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Sample records for bronchitis chronic

  1. Chronic Bronchitis

    Science.gov (United States)

    ... breathing. You may also have other tests. Chronic bronchitis is a long-term condition that keeps coming back or never goes away completely. If you smoke, it is important to quit. Treatment can help with your symptoms. It often includes ...

  2. Living with Chronic Bronchitis

    Science.gov (United States)

    ... Health Topics » Bronchitis » Living With Chronic Bronchitis Explore Bronchitis What Is... Other Names Causes Who Is at Risk Signs & Symptoms Diagnosis Treatments Prevention Living With Clinical Trials Links Related Topics ...

  3. Zabofloxacin for chronic bronchitis.

    Science.gov (United States)

    Kocsis, B; Szabo, D

    2016-09-01

    Treatment of lower respiratory tract infection poses as an ongoing challenge among respiratory tract diseases. Bacterial infections are causes of acute exacerbations in chronic bronchitis and indications for antibacterial therapy. Several antibiotics were applied to treat bacterial infections in chronic bronchitis, among them fluoroquinolones are considered potent, broad-spectrum agents with excellent tissue penetration. This monograph focuses on zabofloxacin, a novel fluoroquinolone agent recently approved and launched in South Korea, and summarizes the drug's antibacterial efficacy, pharmacokinetic properties and toxicity. Recent advances concerning fluoroquinolones in chronic bronchitis will be discussed, along with a comparison between zabofloxacin and moxifloxacin. Zabofloxacin has proved to be noninferior to moxifloxacin against major community-acquired Gram-positive and Gram-negative respiratory tract pathogens and found to be well tolerated in both oral and parenteral administrations. These features can make it a potential antimicrobial agent in therapy of chronic bronchitis and other lower respiratory tract infections.

  4. Chronic bronchitis in an elderly population

    DEFF Research Database (Denmark)

    Lange, Peter; Parner, Jan; Prescott, Eva

    2003-01-01

    in order to describe the prevalence and prognostic implications of chronic bronchitis in individuals 65 years or older we analysed data from The Copenhagen City Heart Study.......in order to describe the prevalence and prognostic implications of chronic bronchitis in individuals 65 years or older we analysed data from The Copenhagen City Heart Study....

  5. Bronchitis

    Science.gov (United States)

    ... when symptoms get much worse than usual. Chronic bronchitis is a serious, long-term medical condition. Early diagnosis and treatment, combined with quitting smoking and avoiding secondhand smoke, ...

  6. 77 FR 59929 - Guidance for Industry on Acute Bacterial Exacerbations of Chronic Bronchitis in Patients With...

    Science.gov (United States)

    2012-10-01

    ... treatment of acute bacterial exacerbations of chronic bronchitis in patients with chronic obstructive... Bacterial Exacerbations of Chronic Bronchitis-- Developing Antimicrobial Drugs for Treatment'' published in... Chronic Bronchitis in Patients With Chronic Obstructive Pulmonary Disease: Developing Antimicrobial...

  7. A controlled trial of ambroxol in chronic bronchitis.

    Science.gov (United States)

    Guyatt, G H; Townsend, M; Kazim, F; Newhouse, M T

    1987-10-01

    Ambroxol is a mucolytic agent which is widely used in chronic bronchitis in Europe. We conducted a double-blind randomized controlled trial of ambroxol vs matched placebo in 90 patients with chronic bronchitis and difficulty clearing secretions. It was concluded that there was no advantage to taking ambroxol.

  8. [New pharmaceuticals in treatment of chronic dust bronchitis].

    Science.gov (United States)

    Kosarev, V V; Vakurova, N V; Babanov, S A

    2007-01-01

    The study was dedicated to the assessment of the therapeutic possibilities provided by erespal (fenspirid) as a new class of pharmaceuticals inhibiting the inflammatory process, in patients with chronic dust bronchitis.

  9. Chronic Bronchitis - Multiple Languages: MedlinePlus

    Science.gov (United States)

    ... Somali) Bilingual PDF Health Information Translations Spanish (español) Bronquitis crónica Ukrainian (Українська) Bronchitis Бронхіт - Українська (Ukrainian) Bilingual ...

  10. Features of Chronic Bronchitis in Different Age Groups

    Directory of Open Access Journals (Sweden)

    Galina L. Ignatova

    2014-03-01

    Full Text Available Background: Lung diseases are assuming greater relevance and importance today. Chronic bronchitis is a self-nosology, which may precede the development of COPD, the importance of which can hardly be overestimated. The main problem in this disease is caused by late diagnosis and treatment due to the delay by patients in seeking medical help. The aim of the work was to study the distribution and exposure to tobacco smoke, especially chronic bronchitis, depending on various factors, including age. Methods: We examined 1779 persons, including 855 men and 924 women. The mean age of the population was 35.83±8.3 years. We conducted surveys and spirometry. The outcome was assessed after a bronchodilation test was performed with salbutamol 400 mcg. We performed all statistical analysis using software package Statistica 10. Results: We identified chronic bronchitis in 9.2% of the cases in the group of younger individuals and in 14.9% of the cases in the group of older individuals, during the active detection of chronic bronchitis using questionnaires. The prevalence of cigarette smoking was slightly higher among the younger (39.5% than the older persons (33.6%; the frequency of smoking in a group of chronic bronchitis was reliably higher. Also, in this group, the performance spirometry reliably decreased. Conclusions: Outpatient survey is an effective method of identifying chronic bronchitis. Smoking is a major risk factor in the group of young respondents and the prevalence of smoking is inversely related to the education level of the respondents, regardless of age. As the decline in the Forced Expiratory Volume (FEV1 and FEV1/FVC is the main criterion diagnosis of COPD, it revealed significant declines in the FEV1 of the younger smoking individuals, which may help to predict the development of COPD in the older age group.

  11. A ferret model of COPD-related chronic bronchitis

    OpenAIRE

    Raju, S. Vamsee; Kim, Hyunki; Byzek, Stephen A.; Tang, Li Ping; Trombley, John E; Jackson, Patricia; Rasmussen, Lawrence; Wells, J. Michael; LIBBY, EMILY FALK; Dohm, Erik; Winter, Lindy; Samuel, Sharon L.; Kurt R. Zinn; Blalock, J. Edwin; Schoeb, Trenton R.

    2016-01-01

    Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the US. The majority of COPD patients have symptoms of chronic bronchitis, which lacks specific therapies. A major impediment to therapeutic development has been the absence of animal models that recapitulate key clinical and pathologic features of human disease. Ferrets are well suited for the investigation of the significance of respiratory diseases, given prior data indicating similarities to human airway p...

  12. A ferret model of COPD-related chronic bronchitis

    Science.gov (United States)

    Raju, S. Vamsee; Kim, Hyunki; Byzek, Stephen A.; Tang, Li Ping; Trombley, John E.; Jackson, Patricia; Rasmussen, Lawrence; Wells, J. Michael; Libby, Emily Falk; Winter, Lindy; Samuel, Sharon L.; Zinn, Kurt R.; Blalock, J. Edwin; Schoeb, Trenton R.; Dransfield, Mark T.; Rowe, Steven M.

    2016-01-01

    Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the US. The majority of COPD patients have symptoms of chronic bronchitis, which lacks specific therapies. A major impediment to therapeutic development has been the absence of animal models that recapitulate key clinical and pathologic features of human disease. Ferrets are well suited for the investigation of the significance of respiratory diseases, given prior data indicating similarities to human airway physiology and submucosal gland distribution. Here, we exposed ferrets to chronic cigarette smoke and found them to approximate complex clinical features of human COPD. Unlike mice, which develop solely emphysema, smoke-exposed ferrets exhibited markedly higher numbers of early-morning spontaneous coughs and sporadic infectious exacerbations as well as a higher level of airway obstruction accompanied by goblet cell metaplasia/hyperplasia and increased mucus expression in small airways, indicative of chronic bronchitis and bronchiolitis. Overall, we demonstrate the first COPD animal model exhibiting clinical and pathologic features of chronic bronchitis to our knowledge, providing a key advance that will greatly facilitate the preclinical development of novel treatments for this disease. PMID:27699245

  13. [Chronic obstructive bronchitis: definitions, risk factors and prevention (author's transl)].

    Science.gov (United States)

    Brille, D; Kauffmann, F; Oriol, P; Querleux, E

    1976-01-01

    Chronic obstructive bronchitis is defined as persistent diffuse airways obstruction frequently associated with chronic expectoration. This disease is particularly disabling and its medico-social burden implies that measures be taken. Risk factors of chronic obstructive bronchitis can be classified according to their presently known importance: tobacco, professional exposure, air pollution, viral and bacterial respiratory infections, poor socio-economic and cultural conditions, upper and lower airways infections during childhood, other environmental factors, genetic factors. Prevention needs that research be developed, in particular for factors, as hereditary ones, relations between childhood and adult respiratory diseases and characteristics of the "susceptible smokers". Knowledge of risk factors previously quoted allows to propose public-health actions. Firstly, true preventive action of general nature: fight against tobacco consumption, reduce atmospheric pollution, improve work and life conditions. Secondly, in order to prevent the disabling state of chronic bronchitis, it would be necessary to take care of patients at the initial state. A control trial is proposed to determine the level of symptoms and of reduction of ventilatory values at which an action is needed and the best "preventive therapeutical" protocol to be applied to these patients.

  14. Chronic bronchitis sub-phenotype within COPD : inflammation in sputum and biopsies

    NARCIS (Netherlands)

    Snoeck-Stroband, J B; Lapperre, T S; Gosman, M M E; Boezen, H M; Timens, W; ten Hacken, N H T; Sont, J K; Sterk, P J; Hiemstra, P S

    2008-01-01

    The presence of chronic bronchitis predicts a more rapid decline of forced expiratory volume in one second (FEV(1)) in patients with chronic obstructive pulmonary disease (COPD). The hallmark of COPD is airway inflammation. It was hypothesised that COPD patients with chronic bronchitis are character

  15. TREATMENT OF CHRONIC BRONCHITIS WITH FIFTY-YING-ACUPUNCTURE THERAPY

    Institute of Scientific and Technical Information of China (English)

    袁民

    2001-01-01

    Objective: To observe the clinical effect of Fifty-ying acupuncture therapy for treatment of chronic bronchitis, and to explore its underlying mechanisms. Methods: A total of 36 out- and in-patients with chronic bronchitis including 10 cases of asthma were subjected into this study. Among them, 20 cases were qi-deficiency type and 16 qi-yin-deficiency with phlegm-clamp type. The changes of symptoms, T-lymphocyte subgroups of CD3+, CD4+, CD8+,CD4+/CD8+, soluble interleuki-2 receptor ( SIL-2R), interleukin-6(IL-6), IgG, IgA and IgM before and after treatment were observed and detected using monoclonal indirect fluorescence method, enzyme linked immunosorbent assay (ELISA) and nephelometry respectively. Results: (1)The effective rate of qi-dificiency type was 100% and that of qi-yin-deficiency with phlegm-damp type 87.5%. (2) After acupuncture treatment, in qi-deficiency type patients, serum IgG, IgA and IgM contents increased significantly (P< 0. 001) in comparison with pre-treatment and in qi-yin-deficiency with phlegm-damp type patients, IgG level lowered obviously. Serum SIL-2R and CD4+/CD8+ decreased obviously(P<0.01, 0.001), CD3+, CD4+ and CD8+ increased evidently (P<0.01). Conclusion: The Fifty-ying acupuncture therapy can better clinical symptoms of chronic bronchitis patients through its resultant up-regulation of the immune system function.

  16. Chronic bronchitis in West Sweden – a matter of smoking and social class

    Directory of Open Access Journals (Sweden)

    Malin Axelsson

    2016-07-01

    Full Text Available Background: Although chronic bronchitis is associated with impaired quality of life, hospitalisations and increased mortality, it has been less in focus after the introduction of the term chronic obstructive pulmonary disease (COPD. There are no recent published data on the prevalence of chronic bronchitis from the Scandinavian countries. Aim: The main aim of the present study was to estimate the prevalence of chronic bronchitis in West Sweden by using data from a large-scale epidemiological study of the general population. A further aim was to identify current risk factors for chronic bronchitis in a population with a major decrease in the proportion of smokers. Methods: From the 18,087 questionnaire responders out of 30,000 invited to participate at the West Sweden Asthma Study, 2,000 subjects were randomly selected and invited to detailed clinical examinations performed during 2009–2013. A total of 1,172 subjects aged 17–79 participated in the examinations which included, among others, spirometry and structured interviews. Chronic bronchitis was defined according to reported symptoms. Results: The overall prevalence of chronic bronchitis was 7.2% (men 7.6%; women 6.8% ns, and it was 8.7% in subjects older than age 60. Chronic bronchitis was strongly associated with smoking, defined both as current smoking status and pack-years. Other risk factors were increasing age, low socio-economic class and urban living. Of those with chronic bronchitis, 22% fulfilled the GOLD criteria of COPD. Conclusion: The prevalence of chronic bronchitis was somewhat lower than found by studies in Sweden in the 1980s and the prevalence was now similar in men and women. Although smoking was still the dominating risk factor for chronic bronchitis, the relative importance of smoking had decreased parallel with a decreasing smoking prevalence, while the relative importance of other factors than smoking had increased compared to previous studies.

  17. Occupation, chronic bronchitis, and lung function in young adults - An international study

    NARCIS (Netherlands)

    Zock, JP; Sunyer, J; Kogevinas, M; Kromhout, H; Burney, P; Anto, JM

    2001-01-01

    We studied the relationship between occupational exposures, chronic bronchitis, and lung function in a general population survey in 14 industrialized countries, including 13,253 men and women aged 20 to 44 yr. We studied associations between occupational group, occupational exposures, bronchitis sym

  18. [X-ray semiotics of the morphological and functional changes in chronic bronchitis].

    Science.gov (United States)

    Khomenko, A G; Dmitrieva, L I; Polak, J; Gapon'ko, G A; Starilova, I P

    1985-01-01

    The authors analysed structural disorders of a pulmonary pattern in patients with non-obstructive, obstructive and purulent bronchitis. Characteristic x-ray symptom-complexes were singled out for each clinical variant of the disease. In addition to roentgenomorphological changes functional disorders showing changes of biomechanics in patients with chronic bronchitis were revealed at roentgenopneumopolygraphy.

  19. The determinants of chronic bronchitis in Aboriginal children and youth

    Science.gov (United States)

    Hossain, Alomgir; Konrad, Stephanie; Dosman, James A; Senthilselvan, Ambikaipakan; McCrosky, Jesse; Pahwa, Punam

    2012-01-01

    BACKGROUND: There is limited knowledge concerning chronic bronchitis (CB) in Canadian Aboriginal peoples. OBJECTIVE: To determine the prevalence (crude and adjusted) of CB and its associated risk factors in Canadian Aboriginal children and youth six to 14 years of age. METHODS: Data from the cross-sectional Aboriginal Peoples Survey were analyzed in the present study. Logistic regression analysis was used to determine risk factors influencing the prevalence of CB among Aboriginal children and youth. The balanced repeated replication method was used to compute standard errors of regression coefficients to account for clustering inherent in the study design. The outcome of interest was based on the question: “Have you been told by a doctor, nurse or other health professional that you have chronic bronchitis?” Demographics, environment and population characteristics (predisposing and enabling resources) were tested for an association with CB. RESULTS: The prevalence of CB was 3.1% for boys and 2.8% for girls. Other significant risk factors of CB were age (OR 1.38 [95% CI 1.24 to 1.52] for 12 to 14 year olds versus six to eight year olds), income (OR 2.28 [95% CI 2.02 to 2.59] for income category <$25,000/year versus ≥$85,000/year), allergies (OR 1.96 [95% CI 1.78 to 2.16] for having allergies versus no allergies), asthma (OR 7.61 [ 95% CI 6.91 to 8.37] for having asthma versus no asthma) and location of residence (rural/urban and geographical location). A significant two-way interaction between sex and body mass index indicated that the relationship between the prevalence of CB and body mass index was modified by sex. DISCUSSION: The prevalence of CB was related to well-known risk factors among adults, including older age and lower annual income. PMID:23248806

  20. STUDY ON INFLAMMATORY CELLS IN BALF OF SMOKE-INDUCED CHRONIC BRONCHITIS RAT MODEL

    Institute of Scientific and Technical Information of China (English)

    李庆云; 黄绍光; 吴华成; 程齐俭; 项轶; 万欢英

    2004-01-01

    Objective To establish a smoke-induced chronic bronchitis rat model and evaluate the pathological change semi-quantitatively, and study the characteristics of the inflammatory cells in the bronchoalveolar lavage fluid (BALF) in various stages. Methods Chronic bronchitis sequential rat model was established by passively inhaling smoke mixture. Experiments were performed in 30 young male Sprague-Dawley rats, which comprised 5 groups in random, i.e.,4 chronic bronchitis model groups and I control group. After stained with hematoxylin and eosin, the specimens were studied by semi-quantitative method to evaluate the morphologic changes in various stages. Meanwhile, the inflammatory cells of the BALF and the activity of myeloperoxidase ( MPO ) of lung tissue were analysed. Results During the process of the chronic bronchitis, the pathologic score was increasing as time went on, and the typical morphologic changes of chronic bronchitis emerged in the group 7 weeks. The total number of inflammatory cells in BALF was increasing as time went on, correlated with the pathologic scores ( P < 0. 01 ).And the percentage of lymphocyte increased as well as positively correlated with pathologic scores ( P < 0. 05 ),whereas that of macrophage decreased and negatively correlated with pathologic scores (P <0. 05). The MPO lever of lung tissue was correlated with the pathologic scores ( P < 0. 01 ). But the percentage of the neutrophil in the BALF was just in a high level during the first week, then it maintained relatively lower. Conclusion Smoke-induced chronic bronchitis is a slowly progressive inflammation process. The model we established is convenient and simple for the longitudinal study on the inflammatory process of chronic bronchitis and the therapy in the early stage. The semi-quantitative evaluation for the pathological change is with much more value. During the inflammatory sequential process of early stage of chronic bronchitis, the cellular characteristics are

  1. Clinical Peculiarities of Recurrent and Chronic Bronchitis in Children (Part 1)

    OpenAIRE

    Makian, M. V.; Harhaun, V. A.; Maidannyk, V. H.

    2015-01-01

    Subjective manifestations in children with recurrent and chronic bronchitis were the subject of the research.The objective of the research was to evaluate the main clinical manifestations of recurrent and chronic bronchitis, analyze risk factors and preconditions for their occurence in children.Materials and methods of research. The comprehensive clinical and anamnestic examination of 120 children with bronchopulmonary pathology at the age of 3 to 18 (average age was 10.5±1.1 years) was condu...

  2. [Comparative investigations to the epidemiology of chronic bronchitis in Erfurt and Riga (author's transl)].

    Science.gov (United States)

    Berzon, R; Utkin, W W; Marga, J; Stepanow, I N; Anderson, M A

    1980-01-01

    Studies concerning the prevalence of chronic bronchitis were conducted in Erfurt in 1971 and in Riga in 1974, comprising a standard interview and measurements of vital capacity and forced expiratory volume. Results in both towns are compared and critically discussed. Chronic bronchitis and obstruction are more frequent in Riga, while obstruction shows a better correlation to the severity of clinical signs in Erfurt. The influence of age, smoking, and hemoptysis are also compared; the latter showing no difference between both towns.

  3. [Education of patients with asthma, chronic bronchitis and pulmonary emphysema].

    Science.gov (United States)

    Krstić-Burić, M; Pavicić, F; Rozman, A; Bogić, B; Crc, M; Plesko, N; Sarajlić, N

    1997-02-01

    Patients' education belongs to the most efficient therapeutic measures in the management of asthma, chronic bronchitis and pulmonary emphysema. The following paper reports the experience in the educational programme at the Polyclinic for Respiratory Diseases in Zagreb. Each patient's education lasted 5 days, 3 lessons per day, in groups of 10-15 persons. The education was carried out by a teaching team consisting of pulmonologists, psychosomatologist, pharmacist, physiotherapist and biometeterologist. From March 1995 to February 1996 135 persons completed the educational programme, 65 of whom were asthma patients. Data on cough and dyspnoea, skills in inhaler and breathing technique were collected at the beginning and 3 months after the education in all asthma patients. Three months after the education the asthma patients showed a significant decrease in dyspnoea and a significant improvement in inhaler and breathing technique. A standard questionnaire was given to all patients at the end of the education and in more than 80% the education was well accepted by the patients. Initial results are encouraging and the programme should be expanded to all parts of Croatia.

  4. [Features of chronic occupational bronchitis in nonferrous metallurgy workers].

    Science.gov (United States)

    Roslaia, N A; Likhacheva, E I; Vagina, E R; Roslyĭ, O F; Zhovtiak, E P; Iarina, A L; Varzina, N V

    2004-01-01

    The authors summarized results of periodic medical examinations and deep clinical studies of metallurgy workers with bronchial and pulmonary disorders. The article covers clinical and functional characteristics of toxic and dust bronchitis, clinical course and manifestations.

  5. Efficacy Observation on Modified Chronic Bronchitis Decoction for Chronic Bronchitis%慢支汤加减治疗慢性支气管炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    范育玲

    2016-01-01

    Objective:To observe the efficacy of self-made modified chronic bronchitis decoction for chronic bronchitis. Methods: 60 cases of pa-tients with chronic bronchitis were randomly divided into observation group (30 cases) and control group (30 cases), both of which were treated by conventional medication of artibiotics and cough expectorant medicine (ambroxol hydrochloride or pentoxyverine), while observation group com-bined with orally taking modified chronic bronchitis decoction (aster, radix stemonae, radix platycodi, etc) on the basis of conventional medication, observed the efficacy and the improvement of cough symptom after 7 days of treatment. Results:The overall response rate of observation group was 93.33%, which was higher than 76.67% that of control group (P<0.05); after treatment, the improvement of cough symptom score of observation group was better than that of control group (P<0.05). Conclusion:Modified chronic bronchitis decoction can improve the efficacy of the treatment of chronic bronchitis and relieve cough symptom, deserves clinical promotion and application.%目的:观察自拟慢支汤加减治疗慢性支气管炎的疗效。方法:将60例慢性支气管炎患者随机分为观察组和对照组各30例,均给予抗生素、祛痰止咳(盐酸氨溴索或喷托维林)等常规药物治疗,观察组则在常规药物治疗基础上服用加减自拟慢支汤(紫苑、百部、桔梗等),治疗7天观察两组临床疗效及咳嗽症状改善情况。结果:观察组总有效率为93.33%,显著高于对照组的76.67%(P<0.05);治疗后,观察组咳嗽症状积分改善程度显著优于对照组(P<0.05)。结论:自拟慢支汤加减治疗慢性支气管炎能提高临床疗效,有效缓解咳嗽症状,值得临床推广应用。

  6. Clinical Observation in 31 Cases of Chronic Bronchitis at Remission Stage Treated with Bufei Keli

    Institute of Scientific and Technical Information of China (English)

    刘杨春; 王乃红; 王娜; 刘冠萍; 阎惠芳

    2003-01-01

    To observe the therapeutic effects of a Chinese drug Bufei Keli (补肺颗粒 granules for invigorating thelung) in the treatment of chronic bronchitis at remission stage, 62 cases were randomly divided into aThe results turned out to be that the short-term clinically controlled and markedly effective rate was77.42% and the long-term relapse-resisting markedly effective rate was 74.2% in the treatment group,which were obviously higher than 45.16% and 38.71% respectively in the control group (P<0.05). And theincrease in contents of SOD and CD3 and the decrease in LPO content in the treatment group were alsobigger than that in the control group (P<0.01). It is therefore concluded that Bufei Keli can improve qideficiency syndrome and raise the immunity of patients with chronic bronchitis, hence its effect ofresisting relapse of chronic bronchitis.

  7. Effects of low level air pollution on asthma and chronic bronchitis in Nordic cities

    Energy Technology Data Exchange (ETDEWEB)

    Froesig, A.; Johnsen, C.R.; Vestergaard Pedersen, B.; Taudorf, E.

    1993-01-01

    This report summarizes information on the occurrence of the respiratory diseases asthma and chronic bronchitis in the Nordic countries and discusses differences in prevalence within and between these countries. The report also presents information on the active research groups working in the field, and reviews the current literature on relationships between low-level outdoor air pollution and asthma and bronchitis. The prevalence of asthma and of chronic bronchitis is 5 to 10% of the total population. Asthma alone accounts for 2 to 4% with no apparent national differences. Chronic bronchitis accounts for 3 to 5% in Norway, Sweden and Denmark, but is more frequent in Finland (around 10 to 15%). It has not been possible to estimate the prevalence of chronic bronchitis in Iceland from presently available studies. Based on differences in mortality rates it is believed that the prevalences in urban centres are up to about 50% higher than the national figures. The death rates for deaths attributed to asthma and chronic bronchitis show more distinct national differences, and increasing trends. These differences between countries and trends may be attributable to varying diagnostic practice. The occurrence of asthma in the Nordic countries is low compared to other Western industrialized countries. Independent studies have found that low to moderate air pollution levels influence the illness of subjects with respiratory diseases. However, there are still methodological problems to be solved in order to clarify the relationships in detail and to obtain reliable quantitative estimates of these relationships. Research in this area should be strengthened and scientific cooperation across boarders should be promoted. This necessitates an increased and co-ordinated allocation of research funds and a clarification of which authorities should have the responsibility for this area. (EG) (124 refs.)

  8. Treatment of Chronic Bronchitis with Modified Ma Xing Shi Gan Tang and Er Chen Tang

    Institute of Scientific and Technical Information of China (English)

    朱颖; 刘晓东

    2004-01-01

    @@ Chronic bronchitis is a disease commonly seen in the clinic. The authors have treated 78 cases of the disease with modified Ma Xing Shi Gan Tang (麻杏石甘汤 Decoction of Ephedra, Armeniacae Amarum, Glycyrrhizae and Gypsum Fibrosum) plus Er Chen Tang (二陈汤 Two Old Drugs Decoction). The results were satisfactory and reported as follows.

  9. The use of drug-free technologies in patients with chronic toxicochemical bronchitis

    Directory of Open Access Journals (Sweden)

    Illarionov V.E.

    2014-12-01

    Full Text Available Aim: development and scientific substantiation of a complex application halo-inhaled and flutter-kinesiotherapy in patients with chronic obstructive toxic chemical bronchitis. Material and methods. There was an examination and treatment of 125 patients with chronic obstructive toxic chemical bronchitis at the age from 32 to 65 years (average age 52.2+3,1 with industrial experience from 5 to 27 years (average age 15.9+3,9. Results. Comparative analysis revealed an advantage of an integrated application halo-inhaled and flutter-kinesiotherapy in patients with chronic obstructive toxic chemical bronchitis as in the I, and that is especially important at the II stage of the disease, which is confirmed by the regression of the main clinical symptoms, a significant decrease in the intensity index of inflammation, recovery to normal values of factors of local immunity broncho-pulmonary system. Conclusion. Developed a comprehensive program including halo-inhaled and flutter-kinesiotherapy in patients with chronic obstructive toxic chemical bronchitis has a pronounced anti-inflammatory, antibacterial and immunocorrection effect, improves bronchodilating function and bronchial obstruction in bronchial tubes of large, medium and small caliber. The absence of exacerbations in the past year proves that this method is highly effective secondary prevention of lung disease.

  10. Exposure to Outdoor Air Pollution and Chronic Bronchitis in Adults: A Case-Control Study

    Directory of Open Access Journals (Sweden)

    M Waked

    2012-09-01

    Full Text Available Background: Although Lebanon is a highly polluted country, so far no study has specifically been designed to assess the association between outdoor air pollution and chronic bronchitis in this country.Objective: To assess the association between exposure to outdoor air pollution and chronic bronchitis in Lebanon. Methods: A pilot case-control study was conducted in two tertiary care hospitals. Cases consisted of patients diagnosed with chronic bronchitis by a pulmonologist and those epidemiologically confirmed. Controls included individuals free of any respiratory signs or symptoms. After obtaining informed consent, a standardized questionnaire was administered.Results: Bivariate, stratified (over smoking status and gender and multivariate analyses revealed that passive smoking at home (ORa: 2.56, 95% CI: 1.73–3.80 and at work (ORa: 1.89, 95% CI: 1.13–3.17; older age (ORa: 1.75, 95% CI: 1.55–2.39; lower education (ORa: 1.44, 95% CI: 1.21–1.72; living close to a busy road (ORa: 1.95, 95% CI: 1.31– 2.89 and to a local power plant (ORa: 1.62, 95% CI: 1.07–2.45; and heating home by hot air conditioning (ORa: 1.85, 95% CI: 1.00–3.43 were moderately associated with chronic bronchitis; an inverse association was found with heating home electrically (ORa: 0.58, 95% CI: 0.39–0.85. A positive dose-effect relationship was observed in those living close to a busy road and to a local diesel exhaust source.Conclusion: Chronic bronchitis is associated with outdoor air pollution.

  11. Growth, Nutritional Status, and Pulmonary Function in Children with Chronic Recurrent Bronchitis.

    Science.gov (United States)

    Umławska, Wioleta; Lipowicz, Anna

    2016-01-01

    Bronchitis is a common health problem in children. Frequent bronchitis in infancy increases the risk of developing chronic respiratory diseases. The aim of the study was to assess the level of growth and the nutritional status in children and youths with special regard to the level of body fatness assessed by measuring skin-fold thickness. Relationships between somatic development, pulmonary function and the course of the disease were also explored. The study was carried out using anthropometric and spirometric measurements and also information on the severity and course of the disease in 141 children with chronic or recurrent bronchitis. All of the subjects were patients of the Pulmonary Medicine and Allergology Center in Karpacz, Poland. The mean body height did not differ significantly between the children examined and their healthy peers. However, the infection-prone children had excessive body fatness and muscle mass deficiency. The increased level of subcutaneous adipose tissue occurred especially in children with short duration of the disease, i.e. a maximum of 1 year. The functional lung parameters were generally normal. The presence of atopic diseases such as allergic rhinitis or atopic dermatitis did not impair the course of the children's somatic development. Also, long-term disease or the presence of additional allergic diseases did not impair lung function in the examined children. Taking appropriate preventive measures is recommended to achieve and maintain normal body weight in children who receive therapy due to bronchitis.

  12. Effect of smoking cessation on airway inflammation of rats with chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    LI Qing-yun; HUANG Shao-guang; WAN Huan-ying; WU Hua-cheng; ZHOU Tong; LI Min; DENG Wei-wu

    2007-01-01

    Background Smoking is the major cause of airway inflammation in chronic obstructive pulmonary disease (COPD),and smoking cessation is regarded as one of the important strategies for prevention and treatment of the inflammation.The inflammation of the chronic airway may be present and deteriorated even if the COPD patients stop smoking.Whether and how early smoking cessation affects the progress of inflammation is still obscure. This study was conducted to find the appropriate time for smoking cessation to terminate the airway inflammation in rats with smoke-induced chronic bronchitis.Methods A rat model of COPD was established by passively inhaling smoke mixture. Fifty-four young male Sprague-Dawley rats were randomly divided into 9 groups with different periods of smoke exposure and different time points of cessation. The inflammation markers to be detected included inflammatory cells in the bronchoalveolar lavage fluid (BALF), the myeloperoxidose (MPO) activity, the morphologic changes and the expression of ICAM-1 on the airway epithelium.Results When smoking was terminated at early stage, the inflammatory markers and related indexes were different from those of the typical chronic bronchitis group (group M7) (P<0.01). The pathologic score of group SC7 (2 weeks of smoking cessation after occurrence of typical chronic bronchitis ) was not different from that of group M7, and the level of ICAM-1 was still up-regulated (compared to group M7, P>0.05). Meanwhile, most of inflammatory cells in BALF were neutrophils compared to other groups (P<0.01).When smoking was terminated, the MPO activity was significantly lower than that of group M7 (P<0.01).Conclusions Smoking cessation at early stage can effectively inhibit the inflammatory reaction of COPD. Once chronic bronchitis occurs, little could be improved by smoking cessation.

  13. A community-based case-control study of asthma and chronic bronchitis in relation to occupation

    Energy Technology Data Exchange (ETDEWEB)

    Buchanan, D.; Donan, P.T.; Cowie, H.A.; Miller, B.G.; Soutar, C.A.

    1997-07-01

    A community-based epidemiological study was conducted in the West Lothian and Central Regions of Scotland in 1994 by postal questionnaire to investigate the associations between occupations previously held and prevalent symptoms of asthma and chronic bronchitis. 50% of the 34,000 questionnaires were returned. The prevalence of asthma was estimated to be 8% and that of chronic bronchitis was 15%. The prevalence of asthma and of chronic bronchitis related to work was estimated to be 0.5% and 2.2% respectively. Clinical assessments of a sample of respondents confirmed the reliability of diagnoses of asthma using a self-administered questionnaire, but suggested that the work-relatedness of asthma was less reliably diagnosed. Asthma symptoms were particularly implicated with employment in the food processing, catering and textiles industries. Chronic bronchitis symptoms were associated with dusty jobs such as coal mining metal processing and manufacturing of electrical products.

  14. Spirometric abnormalities associated with chronic bronchitis, asthma, and airway hyperresponsiveness among boilermaker construction workers

    Energy Technology Data Exchange (ETDEWEB)

    Hauser, R.; Eisen, E,A,; Pothier, L,; Lewis, D,; Bledsoe, T,; Christiani, D.C. [Harvard University, Boston, MA (United States). School of Public Health

    2002-06-01

    In a 2-year longitudinal study of boilermaker construction workers, authors found a significant association between working at oil-fired, coal-fired, and gas-fired industries during the past year and reduced lung function. In the present study, authors investigated whether chronic bronchitis, asthma, or baseline methacholine airway responsiveness can explain the heterogeneity in lung function response to boilermaker work. Exposure was assessed with a work history questionnaire. Spirometry was performed annually to assess lung function. A generalized estimating equation approach was used to account for the repeated-measures design. One hundred eighteen boilermakers participated in the study. Self-reported history of chronic bronchitis and asthma were associated with a larger FEV1 reduction in response to workplace exposure at coal-fired and gas-fired industries. Although a high prevalence (39%) of airway hyperresponsiveness (provocative concentration of methacholine causing a 20% fall in FEVI of {lt} 8 mg/mL) among boilermakers was found, there was no consistent pattern of effect modification by airway responsiveness. Conclusions: Although chronic bronchitis and asthma were associated with a greater loss in lung function in response to hours worked as a boilermaker, and therefore they acted as effect modifiers of the exposure-lung function relationship, airway hyperresponsiveness did not. However, the high prevalence of airway hyperresponsiveness found in the cohort may be a primary consequence of long-term workplace exposure among boilermakers.

  15. Increased Expression of the Calcium-Activated Chloride Channel in Hclca1 in Airways of Patients with Obstructive Chronic Bronchitis

    Directory of Open Access Journals (Sweden)

    Hans-Peter Hauber

    2005-01-01

    Full Text Available BACKGROUND: Interleukin (IL-9 and its effect on enhancing the human calcium-activated chloride channel 1 (hCLCA1 expression have been shown to induce mucin production. Increased expression of hCLCA1 may, in turn, contribute to mucus overproduction in chronic obstructive pulmonary disease (COPD with a chronic bronchitis (CB phenotype.

  16. Chronic Bronchitis

    Science.gov (United States)

    ... Situations Pets and Animals myhealthfinder Food and Nutrition Healthy Food Choices Weight Loss and Diet Plans Nutrients and Nutritional Info Sugar and Sugar Substitutes Exercise and Fitness Exercise Basics Sports Safety Injury Rehabilitation Emotional Well- ...

  17. Pro-Con Debate: Protracted Bacterial Bronchitis as a Cause of Chronic Cough in Children.

    Science.gov (United States)

    Bidiwala, Aneela; Krilov, Leonard R; Pirzada, Melodi; Patel, Sameer J

    2015-08-01

    Pro: Children with chronic cough present a diagnostic challenge. Protracted bacterial bronchitis (PBB) is a chronic, persistent bacterial infection of conducting airways defined by the presence of cough for longer than 4 weeks that resolves with antimicrobial therapy and without an alternative diagnosis. The diagnosis is made by the findings of increased bronchial secretions and edema of the lower airways on flexible bronchoscopy and positive cultures on bronchoalveolar lavage. It is speculated that an initial respiratory insult such as viral infection disrupts normal surface morphology and ciliary function, which leads to chronic self-perpetuating inflammation with the formation of bacterial biofilms, leading to PBB. PBB is often misdiagnosed as asthma, leading to inappropriate and excessive use of steroids. The importance of timely diagnosis should be emphasized due to the potential that PBB may be a precursor to chronic suppurative lung disease or bronchiectasis if left untreated; however, every patient should be adequately assessed to exclude other causes of chronic cough. Con: Clinical criteria for the diagnosis of PBB are nonspecific and may not distinguish it from other known causes of chronic cough, including viral infections. Benefits from antibiotic therapy (particularly prolonged therapy) have not been demonstrated. Respiratory conditions are the most common reason for antibiotic prescriptions during ambulatory visits in the United States, and many of these prescriptions are inappropriate and/or unnecessary. The proposed diagnostic criteria and recommendations for the treatment of PBB will lead to unnecessary overuse of antibiotics.

  18. Canadian Guidelines for the Management of Acute Exacerbations of Chronic Bronchitis

    Directory of Open Access Journals (Sweden)

    Meyer S Balter

    2003-01-01

    Full Text Available Acute exacerbations of chronic bronchitis (AECB account for over 1.5 million physician visits annually in Canada and are a cause of significant morbidity and mortality. This document represents a joint effort between respirologists, microbiologists, infectious disease specialists and family physicians to update the Canadian AECB guidelines published in 1994. Treatment recommendations are graded on the strength of evidence in the published literature where possible. The role for oral corticosteroid therapy in preventing treatment failures, speeding up recovery and delaying the time to next exacerbation is discussed. Risk factors for treatment failure were used to stratify patients into risk groups to help guide antibiotic treatment recommendations. The importance of emerging antimicrobial resistance to current antibiotics is reviewed and strategies to prevent future AECB episodes are suggested.

  19. The therapeutic efficacy of erdosteine in the treatment of chronic obstructive bronchitis: A meta-analysis of individual patient data

    OpenAIRE

    M. Cazzola; Floriani, I.; Page, C. P.

    2010-01-01

    Abstract Aim to test the available evidence for the efficacy of erdosteine in adults with stable or exacerbated CB/COPD. Erdosteine, a drug approved for the treatment of acute and chronic pulmonary diseases, has been shown to be an effective treatment for chronic bronchitis or COPD (CB/COPD) in several studies, although marked differences in the perception of its usefulness still remain. Methods meta-analysis of individual patient data fr...

  20. [Immediate and late results of rehabilitation at the climatic health resorts on the southern coast of the Crimea with sunlight- and meteorolabile patients with chronic bronchitis].

    Science.gov (United States)

    Logvionenko, I I; Sidorova, L D; Logvinenko, A S

    1988-01-01

    A study of the social, socioeconomic and economic indices of rehabilitation of patients with chronic obstructive and nonobstructive bronchitis has shown that one should take account of a degree of expression of heliometeolability when selecting patients with chronic bronchitis residing in West Siberia for climatic treatment in the Crimean South Coast. It has been shown that rehabilitation in the Crimean South Coast health resort area is advisable for heliometeostable patients and patients with mild and marked degrees of heliometeolability. Patients with chronic bronchitis should not be sent to the Crimea in winter and late autumn as the rehabilitation effect in this period is lowered.

  1. Protective effect of a bacterial extract against acute exacerbation in patients with chronic bronchitis accompanied by chronic obstructive pulmonary disease

    Institute of Scientific and Technical Information of China (English)

    李靖; 郑劲平; 袁锦屏; 曾广翘; 钟南山; 林材元

    2004-01-01

    Background Immunostimulating agents made from bacterial extracts represent a class of medications that contains antigens derived from several bacterial strains and their potential ability to prevent bacterial infections results from the stimulation of the nonspecific component of the immune system. The present study investigated the effect of the oral immunostimulant Broncho-Vaxom, which includes material from eight different species of bacteria that are frequently present in the lower respiratory tract, on the frequency and severity of acute exacerbation in patients with chronic bronchitis accompanied by chronic obstructive pulmonary disease (COPD). Methods Ninety patients with chronic bronchitis complicated with COPD were randomly divided into groups A and B. Forty-nine subjects in group A received oral capsules containing 7mg Broncho-Vaxom, while 41 patients in group B received similar placebo capsules. Both groups took one capsule daily for the first 10 days of each month for 3 consecutive months. The frequency of acute exacerbation, symptom scores, and lung function were recorded for the following one year period.Results There was a significant decrease in the incidence, duration, and severity of acute exacerbation, as well as a reduction in the course of antibiotics administered and in the dosage of bronchodilator and mucolytic agent in group A, as compared to group B (P<0.05, respectively). Symptom scores for cough, sputum, dyspnea, as well as symptoms observed upon auscultation of the chest also improved significantly in group A as compared to group B (P<0.05, respectively). The bacterial clearance rate in sputum cultures from patients who received no antibiotics for the first 3 months was also significantly higher in group A compared to group B (P<0.01).Conclusions Orally administered Broncho-Vaxom is associated with a decrease in the incidence of acute exacerbation and a decrease in the need for antibiotics and symptomatic relief medications in patients

  2. Economic burden of chronic bronchitis in the United States: a retrospective case-control study

    Directory of Open Access Journals (Sweden)

    Christopher M Blanchette

    2011-01-01

    Full Text Available Christopher M Blanchette1, Melissa H Roberts1, Hans Petersen1, Anand A Dalal2, Douglas W Mapel31Division of Clinical and Outcomes Research, Lovelace Respiratory Research Institute, Kannapolis, NC, USA; 2US Health Outcomes, GlaxoSmithKline, Research Triangle Park, NC, USA; 3Lovelace Clinic Foundation, Albuquerque, NM, USABackground: Chronic bronchitis (CB is often misdiagnosed or diagnosed at a later stage of chronic obstructive pulmonary disease (COPD. We examined how this later diagnosis may impact health care costs and utilization during the 12 months prior to and 24 months post initial CB diagnosis.Methods: This retrospective case-control analysis used claims data from a large US database from July 1, 2003 through June 30, 2007. Patients with CB aged 40 years and older were propensity matched (N = 11,674 to patients without evidence of COPD or asthma by demographics, CB diagnosis quarter/year, and comorbidities. Group differences were assessed using Student's t-test and Pearson chi-square test statistics.Results: Six months prediagnosis, CB patients had higher frequencies of any hospitalization (9.6%, 6.7%; P < 0.05, emergency department/urgent care visits (13.3%, 6.7%; P < 0.05, and prescriptions (97.3%, 94.1%; P < 0.05. Six months postdiagnosis, CB patients had 5.6 times more hospitalizations (P < 0.05 and 3.1 times more emergency department/urgent care visits (P < 0.05 compared with controls. Mean total costs (US$ for CB patients 12 months prediagnosis were significantly higher than controls (months 12–7: $4212, $3826; P < 0.05; months 6–1: $5289, $4285; P < 0.05. CB patients had higher mean total costs ($8919; P < 0.05 6 months postdiagnosis. Costs remained $2429 higher for CB patients 19–24 months postdiagnosis (P < 0.05.Conclusion: Health care costs and utilization among CB patients are increased both prior to diagnosis and during the 2 years postdiagnosis. This study suggests that not accurately diagnosing CB early has a

  3. [Occupational sanitary-and-hygienic conditions and chronic dust bronchitis morbidity in the ore-mining industry of Krivoi Rog region].

    Science.gov (United States)

    Gural', O I

    2005-01-01

    Chronic dust bronchitis morbidity of ore-mining workers is caused not only by high concentration of dust but also conditioned by carbon monoxide, nitric oxide, oil aerosols, unfavorable microclimate as well as different combinations of these adverse agents.

  4. Geo-climatic heterogeneity in self-reported asthma, allergic rhinitis and chronic bronchitis in Italy

    Energy Technology Data Exchange (ETDEWEB)

    Pesce, G., E-mail: giancarlo.pesce@univr.it [Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona (Italy); Bugiani, M. [Unit of Respiratory Medicine and Allergology, CPA-ASL TO-2, Turin (Italy); Marcon, A.; Marchetti, P. [Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona (Italy); Carosso, A. [Unit of Respiratory Medicine and Allergology, CPA-ASL TO-2, Turin (Italy); Accordini, S. [Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona (Italy); Antonicelli, L. [Dept of Internal Medicine, Immuno-Allergic and Respiratory Diseases, Ospedali Riuniti di Ancona, Ancona (Italy); Cogliani, E. [Casaccia Research Centre, Italian National Agency for New Technologies, Energy, and Substainable Economic Development (ENEA), Rome (Italy); Pirina, P. [Institute of Respiratory Diseases, University of Sassari, Sassari (Italy); Pocetta, G. [Dept of Experimental Medicine, University of Perugia, Perugia (Italy); Spinelli, F. [Casaccia Research Centre, Italian National Agency for New Technologies, Energy, and Substainable Economic Development (ENEA), Rome (Italy); Villani, S. [Dept of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia (Italy); Marco, R. de [Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona (Italy)

    2016-02-15

    Background: Several studies highlighted a great variability, both between and within countries, in the prevalence of asthma and chronic airways diseases. Aim: To evaluate if geo-climatic variations can explain the heterogeneity in the prevalence of asthma and respiratory diseases in Italy. Methods: Between 2006 and 2010, a postal screening questionnaire on respiratory health was administered to 18,357 randomly selected subjects, aged 20–44, living in 7 centers in northern, central, and southern Italy. A random-effects meta-analysis was fitted to evaluate the between-centers heterogeneity in the prevalence of asthma, asthma-like symptoms, allergic rhinitis, and chronic bronchitis (CB). A principal component analysis (PCA) was performed to synthetize the geo-climatic information (annual mean temperature, range of temperature, annual rainfalls, global solar radiations, altitude, distance from the sea) of all the 110 Italian province capital towns. The associations between these geo-climatic components obtained with PCA and the prevalence of respiratory diseases were analyzed through meta-regression models. Results: 10,464 (57%) subjects responded to the questionnaire. There was a significant between-centers heterogeneity in the prevalence of asthma (I{sup 2} = 59.5%, p = 0.022) and CB (I{sup 2} = 60.5%, p = 0.019), but not in that of asthma-like symptoms or allergic rhinitis. Two independent geo-climatic components explaining together about 80% of the overall geo-climatic variability were identified: the first principally summarized the climatic variables; the second the topographic ones. Variations in the prevalence of asthma across centers were significantly associated with differences in the climatic component (p = 0.017), but not with differences in the topographic one. Conclusions: Our findings suggest that climate play a role in determining the between-center heterogeneity in the prevalence of asthma in Italy, with higher prevalence in dry-hot Mediterranean

  5. Acute Bronchitis

    Science.gov (United States)

    ... Smoking also slows down the healing process. Acute bronchitis treatment Most cases of acute bronchitis can be treated at home.Drink fluids, but ... bronchial tree. Your doctor will decide if this treatment is right for you. Living with acute bronchitis Most cases of acute bronchitis go away on ...

  6. Activity of erdosteine on mucociliary transport in patients affected by chronic bronchitis.

    Science.gov (United States)

    Olivieri, D; Del Donno, M; Casalini, A; D'Ippolito, R; Fregnan, G B

    1991-01-01

    The influence of erdosteine (a mucomodulator endowed with mucolytic and antioxidant properties) on human mucociliary transport (MCT) was investigated in a double-blind placebo controlled study. Sixteen former smokers affected by chronic bronchitis, preselected for their mucociliary responsiveness to an inhaled beta 2-agonist, were divided into two groups (matched by number, sex, age and FEV1%) and orally treated with placebo or erdosteine (300 mg t.i.d.) for 8 days. Their MCT was assessed by the bronchofiberscopy technique just before starting the treatment and at the end of the treatment. The pretreatment mucus transport velocity in these patients was significantly decreased with respect to healthy subjects. The erdosteine treatment induced a significant improvement of MCT while placebo was inactive (mean % variation +/- SE against their baseline values being +60.4 +/- 18.4 and -3.0 +/- 5.9, respectively). This peculiar activity of erdosteine on mucus transport may be of clinical usefulness in chronic bronchitic patients and it can be added to beta 2-agonist to restore the decreased MCT.

  7. Effect of inhaled procaterol on cough receptor sensitivity to capsaicin in patients with asthma or chronic bronchitis and in normal subjects.

    OpenAIRE

    Fujimura, M; Sakamoto, S.; Kamio, Y.; Bando, T.; Kurashima, K.; T. Matsuda

    1993-01-01

    BACKGROUND--To evaluate the effect of inhaled beta 2 adrenergic agonists on the sensitivity of airway cough receptors, the effect of inhaled procaterol on cough induced by aerosolised capsaicin, a stimulant of C fibres, was studied in patients with asthma or chronic bronchitis and in normal subjects. METHOD--Eleven patients with asthma and 10 with chronic bronchitis and 14 normal subjects participated. Increasing concentrations of capsaicin solution were inhaled for 15 seconds by tidal breath...

  8. Influence of erdosteine, a mucolytic agent, on amoxycillin penetration into sputum in patients with an infective exacerbation of chronic bronchitis.

    Science.gov (United States)

    Ricevuti, G; Mazzone, A; Uccelli, E; Gazzani, G; Fregnan, G B

    1988-08-01

    Twenty four patients with acute infective exacerbations of chronic bronchitis received amoxycillin alone or in combination with erdosteine (a mucolytic agent) for a week in a double blind, placebo controlled study. Clinical assessment scores, body temperature, serum and sputum amoxycillin concentrations, and sputum culture results were recorded in each group. Erdosteine significantly increased antibiotic concentrations in sputum but not in serum. The combined treatment also caused a more rapid decrease in sputum viscosity and in body temperature and faster sterilisation of the sputum. These results show that erdosteine increases amoxycillin concentration in sputum in patients with acute exacerbations of chronic bronchitis. This effect may be due to a reduction in the viscosity of the bronchial secretions produced by erdosteine.

  9. Influence of erdosteine, a mucolytic agent, on amoxycillin penetration into sputum in patients with an infective exacerbation of chronic bronchitis.

    OpenAIRE

    Ricevuti, G; Mazzone, A.; Uccelli, E.; G. Gazzani; Fregnan, G. B.

    1988-01-01

    Twenty four patients with acute infective exacerbations of chronic bronchitis received amoxycillin alone or in combination with erdosteine (a mucolytic agent) for a week in a double blind, placebo controlled study. Clinical assessment scores, body temperature, serum and sputum amoxycillin concentrations, and sputum culture results were recorded in each group. Erdosteine significantly increased antibiotic concentrations in sputum but not in serum. The combined treatment also caused a more rapi...

  10. 慢性支气管炎的临床护理%Clinical Nursing in Treating Patients with Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    张文娟

    2015-01-01

    Objective To probe into the nursing measures for patients with chronic bronchitis. Methods 89 cases of chronic bronchitis patients received by our hospital, given conventional treatment and targeted comprehensive care, observe the ef ect. Results After reasonable treatment and good nursing , al patients had good ef ect. Conclusion To employ conventional treatment and targeted care for patients , can reduce the incidence of complications and the recurrence rate of chronic bronchitis , increase the cure and quality of life of the patients.%目的探讨临床护理干预在慢性支气管炎治疗中的作用。方法对89例慢性支气管炎患者的临床资料进行分析,讨论根据患者特点采用有针对性的护理措施。结果正确的护理措施对患者的治疗,取得了良好的效果。结论在慢性支气管炎的治疗中,采用有针对性的护理措施,可以有效降低疾病的复发,促进患者的康复。

  11. Whether chronic bronchitis is an independent risk factor for cerebral infarction in the elderly 1:1 case paired study

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    BACKGROUND: The inflammatory reaction already becomes an important risk factor of causing acute cerebral infarction; however, the correlation between chronic bronchitis and senile cerebral infarction is still unclear.OBJECTIVE: To study whether the chronic bronchitis is the risk factor for senile cerebral infarction.DESIGN: 1:1 pair, case contrast, and risk factor study.SETTINGS: Department of Respiratory Medicine, Third Hospital of Tangshan; Department of Neurology,Affiliated Hospital of North China Coal Medical College.PARTICIPANTS: A total of 147 patients with acute cerebral infarction who were regarded as case group were selected from Department of Neurology, the Third Hospital of Tangshan from January 2004 to December 2006. All patients met the diagnostic criteria of the Fourth National Cerebrovascular Diseases Meeting. There were 87 males and 60 females, and their ages ranged from 65 to 83 years. Based on 1∶1 pair study, another 147 subjects without cerebrovascular disease were regarded as control group. Except the diseases about infection, there were 73 males and 74 females, and their ages ranged from 62 to 81 years. All subjects provided the confirm consent and agreed with the coordinate experiment.METHODS: ① Questionnaire of risk factor of cerebral infarction was designed to measure the following items: chronic bronchitis, hypertension, diabetes mellitus, hyperlipemia, coronary heart disease, primary cerebral infarction/transient ischemic attack and history of smoking. ② Cerebral infarction was regarded as the dependent variance, while chronic bronchitis, hypertension, diabetes mellitus, hyperiipemia, primary cerebral infarction/transient ischemic attack, coronary heart disease and smoking were regarded as the independent variance for multiple regression analysis.MAIN OUTCOME MEASURES: Risk factors of senile cerebral infarction.RESULTS: All 147 patients with acute cerebral infarction and 147 subjects without cerebrovascular diseases were involved in

  12. [Hemodynamics, blood gas composition and viscosity in patients with chronic obstructive bronchitis complicated by chronic cor pulmonale].

    Science.gov (United States)

    Verbitskiĭ, O N; Buturov, I V; Purkh, T Iu; Mohamed Fadi Fanari; Paraska, V I

    2004-01-01

    Hemodynamics, external respiratory function (ERF), blood gas composition and viscosity were studied in 120 patients with chronic obstructive bronchitis at different developmental stage of cor pulmonale. In pulmonary hypertension, there were moderate ERF disorders that became more marked in the compensatory and particularly decompensatory cor pulmonale. As bronchial patency deteriorated, the index of right ventricular performance increased from 0.76+0.081 to 1.23+0.022 in the examinees. Examination of blood gas composition revealed insignificant hypoxemia in pulmonary hypertension and compensatory cor pulmonale, which progressed with decompensation of chronic cor pulmonale (CCP). As bronchial obstruction progressed, there were increases in systolic, diastolic, and mean pressure in the pulmonary artery. The viscosity of blood and plasma and the indices of red blood cell aggregation and deformability were in the normal range in pulmonary hypertension and compensatory CCP. In CCP decompensation, the viscosity of blood and plasma and the index of red blood cell aggregation were increased and the index of red blood cell deformability was decreased.

  13. Network pharmacology-based identification of key pharmacological pathways of Yin–Huang–Qing–Fei capsule acting on chronic bronchitis

    Science.gov (United States)

    Yu, Guohua; Zhang, Yanqiong; Ren, Weiqiong; Dong, Ling; Li, Junfang; Geng, Ya; Zhang, Yi; Li, Defeng; Xu, Haiyu; Yang, Hongjun

    2017-01-01

    For decades in China, the Yin–Huang–Qing–Fei capsule (YHQFC) has been widely used in the treatment of chronic bronchitis, with good curative effects. Owing to the complexity of traditional Chinese herbal formulas, the pharmacological mechanism of YHQFC remains unclear. To address this problem, a network pharmacology-based strategy was proposed in this study. At first, the putative target profile of YHQFC was predicted using MedChem Studio, based on structural and functional similarities of all available YHQFC components to the known drugs obtained from the DrugBank database. Then, an interaction network was constructed using links between putative YHQFC targets and known therapeutic targets of chronic bronchitis. Following the calculation of four topological features (degree, betweenness, closeness, and coreness) of each node in the network, 475 major putative targets of YHQFC and their topological importance were identified. In addition, a pathway enrichment analysis based on the Kyoto Encyclopedia of Genes and Genomes pathway database indicated that the major putative targets of YHQFC are significantly associated with various pathways involved in anti-inflammation processes, immune responses, and pathological changes caused by asthma. More interestingly, eight major putative targets of YHQFC (interleukin [IL]-3, IL-4, IL-5, IL-10, IL-13, FCER1G, CCL11, and EPX) were demonstrated to be associated with the inflammatory process that occurs during the progression of asthma. Finally, a molecular docking simulation was performed and the results exhibited that 17 pairs of chemical components and candidate YHQFC targets involved in asthma pathway had strong binding efficiencies. In conclusion, this network pharmacology-based investigation revealed that YHQFC may attenuate the inflammatory reaction of chronic bronchitis by regulating its candidate targets, which may be implicated in the major pathological processes of the asthma pathway. PMID:28053519

  14. Nursing experience of chronic bronchitis%浅谈慢性支气管炎的护理体会

    Institute of Scientific and Technical Information of China (English)

    费亚芬

    2014-01-01

    Objective: To investigate the nursing effect of patients with chronic bronchitis. Methods: in our hospital from 2012 March to 2014 January were treated 100 patients with chronic bronchitis, given clinical observation, mental nursing, medication nursing, life care, health care guidance. Results: in 100 cases of chronic bronchitis patients in this group, after the treatment and nursing of 86 patients after, markedly effective (86%), effective 12 cases (12%), 2 cases of invalid patients (2%), the total efficiency is 98%, no serious complications. Conclusion: for the patients of chronic bronchitis, by giving the scientific comprehensive nursing, conducive to patient recovery, reduce the incidence of complications, improve the quality of life of patients.%目的:探讨慢性支气管炎患者的护理效果。方法我院从2012年3月到2014年1月共收治慢性支气管炎患者100例,给予临床观察、心理护理、用药护理、生活护理、健康指导等护理。结果在本组的100例慢性支气管炎患者中,经过治疗与护理之后,显效的患者86例(86%),有效的患者12例(12%),无效的患者2例(2%),总有效率是98%,均没有严重的并发症。结论对于慢性支气管炎患者,通过给予全方面的科学护理,有利于患者的病情早日康复,降低并发症的发生率,提高患者的生存质量。

  15. Plastic bronchitis

    Directory of Open Access Journals (Sweden)

    Anil Kumar Singhi

    2015-01-01

    Full Text Available Plastic bronchitis, a rare but serious clinical condition, commonly seen after Fontan surgeries in children, may be a manifestation of suboptimal adaptation to the cavopulmonary circulation with unfavorable hemodynamics. They are ominous with poor prognosis. Sometimes, infection or airway reactivity may provoke cast bronchitis as a two-step insult on a vulnerable vascular bed. In such instances, aggressive management leads to longer survival. This report of cast bronchitis discusses its current understanding.

  16. Current asthma contributes as much as smoking to chronic bronchitis in middle age: a prospective population-based study

    Directory of Open Access Journals (Sweden)

    Dharmage SC

    2016-08-01

    Full Text Available Shyamali C Dharmage,1 Jennifer L Perret,1,2, John A Burgess,1 Caroline J Lodge,1 David P Johns,3 Paul S Thomas,4 Graham G Giles,1,5 John L Hopper,1,6 Michael J Abramson,7,8 E Haydn Walters,3,9, Melanie C Matheson1 1Allergy and Lung Health Unit, Center for Epidemiology and Biostatistics, The University of Melbourne, 2Institute for Breathing and Sleep (IBAS, Melbourne, VIC, 3“Breathe Well” Center of Research Excellence for Chronic Respiratory Disease and Lung Ageing, School of Medicine, University of Tasmania, Hobart, TAS, 4Inflammation and Infection Research, Faculty of Medicine, University of New South Wales, Sydney, NSW, 5Cancer Epidemiology Center, Cancer Council Victoria, Melbourne, VIC, Australia; 6Department of Public Health, Seoul National University, Seoul, South Korea; 7Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, 8School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 9School of Medicine, University of Tasmania, Hobart, TAS, Australia Background and objective: Personal smoking is widely regarded to be the primary cause of chronic bronchitis (CB in adults, but with limited knowledge of contributions by other factors, including current asthma. We aimed to estimate the independent and relative contributions to adult CB from other potential influences spanning childhood to middle age.Methods: The population-based Tasmanian Longitudinal Health Study cohort, people born in 1961, completed respiratory questionnaires and spirometry in 1968 (n=8,583. Thirty-seven years later, in 2004, two-thirds responded to a detailed postal survey (n=5,729, from which the presence of CB was established in middle age. A subsample (n=1,389 underwent postbronchodilator spirometry between 2006 and 2008 for the assessment of chronic airflow limitation, from which nonobstructive and obstructive CB were defined. Multivariable and multinomial logistic regression models were used to estimate

  17. Bronchitis and Pneumonia

    Science.gov (United States)

    ... by a health care provider. How serious are bronchitis and pneumonia? Both conditions are more serious if a child has a chronic health condition or if the condition is caused by a bacteria, in which case antibiotics are the treatment of choice. When pneumonia is caused by bacteria, ...

  18. Urinary polyaromatic hydrocarbons are associated with adult emphysema, chronic bronchitis, asthma, and infections: US NHANES, 2011-2012.

    Science.gov (United States)

    Shiue, Ivy

    2016-12-01

    Links between environmental chemicals and human health have emerged over the last few decades, but the effects from polyaromatic hydrocarbons were less studied, compared to other commonly known environmental chemicals such as heavy metals, phthalates, arsenic, phenols, pesticides, etc. Therefore, the aim of the study was to examine the relationships of urinary polyaromatic hydrocarbons and adult respiratory health conditions using a large human sample in a national and population-based setting in recent years. Data were retrieved from United States National Health and Nutrition Examination Surveys, 2011-2012 including demographics, self-reported health conditions, and urinary polyaromatic hydrocarbons. Statistical analyses including chi-square test, t test, and survey-weighted logistic regression modeling were performed. Of 5560 American adults aged 20-80, urinary 2-hydroxyfluorene and 3-hydroxyfluorene were positively associated with emphysema (OR, 1.60, 95 % CI 1.26 to 2.03, P = 0.001 and OR, 1.42, 95 % CI 1.15 to 1.77, P = 0.003, respectively) and chronic bronchitis (OR, 1.42, 95 % CI 1.04 to 1.94, P = 0.031 and OR, 1.40, 95 % CI 1.03 to 1.91, P = 0.036, respectively), while 2-hydroxynaphthalene (2-naphthol) was likely to be borderline associated with emphysema and chronic bronchitis. Conversely, urinary 1-hydroxyphenanthrene, 3-hydroxyphenanthrene, 1-hydroxypyrene, and 4-hydroxyphenanthrene were inversely associated with asthma and infections. Urinary polyaromatic hydrocarbons are associated with adult respiratory health conditions, although the causality cannot be established. For future research, studies using large human sample across regions to longitudinally monitor would be suggested. For practice and policy-making, regulation on minimizing polyaromatic hydrocarbons exposure to protect respiratory health might need to be considered in future health and environmental policies and intervention programs.

  19. Traffic-related air pollution associated with prevalence of asthma and COPD/chronic bronchitis. A cross-sectional study in Southern Sweden

    Directory of Open Access Journals (Sweden)

    Nihlén Ulf

    2009-01-01

    Full Text Available Abstract Background There is growing evidence that air pollution from traffic has adverse long-term effects on chronic respiratory disease in children, but there are few studies and more inconclusive results in adults. We examined associations between residential traffic and asthma and COPD in adults in southern Sweden. A postal questionnaire in 2000 (n = 9319, 18–77 years provided disease status, and self-reported exposure to traffic. A Geographical Information System (GIS was used to link geocoded residential addresses to a Swedish road database and an emission database for NOx. Results Living within 100 m of a road with >10 cars/minute (compared with having no heavy road within this distance was associated with prevalence of asthma diagnosis (OR = 1.40, 95% CI = 1.04–1.89, and COPD diagnosis (OR = 1.64, 95%CI = 1.11–2.4, as well as asthma and chronic bronchitis symptoms. Self-reported traffic exposure was associated with asthma diagnosis and COPD diagnosis, and with asthma symptoms. Annual average NOx was associated with COPD diagnosis and symptoms of asthma and chronic bronchitis. Conclusion Living close to traffic was associated with prevalence of asthma diagnosis, COPD diagnosis, and symptoms of asthma and bronchitis. This indicates that traffic-related air pollution has both long-term and short-term effects on chronic respiratory disease in adults, even in a region with overall low levels of air pollution.

  20. Plastic Bronchitis.

    Science.gov (United States)

    Rubin, Bruce K

    2016-09-01

    Plastic bronchitis is an uncommon and probably underrecognized disorder, diagnosed by the expectoration or bronchoscopic removal of firm, cohesive, branching casts. It should not be confused with purulent mucous plugging of the airway as seen in patients with cystic fibrosis or bronchiectasis. Few medications have been shown to be effective and some are now recognized as potentially harmful. Current research directions in plastic bronchitis research include understanding the genetics of lymphatic development and maldevelopment, determining how abnormal lymphatic malformations contribute to cast formation, and developing new treatments.

  1. Cefditoren versus levofloxacin in patients with exacerbations of chronic bronchitis: serum inflammatory biomarkers, clinical efficacy, and microbiological eradication

    Directory of Open Access Journals (Sweden)

    Blasi F

    2013-02-01

    Full Text Available Francesco Blasi, Paolo Tarsia, Marco Mantero, Letizia C Morlacchi, Federico PifferDepartment of Pathophysiology and Transplantation, University of Milan, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Milan, ItalyBackground: The aim of this open-label, randomized, parallel-group pilot study was to evaluate the efficacy of cefditoren pivoxil and levofloxacin in terms of speed of reduction in inflammatory parameters, clinical recovery, and microbiological eradication.Methods: Forty eligible patients with acute exacerbation of chronic bronchitis (AECB were randomized to receive cefditoren 200 mg twice a day for 5 days (n = 20 or levofloxacin 500 mg once daily for 7 days (n = 20.Results: The inflammatory parameters which were significantly reduced at test-of-cure with respect to visit 1 were Krebs von den Lundgen-6 (KL-6 and interleukin-6. KL-6 decreased both in the overall study population (from 19 ± 11 UI/mL to 6 ± 8 UI/mL, P = 0.000 and in the cefditoren (from 19 ± 13 UI/mL to 8 ± 10 UI/mL, P = 0.006 and levofloxacin (from 19 ± 10 UI/mL to 5 ± 5 UI/mL, P = 0.000 arms. Similarly, interleukin-6 decreased both in the overall study population (from 13.35 ± 16.41 pg/mL to 3 ± 4.7 pg/mL, P = 0.000 and in the cefditoren (from 15.90 ± 19.54 pg/mL to 4.13 ± 6.42 pg/mL, P = 0.015 and levofloxacin (from 10.80 ± 12.55 pg/mL to 1.87 ± 1.16 pg/mL, P = 0.003 arms. At the end of treatment (test-of-cure, 6–9 days after drug initiation, the clinical success rate in the overall study population was 78%; the clinical cure rate was 80% in the cefditoren arm and 75% in the levofloxacin arm. Globally, bacteriological eradication at test-of-cure was obtained in 85% of the overall study population. Both treatments were well tolerated.Conclusion: Cefditoren represents a valid option in the treatment of mild to moderately severe cases of AECB in the outpatient care setting. Moreover, the use of this cephalosporin is associated with a significant

  2. 慢性支气管炎中医治疗体会%The Experience of the Treatment of Chronic Bronchitis With Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    靖春梅

    2015-01-01

    Objective To study the clinical effect of chronic bronchitis treated with Traditional Chinese Medicine. Method Analysed the clinical treatment data of thirty-ifve cases of chronic bronchitis patients treated by Traditional Chinese Medicine from 2012 to 2013 in our hospital. Results 19 cases were markedly effective, 11 cases were effective, and the total efifciency reach to 85.7%. Conclusion The Traditional Chinese Medicine used in the treatment of chronic bronchitis patients can have a satisfactory effect, and reduce the recurrence rate.%目的:探讨慢性支气管炎的中医治疗方法。方法选取2012~2013年收治的慢性支气管炎患者35例的临床中医治疗资料进行分析。结果本组收治的35例患者中,显效19例,有效11例,总有效率85.7%。结论对慢性支气管炎患者进行中医论治效果满意,可降低复发率。

  3. 慢性支气管炎的临床治疗体会%To Discuss Clinical Experience on Treatment of Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    姚运清

    2015-01-01

    目的:探讨慢性支气管炎的治疗体会。方法回顾性分析我院2013年3月~8月收治的58例慢性支气管炎患者。结果经治疗后,治愈48例,有显著效果的8例,好转1例,无效1例。结论早发现、早治疗是治疗慢性支气管炎的主要方法。%Objective To investigate the treatment of chronic bronchitis. Methods A retrospective analysis of 58 cases of patients with chronic bronchitis treated in our hospital from March 2013 to August 2013.Results After treatment, 48 cases were cured, 8 cases with signiifcant effect, one case with improvement , one case invalid .Conclusion Early detection and early treatment is the main method for the treatment of chronic bronchitis.

  4. Aclidinium bromide inhalation powder for the long-term, maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease including chronic bronchitis and emphysema.

    Science.gov (United States)

    Matera, Maria Gabriella; Sanduzzi, Alessandro; Alfano, Roberto; Cazzola, Mario

    2016-06-01

    Aclidinium is a twice-daily long-acting muscarinic receptor antagonist (LAMA) with an interesting pharmacological profile. Recent evidence indicates that this LAMA, in addition to causing a significant improvement in lung function and other important supportive outcomes, such as health related quality of life, dyspnea and nighttime/early morning symptoms in patients suffering from COPD, is also able to significantly reduce the rate of exacerbations of any severity, is extremely effective in controlling the COPD symptoms, is able to reduce lung hyperinflation, and has an excellent cardiovascular safety profile. Consequently, aclidinium should be considered a first-line approach at least for the symptomatic treatment of COPD although there are still few head-to-head studies comparing this LAMA with other bronchodilators. In any case, aclidinium can be taken into account in the treatment of different COPD phenotypes (emphysema, chronic bronchitis, exacerbators and patients with overlap COPD asthma).

  5. Evaluation of efficacy and safety of erdosteine in patients affected by chronic bronchitis during an infective exacerbation phase and receiving amoxycillin as basic treatment (ECOBES, European Chronic Obstructive Bronchitis Erdosteine Study).

    Science.gov (United States)

    Marchioni, C F; Polu, J M; Taytard, A; Hanard, T; Noseda, G; Mancini, C

    1995-11-01

    An international multicentric study was conducted with the aim of demonstrating that erdosteine improves the efficacy of amoxycillin in the treatment of infective exacerbation of chronic bronchitis mainly on the clinical symptomatology (primary objective), on spirometric tests and body temperature, without negatively influencing the tolerance (secondary objectives). The study was conducted as a prospective evaluation, with 2 comparative groups treated with erdosteine (300 mg x 2/day) or placebo in association with amoxycillin (1500 mg/day) for a maximum of 10 days. The design of the trial was double-blind and parallel group with 2 subgroups. The treatments have been assigned randomly to a population of chronic bronchitic patients in exacerbation phase of n = 237 subjects. The study was conducted according to the principles of the Declaration of Helsinki and its amendments (Hong Kong, September 1989). The primary end-point used to determine effectiveness in this study was the global clinical assessment (GCA) which was choosen as a general indication of activity with objective/subjective evaluation of the clinical picture. Secondary endpoints of efficacy are sputum parameters, functional signs of chronic obstructive bronchitis, spirometric tests and overall judgement of efficacy. Safety was evaluated with adverse drug reactions reporting, arterial blood pressure, heart rate and laboratory tests monitoring. The obtained values have been analyzed with two-way and factorial ANOVA, Least Squares Catmod-SAS, Wilcoxon and Chi-square tests. The number of patients included in the effectiveness analysis is of n = 226 subjects, due to the fact that 11 patients were lost due to different reasons. In term of results as far as the primary objective of the study was concerned, erdosteine resulted more active than placebo. The analysis evidenced a very significant difference for treatment, time and interaction time x treatment. No difference on the contrary was observed for center

  6. [Multicenter, controlled, double-blind study of the efficacy and tolerance of Vectrine (erdostein) versus placebo in the treatment of stabilized chronic bronchitis with hypersecretion].

