例,无效例数为1例总有效率为95.0%.在治疗过程中,有2例出现心悸症状,1例出现恶心症状,停药之后不良反应均消失.②治疗前肺功能参数(FEV1与PEFR)要明显低

  8. The Efficacy of Tanreqing for Treating Acute Exacerbation of Chronic Bronchitis and Its Impact on Immunoglobulin Levels of IgA, IgG and IgM%痰热清治疗慢性支气管炎急性发作的疗效及对免疫球蛋白IgA、IgG和IgM的影响

    Institute of Scientific and Technical Information of China (English)

    王琼

    2013-01-01

      [目的]探讨痰热清治疗慢性支气管炎(chronic bronchitis,CB)急性发作的疗效及对免疫球蛋白IgA、IgG和IgM的影响。[方法]将自2011年2月至2012年2月我院收治的60例CB急性发作患者随机分为对照组和观察组,每组30例。所有患者均给予基础治疗,对照组在基础治疗上给予庆大霉素、地塞米松、α糜蛋白酶雾化吸入,观察组则在基础治疗上给予痰热清注射液静脉滴注,观察两组患者的疗效、临床症状改善情况及免疫球蛋白IgA、IgG和IgM水平变化情况。[结果]观察组患者的总有效率为96.67%显著高于对照组的80%(χ2=4.04,P<0.05);观察组各临床症状的改善时间均明显短于对照组(P<0.05);观察组治疗后免疫球蛋白IgA、IgG和IgM的水平显著低于对照组(P<0.05)。[结论]采用痰热清治疗CB急性发作疗效显著,能有效缩短临床症状的缓解时间,改善免疫球蛋白IgA、IgG和IgM的水平,增强机体免疫功能,促进患者尽快康复。%  [Objective]To explore the clinical efficacy of Tanreqing for treating acute exacerbation of chronic bronchitis and its impact on immunoglobulin levels of IgA, IgG and IgM. [Methods] 60 cases with acute exacerbation of chronic bronchitis admitted in our hospital from February 2010 to February 2012 were randomly divided into control group and observation group, and each group had 30 cases. Al of the patients were given basic treatment; the control group was given gentamicin, dexamethasone and alpha chymotrypsin aerosol inhalation on the basis of the basic treatment, while the observation group was given Tanreqing intravenous injection;the efficacy, clinical symptoms improving situation and the changes of immunoglobulin levels of IgG and IgM were compared between the two groups. [Results] The total effective rate of the observation group was 96.67% significantly higher than 80% of the control group(χ2=4.04); the

  9. Effect observation of salmeterol xinafoate and fluticasone propionate pow-der for inhalation in the treatment of acute attack of chronic bronchitis%沙美特罗替卡松粉吸入剂治疗慢性支气管炎急性发作的效果观察

    Institute of Scientific and Technical Information of China (English)

    肖亮

    2014-01-01

    目的:观察沙美特罗替卡松粉吸入剂治疗慢性支气管炎急性发作的临床效果。方法选取本院2012年2月~2014年2月收治的68例慢性支气管炎急性发作患者为研究对象,按照随机数字表法将其分为两组,各34例。对照组采取吸氧、平喘、抗感染、吸痰等常规治疗,实验组在对照组基础上加用沙美特罗替卡松粉吸入剂治疗,比较两组的治疗效果及不良反应情况。结果实验组中临床治愈19例(55.88%),显效8例(23.53%),好转5例(14.71%),总有效率为94.12%,对照组临床治愈14例(41.18%),显效8例(23.53%),好转3例(8.82%),总有效率为73.53%,实验组的总有效率明显高于对照组(P0.05)。结论沙美特罗替卡松粉吸入剂能明显改善临床症状,且不良反应少,值得在慢性支气管炎急性发作患者中进一步应用。%Objective To observe the clinical effect of salmeterol xinafoate and fluticasone propionate powder for in-halation in the treatment of acute attack of chronic bronchitis. Methods From February 2012 to February 2014,68 pa-tients with acute attack of chronic bronchitis admitted into our hospital were selected as research objects and they were evenly divided into two groups according to the random number table method.In the control group,regular treatment in-cluding oxygen uptake,anti-asthma,anti-infection,and aspiration of sputum were provided, while in the experimental group,on the basis of treatment the control group, salmeterol xinafoate and fluticasone propionate powder for inhalation was added. The clinical effect and adverse reaction in the two groups were compared. Results In the experimental group,19 cases (55.88%) were cured clinically,8 cases were markedly efective (23.53%),5 cases (14.71%) were improved, the total effective rate was 94.12%,while in the control group,14 cases (41.18%) were clinically cured,8 cases (23.53%) were markedly efective,3 cases (8.82%) were improved

  10. 负离子氧疗慢性支气管炎急性发作期的临床观察及感染控制对疗效的影响%Clinical observation on negative ion of oxygen therapy for patients with acute exacerbation of chronic ;bronchitis and the efifcacy of anti-infection measures

    Institute of Scientific and Technical Information of China (English)

    于德海

    2013-01-01

    目的:探讨高浓度负离子氧疗在慢性支气管炎急性发作期治疗中的临床应用价值。方法将本院收治的106例慢性支气管炎急性发作期患者随机分为观察组和对照组,每组患者53例。对照组给予常规西药治疗,观察组在对照组基础上给予高浓度负离子氧疗,观察两组的临床症状改善情况、肺功能改善情况、实验室生化指标及临床疗效。结果观察组临床总有效率为90.6%(48/53),对照组临床总有效率为73.5%(39/53),两组差异有统计学意义(P <0.05),观察组咳嗽、喘息及肺啰音等临床症状改善情况均显著优于对照组(P <0.05),观察组FEV1、FEV1/FVC、p(O2)及p(CO2)的肺功能各项指标改善情况显著优于对照组(P <0.05),观察组CRP、PCT及WBC等实验室生化指标也均显著优于对照组(P <0.05)。结论高浓度负离子氧疗能显著提高慢性支气管炎急性发作期的临床疗效,具有重要的临床应用价值。%Objective To explore clinical efifcacy of high concentration negative ions of oxygen therapy for patients with acute exacerbation of chronic bronchitis. Methods Total of 106 patients with acute exacerbation of chronic bronchitis were randomly divided into two groups with 53 cases in each group, the observation group treated with the conventional therapy plus adjuvant treatment of high concentration negative ions of oxygen were compared with the control group treated with conventional therapy. The clinical efifcacy of the two groups was observed. Results The clinical efifciency of the observation group was 90.6%, the clinical efifciency of the control group was 73.5%, the clinical symptoms and serum biochemical indicators of the observation group was signiifcantly better than that of the control group, with signiifcant difference (P<0.05). Conclusions High concentration negative ions of oxygen therapy can signiifcantly improve the clinical

  11. 布地奈德雾化吸入治疗小儿急性喉-气管-支气管炎的疗效观察及护理%Curative Effect Observation and Nursing of Budesonide Aerosol Inhalation Treatment of Infantile Acute Laryngeal Airway-bronchitis

    Institute of Scientific and Technical Information of China (English)

    韩春芳

    2015-01-01

    Objective To observe the budesonide suspension liquid atomization inhalation treatment of infantile acute laryngeal airway-bronchitis curative effect and nursing.Methods To observe the group of 60 cases, given budesonide suspension liquid oxygen gas atomization inhalation; the control group of 60 cases of intravenous drip given dexamethasone. Two groups adopt corresponding nursing measures, observation of symptoms in both groups.Results Observation group suction throat singing disappear time, barking cough time, loss of hearing time is shorter than the control group, and difference was statistically signiifcant (P<0.05).Conclusion Budesonide aerosol inhalation treatment of infantile acute laryngeal airway-bronchitis, good curative effect, the small dose of drug, can signiifcantly shorten the duration of symptoms, side effects.%目的:观察布地奈德混悬液(普米克令舒)雾化吸入治疗小儿急性喉-气管-支气管炎的疗效及护理。方法观察组60例患儿给予布地奈德混悬液氧气驱动雾化吸入;对照组60例患儿给予地塞米松静脉滴注。两组均采用相应地护理措施,观察两组患者症状缓解时间。结果观察组吸气喉鸣消失时间、犬吠样咳嗽消失时间、声嘶消失时间均短于对照组,差异有统计学意义P<0.05。结论布地奈德雾化吸入治疗小儿急性喉-气管-支气管炎,疗效好,所用药物剂量小,能明显缩短病程,不良反应小。

  12. 鸡传染性支气管炎病毒HN104株的鉴定及S1基因的分子特征%Identification and Molecular Characterization of an Avian Infectious Bronchitis Virus Strain HN104

    Institute of Scientific and Technical Information of China (English)

    刘文杰; 王忠田; 李新生; 王泽仁; 李燕; 李双亮; 崔保安

    2011-01-01

    A virus was isolated from a suspected of suffering from avian infectious bronchitis chicken farms in Henan province in April 2010. The virus was confirmed as a genetic variation occurred avian infectious bronchitis virus by SPF chicken embryos induced dwarf experiment, chicken red blood cell agglutination test,interference with Newcastle disease virus proliferation assay and RT-PCR tests. Its allantoic fluid hemagglutination titer which for chicken red blood cells was 0. However, viruses' HA titer was 27 after treatment by trypsin.EID50 (50% egg infectious dose) was 10-5.5/0.1 mL; It could significantly interfere with Newcastle Disease Virus La Sota strain proliferation in the chick embryo; SPF chickens infection experiments showed that the virus could cause swelling of the kidney and spotted kidney. The S1 cDNA was 1617 bp.Phylogenetic tree showed that the kinship between IBV Massachusetts strain, T strain and 4/91 strain was distantly related less than 78%.%2010年4月从河南省某疑似患鸡传染性支气管炎鸡场中分离到一株病毒.通过SPF鸡胚致侏儒实验,鸡红细胞凝集试验,干扰新城疫病毒增殖试验和RT-PCR试验确认该病毒为一变异的鸡传染性支气管炎病毒.该病毒尿囊液凝集鸡红细胞的HA价为0,经胰酶处理后为27;EID50(鸡胚半数感染量)为10-5.5/0.1 mL;能够显著干扰鸡新城疫病毒La Sota株在鸡胚中的增殖;动物回归试验结果显示该病毒可致SPF雏鸡出现肾脏肿大,呈花斑肾.其S1基因全长为1617bp,经序列分析发现与鸡传染性支气管炎疫苗Massachusetts株、T株、4/91株亲缘关系较远低于78%.

  13. 小鼠嗜酸粒细胞性支气管炎模型与哮喘模型的蛋白组学差异表达分析%Analysis of Comparative Proteomics of Eosinophilic Bronchitis Mouse Model and Asthma Mouse Model

    Institute of Scientific and Technical Information of China (English)

    谢佳星; 张清玲; 陈莉延; 罗炜; 赖克方; 钟南山

    2014-01-01

    【目的】探讨小鼠嗜酸粒细胞性支气管炎模型(EB模型)与哮喘模型的蛋白组学差异表达。【方法】EB模型小鼠(实验组)、哮喘模型小鼠(哮喘组)及对照组小鼠各4只,取肺组织提取总蛋白质,采用基质辅助电离解析飞行时间质谱对蛋白质进行序列分析,并比较三组肺组织蛋白差异。【结果】双向电泳图像显示三组肺组织蛋白表达比较差异有显著性(P<0.05),经质谱检测肽质量指纹谱与标准分子量、等电点对照分析鉴定出20个蛋白,分别为谷胱甘肽-S-转移酶 M1(GSTM1)、热休克蛋白 B1(HSPB1)等,其中 GSTM1在哮喘组表达下调、HSPB1在哮喘组表达上调。【结论】GSTM1、HSPB1等可能参与气道高反应性的发生机制。%[Obj ective]To explore the differential expression of proteomics of eosinophilic bronchitis mouse model and asthma mouse model.[Methods]Four rats in each group including eosinophilic bronchitis model(EB model)(experimental group),asthma model(asthma group)and control group.Total protein was extracted from lung tissue.Matrix-assisted laser desorption/ionization time of flight mass spectrometry was used for sequence a-nalysis of proteins.[Results]Two dimensional electrophoresis image showed that there was difference in the ex-pression of protein among 3 groups(P<0.05).Twenty proteins such as glutathione-S-transferase M1(GSTM1) and heat shock protein B1(HSPB1)were identified through the analysis of peptide mass fingerprint spectrum of mass spectrometry contrasted with standard molecular weight and isoelectric point.GSTM1 was down-regulated in asthma group,while HSPB1 was up-regulated in asthma group.[Conclusion]GSTM1 and HSPB1 may involve in the occurrence of airway hyperresponsiveness.

  14. Observation of the application effect of health education nursing intervention in elderly patients with chronic bronchitis%老年慢性支气管炎患者应用健康教育护理干预的效果观察

    Institute of Scientific and Technical Information of China (English)

    王晨英

    2015-01-01

    Objective:To explore the application effect of health education nursing intervention in elderly patients with chronic bronchitis.Methods:120 elderly patients with chronic bronchitis were selected.They were randomly divided into the control group and the observation group with 60 cases in each group.The control group was given routine nursing intervention,and the observation group was given nursing intervention of health education.Results:In the control group,23 cases(38.33%) changed their bad living habits,31 cases(51.67%) quitted smoking and drinking;in the observation group,50 cases(83.33%) changed their bad living habits,59 cases(98.33% ) quitted smoking and drinking,the different was statistically significant(P<0.05).In the control group,the average recurrence time was 115 days,average one treatment time was 12 days;in the observation group,the average recurrence time was 194 days,average one treatment time was 7 days.Conclusion:Health education nursing intervention had very good curative effect in clinic.It can shorten the course of treatment in patients,and delay patients recurrence time.%目的:探讨对老年慢性支气管炎患者应用健康教育护理干预的治疗效果。方法:收治老年慢性支气管炎患者120例,随机平均分为对照组和观察组,对照组采用常规护理干预,观察组采用健康教育护理干预。结果:对照组逐渐改变自己的生活习惯23例(38.33%),戒烟戒酒31例(51.67%);观察组改变自己不良的生活习惯50例(83.33%),戒烟戒酒59例(98.33%)。两组比较,差异有统计学意义(P<0.05)。对照组再次复发时间平均115 d,1个疗程时间平均12 d;观察组再次复发时间平均194 d,1个疗程时间平均7 d。结论:健康教育护理干预在临床上取得了非常好的疗效,可缩短患者的治疗时间,延缓患者的再次复发时间。

  15. Clinical effect study of Puji-Xuanfei-Xiaodu decoction on acute bronchitis of exterior cold and interior heat%普济宣肺消毒饮对表寒里热型急性支气管炎咳嗽的干预作用

    Institute of Scientific and Technical Information of China (English)

    郭来; 齐文升; 杨秀捷; 刘萍

    2015-01-01

    目的:观察普济宣肺消毒饮对急性支气管炎的止咳作用。方法收集2010年5月-2013年11月中国中医科学院广安门医院急诊科、急诊内科门诊急性支气管炎(表寒里热型)患者,按照随机数字表随机分为治疗组44例和对照组43例。治疗组给予普济宣肺消毒饮治疗,对照组给予急支糖浆治疗,观察2组对咳嗽及咳痰、发热、头痛等症状的影响,疗程均为7 d。结果止咳方面,治疗组痊愈63.6%(28/44)、有效29.5%(13/44),总有效率93.2%(41/44);对照组痊愈34.9%(15/43)、有效53.5%(23/43),总有效率88.4%(38/43)。2组总有效率比较差异有统计学意义(χ2=10.439,P=0.001)。2组咳嗽咳痰、发热、头痛、恶风等证候疗效比较,治疗组痊愈50.0%(22/44)、显效25.0%(11/44)、有效18.2%(8/44),总有效率为93.2%(41/44);对照组痊愈32.6%(14/43)、显效18.6(8/43)、有效27.9%(12/43),总有效率为79.1%(34/43),2组总有效率比较差异无统计学意义(χ2=3.642,P=0.056)。结论普济宣肺消毒饮有一定止咳作用。%Objective To study the relieving cough effect ofPuji-Xuanfei-Xiaodu decoction on acute bronchitis.Methods 87 patients with acute bronchitis of exterior cold and interior heat were randomly divided into two groups(44 cases in a therapy group and 43 cases in a control group).Puji-Xuanfei-Xiaodu decoction was given to the patients in the therapy group and acute bronchitis syrup was given to the control group, to observe the influence on symptoms of cough, sputum, fever and headache. The course of treatment was 7 days. Results On the reliving cough aspect, 28 cases (63.6%) showed cure effect and 13 cases (29.5%) effctive, the total effective rate was 93.2% in therapy group with 44 cases; while in control group (43 cases), 15 cases (43.9%) showed cure effect and 23 cases (53.5%) effctive, the total effective rate was 88

