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Sample records for bronchitis chronic

  1. Chronic Bronchitis

    Science.gov (United States)

    Bronchitis is an inflammation of the bronchial tubes, the airways that carry air to your lungs. It ... chest tightness. There are two main types of bronchitis: acute and chronic. Chronic bronchitis is one type ...

  2. Living with Chronic Bronchitis

    Science.gov (United States)

    ... from the NHLBI on Twitter. Living With Chronic Bronchitis If you have chronic bronchitis, you can take steps to control your symptoms. ... and a pneumonia vaccine. If you have chronic bronchitis, you may benefit from pulmonary rehabilitation (PR). PR ...

  3. Heredity of chronic bronchitis

    DEFF Research Database (Denmark)

    Meteran, Howraman; Backer, Vibeke; Kyvik, Kirsten Ohm; Skytthe, Axel; Thomsen, Simon Francis

    2014-01-01

    BACKGROUND: Smoking is a major risk factor for lung diseases and lower respiratory symptoms, but since not all smokers develop chronic bronchitis and since chronic bronchitis is also diagnosed in never-smokers, it has been suggested that some individuals are more susceptible to develop chronic...... bronchitis due to genetics. OBJECTIVE: To study the relative influence of genetic and environmental factors on the variation in the susceptibility to chronic bronchitis. METHODS: In a population-based questionnaire study of 13,649 twins, 50-71 years of age, from the Danish Twin Registry, we calculated sex......-specific concordance rates and heritability of chronic bronchitis. The response rate was 75%. RESULTS: The prevalence of chronic bronchitis was 9.3% among men and 8.5% among women. The concordance rate for chronic bronchitis was higher in monozygotic twins than in dizygotic twins among women; 0.30 vs. 0.17, but not...

  4. Chronic bronchitis in an elderly population

    DEFF Research Database (Denmark)

    Lange, Peter; Parner, Jan; Prescott, Eva;

    2003-01-01

    in order to describe the prevalence and prognostic implications of chronic bronchitis in individuals 65 years or older we analysed data from The Copenhagen City Heart Study.......in order to describe the prevalence and prognostic implications of chronic bronchitis in individuals 65 years or older we analysed data from The Copenhagen City Heart Study....

  5. Chronic Obstructive Pulmonary Disease (COPD) Includes: Chronic Bronchitis and Emphysema

    Science.gov (United States)

    ... Obstructive Pulmonary Disease (COPD) Includes: Chronic Bronchitis and Emphysema Recommend on Facebook Tweet Share Compartir Data are ... of adults who have ever been diagnosed with emphysema: 3.4 million Percent of adults who have ...

  6. Bronchitis

    Science.gov (United States)

    ... How Can I Help a Friend Who Cuts? Bronchitis KidsHealth > For Teens > Bronchitis Print A A A ... Bronchitis Prevention en español La bronquitis What Is Bronchitis? Bronchitis (pronounced: brong-KYE-tis) is an inflammation ...

  7. Mucociliary clearance in early simple chronic bronchitis

    International Nuclear Information System (INIS)

    Tracheobronchial mucociliary clearance was measured in 37 patients with early simple chronic bronchitis. A non-invasive radio-aerosol technique with inhalation of 99Tcm labelled 5-μm polystyrene particles followed by assessment of radio-nuclide distribution by posterior gamma-camera scans was employed. The mucociliary clearance of the bronchitics was significantly slower than clearance of a non-smoker control group. An interim analysis of the effect of treatment with a surfactant stimulating drug, ambroxol, suggested a dosage-dependent tendency to a faster mucociliary clearance than seen in placebo-treated bronchitics. (author)

  8. Radioisotope hepatography in patients with chronic bronchitis

    International Nuclear Information System (INIS)

    Examination carried out by means of radioisotope hepatography with bengal-rose-iodine 131 in 69 patients with chronic obstructive bronchitis associated with respiratory insufficiency of grades 1, 2, 3 at the phase of remission revealed disturbances of the absorptive-excretory function of the liver. A direct dependence was found between the intensity of disorder of the functionsl state of parenchymatous cells and degree of resperatory insufficiency in this category of patients. The disorders of the absorptive-excretory function of the liver were most pronounced in respiratory insufficiency of grade 3

  9. Hydrator Therapies for Chronic Bronchitis. Lessons from Cystic Fibrosis.

    Science.gov (United States)

    Bennett, William D; Henderson, Ashley G; Donaldson, Scott H

    2016-04-01

    Patients with the chronic bronchitis form of chronic obstructive pulmonary disease and cystic fibrosis share similar clinical features, including mucus obstruction of airways and the development of chronic/recurrent airways infections that often manifest as disease exacerbations. There is growing evidence that these diseases may have parallels in disease pathogenesis as well, including cystic fibrosis transmembrane conductance regulator dysfunction, mucus dehydration, and defective mucociliary clearance. As progress is made in the development of therapies that target the basic defects that lead to cystic fibrosis lung disease, it is possible that similar approaches could also benefit patients with chronic bronchitis. A deeper understanding of how tobacco smoke and other triggers of chronic bronchitis actually lead to disease, and exploration of the concept that therapies that restore cystic fibrosis transmembrane conductance regulator function, mucus hydration, and/or mucociliary clearance may benefit patients with chronic bronchitis, hold the prospect of significant progress in treating this prevalent disease. PMID:27115955

  10. Bronchial inflammation in chronic bronchitis assessed by measurement of cell products in bronchial lavage fluid.

    OpenAIRE

    Riise, G. C.; Ahlstedt, S.; Larsson, S.; Enander, I.; Jones, I; Larsson, P.; Andersson, B

    1995-01-01

    BACKGROUND--Bronchial inflammation in chronic bronchitis has not been characterised as well as in asthma. The present study was undertaken to assess whether a characteristic pattern of bronchial inflammatory markers could be found in patients with chronic bronchitis. METHODS--Bronchoscopy with bronchial lavage was performed in 42 patients with chronic bronchitis and in 13 healthy controls. Twenty three of the patients had non-obstructive chronic bronchitis and 19 had chronic bronchitis and ch...

  11. Risk of chronic bronchitis in twin pairs discordant for smoking

    DEFF Research Database (Denmark)

    Meteran, Howraman; Thomsen, Simon Francis; Harmsen, Lotte;

    2012-01-01

    It is well known that smoking is a major risk factor for lung disease and respiratory symptoms. We examined the association between smoking and the risk of chronic bronchitis in a large twin sample....

  12. Chronic Bronchitis - Multiple Languages: MedlinePlus

    Science.gov (United States)

    ... Somali) Bilingual PDF Health Information Translations Spanish (español) Bronquitis crónica Ukrainian (Українська) Bronchitis Бронхіт - Українська (Ukrainian) Bilingual ...

  13. Features of Chronic Bronchitis in Different Age Groups

    Directory of Open Access Journals (Sweden)

    Galina L. Ignatova

    2014-03-01

    Full Text Available Background: Lung diseases are assuming greater relevance and importance today. Chronic bronchitis is a self-nosology, which may precede the development of COPD, the importance of which can hardly be overestimated. The main problem in this disease is caused by late diagnosis and treatment due to the delay by patients in seeking medical help. The aim of the work was to study the distribution and exposure to tobacco smoke, especially chronic bronchitis, depending on various factors, including age. Methods: We examined 1779 persons, including 855 men and 924 women. The mean age of the population was 35.83±8.3 years. We conducted surveys and spirometry. The outcome was assessed after a bronchodilation test was performed with salbutamol 400 mcg. We performed all statistical analysis using software package Statistica 10. Results: We identified chronic bronchitis in 9.2% of the cases in the group of younger individuals and in 14.9% of the cases in the group of older individuals, during the active detection of chronic bronchitis using questionnaires. The prevalence of cigarette smoking was slightly higher among the younger (39.5% than the older persons (33.6%; the frequency of smoking in a group of chronic bronchitis was reliably higher. Also, in this group, the performance spirometry reliably decreased. Conclusions: Outpatient survey is an effective method of identifying chronic bronchitis. Smoking is a major risk factor in the group of young respondents and the prevalence of smoking is inversely related to the education level of the respondents, regardless of age. As the decline in the Forced Expiratory Volume (FEV1 and FEV1/FVC is the main criterion diagnosis of COPD, it revealed significant declines in the FEV1 of the younger smoking individuals, which may help to predict the development of COPD in the older age group.

  14. Acute Bronchitis

    Science.gov (United States)

    ... of bronchitis: acute and chronic. Most cases of acute bronchitis get better within several days. But your cough ... that cause colds and the flu often cause acute bronchitis. These viruses spread through the air when people ...

  15. Acute Bronchitis

    Science.gov (United States)

    Bronchitis is an inflammation of the bronchial tubes, the airways that carry air to your lungs. It ... chest tightness. There are two main types of bronchitis: acute and chronic. Most cases of acute bronchitis ...

  16. PULMONARY FUNCTION ADAPTATION TO OZONE IN SUBJECTS WITH CHRONIC BRONCHITIS

    Science.gov (United States)

    Twenty smokers with chronic bronchitis were exposed to 0.41 ppm ozone for 3 hr-day for 5 consecutive days and reexposed 4 days later to determine (1) if they are sensitive to ozone, (2) if they adapt, and (3) if the adaptation lasts longer than 4 days. There were significant decr...

  17. What Causes Bronchitis?

    Science.gov (United States)

    ... page from the NHLBI on Twitter. What Causes Bronchitis? Acute Bronchitis Infections or lung irritants cause acute bronchitis. The ... fire, also may lead to acute bronchitis. Chronic Bronchitis Repeatedly breathing in fumes that irritate and damage ...

  18. Carbon monoxide and exercise tolerance in chronic bronchitis and emphysema.

    OpenAIRE

    Calverley, P. M.; Leggett, R J; Flenley, D C

    1981-01-01

    The effects of carbon monoxide on exercise tolerance as assessed by the distance walked in 12 minutes were studied in 15 patients with severe chronic bronchitis and emphysema (mean forced expiratory volume in one second 0.56 1, mean forced vital capacity 1.54 1). Each subject walked breathing air and oxygen before and after exposure to sufficient carbon monoxide to raise their venous carboxyhaemoglobin concentration by 9%. There was a significant reduction in the walking distance when the pat...

  19. Controlled trial of supervised exercise training in chronic bronchitis.

    OpenAIRE

    D. J. Sinclair; Ingram, C G

    1980-01-01

    In a controlled trial of exercise retraining in patients with severe chronic bronchitis, 33 subjects were followed for a mean period of 10.3 months. The exercise programme was supervised once a week, and daily training comprised a 12-minute walk and simple stair climbing exercises. The subjects in the exercise group showed a highly significant improvement in their walking distance, attaining a maximum increase of 24% after eight to 12 months. There was also considerable subjective improvement...

  20. Canine chronic bronchitis: a pathophysiologic evaluation of 18 cases

    International Nuclear Information System (INIS)

    Eighteen dogs with chronic bronchitis were studied using physiologic, radiologic, microbiologic, and pathologic techniques. Twelve of these dogs were evaluated before and after two weeks of oral bronchodilator administration. Thoracic radiographs, tidal breathing flow-volume loops, radioaerosol ventilation scans, airway appearance at bronchoscopy, and airway pathology were abnormal in the majority of dogs studied. There was a significant relationship between abnormal ventilation scans and abnormal results for PaO2 and end-tidal airflow. Bronchoscopy revealed excessive mucus and inflammation of airway mucosa in all 16 dogs undergoing this procedure. Endoscopically obtained aerobic bacterial cultures grew mixed bacterial flora in only three dogs. Increased numbers of neutrophils in 14 dogs were detected by airway lavage cytology. A large number of eosinophils were seen in airway lavages obtained from two dogs; these two dogs also had evidence for eosinophilic bronchitis on endobronchial biopsy. Oral bronchodilator administration resulted in clinical and expiratory airflow improvements in most dogs, but had no effect on PaO2 or on the radioaerosol-scan abnormalities. The presence of both the physiologic and pathologic airway abnormalities of chronic bronchitis in dogs presented to a veterinary hospital with chronic unexplained cough was confirmed, suggesting that aerobic bacteria do not play an etiologic role in most cases

  1. 77 FR 59929 - Guidance for Industry on Acute Bacterial Exacerbations of Chronic Bronchitis in Patients With...

    Science.gov (United States)

    2012-10-01

    ... August 22, 2008 (73 FR 49684), which in turn revised the draft guidance for industry entitled ``Acute... ``Acute Bacterial Exacerbations of Chronic Bronchitis in Patients With Chronic Obstructive Pulmonary... treatment of acute bacterial exacerbations of chronic bronchitis in patients with chronic...

  2. [Chronic bronchitis and its sequelae. Therapy--prognosis--insurance medicine aspects].

    Science.gov (United States)

    Gillissen, A; Schmidt, E W

    1996-12-01

    Chronic bronchitis is of enormous epidemiological, socio-medical and economical importance. The main cause of chronic bronchitis is active but also passive cigarette smoking. Other etiologic factors are: viral or bacterial infections, chronic dust exposure in occupational settings and air pollution. Cease of cigarette smoking is considered the most valuable action in the treatment of the chronic bronchitis. In addition to drug therapy, physical therapy and other measures of rehabilitation may be a supportive benefit. ABout 10-20% of all patients with chronic bronchitis develop airway obstruction and/or lung emphysema. Obstructive bronchitis with or without lung emphysema should be treated with corticosteroids, beta 2-agonists and/or theophylline. Evidence for the socio-economical burden of chronic bronchitis and its complications are the enormous costs for the social economy (direct costs: in- and outpatient treatment; indirect costs: premature pensions, sick leave). PMID:9082644

  3. Clinical efficacy of Vyaghriharitaki Avaleha in the management of chronic bronchitis

    OpenAIRE

    Ram, Jaiprakash; Baghel, Madhav Singh

    2015-01-01

    Introduction: Vyaghriharitaki Avaleha (VHA), a polyherbal classical Ayurvedic formulation has been used in Kasa (cough), Swasa (asthma), Rajayakshma (tuberculosis) etc., conditions. Aim: To evaluate the clinical efficacy of VHA in the management of chronic bronchitis. Materials and Methods: Patients of chronic bronchitis were given 10 g of VHA twice a day with lukewarm water before meals for 12 weeks. Improvement in clinical symptoms of chronic bronchitis as the primary outcome measures and S...

  4. Measurement of tracheobronchial clearance after sauna in subjects with chronic bronchitis.

    OpenAIRE

    van Hengstum, M; Festen, J.; Corstens, F.

    1991-01-01

    The effect of sauna on tracheobronchial clearance was studied in five male patients with chronic bronchitis by a radioaerosol technique. No enhancement of tracheobronchial clearance could be detected.

  5. Assessment of the accuracy of thoracic radiography in the diagnosis of canine chronic bronchitis

    International Nuclear Information System (INIS)

    Thoracic radiographs from 23 dogs with chronic bronchitis were mixed with those taken from 11 dogs (matched by age and bodyweight) without respiratory disease and interpreted twice by two blinded, independent examiners in an attempt to determine the accuracy of radiography for the diagnosis of chronic bronchitis. The only radiographic signs found more often in dogs with chronic bronchitis were thickening of the bronchial walls and increased numbers of visible bronchial walls (P 0.64). The accuracy of radiographic diagnosis of chronic bronchitis is limited principally by insensitivity for bronchial lesions

  6. Childhood respiratory infection and adult chronic bronchitis in England and Wales.

    OpenAIRE

    Barker, D J P; Osmond, Clive

    1986-01-01

    The high mortality from chronic bronchitis in England and Wales and the excess of urban over rural mortality are unexplained. On dividing England and Wales into 212 local authority areas a strong geographical relation was found between death rates from chronic bronchitis and emphysema in 1959-78 and infant mortality from bronchitis and pneumonia during 1921-5. It was concluded that this relation provided strong evidence of a direct casual link between acute lower respiratory infection in earl...

  7. Factors affecting the decline of ventilatory function in chronic bronchitis.

    OpenAIRE

    Campbell, A H; Barter, C. E.; O'Connell, J M; Huggins, R

    1985-01-01

    Ninety six middle aged male patients with chronic bronchitis with relatively well preserved ventilatory function who were resident in Queensland, New South Wales, or Victoria took part in a prospective study to determine the relationship of various factors to the rate of decline of the FEV1. Thirty of the subjects withdrew, leaving 66 to be followed for four to six years. The mean rate of decline of the FEV1 was 58.6 (SD 51.4) ml/year. The subjects' ventilatory responses to bronchodilator and...

  8. Atopy: a predisposing factor for chronic bronchitis in Finland.

    OpenAIRE

    Terho, E O; Koskenvuo, M.; Kaprio, J

    1995-01-01

    STUDY OBJECTIVE--To investigate the predictive value of atopy, smoking, and living in a farm environment in the development of chronic bronchitis. DESIGN--This was a cross sectional and longitudinal study. SETTING--Postal surveys carried out in Finland in 1975 and 1981. PARTICIPANTS--The study was part of the Finnish twin cohort study, which included adult twin pairs born in Finland before 1958. The cross sectional sample consisted of 18,351 subjects, including 1025 prevalent cases, and the f...

  9. Prevalence and risk factors for chronic bronchitis and farmer's lung in French dairy farmers.

    OpenAIRE

    Dalphin, J.C.; Debieuvre, D.; Pernet, D.; Maheu, M F; Polio, J. C.; Toson, B.; Dubiez, A.; Monnet, E; Laplante, J. J.; Depierre, A

    1993-01-01

    The prevalence of chronic bronchitis and of clinical farmer's lung was studied in 30 districts of the French Doubs province in relation to individual (age, sex, smoking) and geographical (altitude) factors. 5703 exclusively dairy farmers (response rate 83%) participated in the study by answering a medical questionnaire. Prevalences of chronic bronchitis and clinical farmer's lung were 9.3% and 1.4% respectively. A logistic regression model was used to evaluate risk factors for chronic bronchi...

  10. Cystic Fibrosis Transmembrane Conductance Regulator Activation by Roflumilast Contributes to Therapeutic Benefit in Chronic Bronchitis

    OpenAIRE

    Lambert, James A.; Raju, S. Vamsee; Tang, Li Ping; McNicholas, Carmel M.; Li, Yao; Courville, Clifford A.; Farris, Roopan F.; Coricor, George E.; Smoot, Lisa H.; Mazur, Marina M.; Dransfield, Mark T; Bolger, Graeme B.; Rowe, Steven M

    2014-01-01

    Cigarette smoking causes acquired cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction and is associated with delayed mucociliary clearance and chronic bronchitis. Roflumilast is a clinically approved phosphodiesterase 4 inhibitor that improves lung function in patients with chronic bronchitis. We hypothesized that its therapeutic benefit was related in part to activation of CFTR. Primary human bronchial epithelial (HBE) cells, Calu-3, and T84 monolayers were exposed to whol...

  11. Determinants of chronic bronchitis and lung dysfunction in Western Australian gold miners

    OpenAIRE

    Humble, C; Wing, S.

    1989-01-01

    The relation of chronic bronchitis and respiratory dysfunction to age, tobacco smoking, and occupational exposure to surface and underground mining operations were examined in a cross sectional survey of 1363 men employed in the Kalgoorlie mining industry in 1985. Overall, the prevalence of chronic bronchitis was 14%. Eleven per cent of the workers had obstructive lung disorder (FEV1/FVC less than 0.70) and 9% had restrictive lung disorder (FVC less than 0.80 of predicted for height and age)....

  12. Clinical Peculiarities of Recurrent and Chronic Bronchitis in Children (Part 1)

    OpenAIRE

    Makian, M. V.; Harhaun, V. A.; Maidannyk, V. H.

    2015-01-01

    Subjective manifestations in children with recurrent and chronic bronchitis were the subject of the research.The objective of the research was to evaluate the main clinical manifestations of recurrent and chronic bronchitis, analyze risk factors and preconditions for their occurence in children.Materials and methods of research. The comprehensive clinical and anamnestic examination of 120 children with bronchopulmonary pathology at the age of 3 to 18 (average age was 10.5±1.1 years) was condu...

  13. Effects of N2-laser radiation on the immune system cells of patients with chronic bronchitis

    Science.gov (United States)

    Provorov, Alexander S.; Kozhevnikova, T. A.; Salmin, Vladimir V.

    2001-05-01

    In spite of various investigations devoted to a problem of chronic bronchitis, many problems concerning both the reasons of the origin of this disease, and the essence of the processes, explicating in the bronchial tubes, especially on early stages of the disease, remain insufficiently studied. It makes it difficult to use an integrated approach to chronic bronchitis, that would reflect the peculiarities of its etiology, pathogenesis, its clinical course and efficiency of the therapy. During the last years the data of the clinical laboratory analysis of chronic bronchitis in connection with its immune therapy have been accumulated. In the literature there is a lot of information about the violation of immune reactions in the organism of patients, methods of the immune therapy, the data of the successful application of the intravenous laser therapy in the treatment of obstructive chronic bronchitis and bronchial asthma. However, there is no research explaining the mechanisms of the laser radiation impact on the immune status of patients suffering from chronic bronchitis. According to this it has become extremely urgent to research the mechanisms of the laser radiation impact on immune competent cells of patients suffering from chronic bronchitis.

  14. [Impaired lung function in patients with moderate chronic obstructive bronchitis].

    Science.gov (United States)

    Nefedov, V B; Popova, L A; Shergina, E A

    2004-01-01

    VC, FVC, FEV1, FEV1/VC%, PEF, MEF25, MEF50, MEF75, TLC, TGV, RV, Raw, Rin, Rex, DLCO-SS, paO2 and paCO2 were determined in 22 patients with moderate chronic obstructive bronchitis (FEV1, 79-50% of the normal value). All the patients were found to have impaired bronchial patency, 90.9% of the patients had lung volume and capacity changes; pulmonary gas exchange dysfunction was present in 72.7%. Bronchial patency impairments were manifested by a decrease in FEV1, FEV1/VC%, PEF, MEF25, MEF50, MEF75, and an increase in Raw, Rin, Rex. Changes in the lung volumes and capacities appeared as higher RV, TGV, TLC, lower VC and FVC. Pulmonary gas exchange dysfunction showed up as a reduction in pO2 and DLCO-SS a reduction and an increase in paCO2. The magnitude of the functional changes observed in most patients was low. Significant and pronounced disorders were seen in one third of the patients. PMID:15719666

  15. Psychological Distress in Women with Chronic Bronchitis in a Fishing Community in the Niger Delta Region of Nigeria

    OpenAIRE

    Victor Aniedi Umoh; Andrew Ibok; Bassey Edet; Ekpe Essien; Festus Abasiubong

    2013-01-01

    Background. Biomass smoke exposure is a known risk factor for chronic bronchitis. Psychiatric comorbidities may have significant impact on the quality of life of patients with chronic bronchitis. Methods. Women who engage in fish preservation by drying over burning firewood in a fishing community were recruited for this survey. The British medical research questionnaire was used to determine chronic bronchitis, and psychological distress was determined using the hospital anxiety and depressio...

  16. Study on the serum thyroid hormones levels in patients with acute and chronic bronchitis

    International Nuclear Information System (INIS)

    Objective: To study the changes of serum thyroid hormones levels in patients with acute bronchitis and chronic bronchitis. Methods: Serum T3, FT3, T4, FT4, TSH (with CLIA) and rT3 (with RIA) levels were measured in 107 patients with acute bronchitis, 87 patients with chronic bronchitis and 47 controls. Results: The serum thyroid hormones levels in all these patients were not significantly different from those in controls (P>0.05), except that the serum T3 levels were significantly lower and rT3 levels significantly higher (P3 levels increased significantly and rT3 levels decreased significantly after treatment (P3 levels could reflect the severity of the disease, the T3/rT3 ratio was lowest in the 10 deceased patients. (authors)

  17. Psychological Distress in Women with Chronic Bronchitis in a Fishing Community in the Niger Delta Region of Nigeria

    Directory of Open Access Journals (Sweden)

    Victor Aniedi Umoh

    2013-01-01

    Full Text Available Background. Biomass smoke exposure is a known risk factor for chronic bronchitis. Psychiatric comorbidities may have significant impact on the quality of life of patients with chronic bronchitis. Methods. Women who engage in fish preservation by drying over burning firewood in a fishing community were recruited for this survey. The British medical research questionnaire was used to determine chronic bronchitis, and psychological distress was determined using the hospital anxiety and depression scale. Results. A total of 342 women were recruited for this study and 63 of them had chronic bronchitis. 96 women had features suggestive of psychological distress: 57 (16.6% women with anxiety, 51 (14.9% women with depression and 12 women (3.5% had combined features. Psychological distress was more common among women with chronic bronchitis. Anxiety was significantly associated with chronic bronchitis and the level of biomass exposure while depression was significantly associated with chronic bronchitis, level of exposure, and a history of sleeping in the fish smoking room. Conclusion. Anxiety and depression show significant association with chronic bronchitis among women with biomass smoke exposure with the level of exposure having an aggravating effect on the relationship.