    Science.gov (United States)

    Aubier, M; Berdah, L

    1999-09-01

    The clinical efficacy of vectrine (erdosteine) was evaluated in the treatment of chronic bronchitis patients with hypersecretion during a controlled clinical trial having included 170 patients. For inclusion, the bronchitis patients had to be in a stable status (no exacerbation since at least three months). The patients received, in double-blind protocol, vectrine, one capsule b.i.d. or placebo, one similar capsule b.i.d. during a period treatment of 21 days. The results of the main evaluation criteria, the global index of efficacy (frequency of the cough + severity of the cough + difficulty in breathing + dyspnea) but also on the intensity and frequency of the cough were statistically significant in favor of vectrine. The safety of the treatment was excellent.

  7. Plastic bronchitis: a management challenge.

    Science.gov (United States)

    Eberlein, Michael H; Drummond, Michael B; Haponik, Edward F

    2008-02-01

    Plastic bronchitis is an uncommon and underdiagnosed entity, characterized by recurrent expectoration of large, branching bronchial casts. We describe a 39-year-woman with no prior lung disease who had episodic wheezing, severe dyspnea with expectoration of large and thick secretions, branching in appearance, which she described as resembling squid. A comprehensive evaluation revealed no specific cause and a diagnosis of idiopathic plastic bronchitis was made. In plastic bronchitis the bronchial casts may vary in size from small segmental casts of a bronchus to casts filling the airways of an entire lung. Plastic bronchitis can therefore present as an acute life-threatening emergency if mechanical obstruction of major airways occurs. The casts are differentiated into type I, inflammatory casts, or type II, acellular casts. The type I inflammatory casts are often associated with bronchial disease and often have an acute presentation. The acellular type of cast production is often chronic or recurrent. Numerous systemic illnesses are associated with plastic bronchitis, but often, as in our patient, no underlying cause can be identified. The treatment of plastic bronchitis includes acute therapy to aid the removal and expectoration of casts, and specific short- or long-term treatments attempting to address the underlying hypersecretory process. The therapeutic options are supported only by anecdotal evidence based on case reports as the rarity and heterogeneity of plastic bronchitis confounds systematic investigations of its treatment. Improved understanding of the regulation of mucus production may allow for new treatment options in plastic bronchitis and other chronic lung diseases characterized by hypersecretion of mucus.

  8. What Causes Bronchitis?

    Science.gov (United States)

    ... Public » Health Topics » Bronchitis » What Causes Bronchitis? Explore Bronchitis What Is... Other Names Causes Who Is at Risk Signs & Symptoms Diagnosis Treatments Prevention Living With Clinical Trials Links Related Topics ...

  9. 崔应珉教授治疗慢性支气管炎经验%Experience of Professor Cui Yingmin in the Treatment of Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    张珂

    2013-01-01

    Objective:To summarize the experience of Professor Cui Yingmin in the treatment of chronic bronchitis. Methods: Based on chronic bronchitis cases treated by Professor Cui Yingmin,to analyze and summarize the dialectical thought and clinical experiences. Results: Professor Cui Yingmin regarded chronic bronchitis was deficiency for the fundamental reason and excess in manifestation, with lung,spleen and kidney for the deficiency,while phlegm and blood stasis as the manifestation. Clinical treatment was acute exacerbation of chronic,with remission and delayed treatment by stage,with the modification of Shegan Mahuang soup,Yuebi Jiazhu soup,Sanzi Yan-gqin soup, Buzhong Yiqi soup, Erchen soup, Shashen Maidong soup. The clinical curative effect was marked. Conclusion: Professor Cui Yingmin argues that chronic bronchitis is an easily relapsed and refractory disease,in clinical it should be treated by stages by taking care of the fundermental causes and manifestations, which provides some clinical reference.%目的:探讨崔应珉教授治疗慢性支气管炎经验.方法:以崔应珉教授治疗慢性支气管炎验案为依据,分析总结其辨证思路及临证经验.结果:崔应珉教授针对慢性支气管炎多为本虚标实这一特点,以肺、脾、肾三脏亏虚为本,痰浊、瘀血为标,临床施治多以急性加重期、慢性缓解期与迁延期分期论治,以射干麻黄汤、越婢加术汤、三子养亲汤、补中益气汤、二陈汤、沙参麦冬汤等灵活化裁,临床疗效显著.结论:崔应珉教授认为慢性支气管炎是一种易复发难治性疾病,临床采用分期辨治,标本兼顾,可资临床参考.

  10. Otras enfermedades obstructivas: bisinosis, bronquitis crónica y EPOC de origen laboral y bronquitis eosinofílica Other obstructive diseases: byssinosis, chronic bronchitis and occupational COPD and eosinophilic bronchitis

    Directory of Open Access Journals (Sweden)

    F. J. Michel De la Rosa

    2005-01-01

    Full Text Available Además del asma ocupacional y las enfermedades derivadas de la inhalación aguda, otras enfermedades obstructivas también reconocen un origen laboral. Aunque en la actualidad la bisinosis es una enfermedad rara en España, describimos las características de la misma por su interés histórico dentro de las enfermedades respiratorias de origen laboral y porque todavía sigue vigente en los países en vías de desarrollo. La bronquitis crónica también puede estar relacionada con la exposición laboral a polvos y humos, con frecuencia denominada "bronquitis industrial". La relación ocupacional de la EPOC ha sido más controvertida a lo largo de la historia, pero en la actualidad esta relación está aceptada; describimos la evidencia actual que sustenta esta relación. En último lugar, describimos la bronquitis eosinofílica sin asma, entidad descrita por primera vez en 1989 y que en ocasiones también puede tener un origen laboral, compartiendo agentes etiológicos con el asma ocupacional.Besides occupational asthma and diseases derived from acute inhalation, other obstructive diseases also have an occupational origin. Although at present byssinosis is a rare disease in Spain, we describe its characteristics because of its historical interest amongst occupational respiratory diseases and because it is still relevant in developing countries. Chronic bronchitis can also be related to exposure at work to dust and smoke, and is often referred to as "industrial bronchitis". Historically, the relation of CPOD to occupation has been subject to controversy, but nowadays this relationship is accepted; we describe the present evidence supporting this relationship. Finally, we describe eosinophilic bronchitis without asthma, an entity that was described for the first time in 1989 and that can sometimes have an occupational origin, sharing aetiological agents with occupational asthma.

  11. 慢性支气管炎呼吸内科规范治疗体会%Chronic bronchitis,respiratory medicine specification treatment experience

    Institute of Scientific and Technical Information of China (English)

    王瑾瑜

    2014-01-01

    Objective To analysis using respiratory medicine in patients with chronic bronchitis clinical value and safety of treatment. Methods Randomly selected 80 cases of chronic bronchitis patients as the research object,the control group 40 cases were treated by conventional solution treatment; The experimental group 40 cases were treated by respiratory medicine standard treatment for treatment. Results The patients clinical total effective rate was 95.00%,the patient's clinical total effective rate was 67.50%,the control group (P<0.05). Conclusion In patients with chronic bronchitis with the method of combining traditional Chinese and western medicine treatment,help the patient's physical and mental rehabilitation,is worth to be widely applied in clinical.%目的:分析对慢性支气管炎患者采用呼吸内科规范治疗的临床价值及安全性。方法随机选择80例慢性支气管炎患者作为研究对象,对照组40例患者采用常规方案进行治疗;实验组40例患者采用呼吸内科规范治疗方案进行治疗。结果实验组患者的临床总有效率为95.00%,对照组患者的临床总有效率为67.50%,(P<0.05)差异有统计学意义。结论对慢性支气管炎患者采用中西医结合的方式进行治疗,有助于患者的身心康复,值得临床中广泛推广应用。

  12. 慢性支气管炎的临床疗效对比观察%Comparative Observation on Clinical Effects of Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    牛丹

    2015-01-01

    目的:对比分析核酪注射液治疗慢性支气管炎的临床疗效。方法选择慢性支气管炎296例,随机分组,核酪注射液组和常规治疗组,以咳嗽、咯痰为观察指标,疗前、疗后4天、用药结束后2天为时间点。结果两组比较,祛痰总积分及咳嗽有效率,核酪注射液组优于常规治疗组,P<0.05,差异具有统计学意义。结论治疗慢性支气管炎,辅助应用核酪注射液具有一定临床价值。%Objective Contrastive analysis the clinical effects on casein injection in treatmentof chronic bronchitis. Methods Selected 296 cases with chronic bronchitis, randomly divide into nuclear casein injection group and general therapy group. cough and expectoration were selected as outcome measures. The observation time point were set as the time before the treatment, the four days after the treatment and the second day after the end of treatment. Results Compared with two groups of cough and expectorant effect rate, the nuclear casein injection group was better than the conventional therapy group, P<0.05, had difference statistically signiifcance. Conclusion Casein injection has a certain value in treatment of chronic bronchitis.

  13. 老年慢性支气管炎合并肺气肿临床诊治%Clinical Diagnosis and Treatment of Geriatric Chronic Bronchitis With Emphysema

    Institute of Scientific and Technical Information of China (English)

    荣丽红

    2015-01-01

    目的:探讨老年慢性支气管炎合并肺气肿的临床治疗效果。方法随机将120例慢性支气管炎肺气肿患者分为两组,每组60例。观察组采用中西医联合治疗,对照组采用西医治疗。结果观察组总有效率显著优于对照组。治疗后观察组呼气量、残气量及最大通气量好转情况均明显优于对照组(P<0.05)。结论采用中西医治疗慢性支气管炎肺气肿疾病,临床疗效显著。%Objective To investigate the clinical therapeutic effects of senile chronic bronchitis with emphysema. Methods 120 patients with chronic bronchitis, emphysema were randomly divided into two groups, 40 cases in each group. Observation group with combined Chinese and western medicine treatment, the control group with western medicine treatment. Results The total effective rate was significantly superior to control group. Volume in observation group after treatment, the residual capacity improvements and the chase volume were signiifcantly better than that of control group (P<0.05). Conclusion The therapy of Chinese and western medicine, chronic bronchitis, emphysema disease clinical curative effect is distinct.

  14. 老年慢性支气管炎合并结核病的临床分析%Clinical Analysis of Senile Chronic Bronchitis Complicated With Tuberculosis

    Institute of Scientific and Technical Information of China (English)

    林海

    2015-01-01

    Objective To study the clinical characteristics of senile chronic bronchitis complicated with tuberculosis, and provide reference for the treatment of this disease.MethodsFrom 2012 to 2013 in our hospital, 52 cases of senile chronic bronchitis complicated with tuberculosis patients were chosen for analysis and discussion, the clinical symptoms of patients were observed.Results 72.6% of patients experienced misdiagnosis and missed diagnosis, 39 patients were because of its similar symptoms and chronic bronchitis, conforms to the diagnosis standard, which lead to missed diagnosis, misdiagnosis in 6 cases, 4 cases were diagnosis as pneumonia, 2 cases diagnosed as pulmonary abscess.Conclusion The clinical diagnosis of senile chronic bronchitis complicated with tuberculosis should be cautious, provide the basis for the treatment of early diagnosis, to avoid misdiagnosis and missed diagnosis, ensure patients’ health and safety.%目的:研究分析老年慢性支气管炎合并结核病的临床特征,为该病的治疗提供参考。方法对2012~2013年我院的52例老年慢性支气管炎合并结核病患者进行探讨分析,对患者的临床症状进行观察。结果全部患者中有72.6%的患者出现了误诊和漏诊,有39例患者是因为其症状与慢性支气管炎相似,符合其诊断标准导致漏诊;6例误诊患者,4例被作为肺炎进行诊断,2例作为肺脓肿诊断。结论老年慢性支气管炎合并结核病的临床诊断应谨慎,尽早诊断提供针对性的治疗,避免误诊和漏诊,保障患者的健康和安全。

  15. 自拟咳嗽方治疗急慢性支气管炎200例疗效观察%The effect of self cough decoction in the treatment of acute,chronic bronchitis in 200 cases

    Institute of Scientific and Technical Information of China (English)

    鲜晓燕; 张鲁燕

    2014-01-01

    Objective:To observe the curative effect of self cough decoction add and subtract in the treatment of acute and chronic bronchitis.Methods:200 cases of patients with acute and chronic bronchitis were used self cough decoction add and subtract treatment.Results:The total effective rate was 100%.Conclusion:The curative effect of self cough decoction in the treatment of acute and chronic bronchitis is satisfactory.%目的:观察自拟止咳方加减治疗急慢性支气管炎的疗效。方法:对200例急慢性支气管炎患者采用自拟止咳方加减治疗。结果:总有效率100%。结论:自拟止咳方治疗急慢性支气管炎疗效满意。

  16. Systematic review with meta-analysis of the epidemiological evidence relating smoking to COPD, chronic bronchitis and emphysema

    Directory of Open Access Journals (Sweden)

    Thornton Alison J

    2011-06-01

    Full Text Available Abstract Background Smoking is a known cause of the outcomes COPD, chronic bronchitis (CB and emphysema, but no previous systematic review exists. We summarize evidence for various smoking indices. Methods Based on MEDLINE searches and other sources we obtained papers published to 2006 describing epidemiological studies relating incidence or prevalence of these outcomes to smoking. Studies in children or adolescents, or in populations at high respiratory disease risk or with co-existing diseases were excluded. Study-specific data were extracted on design, exposures and outcomes considered, and confounder adjustment. For each outcome RRs/ORs and 95% CIs were extracted for ever, current and ex smoking and various dose response indices, and meta-analyses and meta-regressions conducted to determine how relationships were modified by various study and RR characteristics. Results Of 218 studies identified, 133 provide data for COPD, 101 for CB and 28 for emphysema. RR estimates are markedly heterogeneous. Based on random-effects meta-analyses of most-adjusted RR/ORs, estimates are elevated for ever smoking (COPD 2.89, CI 2.63-3.17, n = 129 RRs; CB 2.69, 2.50-2.90, n = 114; emphysema 4.51, 3.38-6.02, n = 28, current smoking (COPD 3.51, 3.08-3.99; CB 3.41, 3.13-3.72; emphysema 4.87, 2.83-8.41 and ex smoking (COPD 2.35, 2.11-2.63; CB 1.63, 1.50-1.78; emphysema 3.52, 2.51-4.94. For COPD, RRs are higher for males, for studies conducted in North America, for cigarette smoking rather than any product smoking, and where the unexposed base is never smoking any product, and are markedly lower when asthma is included in the COPD definition. Variations by sex, continent, smoking product and unexposed group are in the same direction for CB, but less clearly demonstrated. For all outcomes RRs are higher when based on mortality, and for COPD are markedly lower when based on lung function. For all outcomes, risk increases with amount smoked and pack-years. Limited

  17. 中医外治疗法防治慢性支气管炎研究进展%Progress of Research on the Prevention and Treatment of Chronic Bronchitis by External Application of Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    陆广利; 陈仪新; 邓家刚

    2015-01-01

    近年来,中医外治疗法防治慢性支气管炎的研究取得了新进展,本文就此做一综述,为临床防治慢性支气管炎提供参考。%In recent years,there was new progress on the prevention and treatment of chronic bronchitis by external use of Chinese medicine.This article made a review to provide a reference for the clinic prevention and treatment of chronic bronchitis.

  18. [A method for studying social security records in epidemiology. Use in a study on the prognosis of chronic bronchitis (author's transl)].

    Science.gov (United States)

    Kauffmann, F; Bahi, J; Brille, D

    1976-01-01

    A method is presented to study, in an epidemiological research, the social security records. This study is based upon records of workers affiliated to the french social security general system. To obtain data which may be compared, it was necessary to take the legislation as a basis; this legislation gives the data which must be in the records. A study of laws and rules has been done to find out these data in the medical record and in the administrative one. A questionnaire is presented. This basic questionnaire should be modified according to the precise objectives of each study and to the characteristics of the population sample. To illustrate this method, some results of a study of chronic bronchitis risk factors are presented in the second part. These results concern 950 men, born in France, aged 30 to 59 in 1960 an still alive in 1972. The study of the long reductions of the ability to work, happened from 1960 to 1971, confirm the disabling character of the group "chronic bronchitis, asthma, emphysema, respiratory insufficiency" which follows immediately cardiovascular and rheumatic diseases. The total number of beneficiaries of the social security is already very important and the whole population will be soon concerned. The use of the social security records as data source could give very interesting informations about morbidity. So, it is possible to study representative samples of the general population or of some particular groups, which has up to now, been done only in a slight extent.

  19. Chronic obstructive pulmonary disease - adults - discharge

    Science.gov (United States)

    COPD - adults - discharge; Chronic obstructive airways disease - adults - discharge; Chronic obstructive lung disease - adults - discharge; Chronic bronchitis - adults - discharge; Emphysema - adults - discharge; Bronchitis - ...

  20. Chronic bronchitis and current smoking are associated with more goblet cells in moderate to severe COPD and smokers without airflow obstruction.

    Directory of Open Access Journals (Sweden)

    Victor Kim

    Full Text Available Goblet cell hyperplasia is a classic but variable pathologic finding in COPD. Current literature shows that smoking is a risk factor for chronic bronchitis but the relationship of these clinical features to the presence and magnitude of large airway goblet cell hyperplasia has not been well described. We hypothesized that current smokers and chronic bronchitics would have more goblet cells than nonsmokers or those without chronic bronchitis (CB, independent of airflow obstruction.We recruited 15 subjects with moderate to severe COPD, 12 healthy smokers, and 11 healthy nonsmokers. Six endobronchial mucosal biopsies per subject were obtained by bronchoscopy and stained with periodic acid Schiff-Alcian Blue. Goblet cell density (GCD was quantified as goblet cell number per millimeter of basement membrane. Mucin volume density (MVD was quantified as volume of mucin per unit area of basement membrane.Healthy smokers had a greater GCD and MVD than nonsmokers and COPD subjects. COPD subjects had a greater GCD than nonsmokers. When current smokers (healthy smokers and COPD current smokers, n = 19 were compared with all nonsmokers (nonsmoking controls and COPD ex-smokers, n = 19, current smokers had a greater GCD and MVD. When those with CB (n = 12 were compared to those without CB (n = 26, the CB group had greater GCD. This finding was also seen in those with CB in the COPD group alone. In multivariate analysis, current smoking and CB were significant predictors of GCD using demographics, lung function, and smoking pack years as covariates. All other covariates were not significant predictors of GCD or MVD.Current smoking is associated with a more goblet cell hyperplasia and number, and CB is associated with more goblet cells, independent of the presence of airflow obstruction. This provides clinical and pathologic correlation for smokers with and without COPD.

  1. 慢性支气管炎的护理干预效果观察%Effect of nursing intervention on chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    贺国庆

    2014-01-01

    目的:探讨慢性支气管炎患者的护理效果。方法我院从2011年3月-2013年1月共收治慢性支气管炎患者100例,给予临床观察、心理护理、用药护理、生活护理、健康指导等,对其临床护理资料进行回顾性分析。结果在本组的100例慢性支气管炎患者中,经过治疗与护理之后,显效的患者86例,所占的比例是86%,有效的患者12例,所占的比例是12%,无效的患者2例,所占的比例是2%,总有效率是98%。在本组的患者中,住院时间最短的是7 d,最长的是23 d,平均住院时间是(13.8±4.8)d。本组患者均没有严重的并发症。结论对于慢性支气管炎患者,通过给予全方面的科学护理,有利于患者的病情早日康复,降低并发症的发生率,提高患者的生存质量。%Objective To investigate the nursing effect of patients with chronic bronchitis. Methods In our hospital from 2011 March to 2013 January were treated 100 patients with chronic bronchitis, given clinical observation, mental nursing, medication nursing, nursing, health guidance, the clinical nursing data were retrospectively analyzed. Results In 100 cases of chronic bron-chitis patients in this group, after treatment and nursing care of 86 cases of patients, effective, proportion is 86%, 12 cases were ef-fective in patients, the proportion was 12%, 2 cases of invalid patients, the proportion was 2%, the total efficiency is 98%. In this group of patients, hospitalized in the shortest period of time is 7 days, the longest is 23 days, average hospitalization time was (13.8 ± 4.8) days. The patients had no serious complications. Conclusion For the patients of chronic bronchitis, by giving the scientific com-prehensive nursing, conducive to patient recovery, reduce the incidence of complications, improve the quality of life of patients.

  2. How Can Bronchitis Be Prevented?

    Science.gov (United States)

    ... Topics » Bronchitis » How Can Bronchitis Be Prevented? Explore Bronchitis What Is... Other Names Causes Who Is at Risk Signs & Symptoms Diagnosis Treatments Prevention Living With Clinical Trials Links Related Topics ...

  3. 慢性支气管炎患者的临床治疗体会%The Clinical Experience in Treatment of Patients With Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    王永新

    2015-01-01

    Objective The clinical treatment approach and its efficacy in treatment of chronic bronchitis patients are to be investigated.Methods Choose 79 chronic bronchitis patients who are treated in hospital from July 2013 to August 2014 and separate them into study group and control group at random, 42 patients in study group are given comprehensive treatment,while 37 patients in control group are given conventional treatment; and then observe and compare treatment efficacy of two groups.Results The treatment efficacy in study group is up to 95.24%,while treatment efficacy in control group is 83.78%; there is a treatment efficacy differential between the two groups,and such a differential has statistic value(P<0.05).Conclusion The comprehensive treatment is conducive to improving patients’ symptoms,reducing complication incidence and increasing treatment efficacy; thus, it is quite worthwhile to be promoted.%目的:探究慢性支气管炎患者的治疗方法和效果。方法选取2013年7月~2014年8月收治的79例慢性支气管炎患者进行治疗,随机分组,实验组42例给予综合治疗,对照组37例患者采取常规治疗,对比患者的治疗效果。结果实验组患者治疗有效率为95.24%,对照组患者治疗有效率为83.78%。两组患者的治疗效果差异显著,具有统计学意义(P<0.05)。结论慢性支气管炎患者采用综合诊治,可促使身体症状得到明显改善,减少并发症,提高治疗效果。

  4. 中医辨证治疗慢性支气管炎肺气肿临床分析%Clinical analysis on TCM treatment in chronic bronchitis emphysema

    Institute of Scientific and Technical Information of China (English)

    蔡达

    2012-01-01

      Objective: To investigate the effect of TCM treatment by differentiation of symptoms and signs in chronic bronchitis emphysema. Methods: 76 patients of chronic bronchitis emphysema were treated with TCM treatment by differentiation of symptoms and signs. Results: After treatment, the outcome of 50 patients turned to be excellent, good in 20 patients and poor in another 6 patients. The effective rate was 92.11%. Conclusion: TCM treatment had exact effect on chronic bronchitis emphysema, worth a wide application.%  目的:探讨中医辨证治疗慢性支气管炎肺气肿效果.方法:对本院收治76例慢性支气管炎肺气肿患者进行中医辨证治疗.结果:通过中医辨证治疗,本组患者疗效优50例,疗效良20例,疗效差6例,疗效优良率92.11%.结论:中医辨证治疗慢性支气管炎肺气肿具有确切的临床疗效,值得推广.

  5. 厚朴麻黄汤治疗慢性支气管炎肺气肿临床观察%Clinical Observation on Treatment of Chronic Bronchitis and Emphysema Houpu Mahuang Decoction

    Institute of Scientific and Technical Information of China (English)

    朱海玲; 郭伟明; 刘艳伟; 石美

    2016-01-01

    目的:探讨慢性支气管炎肺气肿采用中药厚朴麻黄汤治疗的效果。方法选取慢性支气管炎肺气肿患者50例,实验组采用厚朴麻黄汤治疗;对照组采用常规西医治疗。结果实验组有效率为84%,对照组为64%,差异具有统计学意义(P<0.05)。结论针对慢性支气管炎肺气肿疾病采用厚朴麻黄汤药物治疗更加有效。%Objective To investigate the effects of chronic bronchitis and emphysema using traditional Chinese medicine magnolia ephedra decoction treatment effect.Methods A total of 50 cases of patients with chronic bronchitis and emphysema, the experimental group the Houpu Mahuang decoction in the treatment, the control group was treated with routine western medicine therapy.Results The effective rate of the experimental group was 84%, the control group was 64%, and the difference was statistically significant (P<0.05). Conclusion For chronic bronchitis emphysema by Magnolia Mahuang Decoction treatment more effective drugs.

  6. Three sons to support pro-Tang Erchen treatment of chronic bronchitis%三子养亲汤合二陈汤治疗慢性支气管炎

    Institute of Scientific and Technical Information of China (English)

    侯维峰; 吕巧珍

    2013-01-01

    Objective To explore the clinical effect of three sons to support parents two Tang Decoction Treatment of chronic bronchitis. Methods the 32 cases of chronic bronchitis patients with three sons to support parents Decoction decoction treatment two. Results the clinical total effective rate reached 96%. Conclusion the curative effect of chronic bronchitis treated by this method is accurate, it is worthy of clinical application.%目的探讨三子养亲汤合二陈汤治疗慢性支气管炎的临床疗效。方法本文慢性支气管炎患者32例应用三子养亲汤合二陈汤进行治疗。结果临床总有效率达到96%。结论慢性支气管炎应用此方法治疗疗效确切,值得临床推广应用。

  7. 厚朴麻黄汤治疗慢性支气管炎的临床对比研究%A clinical comparative study of Houpu Mahuang Decoction in the treatment of chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    孟召莲

    2015-01-01

    目的:探讨厚朴麻黄汤治疗慢性支气管炎的临床研究,为以后的临床诊断治疗提供一定参考。方法本次研究通过收集本院2012年12月至2014年12月期间收治的80例慢性支气管炎病人,随机分为治疗组和对照组,每组各40例。对照组病人服用复方支气管炎片治疗;治疗组病人服用厚朴麻黄汤进行治疗。结果治疗组总有效率为85%,对照组总有效率为75%,差异有显著性意义(P<0.05)。结论厚朴麻黄汤对慢性支气管炎疗效显著,值得以后在临床工作中推广应用。%ABSTRACT:Objective:To investigate the treatment of chronic bronchitis Mangnolia ephedrasoup clinical studies to provide a reference for future clinical diagnosis and treatment. Methods:This study was collected by our hospital from December 2012 to December 2014 period 80 cases of chronic bronchitis who were randomly divided into treatment group and control group 40 cases. Patients in the control group received compound in the treatment of bronchitis;patient treatment group took Mangnolia ephedra soup treatment. Results:The total effective rate was 85% in the control group, the total effective rate of 75%, the difference was signiifcant (P<0.05). Conclusion:Mangnolia ephedra soup signiifcant effect on chronic bronchitis, worth after application in clinical work.

  8. 环磷酰胺成功治疗慢性支气管炎并系统性红斑狼疮一例分析%Role of Cyclophosphamide in the Successful Treatment of Chronic Bronchitis Complicated With Systemic Lupus Erythematosus

    Institute of Scientific and Technical Information of China (English)

    王松; 胡克

    2016-01-01

    慢性支气管炎是由于感染或非感染因素引起的气管、支气管黏膜及其周围组织慢性非特异性炎症。环磷酰胺属细胞毒性药物,可能通过抑制髓源抑制性细胞生成而减轻慢性支气管炎症状。本文报道的1例慢性支气管炎并系统性红斑狼疮患者使用环磷酰胺治疗后慢性支气管炎症状消失,提示细胞毒性药物可能对慢性支气管炎具有一定的治疗作用。%Chronic bronchitis belongs to chronic nonspecific inflammation,mainly involves trachea mucosa,bronchial mucosa and their surrounding tissues,its nosogenesis includes infectious factors and noninfectious factors. Cyclophosphamide is one kind of cytotoxic agents,may relieve the symptoms of chronic bronchitis by inhibiting the cytopoiesis of myeloid - derived suppressor cells. This paper reported a chronic bronchitis patient complicated with systemic lupus erythematosus whose symptoms of chronic bronchitis successfully disappeared after treatment of cyclophosphamide,it reminds that cytotoxic agents may have some therapeutic effects on chronic bronchitis.

  9. Gemifloxacin for the treatment of community-acquired pneumonia and acute exacerbation of chronic bronchitis: a meta-analysis of randomized controlled trials

    Institute of Scientific and Technical Information of China (English)

    ZHANG Lei; WANG Rui; Falagas E. Matthew; CHEN Liang-an; LIU You-ning

    2012-01-01

    Background Gemifloxacin is a fluoroquinolone antibiotic with broad spectrum of antibacterial activity.The aim of the study was to evaluate the comparative effectiveness and safety of gemifloxacin for the treatment of patients with community-acquired pneumonia (CAP) or acute exacerbation of chronic bronchitis (AECB).Methods We performed a meta-analysis of randomized controlled trials (RCTs) comparing gemifloxacin with other approved antibiotics.The PubMed,EMBASE,Chinese Biomedical Literature Database and the Cochrane Central Register of Controlled Trials were searched,with no language restrictions.Results Ten RCTs,comparing gemifloxacin with other quinolones (in 5 RCTs) and β-lactams and/or macrolides (in 5 RCTs),involving 3940 patients,were included in this meta-analysis.Overall,the treatment success was higher for gemifloxacin when compared with other antibiotics (odds ratio 1.39,95% confidence interval 1.15-1.68 in intention-to-treat patients,and 1.33,1.02-1.73 in clinically evaluable patients).There was no significant difference between the compared antibiotics regarding microbiological success (1.19,0.84-1.68) or all-cause mortality (0.82,0.41-1.63).The total drug related adverse events were similar for gemifloxacin when compared with other quinolones (0.89,0.56-1.41),while lower when compared with β-lactams and/or macrolides (0.71,0.57-0.89).In subgroup analyses,administration of gemifloxacin was associated with fewer cases of diarrhoea and more rashes compared with other antibiotics (0.66,0.48-0.91,and 2.36,1.18-4.74,respectively).Conclusions The available evidence suggests that gemifloxacin 320 mg oral daily is equivalent or superior to other approved antibiotics in effectiveness and safety for CAP and AECB.The development of rash represents potential limitation of gemifloxacin.

  10. Clinical intervention observation on of non-pharmaceutical therapy for chronic bronchitis%非药物疗法对慢性支气管炎的临床干预观察

    Institute of Scientific and Technical Information of China (English)

    黎旻

    2014-01-01

    Objective To discuss the clinical intervention effect of non-pharmaceutical therapy for chronic bronchitis. Methods 72 cases with chronic bronchitis treated in our hospital were selected and divided into the two groups accord-ing to treatment methods,the treatment group (treated with acupuncture therapy) and the control group (treated with ba-sic therapy),each group for 36 cases.The clinical curative effect of the two groups. Results The total effective rate of the treatment group (97.22%) was higher than that in the control group (75.00%) (P<0.05). Conclusion Non-pharmaceuti-cal therapy for chronic bronchitis not only has evident effect in clinical practice,but also can improve the clinical symptoms and life quality of patients.%目的:探讨非药物疗法对慢性支气管炎的临床干预效果。方法选取本院收治的慢性支气管炎患者72例,按治疗方法将其分为治疗组(采用针灸方法治疗)和对照组(采用基础治疗方法治疗),各36例。对比两组的临床疗效。结果治疗组的总有效率为97.22%,高于对照组的75.00%(P<0.05)。结论非药物疗法在临床上治疗慢性支气管炎具有良好的作用,能改善患者的临床症状及生活质量。

  11. 莫西沙星联合盐酸氨溴索治疗慢性支气管炎的效果研究%Effect on Moxifloxacin Combined With Ambroxol Hydrochloride in Treatment of Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    高俊耀

    2016-01-01

    目的:研究莫西沙星联合盐酸氨溴索对慢性支气管炎的治疗效果。方法研究2015年1~10月慢性支气管炎患者66例,依照数字法分组。采用常规疗法者33例,进入对照组;采用莫西沙星联合盐酸氨溴索者33例,进入实验组。组间比较。结果两组中实验组的咳痰、咳嗽及喘息消失时间更短,住院日更短,治疗有效率更高,差异有统计学意义(P<0.05)。结论莫西沙星联合盐酸氨溴索治疗慢性支气管炎效果较佳。%Objective Moxifloxacin combined with ambroxol hydrochloride effect in treatment of chronic bronchitis is to be studied. Methods Chose 66 patients of chronic bronchitis who were treated in hospital from January 2015 to October 2015 and separated them into two groups according to digits. 33 patients in control group were given conventional treatment,while another 33 patients in study group were given moxifloxacin combined with ambroxol hydrochloride treatment and then compared treatment effects between two groups. Results Patients’symptoms disappeared time of sputum,cough and wheezing is shorter and treatment efficacy was higher in study group compared to counterparts in control group,there was a differential between two groups and such a differential has statistic value(P<0.05). Conclusion Moxifloxacin combined with ambroxol Hydrochloride is quite effective in treatment of chronic bronchitis.

  12. The treatment of senile pulmonary tuberculosis, chronic bronchitis emphysema and comprehensive analysis%老年性肺结核合并慢支肺气肿综合性治疗的临床分析

    Institute of Scientific and Technical Information of China (English)

    王利萍

    2014-01-01

    目的:对老年性肺结核合并慢支肺气肿的临床治疗方法进行分析研究。方法选取本中心结核病门诊接受肺结核合并慢支肺气肿治疗的患者120名,其中60仅抗结核治疗,作为对照组。另外60名患者在抗结核的基础上给予抗感染等综合性治疗肺部基础疾病,作为观察组,比较两组治疗效果。结果观察组疗效优于对照组(P<0.05)。结论对于肺结核合并慢支肺气肿的患者采取综合性治疗效果优于单纯的抗结核治疗,病灶吸收较快,治愈率高,复发率低。%objective to the clinical therapy of senile pulmonary tuberculosis chronic bronchitis emphysema method are studied. Method to select the center tuberculosis outpatient tuberculosis and chronic bronchitis emphysema treated patients, 120, 60 of them anti-tuberculosis treatment, just as the control group. Another 60 patients on the basis of anti-tuberculosis give comprehensive basic treatment of lung diseases such as anti-infection, as observation group, compared two groups of therapeutic effect. Results observation group curative effect is better than that of control group (P < 0.05). Conclusion for patients with tuberculosis and chronic bronchitis emphysema comprehensive treatment effect is better than that of pure anti-tuberculosis treatment, lesion absorption faster, high cure rate, recurrence rate is low.

  13. 老年慢支合并肺气肿应用中医辨证治疗的效果分析%Effect analysis of TCM syndrome differentiation in the treatment of elderly chronic bronchitis combined with emphysema

    Institute of Scientific and Technical Information of China (English)

    阿依先木古力·依明

    2016-01-01

    目的:分析中医辨证治疗老年慢支合并肺气肿的效果。方法:收治老年慢支合并肺气肿患者60例,随机分为对照组和治疗组各30例。对两组患者均给予常规治疗,治疗组给予中医辨证治疗,比较两组患者治疗效果。结果:治疗组治疗效果显著优于对照组(P<0.05)。结论:中医辨证治疗老年慢支合并肺气肿患者有利于患者症状的改善,可提高治疗效果,疗效确切。%Objective:To analyze the effect of TCM syndrome differentiation in the treatment of elderly chronic bronchitis combined with emphysema.Methods:60 patients with elderly chronic bronchitis combined with emphysema were selected.They were randomly divided into the control group and the treatment group with 30 cases in each.The patients in two groups were given conventional treatment.The treatment group was given TCM syndrome differentiation treatment.The treatment effects of two groups were compared.Results:The treatment effect of the treatment group was significantly better than that of the control group(P<0.05). Conclusion:TCM syndrome differentiation in the treatment of elderly chronic bronchitis combined with emphysema is beneficial to improve the symptoms of patients and improve the treatment effect of patients.The curative effect is accurate.

  14. 热毒宁治疗慢性支气管炎急性发作期的临床价值研究%Clinical value of Re Du Ning in the treatment of acute exacerbation of chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    王企万

    2016-01-01

    Objective:To explore the clinical value of Re Du Ning in the treatment of acute exacerbation of chronic bronchitis. Methods:100 patients with acute exacerbations of chronic bronchitis were selected.They were randomly divided into the control group and the treatment group.The control group was given conventional treatment.The treatment group added Re Du Ning on the basis of the control group.We compared the therapeutic effect of two groups.Results:In the treatment group,the total effective rate and treatment effect were significantly better than those in the control group(P<0.05).Conclusion:The clinical value of Re Du Ning in the treatment of acute exacerbation of chronic bronchitis was significant.%目的:探讨热毒宁治疗慢性支气管炎急性发作期的临床价值。方法:收治慢性支气管炎急性发作期患者100例,随机分为对照组和治疗组,对照组采用常规治疗,治疗组在对照组基础上加用热毒宁治疗,比较两组治疗效果。结果:治疗组总有效率和治疗效果均明显优于对照组(P<0.05)。结论:热毒宁治疗慢性支气管炎急性发作期的临床效果显著。

  15. Experience of the treatment of chronic bronchitis in department of respiratory medicine specification%慢性支气管炎呼吸内科规范治疗体会

    Institute of Scientific and Technical Information of China (English)

    舒国华

    2016-01-01

    Objective:To analyse the effect of chronic bronchitis patients receiving standard treatment in department of respiratory internal medicine,and summarize the experience of treatment.Methods:80 patients with chronic bronchitis were selected.They were divided into the observation group and the control group,40 cases in each.The therapeutic effect was compared. Results:The total effective rate of observation group was higher than that of control group(P<0.05);the treatment time and the incidence of adverse reaction of the observation group were lower than those of the control group(P<0.05).Conclusion:Standard treatment is conducive to improve the overall curative effect of the patients with chronic bronchitis,and it has the low incidence of adverse reactions.%目的:分析慢性支气管炎患者在呼吸内科接受规范治疗的效果,并总结有效的治疗经验。方法:收治慢性支气管炎患者80例,分为观察组和对照组,各40例,对比治疗效果。结果:观察组的治疗总有效率高于对照组(P<0.05);观察组的治疗时间和不良反应发生率低于对照组(P<0.05)。结论:呼吸内科规范治疗有利于改善慢性支气管炎患者的整体疗效,且不良反应发生率低。

  16. 慢性支气管炎、肺气肿58例患者的临床治疗与观察%Clinical Observation and Treatment of Chronic Bronchitis and Emphysema in 58 Cases

    Institute of Scientific and Technical Information of China (English)

    蔡娜; 盖龙

    2016-01-01

    目的:探讨慢支、肺气肿的治疗方法,以及取得的疗效。方法对我院收治的58例慢支、肺气肿患者进行研究,分析其临床资料。结果所有患者给予积极治疗后,取得了显著的成效。总有效率为96.6%。1例死亡。结论慢支、肺气肿病因复杂,治疗时间长,反复发作,容易诱发其他并发症,导致病情恶化。因此,给予早期治疗与干预,能够防止病情恶化,从而提高治疗效率。%Objective To investigate the treatment of chronic bronchitis and emphysema,and the curative effect.Methods 58 cases of patients with chronic bronchitis and emphysema in our hospital,the clinical data was analyzed. ResultsAl patients were given active treatment,and achieved remarkable results. The total effective rate was 96.6%. 1 cases of death.Conclusion Chronic bronchitis and emphysema had complicated etiology,treatment for a long time,recurrent,easy to cause other complications,resulting in disease progression. Therefore,early treatment and intervention can prevent the disease from deteriorating,so as to improve the treatment efficiency.

  17. Observation Effect of Traditional Chinese Medicine Syndrome Differentiation in Treatment of Chronic Bronchitis Combine With Emphysema%慢性支气管炎肺气肿中医辨证治疗效果观察

    Institute of Scientific and Technical Information of China (English)

    刘爱琴

    2015-01-01

    目的:分析慢性支气管炎肺气肿中医辨证治疗效果。方法选取本院收治的慢性支气管炎肺气肿患者60例为研究对象,将其随机分为对照组与观察组,对照组采用常规西医治疗,观察组给予中药厚朴麻黄汤辩证加减,比较两组患者临床疗效和不良反应发生情况。结果对比两组患者临床疗效和不良反应发生情况,P<0.05,差异具有统计学意义。结论慢性支气管炎肺气肿患者采取中医辨证治疗,疗效显著,有效降低不良反应发生率。%Objective Aanalysis effect of traditional Chinese medicine syndrome differentiation in treatment of chronic bronchitis combine with emphysema.Methods Selected 60 patients with chronic bronchitis in our hospital were analyzed, emphysema as the research object, were randomly divided into the control group and the observation group, the control group with conventional western medicine treatment, the observation of ephedra decoction group was given traditional Chinese medicine dialectical add and subtract, compared two groups of patients with clinical efifcacy and adverse reactions occur.Results Compared two groups of patients and the clinical curative effect and adverse reaction,P<0.05, had difference statistically signiifcance.Conclusion Chronic bronchitis, emphysema patients treated with traditional Chinese medicine syndrome differentiation, curative effect is distinct, effectively reduce the incidence of adverse reactions.

  18. 老年慢性支气管炎的成因与社区干预研究%Research on the causes and the community intervention methods of senile chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    杨丹华

    2015-01-01

    Objective:To analyze the causes of senile chronic bronchitis,and research the countermeasure of community intervention.Methods:50 patients with chronic bronchitis that more than 65 years old were selected.They were randomly divided into the observation group and the control group with 25 cases in each.Patients in the control group were received routine treatment,while the observation group were given intervention measures for several community based on the conventional drug treatment.Then we compared the efficacy of intervention between the two groups.Results:After the community intervention treatment,the total efficiency of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:The etiology of chronic bronchitis was complicated.Community intervention can significantly improve the curative effect of senile chronic bronchitis,and also improve the prognosis of patients.%目的:分析老年慢性支气管炎的成因,研究社区干预对策。方法:收治65岁以上慢性支气管炎患者50例,随机分为观察组与对照组,各25例。对照组给予常规药物治疗,观察组在常规药物治疗的基础上给予若干社区干预措施。比较两组患者干预后的疗效情况。结果:经社区干预后,观察组治疗总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论:慢性支气管炎的病因复杂,社区干预能明显提高老年慢性支气管炎的疗效,改善患者预后。

  19. 中医整体辨证护理干预慢性支气管炎效果观察%TCM Holistic Nursing Intervention for Chronic Bronchitis Syndrome Efficacy

    Institute of Scientific and Technical Information of China (English)

    朱东华; 胡志伟; 朱金星; 范春玲

    2015-01-01

    Objective Explore the application of traditional Chinese medicine overal dialectical nursing intervention curative ef ect and mechanism of chronic bronchitis. Methods By treating winter disease in summer,physiotherapy,acupuncture,health lifestyle guide TCM holistic nursing measures. Results Enhance the patient's physique,improve respiratory function,reducing the need for hospitalization. Conclusion Application of traditional Chinese medicine nursing skil s intervention chronic bronchitis,improve the body's resistance to disease and avoid side ef ects of antibiotics,and promote early recovery of patients.%目的:探讨应用中医整体辨证护理干预慢性支气管炎的疗效和机制。方法采用冬病夏治、理疗、针灸、健康生活方式指导等中医整体护理措施。结果增强了患者的体质,改善了呼吸功能,住院的需求也减少了。结论中医护理技术干预慢性支气管炎中的应用,提高机体的抗病能力,避免抗生素的副作用,促进患者早日康复。

  20. Greatest International ANtiinfective Trial (GIANT with moxifloxacin in the treatment of acute exacerbation of  chronic bronchitis: subanalysis of Chinese data of a global, multicenter, noninterventional study

    Directory of Open Access Journals (Sweden)

    Yulin Feng

    2010-03-01

    Full Text Available Yulin Feng1, Faguang Jin2, Shuang Mu3, Hong Shen4, Xiaohong Yang5, Yuling Wang6, Zhenshan Wang7, Yingjun Kong8, Zuke Xiao9, Qiming Feng101Respiratory Department, West China Hospital, Sichuan University, China; 2Respiratory Department, Tang Du Hospital, China; 3Respiratory Department, Peking University People’s Hospital, China; 4Emergency Department, The General Hospital of the People’s Liberation Army, China; 5Respiratory Department, Xinjiang People’s Hospital, China; 6Respiratory Department, Shi Jiazhuang First Hospital, China; 7Respiratory Department, The Second Affiliated Hospital of Dalian Medical University, China; 8Respiratory Department, The First Clinical College of Harbin Medical University, China; 9Respiratory Department, The Jiangxi Provincial People’s Hospital, China; 10Emergency Department, Shanghai Sixth People’s Hospital, ChinaBackground and objective: A single infective acute exacerbation of chronic bronchitis (AECB has a sustained effect on health status. Although a number of clinical investigations have demonstrated the efficacy of antibiotics in AECB, increased bacterial resistance has caused concern about the efficacy of currently available antibiotic therapies. This subanalysis of a global noninterventional study aimed to evaluate the impact of AECB on the patient and the community and the effectiveness and safety of a treatment with moxifloxacin (MXF tablets in daily life clinical practice in China.Methods: This prospective, noninterventional, noncontrolled, multicenter observational study, which started in China in April 2004 and ended in February 2007, was part of the global GIANT study. Patients with a diagnosis of mild to severe AECB were treated with MXF tablets 400 mg for a period at the physician’s discretion. The observation period for each patient covered a complete treatment period with MXF. For each patient, the physician documented data at an initial visit (baseline and at least one follow-up visit

  1. Dyspnea and Wheezing after Adenosine Injection in a Patient with Eosinophilic Bronchitis

    Directory of Open Access Journals (Sweden)

    Rodrigo Cartin-Ceba

    2009-01-01

    Full Text Available A 58-year-old nonsmoker female was referred for evaluation of chronic cough of 13 months duration. After an initial work-up, the patient was diagnosed to have chronic cough due to eosinophilic bronchitis. The diagnostic work-up for eosinophilic bronchitis and bronchial biopsy is discussed. Eosinophilic bronchitis is differentiated from asthma. In addition, the patient developed dyspnea, flushing, and wheezing after the administration of adenosine during a cardiac stress test in spite of a negative methacholine challenge. This indirect stimulus of airway hyperresponsiveness suggests the possible involvement of mast cells in eosinophilic bronchitis.

  2. The clinical analysis of 32 cases of chronic bronchitis acute attacking by MRSA infection%MRSA 感染致慢性支气管炎急性发作32例临床分析

    Institute of Scientific and Technical Information of China (English)

    高成兵

    2013-01-01

    Objective: To analyze the clinical effect of treating chronic bronchitis acute at acking by MRSA infection. Methods: Choosed 32 cases of chronic bronchitis acute at acking by MRSA infection from Dec. 2010 to Dec. 2012 to sputum culture experiment and drug sensitive test and treat with vancomycin. Results: The antibiotic susceptible rate of MRSA was 100.0%, the effective rate of study group was 93.8%, adverse rate was 6.2%. Conclusion: There is high rate in primary hospital of chronic bronchitis acute at acking by MRSA infection, but MRSA is sensitive to vancomycin.%目的:分析 MRSA(耐甲氧西林金黄色葡萄球菌)感染所致慢性支气管炎急性发作期相关情况。方法:回顾性分析2010年12月-2012年12月大邑县人民医院呼吸科住院的慢性支气管炎急性发作期的 MRSA 感染患者32例,均行痰培养实验和药敏试验,并均采用万古霉素治疗,统计药敏试验结果和临床治疗情况。结果:MRSA 对万古霉素的敏感率达100.0%;治疗总有效率93.8%,不良反应率为6.2%,临床效果比较显著。结论:基层医院中社区获得性感染致慢性支气管炎的急性发作患者中也存在较高比率的 MRSA 感染;MRSA 对万古霉素敏感,尚未发现有耐药株。

  3. Clinical analysis of elderly patients with chronic bronchitis treated by bushen jianpi qingfei decoction%补肾健脾清肺法治疗老年慢性支气管炎的临床分析

    Institute of Scientific and Technical Information of China (English)

    曾红梅

    2012-01-01

    Objective To explore the clinical efficacy of bushen jianpi qingfei decoction treatment for chronic bronchitis in the elderly patients. Methods 160 patients with chronic bronchitis were selected, they were randomly divided into the observation group and the control group,80 patients each group. The control group was given anti-infective, antitus si ve and expectorant, relieving asthma treatment. The observation group was treated by bushen jianpi qingfei decoction based on the control group. Results The total effective rate of observation group was 97. 5% ,the total effective rate of control group was 87. 5% . The efficacy of observation group was better than that of control group( P < 0. 05 ). Conclusion Bushen jianpi qingfei decoction combined with western medicine treatment for elderly patients with chronic bronchiti is effective.%目的 分析补肾健脾清肺疗法治疗老年慢性支气管炎的临床疗效.方法 近3年来我院就诊的160例老年慢性支气管炎急性发作的患者,随机分为观察组(80例)和对照组(80例),对照组使用西医传统的控制感染、镇咳祛痰、平喘方法,观察组在对照组治疗的基础上予以中药补肾、健脾、清肺治疗.结果 观察组的总有效率为97.5%,对照组的总有效率为87.5%,观察组的疗效明显优于对照组(P<0.05).结论 使用中医中药补肾健脾清肺方法联合西药治疗老年慢性支气管炎疗效显著.

  4. 86 Cases Efficacy Observation of Ambroxol for Chronic Bronchitis%氨溴索治疗慢性支气管炎86例的疗效观察

    Institute of Scientific and Technical Information of China (English)

    陈于荦; 郑曼如; 郑云

    2013-01-01

    Objective:To observe the inhalation of ambroxol the clinical ef icacy of the treatment of chronic bronchitis. Methods:86 cases admit ed to our department with chronic bronchitis were randomly divided into observation group and control groups, each group of 43 cases in the control group of patients treated with conventional methods, the treatment group were observed based on the use of ammonia ambroxol inhalation therapy, 7d after the clinical ef icacy were observed. Results: Compared with the control group (79.07%) compared with the observation group total ef ective rate (95.35%) was significantly higher, the dif erence was statistical y significant (x2=5.108, P<0.05). Conclusion:Ambroxol inhalation method of treatment of chronic bronchitis have bet er clinical ef icacy in clinical application.%目的观察氨溴索雾化吸入治疗慢性支气管炎的临床疗效。方法将我科收治的86例慢性支气管炎的患者随机分为观察组和对照组两组,每组43例,对照组患者使用常规方法进行治疗,观察组在对照组治疗基础上加用氨溴索雾化吸入治疗,7d后观察两组的临床疗效。结果与对照组(79.07%)比较,观察组总有效率(95.35%)明显增高,差异有统计学意义(χ2=5.108,P<0.05)。结论采用氨溴索雾化吸入方法治疗慢性支气管炎有较好的临床疗效,可以在临床上推广应用。

  5. The Application Significance of Attendance Intervention in Treatment of Elderly Patients With Chronic Bronchitis%护理干预在老年慢性支气管炎治疗中的应用研究

    Institute of Scientific and Technical Information of China (English)

    王春玲

    2015-01-01

    Objective To explore the application signiifcance of attendance intervention in treatment of elderly patients with chronic bronchitis. Methods Selected 76 elderly patients with chronic bronchitis who were received in our hospital from August 2013 to August 2014 and separated them into two groups according to different attendance approaches with 38 patients in control group and 38 patients in study group respectively. Patients in control group were given conventional treatment, while patients in study group were given humane care. And then observed and compared treatment efficacy of patients in these two groups. Results Compared to patients in control group, the patients’ quality of life in study group was much better, there was a differential between these two groups, and such a differential had statistic value (P<0.05). Conclusion The idea of humane care exerts greatly positive inlfuence on treatment of elderly patients with chronic bronchitis, which is conducive to improving patients’ quality of life, therefore, it is quite worthwhile to be promoted and applied clinically..%目的:研究护理干预在老年慢性支气管炎治疗中的应用作用。方法搜集2013年8月~2014年8月我院接收的老年慢性支气管炎76例患者,根据不同护理方法分为两组,即对照组38例、研究组38例。对照组护理方法采用常规护理,研究组护理方法采用人性化护理。观察对照组与研究组的护理效果,并比较。结果与对照组相比,研究组生活质量较高,有明显差异,有统计学意义(P<0.05)。结论人性化理念在老年慢性支气管炎护理中渗透作用较大,可有效提升患者生活质量。

  6. Analysis of the effect of ambroxol hydrochloride in the treatment of acute exacerbation of chronic bronchitis%盐酸氨溴索治疗慢性支气管炎急性发作的疗效分析

    Institute of Scientific and Technical Information of China (English)

    丁宁

    2014-01-01

    目的:观察盐酸氨溴索对慢性支气管炎急性发作的临床疗效。方法:选取2012年11月-2014年3月慢性支气管炎急性发作患者60例,随机分为对照组30例和试验组30例。对照组给予吸氧、抗感染、解痉平喘等常规治疗;试验组在常规治疗基础上加用盐酸氨溴索静脉滴注,每次30 mg,每日2次,5 d为1个疗程,共2个疗程,治疗结束后比较两组疗效。结果:试验组的总有效率为96.75%,对照组为76.7%,组间差异有统计学意义(P<0.05)。结论:盐酸氨溴索治疗慢性支气管炎急性发作有较好的临床疗效。%Objective:To observe the clinical effect of ambroxol hydrochloride in the treatment of acute exacerbation of chronic bronchitis. Methods: Sixty cases with acute exacerbation of chronic bronchitis were selected from Nov. 2012 to March 2014 and divided into a control group with 30 patients and an experiment group with 30 patients at the random. The control group was treated with oxygen inhalation, anti-infection, antispasmodic and the conventional therapy. The experiment group was added with ambroxol hydrochloride injection of 30 mg every time, twice a day, 5 days a course for 2 courses based on the conventional therapy. The treatment effects of two groups were compared after the treatment. Results:The total efifcacy was 96.7% in the experiment group, and 76.7% in the control group. The difference of the two groups had the statistical signiifcance (P<0.05). Conclusion:Ambroxol hydrochloride has a good clinical effect in the treatment of acute exacerbation of chronic bronchitis.

  7. 中医辨证治疗慢性支气管炎38例分析%An analysis of treating 38 cases of chronic bronchitis in TCM

    Institute of Scientific and Technical Information of China (English)

    王保峰

    2016-01-01

    目的:分析中医辨证治疗慢性支气管炎的临床效果。方法:选取我院收治的78例慢性支气管患者为例,在本次研究中,对照组(40例)行常规西医治疗,观察组(38例)行中医辨证治疗,然后对比两组的临床效果及临床症状消失时间。结果:观察组的临床效果更为突出(P<0.05)。临床症状消失时间:观察组的呼吸不畅消失时间、喘息消失时间、咳嗽和咳痰消失时间均短语对照组(P<0.05)。结论:针对慢性支气管炎,临床上应优先选择中医辨证治疗,该疗法较之常规西医治疗更为理想,且治疗后,不易产生不良反应。%Objective: To analyze clinical effect of TCM treatment of chronic bronchitis. Methods: 78 cases of chronic bronchitis in our hospital were selected and divided into two groups. The control group (40 cases) received routine western medicine treatment while the observation group (38 cases) was treated with TCM syndrome differentiation treatment. The clinical symptoms disappearance time and the clinical effects of two groups were compared. Results:Clinical effect: the clinical effect of the observation group was more prominent (P< 0.05). Clinical symptoms disappeared time: disappearance time of the shortness of breath, wheezing disappearance time, cough and expectoration disappearance time of the observation group were all shorter than that of the control group (P<0.05). Conclusion: TCM treatment should be preferred in the treatment of chronic bronchitis, it was more ideal than the therapy of conventional western medicine treatment, and after treatment, there was little adverse reactions.

  8. 中药治疗老年慢性支气管炎的临床研究%Observation on Clinical Effect of Chinese Herbs for Treatment of Senile Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    李抒菡

    2015-01-01

    目的:探讨中药治疗老年慢性支气管炎的临床疗效。方法随机选择该院收治的60例老年慢性支气管炎患者,随机分为对照组和观察组,每组各30例,对照组采用一般的抗生素治疗或采用祛痰镇咳药治疗,观察组根据患者不同证型采用不同的中药汤药处方,观察两组的临床治疗疗效。结果观察组的总有效率为93.33%,对照组为80.0%,两组比较差异有统计学意义(P<0.05),观察组的治疗效果优于对照组。结论采用中药治疗老年慢性支气管炎的疗效确切,可明显提高患者的康复率,因此,该法值得临床进一步推广应用。%Objective To observe the clinical effect of Chinese herbs for treatment of senile chronic bronchitis. Methods 60 cases of patients with senile chronic bronchitis were randomly divided into observation group (n=30) and control group (n=30). Patients in the control group were treated with common antibiotics or antitussive and expectorant agent, while those in the observation group were given Chinese herbs based on syndrome differentiation. The clinical effects of the two groups were observed. Results The total effective rate of the observation group was 93.33%, higher than that of the control group 80.0%, and there was statistical-ly significant difference between the two groups (P<0.05). Conclusion Chinese herbs for treatment of senile chronic bronchitis have significant effect, which can obviously improve the recovery rate of patients. Therefore the method is worthy of further clinical application.

  9. 痰热清注射液不同给药途径治疗慢性支气管炎的疗效%Efficacy of Tanreqing Injection in different administration routes in the treatment of chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    邹少雁; 谷小云

    2013-01-01

    Objective To observe the clinical effects of Tangreqing injection in diferent ways on chronic bronchitis. Methods 94 cases with chronic bronchitis were randomly divided into three groups (the control group;the aerosol inhalation group; the intravenous drip group). The control group was given conventional treatment. On the basis of conventional therapy, the aerosol inhalation group received aerosol inhalation of Tanreqing injection, and the intravenous drip group received intravenous drip of Tanreqing injection. To compare the difference among the three groups. Results The total effective rate of the aerosol inhalation group, the intravenous drip group, and the control group was 94.29%, 83.33%, and 75.86%, respectively. There was a significant difference among the three groups (P<0.05). Conclusion The use of aerosol inhalation of Tanreqing injection is safe and effective in the treatment of chronic bronchitis, which is worth spreading.%目的观察痰热清注射液不同给药途径治疗慢性支气管炎的临床疗效。方法将94例患者随机分为三组,各组均予基础治疗,雾化组另予痰热清注射液雾化吸入,注射组给予痰热清注射液静滴,比较三组的治疗效果。结果雾化组、注射组及对照组的总有效率分别为94.29%、83.33%及75.86%。组间比较差异有显著性(P<0.05)。结论痰热清注射液雾化吸入治疗慢性支气管炎疗效满意,安全性好,值得临床推广使用。

  10. Clinical Observation of Souchen Decoction on Treating 80 Cases of Chronic Bronchitis%嗽陈汤治疗慢性支气管炎80例临床观察

    Institute of Scientific and Technical Information of China (English)

    张飚

    2013-01-01

    目的:观察自拟嗽陈汤治疗慢性支气管炎的疗效.方法:选择我院2008年6月至2012年6月门诊治疗的慢性支气管炎患者155例,随机分为对照组75例和治疗组80例.对照组患者给予西医对症治疗,治疗组在对照组的基础上,再口服自拟嗽陈汤.以7天为1个疗程,连续治疗2个疗程,治疗并比较两组患者临床疗效.结果:对照组有效率为73.33%,治疗组有效率为93.75%,两组比较,统计学处理有显著差异(P<0.05).结论:采用自拟嗽陈汤治疗慢性支气管炎有较好疗效.%Objective: Observing the efficacy of self-made Souchen Decoction for treating chronic bronchitis. Methods: Selecting 155 cases of out-patients with chronic bronchitis in our hospital from June 2008 to June 2012. They were randomly divided into control group which was 75 cases and treatment group which was 80 cases. The control group were treated by western medicine , the treatment group were treated by Souchen Decoction on the basis of the control group. Treatment course was 7 days, two courses continued, and clinical efficacy of the two groups were compared. Results: The effective rate was 73. 33% of the control group, the treatment group was 93.75% , there was statistically significant differences (P < 0.05) between the two groups. Conclusion: Self-made Souchen Decoction has better efficacy in the treatment of chronic bronchitis than western medicine.

  11. Clinical Value of Bitter Almond in the Treatment of Chronic Bronchitis%苦杏仁治疗慢性支气管炎的临床价值分析

    Institute of Scientific and Technical Information of China (English)

    徐孝艳

    2016-01-01

    目的:探讨苦杏仁治疗慢性支气管炎的临床效果。方法以2014年1月~2015年1月本院收治的24例慢性支气管炎患者为研究对象,给予其苦杏仁进行治疗,分析临床治疗效果。结果16例患者在服药后5~6 d喘息、咳嗽、咳痰等症状有所缓解;3例患者治疗3个疗程,4例患者治疗4个疗程,6例患者治疗5个疗程,11例患者治疗6个疗程。6个疗程结束后,治疗总有效率为91.7%(22/24),其中,9例基本治愈,10例显效,3例好转,2例无效。结论苦杏仁治疗慢性支气管炎有着较好的临床效果。%Objective To investigate the clinical effect of treating chronic bronchitis with bitter almond.Methods In January 2014 to January 2015 in our hospital,24 cases of chronic bronchitis patients as the research object,to give their bitter almond for treatment,analysis of clinical treatment effect.Results16 cases of patients in the medication after 5~6 d wheezing,cough,sputum and other symptoms eased,3 patients were treated 3 course of treatment,4 patients were treated with four courses,6 patients 5 courses,11 cases of patients 6 courses. After 6 courses of treatment,the total effective rate was 91.7%(22/24),of which,9 cases were basically cured, 10 cases were markedly effective,3 cases improved,2 cases ineffective.Conclusion Bitter almond has good clinical effect in treating chronic bronchitis.

  12. Clinical Analysis of Ambroxol Hydrochloride in the Treatment of Senile Chronic Bronchitis%盐酸氨溴索治疗老年慢性支气管炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    杨瑄琍

    2016-01-01

    Objective To observe the ambroxol treatment of elderly patients with chronic bronchitis clinical results.Methods January 2014-July 2015 in our hospital respiratory medicine hospitalized elderly patients with chronic bronchitis,86 cases were randomly divided into two groups and the control group 43 cases.The control group received conventional treatment,observation group were treated with ambroxol treatment in the control group, based on the clinical efficacy of the two groups of patients.Results The cure rate and the total effective rate was 55.8%and 97.7%respectively in the control group,the cure rate and the total effective rate was 34.9 and 79.1%respectively.Observation group was significantly higher,the difference was significant( <0.05).Conclusion The conventional treatment with ambroxol treatment of elderly patients with chronic bronchitis significant effect.%目的:观察盐酸氨溴索治疗老年慢性支气管炎的临床效果。方法选择2014年1月~2015年7月我院呼吸内科住院的老年慢性支气管炎患者86例,随机分为观察组和对照组各43例。对照组给予常规治疗,观察组在对照组基础上加用盐酸氨溴索治疗,观察两组患者临床疗效。结果观察组痊愈率和总有效率分别为55.8豫和97.7豫,对照组痊愈率和总有效率分别为34.9和79.1豫。观察组明显高于对照组,差异有显著性(<0.05)。结论采用常规治疗配合盐酸氨溴索治疗老年慢性支气管炎疗效显著。

  13. 探讨中医辨证治疗慢性支气管炎肺气肿的临床疗效%Clinical effect investigation on treating chronic bronchitis and emphysema in TCM

    Institute of Scientific and Technical Information of China (English)

    李远新

    2014-01-01

    目的:分析中医辨证方法应用于慢性支气管炎肺气肿患者的临床治疗效果。方法:选取2011年5月~2012年10月我院所收治的慢性支气管炎肺气肿患80例,随机分成两组,每组40例。对照组给予常规的西医治疗,实验组以中医辨证方法施治。对两组患者的疗效进行对比分析。结果:实验组患者的疗效明显优于对照组(P<0.05)。结论:相比于常规的西医治疗,中医辨证应用于慢性支气管炎肺气肿患者的临床治疗效果更佳,患者的临床症状明显改善,在临床治疗中应推广应用。%Objective: To analyze the clinical effect of TCM dialectical method applied to patients with chronic bronchitis and emphysema. Methods:80 cases of chronic bronchitis and emphysema in our hospital departments from May 2011 to October 2012 were randomly divided into two groups, 40 cases in each group. The control group treated with conventional modern medicine treatment, the experimental group was managed with TCM dialectical method differentiation. The efficacies of two groups were compared. Results:The experimental group were significantly better than the control group (P<0.05). Conclusion: Compared to conventional modern medicine, TCM medicine dialectical used in patients with chronic bronchitis and emphysema have better clinical treatment effect, the patient's clinical symptoms improved significantly, in the clinical treatment should be popularization and application.

  14. Research PM2.5 concentration on acute onset of chronic bronchitis%PM2.5浓度对老年慢性支气管炎急性发作的影响

    Institute of Scientific and Technical Information of China (English)

    翟文慧; 李勇; 路晶凯; 王伟; 黄志刚

    2015-01-01

    Objective To investigate the effect of PM2.5 concentration on acute onset of chronic bronchitis. Method The clinical data of Beijing city center and other areas were selected to monitor and record daily fine particulate air pollution around the station PM2.5, PM10 concentrations, and the average temperature, maximum temperature, minimum temperature, wind speed, relative humidity, barometric pressure, visibility seven meteorological factors. The number of cases of chronic bronchitis in patients with acute exacerbation everyday was recorded. Result ①Daily hospital visits attack was positively correlated with the concentration of PM2.5, with the average, maximum and minimum temperatures were negatively correlated, and the minimum temperature associated with relatively greater;same barometric pressure, relative humidity, wind speed and visibility were negatively correlated.②The number of acute exacerbation of chronic bronchitis as PM2.5 level increased and growth. Conclusion Acute exacerbation of chronic bronchitis affected by the concentration of PM2.5, PM2.5 concentration monitoring can play a role in early warning of the onset of senile acute and chronic respiratory diseases.%目的:探讨PM2.5浓度对老年慢性支气管炎急性发作的影响。方法选择北京市城市中心区及其他地区的患者资料,监测并记录每日医院周围大气细颗粒污染物PM2.5和PM10的浓度以及平均气温、最高气温、最低气温、风速、相对湿度、气压、能见度等7项气象因子。记录两地区每日老年慢性支气管炎急性发作患者例数。结果①每日住院的老年慢性支气管炎急性发作患者例数同PM2.5浓度呈正相关,同平均气温、最高气温、最低气温均呈负相关,且与最低气温相关度更大;同气压、相对湿度、风速及能见度均呈负相关。②老年慢性支气管炎急性发作患者例数随PM2.5等级升高而增多。结论老年慢性

  15. Analysis of Clinical Treatment of Chronic Bronchitis in Children%浅谈小儿慢性支气管炎临床治疗与措施

    Institute of Scientific and Technical Information of China (English)

    周巍

    2015-01-01

    Objective To study the clinical treatment of bronchitis in children and nursing. Methods 163 cases of bronchitis in children in our hospital from January 2012 to August 2014 were treated, retrospectively analyzed clinical data and treatment through, summarize treatment, care experience of bronchitis in children. Results After treatment, 104 patients were cured, 49 cases significantly improved, 10 cases transfer ed to higher level hospitals;the average discharge time of 6.5 days, clinical total ef iciency of 93.8%. The complication rate of 2.45%. Conclusion The clinical incidence of bronchitis in children, younger age, af ect growth in children. Clinical need to actively take antibiotics, fluids, oxygen comprehensive measures, with high-quality care, can significantly improve the cure rate.%目的分析研究小儿支气管炎的临床治疗方案及护理措施。方法选取我院2012年1月~2014年8月收治的支气管炎患儿163例,回顾性分析其临床资料及治疗经过,总结小儿支气管炎的治疗、护理经验。结果经治疗,有104例患儿治愈出院,49例明显好转,10例转上级医院;平均出院时间6.5d,临床总有效率高达93.8%。并发症发生率2.45%。结论小儿支气管炎临床发病率高,年龄小,影响小儿生长发育。临床治疗需积极采取抗感染、补液、吸氧综合措施,配合高质量护理,可显著提高治愈率。

  16. Nursing intervention of dog-days paste combined with cup moving on the treatment of chronic bronchitis patients%三伏贴敷配合走罐治疗慢性支气管炎患者的护理

    Institute of Scientific and Technical Information of China (English)

    刁喜华; 杨丽娟; 马芙蓉; 王晓信

    2015-01-01

    目的:观察用三伏贴敷配合走罐治疗慢性支气管炎的临床疗效及操作中的护理要点。方法根据“冬病夏治”理论,在三伏天进行穴位贴敷,并配合走罐治疗,在操作过程中观察护理重点。结果136例患者,临床治愈98例,好转28例,无效10例,总有效率为93%。结论三伏贴敷配合走罐治疗慢性支气管炎疗效明显,及时恰当护理不会发生水泡感染。%Objective To observe clinical curative and operation nursing of dog-days paste combined with cup moving therapy on the treatment of chronic bronchitis. Methods According to the theory of “winter disease cured in the summer”, we observed the operation key point nursing of acupoint sticking in the dog days of summer combined with cup moving. Results There were 98 cases of 136 patients presented cured, 28 cases improved, 10 cases no impact, so as the effective rate was 93%. Conclusions The nursing intervention of dog-days paste combined with cup moving can have a apparent curative effect on chronic bronchitis, and have no side effects of water vacuole infection if we nurse on time and appropriate.

  17. Characterisation of a collection of Streptococcus pneumoniae isolates from patients suffering from acute exacerbations of chronic bronchitis: in vitro susceptibility to antibiotics and biofilm formation in relation to antibiotic efflux and serotypes/serogroups.

    Science.gov (United States)

    Vandevelde, Nathalie M; Tulkens, Paul M; Diaz Iglesias, Yvan; Verhaegen, Jan; Rodriguez-Villalobos, Hector; Philippart, Ivan; Cadrobbi, Julie; Coppens, Nathalie; Boel, An; Van Vaerenbergh, Kristien; Francart, Hugo; Vanhoof, Raymond; Liistro, Giuseppe; Jordens, Paul; d'Odemont, Jean-Paul; Valcke, Yvan; Verschuren, Franck; Van Bambeke, Françoise

    2014-09-01

    The correlation between Streptococcus pneumoniae serotypes, biofilm production, antibiotic susceptibility and drug efflux in isolates from patients suffering from acute exacerbations of chronic bronchitis (AECB) remains largely unexplored. Using 101 isolates collected from AECB patients for whom partial (n=51) or full (n=50) medical details were available, we determined serotypes (ST)/serogroups (SG) (Quellung reaction), antibiotic susceptibility patterns [MIC (microdilution) using EUCAST and CLSI criteria] and ability to produce biofilm in vitro (10-day model; crystal violet staining). The majority of patients were 55-75 years old and pneumoniae. Moreover, 54% showed high severity scores (GOLD 3-4), and comorbidities were frequent including hypertension (60%), cancer (24%) and diabetes (20%). Alcohol and/or tobacco dependence was >30%. Isolates of SG6-11-15-23, known for large biofilm production and causing chronic infections, were the most prevalent (>15% each), but other isolates also produced biofilm (SG9-18-22-27 and ST8-20 being most productive), except SG7, SG29 and ST5 (fluoroquinolones and 2% for telithromycin. ST19A isolates showed resistance to all antibiotics, ST14 to all except moxifloxacin, and SG9 and SG19 to all except telithromycin, moxifloxacin and ceftriaxone (SG19 only). Solithromycin and telithromycin MICs were similar. No correlation was observed between biofilm production and MIC or efflux (macrolides, fluoroquinolones). S. pneumoniae serotyping may improve AECB treatment by avoiding antibiotics with predictable low activity, but it is not predictive of biofilm production.

