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Sample records for bronchitis chronic

  1. Chronic bronchitis in an elderly population

    DEFF Research Database (Denmark)

    Lange, Peter; Parner, Jan; Prescott, Eva;

    2003-01-01

    in order to describe the prevalence and prognostic implications of chronic bronchitis in individuals 65 years or older we analysed data from The Copenhagen City Heart Study.......in order to describe the prevalence and prognostic implications of chronic bronchitis in individuals 65 years or older we analysed data from The Copenhagen City Heart Study....

  2. Chronic Obstructive Pulmonary Disease (COPD) Includes: Chronic Bronchitis and Emphysema

    Science.gov (United States)

    ... Obstructive Pulmonary Disease (COPD) Includes: Chronic Bronchitis and Emphysema Recommend on Facebook Tweet Share Compartir Data are ... of adults who have ever been diagnosed with emphysema: 3.4 million Percent of adults who have ...

  3. A controlled trial of ambroxol in chronic bronchitis.

    Science.gov (United States)

    Guyatt, G H; Townsend, M; Kazim, F; Newhouse, M T

    1987-10-01

    Ambroxol is a mucolytic agent which is widely used in chronic bronchitis in Europe. We conducted a double-blind randomized controlled trial of ambroxol vs matched placebo in 90 patients with chronic bronchitis and difficulty clearing secretions. It was concluded that there was no advantage to taking ambroxol.

  4. Hydrator Therapies for Chronic Bronchitis. Lessons from Cystic Fibrosis.

    Science.gov (United States)

    Bennett, William D; Henderson, Ashley G; Donaldson, Scott H

    2016-04-01

    Patients with the chronic bronchitis form of chronic obstructive pulmonary disease and cystic fibrosis share similar clinical features, including mucus obstruction of airways and the development of chronic/recurrent airways infections that often manifest as disease exacerbations. There is growing evidence that these diseases may have parallels in disease pathogenesis as well, including cystic fibrosis transmembrane conductance regulator dysfunction, mucus dehydration, and defective mucociliary clearance. As progress is made in the development of therapies that target the basic defects that lead to cystic fibrosis lung disease, it is possible that similar approaches could also benefit patients with chronic bronchitis. A deeper understanding of how tobacco smoke and other triggers of chronic bronchitis actually lead to disease, and exploration of the concept that therapies that restore cystic fibrosis transmembrane conductance regulator function, mucus hydration, and/or mucociliary clearance may benefit patients with chronic bronchitis, hold the prospect of significant progress in treating this prevalent disease. PMID:27115955

  5. Risk of chronic bronchitis in twin pairs discordant for smoking

    DEFF Research Database (Denmark)

    Meteran, Howraman; Thomsen, Simon Francis; Harmsen, Lotte;

    2012-01-01

    It is well known that smoking is a major risk factor for lung disease and respiratory symptoms. We examined the association between smoking and the risk of chronic bronchitis in a large twin sample....

  6. Features of Chronic Bronchitis in Different Age Groups

    Directory of Open Access Journals (Sweden)

    Galina L. Ignatova

    2014-03-01

    Full Text Available Background: Lung diseases are assuming greater relevance and importance today. Chronic bronchitis is a self-nosology, which may precede the development of COPD, the importance of which can hardly be overestimated. The main problem in this disease is caused by late diagnosis and treatment due to the delay by patients in seeking medical help. The aim of the work was to study the distribution and exposure to tobacco smoke, especially chronic bronchitis, depending on various factors, including age. Methods: We examined 1779 persons, including 855 men and 924 women. The mean age of the population was 35.83±8.3 years. We conducted surveys and spirometry. The outcome was assessed after a bronchodilation test was performed with salbutamol 400 mcg. We performed all statistical analysis using software package Statistica 10. Results: We identified chronic bronchitis in 9.2% of the cases in the group of younger individuals and in 14.9% of the cases in the group of older individuals, during the active detection of chronic bronchitis using questionnaires. The prevalence of cigarette smoking was slightly higher among the younger (39.5% than the older persons (33.6%; the frequency of smoking in a group of chronic bronchitis was reliably higher. Also, in this group, the performance spirometry reliably decreased. Conclusions: Outpatient survey is an effective method of identifying chronic bronchitis. Smoking is a major risk factor in the group of young respondents and the prevalence of smoking is inversely related to the education level of the respondents, regardless of age. As the decline in the Forced Expiratory Volume (FEV1 and FEV1/FVC is the main criterion diagnosis of COPD, it revealed significant declines in the FEV1 of the younger smoking individuals, which may help to predict the development of COPD in the older age group.

  7. Acute Bronchitis

    Science.gov (United States)

    ... of bronchitis: acute and chronic. Most cases of acute bronchitis get better within several days. But your cough ... that cause colds and the flu often cause acute bronchitis. These viruses spread through the air when people ...

  8. A ferret model of COPD-related chronic bronchitis

    Science.gov (United States)

    Raju, S. Vamsee; Kim, Hyunki; Byzek, Stephen A.; Tang, Li Ping; Trombley, John E.; Jackson, Patricia; Rasmussen, Lawrence; Wells, J. Michael; Libby, Emily Falk; Winter, Lindy; Samuel, Sharon L.; Zinn, Kurt R.; Blalock, J. Edwin; Schoeb, Trenton R.; Dransfield, Mark T.; Rowe, Steven M.

    2016-01-01

    Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the US. The majority of COPD patients have symptoms of chronic bronchitis, which lacks specific therapies. A major impediment to therapeutic development has been the absence of animal models that recapitulate key clinical and pathologic features of human disease. Ferrets are well suited for the investigation of the significance of respiratory diseases, given prior data indicating similarities to human airway physiology and submucosal gland distribution. Here, we exposed ferrets to chronic cigarette smoke and found them to approximate complex clinical features of human COPD. Unlike mice, which develop solely emphysema, smoke-exposed ferrets exhibited markedly higher numbers of early-morning spontaneous coughs and sporadic infectious exacerbations as well as a higher level of airway obstruction accompanied by goblet cell metaplasia/hyperplasia and increased mucus expression in small airways, indicative of chronic bronchitis and bronchiolitis. Overall, we demonstrate the first COPD animal model exhibiting clinical and pathologic features of chronic bronchitis to our knowledge, providing a key advance that will greatly facilitate the preclinical development of novel treatments for this disease. PMID:27699245

  9. 77 FR 59929 - Guidance for Industry on Acute Bacterial Exacerbations of Chronic Bronchitis in Patients With...

    Science.gov (United States)

    2012-10-01

    ... August 22, 2008 (73 FR 49684), which in turn revised the draft guidance for industry entitled ``Acute... ``Acute Bacterial Exacerbations of Chronic Bronchitis in Patients With Chronic Obstructive Pulmonary... treatment of acute bacterial exacerbations of chronic bronchitis in patients with chronic...

  10. [Chronic bronchitis and its sequelae. Therapy--prognosis--insurance medicine aspects].

    Science.gov (United States)

    Gillissen, A; Schmidt, E W

    1996-12-01

    Chronic bronchitis is of enormous epidemiological, socio-medical and economical importance. The main cause of chronic bronchitis is active but also passive cigarette smoking. Other etiologic factors are: viral or bacterial infections, chronic dust exposure in occupational settings and air pollution. Cease of cigarette smoking is considered the most valuable action in the treatment of the chronic bronchitis. In addition to drug therapy, physical therapy and other measures of rehabilitation may be a supportive benefit. ABout 10-20% of all patients with chronic bronchitis develop airway obstruction and/or lung emphysema. Obstructive bronchitis with or without lung emphysema should be treated with corticosteroids, beta 2-agonists and/or theophylline. Evidence for the socio-economical burden of chronic bronchitis and its complications are the enormous costs for the social economy (direct costs: in- and outpatient treatment; indirect costs: premature pensions, sick leave). PMID:9082644

  11. Factors affecting the decline of ventilatory function in chronic bronchitis.

    OpenAIRE

    Campbell, A H; Barter, C. E.; O'Connell, J M; Huggins, R

    1985-01-01

    Ninety six middle aged male patients with chronic bronchitis with relatively well preserved ventilatory function who were resident in Queensland, New South Wales, or Victoria took part in a prospective study to determine the relationship of various factors to the rate of decline of the FEV1. Thirty of the subjects withdrew, leaving 66 to be followed for four to six years. The mean rate of decline of the FEV1 was 58.6 (SD 51.4) ml/year. The subjects' ventilatory responses to bronchodilator and...

  12. Chronic bronchitis in West Sweden – a matter of smoking and social class

    Directory of Open Access Journals (Sweden)

    Malin Axelsson

    2016-07-01

    Full Text Available Background: Although chronic bronchitis is associated with impaired quality of life, hospitalisations and increased mortality, it has been less in focus after the introduction of the term chronic obstructive pulmonary disease (COPD. There are no recent published data on the prevalence of chronic bronchitis from the Scandinavian countries. Aim: The main aim of the present study was to estimate the prevalence of chronic bronchitis in West Sweden by using data from a large-scale epidemiological study of the general population. A further aim was to identify current risk factors for chronic bronchitis in a population with a major decrease in the proportion of smokers. Methods: From the 18,087 questionnaire responders out of 30,000 invited to participate at the West Sweden Asthma Study, 2,000 subjects were randomly selected and invited to detailed clinical examinations performed during 2009–2013. A total of 1,172 subjects aged 17–79 participated in the examinations which included, among others, spirometry and structured interviews. Chronic bronchitis was defined according to reported symptoms. Results: The overall prevalence of chronic bronchitis was 7.2% (men 7.6%; women 6.8% ns, and it was 8.7% in subjects older than age 60. Chronic bronchitis was strongly associated with smoking, defined both as current smoking status and pack-years. Other risk factors were increasing age, low socio-economic class and urban living. Of those with chronic bronchitis, 22% fulfilled the GOLD criteria of COPD. Conclusion: The prevalence of chronic bronchitis was somewhat lower than found by studies in Sweden in the 1980s and the prevalence was now similar in men and women. Although smoking was still the dominating risk factor for chronic bronchitis, the relative importance of smoking had decreased parallel with a decreasing smoking prevalence, while the relative importance of other factors than smoking had increased compared to previous studies.

  13. Chronic bronchitis in West Sweden – a matter of smoking and social class

    Science.gov (United States)

    Axelsson, Malin; Ekerljung, Linda; Eriksson, Jonas; Hagstad, Stig; Rönmark, Eva; Lötvall, Jan; Lundbäck, Bo

    2016-01-01

    Background Although chronic bronchitis is associated with impaired quality of life, hospitalisations and increased mortality, it has been less in focus after the introduction of the term chronic obstructive pulmonary disease (COPD). There are no recent published data on the prevalence of chronic bronchitis from the Scandinavian countries. Aim The main aim of the present study was to estimate the prevalence of chronic bronchitis in West Sweden by using data from a large-scale epidemiological study of the general population. A further aim was to identify current risk factors for chronic bronchitis in a population with a major decrease in the proportion of smokers. Methods From the 18,087 questionnaire responders out of 30,000 invited to participate at the West Sweden Asthma Study, 2,000 subjects were randomly selected and invited to detailed clinical examinations performed during 2009–2013. A total of 1,172 subjects aged 17–79 participated in the examinations which included, among others, spirometry and structured interviews. Chronic bronchitis was defined according to reported symptoms. Results The overall prevalence of chronic bronchitis was 7.2% (men 7.6%; women 6.8% ns), and it was 8.7% in subjects older than age 60. Chronic bronchitis was strongly associated with smoking, defined both as current smoking status and pack-years. Other risk factors were increasing age, low socio-economic class and urban living. Of those with chronic bronchitis, 22% fulfilled the GOLD criteria of COPD. Conclusion The prevalence of chronic bronchitis was somewhat lower than found by studies in Sweden in the 1980s and the prevalence was now similar in men and women. Although smoking was still the dominating risk factor for chronic bronchitis, the relative importance of smoking had decreased parallel with a decreasing smoking prevalence, while the relative importance of other factors than smoking had increased compared to previous studies. PMID:27421832

  14. Prevalence and risk factors for chronic bronchitis and farmer's lung in French dairy farmers.

    OpenAIRE

    Dalphin, J.C.; Debieuvre, D.; Pernet, D.; Maheu, M F; Polio, J. C.; Toson, B.; Dubiez, A.; Monnet, E; Laplante, J. J.; Depierre, A

    1993-01-01

    The prevalence of chronic bronchitis and of clinical farmer's lung was studied in 30 districts of the French Doubs province in relation to individual (age, sex, smoking) and geographical (altitude) factors. 5703 exclusively dairy farmers (response rate 83%) participated in the study by answering a medical questionnaire. Prevalences of chronic bronchitis and clinical farmer's lung were 9.3% and 1.4% respectively. A logistic regression model was used to evaluate risk factors for chronic bronchi...

  15. STUDY ON INFLAMMATORY CELLS IN BALF OF SMOKE-INDUCED CHRONIC BRONCHITIS RAT MODEL

    Institute of Scientific and Technical Information of China (English)

    李庆云; 黄绍光; 吴华成; 程齐俭; 项轶; 万欢英

    2004-01-01

    Objective To establish a smoke-induced chronic bronchitis rat model and evaluate the pathological change semi-quantitatively, and study the characteristics of the inflammatory cells in the bronchoalveolar lavage fluid (BALF) in various stages. Methods Chronic bronchitis sequential rat model was established by passively inhaling smoke mixture. Experiments were performed in 30 young male Sprague-Dawley rats, which comprised 5 groups in random, i.e.,4 chronic bronchitis model groups and I control group. After stained with hematoxylin and eosin, the specimens were studied by semi-quantitative method to evaluate the morphologic changes in various stages. Meanwhile, the inflammatory cells of the BALF and the activity of myeloperoxidase ( MPO ) of lung tissue were analysed. Results During the process of the chronic bronchitis, the pathologic score was increasing as time went on, and the typical morphologic changes of chronic bronchitis emerged in the group 7 weeks. The total number of inflammatory cells in BALF was increasing as time went on, correlated with the pathologic scores ( P < 0. 01 ).And the percentage of lymphocyte increased as well as positively correlated with pathologic scores ( P < 0. 05 ),whereas that of macrophage decreased and negatively correlated with pathologic scores (P <0. 05). The MPO lever of lung tissue was correlated with the pathologic scores ( P < 0. 01 ). But the percentage of the neutrophil in the BALF was just in a high level during the first week, then it maintained relatively lower. Conclusion Smoke-induced chronic bronchitis is a slowly progressive inflammation process. The model we established is convenient and simple for the longitudinal study on the inflammatory process of chronic bronchitis and the therapy in the early stage. The semi-quantitative evaluation for the pathological change is with much more value. During the inflammatory sequential process of early stage of chronic bronchitis, the cellular characteristics are

  16. [Features of chronic occupational bronchitis in nonferrous metallurgy workers].

    Science.gov (United States)

    Roslaia, N A; Likhacheva, E I; Vagina, E R; Roslyĭ, O F; Zhovtiak, E P; Iarina, A L; Varzina, N V

    2004-01-01

    The authors summarized results of periodic medical examinations and deep clinical studies of metallurgy workers with bronchial and pulmonary disorders. The article covers clinical and functional characteristics of toxic and dust bronchitis, clinical course and manifestations.

  17. Study on the serum thyroid hormones levels in patients with acute and chronic bronchitis

    International Nuclear Information System (INIS)

    Objective: To study the changes of serum thyroid hormones levels in patients with acute bronchitis and chronic bronchitis. Methods: Serum T3, FT3, T4, FT4, TSH (with CLIA) and rT3 (with RIA) levels were measured in 107 patients with acute bronchitis, 87 patients with chronic bronchitis and 47 controls. Results: The serum thyroid hormones levels in all these patients were not significantly different from those in controls (P>0.05), except that the serum T3 levels were significantly lower and rT3 levels significantly higher (P3 levels increased significantly and rT3 levels decreased significantly after treatment (P3 levels could reflect the severity of the disease, the T3/rT3 ratio was lowest in the 10 deceased patients. (authors)

  18. Psychological Distress in Women with Chronic Bronchitis in a Fishing Community in the Niger Delta Region of Nigeria

    Directory of Open Access Journals (Sweden)

    Victor Aniedi Umoh

    2013-01-01

    Full Text Available Background. Biomass smoke exposure is a known risk factor for chronic bronchitis. Psychiatric comorbidities may have significant impact on the quality of life of patients with chronic bronchitis. Methods. Women who engage in fish preservation by drying over burning firewood in a fishing community were recruited for this survey. The British medical research questionnaire was used to determine chronic bronchitis, and psychological distress was determined using the hospital anxiety and depression scale. Results. A total of 342 women were recruited for this study and 63 of them had chronic bronchitis. 96 women had features suggestive of psychological distress: 57 (16.6% women with anxiety, 51 (14.9% women with depression and 12 women (3.5% had combined features. Psychological distress was more common among women with chronic bronchitis. Anxiety was significantly associated with chronic bronchitis and the level of biomass exposure while depression was significantly associated with chronic bronchitis, level of exposure, and a history of sleeping in the fish smoking room. Conclusion. Anxiety and depression show significant association with chronic bronchitis among women with biomass smoke exposure with the level of exposure having an aggravating effect on the relationship.

  19. Nebuhaler or nebulizer for high dose bronchodilator therapy in chronic bronchitis: a comparison.

    Science.gov (United States)

    Allen, M B; Pugh, J; Wilson, R S

    1988-10-01

    We have compared the clinical efficacy of high dose terbutaline sulphate (10 mg four times daily) delivered by either a Nebuhaler or jet nebulizer in 13 patients with chronic bronchitis in a 2-week, open, crossover study. Both treatment regimens improved run-in symptom scores but no significant changes were recorded in peak flow and spirometry. Side-effects were more common with the Nebuhaler and more patients preferred the nebulizer. However, the Nebuhaler is an alternative therapeutic option for delivery of high doses of bronchodilators in patients with chronic bronchitis. PMID:3076792

  20. Radionuclide methods of assessment of external respiration in chronic obstructive bronchitis

    International Nuclear Information System (INIS)

    A trial was designet to study shifts in various mechanisms of external respiration (ER)distress in chronic obstructive bronchitis by type of respiration insufficiency (RI). Combinet clinicoroentgenological, spirographic, endoscopic and radionuclide (133Xe radiopneumography and 99Tc scintigraphy) examinations were conducted in 66 patients. The following parameters appeared most informative in studying ER in the bronchitis patients with radionuclide techniques: the volume of ventilated alveoli, respiratory capacity, total and functional residual lung capacity, index ventilation/blood flow, capillary blood flow, time of half elimination of Xe from the alveoli and vascular bed. The above parameters change for the worse with progressive deterioration of external respiration

  1. Exposure to Outdoor Air Pollution and Chronic Bronchitis in Adults: A Case-Control Study

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    M Waked

    2012-09-01

    Full Text Available Background: Although Lebanon is a highly polluted country, so far no study has specifically been designed to assess the association between outdoor air pollution and chronic bronchitis in this country.Objective: To assess the association between exposure to outdoor air pollution and chronic bronchitis in Lebanon. Methods: A pilot case-control study was conducted in two tertiary care hospitals. Cases consisted of patients diagnosed with chronic bronchitis by a pulmonologist and those epidemiologically confirmed. Controls included individuals free of any respiratory signs or symptoms. After obtaining informed consent, a standardized questionnaire was administered.Results: Bivariate, stratified (over smoking status and gender and multivariate analyses revealed that passive smoking at home (ORa: 2.56, 95% CI: 1.73–3.80 and at work (ORa: 1.89, 95% CI: 1.13–3.17; older age (ORa: 1.75, 95% CI: 1.55–2.39; lower education (ORa: 1.44, 95% CI: 1.21–1.72; living close to a busy road (ORa: 1.95, 95% CI: 1.31– 2.89 and to a local power plant (ORa: 1.62, 95% CI: 1.07–2.45; and heating home by hot air conditioning (ORa: 1.85, 95% CI: 1.00–3.43 were moderately associated with chronic bronchitis; an inverse association was found with heating home electrically (ORa: 0.58, 95% CI: 0.39–0.85. A positive dose-effect relationship was observed in those living close to a busy road and to a local diesel exhaust source.Conclusion: Chronic bronchitis is associated with outdoor air pollution.

  2. Correlates of COPD and chronic bronchitis in nonsmokers: data from a cross-sectional study

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    Khayat G

    2012-09-01

    Full Text Available Mirna Waked,1 Joseph Salame,2 Georges Khayat,3 Pascale Salameh41Faculty of Medicine, Balamand University, and St George Hospital, Beirut, Lebanon; 2Lebanese University, Faculty of Medicine, Beirut, Lebanon; 3Faculty of Medicine, St Joseph University and Hôtel Dieu de France Hospital, Beirut, Lebanon; 4Lebanese University, Faculties of Pharmacy and Public Health, Beirut, LebanonPurpose: Our objective was to assess the prevalence of chronic bronchitis and chronic obstructive pulmonary disease (COPD and their correlates among a Lebanese nonsmoker group.Material and methods: A cross-sectional study was conducted between October 2009 and September 2010, using a multistage cluster sample throughout Lebanon including Lebanese residents aged 40 years and above with no exclusion criteria. Pre- and postbronchodilator spirometry measurements were performed and carbon monoxide level was measured in exhaled air. COPD was defined and classified according to the Global Initiative for Chronic Obstructive Lung Disease guidelines or according to the lower limit of normal (forced expiratory volume in 1 second/forced vital capacity postbronchodilator < 5th percentile of the healthy population having the same age and sex. Chronic bronchitis was defined by the declaration of morning cough and expectorations for more than 3 months a year over more than 2 years in individuals with normal spirometry.Results: Out of 2201 individuals, 732 were never-smokers: 25 (3.4% of them had COPD, and 86 (11.75% fulfilled the definition of chronic bronchitis. Correlates of COPD included a childhood respiratory disease, house heated by diesel, and older age. On the other hand, correlates of chronic bronchitis included childhood respiratory diseases, living in southern Lebanon versus other regions, heating home by gas, older age, number of smokers at work, and lower height.Conclusion: A substantial percentage of the nonsmoking population may exhibit chronic bronchitis or COPD. The

  3. Moxifloxacin in the management of exacerbations of chronic bronchitis and COPD

    OpenAIRE

    Miravitlles, Marc

    2007-01-01

    Bacteria are isolated in more than 50% of exacerbations of chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD). The most prevalent respiratory pathogens include Gram-positive (Streptococcus pneumoniae) and Gram-negative (Haemophilus influenzae, Moraxella catarrhalis) microorganims. Moxifloxacin is a fourth-generation fluoroquinolone that has been shown to be effective against respiratory pathogens, including atypicals and those resistant to most common antibiotics. The bi...

  4. Impact of heterozygote CFTR Mutations in COPD patients with Chronic Bronchitis

    OpenAIRE

    Raju, S. Vamsee; Tate, Jody H; Peacock, Sandra KG; Fang, Ping; Oster, Robert A.; Dransfield, Mark T.; Steven M Rowe

    2014-01-01

    Background Cigarette smoking causes Chronic Obstructive Pulmonary Disease (COPD), the 3rd leading cause of death in the U.S. CFTR ion transport dysfunction has been implicated in COPD pathogenesis, and is associated with chronic bronchitis. However, susceptibility to smoke induced lung injury is variable and the underlying genetic contributors remain unclear. We hypothesized that presence of CFTR mutation heterozygosity may alter susceptibility to cigarette smoke induced CFTR dysfunction. Con...

  5. Growth, Nutritional Status, and Pulmonary Function in Children with Chronic Recurrent Bronchitis.

    Science.gov (United States)

    Umławska, Wioleta; Lipowicz, Anna

    2016-01-01

    Bronchitis is a common health problem in children. Frequent bronchitis in infancy increases the risk of developing chronic respiratory diseases. The aim of the study was to assess the level of growth and the nutritional status in children and youths with special regard to the level of body fatness assessed by measuring skin-fold thickness. Relationships between somatic development, pulmonary function and the course of the disease were also explored. The study was carried out using anthropometric and spirometric measurements and also information on the severity and course of the disease in 141 children with chronic or recurrent bronchitis. All of the subjects were patients of the Pulmonary Medicine and Allergology Center in Karpacz, Poland. The mean body height did not differ significantly between the children examined and their healthy peers. However, the infection-prone children had excessive body fatness and muscle mass deficiency. The increased level of subcutaneous adipose tissue occurred especially in children with short duration of the disease, i.e. a maximum of 1 year. The functional lung parameters were generally normal. The presence of atopic diseases such as allergic rhinitis or atopic dermatitis did not impair the course of the children's somatic development. Also, long-term disease or the presence of additional allergic diseases did not impair lung function in the examined children. Taking appropriate preventive measures is recommended to achieve and maintain normal body weight in children who receive therapy due to bronchitis.

  6. Effect of smoking cessation on airway inflammation of rats with chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    LI Qing-yun; HUANG Shao-guang; WAN Huan-ying; WU Hua-cheng; ZHOU Tong; LI Min; DENG Wei-wu

    2007-01-01

    Background Smoking is the major cause of airway inflammation in chronic obstructive pulmonary disease (COPD),and smoking cessation is regarded as one of the important strategies for prevention and treatment of the inflammation.The inflammation of the chronic airway may be present and deteriorated even if the COPD patients stop smoking.Whether and how early smoking cessation affects the progress of inflammation is still obscure. This study was conducted to find the appropriate time for smoking cessation to terminate the airway inflammation in rats with smoke-induced chronic bronchitis.Methods A rat model of COPD was established by passively inhaling smoke mixture. Fifty-four young male Sprague-Dawley rats were randomly divided into 9 groups with different periods of smoke exposure and different time points of cessation. The inflammation markers to be detected included inflammatory cells in the bronchoalveolar lavage fluid (BALF), the myeloperoxidose (MPO) activity, the morphologic changes and the expression of ICAM-1 on the airway epithelium.Results When smoking was terminated at early stage, the inflammatory markers and related indexes were different from those of the typical chronic bronchitis group (group M7) (P<0.01). The pathologic score of group SC7 (2 weeks of smoking cessation after occurrence of typical chronic bronchitis ) was not different from that of group M7, and the level of ICAM-1 was still up-regulated (compared to group M7, P>0.05). Meanwhile, most of inflammatory cells in BALF were neutrophils compared to other groups (P<0.01).When smoking was terminated, the MPO activity was significantly lower than that of group M7 (P<0.01).Conclusions Smoking cessation at early stage can effectively inhibit the inflammatory reaction of COPD. Once chronic bronchitis occurs, little could be improved by smoking cessation.

  7. Comparison of right ventricular weight at necropsy in interstitial pulmonary fibrosis and in chronic bronchitis and emphysema.

    OpenAIRE

    Packe, G E; Cayton, R M; Edwards, C. W.

    1986-01-01

    The ventricular weights in 43 patients with interstitial pulmonary fibrosis were retrospectively compared with those in 172 patients with emphysema and chronic bronchitis. The mean right ventricular weight of patients with interstitial pulmonary fibrosis and those with emphysema and chronic bronchitis was 85.5 g (SD 23.2) and 88.8 g (34.3), respectively. Thirty five patients (81%) with interstitial pulmonary fibrosis had a right ventricular weight over 65 g compared with 124 (72%) of those wi...

  8. Investigation of Neurokinin‐1 Receptor Antagonism as a Novel Treatment for Chronic Bronchitis in Dogs

    OpenAIRE

    Grobman, M.; Reinero, C.

    2016-01-01

    Background Canine chronic bronchitis (CCB) results in cough lasting ≥2 months and airway inflammation. Adverse effects include risk of secondary infection associated with lifelong corticosteroid administration and prompt investigation into alternative therapies. Neurogenic pathways mediated by tachykinins that bind neurokinin (NK) 1 receptors may induce cough and airway inflammation. Maropitant,1 a NK‐1 receptor antagonist, has been advocated for treatment of CCB based on anecdotal improvemen...

  9. [Effects of essential oil on lipid peroxidation and lipid metabolism in patients with chronic bronchitis].

    Science.gov (United States)

    Siurin, S A

    1997-01-01

    Natural concentrations of some essential oils were examined for effects on the system lipid peroxidation-antioxidant defense and lipid metabolism in 150 patients with chronic bronchitis. Lowering of plasm levels of dienic conjugates and ketons, activation of catalase in red cells characteristic of antioxidant effect were observed in exposure to essential oils of rosemary, basil, fir, eucalyptus. Lavender essential oil promotes normalization of the level of total lipids, ratio of total cholesterol to its alpha-fraction. PMID:9490339

  10. Spirometric abnormalities associated with chronic bronchitis, asthma, and airway hyperresponsiveness among boilermaker construction workers

    Energy Technology Data Exchange (ETDEWEB)

    Hauser, R.; Eisen, E,A,; Pothier, L,; Lewis, D,; Bledsoe, T,; Christiani, D.C. [Harvard University, Boston, MA (United States). School of Public Health

    2002-06-01

    In a 2-year longitudinal study of boilermaker construction workers, authors found a significant association between working at oil-fired, coal-fired, and gas-fired industries during the past year and reduced lung function. In the present study, authors investigated whether chronic bronchitis, asthma, or baseline methacholine airway responsiveness can explain the heterogeneity in lung function response to boilermaker work. Exposure was assessed with a work history questionnaire. Spirometry was performed annually to assess lung function. A generalized estimating equation approach was used to account for the repeated-measures design. One hundred eighteen boilermakers participated in the study. Self-reported history of chronic bronchitis and asthma were associated with a larger FEV1 reduction in response to workplace exposure at coal-fired and gas-fired industries. Although a high prevalence (39%) of airway hyperresponsiveness (provocative concentration of methacholine causing a 20% fall in FEVI of {lt} 8 mg/mL) among boilermakers was found, there was no consistent pattern of effect modification by airway responsiveness. Conclusions: Although chronic bronchitis and asthma were associated with a greater loss in lung function in response to hours worked as a boilermaker, and therefore they acted as effect modifiers of the exposure-lung function relationship, airway hyperresponsiveness did not. However, the high prevalence of airway hyperresponsiveness found in the cohort may be a primary consequence of long-term workplace exposure among boilermakers.

  11. Clinical and radiological diagnosis of chronic pneumonia in pneumoconiosis and dust bronchitis

    International Nuclear Information System (INIS)

    Clinical and radiologic symptomatology of chronic pneumonia is described for pneumoconiosis and chronic dust bronchitis. Combined X-ray methods of examination permit the physicians to discover this complication in dust diseases of the lungs in the presence of diffuse pneumosclerotic changes in 76.5+-3 % of cases. These data approach the values of chronic pneumonia incidence among the population. Chronic pneumonia diagnosis should be complex. If no less than 2 to 3 X-ray signs of the disease have been found simultaneously, the significance of radiologic diagnosis of chronic pneumonia in dust pathology of the lungs, rises. Radiologic examination, supported by clinical, anamnestic and laboratory data, allows one to differentiate chronic pneumonia from coniotuberculosis. Chest X-rays in dust pathology of the lungs, complicated by chronic pneumonia, should be carried out with regard to clinical indications

  12. [Clinical trial of a Plantago major preparation in the treatment of chronic bronchitis].

    Science.gov (United States)

    Matev, M; Angelova, I; Koĭchev, A; Leseva, M; Stefanov, G

    1982-01-01

    Plantago major, according to literature data, has expectorant, antiphlogistic, pain-relieving effect. The experimental studies confirmed a spastic effect upon the smooth musculature of bronchi as well. Twenty five patients with chronic bronchitis were examined, with or without spastic character, with light and moderately severe deviations in ventilation indices. The treatment period was 25-30 days. A rapid effect on subjective complaints and objective findings was obtained in 80 per cent. Some indices of external respiration were favourably affected. The preparation is with a good tolerance, with no toxic effect on gastrointestinal tract, liver, kidneys, hemopoiesis. PMID:7101883

  13. Efficacy and Tolerability of 5- vs 10-Day Cefixime Therapy in Acute Exacerbations of Chronic Bronchitis.

    Science.gov (United States)

    Lorenz, J; Steinfeld, P; Drath, L; Keienburg, T; Troester, K

    1998-01-01

    The efficacy and tolerability of oral cefixime 400mg once daily for 5 days was compared with standard 10-day therapy in a multicentre, double-blind, randomised, controlled clinical trial of 222 patients with acute exacerbations of chronic bronchitis. Clinical and bacteriological efficacy were assessed after 6, 11 and 30 days. A total of 167 patients were evaluable for efficacy on a per-protocol basis. Clinical efficacy (cure or improvement based on the quality and quantity of expectorated sputum and symptoms of dyspnoea) at day 11 was statistically equivalent (p < 0.01) between the treatment groups, with a successful clinical response achieved in 91% (5-day) and 89% (10-day) of patients. Bacteriological efficacy was also similar with 5- and 10-day treatment. During treatment, more patients reported an adverse event possibly or probably related to the study medication in the 10-day than in the 5-day treatment group (19 vs 14%). However, this difference was not statistically significant. Oral cefixime 400mg once daily is an effective and well tolerated treatment for acute exacerbations of chronic bronchitis. Short-term (5-day) therapy offers clinical efficacy similar to that of standard (10-day) therapy. PMID:18370461

  14. Pro-Con Debate: Protracted Bacterial Bronchitis as a Cause of Chronic Cough in Children.

    Science.gov (United States)

    Bidiwala, Aneela; Krilov, Leonard R; Pirzada, Melodi; Patel, Sameer J

    2015-08-01

    Pro: Children with chronic cough present a diagnostic challenge. Protracted bacterial bronchitis (PBB) is a chronic, persistent bacterial infection of conducting airways defined by the presence of cough for longer than 4 weeks that resolves with antimicrobial therapy and without an alternative diagnosis. The diagnosis is made by the findings of increased bronchial secretions and edema of the lower airways on flexible bronchoscopy and positive cultures on bronchoalveolar lavage. It is speculated that an initial respiratory insult such as viral infection disrupts normal surface morphology and ciliary function, which leads to chronic self-perpetuating inflammation with the formation of bacterial biofilms, leading to PBB. PBB is often misdiagnosed as asthma, leading to inappropriate and excessive use of steroids. The importance of timely diagnosis should be emphasized due to the potential that PBB may be a precursor to chronic suppurative lung disease or bronchiectasis if left untreated; however, every patient should be adequately assessed to exclude other causes of chronic cough. Con: Clinical criteria for the diagnosis of PBB are nonspecific and may not distinguish it from other known causes of chronic cough, including viral infections. Benefits from antibiotic therapy (particularly prolonged therapy) have not been demonstrated. Respiratory conditions are the most common reason for antibiotic prescriptions during ambulatory visits in the United States, and many of these prescriptions are inappropriate and/or unnecessary. The proposed diagnostic criteria and recommendations for the treatment of PBB will lead to unnecessary overuse of antibiotics.

  15. Canadian Guidelines for the Management of Acute Exacerbations of Chronic Bronchitis

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    Meyer S Balter

    2003-01-01

    Full Text Available Acute exacerbations of chronic bronchitis (AECB account for over 1.5 million physician visits annually in Canada and are a cause of significant morbidity and mortality. This document represents a joint effort between respirologists, microbiologists, infectious disease specialists and family physicians to update the Canadian AECB guidelines published in 1994. Treatment recommendations are graded on the strength of evidence in the published literature where possible. The role for oral corticosteroid therapy in preventing treatment failures, speeding up recovery and delaying the time to next exacerbation is discussed. Risk factors for treatment failure were used to stratify patients into risk groups to help guide antibiotic treatment recommendations. The importance of emerging antimicrobial resistance to current antibiotics is reviewed and strategies to prevent future AECB episodes are suggested.

  16. Protective effect of a bacterial extract against acute exacerbation in patients with chronic bronchitis accompanied by chronic obstructive pulmonary disease

    Institute of Scientific and Technical Information of China (English)

    李靖; 郑劲平; 袁锦屏; 曾广翘; 钟南山; 林材元

    2004-01-01

    Background Immunostimulating agents made from bacterial extracts represent a class of medications that contains antigens derived from several bacterial strains and their potential ability to prevent bacterial infections results from the stimulation of the nonspecific component of the immune system. The present study investigated the effect of the oral immunostimulant Broncho-Vaxom, which includes material from eight different species of bacteria that are frequently present in the lower respiratory tract, on the frequency and severity of acute exacerbation in patients with chronic bronchitis accompanied by chronic obstructive pulmonary disease (COPD). Methods Ninety patients with chronic bronchitis complicated with COPD were randomly divided into groups A and B. Forty-nine subjects in group A received oral capsules containing 7mg Broncho-Vaxom, while 41 patients in group B received similar placebo capsules. Both groups took one capsule daily for the first 10 days of each month for 3 consecutive months. The frequency of acute exacerbation, symptom scores, and lung function were recorded for the following one year period.Results There was a significant decrease in the incidence, duration, and severity of acute exacerbation, as well as a reduction in the course of antibiotics administered and in the dosage of bronchodilator and mucolytic agent in group A, as compared to group B (P<0.05, respectively). Symptom scores for cough, sputum, dyspnea, as well as symptoms observed upon auscultation of the chest also improved significantly in group A as compared to group B (P<0.05, respectively). The bacterial clearance rate in sputum cultures from patients who received no antibiotics for the first 3 months was also significantly higher in group A compared to group B (P<0.01).Conclusions Orally administered Broncho-Vaxom is associated with a decrease in the incidence of acute exacerbation and a decrease in the need for antibiotics and symptomatic relief medications in patients

  17. Economic burden of chronic bronchitis in the United States: a retrospective case-control study

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    Christopher M Blanchette

    2011-01-01

    Full Text Available Christopher M Blanchette1, Melissa H Roberts1, Hans Petersen1, Anand A Dalal2, Douglas W Mapel31Division of Clinical and Outcomes Research, Lovelace Respiratory Research Institute, Kannapolis, NC, USA; 2US Health Outcomes, GlaxoSmithKline, Research Triangle Park, NC, USA; 3Lovelace Clinic Foundation, Albuquerque, NM, USABackground: Chronic bronchitis (CB is often misdiagnosed or diagnosed at a later stage of chronic obstructive pulmonary disease (COPD. We examined how this later diagnosis may impact health care costs and utilization during the 12 months prior to and 24 months post initial CB diagnosis.Methods: This retrospective case-control analysis used claims data from a large US database from July 1, 2003 through June 30, 2007. Patients with CB aged 40 years and older were propensity matched (N = 11,674 to patients without evidence of COPD or asthma by demographics, CB diagnosis quarter/year, and comorbidities. Group differences were assessed using Student's t-test and Pearson chi-square test statistics.Results: Six months prediagnosis, CB patients had higher frequencies of any hospitalization (9.6%, 6.7%; P < 0.05, emergency department/urgent care visits (13.3%, 6.7%; P < 0.05, and prescriptions (97.3%, 94.1%; P < 0.05. Six months postdiagnosis, CB patients had 5.6 times more hospitalizations (P < 0.05 and 3.1 times more emergency department/urgent care visits (P < 0.05 compared with controls. Mean total costs (US$ for CB patients 12 months prediagnosis were significantly higher than controls (months 12–7: $4212, $3826; P < 0.05; months 6–1: $5289, $4285; P < 0.05. CB patients had higher mean total costs ($8919; P < 0.05 6 months postdiagnosis. Costs remained $2429 higher for CB patients 19–24 months postdiagnosis (P < 0.05.Conclusion: Health care costs and utilization among CB patients are increased both prior to diagnosis and during the 2 years postdiagnosis. This study suggests that not accurately diagnosing CB early has a

  18. Bronchitis and Pneumonia

    Science.gov (United States)

    ... What is the difference between bronchitis and pneumonia? Bronchitis is most often a bacte- rial or viral infection that causes swelling of the tubes (bronchioles) leading to the lungs. Pneumonia is an acute or chronic disease marked by inflammation of the ...

  19. Bronchial brush biopsies for studies of epithelial inflammation in stable asthma and nonobstructive chronic bronchitis.

    Science.gov (United States)

    Riise, G C; Andersson, B; Ahlstedt, S; Enander, I; Söderberg, M; Löwhagen, O; Larsson, S

    1996-08-01

    Recently, bronchial brush biopsy (BBB) has been introduced as a complimentary method to bronchial forceps biopsy for the study of bronchial epithelial cells. We wanted to determine whether epithelial inflammatory cells in bronchial brush biopsies can reflect mucosal inflammation assessed indirectly by levels of cellular activation markers in bronchial lavage fluid. We studied 15 healthy controls, 11 asthmatics with regular steroid inhalation therapy, 13 asthmatics without steroids, and 10 smokers with nonobstructive chronic bronchitis. Differential counts of epithelial and inflammatory cells were made from the BBB material. Bronchial lavage levels of eosinophil cationic protein (ECP), myeloperoxidase (MPO), tryptase, hyaluronan and interleukin-8 (IL-8) were measured as indirect markers for inflammatory cell activation. We found an increased percentage of eosinophil granulocytes in the BBB from the steroid-untreated asthmatic patients (1.16%) in comparison to the other groups (0.11%, 0.09% and 0.02%, respectively; pairways disease. These changes appear to relate to the degree of inflammatory activity and disease severity in asthma. PMID:8866592

  20. Whether chronic bronchitis is an independent risk factor for cerebral infarction in the elderly 1:1 case paired study

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    BACKGROUND: The inflammatory reaction already becomes an important risk factor of causing acute cerebral infarction; however, the correlation between chronic bronchitis and senile cerebral infarction is still unclear.OBJECTIVE: To study whether the chronic bronchitis is the risk factor for senile cerebral infarction.DESIGN: 1:1 pair, case contrast, and risk factor study.SETTINGS: Department of Respiratory Medicine, Third Hospital of Tangshan; Department of Neurology,Affiliated Hospital of North China Coal Medical College.PARTICIPANTS: A total of 147 patients with acute cerebral infarction who were regarded as case group were selected from Department of Neurology, the Third Hospital of Tangshan from January 2004 to December 2006. All patients met the diagnostic criteria of the Fourth National Cerebrovascular Diseases Meeting. There were 87 males and 60 females, and their ages ranged from 65 to 83 years. Based on 1∶1 pair study, another 147 subjects without cerebrovascular disease were regarded as control group. Except the diseases about infection, there were 73 males and 74 females, and their ages ranged from 62 to 81 years. All subjects provided the confirm consent and agreed with the coordinate experiment.METHODS: ① Questionnaire of risk factor of cerebral infarction was designed to measure the following items: chronic bronchitis, hypertension, diabetes mellitus, hyperlipemia, coronary heart disease, primary cerebral infarction/transient ischemic attack and history of smoking. ② Cerebral infarction was regarded as the dependent variance, while chronic bronchitis, hypertension, diabetes mellitus, hyperiipemia, primary cerebral infarction/transient ischemic attack, coronary heart disease and smoking were regarded as the independent variance for multiple regression analysis.MAIN OUTCOME MEASURES: Risk factors of senile cerebral infarction.RESULTS: All 147 patients with acute cerebral infarction and 147 subjects without cerebrovascular diseases were involved in

  1. Bronchitis - acute

    Science.gov (United States)

    ... sharing features on this page, please enable JavaScript. Acute bronchitis is swelling and inflammation in the main passages ... present only for a short time. Causes When acute bronchitis occurs, it almost always comes after having a ...

  2. Diverging trends of chronic bronchitis and smoking habits between 1998 and 2010

    Directory of Open Access Journals (Sweden)

    Accordini Simone

    2013-02-01

    Full Text Available Abstract Background No study has been carried out on the time trend in the prevalence of chronic bronchitis (CB in recent years, despite its clinical and epidemiological relevance. We evaluated the trend in CB prevalence during the past decade among young Italian adults. Methods A screening questionnaire was mailed to general population samples of 20–44 year-old subjects in two cross-sectional surveys: the Italian Study on Asthma in Young Adults (ISAYA (1998/2000; n = 18,873, 9 centres and the screening stage of the Gene Environment Interactions in Respiratory Diseases (GEIRD study (2007/2010; n = 10,494, 7 centres. CB was defined as having cough and phlegm on most days for a minimum of 3 months a year and for at least 2 successive years. The prevalence rates and the risk ratios (RRs for the association between CB and each potential predictor were adjusted for gender, age, season of response, type of contact, cumulative response rate, and centre. Results CB prevalence was 12.5% (95% CI: 12.1-12.9% in 1998/2000 and 12.6% (95% CI: 11.7-13.7% in 2007/2010; it increased among never smokers (from 7.6 to 9.1%, p = 0.003, current light smokers ( Conclusions Despite the significant reduction in current smoking, CB prevalence did not vary among young Italian adults. The temporal pattern of CB prevalence can only be partly explained by the increase of unemployment/premature retirement, asthma and allergic rhinitis, and suggests that other factors could have played a role.

  3. Plastic bronchitis

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    Anil Kumar Singhi

    2015-01-01

    Full Text Available Plastic bronchitis, a rare but serious clinical condition, commonly seen after Fontan surgeries in children, may be a manifestation of suboptimal adaptation to the cavopulmonary circulation with unfavorable hemodynamics. They are ominous with poor prognosis. Sometimes, infection or airway reactivity may provoke cast bronchitis as a two-step insult on a vulnerable vascular bed. In such instances, aggressive management leads to longer survival. This report of cast bronchitis discusses its current understanding.

  4. Current asthma contributes as much as smoking to chronic bronchitis in middle age: a prospective population-based study

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    Dharmage SC

    2016-08-01

    Full Text Available Shyamali C Dharmage,1 Jennifer L Perret,1,2, John A Burgess,1 Caroline J Lodge,1 David P Johns,3 Paul S Thomas,4 Graham G Giles,1,5 John L Hopper,1,6 Michael J Abramson,7,8 E Haydn Walters,3,9, Melanie C Matheson1 1Allergy and Lung Health Unit, Center for Epidemiology and Biostatistics, The University of Melbourne, 2Institute for Breathing and Sleep (IBAS, Melbourne, VIC, 3“Breathe Well” Center of Research Excellence for Chronic Respiratory Disease and Lung Ageing, School of Medicine, University of Tasmania, Hobart, TAS, 4Inflammation and Infection Research, Faculty of Medicine, University of New South Wales, Sydney, NSW, 5Cancer Epidemiology Center, Cancer Council Victoria, Melbourne, VIC, Australia; 6Department of Public Health, Seoul National University, Seoul, South Korea; 7Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, 8School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 9School of Medicine, University of Tasmania, Hobart, TAS, Australia Background and objective: Personal smoking is widely regarded to be the primary cause of chronic bronchitis (CB in adults, but with limited knowledge of contributions by other factors, including current asthma. We aimed to estimate the independent and relative contributions to adult CB from other potential influences spanning childhood to middle age.Methods: The population-based Tasmanian Longitudinal Health Study cohort, people born in 1961, completed respiratory questionnaires and spirometry in 1968 (n=8,583. Thirty-seven years later, in 2004, two-thirds responded to a detailed postal survey (n=5,729, from which the presence of CB was established in middle age. A subsample (n=1,389 underwent postbronchodilator spirometry between 2006 and 2008 for the assessment of chronic airflow limitation, from which nonobstructive and obstructive CB were defined. Multivariable and multinomial logistic regression models were used to estimate

  5. Efficacy and safety of moxifloxacin in acute exacerbations of chronic bronchitis: a prospective, multicenter, observational study (AVANTI

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    Chuchalin Alexander

    2013-01-01

    Full Text Available Abstract Background Acute exacerbations of chronic bronchitis (AECB, including chronic obstructive pulmonary disease (AECOPD, represent a substantial patient burden. Few data exist on outpatient antibiotic management for AECB/AECOPD in Eastern/South Eastern Europe, in particular on the use of moxifloxacin (Avelox®, although moxifloxacin is widely approved in this region based on evidence from international clinical studies. Methods AVANTI (AVelox® in Acute Exacerbations of chroNic bronchiTIs was a prospective, observational study conducted in eight Eastern European countries in patients > 35 years with AECB/AECOPD to whom moxifloxacin was prescribed. In addition to safety and efficacy outcomes, data on risk factors and the impact of exacerbation on daily life were collected. Results In the efficacy population (N = 2536, chronic bronchitis had been prevalent for > 10 years in 31.4% of patients and 66.0% of patients had concomitant COPD. Almost half the patients had never smoked, in contrast to data from Western Europe and the USA, where only one-quarter of COPD patients are non-smokers. The mean number of exacerbations in the last 12 months was 2.7 and 26.3% of patients had been hospitalized at least once for exacerbation. Physician compliance with the recommended moxifloxacin dose (400 mg once daily was 99.6%. The mean duration of moxifloxacin therapy for the current exacerbation (Anthonisen type I or II in 83.1%; predominantly type I was 6.4 ± 1.9 days. Symptom improvement was reported after a mean of 3.4 ± 1.4 days. After 5 days, 93.2% of patients reported improvement and, in total, 93.5% of patients were symptom-free after 10 days. In the safety population (N = 2672, 57 (2.3% patients had treatment-emergent adverse events (TEAEs and 4 (0.15% had serious TEAEs; no deaths occurred. These results are in line with the known safety profile of moxifloxacin. Conclusions A significant number of patients in this

  6. Clinical efficacy of farcosolvin syrup (ambroxol–theophylline–guaiphenesin mixture in the treatment of acute exacerbation of chronic bronchitis

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    Mostafa Yakoot

    2010-07-01

    Full Text Available Mostafa Yakoot1, Amel Salem2, Abdel-Mohsen Omar31Green Clinics and Research Center, Alexandria, Egypt; 2Al-Mabarah Hospital, 3Faculty of Pharmacy, Alexandria University, Alexandria, EgyptBackground: Acute exacerbations of chronic bronchitis (AECB are defined as recurrent attacks of worsening bronchial inflammation that are marked by an increase in the volume of daily sputum produced, a change in color of the expectorated sputum, and worsening dyspnea. Farcosolvin® (Pharco Pharmaceuticals, Alexandria, Egypt is a mixture of ambroxol (15 mg; theophylline (50 mg; and guaiphenesin (30 mg, per 5 mL syrup.Objective: To test the clinical efficacy of Farcosolvin in the treatment of AECB in a randomized, single-blinded, controlled study design.Patients and methods: One hundred patients with AECB were randomized to either Farcosolvin or guaiphenesin treatment groups, in addition to the standard medical treatment for their cases. Baseline clinical symptomatolgy of breathlessness, cough, and sputum severity scoring were compared before and after 3 and 7 days of treatment in both groups and the differences compared between groups. Changes in perceived improvement were also compared between groups using the Clinical Global Impression of Improvement or Change Scale (CGIC.Results: There were statistically significant improvements in breathlessness and cough scores in both groups (pretreatment versus posttreatment at day 3 and at day 7; P < 0.05. There were highly statistically significant differences between groups in improvement in ­breathlessness and cough scores, after 3 and 7 days treatment, in favor of the Farcosolvin ­treatment group (P < 0.001. Out of 50 patients, 48 (96% in the Farcosolvin-treated group rated their ­improvement on the CGIC scale as “much” and “very much” improved, while only 41 patients (82% reported such a degree of improvement in the control group. The difference was statistically significant (P < 0.05.Conclusion: We

  7. Comparative effects of dexamethasone and bergenin on chronic bronchitis and their anti-inflammatory mechanisms based on NMR metabolomics.

    Science.gov (United States)

    Ren, Xiaolei; Ma, Shuangshuang; Wang, Juan; Tian, Simin; Fu, Xiaorui; Liu, Xinfeng; Li, Zhongfeng; Zhao, Baosheng; Wang, Xueyong

    2016-05-24

    In order to compare the effect of dexamethasone and bergenin on chronic bronchitis and to reveal their anti-inflammatory mechanisms, (1)H NMR-based metabolomics was performed to explore the potential biomarkers of the disease and study the therapeutic mechanisms of the drugs. In this study, 40 Sprague-Dawley male rats were randomly divided into 4 groups, namely control, model, dexamethasone and bergenin groups, with 10 rats in each group. Except for the control group, rats from the other three groups were exposed to tobacco smoke for 1 h d(-1) for 28 days. During the modeling, dexamethasone (0.2 mg kg(-1)) and bergenin (87 mg kg(-1)) were administered orally to dexamethasone or bergenin rats 3 h after exposure every day. On the other hand, control and model rats were intragastrically administered water. According to the results of morphometric analysis of the airway epithelium and the count of white blood cells in the bronchoalveolar lavage fluid (BALF), dexamethasone and bergenin could suppress the infiltration of inflammatory cells, inhibit the secretion of mucus, and reduce white blood cells in BALF. Serum samples from the rats' orbits were collected every week. The metabolic profiles of sera were analyzed by multivariate statistical analyses, including PCA, PLS-DA and OPLS-DA models, and 18 metabolites were identified. The dynamic fluctuations of these biomarkers in sera from different groups were detected. The results suggested that the anti-inflammatory mechanism of dexamethasone may be associated with BCAA metabolism and glycolysis while bergenin could change BCAA metabolism, glycine, serine and threonine metabolism, and glycolysis to treat chronic bronchitis. PMID:27098339

  8. Impact of exacerbations on health care cost and resource utilization in chronic obstructive pulmonary disease patients with chronic bronchitis from a predominantly Medicare population

    Directory of Open Access Journals (Sweden)

    Pasquale MK

    2012-11-01

    Full Text Available Margaret K Pasquale,1 Shawn X Sun,2 Frank Song,1 Heather J Hartnett,1 Stephen A Stemkowski11Competitive Health Analytics, Louisville, KY, USA; 2Health Economics and Outcomes Research, Forest Research Institute, Jersey City, NJ, USABackground: Exacerbations of chronic obstructive pulmonary disease (COPD lead to significant increases in resource utilization and cost to the health care system. COPD patients with chronic bronchitis and a history of exacerbations pose an additional burden to the system. This study examined health care utilization and cost among these patients.Methods: For this retrospective analysis, data were extracted from a large national health plan with a predominantly Medicare population. This study involved patients who were aged 40–89 years, had been enrolled continuously for 24 months or more, had at least two separate insurance claims for COPD with chronic bronchitis (International Classification of Diseases, Ninth Revision, Clinical Modification code 491.xx, and had pharmacy claims for COPD maintenance medications between January 1, 2007, and March 31, 2009. Two years of data were examined for each patient; the index date was defined as the first occurrence of COPD. Baseline characteristics were obtained from the first year of data, with health outcomes tracked in the second year. Severe exacerbation was defined by COPD-related hospitalization or death; moderate exacerbation was defined by oral or parenteral corticosteroid use. Adjusted numbers of exacerbations and COPD-related costs per patient were estimated controlling for demographic and clinical characteristics.Results: The final study sample involved 8554 patients; mean age was 70.1 ± 8.6 years and 49.8% of the overall population had exacerbation, 13.9% had a severe exacerbation only, 29.1% had a moderate exacerbation only, and 6.8% had both a severe and moderate exacerbation. COPD-related mean annual costs were $4069 (all figures given in US dollars for the

  9. ECOLOGICAL STRESS AND ITS EFFECTS ON ESSENTIAL HYPERTENSION AND CHRONIC OBSTRUCTIVE BRONCHITIS DEVELOPMENT IN ROSTOV-ON-DON INHABITANTS

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    L. I. Katelnitskaya

    2015-12-01

    Full Text Available Aim. To study prevalence of essential hypertension (HT and chronic obstructive bronchitis (COB among Rostov-on-Don population, to assess influence of ecological stress on HT and COB development and to find the ways to improve therapy of combined pathology.Material and methods. Single-stage epidemiologic study of Rostov-on-Don population was carried out. The study included questionnaire to reveal main risk factors of chronic noninfectious diseases, a number of laboratory and instrumental indices.Results. Prevalence of HT and COB is significantly higher in patients, living in ecologically unfavorable districts. Rigidity and stretch ability of vascular wall influence the course and development of HT as well as atrial natriuretic factor. Carbonic anhydrase inhibitor, acetazolamide, when is added to standard therapy increases in its efficacy in blood pressure control, decrease in blood pressure in pulmonary artery and correction of disturbed acidbase balance in patients with HT combined with COB.Conclusion. The connection between unfavorable ecology and HT and COB development is demonstrated. Adjuvant therapy with acetazolamide is proposed to increase in efficacy of HT and COB standard therapy.

  10. Traffic-related air pollution associated with prevalence of asthma and COPD/chronic bronchitis. A cross-sectional study in Southern Sweden

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    Nihlén Ulf

    2009-01-01

    Full Text Available Abstract Background There is growing evidence that air pollution from traffic has adverse long-term effects on chronic respiratory disease in children, but there are few studies and more inconclusive results in adults. We examined associations between residential traffic and asthma and COPD in adults in southern Sweden. A postal questionnaire in 2000 (n = 9319, 18–77 years provided disease status, and self-reported exposure to traffic. A Geographical Information System (GIS was used to link geocoded residential addresses to a Swedish road database and an emission database for NOx. Results Living within 100 m of a road with >10 cars/minute (compared with having no heavy road within this distance was associated with prevalence of asthma diagnosis (OR = 1.40, 95% CI = 1.04–1.89, and COPD diagnosis (OR = 1.64, 95%CI = 1.11–2.4, as well as asthma and chronic bronchitis symptoms. Self-reported traffic exposure was associated with asthma diagnosis and COPD diagnosis, and with asthma symptoms. Annual average NOx was associated with COPD diagnosis and symptoms of asthma and chronic bronchitis. Conclusion Living close to traffic was associated with prevalence of asthma diagnosis, COPD diagnosis, and symptoms of asthma and bronchitis. This indicates that traffic-related air pollution has both long-term and short-term effects on chronic respiratory disease in adults, even in a region with overall low levels of air pollution.

  11. [Early detection of chronic dust-induced bronchitis in the workers of coal mines in Rostov region].

    Science.gov (United States)

    Zabolotnikova, O D; Piktushanskaia, I N; Kutovoĭ, V I

    1994-01-01

    To diagnose mild forms of dust bronchitis in miners, the medical examination covered pulmonary ventilation parameters. The examination revealed bronchial obstruction, so early stages of bronchitis became 2-2.5 times more frequently diagnosed. Registration of flow-volume curve in forced expiration appeared to be the most productive functional test. PMID:7866714

  12. Cefditoren versus levofloxacin in patients with exacerbations of chronic bronchitis: serum inflammatory biomarkers, clinical efficacy, and microbiological eradication

    Directory of Open Access Journals (Sweden)

    Blasi F

    2013-02-01

    Full Text Available Francesco Blasi, Paolo Tarsia, Marco Mantero, Letizia C Morlacchi, Federico PifferDepartment of Pathophysiology and Transplantation, University of Milan, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Milan, ItalyBackground: The aim of this open-label, randomized, parallel-group pilot study was to evaluate the efficacy of cefditoren pivoxil and levofloxacin in terms of speed of reduction in inflammatory parameters, clinical recovery, and microbiological eradication.Methods: Forty eligible patients with acute exacerbation of chronic bronchitis (AECB were randomized to receive cefditoren 200 mg twice a day for 5 days (n = 20 or levofloxacin 500 mg once daily for 7 days (n = 20.Results: The inflammatory parameters which were significantly reduced at test-of-cure with respect to visit 1 were Krebs von den Lundgen-6 (KL-6 and interleukin-6. KL-6 decreased both in the overall study population (from 19 ± 11 UI/mL to 6 ± 8 UI/mL, P = 0.000 and in the cefditoren (from 19 ± 13 UI/mL to 8 ± 10 UI/mL, P = 0.006 and levofloxacin (from 19 ± 10 UI/mL to 5 ± 5 UI/mL, P = 0.000 arms. Similarly, interleukin-6 decreased both in the overall study population (from 13.35 ± 16.41 pg/mL to 3 ± 4.7 pg/mL, P = 0.000 and in the cefditoren (from 15.90 ± 19.54 pg/mL to 4.13 ± 6.42 pg/mL, P = 0.015 and levofloxacin (from 10.80 ± 12.55 pg/mL to 1.87 ± 1.16 pg/mL, P = 0.003 arms. At the end of treatment (test-of-cure, 6–9 days after drug initiation, the clinical success rate in the overall study population was 78%; the clinical cure rate was 80% in the cefditoren arm and 75% in the levofloxacin arm. Globally, bacteriological eradication at test-of-cure was obtained in 85% of the overall study population. Both treatments were well tolerated.Conclusion: Cefditoren represents a valid option in the treatment of mild to moderately severe cases of AECB in the outpatient care setting. Moreover, the use of this cephalosporin is associated with a significant

  13. Chronic obstructive pulmonary disease

    Science.gov (United States)

    ... airways disease; Chronic obstructive lung disease; Chronic bronchitis; Emphysema; Bronchitis - chronic ... a protein called alpha-1 antitrypsin can develop emphysema. Other risk factors for COPD are: Exposure to ...

  14. Aclidinium bromide inhalation powder for the long-term, maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease including chronic bronchitis and emphysema.

    Science.gov (United States)

    Matera, Maria Gabriella; Sanduzzi, Alessandro; Alfano, Roberto; Cazzola, Mario

    2016-06-01

    Aclidinium is a twice-daily long-acting muscarinic receptor antagonist (LAMA) with an interesting pharmacological profile. Recent evidence indicates that this LAMA, in addition to causing a significant improvement in lung function and other important supportive outcomes, such as health related quality of life, dyspnea and nighttime/early morning symptoms in patients suffering from COPD, is also able to significantly reduce the rate of exacerbations of any severity, is extremely effective in controlling the COPD symptoms, is able to reduce lung hyperinflation, and has an excellent cardiovascular safety profile. Consequently, aclidinium should be considered a first-line approach at least for the symptomatic treatment of COPD although there are still few head-to-head studies comparing this LAMA with other bronchodilators. In any case, aclidinium can be taken into account in the treatment of different COPD phenotypes (emphysema, chronic bronchitis, exacerbators and patients with overlap COPD asthma). PMID:26998725

  15. Ambient temperature and outpatient visits for acute exacerbation of chronic bronchitis in Shanghai: a time series analysis.

    Science.gov (United States)

    Huang, Fang; Zhao, Ang; Chen, Ren Jie; Kan, Hai Dong; Kuang, Xing Ya

    2015-01-01

    The association between ambient temperature and acute exacerbation of chronic bronchitis (AECB) was still unknown. Therefore, we performed an epidemiological study in a large hospital of Shanghai to explore the relationship about temperature and outpatient visit for AECB. We adopted a quasi-Poisson generalized additive models and distributed lag nonlinear models to estimate the accumulative effects of temperature on AECB across multiple days. We found significant non-linear effects of cold temperature on hospital visits for AECB, and the potential effect of cold temperature might last more than 2 weeks. The relative risks of extreme cold (first percentiles of temperature throughout the study period) and cold (10th percentile of temperature) temperature over lags 0-14 d were 2.98 [95% confidence intervals (CI): 1.77, 5.04] and 1.63 (95% CI: 1.21, 2.19), compared with the 25th percentile of temperature. However, we found no positive association between hospital visits and hot weather. This study showed that exposure to both extreme cold and cold temperatures were associated with increased outpatient visits for AECB in a large hospital of Shanghai. PMID:25566865

  16. Contrasting geographical distribution of mortality from pneumoconiosis and chronic bronchitis and emphysema in British coal miners.

    OpenAIRE

    Coggon, D; Inskip, H.; Winter, P; Pannett, B

    1995-01-01

    To explore whether the characteristics of coal mine dust that predispose to chronic airways obstruction are the same as those associated with pneumoconiosis, mortality from the two disease was compared in coal miners in 22 counties of England and Wales during 1979-80 and 1982-90. The proportional mortality ratios (PMRs) for coal workers' pneumoconiosis varied from 135 (95% confidence interval (95% CI) 16-488) in Leicestershire to 3825 (95% CI 1538-7881) in South Glamorgan. The PMRs for chroni...

  17. High-dose oral N-acetylcysteine fails to improve respiratory health status in patients with chronic obstructive pulmonary disease and chronic bronchitis: a randomized, placebo-controlled trial

    Directory of Open Access Journals (Sweden)

    Johnson K

    2016-04-01

    Full Text Available Kara Johnson,1,2 Charlene E McEvoy,3 Sakina Naqvi,1,4 Chris Wendt,1 Ronald A Reilkoff,4,5 Ken M Kunisaki,1 Erin E Wetherbee,1 David Nelson,6 Rabindra Tirouvanziam,7 Dennis E Niewoehner1 1Pulmonary Section, Minneapolis VA Health Care System, Minneapolis, MN, 2Sanford Health, Fargo, ND, 3Pulmonary Section, HealthPartners Research Foundation, St Paul, 4HealthEast Maplewood Clinic, Maplewood, 5Pulmonary Section, University of Minnesota Medical Center, 6Center for Chronic Disease Outcomes Research, Minneapolis VA Health Care System, Minneapolis, MN, 7Center for Cystic Fibrosis and Airways Disease Research, Emory University School of Medicine, Atlanta, GA, USA Background: Clinical outcomes are worse in patients with COPD and chronic bronchitis. N-acetylcysteine (NAC is commonly prescribed for such patients but with uncertain clinical benefits. We postulated that oral NAC, at much larger doses than those ordinarily prescribed, would improve clinical outcomes in a subset of patients with COPD and chronic bronchitis. Objective: The aim of this study was to determine whether very high-dose NAC would improve respiratory health status in patients with COPD and chronic bronchitis. Methods: Patients with COPD and chronic bronchitis were enrolled in a randomized, controlled, double-blinded trial. Patients received oral NAC (1,800 mg or matching placebo twice daily for 8 weeks in addition to their usual respiratory medications. The primary outcome, respiratory health status, was assessed by changes in the St George’s Respiratory Questionnaire. The effects of NAC on lung function and circulating markers of oxidative stress and inflammation were also evaluated. Results: We terminated the study prematurely because new external information suggested the possibility of a safety issue. Of the planned 130 patients, 51 were randomized and 45 (22 in the placebo arm and 23 in the NAC arm completed the study. There was no statistically significant difference between

  18. Otras enfermedades obstructivas: bisinosis, bronquitis crónica y EPOC de origen laboral y bronquitis eosinofílica Other obstructive diseases: byssinosis, chronic bronchitis and occupational COPD and eosinophilic bronchitis

    Directory of Open Access Journals (Sweden)

    F. J. Michel De la Rosa

    2005-01-01

    Full Text Available Además del asma ocupacional y las enfermedades derivadas de la inhalación aguda, otras enfermedades obstructivas también reconocen un origen laboral. Aunque en la actualidad la bisinosis es una enfermedad rara en España, describimos las características de la misma por su interés histórico dentro de las enfermedades respiratorias de origen laboral y porque todavía sigue vigente en los países en vías de desarrollo. La bronquitis crónica también puede estar relacionada con la exposición laboral a polvos y humos, con frecuencia denominada "bronquitis industrial". La relación ocupacional de la EPOC ha sido más controvertida a lo largo de la historia, pero en la actualidad esta relación está aceptada; describimos la evidencia actual que sustenta esta relación. En último lugar, describimos la bronquitis eosinofílica sin asma, entidad descrita por primera vez en 1989 y que en ocasiones también puede tener un origen laboral, compartiendo agentes etiológicos con el asma ocupacional.Besides occupational asthma and diseases derived from acute inhalation, other obstructive diseases also have an occupational origin. Although at present byssinosis is a rare disease in Spain, we describe its characteristics because of its historical interest amongst occupational respiratory diseases and because it is still relevant in developing countries. Chronic bronchitis can also be related to exposure at work to dust and smoke, and is often referred to as "industrial bronchitis". Historically, the relation of CPOD to occupation has been subject to controversy, but nowadays this relationship is accepted; we describe the present evidence supporting this relationship. Finally, we describe eosinophilic bronchitis without asthma, an entity that was described for the first time in 1989 and that can sometimes have an occupational origin, sharing aetiological agents with occupational asthma.

  19. 崔应珉教授治疗慢性支气管炎经验%Experience of Professor Cui Yingmin in the Treatment of Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    张珂

    2013-01-01

    Objective:To summarize the experience of Professor Cui Yingmin in the treatment of chronic bronchitis. Methods: Based on chronic bronchitis cases treated by Professor Cui Yingmin,to analyze and summarize the dialectical thought and clinical experiences. Results: Professor Cui Yingmin regarded chronic bronchitis was deficiency for the fundamental reason and excess in manifestation, with lung,spleen and kidney for the deficiency,while phlegm and blood stasis as the manifestation. Clinical treatment was acute exacerbation of chronic,with remission and delayed treatment by stage,with the modification of Shegan Mahuang soup,Yuebi Jiazhu soup,Sanzi Yan-gqin soup, Buzhong Yiqi soup, Erchen soup, Shashen Maidong soup. The clinical curative effect was marked. Conclusion: Professor Cui Yingmin argues that chronic bronchitis is an easily relapsed and refractory disease,in clinical it should be treated by stages by taking care of the fundermental causes and manifestations, which provides some clinical reference.%目的:探讨崔应珉教授治疗慢性支气管炎经验.方法:以崔应珉教授治疗慢性支气管炎验案为依据,分析总结其辨证思路及临证经验.结果:崔应珉教授针对慢性支气管炎多为本虚标实这一特点,以肺、脾、肾三脏亏虚为本,痰浊、瘀血为标,临床施治多以急性加重期、慢性缓解期与迁延期分期论治,以射干麻黄汤、越婢加术汤、三子养亲汤、补中益气汤、二陈汤、沙参麦冬汤等灵活化裁,临床疗效显著.结论:崔应珉教授认为慢性支气管炎是一种易复发难治性疾病,临床采用分期辨治,标本兼顾,可资临床参考.

  20. 135例慢性支气管炎急性发作的护理%Nursing Care of 135 Cases With Acute Exacerbation of Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    苏艳镁; 张英

    2016-01-01

    Objective To investigate the nursing methods of chronic bronchial acute attack.Methods Selected 135 patients with acute exacerbation of chronic bronchitis from January 2013 to December 2014 in our hospital, given the comprehensive nursing intervention. Results The effective rate of the treatment of patients with disease was 94.8%, and the satisfaction of nursing satisfaction was 100%.Conclusion It’s important to carry out comprehensive nursing intervention for patients with acute exacerbation of chronic bronchitis, which can effectively improve the patient's condition.%目的:对慢性支气管急性发作的护理方法予以探讨。方法随机选取我院2013年1月~2014年12月接收的慢性支气管炎急性发作期患者135例,针对患者的实际特点,积极为患者开展综合护理干预。结果患者治疗有效率达94.8%,护理满意度调查中显示,护理满意度为100%。结论积极为慢性支气管炎急性发作期患者开展综合护理干预,能够有效的改善患者的病情。

  1. 自拟咳嗽方治疗急慢性支气管炎200例疗效观察%The effect of self cough decoction in the treatment of acute,chronic bronchitis in 200 cases

    Institute of Scientific and Technical Information of China (English)

    鲜晓燕; 张鲁燕

    2014-01-01

    Objective:To observe the curative effect of self cough decoction add and subtract in the treatment of acute and chronic bronchitis.Methods:200 cases of patients with acute and chronic bronchitis were used self cough decoction add and subtract treatment.Results:The total effective rate was 100%.Conclusion:The curative effect of self cough decoction in the treatment of acute and chronic bronchitis is satisfactory.%目的:观察自拟止咳方加减治疗急慢性支气管炎的疗效。方法:对200例急慢性支气管炎患者采用自拟止咳方加减治疗。结果:总有效率100%。结论:自拟止咳方治疗急慢性支气管炎疗效满意。

  2. Diagnosing and Treating Acute Bronchitis

    Science.gov (United States)

    ... Lung Disease Lookup > Acute Bronchitis Diagnosing and Treating Acute Bronchitis It is important to get your questions about ... Symptoms that last a few weeks How Is Acute Bronchitis Diagnosed? Healthcare providers diagnose acute bronchitis by asking ...

  3. Chronic bronchitis and current smoking are associated with more goblet cells in moderate to severe COPD and smokers without airflow obstruction.

    Directory of Open Access Journals (Sweden)

    Victor Kim

    Full Text Available Goblet cell hyperplasia is a classic but variable pathologic finding in COPD. Current literature shows that smoking is a risk factor for chronic bronchitis but the relationship of these clinical features to the presence and magnitude of large airway goblet cell hyperplasia has not been well described. We hypothesized that current smokers and chronic bronchitics would have more goblet cells than nonsmokers or those without chronic bronchitis (CB, independent of airflow obstruction.We recruited 15 subjects with moderate to severe COPD, 12 healthy smokers, and 11 healthy nonsmokers. Six endobronchial mucosal biopsies per subject were obtained by bronchoscopy and stained with periodic acid Schiff-Alcian Blue. Goblet cell density (GCD was quantified as goblet cell number per millimeter of basement membrane. Mucin volume density (MVD was quantified as volume of mucin per unit area of basement membrane.Healthy smokers had a greater GCD and MVD than nonsmokers and COPD subjects. COPD subjects had a greater GCD than nonsmokers. When current smokers (healthy smokers and COPD current smokers, n = 19 were compared with all nonsmokers (nonsmoking controls and COPD ex-smokers, n = 19, current smokers had a greater GCD and MVD. When those with CB (n = 12 were compared to those without CB (n = 26, the CB group had greater GCD. This finding was also seen in those with CB in the COPD group alone. In multivariate analysis, current smoking and CB were significant predictors of GCD using demographics, lung function, and smoking pack years as covariates. All other covariates were not significant predictors of GCD or MVD.Current smoking is associated with a more goblet cell hyperplasia and number, and CB is associated with more goblet cells, independent of the presence of airflow obstruction. This provides clinical and pathologic correlation for smokers with and without COPD.