  18. Nebuhaler or nebulizer for high dose bronchodilator therapy in chronic bronchitis: a comparison.

    Science.gov (United States)

    Allen, M B; Pugh, J; Wilson, R S

    1988-10-01

    We have compared the clinical efficacy of high dose terbutaline sulphate (10 mg four times daily) delivered by either a Nebuhaler or jet nebulizer in 13 patients with chronic bronchitis in a 2-week, open, crossover study. Both treatment regimens improved run-in symptom scores but no significant changes were recorded in peak flow and spirometry. Side-effects were more common with the Nebuhaler and more patients preferred the nebulizer. However, the Nebuhaler is an alternative therapeutic option for delivery of high doses of bronchodilators in patients with chronic bronchitis. PMID:3076792

  19. Dynamic scintigraphy of the lungs with 133Xe in chronic bronchitis

    International Nuclear Information System (INIS)

    A method of dynamic scintigraphy with 133Xe Was used to study regional ventilation and regional pulmonary blood flow in 58 persons (14 practically healthy persons and 44 patients with chronic bronchitis). This data obtained were assessed visUally and sub ected to a quantitative processing according to the above-mentioned program. Quantitative distinctions in regional values of the residnal volume, a ratio of the residual volume to the general capacity, the time of mixing, a half-period of washing off made it possible to distinguish clearly between two forms of chronic bronchitis (non-obstructive and a form with the noticeable obstructive syndrome)

  20. Lung mucociliary transport function in chronic bronchitis and radionuclide methods of its investigation (a review)

    International Nuclear Information System (INIS)

    Several methods for studying lung clearance of smokers and non-smoking patients with chronic bronchitis (CB) are described. Modified technique for investigating mucociliary transport (MCT) in CB patients, using 99mTc-macroaggregate of human serum albumin, is suggested. The method enables to examine more patients and obtain the most comprehensive data on MCT state on any level of tracheobronchial tree

  1. Radionuclide methods of assessment of external respiration in chronic obstructive bronchitis

    International Nuclear Information System (INIS)

    A trial was designet to study shifts in various mechanisms of external respiration (ER)distress in chronic obstructive bronchitis by type of respiration insufficiency (RI). Combinet clinicoroentgenological, spirographic, endoscopic and radionuclide (133Xe radiopneumography and 99Tc scintigraphy) examinations were conducted in 66 patients. The following parameters appeared most informative in studying ER in the bronchitis patients with radionuclide techniques: the volume of ventilated alveoli, respiratory capacity, total and functional residual lung capacity, index ventilation/blood flow, capillary blood flow, time of half elimination of Xe from the alveoli and vascular bed. The above parameters change for the worse with progressive deterioration of external respiration

  2. Clinical X-ray characteristics of chronic bronchitis in workers of coal mines

    International Nuclear Information System (INIS)

    100 workers of coal mines with chronic dusty bronchitis are examined. The roentgenological manifestations of different stages of the diseases with respect to the clinical picture and function of external breath according to the data of roentgenopneumopolygraphy, are characterized. The attention is paid to a most pronounced violation of external breath function in this category of patients. The peculiarities of clinico-roentgenological picture of dust bronchitis found should be taken into account when solving the problems of medical labor examination. 8 refs.; 3 figs

  3. Correlates of COPD and chronic bronchitis in nonsmokers: data from a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Khayat G

    2012-09-01

    Full Text Available Mirna Waked,1 Joseph Salame,2 Georges Khayat,3 Pascale Salameh41Faculty of Medicine, Balamand University, and St George Hospital, Beirut, Lebanon; 2Lebanese University, Faculty of Medicine, Beirut, Lebanon; 3Faculty of Medicine, St Joseph University and Hôtel Dieu de France Hospital, Beirut, Lebanon; 4Lebanese University, Faculties of Pharmacy and Public Health, Beirut, LebanonPurpose: Our objective was to assess the prevalence of chronic bronchitis and chronic obstructive pulmonary disease (COPD and their correlates among a Lebanese nonsmoker group.Material and methods: A cross-sectional study was conducted between October 2009 and September 2010, using a multistage cluster sample throughout Lebanon including Lebanese residents aged 40 years and above with no exclusion criteria. Pre- and postbronchodilator spirometry measurements were performed and carbon monoxide level was measured in exhaled air. COPD was defined and classified according to the Global Initiative for Chronic Obstructive Lung Disease guidelines or according to the lower limit of normal (forced expiratory volume in 1 second/forced vital capacity postbronchodilator < 5th percentile of the healthy population having the same age and sex. Chronic bronchitis was defined by the declaration of morning cough and expectorations for more than 3 months a year over more than 2 years in individuals with normal spirometry.Results: Out of 2201 individuals, 732 were never-smokers: 25 (3.4% of them had COPD, and 86 (11.75% fulfilled the definition of chronic bronchitis. Correlates of COPD included a childhood respiratory disease, house heated by diesel, and older age. On the other hand, correlates of chronic bronchitis included childhood respiratory diseases, living in southern Lebanon versus other regions, heating home by gas, older age, number of smokers at work, and lower height.Conclusion: A substantial percentage of the nonsmoking population may exhibit chronic bronchitis or COPD. The

  4. Moxifloxacin in the management of exacerbations of chronic bronchitis and COPD

    OpenAIRE

    Miravitlles, Marc

    2007-01-01

    Bacteria are isolated in more than 50% of exacerbations of chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD). The most prevalent respiratory pathogens include Gram-positive (Streptococcus pneumoniae) and Gram-negative (Haemophilus influenzae, Moraxella catarrhalis) microorganims. Moxifloxacin is a fourth-generation fluoroquinolone that has been shown to be effective against respiratory pathogens, including atypicals and those resistant to most common antibiotics. The bi...

  5. Impact of heterozygote CFTR Mutations in COPD patients with Chronic Bronchitis

    OpenAIRE

    Raju, S. Vamsee; Tate, Jody H; Peacock, Sandra KG; Fang, Ping; Oster, Robert A.; Dransfield, Mark T.; Steven M Rowe

    2014-01-01

    Background Cigarette smoking causes Chronic Obstructive Pulmonary Disease (COPD), the 3rd leading cause of death in the U.S. CFTR ion transport dysfunction has been implicated in COPD pathogenesis, and is associated with chronic bronchitis. However, susceptibility to smoke induced lung injury is variable and the underlying genetic contributors remain unclear. We hypothesized that presence of CFTR mutation heterozygosity may alter susceptibility to cigarette smoke induced CFTR dysfunction. Con...

  6. Therapeutic Approaches to Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in Chronic Bronchitis.

    Science.gov (United States)

    Solomon, George M; Raju, S Vamsee; Dransfield, Mark T; Rowe, Steven M

    2016-04-01

    Chronic obstructive pulmonary disease is a common cause of morbidity and a rising cause of mortality worldwide. Its rising impact indicates the ongoing unmet need for novel and effective therapies. Previous work has established a pathophysiological link between the chronic bronchitis phenotype of chronic obstructive pulmonary disease and cystic fibrosis as well as phenotypic similarities between these two airways diseases. An extensive body of evidence has established that cigarette smoke and its constituents contribute to acquired dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) protein in the airways, pointing to a mechanistic link with smoking-related and chronic bronchitis. Recent interest surrounding new drugs that target both mutant and wild-type CFTR channels has paved the way for a new treatment opportunity addressing the mucus defect in chronic bronchitis. We review the clinical and pathologic evidence for modulating CFTR to address acquired CFTR dysfunction and pragmatic issues surrounding clinical trials as well as a discussion of other ion channels that may represent alternative therapeutic targets. PMID:27115953

  7. Effect of smoking cessation on airway inflammation of rats with chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    LI Qing-yun; HUANG Shao-guang; WAN Huan-ying; WU Hua-cheng; ZHOU Tong; LI Min; DENG Wei-wu

    2007-01-01

    Background Smoking is the major cause of airway inflammation in chronic obstructive pulmonary disease (COPD),and smoking cessation is regarded as one of the important strategies for prevention and treatment of the inflammation.The inflammation of the chronic airway may be present and deteriorated even if the COPD patients stop smoking.Whether and how early smoking cessation affects the progress of inflammation is still obscure. This study was conducted to find the appropriate time for smoking cessation to terminate the airway inflammation in rats with smoke-induced chronic bronchitis.Methods A rat model of COPD was established by passively inhaling smoke mixture. Fifty-four young male Sprague-Dawley rats were randomly divided into 9 groups with different periods of smoke exposure and different time points of cessation. The inflammation markers to be detected included inflammatory cells in the bronchoalveolar lavage fluid (BALF), the myeloperoxidose (MPO) activity, the morphologic changes and the expression of ICAM-1 on the airway epithelium.Results When smoking was terminated at early stage, the inflammatory markers and related indexes were different from those of the typical chronic bronchitis group (group M7) (P<0.01). The pathologic score of group SC7 (2 weeks of smoking cessation after occurrence of typical chronic bronchitis ) was not different from that of group M7, and the level of ICAM-1 was still up-regulated (compared to group M7, P>0.05). Meanwhile, most of inflammatory cells in BALF were neutrophils compared to other groups (P<0.01).When smoking was terminated, the MPO activity was significantly lower than that of group M7 (P<0.01).Conclusions Smoking cessation at early stage can effectively inhibit the inflammatory reaction of COPD. Once chronic bronchitis occurs, little could be improved by smoking cessation.

  8. Comparison of right ventricular weight at necropsy in interstitial pulmonary fibrosis and in chronic bronchitis and emphysema.

    OpenAIRE

    Packe, G E; Cayton, R M; Edwards, C. W.

    1986-01-01

    The ventricular weights in 43 patients with interstitial pulmonary fibrosis were retrospectively compared with those in 172 patients with emphysema and chronic bronchitis. The mean right ventricular weight of patients with interstitial pulmonary fibrosis and those with emphysema and chronic bronchitis was 85.5 g (SD 23.2) and 88.8 g (34.3), respectively. Thirty five patients (81%) with interstitial pulmonary fibrosis had a right ventricular weight over 65 g compared with 124 (72%) of those wi...

  9. Investigation into the effect of fenoterol on mucociliary clearance in patients with chronic bronchitis

    International Nuclear Information System (INIS)

    We investigated the effects of fenoterol, a selective β2 adrenoceptor stimulant, on mucociliary clearance in 12 patients with chronic bronchitis. Mucociliary clearance was measured with a scintillation camera after inhalation of a 99mTc labeled aerosol. Fenoterol was administered one h after acquisition commenced and imaging was maintained for a further two h. Three regions of interest (ROI) were selected over each lung to generate time activity curves. Corrections for decay, alveolar deposition (using 24 h image), cough and movement of activity through each ROI were carried out. An exponential function was fitted to the clearance curves to determine clearance rates. The increase in percentage clearance after fenoterol administration for the left and right whole lung ROI was 35% and 36% per h respectively (P = 0.006 and 0.020). Fenoterol enhances cilial clearance in chronic bronchitis patients. (orig.)

  10. Investigation of Neurokinin‐1 Receptor Antagonism as a Novel Treatment for Chronic Bronchitis in Dogs

    OpenAIRE

    Grobman, M.; Reinero, C.

    2016-01-01

    Background Canine chronic bronchitis (CCB) results in cough lasting ≥2 months and airway inflammation. Adverse effects include risk of secondary infection associated with lifelong corticosteroid administration and prompt investigation into alternative therapies. Neurogenic pathways mediated by tachykinins that bind neurokinin (NK) 1 receptors may induce cough and airway inflammation. Maropitant,1 a NK‐1 receptor antagonist, has been advocated for treatment of CCB based on anecdotal improvemen...

  11. [Effects of essential oil on lipid peroxidation and lipid metabolism in patients with chronic bronchitis].

    Science.gov (United States)

    Siurin, S A

    1997-01-01

    Natural concentrations of some essential oils were examined for effects on the system lipid peroxidation-antioxidant defense and lipid metabolism in 150 patients with chronic bronchitis. Lowering of plasm levels of dienic conjugates and ketons, activation of catalase in red cells characteristic of antioxidant effect were observed in exposure to essential oils of rosemary, basil, fir, eucalyptus. Lavender essential oil promotes normalization of the level of total lipids, ratio of total cholesterol to its alpha-fraction. PMID:9490339

  12. Radioisotopic examinations of the functional state of reticuloendothelial cells of the liver in chronic bronchitis

    International Nuclear Information System (INIS)

    Radioisotopic hepatography carried out in 65 patients with chronic obstructive bronchitis and respiratory insufficiency (grades 1-2 and 3) at the phase of remission revealed disorders of the liver circulation and absorptive capacity of reticuloendothelial liver cells. There was a direct dependence between the degree of liver circulation disorders, inhibition of absorptive function of the reticuloendothelial cells of the liver and degree of respiratory insufficiency in these patients

  13. Immunological status in participants of Chernobyl accident clean-up with chronic bronchitis

    International Nuclear Information System (INIS)

    Immunological status in participants of Chernobyl accident clean-up with chronic bronchitis was investigated. Patients had more tension elements of immune system at increased level of obstruction. Adaptive reaction in the liquidators was formed on lower level of organism reaction and imbalance in immune competence subsystems developed. This phenomenon is a negative prognostic sign of more serious disease and can cause invalidation of the patients

  14. Clinical and radiological diagnosis of chronic pneumonia in pneumoconiosis and dust bronchitis

    International Nuclear Information System (INIS)

    Clinical and radiologic symptomatology of chronic pneumonia is described for pneumoconiosis and chronic dust bronchitis. Combined X-ray methods of examination permit the physicians to discover this complication in dust diseases of the lungs in the presence of diffuse pneumosclerotic changes in 76.5+-3 % of cases. These data approach the values of chronic pneumonia incidence among the population. Chronic pneumonia diagnosis should be complex. If no less than 2 to 3 X-ray signs of the disease have been found simultaneously, the significance of radiologic diagnosis of chronic pneumonia in dust pathology of the lungs, rises. Radiologic examination, supported by clinical, anamnestic and laboratory data, allows one to differentiate chronic pneumonia from coniotuberculosis. Chest X-rays in dust pathology of the lungs, complicated by chronic pneumonia, should be carried out with regard to clinical indications

  15. Spirometric abnormalities associated with chronic bronchitis, asthma, and airway hyperresponsiveness among boilermaker construction workers

    Energy Technology Data Exchange (ETDEWEB)

    Hauser, R.; Eisen, E,A,; Pothier, L,; Lewis, D,; Bledsoe, T,; Christiani, D.C. [Harvard University, Boston, MA (United States). School of Public Health

    2002-06-01

    In a 2-year longitudinal study of boilermaker construction workers, authors found a significant association between working at oil-fired, coal-fired, and gas-fired industries during the past year and reduced lung function. In the present study, authors investigated whether chronic bronchitis, asthma, or baseline methacholine airway responsiveness can explain the heterogeneity in lung function response to boilermaker work. Exposure was assessed with a work history questionnaire. Spirometry was performed annually to assess lung function. A generalized estimating equation approach was used to account for the repeated-measures design. One hundred eighteen boilermakers participated in the study. Self-reported history of chronic bronchitis and asthma were associated with a larger FEV1 reduction in response to workplace exposure at coal-fired and gas-fired industries. Although a high prevalence (39%) of airway hyperresponsiveness (provocative concentration of methacholine causing a 20% fall in FEVI of {lt} 8 mg/mL) among boilermakers was found, there was no consistent pattern of effect modification by airway responsiveness. Conclusions: Although chronic bronchitis and asthma were associated with a greater loss in lung function in response to hours worked as a boilermaker, and therefore they acted as effect modifiers of the exposure-lung function relationship, airway hyperresponsiveness did not. However, the high prevalence of airway hyperresponsiveness found in the cohort may be a primary consequence of long-term workplace exposure among boilermakers.

  16. Cystic Fibrosis Transmembrane Conductance Regulator Activation by Roflumilast Contributes to Therapeutic Benefit in Chronic Bronchitis

    Science.gov (United States)

    Lambert, James A.; Raju, S. Vamsee; Tang, Li Ping; McNicholas, Carmel M.; Li, Yao; Courville, Clifford A.; Farris, Roopan F.; Coricor, George E.; Smoot, Lisa H.; Mazur, Marina M.; Dransfield, Mark T.; Bolger, Graeme B.

    2014-01-01

    Cigarette smoking causes acquired cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction and is associated with delayed mucociliary clearance and chronic bronchitis. Roflumilast is a clinically approved phosphodiesterase 4 inhibitor that improves lung function in patients with chronic bronchitis. We hypothesized that its therapeutic benefit was related in part to activation of CFTR. Primary human bronchial epithelial (HBE) cells, Calu-3, and T84 monolayers were exposed to whole cigarette smoke (WCS) or air with or without roflumilast treatment. CFTR-dependent ion transport was measured in modified Ussing chambers. Airway surface liquid (ASL) was determined by confocal microscopy. Intestinal fluid secretion of ligated murine intestine was monitored ex vivo. Roflumilast activated CFTR-dependent anion transport in normal HBE cells with a half maximal effective concentration of 2.9 nM. Roflumilast partially restored CFTR activity in WCS-exposed HBE cells (5.3 ± 1.1 μA/cm2 vs. 1.2 ± 0.2 μA/cm2 [control]; P < 0.05) and was additive with ivacaftor, a specific CFTR potentiator approved for the treatment of CF. Roflumilast improved the depleted ASL depth of HBE monolayers exposed to WCS (9.0 ± 3.1 μm vs. 5.6 ± 2.0 μm [control]; P < 0.05), achieving 79% of that observed in air controls. CFTR activation by roflumilast also induced CFTR-dependent fluid secretion in murine intestine, increasing the wet:dry ratio and the diameter of ligated murine segments. Roflumilast activates CFTR-mediated anion transport in airway and intestinal epithelia via a cyclic adenosine monophosphate–dependent pathway and partially reverses the deleterious effects of WCS, resulting in augmented ASL depth. Roflumilast may benefit patients with chronic obstructive pulmonary disease with chronic bronchitis by activating CFTR, which may also underlie noninfectious diarrhea caused by roflumilast. PMID:24106801

  17. [Lung dysfunction in patients with severe chronic obstructive bronchitis].

    Science.gov (United States)

    Nefedov, V B; Popova, L A; Shergina, E A

    2005-01-01

    VC, FVC, FEV1, FEV1/VC%, PEF, MEF25, MEF50, MEF75, TCL, TGV, RV, Raw, Rin, Rex, DLCO-SS, PaO2, and PaCO2 were determined in 36 patients with severe chronic obstructive lung disease (FEV1 TGV, and TLC, and by decreased VC and FVC; pulmonary gas exchange dysfunction showed up as lowered PaO2 and DLCO-SS, as decreased or increased PaCO2. The observed bronchial patency disorders varied from significant to severe; functional changes in lung volumes and capacities were mild to severe. PMID:15938497

  18. [Lung dysfunction in patients with mild chronic obstructive bronchitis].

    Science.gov (United States)

    Nefedov, V B; Popova, L A; Shergina, E A

    2004-01-01

    VC, FVC, FEV1, FEV1/VC%, PEF, MEF25, MEF50, MEF75, TCL, TGV, RV, Ravt, Riin, Rex, DLCO-SS, PaO2, and PaO2 were determined in 33 patients with mild chronic obstructive lung disease (FEV1 > 70% of the normal value). All the patients were found to have impaired bronchial patency; most (63.6%) patients had lung volume and capacity changes, almost half (45.5%) the patients had pulmonary gas exchange dysfunction. Impaired bronchial patency mainly appeared as decreased MEF50, MEF15, and FEV1/VC%; altered lung volumes and capacities manifested chiefly by increased RV and decreased VC; pulmonary gas exchange dysfunction showed up primarily as lowered PaO2. The magnitude of the observed functional changes was generally slight. MEF50, MEF75, FEV1/VC%, and VC dropped to 59-20 and 79-70% of the normal value, respectively. RV increased up to 142-196% of the normal value; PaO2 reduced up to 79-60% mm Hg. PMID:15478560

  19. Effect of sputum processing with dithiothreitol on the detection of inflammatory mediators in chronic bronchitis and bronchiectasis

    OpenAIRE

    Woolhouse, I.; Bayley, D; Stockley, R

    2002-01-01

    Background: Sputum analysis is used increasingly to assess airway inflammation in patients with chronic obstructive pulmonary disease, including those with chronic bronchitis and bronchiectasis. However, it is not known whether dithiothreitol (DTT), a reducing mucolytic agent regularly used to homogenise sputum, affects the detection of inflammatory mediators in the sputum soluble phase from such patients.

  20. Study on the salivary contents of secretory immunoglobulin A (SigA) and lysome (Lys) in patients with chronic bronchitis

    International Nuclear Information System (INIS)

    Objective: To study the sailic levels of SIgA and lys in patients with chronic bronchitis. Methods: Sailic SIgA (with RIA) and lys (with immunodiffusionassay) levels were measured in 38 patients with chronic bronchitis both before and after treatment as well as in 35 controls. Results: Before treatment the saliac SIgA and lys levels in the patients were significantly higher than those in controls (P<0.01). After treatment for 2 weeks, the sailic SIgA and lys levels, though dropped markedly, remained significantly higher than those in controls (P<0.05). Conclusion: Changes of sailic SIgA and lys levels content after treatment might be of prognostic importance in patients with chronic bronchitis. (authors)

  1. [Effects of occupational factors on the natural course of chronic bronchitis in a prospective observation of the industrial population].

    Science.gov (United States)

    Jedrychowski, W

    1978-01-01

    Frequence of occurrence and dynamics of chronic bronchitis symptoms as well as barrier syndrome in the examined men in a plant was connected primarily with tobacco smoking and less with the age. Mean values FEV1 depended on the age of examined workers and the rate of spirometric values decrease increased with the age and was connected with smoking habit. It has been ascertained that there is a direct relationship between air contamination with dusts and fluorides and frequency of occurrence of chronic bronchitis symptoms, maintenance of the symptoms for 5 years and decrease of FEV1 value at that period especially in a group of smokers. PMID:723614

  2. Study of regional ventilation of the lungs in patients with chronic bronchitis, making use of scanning densitometry of tomograms

    International Nuclear Information System (INIS)

    Method for investigation of regional ventilation of the lungs with the use of tomography and scanning densitometry was suggested. The method makes it possible to assess the expressiveness of changes in the lungs in patients with chronic bronchitis before and in the process of treatment. The new method permitted to reveal the disturbances of regional ventilation of the lungs in patients with chronic obstructive and non-obstructive bronchitis and to establish a latent respiratory insufficiency. The data of suggested method of scanning densitometry of tomograms of the lungs are in agreement with results of examinations of external respiration function

  3. Efficacy and Tolerability of 5- vs 10-Day Cefixime Therapy in Acute Exacerbations of Chronic Bronchitis.

    Science.gov (United States)

    Lorenz, J; Steinfeld, P; Drath, L; Keienburg, T; Troester, K

    1998-01-01

    The efficacy and tolerability of oral cefixime 400mg once daily for 5 days was compared with standard 10-day therapy in a multicentre, double-blind, randomised, controlled clinical trial of 222 patients with acute exacerbations of chronic bronchitis. Clinical and bacteriological efficacy were assessed after 6, 11 and 30 days. A total of 167 patients were evaluable for efficacy on a per-protocol basis. Clinical efficacy (cure or improvement based on the quality and quantity of expectorated sputum and symptoms of dyspnoea) at day 11 was statistically equivalent (p < 0.01) between the treatment groups, with a successful clinical response achieved in 91% (5-day) and 89% (10-day) of patients. Bacteriological efficacy was also similar with 5- and 10-day treatment. During treatment, more patients reported an adverse event possibly or probably related to the study medication in the 10-day than in the 5-day treatment group (19 vs 14%). However, this difference was not statistically significant. Oral cefixime 400mg once daily is an effective and well tolerated treatment for acute exacerbations of chronic bronchitis. Short-term (5-day) therapy offers clinical efficacy similar to that of standard (10-day) therapy. PMID:18370461

  4. Airflow, transport and regional deposition of aerosol particles during chronic bronchitis of human central airways.

    Science.gov (United States)

    Farkhadnia, Fouad; Gorji, Tahereh B; Gorji-Bandpy, Mofid

    2016-03-01

    In the present study, the effects of airway blockage in chronic bronchitis disease on the flow patterns and transport/deposition of micro-particles in a human symmetric triple bifurcation lung airway model, i.e., Weibel's generations G3-G6 was investigated. A computational fluid and particle dynamics model was implemented, validated and applied in order to evaluate the airflow and particle transport/deposition in central airways. Three breathing patterns, i.e., resting, light activity and moderate exercise, were considered. Using Lagrangian approach for particle tracking and random particle injection, an unsteady particle tracking method was performed to simulate the transport and deposition of micron-sized aerosol particles in human central airways. Assuming laminar, quasi-steady, three-dimensional air flow and spherical non-interacting particles in sequentially bifurcating rigid airways, airflow patterns and particle transport/deposition in healthy and chronic bronchitis (CB) affected airways were evaluated and compared. Comparison of deposition efficiency (DE) of aerosols in healthy and occluded airways showed that at the same flow rates DE values are typically larger in occluded airways. While in healthy airways, particles deposit mainly around the carinal ridges and flow dividers-due to direct inertial impaction, in CB affected airways they deposit mainly on the tubular surfaces of blocked airways because of gravitational sedimentation. PMID:26541595

  5. [Clinical contribution of the newer fluoroquinolones in acute bacterial exacerbation of chronic bronchitis].

    Science.gov (United States)

    Niederman, M S

    1999-01-01

    Acute exacerbations occur frequently in patients with chronic bronchitis and the majority of these patients benefit from antimicrobial therapy. The ideal antimicrobial agent for the management of acute exacerbations of chronic bronchitis (AECB) should have good activity against the common bacterial pathogens associated with these exacerbations (non-typable Haemophilus influenzae, Moraxella catarrhalis and pneumococci); it should be resistant to bacterial betalactamases; penetrate well into pulmonary tissues and secretions; kill bacteria without inducing excessive airway inflammation; be easy to take (given once or twice a day) in order to ensure high patient compliance, and be cost-effective. Fluoroquinolone antibiotics have demonstrated efficacy in the treatment of AECB, but because of the limited activity of certain older agents in this class when administered in standard doses against Streptococcus pneumoniae, they have not be extensively used for this indication. Newer agents including levofloxacin, grepafloxacin, sparfloxacin and trovafloxacin have excellent activity against both Gram positive and Gram negative pathogens likely to be involved in AECB. These agents can be administered once daily, making patient compliance and a successful therapeutic outcome more likely. The new quinolones offer promising alternatives for antimicrobial therapy in outpatients with AECB, particularly those with underlying co-morbidity and severe obstruction. PMID:10436551

  6. Chronic Bronchitis

    Science.gov (United States)

    ... can increase your walking speed. You can also increase the length of time you walk to 20 minutes, then 25 minutes, then 30 minutes. Ask your doctor for help creating an exercise plan that's right for you. An exercise program called pulmonary rehabilitation may help you improve your ...

  7. Study on the red blood cell immuno-function and relevant cytokines levels in elderly patients with chronic bronchitis

    International Nuclear Information System (INIS)

    Objective: To explore the changes of red blood cell immuno-function and serum IL-4, IL-5, IL-8, IL-10 levels in elderly patients with chronic bronchitis. Methods: The red cell C3b receptor (RBC-C3bR) and red blood cell immune complex rosette (RBC-ICR) (with immune methods), IL-4, IL-8 levels (with RIA) and IL-10, IL-5 levels (with ELISA) were measured were measured in 48 elderly patients with chronic bronchitis and 35 controls. Results: RBC-C3bRR percentage and IL-10 levels were significantly lower in patients with chronic bronchitis than those in controls (P<0.01) while IL-4, IL-5, IL-8 levels were significantly higher (P<0.01), RBC-C3bRR was significantly negatively correlated to IL-4, IL-5 and IL-8 (r=-0.3112, -0.3415, -0. 3718, P<0.05) and RBC-ICRRR was positiviely correlated to IL-10 level (r=0.3715,P<0.05). Conclusion: The lower red cell immuno-function is closely associated with alteration of cytokines levels in elderly patients with chronic bronchitis. (authors)

  8. Pivmecillinam and amoxycillin as combined treatment in purulent exacerbations of chronic bronchitis.

    Science.gov (United States)

    Pines, A; Nandi, A R; Raafat, H; Rahman, M

    1977-07-01

    One hundred and thirty-two patients with purulent exacerbations of chronic bronchitis were randomly allotted to treatment in three groups. They received (a) amoxycillin 250 mg and pivmecillinam 200 mg; or (b) amoxycillin 500 mg; or (c) amoxycillin 500 mg and pivmecillinam 400 mg: three times daily for 10 days. By the 7th day of treatment there was significant improvement over amoxycillin alone for both groups given combined chemotherapy in conversion of sputum to mucoid and in general improvement; at the end of treatment results in patients given the higher doses of both antibiotics were still superior to amoxycillin alone. Patients were observed 2 to 4 weeks later, when those given amoxycillin alone relapsed much more frequently. The three treatments were well tolerated and succeeded equally in clearing potential pathogens from the sputum. Combined treatment may be superior due to synergy against Haemophilus influenzae or to the elimination of beta-lactamase producing organisms and should be investigated further. PMID:330483

  9. Prevalence of Asthma, COPD, and Chronic Bronchitis in Iran: A Systematic Review and Meta-analysis.

    Science.gov (United States)

    Varmaghani, Mehdi; Farzadfar, Farshad; Sharifi, Farshad; Rashidian, Arash; Moin, Mostafa; Moradi-Lakeh, Maziar; Rahimzadeh, Shadi; Saeedi Moghaddam, Sahar; Kebriaeezadeh, Abbas

    2016-04-01

    In this study, we aimed to conduct a meta-analysis on the results of eligible studies to estimate the prevalence of asthma, COPD, and Chronic bronchitis in Iran. International and Iranian databases including PubMed, Scopus, Web of Science, Iranmedex, and scientific information database (SID) were searched for population-based studies that had reported the prevalence of asthma and COPD from 1990 to 2015. We conducted the meta-analysis using metaprop application of Stata statistical software. I-Squared was used for calculating heterogeneity among the studies. To determine causes of heterogeneity, subgroup analysis and meta-regression method were used. Based on the results of random effect method, the overall prevalence of asthma ever was 4.56% (3.76%-5.36%) among men while it was 4.17% (3.42%-4.91%) among women. Pooled prevalence of current asthma was 7.95% while confidence interval changed from 5.85% to 10.06% (men 5.83% (2.75%-8.92%), women 9.13% (3.35%-14.94%)). Also based on the results of random effect model pooled prevalence of chronic bronchitis of five studies was 5.57%. It seems that the total crude prevalence of current asthma in Iran is less than many other countries such as Kuwait, Lebanon, Thailand, Japan, Australia and Germany and is higher than some other countries such as Oman, Pakistan, South Korea, India, China, Taiwan, Indonesia, Spain, Russia, and Greece. On the other hand, Iran is in middle situation in terms of the prevalence current asthma. Our results can fill the information and knowledge gaps about the status of the prevalence of respiratory diseases in Iran. PMID:27090362

  10. Protective effect of a bacterial extract against acute exacerbation in patients with chronic bronchitis accompanied by chronic obstructive pulmonary disease

    Institute of Scientific and Technical Information of China (English)

    李靖; 郑劲平; 袁锦屏; 曾广翘; 钟南山; 林材元

    2004-01-01

    Background Immunostimulating agents made from bacterial extracts represent a class of medications that contains antigens derived from several bacterial strains and their potential ability to prevent bacterial infections results from the stimulation of the nonspecific component of the immune system. The present study investigated the effect of the oral immunostimulant Broncho-Vaxom, which includes material from eight different species of bacteria that are frequently present in the lower respiratory tract, on the frequency and severity of acute exacerbation in patients with chronic bronchitis accompanied by chronic obstructive pulmonary disease (COPD). Methods Ninety patients with chronic bronchitis complicated with COPD were randomly divided into groups A and B. Forty-nine subjects in group A received oral capsules containing 7mg Broncho-Vaxom, while 41 patients in group B received similar placebo capsules. Both groups took one capsule daily for the first 10 days of each month for 3 consecutive months. The frequency of acute exacerbation, symptom scores, and lung function were recorded for the following one year period.Results There was a significant decrease in the incidence, duration, and severity of acute exacerbation, as well as a reduction in the course of antibiotics administered and in the dosage of bronchodilator and mucolytic agent in group A, as compared to group B (P<0.05, respectively). Symptom scores for cough, sputum, dyspnea, as well as symptoms observed upon auscultation of the chest also improved significantly in group A as compared to group B (P<0.05, respectively). The bacterial clearance rate in sputum cultures from patients who received no antibiotics for the first 3 months was also significantly higher in group A compared to group B (P<0.01).Conclusions Orally administered Broncho-Vaxom is associated with a decrease in the incidence of acute exacerbation and a decrease in the need for antibiotics and symptomatic relief medications in patients

  11. Bronchitis and Pneumonia

    Science.gov (United States)

    ... What is the difference between bronchitis and pneumonia? Bronchitis is most often a bacte- rial or viral infection that causes swelling of the tubes (bronchioles) leading to the lungs. Pneumonia is an acute or chronic disease marked by inflammation of the ...