  18. Effect of High Quality Nursing in Patients With Geriatric Chronic Bronchitis%老年慢性支气管炎应用优质化护理服务的效果研究

    Institute of Scientific and Technical Information of China (English)

    刘红

    2016-01-01

    目的:探讨优质化护理服务和传统护理在慢性支气管炎老年患者中应用的临床效果。方法选取我院2014年6月~2015年12月因慢性支气管炎需住院治疗的老年患者190例,按入院先后顺序分为两组,设定为观察组和对照组,每组各95例,观察组予以优质护理服务,对照组予以传统护理,比较两组护理后生活质量、幸福指数、疾病知晓度、治疗依从性、住院时间以及满意度。结果观察组生活质量中躯体疼痛评分低于对照组,生理功能、活力、精神健康评分高于对照组,幸福指数高于对照组,疾病知晓度和治疗依从性优于对照组,住院时间少于对照组,差异具有统计学意义(P<0.05);观察组非常满意率和总满意率高于对照组,差异具有统计学意义(P<0.05)。结论老年慢性支气管炎患者应用优质化护理服务临床效果较好,生活质量改善明显,依从性高,满意度高。%Objective To explore the effect of high quality nursing in patients with geriatric chronic bronchitis. Methods 190 cases of hospitalized elderly patients with chronic bronchitis in our hospital from June 2014 to December 2015 were divided into two groups according to admission order, set as the observation group and control group, 95 cases in each group, Observation group was given high quality nursing service, the control group was given traditional nursing. After nursing, the quality of life, happiness index, disease awareness, treatment adherence, length of hospital stay, and satisfaction in two groups were observed and compared. Results In observation group, body pain score of quality of life was lower than the control group, physiological function, energy, mental health score were higher than the control group, the happiness index was higher than the control group, the popularity and the treatment compliance were better than the control group, the length of hospital stay

  19. Clinical Analysis of Ambroxol Hydrochloride in Treatment of Chronic Bronchitis%盐酸氨溴索治疗慢性支气管炎的效果观察

    Institute of Scientific and Technical Information of China (English)

    张香平

    2015-01-01

    Objective Treatment and efficacy of ambroxol hydrochloride medicine in treatment of chronic bronchitis are to be investigated. Methods Chose 35 chronic bronchitis patients who are treated in hospital from July 2013 to November 2014 and separate them into study group and control group at random. 19 patients in study group were given ambroxol hydrochloride medicine treatment,while 16 patients in control group were given brombexine hydrochloride treatment,and then observed and compared treatment efficacy of the two groups. Results The result showed that the treatment efficacy in study group was 94.74%,while the treatment efficacy in control group was 75.0%,there was a treatment efficacy differential between the two groups,and such a differential had statistic value(P<0.05). Conclusion Ambroxol hydrochloride treatment is beneficial to relieve patients’symptoms of cough and asthma and improve their comfort feeling.%目的:探究慢性支气管患者采用盐酸氨溴索治疗的方法和效果。方法选取2013年7月~2014年11月收治的35例慢性支气管炎患者进行治疗,随机分组,实验组19例患者采用盐酸氨溴索,对照组16例患者选择必嗽平的治疗,观察两组患者的治疗效果。结果实验组患者治疗有效率为94.74%,对照组患者治疗有效率为75.0%。两组患者的治疗效果差异有统计学意义(P<0.05)。结论慢性支气管炎患者采用盐酸氨溴索的使用,能够缓解咳嗽、气喘等不良症状,提高身体舒适度。

  20. Winter disease summer treat acupoint sticking 68 cases of the treatment of chronic bronchitis curative effect observation and nursing care%冬病夏治穴位贴敷治疗慢性支气管炎68例疗效观察与护理

    Institute of Scientific and Technical Information of China (English)

    葛双阳; 丁小清

    2015-01-01

    Objective Winter disease summer treat acupoints were applied on the curative effect of chronic bronchitis.Methods The dog days of 68 cases of chronic bronchitis patients with acupoint sticking therapy. Results Clinical control 15 cases, 29 cases had marked effect, improvement in 19 cases, 5 cases were invalid, the total effective rate was 92.6%.Conclusions Winter disease summer acupoint sticking therapy cure chronic bronchitis has good effect, conform to the Chinese medicine Jane, and cheap, the characteristics of the test, can be used as an application of TCM appropriate technologies in community health posts.%目的:观察冬病夏治穴位贴敷对慢性支气管炎的疗效。方法:三伏天对68例慢性支气管炎患者进行穴位贴敷治疗。结果:临床控制15例,显效29例,好转19例,无效5例,总有效率92.6%。结论:冬病夏治穴位贴敷治疗慢性支气管炎有较好效果,符合中医简、便、廉、验的特点,可作为中医适宜技术在社区卫生站推广应用。

  1. 老年慢性支气管炎患者负性情绪及自尊感临床现状分析%Clinical analysis of negative emotions and self-esteem of elderly patients with chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    侯莉; 李家容; 王颖琦; 王玉兰

    2011-01-01

    目的:探讨老年慢性支气管炎患者负性情绪及自尊感的临床现状.方法:分别选取110例老年慢性支气管炎、110例慢性支气管炎非老年成人患者、110例正常体检健康成人依次设为观察组、对照组、正常对照组,均应用焦虑自评量表、Avillo的情绪情感形容词量表及Rosenberg自尊量表调查、比较其相关评分,比较不同临床特征观察组患者评分的差别.结果:观察组患者焦虑评分高于对照组、正常对照组(P<0.01),而情绪情感及自尊评分低于对照组、正常对照组(P<0.05,P<0.01);观察组患者焦虑、情绪情感及自尊评分与性别、婚姻状况、子女状况、经济收入密切相关(P<0.05);观察组患者焦虑与情绪情感评分具有负相关性(P<0.05),焦虑与自尊评分具有负相关性(P<0.01),情绪情感评分与自尊评分具有正相关性(P<0.05).结论:老年慢性支气管炎患者表现为明显的焦虑情绪、情绪情感水平下降、自尊感下降,尤其是女性、无配偶、子女不在身边及经济收入低的患者表现更明显,在临床中可针对此特点进行相关护理,从根源上提高其心理水平.%Objective: To analyze the clinical situation of negative emotions and self - esteem of elderly patients with chronic bronchitis. Methods: 110 elderly patients with chronic bronchitis, 110 non - elderly adult patients with chronic bronchitis and 110 healthy adults with routine physical examination were respectively selected and taken as the observation group, control group and normal control group. The anxiety self - rating scale, Avillo emotional adjective scale and Rosenberg self - esteem scale were used to conduct a survey and compare the scores and the different clinical features among the patients. Results: The anxiety scores were higher in the observation group than the control and normal control groups ( P <0. 01 ); emotion and self - esteem scores were lower in the observation

  2. Antibiotic prescribing for acute bronchitis

    DEFF Research Database (Denmark)

    Llor, Carl; Bjerrum, Lars

    2016-01-01

    INTRODUCTION: Acute bronchitis is a self-limiting infectious disease characterized by acute cough with or without sputum but without signs of pneumonia. About 90% of cases are caused by viruses. AREAS COVERED: Antibiotics for acute bronchitis have been associated with an approximately half...... discusses the reason for this antibiotic overprescription. Other therapies targeted to control symptoms have also demonstrated a marginal or no effect. EXPERT COMMENTARY: Clinicians should be aware of the marginal effectiveness of antibiotic therapy. Some strategies like the use of rapid tests, delayed...

  3. Research of B-tyepe natriuretic Peptide, blood gas analysis,and Pulmonary Function in Patients with Chronic Bronchitis,Chronic Obstructive Pulmonary Disease and Pulmonary Heart Disease%慢性支气管炎、COPD及肺心病患者BNP、肺功能和血气变化的研究

    Institute of Scientific and Technical Information of China (English)

    卜凡靖; 张红; 范磊; 刘伟

    2012-01-01

    Objective To explore the change of BNP ( B-type natriuretic peptide ), pulmonary function and blood gas analysis in patients with chronic bronchitis, rhronir obstructive pulmonary disease and pulmonary heart disease. Methods Vein blood was pumped from the patients with chronic bronchitis, chronic obstructive pulmonary disease and pulmonary heart disease, then testing plama BNP and pulmonary function, and artery blood was pumped for bood gas analysis. A contrastive study was performed among two groups and control group. Results From chronic bronchitis to chronic obstructive pulmonary disease and pulmonary heart disease, BNP tended to increase ( P < 0. 05 ). From chronic bronchitis to rhronir obstructive pulmonary disease and pulmonary heart disease, FE V, /FVC, MMEF tended to decrease ( both P < 0. 05 ), PaO, , PH tended to decrease, and PaCO, tended to increase ( allP < 0. 05 ). The BNP levels were negatively related with PaO2,PH(r= -0.69, - 0. 58 ,bothP <0. 01 ), and positively related with PaCO2( r = 0. 55 ,P < 0. 01 ). The BNP levels were negatively correlated with FEV,/FVC, MMEF( r = -0. 71 , -0. 68, bothP <0. 01 ). Conclusion The BNP levels had significant correlation with the blood analysis and pulmonary junction parameter. The BNP level may be an indicator in judging the prognosis of the COPD.%目的 探讨慢性支气管炎(慢支)、COPD、慢性肺源性心脏病(肺心病)患者不同时期BNP(B型钠尿肽)、肺功能、动脉血气的变化.方法 慢支、COPD、肺心病患者均空腹抽静脉血检测BNP;另抽动脉血检测血气;并行肺功能检测.三组间对比,并与正常组对照.结果 由慢支发展到COPD、肺心病时BNP逐渐升高(P<0.05);慢支、COPD及肺心病各组FEV1/FVC、MMEF逐渐降低(P均<0.05),动脉血氧分压(PaO2)、PH值逐渐降低,二氧化碳分压(PaCO2)逐渐增高(P均<0.05).BNP与PaO2、PH呈显著负相关(r=-0.69,-0.58,P均<0.01),而与PaCO2呈正相关(r=0.55,P<0.01).BNP与FEV1/FVC

  4. Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial.

    NARCIS (Netherlands)

    Decramer, M.; Rutten-van Molken, M.P.; Dekhuijzen, P.N.R.; Troosters, T.; Herwaarden, C.L.A. van; Pellegrino, R.; Schayck, C.P. van; Olivieri, D.; Donno, M. Del; Backer, W. de; Lankhorst, I.L.M.; Ardia, A.

    2005-01-01

    BACKGROUND: Increased oxidative stress is important in the pathogenesis of chronic obstructive pulmonary disease (COPD). We postulated that treatment with the antioxidant N-acetylcysteine would reduce the rate of lung-function decline, reduce yearly exacerbation rate, and improve outcomes. METHODS:

  5. 112例误诊为支气管炎的老年慢性咳嗽病因分析%Etiological investigation of the 112 elderly patients with chronic cough misdiagnosed as bronchitis

    Institute of Scientific and Technical Information of China (English)

    林芳; 王浩彦

    2012-01-01

    目的 探讨老年患者慢性咳嗽的误诊及病因分布.方法 基层医院误诊为支气管炎的112例老年慢性咳嗽患者,采用咳嗽诊治指南制定的诊断程序,判断病因并予针对性治疗.结果 最终病因明确107例(95.54%),其中单一病因为89例(79.46%),复合病因为18例(16.07%).老年患者病因诊断前三位为胃食管返流性咳嗽、咳嗽变异型哮喘 、上气道咳嗽综合征,在女性患者和男性患者中分别占26.39%,20.83%,18.06%和29.31%,22.41%,18.97%.三者占慢性咳嗽病因的67.69%,其次是ACEI诱发的咳嗽.经特异性治疗后咳嗽明显减轻或消失为103例,有效率为91.96%,其余均为部分缓解.结论 老年慢性咳嗽病因复杂常被误诊,规范慢性咳嗽病因诊断程序对提高老年慢性咳嗽诊治水平有重要意义.%Objective The purpose of this study is to explore the etiology and misdiagnosis of the elderly patients with chronic cough. Methods A total of 112 the elderly patients ( 62 females, 50 males ) with chronic cough misdiagnosed as bronchitis by primary hospital were studied. Based on " Guideline on Diagnosis and Treatment of Chronic Cough" established by China Medical, the causes of chronic cough would be confirmed and given specific therapy. Results 107 of 112 patients( 95. 54% )were finally confirmed. Chronic cough due to a single cause was found in 89 patients ( 79. 46% ), and due to two causes in 18 patients ( 16. 07% ). The top three causes were gastroesophageal reflux cough ( GERC ), cough variant asthma ( CVA ), upper airway cough syndrome ( UACS ) and accounted for 67. 69% , followed by the ACEI-induced cough. The three causes accounted for 26. 39% , 20. 83% , 18. 06% in females and 29. 31% , 22. 41% , 18. 97% in male patients, respectively. After specific therapy based on diagnosis, cough cured and alleviated in 103 patients (91. 96% ); the rest are partially alleviated. Conclusions The cause of chronic cough in the elderly is complex and often

  6. β-carotene protects rats against bronchitis induced by cigarette smoking

    Institute of Scientific and Technical Information of China (English)

    庞宝森; 王辰; 翁心植; 唐小奈; 张红玉; 牛淑洁; 毛燕玲; 辛平; 黄秀霞; 张海燕; 祝锦

    2003-01-01

    Objective To investigate the protective effects of β-carotene in rats against the development of chronic bronchitis induced by cigarette smoking. Results Long-term cigarette smoking caused an obvious increase in the amount of IL-6, IL-8 and LPO and a sharp decrease in the levels of NO and SOD in smoking animals compared to controls. β-carotene intake reversed all the changes induced by smoking and alleviated the pathological changes caused by chronic bronchitis. Conclusions Quantitative oral intake of β-carotene had protective effects against chronic bronchitis induced by long-term cigarette smoking, which was associated with the increased production of NO, the clearance of some oxidative free radicals (OFR) and the alleviation of chronic inflammation.

  7. Clinical Study on Xuanfei Ersansi Decoction in the Treatment of Chronic Bronchitis of Phlegm Dampness Invading Lung Syndrome%宣肺二三四汤治疗慢性支气管炎痰湿犯肺证临床研究

    Institute of Scientific and Technical Information of China (English)

    李艳蓉

    2013-01-01

    Objective:To observe clinical curative effect of Xuanfei Ersansi Decoction in the treatment of chronic bronchitis of phlegm-dampness invading the lung syndrome, Methods: 150 cases of chronic bronchitis were randomly divided into two groups;the treatment group of 75 cases was treated by Xuanfei Ersansi Decoction and 75 cases in the control group with aminophylline and ethidium bromide, 4weeks for one course. Results:The treatment group was significantly superior to the control group. The total effective rate was 93. 15% and 84.28% respectively and both groups had significant difference (P <0. 05). Conclusion: Xuanfei Ersansi Decoction has definite curative effects in treating chronic bronchitis of phlegm-dampness invading the lung syndrome.%目的:探讨宣肺二三四汤治疗慢性支气管炎痰湿犯肺证的临床疗效.方法:将150例慢性支气管炎患者随机分为两组,治疗组75例采用自拟宣肺二三四汤[方药组成:干姜、细辛、五味子、陈皮、法半夏(制)、茯苓、紫苏子、白芥子、莱菔子、党参、炒白术各10 g,黄芪15 g]治疗.对照组75例用氨茶碱及溴乙新,4周为1个疗程.结果:治疗组有效率为93.15%,对照组有效率为84.28%,两组比较有显著差异(P<0.05).结论:宣肺二三四汤治疗慢性支气管炎痰湿犯肺证疗效显著.

  8. Determination of Plasma L-selectin and Tumor Necrosis Factor-αConcentrations in Patients with Chronic Bronchitis and Its Clinical Values%慢性支气管炎患者血浆L-selectin和TNF-α的检测及临床价值

    Institute of Scientific and Technical Information of China (English)

    汪清

    2013-01-01

    Objective To explore plasma L-selectin and tumor necrosis factor-a levels in patients with chronic bronchitis and their clinical values were evaluated. Methods Ninety-eight patients and equal number of healthy controls were enrolled into this stud-y. Plasma L-selectin and tumor necrosis factor-a concentrations were measured by ELISA. Results Plasma L-selectin and TNF-α levels were markedly higher in patients with chronic bronchitis than those in healthy controls (all P<0.01) , and in acute exacerbation than in clinical recovery (all P<0.01). They were significantly associated with diverse variables of arterial blood gas (all P<0.01). Conclusion L-selectin and tumor necrosis factor-a are involved in the pathophysiological process of chronic bronchitis and their determination can be beneficial to evaluate severity and prognostication of chronic bronchitis.%目的:揭示慢性支气管炎患者血浆L-选择素(L-selectin)和肿瘤坏死因子-α(TNF-α)浓度的变化,探讨其临床价值.方法:收集慢性支气管炎患者和同期体检健康者各98例.ELISA检测血浆L-selectin和TNF-α浓度.结果:慢性支气管炎患者血浆L-selectin和TNF-α浓度均显著高于健康体检正常者(均P<0.01),急性发作期患者血浆L-selectin和TNF-α浓度均显著高于临床缓解期患者(均P<0.01),慢性支气管炎患者血浆L-selectin和TNF-α浓度与动脉血气指标显著相关(均P<0.01).结论:L-selectin和TNF-α参与慢性支气管炎的病理生理过程,指标测定有助于评估慢性支气管炎病情轻重及预后.

  9. Trends in Outpatient Visits with Benzodiazepines among US Adults With and Without Bronchitis or Chronic Obstructive Pulmonary Disease from 1999 to 2010.

    Science.gov (United States)

    Ford, Earl S; Wheaton, Anne G

    2015-01-01

    Little is known about trends in prescriptions for benzodiazepines among patients with chronic obstructive pulmonary disease (COPD). Our objective was to examine trends of office/outpatient department visits with a mention of a benzodiazepine made by patients aged ≥40 years with COPD in the United States. We used data from the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey from 1999-2010. From 1999 to 2010, the estimated numbers of office/outpatient department visits with a benzodiazepine mentioned increased from 20.7 million to 43.2 million among all patients, from 684,000 to 1.5 million among patients with COPD, and from 20.0 million to 41.7 million among patients without COPD. Using all 12-years of data, patients with COPD were more likely to have a visit with a mention of a benzodiazepine than patients without COPD (adjusted prevalence ratio = 1.48, 95% CI = 1.27-1.71).The unadjusted percentage of all office/outpatient department visits by patients with COPD with a mention of a benzodiazepine increased from 4.6% during 1999-2002 to 10.2% during 2007-2010 (P trend benzodiazepine by patients with COPD and all patients may have increased in the United States.

  10. Anti-inflammatory drugs and experimental bronchitis.

    Science.gov (United States)

    Jeffery, P K

    1986-01-01

    Chronic bronchitis (chronic hypersecretion) and chronic bronchiolitis (small airways disease) are two conditions associated with cigarette smoking: both contribute to airflow obstruction in man, the latter associated with progressive deterioration in lung function. Mucous metaplasia and hyperplasia are characteristic histological changes. Experimentally, cigarette smoke given daily for two weeks, induces similar histological changes in the airways of specific pathogen-free rats, providing a suitable animal model for study: an early proliferation of basal cells, accompanied by mucous metaplasia of surface epithelial serous cells is followed by proliferation of newly formed mucous cells. There is also a significant increase in epithelial thickness due to cell hypertrophy without stratification or prior ulceration. Experimentally, secretory cell hyperplasia is inhibited completely or to varying degrees by prophylactic administration (intraperitoneal injection) of either indomethacin, flurbiprofen, dexamethasone, prednisolone, hydrocortisone (each at 2 or 4 mg/kg body weight) or a mucolytic drug, N-acetylcysteine(Nac), given orally as a 1% solution of the drinking water. Nac also inhibits the associated mucus-hypersecretion. It takes between 21 and 84 days, depending on airway level, for the increase in secretory cell number to return to control values (ie recover). Indomethacin and flurbiprofen (4 mg/kg, by ip injection) shorten recovery to between 4 and 9 days in intrapulmonary airways but have no effect on recovery time in the rat trachea. Nac is effective in 6 of 7 airway levels which showed cigarette smoke-induced mucous cell hyperplasia. In conclusion, in the rat, the response to cigarette smoke is one of mucous cell metaplasia and both basal and mucous cell proliferation. Cigarette smoke-induced mucous cell hyperplasia can be inhibited when selected drugs are given concurrently with the cigarette smoke: indomethacin, fluriprofen and Nac are also therapeutic.

  11. Diagnosis and treatment of acute bronchitis.

    Science.gov (United States)

    Albert, Ross H

    2010-12-01

    Cough is the most common symptom bringing patients to the primary care physician's office, and acute bronchitis is usually the diagnosis in these patients. Acute bronchitis should be differentiated from other common diagnoses, such as pneumonia and asthma, because these conditions may need specific therapies not indicated for bronchitis. Symptoms of bronchitis typically last about three weeks. The presence or absence of colored (e.g., green) sputum does not reliably differentiate between bacterial and viral lower respiratory tract infections. Viruses are responsible for more than 90 percent of acute bronchitis infections. Antibiotics are generally not indicated for bronchitis, and should be used only if pertussis is suspected to reduce transmission or if the patient is at increased risk of developing pneumonia (e.g., patients 65 years or older). The typical therapies for managing acute bronchitis symptoms have been shown to be ineffective, and the U.S. Food and Drug Administration recommends against using cough and cold preparations in children younger than six years. The supplement pelargonium may help reduce symptom severity in adults. As patient expectations for antibiotics and therapies for symptom management differ from evidence-based recommendations, effective communication strategies are necessary to provide the safest therapies available while maintaining patient satisfaction.

  12. 酮替芬联合孟鲁司特治疗慢性喘息型支气管炎的疗效分析%Analysis of curative effect by ketotifen combined with montelukast in the treatment of chronic asthmatic bronchitis

    Institute of Scientific and Technical Information of China (English)

    李艳春

    2016-01-01

    Objective To analyze clinical effect by ketotifen combined with montelukast in the treatment of chronic asthmatic bronchitis. Methods A total of 105 patients with chronic asthmatic bronchitis were divided by different therapy into observation group (60 cases) and control group (45 cases). Both groups received conventional therapy, and the control group received additional montelukast, while the observation group received ketotifen combined with montelukast for treatment. Curative effects were compared between the two groups. Results The observation group had higher total effective rate as 95.00% than 80.00% of the control group, and the difference had statistical significance (P<0.05). Conclusion Implement of ketotifen combined with montelukast shows remarkably clinical effect in treating chronic asthmatic bronchitis. This method is safe and creditable, and it is worth clinical promotion.%目的:分析酮替芬联合孟鲁司特治疗慢性喘息型支气管炎的临床疗效。方法105例慢性喘息型支气管炎患者,根据治疗方法的不同分为观察组(60例)和对照组(45例 )。两组均给予常规治疗,对照组在常规治疗基础上加用孟鲁司特治疗,观察组在常规治疗基础上加用酮替芬联合孟鲁司特治疗。比较两组治疗效果。结果观察组总有效率为95.00%高于对照组的80.00%,差异具有统计学意义(P<0.05)。结论采用酮替芬联合孟鲁司特治疗慢性喘息型支气管炎的临床疗效显著,安全可靠,值得临床推广。

  13. Suhuang Capsule on Acute Attack of Senile Chronic Bronchitis the Curative Effects of the Patients With Observation%苏黄止咳胶囊对老年慢性支气管炎急性发作期患者的疗效观察

    Institute of Scientific and Technical Information of China (English)

    胡秋月

    2015-01-01

    ObjectiveTo investigate the clinical curative effect of Suhuangzhike capsule in the treatment of senile chronic bronchitis in acute attack period. MethodsSelected 124 cases of acute exacerbation of chronic bronchitis in senile patients as the research object, then they were randomly divided into control group and treatment group with 62 cases in each group, the control group was given conventional treatment, the treatment group used Suhuangzhike capsule treatment on the basis of conventional therapy, compared two groups of treatment effect.ResultsThe clinical effect of the treatment of the patients in the treatment group was significantly higher than the control group, with signiifcant difference (χ2=6.317,P<0.05).Conclusion The use of Suhuangzhike capsule in the treatment of elderly patients with chronic bronchitis in acute attack period, high security, good therapeutic effect, is worthy of clinical use.%目的:探讨苏黄止咳胶囊治疗老年慢性支气管炎急性发作期的临床疗效。方法选取124例慢性支气管炎急性发作期老年患者为研究对象,将其随机分为对照组和治疗组各62例,对照组给予常规治疗,治疗组在常规治疗的基础上采用苏黄止咳胶囊治疗,对比分析两组的治疗效果。结果治疗组患者临床治疗效果显著高于对照组,差异具有统计学意义(χ2=6.317,P<0.05)。结论采用苏黄止咳胶囊治疗处于慢性支气管炎急性发作期的老年患者,安全性高,治疗效果好,值得临床推广使用。

  14. Curative effect of bromhexine hydrochloride and glucose injection in the treatment of senile chronic bronchitis during the attack stage%盐酸溴己新葡萄糖注射液治疗老年慢性支气管炎发作期疗效观察

    Institute of Scientific and Technical Information of China (English)

    胡志润

    2016-01-01

    Objective:To observe the curative effect of bromhexine hydrochloride and glucose injection in the treatment of senile chronic bronchitis during the attack stage.Methods:96 cases of elderly patients with chronic bronchitis during the attack stage were divided into two groups randomly,with 48 cases in each group.The control group was given conventional comprehensive treatment,and the treatment group was given bromhexine hydrochloride and glucose injection treatment based on the control group. The clinical curative effect of the two groups was compared.Results:The total effective rate of the treatment group was 93.7%,and the total effective rate of the control group was 70.83%.The total effective rate of the treatment group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:Bromhexine hydrochloride and glucose injection in the treatment of senile chronic bronchitis during the attack stage had significant clinical curative effect.%目的:观察盐酸溴己新葡萄糖注射液治疗老年慢性支气管炎发作期疗效。方法:收治老年慢性支气管炎发作期患者96例,随机分成两组,每组48例。对照组给予常规综合治疗,治疗组在对照组基础上给予盐酸溴己新葡萄糖注射液治疗,比较两组临床疗效。结果:治疗组总有效率93.7%,对照组总有效率70.83%。治疗组总有效率明显高于对照组,差异具有统计学意义(P<0.05)。结论:盐酸溴己新葡萄糖注射液治疗老年慢性支气管炎发作期临床疗效显著。

  15. What Are the Signs and Symptoms of Bronchitis?

    Science.gov (United States)

    ... Are the Signs and Symptoms of Bronchitis? Explore Bronchitis What Is... Other Names Causes Who Is at Risk Signs & Symptoms Diagnosis Treatments Prevention Living With Clinical Trials Links Related Topics ...

  16. 六分钟步行试验在慢性支气管炎需做肺功能筛选中的价值%The value of six-minute walking test on chronic bronchitis needing lung function screening

    Institute of Scientific and Technical Information of China (English)

    陈根荣; 薛彦萍; 张梅红

    2009-01-01

    Objective To study the relationship between the six-minute walking test (6-MWT) and pulmonary function in the diagnosis course of chronic bronchitis converting into chronic obstructive pulmonary disease (COPD). Methods Pulmonary function was detected in 360 patients with chronic bronchitis.Based on the results and diagnosis standard of COPD by Chinese Medical Association in 2002, the patients were divided into COPD group and pulmonary function normal group.Tbe walking distance in 6-MWT (6-MWD) was measured, and the mean value of twice tests was calculated to study the correlation between 6-MWT and pulmonary function, and 50 healthy volunteers were selected as control group. Results Most 6-MWD in COPD group were less than 420 meters(95.95%, 142/148 ), but those in pulmonary function normal group were more than or equalled to 420 meters mostly (97.17%, 206/212 ). However in patients with the 6-MWD more than or equalled to 420 meters , pulmonary function indexes such as the ratio of forced expiratory volume in one second and forced vital capacity( FVC ), FEV_1%, maximal ventilatory volume(MVV)were all significantly greater than those in patients with 6-MWD less than 420 meters, and there were significant differences (P0.05 ). Conclusions 6-MWT is simple and feasible. However, it is a better indicator of the patients pulmonary function. The test would be an effective selecting examination for chronic bronchitis patients who are not willing to do puhnonary function test.%目的 探讨在慢性支气管炎发展为慢性阻塞性肺疾病(COPD)的诊断过程中,6min步行试验(6-MWT)与肺功能的相关性.方法 选择以慢性支气管炎就诊的患者360例,全部做肺功能检测,根据肺功能检测结果 ,符合2002年中华医学会COPD诊断标准,分为COPD组和肺功能正常组.同时做6-MWT,测定6 min步行距离(6-MWD),根据2次6-MWD取其平均值;研究肺功能与6-MWT的相关性,选择50例健康志愿者作对照(对照组).结果 COPD

  17. Acute Bronchitis - Multiple Languages: MedlinePlus

    Science.gov (United States)

    ... Somali) Bilingual PDF Health Information Translations Spanish (español) Bronquitis aguda Ukrainian (Українська) Bronchitis Бронхіт - Українська (Ukrainian) Bilingual ...

  18. Chronic Obstructive Pulmonary Disease (COPD) Includes: Chronic Bronchitis and Emphysema

    Science.gov (United States)

    ... Whooping Cough or Pertussis Family Life Marriage and Divorce Health Care and Insurance Access to Health Care ... Inflicted Injury Life Stages and Populations Age Groups Adolescent Health Child Health Infant Health Older Persons' Health ...

  19. 异丁司特缓释胶囊随机双盲双模拟治疗支气管哮喘或喘息性支气管炎%A double blind,double dummy,randomized,controlled trial of ibudilast sustained-release capsule in treatment of asthma or chronic as thmatic bronchitis

    Institute of Scientific and Technical Information of China (English)

    熊盛道; 刘辉国; 张珍祥; 徐永健

    2001-01-01

    Objective:To evaluate the efficacy and safety of ibudila st sustained-release capsule in treatment of asthma or chronic asthmatic bronch itis.Methods:80 patients with asthma or chronic asthmatic bronchitis w ere randomly allocated to receive twice daily 10 mg ibudilast sustained-release capsule for 6 weeks or three times daily 100 mg tranilast sustained-release ca psule for 6 weeks.Results:The total significantly effective rate,total effective rate,improvement in lung function and decrease in IgE value obtained were similar in both active and control groups.Conclusion:Ibudilast su stained-release capsule is an effective agent for treatment of asthma or chroni c asthmatic bronchitis.%目的:评价异丁司特缓释胶囊治疗支气管哮喘和慢性 喘息性支气管炎的疗效和安全性。方法:采用双盲双模拟随机平行对 照临床试验。试验组40例,口服异丁司特缓释胶囊10mg,bid,疗程6周。对照组40例,口服 曲尼司特胶囊100mg,tid,疗程6周。结果:试验组总显效率为67.5% ,总有效率为90.0%。肺功能显著改善17例,中度改善11例,改善8例。治疗分数明显低于试 验前(P<0.01)。IgE值治疗后比治疗前明显降低(P<0.01)。上述结果均与 对照 组相似。试验药物不良反应发生率为27.5%,且多为轻度反应,并可耐受。结论 :异丁司特缓释胶囊是一种安全有效的治疗支气管哮喘和慢性喘息性支气管炎的 药物。

  20. Inflammatory mechanisms and treatment of obstructive airway diseases with neutrophilic bronchitis.

    Science.gov (United States)

    Simpson, Jodie L; Phipps, Simon; Gibson, Peter G

    2009-10-01

    Obstructive airway diseases such as asthma and chronic obstructive pulmonary disease (COPD) are major global health issues. Although considered as distinct diseases, airway inflammation is a key underlying pathophysiological process in asthma, COPD and bronchiectasis. Persistent neutrophilic airway inflammation (neutrophilic bronchitis) occurs with innate immune activation and is a feature of each of these airway diseases. Little is known about the mechanisms leading to neutrophilic bronchitis and few treatments are effective in reducing neutrophil accumulation in the airways. There is a similar pattern of inflammatory mediator release and toll like receptor 2 expression in asthma, COPD and bronchiectasis. We propose the existence of an active amplification mechanism, an effector arm of the innate immune system, involving toll like receptor 2, operating in persistent neutrophilic bronchitis. Neutrophil persistence in the airways can occur through a number of mechanisms such as impaired apoptosis, efferocytosis and mucus hypersecretion, all of which are impaired in airways disease. Impairment of neutrophil clearance results in a reduced ability to respond to bacterial infection. Persistent activation of airway neutrophils may result in the persistent activation of the innate immune system resulting in further airway insult. Current therapies are limited for the treatment of neutrophilic bronchitis; possible treatments being investigated include theophylline, statins, antagonists of pro-inflammatory cytokines and macrolide antibiotics. Macrolides have shown great promise in their ability to reduce airway inflammation, and can reduce airway neutrophils, levels of CXCL8 and neutrophil proteases in the airways. Studies also show improvements in quality of life and exacerbation rates in airways diseases.

  1. A Fuzzy Rule-Base Model for Classification of Spirometric FVC Graphs in Chronical Obstructive Pulmonary Diseases

    Science.gov (United States)

    2007-11-02

    of distinguishing COPD group diseases (chronic bronchitis, emphysema and asthma ) by using fuzzy theory and to put into practice a “fuzzy rule-base...FVC Plots”. Keywords - asthma , chronic bronchitis, COPD (Chronic Obstructive Pulmonary Disease), emphysema , expert systems, FVC (forced vital...the group of chronic bronchitis, emphysema and asthma because of these reasons [4-7]. Additionally, similar symptoms may cause fuzziness in

  2. Acute bronchitis | EU Clinical Trials Register [EU Clinical Trials Register

    Lifescience Database Archive (English)

    Full Text Available dition(s) being investigated Acute bronchitis E.1.1.1Medical condition in easily understood language Acute b...LT E.1.2Classification code 10000687 E.1.2Term Acute bronchitis E.1.2System Organ Class 100000004862 E.1.3Co

  3. Risco aumentado de sintomas respiratórios e bronquite crônica em mulheres que utilizam biocombustíveis na Nigéria Increased risk of respiratory symptoms and chronic bronchitis in women using biomass fuels in Nigeria

    Directory of Open Access Journals (Sweden)

    Olufemi Olumuyiwa Desalu

    2010-08-01

    Full Text Available OBJETIVO: Determinar a associação de sintomas respiratórios e bronquite crônica com o uso de biocombustíveis entre mulheres habitantes de áreas rurais do estado de Ekiti, sudoeste da Nigéria. MÉTODOS: De janeiro a junho de 2009, realizou-se um estudo transversal com uma amostra de 269 mulheres adultas. Um questionário adaptado do European Community Respiratory Health Survey foi aplicado para a obtenção de dados sobre características sociodemográficas, tipo de combustível utilizado para a preparação de alimentos, sintomas respiratórios e história de tabagismo. Todas as participantes foram convidadas a realizar espirometria. RESULTADOS: Das 269 mulheres no estudo, 161 (59,9% utilizavam biocombustíveis para a preparação de alimentos. As mulheres que utilizavam biocombustíveis relataram mais sintomas respiratórios que aquelas que não os utilizavam - tosse (13,7% vs. 3,7%; sibilância (8,7% vs. 2,8%; dor no peito (7,5% vs. 1,9%; falta de ar (11,8% vs. 6,5%; sintomas nasais (9,3% vs. 4,6%; e bronquite crônica (10,6% vs. 2,8%. A análise multivariada por regressão logística confirmou que o uso de biocombustíveis está associado às seguintes variáveis: tosse (OR = 4,82; p = 0,01; bronquite crônica (OR = 3,75; p = 0,04; sibilância (OR = 2,22; p = 0,23; dor no peito (OR = 3,82; p = 0,09; falta de ar (OR = 1,54; p = 0,35; e sintomas nasais (OR = 2,32; p = 0,20. Todos os parâmetros espirométricos avaliados (VEF1, CVF, VEF1/CVF e PFE foram menores nas mulheres que utilizavam biocombustíveis do que naquelas que não os utilizavam. CONCLUSÕES: Nossos resultados enfatizam a necessidade de se substituir o uso de biocombustíveis nos domicílios pelo de um tipo de combustível atóxico, como eletricidade ou gás.OBJECTIVE: To determine whether respiratory symptoms and chronic bronchitis are associated with the use of biomass fuels (BMFs among women residing in rural areas of the Ekiti State, in southwestern Nigeria. METHODS

  4. Acupuncture as method of treatment and arresting progress of dust-induced bronchitis

    Energy Technology Data Exchange (ETDEWEB)

    Baburina, E.B.; Bykova, E.A.

    1983-10-01

    Acupuncture is an effective therapy for treatment of dust-induced bronchitis. It can be used independently or in combination with medicaments. Fifty men were divided into two groups of 20 and 30. One group was treated by acupuncture alone, the other with combined therapy. Acupuncture produced excellent results; combined treatment, good and satisfactory results. Since acupuncture reduced the possibility of complications, allergic reactions and side effects due to medication, it is an excellent means of preventing progress of dust-induced bronchitis. Patients experience 9 months remission of symptoms after treatment with acupuncture while medical therapy alone only relieves them for 1 to 1 1/2 months. Patients with chronic dust-induced bronchitis should receive a second course of acupuncture in 6 to 8 months to prevent recurrence of symptoms and progress of disease. Because of insufficient study of lasting effects of acupuncture, final conclusions about its effectiveness cannot be made, however, current evidence indicates it is a highly useful therapy. 6 references.

  5. Ribonucleoprotein of avian infectious bronchitis virus.

    Science.gov (United States)

    Davies, H A; Dourmashkin, R R; Macnaughton, M R

    1981-03-01

    The ribonucleoprotein (RNP) of avian infectious bronchitis virus (IBV) was examined by electron microscopy after shadowing with carbon/platinum. Linear RNP strands up to 6.7 microns in length, from three IVB strains, were sensitive to both pancreatic RNase and to proteases. These strands were obtained from spontaneously disrupted complete particles but not from disrupted incomplete particles that lacked RNP. They were also released from Nonidet P40-disrupted particles and could be isolated on sucrose density gradients at a density of 1.27 g/ml. In some cases, helical RNP complexes associated with virus particles were observed that were similar to RNPs of human coronavirus strain 229E and mouse hepatitis virus strain 3.

  6. An experimental study on the damage of endothelial cells of pulmonary vessels in a rat model of chronic bronchitis and emphysema%慢性支气管炎与肺气肿大鼠肺血管内皮细胞损伤的实验研究

    Institute of Scientific and Technical Information of China (English)

    郭韶梅; 钟小宁

    2010-01-01

    目的 研究慢性支气管炎(chronic bronchitis,CB)与肺气肿大鼠肺腺泡内肌型动脉(muscular artery,MA)内皮细胞(en-dothelial cell,ECs)损伤特点及红霉素(erythromycin,EM)的干预作用.方法 18只Wistar大鼠按随机数字表法分成3组:每组6只,正常对照组(A组),CB与肺气肿组(B组),EM治疗组(C组).用气管内注入脂多糖(lipopolysaccharide,LPS)及烟熏方法制作CB与肺气肿模型.8周后在电镜下观察肺腺泡内MA的ECs结构变化,光镜下观察肺腺泡内MA重塑改变.结果 (1)肺腺泡内MA的EC结构变化:与A组比较,B组肺腺泡内MA的EC变性肿大甚至坏死,胞浆内大量空泡,线粒体肿胀、数目减少.核突起、核异质增多.C组以上改变明显改善.(2)肺腺泡内MA图像分析:以内膜面积/血管总面积(%)描述,A组为21±4,B组为37±3,C组为30±1,三组间比较差异有统计学意义(P均<0.01).结论 (1)C8与肺气肿大鼠存在肺血管EC损伤.(2)肺血管EC损伤是CB与肺气肿大鼠肺血管重塑的重要病理基础.(3)EM对CB与肺气肿大鼠肺血管EC损伤及肺血管重塑有一定保护作用.

  7. A conservative treatment for plastic bronchitis in pediatric age.

    Science.gov (United States)

    Berlucchi, Marco; Pelucchi, Francesca; Timpano, Silviana; Zorzi, Annalisa; Padoan, Rita

    2014-01-01

    Plastic bronchitis is a rare disorder in pediatric age. This disease can cause life-threatening episodes. Broncoscopy plus bronchial lavage is considered the gold standard therapeutic technique. Knowledge of this disease is mandatory to perform correct diagnosis and provide prompt treatment. The authors report the history of a 5-year-old girl affected by plastic bronchitis who was successfully treated by a conservative therapy avoiding the traditional more invasive management.

  8. Targeted therapy of bronchitis in obstructive airway diseases.

    Science.gov (United States)

    Dasgupta, Angira; Neighbour, Helen; Nair, Parameswaran

    2013-12-01

    Guidelines for the management of obstructive airway diseases do not emphasize the measurement of bronchitis to indicate appropriate treatments or monitor response to treatment. Bronchitis is the central component of airway diseases and contributes to symptoms, physiological and structural abnormalities. It can be measured directly and reliably by quantitative assay of spontaneous or induced sputum. The measurement is reproducible, valid, and responsive to treatment and to changes in disease status. Bronchitis may be eosinophilic, neutrophilic, mixed, or paucigranulocytic (eosinophils and neutrophils not elevated). Eosinophilic bronchitis is usually a Th2 driven process and therefore a sputum eosinophilia of greater than 3% usually indicates a response to treatment with corticosteroids or novel therapies directed against Th2 cytokines such as IL-4, IL-5 and IL-13. Neutrophilic bronchitis which is a non-Th2 driven disease is generally a predictor of response to antibiotics and may be a predictor to therapies targeted at pathways that lead to neutrophil recruitment such as IL-8 (eg anti-CXCR2), IL-17 (eg anti-IL17) etc. Paucigranulocytic disease may not warrant anti-inflammatory therapy. Several novel monoclonals and small molecule antagonists have been evaluated in clinical trials with variable results and several more are likely to be discovered in the near future. The success of these agents will depend on appropriate patient selection by accurate phenotyping or characterization of bronchitis.

  9. Chronic Obstructive Pulmonary Disease (COPD)

    Science.gov (United States)

    ... term that is used to include chronic bronchitis, emphysema, or a combination of both conditions. Asthma is also a disease where it is difficult ... with COPD to also have some degree of asthma. What is chronic ... back to their original size. In emphysema, the walls of some of the alveoli have ...

  10. Etiology and immunology of infectious bronchitis virus

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    LF Caron

    2010-06-01

    Full Text Available Infectious bronchitis virus (IBV of chickens is currently one of the main diseases associated with respiratory syndrome in domestic poultry, as well as with losses related to egg production. The etiological agent is a coronavirus, which presents structural differences in the field, mainly in the S1 spike protein. The immune response against this virus is complicated by the few similarities among serotypes. Environmental and management factors, as well as the high mutation rate of the virus, render it difficult to control the disease and compromise the efficacy of the available vaccines. Bird immune system capacity to respond to challenges depend on the integrity of the mucosae, as an innate compartment, and on the generation of humoral and cell-mediated adaptive responses, and may affect the health status of breeding stocks in the medium run. Vaccination of day-old chicks in the hatchery on aims at eliciting immune responses, particularly cell-mediated responses that are essential when birds are first challenged. Humoral response (IgY and IgA are also important for virus clearance in subsequent challenges. The presence of antibodies against the S1 spike protein in 3- to 4-week-old birds is important both in broilers and for immunological memory in layers and breeders.

  11. Infectious Bronchitis Vaccination Protocols for Laying Hens

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    A. Sulaiman

    2011-12-01

    Full Text Available A research was conducted to investigate the effects of vaccination protocols for Infectious Bronchitis (IB on egg production, egg quality, and IB antibody titres of laying hens. Different initial vaccination (Control, VicS eye, VicS spray, VicS water, A3 eye, A3 spray, and A3 water for IB were administered to day-old Isa Brown hens. Half the hens were revaccinated regularly during lay whereas the other hens were not vaccinated. Results showed that initial vaccination treatment had significant effects on hen day egg production and egg quality of egg weight, shell reflectivity, shell breaking strength, shell thickness, albumen height, Haugh Units, and IB antibody titre levels, but had no effect on percentage of shell and yolk colour. Egg weight and shell reflectivity were less favourable in the control hens. In contrast, shell breaking strength and shell thickness were highest for the group that initially received A3 vaccine in water. However, regular revaccination had some deleterious effects on egg production and egg quality. There were no significant effects of revaccination on IB antibody titres. It is concluded that there was little advantage in regularly revaccinating laying hens for IB virus, since they had received appropriate initial vaccination.

  12. Lifetime occupational exposure to dusts, gases and fumes is associated with bronchitis symptoms and higher diffusion capacity in COPD patients.

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    Esther Rodríguez

    Full Text Available BACKGROUND: Occupational exposure to dusts, gases and fumes has been associated with reduced FEV1 and sputum production in COPD patients. The effect of occupational exposure on other characteristics of COPD, especially those reflecting emphysema, has not been studied in these patients. METHODS: We studied 338 patients hospitalized for a first exacerbation of COPD in 9 Spanish hospitals, obtaining full occupational history in a face-to-face interview; job codes were linked to a job exposure matrix for semi-quantitative estimation of exposure to mineral/biological dust, and gases/fumes for each job held. Patients underwent spirometry, diffusing capacity testing and analysis of gases in stable conditions. Quality of life, dyspnea and chronic bronchitis symptoms were determined with a questionnaire interview. A high- resolution CT scan was available in 133 patients. RESULTS: 94% of the patients included were men, with a mean age of 68(8.5 years and a mean FEV1% predicted 52 (16. High exposure to gases or fumes was associated with chronic bronchitis, and exposure to mineral dust and gases/fumes was associated with higher scores for symptom perception in the St. George's questionnaire. No occupational agent was associated with a lower FEV1. High exposure to all occupational agents was associated with better lung diffusion capacity, in long-term quitters. In the subgroup with CT data, patients with emphysema had 18% lower DLCO compared to those without emphysema. CONCLUSIONS: In our cohort of COPD patients, high exposure to gases or fumes was associated with chronic bronchitis, and high exposure to all occupational agents was consistently associated with better diffusion capacity in long-term quitters.

  13. Avian infectious bronchitis virus in Brazil: a highly complex virus meets a highly susceptible host population

    Directory of Open Access Journals (Sweden)

    PE Brandão

    2010-06-01

    Full Text Available Infectious bronchitis (IB is a highly aggressive disease for poultry in terms of symptoms and economic losses, and the control of this disease is difficult if flocks are not protected against type-specific challenges by the Avian infectious bronchitis virus (IBV. This article summarizes data presented by the author at the Workshop on Infectious Bronchitis 2009 on IB and IBV, including future developments on the field.

  14. Chronic pediatric pulmonary disease and primary humoral antibody based immune disease.

    Science.gov (United States)

    Dosanjh, A

    2011-04-01

    Chronic inflammation of the larger airways is a common occurrence in children. A number of factors such as younger age, premature birth, male gender, exposure to environmental smoke or pollution, and crowded housing can increase a child's susceptibility to chronic lung disease. Chronic bronchitis may be caused by an underlying humoral immunodeficiency if the clinical course is recurrent or prolonged. Primary humoral immunodeficiency accounts for approximately 70% of all immunodeficiencies. The differential of chronic bronchitis also includes Cystic Fibrosis, ciliary defects and immune cellular and phagocytic defects. This review will summarize the most common humoral antibody based immune based deficiencies associated with chronic pulmonary disease.

  15. Distribution of infectious bronchitis virus strains in different organs and evidence of vertical transmission in natural infection.

    Science.gov (United States)

    Pereira, Claiton Gonçalves; Saraiva, Giuliana Loreto; Vidigal, Pedro Marcus Pereira; Fietto, Juliana Lopes Rangel; Bressan, Gustavo Costa; Moreira, Maria Aparecida Scatamburlo; de Almeida, Márcia Rogéria; Júnior, Abelardo Silva

    2016-12-01

    On the basis of partial sequencing of the infectious bronchitis virus (IBV) S1 gene, this study investigated the molecular diversity of the virus in two life periods of a batch of breeding hens at the field level. The chicks were vaccinated against IBV on the second day of life with the vaccine Ma5, but at the age of 18 days, they exhibited clinical signs and macroscopic lesions compatible with avian infectious bronchitis (IB). In the clinical disease stage, the Ma5 vaccine strain was detected in the trachea, lungs, and small intestine of the chicks, while IBV variants were detected in the bursa of Fabricius and kidneys. Subsequently, new samples were collected from the same batch at the end of the production cycle. In this phase, the Ma5 vaccine strain was detected in the kidneys, small intestine, and oviduct of the hens. However, a previously unidentified IBV variant was found in the cecal tonsils. Additionally, a fragment of viral RNA with that was completely identical to the corresponding region of the Ma5 vaccine was detected in the allantoic fluid of viable embryos from the hens under study after 18 days of incubation. These findings suggest that, in addition to the Ma5 vaccine, other strains of IBV variants can coexist, seeming to establish a chronic infection in the chickens, and that they can potentially be transmitted vertically. These results may assist in immunoprophylaxis control programs against IBV.

  16. Europe: history, current situation and control measures for infectious bronchitis

    Directory of Open Access Journals (Sweden)

    RC Jones

    2010-06-01

    Full Text Available The emergence and nature of different strains of infectious bronchitis virus (IBV in Europe are described. Infectious bronchitis (IB is the most important endemic viral respiratory disease where highly pathogenic Newcastle disease and avian influenza are not present. IB was first described in the UK in 1948 and identified as Massachusetts type. In the 1970s and 80s new serotypes were reported in Holland and elsewhere and new vaccines were developed. The 1990s saw the emergence of the major variant commonly called 793B, again needing a new vaccine. Two novel types have been recognised since 2000, Italy 02 and QX. Italy 02 appears to be well controlled by the use of two different live vaccines (H120 and the 793B-related 4/91 while for QX, associated with nephritis in young birds and silent layers, new vaccines are in development. The use of two vaccines as above is a widely used protocol and is capable of protecting against a wide range of different types. Alternative approaches to IB vaccination are discussed. The importance of constant surveillance for prevalent and novel IBV types is emphasised and the value of experimental infections in chickens to determine the pathogenesis and pathology of new types in addition to testing efficacy of vaccines is outlined.

  17. Pathogenesis and Diagnostic Approaches of Avian Infectious Bronchitis

    Directory of Open Access Journals (Sweden)

    Faruku Bande

    2016-01-01

    Full Text Available Infectious bronchitis (IB is one of the major economically important poultry diseases distributed worldwide. It is caused by infectious bronchitis virus (IBV and affects both galliform and nongalliform birds. Its economic impact includes decreased egg production and poor egg quality in layers, stunted growth, poor carcass weight, and mortality in broiler chickens. Although primarily affecting the respiratory tract, IBV demonstrates a wide range of tissues tropism, including the renal and reproductive systems. Thus, disease outcome may be influenced by the organ or tissue involved as well as pathotypes or strain of the infecting virus. Knowledge on the epidemiology of the prevalent IBV strains in a particular region is therefore important to guide control and preventions. Meanwhile previous diagnostic methods such as serology and virus isolations are less sensitive and time consuming, respectively; current methods, such as reverse transcription polymerase chain reaction (RT-PCR, Restriction Fragment Length Polymorphism (RFLP, and sequencing, offer highly sensitive, rapid, and accurate diagnostic results, thus enabling the genotyping of new viral strains within the shortest possible time. This review discusses aspects on pathogenesis and diagnostic methods for IBV infection.

  18. Aerosolised heparin in the treatment of Fontan-related plastic bronchitis.

    Science.gov (United States)

    Eason, Daniel E; Cox, Kristin; Moskowitz, William B

    2014-02-01

    Patients with Fontan palliation and single-ventricle physiology encounter multiple comorbidities including plastic bronchitis, a disease characterised by the plugging of small and large airways by rubbery, white casts. To date, no controlled clinical trials have demonstrated effective treatment of plastic bronchitis. We report the application of aerosolised heparin, which has published success in non-cardiac-related pulmonary disease, for this complication in a Fontan patient.

  19. 呼吸训练与吸入类固醇提高慢性喘息型支气管炎患者肺功能的探讨%Respiratory training combined with inspiratory steroid hormone on pulmonary function of patients with asthmatic bronchitis

    Institute of Scientific and Technical Information of China (English)

    邹天士

    2001-01-01

    @@Background:Repeated cough,expectoration and asthma are main clinical manifestations of chronic asthmatic bronchitis,and pulmonary function is also affcted.Intraairway and around nonspecific inflammation are common in clinic.Steroid hormone could effectly treat nonspecific inflammation and hyperactivity of air way,and improve pulmonary function. Objective:To investigate effect of respiratory training and inspiratory steroid hormone on pumlonary function of patients with asthmatic bronchitis. Unit:Internal Respiratory oepartmant of the First People's Hospital of Zhaoqing Subjects:74 patients with athmatic bronchitis during 1998~ 2000,49 male,25 female aged 47~ 81 years(averagely 63.3 years),and disease course lasted for 2~ 21 years(averagely 12.6 years).

  20. The Relationships Between Weather and Climate and Attacks of Bronchitis

    Science.gov (United States)

    Talaia, M. A. R.; Saraiva, M. A. C.; Vieira da Cruz, A. A.

    The area of Aveiro, more concretely Aveiro lagoon, a natural laboratory has been con- sidered, for promoting the development and the application of several investigations worked. The importance of the influences of weather and climate on human health has been well known since ancient teams and many decisions concerning human be- haviour it are clearly weather related. However, decisions related to weather criteria can be important and economically significant, but the real economic effect of the weather is difficult to assess. Talaia et al. (2000) and Talaia and Vieira da Cruz (2001) have shown the possible harmful effect of certain meteorological factors on respiratory conditions. Bronchitis is a disease caused by inflammation of the bronchi as a result of infectious agents or air pollutants. In this study our attention is to relate, the be- ginning of bronchitis attacks in the services of urgency of the Hospital of Aveiro with meteorological factors, and the risk group are studied. We used the medical records and the database of meteorological factors. The obtained analysis allows to conclude that some meteorological factors have correlation with the occurrences of the disease and to allow improving the work in the urgency services in the requested periods. The knowledge that will be extracted of this study can be used later in studies that inte- grate other important components for the characterisation of the environmental impact in the area. References: Talaia, M.A.R., Vieira da Cruz, A.A., Saraiva, M.A.C., Amaro, G.S., Oliveira, C.J. and Carvalho, C.F., 2000, The Influence of Meteorological Fac- tors on Pneumonia Emergencies in Aveiro, International Symposium on Human- Biometeorology, St. Petersburg (Pushkin), Russia, pp. 67-68. Talaia, M.A.R. and Vieira of Cruz, A.A., (2001), Meteorological Effects on the Resistance of the Body to Influenza - One Study in Aveiro Region, Proceedings 2nd Symposium of Meteorol- ogy and Geophysics of APMG and 3rd Meeting

  1. Approaching chronic cough.

    Science.gov (United States)

    Poulose, Vijo; Tiew, Pei Yee; How, Choon How

    2016-02-01

    Chronic cough is one of the most common reasons for referral to a respiratory physician. Although fatal complications are rare, it may cause considerable distress in the patient's daily life. Western and local data shows that in patients with a normal chest radiograph, the most common causes are postnasal drip syndrome, postinfectious cough, gastro-oesophageal reflux disease and cough variant asthma. Less common causes are the use of angiotensin-converting enzyme inhibitors, smoker's cough and nonasthmatic eosinophilic bronchitis. A detailed history-taking and physical examination will provide a diagnosis in most patients, even at the primary care level. Some cases may need further investigations or specialist referral for diagnosis.

  2. Genetic diversity and selection regulates evolution of infectious bronchitis virus.

    Science.gov (United States)

    Toro, Haroldo; van Santen, Vicky L; Jackwood, Mark W

    2012-09-01

    Conventional and molecular epidemiologic studies have confirmed the ability of infectious bronchitis virus (IBV) to rapidly evolve and successfully circumvent extensive vaccination programs implemented since the early 1950s. IBV evolution has often been explained as variation in gene frequencies as if evolution were driven by genetic drift alone. However, the mechanisms regulating the evolution of IBV include both the generation of genetic diversity and the selection process. IBV's generation of genetic diversity has been extensively investigated and ultimately involves mutations and recombination events occurring during viral replication. The relevance of the selection process has been further understood more recently by identifying genetic and phenotypic differences between IBV populations prior to, and during, replication in the natural host. Accumulating evidence suggests that multiple environmental forces within the host, including immune responses (or lack thereof) and affinity for cell receptors, as well as physical and biochemical conditions, are responsible for the selection process. Some scientists have used or adopted the related quasispecies frame to explain IBV evolution. The quasispecies frame, while providing a distinct explanation of the dynamics of populations in which mutation is a frequent event, exhibits relevant limitations which are discussed herein. Instead, it seems that IBV populations evolving by the generation of genetic variability and selection on replicons follow the evolutionary mechanisms originally proposed by Darwin. Understanding the mechanisms underlying the evolution of IBV is of basic relevance and, without doubt, essential to appropriately control and prevent the disease.

  3. Proteomic analysis of purified coronavirus infectious bronchitis virus particles

    Directory of Open Access Journals (Sweden)

    Shu Dingming

    2010-06-01

    Full Text Available Abstract Background Infectious bronchitis virus (IBV is the coronavirus of domestic chickens causing major economic losses to the poultry industry. Because of the complexity of the IBV life cycle and the small number of viral structural proteins, important virus-host relationships likely remain to be discovered. Toward this goal, we performed two-dimensional gel electrophoresis fractionation coupled to mass spectrometry identification approaches to perform a comprehensive proteomic analysis of purified IBV particles. Results Apart from the virus-encoded structural proteins, we detected 60 host proteins in the purified virions which can be grouped into several functional categories including intracellular trafficking proteins (20%, molecular chaperone (18%, macromolcular biosynthesis proteins (17%, cytoskeletal proteins (15%, signal transport proteins (15%, protein degradation (8%, chromosome associated proteins (2%, ribosomal proteins (2%, and other function proteins (3%. Interestingly, 21 of the total host proteins have not been reported to be present in virions of other virus families, such as major vault protein, TENP protein, ovalbumin, and scavenger receptor protein. Following identification of the host proteins by proteomic methods, the presence of 4 proteins in the purified IBV preparation was verified by western blotting and immunogold labeling detection. Conclusions The results present the first standard proteomic profile of IBV and may facilitate the understanding of the pathogenic mechanisms.

  4. Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control study.

    Directory of Open Access Journals (Sweden)

    Jill Koshiol

    Full Text Available BACKGROUND: Chronic obstructive pulmonary disease (COPD has been consistently associated with increased risk of lung cancer. However, previous studies have had limited ability to determine whether the association is due to smoking. METHODOLOGY/PRINCIPAL FINDINGS: The Environment And Genetics in Lung cancer Etiology (EAGLE population-based case-control study recruited 2100 cases and 2120 controls, of whom 1934 cases and 2108 controls reported about diagnosis of chronic bronchitis, emphysema, COPD (chronic bronchitis and/or emphysema, or asthma more than 1 year before enrollment. We estimated odds ratios (OR and 95% confidence intervals (CI using logistic regression. After adjustment for smoking, other previous lung diseases, and study design variables, lung cancer risk was elevated among individuals with a history of chronic bronchitis (OR = 2.0, 95% CI = 1.5-2.5, emphysema (OR = 1.9, 95% CI = 1.4-2.8, or COPD (OR = 2.5, 95% CI = 2.0-3.1. Among current smokers, association between chronic bronchitis and lung cancer was strongest among lighter smokers. Asthma was associated with a decreased risk of lung cancer in males (OR = 0.48, 95% CI = 0.30-0.78. CONCLUSIONS/SIGNIFICANCE: These results suggest that the associations of personal history of chronic bronchitis, emphysema, and COPD with increased risk of lung cancer are not entirely due to smoking. Inflammatory processes may both contribute to COPD and be important for lung carcinogenesis.

  5. Purine Bases in Blood Plasma of Patients with Chronic Pulmonary Diseases

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    Larissa E. Muravluyova

    2012-09-01

    Full Text Available The article is focused on the study of purine bases and intermediates of purine catabolism in plasma of patients with chronic obstructive bronchitis and idiopathic interstitial pneumonia. Decrease of adenine and hypoxantine in plasma of patients with idiopathic interstitial pneumonia was registered. Increase of guanine in plasma of patients with chronic obstructive pulmonary disease was established.

  6. Management of plastic bronchitis with topical tissue-type plasminogen activator.

    Science.gov (United States)

    Gibb, Elizabeth; Blount, Robert; Lewis, Nancy; Nielson, Dennis; Church, Gwynne; Jones, Kirk; Ly, Ngoc

    2012-08-01

    Plastic bronchitis or cast bronchitis is a rare disease of unclear etiology characterized by formation of airway casts that can lead to life-threatening airway obstruction. There is currently limited data regarding optimal treatment of plastic bronchitis. Several therapies have been suggested, but recurrences are common and mortality remains high. We report the case of a 6-year-old boy with refractory eosinophilic bronchial casts, unresponsive to low-dose systemic corticosteroids, inhaled corticosteroids, azithromycin, and dornase alfa, who was treated successfully and safely with direct instillation of tissue-type plasminogen activator (tPA) to the obstructing casts during flexible bronchoscopy and inhaled tPA. Our case illustrates that the current therapy for plastic bronchitis remains inadequate. To our knowledge, this case is the first to show that direct instillation of tPA can be used safely for treatment of this disease. The use of tPA via direct administration into the airways during bronchoscopy and via a nebulizer appeared to be a safe and effective therapy for plastic bronchitis and should be considered early in the course of the disease to prevent complications of severe airway obstruction.

  7. Lactate dehydrogenase concentration in nasal wash fluid indicates severity of rhinovirus-induced wheezy bronchitis in preschool children.

    Science.gov (United States)

    Cangiano, Giulia; Proietti, Elena; Kronig, Marie Noelle; Kieninger, Elisabeth; Sadeghi, Christine D; Gorgievski, Meri; Barbani, Maria Teresa; Midulla, Fabio; Tapparel, Caroline; Kaiser, Laurent; Alves, Marco P; Regamey, Nicolas

    2014-12-01

    The clinical course of rhinovirus (RV)-associated wheezing illnesses is difficult to predict. We measured lactate dehydrogenase concentrations, RV load, antiviral and proinflammatory cytokines in nasal washes obtained from 126 preschool children with RV wheezy bronchitis. lactate dehydrogenase values were inversely associated with subsequent need for oxygen therapy. lactate dehydrogenase may be a useful biomarker predicting disease severity in RV wheezy bronchitis.

  8. Can eosinophilic bronchitis be considered as an occupational disease? Medical certification aspects

    Directory of Open Access Journals (Sweden)

    Aneta Kleniewska

    2013-08-01

    Full Text Available Eosinophilic bronchitis (EB is a condition which can be associated with occupational exposure to low, as well as to high molecular weight allergens. The prevalence of occupational eosinophilic bronchitis is unknown and the data concerning its work-related etiology are available only from the case reports. However, there is a need to establish the principles, especially in the context of medical certification among workers occupationally exposed to allergens. This paper reviews current knowledge on the etiology, clinical features, and diagnostic procedures in the eosinophilic bronchitis. The importance of EB, especially in view of the problems emerging in the prophylactic care taken by occupational health services and the principles of medical certification when occupational etiology is suspected are also presented. Med Pr 2013;64(4:569–578

  9. Interference of infectious bursal disease virus on antibody production against Newcastle disease and infectious bronchitis virus

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    WM Cardoso

    2006-09-01

    Full Text Available This work has the objective of verifying the interference of infectious bursal disease virus in the antibody production against Newcastle disease virus and infectious bronchitis virus. The experiment was carried out with 640 day-old-chicks from a 42 weeks old hen flock. The birds were separated into eight experimental groups (n=80/group and were submitted to different combinations of vaccinations, with live vaccines, to Newcastle disease, avian infectious bronchitis, and infectious bursal disease with diverse combinations of days of vaccination. We verified that the utilization of polyvalent vaccinal programs have a different efficacy comparing to monovalent vaccinations when Newcastle disease, infectious bronchitis, and infectious bursal disease vaccinations are applied. This way, the use of vaccinations to infectious bursal disease in polyvalent vaccinal programs is desirable due to improvement of NDV response with the presence of IBV by the probable reduction of interference of IBV under NDV.

  10. Chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    V K Vijayan

    2013-01-01

    Full Text Available The global prevalence of physiologically defined chronic obstructive pulmonary disease (COPD in adults aged >40 yr is approximately 9-10 per cent. Recently, the Indian Study on Epidemiology of Asthma, Respiratory Symptoms and Chronic Bronchitis in Adults had shown that the overall prevalence of chronic bronchitis in adults >35 yr is 3.49 per cent. The development of COPD is multifactorial and the risk factors of COPD include genetic and environmental factors. Pathological changes in COPD are observed in central airways, small airways and alveolar space. The proposed pathogenesis of COPD includes proteinase-antiproteinase hypothesis, immunological mechanisms, oxidant-antioxidant balance, systemic inflammation, apoptosis and ineffective repair. Airflow limitation in COPD is defined as a postbronchodilator FEV1 (forced expiratory volume in 1 sec to FVC (forced vital capacity ratio <0.70. COPD is characterized by an accelerated decline in FEV1. Co morbidities associated with COPD are cardiovascular disorders (coronary artery disease and chronic heart failure, hypertension, metabolic diseases (diabetes mellitus, metabolic syndrome and obesity, bone disease (osteoporosis and osteopenia, stroke, lung cancer, cachexia, skeletal muscle weakness, anaemia, depression and cognitive decline. The assessment of COPD is required to determine the severity of the disease, its impact on the health status and the risk of future events (e.g., exacerbations, hospital admissions or death and this is essential to guide therapy. COPD is treated with inhaled bronchodilators, inhaled corticosteroids, oral theophylline and oral phosphodiesterase-4 inhibitor. Non pharmacological treatment of COPD includes smoking cessation, pulmonary rehabilitation and nutritional support. Lung volume reduction surgery and lung transplantation are advised in selected severe patients. Global strategy for the diagnosis, management and prevention of Chronic Obstructive Pulmonary Disease

  11. Lung Compliance and Chronic Obstructive Pulmonary Disease

    Directory of Open Access Journals (Sweden)

    D. Papandrinopoulou

    2012-01-01

    Full Text Available Chronic obstructive pulmonary disease, namely, pulmonary emphysema and chronic bronchitis, is a chronic inflammatory response of the airways to noxious particles or gases, with resulting pathological and pathophysiological changes in the lung. The main pathophysiological aspects of the disease are airflow obstruction and hyperinflation. The mechanical properties of the respiratory system and its component parts are studied by determining the corresponding volume-pressure (P-V relationships. The consequences of the inflammatory response on the lung structure and function are depicted on the volume-pressure relationships.

  12. Airway distensibility in Chronic Obstructive Airway Disease

    DEFF Research Database (Denmark)

    Winkler Wille, Mathilde Marie; Pedersen, Jesper Holst; Dirksen, Asger

    2013-01-01

    -20% (mild), 20%-30% (moderate) or >30% (severe). Spirometry was performed annually and participants were divided into severity groups according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD). Data were analysed in a mixed effects regression model with log(airway lumen diameter......Rationale – Chronic Obstructive Pulmonary Disease (COPD) is a combination of chronic bronchitis and emphysema, which both may lead to airway obstruction. Under normal circumstances, airway dimensions vary as a function of inspiration level. We aim to study the influence of COPD and emphysema...... in causing airway narrowing, the latter most likely due to loss of elastic recoil of surrounding tissue....

  13. ANESTHETIC CONSIDERATION S IN CHRONIC OBSTRUCTIVE PULMON ARY DISEASE

    Directory of Open Access Journals (Sweden)

    Awati

    2015-03-01

    Full Text Available Chronic obstructive pulmonary disease (COPD is a spectrum of diseases that includes emphysema, chronic bronchitis, and small airway disease. It i s characterized by progressive increased resistance to breathing. Patients with marked obstructive pulmonary disease are at increased risk for both intraoperative and Postoperative pulmonary complications. These patients require thorough preoperative prepa ration, meticulous intraoperative management & postoperative care. This article describes anesthetic considerations in a patient with COPD.

  14. Pharmacotherapy challenges of Fontan-associated plastic bronchitis: a rare pediatric disease.

    Science.gov (United States)

    Brooks, Kristina; Caruthers, Regine L; Schumacher, Kurt R; Stringer, Kathleen A

    2013-09-01

    Pediatric pharmacotherapy is often challenging due to the paucity of available clinical data on the safety and efficacy of drugs that are commonly used in children. This quandary is even more prevalent in children with rare diseases. Although extrapolations for dosing and administration are often made from available adult data with similar disease states, this translation becomes even more problematic in rare pediatric diseases. Understanding of rare disease pathophysiology is typically poor, and few, if any, effective therapies have been studied and identified. One condition that illustrates these issues is plastic bronchitis, a rare, most often pediatric disease that is characterized by the production of obstructive bronchial airway casts. This illness primarily occurs in children with congenital heart disease, often after palliative surgery. Plastic bronchitis is a highly clinically relevant and therapeutically challenging problem with a high mortality rate, and, a generally accepted effective pharmacotherapy regimen has yet to be identified. Furthermore, the disease is ill defined, which makes timely identification and treatment of children with plastic bronchitis difficult. The pharmacotherapies currently used to manage this disease are largely anecdotal and vary between the use of macrolide antibiotics, mucolytics, bronchodilators, and inhaled fibrinolytics in a myriad of combinations. The purpose of this review is 2-fold: first, to highlight the dilemma of treating plastic bronchitis, and second, to bring attention to the continuing need for studies of drug therapies used in children so safe and effective drug regimens can be established, particularly for rare diseases.

  15. Association between Ambient Air Pollution and Outpatient Visits for Acute Bronchitis in a Chinese City

    Institute of Scientific and Technical Information of China (English)

    GUO Li Juan; ZHAO Ang; CHEN Ren Jie; KAN Hai Dong; KUANG Xing Ya

    2014-01-01

    Objective To investigate the short-term association between outdoor air pollution and outpatient visits for acute bronchitis, which is a rare subject of research in the mainland of China. Methods A time-series analysis was conducted to examine the association of outdoor air pollutants with hospital outpatient visits in Shanghai by using two-year daily data (2010-2011). Results Outdoor air pollution was found to be associated with an increased risk of outpatient visits for acute bronchitis in Shanghai. The effect estimates of air pollutants varied with the lag structures of the concentrations of the pollutants. For lag06, a 10μg/m3 increase in the concentrations of PM10, SO2, and NO2 corresponded to 0.94%(95%CI:0.83%, 1.05%), 11.12%(95%CI:10.76%, 11.48%), and 4.84%(95%CI: 4.49%, 5.18%) increases in hospital visits for acute bronchitis, respectively. These associations appeared to be stronger in females (P Conclusion Our analyses have provided the first evidence that the current air pollution level in China has an effect on acute bronchitis and that the rationale for further limiting air pollution levels in Shanghai should be strengthened.

  16. Successful treatment of plastic bronchitis with low fat diet and subsequent thoracic duct ligation in child with fontan physiology.

    Science.gov (United States)

    Parikh, K; Witte, M H; Samson, R; Teodori, M; Carpenter, J B; Lowe, M C; Morgan, W; Hardin, C; Brown, M; Naughton, Y; Sinha, S; Barber, B J

    2012-06-01

    Plastic bronchitis is a rare condition characterized by the formation and expectoration of long, branching bronchial casts that develop in the tracheobronchial tree and cause airway obstruction. Plastic bronchitis has become increasingly recognized as a feared complication of the Fontan operation with a mortality of up to 50%. We report an 11 year old boy who developed severe plastic bronchitis following Fontan repair and the successful long-term control of cast formation utilizing a low-fat diet and subsequent thoracic duct ligation.

  17. 嗜酸粒细胞性支气管炎的研究进展%Research advences of eosinophilic bronchitis

    Institute of Scientific and Technical Information of China (English)

    孙晓远; 周新

    2014-01-01

    Eosinophilic bronchitis (EB) is one of the major causes of chronic cough.It is now showing a gradually rising morbidity,which accouts for 17.2% in our country as reported in a recent study published on Chest.EB is characterized by chronic cough in the presence of normal pulmonary imaging,normal spirometry,normal peak expiratory flow variability,and also in the absence of airway hyper-responsiveness.It is usually distinguished from others by induced sputum eosinophilia.As regard to treatments,corticosteroids is the first-line pharmacotherapy.Until now,the etiology and pathogenesis of EB still remains unclear.The aim of this article is to review the epidemiology,etiology,pathophysiology,pathogenesis,diagnosis,treatment and prognosis of this condition.%嗜酸粒细胞性支气管炎(eosinophilic bronchitis,EB)是慢性咳嗽的主要病因之一,近年来其发病率呈上升趋势,国内其发病率为17.2%.EB是以慢性咳嗽为主要症状,其特点是肺部影像学、肺功能、气道反应性、PEF日间变异率均正常,而诱导痰嗜酸粒细胞比例增高,糖皮质激素治疗有效.病因尚不清楚,发病机制有待进一步研究.本文对EB的流行病学、病因、病理表现、发病机制、诊断、治疗和预后作一综述.