  4. How Is Bronchitis Treated?

    Science.gov (United States)

    ... symptoms and make breathing easier. If you have acute bronchitis, your doctor may recommend rest, plenty of fluids, ... treat fever. Antibiotics usually aren't prescribed for acute bronchitis. This is because they don't work against ...

  5. 慢性支气管炎的护理干预效果观察%Effect of nursing intervention on chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    贺国庆

    2014-01-01

    目的:探讨慢性支气管炎患者的护理效果。方法我院从2011年3月-2013年1月共收治慢性支气管炎患者100例,给予临床观察、心理护理、用药护理、生活护理、健康指导等,对其临床护理资料进行回顾性分析。结果在本组的100例慢性支气管炎患者中,经过治疗与护理之后,显效的患者86例,所占的比例是86%,有效的患者12例,所占的比例是12%,无效的患者2例,所占的比例是2%,总有效率是98%。在本组的患者中,住院时间最短的是7 d,最长的是23 d,平均住院时间是(13.8±4.8)d。本组患者均没有严重的并发症。结论对于慢性支气管炎患者,通过给予全方面的科学护理,有利于患者的病情早日康复,降低并发症的发生率,提高患者的生存质量。%Objective To investigate the nursing effect of patients with chronic bronchitis. Methods In our hospital from 2011 March to 2013 January were treated 100 patients with chronic bronchitis, given clinical observation, mental nursing, medication nursing, nursing, health guidance, the clinical nursing data were retrospectively analyzed. Results In 100 cases of chronic bron-chitis patients in this group, after treatment and nursing care of 86 cases of patients, effective, proportion is 86%, 12 cases were ef-fective in patients, the proportion was 12%, 2 cases of invalid patients, the proportion was 2%, the total efficiency is 98%. In this group of patients, hospitalized in the shortest period of time is 7 days, the longest is 23 days, average hospitalization time was (13.8 ± 4.8) days. The patients had no serious complications. Conclusion For the patients of chronic bronchitis, by giving the scientific com-prehensive nursing, conducive to patient recovery, reduce the incidence of complications, improve the quality of life of patients.

  6. 盐酸美西律治疗慢性支气管炎临床分析%Clinical Analysis of Mexiletine Hydrochloride Treatment for Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    赵丹

    2013-01-01

    目的:观察盐酸美西律雾化吸入治疗慢性支气管炎急性发作时的临床疗效。方法选取我院收治的56例慢性支气管炎急性发作患者,随机分两组,对照组给予常规治疗,实验组在常规治疗的基础上加盐酸美西律注射液15mg、生理盐水5ml进行雾化吸入治疗。结果对照组总有效率75%,实验组总有效率93%。结论加用盐酸美西律雾化吸入治疗有利于缩短病程,值得推广应用。%Objective To observe the clinical ef icacy of mexiletine hydrochloride inhalation in treatment of acute exacerbations of chronic bronchitis. Methods:in our hospital treated 56 cases of acute exacerbations of chronic bronchitis, were randomly divided into two groups, the control group was given conventional treatment, the experimental group on the basis of conventional therapy plus mexiletine hydrochloride injection 15mg, saline inhalation of 5ml treatment. Results:the total ef ective rate of the control group 75%, the experimental group, the total ef iciency of 93%. Conclusion: combined with mexiletine hydrochloride inhalation therapy can shorten the course of disease, it is worthy of popularization and application.

  7. 溴己新治疗慢性支气管炎的疗效评价%Curative effect evaluation of bromhexine for the treatment of chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    邓梓辛; 张美祥; 谭璐; 汪曲; 王树平

    2015-01-01

    Objective To assess the effect and safety of bromhexine for chronic bronchitis .Methods We retrieve the database inclu‐ding PubMed ,the Cochrane library ,China National Knowledge Internet (CNKI) ,Weip Database (VIP) and Wanfang Data . Eight randomized controlled trials (RCT ) comparing bromhexine with ambroxol ,Erchentang ,Kechuanning oral liquid ,S‐carboxy‐methylcysteine and placebo were included in this research .The course of treatment was more than 5 days .The Jadad quality tools was used for the quality evaluation of each study .Results There were 4 RCTs which compared bromhexine with ambroxol ,with significant difference in clinical overall efficacy [RR=0 .83 ,95% CI(0 .76 ,0 .91) ,P<0 .000 1] .The rest groups required descrip‐tive analysis for study quantity .Conclusion Chronic bronchitis can be treated effectively by bromhexine .However ,compared with ambroxol ,the result of quality grade and Meta‐analysis reveals lower curative effect .%目的:评价溴己新治疗慢性支气管炎的疗效及安全性。方法通过检索PubMed、Cochrane library、中国期刊全文数据库(China National Knowledge Internet ,CNKI)、维普数据库(Weip Database ,VIP)和万方数字化期刊全文数据库;纳入随机对照试验(Randomized Controlled Trial ,RCT)8篇,包括溴己新对比氨溴索、二陈汤、咳喘宁口服液、S‐羧甲半胱氨酸和安慰剂组;利用Jadad质量评分工具进行方法质量评价。结果溴己新组对比氨溴索组共4个RC T ,临床总有效率比较:R R=0.83,95% C I (0.76,0.91),P<0.0001,差异有统计学意义。其余组由于文献数量少限制而进行描述性分析。结论溴己新可以有效地治疗慢性支气管炎,但是质量评分以及Meta分析显示其疗效低于氨溴索。

  8. Gemifloxacin for the treatment of community-acquired pneumonia and acute exacerbation of chronic bronchitis: a meta-analysis of randomized controlled trials

    Institute of Scientific and Technical Information of China (English)

    ZHANG Lei; WANG Rui; Falagas E. Matthew; CHEN Liang-an; LIU You-ning

    2012-01-01

    Background Gemifloxacin is a fluoroquinolone antibiotic with broad spectrum of antibacterial activity.The aim of the study was to evaluate the comparative effectiveness and safety of gemifloxacin for the treatment of patients with community-acquired pneumonia (CAP) or acute exacerbation of chronic bronchitis (AECB).Methods We performed a meta-analysis of randomized controlled trials (RCTs) comparing gemifloxacin with other approved antibiotics.The PubMed,EMBASE,Chinese Biomedical Literature Database and the Cochrane Central Register of Controlled Trials were searched,with no language restrictions.Results Ten RCTs,comparing gemifloxacin with other quinolones (in 5 RCTs) and β-lactams and/or macrolides (in 5 RCTs),involving 3940 patients,were included in this meta-analysis.Overall,the treatment success was higher for gemifloxacin when compared with other antibiotics (odds ratio 1.39,95% confidence interval 1.15-1.68 in intention-to-treat patients,and 1.33,1.02-1.73 in clinically evaluable patients).There was no significant difference between the compared antibiotics regarding microbiological success (1.19,0.84-1.68) or all-cause mortality (0.82,0.41-1.63).The total drug related adverse events were similar for gemifloxacin when compared with other quinolones (0.89,0.56-1.41),while lower when compared with β-lactams and/or macrolides (0.71,0.57-0.89).In subgroup analyses,administration of gemifloxacin was associated with fewer cases of diarrhoea and more rashes compared with other antibiotics (0.66,0.48-0.91,and 2.36,1.18-4.74,respectively).Conclusions The available evidence suggests that gemifloxacin 320 mg oral daily is equivalent or superior to other approved antibiotics in effectiveness and safety for CAP and AECB.The development of rash represents potential limitation of gemifloxacin.

  9. Clinical Observation on Qingfei Huatan Granula in Treating 129 Acute Tracheal Bronchitis or Chronic Bronchitis Patients%“清肺化痰颗粒”治疗急性气管—支气管炎及慢性支气管炎急性发作129例临床观察

    Institute of Scientific and Technical Information of China (English)

    张前进; 吕凤霞; 王华; 王丽勤

    2011-01-01

    [Objective] The aim of this study is to investigate the effects of Qingfei Huatan Granula on the 129 patients suffering from acute tracheal bronchitis or chronic bronchitis. [Methods] 129 patients were divided randomly into treatment group and control group. Qingfei Huatan Granula was given to the patients of treatment group. LingYang QingFei Pills was given to the patients of control group. Therapeutic evaluation was based on recovery of a cough and sputum. [Results] The curative effect of Qingfei Huatan Granula on the acute stage of chronic bronchitis showed that the clinical total effective rate was 84.4%,the rate of cough 87.5% and the rate of sputum 89.1%. The curative effect of LingYang QingFei Pills on the acute stage of chronic bronchitis showed that the clinical total effective rate was 81.6%,of cough 81.6% and of sputum 78.9%. The curative effect on sputum in the trial group was more significant. The curative effect of Qingfei Huatan Granula on acute tracheobronchitis showed that the clinical total effective rate was 89.2% , of cough and sputum 89.2%. The curative effect of LingYang QingFei Pills on acute tracheobronchitis showed that the clinical total effective rate was 84.4% , the rate of cough 84.4% and the rate of sputum 81.3%. The curative effect on comprehensive therapeutic efficacy and sputum in the trial group was more significant. [Conclusions] The curative effect of Qingfei Huatan Granula was better than that of LingYang QingFei Pills in comprehensive therapeutic efficacy and relief of cough and sputum of two diseases. The curative effect on comprehensive therapeutic efficacy and sputum of acute tracheobronchitis and on sputum of the acute stage of chronic bronchitis in the trial group was significant.%[目的]观察“清肺化痰颗粒”对急性气管—支气管炎及慢性支气管炎急性发作的疗效.[方法]将199例观察对象随机分为两组,治疗组129例给予“清肺化痰颗粒”,3次/d,每次1袋,1周为1个疗程;对

  10. Analysis the Clinical Value of Ambroxol Hydrochloride in Acute Exacerbation of Chronic Bronchitis%盐酸氨溴索在慢性支气管炎急性加重期的临床价值分析

    Institute of Scientific and Technical Information of China (English)

    张美艳

    2015-01-01

    Objective To investigate the application value of ambroxol hydrochloride in acute exacerbation of chronic bronchitis.Methods84 cases of chronic bronchitis in acute exacerbation stage were divided into study group (conventional therapy plus ambroxol hydrochloride) and control group (conventional therapy),according to with the hospitalization sequence.Results The total effective rate of the study group was significantly higher than that of the control group, the two group had significant difference (P<0.05); The incidence of adverse reaction in the study group was significantly lower than that in the control group (P<0.05).Conclusion Ambroxol in chronic bronchitis acute exacerbation has a high application value.%目的:探讨盐酸氨溴索在慢性支气管炎急性加重期的应用价值。方法将84例慢性支气管炎急性加重期患者按照住院先后顺序分为研究组(常规治疗+盐酸氨溴索)与对照组(常规治疗)。结果研究组患者治疗总有效率明显高于对照组,二者有显著性差异(P<0.05);研究组不良反应发生率明显低于对照组(P<0.05)。结论盐酸氨溴索在慢性支气管炎急性加重期有着较高的应用价值。

  11. The Clinical Observation of Hormone in Treatment of Acute Phase of Chronic Bronchitis%激素治疗慢性支气管炎急性期临床观察

    Institute of Scientific and Technical Information of China (English)

    蔡朝敏; 汪传臻

    2013-01-01

      目的:观察激素短疗程治疗慢性支气管炎急性期临床疗效。方法:将93例慢性支气管炎急性发作期患者随机分为治疗组48例,对照组45例,对照组予常规抗感染、解痉平喘、吸氧等对症及支持治疗,治疗组在对照组治疗基础上短期加用激素治疗,观察临床疗效。结果:治疗组临床疗效明显高于对照组。结论:激素短程治疗慢性支气管炎急性期疗效显著,可作为首选治疗。%Objective:To observe the clinical effect of short course of glucocorticoid in treatment of acute phase of chronic bronchitis.Methods:93 cases of patients with acute phase of chronic bronchitis were randomly divided into a treatment group of 48 cases,45 cases in the control group,the control group received routine anti-infection,spasmolysis,oxygen and other symptomatic and supportive treatment,the treatment group on the basis of the control group treated with short-term hormone therapy,the clinical effect was observed.Results:The clinical effect of treatment group was significantly higher than the control group. Conclusion:The effect of short-term hormone in treatment of chronic bronchitis in acute phase is good,it can be used as the preferred treatment.

  12. An effective analysis of acupoint sticking therapy on prevention of acute chronic bronchitis%穴位贴敷疗法在慢性支气管炎急性发作预防中的疗效分析

    Institute of Scientific and Technical Information of China (English)

    李健瑜; 陈文杰

    2012-01-01

      Objective: To application of acupoint sticking therapy for prevention of chronic bronchitis patients with symptoms of acute clinical effect analysis. Methods: Selected 78 cases suffering from chronic bronchitis patients case, will be divided into control group and treatment group, 39 cases in each group the average. Patients in the control group using conventional antibiotic therapy; patients in the treatment group routine antibiotic therapy combined with acupoint sticking therapy. Results: The treatment group of patients with symptoms of chronic bronchitis curative effect obviously surpasses the comparison group; treatment after a period of illness acute seizures were fewer than those in control group. Conclusion: The application of acupoint sticking therapy for prevention of chronic bronchitis patients with symptoms of acute onset of clinical effect is very obvious.%  目的:对应用穴位贴敷疗法预防慢性支气管炎患者症状急性发作的临床效果进行研究分析。方法:抽取78例患有慢性支气管炎的患者病例,将其分为对照组和治疗组,平均每组39例。对照组患者采用常规抗生素治疗;治疗组患者在常规抗生素治疗基础上加用穴位贴敷疗法进行治疗。结果:治疗组患者慢性支气管炎症状治疗效果明显优于对照组;治疗后一段时间内病情急性发作人数明显少于对照组。结论:应用穴位贴敷疗法预防慢性支气管炎患者症状急性发作的临床效果非常明显。

  13. Educating patients suffering from re-acutisation of chronic bronchitis. A pilot support project within Intermediate Care

    Directory of Open Access Journals (Sweden)

    Giulio Cocco

    2006-06-01

    Full Text Available

    Background: Chronic Obstructive Pulmonary Disease (COPD represents one of the main causes of hospitalization, disability and mortality worldwide; it is predicted that by the year 2020 it will become the third leading cause of death and the fifth leading cause of disability in industrialized countries. An educational programme has been proposed to allow the COPD patient to prevent or to deal with a reacutisation.

    Methods: The project involved 50 patients with a diagnosis of moderate or severe COPD. The education program included information relating to disease process, proper use of medication, energy conservation methods, and the filling in of the Saint George’s Respiratory Questionnaire (SGRQ, the Zung Self-Rating Depression Scale (ZSDS and the State Trait Anxiety Inventory (STAI. Sociodemographic factors, assessment of living arrangements, social and family conditions were also collected. One year later the same questionnaires and learning assessment tests were re-administered.

    Results: The mean age of the participants was 69.7±10.4 years with a mean low income and a limited degree of education. Following the educational program, an improvement of quality of life emerged consequent to the awareness of all of the forms of support provided for the pathology and socio-economic conditions. The ability to manage their therapy and their activities of daily living have improved. The mean total score on SGRQ was 78.07±7.2 pre-program and 73.12±7.2 post-program; 52% of the patients are now within normal parameters compared to the initial 30% suffering from depression syndrome, furthermore the mean anxiety value decreased from 59.54 ± 8.6 to 54.54±7.8. The number of hospital admissions and the number of smokers were also halved.

    Conclusion: The improvements obtained after conducting all of the educational sessions are significant. The high value of the mean

  14. Causes of acute bronchitis (image)

    Science.gov (United States)

    ... the respiratory system that leads into the lungs. Acute bronchitis has a sudden onset and usually appears after ... and the production of thick yellow mucus. If acute bronchitis occurs because of a bacterial infection antibiotics are ...

  15. Analysis of Influence the Prognosis of Elderly Patients with Chronic Asthmatic Bronchitis%影响老年慢性喘息性支气管炎的预后分析

    Institute of Scientific and Technical Information of China (English)

    侯金霞

    2014-01-01

    目的:探究老年慢性喘息性支气管炎接受治疗后影响其恢复的主要因素,指导后期的预防。方法选取2009年2月至2011年7月在我院接受治疗的74例慢性喘息性支气管炎老年患者用顺尔宁进行治疗,将74例患者随机分为试验组和对照组各37例。对照组采用顺尔宁联合抗生素治疗支气管炎,试验组在对照组的基础上用糖皮质激素进行平喘,解痉治疗。结果试验组:治疗总有效率为86.48%,对照组中,治疗总有效率为63.55%。结论使用糖皮质激素对患者的体征和易感染的体质有较好的作用,慢性喘息性支气管炎治疗后的预后不仅与患者的接受治疗过程中的状态有关系(P<0.05),还取决于医师总体的综合治疗措施与及时合理的程度。%Objective The main factors affecting its recovery objective inquiry of elderly patients with chronic asthmatic bronchitis after treatment, prevention guidance later. Methods We selected 74 elderly patients with chronic asthmatic bronchitis in 2009 February to 2011 July in our hospital were treated with singulair, 74 patients were randomly divided into experimental group and control group with 37 cases in each. Control group use Singulair combined with antibiotics in the treatment of bronchitis, asthma group of glucocorticoid on the basis of the control group, antispasmodic treatment. Results The total effective rate was 86.48%, the control group, the total efficiency of treatment was 63.55%. Conclusion Glucocorticoid use to good effect in patients with signs and susceptible constitution, treatment and prognosis of chronic asthmatic bronchitis not only after the patient received treatment in the process of state relations(P<0.05), comprehensive treatment also depends on the degree of doctor overall and timely and reasonable.

  16. 中医整体辨证护理干预慢性支气管炎效果观察%TCM Holistic Nursing Intervention for Chronic Bronchitis Syndrome Efficacy

    Institute of Scientific and Technical Information of China (English)

    朱东华; 胡志伟; 朱金星; 范春玲

    2015-01-01

    Objective Explore the application of traditional Chinese medicine overal dialectical nursing intervention curative ef ect and mechanism of chronic bronchitis. Methods By treating winter disease in summer,physiotherapy,acupuncture,health lifestyle guide TCM holistic nursing measures. Results Enhance the patient's physique,improve respiratory function,reducing the need for hospitalization. Conclusion Application of traditional Chinese medicine nursing skil s intervention chronic bronchitis,improve the body's resistance to disease and avoid side ef ects of antibiotics,and promote early recovery of patients.%目的:探讨应用中医整体辨证护理干预慢性支气管炎的疗效和机制。方法采用冬病夏治、理疗、针灸、健康生活方式指导等中医整体护理措施。结果增强了患者的体质,改善了呼吸功能,住院的需求也减少了。结论中医护理技术干预慢性支气管炎中的应用,提高机体的抗病能力,避免抗生素的副作用,促进患者早日康复。

  17. Greatest International ANtiinfective Trial (GIANT with moxifloxacin in the treatment of acute exacerbation of  chronic bronchitis: subanalysis of Chinese data of a global, multicenter, noninterventional study

    Directory of Open Access Journals (Sweden)

    Yulin Feng

    2010-03-01

    Full Text Available Yulin Feng1, Faguang Jin2, Shuang Mu3, Hong Shen4, Xiaohong Yang5, Yuling Wang6, Zhenshan Wang7, Yingjun Kong8, Zuke Xiao9, Qiming Feng101Respiratory Department, West China Hospital, Sichuan University, China; 2Respiratory Department, Tang Du Hospital, China; 3Respiratory Department, Peking University People’s Hospital, China; 4Emergency Department, The General Hospital of the People’s Liberation Army, China; 5Respiratory Department, Xinjiang People’s Hospital, China; 6Respiratory Department, Shi Jiazhuang First Hospital, China; 7Respiratory Department, The Second Affiliated Hospital of Dalian Medical University, China; 8Respiratory Department, The First Clinical College of Harbin Medical University, China; 9Respiratory Department, The Jiangxi Provincial People’s Hospital, China; 10Emergency Department, Shanghai Sixth People’s Hospital, ChinaBackground and objective: A single infective acute exacerbation of chronic bronchitis (AECB has a sustained effect on health status. Although a number of clinical investigations have demonstrated the efficacy of antibiotics in AECB, increased bacterial resistance has caused concern about the efficacy of currently available antibiotic therapies. This subanalysis of a global noninterventional study aimed to evaluate the impact of AECB on the patient and the community and the effectiveness and safety of a treatment with moxifloxacin (MXF tablets in daily life clinical practice in China.Methods: This prospective, noninterventional, noncontrolled, multicenter observational study, which started in China in April 2004 and ended in February 2007, was part of the global GIANT study. Patients with a diagnosis of mild to severe AECB were treated with MXF tablets 400 mg for a period at the physician’s discretion. The observation period for each patient covered a complete treatment period with MXF. For each patient, the physician documented data at an initial visit (baseline and at least one follow-up visit

  18. Dyspnea and Wheezing after Adenosine Injection in a Patient with Eosinophilic Bronchitis

    Directory of Open Access Journals (Sweden)

    Rodrigo Cartin-Ceba

    2009-01-01

    Full Text Available A 58-year-old nonsmoker female was referred for evaluation of chronic cough of 13 months duration. After an initial work-up, the patient was diagnosed to have chronic cough due to eosinophilic bronchitis. The diagnostic work-up for eosinophilic bronchitis and bronchial biopsy is discussed. Eosinophilic bronchitis is differentiated from asthma. In addition, the patient developed dyspnea, flushing, and wheezing after the administration of adenosine during a cardiac stress test in spite of a negative methacholine challenge. This indirect stimulus of airway hyperresponsiveness suggests the possible involvement of mast cells in eosinophilic bronchitis.

  19. 穴位贴敷配合中药内服治疗慢性支气管炎疗效观察%Curative Effect Observation of Acupoint Sticking Therapy Combined Orally Traditional Chinese Medicine on Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    黎沛环; 吴锡强; 赵晓燕; 宋黎梅; 王冬云

    2015-01-01

    Objective :To observe the curative effect of the treatment of acupoint application combined with orally traditional Chinese medicine on chronic bronchitis. Methods: Selected 60 cases with chronic bronchitis were divided into control group and treatment group randomly ,30 cases in each group the average. The patients in the control group received acupoint application for 6 times a year in the dog days of summer ,the third nine period after the winter solstice in 3 years in a row. And the ones in the treatment group received acupoint application combined with orally traditional Chinese medicine. Results:The recovery rate and total effective rate were higher in treatment group than those in control group. There was a significant difference between the two groups in their therapeutic effect (P<0.05),and curative effect had a tendency to improve with the increase of number of acupoint sticking therapy and orally traditional Chinese medicine. Conclusion: The treatment of acupoint application com-bined with orally traditional Chinese medicine has good and reliable effect on the prevention and cure of chronic bronchitis.%目的:观察穴位贴敷配合中药内服治疗慢性支气管炎的疗效。方法:选取60例患有慢性支气管炎的患者为研究对象,随机分为对照组和观察组,每组30例。对照组在每年三伏、三九天予以穴位贴敷治疗6次,连续3年;观察组在穴位贴敷基础上给予中药内服治疗。结果:观察组临床治愈率及总有效率均高于对照组,两组疗效比较差异显著(P<0.05),并且随穴位贴敷及内服中药次数的增加,疗效有提高的趋势。结论:穴位贴敷配合中药内服对防治慢性支气管炎有良好的作用。

  20. 慢性支气管炎急性发作患者痰病原学及耐药性分析%Sputum pathogens and drug resistance analysis of patients with acute exacerbations of chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    高成兵; 杨伟; 汪平; 幸仕洪; 王珏

    2013-01-01

    Objective Study on acute exacerbation of chronic bronchitis patients and drug resistance of pathogenic data. Methods Respiratory department of our hospital from 2010 January to 2010 December, 623 cases of acute exacerbation of chronic bronchitis treated with routine of sputum pathogenic detection. All experimental strains were API system for bacterial identification , using the disc diffusion method, according to the CLS1 drug sensitive test of antibacterial drug grouping principle. Results Qualified sputum samples were isolated from the strain of 448 strains of Gram-negative bacteria, which accounted for the main, Pseudomonas most 18. 4%. The detection of ESBL enzyme-producing strains of 13 strains of,mainly produced by a Pseudomonassp; MRSA enzyme-producing strain 5, all produced by staphylococcus; Multiple drug resistance of Acinetobacter strains of 8, mainly produced by Bauman acinetobacter. Conclusion Patients with acute exacerbations of chronic bronchitis pathogens in Gram-negative bacteria accounted for a major. The situation is more serious and resistance, clinicians should pay more attention.%目的 研究慢性支气管炎急性发作患者的病原学资料及耐药情况.方法 我院自2010年1月~2010年12月收治623例慢性支气管炎急性发作的患者,常规开展痰液病原学检测,所有实验菌株均以API系统进行细菌鉴定,采用纸片扩散法,按CLSI药敏试验抗菌药物分组原则进行.结果 合格痰液标本共分离出菌株448株,其中革兰氏阴性菌占主要,假单胞菌最多,达18.4%.其中,检出产ESBL酶菌株13株,主要由假单胞菌产生;产MRSA酶5株,全部由葡萄球菌产生;多重耐药不动杆菌8株,主要由鲍曼不动杆菌产生.结论 慢性支气管炎急性发作患者病原菌中革兰氏阴性菌占主要,且耐药情况较为严重,应引起临床高度重视.

  1. Clinical Analysis of ShuLiyi to Treat Chronic Bronchitis Acute Onset%舒利迭治疗慢性支气管炎急性发作的临床分析

    Institute of Scientific and Technical Information of China (English)

    徐亦农

    2013-01-01

    Objective:To investigate the ShuLi idea for treatment of chronic bronchitis acute episodes. Methods:A retrospective analysis from January 2010 to March 2010 were treated 140 cases of patients with chronic bronchitis acute clinical cases, according to random method the 140 patients were divided into treatment group and control group, 70 cases in each group, the treatment group patients on the basis of conventional treatment combined with ShuLi overlapping (salmeterol assigned powder inhalant), control group patients only routine phlegm treatment, compared two groups of patients in the therapeutic effect and adverse reactions. Results:The treatment group patients clinical treatment effect is better than that of control group (P<0.05), statistically significant difference between the two groups of patients. Conclusion:ShuLi overlapping (salmeterol assigned powder inhalant) can be effective for the treatment of chronic bronchitis acute episodes, good safety, small adverse reactions, worthy of popularization and application in clinic.%目的:探讨舒利迭治疗慢性支气管炎急性发作的临床效果。方法:回顾性分析我院2010年1月~2013年3月收治的140例慢性支气管炎急性发作患者的临床病例,按照随机的方法将这140例患者分为治疗组及对照组,每组70例,治疗组患者在常规治疗的基础上加用舒利迭(沙美特罗替卡松粉吸入剂),对照组患者仅行常规化痰治疗,比较两组患者的治疗效果及不良反应。结果:治疗组患者的临床治疗效果优于对照组(P<0.05),两组患者间差异具有统计学意义。结论:舒利迭(沙美特罗替卡松粉吸入剂)可有效的治疗慢性支气管炎急性发作,安全性好,不良反应小,值得在临床上推广应用。

  2. Clinical Observation of Yinqiao Zhisou Powder in Treating Acute Onset of Chronic Bronchitis%银翘止嗽散治疗慢性支气管炎急性发作期临床观察

    Institute of Scientific and Technical Information of China (English)

    汤宏涛

    2012-01-01

    Objective:To observe the clinical efficacy of Yinqiao Zhisou Powder in treating acute onset of chronic bronchitis. Methods;80 cases who were diagnosed as acute onset of chronic bronchitis were given Yinqiao Zhisou Powder ( Composition; honeysuckle 30 g, for-sythia 20 g,the Aster 15 g,Radix Stemonae 15 g,radix cynanchi 10 g,Coltsfoot 10 g,radix scutellariae 10 g,prepared Ephedra 10 g,the Campanulaceae 15 g,licorice 5 g) for treatment with water decoction,one dose per day and 10 d for a course of treatment. All cases were treated for one to two courses. Results;37 cases were cured;28 cases were markedly effective;13 cases were effective;2 cases were ineffective. The effective rate was 97.5%. Conclusion: Yinqiao Zhisou Powder has significant effect in treating acute onset of chronic bronchitis.%目的:观察自拟银翘止嗽散治疗慢性支气管炎急性发作期的临床疗效.方法:80例确诊病例采用银翘止嗽散(方药组成:金银花30 g,连翘20 g,紫菀15 g,百部15 g,白前10 g,款冬花10 g,黄芩10 g,炙麻黄10 g,桔梗15 g,甘草5 g)治疗,水煎服,日1剂,10 d为1个疗程,全部病例治疗1~2个疗程.结果:治愈37例,显效28例,有效13例,无效2例,有效率为97.5%.结论:银翘止嗽散治疗慢性支气管炎急性发作疗效显著.

  3. 多索茶碱联合氨溴索治疗慢支急性发作的疗效观察%To Observe the Curative Effect of Doxofylline Combined With Ambroxol on Acute Attack of Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    矫维荣

    2015-01-01

    目的:探讨多索茶碱联合氨溴索治疗慢性支气管炎急性发作的临床疗效。方法入选我院2013年1月~2014年1月慢性支气管炎急性发作的患者80例,随机分为两组,观察组和对照组各40例,观察组给予多索茶碱联合氨溴索治疗,对照组单纯给予氨溴索治疗,观察两组的临床效果。结果治疗后,观察组与对照组相比,咳嗽、痰液消失的时间、干湿性啰音消失的时间,P<0.05,差异具有统计学意义。两组患者治疗的总有效率比较,观察组高于对照组,P<0.05,差异具有统计学意义。结论多索茶碱与氨溴索联合治疗慢性支气管炎急性发作效果显著,安全性高,不良反应少。%Objective To investigate the clinical effect of doxofylline combined with ambroxol treatment of acute attack of chronic bronchitis. Methods Selected 80 patients with acute attack of chronic bronchitis patients in our hospital, the observation group was given doxofylline combined with ambroxol treatment, the control group only received ambroxol treatment, to observe the clinical effects of two groups.Results Cough, sputum, dry time of the disappearance of rales disappear time signiifcantly statistical difference, total effective rate of observation group is obviously higher than that in control group. Conclusion Doxofylline combined with ambroxol treatment of acute exacerbation of chronic bronchitis the effect signiifcantly.

  4. 中西医结合治疗慢性支气管炎急性发作的临床分析%Clinical Analysis of Integrated Medicine in the Treatment of Acute Exacerbation of Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    王守振

    2015-01-01

    Objective Discussing method and clinical effect of integrated medicine in the treatment of acute exacerbation of chronic bronchitis, and summarizing experience to improve treatment level of oneself .Method 140 case of patients with acute exacerbation of chronic bronchitis in our department from May 2012 to May 2014 were randomly divided into control group and observation group .The control group was given Weston medicine .On the basis of the control group , the observation received Xiaoqinglong decoction additionally .The treatment result was recorded and statistically analyzed .Result The total effective rate of the observation group and the control group was 85.71%and 98.57%, respectively , and the difference was statistically significant ( P <0.05 ) .Conclusion The clinical effect of integrated medicine in the treatment of acute exacerbation of chronic bronchitis was superior to the individual effect of the Weston medicine , and was worthy of clinical further research and promotion .%目的:探讨中西医结合治疗慢性支气管炎急性发作的方法及其临床疗效,总结经验以提高自身治疗水平。方法将2012年5月—2014年5月我科收治的140例慢性支气管炎急性发作患者随机分成对照组和观察组,对照组给予单纯西医治疗,观察组在对照组基础上加用小青龙汤加减治疗,记录两组患者治疗结果并进行统计学分析。结果对照组、观察组的总有效率分别是85.71%、98.57%,二者差异具有统计学意义(P<0.05)。结论中西医结合治疗慢性支气管炎急性发作的临床疗效明显优于单纯西医治疗,值得在临床上进一步研究,加强推广。

  5. 对小儿急慢性支气管炎患儿进行特殊护理的临床研究%Clinical study of special nursing for children with acute and chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    齐金华

    2015-01-01

    AIM: To investigate the clinical effect of special nursing for children with acute or chronic bronchitis. METH⁃ODS: A total of 78 children with acute or chronic bronchitis admitted to our hospital from April 2014 to March 2015 were selected and divided into two groups based on the nursing method, with 39 cases in each group. RESULTS: The cure rate of the observation group was significantly higher than that of the control group (P<0.05), and the nursing satisfaction was significantly higher than that of the control group ( P<0. 05 ) . CONCLU⁃SION:To imply special nursing for children with acute or chronic bronchitis can increase the cure rate, improve the nursing satisfaction, and reduce the incidence of complications.%目的:探讨对小儿急慢性支气管炎患儿进行特殊护理的临床效果.方法:选取2014-04/2015-03我院收治的小儿急慢性支气管炎患儿78例,按照护理方法分成观察组( n=39)和对照组( n=39).观察组采用特殊护理,对照组采用常规护理,观察比较两组治愈率、护理满意度和并发症发生率.结果:观察组患儿治愈率明显高于对照组(P<0.05),护理满意度明显高于对照组(P<0.05),并发症发生率明显低于对照组( P<0.05).结论:对小儿急慢性支气管炎患儿进行特殊护理,能够提高患儿治愈率,提高护理满意度,降低并发症发生率.

  6. Analysis of the effect of ambroxol hydrochloride in the treatment of acute exacerbation of chronic bronchitis%盐酸氨溴索治疗慢性支气管炎急性发作的疗效分析

    Institute of Scientific and Technical Information of China (English)

    丁宁

    2014-01-01

    目的:观察盐酸氨溴索对慢性支气管炎急性发作的临床疗效。方法:选取2012年11月-2014年3月慢性支气管炎急性发作患者60例,随机分为对照组30例和试验组30例。对照组给予吸氧、抗感染、解痉平喘等常规治疗;试验组在常规治疗基础上加用盐酸氨溴索静脉滴注,每次30 mg,每日2次,5 d为1个疗程,共2个疗程,治疗结束后比较两组疗效。结果:试验组的总有效率为96.75%,对照组为76.7%,组间差异有统计学意义(P<0.05)。结论:盐酸氨溴索治疗慢性支气管炎急性发作有较好的临床疗效。%Objective:To observe the clinical effect of ambroxol hydrochloride in the treatment of acute exacerbation of chronic bronchitis. Methods: Sixty cases with acute exacerbation of chronic bronchitis were selected from Nov. 2012 to March 2014 and divided into a control group with 30 patients and an experiment group with 30 patients at the random. The control group was treated with oxygen inhalation, anti-infection, antispasmodic and the conventional therapy. The experiment group was added with ambroxol hydrochloride injection of 30 mg every time, twice a day, 5 days a course for 2 courses based on the conventional therapy. The treatment effects of two groups were compared after the treatment. Results:The total efifcacy was 96.7% in the experiment group, and 76.7% in the control group. The difference of the two groups had the statistical signiifcance (P<0.05). Conclusion:Ambroxol hydrochloride has a good clinical effect in the treatment of acute exacerbation of chronic bronchitis.

  7. 盐酸氨溴索用于慢性支气管炎急性加重期的疗效%Efficacy of ambroxol hydrochloride on acute anabasis of chronic bronchitis patients

    Institute of Scientific and Technical Information of China (English)

    张鑫

    2012-01-01

    目的 观察盐酸氨溴索辅助治疗慢性支气管炎急性加重期患者的气道净化疗效.方法 选择2009年10月-2011年10月在我科治疗的慢支急性发作患者80例,随机分成治疗组和对照组,各40例,治疗组给予抗生素+盐酸氨溴索30 mg,2次/d静点,对照组单纯使用抗生素,两组基础治疗相同,比较两组治疗后临床症状、体征、实验室检查恢复情况.结果 治疗组总有效率为97.5%,对照组为85%,两组比较,差异有统计学意义(P<0.01).结论 盐酸氨溴索静脉用药辅助治疗慢支急性发作可明显化痰、祛痰,改善呼吸,缩短病程,且药物不良反应小.%Objective To observe the airway purification effect of ambroxol hydrochloride in acute anabasis of chronic bronchitis patients. Methods 80 patients with acute attack of chronic bronchitis who cured in our department from October 2009 to October 2011 were selected. The patients were randomly divided into treatment group and control group with 40 cases in each group. Treatment group was given antibiotics + hydrochloride ammonia bromide cable 30 mg ductus venosus twice a day; Control group was only given antibiotics. The basic treatment of the two groups was the same. The clinical symptoms, signs, and laboratory check recovery situation of the two groups after treatment were compared. Results The total effective rate of treatment group and control group were 97. 5% and 85% respectively (P < 0. 01). Conclusion Ambroxol hydrochloride has good effect on the patients with acute exacerbation of chronic bronchitis by clearing phlegm,expectorant,improving breathing,shortening the course with few side effect.

  8. The clinical analysis of 32 cases of chronic bronchitis acute attacking by MRSA infection%MRSA 感染致慢性支气管炎急性发作32例临床分析

    Institute of Scientific and Technical Information of China (English)

    高成兵

    2013-01-01

    Objective: To analyze the clinical effect of treating chronic bronchitis acute at acking by MRSA infection. Methods: Choosed 32 cases of chronic bronchitis acute at acking by MRSA infection from Dec. 2010 to Dec. 2012 to sputum culture experiment and drug sensitive test and treat with vancomycin. Results: The antibiotic susceptible rate of MRSA was 100.0%, the effective rate of study group was 93.8%, adverse rate was 6.2%. Conclusion: There is high rate in primary hospital of chronic bronchitis acute at acking by MRSA infection, but MRSA is sensitive to vancomycin.%目的:分析 MRSA(耐甲氧西林金黄色葡萄球菌)感染所致慢性支气管炎急性发作期相关情况。方法:回顾性分析2010年12月-2012年12月大邑县人民医院呼吸科住院的慢性支气管炎急性发作期的 MRSA 感染患者32例,均行痰培养实验和药敏试验,并均采用万古霉素治疗,统计药敏试验结果和临床治疗情况。结果:MRSA 对万古霉素的敏感率达100.0%;治疗总有效率93.8%,不良反应率为6.2%,临床效果比较显著。结论:基层医院中社区获得性感染致慢性支气管炎的急性发作患者中也存在较高比率的 MRSA 感染;MRSA 对万古霉素敏感,尚未发现有耐药株。

  9. Research PM2.5 concentration on acute onset of chronic bronchitis%PM2.5浓度对老年慢性支气管炎急性发作的影响

    Institute of Scientific and Technical Information of China (English)

    翟文慧; 李勇; 路晶凯; 王伟; 黄志刚

    2015-01-01

    Objective To investigate the effect of PM2.5 concentration on acute onset of chronic bronchitis. Method The clinical data of Beijing city center and other areas were selected to monitor and record daily fine particulate air pollution around the station PM2.5, PM10 concentrations, and the average temperature, maximum temperature, minimum temperature, wind speed, relative humidity, barometric pressure, visibility seven meteorological factors. The number of cases of chronic bronchitis in patients with acute exacerbation everyday was recorded. Result ①Daily hospital visits attack was positively correlated with the concentration of PM2.5, with the average, maximum and minimum temperatures were negatively correlated, and the minimum temperature associated with relatively greater;same barometric pressure, relative humidity, wind speed and visibility were negatively correlated.②The number of acute exacerbation of chronic bronchitis as PM2.5 level increased and growth. Conclusion Acute exacerbation of chronic bronchitis affected by the concentration of PM2.5, PM2.5 concentration monitoring can play a role in early warning of the onset of senile acute and chronic respiratory diseases.%目的:探讨PM2.5浓度对老年慢性支气管炎急性发作的影响。方法选择北京市城市中心区及其他地区的患者资料,监测并记录每日医院周围大气细颗粒污染物PM2.5和PM10的浓度以及平均气温、最高气温、最低气温、风速、相对湿度、气压、能见度等7项气象因子。记录两地区每日老年慢性支气管炎急性发作患者例数。结果①每日住院的老年慢性支气管炎急性发作患者例数同PM2.5浓度呈正相关,同平均气温、最高气温、最低气温均呈负相关,且与最低气温相关度更大;同气压、相对湿度、风速及能见度均呈负相关。②老年慢性支气管炎急性发作患者例数随PM2.5等级升高而增多。结论老年慢性

  10. PM2.5浓度对老年慢性支气管炎急性发作的影响%Research PM2.5 concentration on acute onset of chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    翟文慧; 李勇; 路晶凯; 王伟; 黄志刚

    2015-01-01

    Objective To investigate the effect of PM2.5 concentration on acute onset of chronic bronchitis. Method The clinical data of Beijing city center and other areas were selected to monitor and record daily fine particulate air pollution around the station PM2.5, PM10 concentrations, and the average temperature, maximum temperature, minimum temperature, wind speed, relative humidity, barometric pressure, visibility seven meteorological factors. The number of cases of chronic bronchitis in patients with acute exacerbation everyday was recorded. Result ①Daily hospital visits attack was positively correlated with the concentration of PM2.5, with the average, maximum and minimum temperatures were negatively correlated, and the minimum temperature associated with relatively greater;same barometric pressure, relative humidity, wind speed and visibility were negatively correlated.②The number of acute exacerbation of chronic bronchitis as PM2.5 level increased and growth. Conclusion Acute exacerbation of chronic bronchitis affected by the concentration of PM2.5, PM2.5 concentration monitoring can play a role in early warning of the onset of senile acute and chronic respiratory diseases.%目的:探讨PM2.5浓度对老年慢性支气管炎急性发作的影响。方法选择北京市城市中心区及其他地区的患者资料,监测并记录每日医院周围大气细颗粒污染物PM2.5和PM10的浓度以及平均气温、最高气温、最低气温、风速、相对湿度、气压、能见度等7项气象因子。记录两地区每日老年慢性支气管炎急性发作患者例数。结果①每日住院的老年慢性支气管炎急性发作患者例数同PM2.5浓度呈正相关,同平均气温、最高气温、最低气温均呈负相关,且与最低气温相关度更大;同气压、相对湿度、风速及能见度均呈负相关。②老年慢性支气管炎急性发作患者例数随PM2.5等级升高而增多。结论老年慢性

  11. Clinical observation of acute exacerbation of chronic bronchitis treated by Shenbai Zhike mixture%参百止咳合剂治疗慢性支气管炎急性发作30例临床观察

    Institute of Scientific and Technical Information of China (English)

    闫国友; 张立民; 王兴

    2011-01-01

    目的 观察在西医常规治疗基础上应用参百止咳合剂治疗慢性支气管炎急性发作的临床疗效.方法 将60例慢性支气管炎急性发作患者随机分为2组,对照组30例予西医常规治疗,治疗组30例在对照组治疗基础上予参百止咳合剂治疗,2组均7d为1个疗程,治疗2个疗程后观察疗效,进行症状积分及实验室指标血清白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)比较.结果 治疗组总有效率90.0%,对照组总有效率80.0%,2组总有效率比较差异有统计学意义(P<0.05),治疗组疗效优于对照组.2组治疗后症状积分均较本组治疗前降低(P<0.05),且治疗组治疗后症状积分低于对照组(P<0.05).2组治疗后血清IL-8、TNF-α水平均较本组治疗前降低(P<0.05),且治疗组治疗后血清IL-8、TNF-α水平低于对照组(P<0.05).结论 参百止咳合剂治疗慢性支气管炎急性发作疗效确切,值得临床推广.%Objective To investigate the clinical effect of acute exacerbation of chronic bronchitis treated by Shenbai Zhike mixture. Methods 60 patients with acute exacerbation of chronic bronchitis were randomly divided into two groups. Patients in control group received routine western medicine. Patients in treatment group were treated by Shenbai Zhike mixture combined with routine western medicine. The course was seven days in two groups. After two courses the curative effect was observed. Symptoms score, IL - 8 and TNF -α were compared for evaluation of clinical effect. Results The total effective rate in treatment group (90.0% ) was higher than that in control group (80.0% , P <0.05). The symptoms score after treatment was decreased in compared with that before treatment in two groups ( P <0.05). And the symptoms score in treatment group was lower than that in control group after treatment ( P < 0.05 ). The levels of IL - 8 and TNF - α in treatment group were lower than those in control group after treatment ( P <0

  12. Observation of acute attack stage of chronic bronchitis treated by Zhikepingchuan prescription%止咳平喘方治疗慢性支气管炎急性发作期120例疗效观察

    Institute of Scientific and Technical Information of China (English)

    刘秀艳; 刘俊敏; 程国静; 刘宏

    2014-01-01

    目的:观察止咳平喘方治疗慢性支气管炎急性发作期的临床疗效。方法将240例慢性支气管炎急性发作期患者随机分为2组,对照组120例予西医常规治疗,治疗组120例在对照组治疗基础上加止咳平喘方治疗。治疗10 d后观察2组治疗前后肺功能指标第1 s用力呼气容积占预计值百分比( FEV1%)和FEV1/用力肺活量( FVC),并观察治疗前后咳嗽、咯痰、喘息等临床症状变化以评价临床疗效。结果治疗组总有效率93.33%,对照组总有效率82.50%,2组总有效率比较差异有统计学意义(P<0.05),治疗组临床疗效优于对照组。治疗组治疗后肺功能指标FEV1%及FEV1/FVC与本组治疗前及对照组治疗后比较均明显提高(P<0.05)。结论止咳平喘方治疗慢性支气管炎急性发作期,肺功能改善明显,疗效确切,患者耐受良好,安全性高。%Objective To observe the clinical effect of acute attack stage of chronic bronchitis treated by Zhikepingchuan prescription .Methods 240 patients with acute attack stage of chronic bronchitis were randomly di-vided into control group ,which was treated by routine therapy and treatment group ,which was treated by Zhikeping-chuan prescription on the basis of control group treatment .Pulmonary function indicatrix ( FEV1% and FEV1/FVC) were observed after 10 days of treatment.The changes of clinical symptoms such as cough ,sputum,breathing before and after treatment were observed and clinical effect was evaluated .Results The total effective rate in treatment group (93.33%)was higher than that in control group (82.50%,P<0.05).FEV1% and FEV1/FVC in treatment group were increased as compared with those in control group after treatment ( P<0 .05 ) .Conclusion Zhikeping-chuan prescription on the treatment of acute attack stage of chronic bronchitis can significantly improve patients with lung function,definite curative effect,well tolerated

  13. 慢性支气管炎合并肺炎患者血浆中D-二聚体检测的临床意义%Clinical significance of plasma D-dimer detection in chronic bronchitis complicated with pneumonia patients

    Institute of Scientific and Technical Information of China (English)

    刘海波

    2015-01-01

    目的:探讨慢性支气管炎合并肺炎患者血浆中D-二聚体检测的临床意义。方法慢性支气管炎急性发作合并肺炎患者64例和肺栓塞患者30例,对其D-二聚体进行快速定量测定。结果慢性支气管炎急性发作合并肺炎患者和肺栓塞患者D-二聚体差异无统计学意义(P>0.05)。结论检测D-二聚体为判断慢性支气管炎是否合并肺部感染有一定的意义,且有助于判断炎症的轻重及病情变化。%Objective To investigate clinical significance of plasma D-dimer detection in chronic bronchitis complicated with pneumonia patients.Methods There were 64 cases of chronic bronchitis acute attack complicated with pneumonia and 30 cases of pulmonary embolism. Rapid quantitative determination was made for D-dimer in all patients.Results The difference of D-dimer had no statistical significance between chronic bronchitis acute attack complicated with pneumonia patients and pulmonary embolism patients (P>0.05). Conclusion Detection of D-dimer provides certain value for judging whether chronic bronchitis is complicated with pulmonary infection. This method is also helpful to judging status of inflammation and disease.

  14. Bedeutung von Mykoplasmenspezies bei Katzen mit chronischer Bronchitis/felinem Asthma

    OpenAIRE

    Richter, Petra

    2012-01-01

    Etiology of feline bronchial disease remains unknown so far. However, in human medicine, Mycoplasma spp. infections have been made responsible for the exacerbation of asthmatic lung disease for a long time. Aim of this study was to investigate the relevance of Mycoplasma spp. infections for the development of chronic bronchitis/feline asthma. For this purpose, lavage samples of lungs and nose and nasal swabs where taken from cats with chronic bronchitis/feline asthma and from cats without ...

  15. Evaluation of morphofunctional condition of mucociliary apparatus in bronchitis

    Energy Technology Data Exchange (ETDEWEB)

    Deinega, V.G.; Shlopov, V.G.; Lavrenova, G.V.

    1986-07-01

    Aim of present study is to determine condition of mucociliary apparatus of coal miners. The mucociliary transistor times (with aid of saccharin test) of individuals suffering uncomplicated dust-induced bronchitis are compared with those of healthy controls (men who have worked in mines 3 to 15 years without developing bronchitis). Subjects are divided into three groups depending on length of time they have worked in mines: 5, 6 to 11, and over 11 years. A table lists morphofunctional results of study measuring mucociliary transistor times, 1gA g/l of nasal micus and sputum, and relative volume of goblet cells and sweat glands of the three groups of miners and controls. Results show expression of morphofunctional destruction of the mucociliary apparatus of individuals with chronic bronchitis depends on length of time they are in contact with dust and clinical course of disease. In patients who spent more than 11 years in the mines, a protracted course of aggravation of bronchitis occurs, and in some cases progresses to destruction of the function of external breathing with obstruction of the airways by irremovable sputum and reflex bronchospasm. Study shows necessity of differential treatment of illness of one and same stage of bronchitis depending on length of time miner has worked in mines. 6 references.

  16. 老年慢性支气管炎患者负性情绪及自尊感临床现状分析%Clinical analysis of negative emotions and self-esteem of elderly patients with chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    侯莉; 李家容; 王颖琦; 王玉兰

    2011-01-01

    目的:探讨老年慢性支气管炎患者负性情绪及自尊感的临床现状.方法:分别选取110例老年慢性支气管炎、110例慢性支气管炎非老年成人患者、110例正常体检健康成人依次设为观察组、对照组、正常对照组,均应用焦虑自评量表、Avillo的情绪情感形容词量表及Rosenberg自尊量表调查、比较其相关评分,比较不同临床特征观察组患者评分的差别.结果:观察组患者焦虑评分高于对照组、正常对照组(P<0.01),而情绪情感及自尊评分低于对照组、正常对照组(P<0.05,P<0.01);观察组患者焦虑、情绪情感及自尊评分与性别、婚姻状况、子女状况、经济收入密切相关(P<0.05);观察组患者焦虑与情绪情感评分具有负相关性(P<0.05),焦虑与自尊评分具有负相关性(P<0.01),情绪情感评分与自尊评分具有正相关性(P<0.05).结论:老年慢性支气管炎患者表现为明显的焦虑情绪、情绪情感水平下降、自尊感下降,尤其是女性、无配偶、子女不在身边及经济收入低的患者表现更明显,在临床中可针对此特点进行相关护理,从根源上提高其心理水平.%Objective: To analyze the clinical situation of negative emotions and self - esteem of elderly patients with chronic bronchitis. Methods: 110 elderly patients with chronic bronchitis, 110 non - elderly adult patients with chronic bronchitis and 110 healthy adults with routine physical examination were respectively selected and taken as the observation group, control group and normal control group. The anxiety self - rating scale, Avillo emotional adjective scale and Rosenberg self - esteem scale were used to conduct a survey and compare the scores and the different clinical features among the patients. Results: The anxiety scores were higher in the observation group than the control and normal control groups ( P <0. 01 ); emotion and self - esteem scores were lower in the observation

  17. What Are the Signs and Symptoms of Bronchitis?

    Science.gov (United States)

    ... What Are the Signs and Symptoms of Bronchitis? Acute Bronchitis Acute bronchitis caused by an infection usually develops after you ... nose, vomiting, and diarrhea. The main symptom of acute bronchitis is a persistent cough , which may last 10 ...

  18. Clinical Practice Guidelines for Severe Chronic Obstructive Pulmonary Disease.

    OpenAIRE

    Niurka Mercedes Galende Hernández; Diosdania Alfonso Falcón; Carlos Alberto Martell Alonso; Alexis Díaz Mesa; Inti Santana Carballosa

    2009-01-01

    Clinical Practice Guidelines for Severe Chronic Obstructive Pulmonary Disease. This concept includes simple chronic bronchitis, asthmatic bronchitis, chronic obstructive bronchitis, and pulmonary emphysema; although this two last are the most commonly included. Risk factors, classification and treatment are commented, stressing the strategy of mechanical ventilation and the indications for mechanical invasive and no invasive ventilation. It includes assessment guidelines focused on the most i...

  19. A clinical study on treatment of acute exacerbations of chronic bronchitis with Sangpa Zhike decoction%桑杷止咳汤治疗慢性支气管炎急性发作的临床研究

    Institute of Scientific and Technical Information of China (English)

    严兴海; 蔡基鸿; 游方; 张蕾; 吕翠芬; 徐姗姗; 潘慧娟

    2014-01-01

    目的:观察桑杷止咳汤治疗慢性支气管炎急性发作的临床效果。方法选择2012年8月至2013年8月在新疆昌吉回族自治州中医医院门诊就诊的慢性支气管炎急性发作患者180例,按随机数字表法将患者分为桑杷止咳汤治疗组和西医治疗对照组,每组90例。两组均给予一般治疗,桑杷止咳汤治疗组在一般治疗的基础上加服桑杷止咳汤(组成:桑白皮10 g,枇杷叶10 g,鱼腥草10 g,蜜紫菀15 g,蜜款冬花6 g,浙贝母12 g,苏子10 g,白芥子6 g,桔梗10 g,白前12 g,陈皮6 g,百部6 g)每日1剂,水煎分2次服用;西医治疗对照组给予控制感染、止咳化痰等治疗方法,疗程均为7d。观察两组治疗前后中医证候疗效和咳嗽症状量化评分的变化。结果桑杷止咳汤治疗组治愈率明显高于西医治疗对照组〔70.00%(63/90)比33.33%(30/90),P<0.01〕。两组治疗前咳嗽症状量化评分比较差异无统计学意义,治疗后咳嗽症状量化积分均较治疗前明显降低,且以桑杷止咳汤治疗组降低更显著(分:1.66±1.12比4.36±2.32,P<0.01)。结论桑杷止咳汤治疗慢性支气管炎急性发作疗效显著。%Objective To observe the clinical effect of Sangpa Zhike decoction in the treatment of acute exacerbations of chronic bronchitis. Methods 180 patients with acute exacerbation of chronic bronchitis admitted to Autonomous Prefecture Hospital of traditional Chinese medicine(TCM)in Changji,Xinjiang,from August 2012 to August 2013 were enrolled. They were divided into Sangpa Zhike decoction treatment group and western medicine treatment control group by random number table,90 cases in each group. General treatments were given to the two groups. In the Sangpa Zhike decoction treatment group,additionally only oral Sangpa Zhike decoction was given(composition:Morus alba 10 g,loquat leaf 10 g,Houttuynia 10 g,honey aster 15 g,honey coltsfoot flower

  20. 112例误诊为支气管炎的老年慢性咳嗽病因分析%Etiological investigation of the 112 elderly patients with chronic cough misdiagnosed as bronchitis

    Institute of Scientific and Technical Information of China (English)

    林芳; 王浩彦

    2012-01-01

    目的 探讨老年患者慢性咳嗽的误诊及病因分布.方法 基层医院误诊为支气管炎的112例老年慢性咳嗽患者,采用咳嗽诊治指南制定的诊断程序,判断病因并予针对性治疗.结果 最终病因明确107例(95.54%),其中单一病因为89例(79.46%),复合病因为18例(16.07%).老年患者病因诊断前三位为胃食管返流性咳嗽、咳嗽变异型哮喘 、上气道咳嗽综合征,在女性患者和男性患者中分别占26.39%,20.83%,18.06%和29.31%,22.41%,18.97%.三者占慢性咳嗽病因的67.69%,其次是ACEI诱发的咳嗽.经特异性治疗后咳嗽明显减轻或消失为103例,有效率为91.96%,其余均为部分缓解.结论 老年慢性咳嗽病因复杂常被误诊,规范慢性咳嗽病因诊断程序对提高老年慢性咳嗽诊治水平有重要意义.%Objective The purpose of this study is to explore the etiology and misdiagnosis of the elderly patients with chronic cough. Methods A total of 112 the elderly patients ( 62 females, 50 males ) with chronic cough misdiagnosed as bronchitis by primary hospital were studied. Based on " Guideline on Diagnosis and Treatment of Chronic Cough" established by China Medical, the causes of chronic cough would be confirmed and given specific therapy. Results 107 of 112 patients( 95. 54% )were finally confirmed. Chronic cough due to a single cause was found in 89 patients ( 79. 46% ), and due to two causes in 18 patients ( 16. 07% ). The top three causes were gastroesophageal reflux cough ( GERC ), cough variant asthma ( CVA ), upper airway cough syndrome ( UACS ) and accounted for 67. 69% , followed by the ACEI-induced cough. The three causes accounted for 26. 39% , 20. 83% , 18. 06% in females and 29. 31% , 22. 41% , 18. 97% in male patients, respectively. After specific therapy based on diagnosis, cough cured and alleviated in 103 patients (91. 96% ); the rest are partially alleviated. Conclusions The cause of chronic cough in the elderly is complex and often

  1. An intervention with access to C-reactive protein rapid test reduces antibiotic overprescribing in acute exacerbations of chronic bronchitis and COPD

    DEFF Research Database (Denmark)

    F. Strykowski, David; Nielsen, Anni Brit Sternhagen; Llor, Carles;

    2015-01-01

    Background. In acute exacerbation of chronic obstructive pulmonary disease (AECOPD) antibiotic overprescribing leads to antimicrobial resistance and underprescribing may cause poor patient outcomes. Objective. This study aimed to evaluate changes in over- and underprescribing of antibiotics after...... two interventions to optimize antibiotic prescribing in AECOPD in Spain. Methods. In 2008 and 2009, general practitioners (GPs) registered patients in a 3-week period before and after interventions. Two types of intervention were conducted: GPs in the full-intervention group (FIG) were exposed...... to a multifaceted intervention and given access to C-reactive protein (CRP) rapid test; partial-intervention group (PIG) was only exposed to the multifaceted intervention. Overprescribing was defined as antibiotic given to type III* exacerbation (≤ one Anthonisen Criteria); underprescribing was defined...

  2. Role of PGE2 in Asthma and Nonasthmatic Eosinophilic Bronchitis

    OpenAIRE

    Beatriz Sastre; Victoria del Pozo

    2012-01-01

    Eosinophilic bronchitis is a common cause of chronic cough, which like asthma is characterized by sputum eosinophilia, but unlike asthma there is no variable airflow obstruction or airway hyperresponsiveness. Several studies suggest that prostaglandins may play an important role in orchestrating interactions between different cells in several inflammatory diseases such as asthma. PGE2 is important because of the multiplicity of its effects on immune response in respiratory diseases; however, ...

  3. Oral Fluoroquinolones in the Treatment of Pneumonia, Bronchitis and Sinusitis

    OpenAIRE

    Mittmann, Nicole; Jivraj, Farah; Wong, Angelina; Yoon, Alice

    2002-01-01

    BACKGROUND: Despite a relatively large number of clinical studies comparing oral fluoroquinolones to one antibiotic class comparator, there is limited information on the relative efficacy of different fluoroquinolones.OBJECTIVE: To examine the efficacy and tolerability of oral fluoroquinolones in the treatment of mild to moderate community-acquired pneumonia, acute exacerbations of chronic bronchitis and sinusitis.METHODS: A systematic review was undertaken with a MEDLINE search for antibioti...

  4. β-carotene protects rats against bronchitis induced by cigarette smoking

    Institute of Scientific and Technical Information of China (English)

    庞宝森; 王辰; 翁心植; 唐小奈; 张红玉; 牛淑洁; 毛燕玲; 辛平; 黄秀霞; 张海燕; 祝锦

    2003-01-01

    Objective To investigate the protective effects of β-carotene in rats against the development of chronic bronchitis induced by cigarette smoking. Results Long-term cigarette smoking caused an obvious increase in the amount of IL-6, IL-8 and LPO and a sharp decrease in the levels of NO and SOD in smoking animals compared to controls. β-carotene intake reversed all the changes induced by smoking and alleviated the pathological changes caused by chronic bronchitis. Conclusions Quantitative oral intake of β-carotene had protective effects against chronic bronchitis induced by long-term cigarette smoking, which was associated with the increased production of NO, the clearance of some oxidative free radicals (OFR) and the alleviation of chronic inflammation.

  5. 三拗片治疗急、慢性支气管炎风寒袭肺证80例分析%Treatment of acute and chronic bronchitis with syndrome of wind- cold attacking lung with San'ao tablets: An analysis of 80 cases

    Institute of Scientific and Technical Information of China (English)

    陈麒; 张炜; 张学超

    2012-01-01

    Objective To observe the clinical effect of treatment of acute and chronic bronchitis in acute stage with syndrome of wind - cold attacking lung with San'ao tablets. Methods Eighty cases of acute and chronic bronchitis in acute stage with syndrome of wind - cold attacking lung were treated with San'ao tablets for 7 days. The changes of clinical symptoms such as cough, sputum, wheeze were observed on the first day, the fifth and the seventh day. Results The total efficacy rate of San'ao tablets for treating acute and chronic bronchitis in acute stage with syndrome of wind-cold attacking lung was 93.75% . The main symptoms such as cough, expectoration and wheeze were significantly relieved. Conclusion San'ao tablets have an obvious clinical effect on a-cute and chronic bronchitis in acute stage with syndrome of wind- cold attacking King.%目的 观察三拗片治疗急性支气管炎和慢性支气管炎急性发作期风寒袭肺证的临床疗效.方法 将80例急性支气管炎和慢性支气管炎急性发作期风寒袭肺证患者给予三拗片治疗7d,观察患者治疗当日、第5天与第7天临床症状咳、痰、喘的变化.结果 三拗片对急、慢性支气管炎急性发作期风寒袭肺证患者的总有效率为93.75%,对主症咳嗽、咳痰和喘息具有明显改善作用.结论 三拗片可改善急性支气管炎和慢性支气管炎急性发作期风寒袭肺证患者的临床症.

  6. Determination of Plasma L-selectin and Tumor Necrosis Factor-αConcentrations in Patients with Chronic Bronchitis and Its Clinical Values%慢性支气管炎患者血浆L-selectin和TNF-α的检测及临床价值

    Institute of Scientific and Technical Information of China (English)

    汪清

    2013-01-01

    Objective To explore plasma L-selectin and tumor necrosis factor-a levels in patients with chronic bronchitis and their clinical values were evaluated. Methods Ninety-eight patients and equal number of healthy controls were enrolled into this stud-y. Plasma L-selectin and tumor necrosis factor-a concentrations were measured by ELISA. Results Plasma L-selectin and TNF-α levels were markedly higher in patients with chronic bronchitis than those in healthy controls (all P<0.01) , and in acute exacerbation than in clinical recovery (all P<0.01). They were significantly associated with diverse variables of arterial blood gas (all P<0.01). Conclusion L-selectin and tumor necrosis factor-a are involved in the pathophysiological process of chronic bronchitis and their determination can be beneficial to evaluate severity and prognostication of chronic bronchitis.%目的:揭示慢性支气管炎患者血浆L-选择素(L-selectin)和肿瘤坏死因子-α(TNF-α)浓度的变化,探讨其临床价值.方法:收集慢性支气管炎患者和同期体检健康者各98例.ELISA检测血浆L-selectin和TNF-α浓度.结果:慢性支气管炎患者血浆L-selectin和TNF-α浓度均显著高于健康体检正常者(均P<0.01),急性发作期患者血浆L-selectin和TNF-α浓度均显著高于临床缓解期患者(均P<0.01),慢性支气管炎患者血浆L-selectin和TNF-α浓度与动脉血气指标显著相关(均P<0.01).结论:L-selectin和TNF-α参与慢性支气管炎的病理生理过程,指标测定有助于评估慢性支气管炎病情轻重及预后.

  7. Antibiotic prescribing for acute bronchitis

    DEFF Research Database (Denmark)

    Llor, Carl; Bjerrum, Lars

    2016-01-01

    INTRODUCTION: Acute bronchitis is a self-limiting infectious disease characterized by acute cough with or without sputum but without signs of pneumonia. About 90% of cases are caused by viruses. AREAS COVERED: Antibiotics for acute bronchitis have been associated with an approximately half......-day reduction in duration of cough. However, at follow-up there are no significant differences in overall clinical improvement inpatients treated with antibiotics compared with those receiving placebo. Despite this, antibiotics are administered to approximately two thirds of these patients. This review...... discusses the reason for this antibiotic overprescription. Other therapies targeted to control symptoms have also demonstrated a marginal or no effect. EXPERT COMMENTARY: Clinicians should be aware of the marginal effectiveness of antibiotic therapy. Some strategies like the use of rapid tests, delayed...

  8. Get Smart: Know When Antibiotics Work - Bronchitis (Chest Cold)

    Science.gov (United States)

    ... Farm Get Smart About Antibiotics Week Bronchitis (Chest Cold) Language: English Español (Spanish) Recommend on Facebook Tweet ... types—acute bronchitis. Causes Acute bronchitis, or chest cold, often occurs after an upper respiratory infection like ...

  9. 慢性支气管炎急性发作采用阿奇霉素与左氧氟沙星门诊治疗的临床体会%Clinical Experience of Azithromycin and Levofloxacin in the Treatment of Acute Exacerbation of Chronic Bronchitis in Outpatient

    Institute of Scientific and Technical Information of China (English)

    杨鸿雁

    2014-01-01

    目的:研究慢性支气管炎急性发作采用阿奇霉素与左氧氟沙星门诊治疗的临床效果。方法选取68例患者将其分为治疗组和对照组,均34例,对比治疗效果。结果对比两组患者临床治疗总有效率和症状缓解时间,治疗组患者同对照组患者间具有明显差异性,P<0.05。结论阿奇霉素与左氧氟沙星对慢性支气管炎急性发作效果显著。%Objective The clinical effect of azithromycin and levofloxacin in the treatment of outpatients of acute exacerbations of chronic bronchitis. Methods 68 patients were divided into treatment group and control group were 34 cases, treatment effect, comparison. Results The clinical treatment of the two groups were compared and the total effective rate and the duration of remission, patients in the treatment group with the control has obvious differences between the groups with P<0.05. Conclusion Azithromycin and levofloxacin on acute attack of chronic bronchitis effect.

  10. Preventive and Curative Effects of Card Shu Ning Combined with Influenza Vaccine on Senile Chronic Bronchitis Complicated with Acute Infection%卡舒宁联合流感疫苗对老年性慢性支气管炎合并急性感染的防治效果

    Institute of Scientific and Technical Information of China (English)

    高忠翠; 李江涛; 展胜

    2011-01-01

    目的 观察卡舒宁联合流感疫苗对老年性慢性支气管炎合并急性感染的防治效果.方法 选择多年反复感染、咳嗽、咳痰、不同程度哮喘的老年慢性支气管炎患者138人,随机分为观察组73人,对照组65人.观察组接种流感疫苗后2周注射卡舒宁,每周2次,疗程3个月;对照组仅注射卡舒宁,方法 同观察组.1年后,对两组病例统一进行电话或人户随访,内容包括慢性支气管炎急性感染次数、急性感染时住院次数及急性感染时抗生素治疗疗程.结果 观察组患者慢性支气管炎急性感染次数和住院总次数明显减少,抗生素治疗疗程明显缩短,与对照组相比,差异均有统计学意义(P<0.01).结论 卡舒宁联合流感疫苗可明显提高老年性慢性支气管炎合并急性感染的防治效果.%Objective To observe the preventive and curative effects of Card Shu Ning combined with influenza vaccine on senile chronic bronchitis complicated with acute infection. Methods A total of 138 patients with senile chronic bronchitis complicated with cough, expectoration and asthma at various degrees, who were infected repeatedly during the past years, were divided into trial (73 cases) and control (65 cases) groups randomly. The patients in trial group were inoculated with influenza vaccine and injected with Card Shu Ning 2 weeks later, while those in control group were injected with Card Shu Ning alone, twice a week for 3 months. Telephone or in-home follow-up was performed on the patients one year later, including the times of acute infpction with chronic bronchitis, times of hospitalization due to acute infection and the course of treatment of acute infection with antibiotics. Results Compared with those in control group, the times of acute infection with chronic bronchitis and the times of hospitalization due to acute infection of patients in trial group decreased significantly, while the course of treatment with antibiotics was

  11. Anti-inflammatory drugs and experimental bronchitis.

    Science.gov (United States)

    Jeffery, P K

    1986-01-01

    Chronic bronchitis (chronic hypersecretion) and chronic bronchiolitis (small airways disease) are two conditions associated with cigarette smoking: both contribute to airflow obstruction in man, the latter associated with progressive deterioration in lung function. Mucous metaplasia and hyperplasia are characteristic histological changes. Experimentally, cigarette smoke given daily for two weeks, induces similar histological changes in the airways of specific pathogen-free rats, providing a suitable animal model for study: an early proliferation of basal cells, accompanied by mucous metaplasia of surface epithelial serous cells is followed by proliferation of newly formed mucous cells. There is also a significant increase in epithelial thickness due to cell hypertrophy without stratification or prior ulceration. Experimentally, secretory cell hyperplasia is inhibited completely or to varying degrees by prophylactic administration (intraperitoneal injection) of either indomethacin, flurbiprofen, dexamethasone, prednisolone, hydrocortisone (each at 2 or 4 mg/kg body weight) or a mucolytic drug, N-acetylcysteine(Nac), given orally as a 1% solution of the drinking water. Nac also inhibits the associated mucus-hypersecretion. It takes between 21 and 84 days, depending on airway level, for the increase in secretory cell number to return to control values (ie recover). Indomethacin and flurbiprofen (4 mg/kg, by ip injection) shorten recovery to between 4 and 9 days in intrapulmonary airways but have no effect on recovery time in the rat trachea. Nac is effective in 6 of 7 airway levels which showed cigarette smoke-induced mucous cell hyperplasia. In conclusion, in the rat, the response to cigarette smoke is one of mucous cell metaplasia and both basal and mucous cell proliferation. Cigarette smoke-induced mucous cell hyperplasia can be inhibited when selected drugs are given concurrently with the cigarette smoke: indomethacin, fluriprofen and Nac are also therapeutic.