  12. Tracheobronchial clearance and Beta-adrenoceptor stimulation in patients with chronic bronchitis

    International Nuclear Information System (INIS)

    The effect of a β-adrenoceptor stimulating agent, terbutaline, on mucociliary transport in the lungs was studied in 10 patients with chronic bronchitis. Mucociliary transport was studied by having the patients inhale 6μm teflon particles tagged with sup(99m)Tc and by external measurement of the radioactivity in the lungs in the supine position. Terbutaline 0.25 mg and vehicle respectively were given subcutaneously in a cross-over double-blind study. On the average, clearance was slow in the examinations where the patients were given vehicle. Terbutaline produced a marked increase in mucociliary transport in four patients, a smaller increase in one and no effect in the others. Three out of the four patients who showed a marked increase in clearance had less ventilatory impairment than the other seven patients. This may indicate that the mucociliary transport mechanism is less severely damaged in relatively early stages of the disease than in later stages. On the average FEVsub(1.0) deteriorated significantly during the clearance measurements when vehicle was given, but did not change significantly when terbutaline was given. (author)

  13. Bronchial brush biopsies for studies of epithelial inflammation in stable asthma and nonobstructive chronic bronchitis.

    Science.gov (United States)

    Riise, G C; Andersson, B; Ahlstedt, S; Enander, I; Söderberg, M; Löwhagen, O; Larsson, S

    1996-08-01

    Recently, bronchial brush biopsy (BBB) has been introduced as a complimentary method to bronchial forceps biopsy for the study of bronchial epithelial cells. We wanted to determine whether epithelial inflammatory cells in bronchial brush biopsies can reflect mucosal inflammation assessed indirectly by levels of cellular activation markers in bronchial lavage fluid. We studied 15 healthy controls, 11 asthmatics with regular steroid inhalation therapy, 13 asthmatics without steroids, and 10 smokers with nonobstructive chronic bronchitis. Differential counts of epithelial and inflammatory cells were made from the BBB material. Bronchial lavage levels of eosinophil cationic protein (ECP), myeloperoxidase (MPO), tryptase, hyaluronan and interleukin-8 (IL-8) were measured as indirect markers for inflammatory cell activation. We found an increased percentage of eosinophil granulocytes in the BBB from the steroid-untreated asthmatic patients (1.16%) in comparison to the other groups (0.11%, 0.09% and 0.02%, respectively; pairways disease. These changes appear to relate to the degree of inflammatory activity and disease severity in asthma. PMID:8866592

  14. Whether chronic bronchitis is an independent risk factor for cerebral infarction in the elderly 1:1 case paired study

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    BACKGROUND: The inflammatory reaction already becomes an important risk factor of causing acute cerebral infarction; however, the correlation between chronic bronchitis and senile cerebral infarction is still unclear.OBJECTIVE: To study whether the chronic bronchitis is the risk factor for senile cerebral infarction.DESIGN: 1:1 pair, case contrast, and risk factor study.SETTINGS: Department of Respiratory Medicine, Third Hospital of Tangshan; Department of Neurology,Affiliated Hospital of North China Coal Medical College.PARTICIPANTS: A total of 147 patients with acute cerebral infarction who were regarded as case group were selected from Department of Neurology, the Third Hospital of Tangshan from January 2004 to December 2006. All patients met the diagnostic criteria of the Fourth National Cerebrovascular Diseases Meeting. There were 87 males and 60 females, and their ages ranged from 65 to 83 years. Based on 1∶1 pair study, another 147 subjects without cerebrovascular disease were regarded as control group. Except the diseases about infection, there were 73 males and 74 females, and their ages ranged from 62 to 81 years. All subjects provided the confirm consent and agreed with the coordinate experiment.METHODS: ① Questionnaire of risk factor of cerebral infarction was designed to measure the following items: chronic bronchitis, hypertension, diabetes mellitus, hyperlipemia, coronary heart disease, primary cerebral infarction/transient ischemic attack and history of smoking. ② Cerebral infarction was regarded as the dependent variance, while chronic bronchitis, hypertension, diabetes mellitus, hyperiipemia, primary cerebral infarction/transient ischemic attack, coronary heart disease and smoking were regarded as the independent variance for multiple regression analysis.MAIN OUTCOME MEASURES: Risk factors of senile cerebral infarction.RESULTS: All 147 patients with acute cerebral infarction and 147 subjects without cerebrovascular diseases were involved in

  15. Combined 133Xe/99mTc-HAM lung scan in children with recurrent and chronic bronchitis

    International Nuclear Information System (INIS)

    A total of 117 children with recurrent and chronic bronchitis aged from 2 months to 16 years were subjected to combined ventilation-perfusion scan of the lungs with 133Xe gas and 99mTc-HAM (human albumin microspheres). It served as a screening before bronchological examination with the aim to get a more exact indication for bronchography which leads to a higher stress in children because of anaesthesia and radioscopy. Due to combined lung scan, the number of bronchological examinations could be reduced from 109 in 1984 to 79 in 1985 and even to 54 in 1986. Among the 117 children suffering from bronchitis, normal scans in 16 cases, perfusion defects in 59 cases, combined ventilation-perfusion defects in 41 cases were found and one case showed a pure ventilation defect. The lung scan should be applied in the framework of bronchopulmonary standard diagnosis. (author)

  16. The clinical significance of measurement of TXB2 and 6-K-PGF1α of plasma and broncho-alveolar lavage fluid in patients with bronchial asthma and chronic bronchitis

    International Nuclear Information System (INIS)

    In order to observe the changes in thromboxane B2(TXB2) and 6-keto-prostaglandin F1α(6-K-PGF1α) levels in bronchial asthma, asthmatic chronic bronchitis as well as simple chronic bronchitis, the TXB2 and 6-K-PGF1α levels in plasma and broncho-alveolar lavage fluid (BALF) for control and patients with bronchial asthma, asthmatic chronic bronchitis and simple chronic bronchitis, 30 in each group, were measured by radioimmunoassay. The results showed that the TXB2 and 6-K-PGF1α levels in plasma and BALF in patients of the three groups increased and those in patients with bronchial asthma increased markedly with significant difference, as compared with those in patients with chronic bronchitis (P2 and 6-K-PGF1α levels in BALF in patients with asthmatic chronic bronchitis were much higher than those in patients with simple chronic bronchitis (P2 and 6-K-PGF1α play an important role in pathogenesis of bronchial asthma and asthmatic chronic bronchitis. Consequently, the changes of the two parameters in BALF provide certain reference basis for differential diagnosis of the two types of chronic bronchitis

  17. Diverging trends of chronic bronchitis and smoking habits between 1998 and 2010

    Directory of Open Access Journals (Sweden)

    Accordini Simone

    2013-02-01

    Full Text Available Abstract Background No study has been carried out on the time trend in the prevalence of chronic bronchitis (CB in recent years, despite its clinical and epidemiological relevance. We evaluated the trend in CB prevalence during the past decade among young Italian adults. Methods A screening questionnaire was mailed to general population samples of 20–44 year-old subjects in two cross-sectional surveys: the Italian Study on Asthma in Young Adults (ISAYA (1998/2000; n = 18,873, 9 centres and the screening stage of the Gene Environment Interactions in Respiratory Diseases (GEIRD study (2007/2010; n = 10,494, 7 centres. CB was defined as having cough and phlegm on most days for a minimum of 3 months a year and for at least 2 successive years. The prevalence rates and the risk ratios (RRs for the association between CB and each potential predictor were adjusted for gender, age, season of response, type of contact, cumulative response rate, and centre. Results CB prevalence was 12.5% (95% CI: 12.1-12.9% in 1998/2000 and 12.6% (95% CI: 11.7-13.7% in 2007/2010; it increased among never smokers (from 7.6 to 9.1%, p = 0.003, current light smokers ( Conclusions Despite the significant reduction in current smoking, CB prevalence did not vary among young Italian adults. The temporal pattern of CB prevalence can only be partly explained by the increase of unemployment/premature retirement, asthma and allergic rhinitis, and suggests that other factors could have played a role.

  18. Bronchitis - acute

    Science.gov (United States)

    ... sharing features on this page, please enable JavaScript. Acute bronchitis is swelling and inflammation in the main passages ... present only for a short time. Causes When acute bronchitis occurs, it almost always comes after having a ...

  19. Bronchitis - acute

    Science.gov (United States)

    Acute bronchitis is swelling and inflammation in the main passages that carry air to the lungs. The swelling narrows ... makes it harder to breathe. Another symptom of bronchitis is a cough. Acute means the symptoms have ...

  20. Clinical significance of determination of changes of serum SOD, TNF, CRP levels and T-cell subsets distribution type after treatment in aged patients with chronic bronchitis

    International Nuclear Information System (INIS)

    Objective: To investigate the changes of serum SOD, TNF, CRP levels and T-cell subsets distribution type after treatment in aged patients with chronic bronchitis. Methods: Serum SOD, TNF levels (with RIA), CRP levels (with biochemistry) and T-cell subsets distribution type (with monoclonal antibody) were detected both before and after treatment in 42 aged patients with chronic bronchitis as well as in 35 controls. Results: Before treatment, the serum levels of SOD, CD4/CD8 ratios were significantly lower and serum TNF, CRP levels significantly higher in the patients than those in the controls (P4/CD8 ratios remained significantly higher than those in controls (P <0.05). Conclusion: Determination of serum SOD, TNF, CRP levels and T-cell subsets distribution type is clinically meaningful in aged patients with chronic bronchitis. (authors)

  1. [The rehabilitation under alpine conditions of the participants in the cleanup of the accident at the Chernobyl Atomic Electric Power Station who are ill with chronic bronchitis].

    Science.gov (United States)

    Brimkulov, N N; Abdulina, A A; Davletalieva, N E; Bakirova, A N; Karamuratov, A; Mirrakhimov, M M

    1996-01-01

    24 patients exposed to low-dose radiation after the Chernobyl accident were examined before and after 24-day treatment of chronic bronchitis in the high-altitude rehabilitation center (3200 m above the sea level) in Tien Shan. Sanogenic alpine climate improved the patients' general condition, physical performance and lung ventilation, corrected compromised immunity. After high-altitude adaptation tracheobronchial inflammation alleviated, cytologic composition and surface activity of bronchoalveolar fluid returned to normal. Therefore, high-altitude treatment of Chernobyl accident victims with chronic bronchitis is effective and can be recommended for such patients. PMID:8744100

  2. Current asthma contributes as much as smoking to chronic bronchitis in middle age: a prospective population-based study

    Directory of Open Access Journals (Sweden)

    Dharmage SC

    2016-08-01

    Full Text Available Shyamali C Dharmage,1 Jennifer L Perret,1,2, John A Burgess,1 Caroline J Lodge,1 David P Johns,3 Paul S Thomas,4 Graham G Giles,1,5 John L Hopper,1,6 Michael J Abramson,7,8 E Haydn Walters,3,9, Melanie C Matheson1 1Allergy and Lung Health Unit, Center for Epidemiology and Biostatistics, The University of Melbourne, 2Institute for Breathing and Sleep (IBAS, Melbourne, VIC, 3“Breathe Well” Center of Research Excellence for Chronic Respiratory Disease and Lung Ageing, School of Medicine, University of Tasmania, Hobart, TAS, 4Inflammation and Infection Research, Faculty of Medicine, University of New South Wales, Sydney, NSW, 5Cancer Epidemiology Center, Cancer Council Victoria, Melbourne, VIC, Australia; 6Department of Public Health, Seoul National University, Seoul, South Korea; 7Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, 8School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 9School of Medicine, University of Tasmania, Hobart, TAS, Australia Background and objective: Personal smoking is widely regarded to be the primary cause of chronic bronchitis (CB in adults, but with limited knowledge of contributions by other factors, including current asthma. We aimed to estimate the independent and relative contributions to adult CB from other potential influences spanning childhood to middle age.Methods: The population-based Tasmanian Longitudinal Health Study cohort, people born in 1961, completed respiratory questionnaires and spirometry in 1968 (n=8,583. Thirty-seven years later, in 2004, two-thirds responded to a detailed postal survey (n=5,729, from which the presence of CB was established in middle age. A subsample (n=1,389 underwent postbronchodilator spirometry between 2006 and 2008 for the assessment of chronic airflow limitation, from which nonobstructive and obstructive CB were defined. Multivariable and multinomial logistic regression models were used to estimate

  3. Plastic bronchitis

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    Anil Kumar Singhi

    2015-01-01

    Full Text Available Plastic bronchitis, a rare but serious clinical condition, commonly seen after Fontan surgeries in children, may be a manifestation of suboptimal adaptation to the cavopulmonary circulation with unfavorable hemodynamics. They are ominous with poor prognosis. Sometimes, infection or airway reactivity may provoke cast bronchitis as a two-step insult on a vulnerable vascular bed. In such instances, aggressive management leads to longer survival. This report of cast bronchitis discusses its current understanding.

  4. Plastic bronchitis

    OpenAIRE

    Anil Kumar Singhi; Bharathi Vinoth; Sarah Kuruvilla; Kothandam Sivakumar

    2015-01-01

    Plastic bronchitis, a rare but serious clinical condition, commonly seen after Fontan surgeries in children, may be a manifestation of suboptimal adaptation to the cavopulmonary circulation with unfavorable hemodynamics. They are ominous with poor prognosis. Sometimes, infection or airway reactivity may provoke cast bronchitis as a two-step insult on a vulnerable vascular bed. In such instances, aggressive management leads to longer survival. This report of cast bronchitis discusses its curre...

  5. Efficacy and safety of moxifloxacin in acute exacerbations of chronic bronchitis: a prospective, multicenter, observational study (AVANTI

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    Chuchalin Alexander

    2013-01-01

    Full Text Available Abstract Background Acute exacerbations of chronic bronchitis (AECB, including chronic obstructive pulmonary disease (AECOPD, represent a substantial patient burden. Few data exist on outpatient antibiotic management for AECB/AECOPD in Eastern/South Eastern Europe, in particular on the use of moxifloxacin (Avelox®, although moxifloxacin is widely approved in this region based on evidence from international clinical studies. Methods AVANTI (AVelox® in Acute Exacerbations of chroNic bronchiTIs was a prospective, observational study conducted in eight Eastern European countries in patients > 35 years with AECB/AECOPD to whom moxifloxacin was prescribed. In addition to safety and efficacy outcomes, data on risk factors and the impact of exacerbation on daily life were collected. Results In the efficacy population (N = 2536, chronic bronchitis had been prevalent for > 10 years in 31.4% of patients and 66.0% of patients had concomitant COPD. Almost half the patients had never smoked, in contrast to data from Western Europe and the USA, where only one-quarter of COPD patients are non-smokers. The mean number of exacerbations in the last 12 months was 2.7 and 26.3% of patients had been hospitalized at least once for exacerbation. Physician compliance with the recommended moxifloxacin dose (400 mg once daily was 99.6%. The mean duration of moxifloxacin therapy for the current exacerbation (Anthonisen type I or II in 83.1%; predominantly type I was 6.4 ± 1.9 days. Symptom improvement was reported after a mean of 3.4 ± 1.4 days. After 5 days, 93.2% of patients reported improvement and, in total, 93.5% of patients were symptom-free after 10 days. In the safety population (N = 2672, 57 (2.3% patients had treatment-emergent adverse events (TEAEs and 4 (0.15% had serious TEAEs; no deaths occurred. These results are in line with the known safety profile of moxifloxacin. Conclusions A significant number of patients in this

  6. Clinical efficacy of farcosolvin syrup (ambroxol–theophylline–guaiphenesin mixture in the treatment of acute exacerbation of chronic bronchitis

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    Mostafa Yakoot

    2010-07-01

    Full Text Available Mostafa Yakoot1, Amel Salem2, Abdel-Mohsen Omar31Green Clinics and Research Center, Alexandria, Egypt; 2Al-Mabarah Hospital, 3Faculty of Pharmacy, Alexandria University, Alexandria, EgyptBackground: Acute exacerbations of chronic bronchitis (AECB are defined as recurrent attacks of worsening bronchial inflammation that are marked by an increase in the volume of daily sputum produced, a change in color of the expectorated sputum, and worsening dyspnea. Farcosolvin® (Pharco Pharmaceuticals, Alexandria, Egypt is a mixture of ambroxol (15 mg; theophylline (50 mg; and guaiphenesin (30 mg, per 5 mL syrup.Objective: To test the clinical efficacy of Farcosolvin in the treatment of AECB in a randomized, single-blinded, controlled study design.Patients and methods: One hundred patients with AECB were randomized to either Farcosolvin or guaiphenesin treatment groups, in addition to the standard medical treatment for their cases. Baseline clinical symptomatolgy of breathlessness, cough, and sputum severity scoring were compared before and after 3 and 7 days of treatment in both groups and the differences compared between groups. Changes in perceived improvement were also compared between groups using the Clinical Global Impression of Improvement or Change Scale (CGIC.Results: There were statistically significant improvements in breathlessness and cough scores in both groups (pretreatment versus posttreatment at day 3 and at day 7; P < 0.05. There were highly statistically significant differences between groups in improvement in ­breathlessness and cough scores, after 3 and 7 days treatment, in favor of the Farcosolvin ­treatment group (P < 0.001. Out of 50 patients, 48 (96% in the Farcosolvin-treated group rated their ­improvement on the CGIC scale as “much” and “very much” improved, while only 41 patients (82% reported such a degree of improvement in the control group. The difference was statistically significant (P < 0.05.Conclusion: We

  7. Plastic Bronchitis

    OpenAIRE

    Quysner, Annie; Surani, Salim; Roberts, Daniel

    2011-01-01

    Plastic bronchitis is not yet well understood. There have been less than 500 reported cases in adults worldwide. This patient presented with a one month history of productive sputum consisting of bronchial casts resulting in a diagnosis of plastic bronchitis. [West J Emerg Med. 2011;12(1):118-119.

  8. Mucociliary clearance in diffuse panbronchiolitis, pulmonary emphysema and chronic bronchitis estimated by aerosol inhalation cine-scintigraphy

    International Nuclear Information System (INIS)

    Aerosol inhalation cine-scintigraphy which is a new method for estimation of mucociliary clearance, was studied in patients with diffuse panbronchiolitis (DPB), pulmonary emphysema (PE), chronic bronchitis (CB) and normal controls. The deposition pattern of inhaled aerosols showed mainly a central pattern in PE, but mainly a peripheral pattern in DPB. According to serial observation of inhaled aerosols by cine-scintigraphy, tracheal transport of aerosol-bolus was in a cephalad direction and moved smoothly in normal controls, but transport was slow, zigzag and sometimes regurgitant in patients with PE and CB. Especially, no transport was observed in patients with DPB. Therefore, the authors considered that DPB had the worst impairment of mucociliary clearance, because of both ciliary abnormality and rheological disorders, in the diseases of respiratory tract. (author)

  9. Comparative effects of dexamethasone and bergenin on chronic bronchitis and their anti-inflammatory mechanisms based on NMR metabolomics.

    Science.gov (United States)

    Ren, Xiaolei; Ma, Shuangshuang; Wang, Juan; Tian, Simin; Fu, Xiaorui; Liu, Xinfeng; Li, Zhongfeng; Zhao, Baosheng; Wang, Xueyong

    2016-05-24

    In order to compare the effect of dexamethasone and bergenin on chronic bronchitis and to reveal their anti-inflammatory mechanisms, (1)H NMR-based metabolomics was performed to explore the potential biomarkers of the disease and study the therapeutic mechanisms of the drugs. In this study, 40 Sprague-Dawley male rats were randomly divided into 4 groups, namely control, model, dexamethasone and bergenin groups, with 10 rats in each group. Except for the control group, rats from the other three groups were exposed to tobacco smoke for 1 h d(-1) for 28 days. During the modeling, dexamethasone (0.2 mg kg(-1)) and bergenin (87 mg kg(-1)) were administered orally to dexamethasone or bergenin rats 3 h after exposure every day. On the other hand, control and model rats were intragastrically administered water. According to the results of morphometric analysis of the airway epithelium and the count of white blood cells in the bronchoalveolar lavage fluid (BALF), dexamethasone and bergenin could suppress the infiltration of inflammatory cells, inhibit the secretion of mucus, and reduce white blood cells in BALF. Serum samples from the rats' orbits were collected every week. The metabolic profiles of sera were analyzed by multivariate statistical analyses, including PCA, PLS-DA and OPLS-DA models, and 18 metabolites were identified. The dynamic fluctuations of these biomarkers in sera from different groups were detected. The results suggested that the anti-inflammatory mechanism of dexamethasone may be associated with BCAA metabolism and glycolysis while bergenin could change BCAA metabolism, glycine, serine and threonine metabolism, and glycolysis to treat chronic bronchitis. PMID:27098339

  10. Bronchitis (acute)

    OpenAIRE

    Wark, Peter

    2008-01-01

    Acute bronchitis, with transient inflammation of the trachea and major bronchi, affects over 40/1000 adults a year in the UK. The causes are usually considered to be infective, but only around half of people have identifiable pathogens.The role of smoking or environmental tobacco smoke inhalation in predisposing to acute bronchitis is unclear.A third of people may have longer-term symptoms or recurrence.

  11. Impact of exacerbations on health care cost and resource utilization in chronic obstructive pulmonary disease patients with chronic bronchitis from a predominantly Medicare population

    Directory of Open Access Journals (Sweden)

    Pasquale MK

    2012-11-01

    Full Text Available Margaret K Pasquale,1 Shawn X Sun,2 Frank Song,1 Heather J Hartnett,1 Stephen A Stemkowski11Competitive Health Analytics, Louisville, KY, USA; 2Health Economics and Outcomes Research, Forest Research Institute, Jersey City, NJ, USABackground: Exacerbations of chronic obstructive pulmonary disease (COPD lead to significant increases in resource utilization and cost to the health care system. COPD patients with chronic bronchitis and a history of exacerbations pose an additional burden to the system. This study examined health care utilization and cost among these patients.Methods: For this retrospective analysis, data were extracted from a large national health plan with a predominantly Medicare population. This study involved patients who were aged 40–89 years, had been enrolled continuously for 24 months or more, had at least two separate insurance claims for COPD with chronic bronchitis (International Classification of Diseases, Ninth Revision, Clinical Modification code 491.xx, and had pharmacy claims for COPD maintenance medications between January 1, 2007, and March 31, 2009. Two years of data were examined for each patient; the index date was defined as the first occurrence of COPD. Baseline characteristics were obtained from the first year of data, with health outcomes tracked in the second year. Severe exacerbation was defined by COPD-related hospitalization or death; moderate exacerbation was defined by oral or parenteral corticosteroid use. Adjusted numbers of exacerbations and COPD-related costs per patient were estimated controlling for demographic and clinical characteristics.Results: The final study sample involved 8554 patients; mean age was 70.1 ± 8.6 years and 49.8% of the overall population had exacerbation, 13.9% had a severe exacerbation only, 29.1% had a moderate exacerbation only, and 6.8% had both a severe and moderate exacerbation. COPD-related mean annual costs were $4069 (all figures given in US dollars for the

  12. Chronic obstructive pulmonary disease

    Science.gov (United States)

    ... airways disease; Chronic obstructive lung disease; Chronic bronchitis; Emphysema; Bronchitis - chronic ... a protein called alpha-1 antitrypsin can develop emphysema. Other risk factors for COPD are: Exposure to ...

  13. Traffic-related air pollution associated with prevalence of asthma and COPD/chronic bronchitis. A cross-sectional study in Southern Sweden

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    Nihlén Ulf

    2009-01-01

    Full Text Available Abstract Background There is growing evidence that air pollution from traffic has adverse long-term effects on chronic respiratory disease in children, but there are few studies and more inconclusive results in adults. We examined associations between residential traffic and asthma and COPD in adults in southern Sweden. A postal questionnaire in 2000 (n = 9319, 18–77 years provided disease status, and self-reported exposure to traffic. A Geographical Information System (GIS was used to link geocoded residential addresses to a Swedish road database and an emission database for NOx. Results Living within 100 m of a road with >10 cars/minute (compared with having no heavy road within this distance was associated with prevalence of asthma diagnosis (OR = 1.40, 95% CI = 1.04–1.89, and COPD diagnosis (OR = 1.64, 95%CI = 1.11–2.4, as well as asthma and chronic bronchitis symptoms. Self-reported traffic exposure was associated with asthma diagnosis and COPD diagnosis, and with asthma symptoms. Annual average NOx was associated with COPD diagnosis and symptoms of asthma and chronic bronchitis. Conclusion Living close to traffic was associated with prevalence of asthma diagnosis, COPD diagnosis, and symptoms of asthma and bronchitis. This indicates that traffic-related air pollution has both long-term and short-term effects on chronic respiratory disease in adults, even in a region with overall low levels of air pollution.