  18. Persistent pathogens as risk factors of community-acquired pneumonia and acute bronchitis in children

    Directory of Open Access Journals (Sweden)

    O. V. Zhukova

    2016-01-01

    Full Text Available The aim of this study was to determine the relationship between infection with “persistent” agents of children and the possibility of the development of inflammatory diseases of the respiratory tract such as community-acquired pneumonia and acute bronchitis on the basis of risk management concepts.Materials and methods. 701 children in age from 15 days to 16 years were examined in Nizhny Novgorod and the Nizhny Novgorod region with clinically and radiologically confirmed diagnosis: community-acquired pneumonia, acute bronchitis. This study was performed in the period from 2005 to 2014. The control group consisted of 127 healthy children of different ages. The detection of M. pneumoniae, Сytomegalovirus, Herpes simplex I/II C. pneumoniae was performed by PCR. The concept of risk determination was based on the determination of the absolute risk in the exposed and the no exposed groups, attributable risk, relative risk, the population attributable risk, as well as determining the standard errors for each type of risk and confidence interval.Results. Attributable risk, relative risk, population-attributable risk are statistically significant figures. Attributable risk of development of community-acquired pneumonia was 29,26%; 27,37%; 25,70%; 20,21% for the M. pneumoniae, C. pneumoniae, CMV, HSV I / II respectively. The relative risk was 1,43 for the M. pneumoniae; 1,38 – for C. pneumoniae and CMV; 1,28- for HSV I / II. The presence of persistent pathogens is resulting in increased incidence of communityacquired pneumonia throughout the population (population attributable risk: 4,75% for M. pneumoniae, 0,23% for C. pneumoniae, 5,59% for the CMV and 1,08% for the HSV I/II. Similar calculations were performed for patients with acute bronchitis. The statistical analysis allowed to exclude C. pneumoniae and HSV I / II of the risk factors for communityacquired pneumonia and acute bronchitis.Conclusion. The findings suggest the influence of M

  19. [Diagnosis of predisposition to chronic cor pulmonale formation in occupational lung diseases caused by dust].

    Science.gov (United States)

    Panev, N I; Korotenko, O Iu; Zakharenkov, V V; Korchagina, Iu S; Gafarov, N I

    2014-01-01

    Study covered 426 miners aged 40-54 years with previously diagnosed occupational respiratory diseases due to dust (246 patients with chronic occupational obstructive bronchitis, 98 with anthracosilicosis and 82 with chronic dust nonobstructive bronchitis). 315 (73.9%) examinees out of 426 with lung diseases due to dust demonstrated chronic cor pulnmonale. Considering high share of this complication, the authors used Bayes method to create a method to diagnose predisposition towards chronic cor pulmonale in patients with dust lung diseases through respiratory failure, concomitant coronary heart disease and arterial hypertension, blood groups ABO, MN and P, some structural and functional parameters of heart: myocardium weight index, relative wall thickness index and left ventricle sphericity index, average lung artery pressure. Increasing number of analyzed factors that directly influence chronic cor pulmonale development and selecting additional markers help to improve forecasting of the complication.

  20. Cardiovascular Complications in Chronic Obstructive Pulmonary Disease with Reference to 2D Echocardiography Findings

    Directory of Open Access Journals (Sweden)

    Vikram B Vikhe

    2013-08-01

    Results: Emphysema and chronic bronchitis was present in 38% and 62% respectively. Echocardiographic evidence of cor-pulmonale and pulmonary hypertension was found in 70% of the patients. Conclusions: Echocardiography is more sensitive than electrocardiography in detecting PAH and right ventricular dysfunction in COPD. [Natl J Med Res 2013; 3(4.000: 385-388

  1. Pediatric Plastic Bronchitis: Case Report and Retrospective Comparative Analysis of Epidemiology and Pathology

    Directory of Open Access Journals (Sweden)

    Rebecca Kunder

    2013-01-01

    Full Text Available Plastic bronchitis (PB is a pathologic condition in which airway casts develop in the tracheobronchial tree causing airway obstruction. There is no standard treatment strategy for this uncommon condition. We report an index patient treated using an emerging multimodal strategy of directly instilled and inhaled tissue plasminogen activator (t-PA as well as 13 other cases of PB at our institution between 2000 and 2012. The majority of cases (n=8 occurred in patients with congenital heart disease. Clinical presentations, treatments used, histopathology of the casts, and patient outcomes are reviewed. Further discussion is focused on the epidemiology of plastic bronchitis and a systematic approach to the histologic classification of casts. Comorbid conditions identified in this study included congenital heart disease (8, pneumonia (3, and asthma (2. Our institutional prevalence rate was 6.8 per 100,000 patients, and our case fatality rate was 7%.

  2. Successful treatment of severe asthma-associated plastic bronchitis with extracorporeal membrane oxygenation.

    Science.gov (United States)

    Tonan, Momoka; Hashimoto, Soshi; Kimura, Akio; Matsuyama, Hiroki; Kinose, Hiromi; Sawada, Maiko; Shime, Nobuaki; Tokuhira, Natsuko; Kato, Yuko; Sasaki, Masayuki; Tsuchiya, Kunihiko; Higaki, Satoshi; Oomae, Tadaki; Hashimoto, Satoru

    2012-04-01

    We describe a case of near-fatal asthma requiring extracorporeal membrane oxygenation (ECMO). The patient presented with severe respiratory distress, which was not responsive to conventional pharmacological therapy. The patient also failed to respond to mechanical ventilation and thus was placed on venovenous ECMO for temporary pulmonary support. A fiberoptic bronchoscopy revealed that large amounts of thick bronchial secretions had occluded the main bronchus, which suggested plastic bronchitis secondary to asthma. Aggressive airway hygiene with frequent bronchoscopies and application of biphasic cuirass ventilation for facilitation of secretion clearance were performed to improve the patient's respiratory status. The patient achieved a full recovery and suffered no neurological sequelae. This case illustrates that aggressive pulmonary hygiene with ECMO is a useful therapy for patients with asthma-associated plastic bronchitis.

  3. A liquid phase blocking ELISA for the detection of antibodies against infectious bronchitis virus

    Directory of Open Access Journals (Sweden)

    Cardoso T.C.

    1999-01-01

    Full Text Available A liquid phase blocking ELISA (LPB-ELISA was developed for the detection and measurement of antibodies against infectious bronchitis virus (IBV. The purified and nonpurified virus used as antigen, the capture and detector antibodies, and the chicken hyperimmune sera were prepared and standardized for this purpose. A total of 156 sera from vaccinated and 100 from specific pathogen-free chickens with no recorded contact with the virus were tested. The respective serum titers obtained in the serum neutralization test (SNT were compared with those obtained in the LPB-ELISA. There was a high correlation (r2 = 0.8926 between the two tests. The LPB-ELISA represents a single test suitable for the rapid detection of antibodies against bronchitis virus in chicken sera, with good sensitivity (88%, specificity (100% and agreement (95.31%.

  4. Detection and identification of infectious bronchitis virus by RT-PCR in Iran.

    Science.gov (United States)

    Homayounimehr, Alireza; Pakbin, Ahmad; Momayyez, Reza; Fatemi, Seyyedeh Mahsa Rastegar

    2016-06-01

    Infectious bronchitis virus (IBV) causes severe diseases in poultry with significant economic consequences to the poultry industry in Iran. The aim of this study was the detection and identification of IBV by reverse transcription(RT)-PCR in Iran. Ten IB virus strains were detected by testing trachea, cecal tonsil, and kidney tissues collected from broiler and layer farms in Iran. In order to detect infectious bronchitis virus, an optimized RT-PCR was used. Primers targeting the conserved region of known IBV serotypes were used in the RT-PCR assay. Primers selectively detecting Massachusetts and 793/B type IB viruses were designed to amplify the S1 gene of the virus and used in the nested PCR test. Our findings indicate the circulation of at least three genotypes of IB viruses (Massachusetts, 793/B, and variant 2) among poultry flocks.

  5. Pediatric Plastic Bronchitis: Case Report and Retrospective Comparative Analysis of Epidemiology and Pathology

    OpenAIRE

    Rebecca Kunder; Christian Kunder; Sun, Heather Y; Gerald Berry; Anna Messner; Jennifer Frankovich; Stephen Roth; John Mark

    2013-01-01

    Plastic bronchitis (PB) is a pathologic condition in which airway casts develop in the tracheobronchial tree causing airway obstruction. There is no standard treatment strategy for this uncommon condition. We report an index patient treated using an emerging multimodal strategy of directly instilled and inhaled tissue plasminogen activator (t-PA) as well as 13 other cases of PB at our institution between 2000 and 2012. The majority of cases (n=8) occurred in patients with congenital heart di...

  6. S1 gene sequence analysis of a nephropathogenic strain of avian infectious bronchitis virus in Egypt

    OpenAIRE

    Ladman Brian S; El-Kady Magdy F; Abdel-Moneim Ahmed S; Gelb Jack

    2006-01-01

    Abstract Background Infectious bronchitis is highly contagious and constitutes one of the most common and difficult poultry diseases to control. IBV is endemic in probably all countries that raise chickens. It exists as dozens of serotypes/genotypes. Only a few amino acid differences in the S1 protein of vaccine and challenge strains of IBV may result in poor protection. Tropism of IBV includes the respiratory tract tissues, proventriculus and caecal tonsils of the alimentary tract, the ovidu...

  7. Evaluation of effectiveness of hydrolyzed dextran in treatment of dust-induced bronchitis

    Energy Technology Data Exchange (ETDEWEB)

    Slinchenko, N.Z.; Filipchenko, L.L.; Volkova, V.M.

    1986-05-01

    An experimental group and a control group identical in age, work experience, dust exposure and expression of disease were treated for dust-induced bronchitis. The control group received broncholytics, anti-inflammatory preparations and physiotherapy; the experimental group received same treatment plus 200 ml of rheopolyglucin, a 10% solution of dextran (water-soluble polysaccharide of glucose), twice a week for 2 to 3 weeks. In addition to general laboratory and clinical methods of investigation, cytologic analysis of sputum before and after treatment was carried out. Results of experiment are given in 3 tables showing: Dynamics of Allergic Signs after Treatment with Rheopolyglucin, Dynamics of Content of Eosinophils in Blood after Treatment, and Cytologic Characteristics of Mucus of Patients with Dust-Induced Bronchitis. Patients treated with rheopolyglucin improved more than control group in abatement of suppurative process in lungs, strengthening of specific cellular and humoral mechanisms of immune response at level of bronchopulmonary system, increased expulsion of mineral dust from lungs and significant reduction of allergic reaction. Results quantitated in tables prove advantages of adding rheopolyglucin to traditional therapy in treatment of dust-induced bronchitis. 19 refs.

  8. Successful treatment of plastic bronchitis by selective lymphatic embolization in a Fontan patient.

    Science.gov (United States)

    Dori, Yoav; Keller, Marc S; Rychik, Jack; Itkin, Maxim

    2014-08-01

    Plastic bronchitis is a rare and often fatal complication of single-ventricle surgical palliation after total cavopulmonary connection. Although lymphatic abnormalities have been postulated to play a role in the disease process, the etiology and pathophysiology of this complication remain incompletely understood. Here we report on the etiology of plastic bronchitis in a child with total cavopulmonary connection as demonstrated by magnetic resonance (MR) lymphangiography. We also report on a new treatment of this disease. The patient underwent noncontrast T2-weighted MR lymphatic mapping and dynamic contrast MR lymphangiography with bi-inguinal intranodal contrast injection to determine the anatomy and flow pattern of lymph in his central lymphatic system. The MRI scan demonstrated the presence of a dilated right-sided peribronchial lymphatic network supplied by retrograde lymphatic flow through a large collateral lymphatic vessel originating from the thoracic duct. After careful analysis of the MRI scans we performed selective lymphatic embolization of the pathologic lymphatic network and supplying vessel. This provided resolution of plastic bronchitis for this patient. Five months after the procedure, the patient remains asymptomatic off respiratory medications.

  9. A controlled multi-centre study of herbal versus synthetic secretolytic drugs for acute bronchitis.

    Science.gov (United States)

    Ernst, E; März, R; Sieder, C

    1997-12-01

    Herbal expectorants and secretolytic drugs hold a sizeable share of the European market. Therefore it is essential to test their clinical effectiveness and safety. The aim of the present study was to compare the herbal medication Bronchipret(®) with various other pharmacotherapeutical options for acute bronchitis. The study was designed as a matched-pair comparison of 7783 patients. Clinical outcomes of bronchitis and adverse reactions were documented. The data were evaluated by comparing the treatment success of the test medication and 3 control groups using ordinal regression. The results suggest that clinical effectiveness of Bronchipret(®) was not less than with synthetic drugs. There was a tendency for better results with Bronchipret(®), particularly in the treatment of adults. Similar results were obtained with respect to adverse reactions. Particularly in the adult sub-group, these were markedly less with herbals as compared to synthetic drugs. These findings imply that a risk/benefit evaluation would favour Bronchipret(®) over synthetic drugs for acute bronchitis. Their interpretation is limited through the fact that this study could not be randomised nor blinded. The results therefore require confirmation through randomised, double-blind trials.

  10. Effective use of corticosteroids in treatment of plastic bronchitis with hemoptysis in Chinese adults

    Institute of Scientific and Technical Information of China (English)

    Gang WANG; You-juan WANG; Feng-ming LUO; Lei WANG; Li-li JIANG; Lin WANG; Bing MAO

    2006-01-01

    Aim: To investigate whether corticosteroids are effective in the treatment of plastic bronchitis with hemoptysis. Methods: A retrospective, clinical study was undertaken. Thirty two patients with only first episodes of plastic bronchitis with hemoptysis were divided into a steroid group (n=18) treated with glucocorticoids, and a non-steroid group (n=14). The supportive therapy was uniformly applied to both groups, except for glucocorticoids. Variables such as temperature and white blood cell counts were determined. Furthermore, the volume of hemoptysis and bronchial casts were evaluated in detail daily. Results: There was no difference in the demographic data and variables at baseline between both groups (all P>0.05).On days 5,6,7 and 8, the volume of hemoptysis was significantly decreased in the steroid group compared with the non-steroid group (43±15 mL vs 117±33 mL on d 5,29±12mL vs 97±23mL on d 6,18±10mL vs 80±20mL on d 7,and 13±8mL vs 66±14 mL on d 8; all P<0.05), and on d 10 after fibreoptic bronchoscopy, the cases with bronchial casts was reduced evidently in the steroid group in comparison with the non-steroid group (OR=5.69,95% CI=1.76-43.6; P=0.005). There was no significance in mechanical ventilation and mortality between both groups. Conclusion: Despite some limitations of this study, it has been demonstrated that, on the basis of common supportive therapy, corticosteroids would be effective and safe for the treatment of plastic bronchitis with hemoptysis.

  11. Diagnosis and treatment of chronic cough in China: an insight into the status quo.

    Science.gov (United States)

    Lai, Kefang; Luo, Wei; Zeng, Guangqiao; Zhong, Nanshan

    2012-07-28

    Chronic cough is a very common complaint in clinics throughout China. Clinical and basic science research on chronic cough started late, but in recent years the effort has yielded promising findings regarding the etiological diagnosis, treatment and pathogenesis. We found that inflammation in nonasthmatic eosinophilic bronchitis has some similarities to cough variant asthma but also a number of distinct differences. Recent evidence has also suggested a mechanistic link between airway neurogenic inflammation and and gastroesophageal reflux cough (GERC). Cough-related animal models have been developed, including models for esophageal reflux, nonasthmatic eosinophilic bronchitis and allergic rhinitis. Normal reference values for differential cell counts in induced sputum, cough sensitivity and esophageal 24-h pH monitoring in Chinese healthy subjects have been established. By using a modified algorithm for the etiological diagnosis of chronic cough, the causes of chronic cough have been investigated across a number of cities in China. The most common causes of chronic cough are cough variant asthma, eosinophilic bronchitis, upper airway cough symptoms, atopic cough and GERC, however, there are some regional variations. The Chinese National Guidelines on Diagnosis and Management of Chronic Cough were drafted in 2005, updated in 2009, and have been widely publicized and disseminated through many channels since their publication.

  12. Fontan patient with plastic bronchitis treated successfully using aerosolized tissue plasminogen activator: a case report and review of the literature.

    Science.gov (United States)

    Do, Thomas B; Chu, James M; Berdjis, Farhouch; Anas, Nick G

    2009-04-01

    Plastic bronchitis is an uncommon condition characterized by the production of large pale bronchial casts that obstruct the tracheobronchial tree. The cellular content, cohesiveness, and often rubber-like consistency distinguish bronchial casts from the usual mucus plugs found with such disease states as asthma. Plastic bronchitis can be found secondary to many conditions, and a simplified classification scheme organizes it into two groups: an inflammatory type consisting of casts with an eosinophilic inflammatory infiltrate and an acellular type with a predominance of fibrin distinguished by its relative lack of cellular infiltrate, its mucin predominance, and its appearance only in children with congenital cyanotic heart disease. This report describes a 5-year-old girl who experienced plastic bronchitis 3 months after a Fontan procedure for hypoplastic left heart syndrome that was treated successfully with aerosolized tissue plasminogen activator.

  13. THE USAGE OF HALOAEROSOLOTHERAPY IN THE REHABILITATIONAL TREATMENT OF CHILDREN WITH RECCURENT BRONCHITIS

    Directory of Open Access Journals (Sweden)

    LEMKO Ivan

    2015-05-01

    Full Text Available Aim. Comparative evaluation of the effectiveness of various therapeutic complexes on the basis of haloaerosoltherapy in the rehabilitational treatment of children with recurrent bronchitis on the ground of clinical and functional data and further development of recommendations for differentiated treatment. Objectives. Children (at the age of 6-10 years with recurrent bronchitis, who received treatment in conditions of artificial rock salt aerosol medium (haloaerosoltherapy. Material and Methods. 35 children with recurrent bronchitis (RB were examined. All children’s clinical data were monitored; respiratory function was evaluated using spirography. Forced inspiratory vital capacity (FIVC, forced expiratory volume for the 1-st second (FEV1, peak expiratory flow (PEF, forced expiratory flow at the point of 25% from FIVC(FEF25, forced expiratory flow at the point of 50% from FIVC (FEF50, and forced expiratory flow at the point of 75% from FIVC (FEF75 were defined. The patients were treated with the help of two therapeutic complexes (TC. 12 children were treated by the first TC which included haloaerosoltherapy (14 procedures, in well-equipped room with the initial concentration of rock salt aerosol 40 mg/m3 and the predominance of fine powder fraction (<80%. The first procedure lasted 10 minutes, the second – 20 minutes, the third and the following ones – 30 minutes. The concentration and dispersity of haloaerosol were measured with the help of special laser optical system. 23 children underwent second TC, which included 12 procedures of singlet oxygen therapy in the form of foam additionally to the haloaerosoltherapy sessions. Results. At the beginning of the treatment children had no signs of the acute phase of the disease. Though there were some symptoms which testify that the inflammatory process and functional recovery are not finished yet after the acute phase of the recurrent bronchitis. The clinical picture was confirmed by the major

  14. Identification of one peptide which inhibited infectivity of avian infectious bronchitis virus in vitro

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Purified avian infectious bronchitis virus (IBV) was used to screen a random phage display peptide library. After the fourth panning, 10 positive phages were sequenced and characterized. The phages specifically inhibited IBV infectivity in HeLa cells and blocked IBV haemagglutination. One linear peptide "GSH HRH VHS PFV" from the positive phages with the highest neutralization titer was synthesized and this peptide inhibited IBV infection in HeLa as well. The results may contribute to development of antiviral therapeutics for IBV and studying the determinants for viral and cell interaction.

  15. Role of Atypical Pathogens and the Antibiotic Prescription Pattern in Acute Bronchitis: A Multicenter Study in Korea

    OpenAIRE

    Park, Sunghoon; Oh, Kil Chan; Kim, Ki-Seong; Song, Kyu-Tae; Yoo, Kwang Ha; Shim, Yun Su; Lee, Young Ju; Lee, Myung Goo; Yun, Jang Uk; Kim, Hyun Su; Kim, Yee Hyung; Lee, Won Jun; Kim, Do Il; Cha, Hyung Gun; Lee, Jae-Myung

    2015-01-01

    The role of atypical bacteria and the effect of antibiotic treatments in acute bronchitis are still not clear. This study was conducted at 22 hospitals (17 primary care clinics and 5 university hospitals) in Korea. Outpatients (aged ≥ 18 yr) who had an acute illness with a new cough and sputum (≤ 30 days) were enrolled in 2013. Multiplex real-time polymerase chain reaction (RT-PCR) was used to detect five atypical bacteria. A total of 435 patients were diagnosed as having acute bronchitis (vs...

  16. Molecular characterization of infectious bronchitis viruses isolated from broiler chicken farms in Iran, 2014-2015.

    Science.gov (United States)

    Najafi, Hamideh; Langeroudi, Arash Ghalyanchi; Hashemzadeh, Masoud; Karimi, Vahid; Madadgar, Omid; Ghafouri, Seyed Ali; Maghsoudlo, Hossein; Farahani, Reza Khaltabadi

    2016-01-01

    Infectious bronchitis (IB) is a viral avian disease with economic importance in the world, including Iran. S1 gene sequencing has been used for molecular epidemiological studies and genotypic characterization of infectious bronchitis virus (IBV). A total of 118 IBV isolates were obtained from tissue samples from chickens with clinically suspected IB from Iranian broiler farms (eight provinces, 200 samples). The isolates were confirmed by real-time polymerase chain reaction (PCR) and characterized by sequencing the spike glycoprotein gene. The isolates formed six distinct phylogenetic groups (IS/1494/06 [Var2] like, 4/91-like, IS/720-like, QX-like, IR-1 and Mass-like) that were related to variants isolated in the region. The most frequently detected viruses were of the Var2-like (IS/1494/06-like) genotype, with an overall prevalence of 34 %. Twenty-one percent of the isolates formed a cluster together with the 4/91 IBV type, 10 % were of the QX genotype, and 8 % were of the IS/720 genotype. In addition, 4 % and 3 % of the isolates belonged to the Massachusetts and IR-1 genotype, respectively. For the first time, we have isolated and characterized IBV variants from broiler farms in different provinces of Iran. This study demonstrates a constant evolution of IBV in Iran, demonstrating the need for continuous monitoring and development of new vaccines based on indigenous viruses.

  17. [A long-term prospective observation of the course of dust-induced bronchitis in mechanical engineering workers].

    Science.gov (United States)

    Kleĭner, A I; Makotchenko, V M; Efremova, V A; Prilipskaia, N I; Martynov, P N; Ovchinnik, E N

    1993-04-01

    A study of 206 machine builders in dynamics (up to 15 years) with dust-induced bronchitis showed that the disease has a tendency to advancing within the first three years, especially in those with a combination of noxious professional factors (dust, heat, hard physical work). Negative risk factors: working conditions, preceding unspecific respiratory infections, smoking.

  18. Treatment of 301 Infantile Acute Bronchitis Patients withQingre Lifei (清热利肺) Oral Liquid

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    From December 1995 to May 1996, 4 hospitals in Beijing, Guangzhou and Chengdu had 301 patients with infantile acute bronchitis (IAB) treated with Qingre Lifei (清热利肺, QRLF) oral liquid and the results compared with that of similar cases treated with Shema (射麻, SM) oral liquid. Following is the report.

  19. Epitopes on the peplomer protein of infectious bronchitis virus strain M41 as defined by monoclonal antibodies.

    NARCIS (Netherlands)

    N.M.C. Bleumink-Pluym; A.D.M.E. Osterhaus (Albert); M.C. Horzinek; B.A.M. van der Zeijst (Ben); H.G.M. Niesters (Bert)

    1987-01-01

    textabstractSixteen monoclonal antibodies (Mcabs) were prepared against infectious bronchitis virus strain M41, all of them reacting with the peplomer protein. One of them, Mcab 13, was able to neutralize the virus and to inhibit hemagglutination. Competition binding assays allowed the definition of

  20. HOSPITAL CONTACTS FOR CHRONIC DISEASES AMONG DANISH SEAFARERS AND FISHERMEN

    DEFF Research Database (Denmark)

    Kaerlev, Linda; Dahl, Søren; Nielsen, Per Sabro

    using rates specific for age and calendar time for the entire Danish workforce as a reference. Results: The SHCRs for lung and cardiovascular diseases were high for non-officers. Among officers, the SHCR for chronic heart diseases was statistically significantly higher in the 1999 than in the 1994...... seafarers (officers and non-officers) registered by the Danish Maritime Authority (DMA) 1986-1998 and fishermen retrieved from a pension registry 1964-1998 were linked to the nationwide Occupational Hospitalisation Registry (OHR) and followed up for incident diseases from 1 January1994 and 1 January 1999...... cohort. For both time periods high SHCR values were found for bronchitis, emphysema, cancer of the lung, alcohol-related liver diseases and diabetes among non-officers, and lung cancer among officers. Among fishermen high SHCRs for bronchitis, emphysema, lung cancer and Raynaud's syndrome were found...

  1. Industrial bronchitis

    Science.gov (United States)

    ... et al, eds. Murray and Nadel's Textbook of Respiratory Medicine . 5th ed. Philadelphia, PA: Elsevier Saunders; 2010:chap 64. Tarlo SM. Occupational lung disease. In: Goldman L, Schafer AI, eds. Goldman's Cecil ...

  2. Infectious bronchitis virus and brown shell colour: Australian strains of infectious bronchitis virus affect brown eggshell colour in commercial laying hens differently.

    Science.gov (United States)

    Samiullah, Sami; Roberts, Juliet; Chousalkar, Kapil

    2016-10-01

    The aim of the current study was to assess any effect of wild and vaccine Australian infectious bronchitis virus (IBV) strains on shell colour in brown-shelled eggs. In Experiment 1, eggs were collected from day 1 to day 13 post-inoculation (p.i.) from unvaccinated laying hens challenged with IBV wild strains T and N1/88 and from a negative control group of hens. In Experiment 2, eggs were collected from 2 to 22 days p.i. from unvaccinated and vaccinated laying hens challenged with either a wild or a vaccine strain of IBV. In Experiment 1, there was a significant effect (P shell reflectivity, L* and protoporphyrin IX (PP IX) in eggshells, with and without cuticle. The mean PP IX/g of shell with and without cuticle was significantly higher on day 1 p.i. compared to day 7, after which PP IX increased with day p.i. In Experiment 2, shell reflectivity and L* increased and PP IX decreased with increased day p.i. until day 12. Shell reflectivity and L* decreased slightly after day 12 and increased again towards day 22. Shell reflectivity, L* and PP IX were not significantly different for eggshells from unvaccinated and vaccinated laying hens in the intact eggshell, but were significantly different in shells from which cuticle had been removed. In conclusion, the IBV strains reduced the intensity of brown shell colour to different extents with a lower amount of PP IX in eggshells.

  3. Clinical Treatment of Chronic Bronchitis:an Analysis of 34 Cases%34例慢性支气管炎临床治疗分析

    Institute of Scientific and Technical Information of China (English)

    赫英红

    2016-01-01

    Objective To investigate the comprehensive treatment of chronic bronchitis patients.Methods34 cases of chronic bronchitis in January 2014 to June 2015 were analyzed. The clinical treatment of cases with chronic bronchitis was analyzed.Results After treatment, 24 cases were markedly effective, 8 cases effective, 2 cases ineffective, and the total effective rate was 94.1%.Conclusion Comprehensive treatment for patients with chronic bronchitis can control condition, to prevent lung injury, and promote their recovery as soon as possible.%目的:探讨慢性支气管炎患者的综合治疗。方法对2014年1月~2015年6月收治的慢性支气管炎患者34例临床综合治疗方法进行分析。结果经治疗显效24例,有效8例,无效2例,总有效率为94.1%。结论对慢性支气管炎患者治疗时,采取合理的综合措施,可有效控制病情,避免肺功能损伤,促进其尽快康复。

  4. Association of residential dampness and mold with respiratory tract infections and bronchitis: a meta-analysis

    Energy Technology Data Exchange (ETDEWEB)

    Fisk, William J.; Eliseeva, Ekaterina A.; Mendell, Mark J.

    2010-11-15

    Dampness and mold have been shown in qualitative reviews to be associated with a variety of adverse respiratory health effects, including respiratory tract infections. Several published meta-analyses have provided quantitative summaries for some of these associations, but not for respiratory infections. Demonstrating a causal relationship between dampness-related agents, which are preventable exposures, and respiratory tract infections would suggest important new public health strategies. We report the results of quantitative meta-analyses of published studies that examined the association of dampness or mold in homes with respiratory infections and bronchitis. For primary studies meeting eligibility criteria, we transformed reported odds ratios (ORs) and confidence intervals (CIs) to the log scale. Both fixed and random effects models were applied to the log ORs and their variances. Most studies contained multiple estimated ORs. Models accounted for the correlation between multiple results within the studies analyzed. One set of analyses was performed with all eligible studies, and another set restricted to studies that controlled for age, gender, smoking, and socioeconomic status. Subgroups of studies were assessed to explore heterogeneity. Funnel plots were used to assess publication bias. The resulting summary estimates of ORs from random effects models based on all studies ranged from 1.38 to 1.50, with 95% CIs excluding the null in all cases. Use of different analysis models and restricting analyses based on control of multiple confounding variables changed findings only slightly. ORs (95% CIs) from random effects models using studies adjusting for major confounding variables were, for bronchitis, 1.45 (1.32-1.59); for respiratory infections, 1.44 (1.31-1.59); for respiratory infections excluding nonspecific upper respiratory infections, 1.50 (1.32-1.70), and for respiratory infections in children or infants, 1.48 (1.33-1.65). Little effect of publication

  5. Heparan sulfate is a selective attachment factor for the avian coronavirus infectious bronchitis virus Beaudette.

    Science.gov (United States)

    Madu, Ikenna G; Chu, Victor C; Lee, Hwajin; Regan, Andrew D; Bauman, Beverley E; Whittaker, Gary R

    2007-03-01

    The avian coronavirus infectious bronchitis virus (IBV) strain Beaudette is an embryo-adapted virus that has extended species tropism in cell culture. In order to understand the acquired tropism of the Beaudette strain, we compared the S protein sequences of several IBV strains. The Beaudette strain was found to contain a putative heparan sulfate (HS)-binding site, indicating that the Beaudette virus may use HS as a selective receptor. To ascertain the requirements of cell-surface HS for Beaudette infectivity, we assayed for infectivity in the presence of soluble heparin as a competitor and determined infectivity in mutant cell lines with no HS or glycosaminoglycan expression. Our results indicate that HS plays a role as an attachment factor for IBV, working in concert with other factors like sialic acid to mediate virus binding to cells, and may explain in part the extended tropism of IBV Beaudette.

  6. Structural view and substrate specificity of papain-like protease from avian infectious bronchitis virus.

    Science.gov (United States)

    Kong, Lingying; Shaw, Neil; Yan, Lingming; Lou, Zhiyong; Rao, Zihe

    2015-03-13

    Papain-like protease (PLpro) of coronaviruses (CoVs) carries out proteolytic maturation of non-structural proteins that play a role in replication of the virus and performs deubiquitination of host cell factors to scuttle antiviral responses. Avian infectious bronchitis virus (IBV), the causative agent of bronchitis in chicken that results in huge economic losses every year in the poultry industry globally, encodes a PLpro. The substrate specificities of this PLpro are not clearly understood. Here, we show that IBV PLpro can degrade Lys(48)- and Lys(63)-linked polyubiquitin chains to monoubiquitin but not linear polyubiquitin. To explain the substrate specificities, we have solved the crystal structure of PLpro from IBV at 2.15-Å resolution. The overall structure is reminiscent of the structure of severe acute respiratory syndrome CoV PLpro. However, unlike the severe acute respiratory syndrome CoV PLpro that lacks blocking loop (BL) 1 of deubiquitinating enzymes, the IBV PLpro has a short BL1-like loop. Access to a conserved catalytic triad consisting of Cys(101), His(264), and Asp(275) is regulated by the flexible BL2. A model of ubiquitin-bound IBV CoV PLpro brings out key differences in substrate binding sites of PLpros. In particular, P3 and P4 subsites as well as residues interacting with the β-barrel of ubiquitin are different, suggesting different catalytic efficiencies and substrate specificities. We show that IBV PLpro cleaves peptide substrates KKAG-7-amino-4-methylcoumarin and LRGG-7-amino-4-methylcoumarin with different catalytic efficiencies. These results demonstrate that substrate specificities of IBV PLpro are different from other PLpros and that IBV PLpro might target different ubiquitinated host factors to aid the propagation of the virus.

  7. Genome sequencing and characterization analysis of a Beijing isolate of chicken corona virus infectious bronchitis virus

    Institute of Scientific and Technical Information of China (English)

    JIN Weiwu; YU Jialin; LI Ning; GONG Yuanshi; SUN Qixin; CHEN Zhangliang; CHEN Chen; ZHANG Ying; ZHAO Yiqiang; FENG Jidong; CHEN Fuyong; WU Qingming; YANG Hanchun; WANG Ming

    2004-01-01

    Avian infectious bronchitis virus (AIBV) is lassified as a member of the genus coronavirus in the family coronaviridae. The enveloped virus has a positive-sense, single-stranded RNA genome of approximately 28 kilo-bases,which has a 5′ cap structure and 3′ polyadenylation tract.The complete genome sequence of infectious bronchitis virus (IBV), Beijing isolate, was determined by cloning sequencing and primer walking. The whole genome is 27733 nucleotides in length, has ten open reading frames: 5′-orfla-orflab-s-3a-3b-e-m- 6a-6b-n-3′. Alignments of the genome sequence of IBV Beijing isolate with those of two AIBV strains and one SARS coronavirus were performed respectively. The genome sequence of IBV Beijing isolate compared with that of the IBV strain LX4 (uncompleted, 19440 bp in size) was 91.2%similarity. However, the full-length genome sequence of IBV Beijing isolate was 85.2% identity to that of IBV Strain Beaudette, and was only 50.8% homology to that of SARS coronavirus. The results showed that the genome of IBV has remarkable variation. And IBV Beijing isolate is not closely related to SARS coronavirus. Phylogenetic analyses based on the whole genome sequence, S protein, M protein and N protein, also showed that AIBV Beijing isolate is lone virus in group Ⅲ and is distant from SARS coronavirus. In conclusion, this study will contribute to the studies of diagnosis and diseases control on IBV in China.

  8. S1 gene sequence analysis of a nephropathogenic strain of avian infectious bronchitis virus in Egypt

    Directory of Open Access Journals (Sweden)

    Ladman Brian S

    2006-09-01

    Full Text Available Abstract Background Infectious bronchitis is highly contagious and constitutes one of the most common and difficult poultry diseases to control. IBV is endemic in probably all countries that raise chickens. It exists as dozens of serotypes/genotypes. Only a few amino acid differences in the S1 protein of vaccine and challenge strains of IBV may result in poor protection. Tropism of IBV includes the respiratory tract tissues, proventriculus and caecal tonsils of the alimentary tract, the oviduct and the kidney. Results Infectious bronchitis virus (IBV strain closely related to Massachusetts (Mass serotype was isolated from broiler chickens suffering from severe renal and respiratory distresses. The isolate was serologically identified by Dot-ELISA and further characterized by RT-PCR then genotyped using S1 gene sequence analysis. Alignment of the S1 sequence of the isolate with 16 IBV strains revealed high homology to isolates related to Mass serotype. Inoculation with the strain reproduced the disease in experimental 1-day-old chickens and resulted in 20% mortality, severe renal and moderate respiratory distresses. Marked histopathological changes in both kidney and trachea were observed in experimentally infected chickens. A protection study using the H120 live attenuated vaccine showed low protection rate in spite of high S1 sequence homology (97%. Protection based criteria were: virus re-isolation attempts from trachea, tracheal and renal histopathology as well as IBV antigens detection by immunofluorescent antibody technique in kidney sections. Conclusion Periodical evaluation of cross-protective capabilities of IBV vaccine(s versus recently recovered field isolates should be performed to ensure optimum control of IBV.

  9. Feline aminopeptidase N is not a functional receptor for avian infectious bronchitis virus

    Directory of Open Access Journals (Sweden)

    Harbison Carole E

    2007-02-01

    Full Text Available Abstract Background Coronaviruses are an important cause of infectious diseases in humans, including severe acute respiratory syndrome (SARS, and have the continued potential for emergence from animal species. A major factor in the host range of a coronavirus is its receptor utilization on host cells. In many cases, coronavirus-receptor interactions are well understood. However, a notable exception is the receptor utilization by group 3 coronaviruses, including avian infectious bronchitis virus (IBV. Feline aminopeptidase N (fAPN serves as a functional receptor for most group 1 coronaviruses including feline infectious peritonitis virus (FIPV, canine coronavirus, transmissible gastroenteritis virus (TGEV, and human coronavirus 229E (HCoV-229E. A recent report has also suggested a role for fAPN during IBV entry (Miguel B, Pharr GT, Wang C: The role of feline aminopeptidase N as a receptor for infectious bronchitis virus. Brief review. Arch Virol 2002, 147:2047–2056. Results Here we show that, whereas both transient transfection and constitutive expression of fAPN on BHK-21 cells can rescue FIPV and TGEV infection in non-permissive BHK cells, fAPN expression does not rescue infection by the prototype IBV strain Mass41. To account for the previous suggestion that fAPN could serve as an IBV receptor, we show that feline cells can be infected with the prototype strain of IBV (Mass 41, but with low susceptibility compared to primary chick kidney cells. We also show that BHK-21 cells are slightly susceptible to certain IBV strains, including Ark99, Ark_DPI, CA99, and Iowa97 ( Conclusion We conclude that fAPN is not a functional receptor for IBV, the identity of which is currently under investigation.

  10. Chronic pancreatitis

    Science.gov (United States)

    Chronic pancreatitis - chronic; Pancreatitis - chronic - discharge; Pancreatic insufficiency - chronic; Acute pancreatitis - chronic ... alcohol abuse over many years. Repeated episodes of acute ... chronic pancreatitis. Genetics may be a factor in some cases. ...

  11. Changes in prevalence of chronic obstructive pulmonary disease and asthma in the US population and associated risk factors.

    Science.gov (United States)

    Halldin, Cara N; Doney, Brent C; Hnizdo, Eva

    2015-02-01

    Chronic lower airway diseases, including chronic obstructive pulmonary disease (COPD) and asthma, are currently the third leading cause of death in the United States. We aimed to evaluate changes in prevalence of and risk factors for COPD and asthma among the US adult population. We evaluated changes in prevalence of self-reported doctor-diagnosed COPD (i.e. chronic bronchitis and emphysema) and asthma and self-reported respiratory symptoms comparing data from the 1988-1994 and 2007-2010 National Health and Nutrition Examination Surveys. To investigate changes in the severity of each outcome over the two periods, we calculated changes in the proportions of spirometry-based airflow obstruction for each outcome. Prevalence of doctor-diagnosed chronic bronchitis and emphysema decreased significantly mainly among males, while asthma increased only among females. The self-reported disease and the respiratory symptoms were associated with increased prevalence of airflow obstruction for both periods. However, the prevalence of airflow obstruction decreased significantly in the second period among those with shortness of breath and doctor-diagnosed respiratory conditions (chronic bronchitis, emphysema, and asthma). COPD outcomes and asthma were associated with lower education, smoking, underweight and obesity, and occupational dusts and fumes exposure. Chronic lower airway diseases continue to be major public health problems. However, decreased prevalence of doctor-diagnosed chronic bronchitis and emphysema (in males) and decreased prevalence of airflow obstruction in those with respiratory symptoms and doctor-diagnosed respiratory diseases may indicate a declining trend and decrease in disease severity between the two periods. Continued focus on prevention of these diseases through public health interventions is prudent.

  12. Treatment of Cough and Dyspnea due to Acute Bronchitis by Plaster for Cough and Dyspnea-A Report of 735 Cases

    Institute of Scientific and Technical Information of China (English)

    陈振甫; 周文秀; 高举先; 孙江桥

    2002-01-01

    @@ In the light of the theory of treating the internal disease externally, an externally used plaster for treating cough and dyspnea due to acute bronchitis (Ke Chuan Yi Tie Kang 咳喘一贴康) was successfully applied to 735 cases of acute bronchitis (the treatment group), with the other 423 cases treated with routine western drugs as controls. The results showed that the cure rate in the treatment group was significantly higher than that in the control group (P<0.01); and that in the treatment group, the cure rate for the wind-cold type of acute bronchitis was significantly higher than that for the wind-heat type of acute bronchitis (P<0.01).

  13. Effectiveness of anti-inflammatory treatment versus antibiotic therapy and placebo for patients with non-complicated acute bronchitis with purulent sputum. The BAAP Study protocol

    OpenAIRE

    Fernández Yvonne; Cots Josep M; Pera Helena; Morros Rosa; Bayona Carolina; Moragas Ana; Llor Carl; Miravitlles Marc; Boada Albert

    2011-01-01

    Abstract Background Acute bronchitis is one of the most prevalent respiratory infections in primary care, and in more than 90% of the cases antibiotics are prescribed, mainly when purulent expectoration is present. However, this process is usually viral in origin and the benefits of antibiotic treatment are marginal. On the other hand, in recent years bronchitis has been considered more as an inflammatory than an infectious process. Thus, the aim of this study is to evaluate the clinical effe...

  14. Histopathological Analogies in Chronic Pulmonary Lesions between Cattle and Humans: Basis for an Alternative Animal Model

    Science.gov (United States)

    Ramírez-Romero, Rafael; Nevárez-Garza, Alicia M.; Rodríguez-Tovar, Luis E.; Wong-González, Alfredo; Ledezma-Torres, Rogelio A.; Hernández-Vidal, Gustavo

    2012-01-01

    Most of the natural cases of pneumonia in feedlot cattle are characterized by a longer clinical course due to chronic lung lesions. Microscopically, these lesions include interstitial fibroplasia, bronchitis, bronchiectasis, bronchiolitis obliterans, and epithelial metaplasia of the airways. Herein, the aim was to review, under a medical perspective, the pathologic mechanisms operating in these chronic pneumonic lesions in calves. Based on the similarities of these changes to those reported in bronchiolitis obliterans/organising pneumonia (BO/OP) and chronic obstructive pulmonary disease (COPD) in human beings, calves are proposed as an alternative animal model. PMID:22629176

  15. Histopathological Analogies in Chronic Pulmonary Lesions between Cattle and Humans: Basis for an Alternative Animal Model

    Directory of Open Access Journals (Sweden)

    Rafael Ramírez-Romero

    2012-01-01

    Full Text Available Most of the natural cases of pneumonia in feedlot cattle are characterized by a longer clinical course due to chronic lung lesions. Microscopically, these lesions include interstitial fibroplasia, bronchitis, bronchiectasis, bronchiolitis obliterans, and epithelial metaplasia of the airways. Herein, the aim was to review, under a medical perspective, the pathologic mechanisms operating in these chronic pneumonic lesions in calves. Based on the similarities of these changes to those reported in bronchiolitis obliterans/organising pneumonia (BO/OP and chronic obstructive pulmonary disease (COPD in human beings, calves are proposed as an alternative animal model.

  16. [Chronic cough and worsening dyspnea: a case of idiopathic tracheal stenosis].

    Science.gov (United States)

    Conti, Valentina; Calia, Nunzio; Pasquini, Claudio; Zardi, Silvia; Finetti, Cinzia; Stomeo, Francesco; Ravenna, Franco

    2013-04-01

    We report a case of idiopathic tracheal stenosis in a 75-year-old woman, who presented to our observation with a diagnosis of asthmatic bronchitis characterized by cough and exertional dyspnea, later complicated by the appearance of tirage. Biopsy of the lesion showed focal squamous metaplasia of the epithelium lining, multiple sclerosis and chronic inflammatory infiltration of the corium. The patient was treated with endoscopic destruction via rigid bronchoscopy, through the combined action of YAG laser and mechanical debulking.

  17. Dose-response-relation between croup syndrome/obstructive bronchitis and ambient air pollution in Baden-Wuerttemberg

    Energy Technology Data Exchange (ETDEWEB)

    Wichmann, H.E.; Beckmann, M.; Huebner, H.R.; Malin, E.M.; Rebmann, H.; Pizard-Weyrich, M.; Hippke, G.; Doeller, G.; Herrmann, S.; Horsch, F.; Filby, W.G.; Fund, N.; Gross, S.; Hanisch, B.; Kilz, E.; Seidel, A. (comps.)

    1988-04-01

    The data collection for the epidemiologic study which started in January 1986 has been completed. In Stuttgart, Tuebingen/Reutlingen/Rottenburg and Freudenstadt 188 physicians and 3 hospitals participated in the longitudinal study and more than 3000 cases of croup syndrome or obstructive bronchitis were reported. In the cross-sectional study the parents of more than 8000 children filled in a questionnaire, which corresponds to a response rate of about 90%. Of the positive virologic isolations approximately 50% were RS-viruses, 25% parainfluenza-viruses and 16% influenze-viruses. Parainfluenza viruses had their maximum during fall as croup syndrome had. In contrast RS-viruses were isolated more frequently in spring where also an increase of obstructive bronchitis was reported. During the winter of 1986 an epidemics of influenza B coincided with elevated numbers for both deseases. Statistical analysis of the data with respect to ambient air pollution is in process.

  18. Natural histories of chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Rennard, Stephen I; Vestbo, Jørgen

    2008-01-01

    Concepts relating to the natural history of chronic obstructive pulmonary disease (COPD) arise most importantly from the classic study of Fletcher and colleagues (The Natural History of Chronic Bronchitis and Emphysema, Oxford University Press, New York, 1976). This study, which evaluated working...... English men over 8 years, was used to construct a proposed life-long natural history. Although this is a classic study that has greatly advanced understanding of COPD, it has a number of limitations. Its duration is relatively short compared with the duration of COPD, so it is more cross-sectional than...... longitudinal. It was unable to distinguish among varied "natural histories." It assessed primarily the FEV(1), and the natural history of other features of COPD is largely undescribed. With advances in understanding the clinical features of COPD and with the development of evaluating new tools to assess...

  19. CLINICAL OBSERVATION ON TREATMENT OF ACUTE BRONCHITIS PRIMARILY WITH PRICKING-CUPPING ON BACK-SHU POINTS

    Institute of Scientific and Technical Information of China (English)

    XU Wei-dong; ZHANG Yong-juan; YANG Jie; CHEN Xiao-xiang; LIU Yong-xiang

    2006-01-01

    Objective: To observe the clinical effect of treatment of acute bronchitis primarily with prickingcupping method on Back-shu points. Methods: The patients of acute bronchitis were randomly divided into 2groups. In the observation group, there were 36 cases, who were treated with the integrated traditional Chinese and western medicine, primarily the pricking-cupping method on Back-shu points; while in the control group, there were 29 cases who were given the conventinal treatment of western medicine. All the 2 groups were treated for 7 days as one treating course. Results: The total effective rate of the observation group was 97.2% while that of the control group was 82.8%, so there is a significant difference between them. On the first and third days the clinical manifestations were more satisfactorily improved in the treatment group than in the control group (P < 0.01 ) and on the fifth and seventh days, the comparison showed no significant difference (P >0.05). Conclusion: The treatment of acute bronchitis by means of the integrated traditional Chinese and western medicine primarily with pricking-cupping method on Back-shu points is of marked therapeutic effect, simple manipulation, and little untoward effects, thus claiming the unique advantage.

  20. Bronchial hypersecretion, chronic airflow limitation, and peptic ulcer.

    Science.gov (United States)

    Kauffmann, F; Brille, D

    1981-11-01

    Men with and men without a history of peptic ulcers were compared using respiratory symptoms and spirographic measurements taken from data recorded in an epidemiologic study. Among the 1,049 men examined, 7% reported a history of peptic ulcer. A clear relationship appeared between bronchial hypersecretion and peptic ulcers. It persisted after adjustment for age, smoking habits, social class, and country of origin. Men with ulcers inhaled tobacco smoke more often. Ulcers, smoking, and chronic phlegm were independently related to a lower body build index. It seems that the relationship between smoking and ulcers was greater among men with chronic phlegm, and it is postulated that peptic ulcers and "chronic bronchitis" might be related to a "common secretory disorder." After adjustment for age, men with a history of peptic ulcers had, not a lower FEV1, but a higher vital capacity. A slightly lower FEV1/VC ratio cannot in such cases be considered as an index of chronic airflow limitation.

  1. Molecular Characteristics of S1 Gene of Infectious Bronchitis Virus Isolated from Chicken Proventriculus

    Institute of Scientific and Technical Information of China (English)

    CHENG Li-qin; ZHOU Ji-yong; John Dikki; SHEN Xing-yan; CHEN Ji-gang; ZHANG De-yong

    2003-01-01

    Infectious bronchitis virus was isolated from swollen proventriculi of clinically ill chicken. Thesuspected virus samples (2/97, 3/97, 1/98) were adapted in SPF chicken embryos for virus isolation andidentification. All the virus isolates were able to agglutinate chicken erythrocytes after treatment with trypsin,and interfer with the reproduction of Newcastle disease virus in chicken embryos, and have low antigenic relat-edness values with reference positive IBV. The isolates 2/97, 3/97, 1/98 RNAs extracted from the allantoicfluid of inoculated embryonated eggs were converted to cDNA by reverse transcription with 3'-primer of S1gene of (IBV). Polymerase chain reaction (PCR) was performed with two primers which span the S1 gene.Amplified product of 1.93 kb was subjected to EcoR Ⅰ and BamH Ⅰ digestion and the fragments obtainedwere the same as expected size. The PCR product was ligated to pBlueScript-SK (+) vector, and its nucleotidesequence was determined by the dideoxy-mediated chain termination method. Nucleotide sequence analysisshowed 73.6 - 99.7 % homology between the isolated IBV and the IBV strains in GenBank. The homology ofamino acid was 71.4 - 99.4 %.

  2. Molecular detection of infectious bronchitis and avian metapneumoviruses in Oman backyard poultry.

    Science.gov (United States)

    Al-Shekaili, Thunai; Baylis, Matthew; Ganapathy, Kannan

    2015-04-01

    Infectious bronchitis virus (IBV) and avian metapneumovirus (aMPV) are economically important viral pathogens infecting chickens globally. Identification of endemic IBV and aMPV strains promotes better control of both diseases and prevents production losses. Orophrayngeal swab samples were taken from 2317 birds within 243 different backyard flocks in Oman. Swabs from each flock were examined by RT-PCR using part-S1 and G gene primers for IBV and aMPV respectively. Thirty-nine chicken flocks were positive for IBV. Thirty two of these were genotyped and they were closely related to 793/B, M41, D274, IS/1494/06 and IS/885/00. 793/B-like IBV was also found in one turkey and one duck flock. Five flocks were positive for aMPV subtype B. Though no disease was witnessed at the time of sampling, identified viruses including variant IBV strains, may still pose a threat for both backyard and commercial poultry in Oman.

  3. Annexin A2 binds RNA and reduces the frameshifting efficiency of infectious bronchitis virus.

    Directory of Open Access Journals (Sweden)

    Hoyun Kwak

    Full Text Available Annexin A2 (ANXA2 is a protein implicated in diverse cellular functions, including exocytosis, DNA synthesis and cell proliferation. It was recently proposed to be involved in RNA metabolism because it was shown to associate with some cellular mRNA. Here, we identified ANXA2 as a RNA binding protein (RBP that binds IBV (Infectious Bronchitis Virus pseudoknot RNA. We first confirmed the binding of ANXA2 to IBV pseudoknot RNA by ultraviolet crosslinking and showed its binding to RNA pseudoknot with ANXA2 protein in vitro and in the cells. Since the RNA pseudoknot located in the frameshifting region of IBV was used as bait for cellular RBPs, we tested whether ANXA2 could regulate the frameshfting of IBV pseudoknot RNA by dual luciferase assay. Overexpression of ANXA2 significantly reduced the frameshifting efficiency from IBV pseudoknot RNA and knockdown of the protein strikingly increased the frameshifting efficiency. The results suggest that ANXA2 is a cellular RBP that can modulate the frameshifting efficiency of viral RNA, enabling it to act as an anti-viral cellular protein, and hinting at roles in RNA metabolism for other cellular mRNAs.

  4. Diagnostic and clinical observation on the infectious bronchitis virus strain Q1 in Italy

    Directory of Open Access Journals (Sweden)

    Anna Toffan

    2013-12-01

    Full Text Available This paper describes the diagnostic and clinical observations of an infectious bronchitis virus (IBV variant, referred to as Q1, in clinically ill chickens in Italy. This IBV variant was described for the first time in 1998 in China. In the autumn of 2011 it caused a small-scale epidemic in non-vaccinated meat chickens in farms located in Northern Italy. The disease was characterized by increased mortality, kidney lesions and proventriculitis. Histopatological observations confirmed the nephritis and described an unusual erosive/necrotic proventriculitis with infiltration of lymphocytes, plasma cells and heterophils, as well as fibroplasia in the lamina propria. Despite these findings and the isolation of the Q1 IB virus directly from proventricular tissue, further studies are necessary to confirm the role of this IBV strain in the development of proventricular lesions. Phylogenetic analysis revealed that all the IBV isolates were very similar and probably had a common origin. The IBV Q1 variant appears to be now endemic in the North of Italy and at times it is detected in vaccinated backyard and commercial broiler farms. The importance of continuous monitoring in controlling the spread of known or emerging IBV variants is underlined.

  5. Genotyping of news variants of the avian infectious bronchitis virus from Tolima department, Colombia

    Directory of Open Access Journals (Sweden)

    Analorena Cifuentes-Rincón

    2016-09-01

    Full Text Available Objective. The aim of this study was identify the different genotypes of infectious bronchitis virus (IVB present in commercial poultry farms from different localities of the Tolima Department, Colombia. Materials and methods. 105 samples of tracheal swabs of poultry of 21 farms were collected. Poultry had been vaccinated against IVB. An screen to identify positive samples and posteriorly the sequencing of the partial region of the S1 subunit and phylogenetic analysis of the isolates with the reference strains, including the vaccine currently used in the country was performed. Results. Poultry all farms had respiratory signs, but only four farms was confirmed the disease. Positive samples of the IBV (HT6, HT9, HT10 and HT11 were pathogenic for embryos 9-days-old. The HT6 sample was grouped in the same cluster that the Massachusetts strains. The HT9 and HT11 samples showed 99% similarity and were grouped genetically distant from the reference strains and other isolated. The HT10 sample showed low similarities with the isolates and reference strains, grouping alone in another cluster. Conclusions. New genotypes are circulating in the Tolima Department, where there is a risk of genetic recombination. Is believed that vaccines used were not providing cross-protection against the new genotypes.

  6. Complete genomic sequence analysis of infectious bronchitis virus Ark DPI strain and its evolution by recombination.

    Science.gov (United States)

    Ammayappan, Arun; Upadhyay, Chitra; Gelb, Jack; Vakharia, Vikram N

    2008-12-22

    An infectious bronchitis virus Arkansas DPI (Ark DPI) virulent strain was sequenced, analyzed and compared with many different IBV strains and coronaviruses. The genome of Ark DPI consists of 27,620 nucleotides, excluding poly (A) tail, and comprises ten open reading frames. Comparative sequence analysis of Ark DPI with other IBV strains shows striking similarity to the Conn, Gray, JMK, and Ark 99, which were circulating during that time period. Furthermore, comparison of the Ark genome with other coronaviruses demonstrates a close relationship to turkey coronavirus. Among non-structural genes, the 5'untranslated region (UTR), 3C-like proteinase (3CLpro) and the polymerase (RdRp) sequences are 100% identical to the Gray strain. Among structural genes, S1 has 97% identity with Ark 99; S2 has 100% identity with JMK and 96% to Conn; 3b 99%, and 3C to N is 100% identical to Conn strain. Possible recombination sites were found at the intergenic region of spike gene, 3'end of S1 and 3a gene. Independent recombination events may have occurred in the entire genome of Ark DPI, involving four different IBV strains, suggesting that genomic RNA recombination may occur in any part of the genome at number of sites. Hence, we speculate that the Ark DPI strain originated from the Conn strain, but diverged and evolved independently by point mutations and recombination between field strains.

  7. Complete genomic sequence analysis of infectious bronchitis virus Ark DPI strain and its evolution by recombination

    Directory of Open Access Journals (Sweden)

    Gelb Jack

    2008-12-01

    Full Text Available Abstract An infectious bronchitis virus Arkansas DPI (Ark DPI virulent strain was sequenced, analyzed and compared with many different IBV strains and coronaviruses. The genome of Ark DPI consists of 27,620 nucleotides, excluding poly (A tail, and comprises ten open reading frames. Comparative sequence analysis of Ark DPI with other IBV strains shows striking similarity to the Conn, Gray, JMK, and Ark 99, which were circulating during that time period. Furthermore, comparison of the Ark genome with other coronaviruses demonstrates a close relationship to turkey coronavirus. Among non-structural genes, the 5'untranslated region (UTR, 3C-like proteinase (3CLpro and the polymerase (RdRp sequences are 100% identical to the Gray strain. Among structural genes, S1 has 97% identity with Ark 99; S2 has 100% identity with JMK and 96% to Conn; 3b 99%, and 3C to N is 100% identical to Conn strain. Possible recombination sites were found at the intergenic region of spike gene, 3'end of S1 and 3a gene. Independent recombination events may have occurred in the entire genome of Ark DPI, involving four different IBV strains, suggesting that genomic RNA recombination may occur in any part of the genome at number of sites. Hence, we speculate that the Ark DPI strain originated from the Conn strain, but diverged and evolved independently by point mutations and recombination between field strains.

  8. A Patient with Bronchial Asthma in Whom Eosinophilic Bronchitis and Bronchiolitis Developed during Treatment

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    Yasutsugu Fukushima

    2010-01-01

    Full Text Available A 56-year-old woman was referred to our hospital because of dyspnea, wheezing, and a productive cough. Eight years before presentation, bronchial asthma was diagnosed and the patient received inhaled corticosteroids plus antiasthmatic agents (a long-acting inhaled p2-agonist, leukotriene modifiers, and theophylline. Chest radiography showed small diffuse nodular shadows, and a computed tomographic scan showed thickening of the bronchi and bronchioles, with diffuse centrilobular nodules in both lung fields. A blood test and microscopic examination of the bronchoalveolar fluid revealed marked eosinophilia. Transbronchial lung biopsy and transbronchial biopsy showed eosinophilic bronchitis and bronchiolitis. After treatment with oral prednisolone (40 mg daily and inhaled corticosteroids, the symptoms, blood eosinophilia, and radiographic findings improved. Recently, several similar cases of eosinophilic bronchiolitis have been reported. Studies of further cases and elucidation of the pathophysiology of eosinophilic bronchiolitis are necessary to establish a concept for this disease and to determine whether it should be classified as a subtype of bronchial asthma or as a distinct entity.

  9. S1 gene-based phylogeny of infectious bronchitis virus: An attempt to harmonize virus classification.

    Science.gov (United States)

    Valastro, Viviana; Holmes, Edward C; Britton, Paul; Fusaro, Alice; Jackwood, Mark W; Cattoli, Giovanni; Monne, Isabella

    2016-04-01

    Infectious bronchitis virus (IBV) is the causative agent of a highly contagious disease that results in severe economic losses to the global poultry industry. The virus exists in a wide variety of genetically distinct viral types, and both phylogenetic analysis and measures of pairwise similarity among nucleotide or amino acid sequences have been used to classify IBV strains. However, there is currently no consensus on the method by which IBV sequences should be compared, and heterogeneous genetic group designations that are inconsistent with phylogenetic history have been adopted, leading to the confusing coexistence of multiple genotyping schemes. Herein, we propose a simple and repeatable phylogeny-based classification system combined with an unambiguous and rationale lineage nomenclature for the assignment of IBV strains. By using complete nucleotide sequences of the S1 gene we determined the phylogenetic structure of IBV, which in turn allowed us to define 6 genotypes that together comprise 32 distinct viral lineages and a number of inter-lineage recombinants. Because of extensive rate variation among IBVs, we suggest that the inference of phylogenetic relationships alone represents a more appropriate criterion for sequence classification than pairwise sequence comparisons. The adoption of an internationally accepted viral nomenclature is crucial for future studies of IBV epidemiology and evolution, and the classification scheme presented here can be updated and revised novel S1 sequences should become available.

  10. Infectious bronchitis viruses with naturally occurring genomic rearrangement and gene deletion.

    Science.gov (United States)

    Hewson, Kylie A; Ignjatovic, Jagoda; Browning, Glenn F; Devlin, Joanne M; Noormohammadi, Amir H

    2011-02-01

    Infectious bronchitis viruses (IBVs) are group III coronaviruses that infect poultry worldwide. Genetic variations, including whole-gene deletions, are key to IBV evolution. Australian subgroup 2 IBVs contain sequence insertions and multiple gene deletions that have resulted in a substantial genomic divergence from international IBVs. The genomic variations present in Australian IBVs were investigated and compared to those of another group III coronavirus, turkey coronavirus (TCoV). Open reading frames (ORFs) found throughout the genome of Australian IBVs were analogous in sequence and position to TCoV ORFs, except for ORF 4b, which appeared to be translocated to a different position in the subgroup 2 strains. Subgroup 2 strains were previously reported to lack genes 3a, 3b and 5a, with some also lacking 5b. Of these, however, genes 3b and 5b were found to be present but contained various mutations that may affect transcription. In this study, it was found that subgroup 2 IBVs have undergone a more substantial genomic rearrangements than previously thought.

  11. Progress and Challenges toward the Development of Vaccines against Avian Infectious Bronchitis

    Directory of Open Access Journals (Sweden)

    Faruku Bande

    2015-01-01

    Full Text Available Avian infectious bronchitis (IB is a widely distributed poultry disease that has huge economic impact on poultry industry. The continuous emergence of new IBV genotypes and lack of cross protection among different IBV genotypes have been an important challenge. Although live attenuated IB vaccines remarkably induce potent immune response, the potential risk of reversion to virulence, neutralization by the maternal antibodies, and recombination and mutation events are important concern on their usage. On the other hand, inactivated vaccines induce a weaker immune response and may require multiple dosing and/or the use of adjuvants that probably have potential safety risks and increased economic burdens. Consequently, alternative IB vaccines are widely sought. Recent advances in recombinant DNA technology have resulted in experimental IB vaccines that show promise in antibody and T-cells responses, comparable to live attenuated vaccines. Recombinant DNA vaccines have also been enhanced to target multiple serotypes and their efficacy has been improved using delivery vectors, nanoadjuvants, and in ovo vaccination approaches. Although most recombinant IB DNA vaccines are yet to be licensed, it is expected that these types of vaccines may hold sway as future vaccines for inducing a cross protection against multiple IBV serotypes.

  12. Transient dominant selection for the modification and generation of recombinant infectious bronchitis coronaviruses.

    Science.gov (United States)

    Keep, Sarah M; Bickerton, Erica; Britton, Paul

    2015-01-01

    We have developed a reverse genetics system for the avian coronavirus infectious bronchitis virus (IBV) in which a full-length cDNA corresponding to the IBV genome is inserted into the vaccinia virus genome under the control of a T7 promoter sequence. Vaccinia virus as a vector for the full-length IBV cDNA has the advantage that modifications can be introduced into the IBV cDNA using homologous recombination, a method frequently used to insert and delete sequences from the vaccinia virus genome. Here, we describe the use of transient dominant selection as a method for introducing modifications into the IBV cDNA; this has been successfully used for the substitution of specific nucleotides, deletion of genomic regions, and the exchange of complete genes. Infectious recombinant IBVs are generated in situ following the transfection of vaccinia virus DNA, containing the modified IBV cDNA, into cells infected with a recombinant fowlpox virus expressing T7 DNA-dependent RNA polymerase.

  13. Cefditoren versus levofloxacin in patients with exacerbations of chronic bronchitis: serum inflammatory biomarkers, clinical efficacy, and microbiological eradication

    OpenAIRE

    Blasi F; Tarsia P; Mantero M; Morlacchi LC; Piffer F

    2013-01-01

    Francesco Blasi, Paolo Tarsia, Marco Mantero, Letizia C Morlacchi, Federico PifferDepartment of Pathophysiology and Transplantation, University of Milan, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Milan, ItalyBackground: The aim of this open-label, randomized, parallel-group pilot study was to evaluate the efficacy of cefditoren pivoxil and levofloxacin in terms of speed of reduction in inflammatory parameters, clinical recovery, and microbiological eradication.Metho...

  14. Clinical effectiveness and safety of gemifloxacin versus cefpodoxime in acute exacerbation of chronic bronchitis: A randomized, controlled trial

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    S Chatterjee

    2011-01-01

    Conclusion : The results of this randomized, single-blind trial demonstrated that a 7-day course of gemifloxacin is therapeutically comparable to cefpodoxime in terms of both clinical effectiveness and safety for the treatment of type II Anthonisen category AECB patients.

  15. What is chronic cough in children?

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    Iulia eIOAN

    2014-08-01

    Full Text Available The cough reflex is modulated throughout growth and development. Cough – but not expiration reflex – appears to be absent at birth, but increases with maturation. Thus, acute cough is the most frequent respiratory symptom during the first few years of life. Later on, the pubertal development seems to play a significant role in changing of the cough threshold during childhood and adolescence resulting in sex-related differences in cough reflex sensitivity in adulthood. Asthma is the major cause of chronic cough in children. Prolonged acute cough is usually related to the long-lasting effects of a previous viral airway infection or to the particular entity called protracted bacterial bronchitis. Cough pointers and type may orient towards specific aetiologies, such as barking cough in croup or tracheomalacia, paroxystic whooping cough in Pertussis. Cough is productive in protracted bacterial bronchitis, sinusitis or bronchiectasis. Cough is usually associated with wheeze or dyspnea on exertion in asthma; however, it may be the sole symptom in cough variant asthma. Thus, paediatric cough has particularities differentiating it from adult cough, so the approach and management should be developmentally specific.

  16. Development and immunogenicity of recombinant GapA(+) Mycoplasma gallisepticum vaccine strain ts-11 expressing infectious bronchitis virus-S1 glycoprotein and chicken interleukin-6.

    Science.gov (United States)

    Shil, Pollob K; Kanci, Anna; Browning, Glenn F; Markham, Philip F

    2011-04-12

    Mycoplasma gallisepticum (MG) is a major pathogen of poultry that causes chronic respiratory disease in chickens and infectious sinusitis in turkeys. A live attenuated vaccine, ts-11, has been used for the control of MG in several countries. The efficacy of this vaccine is highly dose dependent and the flock antibody response is weak. To improve the functionality of the vaccine and investigate its potential as a delivery vector for foreign antigens and immunomodulatory proteins, we developed a derivative of ts-11 expressing infectious bronchitis virus-S1 glycoprotein (IBV-S1) and releasing chicken interleukin-6 into the extracellular milieu (MG ts-11 C3 (+CS)) using a transposon-based delivery vector. Following administration of MG ts-11 C3 (+CS) to chickens by eye-drop, an antibody response to MG and IBV-S1, as determined by the rapid serum agglutination test (RSA) and Western blotting, respectively, could be detected. Birds inoculated with the recombinant vaccine had significantly enhanced weight gain and were partially protected against damage by pathogenic IBV. These results indicate that the ChIL-6 released by MG ts-11 C3 (+CS) may have had a non-specific effect on growth rate. They also suggest that ts-11 is a promising vaccine vector, capable of delivering heterologous protective antigens, and may also provide non-specific benefits when engineered to express immunomodulatory proteins. With some improvements in the expression system, it could be used to induce a targeted immune response against specific mucosal pathogens, and co-expression of several antigens would allow development of a novel multivalent vaccine.

  17. Bronquitis infecciosa aviar: diagnóstico y control -Avian infectious bronchitis: diagnosis and control

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    Acevedo Beiras, Ana María

    2010-03-01

    Full Text Available ResumenLa bronquitis infecciosa aviar (BIA es una enfermedad que ocasiona unimpacto socio-económico severo en la industria avícola mundial. Es unaenfermedad respiratoria aguda, altamente contagiosa, caracterizadaprimariamente por signos respiratorios en los pollos en crecimiento. En las ponedoras, la sintomatología respiratoria es menor pero provoca una disminución marcada en la producción y calidad del huevo. El agente etiológico de esta enfermedad es el virus de la bronquitis infecciosa aviar, un Coronavirus del grupo 3 de la familia Coronaviridae, orden Nidovirales. El virus se replica en los tejidos del tracto respiratorio y en muchos tejidos a lo largo del tracto alimentario. Este virus puede infectar otras especies de aves además de los pollos. Los signos clínicos característicos son tos, estornudos, estertores traqueales, ojos acuosos, letargo y en los pollos, especialmente los jóvenes, se presentan descargas nasales. Estos signos son indicativos pero no tienen por sí solo valor diagnóstico y la confirmación requiere el aislamiento o la demostración directa de la presencia del virus aunque la serología puede ser útil en algunas circunstancias. El diagnóstico de laboratorio requiere el aislamiento viral y su identificación. Se emplean las técnicas de reacción en cadena de la polimerasa (RT-PCR, inhibición de la hemaglutinación (HI y ensayos inmunoenzimáticos (ELISA, así como la microscopía electrónica, anticuerpos monoclonales, virus neutralización (VN, inmunohistoquímica,ensayos de inmunofluorescencia y de inmunización desafío en pollos. Son ampliamente usadas vacunas vivas e inactivadas en el control de laenfermedad.SummaryAvian infectious bronchitis (BIA is a disease that provokes a severe socioeconomic impact in poultry world industry. It is a breathing sharp disease, highly contagious, characterized primarily for breathing signs in chickens in growth. In the egg-laying, the breathing sintomatology is

  18. Severe acute respiratory syndrome vaccine development: experiences of vaccination against avian infectious bronchitis coronavirus.

    Science.gov (United States)

    Cavanagh, Dave

    2003-12-01

    Vaccines against infectious bronchitis of chickens (Gallus gallus domesticus) have arguably been the most successful, and certainly the most widely used, of vaccines for diseases caused by coronaviruses, the others being against bovine, canine, feline and porcine coronaviruses. Infectious bronchitis virus (IBV), together with the genetically related coronaviruses of turkey (Meleagris gallopovo) and ring-necked pheasant (Phasianus colchicus), is a group 3 coronavirus, severe acute respiratory syndrome (SARS) coronavirus being tentatively in group 4, the other known mammalian coronaviruses being in groups 1 and 2. IBV replicates not only in respiratory tissues (including the nose, trachea, lungs and airsacs, causing respiratory disease), but also in the kidney (associated with minor or major nephritis), oviduct, and in many parts of the alimentary tract--the oesophagus, proventriculus, duodenum, jejunum, bursa of Fabricius, caecal tonsils (near the distal end of the tract), rectum and cloaca (the common opening for release of eggs and faeces), usually without clinical effects. The virus can persist, being re-excreted at the onset of egg laying (4 to 5 months of age), believed to be a consequence of the stress of coming into lay. Genetic lines of chickens differ in the extent to which IBV causes mortality in chicks, and in respect of clearance of the virus after the acute phase. Live attenuated (by passage in chicken embryonated eggs) IBV strains were introduced as vaccines in the 1950s, followed a couple of decades later by inactivated vaccines for boosting protection in egg-laying birds. Live vaccines are usually applied to meat-type chickens at 1 day of age. In experimental situations this can result in sterile immunity when challenged by virulent homologous virus. Although 100% of chickens may be protected (against clinical signs and loss of ciliary activity in trachea), sometimes 10% of vaccinated chicks do not respond with a protective immune response

  19. Persistent and Recurrent Bacterial Bronchitis—A Paradigm Shift in Our Understanding of Chronic Respiratory Disease

    Science.gov (United States)

    Ishak, Alya; Everard, Mark L.