  12. Anti-inflammatory drugs and experimental bronchitis.

    Science.gov (United States)

    Jeffery, P K

    1986-01-01

    Chronic bronchitis (chronic hypersecretion) and chronic bronchiolitis (small airways disease) are two conditions associated with cigarette smoking: both contribute to airflow obstruction in man, the latter associated with progressive deterioration in lung function. Mucous metaplasia and hyperplasia are characteristic histological changes. Experimentally, cigarette smoke given daily for two weeks, induces similar histological changes in the airways of specific pathogen-free rats, providing a suitable animal model for study: an early proliferation of basal cells, accompanied by mucous metaplasia of surface epithelial serous cells is followed by proliferation of newly formed mucous cells. There is also a significant increase in epithelial thickness due to cell hypertrophy without stratification or prior ulceration. Experimentally, secretory cell hyperplasia is inhibited completely or to varying degrees by prophylactic administration (intraperitoneal injection) of either indomethacin, flurbiprofen, dexamethasone, prednisolone, hydrocortisone (each at 2 or 4 mg/kg body weight) or a mucolytic drug, N-acetylcysteine(Nac), given orally as a 1% solution of the drinking water. Nac also inhibits the associated mucus-hypersecretion. It takes between 21 and 84 days, depending on airway level, for the increase in secretory cell number to return to control values (ie recover). Indomethacin and flurbiprofen (4 mg/kg, by ip injection) shorten recovery to between 4 and 9 days in intrapulmonary airways but have no effect on recovery time in the rat trachea. Nac is effective in 6 of 7 airway levels which showed cigarette smoke-induced mucous cell hyperplasia. In conclusion, in the rat, the response to cigarette smoke is one of mucous cell metaplasia and both basal and mucous cell proliferation. Cigarette smoke-induced mucous cell hyperplasia can be inhibited when selected drugs are given concurrently with the cigarette smoke: indomethacin, fluriprofen and Nac are also therapeutic

  13. 慢性阻塞性肺疾病与急性支气管炎肺功能的对比研究%The comparable study of lung function between patients with chronic obstructive pulmonary disease and patients with acute bronchitis

    Institute of Scientific and Technical Information of China (English)

    叶江枫; 袁名辉; 蒙育林

    2014-01-01

    目的:探讨脉冲振荡法(IOS)在慢性阻塞性肺疾病(COPD)、急性支气管炎的检测意义。方法选择100例COPD患者、100例急性支气管炎患者与正常对照者100例行常规肺通气功能及IOS检测。观察VC、FVC、FEV1%、FEV1/FVC、MMEF、VMAX、MVV;Fres、Zrs、R5、R20、R35、X5、Rc、Rp。结果 COPD组与正常组比较,VC、FVC、FEV1%、FEV1/FVC、MMEF、VMAX、MVV明显降低,P<0.05;Zrs、Fres、R5、R35、X5、R20、Rp明显升高,P<0.05。急性支气管炎组与正常组比较,VC、FVC、FEV1%、MVV明显降低,P<0.05;Zrs、Fres、R5、R20、R35、X5、Rp明显升高,P<0.01。COPD组与急性支气管炎组比较,VC、FVC、FEV1%、FEV1/FVC、MMEF、VMAX明显降低,P<0.01;Zrs、Fres、R5、R20、R35、X5、Rp明显升高,P<0.01。结论 COPD存在阻塞性和限制性通气功能障碍,急性支气管炎存在限制性通气功能障碍;COPD、急性支气管炎均存在总气道阻力、周边气道阻力、周边弹性阻力异常升高。COPD气道阻力升高更明显。%Objective To explore the clinical application value of impulse oscillometry (IOS) in patients with chronic obstructive pulmonary disease (COPD) and acute bronchitis. Methods To compare the parameters of pulmonary ventilation function with the results of respiratory impedance measured by impulse oscillometry in 100 patients with COPD group, 100 patients with acute bronchitis and 100 healthy adults.To observe VC, FVC, FEV1%, FEV1/FVC, MMEF, VMAX, MVV, Fres, Zrs, R5, R20, R35, X5, Rc, Rp. Results There were significant decrease in VC, FVC, FEV1%, FEV1/FVC, VMAX, MVV, P<0.05. There were significant rise in Zrs, Fres, R5, R35、X5, R20, Rp, P<0.05 in COPD group compared with normal group. There were decrease in VC, FVC, FEV1%, MVV, P<0.05;there were significant rise in Zrs, Fres, R5, R20, R35, X5, Rp, P<0.01 in acute bronchitis group compared with normal group. There were significant decrease in VC, FVC

  14. 应用雾化吸入利多卡因治疗慢性喘息型支气管炎急性发作的临床效果探讨%Application Clinical Effect on Atomizing Inhalation of Lidocaine for the Treatment of Chronic Wheezing Bronchitis Acute Episodes

    Institute of Scientific and Technical Information of China (English)

    芦万杰

    2015-01-01

    Objective To explore the clinical effect on atomization inhalation of lidocaine for the treatment of chronic wheezing bronchitis acute. Methods Selected 56 cases of chronic wheezing bronchitis acute episodes in our hospital as the observation group, patients with retrospective analysis of early departments of the clinical data of 55 patients with conditions similar to the control group. Control group patients received routine western medicine treatment, give atomization inhalation of lidocaine treatment group patients. To investigate the clinical therapeutic effect in both groups and contrast. Results Atomization inhalation of lidocaine treatment in the observation group of patients clinical treatment the total effective rate was 91.07%, significantly higher than the 78.18% of the control group treated with conventional treatment, compare the differences between groups,χ2=7.775, P<0.05,had statistically signiifcance. Conclusion The type of chronic wheezing bronchitis acute clinical treatment process, atomization inhalation of lidocaine therapy has good clinical effect, the recurrence rate is low.%目的:探讨雾化吸入利多卡因治疗慢性喘息型支气管炎急性发作的临床效果。方法选取在我院接诊的56例慢性喘息型支气管炎急性发作患者为观察组,回顾性分析早期我院接诊的55例条件相似的患者的临床资料,设为对照组。对照组患者接受常规西医治疗,给予观察组患者雾化吸入利多卡因治疗。对两组患者临床治疗效果进行调查和对比。结果接受雾化吸入利多卡因治疗的观察组患者临床治疗总有效率为91.07%,高于接受常规治疗的对照组患者的78.18%,χ2=7.775,P<0.05,差异具有统计学意义。结论在慢性喘息型支气管炎急性发作的临床治疗过程中,雾化吸入利多卡因治疗具有较好的临床效果,复发率较低。

  15. 沐舒坦雾化吸入治疗老年慢性支气管炎急性发作临床观察%Clinical observation of mucosolvan atomizing inhalation in the treatment of acute exacerbations of chronic bronchitis in eldly patients

    Institute of Scientific and Technical Information of China (English)

    孟蕾; 朱剑

    2015-01-01

    目的:观察沐舒坦雾化吸入治疗老年慢性支气管炎急性发作患者的临床疗效。方法:收治老年慢性支气管炎急性发作患者106例,分为雾化吸入组和静脉滴注组,雾化吸入组给予沐舒坦雾化吸入治疗,静脉滴注组给予沐舒坦静脉滴注治疗,比较两组疗效。结果:雾化吸入组的临床治疗总有效率明显高于静脉滴注组,咳嗽缓解时间、喘息缓解时间明显早于静脉滴注组,住院时间明显短于静脉滴注组(P<0.05)。结论:沐舒坦雾化吸入治疗老年慢性支气管炎急性发作患者起效更快,临床治疗效果更确切。%Objective:To explore the clinical effect of mucosolvan aerosol inhalation in the treatment of acute exacerbations of chronic bronchitis in eldly patients.Methods:106 elderly patients with acute exacerbation of chronic bronchitis patients were selected.They were divided into the atomizing inhalation group and intravenous infusion group.The atomizing inhalation group was given mucosolvan aerosol inhalation.The intravenous infusion group was given ambroxol intravenous drip treatment.We compared the efficacy of two groups.Results:In the atomizing inhalation group,the total efficiency of clinical treatment was significantly higher than that of intravenous infusion group;the remission time of cough,the remission time of breathing were significantly earlier than the intravenous infusion group;the hospitalization time was significantly shorter than the intravenous infusion group(P<0.05).Conclusion:The onset of mucosolvan aerosol inhalation in the treatment of acute exacerbations of chronic bronchitis in eldly patients was faster.Clinical therapeutic effect was more precise.

  16. Clinical Observation on Effect of Etimicin Sulfate Plus Cefmetazole Sodium on Acute Attack of Chronic Bronchitis%硫酸依替米星联合头孢美唑钠治疗慢性支气管炎急性发作的临床观察

    Institute of Scientific and Technical Information of China (English)

    袁艺

    2015-01-01

    目的:观察硫酸依替米星联合头孢美唑钠治疗慢性支气管炎急性发作的疗效。方法:将100例慢性支气管炎急性发作的患者随机分成对照组和研究组,每组50例。对照组单纯给予头孢美唑钠治疗,研究组给予硫酸依替米星联合头孢美唑钠治疗,进行临床疗效观察。结果:研究组临床有效率为89.5%,而对照组临床有效率为50.5%,研究组有效率明显高于对照组,差异有统计学意义( P<0.05)。结论:硫酸依替米星联合头孢美唑钠可有效治疗慢性支气管炎急性发作。%Objective:To observation the effect of etimicin sulfate plus cefmetazole sodium on the onset of chronic bronchitis .Methods:Ramdomly divide 100 cases of patients who were attacked acutely by chronic bronchitis into control group and research group ,50 cases for each .Treat the control group with cefmetazole sodium while the research group were treated with etimicin sulfate plus cefmetazole sodium .Make observa‐tion on the clinical effect .Results:The clinical effective rate of the research group was 89 .5% while that of the control group was 50 .5% ,the effective rate of the research group was obviously higher than that of the control group ,the difference was statistically significant ( P < 0 .05 ) .Conclusion:Etimicin sulfate plus cefmetazole sodium can effectively treat the acute attack of chronic bronchitis .

  17. Suhuang Capsule on Acute Attack of Senile Chronic Bronchitis the Curative Effects of the Patients With Observation%苏黄止咳胶囊对老年慢性支气管炎急性发作期患者的疗效观察

    Institute of Scientific and Technical Information of China (English)

    胡秋月

    2015-01-01

    目的:探讨苏黄止咳胶囊治疗老年慢性支气管炎急性发作期的临床疗效。方法选取124例慢性支气管炎急性发作期老年患者为研究对象,将其随机分为对照组和治疗组各62例,对照组给予常规治疗,治疗组在常规治疗的基础上采用苏黄止咳胶囊治疗,对比分析两组的治疗效果。结果治疗组患者临床治疗效果显著高于对照组,差异具有统计学意义(χ2=6.317,P<0.05)。结论采用苏黄止咳胶囊治疗处于慢性支气管炎急性发作期的老年患者,安全性高,治疗效果好,值得临床推广使用。%ObjectiveTo investigate the clinical curative effect of Suhuangzhike capsule in the treatment of senile chronic bronchitis in acute attack period. MethodsSelected 124 cases of acute exacerbation of chronic bronchitis in senile patients as the research object, then they were randomly divided into control group and treatment group with 62 cases in each group, the control group was given conventional treatment, the treatment group used Suhuangzhike capsule treatment on the basis of conventional therapy, compared two groups of treatment effect.ResultsThe clinical effect of the treatment of the patients in the treatment group was significantly higher than the control group, with signiifcant difference (χ2=6.317,P<0.05).Conclusion The use of Suhuangzhike capsule in the treatment of elderly patients with chronic bronchitis in acute attack period, high security, good therapeutic effect, is worthy of clinical use.

  18. Chronic obstructive pulmonary disease

    OpenAIRE

    NR Anthonisen

    2007-01-01

    The global prevalence of physiologically defined chronic obstructive pulmonary disease (COPD) in adults aged >40 yr is approximately 9-10 per cent. Recently, the Indian Study on Epidemiology of Asthma, Respiratory Symptoms and Chronic Bronchitis in Adults had shown that the overall prevalence of chronic bronchitis in adults >35 yr is 3.49 per cent. The development of COPD is multifactorial and the risk factors of COPD include genetic and environmental factors. Pathological changes in COPD are...

  19. Acute Bronchitis - Multiple Languages: MedlinePlus

    Science.gov (United States)

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Acute Bronchitis URL of this page: https://medlineplus.gov/languages/acutebronchitis.html Other topics A-Z A B ...

  20. 支气管哮喘和慢性喘息型支气管炎患者发作期呼吸音的分析研究%Spectral analysis of breath sounds in asthmatics and chronic asthmatic bronchitis during acute episode

    Institute of Scientific and Technical Information of China (English)

    辛晓峰; 殷凯生; 张希龙; 施毅; 黄小平

    2003-01-01

    Objectives:To evaluate and differentiate the spectral characteristics of the breath sounds in patients with asthmatics and chronic asthmatic bronchitis during episode. Methods:The breath sounds in 10 patients with asthmatics and 8 patients with chronic asthmatic bronchitis during episode were recorded by using microphone and computer and analyzed with FFT(fast-Fourier transform). Results: No difference of the expiratory frequency and intensity was found between the wheezes in patients with asthmatics[PF=(388.42±82.43)Hz, Q25%=(312.96±66.88)Hz,Q50%=(422.24±91.16)Hz,Q75%=(538.76±110.22)Hz, LSI=(23.21±0.82)dB,respectively],and chronic asthmatic bronchitis[PF=(359.43±45.46)Hz,Q25%=(296.98±67.84)Hz,Q50%=(421.43±91.82)Hz,Q75%=(523.287±60.16)Hz,LSI=(23.11±0.56)dB, respectively] during episode(P>0.05). However, during episode the inspiratory frequencies in patients with chronic asthmatic bronchitis[PF=(176.68 ±36.84)Hz,Q25%=(171.32±32.64)Hz,Q50%=(229.69±31.87)Hz,Q75%=(382.36±55.21)Hz, respectively] was significantly lower than that in asthmatics [PF=(354.21±67.58)Hz,Q25%=(286.42±53.68)Hz,Q50%=(386.77±74.18)Hz,Q75%=(554.68±84.72)Hz,respectively,P0.05);发作期慢喘支患者吸气时的频率比发作期哮喘患者低[两组的PF,Q25%,Q50%,Q75%分别为(176.68±36.84)Hz,(171.32±32.64)Hz,(229.69±31.87)Hz,(382.36±55.21)Hz和(354.21±67.58)Hz,(286.42±53.68)Hz,(386.77±74.18)Hz,(554.68±84.72)Hz,P<0.05或P<0.01]. 结论:哮喘和慢喘支患者发作期呼吸音的频谱分析,有助于发作期哮喘和发作期慢喘支的诊断和鉴别诊断.

  1. Clinical Effect of Atomization Inhalation of Lidocaine for Treatment of Acute Attack of Chronic Asthmatic Bronchitis%雾化吸入利多卡因治疗慢性喘息型支气管炎急性发作的临床疗效

    Institute of Scientific and Technical Information of China (English)

    张欢

    2015-01-01

    ObjectiveTo discuss and study the clinical effect and significance of atomization inhalation of lidocaine for treatment of acute attack of chronic asthmatic bronchitis.MethodRandomly selected patients in pediatric acute episode of chronic asthmatic bronchitis in 100 cases and divided into combination group and common group both with 50 cases. Common group was given routine treatment and combination group was given atomization inhalation of lidocaine on basis of routine treatment. After different treatments, total effective rate and blood gas analysis of the 2 groups were compared. ResultTotal effective rate of combination group was 100% obviously higher than common group 78%(P<0.05). Changes of blood gas analysis of combination group were obvious superior to common group (P<0.05).ConclusionAtomization inhalation of lidocaine for treatment of acute attack of chronic asthmatic bronchitis has signiifcant clinical effect. It can effectively restrain smooth muscle contraction, reduce bronchial hyperresponsiveness and obviously relieve breathing phenomenon of patients within a short time. Besides, it can also relieve edema and inlfammatory reaction, and effectively control acute attack of bronchitis.%目的:研究利多卡因雾化吸入用于治疗慢性喘息型支气管炎发作的临床疗效与意义。方法随机选取就诊于我院儿科慢性喘息型支气管炎急性发作患儿100例。分组为联合组、普通组,各50例。其中为普通组患者进行常规治疗;联合组给在常规治疗基础上联合雾化吸入利多卡因。比较两组患者经过不同治疗后总有效率、血气分析等指标。结果两组患者不同治疗后总有效率的比较,显示治疗后联合利多卡因雾化吸入患者总有效率为100%,显著优于常规治疗组78%(P<0.05),联合组治疗效果较好;治疗前后血气分析值比较显示联合组与普通组治疗前血气分析值无显著差异(P>0.05)。治疗后联合组血

  2. The Efficacy of Tanreqing for Treating Acute Exacerbation of Chronic Bronchitis and Its Impact on Immunoglobulin Levels of IgA, IgG and IgM%痰热清治疗慢性支气管炎急性发作的疗效及对免疫球蛋白IgA、IgG和IgM的影响

    Institute of Scientific and Technical Information of China (English)

    王琼

    2013-01-01

      [目的]探讨痰热清治疗慢性支气管炎(chronic bronchitis,CB)急性发作的疗效及对免疫球蛋白IgA、IgG和IgM的影响。[方法]将自2011年2月至2012年2月我院收治的60例CB急性发作患者随机分为对照组和观察组,每组30例。所有患者均给予基础治疗,对照组在基础治疗上给予庆大霉素、地塞米松、α糜蛋白酶雾化吸入,观察组则在基础治疗上给予痰热清注射液静脉滴注,观察两组患者的疗效、临床症状改善情况及免疫球蛋白IgA、IgG和IgM水平变化情况。[结果]观察组患者的总有效率为96.67%显著高于对照组的80%(χ2=4.04,P<0.05);观察组各临床症状的改善时间均明显短于对照组(P<0.05);观察组治疗后免疫球蛋白IgA、IgG和IgM的水平显著低于对照组(P<0.05)。[结论]采用痰热清治疗CB急性发作疗效显著,能有效缩短临床症状的缓解时间,改善免疫球蛋白IgA、IgG和IgM的水平,增强机体免疫功能,促进患者尽快康复。%  [Objective]To explore the clinical efficacy of Tanreqing for treating acute exacerbation of chronic bronchitis and its impact on immunoglobulin levels of IgA, IgG and IgM. [Methods] 60 cases with acute exacerbation of chronic bronchitis admitted in our hospital from February 2010 to February 2012 were randomly divided into control group and observation group, and each group had 30 cases. Al of the patients were given basic treatment; the control group was given gentamicin, dexamethasone and alpha chymotrypsin aerosol inhalation on the basis of the basic treatment, while the observation group was given Tanreqing intravenous injection;the efficacy, clinical symptoms improving situation and the changes of immunoglobulin levels of IgG and IgM were compared between the two groups. [Results] The total effective rate of the observation group was 96.67% significantly higher than 80% of the control group(χ2=4.04); the

  3. Clinical Practice Guidelines for Severe Chronic Obstructive Pulmonary Disease. Guía de práctica clínica para el tratamiento de la enfermedad pulmonar obstructiva crónica grave.

    OpenAIRE

    Inti Santana Carballosa; Alexis Díaz Mesa; Carlos Alberto Martell Alonso; Diosdania Alfonso Falcón; Niurka Mercedes Galende Hernández

    2009-01-01

    Clinical Practice Guidelines for Severe Chronic Obstructive Pulmonary Disease. This concept includes simple chronic bronchitis, asthmatic bronchitis, chronic obstructive bronchitis, and pulmonary emphysema; although this two last are the most commonly included. Risk factors, classification and treatment are commented, stressing the strategy of mechanical ventilation and the indications for mechanical invasive and no invasive ventilation. It includes assessment guidelines focused on the most i...

  4. Role of PGE2 in Asthma and Nonasthmatic Eosinophilic Bronchitis

    Directory of Open Access Journals (Sweden)

    Beatriz Sastre

    2012-01-01

    Full Text Available Eosinophilic bronchitis is a common cause of chronic cough, which like asthma is characterized by sputum eosinophilia, but unlike asthma there is no variable airflow obstruction or airway hyperresponsiveness. Several studies suggest that prostaglandins may play an important role in orchestrating interactions between different cells in several inflammatory diseases such as asthma. PGE2 is important because of the multiplicity of its effects on immune response in respiratory diseases; however, respiratory system appears to be unique in that PGE2 has beneficial effects. We described that the difference in airway function observed in patients with eosinophilic bronchitis and asthma could be due to differences in PGE2 production. PGE2 present in induced sputum supernatant from NAEB patients decreases BSMC proliferation, probably due to simultaneous stimulation of EP2 and EP4 receptors with inhibitory activity. This protective effect of PGE2 may not only be the result of a direct action exerted on airway smooth-muscle proliferation but may also be attributable to the other anti-inflammatory actions.

  5. 氨溴索、布地奈德雾化吸入联合治疗慢支急性发作的临床疗效%Ambroxol and Budesonide Aerosol Inhalation in Treatment of Acute Exacerbation of Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    董凤霞

    2015-01-01

    目的:探讨氨溴索、布地奈德雾化吸入联合治疗慢支急性发作的临床疗效。方法选取2012年10月~2014年9月在我院接受治疗的慢支急性发作患者108例,并根据患者具体情况分为观察组和对照组各54例,对照组采用常规综合方法进行治疗,观察组在对照组基础上加用氨溴索、布地奈德雾化吸入联合治疗,观察并比较两组的治疗效果。结果观察组患者治疗总有效率为94.5%,对照组为85.2%,观察组明显高于对照组,P<0.05,具有统计学意义;治疗前两组患者体温、C反应蛋白、白细胞、血沉、中性粒细胞均值无明显差异,治疗后均下降,下降幅度观察组明显高于对照组,P<0.05,具有统计学意义。结论氨溴索、布地奈德雾化吸入联合治疗慢支急性发作疗效显著,安全稳定。%ObjectiveTo study the effect of Ambroxol and Budesonide aerosol inhalation in treatment of acute exacerbation of chronic bronchitis. MethodsFrom October 2012 to September 2014 in our hospital, 108 cases of patients with acute attack of chronic bronchitis were divided into observation group and control group 54 cases, control group was treated with the conventional synthesis methods, observation group in the control group on the basis of the total ammonia bromine rope, combination treatment with budesonide atomization inhalation, observed and compared the therapeutic effect of two groups.Results The observation group of patients treatment the total effective rate was 94.5%, control group was 85.2%, the observation group is signiifcantly higher than the control group,P<0.05, there was statistically signiifcant. Two groups of patients before treatment temperature, c-reactive protein, white blood cells, blood sedimentation, neutrophils mean no signiifcant difference, decreased after treatment, the decline in observation group is significantly higher than the control group,P<0.05, with statistical

  6. 哌拉西林他唑巴坦治疗慢性支气管炎急性发作120例临床疗效观察%Piperacillin Tazobactam Treatment of Acute Exacerbation of Chronic Bronchitis, 120 Cases of Clinical Observation

    Institute of Scientific and Technical Information of China (English)

    高成兵; 汪平; 幸仕洪; 王珏

    2013-01-01

    目的:研究分析采用哌拉西林他唑巴坦治疗慢性支气管炎急性发作的临床措施和效果。方法回顾性分析2010年3月~2012年3月,我院收治的120例慢性支气管炎急性发作患者的临床资料,按照患者入院治疗的时间顺序将其随机分为两组,单号入院患者为观察组,共60例,采用哌拉西林他唑巴坦联合氨溴索治疗;双号入院患者为对照组,60例,采用氨苄西林联合氨溴索治疗。比较两组患者的临床疗效和各项临床症状缓解的时间。结果治疗后观察组患者的治疗有效率为96.67%,对照组患者的治疗有效率为86.67%,两组比较差异明显,具有统计学意义,(P<0.05);且观察组患者的各项临床症状的缓解时间短于对照组,两组比较差异明显,具有统计学意义,(P<0.05)。结论哌拉西林他唑巴坦是治疗慢性支气管炎急性发作的良好药物,临床疗效显著,安全性高,值得临床推广。%Objective: To study the methods and Effect of treating acute exacerbation of chronic bronchitis with piperacillin-tazobactam. Methods: Choosed 120 cases of acute exacerbation of chronic bronchitis to divide into study group and controlled group with 60 cases in each group. The study group were treated with piperacillin-tazobactam and ambroxol, the controlled group were treated with ampicillin and ambroxol. Compared the clinicallEffect and remission time. Results: The clinicallEffect of study group was 96.67%, higher than 86.67% of controlled group. And the remission time of study group was shorter than controlled group. Conclusion: Treating acute exacerbation of chronic bronchitis with piperacillin-tazobactam receive bet er Effects and high safety to extend in clinic.

  7. 阿奇霉素与左氧氟沙星治疗慢性支气管炎急性发作的疗效和安全性比较研究%Azithromycin and levofloxacin in treatment of acute exacerbations of chronic bronchitis curative effect and the security of the comparative study

    Institute of Scientific and Technical Information of China (English)

    王艳碧

    2012-01-01

      目的:探讨阿奇霉素与左氧氟沙星治疗慢性支气管炎急性发作的临床疗效.方法:本研究于2010年8月~2012年2月分别采用阿奇霉素和左氧氟沙星治疗慢性支气管炎急性发作患者,并对两种药物治疗的临床疗效和不良反应进行对比研究.结果:研研究组在用药3d、6d 及用药后1d 的临床总有效率与对照组相比较均无明显差异(P 均﹥0.05).研究组在治疗过程中出现1例恶心、胃部不舒服,1例头晕;对照组则在治疗过程中出现2例恶心、1例头晕.经对症治疗后症状均缓解,未影响治疗.结论:使用口服阿奇霉素5 d 与口服左氧氟沙星7 d 治疗慢性支气管炎急性发作均有较好的临床治疗效果,且安全性良好,值得临床推广使用.%  Objective: To investigate the azithromycin and levofloxacin in treatment of acute exacerbations of chronic bronchitis clinical curative effect. Methods: This study in 2010 August ~ 2012 year in February respectively with azithromycin and levofloxacin in the treatment of patients with acute exacerbations of chronic bronchitis, and two kinds of drugs for the treatment of clinical efficacy and adverse reaction were studied. Results: the research group at the 3D 6D medication, treatment and after 1D total clinical efficiency as compared with the control group showed no significant difference ( P al ﹥0.05). The study group emerged in the course of treatment in 1 cases of nausea, upset stomach, 1 cases of dizziness;while the control group emerged in the course of treatment in 2 cases, 1 cases of dizziness nausea. After the symptomatic treatment, symptoms were relieved in al patients, no impact. Conclusion: the use of oral azithromycin 5 d with oral levofloxacin in treatment of acute exacerbations of chronic bronchitis 7 d has good clinical curative effect, and good safety, is worthy of clinical use.

  8. 沙丁胺醇雾化吸入联合沉香饮加减治疗慢性喘息性支气管炎急性发作的疗效观察%Efficacy observation on treating acute exacerbation of chronic asthmatic bronchitis with the albuterol inhalation joint the Chenxiang decoction

    Institute of Scientific and Technical Information of China (English)

    潘君贤

    2012-01-01

      Objective:To analyze and investigate the clinical effect of treating acute exacerbation chronic asthmatic bronchitis with the albuterol inhalation of joint the Chenxiang decoction. Methods: Retrospective analyzing 20 patients with acute exacerbation of chronic asthmatic bronchitis in our hospital from January 2009 to December 2011, and plus salbutamol solution (1ml, 2 times a day) joint the Chenxiang decoction for treatment, in accordance with the evaluation standard, the analysis and observation of clinical efficacy in the treatment of this group of patients. Results: ①After treatment, markedly in 12 cases, effective in 7 cases, and ineffective in 1 case, the total effective rate of 95.0%. During treatment, symptoms of palpitations in 2 cases, 1 case of patient had symptoms of nausea, and adverse reactions disappear after medicine withdrawal. ②Pre-treatment lung function parameters (FEV1 and PEFR) were significantly lower than after treatment (2 weeks), and both showed a statistically significant difference. Conclusion:Treating acute exacerbation of chronic asthmatic bronchitis with the albuterol inhalation joint the Chenxiang decoction, its clinical efficacy, should be generalized and applied in clinical.%  目的:对沙丁胺醇雾化吸入联合沉香饮加减用于治疗慢性喘息性支气管炎的临床疗效进行分析与探究.方法:回顾性分析了2009年1月~2011年12月入住我院的20例慢性喘息性支气管炎急性发作的患者的临床资料,并向其加用沙丁胺醇雾化吸入溶液(1ml,每天2次)联合沉香饮加减饮进行治疗,按照相关的疗效评定标准,对本组患者在该种治疗方法下的临床疗效进行分析与观察.结果:①经过上述治疗方法的应用,显效例数12例,有效例数7例,无效例数为1例总有效率为95.0%.在治疗过程中,有2例出现心悸症状,1例出现恶心症状,停药之后不良反应均消失.②治疗前肺功能参数(FEV1与PEFR)要明显低

  9. Effect observation of salmeterol xinafoate and fluticasone propionate pow-der for inhalation in the treatment of acute attack of chronic bronchitis%沙美特罗替卡松粉吸入剂治疗慢性支气管炎急性发作的效果观察

    Institute of Scientific and Technical Information of China (English)

    肖亮

    2014-01-01

    目的:观察沙美特罗替卡松粉吸入剂治疗慢性支气管炎急性发作的临床效果。方法选取本院2012年2月~2014年2月收治的68例慢性支气管炎急性发作患者为研究对象,按照随机数字表法将其分为两组,各34例。对照组采取吸氧、平喘、抗感染、吸痰等常规治疗,实验组在对照组基础上加用沙美特罗替卡松粉吸入剂治疗,比较两组的治疗效果及不良反应情况。结果实验组中临床治愈19例(55.88%),显效8例(23.53%),好转5例(14.71%),总有效率为94.12%,对照组临床治愈14例(41.18%),显效8例(23.53%),好转3例(8.82%),总有效率为73.53%,实验组的总有效率明显高于对照组(P0.05)。结论沙美特罗替卡松粉吸入剂能明显改善临床症状,且不良反应少,值得在慢性支气管炎急性发作患者中进一步应用。%Objective To observe the clinical effect of salmeterol xinafoate and fluticasone propionate powder for in-halation in the treatment of acute attack of chronic bronchitis. Methods From February 2012 to February 2014,68 pa-tients with acute attack of chronic bronchitis admitted into our hospital were selected as research objects and they were evenly divided into two groups according to the random number table method.In the control group,regular treatment in-cluding oxygen uptake,anti-asthma,anti-infection,and aspiration of sputum were provided, while in the experimental group,on the basis of treatment the control group, salmeterol xinafoate and fluticasone propionate powder for inhalation was added. The clinical effect and adverse reaction in the two groups were compared. Results In the experimental group,19 cases (55.88%) were cured clinically,8 cases were markedly efective (23.53%),5 cases (14.71%) were improved, the total effective rate was 94.12%,while in the control group,14 cases (41.18%) were clinically cured,8 cases (23.53%) were markedly efective,3 cases (8.82%) were improved

  10. 负离子氧疗慢性支气管炎急性发作期的临床观察及感染控制对疗效的影响%Clinical observation on negative ion of oxygen therapy for patients with acute exacerbation of chronic ;bronchitis and the efifcacy of anti-infection measures

    Institute of Scientific and Technical Information of China (English)

    于德海

    2013-01-01

    目的:探讨高浓度负离子氧疗在慢性支气管炎急性发作期治疗中的临床应用价值。方法将本院收治的106例慢性支气管炎急性发作期患者随机分为观察组和对照组,每组患者53例。对照组给予常规西药治疗,观察组在对照组基础上给予高浓度负离子氧疗,观察两组的临床症状改善情况、肺功能改善情况、实验室生化指标及临床疗效。结果观察组临床总有效率为90.6%(48/53),对照组临床总有效率为73.5%(39/53),两组差异有统计学意义(P <0.05),观察组咳嗽、喘息及肺啰音等临床症状改善情况均显著优于对照组(P <0.05),观察组FEV1、FEV1/FVC、p(O2)及p(CO2)的肺功能各项指标改善情况显著优于对照组(P <0.05),观察组CRP、PCT及WBC等实验室生化指标也均显著优于对照组(P <0.05)。结论高浓度负离子氧疗能显著提高慢性支气管炎急性发作期的临床疗效,具有重要的临床应用价值。%Objective To explore clinical efifcacy of high concentration negative ions of oxygen therapy for patients with acute exacerbation of chronic bronchitis. Methods Total of 106 patients with acute exacerbation of chronic bronchitis were randomly divided into two groups with 53 cases in each group, the observation group treated with the conventional therapy plus adjuvant treatment of high concentration negative ions of oxygen were compared with the control group treated with conventional therapy. The clinical efifcacy of the two groups was observed. Results The clinical efifciency of the observation group was 90.6%, the clinical efifciency of the control group was 73.5%, the clinical symptoms and serum biochemical indicators of the observation group was signiifcantly better than that of the control group, with signiifcant difference (P<0.05). Conclusions High concentration negative ions of oxygen therapy can signiifcantly improve the clinical

  11. 9 CFR 113.327 - Bronchitis Vaccine.

    Science.gov (United States)

    2010-01-01

    ... respiratory signs or death shall be counted as failures. Two-stage sequential testing may be conducted if the.... Final container samples of completed product shall be tested for virus titer using the procedure... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Bronchitis Vaccine. 113.327...

  12. Role of P G E 2 in Asthma and Nonasthmatic Eosinophilic Bronchitis

    OpenAIRE

    Sastre, Beatriz; del Pozo, Victoria

    2012-01-01

    Eosinophilic bronchitis is a common cause of chronic cough, which like asthma is characterized by sputum eosinophilia, but unlike asthma there is no variable airflow obstruction or airway hyperresponsiveness. Several studies suggest that prostaglandins may play an important role in orchestrating interactions between different cells in several inflammatory diseases such as asthma. PGE2 is important because of the multiplicity of its effects on immune response in respiratory diseases; however, ...

  13. Passive smoking effects on wheezy bronchitis.

    Science.gov (United States)

    Bener, A; Al-Frayh, A; Ozkaragoz, F; Al-Jawadi, T Q

    1993-05-01

    Previous epidemiological studies have associated parental smoking with an increased incidence of lower respiratory illness and bronchial asthma. The aim of the present study was to investigate the association between parental smoking habits and diagnosed wheezy bronchitis in schoolchildren in Saudi Arabia. In a cross-sectional study 3,041 schoolchildren ages seven to 12 years were randomly selected in Dammam, Jeddah, and Riyadh; representing three different geoclimatic regions of Saudi Arabia. Standardized questionnaires were used in our study. The results showed that paternal smoking had a significant effect on the frequency of wheezing when paternal and maternal smoking were considered separately. There was no considerable variation in the parental smoking habits in three areas. The association between passive smoking and diagnosed wheezy bronchitis and frequency of wheezing attacks was highly significant (P<0.0001). Overall, the results tend to confirm that there is a real effect of passive smoking on the respiratory health of children and that paternal smoking is a risk factor for wheezy bronchitis in children. PMID:17590665

  14. Observation of the application effect of health education nursing intervention in elderly patients with chronic bronchitis%老年慢性支气管炎患者应用健康教育护理干预的效果观察

    Institute of Scientific and Technical Information of China (English)

    王晨英

    2015-01-01

    Objective:To explore the application effect of health education nursing intervention in elderly patients with chronic bronchitis.Methods:120 elderly patients with chronic bronchitis were selected.They were randomly divided into the control group and the observation group with 60 cases in each group.The control group was given routine nursing intervention,and the observation group was given nursing intervention of health education.Results:In the control group,23 cases(38.33%) changed their bad living habits,31 cases(51.67%) quitted smoking and drinking;in the observation group,50 cases(83.33%) changed their bad living habits,59 cases(98.33% ) quitted smoking and drinking,the different was statistically significant(P<0.05).In the control group,the average recurrence time was 115 days,average one treatment time was 12 days;in the observation group,the average recurrence time was 194 days,average one treatment time was 7 days.Conclusion:Health education nursing intervention had very good curative effect in clinic.It can shorten the course of treatment in patients,and delay patients recurrence time.%目的:探讨对老年慢性支气管炎患者应用健康教育护理干预的治疗效果。方法:收治老年慢性支气管炎患者120例,随机平均分为对照组和观察组,对照组采用常规护理干预,观察组采用健康教育护理干预。结果:对照组逐渐改变自己的生活习惯23例(38.33%),戒烟戒酒31例(51.67%);观察组改变自己不良的生活习惯50例(83.33%),戒烟戒酒59例(98.33%)。两组比较,差异有统计学意义(P<0.05)。对照组再次复发时间平均115 d,1个疗程时间平均12 d;观察组再次复发时间平均194 d,1个疗程时间平均7 d。结论:健康教育护理干预在临床上取得了非常好的疗效,可缩短患者的治疗时间,延缓患者的再次复发时间。

  15. Infectious Bronchitis Vaccination Protocols for Laying Hens

    OpenAIRE

    A. Sulaiman; Roberts, J.R.

    2011-01-01

    A research was conducted to investigate the effects of vaccination protocols for Infectious Bronchitis (IB) on egg production, egg quality, and IB antibody titres of laying hens. Different initial vaccination (Control, VicS eye, VicS spray, VicS water, A3 eye, A3 spray, and A3 water) for IB were administered to day-old Isa Brown hens. Half the hens were revaccinated regularly during lay whereas the other hens were not vaccinated. Results showed that initial vaccination treatment had signific...

  16. Risco aumentado de sintomas respiratórios e bronquite crônica em mulheres que utilizam biocombustíveis na Nigéria Increased risk of respiratory symptoms and chronic bronchitis in women using biomass fuels in Nigeria

    Directory of Open Access Journals (Sweden)

    Olufemi Olumuyiwa Desalu

    2010-08-01

    Full Text Available OBJETIVO: Determinar a associação de sintomas respiratórios e bronquite crônica com o uso de biocombustíveis entre mulheres habitantes de áreas rurais do estado de Ekiti, sudoeste da Nigéria. MÉTODOS: De janeiro a junho de 2009, realizou-se um estudo transversal com uma amostra de 269 mulheres adultas. Um questionário adaptado do European Community Respiratory Health Survey foi aplicado para a obtenção de dados sobre características sociodemográficas, tipo de combustível utilizado para a preparação de alimentos, sintomas respiratórios e história de tabagismo. Todas as participantes foram convidadas a realizar espirometria. RESULTADOS: Das 269 mulheres no estudo, 161 (59,9% utilizavam biocombustíveis para a preparação de alimentos. As mulheres que utilizavam biocombustíveis relataram mais sintomas respiratórios que aquelas que não os utilizavam - tosse (13,7% vs. 3,7%; sibilância (8,7% vs. 2,8%; dor no peito (7,5% vs. 1,9%; falta de ar (11,8% vs. 6,5%; sintomas nasais (9,3% vs. 4,6%; e bronquite crônica (10,6% vs. 2,8%. A análise multivariada por regressão logística confirmou que o uso de biocombustíveis está associado às seguintes variáveis: tosse (OR = 4,82; p = 0,01; bronquite crônica (OR = 3,75; p = 0,04; sibilância (OR = 2,22; p = 0,23; dor no peito (OR = 3,82; p = 0,09; falta de ar (OR = 1,54; p = 0,35; e sintomas nasais (OR = 2,32; p = 0,20. Todos os parâmetros espirométricos avaliados (VEF1, CVF, VEF1/CVF e PFE foram menores nas mulheres que utilizavam biocombustíveis do que naquelas que não os utilizavam. CONCLUSÕES: Nossos resultados enfatizam a necessidade de se substituir o uso de biocombustíveis nos domicílios pelo de um tipo de combustível atóxico, como eletricidade ou gás.OBJECTIVE: To determine whether respiratory symptoms and chronic bronchitis are associated with the use of biomass fuels (BMFs among women residing in rural areas of the Ekiti State, in southwestern Nigeria. METHODS

  17. Acupuncture as method of treatment and arresting progress of dust-induced bronchitis

    Energy Technology Data Exchange (ETDEWEB)

    Baburina, E.B.; Bykova, E.A.

    1983-10-01

    Acupuncture is an effective therapy for treatment of dust-induced bronchitis. It can be used independently or in combination with medicaments. Fifty men were divided into two groups of 20 and 30. One group was treated by acupuncture alone, the other with combined therapy. Acupuncture produced excellent results; combined treatment, good and satisfactory results. Since acupuncture reduced the possibility of complications, allergic reactions and side effects due to medication, it is an excellent means of preventing progress of dust-induced bronchitis. Patients experience 9 months remission of symptoms after treatment with acupuncture while medical therapy alone only relieves them for 1 to 1 1/2 months. Patients with chronic dust-induced bronchitis should receive a second course of acupuncture in 6 to 8 months to prevent recurrence of symptoms and progress of disease. Because of insufficient study of lasting effects of acupuncture, final conclusions about its effectiveness cannot be made, however, current evidence indicates it is a highly useful therapy. 6 references.

  18. Vascular endothelial growth factor as a non-invasive marker of pulmonary vascular remodeling in patients with bronchitis-type of COPD

    Directory of Open Access Journals (Sweden)

    Nomura Saeko

    2007-03-01

    Full Text Available Abstract Background Several studies have indicated that one of the most potent mediators involved in pulmonary vascular remodeling is vascular endothelial growth factor (VEGF. This study was designed to determine whether airway VEGF level reflects pulmonary vascular remodeling in patients with bronchitis-type of COPD. Methods VEGF levels in induced sputum were examined in 23 control subjects (12 non-smokers and 11 ex-smokers and 29 patients with bronchitis-type of COPD. All bronchitis-type patients performed exercise testing with right heart catheterization. Results The mean pulmonary arterial pressure (mPAP and pulmonary vascular resistance (PVR after exercise were markedly increased in all bronchitis-type patients. However, both parameters after exercise with breathing of oxygen was significantly lower than in those with breathing of room air. To attenuate the effect of hypoxia-induced pulmonary vasoconstriction during exercise, we used the change in mPAP or PVR during exercise with breathing of oxygen as a parameter of pulmonary vascular remodeling. Change in mPAP was significantly correlated with VEGF level in induced sputum from patients with chronic bronchitis (r = 0.73, p = 0.0001. Moreover, change in PVR was also correlated with VEGF level in those patients (r = 0.57, p = 0.003. Conclusion A close correlation between magnitude of pulmonary hypertension with exercise and VEGF level in bronchitis-type patients could be observed. Therefore, these findings suggest the possibility that VEGF level in induced sputum is a non-invasive marker of pulmonary vascular remodeling in patients with bronchitis-type of COPD.

  19. Molecular mechanisms of recurrent acute obstructive bronchitis in infants

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    Abaturov A.E.

    2015-06-01

    Full Text Available The article discusses the clinical and immunological features and mechanisms of recurrent acute obstructive bronchitis in infants. We have examined 102 children aged from 6 months to 3 years with acute obstructive bronchitis and signs of respiratory insufficiency of the I-II degree. There were 28 children with recurrent acute obstructive bronchitis and 74 patients with acute obstructive bronchitis,developed for the first time. We determined the concentration of total IgE, content of IFN-і, IL-4, IL-12 and IL-13 in serum by ELISA and the expression of the transcription factor NF-єB in lymphocytes of peripheral blood by flow cytometry in all the children. High level of IL-12 as compared to physiological norms in the dynamics of the disease was the characteristic feature of the children of both groups. And it was the factor, which detected a voltage of cell-mediated immune response and inflammation. The second specific feature was the high concentration of IgE. It was shown that the transcription factor NF-єB determined the cytokine status at the beginning of the disease, and in the period of convalescence. That fact did not depend on the number of previous acute obstructive bronchitis. However, there were violations of the mechanisms of NF-єB-associated signaling pathways activation, which manifested itself in an advantageous enhancement of the chains, determining the production of Th2-associated cytokines in children with recurrent acute obstructive bronchitis.

  20. Living Well with COPD: Chronic Bronchitis and Emphysema

    Science.gov (United States)

    ... the airways • These are not the same as anabolic steroids,which are muscle-building steroids often misused by ... not to be confused Air sacs (alveoli) with anabolic steroids used by athletes and others to build muscles. ...

  1. Infectious Bronchitis Vaccination Protocols for Laying Hens

    Directory of Open Access Journals (Sweden)

    A. Sulaiman

    2011-12-01

    Full Text Available A research was conducted to investigate the effects of vaccination protocols for Infectious Bronchitis (IB on egg production, egg quality, and IB antibody titres of laying hens. Different initial vaccination (Control, VicS eye, VicS spray, VicS water, A3 eye, A3 spray, and A3 water for IB were administered to day-old Isa Brown hens. Half the hens were revaccinated regularly during lay whereas the other hens were not vaccinated. Results showed that initial vaccination treatment had significant effects on hen day egg production and egg quality of egg weight, shell reflectivity, shell breaking strength, shell thickness, albumen height, Haugh Units, and IB antibody titre levels, but had no effect on percentage of shell and yolk colour. Egg weight and shell reflectivity were less favourable in the control hens. In contrast, shell breaking strength and shell thickness were highest for the group that initially received A3 vaccine in water. However, regular revaccination had some deleterious effects on egg production and egg quality. There were no significant effects of revaccination on IB antibody titres. It is concluded that there was little advantage in regularly revaccinating laying hens for IB virus, since they had received appropriate initial vaccination.

  2. Early History of Chronic Obstructive Pulmonary Disease 1808-1980.

    Science.gov (United States)

    Watson, R Ann; Pride, Neil B

    2016-04-01

    COPD has become a more popular research area in the last 3 decades, yet the first clear descriptions of acute and chronic bronchitis were in 1808. This brief history, comprehensively referenced, leads us through the early developments in respiratory physiology and their applications. It emphasises the early history of chronic bronchitis and emphysema in the 19(th) and early 20(th) centuries, long before the dominant effects of cigarette smoking emerged. This remains relevant to developing countries today. PMID:26418529

  3. Cerebral Lipiodol Embolism after Lymphatic Embolization for Plastic Bronchitis.

    Science.gov (United States)

    Kirschen, Matthew P; Dori, Yoav; Itkin, Maxim; Licht, Daniel J; Ichord, Rebecca; Vossough, Arastoo

    2016-09-01

    An adolescent with plastic bronchitis due to congenital heart disease had altered mental status after an interventional lymphatic procedure in which lipiodol contrast was used. Neuroimaging revealed cerebral lipiodol embolization due to direct shunting between lymphatic channels and pulmonary veins. Cerebral lipiodol embolization is a potential neurologic morbidity associated with interventional lymphatic procedures. PMID:27297208

  4. Radiation bronchitis in lung cancer patient treated with stereotactic radiation therapy

    International Nuclear Information System (INIS)

    We report a case of chronic radiation bronchitis that developed in a patient with lung cancer treated with fractionated stereotactic radiation therapy. A 73-year-old woman with a medically inoperable T1N0M0 adenocarcinoma of the lung was treated with stereotactic radiation therapy. By using eight non-coplanar ports, 50 Gy/5 fractions was delivered in two weeks. At four weeks, a partial response was obtained with no acute adverse reaction. She developed severe cough at six months. Fiberoptic bronchoscopy revealed thick circumferentially coated bronchial mucosa in close proximity to the tumor site. At 12 months, follow-up study confirmed marked stenotic change in the B6 segmental bronchus without tumor progression. (author)

  5. Prevalence of chronic conditions – Chronic Airflow Obstruction

    OpenAIRE

    Ireland and Northern Ireland Population Health Observatory (INIsPHO)

    2012-01-01

    IPH has estimated and forecast clinical diagnosis rates of CAO among adults for the years 2010, 2015 and 2020. In the Republic of Ireland, the data are based on the Survey of Lifestyle, Attitudes and Nutrition (SLÁN) 2007. The data describe the number of people who report that they have experienced doctor-diagnosed chronic bronchitis, chronic obstructive lung (pulmonary) disease, or emphysema in the previous 12 months (annual clinical diagnosis). Data is available by age and sex for each Loca...

  6. β-Blockers and All-Cause Mortality in Adults with Episodes of Acute Bronchitis: An Observational Study.

    Directory of Open Access Journals (Sweden)

    Frans H Rutten

    Full Text Available Recent observational studies suggest that β-blockers may improve long-term prognosis in patients with chronic obstructive pulmonary disease (COPD. We assessed whether β-blocker use improves all-cause mortality in patients with episodes of acute bronchitis.An observational cohort study using data from the electronic medical records of 23 general practices in the Netherlands. The data included standardized information about daily patient contacts, diagnoses, and drug prescriptions. Cox regression was applied with time-varying treatment and covariates.The study included 4,493 patients aged 45 years and older, with at least one episode of acute bronchitis between 1996 and 2006. The mean (SD age of the patients was 66.9 (11.7 years, and 41.9% were male. During a mean (SD follow up period of 7.7 (2.5 years, 20.4% developed COPD. In total, 22.7% had cardiovascular comorbidities, resulting in significant higher mortality rates than those without (51.7% vs. 12.0%, p<0.001. The adjusted hazard ratio of cardioselective β-blocker use for mortality was 0.62 (95% confidence interval [CI], 0.50-0.77, and 1.01 (95% CI 0.75-1.36 for non-selective ones. Some other cardiovascular drugs also reduced the risk of mortality, with adjusted HRs of 0.60 (95% CI 0.46-0.79 for calcium channel blockers, 0.88 (95% CI 0.73-1.06 for ACE inhibitors/angiotensin receptor blockers, and 0.42 (95% CI 0.31-0.57 for statins, respectively.Cardiovascular comorbidities are common and increase the risk of mortality in adults with episodes of acute bronchitis. Cardioselective β-blockers, but also calcium channel blockers and statins may reduce mortality, possibly as a result of cardiovascular protective properties.

  7. E Protein Prokaryotic Expression of Avian Infectious Bronchitis Virus

    Institute of Scientific and Technical Information of China (English)

    WEI Ping; ZHANG Fang; MING Xiaobo; ZENG Xiangwei; ZHU Yuqing; WANG Lin

    2008-01-01

    The small envelope protein (E) gene of avian infectious bronchitis virus (IBV) M41 strain was cloned,and then it was subeloned into prokaryotic expressing vector pGEX-6P-1.The recombinant plasmid was transformed into E.coli.BL21 and induced by IPTG.SDS-PAGE result showed that when objective protein fused with GST (about 20 ku), the relative molecular mass of fusion protein was 38 ku.It indicated that objective protein was about 12.4 ku.The result showed that E protein was expressed successfully, it was useful to the subsequent E protein research.

  8. Comorbidity between chronic obstructive pulmonary disease and type 2 diabetes

    DEFF Research Database (Denmark)

    Meteran, Howraman; Backer, Vibeke; Kyvik, Kirsten Ohm;

    2015-01-01

    BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality and is associated with several systemic diseases, such as type 2 diabetes. It has been suggested that comorbidity between COPD and type 2 diabetes is due to shared genetic factors. AIM: To examine...... the relationship between type 2 diabetes and chronic bronchitis and COPD in adult twins, and to examine to what extent comorbidity between these diseases is explained by shared genetic or environmental factors. METHODS: Questionnaire data on chronic bronchitis and hospital discharge data on diagnosed COPD in 13......,649 twins, aged 50-71 years, from the Danish Twin Registry were cross-linked with hospital discharge diagnosis data on type 2 diabetes from the Danish National Patient Registry. RESULTS: The risk of type 2 diabetes was higher in persons with symptoms of chronic bronchitis than in those without symptoms (3...

  9. Europe: history, current situation and control measures for infectious bronchitis

    Directory of Open Access Journals (Sweden)

    RC Jones

    2010-06-01

    Full Text Available The emergence and nature of different strains of infectious bronchitis virus (IBV in Europe are described. Infectious bronchitis (IB is the most important endemic viral respiratory disease where highly pathogenic Newcastle disease and avian influenza are not present. IB was first described in the UK in 1948 and identified as Massachusetts type. In the 1970s and 80s new serotypes were reported in Holland and elsewhere and new vaccines were developed. The 1990s saw the emergence of the major variant commonly called 793B, again needing a new vaccine. Two novel types have been recognised since 2000, Italy 02 and QX. Italy 02 appears to be well controlled by the use of two different live vaccines (H120 and the 793B-related 4/91 while for QX, associated with nephritis in young birds and silent layers, new vaccines are in development. The use of two vaccines as above is a widely used protocol and is capable of protecting against a wide range of different types. Alternative approaches to IB vaccination are discussed. The importance of constant surveillance for prevalent and novel IBV types is emphasised and the value of experimental infections in chickens to determine the pathogenesis and pathology of new types in addition to testing efficacy of vaccines is outlined.

  10. Pathogenesis and Diagnostic Approaches of Avian Infectious Bronchitis

    Directory of Open Access Journals (Sweden)

    Faruku Bande

    2016-01-01

    Full Text Available Infectious bronchitis (IB is one of the major economically important poultry diseases distributed worldwide. It is caused by infectious bronchitis virus (IBV and affects both galliform and nongalliform birds. Its economic impact includes decreased egg production and poor egg quality in layers, stunted growth, poor carcass weight, and mortality in broiler chickens. Although primarily affecting the respiratory tract, IBV demonstrates a wide range of tissues tropism, including the renal and reproductive systems. Thus, disease outcome may be influenced by the organ or tissue involved as well as pathotypes or strain of the infecting virus. Knowledge on the epidemiology of the prevalent IBV strains in a particular region is therefore important to guide control and preventions. Meanwhile previous diagnostic methods such as serology and virus isolations are less sensitive and time consuming, respectively; current methods, such as reverse transcription polymerase chain reaction (RT-PCR, Restriction Fragment Length Polymorphism (RFLP, and sequencing, offer highly sensitive, rapid, and accurate diagnostic results, thus enabling the genotyping of new viral strains within the shortest possible time. This review discusses aspects on pathogenesis and diagnostic methods for IBV infection.

  11. Relation between Ascites Syndrome Incidence and Infectious Bronchitis in Broiler Chickens by ELISA Method

    Directory of Open Access Journals (Sweden)

    Adel Feizi

    2011-12-01

    Full Text Available Infectious bronchitis is an acute viral disease with high contagious and mortality among chicks. The aim of this study was to survey of relation between ascites syndrome incidence and infectious bronchitis in broiler chickens by ELISA method in Iran. Eight Ross strain broiler farm affected by infectious bronchitis were selected in this study. Blood samples were gathered early stages of disease and blood sampling was repeated two times with seven days interval. ELISA serologic test was used for approving the determination of infectious bronchitis. In addition, in order to differential diagnosis of Newcastle and influenza (H9N2 some relevant experiments were conducted. The rate of mortality in any farm during rearing, autopsy and the cause of mortality were recorded. Ascites cases were calculated in terms of prevalence. The growth parameters, FCR, final weight, total consumption of grain at each farm were calculated and mentioned. Based on obtained results in this study, the mean rate of mortality caused by ascites syndrome has been increased meaningfully in herds affected by infectious bronchitis compared with control group. In eight understudied farms affected by infectious bronchitis, the mean rate of Ascites mortality was 3% such that the mean rate of Ascites mortality was 0.5% at previous periods. Based on relevant results also final weight mean in affected herds with infectious bronchitis was lower compared with previous periods. Meanwhile, FCR in affected herds with infectious bronchitis was high compared with healthy herds. In this research demonstrated that there is positive correlation between infectious bronchitis and Ascites syndrome and the correlation is significant (p<0.05.

  12. 呼吸训练与吸入类固醇提高慢性喘息型支气管炎患者肺功能的探讨%Respiratory training combined with inspiratory steroid hormone on pulmonary function of patients with asthmatic bronchitis

    Institute of Scientific and Technical Information of China (English)

    邹天士

    2001-01-01

    @@Background:Repeated cough,expectoration and asthma are main clinical manifestations of chronic asthmatic bronchitis,and pulmonary function is also affcted.Intraairway and around nonspecific inflammation are common in clinic.Steroid hormone could effectly treat nonspecific inflammation and hyperactivity of air way,and improve pulmonary function. Objective:To investigate effect of respiratory training and inspiratory steroid hormone on pumlonary function of patients with asthmatic bronchitis. Unit:Internal Respiratory oepartmant of the First People's Hospital of Zhaoqing Subjects:74 patients with athmatic bronchitis during 1998~ 2000,49 male,25 female aged 47~ 81 years(averagely 63.3 years),and disease course lasted for 2~ 21 years(averagely 12.6 years).

  13. Impact of Ambient Air Pollution on the Differential White Blood Cell Count in Patients with Chronic Pulmonary Disease

    OpenAIRE

    Brüske, Irene; Hampel, Regina; Socher, Martin M.; Rückerl, Regina; Schneider, Alexandra; Heinrich, Joachim; Oberdörster, Günter; Wichmann, H.-Erich; Peters, Annette

    2010-01-01

    Epidemiologic studies report associations between particulate air pollution and increased mortality from pulmonary diseases.To examine whether the exposure to ambient gaseous and particulate air pollution leads to an alteration of the differential white blood cell count in patients with chronic pulmonary diseases like chronic bronchitis, chronic obstructive pulmonary disease, and asthma.

  14. Genetic diversity and selection regulates evolution of infectious bronchitis virus.

    Science.gov (United States)

    Toro, Haroldo; van Santen, Vicky L; Jackwood, Mark W

    2012-09-01

    Conventional and molecular epidemiologic studies have confirmed the ability of infectious bronchitis virus (IBV) to rapidly evolve and successfully circumvent extensive vaccination programs implemented since the early 1950s. IBV evolution has often been explained as variation in gene frequencies as if evolution were driven by genetic drift alone. However, the mechanisms regulating the evolution of IBV include both the generation of genetic diversity and the selection process. IBV's generation of genetic diversity has been extensively investigated and ultimately involves mutations and recombination events occurring during viral replication. The relevance of the selection process has been further understood more recently by identifying genetic and phenotypic differences between IBV populations prior to, and during, replication in the natural host. Accumulating evidence suggests that multiple environmental forces within the host, including immune responses (or lack thereof) and affinity for cell receptors, as well as physical and biochemical conditions, are responsible for the selection process. Some scientists have used or adopted the related quasispecies frame to explain IBV evolution. The quasispecies frame, while providing a distinct explanation of the dynamics of populations in which mutation is a frequent event, exhibits relevant limitations which are discussed herein. Instead, it seems that IBV populations evolving by the generation of genetic variability and selection on replicons follow the evolutionary mechanisms originally proposed by Darwin. Understanding the mechanisms underlying the evolution of IBV is of basic relevance and, without doubt, essential to appropriately control and prevent the disease.

  15. Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control study.

    Directory of Open Access Journals (Sweden)

    Jill Koshiol

    Full Text Available BACKGROUND: Chronic obstructive pulmonary disease (COPD has been consistently associated with increased risk of lung cancer. However, previous studies have had limited ability to determine whether the association is due to smoking. METHODOLOGY/PRINCIPAL FINDINGS: The Environment And Genetics in Lung cancer Etiology (EAGLE population-based case-control study recruited 2100 cases and 2120 controls, of whom 1934 cases and 2108 controls reported about diagnosis of chronic bronchitis, emphysema, COPD (chronic bronchitis and/or emphysema, or asthma more than 1 year before enrollment. We estimated odds ratios (OR and 95% confidence intervals (CI using logistic regression. After adjustment for smoking, other previous lung diseases, and study design variables, lung cancer risk was elevated among individuals with a history of chronic bronchitis (OR = 2.0, 95% CI = 1.5-2.5, emphysema (OR = 1.9, 95% CI = 1.4-2.8, or COPD (OR = 2.5, 95% CI = 2.0-3.1. Among current smokers, association between chronic bronchitis and lung cancer was strongest among lighter smokers. Asthma was associated with a decreased risk of lung cancer in males (OR = 0.48, 95% CI = 0.30-0.78. CONCLUSIONS/SIGNIFICANCE: These results suggest that the associations of personal history of chronic bronchitis, emphysema, and COPD with increased risk of lung cancer are not entirely due to smoking. Inflammatory processes may both contribute to COPD and be important for lung carcinogenesis.

  16. Purine Bases in Blood Plasma of Patients with Chronic Pulmonary Diseases

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    Larissa E. Muravluyova

    2012-09-01

    Full Text Available The article is focused on the study of purine bases and intermediates of purine catabolism in plasma of patients with chronic obstructive bronchitis and idiopathic interstitial pneumonia. Decrease of adenine and hypoxantine in plasma of patients with idiopathic interstitial pneumonia was registered. Increase of guanine in plasma of patients with chronic obstructive pulmonary disease was established.

  17. CT findings of plastic bronchitis in children after a Fontan operation

    Energy Technology Data Exchange (ETDEWEB)

    Goo, Hyun Woo [University of Ulsan College of Medicine, Department of Radiology and Research Institute of Radiology, Asan Medical Center, Seoul (Korea); Jhang, Won Kyoung; Kim, Young Hwee; Ko, Jae Kon; Park, In Sook [University of Ulsan College of Medicine, Department of Pediatric Cardiology, Asan Medical Center, Seoul (Korea); Park, Jeong-Jun; Yun, Tae-Jin; Seo, Dong-Man [University of Ulsan College of Medicine, Department of Pediatric Cardiac Surgery, Asan Medical Center, Seoul (Korea)

    2008-09-15

    Plastic bronchitis is a rare cause of acute obstructive respiratory failure in children. Life-threatening events are much more frequent in patients with repaired cyanotic congenital heart disease, and most frequent following a Fontan operation. Commonly, the diagnosis is not made until bronchial casts are expectorated. Detailed CT findings in plastic bronchitis have not been described. To describe the CT findings in plastic bronchitis in children after a Fontan operation. Three children with plastic bronchitis after a Fontan operation were evaluated by chest CT. Bronchial casts were spontaneously expectorated and/or extracted by bronchoscopy. Airway and lung abnormalities seen on CT were analyzed in the three children. CT demonstrated bronchial casts in the central airways with associated atelectasis and consolidation in all children. The affected airways were completely or partially obstructed by the bronchial casts without associated bronchiectasis. The airway and lung abnormalities rapidly improved after removal of the bronchial casts. CT can identify airway and lung abnormalities in children with plastic bronchitis after a Fontan operation. In addition, CT can be used to guide bronchoscopy and to monitor treatment responses, and thereby may improve clinical outcomes. (orig.)

  18. CT findings of plastic bronchitis in children after a Fontan operation

    International Nuclear Information System (INIS)

    Plastic bronchitis is a rare cause of acute obstructive respiratory failure in children. Life-threatening events are much more frequent in patients with repaired cyanotic congenital heart disease, and most frequent following a Fontan operation. Commonly, the diagnosis is not made until bronchial casts are expectorated. Detailed CT findings in plastic bronchitis have not been described. To describe the CT findings in plastic bronchitis in children after a Fontan operation. Three children with plastic bronchitis after a Fontan operation were evaluated by chest CT. Bronchial casts were spontaneously expectorated and/or extracted by bronchoscopy. Airway and lung abnormalities seen on CT were analyzed in the three children. CT demonstrated bronchial casts in the central airways with associated atelectasis and consolidation in all children. The affected airways were completely or partially obstructed by the bronchial casts without associated bronchiectasis. The airway and lung abnormalities rapidly improved after removal of the bronchial casts. CT can identify airway and lung abnormalities in children with plastic bronchitis after a Fontan operation. In addition, CT can be used to guide bronchoscopy and to monitor treatment responses, and thereby may improve clinical outcomes. (orig.)

  19. Lactate dehydrogenase concentration in nasal wash fluid indicates severity of rhinovirus-induced wheezy bronchitis in preschool children.

    Science.gov (United States)

    Cangiano, Giulia; Proietti, Elena; Kronig, Marie Noelle; Kieninger, Elisabeth; Sadeghi, Christine D; Gorgievski, Meri; Barbani, Maria Teresa; Midulla, Fabio; Tapparel, Caroline; Kaiser, Laurent; Alves, Marco P; Regamey, Nicolas

    2014-12-01

    The clinical course of rhinovirus (RV)-associated wheezing illnesses is difficult to predict. We measured lactate dehydrogenase concentrations, RV load, antiviral and proinflammatory cytokines in nasal washes obtained from 126 preschool children with RV wheezy bronchitis. lactate dehydrogenase values were inversely associated with subsequent need for oxygen therapy. lactate dehydrogenase may be a useful biomarker predicting disease severity in RV wheezy bronchitis.

  20. Chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    V K Vijayan

    2013-01-01

    Full Text Available The global prevalence of physiologically defined chronic obstructive pulmonary disease (COPD in adults aged >40 yr is approximately 9-10 per cent. Recently, the Indian Study on Epidemiology of Asthma, Respiratory Symptoms and Chronic Bronchitis in Adults had shown that the overall prevalence of chronic bronchitis in adults >35 yr is 3.49 per cent. The development of COPD is multifactorial and the risk factors of COPD include genetic and environmental factors. Pathological changes in COPD are observed in central airways, small airways and alveolar space. The proposed pathogenesis of COPD includes proteinase-antiproteinase hypothesis, immunological mechanisms, oxidant-antioxidant balance, systemic inflammation, apoptosis and ineffective repair. Airflow limitation in COPD is defined as a postbronchodilator FEV1 (forced expiratory volume in 1 sec to FVC (forced vital capacity ratio <0.70. COPD is characterized by an accelerated decline in FEV1. Co morbidities associated with COPD are cardiovascular disorders (coronary artery disease and chronic heart failure, hypertension, metabolic diseases (diabetes mellitus, metabolic syndrome and obesity, bone disease (osteoporosis and osteopenia, stroke, lung cancer, cachexia, skeletal muscle weakness, anaemia, depression and cognitive decline. The assessment of COPD is required to determine the severity of the disease, its impact on the health status and the risk of future events (e.g., exacerbations, hospital admissions or death and this is essential to guide therapy. COPD is treated with inhaled bronchodilators, inhaled corticosteroids, oral theophylline and oral phosphodiesterase-4 inhibitor. Non pharmacological treatment of COPD includes smoking cessation, pulmonary rehabilitation and nutritional support. Lung volume reduction surgery and lung transplantation are advised in selected severe patients. Global strategy for the diagnosis, management and prevention of Chronic Obstructive Pulmonary Disease

  1. Lung Compliance and Chronic Obstructive Pulmonary Disease

    Directory of Open Access Journals (Sweden)

    D. Papandrinopoulou

    2012-01-01

    Full Text Available Chronic obstructive pulmonary disease, namely, pulmonary emphysema and chronic bronchitis, is a chronic inflammatory response of the airways to noxious particles or gases, with resulting pathological and pathophysiological changes in the lung. The main pathophysiological aspects of the disease are airflow obstruction and hyperinflation. The mechanical properties of the respiratory system and its component parts are studied by determining the corresponding volume-pressure (P-V relationships. The consequences of the inflammatory response on the lung structure and function are depicted on the volume-pressure relationships.

  2. ANESTHETIC CONSIDERATION S IN CHRONIC OBSTRUCTIVE PULMON ARY DISEASE

    Directory of Open Access Journals (Sweden)

    Awati

    2015-03-01

    Full Text Available Chronic obstructive pulmonary disease (COPD is a spectrum of diseases that includes emphysema, chronic bronchitis, and small airway disease. It i s characterized by progressive increased resistance to breathing. Patients with marked obstructive pulmonary disease are at increased risk for both intraoperative and Postoperative pulmonary complications. These patients require thorough preoperative prepa ration, meticulous intraoperative management & postoperative care. This article describes anesthetic considerations in a patient with COPD.

  3. Pharmacotherapy challenges of Fontan-associated plastic bronchitis: a rare pediatric disease.

    Science.gov (United States)

    Brooks, Kristina; Caruthers, Regine L; Schumacher, Kurt R; Stringer, Kathleen A

    2013-09-01

    Pediatric pharmacotherapy is often challenging due to the paucity of available clinical data on the safety and efficacy of drugs that are commonly used in children. This quandary is even more prevalent in children with rare diseases. Although extrapolations for dosing and administration are often made from available adult data with similar disease states, this translation becomes even more problematic in rare pediatric diseases. Understanding of rare disease pathophysiology is typically poor, and few, if any, effective therapies have been studied and identified. One condition that illustrates these issues is plastic bronchitis, a rare, most often pediatric disease that is characterized by the production of obstructive bronchial airway casts. This illness primarily occurs in children with congenital heart disease, often after palliative surgery. Plastic bronchitis is a highly clinically relevant and therapeutically challenging problem with a high mortality rate, and, a generally accepted effective pharmacotherapy regimen has yet to be identified. Furthermore, the disease is ill defined, which makes timely identification and treatment of children with plastic bronchitis difficult. The pharmacotherapies currently used to manage this disease are largely anecdotal and vary between the use of macrolide antibiotics, mucolytics, bronchodilators, and inhaled fibrinolytics in a myriad of combinations. The purpose of this review is 2-fold: first, to highlight the dilemma of treating plastic bronchitis, and second, to bring attention to the continuing need for studies of drug therapies used in children so safe and effective drug regimens can be established, particularly for rare diseases.

  4. Association between Ambient Air Pollution and Outpatient Visits for Acute Bronchitis in a Chinese City

    Institute of Scientific and Technical Information of China (English)

    GUO Li Juan; ZHAO Ang; CHEN Ren Jie; KAN Hai Dong; KUANG Xing Ya

    2014-01-01

    Objective To investigate the short-term association between outdoor air pollution and outpatient visits for acute bronchitis, which is a rare subject of research in the mainland of China. Methods A time-series analysis was conducted to examine the association of outdoor air pollutants with hospital outpatient visits in Shanghai by using two-year daily data (2010-2011). Results Outdoor air pollution was found to be associated with an increased risk of outpatient visits for acute bronchitis in Shanghai. The effect estimates of air pollutants varied with the lag structures of the concentrations of the pollutants. For lag06, a 10μg/m3 increase in the concentrations of PM10, SO2, and NO2 corresponded to 0.94%(95%CI:0.83%, 1.05%), 11.12%(95%CI:10.76%, 11.48%), and 4.84%(95%CI: 4.49%, 5.18%) increases in hospital visits for acute bronchitis, respectively. These associations appeared to be stronger in females (P Conclusion Our analyses have provided the first evidence that the current air pollution level in China has an effect on acute bronchitis and that the rationale for further limiting air pollution levels in Shanghai should be strengthened.

  5. Early effects of intravenous terbutaline on cardiopulmonary function in chronic obstructive bronchitis and pulmonary hypertension.

    OpenAIRE

    Jones, R. M.; Stockley, R A; Bishop, J M

    1982-01-01

    Terbutaline sulphate (0.25 mg) was given intravenously to 10 recumbent patients with severe irreversible airflow obstruction and pulmonary hypertension who were undergoing right heart catheterisation. Alveolar ventilation index, cardiac index, and mean pulmonary artery pressure all rose significantly at 5 minutes and then fell by 35 minutes, although the first two remained higher than control levels. This was accompanied by a small but significant rise in arterial oxygen tension at 5 minutes....

  6. Chronic bronchitis is an independently associated factor for more symptom and high-risk groups

    OpenAIRE

    Rhee, Chin Kook

    2016-01-01

    Joon Young Choi,1 Hyoung Kyu Yoon,2 Seoung Ju Park,3 Yong Bum Park,4 Kyeong-Cheol Shin,5 Ju Ock Na,6 Kwang Ha Yoo,7 Ki-Suck Jung,8 Young Kyoon Kim,1 Chin Kook Rhee1 1Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St Mary’s Hospital, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yeouido St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, 3Division of Pulmon...

  7. Quantified pathology of emphysema, pneumoconiosis, and chronic bronchitis in coal workers

    OpenAIRE

    Leigh, J; Outhred, K G; McKenzie, H. I.; Glick, M; Wiles, A N

    1983-01-01

    ABSTRACT From a continuous series of 886 postmortem examinations on coal mine workers in New South Wales, Australia, from 1949 to 1982 and their histories the following data were obtained: age at death (886 cases), percentage of emphysema in both lungs (Heard method) (870 cases), bronchial gland wall (G-W) ratio (Reid Index) (412 cases), chest radiograph within 10 years of death (792 cases), history of work at the coal face (844 cases), history of amount of tobacco smoked (606 cases), and FEV...

  8. A liquid phase blocking ELISA for the detection of antibodies against infectious bronchitis virus

    Directory of Open Access Journals (Sweden)

    Cardoso T.C.

    1999-01-01

    Full Text Available A liquid phase blocking ELISA (LPB-ELISA was developed for the detection and measurement of antibodies against infectious bronchitis virus (IBV. The purified and nonpurified virus used as antigen, the capture and detector antibodies, and the chicken hyperimmune sera were prepared and standardized for this purpose. A total of 156 sera from vaccinated and 100 from specific pathogen-free chickens with no recorded contact with the virus were tested. The respective serum titers obtained in the serum neutralization test (SNT were compared with those obtained in the LPB-ELISA. There was a high correlation (r2 = 0.8926 between the two tests. The LPB-ELISA represents a single test suitable for the rapid detection of antibodies against bronchitis virus in chicken sera, with good sensitivity (88%, specificity (100% and agreement (95.31%.

  9. Pathogenicity of virulent infectious bronchitis virus isolate YN on hen ovary and oviduct.

    Science.gov (United States)

    Zhong, Qi; Hu, Yan-Xin; Jin, Ji-Hui; Zhao, Ye; Zhao, Jing; Zhang, Guo-Zhong

    2016-09-25

    Avian infectious bronchitis is an economically important poultry disease caused by avian infectious bronchitis virus (IBV). IBV isolate YN is a virulent strain, which is genetically similar to most of the prevalent strains in China. In this study, 21-day-old commercial laying hens were infected with IBV strain YN. The damaging effects of the virus on the reproductive organs were evaluated with clinical observations, gross autopsy and histopathological examinations during the 100-day monitoring period post infection. IBV strain YN infection caused a death rate of 40.5%. Microscopic lesions were observed on the ovary post-infection, but were restricted to the acute infection period. The pathological damage to the cystic oviducts were observed throughout the surveillance period. This study provides detailed information on the pathological changes in the hen ovary and oviduct after challenge with IBV strain YN, which could provide a better understanding about the pathogenicity of IBV. PMID:27599936

  10. Effects of prednisone on eosinophilic bronchitis in asthma: a systematic review and meta-analysis*,**

    OpenAIRE

    Sakae, Thiago Mamôru; Maurici, Rosemeri; Trevisol, Daisson José; Pizzichini, Marcia Margaret Menezes; Pizzichini, Emílio

    2014-01-01

    OBJECTIVE: To evaluate the effect size of oral corticosteroid treatment on eosinophilic bronchitis in asthma, through systematic review and meta-analysis. METHODS: We systematically reviewed articles in the Medline, Cochrane Controlled Trials Register, EMBASE, and LILACS databases. We selected studies meeting the following criteria: comparing at least two groups or time points (prednisone vs. control, prednisone vs. another drug, or pre- vs. post-treatment with prednisone); and evaluating par...