  14. ECOLOGICAL STRESS AND ITS EFFECTS ON ESSENTIAL HYPERTENSION AND CHRONIC OBSTRUCTIVE BRONCHITIS DEVELOPMENT IN ROSTOV-ON-DON INHABITANTS

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    L. I. Katelnitskaya

    2015-12-01

    Full Text Available Aim. To study prevalence of essential hypertension (HT and chronic obstructive bronchitis (COB among Rostov-on-Don population, to assess influence of ecological stress on HT and COB development and to find the ways to improve therapy of combined pathology.Material and methods. Single-stage epidemiologic study of Rostov-on-Don population was carried out. The study included questionnaire to reveal main risk factors of chronic noninfectious diseases, a number of laboratory and instrumental indices.Results. Prevalence of HT and COB is significantly higher in patients, living in ecologically unfavorable districts. Rigidity and stretch ability of vascular wall influence the course and development of HT as well as atrial natriuretic factor. Carbonic anhydrase inhibitor, acetazolamide, when is added to standard therapy increases in its efficacy in blood pressure control, decrease in blood pressure in pulmonary artery and correction of disturbed acidbase balance in patients with HT combined with COB.Conclusion. The connection between unfavorable ecology and HT and COB development is demonstrated. Adjuvant therapy with acetazolamide is proposed to increase in efficacy of HT and COB standard therapy.

  15. [Early detection of chronic dust-induced bronchitis in the workers of coal mines in Rostov region].

    Science.gov (United States)

    Zabolotnikova, O D; Piktushanskaia, I N; Kutovoĭ, V I

    1994-01-01

    To diagnose mild forms of dust bronchitis in miners, the medical examination covered pulmonary ventilation parameters. The examination revealed bronchial obstruction, so early stages of bronchitis became 2-2.5 times more frequently diagnosed. Registration of flow-volume curve in forced expiration appeared to be the most productive functional test. PMID:7866714

  16. Clinical significance of measurement of changes of serum IGF-II and NO levels after treatment in elderly patients with chronic bronchitis

    International Nuclear Information System (INIS)

    Objective: To study the clinical significance of changes of serum IGF-II and NO levels after treatment in elderly patients with chronic bronchitis. Methods: Serum IGF-II (with RIA) and NO (with Biochemical method) levels were measured in 42 elderly patients with chronic bronchitis both before and after treatment as well as in 30 controls. Results: Before treatment in the patients the serum IGF-II levels were significantly higher than those in controls (P<0.01), while the NO levels were significantly lower (P<0.01). After two weeks of treatment, the levels though dropped markedly, lemained higher than those in controls (P<0. 05). Conclusion: Serum IGF-II and NO levels changes could reflect the disease status as well as the progress of diseases. (authors)

  17. Cefditoren versus levofloxacin in patients with exacerbations of chronic bronchitis: serum inflammatory biomarkers, clinical efficacy, and microbiological eradication

    Directory of Open Access Journals (Sweden)

    Blasi F

    2013-02-01

    Full Text Available Francesco Blasi, Paolo Tarsia, Marco Mantero, Letizia C Morlacchi, Federico PifferDepartment of Pathophysiology and Transplantation, University of Milan, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Milan, ItalyBackground: The aim of this open-label, randomized, parallel-group pilot study was to evaluate the efficacy of cefditoren pivoxil and levofloxacin in terms of speed of reduction in inflammatory parameters, clinical recovery, and microbiological eradication.Methods: Forty eligible patients with acute exacerbation of chronic bronchitis (AECB were randomized to receive cefditoren 200 mg twice a day for 5 days (n = 20 or levofloxacin 500 mg once daily for 7 days (n = 20.Results: The inflammatory parameters which were significantly reduced at test-of-cure with respect to visit 1 were Krebs von den Lundgen-6 (KL-6 and interleukin-6. KL-6 decreased both in the overall study population (from 19 ± 11 UI/mL to 6 ± 8 UI/mL, P = 0.000 and in the cefditoren (from 19 ± 13 UI/mL to 8 ± 10 UI/mL, P = 0.006 and levofloxacin (from 19 ± 10 UI/mL to 5 ± 5 UI/mL, P = 0.000 arms. Similarly, interleukin-6 decreased both in the overall study population (from 13.35 ± 16.41 pg/mL to 3 ± 4.7 pg/mL, P = 0.000 and in the cefditoren (from 15.90 ± 19.54 pg/mL to 4.13 ± 6.42 pg/mL, P = 0.015 and levofloxacin (from 10.80 ± 12.55 pg/mL to 1.87 ± 1.16 pg/mL, P = 0.003 arms. At the end of treatment (test-of-cure, 6–9 days after drug initiation, the clinical success rate in the overall study population was 78%; the clinical cure rate was 80% in the cefditoren arm and 75% in the levofloxacin arm. Globally, bacteriological eradication at test-of-cure was obtained in 85% of the overall study population. Both treatments were well tolerated.Conclusion: Cefditoren represents a valid option in the treatment of mild to moderately severe cases of AECB in the outpatient care setting. Moreover, the use of this cephalosporin is associated with a significant

  18. Aclidinium bromide inhalation powder for the long-term, maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease including chronic bronchitis and emphysema.

    Science.gov (United States)

    Matera, Maria Gabriella; Sanduzzi, Alessandro; Alfano, Roberto; Cazzola, Mario

    2016-06-01

    Aclidinium is a twice-daily long-acting muscarinic receptor antagonist (LAMA) with an interesting pharmacological profile. Recent evidence indicates that this LAMA, in addition to causing a significant improvement in lung function and other important supportive outcomes, such as health related quality of life, dyspnea and nighttime/early morning symptoms in patients suffering from COPD, is also able to significantly reduce the rate of exacerbations of any severity, is extremely effective in controlling the COPD symptoms, is able to reduce lung hyperinflation, and has an excellent cardiovascular safety profile. Consequently, aclidinium should be considered a first-line approach at least for the symptomatic treatment of COPD although there are still few head-to-head studies comparing this LAMA with other bronchodilators. In any case, aclidinium can be taken into account in the treatment of different COPD phenotypes (emphysema, chronic bronchitis, exacerbators and patients with overlap COPD asthma). PMID:26998725

  19. Ambient temperature and outpatient visits for acute exacerbation of chronic bronchitis in Shanghai: a time series analysis.

    Science.gov (United States)

    Huang, Fang; Zhao, Ang; Chen, Ren Jie; Kan, Hai Dong; Kuang, Xing Ya

    2015-01-01

    The association between ambient temperature and acute exacerbation of chronic bronchitis (AECB) was still unknown. Therefore, we performed an epidemiological study in a large hospital of Shanghai to explore the relationship about temperature and outpatient visit for AECB. We adopted a quasi-Poisson generalized additive models and distributed lag nonlinear models to estimate the accumulative effects of temperature on AECB across multiple days. We found significant non-linear effects of cold temperature on hospital visits for AECB, and the potential effect of cold temperature might last more than 2 weeks. The relative risks of extreme cold (first percentiles of temperature throughout the study period) and cold (10th percentile of temperature) temperature over lags 0-14 d were 2.98 [95% confidence intervals (CI): 1.77, 5.04] and 1.63 (95% CI: 1.21, 2.19), compared with the 25th percentile of temperature. However, we found no positive association between hospital visits and hot weather. This study showed that exposure to both extreme cold and cold temperatures were associated with increased outpatient visits for AECB in a large hospital of Shanghai. PMID:25566865

  20. Clinical Features of Eosinophilic Bronchitis

    OpenAIRE

    Joo, Jae Hak; Park, Sang Joon; Park, Sung Woo; Lee, June Hyuk; Kim, Do Jin; Uh, Soo Taek; Kim, Yong Hoon; Park, Choon Sik

    2002-01-01

    Background Eosinophilic inflammation of the airway is usually associated with airway hyper-responsiveness in bronchial asthma. However, there is a small group of patients which has the eosinophilic inflammation in the bronchial tree with normal spirometry and no evidence of airway hyper-responsiveness, which was named eosinophilic bronchitis. The objectives of this study are 1) to investigate the incidence of eosinophilic bronchitis in the chronic cough syndrome and 2) to evaluate the clinica...

  1. Contrasting geographical distribution of mortality from pneumoconiosis and chronic bronchitis and emphysema in British coal miners.

    OpenAIRE

    Coggon, D; Inskip, H.; Winter, P; Pannett, B

    1995-01-01

    To explore whether the characteristics of coal mine dust that predispose to chronic airways obstruction are the same as those associated with pneumoconiosis, mortality from the two disease was compared in coal miners in 22 counties of England and Wales during 1979-80 and 1982-90. The proportional mortality ratios (PMRs) for coal workers' pneumoconiosis varied from 135 (95% confidence interval (95% CI) 16-488) in Leicestershire to 3825 (95% CI 1538-7881) in South Glamorgan. The PMRs for chroni...

  2. High-dose oral N-acetylcysteine fails to improve respiratory health status in patients with chronic obstructive pulmonary disease and chronic bronchitis: a randomized, placebo-controlled trial

    Directory of Open Access Journals (Sweden)

    Johnson K

    2016-04-01

    Full Text Available Kara Johnson,1,2 Charlene E McEvoy,3 Sakina Naqvi,1,4 Chris Wendt,1 Ronald A Reilkoff,4,5 Ken M Kunisaki,1 Erin E Wetherbee,1 David Nelson,6 Rabindra Tirouvanziam,7 Dennis E Niewoehner1 1Pulmonary Section, Minneapolis VA Health Care System, Minneapolis, MN, 2Sanford Health, Fargo, ND, 3Pulmonary Section, HealthPartners Research Foundation, St Paul, 4HealthEast Maplewood Clinic, Maplewood, 5Pulmonary Section, University of Minnesota Medical Center, 6Center for Chronic Disease Outcomes Research, Minneapolis VA Health Care System, Minneapolis, MN, 7Center for Cystic Fibrosis and Airways Disease Research, Emory University School of Medicine, Atlanta, GA, USA Background: Clinical outcomes are worse in patients with COPD and chronic bronchitis. N-acetylcysteine (NAC is commonly prescribed for such patients but with uncertain clinical benefits. We postulated that oral NAC, at much larger doses than those ordinarily prescribed, would improve clinical outcomes in a subset of patients with COPD and chronic bronchitis. Objective: The aim of this study was to determine whether very high-dose NAC would improve respiratory health status in patients with COPD and chronic bronchitis. Methods: Patients with COPD and chronic bronchitis were enrolled in a randomized, controlled, double-blinded trial. Patients received oral NAC (1,800 mg or matching placebo twice daily for 8 weeks in addition to their usual respiratory medications. The primary outcome, respiratory health status, was assessed by changes in the St George’s Respiratory Questionnaire. The effects of NAC on lung function and circulating markers of oxidative stress and inflammation were also evaluated. Results: We terminated the study prematurely because new external information suggested the possibility of a safety issue. Of the planned 130 patients, 51 were randomized and 45 (22 in the placebo arm and 23 in the NAC arm completed the study. There was no statistically significant difference between

  3. 崔应珉教授治疗慢性支气管炎经验%Experience of Professor Cui Yingmin in the Treatment of Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    张珂

    2013-01-01

    Objective:To summarize the experience of Professor Cui Yingmin in the treatment of chronic bronchitis. Methods: Based on chronic bronchitis cases treated by Professor Cui Yingmin,to analyze and summarize the dialectical thought and clinical experiences. Results: Professor Cui Yingmin regarded chronic bronchitis was deficiency for the fundamental reason and excess in manifestation, with lung,spleen and kidney for the deficiency,while phlegm and blood stasis as the manifestation. Clinical treatment was acute exacerbation of chronic,with remission and delayed treatment by stage,with the modification of Shegan Mahuang soup,Yuebi Jiazhu soup,Sanzi Yan-gqin soup, Buzhong Yiqi soup, Erchen soup, Shashen Maidong soup. The clinical curative effect was marked. Conclusion: Professor Cui Yingmin argues that chronic bronchitis is an easily relapsed and refractory disease,in clinical it should be treated by stages by taking care of the fundermental causes and manifestations, which provides some clinical reference.%目的:探讨崔应珉教授治疗慢性支气管炎经验.方法:以崔应珉教授治疗慢性支气管炎验案为依据,分析总结其辨证思路及临证经验.结果:崔应珉教授针对慢性支气管炎多为本虚标实这一特点,以肺、脾、肾三脏亏虚为本,痰浊、瘀血为标,临床施治多以急性加重期、慢性缓解期与迁延期分期论治,以射干麻黄汤、越婢加术汤、三子养亲汤、补中益气汤、二陈汤、沙参麦冬汤等灵活化裁,临床疗效显著.结论:崔应珉教授认为慢性支气管炎是一种易复发难治性疾病,临床采用分期辨治,标本兼顾,可资临床参考.

  4. Otras enfermedades obstructivas: bisinosis, bronquitis crónica y EPOC de origen laboral y bronquitis eosinofílica Other obstructive diseases: byssinosis, chronic bronchitis and occupational COPD and eosinophilic bronchitis

    Directory of Open Access Journals (Sweden)

    F. J. Michel De la Rosa

    2005-01-01

    Full Text Available Además del asma ocupacional y las enfermedades derivadas de la inhalación aguda, otras enfermedades obstructivas también reconocen un origen laboral. Aunque en la actualidad la bisinosis es una enfermedad rara en España, describimos las características de la misma por su interés histórico dentro de las enfermedades respiratorias de origen laboral y porque todavía sigue vigente en los países en vías de desarrollo. La bronquitis crónica también puede estar relacionada con la exposición laboral a polvos y humos, con frecuencia denominada "bronquitis industrial". La relación ocupacional de la EPOC ha sido más controvertida a lo largo de la historia, pero en la actualidad esta relación está aceptada; describimos la evidencia actual que sustenta esta relación. En último lugar, describimos la bronquitis eosinofílica sin asma, entidad descrita por primera vez en 1989 y que en ocasiones también puede tener un origen laboral, compartiendo agentes etiológicos con el asma ocupacional.Besides occupational asthma and diseases derived from acute inhalation, other obstructive diseases also have an occupational origin. Although at present byssinosis is a rare disease in Spain, we describe its characteristics because of its historical interest amongst occupational respiratory diseases and because it is still relevant in developing countries. Chronic bronchitis can also be related to exposure at work to dust and smoke, and is often referred to as "industrial bronchitis". Historically, the relation of CPOD to occupation has been subject to controversy, but nowadays this relationship is accepted; we describe the present evidence supporting this relationship. Finally, we describe eosinophilic bronchitis without asthma, an entity that was described for the first time in 1989 and that can sometimes have an occupational origin, sharing aetiological agents with occupational asthma.

  5. Hyperbaric oxygenation in the complex treatment of obstructive chronic bronchitis in patients - participants in the liquidation of Chernobyl NPP accident consequences

    International Nuclear Information System (INIS)

    Hyperbaric oxygen therapy it has been used in the program of complex treatment at 30 patients with a chronic obstructive bronchitis. The rate hyperbaric oxygen therapy has consisted of 8-10-12 sessions, depending on weight of disease and a condition of the patient. As a result of treatment with use hyperbaric oxygen therapy/ fast improvement is reached clinical condition, positive dynamics of a gas condition of arterial blood and improvement of functional parameters of pulmonary ventilations and central hemodynamics of patients and also anti-oxidant protection activity were revealed in the basic group. (authors)

  6. 135例慢性支气管炎急性发作的护理%Nursing Care of 135 Cases With Acute Exacerbation of Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    苏艳镁; 张英

    2016-01-01

    Objective To investigate the nursing methods of chronic bronchial acute attack.Methods Selected 135 patients with acute exacerbation of chronic bronchitis from January 2013 to December 2014 in our hospital, given the comprehensive nursing intervention. Results The effective rate of the treatment of patients with disease was 94.8%, and the satisfaction of nursing satisfaction was 100%.Conclusion It’s important to carry out comprehensive nursing intervention for patients with acute exacerbation of chronic bronchitis, which can effectively improve the patient's condition.%目的:对慢性支气管急性发作的护理方法予以探讨。方法随机选取我院2013年1月~2014年12月接收的慢性支气管炎急性发作期患者135例,针对患者的实际特点,积极为患者开展综合护理干预。结果患者治疗有效率达94.8%,护理满意度调查中显示,护理满意度为100%。结论积极为慢性支气管炎急性发作期患者开展综合护理干预,能够有效的改善患者的病情。

  7. 自拟咳嗽方治疗急慢性支气管炎200例疗效观察%The effect of self cough decoction in the treatment of acute,chronic bronchitis in 200 cases

    Institute of Scientific and Technical Information of China (English)

    鲜晓燕; 张鲁燕

    2014-01-01

    Objective:To observe the curative effect of self cough decoction add and subtract in the treatment of acute and chronic bronchitis.Methods:200 cases of patients with acute and chronic bronchitis were used self cough decoction add and subtract treatment.Results:The total effective rate was 100%.Conclusion:The curative effect of self cough decoction in the treatment of acute and chronic bronchitis is satisfactory.%目的:观察自拟止咳方加减治疗急慢性支气管炎的疗效。方法:对200例急慢性支气管炎患者采用自拟止咳方加减治疗。结果:总有效率100%。结论:自拟止咳方治疗急慢性支气管炎疗效满意。

  8. Exposure to cold and draught, alcohol consumption, and the NS-phenotype are associated with chronic bronchitis: an epidemiological investigation of 3387 men aged 53-75 years: the Copenhagen Male Study

    OpenAIRE

    Suadicani, P; Hein, H.; H. Meyer; Gyntelberg, F

    2001-01-01

    OBJECTIVES—This study was performed to estimate the strength of association between chronic bronchitis and lifetime exposure to occupational factors, current lifestyle, and the NS-phenotype in the MNS blood group among middle aged and elderly men.
METHODS—The study was carried out within the frameworks of the Copenhagen Male Study. Of 3387 men 3331 men with a mean age of 63 (range 53-75) years could be classified by prevalence of chronic bronchitis. As well as the completion of a large questi...

  9. The measuring of the resorptive clearance of inhaled 99m technetium pertechnetate in normal persons and in patients with chronically obstructive bronchitis and with lung fibrosis

    International Nuclear Information System (INIS)

    On 32 patients with lung fibrosis of various genesis, chronically obstructive bronchitis and carcinomas the resorptive clearance of the lung in comparison to 12 normal persons was carried out, specifically with a 99mTc-pertechnate aerosol in an atomiser (particle diameter of < 1 μm) doing inspiring vital capacity manuveurs. Patients with chronically obstructive bronchitis and lung fibrosis showed a clearance which slowed down in the middle, carcinoma patients showed a strongly slowed resorptive clearance in the diseased areas. A comparison with spirometric data and gas exchange parameters brought merely for MMEF a weakly significant correlation. A decisive influence of the condition of the bronchial mucous membrane on the result of the resorptive clearance was ascertained. Pollutants remain with decreased clearance longer in the lung and could possibly increase a predisposition to cancer. By the measuring of the resorptive clearance it can at least be determined which people were exposed for longer times to the damaging effects of such materials. (TRV)

  10. Diagnosing and Treating Acute Bronchitis

    Science.gov (United States)

    ... Lung Disease Lookup > Acute Bronchitis Diagnosing and Treating Acute Bronchitis It is important to get your questions about ... Symptoms that last a few weeks How Is Acute Bronchitis Diagnosed? Healthcare providers diagnose acute bronchitis by asking ...

  11. 盐酸美西律治疗慢性支气管炎临床分析%Clinical Analysis of Mexiletine Hydrochloride Treatment for Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    赵丹

    2013-01-01

    目的:观察盐酸美西律雾化吸入治疗慢性支气管炎急性发作时的临床疗效。方法选取我院收治的56例慢性支气管炎急性发作患者,随机分两组,对照组给予常规治疗,实验组在常规治疗的基础上加盐酸美西律注射液15mg、生理盐水5ml进行雾化吸入治疗。结果对照组总有效率75%,实验组总有效率93%。结论加用盐酸美西律雾化吸入治疗有利于缩短病程,值得推广应用。%Objective To observe the clinical ef icacy of mexiletine hydrochloride inhalation in treatment of acute exacerbations of chronic bronchitis. Methods:in our hospital treated 56 cases of acute exacerbations of chronic bronchitis, were randomly divided into two groups, the control group was given conventional treatment, the experimental group on the basis of conventional therapy plus mexiletine hydrochloride injection 15mg, saline inhalation of 5ml treatment. Results:the total ef ective rate of the control group 75%, the experimental group, the total ef iciency of 93%. Conclusion: combined with mexiletine hydrochloride inhalation therapy can shorten the course of disease, it is worthy of popularization and application.

  12. How Is Bronchitis Treated?

    Science.gov (United States)

    ... symptoms and make breathing easier. If you have acute bronchitis, your doctor may recommend rest, plenty of fluids, ... treat fever. Antibiotics usually aren't prescribed for acute bronchitis. This is because they don't work against ...

  13. 溴己新治疗慢性支气管炎的疗效评价%Curative effect evaluation of bromhexine for the treatment of chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    邓梓辛; 张美祥; 谭璐; 汪曲; 王树平

    2015-01-01

    Objective To assess the effect and safety of bromhexine for chronic bronchitis .Methods We retrieve the database inclu‐ding PubMed ,the Cochrane library ,China National Knowledge Internet (CNKI) ,Weip Database (VIP) and Wanfang Data . Eight randomized controlled trials (RCT ) comparing bromhexine with ambroxol ,Erchentang ,Kechuanning oral liquid ,S‐carboxy‐methylcysteine and placebo were included in this research .The course of treatment was more than 5 days .The Jadad quality tools was used for the quality evaluation of each study .Results There were 4 RCTs which compared bromhexine with ambroxol ,with significant difference in clinical overall efficacy [RR=0 .83 ,95% CI(0 .76 ,0 .91) ,P<0 .000 1] .The rest groups required descrip‐tive analysis for study quantity .Conclusion Chronic bronchitis can be treated effectively by bromhexine .However ,compared with ambroxol ,the result of quality grade and Meta‐analysis reveals lower curative effect .%目的:评价溴己新治疗慢性支气管炎的疗效及安全性。方法通过检索PubMed、Cochrane library、中国期刊全文数据库(China National Knowledge Internet ,CNKI)、维普数据库(Weip Database ,VIP)和万方数字化期刊全文数据库;纳入随机对照试验(Randomized Controlled Trial ,RCT)8篇,包括溴己新对比氨溴索、二陈汤、咳喘宁口服液、S‐羧甲半胱氨酸和安慰剂组;利用Jadad质量评分工具进行方法质量评价。结果溴己新组对比氨溴索组共4个RC T ,临床总有效率比较:R R=0.83,95% C I (0.76,0.91),P<0.0001,差异有统计学意义。其余组由于文献数量少限制而进行描述性分析。结论溴己新可以有效地治疗慢性支气管炎,但是质量评分以及Meta分析显示其疗效低于氨溴索。

  14. Gemifloxacin for the treatment of community-acquired pneumonia and acute exacerbation of chronic bronchitis: a meta-analysis of randomized controlled trials

    Institute of Scientific and Technical Information of China (English)

    ZHANG Lei; WANG Rui; Falagas E. Matthew; CHEN Liang-an; LIU You-ning

    2012-01-01

    Background Gemifloxacin is a fluoroquinolone antibiotic with broad spectrum of antibacterial activity.The aim of the study was to evaluate the comparative effectiveness and safety of gemifloxacin for the treatment of patients with community-acquired pneumonia (CAP) or acute exacerbation of chronic bronchitis (AECB).Methods We performed a meta-analysis of randomized controlled trials (RCTs) comparing gemifloxacin with other approved antibiotics.The PubMed,EMBASE,Chinese Biomedical Literature Database and the Cochrane Central Register of Controlled Trials were searched,with no language restrictions.Results Ten RCTs,comparing gemifloxacin with other quinolones (in 5 RCTs) and β-lactams and/or macrolides (in 5 RCTs),involving 3940 patients,were included in this meta-analysis.Overall,the treatment success was higher for gemifloxacin when compared with other antibiotics (odds ratio 1.39,95% confidence interval 1.15-1.68 in intention-to-treat patients,and 1.33,1.02-1.73 in clinically evaluable patients).There was no significant difference between the compared antibiotics regarding microbiological success (1.19,0.84-1.68) or all-cause mortality (0.82,0.41-1.63).The total drug related adverse events were similar for gemifloxacin when compared with other quinolones (0.89,0.56-1.41),while lower when compared with β-lactams and/or macrolides (0.71,0.57-0.89).In subgroup analyses,administration of gemifloxacin was associated with fewer cases of diarrhoea and more rashes compared with other antibiotics (0.66,0.48-0.91,and 2.36,1.18-4.74,respectively).Conclusions The available evidence suggests that gemifloxacin 320 mg oral daily is equivalent or superior to other approved antibiotics in effectiveness and safety for CAP and AECB.The development of rash represents potential limitation of gemifloxacin.

  15. Analysis the Clinical Value of Ambroxol Hydrochloride in Acute Exacerbation of Chronic Bronchitis%盐酸氨溴索在慢性支气管炎急性加重期的临床价值分析

    Institute of Scientific and Technical Information of China (English)

    张美艳

    2015-01-01

    Objective To investigate the application value of ambroxol hydrochloride in acute exacerbation of chronic bronchitis.Methods84 cases of chronic bronchitis in acute exacerbation stage were divided into study group (conventional therapy plus ambroxol hydrochloride) and control group (conventional therapy),according to with the hospitalization sequence.Results The total effective rate of the study group was significantly higher than that of the control group, the two group had significant difference (P<0.05); The incidence of adverse reaction in the study group was significantly lower than that in the control group (P<0.05).Conclusion Ambroxol in chronic bronchitis acute exacerbation has a high application value.%目的:探讨盐酸氨溴索在慢性支气管炎急性加重期的应用价值。方法将84例慢性支气管炎急性加重期患者按照住院先后顺序分为研究组(常规治疗+盐酸氨溴索)与对照组(常规治疗)。结果研究组患者治疗总有效率明显高于对照组,二者有显著性差异(P<0.05);研究组不良反应发生率明显低于对照组(P<0.05)。结论盐酸氨溴索在慢性支气管炎急性加重期有着较高的应用价值。

  16. The Clinical Observation of Hormone in Treatment of Acute Phase of Chronic Bronchitis%激素治疗慢性支气管炎急性期临床观察

    Institute of Scientific and Technical Information of China (English)

    蔡朝敏; 汪传臻

    2013-01-01

      目的:观察激素短疗程治疗慢性支气管炎急性期临床疗效。方法:将93例慢性支气管炎急性发作期患者随机分为治疗组48例,对照组45例,对照组予常规抗感染、解痉平喘、吸氧等对症及支持治疗,治疗组在对照组治疗基础上短期加用激素治疗,观察临床疗效。结果:治疗组临床疗效明显高于对照组。结论:激素短程治疗慢性支气管炎急性期疗效显著,可作为首选治疗。%Objective:To observe the clinical effect of short course of glucocorticoid in treatment of acute phase of chronic bronchitis.Methods:93 cases of patients with acute phase of chronic bronchitis were randomly divided into a treatment group of 48 cases,45 cases in the control group,the control group received routine anti-infection,spasmolysis,oxygen and other symptomatic and supportive treatment,the treatment group on the basis of the control group treated with short-term hormone therapy,the clinical effect was observed.Results:The clinical effect of treatment group was significantly higher than the control group. Conclusion:The effect of short-term hormone in treatment of chronic bronchitis in acute phase is good,it can be used as the preferred treatment.