  16. The Effects of Triple Inhalation Therapy of Budesonide, Terbutaline Sulphate and Ipratropium Bromide in Children with Asthmatic Bronchitis%布地奈德、硫酸特布他林、异丙托溴铵气雾剂三联气泵雾化吸入治疗小儿喘息性支气管炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    魏向阳; 滕永华

    2012-01-01

    Objective:To observe the effects of triple inhalation therapy of budesonide, terbutaline sulphate and ipratropium bromide in children with asthmatic bronchitis. Methods: Randomly 122 cases of asthmatic bronchitis were divided into a treatment group of 62 patients, and a control group of 60 patients. Treatment group was treated with budesonide, terbutaline sulphate and ipratropium bromide inhalation. Patients weighing less than 10 kg received Pulmicort 1 mL, Bricanyl 0.5 mL, and Atrovenl 0. 25 mL 2 to 3 limes daily; while those weighting greater than 10 kg received Pulmicort 1 mL, Bricanyl 1 mL, and Atrovent 0.5 mL 2 to 3 times dairy. In each inhalation 2 mL of normal saline was mixed into aerosol pump. Symptoms and signs before and after treatment, and the course of disease were compared. Results: The clinical symptoms disappearance time and pulmonary rales disappearance time of the treatment group were shorter than those of the control group ( P<0.01). The treatment group's total effective rate was 95.6% 09 opposed to the control group (with a total effective rate of 75.0%); the difference was statistically significant (P<0.01). Conclusions: Budesonide, terbutaline sulphate and ipratropium bromide combined inhalation therapy can shorten the course of asthmatic bronchitis, increase the cure rate, and decrease adverse reactions.%目的:观察布地奈德、硫酸特布他林、异丙托溴铵气雾剂联合雾化吸入治疗喘息性支气管炎的临床疗效.方法:将122例喘息性支气管炎患儿随机分为治疗组62例、对照组60例,两组采用相同的抗感染、止咳、平喘等综合治疗.治疗组加用布地奈德、硫酸特布他林、异丙托溴铵气雾剂雾化吸入,体重小于10 kg者,予布地奈德1 mL、硫酸特布他林0.5mL、异丙托溴铵气雾剂0.25 mL;体重大于10 kg者予布地奈德1 mL、硫酸特布他林1 mL、异丙托溴铵气雾剂0.5 mL,均加生理盐水2 mL混合后放雾化器中经压力雾化泵吸入,每

  17. 氧驱动雾化吸入重组人干扰素-α2a注射液治疗婴幼儿毛细支气管炎的疗效观察%Observation of curative effects of oxygen-driven atomized inhalation of recombinant human interferon-α2a injection in the treatment of infantile capillary bronchitis

    Institute of Scientific and Technical Information of China (English)

    王国权; 吴晓兰; 邹富梅

    2015-01-01

    Objective To explore the clinical effects of oxygen-driven atomized inhalation of recombinant human inter-feron-α2a injection in the treatment of infantile capillary bronchitis. Methods 240 infant patients with capillary bron-chitis were assigned to a control group and a treatment group according to their disease conditions, with 120 patients in each group. The control group received regular treatment(oxygen uptake, atomized inhalation of pulmicort respulas+nebulized terbutaline sulphate solution used for anti-inflammation and antiasthma, aspiration of sputum, antibiotics giv-en to infants suspected to be complicated with bacterial infection, intravenous drip of methylprednisolone given to in-fants with severe symptoms, etc.); The treatment group further received oxygen-driven atomized inhalation of 600,000 international units of recombinant human interferon-α2a injection, once a day for 5 days. Clinical effects and main ob-servational indices between the two groups were compared. Results Total effective rate was 95.0% in the treatment group and 78.3%in the control group, and the differences between the two groups were statistically significantly(P<0.05). Alleviating time of asthma, disappearing time of lung rale, time of persistent cough and hospitalization time in the treatment group were all lower than those in the control group, and the differences between the two groups were statisti cally significant (P<0.05). Significant adverse events were not detected during the treatment period of oxygen-driven atomized inhalation of recombinant human interferon-α2a injection applied by the infant patients. Conclusion Oxygen-driven atomized inhalation of recombinant human interferon-α 2a injection in the treatment of infantile capillary bron-chitis has an exact curative effect, and it is safe, which is worthy of clinical pediatric promotion and application.%目的:探讨氧气驱动雾化吸入重组人干扰素-α2a注射液治疗婴幼儿毛细支气管

  18. Risco aumentado de sintomas respiratórios e bronquite crônica em mulheres que utilizam biocombustíveis na Nigéria Increased risk of respiratory symptoms and chronic bronchitis in women using biomass fuels in Nigeria

    Directory of Open Access Journals (Sweden)

    Olufemi Olumuyiwa Desalu

    2010-08-01

    Full Text Available OBJETIVO: Determinar a associação de sintomas respiratórios e bronquite crônica com o uso de biocombustíveis entre mulheres habitantes de áreas rurais do estado de Ekiti, sudoeste da Nigéria. MÉTODOS: De janeiro a junho de 2009, realizou-se um estudo transversal com uma amostra de 269 mulheres adultas. Um questionário adaptado do European Community Respiratory Health Survey foi aplicado para a obtenção de dados sobre características sociodemográficas, tipo de combustível utilizado para a preparação de alimentos, sintomas respiratórios e história de tabagismo. Todas as participantes foram convidadas a realizar espirometria. RESULTADOS: Das 269 mulheres no estudo, 161 (59,9% utilizavam biocombustíveis para a preparação de alimentos. As mulheres que utilizavam biocombustíveis relataram mais sintomas respiratórios que aquelas que não os utilizavam - tosse (13,7% vs. 3,7%; sibilância (8,7% vs. 2,8%; dor no peito (7,5% vs. 1,9%; falta de ar (11,8% vs. 6,5%; sintomas nasais (9,3% vs. 4,6%; e bronquite crônica (10,6% vs. 2,8%. A análise multivariada por regressão logística confirmou que o uso de biocombustíveis está associado às seguintes variáveis: tosse (OR = 4,82; p = 0,01; bronquite crônica (OR = 3,75; p = 0,04; sibilância (OR = 2,22; p = 0,23; dor no peito (OR = 3,82; p = 0,09; falta de ar (OR = 1,54; p = 0,35; e sintomas nasais (OR = 2,32; p = 0,20. Todos os parâmetros espirométricos avaliados (VEF1, CVF, VEF1/CVF e PFE foram menores nas mulheres que utilizavam biocombustíveis do que naquelas que não os utilizavam. CONCLUSÕES: Nossos resultados enfatizam a necessidade de se substituir o uso de biocombustíveis nos domicílios pelo de um tipo de combustível atóxico, como eletricidade ou gás.OBJECTIVE: To determine whether respiratory symptoms and chronic bronchitis are associated with the use of biomass fuels (BMFs among women residing in rural areas of the Ekiti State, in southwestern Nigeria. METHODS

  19. Detección y caracterización del virus de bronquitis infecciosa aviaria en Chile mediante RT-PCR y análisis secuencial Detection and characterization of infectious bronchitis virus in Chile by RT-PCR and sequence analysis

    Directory of Open Access Journals (Sweden)

    J C Lopez

    2006-01-01

    Full Text Available Una técnica de reacción en cadena de la polimerasa transcriptasa reversa (RT-PCR junto a una secuenciación fue usada para detectar y caracterizar genéticamente virus diferentes de bronquitis infecciosa aviar (VBIA aislados en Chile. El procedimiento de RT-PCR incluyó el uso de los partidores NT1 y NT2, los cuales se localizaron cerca del término N del gen S1 y cubrieron la región hipervariable. La secuencia amplificada fue alineada y analizada con el programa computacional DNAman, y comparada con secuencias reportadas en GenBank. El nivel de detección de la técnica de RT-PCR fue equivalente al aislamiento viral en huevos cuando se usaron directamente tejidos, pero el ensayo fue más sensitivo cuando fue usado para detectar virus almacenados en fluido alantoideo. Los amplificados de todos los aislados históricos de Chile fueron idénticos en tamaño (193pb y exhibieron entre ellos, al analizar la secuencia una similitud del 71 al 96%. Estos aislados mostraron entre 68 y 97% de similitud con cepas de Estados Unidos, Europa, Asia, Nueva Zelandia y Australia.A reverse transcriptase-polymerase chain reaction (RT-PCR assay, coupled with sequencing, was used to detect and genetically characterize different infectious bronchitis virus (IBV isolates in Chile. The RT-PCR procedure included the use of the primers NT1 and NT2 that were located close to the N-terminus of the S1 gene and bracketed the hypervariable region, and the amplified sequences were aligned and analyzed with DNAman software, and compared with sequences from GenBank. The level of detection of the RTPCR assay was equivalent to virus isolation in eggs when testing tissues directly, but the assay was more sensitive when used to detect virus stored in allantoic fluid. The amplimers from all historical Chilean isolates were identical in size (193 bp and exhibited 71-96% similarity on sequence analysis. These isolates showed between 68-97% similarity to strains from North America

  20. [Lung dysfunction in patients with mild chronic obstructive bronchitis].

    Science.gov (United States)

    Nefedov, V B; Popova, L A; Shergina, E A

    2004-01-01

    VC, FVC, FEV1, FEV1/VC%, PEF, MEF25, MEF50, MEF75, TCL, TGV, RV, Ravt, Riin, Rex, DLCO-SS, PaO2, and PaO2 were determined in 33 patients with mild chronic obstructive lung disease (FEV1 > 70% of the normal value). All the patients were found to have impaired bronchial patency; most (63.6%) patients had lung volume and capacity changes, almost half (45.5%) the patients had pulmonary gas exchange dysfunction. Impaired bronchial patency mainly appeared as decreased MEF50, MEF15, and FEV1/VC%; altered lung volumes and capacities manifested chiefly by increased RV and decreased VC; pulmonary gas exchange dysfunction showed up primarily as lowered PaO2. The magnitude of the observed functional changes was generally slight. MEF50, MEF75, FEV1/VC%, and VC dropped to 59-20 and 79-70% of the normal value, respectively. RV increased up to 142-196% of the normal value; PaO2 reduced up to 79-60% mm Hg. PMID:15478560

  1. [Lung dysfunction in patients with severe chronic obstructive bronchitis].

    Science.gov (United States)

    Nefedov, V B; Popova, L A; Shergina, E A

    2005-01-01

    VC, FVC, FEV1, FEV1/VC%, PEF, MEF25, MEF50, MEF75, TCL, TGV, RV, Raw, Rin, Rex, DLCO-SS, PaO2, and PaCO2 were determined in 36 patients with severe chronic obstructive lung disease (FEV1 TGV, and TLC, and by decreased VC and FVC; pulmonary gas exchange dysfunction showed up as lowered PaO2 and DLCO-SS, as decreased or increased PaCO2. The observed bronchial patency disorders varied from significant to severe; functional changes in lung volumes and capacities were mild to severe. PMID:15938497

  2. Air pollutants, genes and early childhood acute bronchitis

    Czech Academy of Sciences Publication Activity Database

    Ghosh, R.; Topinka, Jan; Joad, J.P.; Dostál, Miroslav; Šrám, Radim; Hertz-Picciotto, I.

    2013-01-01

    Roč. 749, 1-2 (2013), s. 80-86. ISSN 0027-5107 R&D Projects: GA MŽP(CZ) SP/1B3/50/07 Institutional support: RVO:68378041 Keywords : PAH * respiratory illness * interaction Subject RIV: DN - Health Impact of the Environment Quality Impact factor: 4.440, year: 2013

  3. Living Well with COPD: Chronic Bronchitis and Emphysema

    Science.gov (United States)

    ... the airways • These are not the same as anabolic steroids,which are muscle-building steroids often misused by ... not to be confused Air sacs (alveoli) with anabolic steroids used by athletes and others to build muscles. ...

  4. Diagnosis and treatment of patients with atrophic deforming bronchitis

    International Nuclear Information System (INIS)

    Ninety seven patients were treated with laser radiation. A treatment course involved 5 to 7 exposures to radiation every second day. An exposure lasted 300 sec. As a result of treatment, cough completely ceased in 94 patients (96,9%). There was also a positive dynamics in the ultrastructural study of biopsy specimens taken prior to and following the therapy

  5. Study on efficacy and influence of montelukast on bronchitis symptoms and wheezing in treatment of bronchiolitis caused by respiratory ;syncytial virus%孟鲁司特治疗呼吸道合胞病毒感染的毛细支气管炎的疗效及对气管炎症和再次喘息的影响

    Institute of Scientific and Technical Information of China (English)

    陈英; 李居武; 于飞

    2015-01-01

    目的:探讨孟鲁司特治疗呼吸道合胞病毒感染的毛细支气管炎的疗效及对气管炎症和再次喘息的影响。方法选择呼吸道合胞病毒感染的毛细支气管炎患儿120例随机分为观察组与对照组各60例,对照组给予镇咳、平喘、抗病毒等常规治疗,观察组在常规治疗的基础上再给予孟鲁司特维持治疗12周,比较两组患儿治疗有效率、喘息改善时间、平均住院时间,治疗前、后血清半胱氨酰白三烯( CysLTs)、嗜酸粒细胞阳离子蛋白( ECP)水平及再次喘息发生率。结果①观察组治疗有效率为100%,明显高于对照组的88.33%,差异有统计学意义( P ﹤0.05)。②观察组喘息改善时间、平均住院时间较对照组短,差异有统计学意义( P ﹤0.05)。③两组治疗后CysLTs、ECP水平较治疗前明显降低,观察组治疗后CysLTs、ECP水平较对照组降低明显,差异有统计学意义(均P ﹤0.05);④观察组治疗12周再次喘息发生率为18.33%,明显低于对照组的33.33%,比较差异有统计学意义( P ﹤0.05)。结论孟鲁司特治疗呼吸道合胞病毒感染性毛细支气管炎显效较快,可有效抑制气管炎症,减少喘息复发。%Objective To explore the efficacy and influence of montellukast on bronchitis symptoms and wheezing in treatment of bronchi-olitis caused by respiratory syncytial virus. Methods A total of 120 patients with bronchiolitis caused by respiratory syncytial virus were selected, and they were randomly divided into observation group and control group,60 cases in each group. Patients in control group were treated with con-ventional treatment including anti-coughing,anti-asthma,anti-virus,etc,patients in observation group were treated with montelukast mainte-nance treatment for 12 weeks on the basis of conventional therapy,efficiency,duration for improvement of asthma,average length of hospital stay, serum levels of

  6. Detecção molecular de vírus da bronquite infecciosa em plantéis de avós, matrizes e frangos de corte no Rio Grande do Sul e Mato Grosso Molecular detection of infectious bronchitis virus in flocks of grandmothers, mothers and broiler chicken in Rio Grande do Sul and Mato Grosso

    Directory of Open Access Journals (Sweden)