  11. Effects of prednisone on eosinophilic bronchitis in asthma: a systematic review and meta-analysis,

    OpenAIRE

    Thiago Mamôru Sakae; Rosemeri Maurici; Daisson José Trevisol; Marcia Margaret Menezes Pizzichini; Emílio Pizzichini

    2014-01-01

    OBJECTIVE: To evaluate the effect size of oral corticosteroid treatment on eosinophilic bronchitis in asthma, through systematic review and meta-analysis. METHODS: We systematically reviewed articles in the Medline, Cochrane Controlled Trials Register, EMBASE, and LILACS databases. We selected studies meeting the following criteria: comparing at least two groups or time points (prednisone vs. control, prednisone vs. another drug, or pre- vs. post-treatment with prednisone); and evaluating par...

  12. Comparative evaluation of lung ventilation in patients with dust bronchitis and pneumoconiosis by roentgenopneumopolygraphy

    International Nuclear Information System (INIS)

    The results of roentgenopneumopolygraphy in 290 coal miners are analyzed. Localized diffuse ventilation disorders are detected, that are most pronounced in the upper and central lung regions. In all patients with dust bronchitis local and diffuse emphysematous ventilation disorders were detectable. In all patients with pneumoconiosis combined functional and morphologic changes were found. The use of X-ray function tests in coal miners facilitates an early detection of pathologic lung processes. (author)

  13. Cardiovascular Complications in Chronic Obstructive Pulmonary Disease with Reference to 2D Echocardiography Findings

    Directory of Open Access Journals (Sweden)

    Vikram B Vikhe

    2013-08-01

    Results: Emphysema and chronic bronchitis was present in 38% and 62% respectively. Echocardiographic evidence of cor-pulmonale and pulmonary hypertension was found in 70% of the patients. Conclusions: Echocardiography is more sensitive than electrocardiography in detecting PAH and right ventricular dysfunction in COPD. [Natl J Med Res 2013; 3(4.000: 385-388

  14. A controlled multi-centre study of herbal versus synthetic secretolytic drugs for acute bronchitis.

    Science.gov (United States)

    Ernst, E; März, R; Sieder, C

    1997-12-01

    Herbal expectorants and secretolytic drugs hold a sizeable share of the European market. Therefore it is essential to test their clinical effectiveness and safety. The aim of the present study was to compare the herbal medication Bronchipret(®) with various other pharmacotherapeutical options for acute bronchitis. The study was designed as a matched-pair comparison of 7783 patients. Clinical outcomes of bronchitis and adverse reactions were documented. The data were evaluated by comparing the treatment success of the test medication and 3 control groups using ordinal regression. The results suggest that clinical effectiveness of Bronchipret(®) was not less than with synthetic drugs. There was a tendency for better results with Bronchipret(®), particularly in the treatment of adults. Similar results were obtained with respect to adverse reactions. Particularly in the adult sub-group, these were markedly less with herbals as compared to synthetic drugs. These findings imply that a risk/benefit evaluation would favour Bronchipret(®) over synthetic drugs for acute bronchitis. Their interpretation is limited through the fact that this study could not be randomised nor blinded. The results therefore require confirmation through randomised, double-blind trials.

  15. Evaluation of effectiveness of hydrolyzed dextran in treatment of dust-induced bronchitis

    Energy Technology Data Exchange (ETDEWEB)

    Slinchenko, N.Z.; Filipchenko, L.L.; Volkova, V.M.

    1986-05-01

    An experimental group and a control group identical in age, work experience, dust exposure and expression of disease were treated for dust-induced bronchitis. The control group received broncholytics, anti-inflammatory preparations and physiotherapy; the experimental group received same treatment plus 200 ml of rheopolyglucin, a 10% solution of dextran (water-soluble polysaccharide of glucose), twice a week for 2 to 3 weeks. In addition to general laboratory and clinical methods of investigation, cytologic analysis of sputum before and after treatment was carried out. Results of experiment are given in 3 tables showing: Dynamics of Allergic Signs after Treatment with Rheopolyglucin, Dynamics of Content of Eosinophils in Blood after Treatment, and Cytologic Characteristics of Mucus of Patients with Dust-Induced Bronchitis. Patients treated with rheopolyglucin improved more than control group in abatement of suppurative process in lungs, strengthening of specific cellular and humoral mechanisms of immune response at level of bronchopulmonary system, increased expulsion of mineral dust from lungs and significant reduction of allergic reaction. Results quantitated in tables prove advantages of adding rheopolyglucin to traditional therapy in treatment of dust-induced bronchitis. 19 refs.

  16. Approaching chronic cough

    Science.gov (United States)

    Poulose, Vijo; Tiew, Pei Yee; How, Choon How

    2016-01-01

    Chronic cough is one of the most common reasons for referral to a respiratory physician. Although fatal complications are rare, it may cause considerable distress in the patient’s daily life. Western and local data shows that in patients with a normal chest radiograph, the most common causes are postnasal drip syndrome, postinfectious cough, gastro-oesophageal reflux disease and cough variant asthma. Less common causes are the use of angiotensin-converting enzyme inhibitors, smoker’s cough and nonasthmatic eosinophilic bronchitis. A detailed history-taking and physical examination will provide a diagnosis in most patients, even at the primary care level. Some cases may need further investigations or specialist referral for diagnosis. PMID:26892615

  17. THE EFFECTS OF PRACTICING SWIMMING IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE. CASE STUDY

    OpenAIRE

    Petrescu S.; Ciolan G. A.; Păunescu M.

    2015-01-01

    Chronic obstructive pulmonary disease (COPD) is comprised primarily of two related diseases - chronic bronchitis and emphysema. Clinical research on the effects of swimming on the quality of the life of patients with various lung diseases showed that the use of water therapy programs have significant effects on the induction of pulmonary edema as well as on mild to moderate asthma. The case study presented in this study, aged 52, male, from urban area, smoker (30PA), with a weight of 96 kg an...

  18. Effective use of corticosteroids in treatment of plastic bronchitis with hemoptysis in Chinese adults

    Institute of Scientific and Technical Information of China (English)

    Gang WANG; You-juan WANG; Feng-ming LUO; Lei WANG; Li-li JIANG; Lin WANG; Bing MAO

    2006-01-01

    Aim: To investigate whether corticosteroids are effective in the treatment of plastic bronchitis with hemoptysis. Methods: A retrospective, clinical study was undertaken. Thirty two patients with only first episodes of plastic bronchitis with hemoptysis were divided into a steroid group (n=18) treated with glucocorticoids, and a non-steroid group (n=14). The supportive therapy was uniformly applied to both groups, except for glucocorticoids. Variables such as temperature and white blood cell counts were determined. Furthermore, the volume of hemoptysis and bronchial casts were evaluated in detail daily. Results: There was no difference in the demographic data and variables at baseline between both groups (all P>0.05).On days 5,6,7 and 8, the volume of hemoptysis was significantly decreased in the steroid group compared with the non-steroid group (43±15 mL vs 117±33 mL on d 5,29±12mL vs 97±23mL on d 6,18±10mL vs 80±20mL on d 7,and 13±8mL vs 66±14 mL on d 8; all P<0.05), and on d 10 after fibreoptic bronchoscopy, the cases with bronchial casts was reduced evidently in the steroid group in comparison with the non-steroid group (OR=5.69,95% CI=1.76-43.6; P=0.005). There was no significance in mechanical ventilation and mortality between both groups. Conclusion: Despite some limitations of this study, it has been demonstrated that, on the basis of common supportive therapy, corticosteroids would be effective and safe for the treatment of plastic bronchitis with hemoptysis.

  19. Epidemiological study on circulation of Infectious Bronchitis Virus strains in North Eastern Italy

    Directory of Open Access Journals (Sweden)

    Ilaria Capua

    2010-01-01

    Full Text Available Infectious Bronchitis (IB is still a major health problem in the poultry industry, as it is endemic in probably all countries which raise chickens. Previous investigations have shown that several IB variants are present in the Italian poultry industry. In order to establish which serotypes are circulating in the Veneto and Lombardia regions an investigation was carried out during 2004 in broiler and egg-layer farms. A total of 101 samples were collected from 29 farms with 16 IBV isolations. Of these, seven isolates were identified as being of the IT-02 serotype and six as 793-B on the basis of nucleotide sequencing.

  20. THE USAGE OF HALOAEROSOLOTHERAPY IN THE REHABILITATIONAL TREATMENT OF CHILDREN WITH RECCURENT BRONCHITIS

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    LEMKO Ivan

    2015-05-01

    Full Text Available Aim. Comparative evaluation of the effectiveness of various therapeutic complexes on the basis of haloaerosoltherapy in the rehabilitational treatment of children with recurrent bronchitis on the ground of clinical and functional data and further development of recommendations for differentiated treatment. Objectives. Children (at the age of 6-10 years with recurrent bronchitis, who received treatment in conditions of artificial rock salt aerosol medium (haloaerosoltherapy. Material and Methods. 35 children with recurrent bronchitis (RB were examined. All children’s clinical data were monitored; respiratory function was evaluated using spirography. Forced inspiratory vital capacity (FIVC, forced expiratory volume for the 1-st second (FEV1, peak expiratory flow (PEF, forced expiratory flow at the point of 25% from FIVC(FEF25, forced expiratory flow at the point of 50% from FIVC (FEF50, and forced expiratory flow at the point of 75% from FIVC (FEF75 were defined. The patients were treated with the help of two therapeutic complexes (TC. 12 children were treated by the first TC which included haloaerosoltherapy (14 procedures, in well-equipped room with the initial concentration of rock salt aerosol 40 mg/m3 and the predominance of fine powder fraction (<80%. The first procedure lasted 10 minutes, the second – 20 minutes, the third and the following ones – 30 minutes. The concentration and dispersity of haloaerosol were measured with the help of special laser optical system. 23 children underwent second TC, which included 12 procedures of singlet oxygen therapy in the form of foam additionally to the haloaerosoltherapy sessions. Results. At the beginning of the treatment children had no signs of the acute phase of the disease. Though there were some symptoms which testify that the inflammatory process and functional recovery are not finished yet after the acute phase of the recurrent bronchitis. The clinical picture was confirmed by the major

  1. RNA sequencing based analysis of the spleen transcriptome following the infectious bronchitis virus infection of chickens selected for different mannose-binding lectin serum concentrations

    DEFF Research Database (Denmark)

    Hamzic, Edin; Kjærup, Rikke Brødsgaard; Mach, Núria;

    2016-01-01

    Background Avian infectious bronchitis (IB) is an acute and highly contagious disease of the upper-respiratory tract caused by infectious bronchitis virus (IBV). Understanding the molecular mechanisms involved in the immune response to IBV infection is a crucial element for further improvements i...

  2. RNA sequencing based analysis of the spleen transcriptome following the infectious bronchitis virus infection of chickens selected for different mannose-binding lectin serum concentrations

    DEFF Research Database (Denmark)

    Hamzic, Edin; Kjærup, Rikke Brødsgaard; Mach, Núria;

    2016-01-01

    BackgroundAvian infectious bronchitis (IB) is an acute and highly contagious disease of the upper-respiratory tract caused by infectious bronchitis virus (IBV). Understanding the molecular mechanisms involved in the immune response to IBV infection is a crucial element for further improvements in...

  3. Diagnosis and treatment of chronic cough in China: an insight into the status quo.

    Science.gov (United States)

    Lai, Kefang; Luo, Wei; Zeng, Guangqiao; Zhong, Nanshan

    2012-07-28

    Chronic cough is a very common complaint in clinics throughout China. Clinical and basic science research on chronic cough started late, but in recent years the effort has yielded promising findings regarding the etiological diagnosis, treatment and pathogenesis. We found that inflammation in nonasthmatic eosinophilic bronchitis has some similarities to cough variant asthma but also a number of distinct differences. Recent evidence has also suggested a mechanistic link between airway neurogenic inflammation and and gastroesophageal reflux cough (GERC). Cough-related animal models have been developed, including models for esophageal reflux, nonasthmatic eosinophilic bronchitis and allergic rhinitis. Normal reference values for differential cell counts in induced sputum, cough sensitivity and esophageal 24-h pH monitoring in Chinese healthy subjects have been established. By using a modified algorithm for the etiological diagnosis of chronic cough, the causes of chronic cough have been investigated across a number of cities in China. The most common causes of chronic cough are cough variant asthma, eosinophilic bronchitis, upper airway cough symptoms, atopic cough and GERC, however, there are some regional variations. The Chinese National Guidelines on Diagnosis and Management of Chronic Cough were drafted in 2005, updated in 2009, and have been widely publicized and disseminated through many channels since their publication.

  4. Assessing the economic burden of avian infectious bronchitis on poultry farms in Brazil.

    Science.gov (United States)

    Colvero, L P; Villarreal, L Y B; Torres, C A; Brañdo, P E

    2015-12-01

    Avian infectious bronchitis (IB), caused by avian infectious bronchitis virus (IBV), is a worldwide endemic disease of chickens that affects all branches of the poultry industry. Multiple geno/serotypes occur, and lowvaccine cross-protection results from the highly divergent IBV types. In view of the lack of consistent data on the economic losses caused by IB and the poor protection resulting from the use of the Massachusetts type as a live vaccine in Brazil, this survey aimed to estimate the losses per 1000 birds in broiler and breeder flocks positive for IBV. Thirty-two different IBV genetic types were found. In breeders, the total loss per 1,000 birds was US $3567.4 and US $4210.8 at 25-26 and 42 weeks old, respectively, whereas in broilers (48 days old), the estimated loss was US $266.3 per 1,000 birds. Taken together, the results show a significant and measurable economic impact on the broiler and breeder industries, with an age-dependent increasing trend and an association with multiple genetic types of the virus.

  5. The proteome of the infectious bronchitis virus Beau-R virion.

    Science.gov (United States)

    Dent, Stuart D; Xia, Dong; Wastling, Jonathan M; Neuman, Benjamin W; Britton, Paul; Maier, Helena J

    2015-12-01

    Infectious bronchitis is a highly contagious respiratory disease of poultry caused by the coronavirus infectious bronchitis virus (IBV). It was thought that coronavirus virions were composed of three major viral structural proteins until investigations of other coronaviruses showed that the virions also include viral non-structural and genus-specific accessory proteins as well as host-cell proteins. To study the proteome of IBV virions, virus was grown in embryonated chicken eggs, purified by sucrose-gradient ultracentrifugation and analysed by mass spectrometry. Analysis of three preparations of purified IBV yielded the three expected structural proteins plus 35 additional virion-associated host proteins. The virion-associated host proteins had a diverse range of functional attributions, being involved in cytoskeleton formation, RNA binding and protein folding pathways. Some of these proteins were unique to this study, while others were found to be orthologous to proteins identified in severe acute respiratory syndrome coronavirus virions and also virions from a number of other RNA and DNA viruses. PMID:27257648

  6. Immune Responses to Virulent and Vaccine Strains of Infectious Bronchitis Viruses in Chickens.

    Science.gov (United States)

    Chhabra, Rajesh; Chantrey, Julian; Ganapathy, Kannan

    2015-11-01

    Infectious bronchitis (IB) is an acute and highly contagious chicken viral disease, causing severe economic losses to poultry producers worldwide. In the last few decades, infectious bronchitis virus (IBV) has been extensively studied, but knowledge of immune responses to virulent or vaccine strains of IBVs remains limited. This review focuses on fundamental aspects of immune responses against IBV, including the role of pattern recognition receptors (PRRs) in identification of conserved viral structures and the role of different components of innate immunity (e.g., heterophils, macrophages, dendritic cells, acute phase protein, and cytokines). Studies on adaptive immune activation and the role of humoral and cellular immunity in IBV clearance are also reviewed. Multiple interlinking immune responses are essential for protection against virulent IBVs, including passive, innate, adaptive, and effector T cells active at mucosal surfaces. Although the development of approaches for chicken transcriptome and proteome analyses have greatly helped the understanding of the underlying genetic mechanisms for immunity, there are still major knowledge gaps, such as the role of mucosal and cellular responses to IBVs. In view of recent reports of emergent IBV variants in many countries, there is renewed interest in a more complete understanding of poultry immune responses to both virulent and vaccine strains of IBVs. This will be critical for developing new vaccine or vaccination strategies and other intervention programs. PMID:26301315

  7. Adaptation of infectious bronchitis virus in primary cells of the chick embryo chorioallantoic membrane

    Directory of Open Access Journals (Sweden)

    M. H. Mohammed

    2013-06-01

    Full Text Available The susceptibility of the primary chick embryo chorioallontoic membrane cells to infectious bronchitis virus was evaluated after twenty consecutive passages in chick embryo chorioallontoic membrane cells. Virus replication was monitored by cytopathic observation, indirect immunoperoxidase, and reverse transcription polymerase chain reaction (RT-PCR. At 72 hours post-infection (p.i. in third passage, the cytopathic effect was characterized by rounding up of cells, monolayer detachment, intracytoplasmic brownish colouration was readily observed by immunoperoxidase from 24 hours p.i in third passage, and at all times the extracted viral RNA from IBV-infected monolayers was demonstrated by RT-PCR. Tissue culture ineffective dose50 (TCID50 was used to measure virus titration performed on primary chick embryo chorioallontoic membrane cells and the titre in twenty passage was 108.6 TCID50/ml. The results obtained in this study suggested that the primary chick embryo chorioallontoic membrane cells can be used for adaptation infectious bronchitis virus (IBV and may be considered a step forward for the use of these cells in the future for IBV vaccine production

  8. Studies on Molecular Variant Mechanism of Infectious Bronchitis Viruses of Beijing Area

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Using reverse transcription-nested Polymerase Chain Reaction(RT-nested PCR), the S1 gene hypervariable regions of Avian Infectious Bronchitis Viruses(IBV) strains BJ1, BJ2, BJ3, isolated from Beijing areas, were amplified successfully. The region consists of 1054 bp of 5'-end of S1 gene which were regarded as the most variable region among IBV strains. Sequences of the S1 gene were determined from recombinant plasmids by using the dideoxy sequencing technique in two directions. Comparing three isolates with standard strains M41, Beaudette, vaccine strain H120 and one isolated strain D41 from Guangdong province, it was shown they were more homology in nucleotide sequence and deduced amino acid sequence with M41 than Beaudette and H120. However, secondary structure of their encoding proteins are more similar with H120 than M41 and Beaudette strains. All of these indicate there are complex relationship among difference of nucleotide sequence, changes of virus determinants and serotypes in Infectious Bronchitis Virus.

  9. Molecular characterization of infectious bronchitis viruses isolated from broiler chicken farms in Iran, 2014-2015.

    Science.gov (United States)

    Najafi, Hamideh; Langeroudi, Arash Ghalyanchi; Hashemzadeh, Masoud; Karimi, Vahid; Madadgar, Omid; Ghafouri, Seyed Ali; Maghsoudlo, Hossein; Farahani, Reza Khaltabadi

    2016-01-01

    Infectious bronchitis (IB) is a viral avian disease with economic importance in the world, including Iran. S1 gene sequencing has been used for molecular epidemiological studies and genotypic characterization of infectious bronchitis virus (IBV). A total of 118 IBV isolates were obtained from tissue samples from chickens with clinically suspected IB from Iranian broiler farms (eight provinces, 200 samples). The isolates were confirmed by real-time polymerase chain reaction (PCR) and characterized by sequencing the spike glycoprotein gene. The isolates formed six distinct phylogenetic groups (IS/1494/06 [Var2] like, 4/91-like, IS/720-like, QX-like, IR-1 and Mass-like) that were related to variants isolated in the region. The most frequently detected viruses were of the Var2-like (IS/1494/06-like) genotype, with an overall prevalence of 34 %. Twenty-one percent of the isolates formed a cluster together with the 4/91 IBV type, 10 % were of the QX genotype, and 8 % were of the IS/720 genotype. In addition, 4 % and 3 % of the isolates belonged to the Massachusetts and IR-1 genotype, respectively. For the first time, we have isolated and characterized IBV variants from broiler farms in different provinces of Iran. This study demonstrates a constant evolution of IBV in Iran, demonstrating the need for continuous monitoring and development of new vaccines based on indigenous viruses.

  10. Infectious bronchitis virus and brown shell colour: Australian strains of infectious bronchitis virus affect brown eggshell colour in commercial laying hens differently.

    Science.gov (United States)

    Samiullah, Sami; Roberts, Juliet; Chousalkar, Kapil

    2016-10-01

    The aim of the current study was to assess any effect of wild and vaccine Australian infectious bronchitis virus (IBV) strains on shell colour in brown-shelled eggs. In Experiment 1, eggs were collected from day 1 to day 13 post-inoculation (p.i.) from unvaccinated laying hens challenged with IBV wild strains T and N1/88 and from a negative control group of hens. In Experiment 2, eggs were collected from 2 to 22 days p.i. from unvaccinated and vaccinated laying hens challenged with either a wild or a vaccine strain of IBV. In Experiment 1, there was a significant effect (P shell reflectivity, L* and protoporphyrin IX (PP IX) in eggshells, with and without cuticle. The mean PP IX/g of shell with and without cuticle was significantly higher on day 1 p.i. compared to day 7, after which PP IX increased with day p.i. In Experiment 2, shell reflectivity and L* increased and PP IX decreased with increased day p.i. until day 12. Shell reflectivity and L* decreased slightly after day 12 and increased again towards day 22. Shell reflectivity, L* and PP IX were not significantly different for eggshells from unvaccinated and vaccinated laying hens in the intact eggshell, but were significantly different in shells from which cuticle had been removed. In conclusion, the IBV strains reduced the intensity of brown shell colour to different extents with a lower amount of PP IX in eggshells.

  11. Treatment of 301 Infantile Acute Bronchitis Patients withQingre Lifei (清热利肺) Oral Liquid

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    From December 1995 to May 1996, 4 hospitals in Beijing, Guangzhou and Chengdu had 301 patients with infantile acute bronchitis (IAB) treated with Qingre Lifei (清热利肺, QRLF) oral liquid and the results compared with that of similar cases treated with Shema (射麻, SM) oral liquid. Following is the report.

  12. Epitopes on the peplomer protein of infectious bronchitis virus strain M41 as defined by monoclonal antibodies.

    NARCIS (Netherlands)

    N.M.C. Bleumink-Pluym; A.D.M.E. Osterhaus (Ab); M.C. Horzinek; B.A.M. van der Zeijst (Ben); H.G.M. Niesters (Bert)

    1987-01-01

    textabstractSixteen monoclonal antibodies (Mcabs) were prepared against infectious bronchitis virus strain M41, all of them reacting with the peplomer protein. One of them, Mcab 13, was able to neutralize the virus and to inhibit hemagglutination. Competition binding assays allowed the definition of

  13. A STUDY OF CLINICAL, RADIOLOGICAL, PULMONARY FUNCTIONS IN PATIENTS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

    Directory of Open Access Journals (Sweden)

    Vishnukanth

    2014-06-01

    Full Text Available Respiratory diseases impose a tremendous health burden on society. As countries industrialize, rising pollution and changes in lifestyle have contributed to increased levels of respiratory disease. Chronic obstructive pulmonary disease (COPD refers to a group of disorders characterized by chronic airflow obstruction/limitation. The airway obstruction is persistent and largely irreversible. WHO defines COPD as encompassing two groups of lung diseases, chronic bronchitis and emphysema. The present universally accepted guidelines no longer divide COPD into chronic bronchitis or emphysema as there is not much difference with regard to treatment protocols. AIM: The present study is being undertaken to evaluate the clinical, radiological and pulmonary functions in patients of COPD. An attempt also has been made to classify patients of COPD into chronic bronchitis and emphysema. A total of 153 patients were screened and inclusion and exclusion criteria applied. Forty patients were evaluated clinically, radiologically and pulmonary functions including diffusion studies were done. They were phenotypically divided into emphysema predominant and chronic bronchitis predominant. Breathlessness as assessed by MMRC grade and pulmonary functions were equal in both the groups. There was no radiological and phenotypical correlation. CONCLUSION: There is no significant difference in the severity of airflow obstruction as measured by FEV1 between the two phenotypes of COPD (Fisher’s exact test, P>0.05. There is a significant overlapping of symptoms, radiological findings and pulmonary functions among the phenotypes of COPD. Hence it can be reasonably concluded that it is difficult to make a diagnosis of COPD phenotypes based on clinical, radiological, spirometry and DLCo parameters

  14. Association of residential dampness and mold with respiratory tract infections and bronchitis: a meta-analysis

    Energy Technology Data Exchange (ETDEWEB)

    Fisk, William J.; Eliseeva, Ekaterina A.; Mendell, Mark J.

    2010-11-15

    Dampness and mold have been shown in qualitative reviews to be associated with a variety of adverse respiratory health effects, including respiratory tract infections. Several published meta-analyses have provided quantitative summaries for some of these associations, but not for respiratory infections. Demonstrating a causal relationship between dampness-related agents, which are preventable exposures, and respiratory tract infections would suggest important new public health strategies. We report the results of quantitative meta-analyses of published studies that examined the association of dampness or mold in homes with respiratory infections and bronchitis. For primary studies meeting eligibility criteria, we transformed reported odds ratios (ORs) and confidence intervals (CIs) to the log scale. Both fixed and random effects models were applied to the log ORs and their variances. Most studies contained multiple estimated ORs. Models accounted for the correlation between multiple results within the studies analyzed. One set of analyses was performed with all eligible studies, and another set restricted to studies that controlled for age, gender, smoking, and socioeconomic status. Subgroups of studies were assessed to explore heterogeneity. Funnel plots were used to assess publication bias. The resulting summary estimates of ORs from random effects models based on all studies ranged from 1.38 to 1.50, with 95% CIs excluding the null in all cases. Use of different analysis models and restricting analyses based on control of multiple confounding variables changed findings only slightly. ORs (95% CIs) from random effects models using studies adjusting for major confounding variables were, for bronchitis, 1.45 (1.32-1.59); for respiratory infections, 1.44 (1.31-1.59); for respiratory infections excluding nonspecific upper respiratory infections, 1.50 (1.32-1.70), and for respiratory infections in children or infants, 1.48 (1.33-1.65). Little effect of publication

  15. Chronic pancreatitis

    Science.gov (United States)

    Chronic pancreatitis - chronic; Pancreatitis - chronic - discharge; Pancreatic insufficiency - chronic; Acute pancreatitis - chronic ... abuse over many years. Repeated episodes of acute pancreatitis can lead to chronic pancreatitis. Genetics may be ...

  16. Heparan sulfate is a selective attachment factor for the avian coronavirus infectious bronchitis virus Beaudette.

    Science.gov (United States)

    Madu, Ikenna G; Chu, Victor C; Lee, Hwajin; Regan, Andrew D; Bauman, Beverley E; Whittaker, Gary R

    2007-03-01

    The avian coronavirus infectious bronchitis virus (IBV) strain Beaudette is an embryo-adapted virus that has extended species tropism in cell culture. In order to understand the acquired tropism of the Beaudette strain, we compared the S protein sequences of several IBV strains. The Beaudette strain was found to contain a putative heparan sulfate (HS)-binding site, indicating that the Beaudette virus may use HS as a selective receptor. To ascertain the requirements of cell-surface HS for Beaudette infectivity, we assayed for infectivity in the presence of soluble heparin as a competitor and determined infectivity in mutant cell lines with no HS or glycosaminoglycan expression. Our results indicate that HS plays a role as an attachment factor for IBV, working in concert with other factors like sialic acid to mediate virus binding to cells, and may explain in part the extended tropism of IBV Beaudette.

  17. Detection of variant infectious bronchitis viruses in Sri Lanka (2012-2015).

    Science.gov (United States)

    Ball, Christopher; Forrester, Anne; Ganapathy, Kannan

    2016-06-01

    Poultry production is an important sector of agriculture in Sri Lanka; however, there is a lack of information regarding circulation of infectious bronchitis virus (IBV). RNA was extracted from chicken tissues, subjected to IBV S1 RT-PCR, and sequenced. Overall, 19 out of 34 (55.88 %) samples were IBV positive and contained the genotype 793B (n = 13; 68.42 %), D274 (n = 4; 21.05 %) or Massachusetts (n = 2; 10.53 %). All three genotypes contained at least one strain with less than 99 % nucleotide sequence identity to the corresponding vaccine strains. This report identified co-circulation of IBV strains 793B, Massachusetts and D274, in Sri Lanka that are divergent from the respective vaccine strains. PMID:27020570

  18. Effects of prednisone on eosinophilic bronchitis in asthma: a systematic review and meta-analysis,

    Directory of Open Access Journals (Sweden)

    Thiago Mamôru Sakae

    2014-10-01

    Full Text Available OBJECTIVE: To evaluate the effect size of oral corticosteroid treatment on eosinophilic bronchitis in asthma, through systematic review and meta-analysis. METHODS: We systematically reviewed articles in the Medline, Cochrane Controlled Trials Register, EMBASE, and LILACS databases. We selected studies meeting the following criteria: comparing at least two groups or time points (prednisone vs. control, prednisone vs. another drug, or pre- vs. post-treatment with prednisone; and evaluating parameters before and after prednisone use, including values for sputum eosinophils, sputum eosinophil cationic protein (ECP, and sputum IL-5-with or without values for post-bronchodilator FEV1-with corresponding 95% CIs or with sufficient data for calculation. The independent variables were the use, dose, and duration of prednisone treatment. The outcomes evaluated were sputum eosinophils, IL-5, and ECP, as well as post-bronchodilator FEV1. RESULTS: The pooled analysis of the pre- vs. post-treatment data revealed a significant mean reduction in sputum eosinophils (↓8.18%; 95% CI: 7.69-8.67; p < 0.001, sputum IL-5 (↓83.64 pg/mL; 95% CI: 52.45-114.83; p < 0.001, and sputum ECP (↓267.60 µg/L; 95% CI: 244.57-290.63; p < 0.0001, as well as a significant mean increase in post-bronchodilator FEV1 (↑8.09%; 95% CI: 5.35-10.83; p < 0.001. CONCLUSIONS: In patients with moderate-to-severe eosinophilic bronchitis, treatment with prednisone caused a significant reduction in sputum eosinophil counts, as well as in the sputum levels of IL-5 and ECP. This reduction in the inflammatory response was accompanied by a significant increase in post-bronchodilator FEV1.

  19. Genome sequencing and characterization analysis of a Beijing isolate of chicken corona virus infectious bronchitis virus

    Institute of Scientific and Technical Information of China (English)

    JIN Weiwu; YU Jialin; LI Ning; GONG Yuanshi; SUN Qixin; CHEN Zhangliang; CHEN Chen; ZHANG Ying; ZHAO Yiqiang; FENG Jidong; CHEN Fuyong; WU Qingming; YANG Hanchun; WANG Ming

    2004-01-01

    Avian infectious bronchitis virus (AIBV) is lassified as a member of the genus coronavirus in the family coronaviridae. The enveloped virus has a positive-sense, single-stranded RNA genome of approximately 28 kilo-bases,which has a 5′ cap structure and 3′ polyadenylation tract.The complete genome sequence of infectious bronchitis virus (IBV), Beijing isolate, was determined by cloning sequencing and primer walking. The whole genome is 27733 nucleotides in length, has ten open reading frames: 5′-orfla-orflab-s-3a-3b-e-m- 6a-6b-n-3′. Alignments of the genome sequence of IBV Beijing isolate with those of two AIBV strains and one SARS coronavirus were performed respectively. The genome sequence of IBV Beijing isolate compared with that of the IBV strain LX4 (uncompleted, 19440 bp in size) was 91.2%similarity. However, the full-length genome sequence of IBV Beijing isolate was 85.2% identity to that of IBV Strain Beaudette, and was only 50.8% homology to that of SARS coronavirus. The results showed that the genome of IBV has remarkable variation. And IBV Beijing isolate is not closely related to SARS coronavirus. Phylogenetic analyses based on the whole genome sequence, S protein, M protein and N protein, also showed that AIBV Beijing isolate is lone virus in group Ⅲ and is distant from SARS coronavirus. In conclusion, this study will contribute to the studies of diagnosis and diseases control on IBV in China.

  20. S1 gene sequence analysis of a nephropathogenic strain of avian infectious bronchitis virus in Egypt

    Directory of Open Access Journals (Sweden)

    Ladman Brian S

    2006-09-01

    Full Text Available Abstract Background Infectious bronchitis is highly contagious and constitutes one of the most common and difficult poultry diseases to control. IBV is endemic in probably all countries that raise chickens. It exists as dozens of serotypes/genotypes. Only a few amino acid differences in the S1 protein of vaccine and challenge strains of IBV may result in poor protection. Tropism of IBV includes the respiratory tract tissues, proventriculus and caecal tonsils of the alimentary tract, the oviduct and the kidney. Results Infectious bronchitis virus (IBV strain closely related to Massachusetts (Mass serotype was isolated from broiler chickens suffering from severe renal and respiratory distresses. The isolate was serologically identified by Dot-ELISA and further characterized by RT-PCR then genotyped using S1 gene sequence analysis. Alignment of the S1 sequence of the isolate with 16 IBV strains revealed high homology to isolates related to Mass serotype. Inoculation with the strain reproduced the disease in experimental 1-day-old chickens and resulted in 20% mortality, severe renal and moderate respiratory distresses. Marked histopathological changes in both kidney and trachea were observed in experimentally infected chickens. A protection study using the H120 live attenuated vaccine showed low protection rate in spite of high S1 sequence homology (97%. Protection based criteria were: virus re-isolation attempts from trachea, tracheal and renal histopathology as well as IBV antigens detection by immunofluorescent antibody technique in kidney sections. Conclusion Periodical evaluation of cross-protective capabilities of IBV vaccine(s versus recently recovered field isolates should be performed to ensure optimum control of IBV.

  1. Serotype variation among infectious bronchitis viral isolates taken from several areas of Java

    Directory of Open Access Journals (Sweden)

    Risa Indriani

    2000-12-01

    Full Text Available Infectious bronchitis (IB is an acute highly contagious viral respiratory disease of poultry caused by virus belongs to the family of Coronaviridae. The virus consist of many serotypes with low level of cross-protectivity among serotypes. Field data showed that the outbreaks of IB were frequently reported in chicken flocks, although vaccinations against the disease have been practiced. Hence, the study on serotype relationship among isolates of the viruses is essentially required. The aim of this study was to isolate and characterize IB viruses from chicken flocks in some areas of Java. Isolation of the virus was carried out in nine-day old embrionated chicken eggs and identified by means of agar gel precipitation (AGP tests against standard antisera to IB virus. The serotypes of the IB viral isolates were determined by cross-neutralization tests in nine day old embryonated chicken eggs using r value derived from homologous and heterologous serum titres as criteria. This study obtained 12 IB viral isolates which were identified on the basis of the ability to cause lesions in chicken embryos and positive to agar gel presipitation test against standard positive antiserum to the virus. Based on the cross-neutralization tests in embryonated chicken eggs, isolate I.9 was formed to have relationship closed to Mass-41 serotype, while I.2, I. 3, and I.7 isolates were closely to the serotype of Con-46. Virus isolates (I.5, I.14, I.24, and I.25 were decided to have no serotype relationships to either Mass-41 or Con-46 serotype. Since the I.5, I.14, I.24 and I.25 isolates were not neutralized by antisera against the previous identified local infectious bronchitis viral isolates, and that were considered to be distinct serotype to the previously identified local IB viral isolates.

  2. Feline aminopeptidase N is not a functional receptor for avian infectious bronchitis virus

    Directory of Open Access Journals (Sweden)

    Harbison Carole E

    2007-02-01

    Full Text Available Abstract Background Coronaviruses are an important cause of infectious diseases in humans, including severe acute respiratory syndrome (SARS, and have the continued potential for emergence from animal species. A major factor in the host range of a coronavirus is its receptor utilization on host cells. In many cases, coronavirus-receptor interactions are well understood. However, a notable exception is the receptor utilization by group 3 coronaviruses, including avian infectious bronchitis virus (IBV. Feline aminopeptidase N (fAPN serves as a functional receptor for most group 1 coronaviruses including feline infectious peritonitis virus (FIPV, canine coronavirus, transmissible gastroenteritis virus (TGEV, and human coronavirus 229E (HCoV-229E. A recent report has also suggested a role for fAPN during IBV entry (Miguel B, Pharr GT, Wang C: The role of feline aminopeptidase N as a receptor for infectious bronchitis virus. Brief review. Arch Virol 2002, 147:2047–2056. Results Here we show that, whereas both transient transfection and constitutive expression of fAPN on BHK-21 cells can rescue FIPV and TGEV infection in non-permissive BHK cells, fAPN expression does not rescue infection by the prototype IBV strain Mass41. To account for the previous suggestion that fAPN could serve as an IBV receptor, we show that feline cells can be infected with the prototype strain of IBV (Mass 41, but with low susceptibility compared to primary chick kidney cells. We also show that BHK-21 cells are slightly susceptible to certain IBV strains, including Ark99, Ark_DPI, CA99, and Iowa97 ( Conclusion We conclude that fAPN is not a functional receptor for IBV, the identity of which is currently under investigation.

  3. Treatment of Cough and Dyspnea due to Acute Bronchitis by Plaster for Cough and Dyspnea-A Report of 735 Cases

    Institute of Scientific and Technical Information of China (English)

    陈振甫; 周文秀; 高举先; 孙江桥

    2002-01-01

    @@ In the light of the theory of treating the internal disease externally, an externally used plaster for treating cough and dyspnea due to acute bronchitis (Ke Chuan Yi Tie Kang 咳喘一贴康) was successfully applied to 735 cases of acute bronchitis (the treatment group), with the other 423 cases treated with routine western drugs as controls. The results showed that the cure rate in the treatment group was significantly higher than that in the control group (P<0.01); and that in the treatment group, the cure rate for the wind-cold type of acute bronchitis was significantly higher than that for the wind-heat type of acute bronchitis (P<0.01).

  4. Chronic Diarrhea

    Science.gov (United States)

    ... infections that cause chronic diarrhea be prevented? Chronic Diarrhea What is chronic diarrhea? Diarrhea that lasts for more than 2-4 ... represent a life-threatening illness. What causes chronic diarrhea? Chronic diarrhea has many different causes; these causes ...

  5. Proteomic analysis of chicken embryonic trachea and kidney tissues after infection in ovo by avian infectious bronchitis coronavirus

    OpenAIRE

    Cao, Zhongzan; Han, Zongxi; Shao, Yuhao; Geng, Heyuan; Kong, Xiangang; Liu, Shengwang

    2011-01-01

    Background Avian infectious bronchitis (IB) is one of the most serious diseases of economic importance in chickens; it is caused by the avian infectious coronavirus (IBV). Information remains limited about the comparative protein expression profiles of chicken embryonic tissues in response to IBV infection in ovo. In this study, we analyzed the changes of protein expression in trachea and kidney tissues from chicken embryos, following IBV infection in ovo, using two-dimensional gel electropho...

  6. Role of Atypical Pathogens and the Antibiotic Prescription Pattern in Acute Bronchitis: A Multicenter Study in Korea.

    Science.gov (United States)

    Park, Sunghoon; Oh, Kil Chan; Kim, Ki-Seong; Song, Kyu-Tae; Yoo, Kwang Ha; Shim, Yun Su; Lee, Young Ju; Lee, Myung Goo; Yun, Jang Uk; Kim, Hyun Su; Kim, Yee Hyung; Lee, Won Jun; Kim, Do Il; Cha, Hyung Gun; Lee, Jae-Myung; Seo, Jung San; Jung, Ki-Suck

    2015-10-01

    The role of atypical bacteria and the effect of antibiotic treatments in acute bronchitis are still not clear. This study was conducted at 22 hospitals (17 primary care clinics and 5 university hospitals) in Korea. Outpatients (aged ≥ 18 yr) who had an acute illness with a new cough and sputum (≤ 30 days) were enrolled in 2013. Multiplex real-time polymerase chain reaction (RT-PCR) was used to detect five atypical bacteria. A total of 435 patients were diagnosed as having acute bronchitis (vs. probable pneumonia, n = 75), and 1.8% (n = 8) were positive for atypical pathogens (Bordetella pertussis, n = 3; B. parapertussis, n = 0; Mycoplasma pneumoniae, n = 1; Chlamydophila pneumoniae, n = 3; Legionella pneumophila, n = 1). Among clinical symptoms and signs, only post-tussive vomiting was more frequent in patients with atypical pathogens than those without (P = 0.024). In all, 72.2% of the enrolled patients received antibiotic treatment at their first visits, and β-lactams (29.4%) and quinolones (20.5%) were the most commonly prescribed agents. In conclusion, our study demonstrates that the incidence of atypical pathogens is low in patients with acute bronchitis, and the rate of antibiotic prescriptions is high. PMID:26425041

  7. CLINICAL OBSERVATION ON TREATMENT OF ACUTE BRONCHITIS PRIMARILY WITH PRICKING-CUPPING ON BACK-SHU POINTS

    Institute of Scientific and Technical Information of China (English)

    XU Wei-dong; ZHANG Yong-juan; YANG Jie; CHEN Xiao-xiang; LIU Yong-xiang

    2006-01-01

    Objective: To observe the clinical effect of treatment of acute bronchitis primarily with prickingcupping method on Back-shu points. Methods: The patients of acute bronchitis were randomly divided into 2groups. In the observation group, there were 36 cases, who were treated with the integrated traditional Chinese and western medicine, primarily the pricking-cupping method on Back-shu points; while in the control group, there were 29 cases who were given the conventinal treatment of western medicine. All the 2 groups were treated for 7 days as one treating course. Results: The total effective rate of the observation group was 97.2% while that of the control group was 82.8%, so there is a significant difference between them. On the first and third days the clinical manifestations were more satisfactorily improved in the treatment group than in the control group (P < 0.01 ) and on the fifth and seventh days, the comparison showed no significant difference (P >0.05). Conclusion: The treatment of acute bronchitis by means of the integrated traditional Chinese and western medicine primarily with pricking-cupping method on Back-shu points is of marked therapeutic effect, simple manipulation, and little untoward effects, thus claiming the unique advantage.

  8. Natural histories of chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Rennard, Stephen I; Vestbo, Jørgen

    2008-01-01

    English men over 8 years, was used to construct a proposed life-long natural history. Although this is a classic study that has greatly advanced understanding of COPD, it has a number of limitations. Its duration is relatively short compared with the duration of COPD, so it is more cross-sectional than......Concepts relating to the natural history of chronic obstructive pulmonary disease (COPD) arise most importantly from the classic study of Fletcher and colleagues (The Natural History of Chronic Bronchitis and Emphysema, Oxford University Press, New York, 1976). This study, which evaluated working...... longitudinal. It was unable to distinguish among varied "natural histories." It assessed primarily the FEV(1), and the natural history of other features of COPD is largely undescribed. With advances in understanding the clinical features of COPD and with the development of evaluating new tools to assess...

  9. Interpretation of bronchodilator response in patients with obstructive airways disease. The Dutch Chronic Non-Specific Lung Disease (CNSLD) Study Group.

    OpenAIRE

    Brand, P L; Quanjer, P. H.; Postma, D. S.; Kerstjens, H.A.; Koëter, G. H.; Dekhuijzen, P. N.; Sluiter, H J

    1992-01-01

    BACKGROUND: There is no agreement on how a bronchodilator response should be expressed. Ideally, the index used should be able to distinguish asthma from chronic obstructive lung disease and be independent of initial FEV1. METHODS: Two hundred and seventy four adults (aged 18-60 years) outpatients with obstructive airways disease were studied. Patients were divided into syndrome groups on the basis of a standardised history: asthma (n = 99), asthmatic bronchitis (n = 88), and chronic obstruct...

  10. Cefditoren versus levofloxacin in patients with exacerbations of chronic bronchitis: serum inflammatory biomarkers, clinical efficacy, and microbiological eradication

    OpenAIRE

    Blasi F; Tarsia P; Mantero M; Morlacchi LC; Piffer F

    2013-01-01

    Francesco Blasi, Paolo Tarsia, Marco Mantero, Letizia C Morlacchi, Federico PifferDepartment of Pathophysiology and Transplantation, University of Milan, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Milan, ItalyBackground: The aim of this open-label, randomized, parallel-group pilot study was to evaluate the efficacy of cefditoren pivoxil and levofloxacin in terms of speed of reduction in inflammatory parameters, clinical recovery, and microbiological eradication.Metho...

  11. Clinical effectiveness and safety of gemifloxacin versus cefpodoxime in acute exacerbation of chronic bronchitis: A randomized, controlled trial

    Directory of Open Access Journals (Sweden)

    S Chatterjee

    2011-01-01

    Conclusion : The results of this randomized, single-blind trial demonstrated that a 7-day course of gemifloxacin is therapeutically comparable to cefpodoxime in terms of both clinical effectiveness and safety for the treatment of type II Anthonisen category AECB patients.

  12. Annexin A2 binds RNA and reduces the frameshifting efficiency of infectious bronchitis virus.

    Directory of Open Access Journals (Sweden)

    Hoyun Kwak

    Full Text Available Annexin A2 (ANXA2 is a protein implicated in diverse cellular functions, including exocytosis, DNA synthesis and cell proliferation. It was recently proposed to be involved in RNA metabolism because it was shown to associate with some cellular mRNA. Here, we identified ANXA2 as a RNA binding protein (RBP that binds IBV (Infectious Bronchitis Virus pseudoknot RNA. We first confirmed the binding of ANXA2 to IBV pseudoknot RNA by ultraviolet crosslinking and showed its binding to RNA pseudoknot with ANXA2 protein in vitro and in the cells. Since the RNA pseudoknot located in the frameshifting region of IBV was used as bait for cellular RBPs, we tested whether ANXA2 could regulate the frameshfting of IBV pseudoknot RNA by dual luciferase assay. Overexpression of ANXA2 significantly reduced the frameshifting efficiency from IBV pseudoknot RNA and knockdown of the protein strikingly increased the frameshifting efficiency. The results suggest that ANXA2 is a cellular RBP that can modulate the frameshifting efficiency of viral RNA, enabling it to act as an anti-viral cellular protein, and hinting at roles in RNA metabolism for other cellular mRNAs.

  13. Diagnostic and clinical observation on the infectious bronchitis virus strain Q1 in Italy

    Directory of Open Access Journals (Sweden)

    Anna Toffan

    2013-12-01

    Full Text Available This paper describes the diagnostic and clinical observations of an infectious bronchitis virus (IBV variant, referred to as Q1, in clinically ill chickens in Italy. This IBV variant was described for the first time in 1998 in China. In the autumn of 2011 it caused a small-scale epidemic in non-vaccinated meat chickens in farms located in Northern Italy. The disease was characterized by increased mortality, kidney lesions and proventriculitis. Histopatological observations confirmed the nephritis and described an unusual erosive/necrotic proventriculitis with infiltration of lymphocytes, plasma cells and heterophils, as well as fibroplasia in the lamina propria. Despite these findings and the isolation of the Q1 IB virus directly from proventricular tissue, further studies are necessary to confirm the role of this IBV strain in the development of proventricular lesions. Phylogenetic analysis revealed that all the IBV isolates were very similar and probably had a common origin. The IBV Q1 variant appears to be now endemic in the North of Italy and at times it is detected in vaccinated backyard and commercial broiler farms. The importance of continuous monitoring in controlling the spread of known or emerging IBV variants is underlined.

  14. TRYPSIN-INDUCED HEMAGGLUTINATION ASSAY FOR THE DETECTION OF INFECTIOUS BRONCHITIS VIRUS

    Directory of Open Access Journals (Sweden)

    M. S. Mahmood, M. Siddique, I. Hussain and A. Khan1

    2004-04-01

    Full Text Available A trypsin-induced hemagglutination (THA assay was standardized to detect infectious bronchitis virus (IBV in allantoic fluid (AF of embryonated eggs. The test was used in 20 samples, each collected from 5 different layer farms suspected for IBV. Allantoic fluid from inoculated embryos was harvested and treated with reagent grade trypsin at the percentages of 0.25, 0.50, 1.0 and 2.0 for 30 minutes to 3 hours at pH 7.2. The IBV in trypsinized AF was identified by clear and consistent agglutination of chicken red blood cells within 5 minutes of incubation at 37oC. The results indicated that AF treated with equal volume of 1.0% reagent grade trypsin elicited the hemagglutinating (HA activity in 3.0 hours whereas 2.0% reagent grade trypsin elicited the HA activity only after 30 minutes incubation at 37oC. Sensitivity of THA was 92% as compared with 76% for agar gel precipitation test. Gross pathological lesions (curling and dwarfing in chick embryo, intracereberal inoculation of un-weaned mice and pathogenicity test in one-day-old broiler chicks showed 79, 84 and 77% sensitivity, respectively.

  15. Molecular Characteristics of S1 Gene of Infectious Bronchitis Virus Isolated from Chicken Proventriculus

    Institute of Scientific and Technical Information of China (English)

    CHENG Li-qin; ZHOU Ji-yong; John Dikki; SHEN Xing-yan; CHEN Ji-gang; ZHANG De-yong

    2003-01-01

    Infectious bronchitis virus was isolated from swollen proventriculi of clinically ill chicken. Thesuspected virus samples (2/97, 3/97, 1/98) were adapted in SPF chicken embryos for virus isolation andidentification. All the virus isolates were able to agglutinate chicken erythrocytes after treatment with trypsin,and interfer with the reproduction of Newcastle disease virus in chicken embryos, and have low antigenic relat-edness values with reference positive IBV. The isolates 2/97, 3/97, 1/98 RNAs extracted from the allantoicfluid of inoculated embryonated eggs were converted to cDNA by reverse transcription with 3'-primer of S1gene of (IBV). Polymerase chain reaction (PCR) was performed with two primers which span the S1 gene.Amplified product of 1.93 kb was subjected to EcoR Ⅰ and BamH Ⅰ digestion and the fragments obtainedwere the same as expected size. The PCR product was ligated to pBlueScript-SK (+) vector, and its nucleotidesequence was determined by the dideoxy-mediated chain termination method. Nucleotide sequence analysisshowed 73.6 - 99.7 % homology between the isolated IBV and the IBV strains in GenBank. The homology ofamino acid was 71.4 - 99.4 %.

  16. Complete genomic sequence analysis of infectious bronchitis virus Ark DPI strain and its evolution by recombination.

    Science.gov (United States)

    Ammayappan, Arun; Upadhyay, Chitra; Gelb, Jack; Vakharia, Vikram N

    2008-12-22

    An infectious bronchitis virus Arkansas DPI (Ark DPI) virulent strain was sequenced, analyzed and compared with many different IBV strains and coronaviruses. The genome of Ark DPI consists of 27,620 nucleotides, excluding poly (A) tail, and comprises ten open reading frames. Comparative sequence analysis of Ark DPI with other IBV strains shows striking similarity to the Conn, Gray, JMK, and Ark 99, which were circulating during that time period. Furthermore, comparison of the Ark genome with other coronaviruses demonstrates a close relationship to turkey coronavirus. Among non-structural genes, the 5'untranslated region (UTR), 3C-like proteinase (3CLpro) and the polymerase (RdRp) sequences are 100% identical to the Gray strain. Among structural genes, S1 has 97% identity with Ark 99; S2 has 100% identity with JMK and 96% to Conn; 3b 99%, and 3C to N is 100% identical to Conn strain. Possible recombination sites were found at the intergenic region of spike gene, 3'end of S1 and 3a gene. Independent recombination events may have occurred in the entire genome of Ark DPI, involving four different IBV strains, suggesting that genomic RNA recombination may occur in any part of the genome at number of sites. Hence, we speculate that the Ark DPI strain originated from the Conn strain, but diverged and evolved independently by point mutations and recombination between field strains.

  17. Complete genomic sequence analysis of infectious bronchitis virus Ark DPI strain and its evolution by recombination

    Directory of Open Access Journals (Sweden)

    Gelb Jack

    2008-12-01

    Full Text Available Abstract An infectious bronchitis virus Arkansas DPI (Ark DPI virulent strain was sequenced, analyzed and compared with many different IBV strains and coronaviruses. The genome of Ark DPI consists of 27,620 nucleotides, excluding poly (A tail, and comprises ten open reading frames. Comparative sequence analysis of Ark DPI with other IBV strains shows striking similarity to the Conn, Gray, JMK, and Ark 99, which were circulating during that time period. Furthermore, comparison of the Ark genome with other coronaviruses demonstrates a close relationship to turkey coronavirus. Among non-structural genes, the 5'untranslated region (UTR, 3C-like proteinase (3CLpro and the polymerase (RdRp sequences are 100% identical to the Gray strain. Among structural genes, S1 has 97% identity with Ark 99; S2 has 100% identity with JMK and 96% to Conn; 3b 99%, and 3C to N is 100% identical to Conn strain. Possible recombination sites were found at the intergenic region of spike gene, 3'end of S1 and 3a gene. Independent recombination events may have occurred in the entire genome of Ark DPI, involving four different IBV strains, suggesting that genomic RNA recombination may occur in any part of the genome at number of sites. Hence, we speculate that the Ark DPI strain originated from the Conn strain, but diverged and evolved independently by point mutations and recombination between field strains.

  18. Replication of Infectious Bronchitis Virus in the Chicken Mesenchymal Stem Cells

    Directory of Open Access Journals (Sweden)

    M.H. Mohammed

    2012-06-01

    Full Text Available The susceptibility of the chicken mesenchymal stem cells to infectious bronchitis virus was characterized after twenty consecutive passages in chicken mesenchymal stemm cells. Virus replication was monitored by cytopathic observation, indirect immunoperoxidase, and reverse transcription polymerase chain reaction. At 72 h post-infection (p.i. in third passage, the cytopathic effect was characterized by rounding up of cell, monolayer detachment, intracytoplasmic brownish colouration was readily observed by from 24h p.i in third passage, and at all times the extracted viral RNA from IBV-infected monolayers was demonstrated by reverse transcription polymerase chain reaction. Tissue culture effective dose50 was used to measure virus titration performed on chicken mesenchymal stem cells and the titres in twenty passages was 108.6 TID50/ml. The results obtained in this study suggested that the chicken mesenhymal stem cells can be used for adaptation IBV and may be considered a step forward for the use of these cells in the future for IBV vaccine production

  19. Infectious bronchitis viruses with naturally occurring genomic rearrangement and gene deletion.

    Science.gov (United States)

    Hewson, Kylie A; Ignjatovic, Jagoda; Browning, Glenn F; Devlin, Joanne M; Noormohammadi, Amir H

    2011-02-01

    Infectious bronchitis viruses (IBVs) are group III coronaviruses that infect poultry worldwide. Genetic variations, including whole-gene deletions, are key to IBV evolution. Australian subgroup 2 IBVs contain sequence insertions and multiple gene deletions that have resulted in a substantial genomic divergence from international IBVs. The genomic variations present in Australian IBVs were investigated and compared to those of another group III coronavirus, turkey coronavirus (TCoV). Open reading frames (ORFs) found throughout the genome of Australian IBVs were analogous in sequence and position to TCoV ORFs, except for ORF 4b, which appeared to be translocated to a different position in the subgroup 2 strains. Subgroup 2 strains were previously reported to lack genes 3a, 3b and 5a, with some also lacking 5b. Of these, however, genes 3b and 5b were found to be present but contained various mutations that may affect transcription. In this study, it was found that subgroup 2 IBVs have undergone a more substantial genomic rearrangements than previously thought.

  20. Transient dominant selection for the modification and generation of recombinant infectious bronchitis coronaviruses.

    Science.gov (United States)

    Keep, Sarah M; Bickerton, Erica; Britton, Paul

    2015-01-01

    We have developed a reverse genetics system for the avian coronavirus infectious bronchitis virus (IBV) in which a full-length cDNA corresponding to the IBV genome is inserted into the vaccinia virus genome under the control of a T7 promoter sequence. Vaccinia virus as a vector for the full-length IBV cDNA has the advantage that modifications can be introduced into the IBV cDNA using homologous recombination, a method frequently used to insert and delete sequences from the vaccinia virus genome. Here, we describe the use of transient dominant selection as a method for introducing modifications into the IBV cDNA; this has been successfully used for the substitution of specific nucleotides, deletion of genomic regions, and the exchange of complete genes. Infectious recombinant IBVs are generated in situ following the transfection of vaccinia virus DNA, containing the modified IBV cDNA, into cells infected with a recombinant fowlpox virus expressing T7 DNA-dependent RNA polymerase.

  1. [The Isolation and Identification of Infectious Bronchitis Virus PTFY Strain in Muscovy Ducks].

    Science.gov (United States)

    Wu, Xiaoping; Pan, Shulei; Zhou, Wuduo; Wu, Yijiang; Huang, Yifan; Wu, Baocheng

    2016-03-01

    In July 2009, some farms of breeding Muscovy ducks on the peak of egg laying suffered the decrease of hatching rate and the quality of the eggs showing low mortality and no evident respiratory symptoms. The swelling and congestive ovary was visible after autopsy. This study was brought out for the diagnosis of these cases. The virus was isolated and identified by the methods of virus culture in chicken embryo, physical and chemical properties test, hemagglutinin test, NDV (Newcastle diseases Virus) interference test, electron microscope observation, pathogenicity test and the gene sequence analysis. The results indicated the virus showed the characters of inducing dwarf embryo after inocubation, the sensibility to lipid solvent and the hemagglutination capacity after pancreatic enzyme treatment, the typical morphology of coronavirus, the interference to NDV replication and the homology among 84.7% - 99% of the particial N gene sequences to the reference IBV (Avian infectious bronchitis virus) strains. The strain was identified as IBV isolate and this study confirmed the pathogenicity of IBV to Muscovy ducks. PMID:27396165

  2. Progress and Challenges toward the Development of Vaccines against Avian Infectious Bronchitis

    Directory of Open Access Journals (Sweden)

    Faruku Bande

    2015-01-01

    Full Text Available Avian infectious bronchitis (IB is a widely distributed poultry disease that has huge economic impact on poultry industry. The continuous emergence of new IBV genotypes and lack of cross protection among different IBV genotypes have been an important challenge. Although live attenuated IB vaccines remarkably induce potent immune response, the potential risk of reversion to virulence, neutralization by the maternal antibodies, and recombination and mutation events are important concern on their usage. On the other hand, inactivated vaccines induce a weaker immune response and may require multiple dosing and/or the use of adjuvants that probably have potential safety risks and increased economic burdens. Consequently, alternative IB vaccines are widely sought. Recent advances in recombinant DNA technology have resulted in experimental IB vaccines that show promise in antibody and T-cells responses, comparable to live attenuated vaccines. Recombinant DNA vaccines have also been enhanced to target multiple serotypes and their efficacy has been improved using delivery vectors, nanoadjuvants, and in ovo vaccination approaches. Although most recombinant IB DNA vaccines are yet to be licensed, it is expected that these types of vaccines may hold sway as future vaccines for inducing a cross protection against multiple IBV serotypes.

  3. What is chronic cough in children?

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    Iulia eIOAN

    2014-08-01

    Full Text Available The cough reflex is modulated throughout growth and development. Cough – but not expiration reflex – appears to be absent at birth, but increases with maturation. Thus, acute cough is the most frequent respiratory symptom during the first few years of life. Later on, the pubertal development seems to play a significant role in changing of the cough threshold during childhood and adolescence resulting in sex-related differences in cough reflex sensitivity in adulthood. Asthma is the major cause of chronic cough in children. Prolonged acute cough is usually related to the long-lasting effects of a previous viral airway infection or to the particular entity called protracted bacterial bronchitis. Cough pointers and type may orient towards specific aetiologies, such as barking cough in croup or tracheomalacia, paroxystic whooping cough in Pertussis. Cough is productive in protracted bacterial bronchitis, sinusitis or bronchiectasis. Cough is usually associated with wheeze or dyspnea on exertion in asthma; however, it may be the sole symptom in cough variant asthma. Thus, paediatric cough has particularities differentiating it from adult cough, so the approach and management should be developmentally specific.

  4. Bronquitis infecciosa aviar: diagnóstico y control -Avian infectious bronchitis: diagnosis and control

    Directory of Open Access Journals (Sweden)

    Acevedo Beiras, Ana María

    2010-03-01

    Full Text Available ResumenLa bronquitis infecciosa aviar (BIA es una enfermedad que ocasiona unimpacto socio-económico severo en la industria avícola mundial. Es unaenfermedad respiratoria aguda, altamente contagiosa, caracterizadaprimariamente por signos respiratorios en los pollos en crecimiento. En las ponedoras, la sintomatología respiratoria es menor pero provoca una disminución marcada en la producción y calidad del huevo. El agente etiológico de esta enfermedad es el virus de la bronquitis infecciosa aviar, un Coronavirus del grupo 3 de la familia Coronaviridae, orden Nidovirales. El virus se replica en los tejidos del tracto respiratorio y en muchos tejidos a lo largo del tracto alimentario. Este virus puede infectar otras especies de aves además de los pollos. Los signos clínicos característicos son tos, estornudos, estertores traqueales, ojos acuosos, letargo y en los pollos, especialmente los jóvenes, se presentan descargas nasales. Estos signos son indicativos pero no tienen por sí solo valor diagnóstico y la confirmación requiere el aislamiento o la demostración directa de la presencia del virus aunque la serología puede ser útil en algunas circunstancias. El diagnóstico de laboratorio requiere el aislamiento viral y su identificación. Se emplean las técnicas de reacción en cadena de la polimerasa (RT-PCR, inhibición de la hemaglutinación (HI y ensayos inmunoenzimáticos (ELISA, así como la microscopía electrónica, anticuerpos monoclonales, virus neutralización (VN, inmunohistoquímica,ensayos de inmunofluorescencia y de inmunización desafío en pollos. Son ampliamente usadas vacunas vivas e inactivadas en el control de laenfermedad.SummaryAvian infectious bronchitis (BIA is a disease that provokes a severe socioeconomic impact in poultry world industry. It is a breathing sharp disease, highly contagious, characterized primarily for breathing signs in chickens in growth. In the egg-laying, the breathing sintomatology is

  5. Cytokines in the pathogenesis of chronic obstructive pulmonary disease.

    Science.gov (United States)

    Reid, P T; Sallenave, J-M

    2003-01-01

    Chronic obstructive pulmonary disease (COPD) is a common cause of morbidity and mortality. The term is heterogenous and encompasses a number of distinct but often overlapping phenotypes including chronic bronchitis, small airways obstruction, emphysema and in some individuals, a systemic component. Although there have been significant advances in understanding the pathophysiology of COPD, understanding of the role of the inflammation in the pathogenesis of the condition remains in its infancy. Indeed, cytokines that are known to orchestrate the inflammatory response in asthma and other inflammatory diseases are only beginning to be reported in COPD. In this review, we highlight the potential role of cytokines in the development of mucus hypersecretion observed in chronic bronchitis and the morphological changes observed in the small airways and airspaces contributing to the development of airflow limitation and respiratory failure respectively. We report evidence that exacerbations are linked to increased expression of pro-inflammatory cytokines and that the wasting and skeletal muscle dysfunction observed in some patients is most probably related to the presence of a systemic inflammatory response. In addition transgenic and gene therapy technology has been used to explore the temporal and co-ordinated role of cytokines in the development of COPD animal models. Enhanced understanding of the events involved in the pathogenesis of COPD will lead to the development of therapy with potential to modify the observed progressive decline in lung function and impact on the development of the illness. PMID:12570672

  6. Morphologic observations on respiratory tracts of chickens after hatchery infectious bronchitis vaccination and formaldehyde fumigation.

    Science.gov (United States)

    Di Matteo, A M; Soñez, M C; Plano, C M; von Lawzewitsch, I

    2000-01-01

    The histologic changes in the respiratory tracts of chickens were evaluated after hatchery fumigation with 40% formaldehyde vapors and vaccination against infectious bronchitis virus with live attenuated vaccine (Massachusetts serotype). One-day-old chickens were housed in four isolation units in controlled environmental conditions, fed and watered ad libitum, and separated into four groups: 1) fumigated and vaccinated birds (FV group); 2) nonfumigated and vaccinated birds (NFV group); 3) fumigated and nonvaccinated birds (FNV group); and 4) control group (C group). All birds were tested to be free from Mycoplasma gallisepticum and Mycoplasma synoviae. After necropsy on the first, eighth, and twenty-sixth days after birth, samples from tracheal upper portion and lungs were conventionally processed for light, scanning, and transmission electron microscopy. Tissue response was monitored by microscopic examination of trachea and lung. On the first day of observation, fumigated and vaccinated birds (FV group) showed extensively damaged tracheal epithelium with exfoliated areas and some active glands with electrodense granules, and in the lung, the primary bronchi epithelium had disorganized cilia and abundant lymphocytes, with emphysematous areas in tertiary bronchus. On day 8 after vaccination, cubical and cylindrical tracheal cell proliferation was observed, and on day 26, ciliated columnar epithelium was almost regenerated with heterophil corion infiltration, and hyaline cartilage nodules appeared in parabronchi. The nonfumigated and vaccinated birds (NFV) revealed less injury on the epithelial surface and a more rapid response to epithelial regeneration than the in only fumigated animals (FNV). The control group did not show remarkable morphologic changes. Postvaccinal and fumigation effects on the upper respiratory tract were temporary, whereas in lungs, increased emphysema, cartilage nodules in the interchange zone, and general lymphocyte infiltration had caused

  7. PREPARATION AND EVALUATION OF VITAMIN E ADJUVANTED OIL EMULSIFIED INFECTIOUS BRONCHITIS EXPERIMENTAL VACCINE

    Directory of Open Access Journals (Sweden)

    S. ALI, M. ARSHAD, M. SIDDIQUE AND M. ASHRAF

    2007-10-01

    Full Text Available The present study was conducted to prepare oil emulsified (OE infectious bronchitis (IB experimental vaccines. The vaccines were prepared using the vaccinal strain H-120 Infectious Bonchitis virus (IBV. The virus was cultivated in 9-day old embryonated eggs via allantoic cavity route. Allantoic-amniotic fluid (AAF was collected and inactivated with formalin @ 0.12%. Water in oil emulsion was prepared by adding one part of AAF to four parts of mineral oil containing water phase (Tween 80 and oil phase (Span 80 surfactants. Hydrophile lypohile balance (HLB of the emulsion was maintained at 7.0. Two oil emulsified experimental vaccines were prepared. Vaccine-I was prepared without vitamin E and Vaccine-II with vitamin E (300 mg/ml. A total of 120 day-old broiler breeder chickens were divided into 4 groups, A, B, C, and D, each having 30 birds. At the age of 21 days, experimental Vaccine-I, experimental vaccine-II and commercial IB killed (H-120 vaccine were inoculated @ 0.5 ml in the birds of groups A, B and C, respectively. Group D was maintained as nonvaccinated control. Efficacy of the vaccines was evaluated on the basis of humoral immune response (haemagglutination inhibition antibody titres against IB in the four groups. The seven weeks cumulative mean antibody titres (CMT of each group were calculated. The highest CMT was observed in group B (130, followed by group C (69, group A (58 and group D (17. Statistical analysis showed that haemagglutination inhibition (HI antibody titres in group B (vaccine- II were significantly higher than those of groups A, B and C (P< 0.05.

  8. A Mitochondrial Perspective of Chronic Obstructive Pulmonary Disease Pathogenesis

    Science.gov (United States)

    Shadel, Gerald S.

    2016-01-01

    Chronic obstructive pulmonary disease (COPD) encompasses several clinical syndromes, most notably emphysema and chronic bronchitis. Most of the current treatments fail to attenuate severity and progression of the disease, thereby requiring better mechanistic understandings of pathogenesis to develop disease-modifying therapeutics. A number of theories on COPD pathogenesis have been promulgated wherein an increase in protease burden from chronic inflammation, exaggerated production of reactive oxygen species and the resulting oxidant injury, or superfluous cell death responses caused by enhanced cellular injury/damage were proposed as the culprit. These hypotheses are not mutually exclusive and together likely represent the multifaceted biological processes involved in COPD pathogenesis. Recent studies demonstrate that mitochondria are involved in innate immune signaling that plays important roles in cigarette smoke-induced inflammasome activation, pulmonary inflammation and tissue remodeling responses. These responses are reviewed herein and synthesized into a view of COPD pathogenesis whereby mitochondria play a central role.

  9. Clinical significance of determination of changes of serum SOD, TNF-α levels and T-cell subsets distribution type after treatment in pediatric patients with acute bronchitis

    International Nuclear Information System (INIS)

    Objective: To study the changes of serum SOD, TNF-α levels and T-cell subsets distribution type after treatment in pediatric patients with acute bronchitis. Methods: Serum SOD, TNF-α levels (with RIA) and T-cell subsets distribution type (with monoclonal antibody technique) were detected both before and after treatment in 39 pediatric patients with acute bronchitis as well as in 35 controls. Results: Before treatment, the serum levels of SOD, CD4/CD8 ratios were significantly lower and serum TNF-α levels significantly higher in the patients than those in the controls (P0.05). Conclusion: Determination of serum SOD, TNF-α levels and T-cell subsets distribution type is clinically meaningful in pediatric patients with acute bronchitis. (authors)

  10. Increasing awareness of recognition of chronic obstructive pulmonary disease

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ The medical community should, by now, be well aware of the importance of chronic obstructive pulmonary disease (COPD), an increasingly common condition with high morbidity and mortality. In modern terms, COPD has come to signify concurrent chronic bronchitis, asthmatic bronchitis and emphysema. Cigarette smoking has long been recognized as the predominant aetiological agent. Arterial hypoxaemia, a frequent complication of COPD, can lead to pulmonary hypertension and cor pulmonale. COPD affects over 5% of the adult population and is the only major cause of death whose morbidity and mortality are increasing in several countries.1 In China, it is difficult to quantify how many people are affected with COPD. However, a recent epidemiological survey indicated that COPD prevalence was 8.2% in China. COPD prevalence in men was significantly higher than in women (12.4% cf 5.1%). The prevalence in rural areas was higher than that in urban areas (8.8% cf 7.8%). Of patients with COPD, 61.5% were smokers. The report also stated that COPD is the major cause of death in rural areas in China and the fourth leading cause of death in urban areas, rising to the third leading cause of death by 2020.2 The prevalence of the disease increases with age with highest rates seen in people over the age of 70 years. COPD is the only major cause of mortality with a rising incidence and prevalence worldwide, rendering it an increasingly worrisome

  11. Infectious bronchitis in Brazilian chickens: current data and observations of field service personnel

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    EN Silva

    2010-09-01

    Full Text Available The infectious bronchitis virus (IBV was detected for the first time in Brazil by Hipólito in 1957 in chickens sold life in the municipal market of Belo Horizonte, MG, when commercial poultry production was just starting in that country. The Massachusetts (Mass serotype was identified. However, the clinical disease was only observed in 1975, when poultry production was intensely growing. The extensive outbreak produced the classical condition in layers and breeders, affecting egg production and quality, whereas broilers presented respiratory and "nephritis-nephrosis" signs. The disease rapidly spread to all poultry-producing regions in the country, and in 1979, both the imports and the manufacturing of live vaccines against IB strains Mass, H120 and H52, were licensed. In 1980, inactivated vaccines were introduced. Molecular techniques, particularly PCR, started to bed in the identification of IBV. A retrospective analysis showed that, up to 1989, the main IBV strain circulating in Brazil was Mass. However, other studies shows the presence of a wide diversity of IBV strains in Brazil since the first strains were isolated, even before vaccination was introduced. Most researchers agree that the incidence of IBV different from Mass has increased, including of exclusively Brazilian genotypes, different from those described in other countries. Indeed, during the last few years, the number of genotypical variants has been much higher than that of the classical Mass serotype. Clinically, in addition of the classic presentations, atypical forms such as testicular atrophy and stones in the epidydimis associated to low fertility have been described. Serological techniques started to be used in vaccination monitoring and as a diagnostic tool. Serological response standards were developed, and have shown to be very useful to determine the expected profile in vaccination programs and when clinical disease is suspected. However, the immuno-enzymatic test

  12. High-resolution CT in patients with chronic airflow obstruction: correlation with clinical diagnosis and pulmonary function test

    International Nuclear Information System (INIS)

    To determine the utility of HRCT in the diagnosis of chronic airflow obstruction and to correlate the morphologic abnormalities revealed by this modality with functional impairment in patients with chronic airflow obstruction. This study involved 80 patients with chronic airflow obstruction who underwent HRCT and a pulmonary function test. Final clinical diagnosis in these patients was determined by a chest physician on the basis of clinical features, bronchoscopy, pulmonary function test, and HRCT. In order to diagnose and determine the extent of areas of decreased attenuation revealed by HRCT (the CT score), the findings of HRCT were retrospectively reviewed by two radiologists, who reached a consensus. Clinical and HRCT diagnoses were then compared, and the rate of agreement between them was calculated. The relationship between the extent of areas of decreased attenuation revealed by HRCT and by FEV1/FVC was evaluated using Correl's account and Student's unpaired t-test. The agreement rate between clinical and HRCT diagnoses was 77.5% (62/80). The rates for bronchiectasis (88.9%, 24/27), emphysema (93.9%, 31/33), and bronchiolitis obliterans (100%, 6/6) were considerably higher than those for chronic bronchitis and bronchial asthma. The correlation rate between CT score and FEV1/FVC was significant in bronchiectasis (p less than 0.05; r: -0.76) and bronchiolitis obliterans (p less than 0.01; r: -0.66), but not in cases involving emphysema, bronchial asthma, or chronic bronchitis (p greater than 0.05). HRCT is valuable in the diagnosis and prediction of physiologic impairment in patients with bronchiectasis and bronchiolitis obliterans, but has limited value in those with emphysema, chronic bronchitis or asthma. (author)

  13. High-resolution CT in patients with chronic airflow obstruction: correlation with clinical diagnosis and pulmonary function test

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Ki Taek; Kang, Eun Young; Rhee, Ji Yong; Kim, Jin Hyung; Choi, Jung Ah; Cho, Jae Yoen; Oh, Yu Whan; Suh, Won Hyuck [College of Medicine, Korea University, Seoul (Korea, Republic of)

    2000-06-01

    To determine the utility of HRCT in the diagnosis of chronic airflow obstruction and to correlate the morphologic abnormalities revealed by this modality with functional impairment in patients with chronic airflow obstruction. This study involved 80 patients with chronic airflow obstruction who underwent HRCT and a pulmonary function test. Final clinical diagnosis in these patients was determined by a chest physician on the basis of clinical features, bronchoscopy, pulmonary function test, and HRCT. In order to diagnose and determine the extent of areas of decreased attenuation revealed by HRCT (the CT score), the findings of HRCT were retrospectively reviewed by two radiologists, who reached a consensus. Clinical and HRCT diagnoses were then compared, and the rate of agreement between them was calculated. The relationship between the extent of areas of decreased attenuation revealed by HRCT and by FEV1/FVC was evaluated using Correl's account and Student's unpaired t-test. The agreement rate between clinical and HRCT diagnoses was 77.5% (62/80). The rates for bronchiectasis (88.9%, 24/27), emphysema (93.9%, 31/33), and bronchiolitis obliterans (100%, 6/6) were considerably higher than those for chronic bronchitis and bronchial asthma. The correlation rate between CT score and FEV1/FVC was significant in bronchiectasis (p less than 0.05; r: -0.76) and bronchiolitis obliterans (p less than 0.01; r: -0.66), but not in cases involving emphysema, bronchial asthma, or chronic bronchitis (p greater than 0.05). HRCT is valuable in the diagnosis and prediction of physiologic impairment in patients with bronchiectasis and bronchiolitis obliterans, but has limited value in those with emphysema, chronic bronchitis or asthma. (author)

  14. The Nature and Causes of Chronic Obstructive Pulmonary Disease: A Historical Perspective

    Directory of Open Access Journals (Sweden)

    C Peter W Warren

    2009-01-01

    Full Text Available Chronic obstructive pulmonary disease (COPD is the currently favoured name for the diseases formerly known as emphysema and bronchitis. COPD has been recognized for more than 200 years. Its cardinal symptoms are cough, phlegm and dyspnea, and its pathology is characterized by enlarged airspaces and obstructed airways. In the 19th century, the diagnosis of COPD depended on its symptoms and signs of a hyperinflated chest, and reduced expiratory breath sounds. The airflow obstruction evident on spirometry was identified in that century, but did not enter into clinical practice. Bronchitis, and the mechanical forces required to overcome its obstruction, was believed to be responsible for emphysema, although the inflammation present was recognized. The causes of bronchitis, and hence emphysema, included atmospheric and domestic air pollution, as well as dusty occupations. Cigarette smoking only became recognized as the dominant cause in the 20th century. The lessons learned of the risks for COPD in 19th-century Britain are very pertinent to the world today.