  17. Clinical Observation on Qingfei Huatan Granula in Treating 129 Acute Tracheal Bronchitis or Chronic Bronchitis Patients%“清肺化痰颗粒”治疗急性气管—支气管炎及慢性支气管炎急性发作129例临床观察

    Institute of Scientific and Technical Information of China (English)

    张前进; 吕凤霞; 王华; 王丽勤

    2011-01-01

    [Objective] The aim of this study is to investigate the effects of Qingfei Huatan Granula on the 129 patients suffering from acute tracheal bronchitis or chronic bronchitis. [Methods] 129 patients were divided randomly into treatment group and control group. Qingfei Huatan Granula was given to the patients of treatment group. LingYang QingFei Pills was given to the patients of control group. Therapeutic evaluation was based on recovery of a cough and sputum. [Results] The curative effect of Qingfei Huatan Granula on the acute stage of chronic bronchitis showed that the clinical total effective rate was 84.4%,the rate of cough 87.5% and the rate of sputum 89.1%. The curative effect of LingYang QingFei Pills on the acute stage of chronic bronchitis showed that the clinical total effective rate was 81.6%,of cough 81.6% and of sputum 78.9%. The curative effect on sputum in the trial group was more significant. The curative effect of Qingfei Huatan Granula on acute tracheobronchitis showed that the clinical total effective rate was 89.2% , of cough and sputum 89.2%. The curative effect of LingYang QingFei Pills on acute tracheobronchitis showed that the clinical total effective rate was 84.4% , the rate of cough 84.4% and the rate of sputum 81.3%. The curative effect on comprehensive therapeutic efficacy and sputum in the trial group was more significant. [Conclusions] The curative effect of Qingfei Huatan Granula was better than that of LingYang QingFei Pills in comprehensive therapeutic efficacy and relief of cough and sputum of two diseases. The curative effect on comprehensive therapeutic efficacy and sputum of acute tracheobronchitis and on sputum of the acute stage of chronic bronchitis in the trial group was significant.%[目的]观察“清肺化痰颗粒”对急性气管—支气管炎及慢性支气管炎急性发作的疗效.[方法]将199例观察对象随机分为两组,治疗组129例给予“清肺化痰颗粒”,3次/d,每次1袋,1周为1个疗程;对

  18. An effective analysis of acupoint sticking therapy on prevention of acute chronic bronchitis%穴位贴敷疗法在慢性支气管炎急性发作预防中的疗效分析

    Institute of Scientific and Technical Information of China (English)

    李健瑜; 陈文杰

    2012-01-01

      Objective: To application of acupoint sticking therapy for prevention of chronic bronchitis patients with symptoms of acute clinical effect analysis. Methods: Selected 78 cases suffering from chronic bronchitis patients case, will be divided into control group and treatment group, 39 cases in each group the average. Patients in the control group using conventional antibiotic therapy; patients in the treatment group routine antibiotic therapy combined with acupoint sticking therapy. Results: The treatment group of patients with symptoms of chronic bronchitis curative effect obviously surpasses the comparison group; treatment after a period of illness acute seizures were fewer than those in control group. Conclusion: The application of acupoint sticking therapy for prevention of chronic bronchitis patients with symptoms of acute onset of clinical effect is very obvious.%  目的:对应用穴位贴敷疗法预防慢性支气管炎患者症状急性发作的临床效果进行研究分析。方法:抽取78例患有慢性支气管炎的患者病例,将其分为对照组和治疗组,平均每组39例。对照组患者采用常规抗生素治疗;治疗组患者在常规抗生素治疗基础上加用穴位贴敷疗法进行治疗。结果:治疗组患者慢性支气管炎症状治疗效果明显优于对照组;治疗后一段时间内病情急性发作人数明显少于对照组。结论:应用穴位贴敷疗法预防慢性支气管炎患者症状急性发作的临床效果非常明显。

  19. Dyspnea and Wheezing after Adenosine Injection in a Patient with Eosinophilic Bronchitis

    OpenAIRE

    Kaiser Lim; Marie Christine Aubry; Rodrigo Cartin-Ceba

    2009-01-01

    A 58-year-old nonsmoker female was referred for evaluation of chronic cough of 13 months duration. After an initial work-up, the patient was diagnosed to have chronic cough due to eosinophilic bronchitis. The diagnostic work-up for eosinophilic bronchitis and bronchial biopsy is discussed. Eosinophilic bronchitis is differentiated from asthma. In addition, the patient developed dyspnea, flushing, and wheezing after the administration of adenosine during a cardiac stress test in spite of a neg...

  20. Causes of acute bronchitis (image)

    Science.gov (United States)

    ... the respiratory system that leads into the lungs. Acute bronchitis has a sudden onset and usually appears after ... and the production of thick yellow mucus. If acute bronchitis occurs because of a bacterial infection antibiotics are ...

  1. Greatest International ANtiinfective Trial (GIANT with moxifloxacin in the treatment of acute exacerbation of  chronic bronchitis: subanalysis of Chinese data of a global, multicenter, noninterventional study

    Directory of Open Access Journals (Sweden)

    Yulin Feng

    2010-03-01

    Full Text Available Yulin Feng1, Faguang Jin2, Shuang Mu3, Hong Shen4, Xiaohong Yang5, Yuling Wang6, Zhenshan Wang7, Yingjun Kong8, Zuke Xiao9, Qiming Feng101Respiratory Department, West China Hospital, Sichuan University, China; 2Respiratory Department, Tang Du Hospital, China; 3Respiratory Department, Peking University People’s Hospital, China; 4Emergency Department, The General Hospital of the People’s Liberation Army, China; 5Respiratory Department, Xinjiang People’s Hospital, China; 6Respiratory Department, Shi Jiazhuang First Hospital, China; 7Respiratory Department, The Second Affiliated Hospital of Dalian Medical University, China; 8Respiratory Department, The First Clinical College of Harbin Medical University, China; 9Respiratory Department, The Jiangxi Provincial People’s Hospital, China; 10Emergency Department, Shanghai Sixth People’s Hospital, ChinaBackground and objective: A single infective acute exacerbation of chronic bronchitis (AECB has a sustained effect on health status. Although a number of clinical investigations have demonstrated the efficacy of antibiotics in AECB, increased bacterial resistance has caused concern about the efficacy of currently available antibiotic therapies. This subanalysis of a global noninterventional study aimed to evaluate the impact of AECB on the patient and the community and the effectiveness and safety of a treatment with moxifloxacin (MXF tablets in daily life clinical practice in China.Methods: This prospective, noninterventional, noncontrolled, multicenter observational study, which started in China in April 2004 and ended in February 2007, was part of the global GIANT study. Patients with a diagnosis of mild to severe AECB were treated with MXF tablets 400 mg for a period at the physician’s discretion. The observation period for each patient covered a complete treatment period with MXF. For each patient, the physician documented data at an initial visit (baseline and at least one follow-up visit

  2. Infectieuze bronchitis bij leghennen

    OpenAIRE

    Wit, de, S.

    1996-01-01

    Het Infectieuze Bronchitis Virus (IB) is een van de meest voorkomende virussen in de pluimveehouderij. Men mag rustig zeggen dat waar kippen gehouden worden, ook het IB virus voorkomt. Infecties met dit virus kunnen bij kippen van alle leeftijden ziekte m

  3. 穴位贴敷配合中药内服治疗慢性支气管炎疗效观察%Curative Effect Observation of Acupoint Sticking Therapy Combined Orally Traditional Chinese Medicine on Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    黎沛环; 吴锡强; 赵晓燕; 宋黎梅; 王冬云

    2015-01-01

    Objective :To observe the curative effect of the treatment of acupoint application combined with orally traditional Chinese medicine on chronic bronchitis. Methods: Selected 60 cases with chronic bronchitis were divided into control group and treatment group randomly ,30 cases in each group the average. The patients in the control group received acupoint application for 6 times a year in the dog days of summer ,the third nine period after the winter solstice in 3 years in a row. And the ones in the treatment group received acupoint application combined with orally traditional Chinese medicine. Results:The recovery rate and total effective rate were higher in treatment group than those in control group. There was a significant difference between the two groups in their therapeutic effect (P<0.05),and curative effect had a tendency to improve with the increase of number of acupoint sticking therapy and orally traditional Chinese medicine. Conclusion: The treatment of acupoint application com-bined with orally traditional Chinese medicine has good and reliable effect on the prevention and cure of chronic bronchitis.%目的:观察穴位贴敷配合中药内服治疗慢性支气管炎的疗效。方法:选取60例患有慢性支气管炎的患者为研究对象,随机分为对照组和观察组,每组30例。对照组在每年三伏、三九天予以穴位贴敷治疗6次,连续3年;观察组在穴位贴敷基础上给予中药内服治疗。结果:观察组临床治愈率及总有效率均高于对照组,两组疗效比较差异显著(P<0.05),并且随穴位贴敷及内服中药次数的增加,疗效有提高的趋势。结论:穴位贴敷配合中药内服对防治慢性支气管炎有良好的作用。

  4. 慢性支气管炎急性发作患者痰病原学及耐药性分析%Sputum pathogens and drug resistance analysis of patients with acute exacerbations of chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    高成兵; 杨伟; 汪平; 幸仕洪; 王珏

    2013-01-01

    Objective Study on acute exacerbation of chronic bronchitis patients and drug resistance of pathogenic data. Methods Respiratory department of our hospital from 2010 January to 2010 December, 623 cases of acute exacerbation of chronic bronchitis treated with routine of sputum pathogenic detection. All experimental strains were API system for bacterial identification , using the disc diffusion method, according to the CLS1 drug sensitive test of antibacterial drug grouping principle. Results Qualified sputum samples were isolated from the strain of 448 strains of Gram-negative bacteria, which accounted for the main, Pseudomonas most 18. 4%. The detection of ESBL enzyme-producing strains of 13 strains of,mainly produced by a Pseudomonassp; MRSA enzyme-producing strain 5, all produced by staphylococcus; Multiple drug resistance of Acinetobacter strains of 8, mainly produced by Bauman acinetobacter. Conclusion Patients with acute exacerbations of chronic bronchitis pathogens in Gram-negative bacteria accounted for a major. The situation is more serious and resistance, clinicians should pay more attention.%目的 研究慢性支气管炎急性发作患者的病原学资料及耐药情况.方法 我院自2010年1月~2010年12月收治623例慢性支气管炎急性发作的患者,常规开展痰液病原学检测,所有实验菌株均以API系统进行细菌鉴定,采用纸片扩散法,按CLSI药敏试验抗菌药物分组原则进行.结果 合格痰液标本共分离出菌株448株,其中革兰氏阴性菌占主要,假单胞菌最多,达18.4%.其中,检出产ESBL酶菌株13株,主要由假单胞菌产生;产MRSA酶5株,全部由葡萄球菌产生;多重耐药不动杆菌8株,主要由鲍曼不动杆菌产生.结论 慢性支气管炎急性发作患者病原菌中革兰氏阴性菌占主要,且耐药情况较为严重,应引起临床高度重视.

  5. Clinical Analysis of ShuLiyi to Treat Chronic Bronchitis Acute Onset%舒利迭治疗慢性支气管炎急性发作的临床分析

    Institute of Scientific and Technical Information of China (English)

    徐亦农

    2013-01-01

    Objective:To investigate the ShuLi idea for treatment of chronic bronchitis acute episodes. Methods:A retrospective analysis from January 2010 to March 2010 were treated 140 cases of patients with chronic bronchitis acute clinical cases, according to random method the 140 patients were divided into treatment group and control group, 70 cases in each group, the treatment group patients on the basis of conventional treatment combined with ShuLi overlapping (salmeterol assigned powder inhalant), control group patients only routine phlegm treatment, compared two groups of patients in the therapeutic effect and adverse reactions. Results:The treatment group patients clinical treatment effect is better than that of control group (P<0.05), statistically significant difference between the two groups of patients. Conclusion:ShuLi overlapping (salmeterol assigned powder inhalant) can be effective for the treatment of chronic bronchitis acute episodes, good safety, small adverse reactions, worthy of popularization and application in clinic.%目的:探讨舒利迭治疗慢性支气管炎急性发作的临床效果。方法:回顾性分析我院2010年1月~2013年3月收治的140例慢性支气管炎急性发作患者的临床病例,按照随机的方法将这140例患者分为治疗组及对照组,每组70例,治疗组患者在常规治疗的基础上加用舒利迭(沙美特罗替卡松粉吸入剂),对照组患者仅行常规化痰治疗,比较两组患者的治疗效果及不良反应。结果:治疗组患者的临床治疗效果优于对照组(P<0.05),两组患者间差异具有统计学意义。结论:舒利迭(沙美特罗替卡松粉吸入剂)可有效的治疗慢性支气管炎急性发作,安全性好,不良反应小,值得在临床上推广应用。

  6. Clinical Observation of Yinqiao Zhisou Powder in Treating Acute Onset of Chronic Bronchitis%银翘止嗽散治疗慢性支气管炎急性发作期临床观察

    Institute of Scientific and Technical Information of China (English)

    汤宏涛

    2012-01-01

    Objective:To observe the clinical efficacy of Yinqiao Zhisou Powder in treating acute onset of chronic bronchitis. Methods;80 cases who were diagnosed as acute onset of chronic bronchitis were given Yinqiao Zhisou Powder ( Composition; honeysuckle 30 g, for-sythia 20 g,the Aster 15 g,Radix Stemonae 15 g,radix cynanchi 10 g,Coltsfoot 10 g,radix scutellariae 10 g,prepared Ephedra 10 g,the Campanulaceae 15 g,licorice 5 g) for treatment with water decoction,one dose per day and 10 d for a course of treatment. All cases were treated for one to two courses. Results;37 cases were cured;28 cases were markedly effective;13 cases were effective;2 cases were ineffective. The effective rate was 97.5%. Conclusion: Yinqiao Zhisou Powder has significant effect in treating acute onset of chronic bronchitis.%目的:观察自拟银翘止嗽散治疗慢性支气管炎急性发作期的临床疗效.方法:80例确诊病例采用银翘止嗽散(方药组成:金银花30 g,连翘20 g,紫菀15 g,百部15 g,白前10 g,款冬花10 g,黄芩10 g,炙麻黄10 g,桔梗15 g,甘草5 g)治疗,水煎服,日1剂,10 d为1个疗程,全部病例治疗1~2个疗程.结果:治愈37例,显效28例,有效13例,无效2例,有效率为97.5%.结论:银翘止嗽散治疗慢性支气管炎急性发作疗效显著.

  7. 多索茶碱联合氨溴索治疗慢支急性发作的疗效观察%To Observe the Curative Effect of Doxofylline Combined With Ambroxol on Acute Attack of Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    矫维荣

    2015-01-01

    目的:探讨多索茶碱联合氨溴索治疗慢性支气管炎急性发作的临床疗效。方法入选我院2013年1月~2014年1月慢性支气管炎急性发作的患者80例,随机分为两组,观察组和对照组各40例,观察组给予多索茶碱联合氨溴索治疗,对照组单纯给予氨溴索治疗,观察两组的临床效果。结果治疗后,观察组与对照组相比,咳嗽、痰液消失的时间、干湿性啰音消失的时间,P<0.05,差异具有统计学意义。两组患者治疗的总有效率比较,观察组高于对照组,P<0.05,差异具有统计学意义。结论多索茶碱与氨溴索联合治疗慢性支气管炎急性发作效果显著,安全性高,不良反应少。%Objective To investigate the clinical effect of doxofylline combined with ambroxol treatment of acute attack of chronic bronchitis. Methods Selected 80 patients with acute attack of chronic bronchitis patients in our hospital, the observation group was given doxofylline combined with ambroxol treatment, the control group only received ambroxol treatment, to observe the clinical effects of two groups.Results Cough, sputum, dry time of the disappearance of rales disappear time signiifcantly statistical difference, total effective rate of observation group is obviously higher than that in control group. Conclusion Doxofylline combined with ambroxol treatment of acute exacerbation of chronic bronchitis the effect signiifcantly.

  8. 中西医结合治疗慢性支气管炎急性发作的临床分析%Clinical Analysis of Integrated Medicine in the Treatment of Acute Exacerbation of Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    王守振

    2015-01-01

    Objective Discussing method and clinical effect of integrated medicine in the treatment of acute exacerbation of chronic bronchitis, and summarizing experience to improve treatment level of oneself .Method 140 case of patients with acute exacerbation of chronic bronchitis in our department from May 2012 to May 2014 were randomly divided into control group and observation group .The control group was given Weston medicine .On the basis of the control group , the observation received Xiaoqinglong decoction additionally .The treatment result was recorded and statistically analyzed .Result The total effective rate of the observation group and the control group was 85.71%and 98.57%, respectively , and the difference was statistically significant ( P <0.05 ) .Conclusion The clinical effect of integrated medicine in the treatment of acute exacerbation of chronic bronchitis was superior to the individual effect of the Weston medicine , and was worthy of clinical further research and promotion .%目的:探讨中西医结合治疗慢性支气管炎急性发作的方法及其临床疗效,总结经验以提高自身治疗水平。方法将2012年5月—2014年5月我科收治的140例慢性支气管炎急性发作患者随机分成对照组和观察组,对照组给予单纯西医治疗,观察组在对照组基础上加用小青龙汤加减治疗,记录两组患者治疗结果并进行统计学分析。结果对照组、观察组的总有效率分别是85.71%、98.57%,二者差异具有统计学意义(P<0.05)。结论中西医结合治疗慢性支气管炎急性发作的临床疗效明显优于单纯西医治疗,值得在临床上进一步研究,加强推广。

  9. 对小儿急慢性支气管炎患儿进行特殊护理的临床研究%Clinical study of special nursing for children with acute and chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    齐金华

    2015-01-01

    AIM: To investigate the clinical effect of special nursing for children with acute or chronic bronchitis. METH⁃ODS: A total of 78 children with acute or chronic bronchitis admitted to our hospital from April 2014 to March 2015 were selected and divided into two groups based on the nursing method, with 39 cases in each group. RESULTS: The cure rate of the observation group was significantly higher than that of the control group (P<0.05), and the nursing satisfaction was significantly higher than that of the control group ( P<0. 05 ) . CONCLU⁃SION:To imply special nursing for children with acute or chronic bronchitis can increase the cure rate, improve the nursing satisfaction, and reduce the incidence of complications.%目的:探讨对小儿急慢性支气管炎患儿进行特殊护理的临床效果.方法:选取2014-04/2015-03我院收治的小儿急慢性支气管炎患儿78例,按照护理方法分成观察组( n=39)和对照组( n=39).观察组采用特殊护理,对照组采用常规护理,观察比较两组治愈率、护理满意度和并发症发生率.结果:观察组患儿治愈率明显高于对照组(P<0.05),护理满意度明显高于对照组(P<0.05),并发症发生率明显低于对照组( P<0.05).结论:对小儿急慢性支气管炎患儿进行特殊护理,能够提高患儿治愈率,提高护理满意度,降低并发症发生率.

  10. Analysis of the effect of ambroxol hydrochloride in the treatment of acute exacerbation of chronic bronchitis%盐酸氨溴索治疗慢性支气管炎急性发作的疗效分析

    Institute of Scientific and Technical Information of China (English)

    丁宁

    2014-01-01

    目的:观察盐酸氨溴索对慢性支气管炎急性发作的临床疗效。方法:选取2012年11月-2014年3月慢性支气管炎急性发作患者60例,随机分为对照组30例和试验组30例。对照组给予吸氧、抗感染、解痉平喘等常规治疗;试验组在常规治疗基础上加用盐酸氨溴索静脉滴注,每次30 mg,每日2次,5 d为1个疗程,共2个疗程,治疗结束后比较两组疗效。结果:试验组的总有效率为96.75%,对照组为76.7%,组间差异有统计学意义(P<0.05)。结论:盐酸氨溴索治疗慢性支气管炎急性发作有较好的临床疗效。%Objective:To observe the clinical effect of ambroxol hydrochloride in the treatment of acute exacerbation of chronic bronchitis. Methods: Sixty cases with acute exacerbation of chronic bronchitis were selected from Nov. 2012 to March 2014 and divided into a control group with 30 patients and an experiment group with 30 patients at the random. The control group was treated with oxygen inhalation, anti-infection, antispasmodic and the conventional therapy. The experiment group was added with ambroxol hydrochloride injection of 30 mg every time, twice a day, 5 days a course for 2 courses based on the conventional therapy. The treatment effects of two groups were compared after the treatment. Results:The total efifcacy was 96.7% in the experiment group, and 76.7% in the control group. The difference of the two groups had the statistical signiifcance (P<0.05). Conclusion:Ambroxol hydrochloride has a good clinical effect in the treatment of acute exacerbation of chronic bronchitis.

  11. 盐酸氨溴索用于慢性支气管炎急性加重期的疗效%Efficacy of ambroxol hydrochloride on acute anabasis of chronic bronchitis patients

    Institute of Scientific and Technical Information of China (English)

    张鑫

    2012-01-01

    目的 观察盐酸氨溴索辅助治疗慢性支气管炎急性加重期患者的气道净化疗效.方法 选择2009年10月-2011年10月在我科治疗的慢支急性发作患者80例,随机分成治疗组和对照组,各40例,治疗组给予抗生素+盐酸氨溴索30 mg,2次/d静点,对照组单纯使用抗生素,两组基础治疗相同,比较两组治疗后临床症状、体征、实验室检查恢复情况.结果 治疗组总有效率为97.5%,对照组为85%,两组比较,差异有统计学意义(P<0.01).结论 盐酸氨溴索静脉用药辅助治疗慢支急性发作可明显化痰、祛痰,改善呼吸,缩短病程,且药物不良反应小.%Objective To observe the airway purification effect of ambroxol hydrochloride in acute anabasis of chronic bronchitis patients. Methods 80 patients with acute attack of chronic bronchitis who cured in our department from October 2009 to October 2011 were selected. The patients were randomly divided into treatment group and control group with 40 cases in each group. Treatment group was given antibiotics + hydrochloride ammonia bromide cable 30 mg ductus venosus twice a day; Control group was only given antibiotics. The basic treatment of the two groups was the same. The clinical symptoms, signs, and laboratory check recovery situation of the two groups after treatment were compared. Results The total effective rate of treatment group and control group were 97. 5% and 85% respectively (P < 0. 01). Conclusion Ambroxol hydrochloride has good effect on the patients with acute exacerbation of chronic bronchitis by clearing phlegm,expectorant,improving breathing,shortening the course with few side effect.

  12. The clinical analysis of 32 cases of chronic bronchitis acute attacking by MRSA infection%MRSA 感染致慢性支气管炎急性发作32例临床分析

    Institute of Scientific and Technical Information of China (English)

    高成兵

    2013-01-01

    Objective: To analyze the clinical effect of treating chronic bronchitis acute at acking by MRSA infection. Methods: Choosed 32 cases of chronic bronchitis acute at acking by MRSA infection from Dec. 2010 to Dec. 2012 to sputum culture experiment and drug sensitive test and treat with vancomycin. Results: The antibiotic susceptible rate of MRSA was 100.0%, the effective rate of study group was 93.8%, adverse rate was 6.2%. Conclusion: There is high rate in primary hospital of chronic bronchitis acute at acking by MRSA infection, but MRSA is sensitive to vancomycin.%目的:分析 MRSA(耐甲氧西林金黄色葡萄球菌)感染所致慢性支气管炎急性发作期相关情况。方法:回顾性分析2010年12月-2012年12月大邑县人民医院呼吸科住院的慢性支气管炎急性发作期的 MRSA 感染患者32例,均行痰培养实验和药敏试验,并均采用万古霉素治疗,统计药敏试验结果和临床治疗情况。结果:MRSA 对万古霉素的敏感率达100.0%;治疗总有效率93.8%,不良反应率为6.2%,临床效果比较显著。结论:基层医院中社区获得性感染致慢性支气管炎的急性发作患者中也存在较高比率的 MRSA 感染;MRSA 对万古霉素敏感,尚未发现有耐药株。

  13. PM2.5浓度对老年慢性支气管炎急性发作的影响%Research PM2.5 concentration on acute onset of chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    翟文慧; 李勇; 路晶凯; 王伟; 黄志刚

    2015-01-01

    Objective To investigate the effect of PM2.5 concentration on acute onset of chronic bronchitis. Method The clinical data of Beijing city center and other areas were selected to monitor and record daily fine particulate air pollution around the station PM2.5, PM10 concentrations, and the average temperature, maximum temperature, minimum temperature, wind speed, relative humidity, barometric pressure, visibility seven meteorological factors. The number of cases of chronic bronchitis in patients with acute exacerbation everyday was recorded. Result ①Daily hospital visits attack was positively correlated with the concentration of PM2.5, with the average, maximum and minimum temperatures were negatively correlated, and the minimum temperature associated with relatively greater;same barometric pressure, relative humidity, wind speed and visibility were negatively correlated.②The number of acute exacerbation of chronic bronchitis as PM2.5 level increased and growth. Conclusion Acute exacerbation of chronic bronchitis affected by the concentration of PM2.5, PM2.5 concentration monitoring can play a role in early warning of the onset of senile acute and chronic respiratory diseases.%目的:探讨PM2.5浓度对老年慢性支气管炎急性发作的影响。方法选择北京市城市中心区及其他地区的患者资料,监测并记录每日医院周围大气细颗粒污染物PM2.5和PM10的浓度以及平均气温、最高气温、最低气温、风速、相对湿度、气压、能见度等7项气象因子。记录两地区每日老年慢性支气管炎急性发作患者例数。结果①每日住院的老年慢性支气管炎急性发作患者例数同PM2.5浓度呈正相关,同平均气温、最高气温、最低气温均呈负相关,且与最低气温相关度更大;同气压、相对湿度、风速及能见度均呈负相关。②老年慢性支气管炎急性发作患者例数随PM2.5等级升高而增多。结论老年慢性

  14. The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma

    OpenAIRE

    Nair Parameswaran; Ochkur Sergei I; Protheroe Cheryl; Simms Elizabeth; Lee Nancy A; Lee James J

    2011-01-01

    Abstract This case reports the unique association of eosinophilic gastrointestinal disease with eosinophilic bronchitis, asthma and chronic rhinosinusitis and some features of lymphocytic hypereosinophilic syndrome, describes a diagnostic protocol for patients with asthma and persistent eosinophilic bronchitis, and suggests that the use of a novel EPX-mAb provides a reliable method to identify eosinophilic inflammation.