    2017-01-01

    The recent recognition that the conducting airways are not “sterile” and that they have their own dynamic microbiome, together with the rapid advances in our understanding of microbial biofilms and their roles in the causation of respiratory diseases (such as chronic bronchitis, sinusitis, and chronic otitis media), permit us to update the “vicious circle” hypothesis of the causation of bronchiectasis. This proposes that chronic inflammation driven by persistent bacterial bronchitis (PBB) causes damage to both the epithelium, resulting in impaired mucociliary clearance, and to the airway wall, which eventually manifests as bronchiectasis. The link between a “chronic bronchitis” and a persistence of bacterial pathogens, such as non-typable Haemophilus influenzae, was first made more than 100 years ago, and its probable role in the causation of bronchiectasis was proposed soon afterward. The recognition that the “usual suspects” are adept at forming biofilms and hence are able to persist and dominate the normal dynamically changing “healthy microbiome” of the conducting airways provides an explanation for the chronic colonization of the bronchi and for the associated chronic neutrophil-dominated inflammation characteristic of a PBB. Understanding the complex interaction between the host and the microbial communities of the conducting airways in health and disease will be a key component in optimizing pulmonary health in the future. PMID:28261574

  20. PREPARATION AND EVALUATION OF VITAMIN E ADJUVANTED OIL EMULSIFIED INFECTIOUS BRONCHITIS EXPERIMENTAL VACCINE

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    S. ALI, M. ARSHAD, M. SIDDIQUE AND M. ASHRAF

    2007-10-01

    Full Text Available The present study was conducted to prepare oil emulsified (OE infectious bronchitis (IB experimental vaccines. The vaccines were prepared using the vaccinal strain H-120 Infectious Bonchitis virus (IBV. The virus was cultivated in 9-day old embryonated eggs via allantoic cavity route. Allantoic-amniotic fluid (AAF was collected and inactivated with formalin @ 0.12%. Water in oil emulsion was prepared by adding one part of AAF to four parts of mineral oil containing water phase (Tween 80 and oil phase (Span 80 surfactants. Hydrophile lypohile balance (HLB of the emulsion was maintained at 7.0. Two oil emulsified experimental vaccines were prepared. Vaccine-I was prepared without vitamin E and Vaccine-II with vitamin E (300 mg/ml. A total of 120 day-old broiler breeder chickens were divided into 4 groups, A, B, C, and D, each having 30 birds. At the age of 21 days, experimental Vaccine-I, experimental vaccine-II and commercial IB killed (H-120 vaccine were inoculated @ 0.5 ml in the birds of groups A, B and C, respectively. Group D was maintained as nonvaccinated control. Efficacy of the vaccines was evaluated on the basis of humoral immune response (haemagglutination inhibition antibody titres against IB in the four groups. The seven weeks cumulative mean antibody titres (CMT of each group were calculated. The highest CMT was observed in group B (130, followed by group C (69, group A (58 and group D (17. Statistical analysis showed that haemagglutination inhibition (HI antibody titres in group B (vaccine- II were significantly higher than those of groups A, B and C (P< 0.05.

  1. Preparation and Competative Immune Responce Evaluation of Infectious Bronchitis (H-120 + Newcastle Disease (La-Sota Live Bivalent Vaccine

    Directory of Open Access Journals (Sweden)

    Masoudi, Sh

    2016-03-01

    Full Text Available Newcastle disease (ND and Infectious Bronchitis (IB are highly contagious, acute and common poultry viral diseases. Control of these two important diseases of poultry industry was based on biosecurity and vaccination program. There is discussion about viral interference between these two viruses when combined. The aim of this research was to assess the effectiveness of a Razi live bivalent vaccine containing LaSota strain of Newcastle Disease Virus (NDV and H-120 strain of Infectious Bronchitis Virus (IBV. The bivalent vaccine was formulated based on EID50 titer of viruses. The immunogenicity of the vaccine was compared with commercial and monovalent Razi live IB (H-120 and ND (La Sota vaccines in Specific pathogen free (SPF and commercial chickens. The vaccination response was evaluated by haemagglutination inhibition (HI, serum neutralization and enzyme linked immunosorbent assay (ELISA antibody titers. SPF chickens that had received one dose of the Razi bivalent vaccine, has antibody titer (HI of Newcastle 5.87 based on Log2 and the serum neutralization index of Infectious bronchitis 6.5. Geometric mean antibody titers (GMTs of HI were 3.20 and 3.30 for Razi bivalent vaccine and commercial one respectively. Serum IBV ELISA antibodies GMTs were 3569 and 1992 and 320 for Razi bivalent vaccine and commercial one and control group respectively. Therefore antibody titers against NDV and IBV in chickens that received Razi vaccine were similar to those that were given monovalent and commercial vaccine. Our results show that the combined ND+IB vaccine has the ability to induce a high level of immune response in vaccinated chickens and no interference was seen between Razi and commercial one.

  2. Chronic obstructive pulmonary disease in China: a tale of two people

    Institute of Scientific and Technical Information of China (English)

    SUN Yong-chang

    2010-01-01

    @@ The term chronic obstructive pulmonary disease (COPD) has been well known and the disease extensively studied for more than a decade in China, but only recently has great progress been made in the epidemiology and management of this highly prevalent disease in this country. Historically, beginning in the early 1960s, long before the definition of COPD was widely accepted, a great number of studies that included traditional Chinese medicine had been performed on chronic bronchitis, emphysema, and related respiratory failure and cor pulmonale.

  3. A Mitochondrial Perspective of Chronic Obstructive Pulmonary Disease Pathogenesis

    Science.gov (United States)

    Shadel, Gerald S.

    2016-01-01

    Chronic obstructive pulmonary disease (COPD) encompasses several clinical syndromes, most notably emphysema and chronic bronchitis. Most of the current treatments fail to attenuate severity and progression of the disease, thereby requiring better mechanistic understandings of pathogenesis to develop disease-modifying therapeutics. A number of theories on COPD pathogenesis have been promulgated wherein an increase in protease burden from chronic inflammation, exaggerated production of reactive oxygen species and the resulting oxidant injury, or superfluous cell death responses caused by enhanced cellular injury/damage were proposed as the culprit. These hypotheses are not mutually exclusive and together likely represent the multifaceted biological processes involved in COPD pathogenesis. Recent studies demonstrate that mitochondria are involved in innate immune signaling that plays important roles in cigarette smoke-induced inflammasome activation, pulmonary inflammation and tissue remodeling responses. These responses are reviewed herein and synthesized into a view of COPD pathogenesis whereby mitochondria play a central role.

  4. Add-on treatment with nebulized hypertonic saline in a child with plastic bronchitis after the Glenn procedure.

    Science.gov (United States)

    Lis, Grzegorz; Cichocka-Jarosz, Ewa; Jedynak-Wasowicz, Urszula; Glowacka, Edyta

    2014-01-01

    Plastic bronchitis (PB), although a rare cause of airway obstruction, has mortality rates up to 50% in children after Fontan-type cardiac surgery. We present the case of an 18-month-old female patient with PB following pneumonia. At 6 months of age, the patient underwent the Glenn procedure due to functionally univentricular heart. Fiberoptic bronchoscopy revealed complete blockage of the left bronchus by mucoid casts. Pharmacotherapy consisted of glucocorticosteroids, azithromycin, and enalapril maleate. The child also received nebulized 3% NaCl solution, which proved to be beneficial. In children submitted to Fontan-type procedures, physicians must be alert for PB, which can be triggered by respiratory tract infection.

  5. Bridging Lung Development with Chronic Obstructive Pulmonary Disease. Relevance of Developmental Pathways in Chronic Obstructive Pulmonary Disease Pathogenesis.

    Science.gov (United States)

    Boucherat, Olivier; Morissette, Mathieu C; Provencher, Steeve; Bonnet, Sébastien; Maltais, François

    2016-02-15

    Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation. This generic term encompasses emphysema and chronic bronchitis, two common conditions, each having distinct but also overlapping features. Recent epidemiological and experimental studies have challenged the traditional view that COPD is exclusively an adult disease occurring after years of inhalational insults to the lungs, pinpointing abnormalities or disruption of the pathways that control lung development as an important susceptibility factor for adult COPD. In addition, there is growing evidence that emphysema is not solely a destructive process because it is also characterized by a failure in cell and molecular maintenance programs necessary for proper lung development. This leads to the concept that tissue regeneration required stimulation of signaling pathways that normally operate during development. We undertook a review of the literature to outline the contribution of developmental insults and genes in the occurrence and pathogenesis of COPD, respectively.

  6. Neutralization Analysis of a Chicken Single-Chain Variable Fragment Derived from an Immune Antibody Library Against Infectious Bronchitis Virus.

    Science.gov (United States)

    Lin, Yuan; Li, Benqiang; Ye, Jiaxin; Wang, Man; Wang, Jianhua; Zhang, Ying; Zhu, Jianguo

    2015-09-01

    Avian infectious bronchitis virus (IBV), which is prevalent in many countries causing severe economic loss to the poultry industry, causes infectious bronchitis (IB) in birds. Recombinant single-chain variable fragments (scFvs) have been proven to effectively inhibit many viruses, both in vitro and in vivo, and they could be a potential diagnostic and therapeutic reagent to control IB. In this study, six anti-IBV chicken scFvs, ZL.10, ZL.64, ZL.78, ZL.80, ZL.138, and ZL.256, were obtained by screening random clones from an immune antibody library. An analysis of nucleotide sequences revealed that they represented distinctive genetic sequences and greatly varied in complementarity-determining region three of the heavy chain. Neutralization tests showed that ZL.10, which bound the S1 protein in western blots, inhibited the formation of syncytia in Vero cells 48 h post IBV infection and decreased the transcriptional level of nucleoprotein mRNA to 17.2%, while the other five scFvs, including ZL.78 and ZL.256, that bound the N protein did not. In conclusion, the results suggested that specific and neutralizing chicken scFvs against IBV, which can be safe and economical antibody reagents, can be produced in vitro through prokaryotic expression.

  7. Effect of associated vaccines on the interference between Newcastle disease virus and infectious bronchitis virus in broilers

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    WM Cardoso

    2005-09-01

    Full Text Available The phenomenon of viral interference between live vaccines against Newcastle Disease and infectious bronchitis has been reported since the 50's and many researchers have reported its prejudicial effects on avian immunization. Therefore, this study evaluated the effect of associated vaccines on the interference between Newcastle disease virus (NDV and infectious bronchitis virus (IBV in broilers. There were 400 broiler chicks divided into five groups. The groups were submitted to mono or polyvalent vaccinations against IBV and NDV, except for the non-vaccinated control group (CG. Sera were collected at 35 and 45 days of age and submitted to serologic tests to assess antibody levels. It was observed the occurrence of interference in the immune response against NDV by the use of associated vaccines to NDV and IBV; however, the group that was immunized with commercial combined vaccines (IBV+NDV presented antibody titers to NDV similar to the group that was given only vaccine against NDV. We concluded based on these preliminary studies that the interference of IBV on the immune response against NDV depends also whether the association between the two vaccines is done just before vaccination or in the manufacturing laboratory.

  8. Increasing awareness of recognition of chronic obstructive pulmonary disease

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ The medical community should, by now, be well aware of the importance of chronic obstructive pulmonary disease (COPD), an increasingly common condition with high morbidity and mortality. In modern terms, COPD has come to signify concurrent chronic bronchitis, asthmatic bronchitis and emphysema. Cigarette smoking has long been recognized as the predominant aetiological agent. Arterial hypoxaemia, a frequent complication of COPD, can lead to pulmonary hypertension and cor pulmonale. COPD affects over 5% of the adult population and is the only major cause of death whose morbidity and mortality are increasing in several countries.1 In China, it is difficult to quantify how many people are affected with COPD. However, a recent epidemiological survey indicated that COPD prevalence was 8.2% in China. COPD prevalence in men was significantly higher than in women (12.4% cf 5.1%). The prevalence in rural areas was higher than that in urban areas (8.8% cf 7.8%). Of patients with COPD, 61.5% were smokers. The report also stated that COPD is the major cause of death in rural areas in China and the fourth leading cause of death in urban areas, rising to the third leading cause of death by 2020.2 The prevalence of the disease increases with age with highest rates seen in people over the age of 70 years. COPD is the only major cause of mortality with a rising incidence and prevalence worldwide, rendering it an increasingly worrisome

  9. Reciprocal Antibody and Complement Responses of Two Chicken Breeds to Vaccine Strains of Newcastle Disease Virus, Infectious Bursal Disease Virus and Infectious Bronchitis Virus

    NARCIS (Netherlands)

    Baelmans, R.; Parmentier, H.K.; Dorny, P.; Demey, F.; Berkvens, D.

    2006-01-01

    Serum antibody responses and haemolytic complement activity were evaluated in White Leghorn (WLH) and Rhode Island Red (RIR) chickens that were vaccinated with live-attenuated vaccines of Newcastle disease virus, or infectious bronchitis virus, or infectious bursal disease virus by means of ocular c

  10. High-resolution CT in patients with chronic airflow obstruction: correlation with clinical diagnosis and pulmonary function test

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Ki Taek; Kang, Eun Young; Rhee, Ji Yong; Kim, Jin Hyung; Choi, Jung Ah; Cho, Jae Yoen; Oh, Yu Whan; Suh, Won Hyuck [College of Medicine, Korea University, Seoul (Korea, Republic of)

    2000-06-01

    To determine the utility of HRCT in the diagnosis of chronic airflow obstruction and to correlate the morphologic abnormalities revealed by this modality with functional impairment in patients with chronic airflow obstruction. This study involved 80 patients with chronic airflow obstruction who underwent HRCT and a pulmonary function test. Final clinical diagnosis in these patients was determined by a chest physician on the basis of clinical features, bronchoscopy, pulmonary function test, and HRCT. In order to diagnose and determine the extent of areas of decreased attenuation revealed by HRCT (the CT score), the findings of HRCT were retrospectively reviewed by two radiologists, who reached a consensus. Clinical and HRCT diagnoses were then compared, and the rate of agreement between them was calculated. The relationship between the extent of areas of decreased attenuation revealed by HRCT and by FEV1/FVC was evaluated using Correl's account and Student's unpaired t-test. The agreement rate between clinical and HRCT diagnoses was 77.5% (62/80). The rates for bronchiectasis (88.9%, 24/27), emphysema (93.9%, 31/33), and bronchiolitis obliterans (100%, 6/6) were considerably higher than those for chronic bronchitis and bronchial asthma. The correlation rate between CT score and FEV1/FVC was significant in bronchiectasis (p less than 0.05; r: -0.76) and bronchiolitis obliterans (p less than 0.01; r: -0.66), but not in cases involving emphysema, bronchial asthma, or chronic bronchitis (p greater than 0.05). HRCT is valuable in the diagnosis and prediction of physiologic impairment in patients with bronchiectasis and bronchiolitis obliterans, but has limited value in those with emphysema, chronic bronchitis or asthma. (author)

  11. Chronic myelogenous leukemia (CML)

    Science.gov (United States)

    CML; Chronic myeloid leukemia; Chronic granulocytic leukemia; Leukemia - chronic granulocytic ... Chronic myelogenous leukemia is grouped into phases: Chronic Accelerated Blast crisis The chronic phase can last for ...

  12. The Nature and Causes of Chronic Obstructive Pulmonary Disease: A Historical Perspective

    Directory of Open Access Journals (Sweden)

    C Peter W Warren

    2009-01-01

    Full Text Available Chronic obstructive pulmonary disease (COPD is the currently favoured name for the diseases formerly known as emphysema and bronchitis. COPD has been recognized for more than 200 years. Its cardinal symptoms are cough, phlegm and dyspnea, and its pathology is characterized by enlarged airspaces and obstructed airways. In the 19th century, the diagnosis of COPD depended on its symptoms and signs of a hyperinflated chest, and reduced expiratory breath sounds. The airflow obstruction evident on spirometry was identified in that century, but did not enter into clinical practice. Bronchitis, and the mechanical forces required to overcome its obstruction, was believed to be responsible for emphysema, although the inflammation present was recognized. The causes of bronchitis, and hence emphysema, included atmospheric and domestic air pollution, as well as dusty occupations. Cigarette smoking only became recognized as the dominant cause in the 20th century. The lessons learned of the risks for COPD in 19th-century Britain are very pertinent to the world today.

  13. Infectious bronchitis in Brazilian chickens: current data and observations of field service personnel

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    EN Silva

    2010-09-01

    Full Text Available The infectious bronchitis virus (IBV was detected for the first time in Brazil by Hipólito in 1957 in chickens sold life in the municipal market of Belo Horizonte, MG, when commercial poultry production was just starting in that country. The Massachusetts (Mass serotype was identified. However, the clinical disease was only observed in 1975, when poultry production was intensely growing. The extensive outbreak produced the classical condition in layers and breeders, affecting egg production and quality, whereas broilers presented respiratory and "nephritis-nephrosis" signs. The disease rapidly spread to all poultry-producing regions in the country, and in 1979, both the imports and the manufacturing of live vaccines against IB strains Mass, H120 and H52, were licensed. In 1980, inactivated vaccines were introduced. Molecular techniques, particularly PCR, started to bed in the identification of IBV. A retrospective analysis showed that, up to 1989, the main IBV strain circulating in Brazil was Mass. However, other studies shows the presence of a wide diversity of IBV strains in Brazil since the first strains were isolated, even before vaccination was introduced. Most researchers agree that the incidence of IBV different from Mass has increased, including of exclusively Brazilian genotypes, different from those described in other countries. Indeed, during the last few years, the number of genotypical variants has been much higher than that of the classical Mass serotype. Clinically, in addition of the classic presentations, atypical forms such as testicular atrophy and stones in the epidydimis associated to low fertility have been described. Serological techniques started to be used in vaccination monitoring and as a diagnostic tool. Serological response standards were developed, and have shown to be very useful to determine the expected profile in vaccination programs and when clinical disease is suspected. However, the immuno-enzymatic test

  14. Number 2: Chronic Obstructive Pulmonary Disease: The Importance of Exercise

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    Norman L Jones

    2000-01-01

    Full Text Available Patients with chronic obstructive pulmonary disease (COPD - chronic bronchitis, emphysema, asthma are often limited in their capacity to exercise, mainly because they experience shortness of breath or muscle fatigue. The reasons for shortness of breath are dealt with in another patient page (Can Respir J 2000;7(1:35-36, and include narrowing of the airways, poor lung function leading to falls in the amount of oxygen carried in the blood and weak muscles for breathing. Easy fatiguability may be because of muscle weakness or changes in muscle function, related to inactivity and ageing. Other less common factors include heart problems associated with COPD, and other coexisting health problems, such as anemia and arthritis.

  15. Adjuvant Activity of Sargassum pallidum Polysaccharides against Combined Newcastle Disease, Infectious Bronchitis and Avian Influenza Inactivated Vaccines

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    Li-Jie Li

    2012-11-01

    Full Text Available This study evaluates the effects of Sargassum pallidum polysaccharides (SPP on the immune responses in a chicken model. The adjuvanticity of Sargassum pallidum polysaccharides in Newcastle disease (ND, infectious bronchitis (IB and avian influenza (AI was investigated by examining the antibody titers and lymphocyte proliferation following immunization in chickens. The chickens were administrated combined ND, IB and AI inactivated vaccines containing SPP at 10, 30 and 50 mg/mL, using an oil adjuvant vaccine as a control. The ND, IB and AI antibody titers and the lymphocyte proliferation were enhanced at 30 mg/mL SPP. In conclusion, an appropriate dose of SPP may be a safe and efficacious immune stimulator candidate that is suitable for vaccines to produce early and persistent prophylaxis.

  16. Elisa evaluation of the levels of antibodies against Infectious Bronchitis Virus in laying hens using egg yolk as substrate

    Directory of Open Access Journals (Sweden)

    RH Rauber

    2004-06-01

    Full Text Available The present work was carried out to compare Infectious Bronchitis Virus (IBV antibody titers in serum and egg yolk samples from laying hens. Sixty paired blood and egg samples were collected from laying hens of two farms. Serum samples were frozen, while egg yolk samples were diluted (1:500 before freezing. Serum and yolk samples were tested for the presence of IBV antibodies by indirect ELISA (commercial kit and titers were compared by a correlation test (alpha=0.05. There was a high correlation (r=0.62 between the two kinds of samples, which means that titers of IBV antibodies in the egg yolk and in serum samples are quite the same. Considering that blood collection causes deep stress that leads to economic losses, and since eggs are collected daily on the farm, results reported here are of importance to poultry production.

  17. Sialic Acid Binding Properties of Soluble Coronavirus Spike (S1 Proteins: Differences between Infectious Bronchitis Virus and Transmissible Gastroenteritis Virus

    Directory of Open Access Journals (Sweden)

    Christine Winter

    2013-07-01

    Full Text Available The spike proteins of a number of coronaviruses are able to bind to sialic acids present on the cell surface. The importance of this sialic acid binding ability during infection is, however, quite different. We compared the spike protein of transmissible gastroenteritis virus (TGEV and the spike protein of infectious bronchitis virus (IBV. Whereas sialic acid is the only receptor determinant known so far for IBV, TGEV requires interaction with its receptor aminopeptidase N to initiate infection of cells. Binding tests with soluble spike proteins carrying an IgG Fc-tag revealed pronounced differences between these two viral proteins. Binding of the IBV spike protein to host cells was in all experiments sialic acid dependent, whereas the soluble TGEV spike showed binding to APN but had no detectable sialic acid binding activity. Our results underline the different ways in which binding to sialoglycoconjugates is mediated by coronavirus spike proteins.

  18. Currently available cough suppressants for chronic cough.

    Science.gov (United States)

    Chung, Kian Fan

    2008-01-01

    Chronic cough is a common symptom but only a fraction of patients seek medical attention. Addressing the causes of chronic cough may lead to control of cough; however, this approach is not always successful since there is a certain degree of failure even when the cause(s) of cough are adequately treated; in idiopathic cough, there is no cause to treat. Persistent cough may be associated with deterioration of quality of life, and treatment with cough suppressants is indicated. Currently available cough suppressants include the centrally acting opioids such as morphine, codeine, and dextromethorphan. Peripherally acting antitussives include moguisteine and levodropropizine. Early studies report success in reducing cough in patients with chronic bronchitis or COPD; however, a carefully conducted study showed no effect of codeine on cough of COPD. Success with these cough suppressants can be achieved at high doses that are associated with side effects. Slow-release morphine has been reported to be useful in controlling intractable cough with good tolerance to constipation and drowsiness. There have been case reports of the success of centrally acting drugs such as amitryptiline, paroxetine, gabapentin, and carbamezepine in chronic cough. New opioids such as nociceptin or antagonists of TRPV1 may turn out to be more effective. Efficacy of cough suppressants must be tested in double-blind randomised trials using validated measures of cough in patients with chronic cough not responding to specific treatments. Patients with chronic cough are in desperate need of effective antitussives that can be used either on demand or on a long-term basis.

  19. Invasive Aspergillus infections in hospitalized patients with chronic lung disease

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    Wessolossky M

    2013-05-01

    Full Text Available Mireya Wessolossky,1 Verna L Welch,2 Ajanta Sen,1 Tara M Babu,1 David R Luke21Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, MA, USA; 2Medical Affairs, Pfizer Inc, Collegeville, PA, USABackground: Although invasive pulmonary aspergillosis (IPA is more prevalent in immunocompromised patients, critical care clinicians need to be aware of the occurrence of IPA in the nontraditional host, such as a patient with chronic lung disease. The purpose of this study was to describe the IPA patient with chronic lung disease and compare the data with that of immunocompromised patients.Methods: The records of 351 patients with Aspergillus were evaluated in this single-center, retrospective study for evidence and outcomes of IPA. The outcomes of 57 patients with chronic lung disease and 56 immunocompromised patients were compared. Patients with chronic lung disease were defined by one of the following descriptive terms: emphysema, asthma, idiopathic lung disease, bronchitis, bronchiectasis, sarcoid, or pulmonary leukostasis.Results: Baseline demographics were similar between the two groups. Patients with chronic lung disease were primarily defined by emphysema (61% and asthma (18%, and immunocompromised patients primarily had malignancies (27% and bone marrow transplants (14%. A higher proportion of patients with chronic lung disease had a diagnosis of IPA by bronchoalveolar lavage versus the immunocompromised group (P < 0.03. The major risk factors for IPA were found to be steroid use in the chronic lung disease group and neutropenia and prior surgical procedures in the immunocompromised group. Overall, 53% and 69% of chronic lung disease and immunocompromised patients were cured (P = 0.14; 55% of chronic lung patients and 47% of immunocompromised patients survived one month (P = 0.75.Conclusion: Nontraditional patients with IPA, such as those with chronic lung disease, have outcomes and mortality similar to that in the

  20. Multi-centre retrospective analysis of clinical diagnosis and treatment for chronic cough

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    Xiao-ming CHENG

    2011-02-01

    Full Text Available Objective To explore the clinical characteristics and the present status of diagnosis and treatment of chronic cough.Methods The clinical data of 238 in-patients and out-patients of Departments of Respiratory Diseases from 4 teaching hospitals of Chongqing Municipality were collected from Oct.2008 to Dec.2009,and their clinical characteristics,diagnosis and therapeutic effects were retrospectively analyzed.Results A total of 238 patients were enrolled,most of them complained of dry cough and night cough.Throat symptoms were most common,including itching or foreign body sensation,throat discomfort and gastro-oesophageal reflux.Congestion of pharynx and cobblestone like changes in posterior pharyngeal wall were the most common signs in patients with chronic cough.Among all the supplementary examinations,bronchial provocation test resulted in highest positive rate.Etiological diagnosis was done in a total of 254 case-times for diseases leading to chronic cough,among them upper airway cough syndrome(UACS was suspected in 115 case-times.cough variant asthma(CVA in 42 case-times,and cough due to gastroesophageal reflux(GERC in 53 case-times.After the specific treatment targeting UACS,CVA and GERC,in 152 case-times improvement was found after follow-up,including 56,27 and 21 case-times,respectively,with an effective rate of 68.4%(104/152.The final diagnosis for the other 44 case-times with chronic cough was chronic tonsillitis,chronic bronchitis,eosinophilic bronchitis and angiotensin converting enzyme inhibitor(ACEI induced cough.A definite diagnosis was finally made in 148 out of a total of 254 casses,with a diagnostic rate of 58.3%(148/254.Conclusion The final diagnostic rate in etiology of chronic cough is still poor nowadays in our country,and empirical treatment is still the main practice for chronic cough.

  1. Chronic cholecystitis

    Science.gov (United States)

    Cholecystitis - chronic ... Most of the time, chronic cholecystitis is caused by repeated attacks of acute (sudden) cholecystitis. Most of these attacks are caused by gallstones in the gallbladder. These ...

  2. Chronic Pain

    Science.gov (United States)

    ... pain. Psychotherapy, relaxation and medication therapies, biofeedback, and behavior modification may also be employed to treat chronic pain. × ... pain. Psychotherapy, relaxation and medication therapies, biofeedback, and behavior modification may also be employed to treat chronic pain. ...

  3. Chronic Pain

    Science.gov (United States)

    ... a problem you need to take care of. Chronic pain is different. The pain signals go on ... there is no clear cause. Problems that cause chronic pain include Headache Low back strain Cancer Arthritis ...

  4. Chronic prostatitis

    OpenAIRE

    Le, Brian; Schaeffer, Anthony J.

    2011-01-01

    Chronic prostatitis can cause pain and urinary symptoms, and usually occurs without positive bacterial cultures from prostatic secretions (known as chronic abacterial prostatitis or chronic pelvic pain syndrome [CP/CPPS]). Bacterial infection can result from urinary tract instrumentation, but the cause and natural history of CP/CPPS are unknown.

  5. Chronic prostatitis

    OpenAIRE

    Erickson, Bradley A.; Schaeffer, Anthony J.; Le, Brian

    2008-01-01

    Chronic prostatitis can cause pain and urinary symptoms, and usually occurs without positive bacterial cultures from prostatic secretions (known as chronic abacterial prostatitis or chronic pelvic pain syndrome, CP/CPPS). Bacterial infection can result from urinary tract instrumentation, but the cause and natural history of CP/CPPS are unknown.

  6. Relationship between the use of inhaled steroids for chronic respiratory diseases and early outcomes in community-acquired pneumonia.

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    Jordi Almirall

    Full Text Available BACKGROUND: The role of inhaled steroids in patients with chronic respiratory diseases is a matter of debate due to the potential effect on the development and prognosis of community-acquired pneumonia (CAP. We assessed whether treatment with inhaled steroids in patients with chronic bronchitis, COPD or asthma and CAP may affect early outcome of the acute pneumonic episode. METHODS: Over 1-year period, all population-based cases of CAP in patients with chronic bronchitis, COPD or asthma were registered. Use of inhaled steroids were registered and patients were followed up to 30 days after diagnosis to assess severity of CAP and clinical course (hospital admission, ICU admission and mortality. RESULTS: Of 473 patients who fulfilled the selection criteria, inhaled steroids were regularly used by 109 (23%. In the overall sample, inhaled steroids were associated with a higher risk of hospitalization (OR=1.96, p = 0.002 in the bivariate analysis, but this effect disappeared after adjusting by other severity-related factors (adjusted OR=1.08, p=0.787. This effect on hospitalization also disappeared when considering only patients with asthma (OR=1.38, p=0.542, with COPD alone (OR=4.68, p=0.194, but a protective effect was observed in CB patients (OR=0.15, p=0.027. Inhaled steroids showed no association with ICU admission, days to clinical recovery and mortality in the overall sample and in any disease subgroup. CONCLUSIONS: Treatment with inhaled steroids is not a prognostic factor in COPD and asthmatic patients with CAP, but could prevent hospitalization for CAP in patients with clinical criteria of chronic bronchitis.

  7. 支气管哮喘34例临床治疗体会%Clinical Treatment Experience of 34 Cases of Bronchitis Asthma

    Institute of Scientific and Technical Information of China (English)

    陈云

    2015-01-01

    Objective The clinical treatment of bronchitis asthma is to be investigated. Methods Review and analyze clinical treatment data selected from 34 bronchitis asthma patients who are treated in hospital from June 2013 to June 2014. Results Of the 34 patients with bronchitis asthma,there were 18 cured cases,10 cases of significant efficiency,4 cases of efficacy and 2 cases of inefficiency,the efficacy incidence was up to 94.12% in total. Conclusion Timely and effective treatment is of significance to improve patients’cure rate and quality of life.%目的:探讨支气管哮喘的临床治疗。方法对2012年6月~2014年6月收治的34例支气管哮喘患者的临床资料进行回顾性分析。结果34例支气管哮喘患者经治疗,治愈18例,显效10例,有效4例,无效2例,总有效率94.12%。结论对于支气管哮喘,应及时有效的治疗,提高治愈率和生活质量。

  8. 纤维索性支气管炎的诊治进展%The progress in diagnosis and treatmentment of plastic bronchitis

    Institute of Scientific and Technical Information of China (English)

    甘庆; 戴路明

    2015-01-01

    Plastic bronchitis is a rare but severe respiratory disease.Its major clinical manifestations and periodic haemoptysis are recurrent.When bronchial tube type coughs out,it can block airway,if can't be get out timely or treated effectively, it can rapidly cause severe respiratory distress, which can threaten the lives of patients.The disease is rare,and disease-related research is not much.This paper is to summary the progress in diagnosis and treatmentment of plastic bronchitis to provide the reference and basis for the clinical treatment of plastic bronchitis.%纤维素性支气管炎是一种罕见但病情严重的呼吸系统疾病,临床上主要表现为反复、周期性咯血.若咳出的支气管管型阻塞气道,不能得到及时、有效的治疗和控制,以至迅速引起严重的呼吸窘迫,对患者的生命产生威胁.因此病少见,与此病相关的研究也不多,本文主要对纤维素性支气管炎的诊治进展进行综述,以期为纤维素性支气管炎的临床治疗提供参考和依据.

  9. Clinical Practice Guidelines for Severe Chronic Obstructive Pulmonary Disease. Guía de práctica clínica para el tratamiento de la enfermedad pulmonar obstructiva crónica grave.

    Directory of Open Access Journals (Sweden)

    Inti Santana Carballosa

    2009-03-01

    Full Text Available Clinical Practice Guidelines for Severe Chronic Obstructive Pulmonary Disease. This concept includes simple chronic bronchitis, asthmatic bronchitis, chronic obstructive bronchitis, and pulmonary emphysema; although this two last are the most commonly included. Risk factors, classification and treatment are commented, stressing the strategy of mechanical ventilation and the indications for mechanical invasive and no invasive ventilation. It includes assessment guidelines focused on the most important aspects to be accomplished.Guía de práctica clínica para el tratamiento de la enfermedad pulmonar obstructiva crónica grave. Término que encierra a la bronquitis crónica simple, bronquitis asmática, bronquitis obstructiva crónica y enfisema pulmonar; aunque son las dos últimas las más comúnmente incluidas. Se comentan los factores de riesgo, clasificación y tratamiento con énfasis en la estrategia de ventilación mecánica, así como las indicaciones de ventilación mecánica invasiva y no invasiva. Concluye con su guía de evaluación, enfocada en los aspectos más importantes a cumplir.

  10. Proteomic analysis of chicken embryonic trachea and kidney tissues after infection in ovo by avian infectious bronchitis coronavirus

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    Kong Xiangang

    2011-03-01

    Full Text Available Abstract Background Avian infectious bronchitis (IB is one of the most serious diseases of economic importance in chickens; it is caused by the avian infectious coronavirus (IBV. Information remains limited about the comparative protein expression profiles of chicken embryonic tissues in response to IBV infection in ovo. In this study, we analyzed the changes of protein expression in trachea and kidney tissues from chicken embryos, following IBV infection in ovo, using two-dimensional gel electrophoresis (2-DE coupled with matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry (MALDI-TOF-TOF MS. Results 17 differentially expressed proteins from tracheal tissues and 19 differentially expressed proteins from kidney tissues were identified. These proteins mostly related to the cytoskeleton, binding of calcium ions, the stress response, anti-oxidative, and macromolecular metabolism. Some of these altered proteins were confirmed further at the mRNA level using real-time RT-PCR. Moreover, western blotting analysis further confirmed the changes of annexin A5 and HSPB1 during IBV infection. Conclusions To the best of our knowledge, we have performed the first analysis of the proteomic changes in chicken embryonic trachea and kidney tissues during IBV infection in ovo. The data obtained should facilitate a better understanding of the pathogenesis of IBV infection.

  11. Cloning and Sequencing of S Gene of Novel Variant of Infectious Bronchitis Virus ZJ971 Isolates in China

    Institute of Scientific and Technical Information of China (English)

    ZHOU Ji-yong; CHENG Li-qin; SHEN Xing-yan; DING Hong-mei; WU Jian-xiang

    2002-01-01

    A novel proventriculopathogic variant (isolate ZJ971) of infectious bronchitis virus (IBV) was identified from enlarged proeventriculus of the sick chickens in the study. The S gene cDNA segment with 3.6 kb in length was amplified by RT-PCR with special primers from the ZJ971 viral isolate of (IBV) and cloned into plasmid pBluescript SK( + ). The recombinants containing S gene of IBV-ZJ971 isotate were identified by digestion of restriction enzyme EcoRI, BamHI and PCR amplification. The cloned S gene from isolate IBVZJ971 was composed of 3492 bp in length encoding for a polypeptide of 1080 amino acids. Comparing the nucleotide of S gene of IBV isolate ZJ971 with that of reported IBV strains Beaudette, M41, Ark99 and CuT2,the homology was 97.3%, 97.5%, 88.6% and 85.6%, respectively; and the homology of the deduced amino acids of S protein of IBV isolate ZJ971 was 96%, 96.3%, 86.1% and 83.1% respectively; especially, the mutation of 3241st nucleotide of S gene of IBV isolate ZJ971 from G to T resulted in the translating termination of S protein at 3240th nucleotide site.

  12. Comparative histopathology and immunohistochemistry of QX-like, Massachusetts and 793/B serotypes of infectious bronchitis virus infection in chickens.

    Science.gov (United States)

    Benyeda, Zs; Szeredi, L; Mató, T; Süveges, T; Balka, Gy; Abonyi-Tóth, Zs; Rusvai, M; Palya, V

    2010-11-01

    The aim of this study was to compare experimentally the pathogenicity and tissue distribution of the recently emerged QX-like strain of infectious bronchitis virus (IBV) with the widespread M41 and 793/B serotypes of the virus. Histopathological and immunohistochemical methods were employed to define the main sites of virus replication. One-day-old specific pathogen free chickens were inoculated with five different QX-like strains, or with the M41 and 793/B IBV strains and monitored for 42 days post-infection. Tracheal lesions developed in all infected birds, confirming the ability of all of the tested strains to induce respiratory disease. Replication of the isolates in the alimentary tract was detected, but the infection did not cause significant gut lesions. Four of the five QX-like IBV strains induced severe kidney lesions. Dilation of the oviduct with accumulation of serum-like fluid in the lumen of this structure, reported previously from field cases of QX-like IBV infection, was observed following experimental infection with all of the five QX-like strains. Microscopical and immunohistochemical examination of the affected oviducts did not help to elucidate the pathogenesis of this lesion.

  13. The presence of viral subpopulations in an infectious bronchitis virus vaccine with differing pathogenicity--a preliminary study.

    Science.gov (United States)

    Hewson, Kylie A; Scott, Peter C; Devlin, Joanne M; Ignjatovic, Jagoda; Noormohammadi, Amir H

    2012-06-13

    There are currently four commercially available vaccines in Australia to protect chickens against infectious bronchitis virus (IBV). Predominantly, IBV causes clinical signs associated with respiratory or kidney disease, which subsequently cause an increase in mortality rate. Three of the current vaccines belong to the same subgroup (subgroup 1), however, the VicS vaccine has been reported to cause an increased vaccinal reaction compared to the other subgroup 1 vaccines. Molecular anomalies detected in VicS suggested the presence of two major subspecies, VicS-v and VicS-del, present in the commercial preparation of VicS. The most notable anomaly is the absence of a 40 bp sequence in the 3'UTR of VicS-del. In this investigation, the two subspecies were isolated and shown to grow independently and to similar titres in embryonated chicken eggs. An in vivo investigation involved 5 groups of 20 chickens each and found that VicS-del grew to a significantly lesser extent in the chicken tissues collected than did VicS-v. The group inoculated with an even ratio of the isolated subspecies scored the most severe clinical signs, with the longest duration. These results indicate the potential for a cooperative, instead of an expected competitive, relationship between VicS-v and VicS-del to infect a host, which is reminiscent of RNA viral quasi-species.

  14. Application of Irwin diagnostic procedures for chronic cough

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    Guo-fang FENG

    2011-07-01

    Full Text Available Objective To explore the advantages and disadvantages of the diagnostic procedures suggested by the Irwin group,and summarize the experiences in diagnosis and treatment,and to beter understand the etiology,diagnosis,differential diagnosis and treatment of chronic cough.Methods Data of 118 patients,who were finally diagnosed as chronic cough according to the diagnostic procedures suggested by Irwin group in the First Affiliated Hospital of General Hospital of PLA in 2009,were retrospectivety analyzed.Results With the Irwin diagnostic procedures of chronic cough,118 patients were diagnosed definitely.The final diagnostic rate reached 100%.The duration to reach the final diagnosis was 1 day to 30 days.Of the 118 patients with chronic cough,113 were cured(96%.32 cases(27.1% were caused by asthma and related diseases(allergic rhinitis,allergic pharyngitis,cough variant asthma and eosinophilic bronchitis;28 cases(23.7% were due to upper airway cough syndrome and related diseases(chronic rhinitis,sinusitis,pharyngeal bursitis,postnasal drip syndrome,chronic laryngitis,and vocal cord polyps;23 cases(19.5% due to gastroesophageal reflux disease;14 cases(11.9% due to lower respiratory tract infection and related diseases(endobronchial tuberculosis,pulmonary tuberculosis,endotracheal mucosal adenocarcinoma,lung cancer,bronchiectasis,and pulmonary fibrosis;10 cases(8.5% due to cardiac insafficiency;6 cases(5.1% due to administration of angiotensin-converting enzyme inhibitor(ACEI-like antihypertensive agents;3 cases(2.5% were psychogenic cough,and 2 cases(1.7% were induced by other causes.Conclusions The Irwin diagnosis of chronic cough is a comprehensive and thorough procedure,and it should be used with delibcration in clinic.The etiology of chronic cough is complicated,mainly including asthma and related diseases,sinusitis and upper airway cough syndrome,and gastroesophageal reflux disease.

  15. [Chronicity, chronicization, systematization of delusions].

    Science.gov (United States)

    Trapet, P; Fernandez, C; Galtier, M C; Gisselmann, A

    1984-05-01

    Chronicity in psychopathology is indicative of a term, a decay. Chronicization only leads the way to this term. Here, chronicization is taken literally as an inscription in the time course of delusions. The mechanism of systematization seems to be a central mark in the approach to chronic delusions. It is not an alienation or an irreversible closing but an attempted accommodation with reality in the life of psychotic subjects, irrespective of the delusional structure. The role of therapy and drug treatment as a follow-up may in that case assume another meaning.

  16. Chronic pancreatitis

    OpenAIRE

    Kocher, Hemant M.; Froeling, Fieke EM

    2008-01-01

    Chronic pancreatitis is characterised by long-standing inflammation of the pancreas owing to a wide variety of causes, including recurrent acute attacks of pancreatitis. Chronic pancreatitis affects 3–9 people in 100,000; 70% of cases are alcohol-induced.

  17. Chronic pancreatitis

    OpenAIRE

    Kocher, Hemant M.; Kadaba, Raghu

    2011-01-01

    Chronic pancreatitis is characterised by long-standing inflammation of the pancreas due to a wide variety of causes, including recurrent acute attacks of pancreatitis. Chronic pancreatitis affects between 3 and 9 people in 100,000; 70% of cases are alcohol-induced.

  18. Infectious bronchitis virus: dominance of ArkDPI-type strains in the United States broiler industry during the last decade

    Directory of Open Access Journals (Sweden)

    H Toro

    2010-06-01

    Full Text Available In the United States, more than 90% of chicken meat is produced in the southeastern states, and most egg production resides in the eastern half of the country and Texas. Several molecular epidemiological studies have indicated that most infectious bronchitis (IB virus (IBV isolates obtained from outbreaks of respiratory disease in these regions correspond to Ark-type IBV in spite of extensive vaccination programs which include IBV ArkDPI-derived vaccines. Accumulating evidence suggests that Ark-type strains may have a distinct capacity to circumvent preventive measures. Two strategies by which Ark-type IBV strains may maintain a high prevalence in commercial chickens are: (1 Unusually high genetic and phenotypic variability, and (2 synergism with concurrent viral immunodeficiency. Support for the first strategy includes epidemiological findings showing continued isolations of Ark-like viruses from respiratory disease affecting flocks vaccinated with serotype-specific homologous (ArkDPI-derived vaccines, experimental data demonstrating selection of new predominant phenotypes occurring rapidly after a single passage in the host, and recent findings indicating changes of the predominant IBV population occurring within the host during the invasion process. The second strategy is supported by epidemiological data indicating increased isolations of Ark-type IBV showing minor geno-/phenotypic variation occurring in chickens simultaneously affected by immunosuppressive viruses. In addition, experimental results have shown that viral immunodeficiency leads to more severe and prolonged IB signs and lesions, delayed and reduced specific antibody responses, and increased and persistent IBV shedding. Finally, accumulating evidence confirms high genetic and phenotypic heterogeneity in commercial ArkDPI-derived vaccines. The rapid selection of new predominant phenotypes occurring in these vaccines may be facilitating the emergence of Ark-like strains. Thus

  19. Efficacy of Add-on Montelukast in Nonasthmatic Eosinophilic Bronchitis: The Additive Effect on Airway Inflammation, Cough and Life Quality

    Institute of Scientific and Technical Information of China (English)

    Wuping Bao; Ping Liu; Zhongmin Qiu; Li Yu; Jingqing Hang; Xiaohua Gao; Xin Zhou

    2015-01-01

    Background:The efficacy of montelukast (MONT),a cysteinyl leukotriene receptor antagonist,in nonasthmatic eosinophilic bronchitis (NAEB),especially its influence on cough associated life quality is still indefinite.We evaluated the efficacy of MONT combined with budesonide (BUD) as compared to BUD monotherapy in improving life quality,suppressing airway eosinophilia and cough remission in NAEB.Methods:A prospective,open-labeled,multicenter,randomized controlled trial was conducted.Patients with NAEB (aged 18-75 years) were randomized to inhaled BUD (200 μg,bid) or BUD plus oral MONT (10 μg,qn) for 4 weeks.Leicester cough questionnaire (LCQ) life quality scores,cough visual analog scale (CVAS) scores,eosinophil differential ratio (Eos),and eosinophil cationic protein (ECP) in induced sputum were monitored and compared.Results:The control and MONT groups contained 33 and 32 patients,respectively,with similar baseline characteristics.Significant with-in group improvement in CVAS,LCQ scores,Eos,and ECP was observed in both groups during treatment.After 2-week treatment,add-on treatment of MONT was significantly more effective than BUD monotherapy for CVAS decrease and LCQ scores improvement (both P < 0.05).Similar results were seen at 4-week assessment (both P < 0.05).4-week add-on therapy of MONT also resulted in a higher percentage of patients with normal sputum Eos (<2.5%) and greater decrease of ECP (both P < 0.05).Conclusions:MONT combined with BUD was demonstrated cooperative effects in improvement of life quality,suppression ofeosinophilic inflammation,and cough remission in patients with NAEB.

  20. Increased expression of Interleukin-6 related to nephritis in chickens challenged with an Avian infectious bronchitis virus variant

    Directory of Open Access Journals (Sweden)

    Filipe S. Fernando

    2015-03-01

    Full Text Available A Brazilian field isolate (IBV/Brazil/PR05 of avian infectious bronchitis virus (IBV, associated with development of nephritis in chickens, was previously genotyped as IBV variant after S1 gene sequencing. The aim of this study was to evaluate the levels of IL-6 in kidneys and trachea of birds vaccinated and challenged with IBV/Brazil/PR05 strain, correlating these results with scores of microscopic lesions, specific IBV antigen detection and viral load. The up-regulation of IL-6 and the increased levels of viral load on renal and tracheal samples were significantly correlated with scores of microscopic lesions. Reduced levels of viral load were detected in kidneys of birds previously vaccinated and challenged, compared to non-vaccinated challenged group, although markedly microscopic lesions were observed for both groups. The expression of IL-6, present both in the kidney and in the tracheas, was dependent on the load of the virus present in the tissue, and the development of lesions was related with IL-6 present in the tissues. These data suggest that variant IBV/Brazil/PR05 can induce the expression of proinflammatory cytokines in a manner correlated with viral load and increased IL-6 is involved in the tissue with the influx of inflammatory cells and subsequent nephritis. This may contribute with a model to the development of immunosuppressive agents of IL-6 to prevent acute inflammatory processes against infection with IBV and perhaps other coronaviruses, as well as contribute to the understanding of the immunopathogenesis of IBV nephropatogenic strains.

  1. Molecular characterization of infectious bronchitis viruses isolated from broiler and layer chicken farms in Egypt during 2012

    Directory of Open Access Journals (Sweden)

    Karim Selim

    2013-12-01

    Full Text Available One of the major problems of avian infectious bronchitis virus (IBV is the frequent emergence of new variants. In the present study 205 tracheal swabs and organs were collected from broilers and layers chicken farms during January to August 2012 from 19 governorates all over Egypt. The chickens demonstrated respiratory signs and mortality. Out of the examined samples, 130 of which (about 64% of suspected farms were positive for IBV with real time RT-PCR. 13 IBV-positive samples were selected for further isolation and characterization. Isolation in specific pathogen free (SPF embryos was carried out after studies three blind successive passages and the hypervariable region of spike protein1 (SP1 was amplified by RT-PCR and sequenced to study the genetic diversity between the isolated viruses. Phylogenetic analysis of the obtained sequences of 13 isolates compared with other IBV strains from the Middle East and worldwide reveled that 11 out of the 13 isolates had close relationship the Israeli variants (IS/885 and IS/1494/06 with nucleotide homology reached up to 89.9% and 82.3%, respectively. Only two isolates had close relationship with CR/88121 and 4/91 viruses with identities of 95% and 96%, respectively. This study indicates existence of two variant groups of IBV circulating in Egypt during 2012. Group I was similar but distinguishable from Israeli variant IS/885 and group II was related to 4/91 and CR/88121 vaccine strains. There was no geographical link between the 2 groups as they were distributed all over the country. These findings necessitate the need to revise the vaccination programs and control measures for IBV.

  2. Bronquite plástica em criança com talassemia alfa Plastic bronchitis in a child with thalassemia alpha

    Directory of Open Access Journals (Sweden)

    Tiago N. Veras

    2005-12-01

    Full Text Available OBJETIVO: A bronquite plástica é uma doença infreqüente na criança, sendo caracterizada por moldes ou cilindros mucofibrinosos na árvore traqueobrônquica. Faz parte do diagnóstico diferencial de crianças com insuficiência respiratória de início agudo, e o tratamento precoce é importante para a resolução do quadro. O objetivo deste relato é descrever um caso de bronquite plástica tratado com sucesso por endoscopia, em paciente portador de talassemia alfa. DESCRIÇÃO: Criança do sexo masculino, 3 anos de idade, sem antecedentes mórbidos significativos, apresentou quadro de insuficiência respiratória aguda, com achados radiológicos de atelectasia pulmonar sugestivos de aspiração de corpo estranho. Não havia sintomas respiratórios ou antecedentes de alergia ou infecções respiratórias de repetição. A realização de broncoscopia flexível, complementada por endoscopia rígida e exame anatomopatológico, evidenciou a presença de bronquite plástica. Após a realização da endoscopia, a criança evoluiu satisfatoriamente, com curva térmica afebril e extubação em 72 horas. Foram utilizadas medicações sintomáticas, sem necessidade de antimicrobianos. Dez dias após a alta, a radiografia de tórax encontrava-se normal. A talassemia alfa foi diagnosticada através da eletroforese de hemoglobina. COMENTÁRIOS: A importância clínica da bronquite plástica reside no fato de apresentar um quadro semelhante ao de outras doenças mais prevalentes, como a aspiração de corpo estranho e a asma brônquica. A suspeita do quadro recomenda a realização de endoscopia para diagnóstico e tratamento. É reconhecida a ocorrência de bronquite plástica em crianças com fibrose cística, pós-operatório de cirurgia cardíaca e anemia falciforme. No presente artigo, foi observada uma associação com talassemia alfa.OBJECTIVE: Plastic bronchitis is an unusual condition in children, associated with formation of mucofibrinous

  3. Effectiveness of anti-inflammatory treatment versus antibiotic therapy and placebo for patients with non-complicated acute bronchitis with purulent sputum. The BAAP Study protocol

    Directory of Open Access Journals (Sweden)

    Fernández Yvonne

    2011-06-01

    Full Text Available Abstract Background Acute bronchitis is one of the most prevalent respiratory infections in primary care, and in more than 90% of the cases antibiotics are prescribed, mainly when purulent expectoration is present. However, this process is usually viral in origin and the benefits of antibiotic treatment are marginal. On the other hand, in recent years bronchitis has been considered more as an inflammatory than an infectious process. Thus, the aim of this study is to evaluate the clinical effectiveness of a schedule of an oral anti-inflammatory compared with an antibiotic regimen and another group assigned to receive a placebo. Methods and design A total of 420 patients from 15 to 70 years of age with no associated comorbidity, presenting respiratory tract infection of at least one week of evolution, with cough as the predominant symptom, the presence of purulent expectoration and at least one other symptom of the respiratory tract (dyspnoea, wheezing, chest discomfort or pain, with no alternative explanation such as pneumonia, will be included in a prospective, randomised and controlled, clinical trial with placebo. The patients will be randomised to receive one of three treatments: ibuprofen, amoxycillin and clavulanic acid or placebo for 10 days. The main outcome measure is the number of days with frequent cough defined by the symptom diary with a score of 1 or more. Discussion This trial is designed to evaluate the number of days with frequent cough with anti-inflammatory treatment compared with antimicrobial treatment and placebo in previously healthy patients with a clinical picture of acute bronchitis and purulent expectoration. It is hypothesized that anti-inflammatory treatment is more effective than antibiotic treatment to reduce cough, which is the most disturbing symptom for patients with this infection. Trial registration ISRCTN07852892

  4. Application Study on Doxofylline in the Treatment of Bronchitis%多索茶碱在支气管炎治疗中的应用研究

    Institute of Scientific and Technical Information of China (English)

    解秀文

    2015-01-01

    Objective To study the application effect of doxofyl ine in the treatment of bronchitis. Methods 40 patients with bronchitis from February 2014 to February 2015 in our hospital were selected into two groups according to different medication treatment. 20 patients in study group are given doxofyl ine medication treatment,while 20 patients in control group are given aminophyl ine medication treatment,then the treatment effects between two groups were observed and compared. Results The relief time of gasp,coughing and expectoration in study group were shorter than control group significantly(P<0.05),and effective rate in study group was higher than that in control group(P<0.05). Conclusion The application effect of doxofyl ine in the treatment of bronchitis is better,the effective rate is higher;thus,such a treatment method is quite worthwhile to be promoted and applied widespread.%目的:研究多索茶碱在支气管炎治疗中的应用效果。方法搜集我院2014年2月~2015年2月支气管炎40例,依据治疗用药不同将其分两组。实验组20例,治疗用药选择多索茶碱;对照组20例,治疗用药选择氨茶碱。观察两组效果,比较分析。结果实验组喘息、咳嗽及咳痰缓解时间较短(P<0.05),治疗有效率高(P<0.05),存在差异。结论多索茶碱在支气管炎治疗中应用效果佳,有效率高。

  5. Detection and strain differentiation of infectious bronchitis virus in tracheal tissues from experimentally infected chickens by reverse transcription-polymerase chain reaction. Comparison with an immunohistochemical technique

    DEFF Research Database (Denmark)

    Handberg, Kurt; Nielsen, O.L.; Pedersen, M.W.;

    1999-01-01

    Oligonucleotide pairs were constructed for priming the amplification of fragments of nucleocapsid (N) protein and spike glycoprotein (S) genes of avian infectious bronchitis virus (IBV) by reverse transcription-polymerase chain reaction (RT-PCR). One oligonucleotide pair amplified a common segment......3896 and 793B strains of IBV, respectively, Groups of specific pathogen free chickens were experimentally inoculated with the Massachusetts (H120, M41), the D1466 and the 793B strains of IBV, and tracheal tissue preparations were made from each bird for RT-PCR and for immunohistochemistry (IHC) up to 3...

  6. [Atmospheric pollution and chronic respiratory diseases in the blast-furnace areas of iron-works].

    Science.gov (United States)

    Zannini, D; Valente, T; Rotunno, R; Giusto, R

    1977-01-01

    An epidemiologic research together with a study on the environmental pollution were carried out in order to evaluate the risk of chronic respiratory diseases of blast furnace workers. The environment study was performed mainly using personal samplers given to workers with different jobs. Observations on 222 work shifts have shown that the total dust concentration to which cast workmen, maintenance men and blast furnace service men were exposed, marginally exceed the TLV values. Furthermore the level of respirable dusts for blast furnace service men was found slightly excessive. The average SO2 concentration was largely below the TLV values. However this gas could be found in excess for very short periods during the work. The epidemiologic study, conducted on a cohort of blast furnace area workers against a control group cohort, indicated a moderate prevalence of pneumoconiosis and chronic bronchitis amongst blast furnaces workers. The clinic and radiological pictures do not seem to go beyond the initial stages.

  7. Peak flow as predictor of overall mortality in asthma and chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Hansen, Ejvind Frausing; Vestbo, Jørgen; Phanareth, K

    2001-01-01

    Lung function is a strong predictor of overall mortality in asthma and chronic obstructive pulmonary disease (COPD). FEV1 is considered to be the "gold standard," whereas peak expiratory flow (PEF) is mostly used in absence of FEV1 measurements. We compared the predictive power of PEF and FEV1...... of best PEF was in part maintained after controlling for best FEV1. In asthma, best FEV1 seemed to be a better predictor of mortality than best PEF. Despite close correlation to FEV1, PEF apparently provides independent prognostic information in patients with COPD. This may be due to PEF and FEV1...... reflecting different components of COPD, i.e., chronic bronchitis, small airways disease, and emphysema. Furthermore, extrapulmonary components such as muscle mass and general "vigour" probably affect PEF to a greater extent than they affect FEV1....

  8. Gastro-esophageal reflux disease and exacerbations in chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Ingebrigtsen, Truls S; Marott, Jacob L; Vestbo, Jørgen;

    2015-01-01

    BACKGROUND AND OBJECTIVE: We tested the hypothesis that gastro-esophageal reflux disease is a risk factor for exacerbations in individuals with chronic obstructive pulmonary disease (COPD). METHODS: Among 9622 participants in the Copenhagen City Heart Study, we identified 1259 individuals with COPD...... and information on gastro-esophageal reflux disease and the regular use of acid inhibitory treatment. These individuals were followed for 5 years with regard to medically treated COPD exacerbations, which we defined as a short course treatment with oral corticosteroids alone or in combination with antibiotics. We...... applied a multivariable Cox regression analysis with adjustment for well-established risk factors associated with COPD exacerbations or gastro-esophageal reflux disease, including COPD severity, and symptoms. RESULTS: Individuals with COPD and gastro-esophageal reflux disease had more chronic bronchitis...

  9. Ear infection - chronic

    Science.gov (United States)

    Middle ear infection - chronic; Otitis media - chronic; Chronic otitis media; Chronic ear infection ... up. When this happens, infection can occur. A chronic ear infection develops when fluid or an infection ...

  10. Recombinant infectious bronchitis virus (IBV) H120 vaccine strain expressing the hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) protects chickens against IBV and NDV challenge.

    Science.gov (United States)

    Yang, Xin; Zhou, Yingshun; Li, Jianan; Fu, Li; Ji, Gaosheng; Zeng, Fanya; Zhou, Long; Gao, Wenqian; Wang, Hongning

    2016-05-01

    Infectious bronchitis (IB) and Newcastle disease (ND) are common viral diseases of chickens, which are caused by infectious bronchitis virus (IBV) and Newcastle disease virus (NDV), respectively. Vaccination with live attenuated strains of IBV-H120 and NDV-LaSota are important for the control of IB and ND. However, conventional live attenuated vaccines are expensive and result in the inability to differentiate between infected and vaccinated chickens. Therefore, there is an urgent need to develop new efficacious vaccines. In this study, using a previously established reverse genetics system, we generated a recombinant IBV virus based on the IBV H120 vaccine strain expressing the haemagglutinin-neuraminidase (HN) protein of NDV. The recombinant virus, R-H120-HN/5a, exhibited growth dynamics, pathogenicity and viral titers that were similar to those of the parental IBV H120, but it had acquired hemagglutination activity from NDV. Vaccination of SPF chickens with the R-H120-HN/5a virus induced a humoral response at a level comparable to that of the LaSota/H120 commercial bivalent vaccine and provided significant protection against challenge with virulent IBV and NDV. In summary, the results of this study indicate that the IBV H120 strain could serve as an effective tool for designing vaccines against IB and other infectious diseases, and the generation of IBV R-H120-HN/5a provides a solid foundation for the development of an effective bivalent vaccine against IBV and NDV.

  11. Protection conferred by a recombinant Marek’s disease virus that expresses the spike protein from infectious bronchitis virus in specific pathogen-free chicken

    Directory of Open Access Journals (Sweden)

    Zhang Xiaorong

    2012-05-01

    Full Text Available Abstract Background In many countries, the predominant field isolates of infectious bronchitis virus (IBV have been classified as QX-like strains since 1996. However, no commercial vaccines that are specific for this type of IBV are currently available. Therefore, there is an urgent need to develop novel vaccines that prevent QX-like IBV infection. Results A recombinant Marek’s disease virus (MDV, rMDV-S1, that expresses the S1 subunit of the spike (S protein from the QX-like infectious bronchitis virus (IBV was constructed by inserting the IBV S1 gene into the genome of the CVI988/Rispens strain of MDV. Specific pathogen-free (SPF chickens that were vaccinated with rMDV-S1 were protected when challenged with the QX-like IBV. They were observed to have mild clinical signs of disease, a short virus-shedding period and low mortality. Additionally, the rMDV-S1 conferred full protection to chickens against virulent MDV, as did the CVI988/Rispens strain. Conclusions Our results demonstrate that rMDV-S1 is an effective and promising recombinant vaccine for the prevention of QX-like IBV infection.

  12. Valuing the Economic Costs of Allergic Rhinitis, Acute Bronchitis, and Asthma from Exposure to Indoor Dampness and Mold in the US

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    David H. Mudarri

    2016-01-01

    Full Text Available Two foundational methods for estimating the total economic burden of disease are cost of illness (COI and willingness to pay (WTP. WTP measures the full cost to society, but WTP estimates are difficult to compute and rarely available. COI methods are more often used but less likely to reflect full costs. This paper attempts to estimate the full economic cost (2014$ of illnesses resulting from exposure to dampness and mold using COI methods and WTP where the data is available. A limited sensitivity analysis of alternative methods and assumptions demonstrates a wide potential range of estimates. In the final estimates, the total annual cost to society attributable to dampness and mold is estimated to be $3.7 (2.3–4.7 billion for allergic rhinitis, $1.9 (1.1–2.3 billion for acute bronchitis, $15.1 (9.4–20.6 billion for asthma morbidity, and $1.7 (0.4–4.5 billion for asthma mortality. The corresponding costs from all causes, not limited to dampness and mold, using the same approach would be $24.8 billion for allergic rhinitis, $13.5 billion for acute bronchitis, $94.5 billion for asthma morbidity, and $10.8 billion for asthma mortality.

  13. Comparison of sequences of hypervariable region (HVR subunit S-1 gene of field isolate I-37 infectious bronchitis virus with Connecticut serotype

    Directory of Open Access Journals (Sweden)

    N.L.P Indi Dharmayanti

    2003-06-01

    Full Text Available Infectious Bronchitis is a contagious and acute respiratory disease in chickens caused by infectious bronchitis virus (IBV.Antigenic differences in IBV are associated with changes in the sequence of the spike glycoprotein (S. The subunit S1 which demonstrates more sequence variability than S-2 have been identified as hypervariable region (HVR-1 and 2. There were several IB virus field isolates included I-37 have been identified in Indonesia by serum neutralization method. However, gene sequence variation in HVR subunit S-1 had not yet been identified. Isolate I-37 was close to the serotype Connecticut 46 (Conn 46. The aim of this study is to identify sequence variation of HVR subunit S-1 gene of isolate I-37 produced by Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR and sequencing. Several procedures were carried out in the study including virus titration, propagation and was concentrated from the allantoic fluid infected with IBV. Then, RNA was extracted for RTPCR. urther the product was sequnced and its homology with IBV references from GenBank was compared by GenMac version 8.0. Result showed that isolate I-37 produced 515 bp of amplification product. Isolate I-37 and Conn 46 are same serotype, yet their HVR subunit S-1 nucleotides and amino acids (protein differ by 6.9% and 15.6% respectively. It might be concluded that isolate I-37 was variant of Conn 46.

  14. Elucidation of the avian nucleolar proteome by quantitative proteomics using SILAC and changes in cells infected with the coronavirus infectious bronchitis virus.

    Science.gov (United States)

    Emmott, Edward; Smith, Catriona; Emmett, Stevan R; Dove, Brian K; Hiscox, Julian A

    2010-10-01

    The nucleolus is a dynamic subnuclear compartment involved in ribosome subunit biogenesis, regulation of cell stress and modulation of cellular growth and the cell cycle, among other functions. The nucleolus is composed of complex protein/protein and protein/RNA interactions. It is a target of virus infection with many viral proteins being shown to localize to the nucleolus during infection. Perturbations to the structure of the nucleolus and its proteome have been predicted to play a role in both cellular and infectious disease. Stable isotope labeling with amino acids in cell culture coupled to LC-MS/MS with bioinformatic analysis using Ingenuity Pathway Analysis was used to investigate whether the nucleolar proteome altered in virus-infected cells. In this study, the avian nucleolar proteome was defined in the absence and presence of virus, in this case the positive strand RNA virus, avian coronavirus infectious bronchitis virus. Data sets, potential protein changes and the functional consequences of virus infection were validated using independent assays. These demonstrated that specific rather than generic changes occurred in the nucleolar proteome in infectious bronchitis virus-infected cells.

  15. An intervention with access to C-reactive protein rapid test reduces antibiotic overprescribing in acute exacerbations of chronic bronchitis and COPD

    DEFF Research Database (Denmark)

    F. Strykowski, David; Nielsen, Anni Brit Sternhagen; Llor, Carles

    2015-01-01

    to a multifaceted intervention and given access to C-reactive protein (CRP) rapid test; partial-intervention group (PIG) was only exposed to the multifaceted intervention. Overprescribing was defined as antibiotic given to type III* exacerbation (≤ one Anthonisen Criteria); underprescribing was defined...

  16. Intake of high fructose corn syrup sweetened soft drinks is associated with prevalent chronic bronchitis in U.S. Adults, ages 20–55 y

    OpenAIRE

    DeChristopher, Luanne Robalo; Uribarri, Jaime; Tucker, Katherine L

    2015-01-01

    Background High fructose corn syrup (HFCS) sweetened soft drink intake has been linked with asthma in US high-schoolers. Intake of beverages with excess free fructose (EFF), including apple juice, and HFCS sweetened fruit drinks and soft drinks, has been associated with asthma in children. One hypothesis for this association is that underlying fructose malabsorption and fructose reactivity in the GI may contribute to in situ formation of enFruAGEs. EnFruAGEs may be an overlooked source of adv...

  17. [Chronic hepatitis].

    Science.gov (United States)

    Figueroa Barrios, R

    1995-01-01

    Medical literature about chronic hepatitis is reviewed. This unresolving disease caused by viruses, drugs or unknown factors may progress to in cirrhosis and hepatocarcinoma. A classification based on liver biopsy histology into chronic persistent and chronic active types has been largely abandoned and emphasis is placed on recognizing the etiology of the various types. One is associated with continuing hepatitis B virus infection; another is related to chronic hepatitis C virus infection and the third is termed autoinmune, because of the association with positive serum autoantibodies. A fourth type with similar clinical functional and morphologic features is found with some drug reactions. Long term corticoesteroid therapy is usually successful in autoinmune type. Associations between antibodies to liver-kidney microsomes and the hepatitis C virus can cause diagnostic difficulties. Antiviral treatment of chronic hepatitis B and C with interpheron alfa is employed, controlling symptoms and abnormal biochemistry and the progression to cirrhosis and liver cancer in 30 to 40% patients. Alternative therapies or combinations with interpheron are being evaluated waiting for final results.

  18. 拔罐治疗支气管炎及哮喘137例的临床疗效%The clinical effect of cupping treatment on 137 cases of bronchitis and asthma

    Institute of Scientific and Technical Information of China (English)

    韩芳

    2015-01-01

    Objective:To investigate the curative effect of cupping in the treatment of bronchitis and asthma.Method:137 cases of bronchitis and asthma were selected from 2012 to 2014.Taking cupping therapy using glass cupping.Results:The total efficiency of cupping on the treatment of bronchitis and asthma was 93.43%.Conclusion:Cupping on the treatment of bronchitis and asthma has the effect of expelling wind and cold,and clearing the lung,stop screaming and asthma,strengthening body resistance,and it also can improve the symptoms.%目的:探讨拔罐治疗支气管炎及哮喘的疗效。方法:2012-2014年收治支气管炎及哮喘患者137例,用玻璃制火罐留罐治疗。结果:拔罐治疗支气管炎及哮喘总有效率93.43%。结论:拔罐治疗支气管炎及哮喘可祛风散寒肃肺,止啸平喘,扶正培本及改善症状。

  19. Chronic gastritis.

    Science.gov (United States)

    Sipponen, Pentti; Maaroos, Heidi-Ingrid

    2015-06-01

    Prevalence of chronic gastritis has markedly declined in developed populations during the past decades. However, chronic gastritis is still one of the most common serious pandemic infections with such severe killing sequelae as peptic ulcer or gastric cancer. Globally, on average, even more than half of people may have a chronic gastritis at present. Helicobacter pylori infection in childhood is the main cause of chronic gastritis, which microbial origin is the key for the understanding of the bizarre epidemiology and course of the disease. A life-long and aggressive inflammation in gastritis results in destruction (atrophic gastritis) of stomach mucosa with time (years and decades). The progressive worsening of atrophic gastritis results subsequently in dysfunctions of stomach mucosa. Atrophic gastritis will finally end up in a permanently acid-free stomach in the most extreme cases. Severe atrophic gastritis and acid-free stomach are the highest independent risk conditions for gastric cancer known so far. In addition to the risks of malignancy and peptic ulcer, acid-free stomach and severe forms of atrophic gastritis may associate with failures in absorption of essential vitamins, like vitamin B12, micronutrients (like iron, calcium, magnesium and zinc), diet and medicines.

  20. Chyloptysis causing plastic bronchitis

    Directory of Open Access Journals (Sweden)

    Alice Stoddart

    2014-01-01

    Full Text Available Chyloptysis is a rare clinical problem that is associated with conditions affecting lymphatic channels in the thorax. Diagnosis is usually made when the patients present with expectoration of milky-white sputum or of thick tenacious mucus in the shape of smaller bronchi (bronchial cast. Typically the symptoms resolve after coughing up of the bronchial casts. Pleural, mediastinal, pulmonary or lymphatic abnormalities result in chyloptysis. Lymphangiography and detection of lipids (cholesterol or triglycerides in sputum help to establish the diagnosis. However, lymphangiography may not be positive in all patients. We report 2 patients with chyloptysis and bronchial casts with different etiologies. Abnormal lymphatics were demonstrated in one of our cases, but the second patients lymphangiogram was normal. In this patient we suspect that high venous filling pressures due to congestive heart failure had a causative effect in the setting of compromised lymphatic drainage in the thorax due to a prior history of radiation therapy to the chest for lymphoma.

  1. The diagnosis and treatment of plastic bronchitis in children with status asthmaticus%儿童哮喘持续状态下的塑型性支气管炎

    Institute of Scientific and Technical Information of China (English)

    梁金鑫; 张琪; 胡凤华

    2012-01-01

    目的 研究哮喘持续状态患儿中塑型性支气管炎的发病特点,探讨其诊断和治疗方法.方法 从2008年1月至2011年5月收治4例哮喘持续状态合并塑型性支气管炎的患儿,回顾性分析其发病病因、临床特点、病原学、治疗过程及治疗效果.结果 4例患儿中行急诊纤维支气管镜检查3例,所有取出异物行病理检查,诊断为塑型性支气管炎,这4例患儿经气管插管、呼吸支持、纤维支气管镜灌洗、呼吸道管理及抗感染治疗,均痊愈出院.结论 确诊塑型性支气管炎需依靠支气管镜检查和病理组织学检查.哮喘持续状态患儿要高度警觉塑型性支气管炎的发生.%Objective To investigate the clinical characteristics, diagnosis and therapeutic approaches of plastic bronchitis in children with status asthmaticus. Methods The clinical profiles of 4 children with plastic bronchitis and plastic bronchitis admitted to Capital Institute of Pediatrics from Jan 2008 to May 2011 were retrospectively analyzed. Results Of 4 patients with plastic bronchitis, three received bronchoseope inspection, and all of them were confirmed plastic bronchitis by histopathology, and cured after mechanical ventdation, airway management and anti-infection treatment. Conclusion Plastic bronchitis diagnosis depends on bronchial endoscopy and histopathology. The occurrence of plastic bronchitis in patients with status asthmaticus should be alerted.