  15. Add-on treatment with nebulized hypertonic saline in a child with plastic bronchitis after the Glenn procedure

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    Grzegorz Lis

    2014-01-01

    Full Text Available Plastic bronchitis (PB, although a rare cause of airway obstruction, has mortality rates up to 50% in children after Fontan-type cardiac surgery. We present the case of an 18-month-old female patient with PB following pneumonia. At 6 months of age, the patient underwent the Glenn procedure due to functionally univentricular heart. Fiberoptic bronchoscopy revealed complete blockage of the left bronchus by mucoid casts. Pharmacotherapy consisted of glucocorticosteroids, azithromycin, and enalapril maleate. The child also received nebulized 3% NaCl solution, which proved to be beneficial. In children submitted to Fontan-type procedures, physicians must be alert for PB, which can be triggered by respiratory tract infection.

  16. Sialic Acid Binding Properties of Soluble Coronavirus Spike (S1 Proteins: Differences between Infectious Bronchitis Virus and Transmissible Gastroenteritis Virus

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    Christine Winter

    2013-07-01

    Full Text Available The spike proteins of a number of coronaviruses are able to bind to sialic acids present on the cell surface. The importance of this sialic acid binding ability during infection is, however, quite different. We compared the spike protein of transmissible gastroenteritis virus (TGEV and the spike protein of infectious bronchitis virus (IBV. Whereas sialic acid is the only receptor determinant known so far for IBV, TGEV requires interaction with its receptor aminopeptidase N to initiate infection of cells. Binding tests with soluble spike proteins carrying an IgG Fc-tag revealed pronounced differences between these two viral proteins. Binding of the IBV spike protein to host cells was in all experiments sialic acid dependent, whereas the soluble TGEV spike showed binding to APN but had no detectable sialic acid binding activity. Our results underline the different ways in which binding to sialoglycoconjugates is mediated by coronavirus spike proteins.

  17. Adjuvant Activity of Sargassum pallidum Polysaccharides against Combined Newcastle Disease, Infectious Bronchitis and Avian Influenza Inactivated Vaccines

    Directory of Open Access Journals (Sweden)

    Li-Jie Li

    2012-11-01

    Full Text Available This study evaluates the effects of Sargassum pallidum polysaccharides (SPP on the immune responses in a chicken model. The adjuvanticity of Sargassum pallidum polysaccharides in Newcastle disease (ND, infectious bronchitis (IB and avian influenza (AI was investigated by examining the antibody titers and lymphocyte proliferation following immunization in chickens. The chickens were administrated combined ND, IB and AI inactivated vaccines containing SPP at 10, 30 and 50 mg/mL, using an oil adjuvant vaccine as a control. The ND, IB and AI antibody titers and the lymphocyte proliferation were enhanced at 30 mg/mL SPP. In conclusion, an appropriate dose of SPP may be a safe and efficacious immune stimulator candidate that is suitable for vaccines to produce early and persistent prophylaxis.

  18. Serum levels of mannan-binding lectin in chickens prior to and during experimental infection with avian infectious bronchitis virus

    DEFF Research Database (Denmark)

    Juul-Madsen, H.R.; Munch, M.; Handberg, Kurt;

    2003-01-01

    or complement activation via MBL-associated serine proteases (MASP) -1 and -2. Thus, MBL plays a major role in the first-line innate defense against pathogens. We investigated the MBL concentrations in serum during experimental infectious bronchitis virus (IBV) infections in chickens. The results showed...... that the acute phase MBL response to infection with IBV was, to a degree (P inoculated after 12 h of rest (dark) or after 12 h of activity (light). The acute phase response in chickens challenged after 12 h of activity peaked after 4.6 d with an increase of 24......, the highest value was found in chickens inoculated after 12 h of activity. Thus, an inverse relation exists between the MBL response and the IBV specific antibody response. The ability of MBL to activate the complement cascade was tested in a heterologous system by deposition of human C4 on the chicken MBL...

  19. Elisa evaluation of the levels of antibodies against Infectious Bronchitis Virus in laying hens using egg yolk as substrate

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    RH Rauber

    2004-06-01

    Full Text Available The present work was carried out to compare Infectious Bronchitis Virus (IBV antibody titers in serum and egg yolk samples from laying hens. Sixty paired blood and egg samples were collected from laying hens of two farms. Serum samples were frozen, while egg yolk samples were diluted (1:500 before freezing. Serum and yolk samples were tested for the presence of IBV antibodies by indirect ELISA (commercial kit and titers were compared by a correlation test (alpha=0.05. There was a high correlation (r=0.62 between the two kinds of samples, which means that titers of IBV antibodies in the egg yolk and in serum samples are quite the same. Considering that blood collection causes deep stress that leads to economic losses, and since eggs are collected daily on the farm, results reported here are of importance to poultry production.

  20. Currently available cough suppressants for chronic cough.

    Science.gov (United States)

    Chung, Kian Fan

    2008-01-01

    Chronic cough is a common symptom but only a fraction of patients seek medical attention. Addressing the causes of chronic cough may lead to control of cough; however, this approach is not always successful since there is a certain degree of failure even when the cause(s) of cough are adequately treated; in idiopathic cough, there is no cause to treat. Persistent cough may be associated with deterioration of quality of life, and treatment with cough suppressants is indicated. Currently available cough suppressants include the centrally acting opioids such as morphine, codeine, and dextromethorphan. Peripherally acting antitussives include moguisteine and levodropropizine. Early studies report success in reducing cough in patients with chronic bronchitis or COPD; however, a carefully conducted study showed no effect of codeine on cough of COPD. Success with these cough suppressants can be achieved at high doses that are associated with side effects. Slow-release morphine has been reported to be useful in controlling intractable cough with good tolerance to constipation and drowsiness. There have been case reports of the success of centrally acting drugs such as amitryptiline, paroxetine, gabapentin, and carbamezepine in chronic cough. New opioids such as nociceptin or antagonists of TRPV1 may turn out to be more effective. Efficacy of cough suppressants must be tested in double-blind randomised trials using validated measures of cough in patients with chronic cough not responding to specific treatments. Patients with chronic cough are in desperate need of effective antitussives that can be used either on demand or on a long-term basis.

  1. Currently available cough suppressants for chronic cough.

    Science.gov (United States)

    Chung, Kian Fan

    2008-01-01

    Chronic cough is a common symptom but only a fraction of patients seek medical attention. Addressing the causes of chronic cough may lead to control of cough; however, this approach is not always successful since there is a certain degree of failure even when the cause(s) of cough are adequately treated; in idiopathic cough, there is no cause to treat. Persistent cough may be associated with deterioration of quality of life, and treatment with cough suppressants is indicated. Currently available cough suppressants include the centrally acting opioids such as morphine, codeine, and dextromethorphan. Peripherally acting antitussives include moguisteine and levodropropizine. Early studies report success in reducing cough in patients with chronic bronchitis or COPD; however, a carefully conducted study showed no effect of codeine on cough of COPD. Success with these cough suppressants can be achieved at high doses that are associated with side effects. Slow-release morphine has been reported to be useful in controlling intractable cough with good tolerance to constipation and drowsiness. There have been case reports of the success of centrally acting drugs such as amitryptiline, paroxetine, gabapentin, and carbamezepine in chronic cough. New opioids such as nociceptin or antagonists of TRPV1 may turn out to be more effective. Efficacy of cough suppressants must be tested in double-blind randomised trials using validated measures of cough in patients with chronic cough not responding to specific treatments. Patients with chronic cough are in desperate need of effective antitussives that can be used either on demand or on a long-term basis. PMID:17909897

  2. Invasive Aspergillus infections in hospitalized patients with chronic lung disease

    Directory of Open Access Journals (Sweden)

    Wessolossky M

    2013-05-01

    Full Text Available Mireya Wessolossky,1 Verna L Welch,2 Ajanta Sen,1 Tara M Babu,1 David R Luke21Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, MA, USA; 2Medical Affairs, Pfizer Inc, Collegeville, PA, USABackground: Although invasive pulmonary aspergillosis (IPA is more prevalent in immunocompromised patients, critical care clinicians need to be aware of the occurrence of IPA in the nontraditional host, such as a patient with chronic lung disease. The purpose of this study was to describe the IPA patient with chronic lung disease and compare the data with that of immunocompromised patients.Methods: The records of 351 patients with Aspergillus were evaluated in this single-center, retrospective study for evidence and outcomes of IPA. The outcomes of 57 patients with chronic lung disease and 56 immunocompromised patients were compared. Patients with chronic lung disease were defined by one of the following descriptive terms: emphysema, asthma, idiopathic lung disease, bronchitis, bronchiectasis, sarcoid, or pulmonary leukostasis.Results: Baseline demographics were similar between the two groups. Patients with chronic lung disease were primarily defined by emphysema (61% and asthma (18%, and immunocompromised patients primarily had malignancies (27% and bone marrow transplants (14%. A higher proportion of patients with chronic lung disease had a diagnosis of IPA by bronchoalveolar lavage versus the immunocompromised group (P < 0.03. The major risk factors for IPA were found to be steroid use in the chronic lung disease group and neutropenia and prior surgical procedures in the immunocompromised group. Overall, 53% and 69% of chronic lung disease and immunocompromised patients were cured (P = 0.14; 55% of chronic lung patients and 47% of immunocompromised patients survived one month (P = 0.75.Conclusion: Nontraditional patients with IPA, such as those with chronic lung disease, have outcomes and mortality similar to that in the

  3. Multi-centre retrospective analysis of clinical diagnosis and treatment for chronic cough

    Directory of Open Access Journals (Sweden)

    Xiao-ming CHENG

    2011-02-01

    Full Text Available Objective To explore the clinical characteristics and the present status of diagnosis and treatment of chronic cough.Methods The clinical data of 238 in-patients and out-patients of Departments of Respiratory Diseases from 4 teaching hospitals of Chongqing Municipality were collected from Oct.2008 to Dec.2009,and their clinical characteristics,diagnosis and therapeutic effects were retrospectively analyzed.Results A total of 238 patients were enrolled,most of them complained of dry cough and night cough.Throat symptoms were most common,including itching or foreign body sensation,throat discomfort and gastro-oesophageal reflux.Congestion of pharynx and cobblestone like changes in posterior pharyngeal wall were the most common signs in patients with chronic cough.Among all the supplementary examinations,bronchial provocation test resulted in highest positive rate.Etiological diagnosis was done in a total of 254 case-times for diseases leading to chronic cough,among them upper airway cough syndrome(UACS was suspected in 115 case-times.cough variant asthma(CVA in 42 case-times,and cough due to gastroesophageal reflux(GERC in 53 case-times.After the specific treatment targeting UACS,CVA and GERC,in 152 case-times improvement was found after follow-up,including 56,27 and 21 case-times,respectively,with an effective rate of 68.4%(104/152.The final diagnosis for the other 44 case-times with chronic cough was chronic tonsillitis,chronic bronchitis,eosinophilic bronchitis and angiotensin converting enzyme inhibitor(ACEI induced cough.A definite diagnosis was finally made in 148 out of a total of 254 casses,with a diagnostic rate of 58.3%(148/254.Conclusion The final diagnostic rate in etiology of chronic cough is still poor nowadays in our country,and empirical treatment is still the main practice for chronic cough.

  4. Pathophysiological Implication of Computed Tomography Images of Chronic Pulmonary Aspergillosis.

    Science.gov (United States)

    Ando, Tsunehiro; Tochigi, Naobumi; Gocho, Kyoko; Moriya, Atsuko; Ikushima, Soichiro; Kumasaka, Toshio; Takemura, Tamiko; Shibuya, Kazutoshi

    2016-03-23

    Chronic pulmonary aspergillosis (CPA) is a refractory disorder that needs long-term antifungal treatment and occasionally results in fatal respiratory failure and hemoptysis. However, the pathological features of the disorder have not been thoroughly delineated. Thirty cases were therefore analyzed clinically and histologically to elucidate the pathophysiology of CPA. The subjects comprised 14 individuals who underwent surgical removal and 16 patients who died. No subject exhibited a severely immunocompromised state. The main symptoms included cough, hemosputum, and dyspnea. Chest computed tomography (CT) findings revealed a cavity, fungus ball, and consolidation and/or ground glass opacity (GGO); 27 serial CT scans showed enlarged consolidation and/or GGO (70%), dilatation of the cavity (26%), and extension to the opposite lung (22%). Histopathological findings revealed a cavity with ulceration, bronchitis, and various degrees of organizing pneumonia (OP) that were correlated with the area of consolidation and GGO on the CT scan. The essential pathophysiology of CPA can be understood as an active state of ulceration of the cavity and/or erosive bronchitis caused by contact with the fungus ball, which may play a significant role in the development of OP. Consequently, OP is thought to reflect respiratory failure that relates to the prognosis of CPA. PMID:26166500

  5. [Mucolytics in acute and chronic respiratory tract disorders. II. Uses for treatment and antioxidant properties].

    Science.gov (United States)

    Kupczyk, Maciej; Kuna, Piotr

    2002-03-01

    In the first part of our editorial we reviewed the possible factors responsible for mucus hypersecretion in acute and chronic pulmonary diseases. The present paper presents the results of studies proving, that mucolytics are useful in adjunctive therapy of respiratory tract disorders. Mucolytic agents such as Ambroxol and N-acetylcysteine are able to alter the secretion of mucus and its physical properties which results in improvement of mucociliary clearance. Current evidence indicate, that these drugs are effective, especially in chronic obstructive pulmonary disease, asthma and acute bronchitis. They produce a modest improvement in symptom control and lung function. It has been demonstrated that there is a synergism between mucolytics and antibiotics in the treatment of exacerbation of chronic bronchitis. Moreover, they act as scavengers of reactive oxygen species. Ambroxol is able to inhibit mediator release involved in the pathogenesis of allergic inflammation. As mucolytics are cheap and well-tolerated they are beneficial in the therapy of patients suffering from respiratory tract disorders. PMID:12053601

  6. Proteomic analysis of chicken embryonic trachea and kidney tissues after infection in ovo by avian infectious bronchitis coronavirus

    OpenAIRE

    Kong Xiangang; Geng Heyuan; Shao Yuhao; Han Zongxi; Cao Zhongzan; Liu Shengwang

    2011-01-01

    Abstract Background Avian infectious bronchitis (IB) is one of the most serious diseases of economic importance in chickens; it is caused by the avian infectious coronavirus (IBV). Information remains limited about the comparative protein expression profiles of chicken embryonic tissues in response to IBV infection in ovo. In this study, we analyzed the changes of protein expression in trachea and kidney tissues from chicken embryos, following IBV infection in ovo, using two-dimensional gel e...

  7. Pathogenesis Progression of Avian Infectious Bronchitis Virus%鸡传染性支气管炎病毒致病机理的研究进展

    Institute of Scientific and Technical Information of China (English)

    余娟; 刘兴友; 王玲丽

    2011-01-01

    鸡传染性支气管是由鸡传染性支气管炎病毒引起鸡的一种急性高度接触性呼吸道传染病,由于病毒血清型较多,易于发生变异而难以免疫预防,成为养鸡业发展的重大阻力.文章就该病毒的致病机理方面的研究情况做一综述,为防制鸡传染性支气管炎提供科学依据.%Infectious bronchitis virus (IBV) is causative pathogen of infectious bronchitis (IB) , an acute, highly contagious respiratory disease in chickens, the infectious bronchitis virus has many serotypes and is easy to mutate, which has caused the difficulty for the disease's prevention, and impeded the development of poultry industry. This paper reviewed etiology, pathogenesis of the IBV in order to provide evidence for IB prevention and control.

  8. Relationship between the use of inhaled steroids for chronic respiratory diseases and early outcomes in community-acquired pneumonia.

    Directory of Open Access Journals (Sweden)

    Jordi Almirall

    Full Text Available BACKGROUND: The role of inhaled steroids in patients with chronic respiratory diseases is a matter of debate due to the potential effect on the development and prognosis of community-acquired pneumonia (CAP. We assessed whether treatment with inhaled steroids in patients with chronic bronchitis, COPD or asthma and CAP may affect early outcome of the acute pneumonic episode. METHODS: Over 1-year period, all population-based cases of CAP in patients with chronic bronchitis, COPD or asthma were registered. Use of inhaled steroids were registered and patients were followed up to 30 days after diagnosis to assess severity of CAP and clinical course (hospital admission, ICU admission and mortality. RESULTS: Of 473 patients who fulfilled the selection criteria, inhaled steroids were regularly used by 109 (23%. In the overall sample, inhaled steroids were associated with a higher risk of hospitalization (OR=1.96, p = 0.002 in the bivariate analysis, but this effect disappeared after adjusting by other severity-related factors (adjusted OR=1.08, p=0.787. This effect on hospitalization also disappeared when considering only patients with asthma (OR=1.38, p=0.542, with COPD alone (OR=4.68, p=0.194, but a protective effect was observed in CB patients (OR=0.15, p=0.027. Inhaled steroids showed no association with ICU admission, days to clinical recovery and mortality in the overall sample and in any disease subgroup. CONCLUSIONS: Treatment with inhaled steroids is not a prognostic factor in COPD and asthmatic patients with CAP, but could prevent hospitalization for CAP in patients with clinical criteria of chronic bronchitis.

  9. Patient-Specific Airway Wall Remodeling in Chronic Lung Disease.

    Science.gov (United States)

    Eskandari, Mona; Kuschner, Ware G; Kuhl, Ellen

    2015-10-01

    Chronic lung disease affects more than a quarter of the adult population; yet, the mechanics of the airways are poorly understood. The pathophysiology of chronic lung disease is commonly characterized by mucosal growth and smooth muscle contraction of the airways, which initiate an inward folding of the mucosal layer and progressive airflow obstruction. Since the degree of obstruction is closely correlated with the number of folds, mucosal folding has been extensively studied in idealized circular cross sections. However, airflow obstruction has never been studied in real airway geometries; the behavior of imperfect, non-cylindrical, continuously branching airways remains unknown. Here we model the effects of chronic lung disease using the nonlinear field theories of mechanics supplemented by the theory of finite growth. We perform finite element analysis of patient-specific Y-branch segments created from magnetic resonance images. We demonstrate that the mucosal folding pattern is insensitive to the specific airway geometry, but that it critically depends on the mucosal and submucosal stiffness, thickness, and loading mechanism. Our results suggests that patient-specific airway models with inherent geometric imperfections are more sensitive to obstruction than idealized circular models. Our models help to explain the pathophysiology of airway obstruction in chronic lung disease and hold promise to improve the diagnostics and treatment of asthma, bronchitis, chronic obstructive pulmonary disease, and respiratory failure. PMID:25821112

  10. Proteomic analysis of chicken embryonic trachea and kidney tissues after infection in ovo by avian infectious bronchitis coronavirus

    Directory of Open Access Journals (Sweden)

    Kong Xiangang

    2011-03-01

    Full Text Available Abstract Background Avian infectious bronchitis (IB is one of the most serious diseases of economic importance in chickens; it is caused by the avian infectious coronavirus (IBV. Information remains limited about the comparative protein expression profiles of chicken embryonic tissues in response to IBV infection in ovo. In this study, we analyzed the changes of protein expression in trachea and kidney tissues from chicken embryos, following IBV infection in ovo, using two-dimensional gel electrophoresis (2-DE coupled with matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry (MALDI-TOF-TOF MS. Results 17 differentially expressed proteins from tracheal tissues and 19 differentially expressed proteins from kidney tissues were identified. These proteins mostly related to the cytoskeleton, binding of calcium ions, the stress response, anti-oxidative, and macromolecular metabolism. Some of these altered proteins were confirmed further at the mRNA level using real-time RT-PCR. Moreover, western blotting analysis further confirmed the changes of annexin A5 and HSPB1 during IBV infection. Conclusions To the best of our knowledge, we have performed the first analysis of the proteomic changes in chicken embryonic trachea and kidney tissues during IBV infection in ovo. The data obtained should facilitate a better understanding of the pathogenesis of IBV infection.

  11. Comparative histopathology and immunohistochemistry of QX-like, Massachusetts and 793/B serotypes of infectious bronchitis virus infection in chickens.

    Science.gov (United States)

    Benyeda, Zs; Szeredi, L; Mató, T; Süveges, T; Balka, Gy; Abonyi-Tóth, Zs; Rusvai, M; Palya, V

    2010-11-01

    The aim of this study was to compare experimentally the pathogenicity and tissue distribution of the recently emerged QX-like strain of infectious bronchitis virus (IBV) with the widespread M41 and 793/B serotypes of the virus. Histopathological and immunohistochemical methods were employed to define the main sites of virus replication. One-day-old specific pathogen free chickens were inoculated with five different QX-like strains, or with the M41 and 793/B IBV strains and monitored for 42 days post-infection. Tracheal lesions developed in all infected birds, confirming the ability of all of the tested strains to induce respiratory disease. Replication of the isolates in the alimentary tract was detected, but the infection did not cause significant gut lesions. Four of the five QX-like IBV strains induced severe kidney lesions. Dilation of the oviduct with accumulation of serum-like fluid in the lumen of this structure, reported previously from field cases of QX-like IBV infection, was observed following experimental infection with all of the five QX-like strains. Microscopical and immunohistochemical examination of the affected oviducts did not help to elucidate the pathogenesis of this lesion.

  12. Cloning and Sequencing of S Gene of Novel Variant of Infectious Bronchitis Virus ZJ971 Isolates in China

    Institute of Scientific and Technical Information of China (English)

    ZHOU Ji-yong; CHENG Li-qin; SHEN Xing-yan; DING Hong-mei; WU Jian-xiang

    2002-01-01

    A novel proventriculopathogic variant (isolate ZJ971) of infectious bronchitis virus (IBV) was identified from enlarged proeventriculus of the sick chickens in the study. The S gene cDNA segment with 3.6 kb in length was amplified by RT-PCR with special primers from the ZJ971 viral isolate of (IBV) and cloned into plasmid pBluescript SK( + ). The recombinants containing S gene of IBV-ZJ971 isotate were identified by digestion of restriction enzyme EcoRI, BamHI and PCR amplification. The cloned S gene from isolate IBVZJ971 was composed of 3492 bp in length encoding for a polypeptide of 1080 amino acids. Comparing the nucleotide of S gene of IBV isolate ZJ971 with that of reported IBV strains Beaudette, M41, Ark99 and CuT2,the homology was 97.3%, 97.5%, 88.6% and 85.6%, respectively; and the homology of the deduced amino acids of S protein of IBV isolate ZJ971 was 96%, 96.3%, 86.1% and 83.1% respectively; especially, the mutation of 3241st nucleotide of S gene of IBV isolate ZJ971 from G to T resulted in the translating termination of S protein at 3240th nucleotide site.

  13. The presence of viral subpopulations in an infectious bronchitis virus vaccine with differing pathogenicity--a preliminary study.

    Science.gov (United States)

    Hewson, Kylie A; Scott, Peter C; Devlin, Joanne M; Ignjatovic, Jagoda; Noormohammadi, Amir H

    2012-06-13

    There are currently four commercially available vaccines in Australia to protect chickens against infectious bronchitis virus (IBV). Predominantly, IBV causes clinical signs associated with respiratory or kidney disease, which subsequently cause an increase in mortality rate. Three of the current vaccines belong to the same subgroup (subgroup 1), however, the VicS vaccine has been reported to cause an increased vaccinal reaction compared to the other subgroup 1 vaccines. Molecular anomalies detected in VicS suggested the presence of two major subspecies, VicS-v and VicS-del, present in the commercial preparation of VicS. The most notable anomaly is the absence of a 40 bp sequence in the 3'UTR of VicS-del. In this investigation, the two subspecies were isolated and shown to grow independently and to similar titres in embryonated chicken eggs. An in vivo investigation involved 5 groups of 20 chickens each and found that VicS-del grew to a significantly lesser extent in the chicken tissues collected than did VicS-v. The group inoculated with an even ratio of the isolated subspecies scored the most severe clinical signs, with the longest duration. These results indicate the potential for a cooperative, instead of an expected competitive, relationship between VicS-v and VicS-del to infect a host, which is reminiscent of RNA viral quasi-species.

  14. Clinical Practice Guidelines for Severe Chronic Obstructive Pulmonary Disease. Guía de práctica clínica para el tratamiento de la enfermedad pulmonar obstructiva crónica grave.

    Directory of Open Access Journals (Sweden)

    Inti Santana Carballosa

    2009-03-01

    Full Text Available Clinical Practice Guidelines for Severe Chronic Obstructive Pulmonary Disease. This concept includes simple chronic bronchitis, asthmatic bronchitis, chronic obstructive bronchitis, and pulmonary emphysema; although this two last are the most commonly included. Risk factors, classification and treatment are commented, stressing the strategy of mechanical ventilation and the indications for mechanical invasive and no invasive ventilation. It includes assessment guidelines focused on the most important aspects to be accomplished.Guía de práctica clínica para el tratamiento de la enfermedad pulmonar obstructiva crónica grave. Término que encierra a la bronquitis crónica simple, bronquitis asmática, bronquitis obstructiva crónica y enfisema pulmonar; aunque son las dos últimas las más comúnmente incluidas. Se comentan los factores de riesgo, clasificación y tratamiento con énfasis en la estrategia de ventilación mecánica, así como las indicaciones de ventilación mecánica invasiva y no invasiva. Concluye con su guía de evaluación, enfocada en los aspectos más importantes a cumplir.

  15. [Chronicity, chronicization, systematization of delusions].

    Science.gov (United States)

    Trapet, P; Fernandez, C; Galtier, M C; Gisselmann, A

    1984-05-01

    Chronicity in psychopathology is indicative of a term, a decay. Chronicization only leads the way to this term. Here, chronicization is taken literally as an inscription in the time course of delusions. The mechanism of systematization seems to be a central mark in the approach to chronic delusions. It is not an alienation or an irreversible closing but an attempted accommodation with reality in the life of psychotic subjects, irrespective of the delusional structure. The role of therapy and drug treatment as a follow-up may in that case assume another meaning.

  16. Application of Irwin diagnostic procedures for chronic cough

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    Guo-fang FENG

    2011-07-01

    Full Text Available Objective To explore the advantages and disadvantages of the diagnostic procedures suggested by the Irwin group,and summarize the experiences in diagnosis and treatment,and to beter understand the etiology,diagnosis,differential diagnosis and treatment of chronic cough.Methods Data of 118 patients,who were finally diagnosed as chronic cough according to the diagnostic procedures suggested by Irwin group in the First Affiliated Hospital of General Hospital of PLA in 2009,were retrospectivety analyzed.Results With the Irwin diagnostic procedures of chronic cough,118 patients were diagnosed definitely.The final diagnostic rate reached 100%.The duration to reach the final diagnosis was 1 day to 30 days.Of the 118 patients with chronic cough,113 were cured(96%.32 cases(27.1% were caused by asthma and related diseases(allergic rhinitis,allergic pharyngitis,cough variant asthma and eosinophilic bronchitis;28 cases(23.7% were due to upper airway cough syndrome and related diseases(chronic rhinitis,sinusitis,pharyngeal bursitis,postnasal drip syndrome,chronic laryngitis,and vocal cord polyps;23 cases(19.5% due to gastroesophageal reflux disease;14 cases(11.9% due to lower respiratory tract infection and related diseases(endobronchial tuberculosis,pulmonary tuberculosis,endotracheal mucosal adenocarcinoma,lung cancer,bronchiectasis,and pulmonary fibrosis;10 cases(8.5% due to cardiac insafficiency;6 cases(5.1% due to administration of angiotensin-converting enzyme inhibitor(ACEI-like antihypertensive agents;3 cases(2.5% were psychogenic cough,and 2 cases(1.7% were induced by other causes.Conclusions The Irwin diagnosis of chronic cough is a comprehensive and thorough procedure,and it should be used with delibcration in clinic.The etiology of chronic cough is complicated,mainly including asthma and related diseases,sinusitis and upper airway cough syndrome,and gastroesophageal reflux disease.

  17. [Therapeutic training and sports in chronic diseases of the lung].

    Science.gov (United States)

    Podolsky, A; Haber, P

    1993-01-01

    Training is defined as systematic physical activity in order to improve the physical working capacity, which causes measurable morphological and functional changes in organs. Effects and the rules of applying aerobic endurance training in patients with chronic diseases of the lungs are dealt with. Training does not replace the normal medication, but is an additional therapeutic mean in order to regain physical working capacity, lost by chronic immobilization in the natural course of disease. Contraindications are acute diseases and exacerbations, but not a certain degree of the disease. Training does not improve the lung function, but the function of the other organs, the physical working capacity ist based on (circulation, musculature). This helps to use optimally the remaining reserves of lung function. Methods of aerobic endurance training are described, the definition of aims, performance diagnostic and the finding of the exact doses of training according to intensity, duration, frequency and the weekly netto training time. The training in different diseases of the lungs is discussed: In asthma bronchiale the prophylaxis of the exercise induced asthma and permitted and forbidden drugs for asthmatics according to the rules of international olympic committee. In chronic bronchitis with arterial hypoxemia, in restrictive lung diseases and in pulmonary hypertension. At last the way to prescribing training for patients with chronic pulmonary diseases is described as well as the advising of patients wishing to do sport by their own motivation or planning projects, for instance touristic ones, which require physical stress. PMID:8465532

  18. On the Role of Mechanics in Chronic Lung Disease

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    Mona Eskandari

    2013-12-01

    Full Text Available Progressive airflow obstruction is a classical hallmark of chronic lung disease, affecting more than one fourth of the adult population. As the disease progresses, the inner layer of the airway wall grows, folds inwards, and narrows the lumen. The critical failure conditions for airway folding have been studied intensely for idealized circular cross-sections. However, the role of airway branching during this process is unknown. Here, we show that the geometry of the bronchial tree plays a crucial role in chronic airway obstruction and that critical failure conditions vary significantly along a branching airway segment. We perform systematic parametric studies for varying airway cross-sections using a computational model for mucosal thickening based on the theory of finite growth. Our simulations indicate that smaller airways are at a higher risk of narrowing than larger airways and that regions away from a branch narrow more drastically than regions close to a branch. These results agree with clinical observations and could help explain the underlying mechanisms of progressive airway obstruction. Understanding growth-induced instabilities in constrained geometries has immediate biomedical applications beyond asthma and chronic bronchitis in the diagnostics and treatment of chronic gastritis, obstructive sleep apnea and breast cancer.

  19. Regional ventilation-perfusion ratio in chronic lung diseases measured with krypton-81m

    International Nuclear Information System (INIS)

    We measured regional ventilation-perfusion ratio (V radical/Q radical) by continuous inhalation of Kr-81 m and also continuous injection of Kr-81 m. The V radical/Q radical distribution can be divided four types. Type I is the normal pattern and V radical/Q radical value is the highest at apex. Type II has the highest V radical/Q radical value not at the apex but one third lower from the apex and the V radical/Q radical value gradually decreases towards the base. In type III V radical/Q radical has no gradient from the apex to the base. In type IV V radical/Q radical of the base higher than that of the apex. Most pulmonary emphysema show type I, most chronic bronchitis show type II and many interstitial pneumonia denote type IV. The ratio between the area in which the V radical/Q radical value was lower than 0.75, and the area of total lung (% 0.75) correlated with PaO2 (r = 0.59 p < 0.01). Coefficiency of variation (COV) of V radical/Q radical was larger in pulmonary emphysema and in interstitial pneumonia than in normal lung and COV of V radical/Q radical was the largest in chronic bronchitis. (author)

  20. Efficacy of Add-on Montelukast in Nonasthmatic Eosinophilic Bronchitis: The Additive Effect on Airway Inflammation, Cough and Life Quality

    Institute of Scientific and Technical Information of China (English)

    Wuping Bao; Ping Liu; Zhongmin Qiu; Li Yu; Jingqing Hang; Xiaohua Gao; Xin Zhou

    2015-01-01

    Background:The efficacy of montelukast (MONT),a cysteinyl leukotriene receptor antagonist,in nonasthmatic eosinophilic bronchitis (NAEB),especially its influence on cough associated life quality is still indefinite.We evaluated the efficacy of MONT combined with budesonide (BUD) as compared to BUD monotherapy in improving life quality,suppressing airway eosinophilia and cough remission in NAEB.Methods:A prospective,open-labeled,multicenter,randomized controlled trial was conducted.Patients with NAEB (aged 18-75 years) were randomized to inhaled BUD (200 μg,bid) or BUD plus oral MONT (10 μg,qn) for 4 weeks.Leicester cough questionnaire (LCQ) life quality scores,cough visual analog scale (CVAS) scores,eosinophil differential ratio (Eos),and eosinophil cationic protein (ECP) in induced sputum were monitored and compared.Results:The control and MONT groups contained 33 and 32 patients,respectively,with similar baseline characteristics.Significant with-in group improvement in CVAS,LCQ scores,Eos,and ECP was observed in both groups during treatment.After 2-week treatment,add-on treatment of MONT was significantly more effective than BUD monotherapy for CVAS decrease and LCQ scores improvement (both P < 0.05).Similar results were seen at 4-week assessment (both P < 0.05).4-week add-on therapy of MONT also resulted in a higher percentage of patients with normal sputum Eos (<2.5%) and greater decrease of ECP (both P < 0.05).Conclusions:MONT combined with BUD was demonstrated cooperative effects in improvement of life quality,suppression ofeosinophilic inflammation,and cough remission in patients with NAEB.

  1. Increased expression of Interleukin-6 related to nephritis in chickens challenged with an Avian infectious bronchitis virus variant

    Directory of Open Access Journals (Sweden)

    Filipe S. Fernando

    2015-03-01

    Full Text Available A Brazilian field isolate (IBV/Brazil/PR05 of avian infectious bronchitis virus (IBV, associated with development of nephritis in chickens, was previously genotyped as IBV variant after S1 gene sequencing. The aim of this study was to evaluate the levels of IL-6 in kidneys and trachea of birds vaccinated and challenged with IBV/Brazil/PR05 strain, correlating these results with scores of microscopic lesions, specific IBV antigen detection and viral load. The up-regulation of IL-6 and the increased levels of viral load on renal and tracheal samples were significantly correlated with scores of microscopic lesions. Reduced levels of viral load were detected in kidneys of birds previously vaccinated and challenged, compared to non-vaccinated challenged group, although markedly microscopic lesions were observed for both groups. The expression of IL-6, present both in the kidney and in the tracheas, was dependent on the load of the virus present in the tissue, and the development of lesions was related with IL-6 present in the tissues. These data suggest that variant IBV/Brazil/PR05 can induce the expression of proinflammatory cytokines in a manner correlated with viral load and increased IL-6 is involved in the tissue with the influx of inflammatory cells and subsequent nephritis. This may contribute with a model to the development of immunosuppressive agents of IL-6 to prevent acute inflammatory processes against infection with IBV and perhaps other coronaviruses, as well as contribute to the understanding of the immunopathogenesis of IBV nephropatogenic strains.

  2. Phylogeny and S1 Gene Variation of Infectious Bronchitis Virus Detected in Broilers and Layers in Turkey.

    Science.gov (United States)

    Yilmaz, Huseyin; Altan, Eda; Cizmecigil, Utku Y; Gurel, Aydin; Ozturk, Gulay Yuzbasioglu; Bamac, Ozge Erdogan; Aydin, Ozge; Britton, Paul; Monne, Isabella; Cetinkaya, Burhan; Morgan, Kenton L; Faburay, Bonto; Richt, Juergen A; Turan, Nuri

    2016-09-01

    The avian coronavirus infectious bronchitis virus (AvCoV-IBV) is recognized as an important global pathogen because new variants are a continuous threat to the poultry industry worldwide. This study investigates the genetic origin and diversity of AvCoV-IBV by analysis of the S1 sequence derived from 49 broiler flocks and 14 layer flocks in different regions of Turkey. AvCoV-IBV RNA was detected in 41 (83.6%) broiler flocks and nine (64.2%) of the layer flocks by TaqMan real-time RT-PCR. In addition, AvCoV-IBV RNA was detected in the tracheas 27/30 (90%), lungs 31/49 (62.2%), caecal tonsils 7/22 (31.8%), and kidneys 4/49 (8.1%) of broiler flocks examined. Pathologic lesions, hemorrhages, and mononuclear infiltrations were predominantly observed in tracheas and to a lesser extent in the lungs and a few in kidneys. A phylogenetic tree based on partial S1 sequences of the detected AvCoV-IBVs (including isolates) revealed that 1) viruses detected in five broiler flocks were similar to the IBV vaccines Ma5, H120, M41; 2) viruses detected in 24 broiler flocks were similar to those previously reported from Turkey and to Israel variant-2 strains; 3) viruses detected in seven layer flocks were different from those found in any of the broiler flocks but similar to viruses previously reported from Iran, India, and China (similar to Israel variant-1 and 4/91 serotypes); and 4) that the AVCoV-IBV, Israeli variant-2 strain, found to be circulating in Turkey appears to be undergoing molecular evolution. In conclusion, genetically different AvCoV-IBV strains, including vaccine-like strains, based on their partial S1 sequence, are circulating in broiler and layer chicken flocks in Turkey and the Israeli variant-2 strain is undergoing evolution. PMID:27610718

  3. Infectious bronchitis virus: dominance of ArkDPI-type strains in the United States broiler industry during the last decade

    Directory of Open Access Journals (Sweden)

    H Toro

    2010-06-01

    Full Text Available In the United States, more than 90% of chicken meat is produced in the southeastern states, and most egg production resides in the eastern half of the country and Texas. Several molecular epidemiological studies have indicated that most infectious bronchitis (IB virus (IBV isolates obtained from outbreaks of respiratory disease in these regions correspond to Ark-type IBV in spite of extensive vaccination programs which include IBV ArkDPI-derived vaccines. Accumulating evidence suggests that Ark-type strains may have a distinct capacity to circumvent preventive measures. Two strategies by which Ark-type IBV strains may maintain a high prevalence in commercial chickens are: (1 Unusually high genetic and phenotypic variability, and (2 synergism with concurrent viral immunodeficiency. Support for the first strategy includes epidemiological findings showing continued isolations of Ark-like viruses from respiratory disease affecting flocks vaccinated with serotype-specific homologous (ArkDPI-derived vaccines, experimental data demonstrating selection of new predominant phenotypes occurring rapidly after a single passage in the host, and recent findings indicating changes of the predominant IBV population occurring within the host during the invasion process. The second strategy is supported by epidemiological data indicating increased isolations of Ark-type IBV showing minor geno-/phenotypic variation occurring in chickens simultaneously affected by immunosuppressive viruses. In addition, experimental results have shown that viral immunodeficiency leads to more severe and prolonged IB signs and lesions, delayed and reduced specific antibody responses, and increased and persistent IBV shedding. Finally, accumulating evidence confirms high genetic and phenotypic heterogeneity in commercial ArkDPI-derived vaccines. The rapid selection of new predominant phenotypes occurring in these vaccines may be facilitating the emergence of Ark-like strains. Thus

  4. Bronquite plástica em criança com talassemia alfa Plastic bronchitis in a child with thalassemia alpha

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    Tiago N. Veras

    2005-12-01

    Full Text Available OBJETIVO: A bronquite plástica é uma doença infreqüente na criança, sendo caracterizada por moldes ou cilindros mucofibrinosos na árvore traqueobrônquica. Faz parte do diagnóstico diferencial de crianças com insuficiência respiratória de início agudo, e o tratamento precoce é importante para a resolução do quadro. O objetivo deste relato é descrever um caso de bronquite plástica tratado com sucesso por endoscopia, em paciente portador de talassemia alfa. DESCRIÇÃO: Criança do sexo masculino, 3 anos de idade, sem antecedentes mórbidos significativos, apresentou quadro de insuficiência respiratória aguda, com achados radiológicos de atelectasia pulmonar sugestivos de aspiração de corpo estranho. Não havia sintomas respiratórios ou antecedentes de alergia ou infecções respiratórias de repetição. A realização de broncoscopia flexível, complementada por endoscopia rígida e exame anatomopatológico, evidenciou a presença de bronquite plástica. Após a realização da endoscopia, a criança evoluiu satisfatoriamente, com curva térmica afebril e extubação em 72 horas. Foram utilizadas medicações sintomáticas, sem necessidade de antimicrobianos. Dez dias após a alta, a radiografia de tórax encontrava-se normal. A talassemia alfa foi diagnosticada através da eletroforese de hemoglobina. COMENTÁRIOS: A importância clínica da bronquite plástica reside no fato de apresentar um quadro semelhante ao de outras doenças mais prevalentes, como a aspiração de corpo estranho e a asma brônquica. A suspeita do quadro recomenda a realização de endoscopia para diagnóstico e tratamento. É reconhecida a ocorrência de bronquite plástica em crianças com fibrose cística, pós-operatório de cirurgia cardíaca e anemia falciforme. No presente artigo, foi observada uma associação com talassemia alfa.OBJECTIVE: Plastic bronchitis is an unusual condition in children, associated with formation of mucofibrinous

  5. Eotaxin in induced sputum in patients with asthma and eosinophilic bronchitis: relationship with airway inflammation%嗜酸细胞趋化因子在哮喘、嗜酸细胞性支气管炎患者诱导痰中的表达及其与气道炎症的关系

    Institute of Scientific and Technical Information of China (English)

    付杰伟; 蒋明彦; 欧阳繁

    2011-01-01

    目的 探讨嗜酸细胞趋化因子(eotaxin)在支气管哮喘、嗜酸细胞性支气管炎患者气道炎症发生中的作用以及在两者间的区别.方法 分别收集支气管哮喘(A组)、嗜酸细胞性支气管炎(EB组)、单纯慢性支气管炎(CB组)缓解期/稳定期患者13例、11例、12例和健康对照者(C组)9例.诱导痰并经处理后进行分类细胞记数,并用夹心法酶联免疫吸附测定(ELISA)其诱导痰上清液中eotaxin浓度.结果 诱导痰嗜酸细胞占白细胞百分比(Eos/Leu%)、eotaxin浓度A组[(19.2±9.7)%;(0.251±0.118)g/L]、EB组[(11.4±6.1)%;(0.146±0.079)g/L]分别与CB组[(0.9±0.6)%;(0.043±0.036)g/L]、C组[(0.8±0.4)%;(0.031±0.013)g/L]比较,差异有显著性(P均<0.05) ;A组Eos/Leu%、eotaxin浓度与EB组比较,差异也有显著性(P均<0.05).结论 eotaxin可能通过对 Eos的选择性趋化作用参与了支气管哮喘和嗜酸细胞性支气管炎患者气道炎症的发生机制,这种作用机制对于支气管哮喘和嗜酸细胞性支气管炎在程度上可能是不同的.%Objective Investigate the roles of eotaxin ( chemotactic factor of eosinophils) in pathogenesis of eosinophilic airway inflammation and the differences between ashma and eosinophilic brochitis.Methods 45 patients in stable phase with asthma (A group, 13 cases) ,eosinophilic bronchitis( EB group, 11 cases) ,chronic bronchitis( CB group, 12 cases) and and 9 healthy volunteers as controls( C group) had participated in sputum induction.The concentration of eotaxin in supematant was measured by sandwich enzyme linked immunosorbent assay( ELISA ).Results The differences of the eosinophil( Eos)/leukocyte( Leu ) % and the concentration of eotaxin in A group [(19.2±9.7)%;(0.251 ±0.118)g/L],EB group[(11.4±6.1)%;(0.146 ±0.079)g/L]between in CB group[(0.9 ±0.6) %;(0.043 ± 0.036 )g/L], C group [(0.8 ± 0.4 )%; (0.031 ± 0.013 ) g,/L]are significant ( P < 0.05 ).The differences of those in A group between in EB

  6. Effectiveness of anti-inflammatory treatment versus antibiotic therapy and placebo for patients with non-complicated acute bronchitis with purulent sputum. The BAAP Study protocol

    Directory of Open Access Journals (Sweden)

    Fernández Yvonne

    2011-06-01

    Full Text Available Abstract Background Acute bronchitis is one of the most prevalent respiratory infections in primary care, and in more than 90% of the cases antibiotics are prescribed, mainly when purulent expectoration is present. However, this process is usually viral in origin and the benefits of antibiotic treatment are marginal. On the other hand, in recent years bronchitis has been considered more as an inflammatory than an infectious process. Thus, the aim of this study is to evaluate the clinical effectiveness of a schedule of an oral anti-inflammatory compared with an antibiotic regimen and another group assigned to receive a placebo. Methods and design A total of 420 patients from 15 to 70 years of age with no associated comorbidity, presenting respiratory tract infection of at least one week of evolution, with cough as the predominant symptom, the presence of purulent expectoration and at least one other symptom of the respiratory tract (dyspnoea, wheezing, chest discomfort or pain, with no alternative explanation such as pneumonia, will be included in a prospective, randomised and controlled, clinical trial with placebo. The patients will be randomised to receive one of three treatments: ibuprofen, amoxycillin and clavulanic acid or placebo for 10 days. The main outcome measure is the number of days with frequent cough defined by the symptom diary with a score of 1 or more. Discussion This trial is designed to evaluate the number of days with frequent cough with anti-inflammatory treatment compared with antimicrobial treatment and placebo in previously healthy patients with a clinical picture of acute bronchitis and purulent expectoration. It is hypothesized that anti-inflammatory treatment is more effective than antibiotic treatment to reduce cough, which is the most disturbing symptom for patients with this infection. Trial registration ISRCTN07852892

  7. Chronic cholecystitis

    Science.gov (United States)

    ... foods may relieve symptoms in people. However, the benefit of a low-fat diet has not been proven. Alternative Names Cholecystitis - chronic Images Cholecystitis, CT scan Cholecystitis, cholangiogram Cholecystolithiasis Gallstones, cholangiogram Cholecystogram References Wang ...

  8. Chronic Meningitis

    Science.gov (United States)

    ... School Lunch Lines FDA Cracks Down on Antibacterial Soaps Health Tip: Schedule a Back-to-School Dental ... the Professional Version Meningitis Introduction to Meningitis Acute Bacterial Meningitis Viral Meningitis Noninfectious Meningitis Recurrent Meningitis Chronic ...

  9. Analysis of allergen detection results in children with acute bronchitis%急性支气管炎患儿血清过敏原检测分析

    Institute of Scientific and Technical Information of China (English)

    朱晓莉; 陶春妃

    2016-01-01

    Objective:To detect and analyze serum allergen of 87 children with acute bronchitis. Methods:87 patients with acute bronchitis were selected for serum allergen detection, and compared with the control group of 87 normal subjects ( no special al-lergic history). Results:For the 87 cases of children with acute bronchitis, the serum allergen test positive rate was 62. 07% (54/87);while for the control group, the serum specific allergen test positive rate was 17. 24% (15/87);and the difference was statisti-cally significant (P0. 05). The most common inhaled allergen was house dust mites/dust mites, accounting for 25. 29%, while the common ingested al-lergens were cod/lobster/scallops, crab, peanut, the proportion of 13. 79%, 18. 39% and 12. 64%, separately. Conclusions: For the children with acute bronchitis, the serum allergen detection has a higher positive detection rate, and is significant for the treatment and prevention.%目的::检测分析儿童急性支气管炎的血清过敏原。方法:将87例临床诊断为急性支气管炎患儿设为急性支气管炎组,选择87例同期健康儿童作为对照组,检测比较两组研究对象的血清过敏原。结果:急性支气管炎组患儿的血清过敏原检测阳性率为62.07%(54/87),与对照组儿童的血清特异性过敏原阳性率为17.24%(15/87)比,差异有统计学意义(P0.05);吸入性过敏原阳性率较高的为屋尘螨/粉尘螨,占比25.29%;食入性过敏原阳性率较高的是鳕鱼/龙虾/扇贝、螃蟹、花生,占比分别为13.79%、18.39%、12.64%。结论:儿童急性支气管炎血清过敏原检测具有较高的阳性检出率,对治疗和预防具有重要意义。

  10. FISHBURN’S METHOD: A METHOD OF DRUGS CLINICAL EFFICIENCY EVALUATION (ON THE EXAMPLE OF ANTIBIOTICS, APPLIED FOR THE TREATMENT OF ACUTE AND RECIDIVOUS OBSTRUCTIVE BRONCHITIS OF CHILDREN

    Directory of Open Access Journals (Sweden)

    O. V. Zhukova

    2015-01-01

    Full Text Available We have studied a structure of a therapy with antibiotics which is applied for patients with acute and recidivous obstructive bronchitis. We have determined a clinical efficiency of each antibiotic used. We have presented a methodology of weight coefficients calculation efficiency by the Fishburn’s method. We have also presented a method for antibiotics distribution by the levels of clinical efficiency – high, medium, and low.

  11. Effect of decimeter range waves in combination with drug electroaerosols on immunoinflammatory processes during chronic nonspecific lung diseases

    Energy Technology Data Exchange (ETDEWEB)

    Ayrapetova, N.S.; Tkachenko, A.F.

    An attempt was made to optimize the therapy of chronic nonspecific pulmonary diseases using a combination of decimeter range waves (DRW) and broncholytic electroaerosols. The electroaerosols penetrate rapidly deep into the lungs up to the aveoli, combining the action of an electric charge with the pharmaceutical effect. In all, 232 patients were studied (94.8% with chronic bronchitis, 5.2% with chronic pneumonia) manifesting an active inflammatory process, disturbance of the immune status and diminished glucocorticoid activity. After 15 procedures of combined therapy, 88.5% of the patients showed improvement in their clinical status; 65.4% of the control group (receiving only the electroaerosol) also showed improvement. In this combined therapy, the antiinflammatory and immunosuppressive effect were achieved due to the action of DRW; the electroaerosols had a positive effect on the function state of the cardiorespiratory system. 11 references.

  12. Gastro-esophageal reflux disease and exacerbations in chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Ingebrigtsen, Truls S; Marott, Jacob L; Vestbo, Jørgen;

    2015-01-01

    BACKGROUND AND OBJECTIVE: We tested the hypothesis that gastro-esophageal reflux disease is a risk factor for exacerbations in individuals with chronic obstructive pulmonary disease (COPD). METHODS: Among 9622 participants in the Copenhagen City Heart Study, we identified 1259 individuals with COPD...... and information on gastro-esophageal reflux disease and the regular use of acid inhibitory treatment. These individuals were followed for 5 years with regard to medically treated COPD exacerbations, which we defined as a short course treatment with oral corticosteroids alone or in combination with antibiotics. We...... applied a multivariable Cox regression analysis with adjustment for well-established risk factors associated with COPD exacerbations or gastro-esophageal reflux disease, including COPD severity, and symptoms. RESULTS: Individuals with COPD and gastro-esophageal reflux disease had more chronic bronchitis...

  13. Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Patel, Bipen D; Coxson, Harvey O; Pillai, Sreekumar G;

    2008-01-01

    RATIONALE: It is unclear whether airway wall thickening and emphysema make independent contributions to airflow limitation in chronic obstructive pulmonary disease (COPD) and whether these phenotypes cluster within families. OBJECTIVES: To determine whether airway wall thickening and emphysema (1...... severity of airway wall thickening and emphysema. MEASUREMENTS AND MAIN RESULTS: A total of 3,096 individuals were recruited to the study, of whom 1,159 (519 probands and 640 siblings) had technically adequate high-resolution computed tomography scans without significant non-COPD-related thoracic disease....... Airway wall thickness correlated with pack-years smoked (P < or = 0.001) and symptoms of chronic bronchitis (P < 0.001). FEV(1) (expressed as % predicted) was independently associated with airway wall thickness at a lumen perimeter of 10 mm (P = 0.0001) and 20 mm (P = 0.0013) and emphysema at -950...

  14. Protection conferred by a recombinant Marek’s disease virus that expresses the spike protein from infectious bronchitis virus in specific pathogen-free chicken

    Directory of Open Access Journals (Sweden)

    Zhang Xiaorong

    2012-05-01

    Full Text Available Abstract Background In many countries, the predominant field isolates of infectious bronchitis virus (IBV have been classified as QX-like strains since 1996. However, no commercial vaccines that are specific for this type of IBV are currently available. Therefore, there is an urgent need to develop novel vaccines that prevent QX-like IBV infection. Results A recombinant Marek’s disease virus (MDV, rMDV-S1, that expresses the S1 subunit of the spike (S protein from the QX-like infectious bronchitis virus (IBV was constructed by inserting the IBV S1 gene into the genome of the CVI988/Rispens strain of MDV. Specific pathogen-free (SPF chickens that were vaccinated with rMDV-S1 were protected when challenged with the QX-like IBV. They were observed to have mild clinical signs of disease, a short virus-shedding period and low mortality. Additionally, the rMDV-S1 conferred full protection to chickens against virulent MDV, as did the CVI988/Rispens strain. Conclusions Our results demonstrate that rMDV-S1 is an effective and promising recombinant vaccine for the prevention of QX-like IBV infection.

  15. Valuing the Economic Costs of Allergic Rhinitis, Acute Bronchitis, and Asthma from Exposure to Indoor Dampness and Mold in the US.

    Science.gov (United States)

    Mudarri, David H

    2016-01-01

    Two foundational methods for estimating the total economic burden of disease are cost of illness (COI) and willingness to pay (WTP). WTP measures the full cost to society, but WTP estimates are difficult to compute and rarely available. COI methods are more often used but less likely to reflect full costs. This paper attempts to estimate the full economic cost (2014$) of illnesses resulting from exposure to dampness and mold using COI methods and WTP where the data is available. A limited sensitivity analysis of alternative methods and assumptions demonstrates a wide potential range of estimates. In the final estimates, the total annual cost to society attributable to dampness and mold is estimated to be $3.7 (2.3-4.7) billion for allergic rhinitis, $1.9 (1.1-2.3) billion for acute bronchitis, $15.1 (9.4-20.6) billion for asthma morbidity, and $1.7 (0.4-4.5) billion for asthma mortality. The corresponding costs from all causes, not limited to dampness and mold, using the same approach would be $24.8 billion for allergic rhinitis, $13.5 billion for acute bronchitis, $94.5 billion for asthma morbidity, and $10.8 billion for asthma mortality. PMID:27313630

  16. Valuing the Economic Costs of Allergic Rhinitis, Acute Bronchitis, and Asthma from Exposure to Indoor Dampness and Mold in the US

    Directory of Open Access Journals (Sweden)

    David H. Mudarri

    2016-01-01

    Full Text Available Two foundational methods for estimating the total economic burden of disease are cost of illness (COI and willingness to pay (WTP. WTP measures the full cost to society, but WTP estimates are difficult to compute and rarely available. COI methods are more often used but less likely to reflect full costs. This paper attempts to estimate the full economic cost (2014$ of illnesses resulting from exposure to dampness and mold using COI methods and WTP where the data is available. A limited sensitivity analysis of alternative methods and assumptions demonstrates a wide potential range of estimates. In the final estimates, the total annual cost to society attributable to dampness and mold is estimated to be $3.7 (2.3–4.7 billion for allergic rhinitis, $1.9 (1.1–2.3 billion for acute bronchitis, $15.1 (9.4–20.6 billion for asthma morbidity, and $1.7 (0.4–4.5 billion for asthma mortality. The corresponding costs from all causes, not limited to dampness and mold, using the same approach would be $24.8 billion for allergic rhinitis, $13.5 billion for acute bronchitis, $94.5 billion for asthma morbidity, and $10.8 billion for asthma mortality.

  17. Bronquite infecciosa das galinhas: conhecimentos atuais, cepas e vacinas no Brasil Infectious bronchitis of chickens: current knowledge, strains and vaccines in Brazil

    Directory of Open Access Journals (Sweden)

    Juliana Figueiredo Pitangui Mendonça

    2009-11-01

    Full Text Available A bronquite infecciosa das galinhas (IB é uma doença viral aguda e altamente contagiosa que provoca grandes perdas econômicas à indústria avícola em todo o mundo. Considerando que surtos têm ocorrido no Brasil com emergência de novas variantes de IBV, desafiando as estratégias de vacinação atuais, este trabalho objetiva revisar os conhecimentos sobre IB e IBV, a sua distribuição, as cepas e as vacinas utilizadas no Brasil.Infectious bronchitis (IB is an acute, highly contagious disease of chickens, caused by infectious bronchitis virus (IBV, which results in great economic losses to the poultry industry worldwide, despite the routine use of vaccines. Several outbreaks do occur periodically in densely populated poultry regions in Brazil and there are constant emergence of new variants. The aim of this paper is to review the current knowledge about IBV and IB, the distribution, strains and vaccines in Brazil.

  18. Comparison of sequences of hypervariable region (HVR subunit S-1 gene of field isolate I-37 infectious bronchitis virus with Connecticut serotype

    Directory of Open Access Journals (Sweden)

    N.L.P Indi Dharmayanti

    2003-06-01

    Full Text Available Infectious Bronchitis is a contagious and acute respiratory disease in chickens caused by infectious bronchitis virus (IBV.Antigenic differences in IBV are associated with changes in the sequence of the spike glycoprotein (S. The subunit S1 which demonstrates more sequence variability than S-2 have been identified as hypervariable region (HVR-1 and 2. There were several IB virus field isolates included I-37 have been identified in Indonesia by serum neutralization method. However, gene sequence variation in HVR subunit S-1 had not yet been identified. Isolate I-37 was close to the serotype Connecticut 46 (Conn 46. The aim of this study is to identify sequence variation of HVR subunit S-1 gene of isolate I-37 produced by Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR and sequencing. Several procedures were carried out in the study including virus titration, propagation and was concentrated from the allantoic fluid infected with IBV. Then, RNA was extracted for RTPCR. urther the product was sequnced and its homology with IBV references from GenBank was compared by GenMac version 8.0. Result showed that isolate I-37 produced 515 bp of amplification product. Isolate I-37 and Conn 46 are same serotype, yet their HVR subunit S-1 nucleotides and amino acids (protein differ by 6.9% and 15.6% respectively. It might be concluded that isolate I-37 was variant of Conn 46.

  19. Evolutionary and bioinformatic analysis of the spike glycoprotein gene of H120 vaccine strain protectotype of infectious bronchitis virus from India.

    Science.gov (United States)

    Kamble, Nitin Machindra; Pillai, Aravind S; Gaikwad, Satish S; Shukla, Sanjeev Kumar; Khulape, Sagar Aashok; Dey, Sohini; Mohan, C Madhan

    2016-01-01

    The infectious bronchitis virus is a causative agent of avian infectious bronchitis (AIB), and is is an important disease that produces severe economic losses to the poultry industry worldwide. Recent AIB outbreaks in India have been associated with poor growth in broilers, drop in egg production, and thin egg shells in layers. The complete spike gene of Indian AIB vaccine strain was amplified and sequenced using a conventional reverse transcription polymerase chain reaction and is submitted to the GenBank (accession no KF188436). Phylogenetic analysis revealed that the vaccine strain currently used belongs to H120 genotype, an attenuated strain of Massachusetts (Mass) serotype. Nucleotide and amino acid sequence comparisons have shown that the reported spike gene from Indian isolates have 71.8%-99% and 71.4%-96.9% genetic similarity with the sequenced H120 strain. The study identifies live attenuated IBV vaccine strain, which is routinely used for vaccination, for the first time. Based on nucleotide and amino acid relatedness studies of the vaccine strain with reported IBV sequences from India, it is shown that the current vaccine strain is efficient in controlling the IBV infection. Continuous monitoring of IBV outbreaks by sequencing for genotyping and in vivo cross protection studies for serotyping is not only important for epidemiological investigation but also for evaluation of efficacy of the current vaccine. PMID:25311758

  20. Chronic myelogenous leukemia (CML)

    Science.gov (United States)

    CML; Chronic myeloid leukemia; Chronic granulocytic leukemia; Leukemia - chronic granulocytic ... nuclear disaster. It takes many years to develop leukemia from radiation exposure. Most people treated for cancer ...

  1. Chronic Respiratory Apparatus Diseases by Dog-day Moxibustion%三伏灸治疗慢性呼吸道疾病的疗效观察

    Institute of Scientific and Technical Information of China (English)

    艾宙; 刘媛媛; 奚玉风; 张倩如; 邹婷; 陈瑞; 方焕奎

    2011-01-01

    目的:观察慢性呼吸道疾病如慢性咽炎、过敏性鼻炎、慢性单纯性鼻炎、慢性支气管炎(缓解期)、支气管哮喘(缓解期)应用三伏灸的疗效,探讨三伏灸疗法对多种常见慢性呼吸道疾病的优势病种.方法:在每年确定的三伏天时间内,将"天灸膏"药粉配适量蜂蜜和新鲜姜汁调和,制成软膏状,将药物敷贴固定在相关穴位.结果:慢性单纯性鼻炎疗程越长则疗效越好;过敏性鼻炎、慢性咽炎见效稍缓;慢性支气管炎和哮喘则起效较快、疗效相对稳定.%Objective: To observe the effects of natural moxibustion in dogdays on chronic respiratory apparatus disease, such as chronic pharyngitis, allergic rhnitis, chronic simple rhinitis, chronic bronchitis (in remission), bronchial asthma( in remssion).Find out the advantage effect of these chronic respiratory apparatus diseases.Methods: In the specified dog days each year, stick ointmeat of natural moxibustion which is mixed with suitable amount of honey and fresh ginger on the related points.Results:The effect on chronic simple rhinitis is connected with the time of natural moxibustion in dogdays.Conclusion :The effects on allergic coryza and chronic pharyngitis are slow.The effects on chronic bronchitis and Asthma are much more obvious than others.

  2. Chyloptysis causing plastic bronchitis

    Directory of Open Access Journals (Sweden)

    Alice Stoddart

    2014-01-01

    Full Text Available Chyloptysis is a rare clinical problem that is associated with conditions affecting lymphatic channels in the thorax. Diagnosis is usually made when the patients present with expectoration of milky-white sputum or of thick tenacious mucus in the shape of smaller bronchi (bronchial cast. Typically the symptoms resolve after coughing up of the bronchial casts. Pleural, mediastinal, pulmonary or lymphatic abnormalities result in chyloptysis. Lymphangiography and detection of lipids (cholesterol or triglycerides in sputum help to establish the diagnosis. However, lymphangiography may not be positive in all patients. We report 2 patients with chyloptysis and bronchial casts with different etiologies. Abnormal lymphatics were demonstrated in one of our cases, but the second patients lymphangiogram was normal. In this patient we suspect that high venous filling pressures due to congestive heart failure had a causative effect in the setting of compromised lymphatic drainage in the thorax due to a prior history of radiation therapy to the chest for lymphoma.

  3. Occupational causes of chronic obstructive pulmonary disease.

    Science.gov (United States)

    Rushton, Lesley

    2007-01-01

    The relation between Chronic Obstructive Pulmonary Disease (COPD, including chronic bronchitis and emphysema (CBE), and exposure to coal dust is well established. This paper reviews the evidence relating to other occupational causes of COPD, including industries associated with exposure to fumes, chemical substances, and dusts. A review of key literature has been carried out with a focus on the magnitude of risks and levels of exposure causing disabling health effects. The literature suggests that elevated risks of developing COPD are clearly associated with several occupations, with risk estimates being high in some, even after taking into account the effect of confounders, such as smoking. Of particular concern are agricultural workers who can be exposed to a variety of gases and organic dusts, among whom CBE is clearly elevated, particularly for pig farmers and exposure to endotoxins, with an increased annual decline in lung function. Similarly, cotton textile workers are exposed to a mixture of substances affecting development of atopy, byssinosis, and CBE, and across-shift and long-term decline in lung function. Atopy also has an important role in the development of COPD in flour mill workers and bakers, with those sensitized to bakery allergens having a greater lung function decline than non-sensitized individuals. Welding processes involve a range of potential chemical, physical and radiation hazards. The average reduction in FEV1 associated with welding fumes is similar to that associated with smoking. Challenges in assessing the evidence include variation in diagnostic methods; concurrent exposure to cigarette smoke (direct or second-hand) and multiple work-place irritants; healthy worker selection/survivor effects; poor exposure definition. Raising awareness of occupational causes of COPD among employers, employees, and health service professionals is important.

  4. Chronic pain - resources

    Science.gov (United States)

    Pain - resources; Resources - chronic pain ... The following organizations are good resources for information on chronic pain: American Chronic Pain Association -- www.theacpa.org National Fibromyalgia and Chronic Pain Association -- www.fmcpaware.org ...

  5. Low back pain - chronic

    Science.gov (United States)

    Nonspecific back pain; Backache - chronic; Lumbar pain - chronic; Pain - back - chronic; Chronic back pain - low ... Low back pain is common. Almost everyone has back pain at some time in their life. Often, the exact cause ...

  6. Chronic motor tic disorder

    Science.gov (United States)

    Chronic vocal tic disorder; Tic - chronic motor tic disorder ... Chronic motor tic disorder is more common than Tourette syndrome . Chronic tics may be forms of Tourette syndrome. Tics usually start ...

  7. Chronic Pelvic Pain

    Science.gov (United States)

    ... Events Advocacy For Patients About ACOG Chronic Pelvic Pain Home For Patients Search FAQs Chronic Pelvic Pain ... Pain FAQ099, August 2011 PDF Format Chronic Pelvic Pain Gynecologic Problems What is chronic pelvic pain? What ...

  8. Employees with Chronic Pain

    Science.gov (United States)

    ... Home | Accommodation and Compliance Series: Employees with Chronic Pain By Beth Loy, Ph.D. Preface Introduction Information ... at http://AskJAN.org/soar. Information about Chronic Pain How prevalent is chronic pain? Chronic pain has ...

  9. 阿奇霉素门诊治疗急性支气管炎疗效分析%The Efficacy of Azithromycin for Acute Bronchitis Outpatient

    Institute of Scientific and Technical Information of China (English)

    赵海伶

    2011-01-01

    目的:探讨阿奇霉素门诊治疗急性支气管炎的有效性.方法:选择142例门诊急性支气管炎患者,分为两组,青霉素组应用青霉素静脉640万单位/d静滴,阿奇霉素组应用阿奇霉素500mg加入0.9%生理盐水250mL静滴,Qd,1个疗程时,比较两组患者临床症状改善时间,确定患者临床痊愈时间和影像学痊愈时间,评价患者治疗效果.结果:阿奇霉素组咳嗽咳痰时间以及咽痛改善时间明显快于青霉素组,呼吸困难和发热改善时间差异无统计学意义,阿奇霉素组显效率明显优于青霉素治疗组,阿奇霉素组临床痊愈时间和影像学痊愈时间均明显优于青霉素组.结论:门诊急性支气管炎患者,应用阿奇霉素起效迅速,对咳嗽咳痰和咽痛改善明显,总临床疗效优于青霉素.%Objective: To investigate the azithromycin effectiveness of acute bronchitis outpatient.Method: 142 patients with acute bronchitis each were divided into two groups, penicillin group received intravenous penicillin 6.4 million units each day intravenously 500rug azithromycin were added into 250mL 0.9% saline infusion, Qd, 1 course of treatment, the Comparison of clinical symptoms improved time to determine the clinical recovery time and then evaluated patient outcomes. Result: The time of azithromycin and sore throat, cough and expectoration improve the time was faster than the penicillin group, dyspnea, and fever to improve the time difference was not statistically significant, the efficiency of azithromycin group was significantly superior to penicillin treatment group, clinical cure azithromycin group and imaging time recovery time were significantly better than the penicillin group. Conclusion: The patient with acute bronchitis,the application of azithromycin rapid onset of cough and expectoration and sore throat are significantly improved, the total clinical effective are more valider than penicillin.

  10. Chronic coughing

    International Nuclear Information System (INIS)

    Chronic coughing was acknowledged to result from pathological state of the respiratory organs. Cardiac diseases could be accompanied by coughing as well. It was recommended to perform x-ray examinations, including biomedical radiography of the chest, computerized tomography, scintiscanning with 67Ga-citrate, bronchi examination in order to exclude heart disease. The complex examination permitted to detect localization and type of the changes in the lungs and mediastinum, to distinguish benign tumor from malignant one

  11. Detection and strain differentiation of infectious bronchitis virus in tracheal tissues from experimentally infected chickens by reverse transcription-polymerase chain reaction. Comparison with an immunohistochemical technique

    DEFF Research Database (Denmark)

    Handberg, Kurt; Nielsen, O.L.; Pedersen, M.W.;

    1999-01-01

    Oligonucleotide pairs were constructed for priming the amplification of fragments of nucleocapsid (N) protein and spike glycoprotein (S) genes of avian infectious bronchitis virus (IBV) by reverse transcription-polymerase chain reaction (RT-PCR). One oligonucleotide pair amplified a common segment......3896 and 793B strains of IBV, respectively, Groups of specific pathogen free chickens were experimentally inoculated with the Massachusetts (H120, M41), the D1466 and the 793B strains of IBV, and tracheal tissue preparations were made from each bird for RT-PCR and for immunohistochemistry (IHC) up to 3...... days post-inoculation. The N-gene RT-PCR detected IBV in 82% of the chickens, while IHC only detected IBV in 60%. This difference was significant (P PCR varied from 67 to 100% for the various strains of IBV inoculated. The S1 gene oligonucleotide pairs were...

  12. Prevalence of Newcastle disease virus and infectious bronchitis virus in avian influenza negative birds from live bird markets and backyard and commercial farms in Ivory-Coast.