  15. Clinical observation of acute exacerbation of chronic bronchitis treated by Shenbai Zhike mixture%参百止咳合剂治疗慢性支气管炎急性发作30例临床观察

    Institute of Scientific and Technical Information of China (English)

    闫国友; 张立民; 王兴

    2011-01-01

    目的 观察在西医常规治疗基础上应用参百止咳合剂治疗慢性支气管炎急性发作的临床疗效.方法 将60例慢性支气管炎急性发作患者随机分为2组,对照组30例予西医常规治疗,治疗组30例在对照组治疗基础上予参百止咳合剂治疗,2组均7d为1个疗程,治疗2个疗程后观察疗效,进行症状积分及实验室指标血清白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)比较.结果 治疗组总有效率90.0%,对照组总有效率80.0%,2组总有效率比较差异有统计学意义(P<0.05),治疗组疗效优于对照组.2组治疗后症状积分均较本组治疗前降低(P<0.05),且治疗组治疗后症状积分低于对照组(P<0.05).2组治疗后血清IL-8、TNF-α水平均较本组治疗前降低(P<0.05),且治疗组治疗后血清IL-8、TNF-α水平低于对照组(P<0.05).结论 参百止咳合剂治疗慢性支气管炎急性发作疗效确切,值得临床推广.%Objective To investigate the clinical effect of acute exacerbation of chronic bronchitis treated by Shenbai Zhike mixture. Methods 60 patients with acute exacerbation of chronic bronchitis were randomly divided into two groups. Patients in control group received routine western medicine. Patients in treatment group were treated by Shenbai Zhike mixture combined with routine western medicine. The course was seven days in two groups. After two courses the curative effect was observed. Symptoms score, IL - 8 and TNF -α were compared for evaluation of clinical effect. Results The total effective rate in treatment group (90.0% ) was higher than that in control group (80.0% , P <0.05). The symptoms score after treatment was decreased in compared with that before treatment in two groups ( P <0.05). And the symptoms score in treatment group was lower than that in control group after treatment ( P < 0.05 ). The levels of IL - 8 and TNF - α in treatment group were lower than those in control group after treatment ( P <0

  16. Observation of acute attack stage of chronic bronchitis treated by Zhikepingchuan prescription%止咳平喘方治疗慢性支气管炎急性发作期120例疗效观察

    Institute of Scientific and Technical Information of China (English)

    刘秀艳; 刘俊敏; 程国静; 刘宏

    2014-01-01

    目的:观察止咳平喘方治疗慢性支气管炎急性发作期的临床疗效。方法将240例慢性支气管炎急性发作期患者随机分为2组,对照组120例予西医常规治疗,治疗组120例在对照组治疗基础上加止咳平喘方治疗。治疗10 d后观察2组治疗前后肺功能指标第1 s用力呼气容积占预计值百分比( FEV1%)和FEV1/用力肺活量( FVC),并观察治疗前后咳嗽、咯痰、喘息等临床症状变化以评价临床疗效。结果治疗组总有效率93.33%,对照组总有效率82.50%,2组总有效率比较差异有统计学意义(P<0.05),治疗组临床疗效优于对照组。治疗组治疗后肺功能指标FEV1%及FEV1/FVC与本组治疗前及对照组治疗后比较均明显提高(P<0.05)。结论止咳平喘方治疗慢性支气管炎急性发作期,肺功能改善明显,疗效确切,患者耐受良好,安全性高。%Objective To observe the clinical effect of acute attack stage of chronic bronchitis treated by Zhikepingchuan prescription .Methods 240 patients with acute attack stage of chronic bronchitis were randomly di-vided into control group ,which was treated by routine therapy and treatment group ,which was treated by Zhikeping-chuan prescription on the basis of control group treatment .Pulmonary function indicatrix ( FEV1% and FEV1/FVC) were observed after 10 days of treatment.The changes of clinical symptoms such as cough ,sputum,breathing before and after treatment were observed and clinical effect was evaluated .Results The total effective rate in treatment group (93.33%)was higher than that in control group (82.50%,P<0.05).FEV1% and FEV1/FVC in treatment group were increased as compared with those in control group after treatment ( P<0 .05 ) .Conclusion Zhikeping-chuan prescription on the treatment of acute attack stage of chronic bronchitis can significantly improve patients with lung function,definite curative effect,well tolerated

  17. 慢性支气管炎合并肺炎患者血浆中D-二聚体检测的临床意义%Clinical significance of plasma D-dimer detection in chronic bronchitis complicated with pneumonia patients

    Institute of Scientific and Technical Information of China (English)

    刘海波

    2015-01-01

    目的:探讨慢性支气管炎合并肺炎患者血浆中D-二聚体检测的临床意义。方法慢性支气管炎急性发作合并肺炎患者64例和肺栓塞患者30例,对其D-二聚体进行快速定量测定。结果慢性支气管炎急性发作合并肺炎患者和肺栓塞患者D-二聚体差异无统计学意义(P>0.05)。结论检测D-二聚体为判断慢性支气管炎是否合并肺部感染有一定的意义,且有助于判断炎症的轻重及病情变化。%Objective To investigate clinical significance of plasma D-dimer detection in chronic bronchitis complicated with pneumonia patients.Methods There were 64 cases of chronic bronchitis acute attack complicated with pneumonia and 30 cases of pulmonary embolism. Rapid quantitative determination was made for D-dimer in all patients.Results The difference of D-dimer had no statistical significance between chronic bronchitis acute attack complicated with pneumonia patients and pulmonary embolism patients (P>0.05). Conclusion Detection of D-dimer provides certain value for judging whether chronic bronchitis is complicated with pulmonary infection. This method is also helpful to judging status of inflammation and disease.

  18. Bedeutung von Mykoplasmenspezies bei Katzen mit chronischer Bronchitis/felinem Asthma

    OpenAIRE

    Richter, Petra

    2012-01-01

    Etiology of feline bronchial disease remains unknown so far. However, in human medicine, Mycoplasma spp. infections have been made responsible for the exacerbation of asthmatic lung disease for a long time. Aim of this study was to investigate the relevance of Mycoplasma spp. infections for the development of chronic bronchitis/feline asthma. For this purpose, lavage samples of lungs and nose and nasal swabs where taken from cats with chronic bronchitis/feline asthma and from cats without ...

  19. 老年慢性支气管炎患者负性情绪及自尊感临床现状分析%Clinical analysis of negative emotions and self-esteem of elderly patients with chronic bronchitis

    Institute of Scientific and Technical Information of China (English)

    侯莉; 李家容; 王颖琦; 王玉兰

    2011-01-01

    目的:探讨老年慢性支气管炎患者负性情绪及自尊感的临床现状.方法:分别选取110例老年慢性支气管炎、110例慢性支气管炎非老年成人患者、110例正常体检健康成人依次设为观察组、对照组、正常对照组,均应用焦虑自评量表、Avillo的情绪情感形容词量表及Rosenberg自尊量表调查、比较其相关评分,比较不同临床特征观察组患者评分的差别.结果:观察组患者焦虑评分高于对照组、正常对照组(P<0.01),而情绪情感及自尊评分低于对照组、正常对照组(P<0.05,P<0.01);观察组患者焦虑、情绪情感及自尊评分与性别、婚姻状况、子女状况、经济收入密切相关(P<0.05);观察组患者焦虑与情绪情感评分具有负相关性(P<0.05),焦虑与自尊评分具有负相关性(P<0.01),情绪情感评分与自尊评分具有正相关性(P<0.05).结论:老年慢性支气管炎患者表现为明显的焦虑情绪、情绪情感水平下降、自尊感下降,尤其是女性、无配偶、子女不在身边及经济收入低的患者表现更明显,在临床中可针对此特点进行相关护理,从根源上提高其心理水平.%Objective: To analyze the clinical situation of negative emotions and self - esteem of elderly patients with chronic bronchitis. Methods: 110 elderly patients with chronic bronchitis, 110 non - elderly adult patients with chronic bronchitis and 110 healthy adults with routine physical examination were respectively selected and taken as the observation group, control group and normal control group. The anxiety self - rating scale, Avillo emotional adjective scale and Rosenberg self - esteem scale were used to conduct a survey and compare the scores and the different clinical features among the patients. Results: The anxiety scores were higher in the observation group than the control and normal control groups ( P <0. 01 ); emotion and self - esteem scores were lower in the observation

  20. An intervention with access to C-reactive protein rapid test reduces antibiotic overprescribing in acute exacerbations of chronic bronchitis and COPD

    DEFF Research Database (Denmark)

    F. Strykowski, David; Nielsen, Anni Brit Sternhagen; Llor, Carles;

    2015-01-01

    Background. In acute exacerbation of chronic obstructive pulmonary disease (AECOPD) antibiotic overprescribing leads to antimicrobial resistance and underprescribing may cause poor patient outcomes. Objective. This study aimed to evaluate changes in over- and underprescribing of antibiotics after...

  1. What Are the Signs and Symptoms of Bronchitis?

    Science.gov (United States)

    ... What Are the Signs and Symptoms of Bronchitis? Acute Bronchitis Acute bronchitis caused by an infection usually develops after you ... nose, vomiting, and diarrhea. The main symptom of acute bronchitis is a persistent cough , which may last 10 ...

  2. Clinical Practice Guidelines for Severe Chronic Obstructive Pulmonary Disease.

    OpenAIRE

    Niurka Mercedes Galende Hernández; Diosdania Alfonso Falcón; Carlos Alberto Martell Alonso; Alexis Díaz Mesa; Inti Santana Carballosa

    2009-01-01

    Clinical Practice Guidelines for Severe Chronic Obstructive Pulmonary Disease. This concept includes simple chronic bronchitis, asthmatic bronchitis, chronic obstructive bronchitis, and pulmonary emphysema; although this two last are the most commonly included. Risk factors, classification and treatment are commented, stressing the strategy of mechanical ventilation and the indications for mechanical invasive and no invasive ventilation. It includes assessment guidelines focused on the most i...

  3. Does a 10-valent pneumococcal-Haemophilus influenzae protein D conjugate vaccine prevent respiratory exacerbations in children with recurrent protracted bacterial bronchitis, chronic suppurative lung disease and bronchiectasis: protocol for a randomised controlled trial

    Science.gov (United States)

    2013-01-01

    Background Recurrent protracted bacterial bronchitis (PBB), chronic suppurative lung disease (CSLD) and bronchiectasis are characterised by a chronic wet cough and are important causes of childhood respiratory morbidity globally. Haemophilus influenzae and Streptococcus pneumoniae are the most commonly associated pathogens. As respiratory exacerbations impair quality of life and may be associated with disease progression, we will determine if the novel 10-valent pneumococcal-Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) reduces exacerbations in these children. Methods A multi-centre, parallel group, double-blind, randomised controlled trial in tertiary paediatric centres from three Australian cities is planned. Two hundred six children aged 18 months to 14 years with recurrent PBB, CSLD or bronchiectasis will be randomised to receive either two doses of PHiD-CV or control meningococcal (ACYW135) conjugate vaccine 2 months apart and followed for 12 months after the second vaccine dose. Randomisation will be stratified by site, age (, nasopharyngeal and saliva swabs, and serum will be collected at baseline and at 2, 3, 8 and 14 months post-enrolment. Local and systemic reactions will be recorded on daily diaries for 7 and 30 days, respectively, following each vaccine dose and serious adverse events monitored throughout the trial. Fortnightly, parental contact will help record respiratory exacerbations. The primary outcome is the incidence of respiratory exacerbations in the 12 months following the second vaccine dose. Secondary outcomes include: nasopharyngeal carriage of H. influenzae and S. pneumoniae vaccine and vaccine- related serotypes; systemic and mucosal immune responses to H. influenzae proteins and S. pneumoniae vaccine and vaccine-related serotypes; impact upon lung function in children aged ≥6 years; and vaccine safety. Discussion As H. influenzae is the most common bacterial pathogen associated with these chronic respiratory diseases in

  4. Plastic Bronchitis in an Adult with Asthma

    OpenAIRE

    Kim, Eun Jin; Park, Jung Eun; Kim, Dong Hoon; Lee, Jaehee

    2012-01-01

    Plastic bronchitis is a rare disease characterized by marked airway obstruction, via the formation of large gelatinous or rigid airway cast. In Korea, there were a few case reports with plastic bronchitis not in adults, but in children. So we report a case of an adult who was diagnosed as plastic bronchitis with eosinophilic casts, with no history of atopic and cardiac disease.

  5. 112例误诊为支气管炎的老年慢性咳嗽病因分析%Etiological investigation of the 112 elderly patients with chronic cough misdiagnosed as bronchitis

    Institute of Scientific and Technical Information of China (English)

    林芳; 王浩彦

    2012-01-01

    目的 探讨老年患者慢性咳嗽的误诊及病因分布.方法 基层医院误诊为支气管炎的112例老年慢性咳嗽患者,采用咳嗽诊治指南制定的诊断程序,判断病因并予针对性治疗.结果 最终病因明确107例(95.54%),其中单一病因为89例(79.46%),复合病因为18例(16.07%).老年患者病因诊断前三位为胃食管返流性咳嗽、咳嗽变异型哮喘 、上气道咳嗽综合征,在女性患者和男性患者中分别占26.39%,20.83%,18.06%和29.31%,22.41%,18.97%.三者占慢性咳嗽病因的67.69%,其次是ACEI诱发的咳嗽.经特异性治疗后咳嗽明显减轻或消失为103例,有效率为91.96%,其余均为部分缓解.结论 老年慢性咳嗽病因复杂常被误诊,规范慢性咳嗽病因诊断程序对提高老年慢性咳嗽诊治水平有重要意义.%Objective The purpose of this study is to explore the etiology and misdiagnosis of the elderly patients with chronic cough. Methods A total of 112 the elderly patients ( 62 females, 50 males ) with chronic cough misdiagnosed as bronchitis by primary hospital were studied. Based on " Guideline on Diagnosis and Treatment of Chronic Cough" established by China Medical, the causes of chronic cough would be confirmed and given specific therapy. Results 107 of 112 patients( 95. 54% )were finally confirmed. Chronic cough due to a single cause was found in 89 patients ( 79. 46% ), and due to two causes in 18 patients ( 16. 07% ). The top three causes were gastroesophageal reflux cough ( GERC ), cough variant asthma ( CVA ), upper airway cough syndrome ( UACS ) and accounted for 67. 69% , followed by the ACEI-induced cough. The three causes accounted for 26. 39% , 20. 83% , 18. 06% in females and 29. 31% , 22. 41% , 18. 97% in male patients, respectively. After specific therapy based on diagnosis, cough cured and alleviated in 103 patients (91. 96% ); the rest are partially alleviated. Conclusions The cause of chronic cough in the elderly is complex and often

  6. A clinical study on treatment of acute exacerbations of chronic bronchitis with Sangpa Zhike decoction%桑杷止咳汤治疗慢性支气管炎急性发作的临床研究

    Institute of Scientific and Technical Information of China (English)

    严兴海; 蔡基鸿; 游方; 张蕾; 吕翠芬; 徐姗姗; 潘慧娟

    2014-01-01

    目的:观察桑杷止咳汤治疗慢性支气管炎急性发作的临床效果。方法选择2012年8月至2013年8月在新疆昌吉回族自治州中医医院门诊就诊的慢性支气管炎急性发作患者180例,按随机数字表法将患者分为桑杷止咳汤治疗组和西医治疗对照组,每组90例。两组均给予一般治疗,桑杷止咳汤治疗组在一般治疗的基础上加服桑杷止咳汤(组成:桑白皮10 g,枇杷叶10 g,鱼腥草10 g,蜜紫菀15 g,蜜款冬花6 g,浙贝母12 g,苏子10 g,白芥子6 g,桔梗10 g,白前12 g,陈皮6 g,百部6 g)每日1剂,水煎分2次服用;西医治疗对照组给予控制感染、止咳化痰等治疗方法,疗程均为7d。观察两组治疗前后中医证候疗效和咳嗽症状量化评分的变化。结果桑杷止咳汤治疗组治愈率明显高于西医治疗对照组〔70.00%(63/90)比33.33%(30/90),P<0.01〕。两组治疗前咳嗽症状量化评分比较差异无统计学意义,治疗后咳嗽症状量化积分均较治疗前明显降低,且以桑杷止咳汤治疗组降低更显著(分:1.66±1.12比4.36±2.32,P<0.01)。结论桑杷止咳汤治疗慢性支气管炎急性发作疗效显著。%Objective To observe the clinical effect of Sangpa Zhike decoction in the treatment of acute exacerbations of chronic bronchitis. Methods 180 patients with acute exacerbation of chronic bronchitis admitted to Autonomous Prefecture Hospital of traditional Chinese medicine(TCM)in Changji,Xinjiang,from August 2012 to August 2013 were enrolled. They were divided into Sangpa Zhike decoction treatment group and western medicine treatment control group by random number table,90 cases in each group. General treatments were given to the two groups. In the Sangpa Zhike decoction treatment group,additionally only oral Sangpa Zhike decoction was given(composition:Morus alba 10 g,loquat leaf 10 g,Houttuynia 10 g,honey aster 15 g,honey coltsfoot flower

  7. Role of PGE2 in Asthma and Nonasthmatic Eosinophilic Bronchitis

    OpenAIRE

    Beatriz Sastre; Victoria del Pozo

    2012-01-01

    Eosinophilic bronchitis is a common cause of chronic cough, which like asthma is characterized by sputum eosinophilia, but unlike asthma there is no variable airflow obstruction or airway hyperresponsiveness. Several studies suggest that prostaglandins may play an important role in orchestrating interactions between different cells in several inflammatory diseases such as asthma. PGE2 is important because of the multiplicity of its effects on immune response in respiratory diseases; however, ...

  8. Oral Fluoroquinolones in the Treatment of Pneumonia, Bronchitis and Sinusitis

    OpenAIRE

    Mittmann, Nicole; Jivraj, Farah; Wong, Angelina; Yoon, Alice

    2002-01-01

    BACKGROUND: Despite a relatively large number of clinical studies comparing oral fluoroquinolones to one antibiotic class comparator, there is limited information on the relative efficacy of different fluoroquinolones.OBJECTIVE: To examine the efficacy and tolerability of oral fluoroquinolones in the treatment of mild to moderate community-acquired pneumonia, acute exacerbations of chronic bronchitis and sinusitis.METHODS: A systematic review was undertaken with a MEDLINE search for antibioti...

  9. Efficacy and Safety of Pharmacokinetically Enhanced Amoxicillin-Clavulanate at 2,000/125 Milligrams Twice Daily for 5 Days versus Amoxicillin-Clavulanate at 875/125 Milligrams Twice Daily for 7 Days in the Treatment of Acute Exacerbations of Chronic Bronchitis

    OpenAIRE

    Sethi, Sanjay; Breton, John; Wynne, Brian

    2005-01-01

    This randomized, controlled trial was designed to show that a short, 5-day course of pharmacokinetically enhanced amoxicillin-clavulanate at 2,000/125 mg (Augmentin XR) is as effective clinically as a longer, 7-day course of conventional amoxicillin-clavulanate at 875/125 mg (both given twice daily) in the treatment of acute exacerbations of chronic bronchitis (AECB). Amoxicillin-clavulanate at 2,000/125 mg was designed to extend the therapeutic levels of amoxicillin in serum over the 12-h do...

  10. 三拗片治疗急、慢性支气管炎风寒袭肺证80例分析%Treatment of acute and chronic bronchitis with syndrome of wind- cold attacking lung with San'ao tablets: An analysis of 80 cases

    Institute of Scientific and Technical Information of China (English)

    陈麒; 张炜; 张学超

    2012-01-01

    Objective To observe the clinical effect of treatment of acute and chronic bronchitis in acute stage with syndrome of wind - cold attacking lung with San'ao tablets. Methods Eighty cases of acute and chronic bronchitis in acute stage with syndrome of wind - cold attacking lung were treated with San'ao tablets for 7 days. The changes of clinical symptoms such as cough, sputum, wheeze were observed on the first day, the fifth and the seventh day. Results The total efficacy rate of San'ao tablets for treating acute and chronic bronchitis in acute stage with syndrome of wind-cold attacking lung was 93.75% . The main symptoms such as cough, expectoration and wheeze were significantly relieved. Conclusion San'ao tablets have an obvious clinical effect on a-cute and chronic bronchitis in acute stage with syndrome of wind- cold attacking King.%目的 观察三拗片治疗急性支气管炎和慢性支气管炎急性发作期风寒袭肺证的临床疗效.方法 将80例急性支气管炎和慢性支气管炎急性发作期风寒袭肺证患者给予三拗片治疗7d,观察患者治疗当日、第5天与第7天临床症状咳、痰、喘的变化.结果 三拗片对急、慢性支气管炎急性发作期风寒袭肺证患者的总有效率为93.75%,对主症咳嗽、咳痰和喘息具有明显改善作用.结论 三拗片可改善急性支气管炎和慢性支气管炎急性发作期风寒袭肺证患者的临床症.

  11. β-carotene protects rats against bronchitis induced by cigarette smoking

    Institute of Scientific and Technical Information of China (English)

    庞宝森; 王辰; 翁心植; 唐小奈; 张红玉; 牛淑洁; 毛燕玲; 辛平; 黄秀霞; 张海燕; 祝锦

    2003-01-01

    Objective To investigate the protective effects of β-carotene in rats against the development of chronic bronchitis induced by cigarette smoking. Results Long-term cigarette smoking caused an obvious increase in the amount of IL-6, IL-8 and LPO and a sharp decrease in the levels of NO and SOD in smoking animals compared to controls. β-carotene intake reversed all the changes induced by smoking and alleviated the pathological changes caused by chronic bronchitis. Conclusions Quantitative oral intake of β-carotene had protective effects against chronic bronchitis induced by long-term cigarette smoking, which was associated with the increased production of NO, the clearance of some oxidative free radicals (OFR) and the alleviation of chronic inflammation.

  12. 慢性支气管炎急性发作采用阿奇霉素与左氧氟沙星门诊治疗的临床体会%Clinical Experience of Azithromycin and Levofloxacin in the Treatment of Acute Exacerbation of Chronic Bronchitis in Outpatient

    Institute of Scientific and Technical Information of China (English)

    杨鸿雁

    2014-01-01

    目的:研究慢性支气管炎急性发作采用阿奇霉素与左氧氟沙星门诊治疗的临床效果。方法选取68例患者将其分为治疗组和对照组,均34例,对比治疗效果。结果对比两组患者临床治疗总有效率和症状缓解时间,治疗组患者同对照组患者间具有明显差异性,P<0.05。结论阿奇霉素与左氧氟沙星对慢性支气管炎急性发作效果显著。%Objective The clinical effect of azithromycin and levofloxacin in the treatment of outpatients of acute exacerbations of chronic bronchitis. Methods 68 patients were divided into treatment group and control group were 34 cases, treatment effect, comparison. Results The clinical treatment of the two groups were compared and the total effective rate and the duration of remission, patients in the treatment group with the control has obvious differences between the groups with P<0.05. Conclusion Azithromycin and levofloxacin on acute attack of chronic bronchitis effect.

  13. Get Smart: Know When Antibiotics Work - Bronchitis (Chest Cold)

    Science.gov (United States)

    ... Farm Get Smart About Antibiotics Week Bronchitis (Chest Cold) Language: English Español (Spanish) Recommend on Facebook Tweet ... types—acute bronchitis. Causes Acute bronchitis, or chest cold, often occurs after an upper respiratory infection like ...

  14. Preventive and Curative Effects of Card Shu Ning Combined with Influenza Vaccine on Senile Chronic Bronchitis Complicated with Acute Infection%卡舒宁联合流感疫苗对老年性慢性支气管炎合并急性感染的防治效果

    Institute of Scientific and Technical Information of China (English)

    高忠翠; 李江涛; 展胜

    2011-01-01

    目的 观察卡舒宁联合流感疫苗对老年性慢性支气管炎合并急性感染的防治效果.方法 选择多年反复感染、咳嗽、咳痰、不同程度哮喘的老年慢性支气管炎患者138人,随机分为观察组73人,对照组65人.观察组接种流感疫苗后2周注射卡舒宁,每周2次,疗程3个月;对照组仅注射卡舒宁,方法 同观察组.1年后,对两组病例统一进行电话或人户随访,内容包括慢性支气管炎急性感染次数、急性感染时住院次数及急性感染时抗生素治疗疗程.结果 观察组患者慢性支气管炎急性感染次数和住院总次数明显减少,抗生素治疗疗程明显缩短,与对照组相比,差异均有统计学意义(P<0.01).结论 卡舒宁联合流感疫苗可明显提高老年性慢性支气管炎合并急性感染的防治效果.%Objective To observe the preventive and curative effects of Card Shu Ning combined with influenza vaccine on senile chronic bronchitis complicated with acute infection. Methods A total of 138 patients with senile chronic bronchitis complicated with cough, expectoration and asthma at various degrees, who were infected repeatedly during the past years, were divided into trial (73 cases) and control (65 cases) groups randomly. The patients in trial group were inoculated with influenza vaccine and injected with Card Shu Ning 2 weeks later, while those in control group were injected with Card Shu Ning alone, twice a week for 3 months. Telephone or in-home follow-up was performed on the patients one year later, including the times of acute infpction with chronic bronchitis, times of hospitalization due to acute infection and the course of treatment of acute infection with antibiotics. Results Compared with those in control group, the times of acute infection with chronic bronchitis and the times of hospitalization due to acute infection of patients in trial group decreased significantly, while the course of treatment with antibiotics was

  15. Plastic bronchitis in beta thalassemia minor

    OpenAIRE

    Makaresh Yadav; Sneha Tirpude; Joshi, Jyotsna M.

    2013-01-01

    Plastic bronchitis is a rare pulmonary disorder associated with various conditions like cystic fibrosis, asthma, pulmonary infection and characterized by formation and expectoration of cast which assumes the shape of the bronchial tree. We report a case of a 33-year-old woman with beta thalassemia minor who developed plastic bronchitis.

  16. Chronic obstructive pulmonary disease

    OpenAIRE

    NR Anthonisen

    2007-01-01

    The global prevalence of physiologically defined chronic obstructive pulmonary disease (COPD) in adults aged >40 yr is approximately 9-10 per cent. Recently, the Indian Study on Epidemiology of Asthma, Respiratory Symptoms and Chronic Bronchitis in Adults had shown that the overall prevalence of chronic bronchitis in adults >35 yr is 3.49 per cent. The development of COPD is multifactorial and the risk factors of COPD include genetic and environmental factors. Pathological changes in COPD are...