  2. Clinical Treatment in 50 Cases of Bronchitis in Children%50例小儿支气管炎临床治疗体会

    Institute of Scientific and Technical Information of China (English)

    张楠

    2015-01-01

    目的:探讨小儿支气管炎的临床治疗方法。方法从我院收治的支气管炎患儿中随机抽取50例患儿参与本次研究,采用医学分组方法将50例支气管炎患儿分成治疗1组和治疗2组,每组25例。给予治疗1组患儿乳糖酸阿奇霉素治疗,给予治疗2组红霉素治疗。对比分析两组患儿的临床治疗效果和药物不良反应情况。结果治疗1组患儿的临床治疗总有效率和药物不良反应发生率分别为92.0%和8.0%,与治疗2组患儿的72.0%和24.0%比较差异具有统计学意义(P<0.05)。结论乳糖酸阿奇霉素治疗小儿支气管炎,临床疗效确切、可靠。%Objective To discuss the clinical treatment of children with bronchitis. Methods 50 cases of patients of bronchitis were randomly divided into two groups. The treatment 1 group was given treatment of lactobionate azithromycin. The treatment 2 group was given treatment of erythromycin. Compared the two groups of patients with clinical efficacy and adverse drug reactions. Results The treatment 1 group of children with clinical efficiency and overal incidence of adverse drug reactions was 92.0%and 8.0%,respectively,and the treatment 2 group of children with 72.0%and 24.0%and the difference was statistical y significant(P<0.05). Conclusion The treatment of children with lactose azithromycin bronchitis is reliable.

  3. 炎琥宁治疗毛细支气管炎疗效观察%Efficacy obseruatim of Dehydroandrographolide Succinate in treating capillary bronchitis

    Institute of Scientific and Technical Information of China (English)

    唐军

    2012-01-01

    Objective To analyze the therapeutic effect of Dehydroandrographolide Succinate in the treatment of capillary bronchitis. Methods 91 cases of capillary bronchitis were randomly divided into two groups: the treatment group with 52 cases and the control group with 39 cases. On the basis of the comprehensive treatment of the two groups, the control group was given intravenous ribavirin. The treatment group was treated with Dehydroandrographolide Succinate in addition with the control group. The differences in the total effective rate, the time of improvement of symptoms and physical signs between the patients of two groups were analyzed and compared. Results The total effective rate of treatment group (98.08 %) was higher than the control group (84.62 %) and the difference was statistically significant (P < 0. 05). The time when signs and symptoms such as cough, pulmonary rales and wheezing sound disappeared in treatment group were shorter than in control group, the difference was statistically significant (P < 0. 05). Conclusion The treatment of children with capillary bronchitis is more effective with additional Dehydroandrographolide Succinate.%目的 观察炎琥宁治疗毛细支气管炎的临床疗效.方法 将91例临床确诊毛细支气管炎的患儿随机分为两组,在综合治疗基础上,对照组39例加用病毒唑治疗,治疗组52例在对照组基础上加用炎琥宁,观察两组总有效率及症状、体征改善的时间并进行比较.结果 治疗组与对照组总有效率分别为98.08%和84.62%,差异具有统计学意义(P < 0.05);治疗组咳嗽、肺部啰音、肺部哮鸣音等的消失时间均明显短于对照组,差异具有统计学意义(P < 0.05).结论 炎琥宁治疗毛细支气管炎可提高疗效.

  4. 氨溴索佐治哮喘性支气管炎的临床价值%Clinical value of ambroxol in the treatment of asthmatic bronchitis

    Institute of Scientific and Technical Information of China (English)

    乔卓妮

    2012-01-01

    Objective To investigate the clinical value of ambroxol in the treatment of asthmatic bronchitis. Methods Ninety patients of asthmatic bronchitis admitted into our hospital from September 2010 to September 2011 were randomly divided into two groups, the study group (n=45) and the control group (n=45). The control group was given conventional treatment, but the study group was treated by ambroxol on the basis of conventional treatment The clinical efficacy, the disappearance time of symptoms and signs and the pulmonary function in the two groups was observed and compared after treatment Results The clinical efficacy in the study group was significantly better than that in the control group (P<0.05). The disappearance time of symptoms and signs in the study group was significantly less than those in the control group (P<0.05). The recovery of pulmonary function in the study group was significantly better than that in the control group (P<0.05). Conclusion Ambroxol had significant clinical effects in the treatment of asthmatic bronchitis.%目的 探讨氨溴索在哮喘性支气管炎治疗中的临床价值.方法 选择2010年9月至2011年9月在本院诊治的哮喘性支气管炎患者90例,将患者随机分成两组:实验组45例,对照组45例.对照组给予常规治疗,实验组则在常规治疗基础上再给予氨溴索治疗.观察两组患者的临床疗效、症状体征消失时间及其肺功能恢复情况.结果 实验组的临床疗效明显优于对照组(P<0.05);实验组症状体征消失时间明显快于对照组(P<0.05);实验组的肺功能恢复状态明显优于对照组(P<0.05).结论 临床应用氨溴索佐治哮喘性支气管炎的效果良好.

  5. Effects of erdosteine on sputum biochemical and rheologic properties: pharmacokinetics in chronic obstructive lung disease.

    Science.gov (United States)

    Marchioni, C F; Moretti, M; Muratori, M; Casadei, M C; Guerzoni, P; Scuri, R; Fregnan, G B

    1990-01-01

    Erdosteine is a new thioderivative endowed with mucokinetic, mucolytic, and free-radical-scavenging properties. This study evaluated (in a double-blind design vs. placebo) its efficacy on biochemical and rheologic properties of sputum and on some indices of respiratory function in chronic patients with chronic bronchitis (10 per group), while receiving basic treatment with a controlled-release theophylline preparation. The pharmacokinetics of erdosteine and theophylline were also studied. We found that a 2 week treatment with erdosteine (300 mg 3 times daily) was able to reduce significantly (p less than 0.05) the sputum apparent viscosity, fucose content, and macromolecular dry weight (MDW) with no statistically significant influence on sputum elasticity, DNA, albumin, total proteins, total IgA, lactoferrin, and lysozyme content. The treatment caused a significant increase in the following ratios: total IgA/albumin, lactoferrin/albumin, and lysozyme/albumin. The pharmacokinetics of erdosteine, its metabolites, and theophylline were the same after 1 or 14 days of treatment, evidence both of absence of an enzymatic induction and of an accumulation process. Further confirmation that there was no interference between erdosteine and theophylline was obtained from the data available on the group of patients receiving only theophylline, since its plasma levels and related pharmacokinetic parameters were identical to those obtained in patients receiving both drugs. In conclusion, 2 weeks of therapy with erdosteine reduced the marker of mucus glycoproteins (fucose) in patients with chronic bronchitis but did not interfere with the pharmacokinetics of xanthine derivatives. We also suggest that the significant increment in the IgA/albumin ratio might be related to a sum of other local effects such as reduction of the inflammatory process and enhancement of the humoral defense mechanism.

  6. Chronic Pancreatitis in Children

    Science.gov (United States)

    ... Information > Children/Pediatric > Chronic Pancreatitis in Children test Chronic Pancreatitis in Children What symptoms would my child ... pancreatitis will develop diabetes in adolescence. Who gets chronic pancreatitis? Those at risk for chronic pancreatitis are ...

  7. Chronic Beryllium Disease

    Science.gov (United States)

    ... Science Education & Training Home Conditions Chronic Beryllium Disease Chronic Beryllium Disease Make an Appointment Find a Doctor ... MD, MSPH, FCCP (February 01, 2016) What is chronic beryllium disease (CBD)? Chronic beryllium disease (CBD) is ...

  8. Chronic motor tic disorder

    Science.gov (United States)

    Chronic vocal tic disorder; Tic - chronic motor tic disorder ... Chronic motor tic disorder is more common than Tourette syndrome . Chronic tics may be forms of Tourette syndrome. Tics usually start ...

  9. Chronic Pelvic Pain

    Science.gov (United States)

    ... Education & Events Advocacy For Patients About ACOG Chronic Pelvic Pain Home For Patients Search FAQs Chronic Pelvic Pain ... Pelvic Pain FAQ099, August 2011 PDF Format Chronic Pelvic Pain Gynecologic Problems What is chronic pelvic pain? What ...

  10. Prevalence of chronic obstructive pulmonary disease among adult male cigarettes smokers: a community-based study in Jordan

    Directory of Open Access Journals (Sweden)

    Al Omari M

    2014-07-01

    Full Text Available Mousa Al Omari,1 Basheer Y Khassawneh,2 Yousef Khader,1 Ali Shakir Dauod,1 George Bergus3 1Department of Community Medicine, Public Health and Family Medicine, Faculty of Medicine, Jordan University of Science and Technology, 2Department of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan; 3Department of Family Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA Abstract: Chronic obstructive pulmonary disease (COPD is a leading cause of morbidity and mortality worldwide. The prevalence of COPD among cigarette smokers in the Middle East is not well studied. A prospective descriptive study was performed in the north of Jordan. Male cigarette smokers (≥10 pack-year aged 35 years and older were recruited from the community. They completed a questionnaire and a postbronchodilator spirometry. Global Initiative for Chronic Obstructive Lung Disease (GOLD criteria (postbronchodilator forced expiratory volume in 1 second <70% was used to define COPD. A total of 512 subjects completed the study protocol. According to the GOLD criteria, 42 subjects (8.2% had COPD. Of those, 27 subjects (64.3% had symptomatic COPD. Using the GOLD criteria, eight subjects (19% with COPD had mild disease, 24 (57.1% had moderate disease, eight (19% had severe disease, and two (4.8% had very severe disease. Only 10.6% were aware of COPD as a smoking-related respiratory illness, and 6.4% had received counseling about risk for COPD by a physician. Chronic bronchitis (cough for 3 months in 2 consecutive years was reported by 15% of the subjects, wheezes by 44.1%, and dyspnea by 65.2%. Subjects with COPD reported having more chronic bronchitis 18/42 (42.9% and wheezing 28/42 (66.7% than subjects without COPD. The prevalence of COPD increased with increased number of pack-years smoked. In conclusion, COPD prevalence among cigarette-smoking men in Jordan is lower than in the developed world. COPD was largely

  11. Chronic thyroiditis (Hashimoto disease)

    Science.gov (United States)

    Hashimoto thyroiditis; Chronic lymphocytic thyroiditis; Autoimmune thyroiditis; Chronic autoimmune thyroiditis; Lymphadenoid goiter - Hashimoto; Hypothyroidism - Hashimoto; Type 2 polyglandular autoimmune ...

  12. Prevalence of Newcastle disease virus and infectious bronchitis virus in avian influenza negative birds from live bird markets and backyard and commercial farms in Ivory-Coast.

    Science.gov (United States)

    Kouakou, A V; Kouakou, V; Kouakou, C; Godji, P; Kouassi, A L; Krou, H A; Langeois, Q; Webby, R J; Ducatez, M F; Couacy-Hymann, E

    2015-10-01

    Newcastle disease (ND) and infectious bronchitis (IB) are two major viral diseases affecting the respiratory tracts of birds and whose impact on African poultry is still poorly known. In the present study we aimed at assessing NDV and IBV prevalences in Ivory-Coast by molecular screening of >22,000 avian swabs by nested PCR and by serology testing of close to 2000 avian sera from 2010 through 2012. The NDV and IBV seroprevalences over the study period reached 22% and 72%, respectively. We found 14.7% pooled swabs positive by PCR for NDV and 14.6% for IBV. Both pathogens are therefore endemic in Ivory-Coast. Economic losses associated with NDV and IBV infections still need to be evaluated.

  13. Advances in the diagnosis and treatment of children with plastic bronchitis%儿童塑型性支气管炎诊疗进展

    Institute of Scientific and Technical Information of China (English)

    张雪

    2013-01-01

    儿童塑型性支气管炎是一种较罕见的疾病,病因不明,起病隐匿,进展快,症状重,诊断和治疗难度大,病死率高.儿童塑型支气管炎被认为与某些疾病包括支气管哮喘、囊性纤维病、伴发急性胸部综合征的镰状细胞病、先天性心脏病以及各种呼吸道细菌性和病毒性感染有一定关系.关于儿童塑型性支气管炎的诊断和治疗目前仍较困难,临床医生应该警惕该病,做到早期诊断、早期治疗.%Children with plastic bronchitis,characterized by unknown origin,insidious onset,rapid progress,severe symptom and high mortality,is a relatively rare disease.Also,it is difficult to diagnose and treat with plastic bronchitis characterized by marked airway obstruction,via the formation of large gelatinous or rigid airway cast.It is associated with certain diseases including bronchial asthma,cystic fibrosis,accompanied with acute chest syndrome with sickle cell disease,congenital heart disease and bacterial and viral respiratory infection.Clinicians should be aware of this disease,and early bronchoscopy should be intervened.

  14. Immunohistochemistry for detection of avian infectious bronchitis virus strain M41 in the proventriculus and nervous system of experimentally infected chicken embryos

    Directory of Open Access Journals (Sweden)

    Keil Günther M

    2009-02-01

    Full Text Available Abstract Background Infectious bronchitis virus primarily induces a disease of the respiratory system, different IBV strains may show variable tissue tropisms and also affect the oviduct and the kidneys. Proventriculitis was also associated with some new IBV strains. Aim of this study was to investigate by immunohistochemistry (IHC the tissue tropism of avian infectious bronchitis virus (IBV strain M41 in experimentally infected chicken embryos. Results To this end chicken embryos were inoculated in the allantoic sac with 103 EID50 of IBV M41 at 10 days of age. At 48, 72, and 120 h postinoculation (PI, embryos and chorioallantoic membranes (CAM were sampled, fixed, and paraffin-wax embedded. Allantoic fluid was also collected and titrated in chicken embryo kidney cells (CEK. The sensitivity of IHC in detecting IBV antigens in the CAM of inoculated eggs matched the virus reisolation and detection in CEK. Using IHC, antigens of IBV were detected in nasal epithelium, trachea, lung, spleen, myocardial vasculature, liver, gastrointestinal tract, kidney, skin, sclera of the eye, spinal cord, as well as in brain neurons of the inoculated embryos. These results were consistent with virus isolation and denote the wide tissue tropism of IBV M41 in the chicken embryo. Most importantly, we found infection of vasculature and smooth muscle of the proventriculus which has not seen before with IBV strain M41. Conclusion IHC can be an additional useful tool for diagnosis of IBV infection in chickens and allows further studies to foster a deeper understanding of the pathogenesis of infections with IBV strains of different virulence. Moreover, these results underline that embryonic tissues in addition to CAM could be also used as possible source to generate IBV antigens for diagnostic purposes.

  15. Chronic Obstructive Pulmonary Disease; Jeg faar ikke puste!

    Energy Technology Data Exchange (ETDEWEB)

    Smith-Sivertsen, Eline Randers

    2004-07-01

    Many people are struggling with work-related asthma every day, which may lead to COPD, Chronic Obstructive Pulmonary Disease. COPD may be caused by illnesses like chronic bronchitis, emphysema, asthma. In serious cases of COPD, the breathing resistance has increased considerably and those suffering from it are breathing heavily. Asthma can be linked with working conditions in many ways. Exertion, cold air, and some chemical substances like sulphur dioxide can start asthma attacks. The results of early treatment or prophylactic treatment of asthma are good, but COPD is much more difficult. Although smoking is the most important cause of COPD, people who have been working for many years in highly polluted environments run a higher risk of contracting COPD. However, little is known about which specific substances are causing the disease. Particularly at risk are bakers, industrial painters, and people working in electrolysis halls in the aluminium industry. There is no effective medical treatment for COPD once the lungs have been damaged, but many hospitals offer rehabilitation.

  16. Diagnostic values of electrocardiogram in chronic obstructive pulmonary disease (COPD

    Directory of Open Access Journals (Sweden)

    Agarwal R

    2008-01-01

    Full Text Available Background : Chronic obstructive pulmonary diseases (COPD, a broad spectrum of respiratory diseases represents a worldwide problem. Electrocardiographic (ECG findings may help in clinical decision making regarding this disease entity. Aims: To evaluate the extent and diagnostic values of ECG changes among COPD patients suffering from broad spectrum of respiratory diseases. Material & Methods : A hos-pital based cross-sectional study was conducted in Sworoop Rani Nehru Hospital, Allahabad in Eastern Uttar Pradesh (UP, India. A sample of 60 patients attending respiratory diseases OPD for treatment of various respiratory problems including 14 COPD patients was selected randomly during 2000-2001. Patients of respiratory diseases were also evaluated electrocardiographically along with other investiga-tions. Results : Respiratory problems were more common among rural males of low socio-economic group. COPD particularly chronic bronchitis was the commonest respiratory problem next to pulmonary tuberculosis. Inspite of normal heart rate observed in 71.4% COPD patients, ECG changes were present in 35.7% COPD patients. Peaked P-wave was observed in 35.7% COPD patients, whereas duration of QRS complex was abnormal in only 8.1% of the patients. None of the COPD patients showed abnormal P-wave duration. ECG changes were found less sensitive (35.7% but highly specific (95.6%. Conclusion : Diagnostic values of ECG among patients with respiratory problems suggest that COPD patients should be screened electrocardiographically in addition to other clinical investigations.

  17. Hospital contacts for chronic diseases among danish seafarers and fishermen: a population-based cohort study

    DEFF Research Database (Denmark)

    Kaerlev, Linda; Dahl, Søren; Nielsen, Per Sabro

    2007-01-01

    and the SHCR for chronic heart diseases was statistically significantly higher in the 1999 than in the 1994 cohort. For both time periods high SHCR values were found for bronchitis, emphysema, cancer of the lung, alcohol-related liver diseases, and diabetes among male non-officers, and lung cancer among male...... Danish seafarers (officers and non-officers) registered by the Danish Maritime Authority (DMA) 1989-98 and fishermen retrieved from a pension registry 1989-98 were linked to the nationwide Occupational Hospitalization Registry (OHR) and followed up for incident diseases in two five-year time periods......, from 1 January 1994 and 1 January 1999, respectively, using rates specific for age and calendar time for the entire Danish workforce as a reference. RESULTS: The SHCRs for lung and cardiovascular diseases were high for non-officers. Among male officers, the SHCR for diabetes was high in the 1999 cohort...

  18. Nursing countermeasures of children with bronchitis complicated with heart failure%小儿支气管炎合并心力衰竭的护理对策探讨

    Institute of Scientific and Technical Information of China (English)

    王玲

    2015-01-01

    Objective To explore the infantile bronchitis combined heart failure patient care value. MethodTo select merger of 60 patients with heart failure, the child bronchitis were randomly divided into 2 groups, 30 cases of experimental group patients received comprehensive nursing, 30 cases of control group patients received basic care, compared two groups merge the child bronchitis the effect of heart failure patient care. ResultsThe experimental group of pediatric patients with the comprehensive nursing basic nursing is obviously better than the total effective rate of control group (P < 0.05). ConclusionInfantile bronchitis combined heart failure patient received effective nursing intervention, can improve the effect of treatment of pediatric patients.%目的:探究小儿支气管炎合并心力衰竭患者的护理价值.方法:选取小儿支气管炎合并心力衰竭患者60例,随机分为2组,30例实验组患者接受综合护理,30例对照组患者接受基本护理,对比2组小儿支气管炎合并心力衰竭患者护理的效果.结果:实验组小儿患者经综合护理的总有效率明显优于基本护理的对照组(P<0.05).结论:小儿支气管炎合并心力衰竭患者接受有效的护理干预,可以提高小儿患者治疗的效果.

  19. Chronic inflammatory demyelinating polyneuropathy

    Science.gov (United States)

    Polyneuropathy - chronic inflammatory; CIDP; Chronic inflammatory polyneuropathy; Guillain-Barré - CIDP ... Health care providers also consider CIDP as the chronic form of Guillain-Barré syndrome. The specific triggers ...

  20. Dealing with chronic cancer

    Science.gov (United States)

    ... medlineplus.gov/ency/patientinstructions/000933.htm Dealing with chronic cancer To use the sharing features on this ... be controlled for a period of time. Controlling Chronic Cancer When you have a chronic cancer, the ...

  1. Clinical Observation on Treatment of Pediatric Bronchitis of Blood-stasis Patten with Pollen Formula%花粉配方治疗小儿瘀血型支气管炎的临床观察

    Institute of Scientific and Technical Information of China (English)

    刘昌建

    2008-01-01

    Objective To observe the effect of treating pediatric blood-stasis pattern bronchitis with pollen formula.Methods 260 cases of blood-stasis pattern bronchitis was randomly recruited into a treatment group(200 eases)and a control group(60 cases).The treatment group was treated with pollen formula,and the control group was treated with Benzylpenicillin intramuscularly and Ketelin OP.Both groups were treated for a therapeutic coarse of 3 days.Results The therapeutic effect of the treatment group and the control group was 96%and 89.9%respectively.Conclusion Pollen formula was effective in treating pediatric blood-stasis pattern bronchitis.%目的 观察花粉配方治疗小儿瘀血犁支气管炎的临床疗效.方法 将260例小儿瘀血型支气管炎分为治疗组200例和对照组60例,治疗组采用花粉配方,对照组肌注青霉素和口服咳特灵,两组均3 d为1个疗程.结果 治疗组总有效率为96%,对照组总有效率为89.9%.结论 花粉配方治疗瘀血型支气管炎有效.

  2. Chronic mucus hypersecretion

    DEFF Research Database (Denmark)

    Harmsen, L; Thomsen, S F; Sylvan Ingebrigtsen, Truls;

    2010-01-01

    Chronic mucus hypersecretion (CMH) is a common condition in patients with chronic respiratory diseases. Little is known about the incidence, prevalence and determinants of CMH in younger individuals....

  3. Occupation, smoking, and chronic obstructive respiratory disorders: a cross sectional study in an industrial area of Catalonia, Spain

    Directory of Open Access Journals (Sweden)

    Kogevinas Manolis

    2006-02-01

    Full Text Available Abstract Background Few studies have investigated the independent effects of occupational exposures and smoking on chronic bronchitis and airflow obstruction. We assessed the association between lifetime occupational exposures and airflow obstruction in a cross-sectional survey in an urban-industrial area of Catalonia, Spain. Methods We interviewed 576 subjects of both sexes aged 20–70 years (response rate 80% randomly selected from census rolls, using the ATS questionnaire. Forced spirometry was performed by 497 subjects according to ATS normative. Results Lifetime occupational exposure to dust, gases or fumes was reported by 52% of the subjects (63% in men, 41% in women. Textile industry was the most frequently reported job in relation to these exposures (39%. Chronic cough, expectoration and wheeze were more prevalent in exposed subjects with odds ratios ranging from 1.7 to 2.0 being highest among never-smokers (2.1 to 4.3. Lung function differences between exposed and unexposed subjects were dependent on duration of exposure, but not on smoking habits. Subjects exposed more than 15 years to dusts, gases or fumes had lower lung function values (FEV1 -80 ml, 95% confidence interval (CI -186 to 26; MMEF -163 ml, CI -397 to 71; FEV1/FVC ratio -1.7%, CI -3.3 to -0.2 than non-exposed. Conclusion Chronic bronchitis symptoms and airflow obstruction are associated with occupational exposures in a population with a high employment in the textile industry. Lung function impairment was related to the duration of occupational exposure, being independent of the effect of smoking.

  4. Chronic urticaria

    Directory of Open Access Journals (Sweden)

    Sandeep Sachdeva

    2011-01-01

    Full Text Available Chronic urticaria (CU is a disturbing allergic condition of the skin. Although frequently benign, it may sometimes be a red flag sign of a serious internal disease. A multitude of etiologies have been implicated in the causation of CU, including physical, infective, vasculitic, psychological and idiopathic. An autoimmune basis of most of the ′idiopathic′ forms is now hypothesized. Histamine released from mast cells is the major effector in pathogenesis and it is clinically characterized by wheals that have a tendency to recur. Laboratory investigations aimed at a specific etiology are not always conclusive, though may be suggestive of an underlying condition. A clinical search for associated systemic disease is strongly advocated under appropriate circumstances. The mainstay of treatment remains H1 antihistaminics. These may be combined with complementary pharmacopeia in the form of H2 blockers, doxepin, nifedipine and leukotriene inhibitors. More radical therapy in the form of immunoglobulins, plasmapheresis and cyclophosphamide may be required for recalcitrant cases. Autologous transfusion and alternative remedies like acupuncture have prospects for future. A stepwise management results in favorable outcomes. An update on CU based on our experience with patients at a tertiary care centre is presented.

  5. Eggshell apex abnormalities in a free-range hen farm with mycoplasma synoviae and infectious bronchitis virus in Rio de Janeiro state, Brazil

    Directory of Open Access Journals (Sweden)

    FC dos Santos

    2014-06-01

    Full Text Available A farm with 3,000 free-range hens between 24 and 65 weeks of age was investigated. These hens were separated in small flocks of 400 to 700 birds, presenting 10 to 23% egg production reduction. Twenty serum samples were collected during the period of drop in egg production and three weeks later for the investigation of Mycoplasma synoviae (MS, M. gallisepticum (MG and Infectious Bronchitis Virus (IBV antibodies using ELISA. At the time of the second collection, egg production had resumed to normal levels; however, with 10.23% of the eggs showed eggshell abnormalities limited to the apex. Eggshell strength was significantly different between normal and those with eggshell apex abnormalities, but not other egg-quality parameters. ELISA tests showed that MS and IBV titers increased during the evaluated period. MS infection was confirmed by culture and by PCR of tracheal swabs. All samples were negative for MG by ELISA and PCR. Further studies with larger samples to ensure the occurrence of this disease in industrial layer flocks in Brazil are under way.

  6. Successful cross-protective efficacy induced by heat-adapted live attenuated nephropathogenic infectious bronchitis virus derived from a natural recombinant strain.

    Science.gov (United States)

    Lim, Tae-Hyun; Youn, Ha-Na; Yuk, Seong-Su; Kwon, Jung-Hoon; Hong, Woo-Tack; Gwon, Gyeong-Bin; Lee, Jung-Ah; Lee, Joong-Bok; Lee, Sang-Won; Song, Chang-Seon

    2015-12-16

    A natural recombinant nephropathogenic K40/09 strain of infectious bronchitis virus (IBV) was heat-adapted for possible future use as live attenuated vaccine. The K40/09 strain was selected during successive serial passages in specific-pathogen free (SPF) embryonated eggs at sub-optimal higher temperature (56°C). Unlike the parental strain, the attenuated strain, designated K40/09 HP50, was found to be safe in 1-day-old SPF chicks, which showed neither mortality nor signs of morbidity, and rarely induced ciliostasis or histological changes in the trachea and kidney after intraocular and fine-spray administration. K40/09 HP50 provided almost complete protection against two distinct subgroups of a nephropathogenic strain (KM91-like and QX-like subgroup) and elicited the production of high titers of neutralizing antibody (neutralization index of 3.6). We conclude that the K40/09 HP50 vaccine virus is rapidly attenuated by heat adaptation and exhibits the desired level of attenuation, immunogenicity, and protective efficacy required for a live attenuated vaccine. These results indicate that the K40/09 vaccine could be helpful for the reduction of economic losses caused by recently emergent nephropathogenic IBV infection in many countries.

  7. The Important Role of Lipid Raft-Mediated Attachment in the Infection of Cultured Cells by Coronavirus Infectious Bronchitis Virus Beaudette Strain

    Science.gov (United States)

    Guo, Huichen; Huang, Mei; Yuan, Quan; Wei, Yanquan; Gao, Yuan; Mao, Lejiao; Gu, Lingjun; Tan, Yong Wah; Zhong, Yanxin; Liu, Dingxiang; Sun, Shiqi

    2017-01-01

    Lipid raft is an important element for the cellular entry of some viruses, including coronavirus infectious bronchitis virus (IBV). However, the exact role of lipid rafts in the cellular membrane during the entry of IBV into host cells is still unknown. In this study, we biochemically fractionated IBV-infected cells via sucrose density gradient centrifugation after depleting plasma membrane cholesterol with methyl-β-cyclodextrin or Mevastatin. Our results demonstrated that unlike IBV non-structural proteins, IBV structural proteins co-localized with lipid raft marker caveolin-1. Infectivity assay results of Vero cells illustrated that the drug-induced disruption of lipid rafts significantly suppressed IBV infection. Further studies revealed that lipid rafts were not required for IBV genome replication or virion release at later stages. However, the drug-mediated depletion of lipid rafts in Vero cells before IBV attachment significantly reduced the expression of viral structural proteins, suggesting that drug treatment impaired the attachment of IBV to the cell surface. Our results indicated that lipid rafts serve as attachment factors during the early stages of IBV infection, especially during the attachment stage. PMID:28081264

  8. Isolation and molecular characterization of infectious bronchitis virus from recent outbreaks in broiler flocks reveals emergence of novel strain in India.

    Science.gov (United States)

    Sumi, Vikshe; Singh, Shambhu Dayal; Dhama, Kuldeep; Gowthaman, Vasudevan; Barathidasan, Rajamani; Sukumar, Kuppannan

    2012-10-01

    In this study, two isolates of infectious bronchitis virus (IBV) from field outbreaks in 2008 (India/LKW/56/IVRI/08) and 2010 (India/NMK/72/IVRI/10) from broiler chickens in India were isolated and characterized. Reverse transcription polymerase chain reaction-restriction fragment length polymorphism of the entire S1 gene revealed that these isolates belong to two different genotypes, India/LKW/56/IVRI/08 as Mass strain whereas India/NMK/72/IVRI/10 as of different genotype. Nucleotide sequencing analysis showed that India/LKW/56/IVRI/08 shared 99 % homology with THA280252 (Thailand) and India/NMK/72/IVRI/10 shared greater than 99 % homology with 4/91 pathogenic strain (UK), JP/Wakayama/2/2004 (Japan) and TA03 (China), while the two Indian IBV isolates shared 73 % identity between them. Phylogenetic data allowed classification of two Indian isolates, India/LKW/56/IVRI/08 as having unique lineage within Mass genotype and India/NMK/72/IVRI/10 as of 4/91 genotype. Our study confirmed the presence of 4/91 (793/B) IBV nephropathogenic strain for the first time in India by virus isolation and sequencing.

  9. [Pelargonium sidoides in acute bronchitis - Health-related quality of life and patient-reported outcome in adults receiving EPs 7630 treatment].

    Science.gov (United States)

    Matthys, Heinrich; Lizogub, Victor G; Funk, Petra; Malek, Fathi A

    2010-12-01

    Health-related quality of life (HRQL) and patient-reported outcome (PRO) have become important outcome parameters for the evaluation of medical treatment within clinical trials and, furthermore, to evaluate efficiency in clinical practice. We therefore report further exploratory results of an already reported dose-finding study with EPs 7630 tablets, now focussing on HRQL and PRO. A total of 406 adults with acute bronchitis were randomly assigned to one of four parallel treatment groups (placebo, 30 mg, 60 mg or 90 mg EPs 7630 daily). HRQL and PRO were assessed by questionnaires as secondary outcome measures at each study visit or daily in the patient's diary. At day 7, the patient-reported outcome measures were significantly more improved in all the three EPs 7630 groups compared to placebo (EQ-5D and EQ VAS, SF-12: physical score, impact of patient's sickness, duration of activity limitation, patient-reported treatment outcome, satisfaction with treatment). In conclusion, a statistically significant and clinically relevant improvement of HRQL/PRO compared to placebo was shown in all the three EPs 7630 groups.

  10. Inhaler use in adolescents and adults with self-reported physician-diagnosed asthma, bronchitis, or emphysema in the city of Pelotas, Brazil

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    Paula Duarte de Oliveira

    2013-06-01

    Full Text Available OBJECTIVE: To evaluate the characteristics of users of inhalers and the prevalence of inhaler use among adolescents and adults with self-reported physician-diagnosed asthma, bronchitis, or emphysema. METHODS: A population-based study conducted in the city of Pelotas, Brazil, involving 3,670 subjects ≥ 10 years of age, evaluated with a questionnaire. RESULTS: Approximately 10% of the sample reported at least one of the respiratory diseases studied. Among those individuals, 59% reported respiratory symptoms in the last year, and, of those, only half reported using inhalers. The use of inhalers differed significantly by socioeconomic status (39% and 61% for the lowest and the highest, respectively, p = 0.01. The frequency of inhaler use did not differ by gender or age. Among the individuals reporting emphysema and inhaler use, the use of the bronchodilator-corticosteroid combination was more common than was that of a bronchodilator alone. Only among the individuals reporting physician-diagnosed asthma and current symptoms was the proportion of inhaler users higher than 50%. CONCLUSIONS: In our sample, inhalers were underutilized, and the type of medication used by the individuals who reported emphysema does not seem to be in accordance with the consensus recommendations.

  11. Microwave or autoclave treatments destroy the infectivity of infectious bronchitis virus and avian pneumovirus but allow detection by reverse transcriptase-polymerase chain reaction.

    Science.gov (United States)

    Elhafi, G; Naylor, C J; Savage, C E; Jones, R C

    2004-06-01

    A method is described for enabling safe transit of denatured virus samples for polymerase chain reaction (PCR) identification without the risk of unwanted viable viruses. Cotton swabs dipped in avian infectious bronchitis virus (IBV) or avian pneumovirus (APV) were allowed to dry. Newcastle disease virus and avian influenza viruses were used as controls. Autoclaving and microwave treatment for as little as 20 sec destroyed the infectivity of all four viruses. However, both IBV and APV could be detected by reverse transcriptase (RT)-PCR after autoclaving and as long as 5 min microwave treatment (Newcastle disease virus and avian influenza viruses were not tested). Double microwave treatment of IBV and APV with an interval of 2 to 7 days between was tested. After the second treatment, RT-PCR products were readily detected in all samples. Swabs from the tracheas and cloacas of chicks infected with IBV shown to contain infectious virus were microwaved. Swabs from both sources were positive by RT-PCR. Microwave treatment appears to be a satisfactory method of inactivating virus while preserving nucleic acid for PCR identification.

  12. Evaluation of a novel strain of infectious bronchitis virus emerged as a result of spike gene recombination between two highly diverged parent strains.

    Science.gov (United States)

    Hewson, Kylie A; Noormohammadi, Amir H; Devlin, Joanne M; Browning, Glenn F; Schultz, Bridie K; Ignjatovic, Jagoda

    2014-01-01

    The emergence of new variant strains of the poultry pathogen infectious bronchitis virus (IBV) is continually reported worldwide, owing to the labile nature of the large single-stranded RNA IBV genome. High resolution melt curve analysis previously detected a variant strain, N1/08, and the present study confirmed that this strain had emerged as a result of recombination between Australian subgroup 2 and 3 strains in the spike gene region, in a similar manner reported for turkey coronaviruses. The S1 gene for N1/08 had highest nucleotide similarity with subgroup 2 strains, which is interesting considering subgroup 2 strains have not been detected since the early 1990s. SimPlot analysis of the 7.2-kb 3' end of the N1/08 genome with the same region for other Australian reference strains identified the sites of recombination as immediately upstream and downstream of the S1 gene. A pathogenicity study in 2-week-old chickens found that N1/08 had similar pathogenicity for chicken respiratory tissues to that reported for subgroup 2 strains rather than subgroup 3 strains. The results of this study demonstrate that recombination is a mechanism utilized for the emergence of new strains of IBV, with the ability to alter strain pathogenicity in a single generation.

  13. Rapid detection and non-subjective characterisation of infectious bronchitis virus isolates using high-resolution melt curve analysis and a mathematical model.

    Science.gov (United States)

    Hewson, Kylie; Noormohammadi, Amir H; Devlin, Joanne M; Mardani, Karim; Ignjatovic, Jagoda

    2009-01-01

    Infectious bronchitis virus (IBV) is a coronavirus that causes upper respiratory, renal and/or reproductive diseases with high morbidity in poultry. Classification of IBV is important for implementation of vaccination strategies to control the disease in commercial poultry. Currently, the lengthy process of sequence analysis of the IBV S1 gene is considered the gold standard for IBV strain identification, with a high nucleotide identity (e.g. > or =95%) indicating related strains. However, this gene has a high propensity to mutate and/or undergo recombination, and alone it may not be reliable for strain identification. A real-time polymerase chain reaction (RT-PCR) combined with high-resolution melt (HRM) curve analysis was developed based on the 3'UTR of IBV for rapid detection and classification of IBV from commercial poultry. HRM curves generated from 230 to 435-bp PCR products of several IBV strains were subjected to further analysis using a mathematical model also developed during this study. It was shown that a combination of HRM curve analysis and the mathematical model could reliably group 189 out of 190 comparisons of pairs of IBV strains in accordance with their 3'UTR and S1 gene identities. The newly developed RT-PCR/HRM curve analysis model could detect and rapidly identify novel and vaccine-related IBV strains, as confirmed by S1 gene and 3'UTR nucleotide sequences. This model is a rapid, reliable, accurate and non-subjective system for detection of IBVs in poultry flocks.

  14. The detection of infectious bronchitis viral antigen by means of immunohistochemical technique in broiler chicken infected with I-269 IB isolate or injected with H-120 live vaccine

    Directory of Open Access Journals (Sweden)

    Rini Damayanti

    2001-12-01

    Full Text Available A study was carried out to detect the antigen of infectious bronchitis vius (IBV in broiler chicken by means of immunohistochemical technique. A total of 150 - fourteen days old broiler chicken were divided into three groups i.e. 50 chicken were infected with an IB isolate of I-269, 50 chicken were injected with H-120 life vaccine, and 50 chicken served as un-treated control. Clinical signs and gross pathological changes were observed. Each of five chicken of each group were necropsied at 1, 2, 3, 4, 7, 10, 14, 21, 28, and 35 day(s post infection/vaccination. The antigen could be detected at one day through 35 days post vaccination/infection. In the vaccinated group, histopathological lesions and the detected antigen were minimal. In contrast, the infected chicken showed varied histolopathological lesion in accordance with the numerous antigens. The antigen were observed in the lymphocytes/macrophages in the trachea, lungs and kidney, and in the epithelium of trachea, alveoli, broncheolus and tubular sitoplasm of the kidney of both vaccinated and infected groups. In the infected group, antigen was also detected in the lymphocytes and macrophages of the affected organs.

  15. Discrepancy between presumptive and definite causes of chronic cough

    Institute of Scientific and Technical Information of China (English)

    YU Li; QIU Zhi-hong; WEI Wei-li; LIU Bo; XU Xiang-huai; L(U) Han-jing; QIU Zhong-min

    2011-01-01

    Background The current diagnostic algorithms for chronic cough require the establishment of the primary presumptive causes followed by the confirmation of diagnosis with the specific therapies.The aim of the study was to investigate the discrepancy between presumptive and definite causes and its clinical implication.Methods A total of 109 patients with chronic cough underwent laboratory investigations to identify the cause of cough; including sinus computerized tomography (if needed),histamine bronchial provocation,induced sputum cytology and 24-hour esophageal pH or multi-channel intraluminal impedance combined with pH monitoring.The presumptive causes were confirmed by treating them sequentially.The difference between presumptive and definite causes of chronic cough was compared.Results Single cause was more frequent in the definite diagnosis than in the presumptive diagnosis (78.9% vs.54.1%,x2=15.01,P=0.0001).In contrast,multiple causes were significantly fewer in definite diagnosis than in the presumptive diagnosis (15.6% vs.37.6%,x2=13.53,P=0.0002).There was a discrepancy between definite and presumptive causes in 30 patients (27.5%).Compared with the presumptive causes,definite upper airway cough syndrome (24.8% vs.11.9%,x2=6.0,P=0.01) and gastroesophageal reflux disease (6.4% vs.0,x2=7.23,P=0.007) was more frequent as a single cause of chronic cough while cough variant asthma plus gastroesophageal reflux disease (3.7% vs.11.9%,x2=5.17,P=0.02) and upper airway cough syndrome plus nonasthmatic eosinophilic bronchitis (0 vs.9.2%,x2=10.48,P=0.001) were fewer as multiple causes of chronic cough.Conclusions A discrepancy was common between presumptive and definite causes of chronic cough.To treat presumptive causes sequentially may be a suitable solution for avoidance of erroneous multiple causes and possible over-treatment.

  16. Chronic pain after hysterectomy

    DEFF Research Database (Denmark)

    Brandsborg, B.; Nikolajsen, L.; Kehlet, H.;

    2008-01-01

    BACKGROUND: Chronic pain is a well-known adverse effect of surgery, but the risk of chronic pain after gynaecological surgery is less established. METHOD: This review summarizes studies on chronic pain following hysterectomy. The underlying mechanisms and risk factors for the development of chronic...... post-hysterectomy pain are discussed. RESULTS AND CONCLUSION: Chronic pain is reported by 5-32% of women after hysterectomy. A guideline is proposed for future prospective studies Udgivelsesdato: 2008/3...

  17. Chronic pain after hysterectomy

    DEFF Research Database (Denmark)

    Brandsborg, B; Nikolajsen, L; Kehlet, Henrik;

    2008-01-01

    BACKGROUND: Chronic pain is a well-known adverse effect of surgery, but the risk of chronic pain after gynaecological surgery is less established. METHOD: This review summarizes studies on chronic pain following hysterectomy. The underlying mechanisms and risk factors for the development of chronic...... post-hysterectomy pain are discussed. RESULTS AND CONCLUSION: Chronic pain is reported by 5-32% of women after hysterectomy. A guideline is proposed for future prospective studies. Udgivelsesdato: 2008-Mar...

  18. Past, present and future of macrolide therapy for chronic rhinosinusitis in Japan.

    Science.gov (United States)

    Shimizu, Takeshi; Suzaki, Harumi

    2016-04-01

    In 1984, the effectiveness of low-dose, long-term erythromycin treatment (macrolide therapy) for diffuse panbronchiolitis (DPB) was first reported in Japan. The 5-year survival rate for DPB improved from 62.9 to 91.4% after implementation of macrolide therapy. The usefulness of this treatment has since been demonstrated in patients with other chronic airway diseases, such as chronic bronchitis, cystic fibrosis, bronchiectasis, bronchial asthma, and chronic rhinosinusitis (CRS). The new 14-membered macrolides clarithromycin and roxithromycin and the 15-membered macrolide azithromycin are also effective for treating these inflammatory diseases. The mechanism of action of the 14- and 15-membered macrolides may involve anti-inflammatory rather than anti-bacterial activities. Macrolide therapy is now widely used for the treatment of CRS in Japan; it is particularly effective for treating neutrophil-associated CRS and is useful for suppressing mucus hypersecretion. However, macrolide therapy is not effective for eosinophil-predominant CRS, which is characterized by serum and tissue eosinophilia, high serum IgE levels, multiple polyposis, and bronchial asthma. Recent reports have described the clinical efficacy of macrolides in treating other inflammatory diseases and new biological activities (e.g., anti-viral). New macrolide derivatives exhibiting anti-inflammatory but not anti-bacterial activity thus have therapeutic potential as immunomodulatory drugs. The history, current state, and future perspectives of macrolide therapy for treating CRS in Japan will be discussed in this review.

  19. VOICE RELATED QUALITY OF LIFE IN INDIVIDUALS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

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    Anuradha Shastry, Radish Kumar B, Preetham Acharya R

    2015-01-01

    Full Text Available Background: Chronic Obstructive Pulmonary Disease (COPD refers to lung diseases such as, Chronic Bronchitis, Chronic Asthma and Emphysema. These diseases are characterized by obstruction to airflow that interferes with normal breathing and they frequently co-exist. COPD can affect voice as respiration is a vital subsystem for voice production COPD that have a significant voice impairment which might further impact the quality of life. There are very few studies available in the voice literature on the assessment of quality of life in individuals with COPD. In this regard, the study aimed to assess the voice related quality of life in individuals with COPD and compare the findings with normal controls. Methods:64 participants were considered for this present study under two groups (Group 1: individuals with COPD, Group 2: normal individuals. The voice disorder outcome profile (Voice-DOP, self-perceived severity of voice problem rating scale and the modified medical research council (MMRC dyspnoea scale were the quality of life measures employed in this study. Results: There was statistically significant difference between the two groups on all the three measures at p < 0.05. Further, a positive correlation was found between all the three measures. Conclusions: These findings indicate that COPD has an impact on the individual’s quality of life. This could be attributed to the voice deviations due to COPD itself or due to the effects of the medication that cause an impact the voice related quality of life in these individuals.

  20. Association between chronic obstructive pulmonary disease and lung cancer: a case-control study in Southern Chinese and a meta-analysis.

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    Hui Wang

    Full Text Available BACKGROUND: Lung cancer and chronic obstructive pulmonary disease (COPD share a common risk factor in cigarette smoking and a large portion of patients with lung cancer suffer from COPD synchronously. We therefore hypothesized that COPD is an independent risk factor for lung cancer. Our aim was to investigate the intrinsic linkage of COPD (or emphysema, chronic bronchitis and asthma and lung cancer. METHODS: The present hospital-based case-control study included 1,069 patients with newly diagnosed lung cancer and 1,132 age frequency matched cancer-free controls. The odds ratios (ORs for the associations between each previous pulmonary disease and lung cancer were estimated with logistic regression models, adjusting for age, sex, family history of cancer, BMI and pack year smoking. In meta-analysis, the pooled effects of previous pulmonary diseases were analyzed with random effects models; and stratification analyses were conducted on smoking status and ethnicity. RESULTS: In the case-control study, previous COPD was associated with the odds for increased risk of lung cancer (OR = 1.29, 95% confidence interval [CI] = 1.00∼1.68; so were emphysema (OR = 1.55, 95%CI = 1.03∼2.32 and chronic bronchitis (OR = 1.22, 95%CI = 0.99∼1.67; while asthma was associated with odds for decreased risk of lung cancer (OR = 0.29, 95%CI = 0.16∼0.53. These associations were more pronounced in smokers (P<.05 for all strata, but not in non-smokers. In meta-analysis, 35 studies (22,010 cases and 44,438 controls were identified. COPD was significantly associated with the odds for increased risk of lung cancer (pooled OR = 2.76; 95% CI = 1.85-4.11, so were emphysema (OR = 3.02; 95% CI = 2.41-3.79 and chronic bronchitis (OR = 1.88; 95% CI = 1.49-2.36; and these associations were more pronounced in smokers than in non-smokers (P<.001 respectively. No significant association was observed for asthma. CONCLUSION: Previous COPD could increase the risk of lung cancer

  1. [Chronic otitis mediaChronic Otitis Media].

    Science.gov (United States)

    Kohles, N; Schulz, T; Eßer, D

    2015-11-01

    There are 2 different kinds of chronic otitis media: Otitis media chronica mesotympanalis and otitis media chronica epitympanalis (cholesteatoma). The incidence of chronic otitis media as reported in literature differs in a wide range. The incidence rates vary between 0.45 and 46%. Both, otitis media chronica mesotympanalis and cholesteatoma, lead to eardrum perforation due to lengthy and recurring inflammations. Furthermore, chronic otitis media is characterized by frequently recurring otorrhea and conductive hearing loss.

  2. A STUDY OF CLINICAL PROFILE, RADIOLOGICAL FEATURES, ELECTROCARDIOGRAPHIC AND ECHOCARDIOGRAPHIC CHANGES IN CHRONIC COR PULMONALE IN A RURAL HOSPITAL

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    Sunil Babu

    2013-11-01

    Full Text Available ABSTRACT: BACKGROUND AND OBJECTIVES: To study the clinical profile, radiological features, electrocardiographic and echocardiographic changes in clinically proven cases of chronic cor pulmonale. METHODS: 50 patients who were diagnosed to have chronic cor pulmonale based on the inclusion criteria were selected from the medical wards of Adichunchanagiri Hospital and research centre, over a period of 2 years In all the selected patients detailed history and physical examination was noted and chest x - ray PA, 1 2 lead ECG and echocardiogram done. RESULTS: Among 50 patients admitted with chronic cor pulmonale, 45 were males and 5 were females. The peak incidence was found in the 4 th , 5 th and 6 th decades of life. Smoking was found to be a major cause for COPD and h ence cor pulmonale. Among 50 patients 43 were smokers. Among 50 cases, (60% were diagnosed to have chronic bronchitis with or without emphysema. Chest x - ray showed details relevant to the clinical profile. ECG showed 46% cases with RVH, 64% with RAD, 26% RBBB and 70% with P pulmonale. Every patient showed echocardiographic features suggesting chronic cor pulmonale except 3 patients who showed global hypokinesia. DISCUSSION AND CONCLUSION: Many patients who had chronic cor pulmonale were found to have COPD as the underlying disease. Majority of the male patients were smokers in the present study. Echocardiogram was found to be a better diagnostic tool. Though ECG and chest x - ray can support the diagnosis, ECHO can be used as a non invasive, affordable invest igation for accurate and early diagnosis of chronic cor pulmonale KEYWORDS: Chronic cor pulmonale; Clinical profile; Chest x ray; ECG; Echocardiogram.

  3. Using Correction Equations Based on Measured Height and Weight Weakens Associations between Obesity Based on Self-Reports and Chronic Diseases

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    Cynthia L. Murray

    2013-01-01

    Full Text Available Objective. Researchers have established a preponderance of height overestimation among men and weight underestimation among women in self-reported anthropometric data, which skews obesity prevalence data and obscures obesity-chronic disease relationships. The objective of this study was to reevaluate associations between obesity and chronic diseases using body mass index (BMI correction equations derived from measured data. Methods. Measured height and weight (MHW data were collected on a subsample of the 17,126 Atlantic Canadians who participated in the 2007-2008 Canadian Community Health Survey (CCHS. To obtain corrected BMI estimates for the 17,126 adults, correction equations were developed in the MHW subsample and multiple regression procedures were used to model BMI. To test obesity-chronic disease relationships, logistic regression models were utilized. Results. The correction procedure eliminated statistically significant relations (P<0.05 between obesity and chronic bronchitis and obesity and stroke. Also, correction attenuated many relationships between adiposity and chronic disease. For example, among obese adults, there was a 13%, 12%, and 7% reduction in the adjusted odds ratios for asthma, urinary incontinence, and cardiovascular disease, respectively. Conclusion. Further research is needed to fully understand how the usage of self-reported data alters our understanding of the relationships between overweight or obesity and chronic diseases.

  4. Protection of chickens against infectious bronchitis by a recombinant fowlpox virus co-expressing IBV-S1 and chicken IFNgamma.

    Science.gov (United States)

    Wang, Yun-Feng; Sun, Yong-Ke; Tian, Zhan-Cheng; Shi, Xing-Ming; Tong, Guang-Zhi; Liu, Sheng-Wang; Zhi, Hai-Dong; Kong, Xian-Gang; Wang, Mei

    2009-11-23

    A fowlpox virus expressing the chicken infectious bronchitis virus (IBV) S1 gene of the LX4 strain (rFPV-IBVS1) and a fowlpox virus co-expressing the S1 gene and the chicken type II interferon gene (rFPV-IBVS1-ChIFNgamma) were constructed. These viruses were assessed for their immunological efficacy on specific-pathogen-free (SPF) chickens challenged with a virulent IBV. Although the antibody levels in the rFPV-IBVS1-ChIFNgamma-vaccinated group were lower than those in the attenuated live IB vaccine H120 group and the rFPV-IBVS1 group, the rFPV-IBVS1-ChIFNgamma provided the strongest protection against an IBV LX4 virus challenge (15 out of 16 chickens immunized with rFPV-IBVS1-ChIFNgamma were protected), followed by the attenuated live IB vaccine (13/16 protected) and the rFPV-IBVS1 (12/16 protected). Compared to those of the rFPV-IBVS1 and the attenuated live IB vaccine groups, chickens in the rFPV-IBVS1-ChIFNgamma group eliminated virus more quickly and decreased the presence of viral antigen more significantly in renal tissue. Examination of affected tissues revealed abnormalities in the liver, spleen, kidney, lung and trachea of chickens vaccinated with the attenuated live IB vaccine and the rFPV-IBVS1 vaccine. In rFPV-IBVS1-ChIFNgamma-vaccinated chickens, pathological changes were also observed in those organs, but were milder and lasted shorter. The lesions in the mock control group were the most severe and lasted for at least 20 days. This study demonstrated that chicken type II interferon increased the immunoprotective efficacy of rFPV-IBVS1-ChIFNgamma and normal weight gain in vaccinated chickens although it inhibited serum antibody production.

  5. S1 gene sequence analysis of infectious bronchitis virus vaccinal strains (H120 & H52 and their embryo-passaged derivatives

    Directory of Open Access Journals (Sweden)

    Bakhshesh, M.

    2016-07-01

    Full Text Available Avian infectious bronchitis is an acute and highly contagious disease that mainly causes respiratory symptoms in poultry. A number of serotypes and variants of the viral agent with poor cross-protection are the major problem to achieve desired immunity from vaccination. The S1 subunit of S glycoprotein (spike is the major determinant of IBV so that a minor change in amino acid sequence of this protein, alters the virus strain. Therefore, characterization of the sequence of S1 gene is necessary to identify virus strains and their similarities with the vaccinal strains. In this research, the S1 sequence of H52 and H120 vaccinal strains of Razi Institute was fully characterized, and also the effect of serial passages in embryonated - eggs (5 passages beyond the master seed on the S1 gene was investigated. The results showed that H120 and H52 strains of Razi Institute are 100% identical to the reference vaccine strains available in the GenBank. In addition, the H52 strain showed one amino acid substitution from the 3rd passage in which Glycine (G was replaced by Valine (V at position 118 making these passages exactly identical to the H120 strain while no change occurred for the H120 strain during these passages. Analysis of the original vaccinal strains which are widely administered in Iran, is definitely useful for prevention and control strategies against the circulating viruses. To identify the genetic change(s responsible for attenuation of these strains during passages in embryonated-egg, characterization of other genes, especially those involved in replication is recommended.

  6. Gastric gross and microscopic lesions caused by the UNAM-97 variant strain of infectious bronchitis virus after the eighth passage in specific pathogen-free chicken embryos.

    Science.gov (United States)

    Escorcia, M; Fortoul, T I; Petrone, V M; Galindo, F; López, C; Téllez, G

    2002-11-01

    Herein we report a description of gross and microscopic lesions found in specific pathogen-free chicken embryos caused by UNAM-97 infectious bronchitis virus (IBV) variant strain after the eighth passage. Embryos were divided into three groups and were inoculated in the chorioallantoic sac with 0.2 mL of UNAM-97, Mass 41 IBV (positive control), or sterile PBS (negative control). Forty-eight hours later the allatoic fluid was taken and used to start a cycle of eight passages through 9-d-old embryos. Seven days after the last passage, embryos were harvested and macroscopic lesions in all organs were recorded. Proventriculus and gizzard samples were obtained from all embryos and routinely processed for microscopic and ultrastructural examinations. The UNAM-97 IBV variant strain caused two macroscopic lesions uncommon for Mexican strains: thin-walled proventriculus and gizzard, as well as urate accumulation within an extra-embryonic peritoneal sac, leaving the body through the umbilical duct and accompanied by the yolk sac. At microscopic level, two relevant findings were observed to be produced by this variant. In the proventriculus, there was a decrease in the gland papillary branching, while the gizzard showed a significant reduction in mucosa thickness and tubular-to-proliferative-cell ratio, as well as an absence of hyaline secretion in the lumen. Electrodense material scattered in proventricular and gizzard cells was observed, with a structure consistent with that of coronaviruses. These pathological chicken embryo findings have not been reported as being caused by other IBV strains in Mexico.

  7. Relationship between Deficiency of Vitamin D and the Incidence of Asthmatic Bronchitis%维生素D 缺乏与喘息性支气管炎发病的关系

    Institute of Scientific and Technical Information of China (English)

    何玉珍; 林冬云; 蓝永乐

    2013-01-01

    Objective :By measuring children with asthmatic bronchitis serum 25-hydroxy vitamin D levels ,and to ex-plore the relationship between serum vitamin D levels and incidence of asthmatic bronchitis ,and provide a new theoreti-cal and clinical basis for the treatment of asthmatic disease .Methods :80 cases of pediatric outpatient children with asth-matic bronchitis ,were randomly divided into the VitD treatment group and the non-VitD treatment group .Healthy chil-dren during the same period 30 cases (control group) as a control .By liquid chromatography-tandem mass spectrome-try to detect serum 25-hydroxyvitamin D levels ;simultaneously record the duration of remission of clinical symptoms ,as well as six months ,the number of respite recurrence .Results:VitD tveatmert group compared with the control group serum 25-hydroxy D levels were statistically significant difference (P< 0 .01) .VitD treatment group compared with non-rapid remission of clinical symptoms of VitD treatment group ,six months respite recurrence less frequently ,two group differences were statistically significant (P<0 .05) .Conclusion:The VitD lack is closely related to the pathogen-esis of asthmatic bronchitis , may be the underlying cause of asthmatic bronchitis .Asthmatic bronchitis treatment process ,the supplement VitD alleviate clinical symptoms ,reduce respite recurrence rate .%目的:通过喘息性支气管炎患儿血清25-羟基维生素D水平的测定,探讨血清维生素D水平与喘息性支气管炎发病的关系,为小儿喘息性疾病的治疗提供新的理论和临床依据。方法:选择儿科门诊喘息性支气管炎患儿80例,随机分为VitD治疗组和非VitD治疗组,以同期健康体检儿30例作为对照组。采用液相色谱串联质谱技术检测血清25-羟基维生素D水平;同时记录喘息性支气管炎患儿临床症状的缓解时间以及半年喘息再发次数。结果:(1)治疗前VitD治疗组较对照组血清25-

  8. The analysis of asthmatic bronchitis allergen skin prick test%喘息性支气管炎患儿皮肤过敏原点刺检测结果分析

    Institute of Scientific and Technical Information of China (English)

    姜君

    2013-01-01

    Objective To observe the allergen skin prick test for 12g patients with asthmatoid bronchitis to proceed early intervening treatment.Methods The dust mite allergen,dermatophagoides pteronyssinus 14 kinds of common allergen were detected in the 128 patients with pediatric asthmatoid bronchitis with the allergen skin prick test.According to age,the children were divided into two groups(more than 7 years old age group and under the age of seven group).Inhaled allergens (dust mites,household dust mites,the pollen of humulus scandens,dog hair,phoenix tree,etc.) and food allergens (eggs,milk,sea crab,scallops,etc.) were given in two groups.Afterwards the positive rate was analyzed.Results Among these 128 patients with pediatric asthmatoid bronchitis,the positive rate of allergen prick test result was 85.0% ; the inhaled allergens mid-point sting test result was 74.1% ; the food allergens was 10.8%.Conclusions The allergens can be found quickly and easily in the patients of pediatric asthmatoid bronchitis and the symptom severity of the patients of pediatric asthmatoid bronchitis can be effectively indicated with the allergen skin prick test.The skin prick test should be used widely in checking the allergens of pediatric asthmatoid bronchitis.%目的 探讨皮肤过敏原点刺试验检测喘息性支气管炎患儿临床效果.方法 对2012年1月1日至12月31日于我院就诊并确诊为喘息性支气管炎的128例患儿进行皮肤过敏原点刺试验,总点数为1792点,选取的过敏原为粉尘螨、户尘螨等14种常见的过敏原,给予患儿皮肤过敏原点刺,对吸入性过敏原(粉尘螨、户尘螨、葎草花粉、狗毛、梧桐等)及食物性过敏原(鸡蛋清、牛奶、海蟹、扇贝等)相关情况进行观察和过敏原阳性率等数据进行分析.结果 128例喘息性支气管炎患者过敏原点刺检测结果为阳性占85.0%(1523/1792),其中在吸入性过敏原中点刺检测结果阳性占74.1%(1328/1792),而食

  9. 小儿喘息性支气管炎的雾化吸入治疗疗效观察及护理措施%Effect and Nursing Measures of Nebulization in the Treatment of Asthmatic Bronchitis in Children

    Institute of Scientific and Technical Information of China (English)

    李克芬

    2012-01-01

      目的:观察探讨雾化吸入治疗小儿喘息性支气管炎的效果及护理措施.方法:选取本院住院喘息性支气管炎患儿80例,随机分为治疗组和对照组,每组40例,根据患儿病情均给予抗感染、止咳、化痰等治疗.治疗组给予布地奈德和硫酸特布他林雾化吸入,对照组给予静脉地塞米松滴注.结果:治疗组总有效率95%,对照组77.5%,两组比较差异有统计学意义.结论:小儿喘息性支气管炎采取雾化吸入治疗,效果良好.%  Objective: To observe and discusses the effect and nursing measures of nebulization in the treatment of asthmatic bronchitis in children.Method:80 cases with asthmatic bronchitis in children were randomly divided into treatment group and compare group,40 cases in each group, according to the condition of children are given anti-infection,anti-tussive,phlegm,and so treatment.The treatment group was given budesonide and sulfuric acid terbutaline nebulization inhalation,and the compare group given dexamethasone intravenous injection.Result:Treatment group total effectiveness was 95%,the comparison group was 77.5%,two groups of comparisons difference was statistically significance.Conclusion:The curative effect of nebulization inhalation in the treatment of asthmatic bronchitis is affirmative,worthy of clinical application.

  10. The curative effect observation of ambroxol in the treatment of bronchitis in adults%氨溴索在成人支气管炎治疗中的疗效观察

    Institute of Scientific and Technical Information of China (English)

    黑红香

    2016-01-01

    Objective Study the ammonia bromine rope in the treatment of adult bronchitis curative effect. Methods Choose our hospital 72 cases of patients with adult bronchitis were divided into observation group and control group.Two groups of hydrochloric acid were used respectively to ammonia bromine and conventional treatment methods, to compare the curative effect of two groups of patients.Results Efficient treatment of observation group was obviously higher than the control group, two groups of adverse reaction rate has no obvious difference (P>0.05).Conclusion In the treatment of adult bronchitis with hydrochloric acid ammonia bromine to treatment can improve the curative effect of treatment.%目的:研究氨溴索在成人支气管炎治疗中的疗效。方法选择我院收治的成人支气管炎患者72例,分为观察组和对照组。两组分别采用盐酸氨溴索和常规的治疗方法治疗,对两组患者的疗效进行比较。结果观察组的治疗有效率明显的高于对照组,但两组不良的反应率对比,差异无统计学意义(P>0.05)。结论用盐酸氨溴索来治疗成人支气管炎的可以提高治疗的疗效。

  11. 护理干预对小儿支气管炎的临床治疗效果的影响%Explore the effect of nursing intervention in clinical treatment of bronchitis in children

    Institute of Scientific and Technical Information of China (English)

    刘霞

    2015-01-01

    Objective To investigate the clinical efficacy of nursing intervention in clinical treatment of bronchitis in children.Methods 68 cases of children with bronchitis were selected as objects from 2012 to 2013, and divided into two groups. A regular basis treatment and nursing care were included in the control group, and nursing intervention was included the observation group on the basis of the measure in the control group.Results The elimination of time, eliminating the time and length of hospital stay of the children in observation group were significantly shorter than that in the control group(P<0.05). Conclusion To enhance nursing intervention is good for children with bronchitis with shorter remission time and length of hospital stay.%目的 探讨护理干预对小儿支气管炎的临床治疗效果的影响.方法 选取2012年~2013年收诊的支气管炎患儿共68例,并随机方式将其分成观察组和对照组两组,给予对照组患儿常规基础治疗与护理,给予观察组患儿增强性护理干预,评估两组患儿的临床护理结局.结果 观察组患儿护理后的喘憋消除时间、咳嗽消除时间与住院时间均要明显短于对照组,差异有统计学意义(P<0.05).结论 对支气管炎患儿运用增强护理干预,能使患儿临床症状尽早消除,缩短住院时间.

  12. Clinical Study on Hydrochloride Ambroxol Oral Medication Treatment of Bronchitis%盐酸氨溴索口服液治疗支气管炎的临床探析

    Institute of Scientific and Technical Information of China (English)

    巩哜萍

    2015-01-01

    Objective Clinical effect of hydrochloride ambroxol oral medication treatment of bronchitis is to be investigated. Methods Choose 108 bronchitis patients who are treated in hospital from October 2013 to June 2014 and separate them into control group and study group according to random number table; patients in control group are given bromhexine medication treatment,while patients in study group are given hydrochloride ambroxol oral medication treatment and then compare treatment effects between two groups. Results Treatment effect in study group is much more favorable than that in control group; there is a treatment differential between two groups,and such a differential has statistic value(P<0.05). Conclusion Hydrochloride ambroxol oral medication is of efficacy in treatment of bronchitis; such a treatment approach is quite worthwhile to be promoted and applied clinical y.%目的:对盐酸氨溴索口服液治疗支气管炎的临床效果进行探究。方法选取于2013年10月~2014年6月收治的108例支气管炎患者,采用随机数字表法分为对照组和观察组,对照组患者给予溴己新治疗,观察组患者给予盐酸氨溴索口服液治疗,对两组患者治疗效果进行对比分析。结果观察组的治疗效果明显优于对照组,差异有统计学意义(P<0.05)。结论使用盐酸氨溴索口服液治疗支气管炎效果较为显著,值得在临床实践中推广使用。

  13. The Yanhuning injection in the treatment of acute bronchitis effect observed%炎琥宁注射液治疗急性支气管炎的效果观察

    Institute of Scientific and Technical Information of China (English)

    李瑛

    2012-01-01

      Objective Used in acute bronchitis Yanhuning injection effect for study. Methods Random selection in our hospital from June 2010 to June 2012 79 patients with acute bronchitis, divided into A and B group, A group of 45 patients for the treatment group, B group 34 patients of the control group were given Yanhuning injectionfluids and amoxicilin healing.Results A group of patients after treatment, fever, and other symptoms of wheezing and wheezing disappeared improve less than group B patients, treatment efficiency than in group B, the incidence of adverse reactions was significantly lower than that in group B patients.Conclusion Yanhuning injection used in acute bronchitis, a faster recovery of the patient's condition, there are more efficient.%  目的对炎琥宁注射液应用于急性支气管炎的效果加以研究分析。方法随机选择我院2010年6月-2012年6月急性支气管炎患者79名,分成A、B组,A组45名患者为治疗组,B组34名患者为对照组,分别给予炎琥宁注射液和阿莫西林医治。结果经治疗,A组患者发热、喘憋以及喘鸣音消失等病症改善时间均少于B组患者,治疗有效率高于B组,不良反应发生率明显低于B组患者。结论炎琥宁注射液应用于急性支气管炎,患者病症恢复较快,有效率较高。

  14. Report of 5 cases of pediatric plastic bronchitis and review of related literature%儿童塑型性支气管炎五例并文献复习

    Institute of Scientific and Technical Information of China (English)

    朱春梅; 曹玲; 常丽; 张琪; 王菲; 任晓旭

    2013-01-01

    To report the clinical course of 5 cases of pediatric plastic bronchitis and review the related literature.A total of 113 cases of pediatric plastic bronchitis occurring in China from 2000 to 2012 were retrieved through the databases of CNKI and Wanfang Med Online.Retrospective analyses were performed for the main symptoms,courses,etiologies,imaging findings,histopathological classifications,therapies and prognosis of 118 cases.Pediatric plastic bronchitis was one of critical diseases.Most of them had a rapid onset and a mortality rate.Bronchoscopy examination was essential for definite diagnosis and effective treatment.Airway management and chest physiotherapy were primary adjuvant tools.Early diagnosis and bronchoscopic treatment might result in improved prognosis.%报告5例儿童塑型性支气管炎病例的临床诊治经过,并检索中国知网(CNKI)和万方医学数据库2000年1月至2012年6月相关病例报告113例,回顾性分析118例患儿的主要临床症状、病程、病原学分布、影像学表现、病理分类、治疗和预后.儿童塑型性支气管炎属高危性疾病,多数起病急,病死率高,确诊依靠支气管镜检查,支气管镜异物取出术及灌洗是最有效的治疗方法,气道管理和胸部理疗是重要的辅助治疗手段,经早期确诊和治疗预后良好.

  15. Chronic Kidney Diseases

    Science.gov (United States)

    ... Room? What Happens in the Operating Room? Chronic Kidney Diseases KidsHealth > For Kids > Chronic Kidney Diseases Print ... re talking about your kidneys. What Are the Kidneys? Your kidneys are tucked under your lower ribs ...

  16. Diet - chronic kidney disease

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/002442.htm Diet - chronic kidney disease To use the sharing features on this page, ... make changes to your diet when you have chronic kidney disease. These changes may include limiting fluids, eating a ...

  17. Chronic granulomatous disease

    Science.gov (United States)

    CGD; Fatal granulomatosis of childhood; Chronic granulomatous disease of childhood; Progressive septic granulomatosis ... In chronic granulomatous disease (CGD), immune system cells called phagocytes are unable to kill some types of bacteria and ...

  18. Chronic mucus hypersecretion

    DEFF Research Database (Denmark)

    Ulrik, Charlotte Suppli; von Linstow, Marie-Louise; Nepper-Christensen, Steen;

    2005-01-01

    To investigate if chronic mucus hypersecretion (CMH) can be used as a marker of asthma in young adults.......To investigate if chronic mucus hypersecretion (CMH) can be used as a marker of asthma in young adults....

  19. Chronic tophaceous gout

    Directory of Open Access Journals (Sweden)

    Thappa D

    1993-01-01

    Full Text Available A rare case of chronic tophaceous gout, in a 27-year-old female on diuretics for chronic congestive cardiac failure with characteristic histopathological and radiological changes is reported.

  20. Chronic Pancreatitis in Children

    Science.gov (United States)

    ... maintaining good health. Can chronic pancreatitis give my child cancer? If your child has chronic pancreatitis, he or she will be at an increased risk of developing pancreatic cancer compared to the general population. The degree of ...

  1. People Experiencing Chronic Homelessness

    Science.gov (United States)

    ... Goals Ending Chronic Homelessness Share This: Ending Chronic Homelessness Last updated on January 19, 2017 We can ... the USICH newsletter. We know how to end homelessness. Let's do it, together. Sign up for our ...

  2. Clinical observation on treating 24 cases of bronchitis by the Sangju decoction%加减桑菊饮治疗支气管炎24例疗效观察

    Institute of Scientific and Technical Information of China (English)

    佘佑林

    2013-01-01

      目的:探讨中药组方桑菊饮的加减治疗支气管炎的临床疗效,以期为临床用药提供数据支持。方法:将我院于2011年6月~2012年6月间收治的48例支气管炎患者随机分为两组,每组24例患者,实验组根据中医辨证论治的原则给予加减桑菊饮治疗;对照组则采用急支糖浆进行治疗,治疗7d后对比两组疗效。结果:经治疗后,实验组患者总有效率为83.3%;对照组为66.7%,实验组疗效显著优于对照组(x2=4.763,P<0.05)。结论:根据中医辨证论治的原则采用加减桑菊饮治疗支气管炎疗效显著,值得进行临床推广。%Objective:To investigate the clinical efficacy of TCD Sangju decoction in treating bronchitis, to provide data support for the clinical use of drugs. Methods:48 cases of bronchitis patients admitted to our hospital from June 2011 to June 2012 were randomly divided into two groups, 24 cases in each group. Experimental group was given addition and subtraction of Sangju decoction according to the principles of TCM;the control group received the treatment of acute bronchitis syrup, after 7 days treatment, comparing the clinical effect of the two groups. Results: The total efficiency of the treatment group was 83.3%, and 66.7% in the control group. There was a significant difference (P<0.05) in two groups. Conclusion:The treatment of bronchitis with addition and subtraction of SangJu decoction which is according to the principles of TCM obtained a significant clinical effects.

  3. 自拟麻蝉平喘汤治疗婴幼儿毛细支气管炎的疗效观察%Curative Effect of Self-made Machan Asthma Relieving Decoction on Capillary Bronchitis of Infants

    Institute of Scientific and Technical Information of China (English)

    张健

    2014-01-01

    目的:观察自拟麻蝉平喘汤治疗婴幼儿毛细支气管炎的临床治疗效果。方法将76例毛细支气管炎患儿随机分为两组,对照组40例给予常规治疗,治疗组36例于常规治疗基础上加用自拟麻蝉平喘汤口服,疗程结束后对两组治疗效果进行比较分析。结果两组症状与体征消失、缓解时间、临床疗效比较,有统计学意义(P<0.01),治疗组疗效明显优于对照组。结论自拟麻蝉平喘汤治疗婴幼儿毛细支气管炎安全有效,可以明显缩短病程及提高临床疗效。%Objective To observe the clinical curative effect of self-made Machan asthma relieving decoction on capillary bronchitis of infants. Methods 76 infants with capillary bronchitis were randomly divided into 2 groups: treatment group(n=36)and control group(n=40), routine treatment was performed in both group while self-made Machan asthma relieving decoction was added to infants in treatment group;the curative effects of the 2 groups were compared and analyzed after treatment. Results The comparison in the dis-appearance of symptoms and signs of capillary bronchitis, the relieving time and the clinical curative effect between the infants of the 2 groups was of statistical significance(P<0.01), and the curative effect in treatment group was obviously superior to that in control group. Conclusions The self-made Machan asthma relieving decoction is safe and effective for infants with capillary bronchitis, and it can significantly shorten the course of the disease and promote the clinical curative effect.