    Bárbara Nascimento

    2013-03-01

    Full Text Available O vírus da Bronquite Infecciosa das galinhas (VBI pertence ao grupo 3 da família Coronaviridae e é o causador de desordens respiratórias e renais em frangos de corte. A vacinação com vacinas vivas é praticada em matrizes e avós e muitas vezes também nos plantéis destinados ao abate. As vacinas utilizadas no Brasil são usualmente do sorogrupo Massachusetts e baseadas nas amostras H120 e H52. É comum que após a vacinação o vírus vacinal seja detectado por isolamento em ovos embrionados ou por métodos moleculares por até 4 semanas. Após essa data, normalmente, não há detecção de vírus e o VBI, quando encontrado, pode representar recirculação do vírus vacinal no plantel ou a introdução de uma nova cepa do vírus. No presente estudo, para avaliar a circulação do vírus em plantéis de frangos e reprodutoras nos estados do Rio Grande do Sul e Mato Grosso do Sul, foram coletadas 240 traqueias e rins de aves de 48 plantéis, sendo (20 exemplares/4 plantéis de avós, (80 exemplares/16 plantéis de matrizes e (140 exemplares/28 plantéis de frangos de corte, as quais foram analisadas em misturas de cinco amostras. Todos os animais eram vacinados e as amostras foram coletadas ao redor de 2 a 48 semanas após a vacinação. A presença de VBI foi determinada com auxílio de uma reação em cadeia da polimerase tipo nested, direcionada ao gene da proteína S1, padronizada neste estudo. Das 48 amostras testadas, 14 resultaram positivas: cinco foram oriundas de aves vacinadas há menos de quatro semanas na data da coleta e nove eram de amostras de aves vacinadas há mais de quatro semanas, o que pode ser devido à recirculação do vírus vacinal ou mesmo introdução de vírus selvagem nos plantéis.Infectious bronchitis virus (IBV, Avian Coronavirus from chickens belongs to group 3 of the family Coronaviridae and causes respiratory and renal disorders in broilers. Vaccination using live vaccines is generally performed in

  7. Associação de bronquite plástica com enteropatia perdedora de proteínas após operação de Fontan Asociación de bronquitis plástica a la enteropatía perdedora de proteínas tras operación de fontan Association of plastic bronchitis to protein-losing enteropathy after fontan operation

    Directory of Open Access Journals (Sweden)

    Vanessa Alves Guimarães

    2010-04-01

    Full Text Available Relatamos um caso incomum de associação de bronquite plástica (BP com enteropatia perdedora de proteínas (EPP em menina de 4 anos e 9 meses de idade. com dupla via de entrada de ventrículo único tipo esquerdo e concordância ventrículo-arterial submetida à cirurgia cavopulmonar total. com túnel lateral intracardíaco aos três anos. Tornaram-se chamativas a eliminação de molde brônquico de fibrina de 10 cm (BP e a elevação de alfa-1-antitripsina de 52 mg/g de fezes. Em uso de sildenafila. programou-se. em caso de continuidade do processo. a ligadura do ducto torácico e transplante cardíaco.Referimos el caso atípico de asociación de bronquitis plástica (BP con enteropatía perdedora de proteínas (EPP en una menina de 4 años y 9 meses de edad, con doble vía de entrada de ventrículo único tipo izquierdo y concordancia ventrículo-arterial sometida a la cirugía cavopulmonar total, con túnel lateral intracardiaco a los 3 años. Se consideraron como llamativas la eliminación de molde bronquial de 10 cm formado por fibrina (BP y la elevación de alfa-1-antitripsina de 52 mg/g de heces. En uso de sildenafila, se programó, en caso de continuidad del proceso, la ligadura del conducto torácico y trasplante cardíaco.We report an unusual case of association of plastic bronchitis (PB to protein-losing enteropathy (PLE in a girl of 4 years and 9 months of age with double inlet single left ventricle and ventriculoarterial concordance. submitted to total cavopulmonary surgery. with an intracardiac lateral tunnel at the age of three. The elimination of the 10 cm fibrin bronchial mold (PB and the alpha-1-antitrypsin elevation of 52 mg/g in feces had both become outstanding. Using sildenafil. the thoracic duct ligature and the cardiac transplant were programmed in case of continuity of the process.

  8. Inhibition by oral N-acetylcysteine of cigarette smoke-induced "bronchitis" in the rat.

    Science.gov (United States)

    Rogers, D F; Jeffery, P K

    1986-01-01

    Specific pathogen-free rats were exposed to the cigarette smoke (CS) of 25 cigarettes daily for 14 days and concurrently given N-acetylcysteine (Nac) as 1% of their drinking water (average daily dose 973 mg/kg). The thickness of the epithelium was measured at four airway levels and the numbers of mucus-containing secretory cells, stained for neutral or acidic glycoprotein (NGP or AGP respectively), were counted in surface epithelium at eight airway levels. Cigarette smoke increased the thickness of the epithelium at three of the airway levels studied by between 37 and 72%. The number of secretory cells was increased at all airway levels distal to the upper trachea by between 102 and 421%. Secretory cells containing NGP were reduced in number but this was more than offset by a large increase in the number of secretory cells containing AGP at all airway levels. N-acetylcysteine inhibited CS-induced epithelial thickening. Nac also inhibited the CS-induced increase in the number of secretory cells with AGP, but had little effect on the CS-induced reduction in the number of cells with NGP. Thus, prophylactic oral N-acetylcysteine led to an overall inhibition of CS-induced mucous cell hyperplasia and epithelial hypertrophy. The results suggest a novel anti-inflammatory action for a drug with known mucolytic effects. PMID:3698928

  9. Chronic bronchitis is an independently associated factor for more symptom and high-risk groups

    OpenAIRE

    Rhee, Chin Kook

    2016-01-01

    Joon Young Choi,1 Hyoung Kyu Yoon,2 Seoung Ju Park,3 Yong Bum Park,4 Kyeong-Cheol Shin,5 Ju Ock Na,6 Kwang Ha Yoo,7 Ki-Suck Jung,8 Young Kyoon Kim,1 Chin Kook Rhee1 1Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St Mary’s Hospital, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yeouido St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, 3Division of Pulmon...

  10. Early effects of intravenous terbutaline on cardiopulmonary function in chronic obstructive bronchitis and pulmonary hypertension.

    OpenAIRE

    Jones, R. M.; Stockley, R A; Bishop, J M

    1982-01-01

    Terbutaline sulphate (0.25 mg) was given intravenously to 10 recumbent patients with severe irreversible airflow obstruction and pulmonary hypertension who were undergoing right heart catheterisation. Alveolar ventilation index, cardiac index, and mean pulmonary artery pressure all rose significantly at 5 minutes and then fell by 35 minutes, although the first two remained higher than control levels. This was accompanied by a small but significant rise in arterial oxygen tension at 5 minutes....

  11. Bronquitis infecciosa aviar: diagnóstico y control -Avian infectious bronchitis: diagnosis and control

    OpenAIRE

    Acevedo Beiras, Ana María.

    2010-01-01

    ResumenLa bronquitis infecciosa aviar (BIA) es una enfermedad que ocasiona unimpacto socio-económico severo en la industria avícola mundial. Es unaenfermedad respiratoria aguda, altamente contagiosa, caracterizadaprimariamente por signos respiratorios en los pollos en crecimiento. En las ponedoras, la sintomatología respiratoria es menor pero provoca una disminución marcada en la producción y calidad del huevo. El agente etiológico de esta enfermedad es el virus de la bronquitis infecciosa av...

  12. LOSSES DUE TO INFECTIOUS BRONCHITIS VIRUS INFECTION IN LAYING AND BREEDING HENS

    OpenAIRE

    Muhammad Akram Muneer, K.Munir Chaudhry and K.Naeem Khawaja

    2000-01-01

    This study indicates that 1BV infection of laying chickens is of high economical importance as it adversely affects their production potentials. 18V-infected hens lay eggs of inferior quality compared to the uninfected hens. There were significant differences in the daily egg production, egg weight, shell weight and in the internal quality of eggs laid by the 18V infected and uninfected hens. The 1BV infection of developing embryos resulted into mortality, kidney lesions, stunting and curling...

  13. Molecular and antigenic characteristics of Massachusetts genotype infectious bronchitis coronavirus in China.

    Science.gov (United States)

    Chen, Lingfeng; Zhang, Tingting; Han, Zongxi; Liang, Shuling; Xu, Yang; Xu, Qianqian; Chen, Yuqiu; Zhao, Yan; Shao, Yuhao; Li, Huixin; Wang, Kexiong; Kong, Xiangang; Liu, Shengwang

    2015-12-31

    In this study, 418 IBVs were isolated in samples from 1717 chicken flocks. Twenty-nine of the isolates were classified as the Massachusetts genotype. These 29 isolates, as well as two previously isolated Massachusetts genotype IBV strains, were studied further. Of the 31 strains, 24 were H120-like and two were M41-like isolates as determined by complete genomic sequence analysis, indicating that most of the IBV isolates were likely the reisolated vaccine virus. The remaining five IBV isolates, ck/CH/LHB/111172, ck/CH/LSD/111219, ck/CH/LHB/130598, ck/CH/LDL/110931, and ck/CH/LHB/130573, were shown to have originated from natural recombination events between an H120-like vaccine strain and other types of viruses. The virus cross-neutralization test found that the antigenicity of ck/CH/LHB/111172, ck/CH/LSD/111219, and ck/CH/LHB/130598 was similar to that of H120. Vaccination with the H120 vaccine offered complete protection against challenge with these isolates. However, isolates ck/CH/LDL/110931 and ck/CH/LHB/130573 were serotypically different from their parental viruses and from other serotypes in this study. Furthermore, vaccination with the H120 vaccine did not provide protection against challenge with these two isolates. The results of this study demonstrated that recombination is the mechanism that is responsible for the emergence of new serotype strains, and it has the ability to alter virus serotypes. Therefore, IBV surveillance of chicken flocks vaccinated with IBV live vaccines, as well as the consideration of new strategies to effectively control IBV infection using inactivated or/and genetically engineered vaccines, is of great importance. PMID:26482289

  14. Contrasting geographical distribution of mortality from pneumoconiosis and chronic bronchitis and emphysema in British coal miners.

    OpenAIRE

    Coggon, D; Inskip, H.; Winter, P; Pannett, B

    1995-01-01

    To explore whether the characteristics of coal mine dust that predispose to chronic airways obstruction are the same as those associated with pneumoconiosis, mortality from the two disease was compared in coal miners in 22 counties of England and Wales during 1979-80 and 1982-90. The proportional mortality ratios (PMRs) for coal workers' pneumoconiosis varied from 135 (95% confidence interval (95% CI) 16-488) in Leicestershire to 3825 (95% CI 1538-7881) in South Glamorgan. The PMRs for chroni...

  15. Quantified pathology of emphysema, pneumoconiosis, and chronic bronchitis in coal workers

    OpenAIRE

    Leigh, J; Outhred, K G; McKenzie, H. I.; Glick, M; Wiles, A N

    1983-01-01

    ABSTRACT From a continuous series of 886 postmortem examinations on coal mine workers in New South Wales, Australia, from 1949 to 1982 and their histories the following data were obtained: age at death (886 cases), percentage of emphysema in both lungs (Heard method) (870 cases), bronchial gland wall (G-W) ratio (Reid Index) (412 cases), chest radiograph within 10 years of death (792 cases), history of work at the coal face (844 cases), history of amount of tobacco smoked (606 cases), and FEV...

  16. Infectious bronchitis virus S2 expressed from recombinant virus confers broad protection against challenge

    Science.gov (United States)

    We developed recombinant Newcastle disease virus (NDV) LaSota (rLS) expressing the IBV S2 gene (rLS/IBV.S2). The recombinant virus showed reduced pathogenicity compared to the parental LaSota strain but effectively elicited hemagglutination inhibition antibodies and protected chickens against lethal...

  17. Otras enfermedades obstructivas: bisinosis, bronquitis crónica y EPOC de origen laboral y bronquitis eosinofílica Other obstructive diseases: byssinosis, chronic bronchitis and occupational COPD and eosinophilic bronchitis

    OpenAIRE

    F. J. Michel De la Rosa; B. Fernández Infante

    2005-01-01

    Además del asma ocupacional y las enfermedades derivadas de la inhalación aguda, otras enfermedades obstructivas también reconocen un origen laboral. Aunque en la actualidad la bisinosis es una enfermedad rara en España, describimos las características de la misma por su interés histórico dentro de las enfermedades respiratorias de origen laboral y porque todavía sigue vigente en los países en vías de desarrollo. La bronquitis crónica también puede estar relacionada con la exposición laboral ...

  18. Cefditoren versus levofloxacin in patients with exacerbations of chronic bronchitis: serum inflammatory biomarkers, clinical efficacy, and microbiological eradication

    OpenAIRE

    Blasi F; Tarsia P; Mantero M; Morlacchi LC; Piffer F

    2013-01-01

    Francesco Blasi, Paolo Tarsia, Marco Mantero, Letizia C Morlacchi, Federico PifferDepartment of Pathophysiology and Transplantation, University of Milan, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Milan, ItalyBackground: The aim of this open-label, randomized, parallel-group pilot study was to evaluate the efficacy of cefditoren pivoxil and levofloxacin in terms of speed of reduction in inflammatory parameters, clinical recovery, and microbiological eradication.Metho...

  19. Serum levels of mannan-binding lectin in chickens prior to and during experimental infection with avian infectious bronchitis virus

    DEFF Research Database (Denmark)

    Juul-Madsen, H.R.; Munch, M.; Handberg, Kurt; Sørensen, P.; Johnson, A.A.; Norup, L.R.; Jørgensen, Poul Henrik

    2003-01-01

    Mannan-binding lectin (MBL) is a glycoprotein and a member of the C-type lectin super family, the collectin family, and the acute phase protein family. The MBL exerts its function by directly binding to microbial surfaces through its carbohydrate recognition domains, followed by direct opsonization...

  20. Clinical effectiveness and safety of gemifloxacin versus cefpodoxime in acute exacerbation of chronic bronchitis: A randomized, controlled trial

    Directory of Open Access Journals (Sweden)

    S Chatterjee

    2011-01-01

    Conclusion : The results of this randomized, single-blind trial demonstrated that a 7-day course of gemifloxacin is therapeutically comparable to cefpodoxime in terms of both clinical effectiveness and safety for the treatment of type II Anthonisen category AECB patients.

  1. The effect of choral music on emotions, immune parameters and lung function during physiotherapy treatment of pneumonia and bronchitis

    Directory of Open Access Journals (Sweden)

    F. H. Le Roux

    2007-02-01

    Full Text Available Introduction: Music, processed by the brain, has a strong impacton the emotions and health.  The Magnificat in D major of JS Bach communicates not only a positive emotion of happiness but also motivational behaviour. Infectious lung conditions are often associated with negative emotions which develop due to physiological changes. The hormonal action of the hypothalamuspituitary-adrenal axes (HPA could be negatively affected by emotions of anger and depression.  This will result in a disturbance of the mind-body inter-action.  Music therefore can exert a powerful influence on therapeutic benefits by changing the psychological status and the immune endocrine functions. The purpose of this study was to determine the effect of music, during respiratory physiotherapy treatment on a theemotional status, b neuroendocrine responses, c immune functions and d lung functions of subjects with infected lung conditions.Method and Materials: Forty subjects attending physiotherapy treatment was selected according to set criteria and randomly assigned to an experimental and control group. The parameters (Profile Of Mood State [POMS]; CD4:CD8 cell ratios; Cortisol; the Cortisol: DHEA ratio; PF; FEV1; FVC and FEV1/FVC % were measured on day 1before the treatment and on day 3 after the treatment.  Data were analysed with Statistica (Statsoft using the RepeatedANOVA tests. Results: Results indicated that the intervention of music had a positive effect on the immunological parameter (CD4+:CD8+ cell ratios and on the cortisol and cortisol:DHEA ratio levels.  At the same time the psychological  status as measured by Profile of Mood States (POMS scale improved with a significant improvement in the lung functions.Conclusion: The research provided sufficient scientific evidence that music affects both the biomedical and psycho-somatic aspects of infectious lung conditions.

  2. The effect of choral music on emotions, immune parameters and lung function during physiotherapy treatment of pneumonia and bronchitis

    OpenAIRE

    F. H. Le Roux; P. J. D. Bouic; R. Bester

    2007-01-01

    Introduction: Music, processed by the brain, has a strong impacton the emotions and health.  The Magnificat in D major of JS Bach communicates not only a positive emotion of happiness but also motivational behaviour. Infectious lung conditions are often associated with negative emotions which develop due to physiological changes. The hormonal action of the hypothalamuspituitary-adrenal axes (HPA) could be negatively affected by emotions of anger and depression.  This will result in a disturba...