  17. 慢性阻塞性肺疾病与急性支气管炎肺功能的对比研究%The comparable study of lung function between patients with chronic obstructive pulmonary disease and patients with acute bronchitis

    Institute of Scientific and Technical Information of China (English)

    叶江枫; 袁名辉; 蒙育林

    2014-01-01

    目的:探讨脉冲振荡法(IOS)在慢性阻塞性肺疾病(COPD)、急性支气管炎的检测意义。方法选择100例COPD患者、100例急性支气管炎患者与正常对照者100例行常规肺通气功能及IOS检测。观察VC、FVC、FEV1%、FEV1/FVC、MMEF、VMAX、MVV;Fres、Zrs、R5、R20、R35、X5、Rc、Rp。结果 COPD组与正常组比较,VC、FVC、FEV1%、FEV1/FVC、MMEF、VMAX、MVV明显降低,P<0.05;Zrs、Fres、R5、R35、X5、R20、Rp明显升高,P<0.05。急性支气管炎组与正常组比较,VC、FVC、FEV1%、MVV明显降低,P<0.05;Zrs、Fres、R5、R20、R35、X5、Rp明显升高,P<0.01。COPD组与急性支气管炎组比较,VC、FVC、FEV1%、FEV1/FVC、MMEF、VMAX明显降低,P<0.01;Zrs、Fres、R5、R20、R35、X5、Rp明显升高,P<0.01。结论 COPD存在阻塞性和限制性通气功能障碍,急性支气管炎存在限制性通气功能障碍;COPD、急性支气管炎均存在总气道阻力、周边气道阻力、周边弹性阻力异常升高。COPD气道阻力升高更明显。%Objective To explore the clinical application value of impulse oscillometry (IOS) in patients with chronic obstructive pulmonary disease (COPD) and acute bronchitis. Methods To compare the parameters of pulmonary ventilation function with the results of respiratory impedance measured by impulse oscillometry in 100 patients with COPD group, 100 patients with acute bronchitis and 100 healthy adults.To observe VC, FVC, FEV1%, FEV1/FVC, MMEF, VMAX, MVV, Fres, Zrs, R5, R20, R35, X5, Rc, Rp. Results There were significant decrease in VC, FVC, FEV1%, FEV1/FVC, VMAX, MVV, P<0.05. There were significant rise in Zrs, Fres, R5, R35、X5, R20, Rp, P<0.05 in COPD group compared with normal group. There were decrease in VC, FVC, FEV1%, MVV, P<0.05;there were significant rise in Zrs, Fres, R5, R20, R35, X5, Rp, P<0.01 in acute bronchitis group compared with normal group. There were significant decrease in VC, FVC

  18. 应用雾化吸入利多卡因治疗慢性喘息型支气管炎急性发作的临床效果探讨%Application Clinical Effect on Atomizing Inhalation of Lidocaine for the Treatment of Chronic Wheezing Bronchitis Acute Episodes

    Institute of Scientific and Technical Information of China (English)

    芦万杰

    2015-01-01

    Objective To explore the clinical effect on atomization inhalation of lidocaine for the treatment of chronic wheezing bronchitis acute. Methods Selected 56 cases of chronic wheezing bronchitis acute episodes in our hospital as the observation group, patients with retrospective analysis of early departments of the clinical data of 55 patients with conditions similar to the control group. Control group patients received routine western medicine treatment, give atomization inhalation of lidocaine treatment group patients. To investigate the clinical therapeutic effect in both groups and contrast. Results Atomization inhalation of lidocaine treatment in the observation group of patients clinical treatment the total effective rate was 91.07%, significantly higher than the 78.18% of the control group treated with conventional treatment, compare the differences between groups,χ2=7.775, P<0.05,had statistically signiifcance. Conclusion The type of chronic wheezing bronchitis acute clinical treatment process, atomization inhalation of lidocaine therapy has good clinical effect, the recurrence rate is low.%目的:探讨雾化吸入利多卡因治疗慢性喘息型支气管炎急性发作的临床效果。方法选取在我院接诊的56例慢性喘息型支气管炎急性发作患者为观察组,回顾性分析早期我院接诊的55例条件相似的患者的临床资料,设为对照组。对照组患者接受常规西医治疗,给予观察组患者雾化吸入利多卡因治疗。对两组患者临床治疗效果进行调查和对比。结果接受雾化吸入利多卡因治疗的观察组患者临床治疗总有效率为91.07%,高于接受常规治疗的对照组患者的78.18%,χ2=7.775,P<0.05,差异具有统计学意义。结论在慢性喘息型支气管炎急性发作的临床治疗过程中,雾化吸入利多卡因治疗具有较好的临床效果,复发率较低。

  19. 沐舒坦雾化吸入治疗老年慢性支气管炎急性发作临床观察%Clinical observation of mucosolvan atomizing inhalation in the treatment of acute exacerbations of chronic bronchitis in eldly patients

    Institute of Scientific and Technical Information of China (English)

    孟蕾; 朱剑

    2015-01-01

    目的:观察沐舒坦雾化吸入治疗老年慢性支气管炎急性发作患者的临床疗效。方法:收治老年慢性支气管炎急性发作患者106例,分为雾化吸入组和静脉滴注组,雾化吸入组给予沐舒坦雾化吸入治疗,静脉滴注组给予沐舒坦静脉滴注治疗,比较两组疗效。结果:雾化吸入组的临床治疗总有效率明显高于静脉滴注组,咳嗽缓解时间、喘息缓解时间明显早于静脉滴注组,住院时间明显短于静脉滴注组(P<0.05)。结论:沐舒坦雾化吸入治疗老年慢性支气管炎急性发作患者起效更快,临床治疗效果更确切。%Objective:To explore the clinical effect of mucosolvan aerosol inhalation in the treatment of acute exacerbations of chronic bronchitis in eldly patients.Methods:106 elderly patients with acute exacerbation of chronic bronchitis patients were selected.They were divided into the atomizing inhalation group and intravenous infusion group.The atomizing inhalation group was given mucosolvan aerosol inhalation.The intravenous infusion group was given ambroxol intravenous drip treatment.We compared the efficacy of two groups.Results:In the atomizing inhalation group,the total efficiency of clinical treatment was significantly higher than that of intravenous infusion group;the remission time of cough,the remission time of breathing were significantly earlier than the intravenous infusion group;the hospitalization time was significantly shorter than the intravenous infusion group(P<0.05).Conclusion:The onset of mucosolvan aerosol inhalation in the treatment of acute exacerbations of chronic bronchitis in eldly patients was faster.Clinical therapeutic effect was more precise.

  20. Clinical Observation on Effect of Etimicin Sulfate Plus Cefmetazole Sodium on Acute Attack of Chronic Bronchitis%硫酸依替米星联合头孢美唑钠治疗慢性支气管炎急性发作的临床观察

    Institute of Scientific and Technical Information of China (English)

    袁艺

    2015-01-01

    目的:观察硫酸依替米星联合头孢美唑钠治疗慢性支气管炎急性发作的疗效。方法:将100例慢性支气管炎急性发作的患者随机分成对照组和研究组,每组50例。对照组单纯给予头孢美唑钠治疗,研究组给予硫酸依替米星联合头孢美唑钠治疗,进行临床疗效观察。结果:研究组临床有效率为89.5%,而对照组临床有效率为50.5%,研究组有效率明显高于对照组,差异有统计学意义( P<0.05)。结论:硫酸依替米星联合头孢美唑钠可有效治疗慢性支气管炎急性发作。%Objective:To observation the effect of etimicin sulfate plus cefmetazole sodium on the onset of chronic bronchitis .Methods:Ramdomly divide 100 cases of patients who were attacked acutely by chronic bronchitis into control group and research group ,50 cases for each .Treat the control group with cefmetazole sodium while the research group were treated with etimicin sulfate plus cefmetazole sodium .Make observa‐tion on the clinical effect .Results:The clinical effective rate of the research group was 89 .5% while that of the control group was 50 .5% ,the effective rate of the research group was obviously higher than that of the control group ,the difference was statistically significant ( P < 0 .05 ) .Conclusion:Etimicin sulfate plus cefmetazole sodium can effectively treat the acute attack of chronic bronchitis .

  1. Suhuang Capsule on Acute Attack of Senile Chronic Bronchitis the Curative Effects of the Patients With Observation%苏黄止咳胶囊对老年慢性支气管炎急性发作期患者的疗效观察

    Institute of Scientific and Technical Information of China (English)

    胡秋月

    2015-01-01

    目的:探讨苏黄止咳胶囊治疗老年慢性支气管炎急性发作期的临床疗效。方法选取124例慢性支气管炎急性发作期老年患者为研究对象,将其随机分为对照组和治疗组各62例,对照组给予常规治疗,治疗组在常规治疗的基础上采用苏黄止咳胶囊治疗,对比分析两组的治疗效果。结果治疗组患者临床治疗效果显著高于对照组,差异具有统计学意义(χ2=6.317,P<0.05)。结论采用苏黄止咳胶囊治疗处于慢性支气管炎急性发作期的老年患者,安全性高,治疗效果好,值得临床推广使用。%ObjectiveTo investigate the clinical curative effect of Suhuangzhike capsule in the treatment of senile chronic bronchitis in acute attack period. MethodsSelected 124 cases of acute exacerbation of chronic bronchitis in senile patients as the research object, then they were randomly divided into control group and treatment group with 62 cases in each group, the control group was given conventional treatment, the treatment group used Suhuangzhike capsule treatment on the basis of conventional therapy, compared two groups of treatment effect.ResultsThe clinical effect of the treatment of the patients in the treatment group was significantly higher than the control group, with signiifcant difference (χ2=6.317,P<0.05).Conclusion The use of Suhuangzhike capsule in the treatment of elderly patients with chronic bronchitis in acute attack period, high security, good therapeutic effect, is worthy of clinical use.

  2. Anti-inflammatory drugs and experimental bronchitis.

    Science.gov (United States)

    Jeffery, P K

    1986-01-01

    Chronic bronchitis (chronic hypersecretion) and chronic bronchiolitis (small airways disease) are two conditions associated with cigarette smoking: both contribute to airflow obstruction in man, the latter associated with progressive deterioration in lung function. Mucous metaplasia and hyperplasia are characteristic histological changes. Experimentally, cigarette smoke given daily for two weeks, induces similar histological changes in the airways of specific pathogen-free rats, providing a suitable animal model for study: an early proliferation of basal cells, accompanied by mucous metaplasia of surface epithelial serous cells is followed by proliferation of newly formed mucous cells. There is also a significant increase in epithelial thickness due to cell hypertrophy without stratification or prior ulceration. Experimentally, secretory cell hyperplasia is inhibited completely or to varying degrees by prophylactic administration (intraperitoneal injection) of either indomethacin, flurbiprofen, dexamethasone, prednisolone, hydrocortisone (each at 2 or 4 mg/kg body weight) or a mucolytic drug, N-acetylcysteine(Nac), given orally as a 1% solution of the drinking water. Nac also inhibits the associated mucus-hypersecretion. It takes between 21 and 84 days, depending on airway level, for the increase in secretory cell number to return to control values (ie recover). Indomethacin and flurbiprofen (4 mg/kg, by ip injection) shorten recovery to between 4 and 9 days in intrapulmonary airways but have no effect on recovery time in the rat trachea. Nac is effective in 6 of 7 airway levels which showed cigarette smoke-induced mucous cell hyperplasia. In conclusion, in the rat, the response to cigarette smoke is one of mucous cell metaplasia and both basal and mucous cell proliferation. Cigarette smoke-induced mucous cell hyperplasia can be inhibited when selected drugs are given concurrently with the cigarette smoke: indomethacin, fluriprofen and Nac are also therapeutic

  3. High-dose oral N-acetylcysteine fails to improve respiratory health status in patients with chronic obstructive pulmonary disease and chronic bronchitis: a randomized, placebo-controlled trial

    OpenAIRE

    Johnson K; McEvoy CE; Naqvi S.; Wendt C; Reilkoff RA; Kunisaki KM; Wetherbee EE; Nelson D; Tirouvanziam R; Niewoehner DE

    2016-01-01

    Kara Johnson,1,2 Charlene E McEvoy,3 Sakina Naqvi,1,4 Chris Wendt,1 Ronald A Reilkoff,4,5 Ken M Kunisaki,1 Erin E Wetherbee,1 David Nelson,6 Rabindra Tirouvanziam,7 Dennis E Niewoehner1 1Pulmonary Section, Minneapolis VA Health Care System, Minneapolis, MN, 2Sanford Health, Fargo, ND, 3Pulmonary Section, HealthPartners Research Foundation, St Paul, 4HealthEast Maplewood Clinic, Maplewood, 5Pulmonary Section, University of Minnesota Medical Center, 6Center for Chronic Disease Outcomes Researc...

  4. 支气管哮喘和慢性喘息型支气管炎患者发作期呼吸音的分析研究%Spectral analysis of breath sounds in asthmatics and chronic asthmatic bronchitis during acute episode

    Institute of Scientific and Technical Information of China (English)

    辛晓峰; 殷凯生; 张希龙; 施毅; 黄小平

    2003-01-01

    Objectives:To evaluate and differentiate the spectral characteristics of the breath sounds in patients with asthmatics and chronic asthmatic bronchitis during episode. Methods:The breath sounds in 10 patients with asthmatics and 8 patients with chronic asthmatic bronchitis during episode were recorded by using microphone and computer and analyzed with FFT(fast-Fourier transform). Results: No difference of the expiratory frequency and intensity was found between the wheezes in patients with asthmatics[PF=(388.42±82.43)Hz, Q25%=(312.96±66.88)Hz,Q50%=(422.24±91.16)Hz,Q75%=(538.76±110.22)Hz, LSI=(23.21±0.82)dB,respectively],and chronic asthmatic bronchitis[PF=(359.43±45.46)Hz,Q25%=(296.98±67.84)Hz,Q50%=(421.43±91.82)Hz,Q75%=(523.287±60.16)Hz,LSI=(23.11±0.56)dB, respectively] during episode(P>0.05). However, during episode the inspiratory frequencies in patients with chronic asthmatic bronchitis[PF=(176.68 ±36.84)Hz,Q25%=(171.32±32.64)Hz,Q50%=(229.69±31.87)Hz,Q75%=(382.36±55.21)Hz, respectively] was significantly lower than that in asthmatics [PF=(354.21±67.58)Hz,Q25%=(286.42±53.68)Hz,Q50%=(386.77±74.18)Hz,Q75%=(554.68±84.72)Hz,respectively,P0.05);发作期慢喘支患者吸气时的频率比发作期哮喘患者低[两组的PF,Q25%,Q50%,Q75%分别为(176.68±36.84)Hz,(171.32±32.64)Hz,(229.69±31.87)Hz,(382.36±55.21)Hz和(354.21±67.58)Hz,(286.42±53.68)Hz,(386.77±74.18)Hz,(554.68±84.72)Hz,P<0.05或P<0.01]. 结论:哮喘和慢喘支患者发作期呼吸音的频谱分析,有助于发作期哮喘和发作期慢喘支的诊断和鉴别诊断.

  5. Acute Bronchitis - Multiple Languages: MedlinePlus

    Science.gov (United States)

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Acute Bronchitis URL of this page: https://medlineplus.gov/languages/acutebronchitis.html Other topics A-Z A B ...

  6. Clinical Effect of Atomization Inhalation of Lidocaine for Treatment of Acute Attack of Chronic Asthmatic Bronchitis%雾化吸入利多卡因治疗慢性喘息型支气管炎急性发作的临床疗效

    Institute of Scientific and Technical Information of China (English)

    张欢

    2015-01-01

    ObjectiveTo discuss and study the clinical effect and significance of atomization inhalation of lidocaine for treatment of acute attack of chronic asthmatic bronchitis.MethodRandomly selected patients in pediatric acute episode of chronic asthmatic bronchitis in 100 cases and divided into combination group and common group both with 50 cases. Common group was given routine treatment and combination group was given atomization inhalation of lidocaine on basis of routine treatment. After different treatments, total effective rate and blood gas analysis of the 2 groups were compared. ResultTotal effective rate of combination group was 100% obviously higher than common group 78%(P<0.05). Changes of blood gas analysis of combination group were obvious superior to common group (P<0.05).ConclusionAtomization inhalation of lidocaine for treatment of acute attack of chronic asthmatic bronchitis has signiifcant clinical effect. It can effectively restrain smooth muscle contraction, reduce bronchial hyperresponsiveness and obviously relieve breathing phenomenon of patients within a short time. Besides, it can also relieve edema and inlfammatory reaction, and effectively control acute attack of bronchitis.%目的:研究利多卡因雾化吸入用于治疗慢性喘息型支气管炎发作的临床疗效与意义。方法随机选取就诊于我院儿科慢性喘息型支气管炎急性发作患儿100例。分组为联合组、普通组,各50例。其中为普通组患者进行常规治疗;联合组给在常规治疗基础上联合雾化吸入利多卡因。比较两组患者经过不同治疗后总有效率、血气分析等指标。结果两组患者不同治疗后总有效率的比较,显示治疗后联合利多卡因雾化吸入患者总有效率为100%,显著优于常规治疗组78%(P<0.05),联合组治疗效果较好;治疗前后血气分析值比较显示联合组与普通组治疗前血气分析值无显著差异(P>0.05)。治疗后联合组血

  7. Clinical Practice Guidelines for Severe Chronic Obstructive Pulmonary Disease. Guía de práctica clínica para el tratamiento de la enfermedad pulmonar obstructiva crónica grave.

    OpenAIRE

    Inti Santana Carballosa; Alexis Díaz Mesa; Carlos Alberto Martell Alonso; Diosdania Alfonso Falcón; Niurka Mercedes Galende Hernández

    2009-01-01

    Clinical Practice Guidelines for Severe Chronic Obstructive Pulmonary Disease. This concept includes simple chronic bronchitis, asthmatic bronchitis, chronic obstructive bronchitis, and pulmonary emphysema; although this two last are the most commonly included. Risk factors, classification and treatment are commented, stressing the strategy of mechanical ventilation and the indications for mechanical invasive and no invasive ventilation. It includes assessment guidelines focused on the most i...

  8. The Efficacy of Tanreqing for Treating Acute Exacerbation of Chronic Bronchitis and Its Impact on Immunoglobulin Levels of IgA, IgG and IgM%痰热清治疗慢性支气管炎急性发作的疗效及对免疫球蛋白IgA、IgG和IgM的影响

    Institute of Scientific and Technical Information of China (English)

    王琼

    2013-01-01

      [目的]探讨痰热清治疗慢性支气管炎(chronic bronchitis,CB)急性发作的疗效及对免疫球蛋白IgA、IgG和IgM的影响。[方法]将自2011年2月至2012年2月我院收治的60例CB急性发作患者随机分为对照组和观察组,每组30例。所有患者均给予基础治疗,对照组在基础治疗上给予庆大霉素、地塞米松、α糜蛋白酶雾化吸入,观察组则在基础治疗上给予痰热清注射液静脉滴注,观察两组患者的疗效、临床症状改善情况及免疫球蛋白IgA、IgG和IgM水平变化情况。[结果]观察组患者的总有效率为96.67%显著高于对照组的80%(χ2=4.04,P<0.05);观察组各临床症状的改善时间均明显短于对照组(P<0.05);观察组治疗后免疫球蛋白IgA、IgG和IgM的水平显著低于对照组(P<0.05)。[结论]采用痰热清治疗CB急性发作疗效显著,能有效缩短临床症状的缓解时间,改善免疫球蛋白IgA、IgG和IgM的水平,增强机体免疫功能,促进患者尽快康复。%  [Objective]To explore the clinical efficacy of Tanreqing for treating acute exacerbation of chronic bronchitis and its impact on immunoglobulin levels of IgA, IgG and IgM. [Methods] 60 cases with acute exacerbation of chronic bronchitis admitted in our hospital from February 2010 to February 2012 were randomly divided into control group and observation group, and each group had 30 cases. Al of the patients were given basic treatment; the control group was given gentamicin, dexamethasone and alpha chymotrypsin aerosol inhalation on the basis of the basic treatment, while the observation group was given Tanreqing intravenous injection;the efficacy, clinical symptoms improving situation and the changes of immunoglobulin levels of IgG and IgM were compared between the two groups. [Results] The total effective rate of the observation group was 96.67% significantly higher than 80% of the control group(χ2=4.04); the

  9. Molecular mechanisms of recurrent acute obstructive bronchitis in infants

    OpenAIRE

    Abaturov A.E.; Rusakova E.A.

    2015-01-01

    The article discusses the clinical and immunological features and mechanisms of recurrent acute obstructive bronchitis in infants. We have examined 102 children aged from 6 months to 3 years with acute obstructive bronchitis and signs of respiratory insufficiency of the I-II degree. There were 28 children with recurrent acute obstructive bronchitis and 74 patients with acute obstructive bronchitis,developed for the first time. We determined the concentration of total IgE, content of IFN-і, IL...

  10. 氨溴索、布地奈德雾化吸入联合治疗慢支急性发作的临床疗效%Ambroxol and Budesonide Aerosol Inhalation in Treatment of Acute Exacerbation of Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    董凤霞

    2015-01-01

    目的:探讨氨溴索、布地奈德雾化吸入联合治疗慢支急性发作的临床疗效。方法选取2012年10月~2014年9月在我院接受治疗的慢支急性发作患者108例,并根据患者具体情况分为观察组和对照组各54例,对照组采用常规综合方法进行治疗,观察组在对照组基础上加用氨溴索、布地奈德雾化吸入联合治疗,观察并比较两组的治疗效果。结果观察组患者治疗总有效率为94.5%,对照组为85.2%,观察组明显高于对照组,P<0.05,具有统计学意义;治疗前两组患者体温、C反应蛋白、白细胞、血沉、中性粒细胞均值无明显差异,治疗后均下降,下降幅度观察组明显高于对照组,P<0.05,具有统计学意义。结论氨溴索、布地奈德雾化吸入联合治疗慢支急性发作疗效显著,安全稳定。%ObjectiveTo study the effect of Ambroxol and Budesonide aerosol inhalation in treatment of acute exacerbation of chronic bronchitis. MethodsFrom October 2012 to September 2014 in our hospital, 108 cases of patients with acute attack of chronic bronchitis were divided into observation group and control group 54 cases, control group was treated with the conventional synthesis methods, observation group in the control group on the basis of the total ammonia bromine rope, combination treatment with budesonide atomization inhalation, observed and compared the therapeutic effect of two groups.Results The observation group of patients treatment the total effective rate was 94.5%, control group was 85.2%, the observation group is signiifcantly higher than the control group,P<0.05, there was statistically signiifcant. Two groups of patients before treatment temperature, c-reactive protein, white blood cells, blood sedimentation, neutrophils mean no signiifcant difference, decreased after treatment, the decline in observation group is significantly higher than the control group,P<0.05, with statistical

  11. 哌拉西林他唑巴坦治疗慢性支气管炎急性发作120例临床疗效观察%Piperacillin Tazobactam Treatment of Acute Exacerbation of Chronic Bronchitis, 120 Cases of Clinical Observation

    Institute of Scientific and Technical Information of China (English)

    高成兵; 汪平; 幸仕洪; 王珏

    2013-01-01

    目的:研究分析采用哌拉西林他唑巴坦治疗慢性支气管炎急性发作的临床措施和效果。方法回顾性分析2010年3月~2012年3月,我院收治的120例慢性支气管炎急性发作患者的临床资料,按照患者入院治疗的时间顺序将其随机分为两组,单号入院患者为观察组,共60例,采用哌拉西林他唑巴坦联合氨溴索治疗;双号入院患者为对照组,60例,采用氨苄西林联合氨溴索治疗。比较两组患者的临床疗效和各项临床症状缓解的时间。结果治疗后观察组患者的治疗有效率为96.67%,对照组患者的治疗有效率为86.67%,两组比较差异明显,具有统计学意义,(P<0.05);且观察组患者的各项临床症状的缓解时间短于对照组,两组比较差异明显,具有统计学意义,(P<0.05)。结论哌拉西林他唑巴坦是治疗慢性支气管炎急性发作的良好药物,临床疗效显著,安全性高,值得临床推广。%Objective: To study the methods and Effect of treating acute exacerbation of chronic bronchitis with piperacillin-tazobactam. Methods: Choosed 120 cases of acute exacerbation of chronic bronchitis to divide into study group and controlled group with 60 cases in each group. The study group were treated with piperacillin-tazobactam and ambroxol, the controlled group were treated with ampicillin and ambroxol. Compared the clinicallEffect and remission time. Results: The clinicallEffect of study group was 96.67%, higher than 86.67% of controlled group. And the remission time of study group was shorter than controlled group. Conclusion: Treating acute exacerbation of chronic bronchitis with piperacillin-tazobactam receive bet er Effects and high safety to extend in clinic.

  12. 阿奇霉素与左氧氟沙星治疗慢性支气管炎急性发作的疗效和安全性比较研究%Azithromycin and levofloxacin in treatment of acute exacerbations of chronic bronchitis curative effect and the security of the comparative study

    Institute of Scientific and Technical Information of China (English)

    王艳碧

    2012-01-01

      目的:探讨阿奇霉素与左氧氟沙星治疗慢性支气管炎急性发作的临床疗效.方法:本研究于2010年8月~2012年2月分别采用阿奇霉素和左氧氟沙星治疗慢性支气管炎急性发作患者,并对两种药物治疗的临床疗效和不良反应进行对比研究.结果:研研究组在用药3d、6d 及用药后1d 的临床总有效率与对照组相比较均无明显差异(P 均﹥0.05).研究组在治疗过程中出现1例恶心、胃部不舒服,1例头晕;对照组则在治疗过程中出现2例恶心、1例头晕.经对症治疗后症状均缓解,未影响治疗.结论:使用口服阿奇霉素5 d 与口服左氧氟沙星7 d 治疗慢性支气管炎急性发作均有较好的临床治疗效果,且安全性良好,值得临床推广使用.%  Objective: To investigate the azithromycin and levofloxacin in treatment of acute exacerbations of chronic bronchitis clinical curative effect. Methods: This study in 2010 August ~ 2012 year in February respectively with azithromycin and levofloxacin in the treatment of patients with acute exacerbations of chronic bronchitis, and two kinds of drugs for the treatment of clinical efficacy and adverse reaction were studied. Results: the research group at the 3D 6D medication, treatment and after 1D total clinical efficiency as compared with the control group showed no significant difference ( P al ﹥0.05). The study group emerged in the course of treatment in 1 cases of nausea, upset stomach, 1 cases of dizziness;while the control group emerged in the course of treatment in 2 cases, 1 cases of dizziness nausea. After the symptomatic treatment, symptoms were relieved in al patients, no impact. Conclusion: the use of oral azithromycin 5 d with oral levofloxacin in treatment of acute exacerbations of chronic bronchitis 7 d has good clinical curative effect, and good safety, is worthy of clinical use.