  4. Using oxygen at home

    Science.gov (United States)

    Oxygen - home use; COPD - home oxygen; Chronic obstructive airways disease - home oxygen; Chronic obstructive lung disease - home oxygen; Chronic bronchitis - home oxygen; Emphysema - home oxygen; Chronic respiratory ...

  5. Approaching chronic sinusitis.

    Science.gov (United States)

    Sarber, Kathleen M; Dion, Gregory Robert; Weitzel, Erik K; McMains, Kevin C

    2013-11-01

    Chronic sinusitis is a common disease that encompasses a number of syndromes that are characterized by sinonasal mucosal inflammation. Chronic sinusitis can be defined as two or more of the following symptoms lasting for more than 12 consecutive weeks: discolored rhinorrhea, postnasal drip, nasal obstruction, facial pressure or pain, or decreased sense of smell. Chronic sinusitis is further classified as chronic sinusitis with polyposis, chronic sinusitis without polyposis, or allergic fungal sinusitis using physical examination, and histologic and radiographic findings. Treatment methods for chronic sinusitis are based upon categorization of the disease and include oral and inhaled corticosteroids, nasal saline irrigations, and antibiotics in selected patients. Understanding the various forms of chronic sinusitis and managing and ruling out comorbidities are key to successful management of this common disorder.

  6. Clinical features and therapy of persistent bacterial bronchitis in 31 children%持续性细菌性支气管炎31例诊治分析

    Institute of Scientific and Technical Information of China (English)

    史军然; 刘金荣; 李惠民; 王维; 赵顺英

    2016-01-01

    目的 探讨持续性细菌性支气管炎的临床诊治要点.方法 对2010年10月至2014年5月在首都医科大学附属北京儿童医院呼吸二科住院的31例持续性细菌性支气管炎患儿性别、发病年龄、症状、肺部听诊、胸部影像学、支气管镜下表现及呼吸道分泌物细菌培养、对抗生素的应用反应等进行回顾性分析.结果 31例患儿男17例,女14例,发病年龄均在3岁以下,主要临床表现:有痰咳嗽,持续4~11周,病程中曾有发热13例,伴有喘息25例.所有患儿肺部听诊闻及痰鸣音.胸部X线片提示均有两肺纹理粗多、模糊,6例有散在小斑片影.肺部高分辨CT发现25例有支气管壁增厚,其中18例伴有支气管周围小斑片影,7例伴有陈旧性肺炎(5例合并条状肺不张).6例仅表现为模糊的小叶中心性小结节和透光度不均匀或磨玻璃影.支气管镜下发现支气管腔内有白色分泌物.16例为肺炎链球菌感染.28例应用阿莫西林克拉维酸钾或第二、三代头孢菌素和加酶抑制剂2周以上痊愈.最终应用碳青霉烯类、替考拉宁、利奈唑胺各1例.结论 持续性细菌性支气管炎常发生于3岁以下,主要临床表现为有痰咳嗽持续4周以上,可伴有发热、喘息,肺部高分辨CT常表现为支气管壁增厚,呼吸道分泌物细菌培养常为肺炎链球菌,大部分病例应用阿莫西林克拉维酸钾或第二、三代头孢菌素和加酶抑制剂治疗2周以上痊愈.%Objective To investigate the clinical features and therapy of persistent bacterial bronchitis (PBB).Method A retrospective review of 31 patients with PBB from Octorber 2010 to May 2014 in Department 2 of Respiratory Diseases in Beijing Children's Hospital was undertaken.Result (1) The patients (17 boys and 14 girls) were 6 months to 3 years old.The main complaint was chronic wet cough (>4 weeks);13 cases had fever and 25 cases had wheezing.Rattle was heard on auscultation in all patients.(2

  7. Pharmacology and clinical efficacy of erdosteine in chronic obstructive pulmonary disease.

    Science.gov (United States)

    Moretti, Maurizio

    2007-12-01

    Erdosteine is a multimechanism, mucolytic agent that decreases the sputum viscoelastic properties and bacterial adhesion to the cell membrane, endowed with bronchial anti-inflammatory activity and a scavenging effect on free oxidant radicals. Erdosteine is a prodrug and metabolite I is the active metabolite of erdosteine owing to its free thiol group. In acute infective exacerbation of chronic bronchitis or chronic obstructive pulmonary disease (COPD), adding erdosteine to standard treatment significantly modified the outcome by improving the symptoms and reducing the length of disease. Furthermore, erdosteine has shown a synergism with antibiotic therapy. In stable COPD patients, long-term treatment with erdosteine had a protective effect against exacerbations by reducing the rate of exacerbations and hospitalizations in the study period. A total of 8 months of treatment with erdosteine significantly improved the patients' health status and preserved lung function. Erdosteine has a scavenging effect on free oxidant radicals by a direct and indirect antioxidative effect and the final result is a protective effect against tissue damage, as demonstrated in animal studies. In view of the persuasive evidence that oxidative stress is important in the pathophysiology of COPD, erdosteine appears to be a logical approach to therapy.

  8. THE EFFECTS OF PRACTICING SWIMMING IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE. CASE STUDY

    Directory of Open Access Journals (Sweden)

    Petrescu S.

    2015-08-01

    Full Text Available Chronic obstructive pulmonary disease (COPD is comprised primarily of two related diseases - chronic bronchitis and emphysema. Clinical research on the effects of swimming on the quality of the life of patients with various lung diseases showed that the use of water therapy programs have significant effects on the induction of pulmonary edema as well as on mild to moderate asthma. The case study presented in this study, aged 52, male, from urban area, smoker (30PA, with a weight of 96 kg and a height of 168 cm, was diagnosed with COPD in GOLD III std about 2 years ago and abdominal obesity. The functional examinations have revealed a mixed ventilatory dysfunction with FEV of 48.6% and 68.3% CV. The therapy with tiotropium and beta 2 agonists initiated as needed, along with physical therapy. After the application of aquatic programs for 6 months the results have highlighted significant changes in the lung functionality and the quality of everyday life.

  9. Levocloperastine in the treatment of chronic nonproductive cough: comparative efficacy versus standard antitussive agents.

    Science.gov (United States)

    Aliprandi, P; Castelli, C; Bernorio, S; Dell'Abate, E; Carrara, M

    2004-01-01

    The medical and social impact of cough is substantial. Current antitussive agents at effective doses have adverse events such as drowsiness, nausea and constipation that limit their use. There is also recent evidence that standard antitussive agents, such as codeine, may not reduce cough during upper respiratory infections. Therefore, there is a need for more effective and better-tolerated agents. The efficacy of levocloperastine, a novel antitussive, which acts both centrally on the cough center and on peripheral receptors in the tracheobronchial tree in treating chronic cough, was compared with that of other standard antitussive agents (codeine, levodropropizine and DL-cloperastine) in six open clinical trials. The studies enrolled patients of all ages with cough associated with various respiratory disorders including bronchitis, asthma, pneumonia and chronic obstructive pulmonary disease. Levocloperastine significantly improved cough symptoms (intensity and frequency of cough) in all trials, and improvements were observed after the first day of treatment. In children, levocloperastine reduced nighttime awakenings and irritability, and in adults it was effective in treating cough induced by angiotensin-converting enzyme inhibitors. When compared with other antitussive agents, levocloperastine had improved or comparable efficacy, with a more rapid onset of action. Importantly, no evidence of central adverse events was recorded with levocloperastine, whereas drowsiness was reported by a significant number of patients receiving codeine. Levocloperastine is an effective antitussive agent for the treatment of cough in patients of all ages. It has a more rapid onset of action than standard agents with an improved tolerability profile.

  10. Chronic health effects of sulphur mustard exposure with special reference to Iranian veterans

    Directory of Open Access Journals (Sweden)

    B Balali-Mood

    2008-01-01

    Full Text Available The widespread use of sulphur mustard (SM as an incapacitating chemical warfare agent in the past century has proved its long-lasting toxic effects. It may also be used as a chemical terrorist agent. Therefore, all health professionals should have sufficient knowledge and be prepared for any such chemical attack. SM exerts direct toxic effects on the eyes, skin, and respiratory tissue, with subsequent systemic action on the nervous, immunological, haematological, digestive, and reproductive systems. SM is an alkylating agent that affects DNA synthesis, and, thus, delayed complications have been seen since the First World War. Cases of malignancies in the target organs, particularly in haematopoietic, respiratory, and digestive systems, have been reported. Important delayed respiratory complications include chronic bronchitis, bronchiectasis, frequent bronchopneumonia, and pulmonary fibrosis, all of which tend to deteriorate with time. Severe dry skin, delayed keratitis, and reduction of natural killer cells with subsequent increased risk of infections and malignancies are also among the most distressing long-term consequences of SM intoxication. However, despite a lot of research over the past decades on Iranian veterans, there are still major gaps in the SM literature. Immunological and neurological dysfunction, as well as the relationship between SM exposure and mutagenicity, carcinogenicity, and teratogenicity are important fields that require further studies, particularly on Iranian veterans with chronic health effects of SM poisoning. There is also a paucity of information on the medical management of acute and delayed toxic effects of SM poisoning—a subject that greatly challenges health care specialists.

  11. 鸡传染性支气管炎病毒感染的分子机制%Advance in Molecular Mechanism of Infectious Bronchitis Virus Infection

    Institute of Scientific and Technical Information of China (English)

    孙裴; 施雷; 魏建忠; 李郁; 王桂军

    2013-01-01

    Infection of infectious bronchitis virus (IBV)is seriously harmful to the world poultry industry. IBV in chicken in vivo tissue tropism can be divided into 6 types:respiratory type,kidney type,addicted intestinal type,muscular type,glandular type and fallopian tube type.Pathological lesions of the body′s main organs caused by IBV strains of different tissue tropism have significant differences.What is the mo-lecular mechanism of IBV infection,its tissue and cellular tropism?It is not yet fully understood.In this paper,the brief advance in the relationship of IBV molecular variation and Changes in virulence,receptor-mediated cell IBV infections and IBV different characteristics due with different types of cells in vitro culti-vation,were reviewed to provide a reference for the future research of the molecular mechanism of IBV in-fection and tissue tropism.%鸡传染性支气管炎病毒(IBV)的感染严重危害世界养鸡业,IBV 在鸡体内的组织亲嗜性主要可分为呼吸型、肾型、嗜肠型、肌肉型、腺胃型和输卵管型等。不同组织亲嗜性的 IBV 毒株造成机体病理损伤主要部位有明显差异。IBV 感染及组织和细胞嗜性的分子机理到底如何,目前尚未完全弄清楚。论文对IBV 分子变异与毒力变化、细胞受体介导 IBV 感染及不同种类的体外细胞对 IBV 培养的不同特性等研究进展进行综述,旨在为 IBV 感染的组织亲嗜性及体外培养细胞感染的分子机制的研究提供参考。

  12. Biofilms in chronic wounds.

    Science.gov (United States)

    James, Garth A; Swogger, Ellen; Wolcott, Randall; Pulcini, Elinor deLancey; Secor, Patrick; Sestrich, Jennifer; Costerton, John W; Stewart, Philip S

    2008-01-01

    Chronic wounds including diabetic foot ulcers, pressure ulcers, and venous leg ulcers are a worldwide health problem. It has been speculated that bacteria colonizing chronic wounds exist as highly persistent biofilm communities. This research examined chronic and acute wounds for biofilms and characterized microorganisms inhabiting these wounds. Chronic wound specimens were obtained from 77 subjects and acute wound specimens were obtained from 16 subjects. Culture data were collected using standard clinical techniques. Light and scanning electron microscopy techniques were used to analyze 50 of the chronic wound specimens and the 16 acute wound specimens. Molecular analyses were performed on the remaining 27 chronic wound specimens using denaturing gradient gel electrophoresis and sequence analysis. Of the 50 chronic wound specimens evaluated by microscopy, 30 were characterized as containing biofilm (60%), whereas only one of the 16 acute wound specimens was characterized as containing biofilm (6%). This was a statistically significant difference (p<0.001). Molecular analyses of chronic wound specimens revealed diverse polymicrobial communities and the presence of bacteria, including strictly anaerobic bacteria, not revealed by culture. Bacterial biofilm prevalence in specimens from chronic wounds relative to acute wounds observed in this study provides evidence that biofilms may be abundant in chronic wounds.

  13. [Thr prognostic value of chronic cough, sputum and spirometry assessed by 10-year mortality among 1487 working men (author's transl].

    Science.gov (United States)

    Kauffmann, F; Brille, D; Lellouch, J

    1975-01-01

    The aim of the present study is to find out whether or not the diagnosis of chronic bronchitis at an early stage of the disease makes it possible to forecast an excess of mortality within 10 years, among 1487 men examined in 1960/61 while they were at work and aged at the time between 30 and 59 years. After having shown the prognostic value of chronic phlegm and spirographic measurements (VC, FEV1.0, FEV1.0/VC), we tried to state precisely their prognostic value by controlling the tobacco consumption and the socio-occupational class, which are bound to them and are themselves prognostic. FEV 1.0 is the most discriminant variable; its reduction is prognostic as young as 35. Survival-rates decrease regularly with the reduction of FEV1.0; this prognostic role seems to remain in all sociooccupational classes and for smokers as well as for non-smokers; it is more evident for the men who had chronic phlegm than in those who did not have such a symptom. It has been impossible to draw clear conclusions about the prognostic value of phlegm on these points because of interaction existing between phlegm and age.

  14. The clinical and economic burden of chronic obstructive pulmonary disease in the USA.

    Science.gov (United States)

    Guarascio, Anthony J; Ray, Shauntá M; Finch, Christopher K; Self, Timothy H

    2013-01-01

    Chronic obstructive pulmonary disease (COPD) is the third most common cause of death in the USA. In 2010, the cost of COPD in the USA was projected to be approximately US$50 billion, which includes $20 billion in indirect costs and $30 billion in direct health care expenditures. These costs can be expected to continue to rise with this progressive disease. Costs increase with increasing severity of disease, and hospital stays account for the majority of these costs. Patients are diagnosed with COPD following a multifactorial assessment that includes spirometry, clinical presentation, symptomatology, and risk factors. Smoking cessation interventions are the most influential factor in COPD management. The primary goal of chronic COPD management is stabilization of chronic disease and prevention of acute exacerbations. Bronchodilators are the mainstay of COPD therapy. Patients with few symptoms and low exacerbation risk should be treated with a short-acting bronchodilator as needed for breathlessness. Progression of symptoms, as well as possible decline in forced expiratory volume in the first second of expiration (FEV1), warrant the use of long-acting bronchodilators. For patients with frequent exacerbations with or without consistent symptoms, inhaled corticosteroids should be considered in addition to a long-acting beta2-agonist (LABA) or long-acting muscarinic antagonist (LAMA) and may even consist of "triple therapy" with all three agents with more severe disease. Phosphodiesterase-4 inhibitors may be an option in patients with frequent exacerbations and symptoms of chronic bronchitis. In addition to a variety of novel ultra-LABAs, LAMAs and combination bronchodilator and inhaled corticosteroid (ICS) therapies, other bronchodilators with a variety of mechanisms are also being considered, to expand therapeutic options for the treatment of COPD. With more than 50 new medications in the pipeline for the treatment of COPD, optimal management will continue to evolve

  15. Influence of sex on chronic obstructive pulmonary disease risk and treatment outcomes

    Directory of Open Access Journals (Sweden)

    Aryal S

    2014-10-01

    Full Text Available Shambhu Aryal,1 Enrique Diaz-Guzman,2 David M Mannino3 1Division of Pulmonary, Allergy and Critical Care Medicine, Duke University, Durham, NC, 2Division of Pulmonary, Allergy and Critical Care, University of Alabama, Birmingham, AL, 3Department of Preventive Medicine and Environmental Health, University of Kentucky, Lexington, KY, USA Abstract: Chronic obstructive pulmonary disease (COPD, one of the most common chronic diseases and a leading cause of death, has historically been considered a disease of men. However, there has been a rapid increase in the prevalence, morbidity, and mortality of COPD in women over the last two decades. This has largely been attributed to historical increases in tobacco consumption among women. But the influence of sex on COPD is complex and involves several other factors, including differential susceptibility to the effects of tobacco, anatomic, hormonal, and behavioral differences, and differential response to therapy. Interestingly, nonsmokers with COPD are more likely to be women. In addition, women with COPD are more likely to have a chronic bronchitis phenotype, suffer from less cardiovascular comorbidity, have more concomitant depression and osteoporosis, and have a better outcome with acute exacerbations. Women historically have had lower mortality with COPD, but this is changing as well. There are also differences in how men and women respond to different therapies. Despite the changing face of COPD, care providers continue to harbor a sex bias, leading to underdiagnosis and delayed diagnosis of COPD in women. In this review, we present the current knowledge on the influence of sex on COPD risk factors, epidemiology, diagnosis, comorbidities, treatment, and outcomes, and how this knowledge may be applied to improve clinical practices and advance research. Keywords: chronic obstructive lung disease, sex, smoking, comorbidity, sex bias

  16. Pulmonary arterial hypertension and cor pulmonale associated with chronic domestic woodsmoke inhalation

    Energy Technology Data Exchange (ETDEWEB)

    Sandoval, J.; Salas, J.; Martinez-Guerra, M.L.; Gomez, A.; Martinez, C.; Portales, A.; Palomar, A.; Villegas, M.; Barrios, R. (Instituto Nacional de Cardiologia, Ignacio Chavez, Mexico City (Mexico))

    1993-01-01

    We describe the clinical, radiologic, functional, and pulmonary hemodynamic characteristics of a group of 30 nonsmoking patients with a lung disease that may be related to intense, long-standing indoor wood-smoke exposure. The endoscopic and some of the pathologic findings are also presented. Intense and prolonged wood-smoke inhalation may produce a chronic pulmonary disease that is similar in many aspects to other forms of inorganic dust-exposure interstitial lung disease. It affects mostly country women in their 60s, and severe dyspnea and cough are the outstanding complaints. The chest roentgenograms show a diffuse, bilateral, reticulonodular pattern, combined with normalized or hyperinflated lungs, as well as indirect signs of pulmonary arterial hypertension (PAH). On the pulmonary function test the patients show a mixed restrictive-obstructive pattern with severe hypoxemia and variable degrees of hypercapnia. Endoscopic findings are those of acute and chronic bronchitis and intense anthracotic staining of the airways appears to be quite characteristic. Fibrous and inflammatory focal thickening of the alveolar septa as well as diffuse parenchymal anthracotic deposits are the most prominent pathologic findings, although inflammatory changes of the bronchial epithelium are also present. The patients had severe PAH in which, as in other chronic lung diseases, chronic alveolar hypoxia may play the main pathogenetic role. However, PAH in wood-smoke inhalation-associated lung disease (WSIALD) appears to be more severe than in other forms of interstitial lung disease and tobacco-related COPD. The patients we studied are a selected group and they may represent one end of the spectrum of the WSIALD.

  17. Chronic Inflammatory Polyneuropathy

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2007-02-01

    Full Text Available Thirteen children with chronic inflammatory demyelinating polyneuropathy monitored between 1975 and 2005 are reported from Centre hospitalier universitaire Sainte-Justine, Montreal, Canada.

  18. Using Health Utility Index (HUI for Measuring the Impact on Health-Related Quality of Life (HRQL Among Individuals with Chronic Diseases

    Directory of Open Access Journals (Sweden)

    Frank Mo

    2004-01-01

    Full Text Available Quality of life is an important indicator in assessing the burden of disease, especially for chronic conditions. The Health Utilities Index (HUI is a recently developed system for measuring the overall health status and health-related quality of life (HRQL of individuals, clinical groups, and general populations. Using the HUI (constructed based on eight attributes: vision, hearing, speech, mobility, dexterity, cognition, emotion, and pain/discomfort to measure the HRQL for chronic disease patients and to detect possible associations between HUI system and various chronic conditions, this study provides information to improve the management of chronic diseases.This study is of interest to data analysts, policy makers, and public health practitioners involved in descriptive clinical studies, clinical trials, program evaluation, population health planning, and assessments. Based on the Canadian Community Health Survey (CCHS for 2000–01, the HUI was used to measure the quality of life for individuals living with various chronic conditions (Alzheimer/other dementia, effects of stroke, urinary incontinence, arthritis/rheumatism, bowel disorder, cataracts, back problems, stomach/intestinal ulcers, emphysema/COPD, chronic bronchitis, epilepsy, heart disease, diabetes, migraine headaches, glaucoma, asthma, fibromyalgia, cancers, high blood pressure, multiple sclerosis, thyroid condition, and other remaining chronic diseases. Logistic Regression Model was employed to estimate the associations between the overall HUI scores and various chronic conditions. The HUI scores ranged from 0.00 (corresponding to a state close to death to 1.00 (corresponding to perfect health; negative scores reflect health states considered worse than death. The mean HUI score by sex and age group indicated the typical quality of life for persons with various chronic conditions. Logistic Regression results showed a strong relationship between low HUI scores (≤ 0.5 and 0.06

  19. 观察小儿化痰止咳颗粒治疗小儿支气管炎的疗效%Observation on Curative Effect of the Infantile Phlegm Cough Particles in Child Bronchitis

    Institute of Scientific and Technical Information of China (English)

    李向明; 郭思岐

    2016-01-01

    Objective To observe curative effect of the infantile phlegm cough particles in the child bronchitis.MethodsThis article selected 48 cases of infantile bronchitis patients in the hospital from January, 2014 to May 2015,they were randomly divided into treatment group and control group,control group adopted ammonia bromine treatment, treatment group was treated with infantile phlegm cough particles, comparing the two groups of patients with clinical symptoms.ResultsTwo groups of patients and lung rale disappearing time had significant differences(P<0.05).Conclusion Infantile bronchitis patients with infantile phlegm cough particles after treatment can obviously eliminate adverse factors,improve patients with bronchial inflammation early.%目的:观察小儿化痰止咳颗粒治疗小儿支气管炎的疗效。方法本文选取我院于2014年1月~2015年5月收治的48例小儿支气管炎患者,将其随机分为治疗组和对照组,对照组采用氨溴索治疗,治疗组采用小儿化痰止咳颗粒治疗,对比两组患者的临床症状改善情况。结果两组患者的止咳好转时间以及肺部罗音消失时间指标差异有统计学意义(P<0.05)。结论小儿支气管炎患者采用小儿化痰止咳颗粒治疗后,可以缓解患者的支气管炎病症,消除不良因素影响,促进患者支气管炎症反应及早改善。

  20. 氧气驱动雾化吸入治疗小儿毛细支气管炎的疗效观察%Oxygen aerosol inhalation to treat infantile capil ary bronchitis curative ef ect observation

    Institute of Scientific and Technical Information of China (English)

    肖菊霞

    2015-01-01

    objective:to study the oxygen aerosol inhalation in the treatment of infantile capil ary bronchitis curative ef ect and nursing care.Methods:126 cases of capil ary bronchitis patients were randomly divided into observation group and control group.The control group,62 cases of the conventional comprehensive treatment with traditional way of ultrasonic atomization in-halation.Observation group 64 cases on the basis of routine comprehensive treatment,give driven by oxygen atomization inhalation.Results:in observation group,the blood oxygen saturation, symptoms and signs disappeared time,the cure rate is bet er than that in control group (P <0.01).Conclusion:oxygen aerosol inhalation in the treatment of infantile capil ary bronchitis meth-od is bet er than that of ultrasonic atomization inhalation,can shorten the course of the disease,relieve pain,children promote children recover at an early date,is worth promoting.%目的:探讨氧气驱动雾化吸入治疗小儿毛细支气管炎的疗效和护理。方法:将126例毛细支气管炎患儿随机分为观察组和对照组。对照组62例采用常规综合治疗,运用传统的超声雾化吸入方式。观察组64例在常规综合治疗的基础上,给予由氧气驱动雾化吸入方式。结果:观察组在血氧饱和度、症状及体征消失时间、治愈率等方面优于对照组(P <0.01)。结论:氧气驱动雾化吸入治疗小儿毛细支气管炎的方法优于超声雾化吸入方式,可缩短病程,减轻患儿痛苦,促进患儿早日康复,值得推广。

  1. The Applied Research on Ambroxol Hydrochloride in the Treatment of Bronchitis%盐酸氨溴索在支气管炎治疗中的应用研究

    Institute of Scientific and Technical Information of China (English)

    邢君

    2015-01-01

    Objective The treatment method and treatment effect of Ambroxol Hydrochloride in the treatment of Bronchitis is to be analyzed. Methods Choose 86 patients with bronchitis who are treated in hospital from April 2013 to July 2014 and separate them into study group and control group at random, 48 patients in study group are given Ambroxol Hydrochloride treatment, while 38 patients in control group are given bishuping medicine treatment, and then observe patients’ recovery state after treatment. Results The efficiency rate in study group is up to 93.75%, and in control group it is 81.58%;there is a great differential between two groups, which has the statistic value(P<0.05). Conclusion To cure patients with bronchitis, Ambroxol Hydrochloride treatment is quite effective to relieve patients’ symptoms and al eviate the pain.%目的:探究支气管炎患者采用盐酸氨溴索治疗的方法和效果。方法选取2013年4月~2014年7月收治的86例气管炎患者进行治疗,随机分组,实验组48例患者选择盐酸氨溴索的治疗,对照组38例患者选择必漱平的治疗,观察患者治疗后的身体情况。结果实验组治疗有效率为93.75%,对照组治疗有效率为81.58%。两组患者的治疗效果差异显著,有统计学意义(P<0.05)。结论支气管炎患者采用盐酸氨溴索的治疗,可明显缓解身体症状,减轻患者的痛苦,疗效显著。

  2. Curative effect observation of Sai Nuo Jin atomization inhalation in the treatment of capillary bronchitis%赛诺金雾化吸入治疗毛细支气管炎的疗效观察

    Institute of Scientific and Technical Information of China (English)

    王玉梅

    2015-01-01

    Objective:To observe the clinical curative effect of Sai Nuo Jin oxygen driven atomization inhalation in the treatment of capillary bronchitis.Methods:160 children with capillary bronchitis were selected from July 2012 to December 2013.They were randomly divided into the treatment group and the control group with 80 cases in each.The control group were given anti infection, pyretolysis,preventing phlegm from forming and stopping coughing,antispasmodic asthma,oxygen,cardiac and other treatments. The treatment group were given Sai Nuo Jin oxygen driven atomization inhalation treatment on the basis of the control group.The signs,symptoms and pulmonary rales situation of children in two groups were observed and recorded.Results:The total effective rate of the treatment group was 95.56%;the total effective rate of the control group was 78.57%;the difference was statistically significant(P<0.05).Conclusion:Sai Nuo Jin oxygen driven atomization inhalation in the treatment of capillary bronchitis has obvious effect.It is worth clinical promotion.%目的:观察赛诺金氧驱动雾化吸入治疗毛细支气管炎的临床疗效。方法:2012年7月-2013年12月收治毛细支气管炎患儿160例,随机分为治疗组和对照组,各80例,对照组给予抗感染、退热、化痰止咳、解痉平喘、吸氧、强心等治疗,治疗组在对照组的基础上加赛诺金氧驱动雾化吸入治疗,观察记录两组患儿症状、体征情况。结果:治疗组总有效率100%,对照组总有效率87.5%,差异有统计学意义(P<0.05)。结论:赛诺金氧驱动雾化治疗毛细支气管炎有明显效果,值得临床推广。

  3. 阿奇霉素治疗小儿喘息性支气管炎的临床效果观察%Clinical Effect of Azithromycin in the Treatment of Children with Asthmatic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    陈剑泓

    2014-01-01

    目的:探讨阿奇霉素治疗小儿喘息性支气管炎的临床效果。方法选取本院2O11年6月-2O13年6月收治的喘息性支气管炎患儿62例,随机分为对照组和观察组。两组均行常规治疗,观察组在此基础上给予阿奇霉素,比较两组临床效果。结果观察组总有效率(9O.32%)高于对照组(77.42%),差异有统计学意义( P bronchitis. Methods 62 cases of children with asthmatic bronchitis in the hospital from June 2O11 to June 2O13,were random-ly divided into control group and observation group. Two groups were treated with conventional therapy,and observation group was given Azithromycin based on this,the clinical effects were compared between the two groups. Results The curative effect of observation group(9O. 32% )was higher than control group(77. 42% ),the difference was statistically significant(P bronchitis is remarkable,safe and reliable,has the value of clinical ap-plication.

  4. 孟鲁斯特治疗小儿喘息性支气管炎的临床观察%Clinical Observation of Montelukast in the Treatment of Children With Asthmatic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    魏晓峰

    2016-01-01

    目的:探讨孟鲁斯特治疗小儿喘息性支气管炎的时效性。方法我院2013年5月~2015年4月确诊的小儿喘息性支气管炎患儿62例,均给予常规治疗。观察组睡前口服孟鲁司特,对照组睡前口服安慰剂。结果观察组喘息症状缓解时间(t=6.416,P=0.00)、肺部哮鸣音和啰音消失时间(t=4.190,P=0.00)、平均住院天数(t=4.111,P=0.00)短于对照组,疗效优于对照组(χ2=6.7721,P=0.0338)。结论孟鲁司特钠可加速喘息性支气管炎患儿的症状和体征的改善,提高临床效果。%Objective To investigate the effectiveness of montelukast in the treatment of children with asthmatic bronchitis. Methods 62 cases of children with asthmatic bronchitis in our hospital from May 2013 to April 2015 were treated with routine treatment. The observation group was oral before bedtime, and the control group received placebo before bedtime. Results In the observation group,the asthmatic symptoms remission time(t=6.416, P=0.00),pulmonary wheezing sound tone and rales disappearance time(t=4.190,P=0.00),the average hospitalization days(t=4.111,P=0.00) shorter than the control group,the curative effect was better than that of the control group(χ 2=6.772 1,P=0.033 8). Conclusion The effect of the improvement of the symptoms and signs of the patients with acute wheezing bronchitis can be improved by the conclusion of the conclusion.

  5. 匹多莫德佐治喘息性支气管炎的疗效评价%Curative effect evaluation of pidotimod in adjunctive treatment of asthmatic bronchitis

    Institute of Scientific and Technical Information of China (English)

    钟美雄; 黄敏宜; 陆桂宁

    2014-01-01

    Objective To evaluate the curative effect of pidotimod in adjunctive treatment of asthmatic bronchitis. Methods A total of 90 children with asthmatic bronchitis were randomly divided into control group and observation group, with 45 cases in each group. The control group received conventional treatment, and the observation group received additional pidotimod treatment. The curative effects of the two groups were compared. Results The cure time and antibiotics using time in the observation group were shorter than those in the control group, and the differences had statistical significance (P<0.01 or P<0.05). The total effective rate of the observation group was 97.78%, which was higher than 57.78%of the control group, and the difference had statistical significance (P<0.01). Conclusion Pidotimod can provide good curative effect in adjunctive treatment of pediatric asthmatic bronchitis, and it is worth clinical promotion.%目的:评价匹多莫德佐治喘息性支气管炎的疗效。方法90例喘息性气管炎患儿,随机分为对照组和观察组,各45例。对照组采用常规治疗方法,观察组在常规治疗基础上联合匹多莫德治疗,比较两组的治疗效果。结果观察组治愈时间、抗生素使用时间短于对照组,差异具有统计学意义(P<0.01或P<0.05);观察组总有效率97.78%高于对照组总有效率57.78%,差异具有统计学意义(P<0.01)。结论匹多莫德佐治小儿喘息性支气管炎疗效显著,值得临床推广。

  6. 过敏原检测对小儿毛细支气管炎的临床意义探讨%clinical significance discussion of allergen detection to infantile capillary bronchitis

    Institute of Scientific and Technical Information of China (English)

    彭俊云; 吴赞开; 陆国伟; 李裕昌

    2013-01-01

    目的:探讨研究过敏原检测,对于小儿毛细支气管炎的临床意义。方法:选取我院儿科确诊的21例毛细支气管炎患儿作为观察组,同期住院的其他患儿21例作为对照组,均进行血清特异性IgE检测。通过两组患儿的血清特异性IgE水平以及随访3个月后的喘息发生率比较两组检测结果的意义。结果:观察组患儿血清特异性IgE水平显著高于对照组(P<0.05),随访3个月后观察组患儿喘息发生率高于对照组,差异有显著性(P<0.05)。结论:对毛细支气管炎患儿进行过敏原检测,可有效预测病情的严重程度和转归,有利于避开相关的触发因素,预防反复喘息发作甚至哮喘发生。%Objective:to explore the allergen detection, for the clinical significance of children capillary bronchitis. Selection. Methods:our hospital pediatric diagnosis of 21 cases of capillary bronchitis patients as observation group, other children in 21 cases as control group, both detection of serum specific IgE. Through two groups of children with serum specific IgE levels and followed up for 3 months after the incidence of breathing is the meaning of two groups of test results.Results:the observation group had a significantly higher serum specific IgE levels in children with the control group (P<0.05), the observation group were followed up for 3 months after children breathing rate is higher than the control group, with significant difference (P<0.05). Conclusions:children with capillary bronchitis is used to detect the allergen, which can effectively predict the severity of the illness, and outcome, to avoid trigger factors and prevention of recurrent wheeze and asthma.

  7. 氨溴特罗治疗儿童急性支气管炎临床观察%Therapeutic Effect of Ambroxol and Clenbuterol Oral Solutions on Acute Bronchitis in Children

    Institute of Scientific and Technical Information of China (English)

    吴启富

    2012-01-01

    目的:探讨氨溴特罗口服液治疗儿童急性支气管炎的效果.方法:300例急性支气管炎患儿随机分成两组各150例.两组均在控制感染的基础上,治疗组口服氨溴特罗,对照组口服复方福尔可定,疗程5 d.观察两组临床疗效、不良反应和依从性.结果:治疗5 d后,治疗组总有效率(93.33%)明显高于对照组(84.67%),差异有统计学意义(P<0.05);咳嗽、痰量、痰黏稠度、喘息评分、不良反应发生率和依从性等方面比较,差异均有统计学意义(P<0.01或0.05).结论:氨溴特罗治疗急性支气管炎疗效显著,安全可靠,依从性好.%Objective: To evaluate the therapeutic effects of ambroxol and clenbuterol oral solutions on acute bronchitis in children. Method: Totally 300 cases with acute bronchitis were randomly divided into the treatment group ( 150 cases ) and the control group ( 150 cases). On the basis of anti-inflammatory therapy, ambroxol and clenbuterol oral solutions were given in the treatment group and pholcodine syrups were used in the control group for 5 days. The therapeutic effects, adverse reactions and compliance of the two groups were assessed. Result: After the treatment,the total effective rate of the treatment group( 93. 33% )was higher than that of the control group ( 84. 67% )( P<0. 05 ). The effects on cough,sputum volume,sputum viscosity and wheezing were much better in the treatment group than those in the control group( P<0. 01 ). There were significant statistic differences in the adverse reactions and compliance between the two groups( P<0. 05 ). Conclusion: Ambroxol and clenbuterol oral solutions are safe, convenient and highly effective in the treatment of acute bronchitis in children.

  8. 关于毛细支气管炎雾化吸入疗法的应用价值评价%About the Application of Capillary Bronchitis Atomization Inhalation Therapy Value Evaluation

    Institute of Scientific and Technical Information of China (English)

    高莉莉; 何朝晖

    2015-01-01

    Objective To study the method of atomizing inhalation in patients with infantile capil ary bronchitis application value. Methods Choose 102 cases of children with capil ary bronchitis, grouping according to the fol owing conditions:the parents refused to don't cooperate with atomization inhalation atomization inhalation or babies, conventional intravenous anti-infection, cough, phlegm, and symptomatic, a total of 34 cases, as control group. Team is divided into: group A for pure atomization inhalation, A total of 32 cases; Group B for symptomatic treatment with oral drug aerosol inhalation, a total of 36 cases. The general clinical information col ection. Results In the treatment of 3 days, evaluate the ef ect of three groups, found the team's condition, the significantly higher than the control group; Group A and group B of the clinical symptoms and signs disappeared time has no obvious dif erence, the dif erence was statistical y significant; ( < 0.05). Conclusion atomization inhalation method is an ef ective method of capil ary bronchitis.%目的:探讨雾化吸入法在小儿毛细支气管炎患者中的应用价值。方法选取患有毛细支气管炎的患儿102例,根据如下情况分组:家长拒绝雾化吸入或婴儿不配合雾化吸入的,常规静脉抗感染,止咳、化痰及对症的,共34例,作为对照组。研究组分为:A组为单纯雾化吸入,共32例;B组为口服药物对症治疗上加用雾化吸入,共36例。收集一般临床资料。结果在治疗第3d,对3组疗效进行评价,发现研究组病情好转率明显高于对照组;A组与B组的临床症状、体征消失时间无明显的差异性,差异有统计学意义(<0.05)。结论雾化吸入法是治疗毛细支气管炎的一种有效的方法。

  9. Watercress Formula for Chicken Kidney Type Infectious Bronchitis%荆芥组方对鸡肾型传染性支气管炎防治效果观察

    Institute of Scientific and Technical Information of China (English)

    冯善祥

    2011-01-01

    We used the method of randomization and duplication of pathological model to do this research. In order to validate the effects of the compound preparation of Chinese traditional medicine to the avian infectious bronchitis, we divided the 2-week-old AA kreo-chicken into 8 groups (30 chicken for each group), including the investigational drug groups (which include the high dose group and the moderate dose group as well as the low dose group) and the following control groups: the control group of traditional Chinese medicine and the Western medicine group, the vaccine control group and the negative control group as well as the health control group. The chickens were artificially infected with infectious bronchitis virus (IBV) to observe the protection of the compound preparation of Chinese traditional medicine. The results indicated that the compound preparation of Chinese traditional medicine has a great protection to chicken infected by (IBV). Therefore, the compound preparation of Chinese traditional medicine can be used to the prevention and cure of avian infectious bronchitis.%本试验采取随机分组,病理模型复制的方法,试验中将14日龄AA肉雏鸡240只随机分为受试药物组(高、中、低3个剂量)、中药对照组、西药对照组、疫苗对照组、阴性对照组、健康对照组共8个组,每组30只,以验证中药荆芥组方对鸡肾型传染性支气管炎的效果.将试验鸡人T感染肾型传染性支气管炎病毒(IBV),观察中药组方对雏鸡保护作用.结果表明,本组方对肾型传染性支气管炎病毒感染雏鸡具有明显的保护作用,可以用于鸡肾型传染性支气管炎的预防和治疗.

  10. Coping with Chronic Illness

    Science.gov (United States)

    Having a long-term, or chronic, illness can disrupt your life in many ways. You may often be tired and in pain. Your illness might affect your ... able to work, causing financial problems. For children, chronic illnesses can be frightening, because they may not ...

  11. Chronic Postoperative Roseomonas Endophthalmitis▿

    OpenAIRE

    Chen, Kuan-Jen; Lai, Chi-Chun; Kuo, Ya-Hui; WU, WEI-CHI; CHEN, TUN-LU

    2008-01-01

    We report one case with chronic postoperative endophthalmitis caused by Roseomonas species. Roseomonas spp. induced chronic endophthalmitis, which might result in misdiagnosis and delayed treatment and causes ocular damage and severe visual loss. This report is the first one related to a case with postoperative endophthalmitis secondary to Roseomonas infection.

  12. Chronic postoperative Roseomonas endophthalmitis.

    Science.gov (United States)

    Chen, Kuan-Jen; Lai, Chi-Chun; Kuo, Ya-Hui; Wu, Wei-Chi; Chen, Tun-Lu

    2009-01-01

    We report one case with chronic postoperative endophthalmitis caused by Roseomonas species. Roseomonas spp. induced chronic endophthalmitis, which might result in misdiagnosis and delayed treatment and causes ocular damage and severe visual loss. This report is the first one related to a case with postoperative endophthalmitis secondary to Roseomonas infection.

  13. [Chronic pancreatitis, acute pancreatitis].

    Science.gov (United States)

    Mabuchi, T; Katada, N; Nishimura, D; Hoshino, H; Shimizu, F; Suzuki, R; Sano, H; Kato, K

    1998-11-01

    MRCP has been recognized as a safe and noninvasive diagnostic method. In the present study we evaluated the usefulness of MRCP in diagnosis of chronic and acute pancreatitis. Two-dimensional fast asymmetric spin-echo (FASE) MRCP was performed in 40 patients with chronic pancreatitis and 13 with acute pancreatitis. In 29 patients (72.5%) with chronic pancreatitis and 9 (66.7%) with acute pancreatitis, main pancreatic duct (MPD) was visualized entirely. MRCP could demonstrate the characteristic findings of chronic pancreatitis such as dilatation and irregularity of MPD in most cases. In acute pancreatitis, MRCP indicated that MPD was normal in diameter, but irregular in configuration compared with that of the control group. MRCP may facilitate the diagnosis of chronic and acute pancreatitis.

  14. The Chronic Responsibility

    DEFF Research Database (Denmark)

    Ravn, Iben M; Frederiksen, Kirsten; Beedholm, Kirsten

    2016-01-01

    This article reports on the results of a Fairclough-inspired critical discourse analysis aiming to clarify how chronically ill patients are presented in contemporary Danish chronic care policies. Drawing on Fairclough’s three-dimensional framework for analyzing discourse, and using Dean’s concepts...... of governmentality as an interpretative lens, we analyzed and explained six policies published by the Danish Health and Medicines Authority between 2005 and 2013. The analysis revealed that discourses within the policy vision of chronic care consider chronically ill patients’ active role, lifestyle, and health...... behavior to be the main factors influencing susceptibility to chronic diseases. We argue that this discursive construction naturalizes a division between people who can actively manage responsible self-care and those who cannot. Such discourses may serve the interests of those patients who are already...

  15. Chronic gastritis - an update.

    Science.gov (United States)

    Varbanova, Mariya; Frauenschläger, Katrin; Malfertheiner, Peter

    2014-12-01

    Helicobacter pylori is the main aetiologic factor for chronic gastritis worldwide. The degree of inflammation and the evolution of this form of chronic gastritis can vary largely depending on bacterial virulence factors, host susceptibility factors and environmental conditions. Autoimmune gastritis is another cause of chronic inflammation in the stomach, which can occur in all age groups. This disease presents typically with vitamin B12 deficiency and pernicious anaemia. The presence of anti-parietal cell antibodies is highly specific for the diagnosis. The role of H. pylori as a trigger for autoimmune gastritis remains uncertain. Other rare conditions for chronic gastritis are chronic inflammatory conditions such as Crohn's disease or on the background of lymphocytic or collagenous gastroenteropathies.

  16. Chronic granulomatous disease associated with chronic glomerulonephritis

    DEFF Research Database (Denmark)

    Frifelt, J J; Schønheyder, Henrik Carl; Valerius, Niels Henrik

    1985-01-01

    A boy with chronic granulomatous disease (CGD) developed glomerulonephritis at the age of 12 years. The glomerulonephritis progressed to terminal uraemia at age 15 when maintenance haemodialysis was started. The clinical course was complicated by pulmonary aspergillosis and Pseudomonas septicaemia...... from which he eventually died. The glomerulonephritis was of unknown origin, and a possible relationship between CGD and glomerulonephritis is discussed....

  17. What Is Chronic Myeloid Leukemia?

    Science.gov (United States)

    ... Chronic Myeloid Leukemia (CML) About Chronic Myeloid Leukemia What Is Chronic Myeloid Leukemia? Cancer starts when cells ... their treatment is the same as for adults. What is leukemia? Leukemia is a cancer that starts ...

  18. What Is Chronic Lymphocytic Leukemia?

    Science.gov (United States)

    ... Chronic Lymphocytic Leukemia (CLL) About Chronic Lymphocytic Leukemia What Is Chronic Lymphocytic Leukemia? Cancer starts when cells ... body, including the lymph nodes, liver, and spleen. What is leukemia? Leukemia is a cancer that starts ...

  19. Observation of curative effect of Xiyanping on treating capillarity bronchitis%喜炎平治疗毛细支气管炎60例疗效观察

    Institute of Scientific and Technical Information of China (English)

    马洪英; 唐毅

    2011-01-01

    目的 现察喜炎平对毛细支气管炎的治疗效果.方法 将120例毛细支气管炎患者随机分为治疗组与对照组,每组均为60例,两组患者在吸氧、祛痰的基础上,治疗组用喜炎平治疗,对照组用病毒唑治疗,根据治疗效果进行对比分析.结果 治疗组在发热、喘憋、肺部罗音消失时间缩短等方面优于对照组,差异有显著性(P<0.05).结论 喜炎平抗病毒作用比病毒唑强,治疗毛细支气管炎取得满意疗效,值得临床推广.%Objective To observe Xiyanping's curative effect on capillarity bronchitis. Methods 120 cases with capillarity bronchitis were stochastically divided into two groups, including the treatment group ( 60 cases) and the control group (60 cases). Based on oxygen- breathing and phlegm dispelling, the treatment group was treated with Xiyanping, while the control group with ribavirin. Results The result indicates that the vanishing time for Xiyanping group's fever, suppression of heavy breath and lungs Rales were reduced. Conclusion Xiyanping's anti-virus function is stronger than ribavirin.

  20. The Clinical Research of Montelukast Sodium for the Treatment of Pediatric Asthmatic Bronchitis%应用孟鲁司特钠治疗小儿喘息性支气管炎的临床研究

    Institute of Scientific and Technical Information of China (English)

    刘金联

    2015-01-01

    ObjectiveTo investigate the clinical effect of application of montelukast sodium in treatment of children with asthmatic bronchitis. MethodsTo our hospital for 76 children with asthmatic bronchitis patients treated cases selected in accordance with the different treatment methods for the observation group and the control group, patients in the control group using conventional methods of treatment, patients in the observation group based on the treatment in control group were treated with montelukast sodium.Results After treatment, the patients in observation group were signiifcantly better than the treatment effect of patients in the control group, P<0.05.Conclusion The addition of montelukast sodium in the process of traditional therapy in treatment can signiifcantly improve the treatment effect.%目的探讨应用孟鲁司特钠治疗小儿喘息性支气管炎的临床治疗效果。方法选取来我院进行治疗的小儿喘息性支气管炎患者76例,按照治疗方式的不同分为对照组和观察组,对照组患者使用常规方式进行治疗,观察组患者在对照组治疗的基础上加用孟鲁司特钠进行治疗。结果经过治疗后,观察组患者的治疗效果明显优于对照组患者, P<0.05。结论在传统治疗的过程中加入孟鲁司特钠进行治疗能够明显提高治疗的效果。

  1. Mathematical model of mean age, mean arsenic dietary dose and age-specific prevalence rate from endemic chronic arsenic poisoning: a human toxicology study

    Energy Technology Data Exchange (ETDEWEB)

    Zald' ivar, R.; Ghai, G.L.

    1980-01-01

    The aim of this investigation was to develop a mathematical model of mean age, mean arsenic dietary dose, and age-specific prevalence rate for endemic chronic arsenic poisoning. Data on mean age (years), mean arsenic dietary dose (mg/kg body weight/day), and age-specific prevalence rate per 100,000 population for endemic chronic arsenic poisoning in Antofagasta Commune, northern Chile, for the 1968 to 1971 period, were collected. Endemic chronic arsenic poisoning means here chronic arsenical dermatosis associated with marked or sever symptoms (or signs) of chronic arsenic poisoning (chronic diarrhea, hepatic cirrohsis, chronic bronchitis, bronchiectasis, recurrent broncho-pneumonia, cardiomegaly, systemic occlusive arterial disease, cerebral thrombosis, etc.). There was a strong positive correlation between age-specific pevalence rate per 100,000 population and mean arsenic dose (r = + 0.9593) and a negative correlation between prevalence rate and mean age (r = 0.8789). These findings show that the prevalence rate declines with the advancing age and increases with the increase of arsenic dose. A multiple linear regression model E(y) = alpha + beta X1 + gamma X2, where y represents the age-specific prevalence rate per 100,000 population, X1 the mean arsenic dose, and X2 the mean age, was fitted to the data. The estimates of the parameters (alpha, beta, and gamma) were obtained by minimizing the residual sum of squares sigma(y - alpha - beta X1 - gamma X2)2. The following multiple linear regression equation was obtained: Y = 202.161 + 8452.455 X1 - 2.394 X2. Of the total variability in the prevalence rate, 96.22 percent was accounted for by the multiple regression.

  2. Chronic hypersensitivity pneumonitis

    Science.gov (United States)

    Pereira, Carlos AC; Gimenez, Andréa; Kuranishi, Lilian; Storrer, Karin

    2016-01-01

    Hypersensitivity pneumonitis (HSP) is a common interstitial lung disease resulting from inhalation of a large variety of antigens by susceptible individuals. The disease is best classified as acute and chronic. Chronic HSP can be fibrosing or not. Fibrotic HSP has a large differential diagnosis and has a worse prognosis. The most common etiologies for HSP are reviewed. Diagnostic criteria are proposed for both chronic forms based on exposure, lung auscultation, lung function tests, HRCT findings, bronchoalveolar lavage, and biopsies. Treatment options are limited, but lung transplantation results in greater survival in comparison to idiopathic pulmonary fibrosis. Randomized trials with new antifibrotic agents are necessary. PMID:27703382

  3. Expression profiles of hydrophobic surfactant proteins in children with diffuse chronic lung disease

    Directory of Open Access Journals (Sweden)

    Guttentag Susan

    2005-07-01

    Full Text Available Abstract Background Abnormalities of the intracellular metabolism of the hydrophobic surfactant proteins SP-B and SP-C and their precursors may be causally linked to chronic childhood diffuse lung diseases. The profile of these proteins in the alveolar space is unknown in such subjects. Methods We analyzed bronchoalveolar lavage fluid by Western blotting for SP-B, SP-C and their proforms in children with pulmonary alveolar proteinosis (PAP, n = 15, children with no SP-B (n = 6, children with chronic respiratory distress of unknown cause (cRD, n = 7, in comparison to children without lung disease (n = 15 or chronic obstructive bronchitis (n = 19. Results Pro-SP-B of 25–26 kD was commonly abundant in all groups of subjects, suggesting that their presence is not of diagnostic value for processing defects. In contrast, pro-SP-B peptides cleaved off during intracellular processing of SP-B and smaller than 19–21 kD, were exclusively found in PAP and cRD. In 4 of 6 children with no SP-B, mutations of SFTPB or SPTPC genes were found. Pro-SP-C forms were identified at very low frequency. Their presence was clearly, but not exclusively associated with mutations of the SFTPB and SPTPC genes, impeding their usage as candidates for diagnostic screening. Conclusion Immuno-analysis of the hydrophobic surfactant proteins and their precursor forms in bronchoalveolar lavage is minimally invasive and can give valuable clues for the involvement of processing abnormalities in pediatric pulmonary disorders.

  4. Chronic Fatigue Syndrome

    Science.gov (United States)

    Chronic fatigue syndrome (CFS) is a disorder that causes extreme fatigue. This fatigue is not the kind of tired feeling that ... activities. The main symptom of CFS is severe fatigue that lasts for 6 months or more. You ...

  5. Chronic Kidney Disease

    Science.gov (United States)

    You have two kidneys, each about the size of your fist. Their main job is to filter wastes and excess water out of ... help control blood pressure, and make hormones. Chronic kidney disease (CKD) means that your kidneys are damaged ...

  6. Chronic sinusitis (image)

    Science.gov (United States)

    ... and cartilage and lined with a mucous membrane. Sinusitis occurs when the membranes becomes inflamed and painful, ... a result of a blocked sinus opening. Chronic sinusitis is often caused by inflammation and blockage due ...

  7. Chronic Condition Data Warehouse

    Data.gov (United States)

    U.S. Department of Health & Human Services — The CMS Chronic Condition Data Warehouse (CCW) provides researchers with Medicare and Medicaid beneficiary, claims, and assessment data linked by beneficiary across...

  8. Chronic Critical Illness

    Science.gov (United States)

    ... the patient’s situation and on the hospital and city. Do Chronically Critically Ill Patients Regain the Ability ... as the patient. You may feel stress, worry, sadness, or fatigue. Some families worry about financial burdens. ...

  9. Chronic Conditions Dashboard

    Data.gov (United States)

    U.S. Department of Health & Human Services — The CMS Chronic Conditions Dashboard presents statistical views of information on the prevalence, utilization and Medicare spending for Medicare beneficiaries with...

  10. Chronic Myeloproliferative Neoplasms Treatment

    Science.gov (United States)

    ... way to treat some chronic myeloproliferative neoplasms. Platelet apheresis Platelet apheresis is a treatment that uses a special machine ... using interferon alfa or pegylated interferon alpha . Platelet apheresis . A clinical trial of a new treatment. Check ...

  11. Chronic penile strangulation

    Directory of Open Access Journals (Sweden)

    Lopes Roberto I

    2003-01-01

    Full Text Available Chronic penile strangulation is exceedingly rare with only 5 cases previously reported. We report an additional case of progressive penile lymphedema due to chronic intermittent strangulation caused by a rubber band applied to the penile base for 6 years. A 49-year-old man presented incapacity to exteriorize the glans penis. For erotic purposes, he had been using a rubber-enlarging band placed in the penile base for 6 years. With chronic use, he noticed that his penis swelled. Physical examination revealed lymphedema of the penis, phimosis and a stricture in the penile base. The patient was submitted to circumcision and the lymphedema remained stable 10 months postoperatively. Chronic penile incarceration usually causes penile lymphedema and urinary disturbance. Treatment consists of removal of foreign devices and surgical treatment of lymphedema.

  12. Chronic Illness & Mental Health

    Science.gov (United States)

    ... is present. For More Information Share Chronic Illness & Mental Health Download PDF Download ePub Order a free hardcopy ... For more information, see the National Institute of Mental Health (NIMH) booklet on Depression at http://www.nimh. ...

  13. Chronic obstructive pulmonary disease

    Science.gov (United States)

    ... and oxygen therapy Right-sided heart failure or cor pulmonale (heart swelling and heart failure due to chronic ... PA: Elsevier Saunders; 2016:chap 44. Read More Cor pulmonale Dilated cardiomyopathy Heart failure - overview Lung disease Patient ...

  14. Chronic Kidney Disease (CKD)

    Science.gov (United States)

    ... CKD treated? Kidney-friendly diet for CKD What causes chronic kidney disease (CKD)? Anyone can get CKD. Some people are ... and high blood pressure are the most common causes of CKD. If you have diabetes or high blood pressure, ...

  15. Sleep and Chronic Disease

    Science.gov (United States)

    ... message, please visit this page: About CDC.gov . Sleep About Us About Sleep Key Sleep Disorders Sleep ... Sheets Data & Statistics Projects and Partners Resources Events Sleep and Chronic Disease Recommend on Facebook Tweet Share ...

  16. Chronic Conditions PUF

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Chronic Conditions PUFs are aggregated files in which each record is a profile or cell defined by the characteristics of Medicare beneficiaries. A profile is...

  17. Chronic inflammatory demyelinative polyneuropathy

    DEFF Research Database (Denmark)

    Said, Gérard; Krarup, Christian

    2013-01-01

    Chronic inflammatory demyelinative polyneuropathy (CIDP) is an acquired polyneuropathy presumably of immunological origin. It is characterized by a progressive or a relapsing course with predominant motor deficit. The diagnosis rests on the association of non-length-dependent predominantly motor ...

  18. Chronic dysimmune neuropathies: Beyond chronic demyelinating polyradiculoneuropathy

    Directory of Open Access Journals (Sweden)

    Khadilkar Satish

    2011-01-01

    Full Text Available The spectrum of chronic dysimmune neuropathies has widened well beyond chronic demyelinating polyradiculoneuropathy (CIDP. Pure motor (multifocal motor neuropathy, sensorimotor with asymmetrical involvement (multifocal acquired demylinating sensory and motor neuropathy, exclusively distal sensory (distal acquired demyelinating sensory neuropathy and very proximal sensory (chronic immune sensory polyradiculopathy constitute the variants of CIDP. Correct diagnosis of these entities is of importance in terms of initiation of appropriate therapy as well as prognostication of these patients. The rates of detection of immune-mediated neuropathies with monoclonal cell proliferation (monoclonal gammopathy of unknown significance, multiple myeloma, etc. have been facilitated as better diagnostic tools such as serum immunofixation electrophoresis are being used more often. Immune neuropathies associated with malignancies and systemic vasculitic disorders are being defined further and treated early with better understanding of the disease processes. As this field of dysimmune neuropathies will evolve in the future, some of the curious aspects of the clinical presentations and response patterns to different immunosuppressants or immunomodulators will be further elucidated. This review also discusses representative case studies.

  19. Tolerance and chronic rejection.

    OpenAIRE

    Womer, K. L.; Lee, R S; Madsen, J. C.; Sayegh, M H

    2001-01-01

    The most common cause of chronic allograft loss is an incompletely understood clinicopathological entity called chronic rejection (CR). Recent reports suggest an improvement in long-term renal allograft survival, although it is not clear from these data whether a true reduction of biopsy-proven CR has occurred. Although newer immunosuppressive medications have greatly reduced the incidence of acute rejection (AR) in the early post-transplantation period, the ideal therapy for both AR and CR w...

  20. Chronic obstructive pulmonary disease

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    2008430 Effect of gas exchange at maximal intensity on exercise capacity in patients with chronic obstructive pulmonary disease. WANG Haoyan(王浩彦), et al. Dept Respir Dis, Beijing Friendship Hosp, Capital Med Sci Univ, Beijing 100050. Chin J Tuberc Respir Dis 2008;31(6):414-416. Objective To investigate the effect of gas exchange at maximal intensity on exercise capacity in patients with chronic obstructive pulmonary disease (COPD).

  1. Experimental chronic periodontitis morphogenesis

    OpenAIRE

    Schneider S.A.

    2011-01-01

    Morphogenesis of periodontium tissue in a model of chronic periodontitis was studied. Adult Wistar rats wereused in a model; chronic periodontitis was developed through mastication-related loading decrease. Histological assessmentof periodontium tissue was conducted at Days 7, 14, 21 and 30. It was demonstrated that dystrophic tissue changes prevailover the inflammatory one in this particular experimental model. The structural elements of periodontium were involved intothe pathologic process ...

  2. Understanding chronic heart failure

    OpenAIRE

    Fenton, Matthew; Burch, Michael

    2007-01-01

    The key principles of chronic heart failure and the development of clinical management strategies are described. The physiological changes in chronic heart failure and the clinical management of children with heart failure are considered, but the treatment of heart failure related to congenital heart disease or the intensive care management of heart failure are not mentioned as both topics require consideration in their own right. A greater understanding of the maladaptive responses to chroni...

  3. [Effect of rehabilitation using antihomotoxic drug together with energy stabilizing electromagnetic therapy on morphological, biochemical, and system immunity indices in children with recurrent bronchitis].

    Science.gov (United States)

    Lyseniuk, V P; Naumova, M I; Shapoval, V N

    2012-01-01

    There is now good evidence that the use of electromagnetic millimeter waves the following curative effects: analgesic, normalization of relations or increased formation of neurohumoral substances. The introduction of a therapeutic practice complex biological drugs that trigger, not overwhelming the body auxiliary immunological reaction, based on the activation of the regulation clones of T-lymphocytes and helper functions, is an important step in achieving a qualitatively level of health patients with chronic disease.

  4. Treatment of Chronic Cough.

    Science.gov (United States)

    Soni, Resha S; Ebersole, Barbara; Jamal, Nausheen

    2017-01-01

    Objective Chronic cough remains a challenging condition, especially in cases where it persists despite comprehensive medical management. For these particular patients, there appears to be an emerging role for behavior modification therapy. We report a series of patients with refractory chronic cough to assess if there is any benefit of adding behavioral therapy to their treatment regimen. Study Design A case series with planned chart review of patients treated for chronic cough. Setting The review was performed with an outpatient electronic health record system at a tertiary care center. Subjects and Methods The charts of all patients treated for chronic cough by a single laryngologist over a 30-month period were analyzed. Patients' response to treatment and rate of cough improvement were assessed for those with refractory chronic cough who underwent behavior modification therapy. Results Thirty-eight patients with chronic cough were initially treated empirically for the most common causes of cough, of which 32% experienced improvement. Nineteen patients who did not significantly improve with medical management underwent behavior modification therapy with a speech-language pathologist. Of these patients, 84% experienced resolution or marked improvement of their symptoms. Conclusion Behavioral therapy may be underutilized in practice and could lead to improvement of otherwise recalcitrant cough.

  5. 厄多司坦胶囊对慢性支气管炎祛痰疗效的临床研究%Clinical Sdudy on Apophlegmatic Efficacy of Erdosteine Capsule for Treatment of Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    刘进; 王选锭; 刘富光; 钮善福; 周建英

    2002-01-01

    目的:评价厄多司坦胶囊对慢性支气管炎的祛痰疗效及其安全性.方法:采用随机对照、双盲双模拟试验方法.以安溴索(ambroxo1)片作对照药,对比研究厄多司坦胶囊对慢性支气管炎祛痰的临床疗效和安全性.试验组105例,厄多司坦胶囊300mg,每日二次;对照组93例,安溴索片30mg,每日三次;两组疗程7~10d.结果:试验组与对照组临床疗效分别为57.1%和58.1%;祛痰疗效有效率分别为83.8%与83.9%;综合临床疗效(临床疗效与祛痰疗效的结合)有效率分别为60.0%与60.2%.药物不良反应发生率试验组与对照组分别为8.6%与54%.两组有效率和不良反应发生率比较均无统计学差异.结论:厄多司坦胶囊对慢性支气管炎咳嗽、咳痰的临床疗效明显,特别是痰液粘稠、排痰困难患者其祛痰疗效确切,使用安全.

  6. Chronic respiratory diseases and risk factors in 12 regions of the Russian Federation

    Directory of Open Access Journals (Sweden)

    Chuchalin AG

    2014-09-01

    Full Text Available Alexander G Chuchalin,1 Nikolai Khaltaev,2 Nikolay S Antonov,1 Dmitry V Galkin,3 Leonid G Manakov,4 Paola Antonini,5 Michael Murphy,5 Alexander G Solodovnikov,6 Jean Bousquet,7 Marcelo HS Pereira,8 Irina V Demko9 1Institute of Pulmonology, Federal Medical and Biological Agency, Moscow, Russia; 2Global Alliance Against Chronic Respiratory Diseases (GARD, Genève, Switzerland; 3GlaxoSmithKline, Moscow, Russia; 4Far Eastern Scientific Center of Physiology and Pathology of Respiration RAS (Russian Academy of Sciences, Blagoveshchensk, Russia; 5Worldwide Clinical Trials, King of Prussia, PA, USA; 6Worldwide Clinical Trials, Ekaterinburg, Russia; 7Institut National de la Santé et de la Recherche Médicale, Montpellier, France; 8Research and Development Chief Medical Office, International Medical, GlaxoSmithKline, London, United Kingdom; 9Krasnoyarsk State Medical University, Krasnoyarsk, Russia Background: Estimation suggests that at least 4 million people die, annually, as a result of chronic respiratory disease (CRD. The Global Alliance against Chronic Respiratory Diseases (GARD was formed following a mandate from the World Health Assembly to address this serious and growing health problem. Objectives: To investigate the prevalence of CRD in Russian symptomatic patients and to evaluate the frequency of major risk factors for CRD in Russia. Methods: A cross-sectional, population-based epidemiological study using the GARD questionnaire on adults from 12 regions of the Russian Federation. Common respiratory symptoms and risk factors were recorded. Spirometry was performed in respondents with suspected CRD. Allergic rhinitis (AR and chronic bronchitis (CB were defined by the presence of related symptoms according to the Allergic Rhinitis and its Impact on Asthma and the Global Initiative for Obstructive Lung Disease guidelines; asthma was defined based on disease symptoms; chronic obstructive pulmonary disease (COPD was defined as a post

  7. HIGH-Resolution CT in Chronic Pulmonary Changes after Mustard Gas Exposure

    Energy Technology Data Exchange (ETDEWEB)

    Bagheri, M.H.; Mostafavi, S.H. [Shiraz Univ. of Medical Siences (Iran, Islamic Republic of). Dept. of Radiology; Hosseini, S.K. [Shiraz Univ. of Medical Siences (Iran, Islamic Republic of). Dept. of Internal Medicine; Alavi, S.A. [Medical Center for Chemical Warfare Victims Foundation, Shiraz (Iran, Islamic Republic of)

    2003-05-01

    Purpose: To identify the findings of high-resolution CT (HRCT) of the lung in patients with previous sulfur mustard gas exposure, and to correlate these findings with clinical and chest X-ray (CXR) results. Material and Methods: 50 consecutive patients were studied prospectively. The clinical data were recorded. Standard p.a. CXR and HRCT of the lung and spirometry were performed. The findings of CXR, HRCT and clinical and spirometry results were scored between 0 and 3 according to the severity of the findings. Results: HRCT abnormality was detected in all 50 patients (100%), while CXR was abnormal in 40 patients (80%). The most common HRCT findings was airway abnormalities (bronchial wall thickening in 100% of cases). Other important findings were suggestive of interstitial lung disease (ILD) (80%), bronchiectasis (26%), and emphysema (24%). A statistically significant correlation was found between the severity of clinical presentation and that of the HCTR scores in patients with bronchiectasis, bronchitis and ILD (p< 0.05), but not with severity scores of HRCT in patients with emphysema. No significant correlation was found between severity scores of CXR findings. HRCT evidence of bronchial wall thickening and with a lower frequency ILD were present despite normal CXR in 20% of the patients. Conclusion: The results of this study suggest that bronchial wall thickening, ILD and emphysema are common chronic pulmonary sequelae of sulfur mustard injury. HRCT of the chest should be considered as the imaging modality of choice in chemical war injury.

  8. 慢性咳嗽的相关疾病及其治疗现状%Related diseases and treatment status of chronic cough

    Institute of Scientific and Technical Information of China (English)

    徐俪颖; 骆仙芳; 王会仍

    2010-01-01

    This article classified the chronic cough by its properties of dry cough or wet cough and summarizes the etiology and pathogenesis,the diagnosis and differentiation as well as the treatment status of related diseases of chronic cough for clinical reference,such as cough variant asthma,eosinophilic bronchitis,gastro-esophageal reflux cough,upper airway cough syndrome,postinfectious cough,atopic cough,cough related by ACEI,psychogenic cough,chronic obstructive pulmonary disease and other organic pulmonary disease with low incidence of cough.%本文对慢性咳嗽干性或湿性的性质进行病因分类,并对咳嗽变异性哮喘、嗜酸粒细胞性支气管炎、胃食管反流性咳嗽、上呼吸道咳嗽综合征、感染后咳嗽、特应性咳嗽、血管紧张素转换酶抑制剂所致的咳嗽、心理性咳嗽、慢性阻塞性肺疾病及其他咳嗽发生率较少的器质性肺部疾病的病因病机、临床诊断和鉴别诊断及其治疗现状进行综述,以供临床参考.

  9. Chronic prostatitis: Current concepts

    Directory of Open Access Journals (Sweden)

    Ram Vaidyanathan

    2008-01-01

    Full Text Available Purpose: Chronic prostatitis (CP is a common condition. It causes significant suffering to the patients and constitutes a sizeable workload for the urologists. The purpose of this review is to describe the currently accepted concepts regarding the aspects of CP. Materials and Methods: Relevant papers on the epidemiology, etiology, diagnosis, evaluation and management of CP were identified through a search of MEDLINE using text terms "prostatitis", "chronic prostatitis" and "chronic pelvic pain syndrome". The list of articles thus obtained was supplemented by manual search of bibliographies of the identified articles and also by exploring the MEDLINE option "Related Articles". Results: The salient points of the relevant articles on each aspect of CP have been summarized in the form of a non-systematic narrative review. Conclusion: Chronic prostatitis is caused by a variety of infective and non-infective factors and is characterized by a rather long remitting and relapsing clinical course. The diagnosis is based on symptoms comprising pain and nonspecific urinary and/or ejaculatory disturbances and microbiological tests to localize bacteria and/or leucocytes in segmented urinary tract specimens. The contemporary classification was proposed by the National Institutes of Health/National Institute of Diabetes Digestive Kidney Diseases (NIH/NIDDK. National Institutes of Health - Chronic Prostatitis Symptom Index (NIH-CPSI is the patient evaluation tool used extensively in clinical practice and research. Management should be individualized, multimodal and of an appropriate duration.

  10. Autoantibodies in chronic pancreatitis

    DEFF Research Database (Denmark)

    Rumessen, J J; Marner, B; Pedersen, N T

    1985-01-01

    In 60 consecutive patients clinically suspected of having chronic pancreatitis the serum concentration of the immunoglobulins (IgA, IgG, IgM), the IgG- and IgA-type non-organ-specific autoantibodies against nuclear material (ANA), smooth and striated muscle, mitochondria, basal membrane, and reti......In 60 consecutive patients clinically suspected of having chronic pancreatitis the serum concentration of the immunoglobulins (IgA, IgG, IgM), the IgG- and IgA-type non-organ-specific autoantibodies against nuclear material (ANA), smooth and striated muscle, mitochondria, basal membrane......, and reticulin, and the IgG- and IgA-type pancreas-specific antibodies against islet cells, acinus cells, and ductal cells (DA) were estimated blindly. In 23 of the patients chronic pancreatitis was verified, whereas chronic pancreatitis was rejected in 37 patients (control group). IgG and IgA were found...... in significantly higher concentrations in the patients with chronic pancreatitis than in the control group but within the normal range. ANA and DA occurred very frequently in both groups but with no statistical difference. Other autoantibodies only occurred sporadically. The findings of this study do not support...

  11. Management of chronic paronychia

    Directory of Open Access Journals (Sweden)

    Vineet Relhan

    2014-01-01

    Full Text Available Chronic paronychia is an inflammatory disorder of the nail folds of a toe or finger presenting as redness, tenderness, and swelling. It is recalcitrant dermatoses seen commonly in housewives and housemaids. It is a multifactorial inflammatory reaction of the proximal nail fold to irritants and allergens. Repeated bouts of inflammation lead to fibrosis of proximal nail fold with poor generation of cuticle, which in turn exposes the nail further to irritants and allergens. Thus, general preventive measures form cornerstone of the therapy. Though previously anti-fungals were the mainstay of therapy, topical steroid creams have been found to be more effective in the treatment of chronic paronychia. In recalcitrant cases, surgical treatment may be resorted to, which includes en bloc excision of the proximal nail fold or an eponychial marsupialization, with or without nail plate removal. Newer therapies and surgical modalities are being employed in the management of chronic paronychia. In this overview, we review recent epidemiological studies, present current thinking on the pathophysiology leading to chronic paronychia, discuss the challenges chronic paronychia presents, and recommend a commonsense approach to management.

  12. Chronic daily headaches

    Directory of Open Access Journals (Sweden)

    Fayyaz Ahmed

    2012-01-01

    Full Text Available Chronic Daily Headache is a descriptive term that includes disorders with headaches on more days than not and affects 4% of the general population. The condition has a debilitating effect on individuals and society through direct cost to healthcare and indirectly to the economy in general. To successfully manage chronic daily headache syndromes it is important to exclude secondary causes with comprehensive history and relevant investigations; identify risk factors that predict its development and recognise its sub-types to appropriately manage the condition. Chronic migraine, chronic tension-type headache, new daily persistent headache and medication overuse headache accounts for the vast majority of chronic daily headaches. The scope of this article is to review the primary headache disorders. Secondary headaches are not discussed except medication overuse headache that often accompanies primary headache disorders. The article critically reviews the literature on the current understanding of daily headache disorders focusing in particular on recent developments in the treatment of frequent headaches.