    Science.gov (United States)

    Kouakou, A V; Kouakou, V; Kouakou, C; Godji, P; Kouassi, A L; Krou, H A; Langeois, Q; Webby, R J; Ducatez, M F; Couacy-Hymann, E

    2015-10-01

    Newcastle disease (ND) and infectious bronchitis (IB) are two major viral diseases affecting the respiratory tracts of birds and whose impact on African poultry is still poorly known. In the present study we aimed at assessing NDV and IBV prevalences in Ivory-Coast by molecular screening of >22,000 avian swabs by nested PCR and by serology testing of close to 2000 avian sera from 2010 through 2012. The NDV and IBV seroprevalences over the study period reached 22% and 72%, respectively. We found 14.7% pooled swabs positive by PCR for NDV and 14.6% for IBV. Both pathogens are therefore endemic in Ivory-Coast. Economic losses associated with NDV and IBV infections still need to be evaluated.

  13. Prevalence of chronic obstructive pulmonary disease among adult male cigarettes smokers: a community-based study in Jordan

    Directory of Open Access Journals (Sweden)

    Al Omari M

    2014-07-01

    Full Text Available Mousa Al Omari,1 Basheer Y Khassawneh,2 Yousef Khader,1 Ali Shakir Dauod,1 George Bergus3 1Department of Community Medicine, Public Health and Family Medicine, Faculty of Medicine, Jordan University of Science and Technology, 2Department of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan; 3Department of Family Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA Abstract: Chronic obstructive pulmonary disease (COPD is a leading cause of morbidity and mortality worldwide. The prevalence of COPD among cigarette smokers in the Middle East is not well studied. A prospective descriptive study was performed in the north of Jordan. Male cigarette smokers (≥10 pack-year aged 35 years and older were recruited from the community. They completed a questionnaire and a postbronchodilator spirometry. Global Initiative for Chronic Obstructive Lung Disease (GOLD criteria (postbronchodilator forced expiratory volume in 1 second <70% was used to define COPD. A total of 512 subjects completed the study protocol. According to the GOLD criteria, 42 subjects (8.2% had COPD. Of those, 27 subjects (64.3% had symptomatic COPD. Using the GOLD criteria, eight subjects (19% with COPD had mild disease, 24 (57.1% had moderate disease, eight (19% had severe disease, and two (4.8% had very severe disease. Only 10.6% were aware of COPD as a smoking-related respiratory illness, and 6.4% had received counseling about risk for COPD by a physician. Chronic bronchitis (cough for 3 months in 2 consecutive years was reported by 15% of the subjects, wheezes by 44.1%, and dyspnea by 65.2%. Subjects with COPD reported having more chronic bronchitis 18/42 (42.9% and wheezing 28/42 (66.7% than subjects without COPD. The prevalence of COPD increased with increased number of pack-years smoked. In conclusion, COPD prevalence among cigarette-smoking men in Jordan is lower than in the developed world. COPD was largely

  14. Advances in the diagnosis and treatment of children with plastic bronchitis%儿童塑型性支气管炎诊疗进展

    Institute of Scientific and Technical Information of China (English)

    张雪

    2013-01-01

    儿童塑型性支气管炎是一种较罕见的疾病,病因不明,起病隐匿,进展快,症状重,诊断和治疗难度大,病死率高.儿童塑型支气管炎被认为与某些疾病包括支气管哮喘、囊性纤维病、伴发急性胸部综合征的镰状细胞病、先天性心脏病以及各种呼吸道细菌性和病毒性感染有一定关系.关于儿童塑型性支气管炎的诊断和治疗目前仍较困难,临床医生应该警惕该病,做到早期诊断、早期治疗.%Children with plastic bronchitis,characterized by unknown origin,insidious onset,rapid progress,severe symptom and high mortality,is a relatively rare disease.Also,it is difficult to diagnose and treat with plastic bronchitis characterized by marked airway obstruction,via the formation of large gelatinous or rigid airway cast.It is associated with certain diseases including bronchial asthma,cystic fibrosis,accompanied with acute chest syndrome with sickle cell disease,congenital heart disease and bacterial and viral respiratory infection.Clinicians should be aware of this disease,and early bronchoscopy should be intervened.

  15. Chronic Insomnia

    OpenAIRE

    Buysse, Daniel J.

    2008-01-01

    Ms. F, a 42-year-old divorced woman, presents for evaluation of chronic insomnia. She complains of difficulty falling asleep, often 30 minutes or longer, and difficulty maintaining sleep during the night, with frequent awakenings that often last 30 minutes or longer. These symptoms occur nearly every night, with only one or two “good” nights per month. She typically goes to bed around 10:00 p.m. to give herself adequate time for sleep, and she gets out of bed around 7:00 a.m. on work days and...

  16. Chronic kidney disease

    Science.gov (United States)

    Kidney failure - chronic; Renal failure - chronic; Chronic renal insufficiency; Chronic kidney failure; Chronic renal failure ... 2012_CKD_GL.pdf . McCullough PA. Interface between renal disease ... patients with kidney failure. N Engl J Med . 2010;362(14):1312- ...

  17. Atypical Chronic Myelogenous Leukemia

    Science.gov (United States)

    ... myeloproliferative neoplasms, leukemia , and other conditions . Chronic Myelomonocytic Leukemia Key Points Chronic myelomonocytic leukemia is a disease ... chance of recovery) and treatment options. Chronic myelomonocytic leukemia is a disease in which too many myelocytes ...

  18. 小儿肺咳颗粒对急性小儿支气管炎治疗的临床观察%Clinical Effects of Pediatric Lung Cough Particles on Acute Bronchitis in Children

    Institute of Scientific and Technical Information of China (English)

    王晴晴; 过桥

    2014-01-01

    Objective:To study the clinical effects of Pediatric Lung Cough Particles on acute bronchitis in children.Method:280 patients with acute bronchitis from July 2012 to July 2014 in our hospital were studied.The patients were randomly divided into two groups,the observation group,200 cases (Pediatric Lung Cough Particles),and the control group,80 cases (cefotaxime by intravenous dripping).The clinical symptoms,clinical signs and symptoms score to quantify adverse reactions were observed. A course of treatment to determine efficacy.Result:The clinical signs and symptoms score of the two groups were all significantly reducing(P0.05)。结论:小儿肺咳颗粒治疗急性小儿支气管炎有显著效果,值得在临床上推广。

  19. Chronic mucus hypersecretion

    DEFF Research Database (Denmark)

    Harmsen, L; Thomsen, S F; Sylvan Ingebrigtsen, Truls;

    2010-01-01

    Chronic mucus hypersecretion (CMH) is a common condition in patients with chronic respiratory diseases. Little is known about the incidence, prevalence and determinants of CMH in younger individuals....

  20. Treating 50 cases of acute bronchitis in children with Zhisou powder plus Sanzi Yangqin decoction%止嗽散合三子养亲汤治疗小儿急性支气管炎50例

    Institute of Scientific and Technical Information of China (English)

    王云蝶; 孙真香

    2014-01-01

    Objective: To observe the efficacy on treating acute bronchitis in children with Zhisou powder plus Sanzi Yangqin decoction. Methods: 50 cases of acute bronchitis in children treated with Zhisou powder plus Sanzi Yangqin decoction, statistical effect after 7 days. Results:39 cases were cured, 7 cases improved, 4 cases ineffective, the total efficiency was 92%. Conclusion:Zhisou powder plus Sanzi Yangqin decoction is effective on treating acute bronchitis in children, worthy of a wide clinical application.%目的:观察止嗽散合三子养亲汤治疗小儿急性支气管炎的疗效。方法:将50例急性支气管炎患儿予止嗽散合三子养亲汤7d后统计疗效。结果:治愈39例,好转7例,未愈4例,总有效率92%。结论:采用止嗽散合三子养亲汤治疗小儿急性支气管炎,疗效显著,值得临床推广应用。

  1. Chronic urticaria

    Directory of Open Access Journals (Sweden)

    Sandeep Sachdeva

    2011-01-01

    Full Text Available Chronic urticaria (CU is a disturbing allergic condition of the skin. Although frequently benign, it may sometimes be a red flag sign of a serious internal disease. A multitude of etiologies have been implicated in the causation of CU, including physical, infective, vasculitic, psychological and idiopathic. An autoimmune basis of most of the ′idiopathic′ forms is now hypothesized. Histamine released from mast cells is the major effector in pathogenesis and it is clinically characterized by wheals that have a tendency to recur. Laboratory investigations aimed at a specific etiology are not always conclusive, though may be suggestive of an underlying condition. A clinical search for associated systemic disease is strongly advocated under appropriate circumstances. The mainstay of treatment remains H1 antihistaminics. These may be combined with complementary pharmacopeia in the form of H2 blockers, doxepin, nifedipine and leukotriene inhibitors. More radical therapy in the form of immunoglobulins, plasmapheresis and cyclophosphamide may be required for recalcitrant cases. Autologous transfusion and alternative remedies like acupuncture have prospects for future. A stepwise management results in favorable outcomes. An update on CU based on our experience with patients at a tertiary care centre is presented.

  2. Prevalence and global initiative for chronic obstructive lung disease group distribution of chronic obstructive pulmonary disease detected by preoperative pulmonary function test.

    Directory of Open Access Journals (Sweden)

    Sun Mi Choi

    Full Text Available Despite being a major public health problem, chronic obstructive pulmonary disease (COPD remains underdiagnosed, and only 2.4% COPD patients are aware of their disease in Korea. The objective of this study was to estimate the prevalence of COPD detected by spirometry performed as a preoperative screening test and to determine the Global Initiative for Chronic Obstructive Lung Disease (GOLD group distribution and self-awareness of COPD.We reviewed the medical records of adults (age, ≥ 40 years who had undergone spirometry during preoperative screening between April and August 2013 at a tertiary hospital in Korea. COPD was defined as a postbronchodilator forced expiratory volume in 1 s/forced vital capacity ratio of 40 years who had undergone spirometry as a preoperative screening test, 474 (15.6%; 404 men; median age, 70 years; range, 44-93 years were diagnosed with COPD. Only 26 (5.5% patients reported previous diagnosis of COPD (2.1%, emphysema (0.8%, or chronic bronchitis (2.5%. The GOLD group distribution was as follows: 63.3% in group A, 31.2% in group B, 1.7% in group C, and 3.8% in group D.The prevalence of COPD diagnosed by preoperative spirometry was 15.6%, and only 5.5% patients were aware of their disease. Approximately one-third of the COPD patients belonged to GOLD groups B, C, and D, which require regular treatment.

  3. A STUDY ON CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD PATIENTS WITH REFERENCE TO ECHOCARDIOGRAPHIC FINDINGS

    Directory of Open Access Journals (Sweden)

    Uma Sankar

    2015-12-01

    Full Text Available BACKGROUND Chronic Obstructive Pulmonary Disease (COPD is a common and preventable disease, which has great implication on global health. It is acknowledged by WHO as a commonest cause of death worldwide. The major morbidity of COPD is due to its impact on cardiac performance. Right ventricular dysfunction is common in patients with COPD. Echocardiogram is a very simple and convenient bedside investigation to detect cardiac function and structure. OBJECTIVE To study the clinical profile, echocardiographic findings of COPD patients and to correlate the echocardiographic findings with the severity of the disease. MATERIAL METHOD A total of 100 patients admitted in the Department of Medicine of Silchar Medical College during the period from June 2013 to May 2014 were selected and detailed clinical examination, pulmonary funtion test, Chest X-Ray, ECG and Echocardiogram were done in all cases. RESULT Mean age of the patients was 61+8.6 years and highest 46% were in the age group of 61 to 70 years and 86% were male. Highest number 64% were farmers residing in rural area (83%; 89% of patients were smoker presented with cough (97%, expectoration of sputum (93% and dyspnoea (91%. The patient had pedal oedema (65%, raised JVP (56% and cynosis (43%. In 94% pulmonary rales, 79% use of accessory muscle of respiration, 74% ronchi and 52% barrel shaped chest was found. In chest X-ray 49% had chronic bronchitis and another 49% emphysema. Pulmonary function test revealed severe obstruction in 50% and moderate obstruction in 46%. ECG revealed P-Pulmonale (51%, Right axis deviation (45%, RVH (39% and RBBB (31%. Echocardiogram shows dilated right ventricle (53%, Pulmonary hypertension (53%, right atrial enlargement (42% and right ventricular hypertrophy (26%. In the moderate severe COPD 32.60% (15 out of 46 had dilatation of right ventricle and pulmonary hypertension. Only 8.69% had right atrial enlargement. In severe group 76% had right atrial enlargement

  4. Neuromodulation of chronic headaches

    DEFF Research Database (Denmark)

    Martelletti, Paolo; Jensen, Rigmor H; Antal, Andrea;

    2013-01-01

    The medical treatment of patients with chronic primary headache syndromes (chronic migraine, chronic tension-type headache, chronic cluster headache, hemicrania continua) is challenging as serious side effects frequently complicate the course of medical treatment and some patients may be even...

  5. Molecular detection of infectious bronchitis virus and it is relation with avian influenza virus (H9 and Mycoplasma gallisepticum from different geographical regions in Iraq

    Directory of Open Access Journals (Sweden)

    A.H. Al-Dabhawe

    2013-12-01

    Full Text Available Infectious bronchitis virus (IBV, Avian influenza virus (AIV and Mycoplasma gallisepticum (MG have been recognized as the most important pathogens in poultry cause acute respiratory infection and serous economic problems in Iraq and many other countries all over the world. This study was conducted to investigate the distribution of these diseases in commercial chicken flocks in different geographical region in middle part of Iraq by using qPCR. Tracheal swabs and tissue specimens from trachea, lung and kidney were taken from 38 different cases from commercial broiler chicken flocks in (Najaf, Hilla, Muthana and Theqaar governorates in the period from November 2010 to June 2011, all these flocks were showed respiratory symptoms and mortality about 20-90%. The results showed that 92.1% of samples collected from these flocks were infected with IBV, 20% of samples were infected with IB alone and 45.71% of samples with IB combined with both GM and AIV subtype H9 and 25.71% of samples were positive to both IBV and AIV(H9. No samples were positive to AIV (H9 or MG alone. Because of importance of respiratory diseases as a most common conditions noted in commercial flocks in Iraq and no previous study detecting this pathogens by molecular techniques, this study come to detect and confirm the diagnosis of this pathogens by qPCR as new technique used in this field in Iraq.

  6. Inhaler use in adolescents and adults with self-reported physician-diagnosed asthma, bronchitis, or emphysema in the city of Pelotas, Brazil

    Directory of Open Access Journals (Sweden)

    Paula Duarte de Oliveira

    2013-06-01

    Full Text Available OBJECTIVE: To evaluate the characteristics of users of inhalers and the prevalence of inhaler use among adolescents and adults with self-reported physician-diagnosed asthma, bronchitis, or emphysema. METHODS: A population-based study conducted in the city of Pelotas, Brazil, involving 3,670 subjects ≥ 10 years of age, evaluated with a questionnaire. RESULTS: Approximately 10% of the sample reported at least one of the respiratory diseases studied. Among those individuals, 59% reported respiratory symptoms in the last year, and, of those, only half reported using inhalers. The use of inhalers differed significantly by socioeconomic status (39% and 61% for the lowest and the highest, respectively, p = 0.01. The frequency of inhaler use did not differ by gender or age. Among the individuals reporting emphysema and inhaler use, the use of the bronchodilator-corticosteroid combination was more common than was that of a bronchodilator alone. Only among the individuals reporting physician-diagnosed asthma and current symptoms was the proportion of inhaler users higher than 50%. CONCLUSIONS: In our sample, inhalers were underutilized, and the type of medication used by the individuals who reported emphysema does not seem to be in accordance with the consensus recommendations.

  7. [Pelargonium sidoides in acute bronchitis - Health-related quality of life and patient-reported outcome in adults receiving EPs 7630 treatment].

    Science.gov (United States)

    Matthys, Heinrich; Lizogub, Victor G; Funk, Petra; Malek, Fathi A

    2010-12-01

    Health-related quality of life (HRQL) and patient-reported outcome (PRO) have become important outcome parameters for the evaluation of medical treatment within clinical trials and, furthermore, to evaluate efficiency in clinical practice. We therefore report further exploratory results of an already reported dose-finding study with EPs 7630 tablets, now focussing on HRQL and PRO. A total of 406 adults with acute bronchitis were randomly assigned to one of four parallel treatment groups (placebo, 30 mg, 60 mg or 90 mg EPs 7630 daily). HRQL and PRO were assessed by questionnaires as secondary outcome measures at each study visit or daily in the patient's diary. At day 7, the patient-reported outcome measures were significantly more improved in all the three EPs 7630 groups compared to placebo (EQ-5D and EQ VAS, SF-12: physical score, impact of patient's sickness, duration of activity limitation, patient-reported treatment outcome, satisfaction with treatment). In conclusion, a statistically significant and clinically relevant improvement of HRQL/PRO compared to placebo was shown in all the three EPs 7630 groups.

  8. Successful cross-protective efficacy induced by heat-adapted live attenuated nephropathogenic infectious bronchitis virus derived from a natural recombinant strain.

    Science.gov (United States)

    Lim, Tae-Hyun; Youn, Ha-Na; Yuk, Seong-Su; Kwon, Jung-Hoon; Hong, Woo-Tack; Gwon, Gyeong-Bin; Lee, Jung-Ah; Lee, Joong-Bok; Lee, Sang-Won; Song, Chang-Seon

    2015-12-16

    A natural recombinant nephropathogenic K40/09 strain of infectious bronchitis virus (IBV) was heat-adapted for possible future use as live attenuated vaccine. The K40/09 strain was selected during successive serial passages in specific-pathogen free (SPF) embryonated eggs at sub-optimal higher temperature (56°C). Unlike the parental strain, the attenuated strain, designated K40/09 HP50, was found to be safe in 1-day-old SPF chicks, which showed neither mortality nor signs of morbidity, and rarely induced ciliostasis or histological changes in the trachea and kidney after intraocular and fine-spray administration. K40/09 HP50 provided almost complete protection against two distinct subgroups of a nephropathogenic strain (KM91-like and QX-like subgroup) and elicited the production of high titers of neutralizing antibody (neutralization index of 3.6). We conclude that the K40/09 HP50 vaccine virus is rapidly attenuated by heat adaptation and exhibits the desired level of attenuation, immunogenicity, and protective efficacy required for a live attenuated vaccine. These results indicate that the K40/09 vaccine could be helpful for the reduction of economic losses caused by recently emergent nephropathogenic IBV infection in many countries.

  9. Comparison between dot-immunoblotting assay and clinical sign determination method for quantifying avian infectious bronchitis virus vaccine by titration in embryonated eggs.

    Science.gov (United States)

    Yuk, Seong-su; Kwon, Jung-Hoon; Noh, Jin-Yong; Hong, Woo-tack; Gwon, Gyeong-Bin; Jeong, Jei-Hyun; Jeong, Sol; Youn, Ha-Na; Heo, Yong-Hwan; Lee, Joong-Bok; Park, Seung-Yong; Choi, In-Soo; Song, Chang-Seon

    2016-04-01

    A sensitive and specific method for measuring the vaccine titer of infectious bronchitis virus (IBV) is important to commercial manufacturers for improving vaccine quality. Typically, IBV is titrated in embryonated chicken eggs, and the infectivity of the virus dilutions is determined by assessing clinical signs in the embryos as evidence of viral propagation. In this study, we used a dot-immunoblotting assay (DIA) to measure the titers of IBV vaccines that originated from different pathogenic strains or attenuation methods in embryonated eggs, and we compared this assay to the currently used method, clinical sign evaluation. To compare the two methods, we used real-time reverse transcription-PCR, which had the lowest limit of detection for propagated IBV. As a clinical sign of infection, dwarfism of the embryo was quantified using the embryo: egg (EE) index. The DIA showed 9.41% higher sensitivity and 15.5% higher specificity than the clinical sign determination method. The DIA was particularly useful for measuring the titer of IBV vaccine that did not cause apparent stunting but propagated in embryonated chicken eggs such as a heat-adapted vaccine strain. The results of this study indicate that the DIA is a rapid, sensitive, reliable method for determining IBV vaccine titer in embryonated eggs at a relatively low cost.

  10. Eggshell apex abnormalities in a free-range hen farm with mycoplasma synoviae and infectious bronchitis virus in Rio de Janeiro state, Brazil

    Directory of Open Access Journals (Sweden)

    FC dos Santos

    2014-06-01

    Full Text Available A farm with 3,000 free-range hens between 24 and 65 weeks of age was investigated. These hens were separated in small flocks of 400 to 700 birds, presenting 10 to 23% egg production reduction. Twenty serum samples were collected during the period of drop in egg production and three weeks later for the investigation of Mycoplasma synoviae (MS, M. gallisepticum (MG and Infectious Bronchitis Virus (IBV antibodies using ELISA. At the time of the second collection, egg production had resumed to normal levels; however, with 10.23% of the eggs showed eggshell abnormalities limited to the apex. Eggshell strength was significantly different between normal and those with eggshell apex abnormalities, but not other egg-quality parameters. ELISA tests showed that MS and IBV titers increased during the evaluated period. MS infection was confirmed by culture and by PCR of tracheal swabs. All samples were negative for MG by ELISA and PCR. Further studies with larger samples to ensure the occurrence of this disease in industrial layer flocks in Brazil are under way.

  11. Evaluation of a novel strain of infectious bronchitis virus emerged as a result of spike gene recombination between two highly diverged parent strains.

    Science.gov (United States)

    Hewson, Kylie A; Noormohammadi, Amir H; Devlin, Joanne M; Browning, Glenn F; Schultz, Bridie K; Ignjatovic, Jagoda

    2014-01-01

    The emergence of new variant strains of the poultry pathogen infectious bronchitis virus (IBV) is continually reported worldwide, owing to the labile nature of the large single-stranded RNA IBV genome. High resolution melt curve analysis previously detected a variant strain, N1/08, and the present study confirmed that this strain had emerged as a result of recombination between Australian subgroup 2 and 3 strains in the spike gene region, in a similar manner reported for turkey coronaviruses. The S1 gene for N1/08 had highest nucleotide similarity with subgroup 2 strains, which is interesting considering subgroup 2 strains have not been detected since the early 1990s. SimPlot analysis of the 7.2-kb 3' end of the N1/08 genome with the same region for other Australian reference strains identified the sites of recombination as immediately upstream and downstream of the S1 gene. A pathogenicity study in 2-week-old chickens found that N1/08 had similar pathogenicity for chicken respiratory tissues to that reported for subgroup 2 strains rather than subgroup 3 strains. The results of this study demonstrate that recombination is a mechanism utilized for the emergence of new strains of IBV, with the ability to alter strain pathogenicity in a single generation.

  12. Rapid detection and non-subjective characterisation of infectious bronchitis virus isolates using high-resolution melt curve analysis and a mathematical model.

    Science.gov (United States)

    Hewson, Kylie; Noormohammadi, Amir H; Devlin, Joanne M; Mardani, Karim; Ignjatovic, Jagoda

    2009-01-01

    Infectious bronchitis virus (IBV) is a coronavirus that causes upper respiratory, renal and/or reproductive diseases with high morbidity in poultry. Classification of IBV is important for implementation of vaccination strategies to control the disease in commercial poultry. Currently, the lengthy process of sequence analysis of the IBV S1 gene is considered the gold standard for IBV strain identification, with a high nucleotide identity (e.g. > or =95%) indicating related strains. However, this gene has a high propensity to mutate and/or undergo recombination, and alone it may not be reliable for strain identification. A real-time polymerase chain reaction (RT-PCR) combined with high-resolution melt (HRM) curve analysis was developed based on the 3'UTR of IBV for rapid detection and classification of IBV from commercial poultry. HRM curves generated from 230 to 435-bp PCR products of several IBV strains were subjected to further analysis using a mathematical model also developed during this study. It was shown that a combination of HRM curve analysis and the mathematical model could reliably group 189 out of 190 comparisons of pairs of IBV strains in accordance with their 3'UTR and S1 gene identities. The newly developed RT-PCR/HRM curve analysis model could detect and rapidly identify novel and vaccine-related IBV strains, as confirmed by S1 gene and 3'UTR nucleotide sequences. This model is a rapid, reliable, accurate and non-subjective system for detection of IBVs in poultry flocks.

  13. Untying chronic pain

    OpenAIRE

    Häuser, Winfried; Wolfe, Frederik; Henningsen, Peter; Schmutzer, Gabriele; Brähler, Elmar; Hinz, Andreas

    2014-01-01

    Background: Chronic pain is a major public health problem. The impact of stages of chronic pain adjusted for disease load on societal burden has not been assessed in population surveys. Methods: A cross-sectional survey with 4360 people aged ≥ 14 years representative of the German population was conducted. Measures obtained included demographic variables, presence of chronic pain (based on the definition of the International Association for the Study of Pain), chronic pain stages (by chronic ...

  14. Chronic pain after hysterectomy

    DEFF Research Database (Denmark)

    Brandsborg, B.; Nikolajsen, L.; Kehlet, H.;

    2008-01-01

    BACKGROUND: Chronic pain is a well-known adverse effect of surgery, but the risk of chronic pain after gynaecological surgery is less established. METHOD: This review summarizes studies on chronic pain following hysterectomy. The underlying mechanisms and risk factors for the development of chronic...... post-hysterectomy pain are discussed. RESULTS AND CONCLUSION: Chronic pain is reported by 5-32% of women after hysterectomy. A guideline is proposed for future prospective studies Udgivelsesdato: 2008/3...

  15. Chronic pain after hysterectomy

    DEFF Research Database (Denmark)

    Brandsborg, B; Nikolajsen, L; Kehlet, Henrik;

    2008-01-01

    BACKGROUND: Chronic pain is a well-known adverse effect of surgery, but the risk of chronic pain after gynaecological surgery is less established. METHOD: This review summarizes studies on chronic pain following hysterectomy. The underlying mechanisms and risk factors for the development of chronic...... post-hysterectomy pain are discussed. RESULTS AND CONCLUSION: Chronic pain is reported by 5-32% of women after hysterectomy. A guideline is proposed for future prospective studies. Udgivelsesdato: 2008-Mar...

  16. Discrepancy between presumptive and definite causes of chronic cough

    Institute of Scientific and Technical Information of China (English)

    YU Li; QIU Zhi-hong; WEI Wei-li; LIU Bo; XU Xiang-huai; L(U) Han-jing; QIU Zhong-min

    2011-01-01

    Background The current diagnostic algorithms for chronic cough require the establishment of the primary presumptive causes followed by the confirmation of diagnosis with the specific therapies.The aim of the study was to investigate the discrepancy between presumptive and definite causes and its clinical implication.Methods A total of 109 patients with chronic cough underwent laboratory investigations to identify the cause of cough; including sinus computerized tomography (if needed),histamine bronchial provocation,induced sputum cytology and 24-hour esophageal pH or multi-channel intraluminal impedance combined with pH monitoring.The presumptive causes were confirmed by treating them sequentially.The difference between presumptive and definite causes of chronic cough was compared.Results Single cause was more frequent in the definite diagnosis than in the presumptive diagnosis (78.9% vs.54.1%,x2=15.01,P=0.0001).In contrast,multiple causes were significantly fewer in definite diagnosis than in the presumptive diagnosis (15.6% vs.37.6%,x2=13.53,P=0.0002).There was a discrepancy between definite and presumptive causes in 30 patients (27.5%).Compared with the presumptive causes,definite upper airway cough syndrome (24.8% vs.11.9%,x2=6.0,P=0.01) and gastroesophageal reflux disease (6.4% vs.0,x2=7.23,P=0.007) was more frequent as a single cause of chronic cough while cough variant asthma plus gastroesophageal reflux disease (3.7% vs.11.9%,x2=5.17,P=0.02) and upper airway cough syndrome plus nonasthmatic eosinophilic bronchitis (0 vs.9.2%,x2=10.48,P=0.001) were fewer as multiple causes of chronic cough.Conclusions A discrepancy was common between presumptive and definite causes of chronic cough.To treat presumptive causes sequentially may be a suitable solution for avoidance of erroneous multiple causes and possible over-treatment.

  17. A STUDY OF CLINICAL PROFILE, RADIOLOGICAL FEATURES, ELECTROCARDIOGRAPHIC AND ECHOCARDIOGRAPHIC CHANGES IN CHRONIC COR PULMONALE IN A RURAL HOSPITAL

    Directory of Open Access Journals (Sweden)

    Sunil Babu

    2013-11-01

    Full Text Available ABSTRACT: BACKGROUND AND OBJECTIVES: To study the clinical profile, radiological features, electrocardiographic and echocardiographic changes in clinically proven cases of chronic cor pulmonale. METHODS: 50 patients who were diagnosed to have chronic cor pulmonale based on the inclusion criteria were selected from the medical wards of Adichunchanagiri Hospital and research centre, over a period of 2 years In all the selected patients detailed history and physical examination was noted and chest x - ray PA, 1 2 lead ECG and echocardiogram done. RESULTS: Among 50 patients admitted with chronic cor pulmonale, 45 were males and 5 were females. The peak incidence was found in the 4 th , 5 th and 6 th decades of life. Smoking was found to be a major cause for COPD and h ence cor pulmonale. Among 50 patients 43 were smokers. Among 50 cases, (60% were diagnosed to have chronic bronchitis with or without emphysema. Chest x - ray showed details relevant to the clinical profile. ECG showed 46% cases with RVH, 64% with RAD, 26% RBBB and 70% with P pulmonale. Every patient showed echocardiographic features suggesting chronic cor pulmonale except 3 patients who showed global hypokinesia. DISCUSSION AND CONCLUSION: Many patients who had chronic cor pulmonale were found to have COPD as the underlying disease. Majority of the male patients were smokers in the present study. Echocardiogram was found to be a better diagnostic tool. Though ECG and chest x - ray can support the diagnosis, ECHO can be used as a non invasive, affordable invest igation for accurate and early diagnosis of chronic cor pulmonale KEYWORDS: Chronic cor pulmonale; Clinical profile; Chest x ray; ECG; Echocardiogram.

  18. 鸡传染性支气管炎病毒的分离与鉴定%solation and Identification of Avian Infectious Bronchitis Virus

    Institute of Scientific and Technical Information of China (English)

    王正东; 余弟和; 张建军; 魏波

    2012-01-01

    [Objective]The aim of the study was to isolate an avian infectious bronchitis virus(IBV) isolate from the diseased chickens and identity its characteristics. [Method] An 1BV isolate was isolated from the diseased chickens in a chicken farm in Anhui Province and passaged blindly in chicken embryos to observe its pathogenicity. Then animal regression test was used to replicate bronchial congestion in SPF chickens. The SI gene fragment was amplified and its sequence was aligned with the IBV vaccine strains. [ Result ] The results of HA assay showed that the allantoic fluid of the IBV strain had no agglutination activity toward chicken red blood cells. This result suggested that no Newcastle disease virus and avian influenza virus were found in the allantoic fluid. However,the allanloic fluid treated with 10 g/L trypsin solution could agglutinate chicken red blood cells, which is in line with the biological characteristics of IBV. After the SPF chickens were inoculated with the sixth passage of the IBV I-solate, the clinical symptoms like bronchial congestion that were similar with those in clinic were observed. The results initially confirmed the isolation of an IBV isolate,which was named IBV XZ strain. [Conclusion]This study provides a theoretical basis for the prevention and treatment of avian infectious bronchitis.%[目的]从发病鸡群中分离出鸡传染性支气管炎病毒,并对其进行鉴定.[方法]从安徽某鸡场发病鸡群中分离出鸡传染性支气管是病毒,采用鸡胚盲传,观察病毒对鸡胚的致病作用.通过动物回归试验,在SPF鸡上复制出支气管堵塞的症状,扩增分离毒株的S1基因片段,并与IBV疫苗毒株进行比较.[结果]对分离到的毒株进行HA检测,结果表明收获的尿囊液对鸡红细胞无凝集活性,说明分离到的病毒中无NDV、AIV等,但经1%胰酶处理则可凝集鸡红细胞,符合传染性支气管炎病毒的生物学特征.该毒株的第6代SPF鸡胚尿囊液通过滴

  19. Using Correction Equations Based on Measured Height and Weight Weakens Associations between Obesity Based on Self-Reports and Chronic Diseases

    Directory of Open Access Journals (Sweden)

    Cynthia L. Murray

    2013-01-01

    Full Text Available Objective. Researchers have established a preponderance of height overestimation among men and weight underestimation among women in self-reported anthropometric data, which skews obesity prevalence data and obscures obesity-chronic disease relationships. The objective of this study was to reevaluate associations between obesity and chronic diseases using body mass index (BMI correction equations derived from measured data. Methods. Measured height and weight (MHW data were collected on a subsample of the 17,126 Atlantic Canadians who participated in the 2007-2008 Canadian Community Health Survey (CCHS. To obtain corrected BMI estimates for the 17,126 adults, correction equations were developed in the MHW subsample and multiple regression procedures were used to model BMI. To test obesity-chronic disease relationships, logistic regression models were utilized. Results. The correction procedure eliminated statistically significant relations (P<0.05 between obesity and chronic bronchitis and obesity and stroke. Also, correction attenuated many relationships between adiposity and chronic disease. For example, among obese adults, there was a 13%, 12%, and 7% reduction in the adjusted odds ratios for asthma, urinary incontinence, and cardiovascular disease, respectively. Conclusion. Further research is needed to fully understand how the usage of self-reported data alters our understanding of the relationships between overweight or obesity and chronic diseases.

  20. [Sequencing and Serologic Identification of S1 Genes of Infectious Bronchitis Viruses Isolated during 2012-2013 in Guangxi Province, China].

    Science.gov (United States)

    Zhang, Lihua; Wu, Cuilan; Zhang, Zhipeng; He, Yining; Li, Heming; Qin, Lili; Wei, Tianchao; Mo, Meilan; Wei, Ping

    2016-01-01

    We wished to ascertain the prevalence as well as the genetic and antigenic variation of infectious bronchitis viruses (IBVs) circulating in the Guangxi Province of China in recent years. The S1 gene of 15 IBV field isolates during 2012-2013 underwent analyses in terms of the similarity of amino-acid sequences, creation of phylogenetic trees, recombination, and serologic identification. Similarities in amino-acid sequences among the 15 isolates of the S1 gene were 54.3%-99.6%, and 43.3%-99.3% among 15 isolates and reference strains. Compared with the vaccine strain H120, except for GX-YL130025, the other 14 isolates showed a lower similarity of amino-acid sequences of the S1 gene (65.1-81.4%). Phylogenetic analyses of the S1 gene suggested that 15 IBV isolates were classified into eight genotypes, with the predominant genotype being new-type II. Recombination analyses demonstrated that the S1 gene of the GX-NN130048 isolate originated from recombination events between vaccine strain 4/91 and a LX4-like isolate. Serotyping results suggested that seven serotypes prevailed during 2012-2013 in Guangxi Province, and that only one isolate was consistent with the vaccine strain H120 in serotype (which has been used widely in recent years). The serotype of recombinant isolate GX-NN130048 was different from those of its parent strains. These results suggested that not only the genotype, but also the serotype of IBV field isolates in Guangxi Province had distinct variations, and that increasing numbers of genotypes and serotypes are in circulation. We showed that recombination events can lead to the emergence of new serotypes. Our study provides new evidence for understanding of the molecular mechanisms of IBV variations, and the development of new vaccines against IBVs. PMID:27295885

  1. S1 gene sequence analysis of infectious bronchitis virus vaccinal strains (H120 & H52 and their embryo-passaged derivatives

    Directory of Open Access Journals (Sweden)

    Bakhshesh, M.

    2016-07-01

    Full Text Available Avian infectious bronchitis is an acute and highly contagious disease that mainly causes respiratory symptoms in poultry. A number of serotypes and variants of the viral agent with poor cross-protection are the major problem to achieve desired immunity from vaccination. The S1 subunit of S glycoprotein (spike is the major determinant of IBV so that a minor change in amino acid sequence of this protein, alters the virus strain. Therefore, characterization of the sequence of S1 gene is necessary to identify virus strains and their similarities with the vaccinal strains. In this research, the S1 sequence of H52 and H120 vaccinal strains of Razi Institute was fully characterized, and also the effect of serial passages in embryonated - eggs (5 passages beyond the master seed on the S1 gene was investigated. The results showed that H120 and H52 strains of Razi Institute are 100% identical to the reference vaccine strains available in the GenBank. In addition, the H52 strain showed one amino acid substitution from the 3rd passage in which Glycine (G was replaced by Valine (V at position 118 making these passages exactly identical to the H120 strain while no change occurred for the H120 strain during these passages. Analysis of the original vaccinal strains which are widely administered in Iran, is definitely useful for prevention and control strategies against the circulating viruses. To identify the genetic change(s responsible for attenuation of these strains during passages in embryonated-egg, characterization of other genes, especially those involved in replication is recommended.

  2. Chronic mucus hypersecretion

    DEFF Research Database (Denmark)

    Ulrik, Charlotte Suppli; von Linstow, Marie-Louise; Nepper-Christensen, Steen;

    2005-01-01

    To investigate if chronic mucus hypersecretion (CMH) can be used as a marker of asthma in young adults.......To investigate if chronic mucus hypersecretion (CMH) can be used as a marker of asthma in young adults....

  3. Chronic Diarrhea in Children

    Science.gov (United States)

    ... can include cramping abdominal pain nausea or vomiting fever chills bloody stools Children with chronic diarrhea who have ... can include cramping, abdominal pain, nausea or vomiting, fever, chills, or bloody stools. Children with chronic diarrhea who ...

  4. Chronic inflammatory demyelinating polyneuropathy

    Science.gov (United States)

    Polyneuropathy - chronic inflammatory; CIDP; Chronic inflammatory polyneuropathy; Guillain-Barré - CIDP ... CIDP is one cause of damage to nerves outside the brain or spinal cord ( peripheral neuropathy ). Polyneuropathy ...

  5. Chronic fatigue syndrome

    Science.gov (United States)

    Bennett RM. Fibromyalgia, chronic fatigue syndrome, and myofascial pain. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine . 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 274. Engleberg NC. Chronic ...

  6. "Chronic Lyme Disease"

    Science.gov (United States)

    ... Content Marketing Share this: Main Content Area "Chronic Lyme Disease" What is "chronic Lyme disease?" Lyme disease is an infection caused by ... J Med 357:1422-30, 2008). How is Lyme disease treated? For early Lyme disease, a short ...

  7. 24-HOUR ARTERIAL STIFFNESS VALUES IN MEN WITH DIFFERENT PHENOTYPES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE CONCURRENT WITH HYPERTENSION

    Directory of Open Access Journals (Sweden)

    N. A. Karoli

    2015-01-01

    Full Text Available Objective: to study the specific features of the daily arterial stiffness (AS profile in men with different phenotypes of chronic obstructive pulmonary disease (COPD concurrent with hypertension. Subjects and methods. The investigation enrolled 78 male patients with COPD and hypertension. The patients were divided according to COPD phenotypes into 2 groups: 1 COPD patients with emphysema; 2 those with bronchitis. The exclusion criteria were less than 40 years and more than 80 years of age; diabetes mellitus; coronary heart disease; vascular diseases; an exacerbation of chronic diseases; bronchial and pulmonary diseases of another etiology. The patients underwent 24-hour blood pressure and AS monitoring, external respiratory function testing: spirography with a short-acting β2-agonist test, a six-minute walk test at baseline and after a hemoglobin oxygen saturation test, and a CAT test. Results. The patients of both groups were observed to have a statistically significant increase in (dP/dtmax as compared to those of the control group (p < 0.05; p < 0.01 in both the daytime and nighttime. In these periods, the COPD patients with emphysema had a higher AIx than those with bronchitis (p < 0.001. There was a statistically significantly (p < 0.001 higher AIx in the nighttime than in the daytime in Groups 1 and 2 patients. Conclusion. The patients with different COPD phenotypes were noted to have impaired arterial elastic properties, circadian AS changes with predominantly nocturnal impaired vascular stiffness. Relationships were found between 24-hour AS values and clinicoanamnestic findings. 

  8. Prostaglandins and chronic inflammation

    OpenAIRE

    Aoki, Tomohiro; Narumiya, Shuh

    2012-01-01

    Chronic inflammation is the basis of various chronic illnesses including cancer and vascular diseases. However, much has yet to be learned how inflammation becomes chronic. Prostaglandins (PGs) are well established as mediators of acute inflammation, and recent studies in experimental animals have provided evidence that they also function in transition to and maintenance of chronic inflammation. One role PGs play in such processes is amplification of cytokine signaling. As such, PGs can facil...

  9. Chronic Inflammatory Demyelinating Polyneuropathy

    OpenAIRE

    Dimachkie, Mazen M.; Barohn, Richard J.

    2013-01-01

    Chronic Inflammatory polyneuropathies are an important group of neuromuscular disorders that present chronically and progress over more than 8 weeks, being referred to as chronic inflammatory demyelinating polyneuropathy (CIDP). Despite tremendous progress in elucidating disease pathogenesis, the exact triggering event remains unknown. Our knowledge regarding diagnosis and management of CIDP and its variants continues to expand, resulting in improved opportunities for identification and treat...

  10. The Yanhuning injection in the treatment of acute bronchitis effect observed%炎琥宁注射液治疗急性支气管炎的效果观察

    Institute of Scientific and Technical Information of China (English)

    李瑛

    2012-01-01

      Objective Used in acute bronchitis Yanhuning injection effect for study. Methods Random selection in our hospital from June 2010 to June 2012 79 patients with acute bronchitis, divided into A and B group, A group of 45 patients for the treatment group, B group 34 patients of the control group were given Yanhuning injectionfluids and amoxicilin healing.Results A group of patients after treatment, fever, and other symptoms of wheezing and wheezing disappeared improve less than group B patients, treatment efficiency than in group B, the incidence of adverse reactions was significantly lower than that in group B patients.Conclusion Yanhuning injection used in acute bronchitis, a faster recovery of the patient's condition, there are more efficient.%  目的对炎琥宁注射液应用于急性支气管炎的效果加以研究分析。方法随机选择我院2010年6月-2012年6月急性支气管炎患者79名,分成A、B组,A组45名患者为治疗组,B组34名患者为对照组,分别给予炎琥宁注射液和阿莫西林医治。结果经治疗,A组患者发热、喘憋以及喘鸣音消失等病症改善时间均少于B组患者,治疗有效率高于B组,不良反应发生率明显低于B组患者。结论炎琥宁注射液应用于急性支气管炎,患者病症恢复较快,有效率较高。

  11. Contribution of pulmonary emphysema to functional impairment in patients with severe chronic obstructive pulmonary disease. A high-resolution CT study

    International Nuclear Information System (INIS)

    The purpose of the paper is to investigate whether high-resolution CT (HRCT) can detect the subjects with massive emphysematous destruction in a group of patients with severe chronic obstructive pulmonary disease (COPD) and therefor be of help in selecting the candidates to surgical lung volume reduction. Have been examined 40 former smokers with severe COPD (FEV1≤40% of the predicted value, with no major improvement after inhalation of bronchodilators). The emphysema extent score was significantly correlated with the hematocrit value and Tiffeneau index (p1 was significantly correlated with emphysema extent (p<1) in dyspnoeic, but not in bronchitis, patients. Moreover, the former had better arterial blood gas and lower hematocrit values. HRCT is a useful tool in diagnosing the presence of emphysema in vivo and in assessing its extent in COPD patients because it permits to divide the patients in two groups which roughly correspond to the clinical patterns of types A (dyspnoeic) and B (bronchitis). Severe emphysema patients are the best candidates to surgical lung volume reduction. Airways involvement might play a major role in causing bronchial obstruction in the subjects with mild emphysema. In these series HRCT did assess the severity of emphysema in COPD subjects, but the lung function screening failed to predict emphysema extent

  12. 加减桑菊饮治疗支气管炎24例疗效观察%Clinical observation on treating 24 cases of bronchitis by the Sangju decoction

    Institute of Scientific and Technical Information of China (English)

    佘佑林

    2013-01-01

      目的:探讨中药组方桑菊饮的加减治疗支气管炎的临床疗效,以期为临床用药提供数据支持。方法:将我院于2011年6月~2012年6月间收治的48例支气管炎患者随机分为两组,每组24例患者,实验组根据中医辨证论治的原则给予加减桑菊饮治疗;对照组则采用急支糖浆进行治疗,治疗7d后对比两组疗效。结果:经治疗后,实验组患者总有效率为83.3%;对照组为66.7%,实验组疗效显著优于对照组(x2=4.763,P<0.05)。结论:根据中医辨证论治的原则采用加减桑菊饮治疗支气管炎疗效显著,值得进行临床推广。%Objective:To investigate the clinical efficacy of TCD Sangju decoction in treating bronchitis, to provide data support for the clinical use of drugs. Methods:48 cases of bronchitis patients admitted to our hospital from June 2011 to June 2012 were randomly divided into two groups, 24 cases in each group. Experimental group was given addition and subtraction of Sangju decoction according to the principles of TCM;the control group received the treatment of acute bronchitis syrup, after 7 days treatment, comparing the clinical effect of the two groups. Results: The total efficiency of the treatment group was 83.3%, and 66.7% in the control group. There was a significant difference (P<0.05) in two groups. Conclusion:The treatment of bronchitis with addition and subtraction of SangJu decoction which is according to the principles of TCM obtained a significant clinical effects.

  13. Chronic granulomatous disease associated with chronic glomerulonephritis

    DEFF Research Database (Denmark)

    Frifelt, J J; Schønheyder, Henrik Carl; Valerius, Niels Henrik;

    1985-01-01

    A boy with chronic granulomatous disease (CGD) developed glomerulonephritis at the age of 12 years. The glomerulonephritis progressed to terminal uraemia at age 15 when maintenance haemodialysis was started. The clinical course was complicated by pulmonary aspergillosis and Pseudomonas septicaemia...

  14. Using oxygen at home

    Science.gov (United States)

    Oxygen - home use; COPD - home oxygen; Chronic obstructive airways disease - home oxygen; Chronic obstructive lung disease - home oxygen; Chronic bronchitis - home oxygen; Emphysema - home oxygen; Chronic respiratory ...

  15. Levocloperastine in the treatment of chronic nonproductive cough: comparative efficacy versus standard antitussive agents.

    Science.gov (United States)

    Aliprandi, P; Castelli, C; Bernorio, S; Dell'Abate, E; Carrara, M

    2004-01-01

    The medical and social impact of cough is substantial. Current antitussive agents at effective doses have adverse events such as drowsiness, nausea and constipation that limit their use. There is also recent evidence that standard antitussive agents, such as codeine, may not reduce cough during upper respiratory infections. Therefore, there is a need for more effective and better-tolerated agents. The efficacy of levocloperastine, a novel antitussive, which acts both centrally on the cough center and on peripheral receptors in the tracheobronchial tree in treating chronic cough, was compared with that of other standard antitussive agents (codeine, levodropropizine and DL-cloperastine) in six open clinical trials. The studies enrolled patients of all ages with cough associated with various respiratory disorders including bronchitis, asthma, pneumonia and chronic obstructive pulmonary disease. Levocloperastine significantly improved cough symptoms (intensity and frequency of cough) in all trials, and improvements were observed after the first day of treatment. In children, levocloperastine reduced nighttime awakenings and irritability, and in adults it was effective in treating cough induced by angiotensin-converting enzyme inhibitors. When compared with other antitussive agents, levocloperastine had improved or comparable efficacy, with a more rapid onset of action. Importantly, no evidence of central adverse events was recorded with levocloperastine, whereas drowsiness was reported by a significant number of patients receiving codeine. Levocloperastine is an effective antitussive agent for the treatment of cough in patients of all ages. It has a more rapid onset of action than standard agents with an improved tolerability profile.

  16. THE EFFECTS OF PRACTICING SWIMMING IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE. CASE STUDY

    Directory of Open Access Journals (Sweden)

    Petrescu S.

    2015-08-01

    Full Text Available Chronic obstructive pulmonary disease (COPD is comprised primarily of two related diseases - chronic bronchitis and emphysema. Clinical research on the effects of swimming on the quality of the life of patients with various lung diseases showed that the use of water therapy programs have significant effects on the induction of pulmonary edema as well as on mild to moderate asthma. The case study presented in this study, aged 52, male, from urban area, smoker (30PA, with a weight of 96 kg and a height of 168 cm, was diagnosed with COPD in GOLD III std about 2 years ago and abdominal obesity. The functional examinations have revealed a mixed ventilatory dysfunction with FEV of 48.6% and 68.3% CV. The therapy with tiotropium and beta 2 agonists initiated as needed, along with physical therapy. After the application of aquatic programs for 6 months the results have highlighted significant changes in the lung functionality and the quality of everyday life.

  17. Correlation between high-resolution computed tomography features and patients′ characteristics in chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Gupta Prem

    2008-01-01

    Full Text Available Background: During the last few decades, high-resolution computed tomography (HRCT has come up as a new diagnostic modality to diagnose emphysematous and chronic bronchitis components of chronic obstructive pulmonary disease (COPD. The present study was undertaken to evaluate for various quantitative and qualitative HRCT features in patients with COPD, and to detect patients′ characteristics that correlate with these HRCT features. Materials and Methods: Forty male patients with COPD attending the COPD clinic at a tertiary referral hospital and postgraduate medical institute were included in the study. Various HRCT features, including tracheal index, thoracic cage ratio, sterno-aortic distance, thoracic cross-sectional area, vascular attenuation, vascular distortion, mosaic attenuation pattern, and directly visible small airways, were evaluated and correlated with patients′ characteristics, including age, duration of illness, quantum of smoking, dyspnea score, quality-of-life index, and various spirometric indices. Results: We found significant correlations of various quantitative and qualitative HRCT features with age, duration of illness, quantum of smoking, quality-of-life index, and the spirometric indices showing the extent of airways obstruction. Conclusions: Various quantitative and qualitative HRCT features were found to correlate with patients′ characteristics, spirometric indices, and health-related quality-of-life score, suggesting that HRCT is useful not only in detecting emphysema and its various subtypes but also in predicting the extent and severity of COPD

  18. Chronic health effects of sulphur mustard exposure with special reference to Iranian veterans

    Directory of Open Access Journals (Sweden)

    B Balali-Mood

    2008-01-01

    Full Text Available The widespread use of sulphur mustard (SM as an incapacitating chemical warfare agent in the past century has proved its long-lasting toxic effects. It may also be used as a chemical terrorist agent. Therefore, all health professionals should have sufficient knowledge and be prepared for any such chemical attack. SM exerts direct toxic effects on the eyes, skin, and respiratory tissue, with subsequent systemic action on the nervous, immunological, haematological, digestive, and reproductive systems. SM is an alkylating agent that affects DNA synthesis, and, thus, delayed complications have been seen since the First World War. Cases of malignancies in the target organs, particularly in haematopoietic, respiratory, and digestive systems, have been reported. Important delayed respiratory complications include chronic bronchitis, bronchiectasis, frequent bronchopneumonia, and pulmonary fibrosis, all of which tend to deteriorate with time. Severe dry skin, delayed keratitis, and reduction of natural killer cells with subsequent increased risk of infections and malignancies are also among the most distressing long-term consequences of SM intoxication. However, despite a lot of research over the past decades on Iranian veterans, there are still major gaps in the SM literature. Immunological and neurological dysfunction, as well as the relationship between SM exposure and mutagenicity, carcinogenicity, and teratogenicity are important fields that require further studies, particularly on Iranian veterans with chronic health effects of SM poisoning. There is also a paucity of information on the medical management of acute and delayed toxic effects of SM poisoning—a subject that greatly challenges health care specialists.

  19. Levocloperastine in the treatment of chronic nonproductive cough: comparative efficacy versus standard antitussive agents.

    Science.gov (United States)

    Aliprandi, P; Castelli, C; Bernorio, S; Dell'Abate, E; Carrara, M

    2004-01-01

    The medical and social impact of cough is substantial. Current antitussive agents at effective doses have adverse events such as drowsiness, nausea and constipation that limit their use. There is also recent evidence that standard antitussive agents, such as codeine, may not reduce cough during upper respiratory infections. Therefore, there is a need for more effective and better-tolerated agents. The efficacy of levocloperastine, a novel antitussive, which acts both centrally on the cough center and on peripheral receptors in the tracheobronchial tree in treating chronic cough, was compared with that of other standard antitussive agents (codeine, levodropropizine and DL-cloperastine) in six open clinical trials. The studies enrolled patients of all ages with cough associated with various respiratory disorders including bronchitis, asthma, pneumonia and chronic obstructive pulmonary disease. Levocloperastine significantly improved cough symptoms (intensity and frequency of cough) in all trials, and improvements were observed after the first day of treatment. In children, levocloperastine reduced nighttime awakenings and irritability, and in adults it was effective in treating cough induced by angiotensin-converting enzyme inhibitors. When compared with other antitussive agents, levocloperastine had improved or comparable efficacy, with a more rapid onset of action. Importantly, no evidence of central adverse events was recorded with levocloperastine, whereas drowsiness was reported by a significant number of patients receiving codeine. Levocloperastine is an effective antitussive agent for the treatment of cough in patients of all ages. It has a more rapid onset of action than standard agents with an improved tolerability profile. PMID:15553659

  20. Chronic respiratory diseases and quality of life in elderly nursing home residents.

    Science.gov (United States)

    Carreiro-Martins, Pedro; Gomes-Belo, Joana; Papoila, Ana Luísa; Caires, Iolanda; Palmeiro, Teresa; Gaspar-Marques, João; Leiria-Pinto, Paula; Mendes, Ana Sofia; Paulo-Teixeira, João; Botelho, Maria Amália; Neuparth, Nuno

    2016-08-01

    Few studies have assessed the quality of life (QOL) related to chronic respiratory diseases in the elderly. In the framework of the geriatric study on the health effects of air quality in elderly care centers (GERIA) study, a questionnaire was completed by elderly subjects from 53 selected nursing homes. It included various sections in order to assess respiratory complaints, QOL (World Health Organization QOL (WHOQOL)-BREF), and the cognitive and depression status. The outcome variables were the presence of a score lower than 50 (current wheezing, asthma, and allergic rhinitis were considered as potential risk factors. The surveyed sample was (n = 887) 79% female, with a mean age of 84 years (SD: 7 years). In the multivariable analysis, a score of <50 in the physical domain was associated with wheezing in the previous 12 months (odds ratio (OR): 2.03, confidence interval (CI): 1.25-3.31) and asthma (OR: 1.95, CI: 1.12-3.38). The psychological domain was related with a frequent cough (OR: 1.43, CI: 0.95-2.91). A score of <50 in the environmental domain was associated with chronic bronchitis (OR: 2.89, CI: 1.34-6.23) and emphysema (OR: 3.89, CI: 1.27-11.88). In view of these findings, the presence of respiratory diseases seems to be an important risk factor for a low QOL among elderly nursing home residents. PMID:26965222

  1. Chronic penile strangulation

    OpenAIRE

    Lopes, Roberto I.; Silvia I Lopes; Roberto N. Lopes

    2003-01-01

    Chronic penile strangulation is exceedingly rare with only 5 cases previously reported. We report an additional case of progressive penile lymphedema due to chronic intermittent strangulation caused by a rubber band applied to the penile base for 6 years. A 49-year-old man presented incapacity to exteriorize the glans penis. For erotic purposes, he had been using a rubber-enlarging band placed in the penile base for 6 years. With chronic use, he noticed that his penis swelled. Physical examin...

  2. Influence of sex on chronic obstructive pulmonary disease risk and treatment outcomes

    Directory of Open Access Journals (Sweden)

    Aryal S

    2014-10-01

    Full Text Available Shambhu Aryal,1 Enrique Diaz-Guzman,2 David M Mannino3 1Division of Pulmonary, Allergy and Critical Care Medicine, Duke University, Durham, NC, 2Division of Pulmonary, Allergy and Critical Care, University of Alabama, Birmingham, AL, 3Department of Preventive Medicine and Environmental Health, University of Kentucky, Lexington, KY, USA Abstract: Chronic obstructive pulmonary disease (COPD, one of the most common chronic diseases and a leading cause of death, has historically been considered a disease of men. However, there has been a rapid increase in the prevalence, morbidity, and mortality of COPD in women over the last two decades. This has largely been attributed to historical increases in tobacco consumption among women. But the influence of sex on COPD is complex and involves several other factors, including differential susceptibility to the effects of tobacco, anatomic, hormonal, and behavioral differences, and differential response to therapy. Interestingly, nonsmokers with COPD are more likely to be women. In addition, women with COPD are more likely to have a chronic bronchitis phenotype, suffer from less cardiovascular comorbidity, have more concomitant depression and osteoporosis, and have a better outcome with acute exacerbations. Women historically have had lower mortality with COPD, but this is changing as well. There are also differences in how men and women respond to different therapies. Despite the changing face of COPD, care providers continue to harbor a sex bias, leading to underdiagnosis and delayed diagnosis of COPD in women. In this review, we present the current knowledge on the influence of sex on COPD risk factors, epidemiology, diagnosis, comorbidities, treatment, and outcomes, and how this knowledge may be applied to improve clinical practices and advance research. Keywords: chronic obstructive lung disease, sex, smoking, comorbidity, sex bias

  3. Using Health Utility Index (HUI for Measuring the Impact on Health-Related Quality of Life (HRQL Among Individuals with Chronic Diseases

    Directory of Open Access Journals (Sweden)

    Frank Mo

    2004-01-01

    Full Text Available Quality of life is an important indicator in assessing the burden of disease, especially for chronic conditions. The Health Utilities Index (HUI is a recently developed system for measuring the overall health status and health-related quality of life (HRQL of individuals, clinical groups, and general populations. Using the HUI (constructed based on eight attributes: vision, hearing, speech, mobility, dexterity, cognition, emotion, and pain/discomfort to measure the HRQL for chronic disease patients and to detect possible associations between HUI system and various chronic conditions, this study provides information to improve the management of chronic diseases.This study is of interest to data analysts, policy makers, and public health practitioners involved in descriptive clinical studies, clinical trials, program evaluation, population health planning, and assessments. Based on the Canadian Community Health Survey (CCHS for 2000–01, the HUI was used to measure the quality of life for individuals living with various chronic conditions (Alzheimer/other dementia, effects of stroke, urinary incontinence, arthritis/rheumatism, bowel disorder, cataracts, back problems, stomach/intestinal ulcers, emphysema/COPD, chronic bronchitis, epilepsy, heart disease, diabetes, migraine headaches, glaucoma, asthma, fibromyalgia, cancers, high blood pressure, multiple sclerosis, thyroid condition, and other remaining chronic diseases. Logistic Regression Model was employed to estimate the associations between the overall HUI scores and various chronic conditions. The HUI scores ranged from 0.00 (corresponding to a state close to death to 1.00 (corresponding to perfect health; negative scores reflect health states considered worse than death. The mean HUI score by sex and age group indicated the typical quality of life for persons with various chronic conditions. Logistic Regression results showed a strong relationship between low HUI scores (≤ 0.5 and 0.06

  4. Chronic diseases in adolescence

    Directory of Open Access Journals (Sweden)

    Rončević Nevenka

    2006-01-01

    Full Text Available Introduction. The prevalence of chronic diseases in adolescence is constantly increasing, especially in the last two decades. Adolescence is a period of important changes: body growth and development, sexual development, development of cognitive abilities, change in family relations and between peers, formation of personal identity and personal system of values, making decisions on future occupation etc. Chronic diseases in adolescence. Chronic disorders affect all development issues and represent an additional burden for adolescents. The interaction between chronic disorders and various development issues is complex and two-way: the disease may affect development, and development may affect the disease. Developmental, psychosocial and family factors are of great importance in the treatment of adolescents with chronic disorders. Chronic disorders affect all aspects of adolescent life, including relations with peers, school, nutrition, learning, traveling, entertainment, choice of occupation, plans for the future. Physicians should keep in mind that chronic diseases and their treatment represent only one aspect of person's life. Adolescents with chronic diseases have other needs as well, personal priorities, social roles and they expect these needs to be recognized and respected. Adolescent health care should be adjusted to the life style of adolescents.

  5. Managing your chronic pain

    Science.gov (United States)

    ... your chronic back pain To use the sharing features on this page, please enable JavaScript. Managing chronic pain means finding ways to make your back pain tolerable so you can live your life. You may not be able to ...

  6. Chronic gastritis - an update.

    Science.gov (United States)

    Varbanova, Mariya; Frauenschläger, Katrin; Malfertheiner, Peter

    2014-12-01

    Helicobacter pylori is the main aetiologic factor for chronic gastritis worldwide. The degree of inflammation and the evolution of this form of chronic gastritis can vary largely depending on bacterial virulence factors, host susceptibility factors and environmental conditions. Autoimmune gastritis is another cause of chronic inflammation in the stomach, which can occur in all age groups. This disease presents typically with vitamin B12 deficiency and pernicious anaemia. The presence of anti-parietal cell antibodies is highly specific for the diagnosis. The role of H. pylori as a trigger for autoimmune gastritis remains uncertain. Other rare conditions for chronic gastritis are chronic inflammatory conditions such as Crohn's disease or on the background of lymphocytic or collagenous gastroenteropathies. PMID:25439069

  7. [Chronic migraine: treatment].

    Science.gov (United States)

    Pascual, Julio

    2012-04-10

    We define chronic migraine as that clinical situation in which migraine attacks appear 15 or more days per month. Until recently, and in spite of its negative impact, patients with chronic migraine were excluded of the clinical trials. This manuscript revises the current treatment of chronic migraine. The first step should include the avoidance of potential precipitating/aggravating factors for chronic migraine, mainly analgesic overuse and the treatment of comorbid disorders, such as anxiety and depression. The symptomatic treatment should be based on the use of nonsteroidal anti-inflammatory agents and triptans (in this case ergotamine-containing medications. Preventive treatment includes a 'transitional' treatment with nonsteroidal anti-inflammatory agents or steroids, while preventive treatment exerts its actions. Even though those medications efficacious in episodic migraine prevention are used, the only drugs with demonstrated efficacy in the preventive treatment of chronic migraine are topiramate and pericranial infiltrations of Onabotulinumtoxin A. PMID:22532241

  8. Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

    Science.gov (United States)

    ... People About NINDS NINDS Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Information Page Table of Contents (click to jump ... en Español What is Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)? Chronic inflammatory demyelinating polyneuropathy (CIDP) is a neurological ...

  9. Stages of Chronic Myelogenous Leukemia

    Science.gov (United States)

    ... ALL Treatment Childhood AML Treatment Research Chronic Myelogenous Leukemia Treatment (PDQ®)–Patient Version General Information About Chronic Myelogenous Leukemia Go to Health Professional Version Key Points Chronic ...

  10. Stages of Chronic Lymphocytic Leukemia

    Science.gov (United States)

    ... ALL Treatment Childhood AML Treatment Research Chronic Lymphocytic Leukemia Treatment (PDQ®)–Patient Version General Information About Chronic Lymphocytic Leukemia Go to Health Professional Version Key Points Chronic ...

  11. 氨溴特罗治疗儿童急性支气管炎临床观察%Therapeutic Effect of Ambroxol and Clenbuterol Oral Solutions on Acute Bronchitis in Children

    Institute of Scientific and Technical Information of China (English)

    吴启富

    2012-01-01

    目的:探讨氨溴特罗口服液治疗儿童急性支气管炎的效果.方法:300例急性支气管炎患儿随机分成两组各150例.两组均在控制感染的基础上,治疗组口服氨溴特罗,对照组口服复方福尔可定,疗程5 d.观察两组临床疗效、不良反应和依从性.结果:治疗5 d后,治疗组总有效率(93.33%)明显高于对照组(84.67%),差异有统计学意义(P<0.05);咳嗽、痰量、痰黏稠度、喘息评分、不良反应发生率和依从性等方面比较,差异均有统计学意义(P<0.01或0.05).结论:氨溴特罗治疗急性支气管炎疗效显著,安全可靠,依从性好.%Objective: To evaluate the therapeutic effects of ambroxol and clenbuterol oral solutions on acute bronchitis in children. Method: Totally 300 cases with acute bronchitis were randomly divided into the treatment group ( 150 cases ) and the control group ( 150 cases). On the basis of anti-inflammatory therapy, ambroxol and clenbuterol oral solutions were given in the treatment group and pholcodine syrups were used in the control group for 5 days. The therapeutic effects, adverse reactions and compliance of the two groups were assessed. Result: After the treatment,the total effective rate of the treatment group( 93. 33% )was higher than that of the control group ( 84. 67% )( P<0. 05 ). The effects on cough,sputum volume,sputum viscosity and wheezing were much better in the treatment group than those in the control group( P<0. 01 ). There were significant statistic differences in the adverse reactions and compliance between the two groups( P<0. 05 ). Conclusion: Ambroxol and clenbuterol oral solutions are safe, convenient and highly effective in the treatment of acute bronchitis in children.

  12. 过敏原检测对小儿毛细支气管炎的临床意义探讨%clinical significance discussion of allergen detection to infantile capillary bronchitis

    Institute of Scientific and Technical Information of China (English)

    彭俊云; 吴赞开; 陆国伟; 李裕昌

    2013-01-01

    目的:探讨研究过敏原检测,对于小儿毛细支气管炎的临床意义。方法:选取我院儿科确诊的21例毛细支气管炎患儿作为观察组,同期住院的其他患儿21例作为对照组,均进行血清特异性IgE检测。通过两组患儿的血清特异性IgE水平以及随访3个月后的喘息发生率比较两组检测结果的意义。结果:观察组患儿血清特异性IgE水平显著高于对照组(P<0.05),随访3个月后观察组患儿喘息发生率高于对照组,差异有显著性(P<0.05)。结论:对毛细支气管炎患儿进行过敏原检测,可有效预测病情的严重程度和转归,有利于避开相关的触发因素,预防反复喘息发作甚至哮喘发生。%Objective:to explore the allergen detection, for the clinical significance of children capillary bronchitis. Selection. Methods:our hospital pediatric diagnosis of 21 cases of capillary bronchitis patients as observation group, other children in 21 cases as control group, both detection of serum specific IgE. Through two groups of children with serum specific IgE levels and followed up for 3 months after the incidence of breathing is the meaning of two groups of test results.Results:the observation group had a significantly higher serum specific IgE levels in children with the control group (P<0.05), the observation group were followed up for 3 months after children breathing rate is higher than the control group, with significant difference (P<0.05). Conclusions:children with capillary bronchitis is used to detect the allergen, which can effectively predict the severity of the illness, and outcome, to avoid trigger factors and prevention of recurrent wheeze and asthma.

  13. Therapeutic Effect of Budesonide Inhalation on Acute Infectious Laryngitis and Bronchitis%布地奈德吸入治疗急性喉炎、喉气管支气管炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    韩明达

    2015-01-01

    目的:分析探讨布地奈德吸入治疗急性喉炎、喉气管支气管炎症的临床效果。方法选取88例患有急性喉炎、喉气管支气管炎的患者作为研究对象,将其随机分成对照组和观察组,每组44例患者。对照组患者采用地塞米松静脉注射进行治疗,观察者则采取布地奈德雾化吸入进行治疗;治疗结束后,对比两组患者的治疗效果。结果采取布地奈德雾化吸入治疗的观察组患者在治疗效果及症状缓解上明显优于对照组,P<0.05,差异具有统计学意义。结论采用布地奈德雾化吸入治疗急性喉炎、喉气管支气管炎具有显著的治疗效果,患者症状能够得到迅速恢复。%Objective To explore the clinical effect analysis of budesonide inhalation in the treatment of acute laryngitis, bronchitis disease. Methods 88 cases with acute laryngitis, bronchitis of children as the research object, and were randomly separated into the observation group and the control group, 44 cases in each group of patients. The control group was treated with intravenous dexamethasone treatment, observers take budesonide inhalation treatment,in the end of the treatment, compared two groups of patients with treatment effect.Results Take budesonide atomization inhalation treatment observation group patients in the treatment and remission of symptoms signiifcantly better than the control group,P<0.05,with significant difference.Conclusion Inhalation in the treatment of acute laryngitis, bronchitis has signiifcant therapeutic effect of budesonide in children with symptoms, can be quickly restored.

  14. 关于毛细支气管炎雾化吸入疗法的应用价值评价%About the Application of Capillary Bronchitis Atomization Inhalation Therapy Value Evaluation

    Institute of Scientific and Technical Information of China (English)

    高莉莉; 何朝晖

    2015-01-01

    Objective To study the method of atomizing inhalation in patients with infantile capil ary bronchitis application value. Methods Choose 102 cases of children with capil ary bronchitis, grouping according to the fol owing conditions:the parents refused to don't cooperate with atomization inhalation atomization inhalation or babies, conventional intravenous anti-infection, cough, phlegm, and symptomatic, a total of 34 cases, as control group. Team is divided into: group A for pure atomization inhalation, A total of 32 cases; Group B for symptomatic treatment with oral drug aerosol inhalation, a total of 36 cases. The general clinical information col ection. Results In the treatment of 3 days, evaluate the ef ect of three groups, found the team's condition, the significantly higher than the control group; Group A and group B of the clinical symptoms and signs disappeared time has no obvious dif erence, the dif erence was statistical y significant; ( < 0.05). Conclusion atomization inhalation method is an ef ective method of capil ary bronchitis.%目的:探讨雾化吸入法在小儿毛细支气管炎患者中的应用价值。方法选取患有毛细支气管炎的患儿102例,根据如下情况分组:家长拒绝雾化吸入或婴儿不配合雾化吸入的,常规静脉抗感染,止咳、化痰及对症的,共34例,作为对照组。研究组分为:A组为单纯雾化吸入,共32例;B组为口服药物对症治疗上加用雾化吸入,共36例。收集一般临床资料。结果在治疗第3d,对3组疗效进行评价,发现研究组病情好转率明显高于对照组;A组与B组的临床症状、体征消失时间无明显的差异性,差异有统计学意义(<0.05)。结论雾化吸入法是治疗毛细支气管炎的一种有效的方法。

  15. 观察小儿化痰止咳颗粒治疗小儿支气管炎的疗效%Observation on Curative Effect of the Infantile Phlegm Cough Particles in Child Bronchitis

    Institute of Scientific and Technical Information of China (English)

    李向明; 郭思岐

    2016-01-01

    Objective To observe curative effect of the infantile phlegm cough particles in the child bronchitis.MethodsThis article selected 48 cases of infantile bronchitis patients in the hospital from January, 2014 to May 2015,they were randomly divided into treatment group and control group,control group adopted ammonia bromine treatment, treatment group was treated with infantile phlegm cough particles, comparing the two groups of patients with clinical symptoms.ResultsTwo groups of patients and lung rale disappearing time had significant differences(P<0.05).Conclusion Infantile bronchitis patients with infantile phlegm cough particles after treatment can obviously eliminate adverse factors,improve patients with bronchial inflammation early.%目的:观察小儿化痰止咳颗粒治疗小儿支气管炎的疗效。方法本文选取我院于2014年1月~2015年5月收治的48例小儿支气管炎患者,将其随机分为治疗组和对照组,对照组采用氨溴索治疗,治疗组采用小儿化痰止咳颗粒治疗,对比两组患者的临床症状改善情况。结果两组患者的止咳好转时间以及肺部罗音消失时间指标差异有统计学意义(P<0.05)。结论小儿支气管炎患者采用小儿化痰止咳颗粒治疗后,可以缓解患者的支气管炎病症,消除不良因素影响,促进患者支气管炎症反应及早改善。

  16. Curative effect observation of Sai Nuo Jin atomization inhalation in the treatment of capillary bronchitis%赛诺金雾化吸入治疗毛细支气管炎的疗效观察

    Institute of Scientific and Technical Information of China (English)

    王玉梅

    2015-01-01

    Objective:To observe the clinical curative effect of Sai Nuo Jin oxygen driven atomization inhalation in the treatment of capillary bronchitis.Methods:160 children with capillary bronchitis were selected from July 2012 to December 2013.They were randomly divided into the treatment group and the control group with 80 cases in each.The control group were given anti infection, pyretolysis,preventing phlegm from forming and stopping coughing,antispasmodic asthma,oxygen,cardiac and other treatments. The treatment group were given Sai Nuo Jin oxygen driven atomization inhalation treatment on the basis of the control group.The signs,symptoms and pulmonary rales situation of children in two groups were observed and recorded.Results:The total effective rate of the treatment group was 95.56%;the total effective rate of the control group was 78.57%;the difference was statistically significant(P<0.05).Conclusion:Sai Nuo Jin oxygen driven atomization inhalation in the treatment of capillary bronchitis has obvious effect.It is worth clinical promotion.%目的:观察赛诺金氧驱动雾化吸入治疗毛细支气管炎的临床疗效。方法:2012年7月-2013年12月收治毛细支气管炎患儿160例,随机分为治疗组和对照组,各80例,对照组给予抗感染、退热、化痰止咳、解痉平喘、吸氧、强心等治疗,治疗组在对照组的基础上加赛诺金氧驱动雾化吸入治疗,观察记录两组患儿症状、体征情况。结果:治疗组总有效率100%,对照组总有效率87.5%,差异有统计学意义(P<0.05)。结论:赛诺金氧驱动雾化治疗毛细支气管炎有明显效果,值得临床推广。

  17. Observation on the Effect of the Treatment of Children with Recurrent Asthma Bronchitis%孟鲁司特治疗儿童反复哮喘性支气管炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    侯萍萍

    2016-01-01

    Objective:To discuss effect of montelukast in treatment of children recurrent asthmatic bronchiti. Method:From January to June 2014,200 children with recurrent asthmatic bronchitis were selected as research objects and randomly divided into treatment group and control group. The treatment group was given montelukast,4 mg 1 time per night of oral treatment for 6 months. The control group received placebo treatment. To compare the therapeutic effect between the two groups. Result:During the period of 6 months treatment, breathing frequency of symptoms of the treatment group was less than that of the control group,wheezing onset of the respiration rate was lower,breathe course was shorter. The difference was statistically significant(P<0.05). Conclusion:Montelukast can prevent the happening of the repeated sexual bronchitis asthma children breathing, reduce breathing attack,shorten the breathing course.%目的:探讨孟鲁司特治疗儿童反复哮喘性支气管炎疗效。方法:选取本院2014年1-6月收治的200例反复哮喘性支气管炎患儿作为本次研究的对象,随机数字表法分为治疗组与对照组,治疗组给予孟鲁司特4 mg每晚1次口服,治疗6个月,对照组给予安慰剂治疗,观察两组患儿的治疗效果。结果:在治疗的6个月内,治疗组患儿喘息发作的次数较对照组减少,喘息发作时的平均呼吸次数较对照组降低,喘息发作的平均时间较对照组缩短,比较差异有统计学意义(P<0.05)。结论:孟鲁司特可预防反复哮喘性支气管炎患儿喘息的发生,减低喘息发作的次数,降低喘息发作程度,缩短喘息时间。

  18. Watercress Formula for Chicken Kidney Type Infectious Bronchitis%荆芥组方对鸡肾型传染性支气管炎防治效果观察

    Institute of Scientific and Technical Information of China (English)

    冯善祥

    2011-01-01

    We used the method of randomization and duplication of pathological model to do this research. In order to validate the effects of the compound preparation of Chinese traditional medicine to the avian infectious bronchitis, we divided the 2-week-old AA kreo-chicken into 8 groups (30 chicken for each group), including the investigational drug groups (which include the high dose group and the moderate dose group as well as the low dose group) and the following control groups: the control group of traditional Chinese medicine and the Western medicine group, the vaccine control group and the negative control group as well as the health control group. The chickens were artificially infected with infectious bronchitis virus (IBV) to observe the protection of the compound preparation of Chinese traditional medicine. The results indicated that the compound preparation of Chinese traditional medicine has a great protection to chicken infected by (IBV). Therefore, the compound preparation of Chinese traditional medicine can be used to the prevention and cure of avian infectious bronchitis.%本试验采取随机分组,病理模型复制的方法,试验中将14日龄AA肉雏鸡240只随机分为受试药物组(高、中、低3个剂量)、中药对照组、西药对照组、疫苗对照组、阴性对照组、健康对照组共8个组,每组30只,以验证中药荆芥组方对鸡肾型传染性支气管炎的效果.将试验鸡人T感染肾型传染性支气管炎病毒(IBV),观察中药组方对雏鸡保护作用.结果表明,本组方对肾型传染性支气管炎病毒感染雏鸡具有明显的保护作用,可以用于鸡肾型传染性支气管炎的预防和治疗.