  3. URBAN AIR PARTICULATE INHALATION ALTERS PULMONARY FUNCTION AND INDUCES PULMONARY INFLAMMATION IN A RODENT MODEL OF CHRONIC BRONCHITIS. (R825242)

    Science.gov (United States)

    The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

  4. Effect of infection route and concurrent infectious bronchitis virus vaccination on Mycoplasma gallisepticum disease pathology in an experimental model

    Science.gov (United States)

    The study of Mycoplasma gallisepticum infections is needed, not only to understand the disease process, but also to understand the mechanisms by which M. gallisepticum vaccines protect the host. Many model systems have been used to study the M. gallisepticum disease process. This work compared two...

  5. 21 CFR 520.2604 - Trimeprazine tartrate and prednisolone tablets.

    Science.gov (United States)

    2010-04-01

    ... “kennel cough” or tracheobronchitis, bronchitis including allergic bronchitis, in tonsillitis, acute upper... suffering from acute or chronic bacterial infections, provided the infection is controlled by...

  6. Chronic obstructive pulmonary disease

    Science.gov (United States)

    ... airways disease; Chronic obstructive lung disease; Chronic bronchitis; Emphysema; Bronchitis - chronic ... a protein called alpha-1 antitrypsin can develop emphysema. Other risk factors for COPD are: Exposure to ...

  7. Crosstalk between innate and adaptive immune responses to infectious bronchitis virus after vaccination and challenge of chickens varying in serum mannose-binding lectin concentrations

    DEFF Research Database (Denmark)

    Juul-Madsen, Helle R.; Norup, Liselotte R.; Jørgensen, Poul Henrik;

    2011-01-01

    . Serum MBL levels also influenced IBV vaccine-induced changes in circulating T-cell populations. Moreover, addition of mannose to an IBV vaccine altered both vaccine-induced changes in circulating T-cell populations and IBV specific vaccine and infection-induced antibody responses in chickens with high...... serum MBL levels. These data demonstrate that MBL is involved in the regulation of the adaptive immune response to IBV....

  8. Bronquite plástica em criança com talassemia alfa Plastic bronchitis in a child with thalassemia alpha

    OpenAIRE

    Tiago N. Veras; Gustavo M. Lannes; Jefferson P. Piva; Renato T. Stein; Marcus H. Jones; Vinicius D. Silva; Pedro Celiny R Garcia; Pitrez, Paulo M. C.

    2005-01-01

    OBJETIVO: A bronquite plástica é uma doença infreqüente na criança, sendo caracterizada por moldes ou cilindros mucofibrinosos na árvore traqueobrônquica. Faz parte do diagnóstico diferencial de crianças com insuficiência respiratória de início agudo, e o tratamento precoce é importante para a resolução do quadro. O objetivo deste relato é descrever um caso de bronquite plástica tratado com sucesso por endoscopia, em paciente portador de talassemia alfa. DESCRIÇÃO: Criança do sexo masculino, ...

  9. Homeopathic medicine for acute cough in upper respiratory tract infections and acute bronchitis: a randomized, double-blind, placebo-controlled trial.

    Science.gov (United States)

    Zanasi, Alessandro; Mazzolini, Massimiliano; Tursi, Francesco; Morselli-Labate, Antonio Maria; Paccapelo, Alexandro; Lecchi, Marzia

    2014-02-01

    Cough is a frequent symptom associated to upper respiratory tract infections (URTIs) and, although being self-limiting, it might deeply affect the quality of life. Homeopathic products are often employed by patients to treat cough, but the evidence on their efficacy is scarce. Thus, we tested the efficacy of a homeopathic syrup in treating cough arising from URTIs with a randomized, double blind, placebo controlled clinical trial. Patients were treated with either the homeopathic syrup or a placebo for a week, and recorded cough severity in a diary by means of a verbal category-descriptive score for two weeks. Sputum viscosity was assessed with a viscosimeter before and after 4 days of treatment; patients were also asked to provide a subjective evaluation of viscosity. Eighty patients were randomized to receive placebo (n = 40) or the homeopathic syrup (n = 40). All patients completed the study. In each group cough scores decreased over time, however, after 4 and 7 days of treatment, cough severity was significantly lower in the homeopathic group than in the placebo one (p syrup employed in the study was able to effectively reduce cough severity and sputum viscosity, thereby representing a valid remedy for the management of acute cough induced by URTIs. PMID:23714686

  10. RNA sequencing based analysis of the spleen transcriptome following the infectious bronchitis virus infection of chickens selected for different mannose-binding lectin serum concentrations

    DEFF Research Database (Denmark)

    Hamzic, Edin; Kjærup, Rikke Brødsgaard; Mach, Núria;

    2016-01-01

    . Conclusions Healthy animals from the two lines showed significant differences in expression profiles for subsets of both adaptive and innate immunity related genes. Whereas, comparison of the IBV infected birds from the two MBL lines showed differences in expression of immunity related genes involved in T....... Sixteen birds from each line were infected with IBV on day 1 and birds were euthanized at 1 week and 3 weeks post infection, 8 uninfected controls and 8 infected birds from each line at each occasion. RNA sequencing was performed on spleen samples from all 64 birds used in the experiment. Differential...... performed using Gene Ontology (GO) Immune System Process terms specific for Gallus gallus. Results Comparing uninfected L10H and L10L birds, we identified 1698 and 1934 differentially expressed (DE) genes at week 1 and week 3, respectively. For the IBV infected birds 1698 and 1934 DE genes were identified...

  11. An intervention with access to C-reactive protein rapid test reduces antibiotic overprescribing in acute exacerbations of chronic bronchitis and COPD

    DEFF Research Database (Denmark)

    F. Strykowski, David; Nielsen, Anni Brit Sternhagen; Llor, Carles;

    2015-01-01

    Background. In acute exacerbation of chronic obstructive pulmonary disease (AECOPD) antibiotic overprescribing leads to antimicrobial resistance and underprescribing may cause poor patient outcomes. Objective. This study aimed to evaluate changes in over- and underprescribing of antibiotics after...

  12. The classification of avian infectious bronchitis field isolates in Henan province%河南IBV肾变型地方分离株的分型研究

    Institute of Scientific and Technical Information of China (English)

    王泽霖; 王宪文; 席瑞珍; 李建丽; 李华民

    2004-01-01

    在气管环上进行交叉中和试验,结果显示河南分离的肾变型宜毒株与除T株以外的其余标准血清型毒株(M41、Holte、Arka、Conn、Gray)均有不同程度的交叉,但与Ark株相关性最大,为25%.将除Holte株以外的5株标准株和宜株的0.6kb扩增产物,用三种限制性内切酶AluⅠ、TaqⅠ和AfaⅠ进行酶切,RFLP分析可分为三种模式,宜株与Ark株、Gray株、CoNn株属同一模式,AluⅠ和AfaⅠ酶切阳性而TaqⅠ酶切阴性.另AluⅠ、TaqⅠ、AfaⅠ酶切均阳性的M41模式和TaqⅠ、AfaⅠ酶切阳性而AluⅠ酶切阴性的T株模式.将地方株宜株的0.6kb扩增片段进行测序并与标准株Ark株、Gray株、Conn株、Holte株和M41株的相应序列进行分析比较,核苷酸、氨基酸同源性的分析显示,宜毒株与同一酶切类型的Ark-1529-29株同源性最高,核苷酸同源性为93%,氨基酸同源性为91.6%.推测宜株可能是Ark血清型毒株的变异株.宜株与Ark株在血清学分型与基因分型上的一致性,表明这两种分型方法之间有一定的内在联系.

  13. Intake of high fructose corn syrup sweetened soft drinks is associated with prevalent chronic bronchitis in U.S. Adults, ages 20–55 y

    OpenAIRE

    DeChristopher, Luanne Robalo; URIBARRI, JAIME; Tucker, Katherine L.

    2015-01-01

    Background High fructose corn syrup (HFCS) sweetened soft drink intake has been linked with asthma in US high-schoolers. Intake of beverages with excess free fructose (EFF), including apple juice, and HFCS sweetened fruit drinks and soft drinks, has been associated with asthma in children. One hypothesis for this association is that underlying fructose malabsorption and fructose reactivity in the GI may contribute to in situ formation of enFruAGEs. EnFruAGEs may be an overlooked source of adv...

  14. Productive replication of nephropathogenic infectious bronchitis virus in peripheral blood monocytic cells, a strategy for viral dissemination and kidney infection in chickens.

    Science.gov (United States)

    Reddy, Vishwanatha R A P; Trus, Ivan; Desmarets, Lowiese M B; Li, Yewei; Theuns, Sebastiaan; Nauwynck, Hans J

    2016-01-01

    In the present study, the replication kinetics of nephropathogenic (B1648) and respiratory (Massachusetts-M41) IBV strains were compared in vitro in respiratory mucosa explants and blood monocytes (KUL01(+) cells), and in vivo in chickens to understand why some IBV strains have a kidney tropism. B1648 was replicating somewhat better than M41 in the epithelium of the respiratory mucosa explants and used more KUL01(+) cells to penetrate the deeper layers of the respiratory tract. B1648 was productively replicating in KUL01(+) monocytic cells in contrast with M41. In B1648 inoculated animals, 10(2.7-6.8) viral RNA copies/100 mg were detected in tracheal secretions at 2, 4, 6, 8, 10 and 12 days post inoculation (dpi), 10(2.4-4.5) viral RNA copies/mL in plasma at 2, 4, 6, 8, 10 and 12 dpi and 10(1.8-4.4) viral RNA copies/10(6) mononuclear cells in blood at 2, 4, 6 and 8 dpi. In M41 inoculated animals, 10(2.6-7.0) viral RNA copies/100 mg were detected in tracheal secretions at 2, 4, 6, 8 and 10 dpi, but viral RNA was not demonstrated in plasma and mononuclear cells (except in one chicken at 6 dpi). Infectious virus was detected only in plasma and mononuclear cells of the B1648 group. At euthanasia (12 dpi), viral RNA and antigen positive cells were detected in lungs, liver, spleen and kidneys of only the B1648 group and in tracheas of both the B1648 and M41 group. In conclusion, only B1648 can easily disseminate to internal organs via a cell-free and -associated viremia with KUL01(+) cells as important carrier cells. PMID:27412035

  15. Parental and household smoking and the increased risk of bronchitis, bronchiolitis and other lower respiratory infections in infancy: systematic review and meta-analysis

    Directory of Open Access Journals (Sweden)

    Britton John

    2011-01-01

    Full Text Available Abstract Background Passive smoke exposure increases the risk of lower respiratory infection (LRI in infants, but the extensive literature on this association has not been systematically reviewed for nearly ten years. The aim of this paper is to provide an updated systematic review and meta-analysis of studies of the association between passive smoking and LRI, and with diagnostic subcategories including bronchiolitis, in infants aged two years and under. Methods We searched MEDLINE and EMBASE (to November 2010, reference lists from publications and abstracts from major conference proceedings to identify all relevant publications. Random effect pooled odds ratios (OR with 95% confidence intervals (CI were estimated. Results We identified 60 studies suitable for inclusion in the meta-analysis. Smoking by either parent or other household members significantly increased the risk of LRI; odds ratios (OR were 1.22 (95% CI 1.10 to 1.35 for paternal smoking, 1.62 (95% CI 1.38 to 1.89 if both parents smoked, and 1.54 (95% CI 1.40 to 1.69 for any household member smoking. Pre-natal maternal smoking (OR 1.24, 95% CI 1.11 to 1.38 had a weaker effect than post-natal smoking (OR 1.58, 95% CI 1.45 to 1.73. The strongest effect was on bronchiolitis, where the risk of any household smoking was increased by an OR of 2.51 (95% CI 1.96 to 3.21. Conclusions Passive smoking in the family home is a major influence on the risk of LRI in infants, and especially on bronchiolitis. Risk is particularly strong in relation to post-natal maternal smoking. Strategies to prevent passive smoke exposure in young children are an urgent public and child health priority.

  16. Emergence of a coronavirus infectious bronchitis virus mutant with a truncated 3b gene: functional characterization of the 3b protein in pathogenesis and replication

    International Nuclear Information System (INIS)

    The subgenomic RNA 3 of IBV has been shown to be a tricistronic mRNA, encoding three products in IBV-infected cells. To explore if the least expressed ORF, ORF 3b, which encodes a nonstructural protein, is evolutionarily conserved and functionally indispensable for viral propagation in cultured cells, the Beaudette strain of IBV was propagated in chicken embryonated eggs for three passages and then adapted to a monkey kidney cell line, Vero. The 3b gene of passage 3 in embryonated eggs and passages 7, 15, 20, 25, 30, 35 50, and 65 in Vero cells were amplified by reverse transcription-polymerase chain reaction and sequenced. The results showed that viral RNA extracted from passages 35, 50, and 65 contained a single A insertion in a 6A stretch of the 3b gene between nucleotides 24075 and 24080, whereas the early passages carried the normal 3b gene. This insertion resulted in a frameshift event and therefore, if expressed, a C-terminally truncated protein. We showed that the frameshifting product, cloned in a plasmid, was expressed in vitro and in cells transfected with the mutant construct. The normal product of the 3b gene is 64 amino acids long, whereas the frameshifting product is 34 amino acids long with only 17 homogeneous amino acid residues at the N-terminal half. Immunofluorescent studies revealed that the normal 3b protein was localized to the nucleus and the truncated product showed a 'free' distribution pattern, indicating that the C-terminal portion of 3b was responsible for its nuclear localization. Comparison of the complete genome sequences (27.6 kb) of isolates p20c22 and p36c12 (from passages 20 and 36, respectively) revealed that p36c12 contains three amino acid substitutions, two in the 195-kDa protein (encoded by gene 1) and one in the S protein, in addition to the frameshifting 3b product. Further characterization of the two isolates demonstrated that p36c12 showed growth advantage over p20c22 in both Vero cells and chicken embryos and was more virulent in chicken embryos than p20c22. These results suggest that the 3b gene product is not essential for the replication of IBV

  17. EFFECTS OF EXPOSURE TO CONCENTRATED AMBIENT PARTICLES FROM DETROIT AIR ON HEALTHY RATS AND RATS WITH FEATURES OF ASTHMA OR MILD BRONCHITIS

    Science.gov (United States)

    Investigators will conduct  a 2-year study with rats to evaluate the short-term effects of inhaling concentrated ambient particles derived from the air in an area of Detroit, Michigan that has a high incidence of childhood asthma. The investigators will use two animal ...

  18. Karakteristik Penderita Bronkitis Yang Dirawat Jalan Pada Kelompok Umur > 15 Tahun Di RSU Dr. Ferdinand Lumban Tobing Sibolga Tahun 2010 - 2012

    OpenAIRE

    Simanjuntak, Rinaldi Togap

    2014-01-01

    Bronchitis (Inflamation bronchi) is described as inflammation of the bronchial vessels. It is characterized by inflammation of the bronchial tubes and divided into acute and chronic forms. Indonesia does not have accurate data on morbidity of acute or chronic bronchitis. Bronchitis including ten biggest disease in the outpatient Dr. Ferdinan L. Tobing General Hospital. Total cases of bronchitis in 2010-2012 there were 442 cases. To determine the characteristics of patients with bronchitis ...

  19. Breath sounds

    Science.gov (United States)

    Causes of abnormal breath sounds may include: Acute bronchitis Asthma Bronchiectasis Chronic bronchitis Congestive heart failure Emphysema Interstitial lung disease Foreign body obstruction of the airway Pneumonia Pulmonary edema Tracheobronchitis

  20. Pulmonary function tests

    Science.gov (United States)

    ... of lung disease, such as asthma , bronchitis , and emphysema Find the cause of shortness of breath Measure ... or lung disease. Some lung diseases (such as emphysema, asthma, chronic bronchitis, and infections) can make the ...

  1. Dicty_cDB: Contig-U11901-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available M41, complete ... 46 5.0 1 ( AY851295 ) Avian infectious bronchitis virus strain ...Mass 41,... 46 5.0 1 ( AY641576 ) Avian infectious bronchitis virus isolate Peafowl... 46 5.0 1 ( AY514485 )

  2. Disease: H01083 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available 73090 (description, env_factor) Meis JF, van Griethuijsen AJ, Muytjens HL Bordetella bronchiseptica bronchitis...env_factor) Papasian CJ, Downs NJ, Talley RL, Romberger DJ, Hodges GR Bordetella bronchiseptica bronchitis

  3. Clinical Practice Guidelines for Severe Chronic Obstructive Pulmonary Disease. Guía de práctica clínica para el tratamiento de la enfermedad pulmonar obstructiva crónica grave.