  13. 三拗汤加味治疗治疗小儿支气管炎和肺炎%Modified Three Decoction Treatment of Children with Bronchitis and Pneumonia

    Institute of Scientific and Technical Information of China (English)

    陈玉琴

    2015-01-01

    目的:对应用加味三拗汤对患有支气管炎和肺炎疾病的患儿实施治疗的临床效果进行研究。方法整群选择在该院就诊的患有支气管炎和肺炎疾病的患儿88例,随机分为对照组和治疗组,平均每组44例。采用常规西药对对照组患儿实施治疗;在常规西药基础上加用加味三拗汤对治疗组患儿实施治疗。结果治疗组患儿体温水平恢复正常时间(3.03±0.54)d、喘咳症状彻底消失时间(5.10±0.62)d、呼吸功能指标恢复正常时间(6.24±1.12)d、疾病用药治疗总时间(9.34±2.28)d明显短于对照组(5.32±0.95、7.35±0.99、8.84±1.16、11.35±2.63)d(P<0.05);支气管炎和肺炎疾病的治疗效果(总有效率90.9%)明显优于对照组(总有效率70.5%)(P<0.05);在支气管炎和肺炎疾病药物治疗期间不良反应例数(1例)明显少于对照组(8例)(P<0.05)。结论应用加味三拗汤对患有支气管炎和肺炎疾病的患儿实施治疗的临床效果非常明显。%Objective To study the application of modified three decoction implementation clinical effect of treatment for patients suffering from bronchitis and pneumonia in children with the disease. Methods 88 children with bronchitis and pneumonia disease in our hospital from September 2012 to September 2014 were randomly divided into control group and treatment group with 44 cases in each group. By using conventional western medicine treatment of the control group were treated; three Decoction to treat the treatment group in the implementation of control group medicine. Results The treatment group patients' body temperature returned to normal levels was (3.03±0.54)d, cough symptoms completely disappeared time was (5.10±0.62)d, respiratory function index return to normal time was (6.24±1.12)d, the total time the drug treatment of disease (9.34±2.28)d was significantly shorter than the control group (5.32±0.95, 7.35±0.99, 8.84±1.16, 11.35±2.63)d (P<0.05); treatment of

  14. Chronic hypersensitivity pneumonitis

    Directory of Open Access Journals (Sweden)

    Pereira CA

    2016-09-01

    Full Text Available Carlos AC Pereira,1 Andréa Gimenez,2 Lilian Kuranishi,2 Karin Storrer 2 1Interstitial Lung Diseases Program, 2Pulmonology Postgraduate, Federal University of São Paulo, São Paulo, Brazil Abstract: Hypersensitivity pneumonitis (HSP is a common interstitial lung disease resulting from inhalation of a large variety of antigens by susceptible individuals. The disease is best classified as acute and chronic. Chronic HSP can be fibrosing or not. Fibrotic HSP has a large differential diagnosis and has a worse prognosis. The most common etiologies for HSP are reviewed. Diagnostic criteria are proposed for both chronic forms based on exposure, lung auscultation, lung function tests, HRCT findings, bronchoalveolar lavage, and biopsies. Treatment options are limited, but lung transplantation results in greater survival in comparison to idiopathic pulmonary fibrosis. Randomized trials with new antifibrotic agents are necessary. Keywords: interstitial lung diseases, extrinsic allergic alveolitis, diffuse lung disease, lung immune response, HRCT, farmers lung

  15. Chronic pelvic floor dysfunction.

    Science.gov (United States)

    Hartmann, Dee; Sarton, Julie

    2014-10-01

    The successful treatment of women with vestibulodynia and its associated chronic pelvic floor dysfunctions requires interventions that address a broad field of possible pain contributors. Pelvic floor muscle hypertonicity was implicated in the mid-1990s as a trigger of major chronic vulvar pain. Painful bladder syndrome, irritable bowel syndrome, fibromyalgia, and temporomandibular jaw disorder are known common comorbidities that can cause a host of associated muscular, visceral, bony, and fascial dysfunctions. It appears that normalizing all of those disorders plays a pivotal role in reducing complaints of chronic vulvar pain and sexual dysfunction. Though the studies have yet to prove a specific protocol, physical therapists trained in pelvic dysfunction are reporting success with restoring tissue normalcy and reducing vulvar and sexual pain. A review of pelvic anatomy and common findings are presented along with suggested physical therapy management.

  16. Omalizumab for chronic urticaria

    DEFF Research Database (Denmark)

    Ivyanskiy, Ilya; Sand, Carsten; Thomsen, Simon Francis

    2012-01-01

    urticaria. We present a case series of 19 patients with chronic urticaria treated in a university department with omalizumab and give an overview of the existing literature comprising an additional 59 cases as well as a total of 139 patients enrolled in two randomized controlled trials comparing omalizumab...... with placebo. The collective evidence points to omalizumab as a safe and effective treatment option for patients with chronic urticaria who do not sufficiently respond to standard therapy as recommended by existing guidelines.......Omalizumab is a recombinant humanized monoclonal antibody that blocks the high-affinity Fc receptor of IgE. Omalizumab has been approved for the treatment of moderate to severe asthma; however, there is currently more and more data showing promising results in the management also of chronic...

  17. "复方板蓝根制剂"治疗鸡传染性支气管炎的效果%Effect of Compound Chinese Medicine——Banlangen on the Treatment of Avian Infectious Bronchitis of Chicken

    Institute of Scientific and Technical Information of China (English)

    刘芳; 宋云鹏

    2009-01-01

    [目的] 观察"复方板蓝根制剂"治疗自然感染鸡传染性支气管炎的效果.[方法] 采用0.33‰、0.67‰和1.33‰ 3种不同浓度的"复方板蓝根制剂"饲喂病鸡,对7 340只自然发病鸡进行治疗,观察该药的治疗效果.[结果] 根据流行病学调查、临床症状鉴别、病理剖检变化和实验室检查确诊2个鸡场的7 340只病鸡所患疾病为鸡传染性支气管炎.病鸡服用"复方板蓝根制剂"后病情很快得到控制,未经治疗的对照组自愈率为85.18%,症状恢复缓慢;3个"复方板蓝根制剂"组的治愈率均在97%以上,病死率显著低于对照组,且症状恢复较快;0.33‰"复方板蓝根制剂"组与病毒灵组疗效相当;0.67‰和1.33‰剂量治疗组治愈率显著高于0.33‰剂量组与病毒灵治疗组.[结论] "复方板蓝根制剂"可有效治疗自然感染发病的鸡传染性支气管炎,推荐剂量为0.67‰.%[Objective] The effect of the compound Chinese medicine--Banlangen on the prevention of chicken avian infectious bronchitis naturally infected was experimented. [Method] The ill chickens were fed with the Banlangen with 3 different concentrations of 0.33 ‰, 0.67 ‰ and 1.33 ‰. The efficiency on total of 7 340 chickens treated with the method was observed. [Results] 7 340 chickens in two chicken farms were confirmed to be infected by the avian infectious bronchitis disease according to the epidemiological investigation, the identification of clinical symptoms, the pathological change in autopsy and laboratory test. The disease of treated chickens was under control soon and the recovery rate of untreated chicken(CK) was 85.18%, which recovery speed was relevant slow. The recovery rate of 3 treatments was over 97% with fast recovery speed and significantly lower rate of dead chicken than the CK. The treatment of Banlangen with 0.33 ‰ was with same efficiency as the treatment of other chemical--Bingtuling. The efficiency of the treatment of Banlangen

  18. [Histaminergic angioedema and chronic urticaria].

    Science.gov (United States)

    Hacard, Florence; Nosbaum, Audrey; Bensaid, Benoit; Nicolas, Jean-François; Augey, Frédéric; Goujon, Catherine; Bérard, Frédéric

    2015-01-01

    Most angioedemas are histaminergic and correspond to deep urticarial swelling. Recurrent histaminergic angioedema led to the diagnosis of chronic urticaria, even when there are no superficial associated hives. Chronic urticaria is a benign disease, and autoimmune in 40 % of cases. The occurrence of angioedema in chronic urticaria is not a sign of severity. The occurrence of angioedema in chronic urticaria is associated with a longer duration of urticarial disease. NSAIDs and/or systemic corticotherapy are classic triggers of angioedema in chronic urticaria. In the absence of clinical endpoints, there is no need to make further assessment in chronic urticaria good responders to antihistamines.

  19. The clinical and economic burden of chronic obstructive pulmonary disease in the USA

    Directory of Open Access Journals (Sweden)

    Guarascio AJ

    2013-06-01

    Full Text Available Anthony J Guarascio,1 Shauntá M Ray,1 Christopher K Finch,2,3 Timothy H Self21University of Tennessee College of Pharmacy, Knoxville, 2University of Tennessee College of Pharmacy, Memphis, TN, USA; 3Methodist University Hospital, Memphis, TN, USAAbstract: Chronic obstructive pulmonary disease (COPD is the third most common cause of death in the USA. In 2010, the cost of COPD in the USA was projected to be approximately US$50 billion, which includes $20 billion in indirect costs and $30 billion in direct health care expenditures. These costs can be expected to continue to rise with this progressive disease. Costs increase with increasing severity of disease, and hospital stays account for the majority of these costs. Patients are diagnosed with COPD following a multifactorial assessment that includes spirometry, clinical presentation, symptomatology, and risk factors. Smoking cessation interventions are the most influential factor in COPD management. The primary goal of chronic COPD management is stabilization of chronic disease and prevention of acute exacerbations. Bronchodilators are the mainstay of COPD therapy. Patients with few symptoms and low exacerbation risk should be treated with a short-acting bronchodilator as needed for breathlessness. Progression of symptoms, as well as possible decline in forced expiratory volume in the first second of expiration (FEV1, warrant the use of long-acting bronchodilators. For patients with frequent exacerbations with or without consistent symptoms, inhaled corticosteroids should be considered in addition to a long-acting beta2-agonist (LABA or long-acting muscarinic antagonist (LAMA and may even consist of "triple therapy" with all three agents with more severe disease. Phosphodiesterase-4 inhibitors may be an option in patients with frequent exacerbations and symptoms of chronic bronchitis. In addition to a variety of novel ultra-LABAs, LAMAs and combination bronchodilator and inhaled corticosteroid

  20. Treating 32 Senile Patients with Asthmatic Bronchitis by Adjunctive Therapy of Infrared Cough Stickers%红外止咳贴辅助治疗老年患者喘息性支气管炎32例

    Institute of Scientific and Technical Information of China (English)

    戴玮

    2014-01-01

    Objective:To investigate clinical effects of infrared cough sticker in the treatment for senile pa-tients with asthmatic bronchitis. Methods:Sixty-four patients were randomized into the treatment group and the con-trol group, the control group were given with routine treatment of western medicine and the treatment group with in-frared cough sticker on the base of the treatment the control group received, both groups were treated for ten days and clinical effects of both groups were compared by the end of the treatment. Results:Total effective rate of the treatment group was 93.54%, higher than 90.63%of the control group, the difference had no statistical meaning be-tween both groups (P>0.05), the treatment group was shorter than the control group obviously in disappearing time of clinical symptom and hospitalization time (P<0.05). Conclusion:Infrared cough sticker is effective in the treat-ment for senile patients with asthmatic bronchitis.%目的:观察红外止咳贴辅助治疗老年患者喘息性支气管炎的临床疗效。方法:将64例患者随机分为治疗组和对照组各32例,对照组给予常规西医治疗,治疗组在对照组治疗的基础上加用红外止咳贴,2组均连续治疗10天,治疗结束后比较2组临床疗效。结果:总有效率治疗组为93.54%,对照组为90.63%,2组比较无统计学意义(P>0.05),临床症状消失时间和住院时间治疗组明显短于对照组(P<0.05)。结论:红外止咳贴辅助治疗老年喘息性支气管炎临床疗效显著。

  1. Lifetime environmental tobacco smoke exposure and the risk of chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Balmes John

    2005-05-01

    Full Text Available Abstract Background Exposure to environmental tobacco smoke (ETS, which contains potent respiratory irritants, may lead to chronic airway inflammation and obstruction. Although ETS exposure appears to cause asthma in children and adults, its role in causing COPD has received limited attention in epidemiologic studies. Methods Using data from a population-based sample of 2,113 U.S. adults aged 55 to 75 years, we examined the association between lifetime ETS exposure and the risk of developing COPD. Participants were recruited from all 48 contiguous U.S. states by random digit dialing. Lifetime ETS exposure was ascertained by structured telephone interview. We used a standard epidemiologic approach to define COPD based on a self-reported physician diagnosis of chronic bronchitis, emphysema, or COPD. Results Higher cumulative lifetime home and work exposure were associated with a greater risk of COPD. The highest quartile of lifetime home ETS exposure was associated with a greater risk of COPD, controlling for age, sex, race, personal smoking history, educational attainment, marital status, and occupational exposure to vapors, gas, dusts, or fumes during the longest held job (OR 1.55; 95% CI 1.09 to 2.21. The highest quartile of lifetime workplace ETS exposure was also related to a greater risk of COPD (OR 1.36; 95% CI 1.002 to 1.84. The population attributable fraction was 11% for the highest quartile of home ETS exposure and 7% for work exposure. Conclusion ETS exposure may be an important cause of COPD. Consequently, public policies aimed at preventing public smoking may reduce the burden of COPD-related death and disability, both by reducing direct smoking and ETS exposure.

  2. Chronic pancreatitis in dogs.

    Science.gov (United States)

    Watson, Penny

    2012-08-01

    Chronic pancreatitis used to be considered uncommon in dogs, but recent pathological and clinical studies have confirmed that it is in fact a common and clinically significant disease. Clinical signs can vary from low-grade recurrent gastrointestinal signs to acute exacerbations that are indistinguishable from classical acute pancreatitis. Chronic pancreatitis is a significant cause of chronic pain in dogs, which must not be underestimated. It also results in progressive impairment of endocrine and exocrine function and the eventual development of diabetes mellitus or exocrine pancreatic insufficiency or both in some affected dogs at end stage. The etiology is unknown in most cases. Chronic pancreatitis shows an increased prevalence in certain breeds, and recent work in English Cocker Spaniels suggests it is part of a polysystemic immune-mediated disease in this breed. The histological and clinical appearance is different in different breeds, suggesting that etiologies may also be different. Diagnosis is challenging because the sensitivities of the available noninvasive tests are relatively low. However, with an increased index of suspicion, clinicians will recognize more cases that will allow them to institute supportive treatment to improve the quality of life of the patient.

  3. Acetaminophen for Chronic Pain

    DEFF Research Database (Denmark)

    Ennis, Zandra Nymand; Dideriksen, Dorthe; Vaegter, Henrik Bjarke;

    2016-01-01

    strategies for acetaminophen use in chronic pain in both Embase and PubMed, 1,551 hits were obtained. Following cross-reference searches of both trials and 38 reviews, seven studies comparing acetaminophen in continuous dosing regimens of more than two weeks with placebo were included. The review...

  4. Refractory chronic migraine

    DEFF Research Database (Denmark)

    Martelletti, Paolo; Katsarava, Zaza; Lampl, Christian

    2014-01-01

    The debate on the clinical definition of refractory Chronic Migraine (rCM) is still far to be concluded. The importance to create a clinical framing of these rCM patients resides in the complete disability they show, in the high risk of serious adverse events from acute and preventative drugs...

  5. Diagnosing chronic rhinosinusitis

    DEFF Research Database (Denmark)

    Lange, B; Thilsing, T; Baelum, J;

    2013-01-01

    The European Position Paper on Rhinosinusitis and Nasal Polyps (EP3OS) incorporates symptomatic and endo- scopic criteria in the clinical diagnosis of chronic rhinosinusitis (CRS), while in epidemiological studies the definition is based on symptoms only. The aim of this study was to evaluate the...

  6. Chronic recurrent multifocal osteomyelitis

    NARCIS (Netherlands)

    Wedman, Jan; van Weissenbruch, Ranny

    2005-01-01

    We report what is, to our best knowledge, the first case of chronic recurrent multifocal osteomyelitis (CRMO) in which the frontal and sphenoid bones were involved. Characterized by a prolonged and fluctuating course of osteomyelitis at different sites, CRMO is self-limited, although sequelae can oc

  7. CHRONIC PROBLEM FAMILIES.

    Science.gov (United States)

    STONE, EDWARD

    THE REPORT POINTS OUT THAT, IN GENERAL, CHRONIC PROBLEM PARENTS GREW UP IN ENVIRONMENTS OF EMOTIONAL IMPOVERISHMENT, INCONSISTENCY, CONFUSION, AND DISORDER, OFTEN WITH DEPRIVATION OF FOOD, CLOTHING, AND SHELTER. THESE PARENTS CATEGORIZE PEOPLE AS THOSE WHO GIVE AND THOSE WHO TAKE. THEY BLAME THEIR PROBLEMS ON EXTERNAL CIRCUMSTANCES NOT UNDER THEIR…

  8. Chronic blood pressure control.

    Science.gov (United States)

    Brands, Michael W

    2012-10-01

    Chronic blood pressure is maintained within very narrow limits around an average value. However, the multitude of physiologic processes that participate in blood pressure control present a bewildering array of possibilities to explain how such tight control of arterial pressure is achieved. Guyton and Coleman and colleagues addressed this challenge by creating a mathematical model that integrated the short- and long-term control systems for overall regulation of the circulation. The hub is the renal-body fluid feedback control system, which links cardiac function and vascular resistance and capacitance with fluid volume homeostasis as the foundation for chronic blood pressure control. The cornerstone of that system is renal sodium excretory capability, which is defined by the direct effect of blood pressure on urinary sodium excretion, that is, "pressure natriuresis." Steady-state blood pressure is the pressure at which pressure natriuresis balances sodium intake over time; therefore, renal sodium excretory capability is the set point for chronic blood pressure. However, this often is misinterpreted as dismissing, or minimizing, the importance of nonrenal mechanisms in chronic blood pressure control. This article explains the renal basis for the blood pressure set point by focusing on the absolute dependence of our survival on the maintenance of sodium balance. Two principal threats to sodium balance are discussed: (1) a change in sodium intake or renal excretory capability and (2) a change in blood pressure. In both instances, circulatory homeostasis is maintained because the sodium balance blood pressure set point is reached.

  9. Chronic Kidney Disease

    Science.gov (United States)

    ... of the feet and ankles Causes & Risk FactorsWhat causes CKD?The most common causes of CKD are high blood pressure, diabetes and heart disease. ... caused by CKD.How else is CKD treated?Chronic kidney disease can cause other problems. Talk with your doctor about how ...

  10. EBV CHRONIC INFECTIONS

    Directory of Open Access Journals (Sweden)

    Eligio Pizzigallo

    2010-08-01

    Full Text Available The infection from Epstein-Barr virus (EBV or virus of infectious mononucleosis, together with other herpesviruses’ infections, represents a prototype of persistent viral infections characterized by the property of the latency. Although the reactivations of the latent infection are associated with the resumption of the viral replication and eventually with the “shedding”, it is still not clear if this virus can determine chronic infectious diseases, more or less evolutive. These diseases could include some pathological conditions actually defined as “idiopathic”and characterized by the “viral persistence” as the more credible pathogenetic factor. Among the so-called idiopathic syndromes, the “chronic fatigue syndrome” (CFS aroused a great interest around the eighties of the last century when, just for its relationship with EBV, it was called “chronic mononucleosis” or “chronic EBV infection”. Today CFS, as defined in 1994 by the CDC of Atlanta (USA, really represents a multifactorial syndrome characterized by a chronic course, where reactivation and remission phases alternate, and by a good prognosis. The etiopathogenetic role of EBV is demonstrated only in a well-examined subgroup of patients, while in most of the remaining cases this role should be played by other infectious agents - able to remain in a latent or persistent way in the host – or even by not infectious agents (toxic, neuroendocrine, methabolic, etc.. However, the pathogenetic substrate of the different etiologic forms seems to be the same, much probably represented by the oxidative damage due to the release of pro-inflammatory cytokines as a response to the triggering event (infectious or not infectious. Anyway, recently the scientists turned their’s attention to the genetic predisposition of the subjects affected by the syndrome, so that in the last years the genetic studies, together with those of molecular biology, received a great impulse

  11. Screening for Chronic Kidney Disease

    Science.gov (United States)

    Understanding Task Force Recommendations Screening for Chronic Kidney Disease The U.S. Preventive Services Task Force (Task Force) has issued a final recommendation on Screening for Chronic Kidney Disease (CKD) . This recommendation ...

  12. Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

    Science.gov (United States)

    ... and abnormal sensations. CIDP is closely related to Guillain-Barre syndrome and it is considered the chronic counterpart ... and abnormal sensations. CIDP is closely related to Guillain-Barre syndrome and it is considered the chronic counterpart ...

  13. Chronic Fatigue Syndrome (CFS): Symptoms

    Science.gov (United States)

    ... CDC.gov . Chronic Fatigue Syndrome (CFS) Share Compartir Symptoms On this Page Primary Symptoms Other Symptoms What's ... a doctor distinguish CFS from other illnesses. Primary Symptoms As the name chronic fatigue syndrome suggests , fatigue ...

  14. Defining and Measuring Chronic Conditions

    Centers for Disease Control (CDC) Podcasts

    2013-05-20

    This podcast is an interview with Dr. Anand Parekh, U.S. Department of Health and Human Services Deputy Assistant Secretary for Health, and Dr. Samuel Posner, Preventing Chronic Disease Editor in Chief, about the definition and burden of multiple chronic conditions in the United States.  Created: 5/20/2013 by Preventing Chronic Disease (PCD), National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 5/20/2013.

  15. Chronic diseases and life events accounted for 2-18 % population attributable risks for adult hearing loss: UK Adult Psychiatric Morbidity Survey, 2007.

    Science.gov (United States)

    Shiue, Ivy

    2016-01-01

    Links between chronic diseases and hearing loss in adults have emerged. However, previous investigations were not complete, and the role of life events was unclear. Therefore, it was aimed to examine the relationships of common chronic diseases and life events and adult hearing loss in a country-wide and population-based study. Data were retrieved from UK Adult Psychiatric Morbidity Survey, 2007, being cross-sectional, including demographics, self-reported prior health conditions and hearing loss (ever and in the last 12 months), and several major life events. Analyses included Chi square test, t test, logistic regression model, and population attributable risk estimation. People who had prior health conditions including cancer, migraine, dementia, depression, cataracts, chronic bronchitis, allergy, bowel problem, bladder problem, arthritis, muscle problem or skin problem tended to report hearing loss than their counterparts. People who have experienced major life events including post-traumatic stress disorder, serious illness of close relatives, death of family, serious problems with friends, major financial crisis, valuables stolen, being bullied, violence at home, sexual abuse or running away from home were also more likely to experience ever hearing loss problem or that in the last 12 months. 2.0-13.1 % adult hearing loss could be delayed or prevented by managing chronic diseases while 4.1-18.1 % might be delayed or prevented by minimizing the negative effects of life events. Chronic diseases and life events were associated with hearing loss in adults. Better managing lifestyle to minimize detrimental impacts in future health and nursing programs would be suggested.

  16. 内蒙中西部地区婴幼儿毛细支气管炎发病与血清IgA.C3浓度相关性探讨%ongolia Midwest infant capillary bronchitis disease and serum IgA.C3 concentration correlation is discussed

    Institute of Scientific and Technical Information of China (English)

    赵宇静

    2013-01-01

    Objective To explore the Inner Mongolia Midwest infant capillary bronchitis causes relates to the concentration of serum IgA ,C зchildren.Method For 1-2 years old children,134 cases of capillary bronchitis and at the same time on the hospital 1-2 years old and 100 cases children with bronchial pneumonia and.50 cases of normal control group,the application of turbidimetric method determination of peripheral blood serum IgA ,Cзconcentration,and comparative analysis.Results of capillary bronchitis group serum IgA,C зconcentration is the same with the normal group,no obvious changes,the feeling and bronchial pneumonia group of serum IgA, C зconcentration determination value compared to normal children changes.Conclusion in the same exposure,infection factors on sense and bronchial pneumonia group of serum IgA,C зconcentration change,capillary bronchitis group of serum IgA,C зconcentration change no difference,capillary bronchitis risk factors not sure,need to be researched.%目的:探讨内蒙中西部地区婴幼儿毛细支气管炎发病原因与患儿血清IgA、Cз浓度关系。方法对1-2岁毛细支气管炎患儿134例及同期入院1-2岁上感及支气管肺炎患儿100例,正常对照组50例,应用比浊法测定外周血血清 IgA、Cз浓度,并进行对比分析。结果毛细支气管炎组血清IgA、Cз浓度与正常组相同,无明显变化,上感及支气管肺炎组血清IgA、Cз浓度对比正常儿童测定值变化大。结论在相同感染因素暴露下,上感及支气管肺炎组血清IgA、Cз浓度改变,毛细支气管炎组血清IgA、Cз浓度变化无差异,提示毛细支气管炎患儿免疫功能异常,发病原因有待继续研究。

  17. Treating Chronic Myeloid Leukemia by Phase

    Science.gov (United States)

    ... Myeloid Leukemia (CML) Treating Chronic Myeloid Leukemia Treating Chronic Myeloid Leukemia by Phase Treatment options for people ... a stem cell donor with matching tissue type. Chronic phase The standard treatment for chronic phase CML ...

  18. [Polymorphic markers of the CYP1B1 (4326C > G), CYP2F1 (c.14_15insC), CYP2J2 (-76G > T), and CYP2S1 (13106C > T and 13255A > G) genes and genetic predisposition to chronic respiratory diseases induced by smoking and occupational factors].

    Science.gov (United States)

    Akhmadishina, L A; Korytina, G F; Victorova, T V

    2011-10-01

    The contribution of the polymorphic markers of cytochrome P450 genes to respiratory diseases caused by smoking and occupational factors has been assessed. For this purpose, PCR-RFLP analysis of the CYP1B1 (rs1056836, 4326C > G), CYP2F1 (rs11399890, c.14_15insC), CYP2J2 (rs890293, -76G > T), and CYP2S1 (rs34971233, 13106C > T and rs338583, 13255A > G) gene polymorphisms has been performed. The analysis has shown that the polymorphic variants of the CYP1B1 (rs1056836, 4326C > G) and CYP2F1 (rs11399890, c. 14_15insC) genes may contribute to the development of occupational chronic bronchitis. The proportion of CYP1B1* 1*3 heterozygotes in the group of patients with occupational chronic bronchitis is considerably greater than in the group of healthy workers (69.16% versus 53.29%; chi2 = 5.94, P = 0.02, P(cor) = 0.04, OR = 1.97, the 95% CI is 1.13-3.42). Patients with occupational chronic bronchitis and healthy workers significantly differed from each other in the frequency distribution of the genotypes ofthe CYP2F1 (rs11399890, c.14_15insC) polymorphic marker (chi2 = 6.18, d.f = 2, P = 0.05). The frequency of the wild type/ins heterozygous genotype for the CYP2F1 gene is higher in healthy workers (36.08%) than in patients (22.22%) (chi2 = 5.48, P = 0.02, P(cor) = 0.04, OR = 0.51, the 95% CI is 0.28-0.90). No association has been found between the CYP2J2 (rs890293, -76G > T) or CYP2S1 (rs34971233, 13106C > T, P466L and rs338583, 13255A > G) gene polymorphisms and respiratory diseases.

  19. Two novel neutralizing antigenic epitopes of the s1 subunit protein of a QX-like avian infectious bronchitis virus strain Sczy3 as revealed using a phage display peptide library.

    Science.gov (United States)

    Zou, Nianli; Xia, Jing; Wang, Fuyan; Duan, Zhenzhen; Miao, Dan; Yan, Qigui; Cao, Sanjie; Wen, Xintian; Liu, Ping; Huang, Yong

    2015-11-15

    The spike (S) protein of the infectious bronchitis virus (IBV) plays a central role in the pathogenicity, the immune antibody production, serotype and the tissue tropism. In this study, we generate 11 monoclonal antibodies (mAbs) against S1 subunit of IBV Sczy3 strain, and two mAbs 1D5 and 6A12 were positive in indirect ELISA against both His-S1 protein and the purified whole viral antigen. MAb 6A12 and 1D5 could recognized by other 10 IBV strains (IBVs) from five different genotypes, except that 1D5 had a relatively low reaction with two of the 10 tested IBVs. End-point neutralizing assay performed in chicken embro kidney (CEK) cells revealed that the neutralization titer of 6A12 and 1D5 against Sczy3 reached 1:44.7 and 1:40.6, respectively. After screening a phage display peptide library and peptide scanning, we identified two linear B-cell epitopes that were recognized by the mAbs 1D5 and 6A12, which corresponded to the amino acid sequences (87)PPQGMAW(93) and (412)IQTRTEP(418), respectively, in the IBV S1 subunit. Sequences comparison revealed that epitope (412)IQTRTEP(418) was conserved among IBVs, while the epitope (87)PPQGMAW(93) was relatively variable among IBVs. The novel mAbs and the epitopes identified will be useful for developing diagnostic assays for IBV infections.

  20. Role of a proprietary propolis-based product on the wait-and-see approach in acute otitis media and in preventing evolution to tracheitis, bronchitis, or rhinosinusitis from nonstreptococcal pharyngitis

    Science.gov (United States)

    Di Pierro, Francesco; Zanvit, Alberto; Colombo, Maria

    2016-01-01

    Antipyretics and/or anti-inflammatory drugs along with a wait-and-see approach are the only treatments recommended in early acute otitis media (AOM) or viral pharyngitis. Propolis has been widely investigated for its antibacterial, antiviral, and anti-inflammatory properties and could perhaps be administered as an add-on therapy during watchful waiting in AOM or for better control of symptoms in nonstreptococcal pharyngitis. However, propolis has well-known problems of poor solubility and low oral bioavailability. We therefore analyzed a proprietary propolis-based product (Propolisina®) developed to overcome these limitations, in a retrospective, open-label, controlled study of Streptococcus pyogenes-negative children with a diagnosis of AOM or pharyngitis. Our results show that the use of propolis supplement for 72 hours lessens the severity of AOM and viral pharyngitis, reduces the use of antipyretics and anti-inflammatory drugs, and decreases the rate of evolution to tracheitis, bronchitis, and rhinosinusitis. Our study shows that propolis could be used as a safe add-on therapy in case of AOM and/or viral pharyngitis. PMID:27956842

  1. Role of a proprietary propolis-based product on the wait-and-see approach in acute otitis media and in preventing evolution to tracheitis, bronchitis, or rhinosinusitis from nonstreptococcal pharyngitis.

    Science.gov (United States)

    Di Pierro, Francesco; Zanvit, Alberto; Colombo, Maria

    2016-01-01

    Antipyretics and/or anti-inflammatory drugs along with a wait-and-see approach are the only treatments recommended in early acute otitis media (AOM) or viral pharyngitis. Propolis has been widely investigated for its antibacterial, antiviral, and anti-inflammatory properties and could perhaps be administered as an add-on therapy during watchful waiting in AOM or for better control of symptoms in nonstreptococcal pharyngitis. However, propolis has well-known problems of poor solubility and low oral bioavailability. We therefore analyzed a proprietary propolis-based product (Propolisina(®)) developed to overcome these limitations, in a retrospective, open-label, controlled study of Streptococcus pyogenes-negative children with a diagnosis of AOM or pharyngitis. Our results show that the use of propolis supplement for 72 hours lessens the severity of AOM and viral pharyngitis, reduces the use of antipyretics and anti-inflammatory drugs, and decreases the rate of evolution to tracheitis, bronchitis, and rhinosinusitis. Our study shows that propolis could be used as a safe add-on therapy in case of AOM and/or viral pharyngitis.

  2. Role of a proprietary propolis-based product on the wait-and-see approach in acute otitis media and in preventing evolution to tracheitis, bronchitis, or rhinosinusitis from nonstreptococcal pharyngitis

    Directory of Open Access Journals (Sweden)

    Di Pierro F

    2016-11-01

    Full Text Available Francesco Di Pierro,1 Alberto Zanvit,2 Maria Colombo3 1Scientific Department, Velleja Research, 2Biological Dentistry Department, Italian Stomatology Institute, 3ATS, District 5, Milan, Italy Abstract: Antipyretics and/or anti-inflammatory drugs along with a wait-and-see approach are the only treatments recommended in early acute otitis media (AOM or viral pharyngitis. Propolis has been widely investigated for its antibacterial, antiviral, and anti-inflammatory properties and could perhaps be administered as an add-on therapy during watchful waiting in AOM or for better control of symptoms in nonstreptococcal pharyngitis. However, propolis has well-known problems of poor solubility and low oral bioavailability. We therefore analyzed a proprietary propolis-based product (Propolisina® developed to overcome these limitations, in a retrospective, open-label, controlled study of Streptococcus pyogenes-negative children with a diagnosis of AOM or pharyngitis. Our results show that the use of propolis supplement for 72 hours lessens the severity of AOM and viral pharyngitis, reduces the use of antipyretics and anti-inflammatory drugs, and decreases the rate of evolution to tracheitis, bronchitis, and rhinosinusitis. Our study shows that propolis could be used as a safe add-on therapy in case of AOM and/or viral pharyngitis. Keywords: pediatric infections, cogrinding, bioavailability, propolis

  3. 对1例急性喘息性支气管炎患者进行全程化药学监护的体会%The experience of full pharmaceutical care in one patient with acute asthmatic bronchitis

    Institute of Scientific and Technical Information of China (English)

    石俊峰; 徐利; 韩旭亮; 龙丽辉

    2012-01-01

    In this article, one case of individualized pharmaceutical care for one hospitalized patient with acute asthmatic bronchitis was reported to explore the role of clinical pharmacists in patient treatment. In the course of treatment, the treatment protocol optimization was carried out by a team composed of clinical pharmacists, clinicians and nurse. To protect the patient's medication safety and effectiveness, they worked together to accomplish proper operation of drug infusion, medication education to patients and adverse reaction monitoring.%本文通过对我院1例急性喘息性支气管炎患者的个体化药学监护,探讨临床药师在患者治疗过程中的作用.在治疗过程中,临床药师与临床医师、护师组成治疗团队,共同完成治疗方案的优化、输注药物的正确操作、对患者的用药教育以及不良反应监测,保障了患者的用药安全、有效.

  4. Diagnosis, Prevention and Treatment of Glandular Stomachk Type Infectious Bronchitis Complicated with Colibacillosis%鸡腺胃型传染性支气管炎继发大肠杆菌病的诊断与防治

    Institute of Scientific and Technical Information of China (English)

    汪德生; 王文亮; 彭晓军

    2011-01-01

    某养殖场饲养的麻黄鸡(882)发生以拉黄绿色稀粪、咳嗽、伸颈张口呼吸、腺胃显著肿大等为特征的病例。通过对送检病死鸡详细解剖病变观察和实验室诊断,结果表明,造成本次疫病发生的主要原因是腺胃型传染性支气管炎病毒感染继发大肠杆菌病。%A group of Mahuang chickens(g82) from a brooding farm appeared the symptoms of yellow- green dilute manure, cough, dyspnea and proventricular significant enlargement. Finally, the chicken were diagnosised as avian proventricular type infectious bronchitis and escherichia coli secondary infection by pathological anatomy and a series of laboratory diagnosis.

  5. 重症新型甲型H1N1流感患儿合并塑型性支气管炎一例并文献复习%Plastic bronchitis associated with severe influenza A (H1N1) in children: a case report and review of the literature

    Institute of Scientific and Technical Information of China (English)

    孙德军; 杨友生; 王宝春

    2010-01-01

    Objective To improve understanding of the pathological and clinical features,diagnosis and treatment of plastic bronchitis associate with influenza A ( H1N1 ).Methods One case of plastic bronchitis associated with influenza A ( H1N1 ) diagnosed and treated in our hospital in January 2010 was reported and 19 cases of plastic bronchitis reported in the literature were reviewed.Results We describe a 5-year-old Chinese Japanese boy presenting with cough for 2 days,gasping and fever for 1 day was admitted.Left lung atelectasis and pneumothorax were found on chest X-ray examination.Pathologically,plastic bronchitis was diagnosed after the endogenous foreign body was extracted by bronchoscopy and classified as type 1 cast.In addition,influenza A (H1N1) was confirmed by the swabs which showed positive for H1N1 nucleic acid.The condition was controlled and the patient was cured and discharged after 16-days' treatment with antiviral therapy,low-dose corticosteroids,and antibiotics.Conclusion Plastic bronchitis associated with influenza A (H1N1) is a rare life-threatening disorder.The diagnosis could be made based on pathological findings of the bronchial casts as well as the positive H1N1 nucleic acid detection.Bronchoscopic extraction of casts in plastic bronchitis is not only useful for early diagnosis but an effective therapeutic modality for the disease.Influenza A( H1N1 ) may be a cause of plastic bronchitis.%目的 提高对新型甲型H1N1流感(简称甲型流感)合并塑型性支气管炎病理特点、临床特征、诊断、治疗的认识.方法 报道2010年1月厦门大学附属中山医院中心ICU收治的1例甲型流感合并塑型性支气管炎病例并进行相关文献复习.结果 患儿男,5岁,日籍华裔,咳嗽2 d加剧伴气喘,发热1 d,X线胸片示左肺不张、气胸,支气管镜检查吸出条索状异物,病理结果显示为塑型性支气管炎Ⅰ型,咽拭子甲型流感核酸检测阳性,经抗病毒、小量糖皮质激素、

  6. Mortality rates for chronic lower respiratory diseases in Italy from 1979 to 2010: an age–period–cohort analysis

    Directory of Open Access Journals (Sweden)

    Giancarlo Pesce

    2016-03-01

    Full Text Available Chronic lower respiratory diseases (CLRDs are a major cause of morbidity and mortality worldwide. The objectives of this study were to estimate the trends in CLRD mortality in Italy, and the specific contributions of age, time period and birth cohort in driving these trends. Population and cause-of-death data in Italy between 1979 and 2010 were collected from the World Health Organization website. Age-specific mortality rates for CLRDs, and effects for age, time period and birth cohort on mortality trends were estimated using age–period–cohort models. Chronic obstructive pulmonary disease (COPD and chronic bronchitis represent nearly 98% of the deaths from CLRDs. Despite the overall number of deaths have been stable (in men or increasing (in women, the age-standardised rates have been steadily decreasing from 1979 to 2010, passing from 104.3 to 55.4 per 100 000 person-years in men and from 32.2 to 19.6 per 100 000 person-years in women. The average relative annual decrease was −3.6% in men and −2.7% in women. Since the end of the 1990s, the decreasing trend of CLRD mortality has started to level off, in particular in women. The decrease in CLRD mortality rates has been more accentuated in more recent cohorts and in younger age groups. Both birth cohort and time period significantly affected the CLRD mortality rates, suggesting that changes in the spread of risk factors (smoking habits, early-life and occupational exposures across different birth cohorts, as well as in advanced in healthcare and medical practice, may have played a major role in secular changes in COPD mortality rates in Italy.

  7. Volumetric capnography for the evaluation of chronic airways diseases

    Directory of Open Access Journals (Sweden)

    Veronez L

    2014-09-01

    Full Text Available Liliani de Fátima Veronez,1 Monica Corso Pereira,2 Silvia Maria Doria da Silva,2 Luisa Affi Barcaui,2 Eduardo Mello De Capitani,2 Marcos Mello Moreira,2 Ilma Aparecida Paschoalz2 1Department of Physical Therapy, University of Votuporanga (Educational Foundation of Votuporanga, Votuporanga, 2Department of Internal Medicine, School of Medical Sciences, State University of Campinas (UNICAMP, Campinas, Sao Paulo, BrazilBackground: Obstructive lung diseases of different etiologies present with progressive peripheral airway involvement. The peripheral airways, known as the silent lung zone, are not adequately evaluated with conventional function tests. The principle of gas washout has been used to detect pulmonary ventilation inhomogeneity and to estimate the location of the underlying disease process. Volumetric capnography (VC analyzes the pattern of CO2 elimination as a function of expired volume.Objective: To measure normalized phase 3 slopes with VC in patients with non-cystic fibrosis bronchiectasis (NCB and in bronchitic patients with chronic obstructive pulmonary disease (COPD in order to compare the slopes obtained for the groups.Methods: NCB and severe COPD were enrolled sequentially from an outpatient clinic (Hospital of the State University of Campinas. A control group was established for the NCB group, paired by sex and age. All subjects performed spirometry, VC, and the 6-Minute Walk Test (6MWT. Two comparisons were made: NCB group versus its control group, and NCB group versus COPD group. The project was approved by the ethical committee of the institution. Statistical tests used were Wilcoxon or Student’s t-test; P<0.05 was considered to be a statistically significant difference.Results: Concerning the NCB group (N=20 versus the control group (N=20, significant differences were found in body mass index and in several functional variables (spirometric, VC, 6MWT with worse results observed in the NCB group. In the comparison between

  8. [Chronic inflammatory demyelinating polyradiculoneuropathy].

    Science.gov (United States)

    Franques, J; Azulay, J-P; Pouget, J; Attarian, S

    2010-06-01

    Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a demyelinating chronic neuropathy of immune origin whose diagnosis is based upon clinical, biological and electrophysiological data; previously critical to the diagnosis the nerve biopsy is now restricted to the rare situations where accurate diagnosis cannot be reached using these data alone. CIDP are mainly idiopathic, but a few associated diseases must be sought for as they require specific attention. Such associated diseases must particularly be discussed when the manifestations are severe or resistant to immunomodulating or immunosuppressive agents. Indeed, idiopathic CIDP are usually responsive to these treatments. The effectiveness of these treatments is limited by the importance of the secondary axonal loss. The dependence or the resistance may sometimes justify the association of several immunomodulating treatments. A single randomized controlled trial support the use of cytotoxic drugs and none with rituximab.

  9. Chronic intestinal pseudoobstruction syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Yeon, Kyung Mo; Seo, Jeong Kee; Lee, Yong Seok [Seoul National University Children' s Hospital, Seoul (Korea, Republic of)

    1992-03-15

    Chronic intestinal pseudoobstruction syndrome is a rare clinical condition in which impaired intestinal peristalsis causes recurrent symptoms of bowel obstruction in the absence of a mechanical occlusion. This syndrome may involve variable segments of small or large bowel, and may be associated with urinary bladder retention. This study included 6 children(3 boys and 3 girls) of chronic intestinal obstruction. Four were symptomatic at birth and two were of the ages of one month and one year. All had abdominal distension and deflection difficulty. Five had urinary bladder distension. Despite parenteral nutrition and surgical intervention(ileostomy or colostomy), bowel obstruction persisted and four patients expired from sepses within one year. All had gaseous distension of small and large bowel on abdominal films. In small bowel series, consistent findings were variable degree of dilatation, decreased peristalsis(prolonged transit time) and microcolon or microrectum. This disease entity must be differentiated from congenital megacolon, ileal atresia and megacystis syndrome.

  10. Bilateral chronic subdural hematoma

    DEFF Research Database (Denmark)

    Andersen-Ranberg, Nina Christine; Poulsen, Frantz Rom; Bergholt, Bo

    2017-01-01

    OBJECTIVE Bilateral chronic subdural hematoma (bCSDH) is a common neurosurgical condition frequently associated with the need for retreatment. The reason for the high rate of retreatment has not been thoroughly investigated. Thus, the authors focused on determining which independent predictors...... are associated with the retreatment of bCSDH with a focus on surgical laterality. METHODS In a national database of CSDHs (Danish Chronic Subdural Hematoma Study) the authors retrospectively identified all bCSDHs treated in the 4 Danish neurosurgical departments over the 3-year period from 2010 to 2012....... Univariate and multivariate analyses were performed to determine the relationship between retreatment of bCSDH and clinical, radiological, and surgical variables. RESULTS Two hundred ninety-one patients with bCSDH were identified, and 264 of them underwent unilateral (136 patients) or bilateral (128 patients...

  11. Chronic pneumonitis of infancy

    Energy Technology Data Exchange (ETDEWEB)

    Abe, Katsumi; Kamata, Noriko; Okazaki, Eiwa [Department of Radiology, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8677 (Japan); Moriyama, Sachiko; Funata, Nobuaki [Department of Pathology, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8677 (Japan); Takita, Junko; Yamada, Hideo; Takayama, Naohide [Department of Pediatrics, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8677 (Japan)

    2002-07-01

    Chronic pneumonitis of infancy (CPI) is a very rare lung disease in infants and young children. We report a 33-day-old infant with CPI, focusing on the radiologic aspects of the disease. Chest radiographs showed variable and non-specific appearances including ground-glass shadowing, consolidation, volume loss, and hyperinflation. Dense alveolar opacities progressed as CPI advanced. The radiologic features of our case reflected pathologic changes. (orig.)

  12. Renal failure (chronic)

    OpenAIRE

    Clase, Catherine

    2011-01-01

    Chronic renal failure is characterised by a gradual and sustained decline in renal clearance or glomerular filtration rate (GFR). Continued progression of renal failure will lead to renal function too low to sustain healthy life. In developed countries, such people will be offered renal replacement therapy in the form of dialysis or renal transplantation. Requirement for dialysis or transplantation is termed end-stage renal disease (ESRD).Diabetes, glomerulonephritis, hypertension, pyelone...

  13. Chronic Stress and Performance

    Science.gov (United States)

    2011-09-01

    to the cannabinoid CB(1) receptor agonist HU-210 following chronic stress. European Journal of Pharmacology, 499(3), 291-295. Holscher, C. (1999...learning and memory, has the highest concentration of GC receptors in the brain and is involved in the stress response. Extensive research has... receptor levels than stressed male rodents (Konkle, 2003; Figueiredo, 2002; Handa, 1994). Males and females react to stress differently, so two models

  14. EBV CHRONIC INFECTIONS

    Directory of Open Access Journals (Sweden)

    Delia Racciatti

    2010-02-01

    Full Text Available

    The infection from Epstein-Barr virus (EBV or virus of infectious mononucleosis, together with other herpesviruses’ infections, represents a prototype of persistent viral infections characterized by the property of the latency. Although the reactivations of the latent infection are associated with the resumption of the viral replication and eventually with the “shedding”, it is still not clear if this virus can determine chronic infectious diseases, more or less evolutive. These diseases could include some pathological conditions actually defined as “idiopathic”and characterized by the “viral persistence” as the more credible pathogenetic factor. Among the so-called idiopathic syndromes, the “chronic fatigue syndrome” (CFS aroused a great interest around the eighties of the last century when, just for its relationship with EBV, it was called “chronic mononucleosis” or “chronic EBV infection”.

    Today CFS, as defined in 1994 by the CDC of Atlanta (USA, really represents a multifactorial syndrome characterized by a chronic course, where reactivation and remission phases alternate, and by a good prognosis

  15. Chronic arsenic poisoning.

    Science.gov (United States)

    Hall, Alan H

    2002-03-10

    Symptomatic arsenic poisoning is not often seen in occupational exposure settings. Attempted homicide and deliberate long-term poisoning have resulted in chronic toxicity. Skin pigmentation changes, palmar and plantar hyperkeratoses, gastrointestinal symptoms, anemia, and liver disease are common. Noncirrhotic portal hypertension with bleeding esophageal varices, splenomegaly, and hypersplenism may occur. A metallic taste, gastrointestinal disturbances, and Mee's lines may be seen. Bone marrow depression is common. 'Blackfoot disease' has been associated with arsenic-contaminated drinking water in Taiwan; Raynaud's phenomenon and acrocyanosis also may occur. Large numbers of persons in areas of India, Pakistan, and several other countries have been chronically poisoned from naturally occurring arsenic in ground water. Toxic delirium and encephalopathy can be present. CCA-treated wood (chromated copper arsenate) is not a health risk unless burned in fireplaces or woodstoves. Peripheral neuropathy may also occur. Workplace exposure or chronic ingestion of arsenic-contaminated water or arsenical medications is associated with development of skin, lung, and other cancers. Treatment may incklude the use of chelating agents such as dimercaprol (BAL), dimercaptosuccinic acid (DMSA), and dimercaptopanesulfonic acid (DMPS).

  16. Stuffy Nose

    Science.gov (United States)

    ... the lower airways, leading to a chronic cough, bronchitis, or asthma. Acute sinus infections generally respond to antibiotic treatment; chronic sinusitis may require surgery. Structural abnormalities These ...

  17. Chronic effects of air pollution on respiratory health in Southern California children: findings from the Southern California Children's Health Study.

    Science.gov (United States)

    Chen, Zhanghua; Salam, Muhammad T; Eckel, Sandrah P; Breton, Carrie V; Gilliland, Frank D

    2015-01-01

    Outdoor air pollution is one of the leading contributors to adverse respiratory health outcomes in urban areas around the world. Children are highly sensitive to the adverse effects of air pollution due to their rapidly growing lungs, incomplete immune and metabolic functions, patterns of ventilation and high levels of outdoor activity. The Children's Health Study (CHS) is a continuing series of longitudinal studies that first began in 1993 and has focused on demonstrating the chronic impacts of air pollution on respiratory illnesses from early childhood through adolescence. A large body of evidence from the CHS has documented that exposures to both regional ambient air and traffic-related pollutants are associated with increased asthma prevalence, new-onset asthma, risk of bronchitis and wheezing, deficits of lung function growth, and airway inflammation. These associations may be modulated by key genes involved in oxidative-nitrosative stress pathways via gene-environment interactions. Despite successful efforts to reduce pollution over the past 40 years, air pollution at the current levels still brings many challenges to public health. To further ameliorate adverse health effects attributable to air pollution, many more toxic pollutants may require regulation and control of motor vehicle emissions and other combustion sources may need to be strengthened. Individual interventions based on personal susceptibility may be needed to protect children's health while control measures are being implemented.

  18. Chronic Prostatitis/Chronic Pelvic Pain Syndrome Diagnosis and Treatment

    Directory of Open Access Journals (Sweden)

    Cem Nedim Yuceturk

    2014-08-01

    Full Text Available Chronic prostatitis is a chronic syndrome that effects men with a wide range of age. The etiology, natural history and appropriate therapy models are still unclear. According to the classification of National Institutes of Health; 4 types of prostatitis were defined; acute bacterial prostatitis (category I, chronic bacterial prostatitis (category II, chronic nonbacterial prostatitis/chronic pelvic pain syndrome (category III and asymptomatic prostatitis (category IV.Since microorganisms can only be isolated from a small percent of patients, empiric treatment is given to the most of the men. Multidisciplinary approach to the patients with suspected chronic prostatitis will help clinicians to play an active role in the treatment and prevent unnecessary medical therapies. [Archives Medical Review Journal 2014; 23(4.000: 691-702

  19. Chronic radiation syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Akleyev, Alexander V. [Urals Research Centre for Radiation Medicine, Chelyabinsk (Russian Federation). Clinical Dept.

    2014-04-01

    Comprehensive analysis of chronic radiation syndrome, covering epidemiology, pathogenesis, pathoanatomy, diagnosis and treatment. Based on observations in a unique sample of exposed residents of the Techa riverside villages in the Urals. Casts new light on the condition. Of value for all practitioners and researchers with an interest in chronic radiation syndrome. This book covers all aspects of chronic radiation syndrome (CRS) based on observations in a unique sample of residents of the Techa riverside villages in the southern Urals who were exposed to radioactive contamination in the 1950s owing to releases of liquid radioactive wastes from Mayak Production Association, which produced plutonium for weapons. In total, 940 cases of CRS were diagnosed in this population and these patients were subjected to detailed analysis. The opening chapters address the definition and classification of CRS, epidemiology and pathogenesis, covering molecular and cellular mechanisms, radioadaptation, and the role of tissue reactions. The pathoanatomy of CRS during the development and recovery stages is discussed for all organ systems. Clinical manifestations of CRS at the different stages are then described in detail and the dynamics of hematopoietic changes are thoroughly examined. In the following chapters, principles of diagnosis (including assessment of the exposure doses to critical organs) and differential diagnosis from a wide range of other conditions are discussed and current and potential treatment options, described. The medical and social rehabilitation of persons with CRS is also covered. This book, which casts new light on the condition, will be of value for all practitioners and researchers with an interest in CRS.

  20. Chronic cough in children.

    Science.gov (United States)

    Acosta, Rigoberto; Bahna, Sami L

    2014-08-01

    Cough is probably the most common cause of seeking medical care in pediatric practice. Most acute cough is caused by infection and usually resolves within less than 4 weeks. If it lasts longer, it is considered chronic and deserves investigation to identify the underlying cause, which can be almost any of a wide variety of illnesses of the respiratory tract and certain extrathoracic conditions. This review provides an optimal approach for diagnosis through a skillful history taking, physical examination, and selection of appropriate tests.

  1. The Chronic Poverty Report 2005

    OpenAIRE

    The Chronic Poverty Research Centre, CPRC

    2005-01-01

    The report examines what chronic poverty is and why it matters, who the chronically poor are, where they live, what causes poverty to be persistent and what should be done about it. It argues that approaches to development policy must acknowledge the agency of the chronically poor themselves in overcoming their poverty. But they also need real commitment, matched by actions and resources, to support their efforts to attain their rights and overcome the obstacles that trap them in poverty.

  2. Treatment Strategies for Chronic Cases

    Directory of Open Access Journals (Sweden)

    Susan M Lord

    2003-01-01

    Full Text Available The treatment of chronic somatic pain, including pain referred to the head, neck, shoulder girdle and upper limb from somatic structures, is addressed. Levels of evidence for the various treatments that have been prescribed for chronic whiplash associated disorders are considered. The challenge to find a treatment strategy for chronic pain after whiplash that completely relieves the condition and prevents its sequelae is reviewed.

  3. Late and chronic Lyme disease.

    Science.gov (United States)

    Donta, Sam T

    2002-03-01

    This article reviews the late and chronic manifestations of Lyme disease. Special attention is given to the chronic manifestations of the disease, detailing its pathogenesis, clinical spectrum, and laboratory criteria for the diagnosis. Based on experimental evidence and experience, approaches to the successful treatment of the late and chronic disease are outlined. Much additional work is needed to improve the understanding of the underlying pathophysiology of the disease, its diagnosis and treatment.

  4. Chronic avulsive injuries of childhood

    Energy Technology Data Exchange (ETDEWEB)

    Donnelly, L.F.; Helms, C.A. [Dept. of Radiology, Duke Univ. Medical Center, Durham, NC (United States); Bisset, G.S. III [Dept. of Radiology, Duke Univ. Medical Center, Durham, NC (United States)]|[Department of Pediatrics, Duke University Medical Center, Durham, NC (United States); Squire, D.L. [Department of Pediatrics, Duke University Medical Center, Durham, NC (United States)

    1999-03-01

    Children and adolescents are prone to avulsive injuries related to a combination of their propensity for great strength, ability to sustain extreme levels of activity, and immature growing apophyses. Appropriate interpretation of imaging studies showing chronic avulsive injuries is essential so that the irregularity and periostitis that can be associated with chronic avulsions is not misinterpreted as probable malignancy. This article reviews the chronic avulsive injuries of childhood. (orig.) With 12 figs., 8 refs.

  5. Primary diagnosis and therapy tests of nephropathogenic avian infectious bronchitis%鸡肾型传染性支气管炎的初步诊断与治疗

    Institute of Scientific and Technical Information of China (English)

    李瑞明; 史玉静; 韩涛; 韩忠燕; 宋小白

    2011-01-01

    [Objective ]The present study was conducted to investigate the epidemiology of avian infectious bronchitis (IB) in Qinhuangdao city of Hebei province, and to isolate the local representative strain of IB virus for development of immuo-vaccine. [Method]The epidemiology investigation, clinical manifestations and pathological changes in IB were recorded. The liver and kidney suspension of freshly sampled chicken were inoculated to ten--day SPF chick embryo allantoic cavity and the chicken embryo allantois solution was collected to conduct agar diffuse, haemagglutination (HA) and animal test. The comprehensive therapy was also practiced. [ Result ]The kidney of inoculated chick showed swelling and was found pale colored. White urate deposition in ureter was observed. The agar diffuse test result of allantois liquid showed positive results, as well as the HA and animal test results revealed that the isolated strain was IB virus. Based on pathological diagnosis, the lB was identified as nephropathgenic lB. The inactivated vaccine was made with isolated strains of nephropathogenic infectious bronchitis viruses. After 5 days of treatment with Hukang, Shenzhishuang, Hushentong and other medicines, the mortality of diseased chicken was recorded from 0.4 to 1.0%, the symptom in respiratory tract of chicken population decreased and the eggs production increased. The curative rate of lB in chicken reached 92.4%. [Conclustion ]The results of present study confirmed the disease as nephropathgenic lB. The proper medication and and immunization according to the virus strain can prevent the disease.%[目的]研究河北秦皇岛地区的鸡肾型鸡传染性支气管炎(IB)流行病学、分离鉴定地方代表毒株,为有效防制当地鸡肾型IB及研制具有免疫针对性的疫苗制剂提供参考依据.[方法]通过流行病学调查、临床症状、病理变化观察,取新鲜病死雏鸡肝脏、肾脏组织悬浮液接种10日龄SPF鸡胚尿囊腔,收集鸡胚尿

  6. A STUDY TO EVALUATE THE ROLE OF ELECTROCARDIOGRAPHIC CHANGES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

    Directory of Open Access Journals (Sweden)

    Jagadeesh

    2015-02-01

    were males. For diagnosis of COPD, guidelines by American Thoracic Society 1 and also by British Thoracic Society 2 were followed. COPD included chronic bronchitis and emphysema cases, but asthma was excluded, as airflow obstruction is largely reversible in this condition. Some other ch ronic lung diseases were also excluded. To assess diagnostic values of ECG, a control group of patients who attended OPD for respiratory problems other than COPD was also considered. Other respiratory diseases like pulmonary tuberculosis, non - tubercular pu lmonary infections, pleural disease, malignancy etc ., were diagnosed by adopting their respective diagnostic criteria available along with clinical judgment . Information of socio - demographic characteristics like age, sex, religion, socioeconomic status (SE S, social background, occupation and smoking habits was collected. Study subjects were classified according to spectrum of respiratory diseases. Patients underwent different clinical and radiological investigations. Further evaluation was also done by ECG . A 12 lead ECG including 3 bipolar limb leads, 3 unipolar limb leads and 6 unipolar precordial leads was performed. All necessary precautions desired in ECG were observed. ECG was done by single channel BPL card art various108T/MK - V I machine. Various ECG parameters like rate, axis deviation, P - wave changes, QRS complex, T - wave, ST changes etc. were observed. The axis of P - value and QRS complex was calculated by hex axial reference system. The study was approved by Institutional research committee and all ethical guidelines of Helsinki 3 were followed. RESULTS AND CONCLUSION: A total 100 patient of COPD were studied, out of which there were 30 females and 70 males. Respirat ory problems were more common among rural males of low socio - economic group. COPD particularly chronic bronchitis was the commonest respiratory problem next to pulmonary tuberculosis. In spite of normal heart rate observed in 71.4% COPD patients

  7. Understanding Biofilms in Chronic Sinusitis.

    Science.gov (United States)

    Tajudeen, Bobby A; Schwartz, Joseph S; Palmer, James N

    2016-02-01

    Chronic sinusitis is a burdensome disease that has substantial individual and societal impact. Although great advances in medical and surgical therapies have been made, some patients continue to have recalcitrant infections. Microbial biofilms have been implicated as a cause of recalcitrant chronic sinusitis, and recent studies have tried to better understand the pathogenesis of chronic sinusitis as it relates to microbial biofilms. Here, we provide an overview of biofilms in chronic sinusitis with emphasis on pathogenesis, treatment, and future directions. In addition, recent evidence is presented, elucidating the role of bitter taste receptors as a possible key factor leading to biofilm formation.

  8. Diagnostic dilemmas in chronic urticaria.

    Science.gov (United States)

    Toubi, E; Grattan, C; Zuberbier, T

    2015-06-01

    The European Academy of Allergy and Clinical Immunology (EAACI)/Global Allergy and Asthma European Network (GA(2) LEN)/European Dermatology Forum (EDF)/World Allergy Organization (WAO) recently published updated recommendations for the classification, diagnosis and management of chronic urticaria (CU). This article discusses several cases of CU that provide examples of how the recommendations in the guidelines can be implemented in the diagnosis of chronic spontaneous urticaria (CSU) (also called chronic idiopathic urticaria [CIU]), chronic inducible urticaria (CINDU) or CU with comorbidities.

  9. A comparative study of the clinical efficacy of ambroxol hydrochloride combined with hydrocortisone sodium succinate in the treatment of infantile bronchitis%盐酸氨溴索与氢化可的松琥珀酸钠治疗毛细支气管炎的临床疗效对比研究

    Institute of Scientific and Technical Information of China (English)

    许焕胜

    2016-01-01

    Objective To investigate the ambroxol hydrochloride combined with hydrocortisone sodium succinate in treatment of children with bronchiolitis.Methods 120 children with bronchitis in our hospital from January 2014 to September 2015 were selected, divided into a control group and an observation group according to the random number table method. The two groups were treated with conventional bronchitis treatment and nursing, the control group was treated with hydrocortisone sodium succinate treatment, the observation group with ambroxol hydrochloride in the treatment of choice. After treatment, the clinical effect and the clinical symptoms and time of bronchitis symptoms disappeared between two groups were compared.Results Patients in the observation group after the atomization inhalation of ambroxol hydrochloride, the clinical effective rate was 75%, which was significantly higher than that in the control group, the bronchitis curative effect rate was 40%, the difference was statistically significant (P<0.05). Observation group in children with bronchiolitis related clinical symptoms or symptoms such as shortness of breath, hold wheezing, wet rales, cough disappeared time were significantly shorter than that in the control group, the difference was statistically significant (P<0.05).Conclusion Inhalation of ambroxol hydrochloride in the treatment of infantile bronchitis has better clinical efficacy, can effectively shorten the bronchitis associated symptoms and signs, safe and effective, worthy of clinical application.%目的:探讨盐酸氨溴索与氢化可的松琥珀酸钠在治疗毛细支气管炎的临床疗效。方法选取我院2014年1月~2015年9月收治的毛细支气管炎患者共120例,按照随机数字表法分为对照组与观察组,两组患者均接受常规支气管炎治疗与护理,对照组患儿接受氢化可的松琥珀酸钠治疗,观察组患儿选择盐酸氨溴索治疗。治疗结束后比较两组患者治疗毛细支

  10. 孟鲁司特联合沙美特罗替卡松治疗218例支气管炎哮喘的可行性探究%The Feasibility Study of the Treatment of 218 Cases of Bronchitis Asthma by Montelukast Combined with Salmeterol

    Institute of Scientific and Technical Information of China (English)

    高晓婷

    2015-01-01

    目的:探讨孟鲁司特联合沙美特罗替卡松治疗支气管炎哮喘临床疗效。方法选取218例支气管炎患者作为研究对象,分为观察组对照组,各109例。观察组采用孟鲁斯特联合沙美特罗替卡松;对照组采用沙美特罗替卡松。比较两组肺功能情况和不良反应情况。结果观察组治疗有效率为94.4%,对照组为82.6%,差异具有统计学意义(P <0.05)。观察组治疗后肺功能改善情况优于对照组。结论采用孟鲁司特联合沙美特罗替卡松治疗支气管炎哮喘具有临床效果。%Objective To study clinical curative effect of montelukast combined with Shah Mette Lo Tikason to treat bronchitis asthma.MethodsTo choose 218 cases of bronchitis patients as the research object.They were divided into the observation group and the control group.The observation group treated with meng LuSi combined with salmeterol. The control group used salmeterol .Results The observation group treatment effective rate was 94.4%,the control group was 82.6%,and the difference statisticaly significant(P < 0.05).Conclusion The meng LuSi combined with salmeterol for treatment of bronchitis asthma is worthy of popularization and application.

  11. 小儿支气管炎急性发作应用阿奇霉素的临床治疗效果观察%Observation on the Clinical Effect of Azithromycin in the Treatment of Children With Acute Bronchitis

    Institute of Scientific and Technical Information of China (English)

    李海涛

    2015-01-01

    目的:分析研究小儿支气管炎急性发作通过阿奇霉素进行治疗的方法以及治疗效果,为临床提供依据。方法选取2013年3月~2014年3月小儿支气管炎急性发作患者资料88例实施回顾性分析。结果观察组患者治疗效果高于对照组患者,不良反应发生几率低于对照组患者(P <0.05),具有统计学意义。结论针对小儿支气管炎急性发作通过阿奇霉素进行治疗效果明显,患者出现不良反应几率小,属于一类安全有效的抗菌药物。%Objective To analyze and study the methods and therapeutic effect of the treatment of acute bronchitis acute attack of children, and provide the basis for clinical treatment. Methods A retrospective analysis was carried out on 88 cases of acute exacerbation of children's bronchitis from March 2013 to March 2014. Results The therapeutic effect of the observation group was significantly higher than that of the control group, the incidence of adverse reactions was significantly lower than that of the control group (P < 0.05), with statistical significance. Conclusion In the treatment of children with acute bronchitis acute attack by the effect of treatment, patients with small adverse reactions, is a kind of safe and effective antibacterial drugs.

  12. Clinical observation of Montelukast combined with Procaterol in treating pediatric asthmat-ic bronchitis%孟鲁司特联合丙卡特罗佐治小儿喘息性支气管炎的临床观察

    Institute of Scientific and Technical Information of China (English)

    严淑颜; 戴汝均

    2015-01-01

    AIM:To evaluate the efficacy of Montelukast com-bined with Procaterol in treating pediatric asthmatic bronchitis. METHODS:60 cases with asthmatic bronchitis were divided into treatment group (30 cases)and control group (30 cases)ran-domly.The control group received routine treatment,while the treatment group received oral Montelukast and Procaterol on the basic of routine therapy.RESULTS:The disappeared time of symptoms and signs in treatment group was significantly better than that in control group.CONCLUSION:Oral Montelukast combined with Procaterol has significantly curative effect in the treatment of pediatric asthmatic bronchitis.%目的:观察孟鲁司特联合丙卡特罗治疗小儿喘息性支气管炎的疗效。方法:选择喘息性支气管炎患儿60例,随机分为治疗组(30例)和对照组(30例)。对照组接受常规治疗,治疗组在常规治疗的同时口服孟鲁司特与丙卡特罗治疗。结果:治疗组症状、体征消失时间等方面均明显优于对照组。结论:口服孟鲁司特联合丙卡特罗治疗小儿喘息性支气管炎疗效显著。

  13. ANALYSIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH CLINICAL PARAMETERS, ECG AND ECHO

    Directory of Open Access Journals (Sweden)

    Satish

    2014-10-01

    Full Text Available BACK GROUND: Chronic obstructive pulmonary disease (COPD is a leading cause of morbidity and mortality in countries of high, middle, and low income. Estimates from WHO’s Global Burden of Disease and Risk Factors project show that in 2001, COPD was the fifth leading cause of death in high-income countries, accounting for 3.8% of total deaths, and it was the sixth leading cause of death in nations of low and middle income, accounting for 4·9% of total deaths. OBJECTIVES: 1. To study clinical parameters of chronic obstructive pulmonary disease. 2. To find out Electrocardiographic changes of chronic obstructive pulmonary disease. 3. To confirm with echocardiogram the presence of pulmonary hypertension, tricuspid regurgitation and right heart failure and analyze the incidence of right heart failure and pulmonary hypertension. MATERIALS AND METHODS: Single center hospital based cross sectional study. Patients diagnosed as COPD based on following steps will be included in the study. The patients with cough, sputum production, dyspnoea (wheeze was chosen (sputum AFB negative will be confirmed. Pulmonary function test was done to pick up patients with reduced FEV9 mm, as this is the one of the indication for life long oxygen therapy as per American Thoracic Society (ATS. Out of 72 patients, 12 had coronary artery disease (CAHD as this increases the incidence of cor-pulmonale. CARDIOVASCULAR COMPLICATIONS: Out of 72 patients, 24% developed pulmonary hypertension, 22% developed tricuspid regurgitation, 34% had p-pulmonale, 18% had p-wave amplitude in lead-II + lead-III + lead a VF >9 mm, this is important because this is one of the indication for life long oxygen therapy. 18% had concomitant coronary artery disease (CAHD, this observation is important because systemic inflammation plays enhanced role in atherosclerosis, diabetes mellitus, tumour necrosis factor is increased in COPD patients. CONCLUSION: Pulmonary hypertension was the most common

  14. Chronic diseases and mental disorder.

    NARCIS (Netherlands)

    Verhaak, P.F.M.; Heijmans, M.J.W.M.; Peters, L.; Rijken, M.

    2005-01-01

    The aim of this study was to achieve a better understanding of the relationship between chronic medical illness and mental distress. Therefore, the association between chronic medical illness and mental distress was analysed, taking into account the modifying effects of generic disease characteristi

  15. Anemia in Chronic Kidney Disease

    Science.gov (United States)

    ... High Blood Pressure Heart Disease Mineral & Bone Disorder Anemia in Chronic Kidney Disease What is anemia? Anemia is a condition in which the body ... function as well as they should. How is anemia related to chronic kidney disease? Anemia commonly occurs ...

  16. Chronic Kidney Disease and Medicines

    Science.gov (United States)

    ... from our online catalog. Alternate Language URL Español Chronic Kidney Disease and Medicines: What You Need to Know Page ... What you need to know Because you have chronic kidney disease, you should take steps to protect your kidneys. ...

  17. Obinutuzumab in chronic lymphocytic leukemia.

    Science.gov (United States)

    Dupuis, Jehan

    2015-09-01

    Obinutuzumab is the second next-generation monoclonal anti-CD20 antibody (after ofatumumab) to enter clinical practice in chronic lymphocytic leukemia. Its superiority in association with chlorambucil as compared with chlorambucil alone has led to its approval as a first-line treatment for chronic lymphocytic leukemia, for patients who are not candidates for a more intensive treatment.

  18. [Histopathologic study of chronic sinusitis].

    Science.gov (United States)

    Wayoff, M; Parache, R M; Bodelet, B; Gazel, P

    1983-01-01

    The conventional histopathology of the sinus is a criterium for the therapeutic indication, since it is possible to distinguish between granulomatous chronic sinusitis, chronic sinusitis with oedema and nasal polyposis. Each one of these clinical pictures has his own etiology and requires a specific therapeutic approach.

  19. [Chronic pyelonephritis in polycystic kidney].

    Science.gov (United States)

    Todorov, V; Penkova, S; Monov, A

    1989-01-01

    The characteristics of chronic pyelonephritis are studied in 37 patients out of a total of 53 patients with proved renal polycystosis. A group of 71 patients with chronic pyelonephritis selected at random are used as a control group. The frequency of chronic pyelonephritis among the patients with renal polycystosis is 69.8%. The difference between the mean age of the patients with renal polycystosis and chronic pyelonephritis and the patients with renal polycystosis without chronic pyelonephritis is 8.6 years. A significant difference is established between these two groups of patients concerning the frequency of symptomatic hypertension--89.2% for the patients with renal polycystosis and chronic pyelonephritis and 45% for the patients with uncomplicated renal polycystosis. A similar difference is established also for the renal failure--respectively 64.9% and 37.5%. The frequency of hypertension and chronic renal failure is lower in the control group of patients. 59% of the patients with renal polycystosis and chronic pyelonephritis have significant bacteriuria, E. coli and Proteus being the most frequently isolated bacteria but Pseudomonas shows the highest drug resistance. The isolated bacteria are most sensitive to nitroxoline and aminoglycoside antibiotics.

  20. Pharmacologic Agents for Chronic Diarrhea

    OpenAIRE

    Lee, Kwang Jae

    2015-01-01

    Chronic diarrhea is usually associated with a number of non-infectious causes. When definitive treatment is unavailable, symptomatic drug therapy is indicated. Pharmacologic agents for chronic diarrhea include loperamide, 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists, diosmectite, cholestyramine, probiotics, antispasmodics, rifaximin, and anti-inflammatory agents. Loperamide, a synthetic opiate agonist, decreases peristaltic activity and inhibits secretion, resulting in the reductio...