  19. Chronicity and control

    DEFF Research Database (Denmark)

    Whyte, Susan Reynolds

    2012-01-01

    This paper proposes a way of framing the study of ‘noncommunicable diseases’ within the more general area of chronic conditions. Focusing on Africa, it takes as points of departure the situation in Uganda, and the approach to health issues developed by a group of European and African colleagues...... over the years. It suggests a pragmatic analysis that places people's perceptions and practices within a field of possibilities shaped by policy, health care systems, and life conditions. In this field, the dimensions of chronicity and control are the distinctive analytical issues. They lead...... on to consideration of patterns of sociality related to chronic conditions and their treatment....

  20. 十味龙胆花胶囊辅助治疗小儿急性支气管炎疗效观察%Ten flavour gentian flowers capsule auxiliary treatmentof infantile acute bronchitis curative effect observation

    Institute of Scientific and Technical Information of China (English)

    张晓红

    2015-01-01

    目的:观察十味龙胆花胶囊辅助治疗小儿急性支气管炎的临床疗效。方法将小儿急性支气管炎患儿108例,从咳嗽、咳痰、喘息、肺部哮鸣音等方面观察治疗前后和2组间变化,并以记分的形式进行统计学处理。随机分为治疗组、对照组各54例,均采用抗感染、平喘、雾化吸入等综合治疗,治疗组在此基础上加服十味龙胆花胶囊。结果2组治疗后积分均显著高于治疗前(P<0.05);治疗组积分显著高于对照组(P<0.05)总有效率87.0%,对照组总有效率59.3%。两组经统计学分析,差异有统计意义(P<0.05)。结论十味龙胆花胶囊是治疗小儿急性支气管炎的有效药物,有改善急性支气管炎急性发作的咳、痰、喘、炎的作用。%Objective To observe the ten taste auxiliary gentian flowers capsule in the treatment of infantile acute bronchitis curative effect. Methods 108 cases of children with acute bronchitis, children from cough, sputum, breathing and lung wheezing sound observation and changes between the two groups before and after the treatment, and in the form of scoring statistics processing. Were randomly divided into treatment group and the control group (n = 54), adopt anti-infection, smooth wheezing, atomization inhalation comprehensive treatment, the treatment group on the basis of gentian flowers capsule add ten taste. Results two groups after treatment points were significantly higher than before treatment (P <0.05); Integral treatment group is significantly higher than control group (P<0.05), total effective rate 87.0%, control group total effective rate was 59.3%. Statistically significant difference after statistics analysis, the two groups (P<0.05).Conclusion 10 flavour gentian flowers capsule effective therapeutic agents in the treatment of children with acute bronchitis, improved acute bronchitis acute cough, phlegm, asthma, the role of inflammation.

  1. Observation of curative effect of Xiyanping on treating capillarity bronchitis%喜炎平治疗毛细支气管炎60例疗效观察

    Institute of Scientific and Technical Information of China (English)

    马洪英; 唐毅

    2011-01-01

    目的 现察喜炎平对毛细支气管炎的治疗效果.方法 将120例毛细支气管炎患者随机分为治疗组与对照组,每组均为60例,两组患者在吸氧、祛痰的基础上,治疗组用喜炎平治疗,对照组用病毒唑治疗,根据治疗效果进行对比分析.结果 治疗组在发热、喘憋、肺部罗音消失时间缩短等方面优于对照组,差异有显著性(P<0.05).结论 喜炎平抗病毒作用比病毒唑强,治疗毛细支气管炎取得满意疗效,值得临床推广.%Objective To observe Xiyanping's curative effect on capillarity bronchitis. Methods 120 cases with capillarity bronchitis were stochastically divided into two groups, including the treatment group ( 60 cases) and the control group (60 cases). Based on oxygen- breathing and phlegm dispelling, the treatment group was treated with Xiyanping, while the control group with ribavirin. Results The result indicates that the vanishing time for Xiyanping group's fever, suppression of heavy breath and lungs Rales were reduced. Conclusion Xiyanping's anti-virus function is stronger than ribavirin.

  2. Xingsu San Adjustment Treatment of Pediatric Acute Bronchitis 60 cases of Clinical Observation%杏苏散加减治疗小儿急性支气管炎60例临床观察

    Institute of Scientific and Technical Information of China (English)

    崔松涛

    2015-01-01

    目的:探讨杏苏散加减治疗小儿急性支气管炎的效果。方法:把我院收治的小儿支气管炎患儿60例平均分成两组,治疗组用杏苏散加减,对照组应用头孢曲松、地塞米松、病毒性静脉滴注,比较疗效。结果:治疗组痊愈率为95%,对照组为60%,差异明显。结论:杏苏散加减治疗小儿急性支气管炎,疗效满意,且无不良反应,较之西药治疗可以有效缩短治疗时间,避免患儿病情加重,减轻患儿痛苦,值得临床工作者推广使用。%Objective:To investigate the Xingsu San Decoction for the treatment of children with Acute Bronchitis effect. Methods: Our Hospital pediatric bronchiolitis were 60 patients divided into two groups, treatment group with apricot Su powder the addition and subtraction, control group used cephalosporin ceftriaxone, dexamethasone,virus of intravenous injection,the curative effect was compared. Results:The cure rate of treatment group was 95%,60% in the control group, the difference is obvious.Conclusion:Xingsu San Decoction for the treatment of acute bronchitis in children, the curative effect is satisfied, and no adverse reactions,compared to western medicine treatment can effectively shorten the treatment time, avoid exacerbations in children, reduce the pain of patients, it is worth to promote the use of clinical workers.

  3. Pharmaceutical Care for One Elderly Patient with Acute Bronchitis Associated with Cerebral Arteriosclerosis%1例老年急性支气管炎并脑动脉硬化患者的药学监护

    Institute of Scientific and Technical Information of China (English)

    张富东

    2014-01-01

    目的:探讨临床药师参与药物治疗方案的制订与药学监护的方法。方法:介绍临床药师参与1例老年急性支气管炎并脑动脉硬化患者的治疗过程,分析、评价治疗方案,提出药学建议,并进行药学监护。结果:通过药师的介入与参与可使患者的治疗更加顺利,真正做到了对老年急性支气管炎并脑动脉硬化患者的治疗个体化,使患者顺利治愈出院。结论:临床药师的参与可以协助医师制订安全、有效的治疗方案。%OBJECTIVE:To explore the approaches for clinical pharmacist to participate in the formulation of treatment regi-men and carry out pharmaceutical care. METHODS:Clinical pharmacist’involvement in the treatment of one elderly patient with acute bronchitis associated with cerebral arteriosclerosis was introduced with regard to his efforts in analyzing and evaluating thera-peutic regimen,putting forward pharmacy suggestion and providing pharmaceutical care. RESULTS:Pharmacist’s involvement con-tributed to smooth treatment of the patient and effectuated the individualized treatment for the elderly patient with acute bronchitis associated with cerebral arteriosclerosis and the patient was cured and discharged from hospital. CONCLUSIONS:Clinical pharma-cist’s involvement can help clinical physicians in formulating safe and effective treatment regimen.

  4. Chronic Condition Data Warehouse

    Data.gov (United States)

    U.S. Department of Health & Human Services — The CMS Chronic Condition Data Warehouse (CCW) provides researchers with Medicare and Medicaid beneficiary, claims, and assessment data linked by beneficiary across...

  5. Sleep and Chronic Disease

    Science.gov (United States)

    ... message, please visit this page: About CDC.gov . Sleep About Us About Sleep Key Sleep Disorders Sleep ... Sheets Data & Statistics Projects and Partners Resources Events Sleep and Chronic Disease Recommend on Facebook Tweet Share ...

  6. What Is Chronic Pain?

    Medline Plus

    Full Text Available ... Contact Us Shop FAQs The Art of Pain Management Resources Going to the ER Glossary Surveys What We Have Learned Communication Tools Videos Pain Management Programs Resource Guide to Chronic Pain Treatments Pain ...

  7. What Is Chronic Pain?

    Medline Plus

    Full Text Available Already a member? Log In or Sign Up Home About Us Support the ACPA Contact Us Shop ... for Understanding Pain September is Pain Awareness Month Home Pain Management Tools Videos What Is Chronic Pain? ...

  8. What Is Chronic Pain?

    Medline Plus

    Full Text Available ... chronic pain there may be no apparent physical injury or illness to explain it. The physician and ... expected period of healing for an illness or injury. You can experience pain even if you are ...

  9. Chronic rhinosinusitis pathogenesis.

    Science.gov (United States)

    Stevens, Whitney W; Lee, Robert J; Schleimer, Robert P; Cohen, Noam A

    2015-12-01

    There are a variety of medical conditions associated with chronic sinonasal inflammation, including chronic rhinosinusitis (CRS) and cystic fibrosis. In particular, CRS can be divided into 2 major subgroups based on whether nasal polyps are present or absent. Unfortunately, clinical treatment strategies for patients with chronic sinonasal inflammation are limited, in part because the underlying mechanisms contributing to disease pathology are heterogeneous and not entirely known. It is hypothesized that alterations in mucociliary clearance, abnormalities in the sinonasal epithelial cell barrier, and tissue remodeling all contribute to the chronic inflammatory and tissue-deforming processes characteristic of CRS. Additionally, the host innate and adaptive immune responses are also significantly activated and might be involved in pathogenesis. Recent advancements in the understanding of CRS pathogenesis are highlighted in this review, with special focus placed on the roles of epithelial cells and the host immune response in patients with cystic fibrosis, CRS without nasal polyps, or CRS with nasal polyps. PMID:26654193

  10. Chronic penile strangulation

    Directory of Open Access Journals (Sweden)

    Lopes Roberto I

    2003-01-01

    Full Text Available Chronic penile strangulation is exceedingly rare with only 5 cases previously reported. We report an additional case of progressive penile lymphedema due to chronic intermittent strangulation caused by a rubber band applied to the penile base for 6 years. A 49-year-old man presented incapacity to exteriorize the glans penis. For erotic purposes, he had been using a rubber-enlarging band placed in the penile base for 6 years. With chronic use, he noticed that his penis swelled. Physical examination revealed lymphedema of the penis, phimosis and a stricture in the penile base. The patient was submitted to circumcision and the lymphedema remained stable 10 months postoperatively. Chronic penile incarceration usually causes penile lymphedema and urinary disturbance. Treatment consists of removal of foreign devices and surgical treatment of lymphedema.

  11. Chronic Conditions Dashboard

    Data.gov (United States)

    U.S. Department of Health & Human Services — The CMS Chronic Conditions Dashboard presents statistical views of information on the prevalence, utilization and Medicare spending for Medicare beneficiaries with...

  12. What Is Chronic Pain?

    Medline Plus

    Full Text Available ... after a period of time the spinal cord has changed, after a period of time there are ... absence of an apparent cause. But chronic pain has a physiological or neurological basis even when we ...

  13. Chronic Kidney Disease

    Science.gov (United States)

    You have two kidneys, each about the size of your fist. Their main job is to filter wastes and excess water out of ... help control blood pressure, and make hormones. Chronic kidney disease (CKD) means that your kidneys are damaged ...

  14. Chronic Conditions Chartbook

    Data.gov (United States)

    U.S. Department of Health & Human Services — Chronic Conditions among Medicare Beneficiaries is a chartbook prepared by the Centers for Medicare and Medicaid Services and created to provide an overview of...

  15. What Is Chronic Pain?

    Medline Plus

    Full Text Available ... Programs Resource Guide to Chronic Pain Treatments Pain Awareness Toolkits Partners for Understanding Pain September is Pain Awareness Month Home Pain Management Tools Videos What Is ...

  16. Chronic Fatigue Syndrome

    Science.gov (United States)

    Chronic fatigue syndrome (CFS) is a disorder that causes extreme fatigue. This fatigue is not the kind of tired feeling that ... activities. The main symptom of CFS is severe fatigue that lasts for 6 months or more. You ...

  17. Chronic dysimmune neuropathies: Beyond chronic demyelinating polyradiculoneuropathy

    Directory of Open Access Journals (Sweden)

    Khadilkar Satish

    2011-01-01

    Full Text Available The spectrum of chronic dysimmune neuropathies has widened well beyond chronic demyelinating polyradiculoneuropathy (CIDP. Pure motor (multifocal motor neuropathy, sensorimotor with asymmetrical involvement (multifocal acquired demylinating sensory and motor neuropathy, exclusively distal sensory (distal acquired demyelinating sensory neuropathy and very proximal sensory (chronic immune sensory polyradiculopathy constitute the variants of CIDP. Correct diagnosis of these entities is of importance in terms of initiation of appropriate therapy as well as prognostication of these patients. The rates of detection of immune-mediated neuropathies with monoclonal cell proliferation (monoclonal gammopathy of unknown significance, multiple myeloma, etc. have been facilitated as better diagnostic tools such as serum immunofixation electrophoresis are being used more often. Immune neuropathies associated with malignancies and systemic vasculitic disorders are being defined further and treated early with better understanding of the disease processes. As this field of dysimmune neuropathies will evolve in the future, some of the curious aspects of the clinical presentations and response patterns to different immunosuppressants or immunomodulators will be further elucidated. This review also discusses representative case studies.

  18. Mathematical model of mean age, mean arsenic dietary dose and age-specific prevalence rate from endemic chronic arsenic poisoning: a human toxicology study

    Energy Technology Data Exchange (ETDEWEB)

    Zald' ivar, R.; Ghai, G.L.

    1980-01-01

    The aim of this investigation was to develop a mathematical model of mean age, mean arsenic dietary dose, and age-specific prevalence rate for endemic chronic arsenic poisoning. Data on mean age (years), mean arsenic dietary dose (mg/kg body weight/day), and age-specific prevalence rate per 100,000 population for endemic chronic arsenic poisoning in Antofagasta Commune, northern Chile, for the 1968 to 1971 period, were collected. Endemic chronic arsenic poisoning means here chronic arsenical dermatosis associated with marked or sever symptoms (or signs) of chronic arsenic poisoning (chronic diarrhea, hepatic cirrohsis, chronic bronchitis, bronchiectasis, recurrent broncho-pneumonia, cardiomegaly, systemic occlusive arterial disease, cerebral thrombosis, etc.). There was a strong positive correlation between age-specific pevalence rate per 100,000 population and mean arsenic dose (r = + 0.9593) and a negative correlation between prevalence rate and mean age (r = 0.8789). These findings show that the prevalence rate declines with the advancing age and increases with the increase of arsenic dose. A multiple linear regression model E(y) = alpha + beta X1 + gamma X2, where y represents the age-specific prevalence rate per 100,000 population, X1 the mean arsenic dose, and X2 the mean age, was fitted to the data. The estimates of the parameters (alpha, beta, and gamma) were obtained by minimizing the residual sum of squares sigma(y - alpha - beta X1 - gamma X2)2. The following multiple linear regression equation was obtained: Y = 202.161 + 8452.455 X1 - 2.394 X2. Of the total variability in the prevalence rate, 96.22 percent was accounted for by the multiple regression.

  19. Idiopathic chronic eosinophilic pneumonia

    OpenAIRE

    Cordier Jean-François; Marchand Eric

    2006-01-01

    Abstract Idiopathic chronic eosinophilic pneumonia (ICEP) is characterized by subacute or chronic respiratory and general symptoms, alveolar and/or blood eosinophilia, and peripheral pulmonary infiltrates on chest imaging. Eosinophilia is present in most cases, usually in excess of 1000/mm3. In absence of significant blood eosinophilia, a diagnosis of ICEP is supported by the demonstration of bronchoalveolar lavage eosinophilia. ICEP is typically associated with eosinophil counts higher than ...

  20. Experimental chronic periodontitis morphogenesis

    OpenAIRE

    Schneider S.A.

    2011-01-01

    Morphogenesis of periodontium tissue in a model of chronic periodontitis was studied. Adult Wistar rats wereused in a model; chronic periodontitis was developed through mastication-related loading decrease. Histological assessmentof periodontium tissue was conducted at Days 7, 14, 21 and 30. It was demonstrated that dystrophic tissue changes prevailover the inflammatory one in this particular experimental model. The structural elements of periodontium were involved intothe pathologic process ...

  1. Chronic Airflow Obstruction in a Black African Population: Results of BOLD Study, Ile-Ife, Nigeria.

    Science.gov (United States)

    Obaseki, Daniel O; Erhabor, Gregory E; Gnatiuc, Louisa; Adewole, Olufemi O; Buist, Sonia A; Burney, Peter G

    2016-01-01

    Global estimates suggest that Chronic Obstructive Pulmonary Disease (COPD) is emerging as a leading cause of death in developing countries but there are few spirometry-based general population data on its prevalence and risk factors in sub-Saharan Africa. We used the Burden of Obstructive Lung Disease (BOLD) protocol to select a representative sample of adults aged 40 years and above in Ile-Ife, Nigeria. All the participants underwent spirometry and provided information on smoking history, biomass and occupational exposures as well as diagnosed respiratory diseases and symptoms. Chronic Airflow Obstruction (CAO) was defined as the ratio of post-bronchodilator (BD) one second Forced Expiratory Volume (FEV1) to Forced Vital Capacity (FVC) below the lower limit of normal (LLN) of the population distribution for FEV1/FVC. The overall prevalence of obstruction (post-BD FEV1/FVC < LLN) was 7.7% (2.7% above LLN) using Global Lung Function Initiative (GLI) equations. It was associated with few respiratory symptoms; 0.3% reported a previous doctor-diagnosed chronic bronchitis, emphysema or COPD. Independent predictors included a lack of education (OR 2.5, 95% CI: 1.0, 6.4) and a diagnosis of either TB (OR 23.4, 95% CI: 2.0, 278.6) or asthma (OR 35.4, 95%CI: 4.9, 255.8). There was no association with the use of firewood or coal for cooking or heating. The vast majority of this population (89%) are never smokers. We conclude that the prevalence of CAO is low in Ile-Ife, Nigeria and unrelated to biomass exposure. The key independent predictors are poor education, and previous diagnosis of tuberculosis or asthma. PMID:26451840

  2. Expression profiles of hydrophobic surfactant proteins in children with diffuse chronic lung disease

    Directory of Open Access Journals (Sweden)

    Guttentag Susan

    2005-07-01

    Full Text Available Abstract Background Abnormalities of the intracellular metabolism of the hydrophobic surfactant proteins SP-B and SP-C and their precursors may be causally linked to chronic childhood diffuse lung diseases. The profile of these proteins in the alveolar space is unknown in such subjects. Methods We analyzed bronchoalveolar lavage fluid by Western blotting for SP-B, SP-C and their proforms in children with pulmonary alveolar proteinosis (PAP, n = 15, children with no SP-B (n = 6, children with chronic respiratory distress of unknown cause (cRD, n = 7, in comparison to children without lung disease (n = 15 or chronic obstructive bronchitis (n = 19. Results Pro-SP-B of 25–26 kD was commonly abundant in all groups of subjects, suggesting that their presence is not of diagnostic value for processing defects. In contrast, pro-SP-B peptides cleaved off during intracellular processing of SP-B and smaller than 19–21 kD, were exclusively found in PAP and cRD. In 4 of 6 children with no SP-B, mutations of SFTPB or SPTPC genes were found. Pro-SP-C forms were identified at very low frequency. Their presence was clearly, but not exclusively associated with mutations of the SFTPB and SPTPC genes, impeding their usage as candidates for diagnostic screening. Conclusion Immuno-analysis of the hydrophobic surfactant proteins and their precursor forms in bronchoalveolar lavage is minimally invasive and can give valuable clues for the involvement of processing abnormalities in pediatric pulmonary disorders.

  3. Time to First Morning Cigarette and Risk of Chronic Obstructive Pulmonary Disease: Smokers in the PLCO Cancer Screening Trial.

    Directory of Open Access Journals (Sweden)

    Kristin A Guertin

    Full Text Available Time to first cigarette (TTFC after waking is an indicator of nicotine dependence. The association between TTFC and chronic obstructive pulmonary disease (COPD, the third leading cause of death in the United States, has not yet been reported.We investigated the cross-sectional association between TTFC and prevalent COPD among 6,108 current smokers in the Prostate, Lung, Colorectal, and Ovarian (PLCO Cancer Screening Trial. COPD was defined as a self-reported diagnosis of emphysema, chronic bronchitis, or both. Current smokers in PLCO reported TTFC, the amount of time they typically waited before smoking their first cigarette of the day after waking, in four categories: ≤ 5, 6-30, 31-60, or > 60 minutes. We used logistic regression models to investigate the association between TTFC and prevalent COPD with adjustments for age, gender, race, education, and smoking (cigarettes/day, years smoked during lifetime, pack-years, age at smoking initiation, and prior lung cancer diagnosis.COPD was reported by 19% of these 6,108 smokers. Individuals with the shortest TTFC had the greatest risk of COPD; compared to those with the longest TTFC (> 60 minutes the adjusted odds ratios (OR and 95% confidence intervals (CI for COPD were 1.48 (95% CI, 1.15-1.91, 1.64 (95% CI, 1.29-2.08, 2.18 (95% CI, 1.65-2.87 for those with TTFC 31-60 minutes, 6-30 minutes, and ≤ 5 minutes, respectively (P-trend 60 minutes, the adjusted OR (95% CI was 2.29 (1.69-3.12 for emphysema and 2.99 (1.95-4.59 for chronic bronchitis.Current smokers with shorter TTFC have increased risk of COPD compared to those with longer TTFC, even after comprehensive adjustment for established smoking covariates. Future epidemiologic studies, including prospective designs, should incorporate TTFC to better assess disease risk and evaluate the potential utility of TTFC as a COPD screening tool for smokers in the clinical setting.

  4. Hypertension in Chronic Glomerulonephritis.

    Science.gov (United States)

    Ihm, Chun-Gyoo

    2015-12-01

    Chronic glomerulonephritis (GN), which includes focal segmental glomerulosclerosis and proliferative forms of GN such as IgA nephropathy, increases the risk of hypertension. Hypertension in chronic GN is primarily volume dependent, and this increase in blood volume is not related to the deterioration of renal function. Patients with chronic GN become salt sensitive as renal damage including arteriolosclerosis progresses and the consequent renal ischemia causes the stimulation of the intrarenal renin-angiotensin-aldosterone system(RAAS). Overactivity of the sympathetic nervous system also contributes to hypertension in chronic GN. According to the KDIGO guideline, the available evidence indicates that the target BP should be ≤140mmHg systolic and ≤90mmHg diastolic in chronic kidney disease patients without albuminuria. In most patients with an albumin excretion rate of ≥30mg/24 h (i.e., those with both micro-and macroalbuminuria), a lower target of ≤130mmHg systolic and ≤80mmHg diastolic is suggested. The use of agents that block the RAAS system is recommended or suggested in all patients with an albumin excretion rate of ≥30mg/ 24 h. The combination of a RAAS blockade with a calcium channel blocker and a diuretic may be effective in attaining the target BP, and in reducing the amount of urinary protein excretion in patients with chronic GN. PMID:26848302

  5. [Effect of rehabilitation using antihomotoxic drug together with energy stabilizing electromagnetic therapy on morphological, biochemical, and system immunity indices in children with recurrent bronchitis].

    Science.gov (United States)

    Lyseniuk, V P; Naumova, M I; Shapoval, V N

    2012-01-01

    There is now good evidence that the use of electromagnetic millimeter waves the following curative effects: analgesic, normalization of relations or increased formation of neurohumoral substances. The introduction of a therapeutic practice complex biological drugs that trigger, not overwhelming the body auxiliary immunological reaction, based on the activation of the regulation clones of T-lymphocytes and helper functions, is an important step in achieving a qualitatively level of health patients with chronic disease.

  6. Use Thread Embedding in Tanzhong Point to Treat 35 Cases of Acute and Chronic Bronchitis%膻中穴埋线治疗急慢性支气管炎35例

    Institute of Scientific and Technical Information of China (English)

    王尚威

    2001-01-01

    @@ 笔者近几年来运用中医的整体观念和辨证论治的原则,采用内病外治的方法,用健康猪躯干毛发行膻中穴穴位埋线,治疗急慢性支气管炎,收到很好的疗效,现报告如下.

  7. The effect of Inhalation Terbutaline Sulphate in Treatment Patients with chronic Asthmatic Bronchitis%硫酸特布他林雾化吸入治疗慢性喘息性支气管炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    杨珺楠; 向平超; 张二明

    2005-01-01

    目的观察硫酸特布他林雾化吸入治疗慢性喘息性支气管炎的临床效果.方法将46例慢性喘息性支气管炎的患者随机分成两组,硫酸特布他林组治疗组26例,生理盐水对照组20例,分别给予硫酸特布他林0.25mg加入0.9%生理盐水4ml雾化吸入,对照组为0.9%生理水4ml雾化吸入.雾化前后分别观察患者喘憋症状、肺部干罗音、心率、血气(PaO2、PaCO2、PH)和肺功能FEV1.0、PVC、PEF.结果硫酸特布他林雾化吸入对慢性喘息性支气管炎临床症状和体征有明显改善,血氧分压由62.73mmHg提高到73.3mmHg.肺功能FEV1.0、FVC、PEF明显改善,治疗组明显优于对照组,且副作用小.结论硫酸特布他林雾化吸入能有效缓解支气管痉挛,改善患者的临床症状,及通气功能.

  8. Clinical observation of chronic bronchitis treated with application therapy during the hottest and coldest days of the year%“伏九贴敷疗法”治疗慢性支气管炎的临床观察

    Institute of Scientific and Technical Information of China (English)

    赵欲晓

    2010-01-01

    @@ Application therapy during the hottest and coldest days of the year is a kind of external therapy of Chinese medicine in which a specifically-prepared Chinese herbal plaster is applied on the specific points of human body during the three ten-day periods of the hottest days in summer, from mid-July to mid-August,and the three nine-day periods after the winter solstice,reputed to be the coldest days of the year, including two sessions of treatment, named the treatment in summer for disorder in winter and prevention in winter for disorder in winter.

  9. Hereditary chronic pancreatitis

    Directory of Open Access Journals (Sweden)

    Mössner Joachim

    2007-01-01

    Full Text Available Abstract Hereditary chronic pancreatitis (HCP is a very rare form of early onset chronic pancreatitis. With the exception of the young age at diagnosis and a slower progression, the clinical course, morphological features and laboratory findings of HCP do not differ from those of patients with alcoholic chronic pancreatitis. As well, diagnostic criteria and treatment of HCP resemble that of chronic pancreatitis of other causes. The clinical presentation is highly variable and includes chronic abdominal pain, impairment of endocrine and exocrine pancreatic function, nausea and vomiting, maldigestion, diabetes, pseudocysts, bile duct and duodenal obstruction, and rarely pancreatic cancer. Fortunately, most patients have a mild disease. Mutations in the PRSS1 gene, encoding cationic trypsinogen, play a causative role in chronic pancreatitis. It has been shown that the PRSS1 mutations increase autocatalytic conversion of trypsinogen to active trypsin, and thus probably cause premature, intrapancreatic trypsinogen activation disturbing the intrapancreatic balance of proteases and their inhibitors. Other genes, such as the anionic trypsinogen (PRSS2, the serine protease inhibitor, Kazal type 1 (SPINK1 and the cystic fibrosis transmembrane conductance regulator (CFTR have been found to be associated with chronic pancreatitis (idiopathic and hereditary as well. Genetic testing should only be performed in carefully selected patients by direct DNA sequencing and antenatal diagnosis should not be encouraged. Treatment focuses on enzyme and nutritional supplementation, pain management, pancreatic diabetes, and local organ complications, such as pseudocysts, bile duct or duodenal obstruction. The disease course and prognosis of patients with HCP is unpredictable. Pancreatic cancer risk is elevated. Therefore, HCP patients should strongly avoid environmental risk factors for pancreatic cancer.

  10. HIGH-Resolution CT in Chronic Pulmonary Changes after Mustard Gas Exposure

    International Nuclear Information System (INIS)

    Purpose: To identify the findings of high-resolution CT (HRCT) of the lung in patients with previous sulfur mustard gas exposure, and to correlate these findings with clinical and chest X-ray (CXR) results. Material and Methods: 50 consecutive patients were studied prospectively. The clinical data were recorded. Standard p.a. CXR and HRCT of the lung and spirometry were performed. The findings of CXR, HRCT and clinical and spirometry results were scored between 0 and 3 according to the severity of the findings. Results: HRCT abnormality was detected in all 50 patients (100%), while CXR was abnormal in 40 patients (80%). The most common HRCT findings was airway abnormalities (bronchial wall thickening in 100% of cases). Other important findings were suggestive of interstitial lung disease (ILD) (80%), bronchiectasis (26%), and emphysema (24%). A statistically significant correlation was found between the severity of clinical presentation and that of the HCTR scores in patients with bronchiectasis, bronchitis and ILD (p< 0.05), but not with severity scores of HRCT in patients with emphysema. No significant correlation was found between severity scores of CXR findings. HRCT evidence of bronchial wall thickening and with a lower frequency ILD were present despite normal CXR in 20% of the patients. Conclusion: The results of this study suggest that bronchial wall thickening, ILD and emphysema are common chronic pulmonary sequelae of sulfur mustard injury. HRCT of the chest should be considered as the imaging modality of choice in chemical war injury

  11. HIGH-Resolution CT in Chronic Pulmonary Changes after Mustard Gas Exposure

    Energy Technology Data Exchange (ETDEWEB)

    Bagheri, M.H.; Mostafavi, S.H. [Shiraz Univ. of Medical Siences (Iran, Islamic Republic of). Dept. of Radiology; Hosseini, S.K. [Shiraz Univ. of Medical Siences (Iran, Islamic Republic of). Dept. of Internal Medicine; Alavi, S.A. [Medical Center for Chemical Warfare Victims Foundation, Shiraz (Iran, Islamic Republic of)

    2003-05-01

    Purpose: To identify the findings of high-resolution CT (HRCT) of the lung in patients with previous sulfur mustard gas exposure, and to correlate these findings with clinical and chest X-ray (CXR) results. Material and Methods: 50 consecutive patients were studied prospectively. The clinical data were recorded. Standard p.a. CXR and HRCT of the lung and spirometry were performed. The findings of CXR, HRCT and clinical and spirometry results were scored between 0 and 3 according to the severity of the findings. Results: HRCT abnormality was detected in all 50 patients (100%), while CXR was abnormal in 40 patients (80%). The most common HRCT findings was airway abnormalities (bronchial wall thickening in 100% of cases). Other important findings were suggestive of interstitial lung disease (ILD) (80%), bronchiectasis (26%), and emphysema (24%). A statistically significant correlation was found between the severity of clinical presentation and that of the HCTR scores in patients with bronchiectasis, bronchitis and ILD (p< 0.05), but not with severity scores of HRCT in patients with emphysema. No significant correlation was found between severity scores of CXR findings. HRCT evidence of bronchial wall thickening and with a lower frequency ILD were present despite normal CXR in 20% of the patients. Conclusion: The results of this study suggest that bronchial wall thickening, ILD and emphysema are common chronic pulmonary sequelae of sulfur mustard injury. HRCT of the chest should be considered as the imaging modality of choice in chemical war injury.

  12. Management of chronic paronychia

    Directory of Open Access Journals (Sweden)

    Vineet Relhan

    2014-01-01

    Full Text Available Chronic paronychia is an inflammatory disorder of the nail folds of a toe or finger presenting as redness, tenderness, and swelling. It is recalcitrant dermatoses seen commonly in housewives and housemaids. It is a multifactorial inflammatory reaction of the proximal nail fold to irritants and allergens. Repeated bouts of inflammation lead to fibrosis of proximal nail fold with poor generation of cuticle, which in turn exposes the nail further to irritants and allergens. Thus, general preventive measures form cornerstone of the therapy. Though previously anti-fungals were the mainstay of therapy, topical steroid creams have been found to be more effective in the treatment of chronic paronychia. In recalcitrant cases, surgical treatment may be resorted to, which includes en bloc excision of the proximal nail fold or an eponychial marsupialization, with or without nail plate removal. Newer therapies and surgical modalities are being employed in the management of chronic paronychia. In this overview, we review recent epidemiological studies, present current thinking on the pathophysiology leading to chronic paronychia, discuss the challenges chronic paronychia presents, and recommend a commonsense approach to management.

  13. Autoantibodies in chronic pancreatitis

    DEFF Research Database (Denmark)

    Rumessen, J J; Marner, B; Pedersen, N T;

    1985-01-01

    In 60 consecutive patients clinically suspected of having chronic pancreatitis the serum concentration of the immunoglobulins (IgA, IgG, IgM), the IgG- and IgA-type non-organ-specific autoantibodies against nuclear material (ANA), smooth and striated muscle, mitochondria, basal membrane, and reti......In 60 consecutive patients clinically suspected of having chronic pancreatitis the serum concentration of the immunoglobulins (IgA, IgG, IgM), the IgG- and IgA-type non-organ-specific autoantibodies against nuclear material (ANA), smooth and striated muscle, mitochondria, basal membrane......, and reticulin, and the IgG- and IgA-type pancreas-specific antibodies against islet cells, acinus cells, and ductal cells (DA) were estimated blindly. In 23 of the patients chronic pancreatitis was verified, whereas chronic pancreatitis was rejected in 37 patients (control group). IgG and IgA were found...... in significantly higher concentrations in the patients with chronic pancreatitis than in the control group but within the normal range. ANA and DA occurred very frequently in both groups but with no statistical difference. Other autoantibodies only occurred sporadically. The findings of this study do not support...

  14. Chronic daily headaches

    Directory of Open Access Journals (Sweden)

    Fayyaz Ahmed

    2012-01-01

    Full Text Available Chronic Daily Headache is a descriptive term that includes disorders with headaches on more days than not and affects 4% of the general population. The condition has a debilitating effect on individuals and society through direct cost to healthcare and indirectly to the economy in general. To successfully manage chronic daily headache syndromes it is important to exclude secondary causes with comprehensive history and relevant investigations; identify risk factors that predict its development and recognise its sub-types to appropriately manage the condition. Chronic migraine, chronic tension-type headache, new daily persistent headache and medication overuse headache accounts for the vast majority of chronic daily headaches. The scope of this article is to review the primary headache disorders. Secondary headaches are not discussed except medication overuse headache that often accompanies primary headache disorders. The article critically reviews the literature on the current understanding of daily headache disorders focusing in particular on recent developments in the treatment of frequent headaches.

  15. Omalizumab for chronic urticaria

    DEFF Research Database (Denmark)

    Ivyanskiy, Ilya; Sand, Carsten; Thomsen, Simon Francis

    2012-01-01

    urticaria. We present a case series of 19 patients with chronic urticaria treated in a university department with omalizumab and give an overview of the existing literature comprising an additional 59 cases as well as a total of 139 patients enrolled in two randomized controlled trials comparing omalizumab...... with placebo. The collective evidence points to omalizumab as a safe and effective treatment option for patients with chronic urticaria who do not sufficiently respond to standard therapy as recommended by existing guidelines.......Omalizumab is a recombinant humanized monoclonal antibody that blocks the high-affinity Fc receptor of IgE. Omalizumab has been approved for the treatment of moderate to severe asthma; however, there is currently more and more data showing promising results in the management also of chronic...

  16. 慢性咳嗽的相关疾病及其治疗现状%Related diseases and treatment status of chronic cough

    Institute of Scientific and Technical Information of China (English)

    徐俪颖; 骆仙芳; 王会仍

    2010-01-01

    This article classified the chronic cough by its properties of dry cough or wet cough and summarizes the etiology and pathogenesis,the diagnosis and differentiation as well as the treatment status of related diseases of chronic cough for clinical reference,such as cough variant asthma,eosinophilic bronchitis,gastro-esophageal reflux cough,upper airway cough syndrome,postinfectious cough,atopic cough,cough related by ACEI,psychogenic cough,chronic obstructive pulmonary disease and other organic pulmonary disease with low incidence of cough.%本文对慢性咳嗽干性或湿性的性质进行病因分类,并对咳嗽变异性哮喘、嗜酸粒细胞性支气管炎、胃食管反流性咳嗽、上呼吸道咳嗽综合征、感染后咳嗽、特应性咳嗽、血管紧张素转换酶抑制剂所致的咳嗽、心理性咳嗽、慢性阻塞性肺疾病及其他咳嗽发生率较少的器质性肺部疾病的病因病机、临床诊断和鉴别诊断及其治疗现状进行综述,以供临床参考.

  17. Chronic urticaria: recent advances.

    Science.gov (United States)

    Greaves, Malcolm W; Tan, Kian Teo

    2007-10-01

    Chronic urticaria is an umbrella term, which encompasses physical urticarias, chronic "idiopathic" urticaria and urticarial vasculitis. It is important to recognize patients with physical urticarias as the investigation and treatment differs in important ways from patients with idiopathic chronic urticaria or urticarial vasculitis. Although relatively uncommon, urticarial vasculitis is an important diagnosis to make and requires histological confirmation by biopsy. Underlying systemic disease and systemic involvement, especially of the kidneys, should be sought. It is now recognized that chronic "idiopathic" urticaria includes a subset with an autoimmune basis caused by circulating autoantibodies against the high affinity IgE receptor (FceR1) and less commonly against IgE. Although the autologous serum skin test has been proven useful in prompting search for and characterization of circulating wheal-producing factors in chronic urticaria, its specificity as a screening test for presence of functional anti-FceR1 is low, and confirmation by demonstration of histamine-releasing activity in the patient's serum must be the benchmark test in establishing this diagnosis. Improved screening tests are being sought; for example, ability of the chronic urticaria patient's serum to evoke expression of CD 203c on donor human basophils is showing some promise. The strong association between autoimmune thyroid disease and autoimmune urticaria is also an area of ongoing research. Drug treatment continues to be centered on the H1 antihistamines, and the newer second-generation compounds appear to be safe and effective even in off-label dosage. Use of systemic steroids should be confined to special circumstances such as tapering regimens for acute flare-ups. Use of leukotriene antagonists is becoming popular, but the evidence for efficacy is conflicting. Cyclosporin is also effective and can be used in selected cases of autoimmune urticaria, and it is also effective in non

  18. Chronic lead poisoning

    Energy Technology Data Exchange (ETDEWEB)

    Hess, K.; Straub, P.W.

    1974-02-19

    A detailed description is given of the complex pathological picture observed in the case of a worker with 30 years' occupational exposure to lead in an accumulator factory (evolution of the disease, clinical findings, autopsy). In spite of a typical clinical picture, lead is not held responsible for the terminal encephalopathy, in view of the fact that Alzheimer's syndrome was discovered at autopsy. However, the neurovegetative asthenia and progressive kidney disease without hypertonia, but with uraemia, which preceded the encephalopathy are in all probability due to chronic lead poisoning. The article discusses the diagnosis and symptomatology of chronic lead poisoning, encephalopathy and kidney disease.

  19. Omalizumab for chronic urticaria

    DEFF Research Database (Denmark)

    Ivyanskiy, Ilya; Sand, Carsten; Thomsen, Simon Francis

    2012-01-01

    urticaria. We present a case series of 19 patients with chronic urticaria treated in a university department with omalizumab and give an overview of the existing literature comprising an additional 59 cases as well as a total of 139 patients enrolled in two randomized controlled trials comparing omalizumab......Omalizumab is a recombinant humanized monoclonal antibody that blocks the high-affinity Fc receptor of IgE. Omalizumab has been approved for the treatment of moderate to severe asthma; however, there is currently more and more data showing promising results in the management also of chronic...

  20. Chronic unilateral vestibular loss.

    Science.gov (United States)

    Kerber, K A

    2016-01-01

    Chronic unilateral vestibular loss is a condition defined by the presence of reduced function of the peripheral vestibular system on one side, which has generally persisted for 3 or more months. The deficit is demonstrated by a reduction of the vestibular-ocular reflex either at the bedside or on laboratory testing. Though some patients with chronic vestibular loss have disabling symptoms, others are asymptomatic. Causes include a viral/postviral disorder, Menière's disease, structural lesions, ischemia, and trauma. Any other systemic or genetic disorder would be expected to involve both sides at some point. PMID:27638074

  1. [Histaminergic angioedema and chronic urticaria].

    Science.gov (United States)

    Hacard, Florence; Nosbaum, Audrey; Bensaid, Benoit; Nicolas, Jean-François; Augey, Frédéric; Goujon, Catherine; Bérard, Frédéric

    2015-01-01

    Most angioedemas are histaminergic and correspond to deep urticarial swelling. Recurrent histaminergic angioedema led to the diagnosis of chronic urticaria, even when there are no superficial associated hives. Chronic urticaria is a benign disease, and autoimmune in 40 % of cases. The occurrence of angioedema in chronic urticaria is not a sign of severity. The occurrence of angioedema in chronic urticaria is associated with a longer duration of urticarial disease. NSAIDs and/or systemic corticotherapy are classic triggers of angioedema in chronic urticaria. In the absence of clinical endpoints, there is no need to make further assessment in chronic urticaria good responders to antihistamines.

  2. 高渗盐水雾化吸入治疗毛细支气管炎临床观察%Clinical observation on hypertonic saline aerosol inhalation in treatment of capillary bronchitis

    Institute of Scientific and Technical Information of China (English)

    成红霞; 彭小红; 魏惠兰; 李萍; 韩玲; 赵永芳

    2013-01-01

    Objective To discuss the treatment effect of atomizing inhaled hypertonic saline and ammonia bromine treatment for capillary bronchitis .Methods Totally 60 cases of capillary bronchitis patients were randomly divided into hypertonic saline group ( therapy group ) , ammonia bromine group(control group 1) and conventional group(group 2) with 20 cases in each group.Control group 2 was only given conventional treatment .On the basis of conventional treatment , control group 1 and therapy group was provided with atomization inhaling ammonia bromine 7.5 mg and hypertonic saline 4 ml, respectively.They were given one time every 8 hours(q8h) and the course was 1 week.Comparison was made in clinical coughing , gasping suppress , pulmonary symptoms disappearance time and hospital stay among three groups .Results All of 60 cases were cured and discharged , and the therapeutic effect of the therapy group ( hypertonic saline group) was significantly superior to that of the other two groups .There were statistical differences in wheezing disappearance , cough disappearance , sign disappearance and hospitalization stay among three groups ( t1 value was -9.173, -3.252, -9.672 and -3.968 respectively, all P<0.01;t2 value was -7.952, -2.0433, -8.114 and -4.793 respectively,all P<0.01) Conclusion Hypertonic saline aerosol inhalation in treatment of capillary bronchitis is better than ammonia bromine atomizing inhalation .%目的探讨雾化吸入高渗盐水和氨溴索治疗毛细支气管炎的效果。方法将60例毛细支气管炎患儿随机分为高渗盐水组(治疗组)、氨溴索组(对照1组)和常规组(对照2组),每组各20例,治疗组和对照1组在常规治疗基础上分别给雾化高渗盐水4mL或吸入氨溴索7.5mg,每8小时1次(q8h),连用1周,对照2组仅常规治疗。比较临床咳嗽、喘憋、肺部体征消失时间、住院时间等。结果60例患儿均治愈出院,治疗组疗效明显优于对照1组和对照2

  3. Clinical observation on hypertonic saline aerosol inhalation in the treatment of cap-illary bronchitis%高渗盐水雾化吸入辅助治疗毛细支气管炎的临床观察

    Institute of Scientific and Technical Information of China (English)

    黄李斐; 何樨

    2015-01-01

    Objective To discuss the treatment effect and safety of atomizing inhaled hypertonic saline for capillary bronchitis .Meth‐ods Totally 200 cases of capillary bronchitis patients were randomly divided into therapy group and control group .On the basis of conventional treatment ,the control group was provided with atomization inhaling ambroxol 15 mg dissolved in normal saline and the therapy group was provided with atomization inhaling 30 g · L -1 hypertonic saline .Comparison was made in clinical coughing , gasping suppress ,pulmonary symptoms disappearance time and hospital stay . Results The therapeutic effect of the therapy group ,with 97 .0% efficiency ,was significantly superior to the control group (82 .0% ) .There was statistical difference in wheezing disappearance ,cough disappearance ,sign disappearance and hospitalization stay .There was no harmful incident occurred during the atomization inhaling in all the patients .Conclusion The treatment effect and safety of atomizing inhaled hypertonic sa‐line for capillary bronchitis was definite ,and it was effective to relieve the clinical symptoms and shorten the hospital stays .%目的:考察高渗盐水雾化吸入辅助治疗婴幼儿毛细支气管炎的临床疗效和安全性。方法选择我院2012年1月~2014年6月收治的毛细支气管炎住院患儿200例,随机分为对照组与治疗组,在对症治疗的基础上,对照组给予氨溴索15 m g溶解于生理盐水中雾化吸入,治疗组患儿给予30g · L -1氯化钠雾化吸入,观察2组患者的临床治疗效果和安全性。结果治疗组临床总有效率为97.0%,显著高于对照组的82.0%,治疗组患儿的临床症状和体征(咳嗽气喘、哮鸣音、肺部湿罗音)消失时间和平均住院时间均显著短于对照组;且2组患儿在雾化吸入过程中均未发生不良事件。结论高渗盐水雾化吸入辅助治疗婴幼儿毛细支气管炎的效果确切,可有效缓解

  4. Effect of nursing intervention on the treatment of children with acute bronchitis in the outpatient department%护理干预对门诊急性支气管炎患儿治疗效果的影响

    Institute of Scientific and Technical Information of China (English)

    尤丽亚; 朱雪凤; 朱彩勤

    2012-01-01

    目的 探讨护理干预对门诊急性支气管炎患儿临床疗效的影响.方法 将120例急性支气管炎的门诊患儿随机分为综合护理干预组60例和对照组60例.两组均进行常规治疗与护理,干预组在此基础上进行治疗、预防、保健、认知等综合护理干预.对两组临床表现、治疗效果进行评价.结果 用药后治疗效果干预组显效率达51.67%,高于对照组33.33%;总有效率干预组为81.67%,高于对照组71.67%,差异有统计学意义(x2=4.19,P<0.05).临床表现患儿的咳嗽消失、痰鸣音消失、湿啰音消失及体温降至正常的天数干预组均少于对照组,差异有统计学意义(P<0.05).结论 护理干预对门诊急性支气管炎患儿的治疗能够增强疗效,尽快缓解患儿症状,缩短病程,提高治愈率,值得在临床推广.%Objective To investigate the effects of nursing intervention on the treatment of children with acute bronchitis in the outpatient department.Methods 120 cases of children diagnosed with acute bronchitis in the outpatient department were randomly selected and divided into intervention group and control group. Both groups received routine therapy and nursing. Intervention group was treated with nursing intervention including treatment,prevention,health care,and cognition.Clinical manifestations and treatment effects were evaluated for two groups.Results Treatment effects for the intervention group was 51.67% and significantly higher than the control group (33.33% ); The total efficacy for the intervention group is significantly higher than that for the control group (81.67% vs 71.67% respectively; x2 =4.19,P <0.05).In terms of clinical manifestations,significant more patients had disappeared coughing,Wheezy phlegm,wet rales,less days for body temperature return to normal in the intervention group than in the control group (P<0.05).Conclusions Nursing intervention for acute bronchitis pediatric outpatients

  5. Treatment effects of Tanreqing injection for acute bronchitis complicated by fever%痰热清注射液对急性支气管炎伴发热的治疗效果

    Institute of Scientific and Technical Information of China (English)

    李红燕

    2014-01-01

    Objective To investigate the application effects of Tanreqing injection for acute bronchitis complicated by fever.MethodsEighty-six patients with acute bronchitis complicated by fever admitted to our hospital from January 2012 to December 2013 were selected and divided into the control group and the observation group according to the treatment scheme. The control group received azithromycin treatment and the observation group received Tanreqing injection on the basis of the control group. The total effective rates, the disappearance time of patients' symptoms and sings and the adverse reactions during treatment of the two groups were compared. After 3 to 6 months of follow-up visits, the recurrence situation was observed.Results The total effective rate of the 43 patients of the observation group was 93.02% (40/43), which was significantly higher than that of the control group. The observation group had significantly shorter fever, cough and asthma, lung most rale disappearance and chest image recovery time than the control group. During treatment,the incidence of adverse reactions of the observation group was 2.33% (1/43), which was significantly lower than that of the control group. ConclusionIn the treatment of acute bronchitis complicated by fever, the application of Yanreqing injection can effectively improve the treatment effects, and reduce the incidence and recurrence of adverse reactions, thereby worthy of clinical promotion and application.%目的:探讨痰热清注射液在急性支气管炎伴发热中的应用效果。方法我院2012年1月~2013年12月间收治的急性支气管炎伴发热患者86例,按照治疗方案分为对照组和观察组,对照组患者给予阿奇霉素治疗,观察组在对照组基础上给予痰热清注射液,比较两组治疗总有效率、患者症状体征消失时间及治疗过程中不良反应;随访3~6个月,观察复发情况。结果观察组43例患者治疗总有效率达到93.02%(40/43

  6. 痰热清注射液规范治疗小儿急性支气管炎的效果观察%Effect observation of Tanreqing injection in the standardized treatment of acute bronchitis in children

    Institute of Scientific and Technical Information of China (English)

    刘喜梅

    2014-01-01

    目的:探讨痰热清注射液规范治疗小儿急性支气管炎的效果。方法选择本院儿科2012年1月~2013年1月收治的80例急性支气管炎患儿作为研究对象,根据随机数字表法将患者分为观察组和对照组,每组各40例。对照组给予止咳化痰、抗感染、抗病毒等常规综合方案治疗,观察组在此基础上加用痰热清注射液规范方案治疗,比较两组的临床效果。结果观察组的总有效率为97.5%,明显高于对照组的77.5%(P<0.05);观察组的退热时间、咳嗽明显减轻或消失时间均短于对照组(P<0.05)。结论在常规方案治疗的基础上,加用痰清热注射液规范治疗小儿急性支气管炎可显著提高临床效果,促使症状和体征消除,缩短病程,应用价值较为显著,对改善患儿预后,保障其身心健康有非常重要的意义。%Objective To explore the effect of Tanreqing injection in the standardized treatment of acute bronchitis in children. Methods 80 children with acute bronchitis who were admitted to the department of paediatrics in our hospital from January 2012 to January 2013 were selected as research subjects and they were divided into the observation group (n=40) and the control group (n=40) according to the random number table method.The regular and comprehensive treat-ment of relieving cough and reducing sputum,anti-infection and anti-virus were applied in the control group and a fur-ther standardized treatment of Tanreqing was added in the observation group on the basis of the control group,the clini-cal effect in the two groups was compared. Results The total effective rate in the observation group (97.5%) was signif-icantly higher than that of the control group (77.5%) (P<0.05);Fever abatement time and relieving or disappearing time of cough were both shorter than those in the control group (P<0.05). Conclusion On the basis of regular treatment,an additional standardized treatment of Tanreqing

  7. 喜炎平注射液治疗老年急性气管-支气管炎的临床研究%Clinical research on Xiyanping injection in treating elderly patients with acute airway-bronchitis

    Institute of Scientific and Technical Information of China (English)

    韩芳; 张伟东; 安学东

    2014-01-01

    OBJECTIVE To investigate the clinical results of Xiyanping injection in treating elderly patients with acute airway-bronchitis in order to improve the clinical diagnosis and treatment .METHODS Totally 70 elderly patients with acute airway-bronchitis from Feb .2010-Feb .2014 were selected and divided into two groups ,the control group of 35 patients treated with conventional symptomatic treatment ,and the observation group of 35 patients treated with addition of Xiyanping injection .The clinical effect was observed after treatment .RESULTS The effective rate and the total efficacy rate was 45 .72% and 82 .86% for the control group ,and was 62 .86% and 94 .29% for the observation group ,the difference was significant (P<0 .05) .The differences in lung function and blood gas analysis between the two groups before treatment were not significant but were significant after treatment (P< 0 .05) .The differences in improvement time for clinical manifestations were significant (P<0 .05) .CONCLUSION Xiyanping injection can improve clinical symptoms of patients with acute airway-bronchitis and shorten the course of treatment .%目的:探讨喜炎平注射液治疗老年急性气管-支气管炎临床效果,以期提高临床诊治水平。方法选取2010年2月-2014年2月70例老年急性气管-支气管炎患者为研究对象,将其分为对照组35例予常规对症治疗,观察组35例加用喜炎平注射液治疗,观察治疗后临床效果。结果对照组患者治疗显效及总有效率分别为45.72%、82.86%,观察组分别为62.86%、94.29%,两组比较差异有统计学意义( P<0.05);两组患者治疗前肺功能、血气分析比较,差异无统计学意义,而治疗后差异均有统计学意义(P<0.05);临床表现改善时间比较差异有统计学意义(P<0.05)。结论喜炎平注射液能改善急性气管-支气管炎患者临床症状,缩短疗程。

  8. 痰热清注射液治疗小儿急性支气管炎的临床疗效分析%Clinical efficacy analysis of Tanreqing injection for children acute bronchitis

    Institute of Scientific and Technical Information of China (English)

    张雷

    2011-01-01

    目的:探讨痰热清注射液治疗小儿急性支气管炎的临床效果.方法:将116例急性支气管炎随机分为治疗组和对照组各58例,对照组给予常规抗病毒、抗感染、止咳祛痰治疗,治疗组在对照组常规治疗的基础上加用痰热清注射液静脉滴注,剂量为0.5~1.0 ml/(kg·d),比较两组的治疗效果及症状改善情况.结果:治疗1周后,治疗组总有效率为96.55%(56/58),对照组总有效率为77.59%(45/58),两组疗效比较,差异有统计学意义(P<0.05);治疗组平均退热时间、咳嗽消失或明显减轻时间均短于对照组,差异有显著性(P<0.05).结论:在常规治疗的基础上应用痰热清注射液治疗小儿急性支气管炎能迅速缓解症状,缩短疗程,取得较满意的疗效.%Objective: To investigate the clinical efficacy of Tanreqing injection in the treatment of children acute bronchitis. Methods:116 patients with acute bronchitis were randomly divided into control group and treatment group, each 58 cases, the control group was given conventional antivirus, anti-infection, anti-cough expectoranting treatment, the treatment group added Tanreqing injection intravenous drip based on the control group of conventional treatment, dose for 0.5-1.0 ml/(kg·d), therapeutic effect and improvement of symptoms of two groups were compared. Results: After one week's treatment, the total effective rate of the treatment group was 96.55% (56/58), and the control group was 77.59% (45/58), compared with curative effect of the two groups, the difference had statistics significance (P<0.05). The average antifebrile time, cough disappeared or significantly reduced time of the treatment group were shorter than those of control group, there was a significant difference (P<0.05). Conclusion: the conventional treatment added Tanreqing injection in the treatment of children acute bronchitis can rapidly relieve symptoms, shorten the course of treatment, and achieve satisfactory

  9. "复方板蓝根制剂"治疗鸡传染性支气管炎的效果%Effect of Compound Chinese Medicine——Banlangen on the Treatment of Avian Infectious Bronchitis of Chicken

    Institute of Scientific and Technical Information of China (English)

    刘芳; 宋云鹏

    2009-01-01

    [目的] 观察"复方板蓝根制剂"治疗自然感染鸡传染性支气管炎的效果.[方法] 采用0.33‰、0.67‰和1.33‰ 3种不同浓度的"复方板蓝根制剂"饲喂病鸡,对7 340只自然发病鸡进行治疗,观察该药的治疗效果.[结果] 根据流行病学调查、临床症状鉴别、病理剖检变化和实验室检查确诊2个鸡场的7 340只病鸡所患疾病为鸡传染性支气管炎.病鸡服用"复方板蓝根制剂"后病情很快得到控制,未经治疗的对照组自愈率为85.18%,症状恢复缓慢;3个"复方板蓝根制剂"组的治愈率均在97%以上,病死率显著低于对照组,且症状恢复较快;0.33‰"复方板蓝根制剂"组与病毒灵组疗效相当;0.67‰和1.33‰剂量治疗组治愈率显著高于0.33‰剂量组与病毒灵治疗组.[结论] "复方板蓝根制剂"可有效治疗自然感染发病的鸡传染性支气管炎,推荐剂量为0.67‰.%[Objective] The effect of the compound Chinese medicine--Banlangen on the prevention of chicken avian infectious bronchitis naturally infected was experimented. [Method] The ill chickens were fed with the Banlangen with 3 different concentrations of 0.33 ‰, 0.67 ‰ and 1.33 ‰. The efficiency on total of 7 340 chickens treated with the method was observed. [Results] 7 340 chickens in two chicken farms were confirmed to be infected by the avian infectious bronchitis disease according to the epidemiological investigation, the identification of clinical symptoms, the pathological change in autopsy and laboratory test. The disease of treated chickens was under control soon and the recovery rate of untreated chicken(CK) was 85.18%, which recovery speed was relevant slow. The recovery rate of 3 treatments was over 97% with fast recovery speed and significantly lower rate of dead chicken than the CK. The treatment of Banlangen with 0.33 ‰ was with same efficiency as the treatment of other chemical--Bingtuling. The efficiency of the treatment of Banlangen

  10. The Chronic Responsibility

    DEFF Research Database (Denmark)

    Ravn, Iben M; Frederiksen, Kirsten; Beedholm, Kirsten

    2016-01-01

    behavior to be the main factors influencing susceptibility to chronic diseases. We argue that this discursive construction naturalizes a division between people who can actively manage responsible self-care and those who cannot. Such discourses may serve the interests of those patients who are already...

  11. Chronic fatigue syndrome.

    NARCIS (Netherlands)

    Prins, J.B.; Meer, J.W.M. van der; Bleijenberg, G.

    2006-01-01

    During the past two decades, there has been heated debate about chronic fatigue syndrome (CFS) among researchers, practitioners, and patients. Few illnesses have been discussed so extensively. The existence of the disorder has been questioned, its underlying pathophysiology debated, and an effective

  12. Chronic Myeloproliferative Neoplasms Treatment

    Science.gov (United States)

    ... Cancers by Body Location Childhood Cancers Adolescent & Young Adult Cancers Metastatic Cancer Recurrent Cancer Research NCI’s Role in ... on the hands and feet. Muscle pain. Itching. Diarrhea . Stages of Chronic Myeloproliferative Neoplasms Key Points There is no standard staging system ...

  13. CHRONIC PROBLEM FAMILIES.

    Science.gov (United States)

    STONE, EDWARD

    THE REPORT POINTS OUT THAT, IN GENERAL, CHRONIC PROBLEM PARENTS GREW UP IN ENVIRONMENTS OF EMOTIONAL IMPOVERISHMENT, INCONSISTENCY, CONFUSION, AND DISORDER, OFTEN WITH DEPRIVATION OF FOOD, CLOTHING, AND SHELTER. THESE PARENTS CATEGORIZE PEOPLE AS THOSE WHO GIVE AND THOSE WHO TAKE. THEY BLAME THEIR PROBLEMS ON EXTERNAL CIRCUMSTANCES NOT UNDER THEIR…

  14. What Is Chronic Pain?

    Medline Plus

    Full Text Available ... manageable, but chronic pain is different. And because it is different, we need to think about it in very different ways. Ed Covington, M.D.: ... no apparent physical injury or illness to explain it. The physician and the patient are accustomed to ...

  15. Efifcacy of Fuganlin oral liquid for the treatment of 58 cases of children with capillary bronchitis%馥感啉口服液治疗小儿毛细支气管炎58例

    Institute of Scientific and Technical Information of China (English)

    朱一冰; 秦晔; 严竹君; 陈逸

    2015-01-01

    目的:观察馥感啉口服液治疗小儿毛细支气管炎的疗效。方法:选取毛细支气管炎患儿112例随机分为观察组58例和对照组54例。所有患者给予抗病毒、抗感染、雾化平喘等治疗,观察组在此基础上加用馥感啉口服液治疗,比较两组疗效。结果:观察组咳嗽消失、喘憋缓解、肺部湿啰音消失、肺部哮鸣音消失的时间均短于对照组(P<0.05),治疗有效率高于对照组(P<0.05)。两组患儿在治疗期间均无明显不良反应发生。结论:馥感啉口服液治疗小儿毛细支气管炎疗效显著,安全性好。%Objective:To observe the efficacy of Fuganlin oral liquid for the treatment of children with capillary bronchitis.Methods:One hundred and twelve cases of pediatric patients were randomly divided into an observation group (n=58) and a control group (n=54). All the patients were given anti-virus, anti-infection, atomizing asthma treatment, and meanwhile, the observation group was additionally given Fuganlin oral liquid treatment. The curative effects were compared between the two groups.Results:The time for the disappearance of the cough and the moist rale and wheezing sound of the lung and the asthma suppression mitigation was shorter in the observation group than in the control group (P<0.05). The treatment effective rate of the observation group was higher than that of the control group (P<0.05). There were no obvious adverse reactions in two groups during the treatment.Conclusion:Fuganlin oral liquid has obvious efifcacy on children capillary bronchitis with good safety.

  16. Chronic Pain: Symptoms, Diagnosis, & Treatment

    Science.gov (United States)

    ... in the treatment. Treatment With chronic pain, the goal of treatment is to reduce pain and improve ... some treatments used for chronic pain. Less invasive psychotherapy, relaxation therapies, biofeedback, and behavior modification may also ...

  17. Screening for Chronic Kidney Disease

    Science.gov (United States)

    Understanding Task Force Recommendations Screening for Chronic Kidney Disease The U.S. Preventive Services Task Force (Task Force) has issued a final recommendation on Screening for Chronic Kidney Disease (CKD) . This recommendation ...

  18. Chronic Fatigue Syndrome (CFS): Symptoms

    Science.gov (United States)

    ... please visit this page: About CDC.gov . Chronic Fatigue Syndrome (CFS) Share Compartir Symptoms On this Page ... Symptoms What's the Clinical Course of CFS? Chronic fatigue syndrome can be misdiagnosed or overlooked because its ...

  19. Chinese medicine acupuncture hot Um package I, ironing acute airway-bronchitis clinical observation%中药热奄包I号穴位熨烫治疗急性气管--支气管炎的临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    王英; 杨忆; 康跃; 秦兰; 向平; 雷菲; 蒋波涛

    2015-01-01

    Objective: To investigate the thermal castrate package I, Chinese acupuncture treatment of acute airway ironing -bronchitis clinical efficacy and safety. Methods:The hospital from February 2011 to July 2013, 63 cases of acute treatment of acute airway-bronchitis were randomLy divided into traditional Chinese medicine acupuncture hot ironing Amami package I, the treatment group and the control group, the treatment group in the conventional Western medical treatment under Canadian Om package with herbal hot points I ironing treatment, the control of its clinical efficacy, assess their safety. Results: The treatment group and control group of acute acute airway-bronchitis clinical efficacy and symptom score compared to no change in two significant differences (P>0.05), in patients with cough relief time than the control group (P0.05),在患者咳嗽症状缓解时间优于对照组(P<0.05)。治疗组中药热奄包I号穴位熨烫治疗急性气管-支气管炎未见明显不良反应。结论:中药热奄包I号穴位熨烫治疗急性气管-支气管炎安全有效,可作为安全有效的中医治疗特色疗法在临床上进一步推广使用。

  20. Defining and Measuring Chronic Conditions

    Centers for Disease Control (CDC) Podcasts

    2013-05-20

    This podcast is an interview with Dr. Anand Parekh, U.S. Department of Health and Human Services Deputy Assistant Secretary for Health, and Dr. Samuel Posner, Preventing Chronic Disease Editor in Chief, about the definition and burden of multiple chronic conditions in the United States.  Created: 5/20/2013 by Preventing Chronic Disease (PCD), National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 5/20/2013.

  1. Radioaerosol lung scanning in chronic obstructive pulmonary disease (COPD) and related disorders

    International Nuclear Information System (INIS)

    As a coordinated research project of the International Atomic Energy Agency (IAEA), a multicentre joint study on radioaerosol lung scan using the BARC nebulizer has prospectively been carried out during 1988-1992 with the participation of 10 member countries in Asia [Bangladesh, China, India, Indonesia, Japan, Korea, Pakistan, Philippines, Singapore and Thailand]. The study was designed so that it would primarily cover chronic obstructive pulmonary disease (COPD) and the other related and common pulmonary diseases. The study also included normal controls and asymptomatic smokers. The purposes of this presentation are three fold: firstly, to document the usefulness of the nebulizer and the validity of user's protocol in imaging COPD and other lung diseases; secondly, to discuss scan features of the individual COPD and other disorders studied and thirdly, to correlate scan alterations with radiographic findings. Before proceeding with a systematic analysis of aerosol scan patterns in the disease groups, we documented normal pattern. The next step was the assessment of scan features in those who had been smoking for more than several years but had no symptoms or signs referable to airways. The lung diseases we analyzed included COPD [emphysema, chronic bronchitis, asthma and bronchiectasis], bronchial obstruction, compensatory overinflation and other common lung diseases such as lobar pneumonia, tuberculosis, interstitial fibrosis, diffuse panbronchiolitis, lung edema and primary and metastatic lung cancers. Lung embolism, inhalation bums and glue-sniffer's lung are separately discussed by Dr. Sundram of Singapore elsewhere in this book. The larger portion of this chapter is allocated to the discussion of COPD with a special effort made in sorting out differential scan features. Diagnostic criteria in individual COPD were defined for each category of disease and basic clinical symptoms and signs and pertinent laboratory data as well as radiographic manifestations are

  2. Lifetime environmental tobacco smoke exposure and the risk of chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Balmes John

    2005-05-01

    Full Text Available Abstract Background Exposure to environmental tobacco smoke (ETS, which contains potent respiratory irritants, may lead to chronic airway inflammation and obstruction. Although ETS exposure appears to cause asthma in children and adults, its role in causing COPD has received limited attention in epidemiologic studies. Methods Using data from a population-based sample of 2,113 U.S. adults aged 55 to 75 years, we examined the association between lifetime ETS exposure and the risk of developing COPD. Participants were recruited from all 48 contiguous U.S. states by random digit dialing. Lifetime ETS exposure was ascertained by structured telephone interview. We used a standard epidemiologic approach to define COPD based on a self-reported physician diagnosis of chronic bronchitis, emphysema, or COPD. Results Higher cumulative lifetime home and work exposure were associated with a greater risk of COPD. The highest quartile of lifetime home ETS exposure was associated with a greater risk of COPD, controlling for age, sex, race, personal smoking history, educational attainment, marital status, and occupational exposure to vapors, gas, dusts, or fumes during the longest held job (OR 1.55; 95% CI 1.09 to 2.21. The highest quartile of lifetime workplace ETS exposure was also related to a greater risk of COPD (OR 1.36; 95% CI 1.002 to 1.84. The population attributable fraction was 11% for the highest quartile of home ETS exposure and 7% for work exposure. Conclusion ETS exposure may be an important cause of COPD. Consequently, public policies aimed at preventing public smoking may reduce the burden of COPD-related death and disability, both by reducing direct smoking and ETS exposure.

  3. Chronic diseases and life events accounted for 2-18 % population attributable risks for adult hearing loss: UK Adult Psychiatric Morbidity Survey, 2007.

    Science.gov (United States)

    Shiue, Ivy

    2016-01-01

    Links between chronic diseases and hearing loss in adults have emerged. However, previous investigations were not complete, and the role of life events was unclear. Therefore, it was aimed to examine the relationships of common chronic diseases and life events and adult hearing loss in a country-wide and population-based study. Data were retrieved from UK Adult Psychiatric Morbidity Survey, 2007, being cross-sectional, including demographics, self-reported prior health conditions and hearing loss (ever and in the last 12 months), and several major life events. Analyses included Chi square test, t test, logistic regression model, and population attributable risk estimation. People who had prior health conditions including cancer, migraine, dementia, depression, cataracts, chronic bronchitis, allergy, bowel problem, bladder problem, arthritis, muscle problem or skin problem tended to report hearing loss than their counterparts. People who have experienced major life events including post-traumatic stress disorder, serious illness of close relatives, death of family, serious problems with friends, major financial crisis, valuables stolen, being bullied, violence at home, sexual abuse or running away from home were also more likely to experience ever hearing loss problem or that in the last 12 months. 2.0-13.1 % adult hearing loss could be delayed or prevented by managing chronic diseases while 4.1-18.1 % might be delayed or prevented by minimizing the negative effects of life events. Chronic diseases and life events were associated with hearing loss in adults. Better managing lifestyle to minimize detrimental impacts in future health and nursing programs would be suggested.

  4. Chronic complicated osteomyelitis

    International Nuclear Information System (INIS)

    Fourteen patients with prior trauma and/or surgery of the lower extremity and suspected active chronic osteomyelitis underwent MR imaging. Eleven patients also underwent In-111 scanning. All patients had surgical confirmation, MR imaging could assess the extent of abnormal marrow and distinguish abnormal marrow due to granulation tissue from active osteomyelitis. The presence and extent of soft-tissue infection could be determined and distinguished from bone involvement in spite of tissue distortion. The course and origin of sinus tracts could be followed. MR imaging was more sensitive to active infection than In-111 scanning. All 11 cases of active osteomyelitis were correctly diagnosed with MR imaging. In-111 scans were positive in only five of the eight cases of active infection in which scans were obtained. MR imaging is useful in chronic complicated osteomyelitis

  5. Chronic progressive multiple sclerosis

    International Nuclear Information System (INIS)

    A long-lasting immunological suppression action seems to be produced by total lymphoid irradiation; some authors emphasize the favorable effect of this treatment on chronic progressive multiple sclerosis. In order to evaluate the actual role of TLI, 6 patients affected with chronic progressive multiple sclerosis were submitted to TLI with shaped and personalized fields at the Istituto del Radio, University of Brescia, Italy. The total dose delivered was 19.8 Gy in 4 weeks, 1.8 Gy/day, 5d/w; a week elapsed between the first and the second irradiation course. Disability according to Kurtzke scale was evaluated, together with blood lymphocyte count and irradiation side-effects, over a mean follow-up period of 20.8 months (range: 13-24). Our findings indicate that: a) disease progression was not markedly reduced by TLI; b) steroid hormones responsivity was restored after irradiation, and c) side-effects were mild and tolerable

  6. [Chronic inflammatory demyelinating polyradiculoneuropathy].