    OpenAIRE

    Inti Santana Carballosa; Alexis Díaz Mesa; Carlos Alberto Martell Alonso; Diosdania Alfonso Falcón; Niurka Mercedes Galende Hernández

    2009-01-01

    Clinical Practice Guidelines for Severe Chronic Obstructive Pulmonary Disease. This concept includes simple chronic bronchitis, asthmatic bronchitis, chronic obstructive bronchitis, and pulmonary emphysema; although this two last are the most commonly included. Risk factors, classification and treatment are commented, stressing the strategy of mechanical ventilation and the indications for mechanical invasive and no invasive ventilation. It includes assessment guidelines focused on the most i...

  4. Clinical Practice Guidelines for Severe Chronic Obstructive Pulmonary Disease.

    OpenAIRE

    Niurka Mercedes Galende Hernández; Diosdania Alfonso Falcón; Carlos Alberto Martell Alonso; Alexis Díaz Mesa; Inti Santana Carballosa

    2009-01-01

    Clinical Practice Guidelines for Severe Chronic Obstructive Pulmonary Disease. This concept includes simple chronic bronchitis, asthmatic bronchitis, chronic obstructive bronchitis, and pulmonary emphysema; although this two last are the most commonly included. Risk factors, classification and treatment are commented, stressing the strategy of mechanical ventilation and the indications for mechanical invasive and no invasive ventilation. It includes assessment guidelines focused on the most i...

  5. Banxia Zhike Syrup in Treating Cough of Infantile Acute Bronchitis for 40 Cases%半夏止咳糖浆治疗小儿急性支气管炎咳嗽40例

    Institute of Scientific and Technical Information of China (English)

    李君

    2015-01-01

    目的 本研究旨在观察半夏止咳糖浆对小儿急性支气管炎(风寒型咳嗽)的临床疗效.方法 收集符合入组标准的急性支气管炎(风寒型)患者80例,随机分为对照组和治疗组各40例,治疗组给予半夏止咳糖浆口服,对照组给予风寒咳嗽颗粒口服,分别观察两组患儿在用药后3天的临床疗效.结果 治疗后两组总体疗效比较,差异具有统计学意义(P<0.05).结论 ①半夏止咳糖浆治疗小儿风寒型咳嗽优于风寒咳嗽颗粒;②半夏止咳糖浆具有疏风散寒、宣肺止咳化痰的作用.

  6. 愈美颗粒辅助治疗小儿急性支气管炎的疗效观察%Efficacy of Guaifenesin and Dextromethorphan Hydrobromide Granules in the Adjuvant Treatment of Infantile Acute Bronchitis

    Institute of Scientific and Technical Information of China (English)

    褚珺琼; 戴桂芬

    2014-01-01

    目的:观察愈美颗粒治疗小儿急性支气管炎的临床疗效及安全性.方法:156例急性支气管炎患儿随机分为两组,对照组予常规抗感染及雾化吸入等治疗,观察组加用愈美颗粒治疗.比较两组患儿咳嗽、咳痰和痰液黏稠度等临床症状改善率和总有效率,并观察药品不良反应.结果:观察组治疗后临床症状评分显著优于对照组(P<0.05).观察组临床控制率52.56%,总有效率89.74%,均明显高于对照组(P<0.05),且未发生明显药品不良反应.结论:愈美颗粒能有效辅助治疗小儿急性支气管炎,安全性好,值得临床推广使用.

  7. Use Thread Embedding in Tanzhong Point to Treat 35 Cases of Acute and Chronic Bronchitis%膻中穴埋线治疗急慢性支气管炎35例

    Institute of Scientific and Technical Information of China (English)

    王尚威

    2001-01-01

    @@ 笔者近几年来运用中医的整体观念和辨证论治的原则,采用内病外治的方法,用健康猪躯干毛发行膻中穴穴位埋线,治疗急慢性支气管炎,收到很好的疗效,现报告如下.

  8. High-dose oral N-acetylcysteine fails to improve respiratory health status in patients with chronic obstructive pulmonary disease and chronic bronchitis: a randomized, placebo-controlled trial

    OpenAIRE

    Johnson K; McEvoy CE; Naqvi S.; Wendt C; Reilkoff RA; Kunisaki KM; Wetherbee EE; Nelson D; Tirouvanziam R; Niewoehner DE

    2016-01-01

    Kara Johnson,1,2 Charlene E McEvoy,3 Sakina Naqvi,1,4 Chris Wendt,1 Ronald A Reilkoff,4,5 Ken M Kunisaki,1 Erin E Wetherbee,1 David Nelson,6 Rabindra Tirouvanziam,7 Dennis E Niewoehner1 1Pulmonary Section, Minneapolis VA Health Care System, Minneapolis, MN, 2Sanford Health, Fargo, ND, 3Pulmonary Section, HealthPartners Research Foundation, St Paul, 4HealthEast Maplewood Clinic, Maplewood, 5Pulmonary Section, University of Minnesota Medical Center, 6Center for Chronic Disease Outcomes Researc...

  9. The effect of Inhalation Terbutaline Sulphate in Treatment Patients with chronic Asthmatic Bronchitis%硫酸特布他林雾化吸入治疗慢性喘息性支气管炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    杨珺楠; 向平超; 张二明

    2005-01-01

    目的观察硫酸特布他林雾化吸入治疗慢性喘息性支气管炎的临床效果.方法将46例慢性喘息性支气管炎的患者随机分成两组,硫酸特布他林组治疗组26例,生理盐水对照组20例,分别给予硫酸特布他林0.25mg加入0.9%生理盐水4ml雾化吸入,对照组为0.9%生理水4ml雾化吸入.雾化前后分别观察患者喘憋症状、肺部干罗音、心率、血气(PaO2、PaCO2、PH)和肺功能FEV1.0、PVC、PEF.结果硫酸特布他林雾化吸入对慢性喘息性支气管炎临床症状和体征有明显改善,血氧分压由62.73mmHg提高到73.3mmHg.肺功能FEV1.0、FVC、PEF明显改善,治疗组明显优于对照组,且副作用小.结论硫酸特布他林雾化吸入能有效缓解支气管痉挛,改善患者的临床症状,及通气功能.

  10. Efecto del tiempo de exposición a PM10 en las urgencias por bronquitis aguda Effect of exposure time to PM10 on emergency admissions for acute bronchitis

    OpenAIRE

    Franz Muñoz; Marilia Sá Carvalho

    2009-01-01

    Este trabajo analiza el efecto de las horas de exposición a PM10 en las urgencias diarias por bronquitis aguda, controlando por temperatura y humedad. El estudio fue realizado en seis sectores de la ciudad de Santiago, Chile, durante el período de invierno de los años 2002 al 2004, para lactantes ( 65 años). Analizamos el retraso de la respuesta mediante una función polinomial distributiva (pdl), incluida en un modelo lineal generalizado (GLM-pdl), y la estructura...

  11. Clinical observation of chronic bronchitis treated with application therapy during the hottest and coldest days of the year%“伏九贴敷疗法”治疗慢性支气管炎的临床观察

    Institute of Scientific and Technical Information of China (English)

    赵欲晓

    2010-01-01

    @@ Application therapy during the hottest and coldest days of the year is a kind of external therapy of Chinese medicine in which a specifically-prepared Chinese herbal plaster is applied on the specific points of human body during the three ten-day periods of the hottest days in summer, from mid-July to mid-August,and the three nine-day periods after the winter solstice,reputed to be the coldest days of the year, including two sessions of treatment, named the treatment in summer for disorder in winter and prevention in winter for disorder in winter.

  12. Kortisontherapie bei der chronisch-obstruktiven Bronchitis(2)%慢性阻塞性支气管炎的可的松治疗(2)(反对应用激素治疗COPD的观点)

    Institute of Scientific and Technical Information of China (English)

    Gilli.,A; 高亚东

    2000-01-01

    @@ COPD激素治疗的逻辑 根据病理生理基础和支气管哮喘对激素的良好反应,人们认为,吸入激素治疗可阻止肺功能的进一步恶化,且在提高生活质量的同时降低了恶化率和死亡率,因而数年来国际国内推荐COPD的激素治疗.

  13. X-ray morphofunctional changes in the bronchopulmonary system of workers engaged in ethylene oxide production and processing

    International Nuclear Information System (INIS)

    A total of 3475 workers engaged in ethyleneoxide production for 2-20 years, were examined by clinical and x-ray methods. X-ray examinations included roentgenomorphologic (total fluorography of the thoracic cavity organs and long-distance roentgenofunctional methods of examination of the bronchopulmonary system. Chronic bronchitis was detected in 407 workers in 76.2 % of it was chronic nonobstructive functionally unstable bronchitis, in the rest it was chronic obstructive bronchitis

  14. Using oxygen at home

    Science.gov (United States)

    Oxygen - home use; COPD - home oxygen; Chronic obstructive airways disease - home oxygen; Chronic obstructive lung disease - home oxygen; Chronic bronchitis - home oxygen; Emphysema - home oxygen; Chronic respiratory ...

  15. 38 CFR 3.316 - Claims based on chronic effects of exposure to mustard gas and Lewisite.

    Science.gov (United States)

    2010-07-01

    ..., bronchitis, emphysema, asthma or chronic obstructive pulmonary disease. (3) Full-body exposure to nitrogen mustard during active military service together with the subsequent development of acute...

  16. Dicty_cDB: FC-AV08 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 4e-42 AY338732_1( AY338732 |pid:none) Avian infectious bronchitis virus ... 34 1.4 EU637854_1( EU637854 |pi... Z30541 |pid:none) Avian infectious bronchitis virus mRNA... 33 3.1 AY319651_1( A...Y319651 |pid:none) Avian infectious bronchitis virus ... 33 3.1 FJ807652_2( FJ807652 |pid:none) Infectious b...1( AY641576 |pid:none) Avian infectious bronchitis virus ... 33 3.1 protein updat

  17. 21 CFR 522.820 - Erythromycin.

    Science.gov (United States)

    2010-04-01

    ..., bronchitis, tracheitis, pharyngitis, pleurisy), endometritis and metritis, and bacterial wound infections... injection once daily for up to 5 days. (ii) Indications for use. For the treatment of bovine...

  18. Convergence of the epidemiology and pathology of COPD

    DEFF Research Database (Denmark)

    Vestbo, Jørgen; Hogg, J C

    2006-01-01

    The epidemiology of chronic obstructive pulmonary disease (COPD) has been dominated by one hypothesis stating that cigarette smoking and chronic bronchitis were the key to pathogenesis and another that asthma, chronic bronchitis, and even emphysema are related to different expressions of a primary...... airway abnormality. The first hypothesis was rejected in the late 1960s based on a longitudinal study of working men where only a fraction of smokers developed COPD and where development of COPD was independent of the absence or presence of chronic bronchitis. Chronic bronchitis in more advanced COPD was...

  19. Dicty_cDB: Contig-U15613-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available itis virus isolat... 50 2e-04 DQ059619_1( DQ059619 |pid:none) Infectious bronchitis... virus isolat... 48 0.001 DQ059620_1( DQ059620 |pid:none) Infectious bronchitis virus isolat... 48 0.001 FJ2...35194_1( FJ235194 |pid:none) Infectious bronchitis virus isolat... 47 0.002 CP000...191_1( FJ235191 |pid:none) Infectious bronchitis virus isolate V1/07 spike protei...Sequences producing significant alignments: (bits) Value FJ235191_1( FJ235191 |pid:none) Infectious bronch

  20. 21 CFR 520.2605 - Trimeprazine tartrate and prednisolone capsules.

    Science.gov (United States)

    2010-04-01

    ... various cough conditions including treatment of “kennel cough” or tracheobronchitis, bronchitis including allergic bronchitis, tonsillitis, acute upper respiratory infections, and coughs of nonspecific origin. The product may also be administered to dogs suffering from acute or chronic bacterial infections,...

  1. Disease: H00351 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available acteria that causes human respiratory infections. Repeated or prolonged exposure to Cp. pneumoniae is associated with asthma...tic bronchitis and asthma, and chronic infection can contribute to the development of adult-onset asthma...ov R Association of Chlamydia pneumoniae (strain TWAR) infection with wheezing, asthmatic bronchitis, and adult-onset asthma. JAMA 266:225-30 (1991) ...

  2. AcEST: DK944231 [AcEST

    Lifescience Database Archive (English)

    Full Text Available efinition sp|P12650|SPIKE_IBVK Spike glycoprotein OS=Avian infectious bronchitis virus (strain KB8523) Align...significant alignments: (bits) Value sp|P12650|SPIKE_IBVK Spike glycoprotein OS=Avian infectious bron... 32 ...1.3 >sp|P12650|SPIKE_IBVK Spike glycoprotein OS=Avian infectious bronchitis virus

  3. Dicty_cDB: Contig-U05008-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available id:none) Plasmodium falciparum clone SD105 ... 33 5.0 DQ490219_1( DQ490219 |pid:none) Infectious bronchiti... J, comp... 33 6.5 DQ490220_1( DQ490220 |pid:none) Infectious bronchitis virus strain... 33 6.5 AM902716_422

  4. AcEST: BP916098 [AcEST

    Lifescience Database Archive (English)

    Full Text Available VA-------KQNIQKQLASIKQQKQ 290 >tr|Q7T835|Q7T835_9CORO Replicase polyprotein 1ab OS=Infectious bronchitis...YMLFLILFVKPVAGFVIICYCIRYLVLS 1884 >tr|Q7T834|Q7T834_9CORO Replicase polyprotein 1a OS=Infectious bronchitis

  5. Dicty_cDB: FC-AS05 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available cterized transmembrane protein DDB... 305 8e-82 AY338732_1( AY338732 |pid:none) Avian infectious bronchitis ...virus ... 34 4.6 EU637854_1( EU637854 |pid:none) Infectious bronchitis virus strain... 34 6.0 CP001055_1360(

  6. Bronchography in patients with persistent cough

    International Nuclear Information System (INIS)

    Bronchography was performed together with a fibre-optic bronchoscopic study in 98 patients with persistent cough, 33 of whom also had haemoptysis. Finally there were chronic bronchitis in 62 patients, bronchiectasis in 21, subacute bronchitis in 9, inflammatory residuals in 3, pulmonary tuberculosis in 2 patients and metastases in one. In chronic bronchitis, the value of plain chest radiography was low. It was normal in 34 of 62 cases (55%), bronchography in 12 cases (19%). Mild cases of bronchitis were more numerous in bronchography than seen by scopist. Bronchiectasis was found in 21 patients, four of these unexpectedly (two in a tbc scar). Additionally, three cases were overdiagnosed by the radiologist on chest films and eight cases by the scopist with bronchoscopy. In patients with persistent cough and haemoptysis, bronchography mainly revealed alterations of bronchitis. (orig.)

  7. Dicty_cDB: Contig-U08402-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available iparum 3D7 chromo... 35 5.3 Z30541_1( Z30541 |pid:none) Avian infectious bronchitis virus mRNA... 35 5.3 AY3...19651_1( AY319651 |pid:none) Avian infectious bronchitis virus ... 35 5.3 AL844505_76( AL844505 |pid:none) P...rotein 1ab; Short... 35 5.3 AY646283_1( AY646283 |pid:none) Avian infectious bronchitis virus ... 35 5.3 M94...356_3( M94356 |pid:none) Avian infectious bronchitis virus ORF1... 35 5.3 AY692454_2( AY692454 |pid:none) Avian infectious... bronchitis virus ... 35 5.3 DQ001339_2( DQ001339 |pid:none) Avian infectious

  8. Control effect of "Jingfang Baidu San" liquid formulation on chicken mixed infection by infectious bronchitis and coryza%"荆防败毒散"液剂防治鸡传染性支气管炎与传染性鼻炎混合感染的效果

    Institute of Scientific and Technical Information of China (English)

    许秋菊; 贾庆利; 骆延波; 赵会超; 白福翥

    2008-01-01

    本试验分别以15、10、5 ml/kg饮水为高、中、低剂量,以25 ml/kg饮水添加剂量为安全剂量方式添加中兽药"荆防败毒散"液剂,以15 g/kg饲料的剂量拌料添加"荆防败毒散"散剂为药物对照,治疗海兰褐公雏传染性支气管炎与鼻炎人工混合感染.结果表明,中兽药"荆防败毒散"液剂高、中、低剂量组临床治疗效果(有效率分别为98%、96%、90%)高于对照药物组(有效率为86%).本品临床治疗鸡传染性支气管炎与传染性鼻炎混合感染时推荐剂量为5 ml/kg饮水,自由采食,连用5天.

  9. 应用三重聚合酶链反应同时检测鉴别鸡3种病毒性呼吸道传染病的研究%Studies on the Detection of Newcastle Diseases Virus, Infectious Bronchitis Virus and Infectious Laryngotracheitis Virus by Triplex PCR

    Institute of Scientific and Technical Information of China (English)

    谢芝勋; 谢志勤; 庞耀珊; 刘加波; 邓显文; 廖敏

    2001-01-01

    根据鸡新城疫病毒(NDV)、鸡传染性支气管炎病毒(IBV)和鸡传染性喉气管炎病毒(ILTV)的基因文库,设计了3对分别与NDV、IBV和ILTV某段基因序列互补的引物.用这3对引物对同一样品中的NDV、IBV、ILTV核酸模板进行三重PCR扩增,结果均同时得到了3条与设计相符的310 bp(NDV)、1720 bp(IBV)和647 bp(ILTV)三重PCR扩增带,而对其他6种禽病病原的PCR扩增结果均为阴性;敏感性测定结果表明,该三重PCR技术能检出10pg的IBV、1pg的NDV RNA模板和10 pg的ILTV DNA模板.

  10. Observation on curative effect and safety of combined therapy of Budesonide, Terbutaline Sulphate and Ipratropium Bromide for children with asthmatic bronchitis%布地奈德、硫酸特布他林、异丙托溴铵气雾剂联合雾化吸入治疗小儿喘息性支气管炎的效果观察

    Institute of Scientific and Technical Information of China (English)

    刘华容

    2014-01-01

    目的 观察临床联合运用布地奈德、硫酸特布他林、异丙托溴铵气雾剂吸入治疗小儿喘息性支气管炎的效果及安全性.方法 选择喘息性支气管炎患儿216例,随机分为观察组108例,对照组108例,两组均使用相同的抗感染、止咳平喘、吸氧等治疗.观察组加吸人用布地奈德混悬液、硫酸特布他林雾化液、异丙托溴铵气雾剂联合雾化吸入.对照组则使用地塞米松、α-糜蛋白酶雾化吸人.对两组的症状及体征得到明显改善的时间、总有效率及不良反应发生率进行比较.结果 观察组在临床症状咳嗽以及喘息上明显改善的时间及肺部体征消失时间均较对照组短,差异有统计学意义[咳嗽:(4.32±1.41)d比(7.81±1.20)d,t=10.547,P=0.007;喘息:(3.15±0.92)d比(5.23±1.21)d,t=9.973,P=0.008;肺部体征:(3.47±1.12)d比(7.05±1.31)d,t=10.182,P=0.008];观察组总有效率为95.4%,对照组为78.7%,两组比较,差异有统计学意义(x2=13.295,P=0.000);观察组不良反应发生率为1.85%,对照组为2.78%,差异无统计学意义(x2=0.030,P=0.978).结论 联合运用布地奈德、硫酸特布他林、异丙托溴铵气雾剂经压力雾化泵吸入治疗小儿喘息性支气管炎效果显著,且无明显不良反应,值得临床推广应用.

  11. Distribución y persistencia de tres cepas de virus bronquitis infecciosa (VBI) en tejidos de pollos libres de patógenos específicos (SPF) Distribution and persistence of three strains infectious bronchitis virus (VBI) in tissues of specific pathogen free chicks

    OpenAIRE

    Ulloa, J.; Schwartz, M; Pino, A.; G Jara

    2002-01-01

    Se estudió la distribución y persistencia de tres cepas de campo de virus Bronquitis infecciosa (Austral 3, 5 y 14), en tejidos de pollos libres de patógenos específicos, infectados experimentalmente. Para determinar la distribución, se utilizaron tres grupos de 30 pollos cada uno, de 2 semanas de edad, inoculados por instilación ocular y nasal con 10(4) DIE50/0.1 ml de cada una de las cepas en estudio. Previo y posterior a la infección (cada 8 horas hasta el segundo día y cada 12 horas hasta...

  12. Distribución y persistencia de tres cepas de virus bronquitis infecciosa (VBI en tejidos de pollos libres de patógenos específicos (SPF Distribution and persistence of three strains infectious bronchitis virus (VBI in tissues of specific pathogen free chicks

    Directory of Open Access Journals (Sweden)

    J ULLOA

    2002-01-01

    Full Text Available Se estudió la distribución y persistencia de tres cepas de campo de virus Bronquitis infecciosa (Austral 3, 5 y 14, en tejidos de pollos libres de patógenos específicos, infectados experimentalmente. Para determinar la distribución, se utilizaron tres grupos de 30 pollos cada uno, de 2 semanas de edad, inoculados por instilación ocular y nasal con 10(4 DIE50/0.1 ml de cada una de las cepas en estudio. Previo y posterior a la infección (cada 8 horas hasta el segundo día y cada 12 horas hasta el cuarto día, se sacrificaron 3 pollos por grupo, recolectándose tráquea, pulmón, proventrículo, vesícula biliar, intestino delgado, intestino grueso, riñones, timo y bolsa de Fabricio. En cada uno de los muestreos, tejidos iguales se agruparon y homogeneizaron, adicionándose posteriormente PBS con antibióticos, en una relación 5% peso/ volumen. La recuperación de las cepas se realizó en huevos embrionados SPF y anillos traqueales, expresándose los resultados en índices de aislamiento. El estudio de persistencia en tejidos se realizó en tres grupos de 21 pollos cada uno, de 2 semanas de edad. Cada grupo fue infectado, mediante instilación ocular, nasal y traqueal, con 10(5 DIE50/0.1 ml de la suspensión viral. Transcurridos 7, 12, 19, 26, 33, 40 y 47 días de la infección, de cada grupo se obtuvieron muestras de tráquea, pulmón, proventrículo, intestino delgado, intestino grueso y riñones, intentándose el aislamiento de las cepas en huevos embrionados y anillos traqueales. En la primera experiencia, considerando el período total de observación, las cepas se recuperaron en ambos sustratos biológicos, de los 9 tejidos examinados. Sin embargo, éstas no se recuperaron en el 100% de las muestras. Los mayores índices de aislamientos se registraron de las suspensiones de tráquea, pulmón, proventrículo, riñón e intestino grueso. En algunos tejidos, la frecuencia de aislamientos de las cepas en un primer pasaje fue mayor en anillos traqueales, indicando una mayor sensibilidad de este sustrato. Con relación a la persistencia de las cepas en tejidos, no se presentaron grandes diferencias, observándose una mayor permanencia en intestino grueso y riñones (19 y 47 días respectivamenteThe distribution and persistence of three field strains of the IB virus (Austral 3, 5 and 14, on experimentally inoculated SPF chicken was studied. In order to determine its distribution, three groups of 30 chicks that were each two-weeks old, were inoculated by ocular and nasal instillation with 10(4 EID 50/0.1 ml of each strain. Three chicks of each group were slaughtered before and after the infection (every 8 hours until the second day post infection and every 12 hours until the fourth day, collecting samples of trachea, lung, proventriculus, gall bladder, small intestine, large intestine, kidney, thymus and Fabricius bursa. On every sampling, tissues of the same kind were grouped and homogenized, later, PBS with antibiotic was added in a 5% weight/volume relationship. The recovery of the strains were performed on SPF embryonated eggs and tracheal rings, and their results were expressed as isolation index. The study of persistence of the virus in tissues was performed in three groups of 21 chicks that were each two-weeks old. Every group was infected with 10(5 EID 50/0.1 ml of viral suspension through ocular, nasal and tracheal instillation on days 7, 12, 19, 26, 33, 40 and 47. After the inoculation tracheal, lung, proventriculus, small intestine, large intestine and kidneys samples were collected, and its isolation on embryonated eggs and tracheal rings was initiated. On the first trial, the strains were recovered from both biological substratum of the nine tissues examined throughout the whole experiment; although they were not recovered from 100% of the samples. The largest isolation indexes were obtained from the tracheal suspension, lung, proventriculus, kidney and large intestine. In some tissues the frecuency of isolations of the strains in the first passage was higher in the tracheal rings. There were no major differences in the persistence of the strains on the different tissues, only a longer permanence on the large intestine and kidneys was observed (19 and 47 days respectively

  13. Detección y caracterización del virus de bronquitis infecciosa aviaria en Chile mediante RT-PCR y análisis secuencial Detection and characterization of infectious bronchitis virus in Chile by RT-PCR and sequence analysis

    OpenAIRE

    Lopez, J.C.; R Mcfarlane; Ulloa, J.

    2006-01-01

    Una técnica de reacción en cadena de la polimerasa transcriptasa reversa (RT-PCR) junto a una secuenciación fue usada para detectar y caracterizar genéticamente virus diferentes de bronquitis infecciosa aviar (VBIA) aislados en Chile. El procedimiento de RT-PCR incluyó el uso de los partidores NT1 y NT2, los cuales se localizaron cerca del término N del gen S1 y cubrieron la región hipervariable. La secuencia amplificada fue alineada y analizada con el programa computacional DNAman, y compara...

  14. Precautionary Effect of Recombinant Human Interleukin- 2 Injection on Chronic Bronchitis Caused by Smoke%重组人白介素-2注射液对烟熏所致慢性支气管炎的预防作用

    Institute of Scientific and Technical Information of China (English)

    汤玥; 程度胜; 路亮; 李谦; 胡伟

    2009-01-01

    为研究重组人白介素-2注射液对大鼠实验性慢性支气管炎的预防作用,使用烟熏法建立大鼠慢性支气管炎模型,选取3种阳性药物做对照.重组人白介素-2注射液预防给药对慢性支气管炎的发生、发展有一定的预防作用.

  15. Risco aumentado de sintomas respiratórios e bronquite crônica em mulheres que utilizam biocombustíveis na Nigéria Increased risk of respiratory symptoms and chronic bronchitis in women using biomass fuels in Nigeria

    OpenAIRE

    Olufemi Olumuyiwa Desalu; Adebowale Olayinka Adekoya; Bolawale Adedeji Ampitan

    2010-01-01

    OBJETIVO: Determinar a associação de sintomas respiratórios e bronquite crônica com o uso de biocombustíveis entre mulheres habitantes de áreas rurais do estado de Ekiti, sudoeste da Nigéria. MÉTODOS: De janeiro a junho de 2009, realizou-se um estudo transversal com uma amostra de 269 mulheres adultas. Um questionário adaptado do European Community Respiratory Health Survey foi aplicado para a obtenção de dados sobre características sociodemográficas, tipo de combustível utilizado para a prep...

  16. AcEST: DK948675 [AcEST

    Lifescience Database Archive (English)

    Full Text Available complex proteins psbY, ... 31 2.6 sp|P0C6V4|R1A_IBVBC Replicase polyprotein 1a OS=Avian infectious... 29 7....5 sp|P0C6V3|R1A_IBVB Replicase polyprotein 1a OS=Avian infectious ... 29 7.5 sp|P...plicase polyprotein 1a OS=Avian infectious bronchitis virus (strain Beaudette CK) GN=1a PE=3 SV=1 Length = 3...Replicase polyprotein 1a OS=Avian infectious bronchitis virus (strain Beaudette) ... Replicase polyprotein 1ab OS=Avian infectious bronchitis virus (strain Beaudette

  17. Levofloxacin

    Science.gov (United States)

    Levofloxacin is used to treat certain infections such as pneumonia, chronic bronchitis and sinus, urinary tract, kidney, prostate (a male reproductive gland), and skin infections. Levofloxacin is also used to prevent anthrax (a serious ...

  18. Levofloxacin Injection

    Science.gov (United States)

    Levofloxacin injection is used to treat infections such as pneumonia; chronic bronchitis; and sinus, urinary tract, kidney, prostate (a male reproductive gland), and skin infections. Levofloxacin injection is also used to prevent anthrax (a ...

  19. Amoxicillin

    Science.gov (United States)

    Amoxicillin is used to treat certain infections caused by bacteria, such as pneumonia; bronchitis; gonorrhea; and infections ... eliminate H. pylori, a bacteria that causes ulcers. Amoxicillin is in a class of medications called penicillin- ...

  20. What Is COPD?

    Medline Plus

    Full Text Available ... chronic bronchitis. Dorothy: Emphysema people have heard for years. But to hear COPD, I thought, now where ... number of people with COPD is increasing every year. More than 12 million people have been diagnosed ...

  1. 21 CFR 522.2640 - Tylosin.

    Science.gov (United States)

    2010-04-01

    ...) Indications for use. Treatment of bovine respiratory complex (shipping fever, pneumonia) usually associated...—(a) Dogs. Treatment of upper respiratory infections such as bronchitis, tracheobronchitis, tracheitis... Pasteurella multocida. (b) Cats. Treatment of upper respiratory infections when caused by Staphylococci...

  2. First Aid: Coughing

    Science.gov (United States)

    ... Center The Woes of Whooping Cough Your Lungs & Respiratory System Chilling Out With Colds Flu Center Bronchitis Why Should I Care About Germs? Lungs and Respiratory System Contact Us Print Resources Send to a friend ...

  3. Ozone: Good Up High, Bad Nearby

    Science.gov (United States)

    ... least 15. Reapply every two hours or after swimming or sweating. For UV Index forecasts, check local ... It can worsen bronchitis, Motor Vehicles emphysema, and asthma. “Bad” ozone also can reduce lung function and ...

  4. Too Many People Still Take Unneeded Antibiotics

    Science.gov (United States)

    ... of short-term respiratory conditions, such as colds, bronchitis, sore throats, and sinus and ear infections, the researchers reported. "About half of antibiotic prescriptions for acute respiratory conditions were unnecessary," Fleming-Dutra said. In ...

  5. How Does Smoking Affect your Health?

    Science.gov (United States)

    ... kidney, pancreas, ovary, cervix, stomach, colon, rectum, and acute myeloid leukemia. Lung diseases Smoking greatly increases your risk of getting long-term lung diseases like emphysema and chronic bronchitis. These diseases make it harder to breathe, and ...

  6. 77 FR 60617 - Child Health Day, 2012

    Science.gov (United States)

    2012-10-04

    ... and help decrease harmful toxins that can lead to acute bronchitis, asthma, cancer, and impaired... hundred and thirty-seventh. (Presidential Sig.) [FR Doc. 2012-24709 Filed 10-3-12; 8:45 am] Billing...

  7. Common Variable Immunodeficiency (CVID)

    Science.gov (United States)

    ... infections of the upper airway, sinuses, and lungs. Acute lung infections can cause pneumonia, and long-term lung infections may cause a chronic form of bronchitis known as bronchiectasis, which is characterized by thickened ...

  8. Taking Her Breath Away: The Rise of COPD in Women

    Science.gov (United States)

    ... Disparities Taking Her Breath Away: The Rise of COPD in Women Disparities in Lung Health Series More ... the U.S. live with chronic obstructive pulmonary disease (COPD), which includes chronic bronchitis and emphysema. Millions more ...

  9. COPD

    Science.gov (United States)

    COPD (chronic obstructive pulmonary disease) makes it hard for you to breathe. The two main types are chronic bronchitis and emphysema. The main cause of COPD is long-term exposure to substances that irritate ...

  10. Asthma and COPD: Differences and Similarities

    Science.gov (United States)

    ... and COPD: differences and similarities Share | Asthma and COPD: Differences and Similarities This article has been reviewed ... or you could have Chronic Obstructive Pulmonary Disease (COPD) , such as emphysema or chronic bronchitis. Because asthma ...