    Science.gov (United States)

    Franques, J; Azulay, J-P; Pouget, J; Attarian, S

    2010-06-01

    Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a demyelinating chronic neuropathy of immune origin whose diagnosis is based upon clinical, biological and electrophysiological data; previously critical to the diagnosis the nerve biopsy is now restricted to the rare situations where accurate diagnosis cannot be reached using these data alone. CIDP are mainly idiopathic, but a few associated diseases must be sought for as they require specific attention. Such associated diseases must particularly be discussed when the manifestations are severe or resistant to immunomodulating or immunosuppressive agents. Indeed, idiopathic CIDP are usually responsive to these treatments. The effectiveness of these treatments is limited by the importance of the secondary axonal loss. The dependence or the resistance may sometimes justify the association of several immunomodulating treatments. A single randomized controlled trial support the use of cytotoxic drugs and none with rituximab.

  7. Acetaminophen for Chronic Pain

    DEFF Research Database (Denmark)

    Ennis, Zandra Nymand; Dideriksen, Dorthe; Vaegter, Henrik Bjarke;

    2016-01-01

    conducted according to PRISMA guidelines. All studies were conducted in patients with hip- or knee osteoarthritis and six out of seven studies had observation periods of less than three months. All included studies showed no or little efficacy with dubious clinical relevance. In conclusion, there is little......Acetaminophen (paracetamol) is the most commonly used analgesic worldwide and recommended as first-line treatment in all pain conditions by WHO. We performed a systematic literature review to evaluate the efficacy of acetaminophen when used for chronic pain conditions. Applying three broad search...... evidence to support the efficacy of acetaminophen treatment in patients with chronic pain conditions. Assessment of continuous efficacy in the many patients using acetaminophen worldwide is recommended. This article is protected by copyright. All rights reserved....

  8. Chronic necrotizing pulmonary aspergillosis

    Directory of Open Access Journals (Sweden)

    Lovrenski Aleksandra

    2011-01-01

    Full Text Available Introduction. Chronic necrotizing pulmonary aspergillosis (CNPA is a cavitary, infectious process of lung parenchyma with slow progressive course. Vascular invasion and dissemination to other organs are unusual. Case report. We presented a 25-year old man with bilineal acute leukaemia who developed pulmonary and systemic symptoms. Chest CT showed nodular consolidations and cavitary lesions in both lungs. Bronchial biopsy revealed necrotic hyphae but it was negative for Aspergillus by culture. Serum was positive for antibodies to Aspergillus, but it was negative for antigens. A thoracoscopic lung biopsy of the upper left lobe revealed necrosis of lung tissue, with acute and chronic inflammation of the cavity wall and the presence of hyphae consistent with Aspergillus species. Conclusion. Although confirmation of the diagnosis is difficult, a combination of characteristic clinical, radiological and histological findings and either serological results positive for Aspergillus or the isolation of Aspergillus from respiratory samples are highly indicative of CNPA.

  9. Molecular epidemiology of the avian infectious bronchitis virus basing on S1 glycoprotein%基于S1蛋白的禽传染性支气管炎病毒的分子流行病学研究

    Institute of Scientific and Technical Information of China (English)

    姜明国; 杨立芳

    2005-01-01

    Avian infectious bronchitis virus, a kind of ssRNA positive- strand virus which belongs to Coronaviridae without any DNA stage, is one of the most severe pathogenic agent causing acute, highly contagious respiratory and urogenital disease characterized by high mortality rate in affected avian flocks, resulting in gigantic economic loss every year. Thereby, it is urgent and necessary for us to research the molecular epidemiology of avian infectious bronchitis virus, and even develop vaccines basing above basic research results. Here we report the molecular evolution and genetic variation of the avian infectious bronchitis virus basing the conserved nucleotide acid sequence of S1gene encoding the spiker glycoprotein with the strong feature ofthe antigen immunity, locating on the surface of the avian infectious bronchitis virus particle, and provide the feasible strategy to develop the avian vaccine for effectively perturbing the infection of avian infectious bronchitis virus.%禽传染性支气管炎病毒是归属于冠状病毒属的没有DNA阶段的正义单链RNA病毒,以极高的死亡率引起禽呼吸泌尿性疾病的广泛流行,每年都给家禽饲养业造成巨大的经济损失.因此开展禽传染性支气管炎病毒的分子流行病学的研究并开发出相关的疫苗时下就显得迫切而且必要.现在,我们基于序列保守且具有强免疫原性的禽传染性支气管炎病毒粒子外壳剌突S1糖蛋白开展了分子流行病学研究,并提出了用于阻断禽传染性支气管炎病毒侵染的疫苗的可行性开发策略.

  10. 内蒙中西部地区婴幼儿毛细支气管炎发病与血清IgA.C3浓度相关性探讨%ongolia Midwest infant capillary bronchitis disease and serum IgA.C3 concentration correlation is discussed

    Institute of Scientific and Technical Information of China (English)

    赵宇静

    2013-01-01

    Objective To explore the Inner Mongolia Midwest infant capillary bronchitis causes relates to the concentration of serum IgA ,C зchildren.Method For 1-2 years old children,134 cases of capillary bronchitis and at the same time on the hospital 1-2 years old and 100 cases children with bronchial pneumonia and.50 cases of normal control group,the application of turbidimetric method determination of peripheral blood serum IgA ,Cзconcentration,and comparative analysis.Results of capillary bronchitis group serum IgA,C зconcentration is the same with the normal group,no obvious changes,the feeling and bronchial pneumonia group of serum IgA, C зconcentration determination value compared to normal children changes.Conclusion in the same exposure,infection factors on sense and bronchial pneumonia group of serum IgA,C зconcentration change,capillary bronchitis group of serum IgA,C зconcentration change no difference,capillary bronchitis risk factors not sure,need to be researched.%目的:探讨内蒙中西部地区婴幼儿毛细支气管炎发病原因与患儿血清IgA、Cз浓度关系。方法对1-2岁毛细支气管炎患儿134例及同期入院1-2岁上感及支气管肺炎患儿100例,正常对照组50例,应用比浊法测定外周血血清 IgA、Cз浓度,并进行对比分析。结果毛细支气管炎组血清IgA、Cз浓度与正常组相同,无明显变化,上感及支气管肺炎组血清IgA、Cз浓度对比正常儿童测定值变化大。结论在相同感染因素暴露下,上感及支气管肺炎组血清IgA、Cз浓度改变,毛细支气管炎组血清IgA、Cз浓度变化无差异,提示毛细支气管炎患儿免疫功能异常,发病原因有待继续研究。

  11. Diagnosis, Prevention and Treatment of Glandular Stomachk Type Infectious Bronchitis Complicated with Colibacillosis%鸡腺胃型传染性支气管炎继发大肠杆菌病的诊断与防治

    Institute of Scientific and Technical Information of China (English)

    汪德生; 王文亮; 彭晓军

    2011-01-01

    某养殖场饲养的麻黄鸡(882)发生以拉黄绿色稀粪、咳嗽、伸颈张口呼吸、腺胃显著肿大等为特征的病例。通过对送检病死鸡详细解剖病变观察和实验室诊断,结果表明,造成本次疫病发生的主要原因是腺胃型传染性支气管炎病毒感染继发大肠杆菌病。%A group of Mahuang chickens(g82) from a brooding farm appeared the symptoms of yellow- green dilute manure, cough, dyspnea and proventricular significant enlargement. Finally, the chicken were diagnosised as avian proventricular type infectious bronchitis and escherichia coli secondary infection by pathological anatomy and a series of laboratory diagnosis.

  12. Two novel neutralizing antigenic epitopes of the s1 subunit protein of a QX-like avian infectious bronchitis virus strain Sczy3 as revealed using a phage display peptide library.

    Science.gov (United States)

    Zou, Nianli; Xia, Jing; Wang, Fuyan; Duan, Zhenzhen; Miao, Dan; Yan, Qigui; Cao, Sanjie; Wen, Xintian; Liu, Ping; Huang, Yong

    2015-11-15

    The spike (S) protein of the infectious bronchitis virus (IBV) plays a central role in the pathogenicity, the immune antibody production, serotype and the tissue tropism. In this study, we generate 11 monoclonal antibodies (mAbs) against S1 subunit of IBV Sczy3 strain, and two mAbs 1D5 and 6A12 were positive in indirect ELISA against both His-S1 protein and the purified whole viral antigen. MAb 6A12 and 1D5 could recognized by other 10 IBV strains (IBVs) from five different genotypes, except that 1D5 had a relatively low reaction with two of the 10 tested IBVs. End-point neutralizing assay performed in chicken embro kidney (CEK) cells revealed that the neutralization titer of 6A12 and 1D5 against Sczy3 reached 1:44.7 and 1:40.6, respectively. After screening a phage display peptide library and peptide scanning, we identified two linear B-cell epitopes that were recognized by the mAbs 1D5 and 6A12, which corresponded to the amino acid sequences (87)PPQGMAW(93) and (412)IQTRTEP(418), respectively, in the IBV S1 subunit. Sequences comparison revealed that epitope (412)IQTRTEP(418) was conserved among IBVs, while the epitope (87)PPQGMAW(93) was relatively variable among IBVs. The novel mAbs and the epitopes identified will be useful for developing diagnostic assays for IBV infections.

  13. Chronic cough in children.

    Science.gov (United States)

    Wagner, Johana B Castro; Pine, Harold S

    2013-08-01

    The management of chronic cough, a common complaint in children, is challenging for most health care professionals. Millions of dollars are spent every year on unnecessary testing and treatment. A rational approach based on a detailed interview and a thorough physical examination guides further intervention and management. Inexpensive and simple homemade syrups based on dark honey have proved to be an effective measure when dealing with cough in children. PMID:23905830

  14. Chronic Cough in Childhood

    OpenAIRE

    Alexander, David S.

    1982-01-01

    Persistent cough in children is a symptom, and the cause should be ascertained. Reactive airways disease is the most common reason for chronic cough in children over three to six months of age, especially at night. Under three months, the cause is likely to be more serious. Cough often disturbs parents more than the child, and physicians should consider parents' need for sleep and relief when deciding whether or not to prescribe cough suppressants. Investigations depend on the child's age, th...

  15. Chronic inflammatory systemic diseases

    OpenAIRE

    Straub, Rainer H.; Schradin, Carsten

    2016-01-01

    It has been recognized that during chronic inflammatory systemic diseases (CIDs) maladaptations of the immune, nervous, endocrine and reproductive system occur. Maladaptation leads to disease sequelae in CIDs. The ultimate reason of disease sequelae in CIDs remained unclear because clinicians do not consider bodily energy trade-offs and evolutionary medicine. We review the evolution of physiological supersystems, fitness consequences of genes involved in CIDs during different life-history sta...

  16. Chronic pneumonitis of infancy

    Energy Technology Data Exchange (ETDEWEB)

    Abe, Katsumi; Kamata, Noriko; Okazaki, Eiwa [Department of Radiology, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8677 (Japan); Moriyama, Sachiko; Funata, Nobuaki [Department of Pathology, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8677 (Japan); Takita, Junko; Yamada, Hideo; Takayama, Naohide [Department of Pediatrics, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8677 (Japan)

    2002-07-01

    Chronic pneumonitis of infancy (CPI) is a very rare lung disease in infants and young children. We report a 33-day-old infant with CPI, focusing on the radiologic aspects of the disease. Chest radiographs showed variable and non-specific appearances including ground-glass shadowing, consolidation, volume loss, and hyperinflation. Dense alveolar opacities progressed as CPI advanced. The radiologic features of our case reflected pathologic changes. (orig.)

  17. Renal failure (chronic)

    OpenAIRE

    Clase, Catherine

    2009-01-01

    Chronic renal failure is characterised by a gradual and sustained decline in renal clearance or glomerular filtration rate (GFR). Continued progression of renal failure will lead to renal function too low to sustain healthy life. In developed countries, such people will be offered renal replacement therapy in the form of dialysis or renal transplantation. Requirement for dialysis or transplantation is termed end-stage renal disease (ESRD).Diabetes, glomerulonephritis, hypertension, pyelone...

  18. Chronic alloantibody mediated rejection

    OpenAIRE

    Smith, R. Neal; Colvin, Robert B.

    2011-01-01

    Alloantibodies clearly cause acute antibody mediated rejection, and all available evidence supports their pathogenic etiology in the development of chronic alloantibody mediated rejection (CAMR). But the slow evolution of this disease, the on-going immunosuppression, the variations in titer of alloantibodies, and variation in antigenic targets all complicate identifying which dynamic factors are most important clinically and pathologically. This review highlights the pathological factors rela...

  19. Approaching chronic cough

    OpenAIRE

    Poulose, Vijo; Tiew, Pei Yee; How, Choon How

    2016-01-01

    Chronic cough is one of the most common reasons for referral to a respiratory physician. Although fatal complications are rare, it may cause considerable distress in the patient’s daily life. Western and local data shows that in patients with a normal chest radiograph, the most common causes are postnasal drip syndrome, postinfectious cough, gastro-oesophageal reflux disease and cough variant asthma. Less common causes are the use of angiotensin-converting enzyme inhibitors, smoker’s cough an...

  20. Chronic obstructive pulmonary disease.

    Science.gov (United States)

    Barnes, Peter J; Burney, Peter G J; Silverman, Edwin K; Celli, Bartolome R; Vestbo, Jørgen; Wedzicha, Jadwiga A; Wouters, Emiel F M

    2015-01-01

    Chronic obstructive pulmonary disease (COPD) is a common disease with high global morbidity and mortality. COPD is characterized by poorly reversible airway obstruction, which is confirmed by spirometry, and includes obstruction of the small airways (chronic obstructive bronchiolitis) and emphysema, which lead to air trapping and shortness of breath in response to physical exertion. The most common risk factor for the development of COPD is cigarette smoking, but other environmental factors, such as exposure to indoor air pollutants - especially in developing countries - might influence COPD risk. Not all smokers develop COPD and the reasons for disease susceptibility in these individuals have not been fully elucidated. Although the mechanisms underlying COPD remain poorly understood, the disease is associated with chronic inflammation that is usually corticosteroid resistant. In addition, COPD involves accelerated ageing of the lungs and an abnormal repair mechanism that might be driven by oxidative stress. Acute exacerbations, which are mainly triggered by viral or bacterial infections, are important as they are linked to a poor prognosis. The mainstay of the management of stable disease is the use of inhaled long-acting bronchodilators, whereas corticosteroids are beneficial primarily in patients who have coexisting features of asthma, such as eosinophilic inflammation and more reversibility of airway obstruction. Apart from smoking cessation, no treatments reduce disease progression. More research is needed to better understand disease mechanisms and to develop new treatments that reduce disease activity and progression. PMID:27189863

  1. Imaging of chronic osteomyelitis

    International Nuclear Information System (INIS)

    The diagnosis of chronic osteomyelitis is made on the basis of clinical, radiologic and histologic findings. The role of imaging in patients with known chronic osteomyelitis is to detect and to delineate areas of active infection. To correctly interpret the imaging findings, it is essential to take both the individual clinical findings and previous imaging studies into account. Reliable signs of active infection are bone marrow abscess, sequestra and sinus tract formation. Only the combined evaluation of bony changes together with alterations of the adjacent soft tissues provides good diagnostic accuracy. Projection radiography gives an overview of the condition of the bone, which provides the basis for follow-up and the selection of further imaging modalities. Computed tomography can be used to evaluate even discrete or complex bony alterations and to guide percutaneous biopsy or drainage. Magnetic resonance imaging achieves the best diagnostic sensitivity and specificity and provides superior contrast as well as anatomical resolution in both bone marrow and soft tissues. In this paper the features and clinical relevance of imaging in primary chronic osteomyelitis, posttraumatic osteomyelitis, tuberculous spondylitis and osteomyelitis of the diabetic foot are reviewed, with particular respect to MRI. (orig.)

  2. Chronic arsenic poisoning.

    Science.gov (United States)

    Hall, Alan H

    2002-03-10

    Symptomatic arsenic poisoning is not often seen in occupational exposure settings. Attempted homicide and deliberate long-term poisoning have resulted in chronic toxicity. Skin pigmentation changes, palmar and plantar hyperkeratoses, gastrointestinal symptoms, anemia, and liver disease are common. Noncirrhotic portal hypertension with bleeding esophageal varices, splenomegaly, and hypersplenism may occur. A metallic taste, gastrointestinal disturbances, and Mee's lines may be seen. Bone marrow depression is common. 'Blackfoot disease' has been associated with arsenic-contaminated drinking water in Taiwan; Raynaud's phenomenon and acrocyanosis also may occur. Large numbers of persons in areas of India, Pakistan, and several other countries have been chronically poisoned from naturally occurring arsenic in ground water. Toxic delirium and encephalopathy can be present. CCA-treated wood (chromated copper arsenate) is not a health risk unless burned in fireplaces or woodstoves. Peripheral neuropathy may also occur. Workplace exposure or chronic ingestion of arsenic-contaminated water or arsenical medications is associated with development of skin, lung, and other cancers. Treatment may incklude the use of chelating agents such as dimercaprol (BAL), dimercaptosuccinic acid (DMSA), and dimercaptopanesulfonic acid (DMPS).

  3. Volumetric capnography for the evaluation of chronic airways diseases

    Directory of Open Access Journals (Sweden)

    Veronez L

    2014-09-01

    Full Text Available Liliani de Fátima Veronez,1 Monica Corso Pereira,2 Silvia Maria Doria da Silva,2 Luisa Affi Barcaui,2 Eduardo Mello De Capitani,2 Marcos Mello Moreira,2 Ilma Aparecida Paschoalz2 1Department of Physical Therapy, University of Votuporanga (Educational Foundation of Votuporanga, Votuporanga, 2Department of Internal Medicine, School of Medical Sciences, State University of Campinas (UNICAMP, Campinas, Sao Paulo, BrazilBackground: Obstructive lung diseases of different etiologies present with progressive peripheral airway involvement. The peripheral airways, known as the silent lung zone, are not adequately evaluated with conventional function tests. The principle of gas washout has been used to detect pulmonary ventilation inhomogeneity and to estimate the location of the underlying disease process. Volumetric capnography (VC analyzes the pattern of CO2 elimination as a function of expired volume.Objective: To measure normalized phase 3 slopes with VC in patients with non-cystic fibrosis bronchiectasis (NCB and in bronchitic patients with chronic obstructive pulmonary disease (COPD in order to compare the slopes obtained for the groups.Methods: NCB and severe COPD were enrolled sequentially from an outpatient clinic (Hospital of the State University of Campinas. A control group was established for the NCB group, paired by sex and age. All subjects performed spirometry, VC, and the 6-Minute Walk Test (6MWT. Two comparisons were made: NCB group versus its control group, and NCB group versus COPD group. The project was approved by the ethical committee of the institution. Statistical tests used were Wilcoxon or Student’s t-test; P<0.05 was considered to be a statistically significant difference.Results: Concerning the NCB group (N=20 versus the control group (N=20, significant differences were found in body mass index and in several functional variables (spirometric, VC, 6MWT with worse results observed in the NCB group. In the comparison between

  4. Mortality rates for chronic lower respiratory diseases in Italy from 1979 to 2010: an age–period–cohort analysis

    Directory of Open Access Journals (Sweden)

    Giancarlo Pesce

    2016-03-01

    Full Text Available Chronic lower respiratory diseases (CLRDs are a major cause of morbidity and mortality worldwide. The objectives of this study were to estimate the trends in CLRD mortality in Italy, and the specific contributions of age, time period and birth cohort in driving these trends. Population and cause-of-death data in Italy between 1979 and 2010 were collected from the World Health Organization website. Age-specific mortality rates for CLRDs, and effects for age, time period and birth cohort on mortality trends were estimated using age–period–cohort models. Chronic obstructive pulmonary disease (COPD and chronic bronchitis represent nearly 98% of the deaths from CLRDs. Despite the overall number of deaths have been stable (in men or increasing (in women, the age-standardised rates have been steadily decreasing from 1979 to 2010, passing from 104.3 to 55.4 per 100 000 person-years in men and from 32.2 to 19.6 per 100 000 person-years in women. The average relative annual decrease was −3.6% in men and −2.7% in women. Since the end of the 1990s, the decreasing trend of CLRD mortality has started to level off, in particular in women. The decrease in CLRD mortality rates has been more accentuated in more recent cohorts and in younger age groups. Both birth cohort and time period significantly affected the CLRD mortality rates, suggesting that changes in the spread of risk factors (smoking habits, early-life and occupational exposures across different birth cohorts, as well as in advanced in healthcare and medical practice, may have played a major role in secular changes in COPD mortality rates in Italy.

  5. Corticosteroids in the treatment of acute exacerbations of chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Woods JA

    2014-05-01

    Full Text Available J Andrew Woods,1 James S Wheeler,1 Christopher K Finch,2 Nathan A Pinner3 1School of Pharmacy, Wingate University, Wingate, NC, USA; 2Department of Pharmacy, Methodist University Hospital, Memphis, TN, USA; 3Harrison School of Pharmacy, Auburn University, Auburn, AL, USA Background: Chronic obstructive pulmonary disease (COPD is a chronic and progressive disease that affects an estimated 10% of the world's population over the age of 40 years. Worldwide, COPD ranks in the top ten for causes of disability and death. Given the significant impact of this disease, it is important to note that acute exacerbations of COPD (AECOPD are by far the most costly and devastating aspect of disease management. Systemic steroids have long been a standard for the treatment of AECOPD; however, the optimal strategy for dosing and administration of these medications continues to be debated. Objective: To review the use of corticosteroids in the treatment of acute exacerbations of COPD. Materials and methods: Literature was identified through PubMed Medline (1950–February 2014 and Embase (1950–February 2014 utilizing the search terms corticosteroids, COPD, chronic bronchitis, emphysema, and exacerbation. All reference citations from identified publications were reviewed for possible inclusion. All identified randomized, placebo-controlled trials, meta-analyses, and systematic reviews evaluating the efficacy of systemic corticosteroids in the treatment of AECOPD were reviewed and summarized. Results: The administration of corticosteroids in the treatment of AECOPD was assessed. In comparison to placebo, systemic corticosteroids improve airflow, decrease the rate of treatment failure and risk of relapse, and may improve symptoms and decrease the length of hospital stay. Therefore, corticosteroids are recommended by all major guidelines in the treatment of AECOPD. Existing literature suggests that low-dose oral corticosteroids are as efficacious as high

  6. History of Chronic Subdural Hematoma.

    Science.gov (United States)

    Lee, Kyeong-Seok

    2015-10-01

    Trephination or trepanation is an intentional surgical procedure performed from the Stone Age. It looks like escaping a black evil from the head. This technique is still used for treatment of chronic subdural hematoma (SDH). Now, we know the origin, pathogenesis and natural history of this lesion. The author try to explore the history of trephination and modern discovery of chronic SDH. The author performed a detailed electronic search of PubMed. By the key word of chronic SDH, 2,593 articles were found without language restriction in May 2015. The author reviewed the fact and way, discovering the present knowledge on the chronic SDH. The first authentic report of chronic SDH was that of Wepfer in 1657. Chronic SDH was regarded as a stroke in 17th century. It was changed as an inflammatory disease in 19th century by Virchow, and became a traumatic lesion in 20th century. However, trauma is not necessary in many cases of chronic SDHs. The more important prerequisite is sufficient potential subdural space, degeneration of the brain. Modifying Virchow's description, chronic SDH is sometimes traumatic, but most often caused by severe degeneration of the brain. From Wepfer's first description, nearly 350 years passed to explore the origin, pathogenesis, and fate of chronic SDH. The nature of the black evil in the head of the Stone Age is uncovering by many authors riding the giant's shoulder. Chronic SDH should be categorized as a degenerative lesion instead of a traumatic lesion. PMID:27169062

  7. Chronic radiation syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Akleyev, Alexander V. [Urals Research Centre for Radiation Medicine, Chelyabinsk (Russian Federation). Clinical Dept.

    2014-04-01

    Comprehensive analysis of chronic radiation syndrome, covering epidemiology, pathogenesis, pathoanatomy, diagnosis and treatment. Based on observations in a unique sample of exposed residents of the Techa riverside villages in the Urals. Casts new light on the condition. Of value for all practitioners and researchers with an interest in chronic radiation syndrome. This book covers all aspects of chronic radiation syndrome (CRS) based on observations in a unique sample of residents of the Techa riverside villages in the southern Urals who were exposed to radioactive contamination in the 1950s owing to releases of liquid radioactive wastes from Mayak Production Association, which produced plutonium for weapons. In total, 940 cases of CRS were diagnosed in this population and these patients were subjected to detailed analysis. The opening chapters address the definition and classification of CRS, epidemiology and pathogenesis, covering molecular and cellular mechanisms, radioadaptation, and the role of tissue reactions. The pathoanatomy of CRS during the development and recovery stages is discussed for all organ systems. Clinical manifestations of CRS at the different stages are then described in detail and the dynamics of hematopoietic changes are thoroughly examined. In the following chapters, principles of diagnosis (including assessment of the exposure doses to critical organs) and differential diagnosis from a wide range of other conditions are discussed and current and potential treatment options, described. The medical and social rehabilitation of persons with CRS is also covered. This book, which casts new light on the condition, will be of value for all practitioners and researchers with an interest in CRS.

  8. Refractory chronic cluster headache

    DEFF Research Database (Denmark)

    Mitsikostas, Dimos D; Edvinsson, Lars; Jensen, Rigmor H;

    2014-01-01

    for clinical and research use. The preparation of the final consensus followed three stages. Internal between authors, a larger between all European Headache Federation members and finally an international one among all investigators that have published clinical studies on cluster headache the last five years......Chronic cluster headache (CCH) often resists to prophylactic pharmaceutical treatments resulting in patients' life damage. In this rare but pragmatic situation escalation to invasive management is needed but framing criteria are lacking. We aimed to reach a consensus for refractory CCH definition...

  9. Chronic granulomatous disease

    Directory of Open Access Journals (Sweden)

    Nair Pradeep

    2005-01-01

    Full Text Available A 2½-year-old child presented with multiple discrete granulomatous lesions on the face and flexural regions since the age of 2 months along with lymphadenopathy. The patient also had recurrent bouts of pyodermas and respiratory tract infections. Biopsy of the lesion showed necrosis of tissue with suppuration and histiocytes but no evidence of tuberculosis, fungal infections or atypical mycobacteria. Lymph node biopsy also showed necrosis with suppuration but no infective organism. Nitroblue tetrazolium test was negative indicating that the neutrophils failed to oxidize the dye. We are reporting here a rare case of chronic granulomatous disease.

  10. Pathogenesis of chronic urticaria.

    Science.gov (United States)

    Kaplan, A P; Greaves, M

    2009-06-01

    Chronic urticaria is defined as the presence of urticaria (hives) for at least 6 weeks with the assumption that it occurs daily or close to it. If we eliminate physical urticarias and urticarial vasculitis from consideration, the remainder can be divided into autoimmune chronic urticaria (45%) and idiopathic chronic urticaria (55%). The autoimmune subgroup is associated with the IgG anti-IgE receptor alpha subunit in 35-40% of patients and IgG anti-IgE in an additional 5-10%. These autoantibodies have been shown to activate blood basophils and cutaneous mast cells in vitro with augmentation of basophil activation by complement and release of C5a, in particular. Binding methods (immunoblot and ELISA) yield positives in many autoimmune diseases as well as occasional normal subjects or patients with other forms of urticaria but most such sera are non-functional. Activation of basophils or mast cells causing histamine release is quite specific for chronic urticaria and defines the autoimmune subgroup. Although pathogenicity is not formally proven, the antibodies cause wealing upon intradermal injection, and removal of the autoantibody leads to remission. A cellular infiltrate is seen to be characterized by mast cell degranulation and infiltration of CD4+ T lymphocytes, monocytes, neutrophils, eosinophils, and basophils. The intensity of the infiltrate and clinical severity of the disease (including accompanying angio-oedema) is more severe in the autoimmune subpopulation. This latter group also has a higher evidence of human leucocyte antigen DR alleles associated with autoimmunity and a 25% incidence of antithyroid antibodies with diagnosed hypothyroidism in some. Hypo-responsiveness of patients' basophils to anti-IgE and hyperresponsiveness to serum defines another subpopulation (at least 50%) that overlaps the idiopathic and autoimmune subgroups. Hypo-responsiveness to anti-IgE has been shown to be associated with elevated levels of cytoplasmic phosphatases that

  11. Sexuality and chronic illness.

    Science.gov (United States)

    Steinke, Elaine E

    2013-11-01

    Sexual function is often affected in individuals living with chronic illness and their partners, and multiple comorbidities increase the likelihood of sexual dysfunction. This review focuses on the areas of cardiovascular disease, respiratory conditions, and cancer, all areas for which there are practical, evidence-based strategies to guide sexual counseling. Although nurses have been reluctant to address the topic of sexuality in practice, a growing number of studies suggest that patients want nurses to address their concerns and provide resources to them. Thus, nurses must be proactive in initiating conversations on sexual issues to fill this gap in practice. PMID:24066783

  12. Chronic inflammatory demyelinative polyneuropathy

    DEFF Research Database (Denmark)

    Said, Gérard; Krarup, Christian

    2013-01-01

    Chronic inflammatory demyelinative polyneuropathy (CIDP) is an acquired polyneuropathy presumably of immunological origin. It is characterized by a progressive or a relapsing course with predominant motor deficit. The diagnosis rests on the association of non-length-dependent predominantly motor...... deficit following a progressive or a relapsing course associated with increased CSF protein content. The demonstration of asymmetrical demyelinating features on nerve conduction studies is needed for diagnosis. The outcome depends on the amplitude of axon loss associated with demyelination. CIDP must...... be differentiated from acquired demyelinative neuropathies associated with monoclonal gammopathies. CIDP responds well to treatment with corticosteroids, intravenous immunoglobulins, and plasma exchanges, at least initially....

  13. [Chronic nonbacterial osteomyelitis].

    Science.gov (United States)

    Keskitalo, Paula; Remes-Pakarinen, Terhi; Vähäsalo, Paula; Niinimäki, Jaakko; Kröger, Liisa

    2016-01-01

    Chronic nonbacterial osteomyelitis is an autoinflammatory disease occurring mainly in children and adolescents, typically involving recurrent or persistent osteitic foci. The symptom is bone pain, possibly accompanied by soft tissue tenderness. Some patients exhibit symptoms of systemic inflammation. The. precise etiology of the disease is not known, but an imbalance of inflammatory and anti-inflammatory cytokines is presumed to play a role in the development of the disease. While an anti-inflammatory analgesic is in most cases sufficient to calm down the osteitis, the use of corticosteroids, anti- TNF-a inhibitors or bisphosphonates is required in some cases. PMID:26939487

  14. Chronic granulomatous disease.

    Science.gov (United States)

    Nair, Pradeep S; Moorthy, Prasanna K; Suprakasan, S; Jayapalan, Sabeena; Preethi, K

    2005-01-01

    A 2(1/2)-year-old child presented with multiple discrete granulomatous lesions on the face and flexural regions since the age of 2 months along with lymphadenopathy. The patient also had recurrent bouts of pyodermas and respiratory tract infections. Biopsy of the lesion showed necrosis of tissue with suppuration and histiocytes but no evidence of tuberculosis, fungal infections or atypical mycobacteria. Lymph node biopsy also showed necrosis with suppuration but no infective organism. Nitroblue tetrazolium test was negative indicating that the neutrophils failed to oxidize the dye. We are reporting here a rare case of chronic granulomatous disease. PMID:16394414

  15. Breath sounds

    Science.gov (United States)

    Causes of abnormal breath sounds may include: Acute bronchitis Asthma Bronchiectasis Chronic bronchitis Congestive heart failure Emphysema Interstitial lung disease Foreign body obstruction of the airway Pneumonia Pulmonary edema Tracheobronchitis

  16. Pulmonary function tests

    Science.gov (United States)

    ... of lung disease, such as asthma , bronchitis , and emphysema Find the cause of shortness of breath Measure ... or lung disease. Some lung diseases (such as emphysema, asthma, chronic bronchitis, and infections) can make the ...

  17. Breathing difficulties - first aid

    Science.gov (United States)

    ... health conditions that may cause breathing problems are: Anemia (low red blood cell count) Asthma Chronic obstructive pulmonary disease (COPD), sometimes called emphysema or chronic bronchitis Heart ...

  18. Chronic effects of air pollution on respiratory health in Southern California children: findings from the Southern California Children's Health Study.

    Science.gov (United States)

    Chen, Zhanghua; Salam, Muhammad T; Eckel, Sandrah P; Breton, Carrie V; Gilliland, Frank D

    2015-01-01

    Outdoor air pollution is one of the leading contributors to adverse respiratory health outcomes in urban areas around the world. Children are highly sensitive to the adverse effects of air pollution due to their rapidly growing lungs, incomplete immune and metabolic functions, patterns of ventilation and high levels of outdoor activity. The Children's Health Study (CHS) is a continuing series of longitudinal studies that first began in 1993 and has focused on demonstrating the chronic impacts of air pollution on respiratory illnesses from early childhood through adolescence. A large body of evidence from the CHS has documented that exposures to both regional ambient air and traffic-related pollutants are associated with increased asthma prevalence, new-onset asthma, risk of bronchitis and wheezing, deficits of lung function growth, and airway inflammation. These associations may be modulated by key genes involved in oxidative-nitrosative stress pathways via gene-environment interactions. Despite successful efforts to reduce pollution over the past 40 years, air pollution at the current levels still brings many challenges to public health. To further ameliorate adverse health effects attributable to air pollution, many more toxic pollutants may require regulation and control of motor vehicle emissions and other combustion sources may need to be strengthened. Individual interventions based on personal susceptibility may be needed to protect children's health while control measures are being implemented.

  19. Late and chronic Lyme disease.

    Science.gov (United States)

    Donta, Sam T

    2002-03-01

    This article reviews the late and chronic manifestations of Lyme disease. Special attention is given to the chronic manifestations of the disease, detailing its pathogenesis, clinical spectrum, and laboratory criteria for the diagnosis. Based on experimental evidence and experience, approaches to the successful treatment of the late and chronic disease are outlined. Much additional work is needed to improve the understanding of the underlying pathophysiology of the disease, its diagnosis and treatment.

  20. Hyperphosphatemia of Chronic Kidney Disease

    OpenAIRE

    Hruska, Keith A.; Mathew, Suresh; Lund, Richard; Qiu, Ping; Pratt, Raymond

    2008-01-01

    Observational studies have determined hyperphosphatemia to be a cardiovascular risk factor in chronic kidney disease. Mechanistic studies have elucidated that hyperphosphatemia is a direct stimulus to vascular calcification, which is one cause of morbid cardiovascular events contributing to the excess mortality of chronic kidney disease. This review describes the pathobiology of hyperphosphatemia that develops as a consequence of positive phosphate balance in chronic kidney disease and the me...

  1. [Psychosomatic approach for chronic migraine].

    Science.gov (United States)

    Hashizume, Masahiro

    2011-11-01

    From psychosomatic view point, the psychological or social stresses and depressive or anxiety disorders are very important factors in the course and the maintenance for migraine patients. These factors are very complex, and often lead the migraine becoming chronic. In the psychosomatic approach, not only the physical assessment for chronic migraine but also the assessments for stress and mental states are done. As the psychosomatic therapies for chronic migraine, autogenic training, biofeedback therapy and cognitive therapy are effective. PMID:22277516

  2. Chronic urticaria: new management options

    OpenAIRE

    Greenberger, Paul A.

    2014-01-01

    Chronic urticaria is defined as episodic or daily hives lasting for at least 6 weeks and impairs quality of life. Two main subtypes include chronic idiopathic (spontaneous) urticaria and inducible (physical) urticaria, but some patients have urticarial vasculitis. “Autoimmune chronic urticaria” implies the presence of histamine releasing or mast cell activating autoantibodies to IgE or FcϵRI, the high affinity receptor on mast cells and basophils. In patients not readily controlled with label...

  3. Chronic wound management and research

    OpenAIRE

    Romanelli M

    2014-01-01

    Marco Romanelli Wound Healing Research Unit, Division of Dermatology, University of Pisa, Pisa, ItalyI would like to share with you a new open access peer-reviewed journal – Chronic Wound Care Management and Research, published by Dove Medical Press. Chronic Wound Care Management and Research is an international, peer-reviewed, open-access online journal publishing original research, case reports, reviews, editorials, and commentaries on the management of chronic wounds and...

  4. Obstructive Jaundice in Chronic Pancreatitis

    OpenAIRE

    Hollands, M. J.; Little, J. M.

    1989-01-01

    Significant obstructive jaundice in chronic pancreatitis is generally considered to be rare. Eleven of 57 consecutive patients with proven chronic pancreatitis have developed significant obstructive jaundice of more than transient duration. Eight presented as jaundice complicating known pancreatitis and three as jaundice of unknown cause. Life table analysis showed a steady rise in the risk of developing jaundice up to the end of 10 years from the onset of chronic pancreatitis. Jaundice was f...

  5. Diagnostic dilemmas in chronic urticaria.

    Science.gov (United States)

    Toubi, E; Grattan, C; Zuberbier, T

    2015-06-01

    The European Academy of Allergy and Clinical Immunology (EAACI)/Global Allergy and Asthma European Network (GA(2) LEN)/European Dermatology Forum (EDF)/World Allergy Organization (WAO) recently published updated recommendations for the classification, diagnosis and management of chronic urticaria (CU). This article discusses several cases of CU that provide examples of how the recommendations in the guidelines can be implemented in the diagnosis of chronic spontaneous urticaria (CSU) (also called chronic idiopathic urticaria [CIU]), chronic inducible urticaria (CINDU) or CU with comorbidities.

  6. Idiopathic chronic eosinophilic pneumonia

    Directory of Open Access Journals (Sweden)

    Cordier Jean-François

    2006-04-01

    Full Text Available Abstract Idiopathic chronic eosinophilic pneumonia (ICEP is characterized by subacute or chronic respiratory and general symptoms, alveolar and/or blood eosinophilia, and peripheral pulmonary infiltrates on chest imaging. Eosinophilia is present in most cases, usually in excess of 1000/mm3. In absence of significant blood eosinophilia, a diagnosis of ICEP is supported by the demonstration of bronchoalveolar lavage eosinophilia. ICEP is typically associated with eosinophil counts higher than lymphocyte counts in the bronchoalveolar lavage. ICEP is a rare disorder of unknown cause. Its exact prevalence remains unknown. ICEP may affect every age group but is rare in childhood. It is twice as frequent in women as in men. One third to one half of the ICEP patients have a history of asthma. The mainstay of treatment of ICEP is systemic corticosteroids. Response to oral corticosteroid therapy is dramatic and has led to the consideration of corticosteroid challenge as a diagnostic test for ICEP. Nevertheless, relapses or development of severe asthma are frequent when tapering or withdrawing treatment. Long-term oral corticosteroid therapy is necessary in up to half of the patients.

  7. The chronic leukaemias

    Directory of Open Access Journals (Sweden)

    Peter Jacobs

    1989-09-01

    Full Text Available The slow progression of both chronic granulocytic and lymphocytic leukaemia, when compared to their acute counterparts, has been used as an argument to support less aggressive therapy or even, in some instances, a watch-and-wait policy. This conservative approach is bolstered by a number of observations including the ease with which haematologic control can initially be achieved, the older age of patients with the lymphocytic variant and the paucity of controlled data showing that long disease-free survival or cure can result from the use of aggressive treatment. Given these circumstances, it is not surprising that many such individuals are managed outside specialised centres using a variety of agents and schedules, both of which may, on occasions, be inappropriate. Accumulating evidence suggests a need to reconsider these practices since cure is now possible in selected patients with chronic granulocytic leukaemia while the use of multi-drug regimens in the lymphatic form can significantly improve survival. These advances are the result of carefully conducted clinical trials involving many individuals the world over and constitute the basis fo r advocating early referral to those institutions where all the necessary expertise is available.

  8. Chronic Hepatitis C.

    Science.gov (United States)

    Tran, Tram T.; Martin, Paul

    2001-12-01

    Infection with hepatitis C virus (HCV) accounts for 40% of cases of chronic liver disease in the United States and is now the most common indication for liver transplantation. Estimates suggest that 4 million people (1.8%) of the American population are or have been infected with HCV. Currently, the treatment of choice for patients with chronic HCV infection is recombinant interferon alfa with ribavirin. Pegylated interferons are a promising new development, and in combination with ribavirin, they will rapidly become the standard of care. The goals of therapy are to slow disease progression, improve hepatic histology, reduce infectivity, and reduce the risk of hepatocellular carcinoma. Sustained virologic response, which generally implies the absence of viremia for 6 months or more following completion of therapy, is increasingly being regarded as a cure, with evidence of slowing or even regression of fibrosis on follow-up liver biopsy. A number of factors have been shown to be predictive of a sustained response, including viral genotype other than 1, low serum HCV RNA levels, absence of cirrhosis, younger age, female gender, and shorter duration of infection. Disease severity as assessed by liver biopsy, comorbidities, and possible contraindications to therapy should be weighed in the decision to begin treatment. Counseling patients regarding transmission, natural history, and drug and alcohol abstinence also should be included in management. Close monitoring should be done during treatment for side effects of interferon, including depression and bone marrow suppression. Hemolytic anemia is the major side effect of ribavirin. PMID:11696276

  9. Refractory chronic migraine

    DEFF Research Database (Denmark)

    Martelletti, Paolo; Katsarava, Zaza; Lampl, Christian;

    2014-01-01

    The debate on the clinical definition of refractory Chronic Migraine (rCM) is still far to be concluded. The importance to create a clinical framing of these rCM patients resides in the complete disability they show, in the high risk of serious adverse events from acute and preventative drugs and...... of these patients, the correct application of innovative therapeutic techniques and lastly aim to be acknowledged as clinical entity in the next definitive version of the International Classification of Headache Disorders 3 (ICHD-3 beta).......The debate on the clinical definition of refractory Chronic Migraine (rCM) is still far to be concluded. The importance to create a clinical framing of these rCM patients resides in the complete disability they show, in the high risk of serious adverse events from acute and preventative drugs...... and in the uncontrolled application of therapeutic techniques not yet validated.The European Headache Federation Expert Group on rCM presents hereby the updated definition criteria for this harmful subset of headache disorders. This attempt wants to be the first impulse towards the correct identification...

  10. Primary diagnosis and therapy tests of nephropathogenic avian infectious bronchitis%鸡肾型传染性支气管炎的初步诊断与治疗

    Institute of Scientific and Technical Information of China (English)

    李瑞明; 史玉静; 韩涛; 韩忠燕; 宋小白

    2011-01-01

    [Objective ]The present study was conducted to investigate the epidemiology of avian infectious bronchitis (IB) in Qinhuangdao city of Hebei province, and to isolate the local representative strain of IB virus for development of immuo-vaccine. [Method]The epidemiology investigation, clinical manifestations and pathological changes in IB were recorded. The liver and kidney suspension of freshly sampled chicken were inoculated to ten--day SPF chick embryo allantoic cavity and the chicken embryo allantois solution was collected to conduct agar diffuse, haemagglutination (HA) and animal test. The comprehensive therapy was also practiced. [ Result ]The kidney of inoculated chick showed swelling and was found pale colored. White urate deposition in ureter was observed. The agar diffuse test result of allantois liquid showed positive results, as well as the HA and animal test results revealed that the isolated strain was IB virus. Based on pathological diagnosis, the lB was identified as nephropathgenic lB. The inactivated vaccine was made with isolated strains of nephropathogenic infectious bronchitis viruses. After 5 days of treatment with Hukang, Shenzhishuang, Hushentong and other medicines, the mortality of diseased chicken was recorded from 0.4 to 1.0%, the symptom in respiratory tract of chicken population decreased and the eggs production increased. The curative rate of lB in chicken reached 92.4%. [Conclustion ]The results of present study confirmed the disease as nephropathgenic lB. The proper medication and and immunization according to the virus strain can prevent the disease.%[目的]研究河北秦皇岛地区的鸡肾型鸡传染性支气管炎(IB)流行病学、分离鉴定地方代表毒株,为有效防制当地鸡肾型IB及研制具有免疫针对性的疫苗制剂提供参考依据.[方法]通过流行病学调查、临床症状、病理变化观察,取新鲜病死雏鸡肝脏、肾脏组织悬浮液接种10日龄SPF鸡胚尿囊腔,收集鸡胚尿

  11. 小儿喘息性支气管炎雾化吸入治疗的护理措施%Discussion of care measures in children with asthmatic bronchitis inhalation therapy

    Institute of Scientific and Technical Information of China (English)

    李红; 李艳

    2015-01-01

    Objective:To understand the clinical effect of children with asthmatic bronchitis inhalation therapy care measures. Methods:100 patients with application in the treatment of inhalation asthmatic bronchitis were selected from 2011 to 2014. According to the nursing program they were divided into the control group and the observation group,50 cases in each group.The control group were received routine treatment and nursing,and the observation group accepted for treatment and nursing of atomizing inhalation.The two groups were compared for the clinical efficacy.Results:The observation group with clinical treatment of the total efficiency of 92%,significantly better than the control group the total efficiency of 78%,and there was statistically significant(P<0.05).The observation group with parents on the satisfaction degree of nursing intervention to the control group was significant superiority,and there was statistically significant(P<0.05).Conclusion:The main clinical treatment of children with asthmatic bronchial is inhalation.Nursing intervention measures detailed in the course of treatment can guarantee the better therapeutic effects,the greatest extent to reduce the impact of disease on the life quality of patients.It is worthy of clinical popularization and promotion.%目的:了解雾化吸入治疗喘息性支气管炎小儿患儿的护理措施及其临床价值。方法:2011年-2014年收治应用雾化吸入方案治疗喘息性支气管炎患儿100例,根据护理方案将其分为对照组与观察组,每组50例。对照组接受常规治疗护理,观察组接受针对性雾化吸入治疗护理。对比两组患儿临床治疗效果。结果:观察组临床治疗总有效率92.0%,显著优于对照组总有效率78.0%,差异有统计学意义(P<0.05);观察组患儿家长对护理干预满意程度相对于对照组患儿家长有显著优越性,差异有统计学意义(P<0.05)。结论:对喘息性支气管患儿主要临床

  12. Clinical Scenarios in Chronic Kidney Disease: Chronic Tubulointerstitial Diseases.

    Science.gov (United States)

    Meola, Mario; Samoni, Sara; Petrucci, Ilaria

    2016-01-01

    Chronic tubulointerstitial diseases are a common final pathway toward chronic renal failure regardless the primary damage (glomerular, vascular or directly the tubulointerstitium). Chronic tubulointerstitial nephritis (CTN) is characterized by interstitial scarring, fibrosis and tubule atrophy, resulting in progressive chronic kidney disease. Most frequent causes of CTN are drugs, heavy metals, obstructive uropathy, nephrolithiasis, reflux disease, immunologic diseases, neoplasia, ischemia, metabolic diseases, genetics and miscellaneous. At ultrasound (US), kidneys' morphological aspect is similar in all forms of chronic interstitial nephropathy and only chronic pyelonephritis with or without reflux shows distinguishing characteristics. In interstitial nephropathy, kidneys' profiles are finely irregular and corticomedullary differentiation is altered because of a diffused hyperechogenicity. The only indirect sign of chronic interstitial damage can be derived from the value of intrarenal resistive indexes that hardly overcome 0.75. US is mandatory in clinical chronic pyelonephritis work-up because it provides information on kidney's diameter and on growth nomogram in children. Renal profiles can be more or less altered depending on the number of cortical scars and the presence of pseudonodular areas of segmental compensatory hypertrophy. In the early stages, US diagnosis of renal tuberculosis is difficult because parenchymal lesions are non-specific. US sensitivity in the diagnosis of hydronephrosis is very high, close to 100% and, finally, US is the first choice imaging technique in the diagnosis of urinary lithiasis. PMID:27169608

  13. Molecular genetics of chronic neutrophilic leukemia, chronic myelomonocytic leukemia and atypical chronic myeloid leukemia

    OpenAIRE

    Li, Bing; Gale, Robert Peter; Xiao, Zhijian

    2014-01-01

    According to the 2008 World Health Organization classification, chronic neutrophilic leukemia, chronic myelomonocytic leukemia and atypical chronic myeloid leukemia are rare diseases. The remarkable progress in our understanding of the molecular genetics of myeloproliferative neoplasms and myelodysplastic/myeloproliferative neoplasms has made it clear that there are some specific genetic abnormalities in these 3 rare diseases. At the same time, there is considerable overlap among these disord...

  14. A STUDY TO EVALUATE THE ROLE OF ELECTROCARDIOGRAPHIC CHANGES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

    Directory of Open Access Journals (Sweden)

    Jagadeesh

    2015-02-01

    were males. For diagnosis of COPD, guidelines by American Thoracic Society 1 and also by British Thoracic Society 2 were followed. COPD included chronic bronchitis and emphysema cases, but asthma was excluded, as airflow obstruction is largely reversible in this condition. Some other ch ronic lung diseases were also excluded. To assess diagnostic values of ECG, a control group of patients who attended OPD for respiratory problems other than COPD was also considered. Other respiratory diseases like pulmonary tuberculosis, non - tubercular pu lmonary infections, pleural disease, malignancy etc ., were diagnosed by adopting their respective diagnostic criteria available along with clinical judgment . Information of socio - demographic characteristics like age, sex, religion, socioeconomic status (SE S, social background, occupation and smoking habits was collected. Study subjects were classified according to spectrum of respiratory diseases. Patients underwent different clinical and radiological investigations. Further evaluation was also done by ECG . A 12 lead ECG including 3 bipolar limb leads, 3 unipolar limb leads and 6 unipolar precordial leads was performed. All necessary precautions desired in ECG were observed. ECG was done by single channel BPL card art various108T/MK - V I machine. Various ECG parameters like rate, axis deviation, P - wave changes, QRS complex, T - wave, ST changes etc. were observed. The axis of P - value and QRS complex was calculated by hex axial reference system. The study was approved by Institutional research committee and all ethical guidelines of Helsinki 3 were followed. RESULTS AND CONCLUSION: A total 100 patient of COPD were studied, out of which there were 30 females and 70 males. Respirat ory problems were more common among rural males of low socio - economic group. COPD particularly chronic bronchitis was the commonest respiratory problem next to pulmonary tuberculosis. In spite of normal heart rate observed in 71.4% COPD patients

  15. Folate Deficiency in Chronic Pancreatitis

    Directory of Open Access Journals (Sweden)

    Gopalakrishna Rajesh

    2010-07-01

    Full Text Available Dear Sir, While there has been a spurt of interest in genetic alterations associated with pancreatitis in the past few years, interest in the role of environmental factors has largely focused on alcoholism and smoking with insufficient attention being paid to the contributions of nutritional deficiency, and the role of environmental toxins in the pathogenesis of pancreatitis. Braganza and Dormandy [1] argue convincingly about the role played by cytochrome P450 monooxygenases (especially CYP1A enzyme induction by xenobiotics and the resultant oxidative stress, as also the now increasingly recognized reductive stress posed by the metabolites in initiating pancreatic injury. Their article underlines the important part played by the deficiency of methyl and thiol molecules in different stages of the progression of pancreatic damage. Furthermore, they attempt to establish a link between environmental and genetic factors and bring in a holistic view on the etiopathogenesis of chronic pancreatitis. We have recently demonstrated lower plasma methionine levels in two cohorts of chronic pancreatitis patients; one of tropical chronic pancreatitis and the other, of alcoholic chronic pancreatitis as compared to healthy controls [2] which suggests that deficiency of methyl groups may be a factor in various forms of pancreatitis. Similarly, we have shown lower red cell glutathione levels in chronic pancreatitis patients with tropical chronic pancreatitis and alcoholic chronic pancreatitis, indicating deficiency of thiol molecules. In addition, we have demonstrated significantly higher levels of plasma total homocysteine in chronic pancreatitis patients than in healthy controls. Moreover, our study has shown that there is a deficiency of red cell folate in the majority of chronic pancreatitis patients, more so in tropical chronic pancreatitis; and that folate deficiency appeared to be the key factor in hyperhomocysteinemia in chronic pancreatitis patients

  16. Chronic diseases and mental disorder.

    NARCIS (Netherlands)

    Verhaak, P.F.M.; Heijmans, M.J.W.M.; Peters, L.; Rijken, M.

    2005-01-01

    The aim of this study was to achieve a better understanding of the relationship between chronic medical illness and mental distress. Therefore, the association between chronic medical illness and mental distress was analysed, taking into account the modifying effects of generic disease characteristi

  17. Pharmacologic Agents for Chronic Diarrhea

    OpenAIRE

    Lee, Kwang Jae

    2015-01-01

    Chronic diarrhea is usually associated with a number of non-infectious causes. When definitive treatment is unavailable, symptomatic drug therapy is indicated. Pharmacologic agents for chronic diarrhea include loperamide, 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists, diosmectite, cholestyramine, probiotics, antispasmodics, rifaximin, and anti-inflammatory agents. Loperamide, a synthetic opiate agonist, decreases peristaltic activity and inhibits secretion, resulting in the reductio...

  18. Chronic sleep reduction in adolescents

    OpenAIRE

    Dewald-Kaufmann, J.F.

    2012-01-01

    Based on the results of this thesis, it can be concluded that sleep problems and chronic sleep reduction have a high impact on adolescents’ daytime functioning. Additionally, this research shows that gradual sleep extension can improve adolescents’ sleep and especially their chronic sleep reduction. This approach has beneficial effects on adolescents’ depressive symptoms and their cognitive performance.

  19. Chronic Kidney Disease and Medicines

    Science.gov (United States)

    ... from our online catalog. Alternate Language URL Español Chronic Kidney Disease and Medicines: What You Need to Know Page ... What you need to know Because you have chronic kidney disease, you should take steps to protect your kidneys. ...

  20. Program for the Chronically Ill.

    Science.gov (United States)

    Schoenherr, Arline; Schnarr, Barbara

    The program for chronically ill students in the Detroit public schools is described. Forms are presented listing needed information and implications for teachers of the following conditions: diabetes, sickle cell anemia, chronic renal failure, congenital heart disease, hemophilia, rheumatoid arthritis, asthma, leukemia, and cystic fibrosis. The…

  1. Chronic hypophosphatemic osteopathy

    Energy Technology Data Exchange (ETDEWEB)

    Koppers, B.; Schmid, L.; Hofmann, E.; Sauer, E.

    1980-07-01

    The process of chronic hypophosphatemic vitamine D-resistant rickets is described by observation of two cases. With the male patient - our first case - the disease was sporadic and had not been recognized for a long time. In his early adulthood it manifested itself as Umbauzonen (pseudofractures) in the larger context of active osteomalacia. It was possible to observe the pseudofractures before and while the patient was medicamentously treated. High doses of vitamine D 3 and dosage of phosphate mitigated the complaints although with respect to the radiological, scintigraphical, humoral and histological findings there was only slow improvement or no improvement at all. The patient's daughter is affected by the disease as well. In her case the pathological signs of her bones became better when treated with vitamine D 3.

  2. [Treatment of chronic polyarthritis].

    Science.gov (United States)

    Frey, D; Hasler, P; Tyndall, A

    1997-11-15

    Rheumatoid arthritis (RA) is a chronic autoimmune disease involving progressive destruction of multiple joints and, in the later stages, significant mortality. Worldwide, 1% of the population is afflicted. Despite new insights into the autoimmune mechanisms during the last decade a cure has not been found, although pain, disability and general suffering can be alleviated via several therapeutic approaches when carefully coordinated. Early use of immunosuppressive therapy with DMARDs (disease modifying antirheumatic drugs), while avoiding their side effects, is critical for disease control. Counselling within a good doctor-patient relationship, with the additional help of physiotherapy and ergotherapy, increases the patient's capacity to cope with the disease. Hand and joint surgery, skillfully performed, decreases pain and disability. Newer strategies of immunosuppression, while encouragingly effective, are only short term. These experimental agents are more expensive, they are associated with side effects and their future place in RA therapy has yet to be defined. PMID:9454312

  3. 小儿支气管炎急性发作应用阿奇霉素的临床治疗效果观察%Observation on the Clinical Effect of Azithromycin in the Treatment of Children With Acute Bronchitis

    Institute of Scientific and Technical Information of China (English)

    李海涛

    2015-01-01

    目的:分析研究小儿支气管炎急性发作通过阿奇霉素进行治疗的方法以及治疗效果,为临床提供依据。方法选取2013年3月~2014年3月小儿支气管炎急性发作患者资料88例实施回顾性分析。结果观察组患者治疗效果高于对照组患者,不良反应发生几率低于对照组患者(P <0.05),具有统计学意义。结论针对小儿支气管炎急性发作通过阿奇霉素进行治疗效果明显,患者出现不良反应几率小,属于一类安全有效的抗菌药物。%Objective To analyze and study the methods and therapeutic effect of the treatment of acute bronchitis acute attack of children, and provide the basis for clinical treatment. Methods A retrospective analysis was carried out on 88 cases of acute exacerbation of children's bronchitis from March 2013 to March 2014. Results The therapeutic effect of the observation group was significantly higher than that of the control group, the incidence of adverse reactions was significantly lower than that of the control group (P < 0.05), with statistical significance. Conclusion In the treatment of children with acute bronchitis acute attack by the effect of treatment, patients with small adverse reactions, is a kind of safe and effective antibacterial drugs.

  4. 'Chronic' identities in mental illness.

    Science.gov (United States)

    von Peter, Sebastian

    2013-04-01

    The term 'chronicity' is still widely used in psychiatric discourse and practice. A category employed in political, administrative and therapeutic contexts, it guides practitioners' beliefs and actions. This paper attempts a review of the attitudes and procedures that result as a consequence of identifying 'chronically' disturbed identities in clinical practice. An essentially social, relational and materialist understanding of mental illness is used to highlight the kind of thinking underlying the notion of 'chronic' identities in day-to-day psychiatric routines. Problematising the notions of singularity and expressiveness, as well as mind/body- and self/other-distinctions, it claims the category itself is responsible for creating a 'chronic' kind of being. A spatial metaphor is presented in the conclusion, illustrating a mental strategy by which we can re-shape our thinking about 'chronic' identities. It attempts to describe how the shift from an epistemological to a praxeographic approach could build a more complete understanding of mental illness. PMID:23528064

  5. Understanding anemia of chronic disease.

    Science.gov (United States)

    Fraenkel, Paula G

    2015-01-01

    The anemia of chronic disease is an old disease concept, but contemporary research in the role of proinflammatory cytokines and iron biology has shed new light on the pathophysiology of the condition. Recent epidemiologic studies have connected the anemia of chronic disease with critical illness, obesity, aging, and kidney failure, as well as with the well-established associations of cancer, chronic infection, and autoimmune disease. Functional iron deficiency, mediated principally by the interaction of interleukin-6, the iron regulatory hormone hepcidin, and the iron exporter ferroportin, is a major contributor to the anemia of chronic disease. Although anemia is associated with adverse outcomes, experimental models suggest that iron sequestration is desirable in the setting of severe infection. Experimental therapeutic approaches targeting interleukin-6 or the ferroportin-hepcidin axis have shown efficacy in reversing anemia in either animal models or human patients, although these agents have not yet been approved for the treatment of the anemia of chronic disease.

  6. Chronic Cough in Adults (Beyond the Basics)

    Science.gov (United States)

    ... of Use ©2016 UpToDate, Inc. Patient education: Chronic cough in adults (Beyond the Basics) Authors Ronald C ... and helps to prevent infection. However, sometimes a cough can become a chronic condition. A chronic cough ...

  7. Treatment Options by Stage (Chronic Lymphocytic Leukemia)

    Science.gov (United States)

    ... ALL Treatment Childhood AML Treatment Research Chronic Lymphocytic Leukemia Treatment (PDQ®)–Patient Version General Information About Chronic Lymphocytic Leukemia Go to Health Professional Version Key Points Chronic ...

  8. Treatment Option Overview (Chronic Lymphocytic Leukemia)

    Science.gov (United States)

    ... ALL Treatment Childhood AML Treatment Research Chronic Lymphocytic Leukemia Treatment (PDQ®)–Patient Version General Information About Chronic Lymphocytic Leukemia Go to Health Professional Version Key Points Chronic ...

  9. Treatment Options for Chronic Myelogenous Leukemia

    Science.gov (United States)

    ... ALL Treatment Childhood AML Treatment Research Chronic Myelogenous Leukemia Treatment (PDQ®)–Patient Version General Information About Chronic Myelogenous Leukemia Go to Health Professional Version Key Points Chronic ...

  10. General Information about Chronic Myelogenous Leukemia

    Science.gov (United States)

    ... ALL Treatment Childhood AML Treatment Research Chronic Myelogenous Leukemia Treatment (PDQ®)–Patient Version General Information About Chronic Myelogenous Leukemia Go to Health Professional Version Key Points Chronic ...

  11. Treatment Option Overview (Chronic Myelogenous Leukemia)

    Science.gov (United States)

    ... ALL Treatment Childhood AML Treatment Research Chronic Myelogenous Leukemia Treatment (PDQ®)–Patient Version General Information About Chronic Myelogenous Leukemia Go to Health Professional Version Key Points Chronic ...

  12. Integration of healthcare rehabilitation in chronic conditions

    DEFF Research Database (Denmark)

    Frølich, Anne; Høst, Dorte; Schnor, Helle;

    2010-01-01

    of rehabilitation programmes in four conditions. DESCRIPTION OF CARE PRACTICE: FOUR MULTIDISCIPLINARY REHABILITATION INTERVENTION PROGRAMMES, ONE FOR EACH CHRONIC CONDITION: chronic obstructive pulmonary disease, type 2 diabetes, chronic heart failure, and falls in elderly people were developed and implemented...... during the project period. The chronic care model was used as a framework for support of implementing and integration of the four rehabilitation programmes. CONCLUSION AND DISCUSSION: The chronic care model provided support for implementing rehabilitation programmes for four chronic conditions...

  13. Update on the pathological processes, molecular biology, and clinical utility of N-acetylcysteine in chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Tse HN

    2014-08-01

    Full Text Available Hoi Nam Tse, Cee Zhung Steven TsengMedical and Geriatric Department, Kwong Wah Hospital, Hong Kong Special Administrative RegionAbstract: Chronic obstructive pulmonary disease (COPD is a common and morbid disease characterized by high oxidative stress. Its pathogenesis is complex, and involves excessive oxidative stress (redox imbalance, protease/antiprotease imbalance, inflammation, apoptosis, and autoimmunity. Among these, oxidative stress has a pivotal role in the pathogenesis of COPD by initiating and mediating various redox-sensitive signal transduction pathways and gene expression. The protective physiological mechanisms of the redox balance in the human body, their role in the pathogenesis of COPD, and the clinical correlation between oxidative stress and COPD are reviewed in this paper. N-acetylcysteine (NAC is a mucolytic agent with both antioxidant and anti-inflammatory properties. This paper also reviews the use of NAC in patients with COPD, especially the dose-dependent properties of NAC, eg, its effects on lung function and the exacerbation rate in patients with the disease. Earlier data from BRONCUS (the Bronchitis Randomized on NAC Cost-Utility Study did not suggest that NAC was beneficial in patients with COPD, only indicating that it reduced exacerbation in an "inhaled steroid-naïve" subgroup. With regard to the dose-dependent properties of NAC, two recent randomized controlled Chinese trials suggested that high-dose NAC (1,200 mg daily can reduce exacerbations in patients with COPD, especially in those with an earlier (moderately severe stage of disease, and also in those who are at high risk of exacerbations. However, there was no significant effect on symptoms or quality of life in patients receiving NAC. Further studies are warranted to investigate the effect of NAC at higher doses in non-Chinese patients with COPD.Keywords: N-acetylcysteine, antioxidant, anti-inflammatory, chronic obstructive pulmonary disease

  14. Indoor air pollution from solid fuel use, chronic lung diseases and lung cancer in Harbin, Northeast China

    Energy Technology Data Exchange (ETDEWEB)

    Galeone, C.; Pelucchi, C.; La Vecchia, C.; Negri, E.; Bosetti, C.; Hu, J.F. [Ist. ric. farmacologiche Mario Negri, Milan (Italy)

    2008-10-15

    In some areas of China, indoor air pollution (IAP) originating principally from the combustion of solid fuels has a relevant role in lung cancer. Most previous studies focused on the female population and only a few on both the sexes. We analyzed the relationship between IAP from solid fuel use and selected chronic lung diseases and lung cancer risk in Harbin, Northeast China, an area with a very high base line risk of lung cancer for both the sexes. We used data from a case-control study conducted between 1987 and 1990, including 218 patients with incident, histologically confirmed lung cancer and 436 controls admitted to the same hospitals as cases. We calculated an index of IAP from solid fuel use exposure using data on heating type, cooking fuel used, and house measurements. Cases reported more frequently than controls on exposure to coal fuel for house heating and/or cooking, and the odds ratio (OR) for ever versus never exposed was 2.19 (95% confidence interval (CI): 1.08-4.46). The ORs of lung cancer according to subsequent tertiles of IAP exposure index were 1.82 (95% CI: 1.14-2.89) and 1.99 (95% CI: 1.26-3.15) as compared with the lowest tertile. The ORs of lung cancer for participants with a history of chronic bronchitis and tuberculosis were 3.79 (95% CI: 2.38-6.02) and 3.82 (95% CI: 1.97-7.41), respectively. This study gives further support and quantification of the positive association between IAP, history of selected nonmalignant lung diseases, and lung cancer risk for both the sexes.

  15. The hydrotherapy in the treatment of patients with Chronic Obstructive Pulmonary Disease - doi:10.5020/18061230.2007.p221

    Directory of Open Access Journals (Sweden)

    Fernanda Gadelha Severino

    2012-01-01

    Full Text Available The Chronic Obstructive Pulmonary Disease (COPD is a serious, disabling disease, presenting the pulmonary function test with abnormalities in the expiratory flow. Under this denomination, it comprises the chronic bronchitis and pulmonary emphysema. The hydrotherapy involves the physical therapy with aquatic exercises and has being used because it is a pleasant activity with positive results. The aim of this exploratory study was to compare the performance of the patients with COPD treated with hydrotherapy associated to pulmonary rehabilitation with those treated only with pulmonary rehabilitation, being held in the cardiopulmonary rehabilitation center of Messejana Hospital, in Fortaleza - Ceará. The sample consisted of 10 patients, independently of sex and age, randomly divided into two groups. The evaluation instrument was the upper limbs incremental test observing the following parameters: the cardiac frequency (FC, the respiratory frequency (f, the degree of dyspnea, the tiredness of the upper limbs, the maximum burden reached and the oxygen saturation (SatO2. The parameters FC (p=0.04, f (p=0.046 e SatO2 (p=0.008 presented an average improvement of 33.33% above those of the patients that were just in the pulmonary rehabilitation. The other evaluated parameters also presented positive results, but with p>0.05. In conclusion, the results obtained with the pulmonary rehabilitation associated to the hydrotherapy overcome those found just with the pulmonary rehabilitation treatment, allowing an increase in the physical conditioning and improvement in the functional activities; although, due to the reduced number of cases, new researches should be held to confirm this exploratory study.

  16. EBV CHRONIC INFECTIONS

    Directory of Open Access Journals (Sweden)

    Delia Racciatti

    2010-02-01

    Full Text Available

    The infection from Epstein-Barr virus (EBV or virus of infectious mononucleosis, together with other herpesviruses’ infections, represents a prototype of persistent viral infections characterized by the property of the latency. Although the reactivations of the latent infection are associated with the resumption of the viral replication and eventually with the “shedding”, it is still not clear if this virus can determine chronic infectious diseases, more or less evolutive. These diseases could include some pathological conditions actually defined as “idiopathic”and characterized by the “viral persistence” as the more credible pathogenetic factor. Among the so-called idiopathic syndromes, the “chronic fatigue syndrome” (CFS aroused a great interest around the eighties of the last century when, just for its relationship with EBV, it was called “chronic mononucleosis” or “chronic EBV infection”.

    Today CFS, as defined in 1994 by the CDC of Atlanta (USA, really represents a multifactorial syndrome characterized by a chronic course, where reactivation and remission phases

  17. [Mnemonic complaints and chronic migraine].

    Science.gov (United States)

    Santos-Lasaosa, S; Viloria-Alebesque, A; Morandeira-Rivas, C; Lopez Del Val, L J; Bellosta-Diago, E; Velazquez-Benito, A

    2013-08-16

    INTRODUCTION. Patients with chronic migraine often report lower cognitive performance, which affects their quality of life. AIMS. To analyse whether the mnemonic capacity of patients with chronic migraine is altered or not. SUBJECTS AND METHODS. A cross-sectional study was conducted in patients with chronic migraine evaluated consecutively in our unit, and paired by age (18-60 years) and gender with a control group consisting of cognitively healthy volunteers. The following cognitive instruments were administered: Folstein Minimental State Examination (MMSE), Memory Alteration Test (M@T), Montreal Cognitive Assessment (MoCA) and working memory. RESULTS. A total of 30 patients with chronic migraine were included (mean age: 49.33 ± 10.05 years) paired with a control group of 30 healthy volunteers (mean age: 44.83 ± 10.91 years). The mean elapsed time since onset of the patients with chronic migraine was 4.47 ± 2.74 years. On performing a comparative analysis between the two groups, significant differences were found with overall lower scores in the group of patients with chronic migraine in the MoCA (24.16 versus 29), M@T (43.76 versus 48.8) and working memory tests (17.5 versus 24.26). Performance in the MMSE was similar in both groups. CONCLUSIONS. Patients with chronic migraine can have lower cognitive performance regardless of distracting elements, such as pharmacological factors or psychiatric comorbidity, since chronic migraine can be understood as yet another element within the spectrum of chronic pain. PMID:23884868

  18. Chronic Thromboembolic Pulmonary Hypertension Associated with Chronic Inflammation.

    Science.gov (United States)

    Kuse, Naoyuki; Abe, Shinji; Kuribayashi, Hidehiko; Fukuda, Asami; Kusunoki, Yuji; Narato, Ritsuko; Saito, Hitoshi; Gemma, Akihiko

    2016-01-01

    Chronic thromboembolic pulmonary hypertension (CTEPH) is one of the leading causes of severe pulmonary hypertension. According to previously reported studies in the pertinent literature, chronic inflammatory conditions may be implicated in the development of CTEPH. We herein describe the case of a 56-year-old woman who was diagnosed with CTEPH in association with chronic infection. The patient had experienced five episodes of pneumonia in the five years prior to the diagnosis of CTEPH. Blood tests from the previous five years of outpatient follow-up demonstrated that the C-reactive protein level was slightly elevated. This case suggests that a relationship exists between chronic inflammation and CTEPH, and furthermore, may contribute towards elucidating the pathophysiology of CTEPH. PMID:27250055

  19. Chronic paronychia in a hairdresser.

    Science.gov (United States)

    Allouni, A; Yousif, A; Akhtar, S

    2014-09-01

    Chronic paronychia is a common occupational disease. It is multifactorial and affects a number of different groups of workers. However, the condition is not described as affecting hairdressers although hairdressing is associated with a range of other occupation-related hand conditions. We report an unusual case of chronic paronychia in a female hairdresser which occurred as a consequence of a hair shaft penetrating beneath the nail fold. Personal hygiene with thorough removal of any hairs that have penetrated the epidermis and wearing clean gloves can prevent the condition. We suggest that clinicians should be aware of the types of occupation and mechanisms involved in patients developing chronic paronychia. PMID:24985481

  20. Autoimmunity in chronic lymphocytic leukaemia.

    Science.gov (United States)

    Lischner, M; Prokocimer, M; Zolberg, A; Shaklai, M

    1988-08-01

    Seventy-nine patients with chronic lymphocytic leukaemia were evaluated for the presence of autoimmune diseases and autoantibodies. One patient has polymyositis and two additional patients presented with features suggestive of pernicious anaemia and chronic active hepatitis. The Coombs' direct test was positive in 7% and immune thrombocytopenia was present in 8.1% of patients. Five (7%) patients had M-protein in the serum. No increased frequency of other autoantibodies was noted in our study group. We conclude that the propensity to develop antibodies is restricted only to the haematopoietic system and that there is no increased frequency of non-haematological autoimmune diseases in chronic lymphatic leukaemia. PMID:3249703