  11. What Is Cough?

    Science.gov (United States)

    ... With Clinical Trials Links Related Topics Asthma Bronchiectasis Bronchitis COPD Pneumonia Send a link to NHLBI to ... irritate these nerve endings. A cough can be acute, subacute, or chronic, depending on how long it ...

  12. How to breathe when you are short of breath

    Science.gov (United States)

    Pursed lip breathing; COPD - pursed lip breathing; Emphysema - pursed lip breathing; Chronic bronchitis - pursed lip breathing; Pulmonary fibrosis - pursed lip breathing; Interstitial lung disease - pursed lip breathing; Hypoxia - pursed lip breathing; ...

  13. Cystic Fibrosis

    Science.gov (United States)

    ... Trials Links Related Topics Bronchiectasis Bronchitis Cough Pneumonia Respiratory Failure Send a link to NHLBI to someone by ... to the lungs can cause severe breathing problems. Respiratory failure is the most common cause of death in ...

  14. Horny Goat Weed

    Science.gov (United States)

    ... for weak back and knees, joint pain, osteoarthritis, mental and physical fatigue, memory loss, high blood pressure, heart disease, bronchitis, liver disease, HIV/AIDS, polio, a blood disorder called chronic leucopenia, ...

  15. Cefixime

    Science.gov (United States)

    Cefixime is a cephalosporin antibiotic used to treat infections caused by bacteria such as pneumonia; bronchitis; gonorrhea; ... Cefixime comes as a tablet and liquid to take by mouth. It is usually taken once a ...

  16. Tobacco-Related Mortality

    Science.gov (United States)

    ... leukemia b Other heart diseases includes rheumatic heart disease, pulmonary heart disease, and other forms of heart disease. ... other arterial diseases. d COPD is chronic obstructive pulmonary disease and includes emphysema, bronchitis, and chronic airways obstruction. ...

  17. Measurement of airborne influenza virus during hen slaughtering in an ABSL-3E bioBUBBLE®

    Science.gov (United States)

    Several avian viral diseases, including avian influenza, Newcastle disease, infectious bronchitis or laryngotracheitis, are transmitted via respiratory droplets or by contact with contaminated fomites. Using high pathogenicity avian influenza (HPAI) virus as a model, the objective of the present st...

  18. Suppression of Pulmonary Host Defenses and Enhanced Susceptibility to Respiratory bacterial Infection in mice Following Inhalation Exposure to Trichloroethylene and Chloroform

    Science.gov (United States)

    Numerous epidemiologic studies have associated episodes of increased air pollution with increased incidence of respiratory disease, including pneumonia, croup, and bronchitis. Trichloroethylene (TCE) and chloroform are among 33 hazardous air pollutants identified by the U.S. Env...

  19. Diagnosing Asthma in Very Young Children

    Science.gov (United States)

    ... Listen Español Text Size Email Print Share Diagnosing Asthma in Babies & Toddlers Page Content Article Body One ... family with recurrent bronchitis or sinus problems. When Asthma is Not the Cause Your pediatrician will listen ...

  20. Fatigue

    Science.gov (United States)

    ... Other infections can tire you out, even without obvious symptoms. Parasites in your digestive system, bronchitis, other ... or injections can restore hormone levels to normal. Depression (see fact sheet 558). This is more than ...

  1. Pau D'arco

    Science.gov (United States)

    ... flu; sexually transmitted infections such as gonorrhea and syphilis; infections of the prostate and bladder; ringworm and ... Bronchitis. Arthritis-like pain. Sexually transmitted diseases (gonorrhea, syphilis). Boils. Other conditions. More evidence is needed to ...

  2. Healthy Living: Helping Your Child Breathe Easier

    Science.gov (United States)

    ... members can have a serious effect on the respiratory health of youngsters. One study shows that children up to two years old whose parents smoke suffer twice the rate of bronchitis and pneumonia as children of nonsmokers. ...

  3. COPD - what to ask your doctor

    Science.gov (United States)

    ... Below are some questions you may want to ask your health care provider to help you take ... What to ask your doctor about COPD; Emphysema - what to ask your doctor; Chronic bronchitis - what to ask your doctor; Chronic ...

  4. Moxifloxacin induced fatal hepatotoxicity in a 72-year-old man: a case report

    OpenAIRE

    Verma, Rajanshu; Dhamija, Radhika; Batts, Donald H.; Stephen C Ross; Loehrke, Mark E

    2009-01-01

    Moxifloxacin is a newer-generation synthetic fluoroquinolone that is used for treatment of acute bacterial sinusitis, acute exacerbation of chronic bronchitis, community acquired pneumonia, intra-abdominal infections and skin/skin structure infections. We describe a case of fatal hepatotoxicity caused by Moxifloxacin in a 72-year-old man. He presented with jaundice and epigastric tenderness that started one week after being treated for acute exacerbation of his chronic bronchitis with Moxiflo...

  5. Chronic obstructive pulmonary disease

    OpenAIRE

    NR Anthonisen

    2007-01-01

    The global prevalence of physiologically defined chronic obstructive pulmonary disease (COPD) in adults aged >40 yr is approximately 9-10 per cent. Recently, the Indian Study on Epidemiology of Asthma, Respiratory Symptoms and Chronic Bronchitis in Adults had shown that the overall prevalence of chronic bronchitis in adults >35 yr is 3.49 per cent. The development of COPD is multifactorial and the risk factors of COPD include genetic and environmental factors. Pathological changes in COPD are...

  6. Early History of Chronic Obstructive Pulmonary Disease 1808-1980.

    Science.gov (United States)

    Watson, R Ann; Pride, Neil B

    2016-04-01

    COPD has become a more popular research area in the last 3 decades, yet the first clear descriptions of acute and chronic bronchitis were in 1808. This brief history, comprehensively referenced, leads us through the early developments in respiratory physiology and their applications. It emphasises the early history of chronic bronchitis and emphysema in the 19(th) and early 20(th) centuries, long before the dominant effects of cigarette smoking emerged. This remains relevant to developing countries today. PMID:26418529

  7. Патоморфологія легень у курей при інфекційному бронхіті

    OpenAIRE

    Гуральська, С. В.; Guralska, S.

    2013-01-01

    The paper presents the morphological changes in the lungs of chickens sick with infectious bronchitis. In the lungs of chicken suffering from infectious bronchitis a considerable number of alveoli are filled with desquamated epithelium cells, lymphocytes. Alveolar partitions are swollen and infiltrated with epithelium. Some chicken also have narrowing of the clear space of the alveoli and their walls are thickened. Endothelium of blood vessels is swollen, intimae is increased and in the clear...

  8. Asthma and other pulmonary diseases in former elite athletes.

    OpenAIRE

    Kujala, U. M.; Sarna, S; Kaprio, J.; Koskenvuo, M.

    1996-01-01

    BACKGROUND: The prevalence of asthma is rising and there are recent reports of increasing asthma rates among top level skiers and runners in the Nordic countries. METHODS: The lifetime occurrence of pulmonary diseases (asthma, chronic bronchitis, emphysema) and current bronchitis symptoms was compared in former elite male athletes (n = 1282) who represented Finland between 1920 and 1965 at least once in international competitions and controls (n = 777) who, at the age of 20, were classified a...

  9. Foreign body aspiration – Sometimes a tough nut to crack

    OpenAIRE

    Sandhofer, Michael J.; Hans Salzer; Johannes Kulnig

    2015-01-01

    Foreign body aspiration (FBA) is a dangerous and potentially life-threatening event. We report the case of a 24-month old boy, who was initially presented with an episode of obstructive bronchitis to the family pediatrician. Then, while being treated with empiric antibiotics, he aspirated a peanut. Although resulting in a coughing episode, the mother did initially not ascribe any relevancy to it. Since the diagnosis of obstructive bronchitis had already been established, only an in-depth hist...

  10. Associação de bronquite plástica com enteropatia perdedora de proteínas após operação de Fontan Asociación de bronquitis plástica a la enteropatía perdedora de proteínas tras operación de fontan Association of plastic bronchitis to protein-losing enteropathy after fontan operation

    OpenAIRE

    Vanessa Alves Guimarães; Edmar Atik; Jussara Bianchi Castelli; Nana Miura Ikari; Ana Maria Thomaz; Antonio Augusto Barbosa Lopes

    2010-01-01

    Relatamos um caso incomum de associação de bronquite plástica (BP) com enteropatia perdedora de proteínas (EPP) em menina de 4 anos e 9 meses de idade. com dupla via de entrada de ventrículo único tipo esquerdo e concordância ventrículo-arterial submetida à cirurgia cavopulmonar total. com túnel lateral intracardíaco aos três anos. Tornaram-se chamativas a eliminação de molde brônquico de fibrina de 10 cm (BP) e a elevação de alfa-1-antitripsina de 52 mg/g de fezes. Em uso de sildenafila. pro...

  11. Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control study.

    Directory of Open Access Journals (Sweden)

    Jill Koshiol

    Full Text Available BACKGROUND: Chronic obstructive pulmonary disease (COPD has been consistently associated with increased risk of lung cancer. However, previous studies have had limited ability to determine whether the association is due to smoking. METHODOLOGY/PRINCIPAL FINDINGS: The Environment And Genetics in Lung cancer Etiology (EAGLE population-based case-control study recruited 2100 cases and 2120 controls, of whom 1934 cases and 2108 controls reported about diagnosis of chronic bronchitis, emphysema, COPD (chronic bronchitis and/or emphysema, or asthma more than 1 year before enrollment. We estimated odds ratios (OR and 95% confidence intervals (CI using logistic regression. After adjustment for smoking, other previous lung diseases, and study design variables, lung cancer risk was elevated among individuals with a history of chronic bronchitis (OR = 2.0, 95% CI = 1.5-2.5, emphysema (OR = 1.9, 95% CI = 1.4-2.8, or COPD (OR = 2.5, 95% CI = 2.0-3.1. Among current smokers, association between chronic bronchitis and lung cancer was strongest among lighter smokers. Asthma was associated with a decreased risk of lung cancer in males (OR = 0.48, 95% CI = 0.30-0.78. CONCLUSIONS/SIGNIFICANCE: These results suggest that the associations of personal history of chronic bronchitis, emphysema, and COPD with increased risk of lung cancer are not entirely due to smoking. Inflammatory processes may both contribute to COPD and be important for lung carcinogenesis.

  12. Comorbidity between chronic obstructive pulmonary disease and type 2 diabetes

    DEFF Research Database (Denmark)

    Meteran, Howraman; Backer, Vibeke; Kyvik, Kirsten Ohm; Skytthe, Axel; Thomsen, Simon Francis

    2015-01-01

    the relationship between type 2 diabetes and chronic bronchitis and COPD in adult twins, and to examine to what extent comorbidity between these diseases is explained by shared genetic or environmental factors. METHODS: Questionnaire data on chronic bronchitis and hospital discharge data on diagnosed...... COPD in 13,649 twins, aged 50-71 years, from the Danish Twin Registry were cross-linked with hospital discharge diagnosis data on type 2 diabetes from the Danish National Patient Registry. RESULTS: The risk of type 2 diabetes was higher in persons with symptoms of chronic bronchitis than in those...... on chronic bronchitis and type 2 diabetes, and between genetic effects on diagnosed COPD and type 2 diabetes, respectively, were 0.33 (0.00-0.79), p = 0.103, and 0.43 (0.00-0.98), p = 0.154. Non-shared environmental correlations between chronic bronchitis and type 2 diabetes were -0.13 (-0.43 to 0...

  13. Bronchial and pulmonary scintigraphy with radioactively marked aerosols

    International Nuclear Information System (INIS)

    In 97 patients with bronchitis, bronchial asthma, tuberculosis, sarcoidosis, pneumoconiosis, or tumors the mucociliary clearance and/or deposit pattern after inhalation of radioactively marked aerosols (1 mCi 99m Tc sulfur colloid) was studied. Normal values of the mucociliary 30 min. clearance for the central bronchial/lung periphery are 21%/15%. There was a decreased clearance with bronchitis (11/8%), bronchial asthma, emphysema, tuberculosis, sarcoidosis, trachiobronchial amyloidosis, pleural scarring or interstitial pneumona. Increased clearance (29/19%) was shown with pneumoconiosis. The correlation of deposit pattern and disease, for example, bronchitis, bronchial asthma, bullous emphysema, pleural scarring, partial lung resection, bronchopneumonia, or bronchial restriction, is described. In comparison of aerosol scintigraphy to perfusion scintigraphy and ventilation with gaseous xenon, the aerosol scintigraphy is superior to xenon for certain indications. The aerosol particles, which are larger in comparison to xenon, settle easier by obstructions or flow variations and thereby give better clinical indications of regional differences. (orig.)

  14. Dicty_cDB: Contig-U09099-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 1233( CP001185 |pid:none) Thermosipho africanus TCF52B, c... 42 0.080 DQ075323_1( DQ075323 |pid:none) Avian infectious...id:none) Methanobrevibacter smithii ATCC ... 40 0.30 AY606320_1( AY606320 |pid:none) Avian infectious bronch...itis virus ... 39 0.40 AY561715_1( AY561715 |pid:none) Avian infectious bronchitis virus ... 39 0.52 AL84450...L36900 |pid:none) Saccharomyces cerevisiae mitochondrion... 39 0.52 AF510565_1( AF510565 |pid:none) Avian infectious...39 0.52 AF352831_1( AF352831 |pid:none) Avian infectious bronchitis virus ... 39

  15. E rosettes in the uranium miners with lung cancer

    International Nuclear Information System (INIS)

    Rosette forming cells (RFC) were evaluated in the peripheral blood in healthy persons, and in lung cancer and chronic bronchitis patients. The levels of RFC in miners exposed to radiation and intact were compared. Two types of rosettes were listed 1) lymphocytes binding 1 or 2 sheep red blood cells (SRBC), 2) lymphocytes binding 3 or more SRBC. The sum of both types was calculated. Lung cancer patients were divided according to the TNM classification and histological types. The relative and absolute numbers of RFC in 1 μl of peripheral blood showed a reduced capacity of peripheral T-lymphocytes to form rosettes not only in patients with cancer or chronic bronchitis but also in controls exposed to radiation. It was also established that the control group exposed to radiation did not differ from cancer or chronic bronchitis patients. (author)

  16. Radiospirometry and perfusion scintigraphy in bronchiectases

    International Nuclear Information System (INIS)

    Radiospirometry and perfusion scintigraphy were carried out in 10 patients with unilateral bronchiectases comparing the obtained results with similar investigations in 10 healthy volunteers and 20 patients with chronic spastic bronchitis. In bronchiectasis cases abnormalities were demonstrated in both investigations with asymmetry of the observed changes.The most frequent findings were: reduced ventilation, reduced perfusion (even with its absence), decreased total capacity and vital capacity, and increased residual volume in the region containing bronchiectasis, as well as significant impairment of perfusion in the whole lung with bronchiectasis. This asymmetry with intensification of disturbances in the area of bronchiectasis, as well as evident restrictive changes in this part of the lungs differentiated cases of bronchiectasis from the cases of chronic bronchitis. The author thinks that radiospirometry and perfusion scintigraphy of the lungs are useful in the diagnosis and assessment of pulmonary function disturbances in patients with bronchiectasis and in differentiating these cases against chronic bronchitis. (author)

  17. Early diagnosis of morphologic-functional changes of the airways by a simple method of inhalation scintigraphy

    International Nuclear Information System (INIS)

    In order to validate a method of inhalation scintigraphy with 99mTc-labeled human serum albumin in the early diagnosis of morphologic-functional changes of the airways 35 volunteers and patients (12 healthy non-smokers and smokers each, 11 patients with bronchitis) were studied. Deposition of the aerosol immediately after inhalation was calculated quantitatively by a ROI technique and qualitatively (scoring of central deposition, homogeneity, and recognizability of lung outline). Additionally, the regional clearance of the inhaled aerosol was determined by continuous lung imaging up to 60 min (mainly regional mucociliary removal rates). Discrimination between healthy volunteers and patients with bronchitis was possible by means of deposition patterns immediately after inhalation. On the other hand, no differences could be recognized in this way between healthy non-smokers and smokers. Regional mucociliary removal was higher in non-smokers than in smokers, but there was no difference between smokers and patients with bronchitis. (orig.)

  18. Regional perfusion of the lungs in patients with chronic nonspecific pulmonary diseases based on scintigraphy data

    International Nuclear Information System (INIS)

    Perfusion scintigraphy of lungs with 99mTc-albumin microspheres was used for a study of changes of regional perfusion of lesser circulation in patients with chronic bronchitis of a varying degree of disturbed pulmonary hemodynamics. Even before a stable rise of pulmonary vascular resistance and developmemt of pulmonary arterial hypertension, chronic bronchitis was characterized by redistribution of blood flow from the lower parts of lungs to the upper ones, which progressed with disturbance of pulmonary arterial circulation and the development of chronic cor pulmonale. The use of scintigraphic indices of the upper and lower parts (U/L) prefusion ratio led to adequate assessment of a degree of redistribution of the pulmonary blood flow in patients with chronic bronchitis

  19. A study on the relationship between trace elements and respiratory system diseases

    International Nuclear Information System (INIS)

    19 elements (Ca, Mg, Fe, Se, Cu, Zn, etc.) in hair of 65 patients with chronic bronchitis, pulmonary emphysema and corpulmonale and 65 healthy persons were determined with instrumental neutron activation analysis. It was shown that the contents of Ca and Mg are lower while the contents of Fe, As and Co higher for the patients. For the patients with chronic bronchitis in attack period the contents of Ca and Mg are lower and the content of Fe higher than those in relaxed period. A highly positive relation between Ca and Mg contents was also found. In addition, inorganic elements in 'Kechuandeping' capsule, a prepared traditional Chinese medicine to treat chronic bronchitis, were determined, and the contents of Ca, Mg, Sr, etc. were found higher than the corresponding average values for 120 kinds of traditional Chinese medicines, indicating a possible shortage of Ca, Mg, etc. for the patients with respiratory-system diseased

  20. 王忆勤辨治肺系疾病验案撷菁%Professor Wang Yiqin's experience in differentiating and treating lung diseases

    Institute of Scientific and Technical Information of China (English)

    许文杰

    2013-01-01

    This paper introduces Professor Wang Yiqin' s experiences in the diagnosis and treatment of lung diseases by 4 cases; acute bronchitis, bronchial asthma, chronic bronchitis with pulmonary infection and tonsillitis.%通过总结急性支气管炎案、支气管哮喘案、慢性支气管炎合并肺部感染案、扁桃体炎案4则验案,分析王忆勤教授辨治肺系疾病的临床经验.

  1. AcEST: BP915474 [AcEST

    Lifescience Database Archive (English)

    Full Text Available R1A_IBVM Replicase polyprotein 1a OS=Avian infectious bronchitis virus (strain M4...bits) Value sp|P0C6V5|R1A_IBVM Replicase polyprotein 1a OS=Avian infectious ... 2...in OS=Mus musculus GN=Espl1 PE=2 SV=1 29 8.4 >sp|P0C6V5|R1A_IBVM Replicase polyprotein 1a OS=Avian infectious...VVPLATVPIVCSN 3594 >sp|P0C6Y3|R1AB_IBVM Replicase polyprotein 1ab OS=Avian infectious bronchitis virus (stra

  2. AcEST: BP921698 [AcEST

    Lifescience Database Archive (English)

    Full Text Available ptide repeat-containing protei... 30 5.6 sp|P0C6V4|R1A_IBVBC Replicase polyprotein 1a OS=Avian infectious...... 30 9.5 sp|P0C6V3|R1A_IBVB Replicase polyprotein 1a OS=Avian infectious ... 30 9....BC Replicase polyprotein 1a OS=Avian infectious bronchitis virus (strain Beaudett...3460 VLQSVTQEFSHIPSYAEYERAKNLYEKVLV 3489 >sp|P0C6V3|R1A_IBVB Replicase polyprotein 1a OS=Avian infectious...1AB_IBVBC Replicase polyprotein 1ab OS=Avian infectious bronchitis virus (strain

  3. AcEST: BP921648 [AcEST

    Lifescience Database Archive (English)

    Full Text Available us... 31 1.7 sp|P0C6V3|R1A_IBVB Replicase polyprotein 1a OS=Avian infectious ... 31..._IBVBC Replicase polyprotein 1a OS=Avian infectious bronchitis virus (strain Beau... ++C GG + +T+R+ Sbjct: 2878 YKFIKANCGDSFTIACAYGGTVVGLYPVTMRS 2909 >sp|P0C6V3|R1A_IBVB Replicase polyprotein 1a OS=Avian infectious...KANCGDSFTIACAYGGTVVGLYPVTMRS 2909 >sp|P0C6Y2|R1AB_IBVBC Replicase polyprotein 1ab OS=Avian infectious bronch...VB Replicase polyprotein 1ab OS=Avian infectious bronchitis virus (strain Beaudet

  4. Dicty_cDB: SSF511 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available erized transmembrane protein DDB... 223 4e-57 AY338732_1( AY338732 |pid:none) Avian infectious...d:none) Infectious bronchitis virus RNA (defec... 33 6.2 Z30541_1( Z30541 |pid:none) Avian infectious... bronchitis virus mRNA... 33 6.2 AY319651_1( AY319651 |pid:none) Avian infectious bronch...RecName: Full=Replicase polyprotein 1ab; Short... 33 6.2 AY641576_1( AY641576 |pid:none) Avian infectious

  5. Systemische Verfügbarkeit und Pharmakokinetik von Thymol nach oraler Applikation einer thymianhaltigen Zubereitung im Menschen

    OpenAIRE

    Kohlert, Claudia

    2002-01-01

    Ätherische Öle bzw. Ätherisch-Öl Komponenten sind etabliert in der Therapie der chronischen und akuten Bronchitis. Eine klinische Studie, die mit Thymianextrakt durchgeführt wurde, ließ auf die klinische Wirksamkeit bei akuter Bronchitis schließen. Zahlreiche pharmakodynamische Effekte konnten in vitro für Thymianextrakt bzw. das ätherische Thymianöl gezeigt werden, jedoch wurde bis jetzt die systemische Verfügbarkeit der betreffenden Verbindungen am Zielorgan noch nicht untersucht. Diesbezüg...

  6. Evaluation of the Waste Tire Resources Recovery Program and Environmental Health Policy in Taiwan

    Directory of Open Access Journals (Sweden)

    Chia-Ching Chen

    2009-03-01

    Full Text Available This paper examines the effectiveness of Taiwanese environmental health policies, whose aim is to improve environmental quality by reducing tire waste via the Tire Resource Recovery Program. The results confirm that implemented environmental health policies improve the overall health of the population (i.e. a decrease in death caused by bronchitis and other respiratory diseases. Current policy expenditures are far below the optimal level, as it is estimated that a ten percent increase in the subsidy would decrease the number of deaths caused by bronchitis and other respiratory diseases by 0.58% per county/city per year on average.

  7. Quantitative radiologic and functional evaluation of the lungs in children

    International Nuclear Information System (INIS)

    Ventilatory function of a selected groups of lung segments was determined both in children, suffering from recurrent bronchitis, and in healthy persons. A correlation of pulmonary transparency in extreme phases of respiration was taken for the unit of measurement. Spot magnifying radiography was performed without translucence. The result was defined in terms of proportional correlations of approximate calculated photometric parameters of an inspiration X-ray, as well as one of X-rays, obtained in the expiration phase. The method permits physicians to reveal pulmonary ventilation disorders in recurrent bronchitis

  8. 抗链球菌和葡萄球菌IgY抗体雾化吸入治疗慢性支气管炎急性发作期的疗效及其痰和血液中TNF-α、IL-2、IL-8水平的变化%Curative Effect of Treatment Patients with Chronic Bronchitis in Acute Stage of Attack and TNF-α,IL-2,IL-8 Change Levels in Sputum and Peripheral Blood by Aerosol Inhalation Anti-streptococcus and Staphylococcus Chicken Egg Yolk Immunoglobulin Antibody

    Institute of Scientific and Technical Information of China (English)

    王玉梅; 唐宁; 张敏

    2010-01-01

    目的 探讨抗链球菌和葡萄球菌IgY抗体雾化吸入治疗慢性支气管炎急性发作期的临床疗效及其痰和血液中肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、白细胞介素2 (interleukin-2,IL-2)、白细胞介素8(interleukin-8,IL-8)水平的变化.方法 将100例慢性支气管炎急性发作期患者按随机数字表法分为2组:试验组和对照组,每组50例.试验组采用抗链球菌和葡萄球菌IgY抗体雾化吸入治疗;对照组采用左氧氟沙星治疗.采用ELISA法检测2组患者痰上清液和血清中TNF-α、IL-2、IL-8的水平.观察2组患者治疗前、治疗7 d 后血清及痰上清液IL-2、IL-8、TNF-α的变化及治疗7 d 后临床疗效等情况.结果 试验组、对照组总有效率分别为78.0%、82.0%,2组比较差异无统计学意义(P>0.05).试验组、对照组患者治疗7 d 后血清IL-8和TNF-α水平均较治疗前显著降低[(285.71±109.14)ng·L-1、(13.44±5.73)pg·L-1 vs(443.24±128.77)ng·L-1、(29.57±7.24)pg·L-1,(337.57±153.28)ng·L-1、(15.41±6.25)pg·L-1 vs (438.92±133.68) ng·L-1、( 28.86±7.78) pg·L-1,均P<0.05].试验组治疗7 d 后痰上清液IL-8、TNF-α水平均较对照组下降更显著[(385.93±133.17)ng·L-1、(16.23±7.41)pg·L-1 vs(439.71±142.36)ng·L-1、(21.44 ±11.36)pg·L-1,均P<0.05].结论 抗链球菌和葡萄球菌IgY抗体雾化吸入治疗慢性支气管炎急性发作期疗效显著,并能减轻局部炎症反应.

  9. Ambient nitrogen oxides exposure and early childhood respiratory illnesses

    Czech Academy of Sciences Publication Activity Database

    Ghosh, R.; Joad, J.; Beneš, I.; Dostál, Miroslav; Šrám, Radim; Hertz-Picciotto, I.

    2012-01-01

    Roč. 39, č. 1 (2012), s. 96-102. ISSN 0160-4120 R&D Projects: GA MŽP(CZ) SP/1B3/50/07 Institutional research plan: CEZ:AV0Z50390703 Keywords : air pollution * bronchitis * croup Subject RIV: DN - Health Impact of the Environment Quality Impact factor: 6.248, year: 2012

  10. Euphorbia hirta: Its chemistry, traditional and medicinal uses, and pharmacological activities

    OpenAIRE

    Sunil Kumar; Rashmi Malhotra; Dinesh Kumar

    2010-01-01

    The oldest remedies known to mankind are herbal medicines. India is known worldwide for its Ayurvedic treatment. Euphorbia hirta is often used traditionally for female disorders, respiratory ailments (cough, coryza, bronchitis, and asthma), worm infestations in children, dysentery, jaundice, pimples, gonorrhea, digestive problems, and tumors. It is reported to contain alkanes, triterpenes, phytosterols, tannins, polyphenols, and flavanoids. This review describes the medicinal properties, chem...

  11. Hjerteinfarkter og fatal hjerteinsufficiens hos en fem måneder gammel dreng med abnorm afgang af venstre koronararterie

    DEFF Research Database (Denmark)

    Fenger-Grøn, Jesper; Aunsholt, Lise; Hansborg, Niels

    2008-01-01

    A five month old boy was admitted with symptoms of asthmatic bronchitis. Careful anamnesis revealed failure to thrive latest month, cough since age of three weeks and a few episodes of severe crying. He had cardiomegaly and an electrocardiogram showed Q waves and ST segment elevation in several...

  12. Mucus hypersecretion in the airway

    Institute of Scientific and Technical Information of China (English)

    WANG Ke; WEN Fu-qiang; XU Dan

    2008-01-01

    @@ Mucus hypersecretion is a distinguishing feature of Chronic intlammation diseases,such as asthma,1chronic bronchitis.2 bronchiectasis3 and cystic fibrosis.4Mucus hypersecretion leads to impairment of mucociliary clearance,abnormal bacterial plantation,mucus plug in the airway,and dysfunction of gas exchange.5

  13. Training for thorax diagnostics. Systematic cardiopulmonary image analysis; Trainer Thoraxdiagnostik. Systematische kardiopulmonale Bildanalyse

    Energy Technology Data Exchange (ETDEWEB)

    Kirchner, Johannes [Allgemeines Krankenhaus Hagen gem.GmbH (Germany). Klinik fuer Diagnostische und Interventionelle Radiologie

    2010-07-01

    The training book on thorax diagnostics using image analysis is supposed to be a supplement to the usual textbooks based on comprehensive experiences of radiologists. The covered issues are the following: heart insufficiency, acute/ chronic bronchitis and pulmonary emphysema; pneumonia and tuberculosis; bronchial carcinoma; lung fibrosis, sarcoidosis and pneumoconiosis, pleural effusion and pneumothorax.

  14. Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects

    OpenAIRE

    Fatemeh Forouzanfar; Bibi Sedigheh Fazly Bazzaz; Hossein Hosseinzadeh

    2014-01-01

    Nigella sativa seeds have wide therapeutic effects and have been reported to have significant effects against many ailments such as skin diseases, jaundice, gastrointestinal problems, anorexia, conjunctivitis, dyspepsia, rheumatism, diabetes, hypertension, intrinsic hemorrhage, paralysis, amenorrhea, anorexia, asthma, cough, bronchitis, headache, fever, influenza and eczema. Thymoquinone (TQ) is one of the most active constituent and has different beneficial properties. Focus on antimicrobial...

  15. Frequent respiratory tract infections in children. The role of environmental and genetic factors.

    NARCIS (Netherlands)

    Ruskamp, J.M.

    2009-01-01

    Respiratory tract infections (RTI), presenting as common cold, pharyngitis, tonsillitis, acute otitis media, bronchitis or pneumonia are a major health problem in children. In this thesis common environmental and host factors, as well as plausible genetic factors were evaluated in a large birth coho

  16. [Herbal medicines against respiratory diseases--traditional empiricism or pharmacological evidence?].

    Science.gov (United States)

    2014-11-01

    Sinusitis and bronchitis belong to the most frequent respiratory infections. The relevant guidelines mention the therapy with herbal substances and assign a good activity to cineole and Myrtol as well as to combination preparations with cowslip. There is no final statement of the guidelines' authors concerning the extract of Pelargonium sidoides. Further studies will be necessary to give reliable therapeutic recommendations. PMID:25632601

  17. 75 FR 73109 - Guidance for Industry on Antibacterial Drug Products: Use of Noninferiority Trials to Support...

    Science.gov (United States)

    2010-11-29

    ... accordingly. In the Federal Register of October 15, 2007 (72 FR 58312), FDA announced a notice of availability... following indications: Acute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis, and acute bacterial otitis media. Since FDA issued the draft guidance, there have been public discussions...

  18. Cardiovascular Complications in Chronic Obstructive Pulmonary Disease with Reference to 2D Echocardiography Findings

    Directory of Open Access Journals (Sweden)

    Vikram B Vikhe

    2013-08-01

    Results: Emphysema and chronic bronchitis was present in 38% and 62% respectively. Echocardiographic evidence of cor-pulmonale and pulmonary hypertension was found in 70% of the patients. Conclusions: Echocardiography is more sensitive than electrocardiography in detecting PAH and right ventricular dysfunction in COPD. [Natl J Med Res 2013; 3(4.000: 385-388

  19. Antibiotic Safety

    Science.gov (United States)

    ... nose, sore throat, sneezing, cough, headache • Influenza (flu)—fever, chills, body aches, headache, sore throat, dry cough • Most coughs • Acute bronchitis (cough, fever)—almost always caused by viruses • Pharyngitis (sore throat)— ...

  20. Training for thorax diagnostics. Systematic cardiopulmonary image analysis

    International Nuclear Information System (INIS)

    The training book on thorax diagnostics using image analysis is supposed to be a supplement to the usual textbooks based on comprehensive experiences of radiologists. The covered issues are the following: heart insufficiency, acute/ chronic bronchitis and pulmonary emphysema; pneumonia and tuberculosis; bronchial carcinoma; lung fibrosis, sarcoidosis and pneumoconiosis, pleural effusion and pneumothorax.