  13. 沙丁胺醇雾化吸入联合沉香饮加减治疗慢性喘息性支气管炎急性发作的疗效观察%Efficacy observation on treating acute exacerbation of chronic asthmatic bronchitis with the albuterol inhalation joint the Chenxiang decoction

    Institute of Scientific and Technical Information of China (English)

    潘君贤

    2012-01-01

      Objective:To analyze and investigate the clinical effect of treating acute exacerbation chronic asthmatic bronchitis with the albuterol inhalation of joint the Chenxiang decoction. Methods: Retrospective analyzing 20 patients with acute exacerbation of chronic asthmatic bronchitis in our hospital from January 2009 to December 2011, and plus salbutamol solution (1ml, 2 times a day) joint the Chenxiang decoction for treatment, in accordance with the evaluation standard, the analysis and observation of clinical efficacy in the treatment of this group of patients. Results: ①After treatment, markedly in 12 cases, effective in 7 cases, and ineffective in 1 case, the total effective rate of 95.0%. During treatment, symptoms of palpitations in 2 cases, 1 case of patient had symptoms of nausea, and adverse reactions disappear after medicine withdrawal. ②Pre-treatment lung function parameters (FEV1 and PEFR) were significantly lower than after treatment (2 weeks), and both showed a statistically significant difference. Conclusion:Treating acute exacerbation of chronic asthmatic bronchitis with the albuterol inhalation joint the Chenxiang decoction, its clinical efficacy, should be generalized and applied in clinical.%  目的:对沙丁胺醇雾化吸入联合沉香饮加减用于治疗慢性喘息性支气管炎的临床疗效进行分析与探究.方法:回顾性分析了2009年1月~2011年12月入住我院的20例慢性喘息性支气管炎急性发作的患者的临床资料,并向其加用沙丁胺醇雾化吸入溶液(1ml,每天2次)联合沉香饮加减饮进行治疗,按照相关的疗效评定标准,对本组患者在该种治疗方法下的临床疗效进行分析与观察.结果:①经过上述治疗方法的应用,显效例数12例,有效例数7例,无效例数为1例总有效率为95.0%.在治疗过程中,有2例出现心悸症状,1例出现恶心症状,停药之后不良反应均消失.②治疗前肺功能参数(FEV1与PEFR)要明显低

  14. Effect observation of salmeterol xinafoate and fluticasone propionate pow-der for inhalation in the treatment of acute attack of chronic bronchitis%沙美特罗替卡松粉吸入剂治疗慢性支气管炎急性发作的效果观察

    Institute of Scientific and Technical Information of China (English)

    肖亮

    2014-01-01

    目的:观察沙美特罗替卡松粉吸入剂治疗慢性支气管炎急性发作的临床效果。方法选取本院2012年2月~2014年2月收治的68例慢性支气管炎急性发作患者为研究对象,按照随机数字表法将其分为两组,各34例。对照组采取吸氧、平喘、抗感染、吸痰等常规治疗,实验组在对照组基础上加用沙美特罗替卡松粉吸入剂治疗,比较两组的治疗效果及不良反应情况。结果实验组中临床治愈19例(55.88%),显效8例(23.53%),好转5例(14.71%),总有效率为94.12%,对照组临床治愈14例(41.18%),显效8例(23.53%),好转3例(8.82%),总有效率为73.53%,实验组的总有效率明显高于对照组(P0.05)。结论沙美特罗替卡松粉吸入剂能明显改善临床症状,且不良反应少,值得在慢性支气管炎急性发作患者中进一步应用。%Objective To observe the clinical effect of salmeterol xinafoate and fluticasone propionate powder for in-halation in the treatment of acute attack of chronic bronchitis. Methods From February 2012 to February 2014,68 pa-tients with acute attack of chronic bronchitis admitted into our hospital were selected as research objects and they were evenly divided into two groups according to the random number table method.In the control group,regular treatment in-cluding oxygen uptake,anti-asthma,anti-infection,and aspiration of sputum were provided, while in the experimental group,on the basis of treatment the control group, salmeterol xinafoate and fluticasone propionate powder for inhalation was added. The clinical effect and adverse reaction in the two groups were compared. Results In the experimental group,19 cases (55.88%) were cured clinically,8 cases were markedly efective (23.53%),5 cases (14.71%) were improved, the total effective rate was 94.12%,while in the control group,14 cases (41.18%) were clinically cured,8 cases (23.53%) were markedly efective,3 cases (8.82%) were improved

  15. 负离子氧疗慢性支气管炎急性发作期的临床观察及感染控制对疗效的影响%Clinical observation on negative ion of oxygen therapy for patients with acute exacerbation of chronic ;bronchitis and the efifcacy of anti-infection measures

    Institute of Scientific and Technical Information of China (English)

    于德海

    2013-01-01

    目的:探讨高浓度负离子氧疗在慢性支气管炎急性发作期治疗中的临床应用价值。方法将本院收治的106例慢性支气管炎急性发作期患者随机分为观察组和对照组,每组患者53例。对照组给予常规西药治疗,观察组在对照组基础上给予高浓度负离子氧疗,观察两组的临床症状改善情况、肺功能改善情况、实验室生化指标及临床疗效。结果观察组临床总有效率为90.6%(48/53),对照组临床总有效率为73.5%(39/53),两组差异有统计学意义(P <0.05),观察组咳嗽、喘息及肺啰音等临床症状改善情况均显著优于对照组(P <0.05),观察组FEV1、FEV1/FVC、p(O2)及p(CO2)的肺功能各项指标改善情况显著优于对照组(P <0.05),观察组CRP、PCT及WBC等实验室生化指标也均显著优于对照组(P <0.05)。结论高浓度负离子氧疗能显著提高慢性支气管炎急性发作期的临床疗效,具有重要的临床应用价值。%Objective To explore clinical efifcacy of high concentration negative ions of oxygen therapy for patients with acute exacerbation of chronic bronchitis. Methods Total of 106 patients with acute exacerbation of chronic bronchitis were randomly divided into two groups with 53 cases in each group, the observation group treated with the conventional therapy plus adjuvant treatment of high concentration negative ions of oxygen were compared with the control group treated with conventional therapy. The clinical efifcacy of the two groups was observed. Results The clinical efifciency of the observation group was 90.6%, the clinical efifciency of the control group was 73.5%, the clinical symptoms and serum biochemical indicators of the observation group was signiifcantly better than that of the control group, with signiifcant difference (P<0.05). Conclusions High concentration negative ions of oxygen therapy can signiifcantly improve the clinical

  16. Role of PGE2 in Asthma and Nonasthmatic Eosinophilic Bronchitis

    Directory of Open Access Journals (Sweden)

    Beatriz Sastre

    2012-01-01

    Full Text Available Eosinophilic bronchitis is a common cause of chronic cough, which like asthma is characterized by sputum eosinophilia, but unlike asthma there is no variable airflow obstruction or airway hyperresponsiveness. Several studies suggest that prostaglandins may play an important role in orchestrating interactions between different cells in several inflammatory diseases such as asthma. PGE2 is important because of the multiplicity of its effects on immune response in respiratory diseases; however, respiratory system appears to be unique in that PGE2 has beneficial effects. We described that the difference in airway function observed in patients with eosinophilic bronchitis and asthma could be due to differences in PGE2 production. PGE2 present in induced sputum supernatant from NAEB patients decreases BSMC proliferation, probably due to simultaneous stimulation of EP2 and EP4 receptors with inhibitory activity. This protective effect of PGE2 may not only be the result of a direct action exerted on airway smooth-muscle proliferation but may also be attributable to the other anti-inflammatory actions.

  17. 9 CFR 113.327 - Bronchitis Vaccine.

    Science.gov (United States)

    2010-01-01

    ... respiratory signs or death shall be counted as failures. Two-stage sequential testing may be conducted if the.... Final container samples of completed product shall be tested for virus titer using the procedure... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Bronchitis Vaccine. 113.327...

  18. Acute Bronchitis - Multiple Languages: MedlinePlus

    Science.gov (United States)

    ... Somali) Bilingual PDF Health Information Translations Spanish (español) Bronquitis aguda Ukrainian (Українська) Bronchitis Бронхіт - Українська (Ukrainian) Bilingual ...

  19. Heterotypic protection to infectious bronchitis virus

    Science.gov (United States)

    We developed Newcastle disease virus (NDV) LaSota (rLS) expressing a distinct spike (S) protein gene of infectious bronchitis virus (IBV). This recombinant vaccine technology confers cross-protection among different IBV strains. We also experimentally demonstrated that the recombinant construct main...

  20. Role of P G E 2 in Asthma and Nonasthmatic Eosinophilic Bronchitis

    OpenAIRE

    Sastre, Beatriz; del Pozo, Victoria

    2012-01-01

    Eosinophilic bronchitis is a common cause of chronic cough, which like asthma is characterized by sputum eosinophilia, but unlike asthma there is no variable airflow obstruction or airway hyperresponsiveness. Several studies suggest that prostaglandins may play an important role in orchestrating interactions between different cells in several inflammatory diseases such as asthma. PGE2 is important because of the multiplicity of its effects on immune response in respiratory diseases; however, ...

  1. Comprehensive diagnosis and treatment of patients with deforming bronchitis

    International Nuclear Information System (INIS)

    A total of 1067 patients aged from 15 to 82 years who suffered from deforming bronchitis were examined. All the patients underwent X-ray examination, forced external respiration test, bronchofibroscopy with biopsy and radionuclide study of the lungs whose results were the basis for establishing a diagnosis of deforming bronchitis with an accuracy of 99,8%. Therapeutical bronchoscopies made in patients with deforming bronchitis were an effective therapeutical tool in 96,9-98,1% of cases

  2. Observation of the application effect of health education nursing intervention in elderly patients with chronic bronchitis%老年慢性支气管炎患者应用健康教育护理干预的效果观察

    Institute of Scientific and Technical Information of China (English)

    王晨英

    2015-01-01

    Objective:To explore the application effect of health education nursing intervention in elderly patients with chronic bronchitis.Methods:120 elderly patients with chronic bronchitis were selected.They were randomly divided into the control group and the observation group with 60 cases in each group.The control group was given routine nursing intervention,and the observation group was given nursing intervention of health education.Results:In the control group,23 cases(38.33%) changed their bad living habits,31 cases(51.67%) quitted smoking and drinking;in the observation group,50 cases(83.33%) changed their bad living habits,59 cases(98.33% ) quitted smoking and drinking,the different was statistically significant(P<0.05).In the control group,the average recurrence time was 115 days,average one treatment time was 12 days;in the observation group,the average recurrence time was 194 days,average one treatment time was 7 days.Conclusion:Health education nursing intervention had very good curative effect in clinic.It can shorten the course of treatment in patients,and delay patients recurrence time.%目的:探讨对老年慢性支气管炎患者应用健康教育护理干预的治疗效果。方法:收治老年慢性支气管炎患者120例,随机平均分为对照组和观察组,对照组采用常规护理干预,观察组采用健康教育护理干预。结果:对照组逐渐改变自己的生活习惯23例(38.33%),戒烟戒酒31例(51.67%);观察组改变自己不良的生活习惯50例(83.33%),戒烟戒酒59例(98.33%)。两组比较,差异有统计学意义(P<0.05)。对照组再次复发时间平均115 d,1个疗程时间平均12 d;观察组再次复发时间平均194 d,1个疗程时间平均7 d。结论:健康教育护理干预在临床上取得了非常好的疗效,可缩短患者的治疗时间,延缓患者的再次复发时间。

  3. 38 CFR 3.316 - Claims based on chronic effects of exposure to mustard gas and Lewisite.

    Science.gov (United States)

    2010-07-01

    ..., bronchitis, emphysema, asthma or chronic obstructive pulmonary disease. (3) Full-body exposure to nitrogen mustard during active military service together with the subsequent development of acute...

  4. Risco aumentado de sintomas respiratórios e bronquite crônica em mulheres que utilizam biocombustíveis na Nigéria Increased risk of respiratory symptoms and chronic bronchitis in women using biomass fuels in Nigeria

    Directory of Open Access Journals (Sweden)

    Olufemi Olumuyiwa Desalu

    2010-08-01

    Full Text Available OBJETIVO: Determinar a associação de sintomas respiratórios e bronquite crônica com o uso de biocombustíveis entre mulheres habitantes de áreas rurais do estado de Ekiti, sudoeste da Nigéria. MÉTODOS: De janeiro a junho de 2009, realizou-se um estudo transversal com uma amostra de 269 mulheres adultas. Um questionário adaptado do European Community Respiratory Health Survey foi aplicado para a obtenção de dados sobre características sociodemográficas, tipo de combustível utilizado para a preparação de alimentos, sintomas respiratórios e história de tabagismo. Todas as participantes foram convidadas a realizar espirometria. RESULTADOS: Das 269 mulheres no estudo, 161 (59,9% utilizavam biocombustíveis para a preparação de alimentos. As mulheres que utilizavam biocombustíveis relataram mais sintomas respiratórios que aquelas que não os utilizavam - tosse (13,7% vs. 3,7%; sibilância (8,7% vs. 2,8%; dor no peito (7,5% vs. 1,9%; falta de ar (11,8% vs. 6,5%; sintomas nasais (9,3% vs. 4,6%; e bronquite crônica (10,6% vs. 2,8%. A análise multivariada por regressão logística confirmou que o uso de biocombustíveis está associado às seguintes variáveis: tosse (OR = 4,82; p = 0,01; bronquite crônica (OR = 3,75; p = 0,04; sibilância (OR = 2,22; p = 0,23; dor no peito (OR = 3,82; p = 0,09; falta de ar (OR = 1,54; p = 0,35; e sintomas nasais (OR = 2,32; p = 0,20. Todos os parâmetros espirométricos avaliados (VEF1, CVF, VEF1/CVF e PFE foram menores nas mulheres que utilizavam biocombustíveis do que naquelas que não os utilizavam. CONCLUSÕES: Nossos resultados enfatizam a necessidade de se substituir o uso de biocombustíveis nos domicílios pelo de um tipo de combustível atóxico, como eletricidade ou gás.OBJECTIVE: To determine whether respiratory symptoms and chronic bronchitis are associated with the use of biomass fuels (BMFs among women residing in rural areas of the Ekiti State, in southwestern Nigeria. METHODS

  5. Pulmonary artery radiocardiography and rheography in the diagnosis of hemodynamic and contractile function impairments of the right ventricle in patients with obstructive bronchitis

    International Nuclear Information System (INIS)

    Radiocardiography and rheography of the pulmonary artery were used to examine impairments in hemodynamics and contractile function of the right ventricle in 40 patients with chronic obstructive bronchitis complicated with persistent hypertension. Right ventricular hemodynamic and contractile impairments were shown to be not equivalent with similar clinical and functional signs of pulmonary hypertension. This fact indicates that the use of special techiques is of practical value in the determination of right ventricular hemodynamics and myocardial contractility in patients with chronic obstructive bronchitis. Radiocardiography and rheography of the pulmonary artery are sufficiently reliable noninvasive techniques for examining the hemodynamics and contractile function of the right ventricular myocardium

  6. Infectious Bronchitis Vaccination Protocols for Laying Hens

    OpenAIRE

    A. Sulaiman; Roberts, J.R.

    2011-01-01

    A research was conducted to investigate the effects of vaccination protocols for Infectious Bronchitis (IB) on egg production, egg quality, and IB antibody titres of laying hens. Different initial vaccination (Control, VicS eye, VicS spray, VicS water, A3 eye, A3 spray, and A3 water) for IB were administered to day-old Isa Brown hens. Half the hens were revaccinated regularly during lay whereas the other hens were not vaccinated. Results showed that initial vaccination treatment had signific...

  7. Plastic Bronchitis in a Child Presenting as Surgical Emphysema

    Directory of Open Access Journals (Sweden)

    Nikita Tripathi

    2015-12-01

    Full Text Available Plastic bronchitis (PB refers to the presence of inspissated Bronchial casts (BC is uncommon in children.Our case presented with subcutaneous emphysema as the dominant manifestation and was suspected to have foreign body in airway, but bronchoscopy revealed a bronchial cast. Subcutaneous emphysema as the initial/sole manifestation of plastic bronchitis is very rare in children.

  8. Acupuncture as method of treatment and arresting progress of dust-induced bronchitis

    Energy Technology Data Exchange (ETDEWEB)

    Baburina, E.B.; Bykova, E.A.

    1983-10-01

    Acupuncture is an effective therapy for treatment of dust-induced bronchitis. It can be used independently or in combination with medicaments. Fifty men were divided into two groups of 20 and 30. One group was treated by acupuncture alone, the other with combined therapy. Acupuncture produced excellent results; combined treatment, good and satisfactory results. Since acupuncture reduced the possibility of complications, allergic reactions and side effects due to medication, it is an excellent means of preventing progress of dust-induced bronchitis. Patients experience 9 months remission of symptoms after treatment with acupuncture while medical therapy alone only relieves them for 1 to 1 1/2 months. Patients with chronic dust-induced bronchitis should receive a second course of acupuncture in 6 to 8 months to prevent recurrence of symptoms and progress of disease. Because of insufficient study of lasting effects of acupuncture, final conclusions about its effectiveness cannot be made, however, current evidence indicates it is a highly useful therapy. 6 references.

  9. Vascular endothelial growth factor as a non-invasive marker of pulmonary vascular remodeling in patients with bronchitis-type of COPD

    Directory of Open Access Journals (Sweden)

    Nomura Saeko

    2007-03-01

    Full Text Available Abstract Background Several studies have indicated that one of the most potent mediators involved in pulmonary vascular remodeling is vascular endothelial growth factor (VEGF. This study was designed to determine whether airway VEGF level reflects pulmonary vascular remodeling in patients with bronchitis-type of COPD. Methods VEGF levels in induced sputum were examined in 23 control subjects (12 non-smokers and 11 ex-smokers and 29 patients with bronchitis-type of COPD. All bronchitis-type patients performed exercise testing with right heart catheterization. Results The mean pulmonary arterial pressure (mPAP and pulmonary vascular resistance (PVR after exercise were markedly increased in all bronchitis-type patients. However, both parameters after exercise with breathing of oxygen was significantly lower than in those with breathing of room air. To attenuate the effect of hypoxia-induced pulmonary vasoconstriction during exercise, we used the change in mPAP or PVR during exercise with breathing of oxygen as a parameter of pulmonary vascular remodeling. Change in mPAP was significantly correlated with VEGF level in induced sputum from patients with chronic bronchitis (r = 0.73, p = 0.0001. Moreover, change in PVR was also correlated with VEGF level in those patients (r = 0.57, p = 0.003. Conclusion A close correlation between magnitude of pulmonary hypertension with exercise and VEGF level in bronchitis-type patients could be observed. Therefore, these findings suggest the possibility that VEGF level in induced sputum is a non-invasive marker of pulmonary vascular remodeling in patients with bronchitis-type of COPD.

  10. Comparison of airway immunopathology of eosinophilic bronchitis and asthma

    OpenAIRE

    Brightling, C.; Symon, F; Birring, S; Bradding, P; Wardlaw, A; PAVORD, I

    2003-01-01

    Methods: Exhaled nitric oxide was measured and induced sputum, bronchoscopy, bronchial wash (BW), bronchoalveolar lavage (BAL), and bronchial biopsy were performed in 16 subjects with eosinophilic bronchitis, 15 with asthma, and 14 normal controls.

  11. Living Well with COPD: Chronic Bronchitis and Emphysema

    Science.gov (United States)

    ... the airways • These are not the same as anabolic steroids,which are muscle-building steroids often misused by ... not to be confused Air sacs (alveoli) with anabolic steroids used by athletes and others to build muscles. ...

  12. Molecular mechanisms of recurrent acute obstructive bronchitis in infants

    Directory of Open Access Journals (Sweden)

    Abaturov A.E.

    2015-06-01

    Full Text Available The article discusses the clinical and immunological features and mechanisms of recurrent acute obstructive bronchitis in infants. We have examined 102 children aged from 6 months to 3 years with acute obstructive bronchitis and signs of respiratory insufficiency of the I-II degree. There were 28 children with recurrent acute obstructive bronchitis and 74 patients with acute obstructive bronchitis,developed for the first time. We determined the concentration of total IgE, content of IFN-і, IL-4, IL-12 and IL-13 in serum by ELISA and the expression of the transcription factor NF-єB in lymphocytes of peripheral blood by flow cytometry in all the children. High level of IL-12 as compared to physiological norms in the dynamics of the disease was the characteristic feature of the children of both groups. And it was the factor, which detected a voltage of cell-mediated immune response and inflammation. The second specific feature was the high concentration of IgE. It was shown that the transcription factor NF-єB determined the cytokine status at the beginning of the disease, and in the period of convalescence. That fact did not depend on the number of previous acute obstructive bronchitis. However, there were violations of the mechanisms of NF-єB-associated signaling pathways activation, which manifested itself in an advantageous enhancement of the chains, determining the production of Th2-associated cytokines in children with recurrent acute obstructive bronchitis.

  13. Clinicoroentgenological control in chronic pneumonia

    International Nuclear Information System (INIS)

    A comprehensive clinicoroentgenological study was used to examine 494 patients with chronic pneumonia. Morphological and functional changes observed in the pulmonary pare and functional changes observed in the pulmonary parenchyma and bronchial tree were studied. Types of pneumosclerosis, tigns of exacerbation of chronic pneumonia and abscess formation, morphological and functional disorders of bronchial penetrability in the pneumonic zone were described. Three forms of chronic pneumonia: bronchial, bronchiectatic and abscessing are signled out. The bronchial form is subdivided into chronic pneumonia with chronic bronchitis without deformity and wi.th deforming chronic bronchitis. In the bronchiectatic form pneumonia can be with cylindrical, saccular and cyst-like bronchiectasia. The general diagnosis of chronic pneumonia is established clinically depending on type and variants in 89-94% of cases, by X-ray and sonographic findings in all patients; types and variants of disease are most frequently defined after bronchography

  14. Infectious Bronchitis Vaccination Protocols for Laying Hens

    Directory of Open Access Journals (Sweden)

    A. Sulaiman

    2011-12-01

    Full Text Available A research was conducted to investigate the effects of vaccination protocols for Infectious Bronchitis (IB on egg production, egg quality, and IB antibody titres of laying hens. Different initial vaccination (Control, VicS eye, VicS spray, VicS water, A3 eye, A3 spray, and A3 water for IB were administered to day-old Isa Brown hens. Half the hens were revaccinated regularly during lay whereas the other hens were not vaccinated. Results showed that initial vaccination treatment had significant effects on hen day egg production and egg quality of egg weight, shell reflectivity, shell breaking strength, shell thickness, albumen height, Haugh Units, and IB antibody titre levels, but had no effect on percentage of shell and yolk colour. Egg weight and shell reflectivity were less favourable in the control hens. In contrast, shell breaking strength and shell thickness were highest for the group that initially received A3 vaccine in water. However, regular revaccination had some deleterious effects on egg production and egg quality. There were no significant effects of revaccination on IB antibody titres. It is concluded that there was little advantage in regularly revaccinating laying hens for IB virus, since they had received appropriate initial vaccination.

  15. Etiology and immunology of infectious bronchitis virus

    Directory of Open Access Journals (Sweden)

    LF Caron

    2010-06-01

    Full Text Available Infectious bronchitis virus (IBV of chickens is currently one of the main diseases associated with respiratory syndrome in domestic poultry, as well as with losses related to egg production. The etiological agent is a coronavirus, which presents structural differences in the field, mainly in the S1 spike protein. The immune response against this virus is complicated by the few similarities among serotypes. Environmental and management factors, as well as the high mutation rate of the virus, render it difficult to control the disease and compromise the efficacy of the available vaccines. Bird immune system capacity to respond to challenges depend on the integrity of the mucosae, as an innate compartment, and on the generation of humoral and cell-mediated adaptive responses, and may affect the health status of breeding stocks in the medium run. Vaccination of day-old chicks in the hatchery on aims at eliciting immune responses, particularly cell-mediated responses that are essential when birds are first challenged. Humoral response (IgY and IgA are also important for virus clearance in subsequent challenges. The presence of antibodies against the S1 spike protein in 3- to 4-week-old birds is important both in broilers and for immunological memory in layers and breeders.

  16. Early History of Chronic Obstructive Pulmonary Disease 1808-1980.

    Science.gov (United States)

    Watson, R Ann; Pride, Neil B

    2016-04-01

    COPD has become a more popular research area in the last 3 decades, yet the first clear descriptions of acute and chronic bronchitis were in 1808. This brief history, comprehensively referenced, leads us through the early developments in respiratory physiology and their applications. It emphasises the early history of chronic bronchitis and emphysema in the 19(th) and early 20(th) centuries, long before the dominant effects of cigarette smoking emerged. This remains relevant to developing countries today. PMID:26418529

  17. Cerebral Lipiodol Embolism after Lymphatic Embolization for Plastic Bronchitis.

    Science.gov (United States)

    Kirschen, Matthew P; Dori, Yoav; Itkin, Maxim; Licht, Daniel J; Ichord, Rebecca; Vossough, Arastoo

    2016-09-01

    An adolescent with plastic bronchitis due to congenital heart disease had altered mental status after an interventional lymphatic procedure in which lipiodol contrast was used. Neuroimaging revealed cerebral lipiodol embolization due to direct shunting between lymphatic channels and pulmonary veins. Cerebral lipiodol embolization is a potential neurologic morbidity associated with interventional lymphatic procedures. PMID:27297208

  18. Radiation bronchitis in lung cancer patient treated with stereotactic radiation therapy

    International Nuclear Information System (INIS)

    We report a case of chronic radiation bronchitis that developed in a patient with lung cancer treated with fractionated stereotactic radiation therapy. A 73-year-old woman with a medically inoperable T1N0M0 adenocarcinoma of the lung was treated with stereotactic radiation therapy. By using eight non-coplanar ports, 50 Gy/5 fractions was delivered in two weeks. At four weeks, a partial response was obtained with no acute adverse reaction. She developed severe cough at six months. Fiberoptic bronchoscopy revealed thick circumferentially coated bronchial mucosa in close proximity to the tumor site. At 12 months, follow-up study confirmed marked stenotic change in the B6 segmental bronchus without tumor progression. (author)

  19. Prevalence of chronic conditions – Chronic Airflow Obstruction

    OpenAIRE

    Ireland and Northern Ireland Population Health Observatory (INIsPHO)

    2012-01-01

    IPH has estimated and forecast clinical diagnosis rates of CAO among adults for the years 2010, 2015 and 2020. In the Republic of Ireland, the data are based on the Survey of Lifestyle, Attitudes and Nutrition (SLÁN) 2007. The data describe the number of people who report that they have experienced doctor-diagnosed chronic bronchitis, chronic obstructive lung (pulmonary) disease, or emphysema in the previous 12 months (annual clinical diagnosis). Data is available by age and sex for each Loca...

  20. Avian infectious bronchitis virus in Africa: a review.

    Science.gov (United States)

    Khataby, Khadija; Fellahi, Siham; Loutfi, Chafiqa; Mustapha, Ennaji Moulay

    2016-06-01

    Infectious bronchitis virus (IBV) is worldwide in distribution, highly infectious, and extremely difficult to control because it has extensive genetic diversity, a short generation time, and a high mutation rate. IBV is a Gammacoronavirus, single-stranded, and positive-sense RNA virus. Avian infectious bronchitis is well studied in European countries with identification of a large number of IBV variants, whereas in African countries epidemiological and scientific data are poor and not updated. However, previous studies reported that an IBV variant continues to appear regularly in Africa, as currently described in Morocco. No cross-protection between IBV strains was reported, some being unique to a particular country, others having a more general distribution. This review aims to provide a general overview on IB disease distribution in African countries and an update on the available studies of IBV variants in each country. PMID:27150555

  1. Cystic fibrosis transmembrane conductance regulator gene abnormalities in patients with asthma and recurrent neutrophilic bronchitis

    OpenAIRE

    Jodi Goodwin; Naomi Spitale; Asma Yaghi; Myrna Dolovich; Parameswaran Nair

    2012-01-01

    The present case series describes four patients with asthma, airway hyper-responsiveness and neutrophilic bronchitis who harboured abnormal cystic fibrosis transmembrance conductance regulator (CFTR) gene mutations. It serves both to alert clinicians to consider CFTR-related disease in both young and elderly patients with persistent neutrophilic bronchitis, and to highlight the potential utility of future genetic testing for CFTR abnormalities in patients with asthma and recurrent bronchitis ...

  2. Relation between Ascites Syndrome Incidence and Infectious Bronchitis in Broiler Chickens by ELISA Method

    OpenAIRE

    Adel Feizi; Mehrdad Nazeri

    2011-01-01

    Infectious bronchitis is an acute viral disease with high contagious and mortality among chicks. The aim of this study was to survey of relation between ascites syndrome incidence and infectious bronchitis in broiler chickens by ELISA method in Iran. Eight Ross strain broiler farm affected by infectious bronchitis were selected in this study. Blood samples were gathered early stages of disease and blood sampling was repeated two times with seven days interval. ELISA serologic test was used fo...

  3. Avian infectious bronchitis virus in Brazil: a highly complex virus meets a highly susceptible host population

    Directory of Open Access Journals (Sweden)

    PE Brandão

    2010-06-01

    Full Text Available Infectious bronchitis (IB is a highly aggressive disease for poultry in terms of symptoms and economic losses, and the control of this disease is difficult if flocks are not protected against type-specific challenges by the Avian infectious bronchitis virus (IBV. This article summarizes data presented by the author at the Workshop on Infectious Bronchitis 2009 on IB and IBV, including future developments on the field.

  4. Comorbidity between chronic obstructive pulmonary disease and type 2 diabetes

    DEFF Research Database (Denmark)

    Meteran, Howraman; Backer, Vibeke; Kyvik, Kirsten Ohm; Skytthe, Axel; Thomsen, Simon Francis

    2015-01-01

    the relationship between type 2 diabetes and chronic bronchitis and COPD in adult twins, and to examine to what extent comorbidity between these diseases is explained by shared genetic or environmental factors. METHODS: Questionnaire data on chronic bronchitis and hospital discharge data on diagnosed...... COPD in 13,649 twins, aged 50-71 years, from the Danish Twin Registry were cross-linked with hospital discharge diagnosis data on type 2 diabetes from the Danish National Patient Registry. RESULTS: The risk of type 2 diabetes was higher in persons with symptoms of chronic bronchitis than in those...... on chronic bronchitis and type 2 diabetes, and between genetic effects on diagnosed COPD and type 2 diabetes, respectively, were 0.33 (0.00-0.79), p = 0.103, and 0.43 (0.00-0.98), p = 0.154. Non-shared environmental correlations between chronic bronchitis and type 2 diabetes were -0.13 (-0.43 to 0...

  5. β-Blockers and All-Cause Mortality in Adults with Episodes of Acute Bronchitis: An Observational Study.

    Directory of Open Access Journals (Sweden)

    Frans H Rutten

    Full Text Available Recent observational studies suggest that β-blockers may improve long-term prognosis in patients with chronic obstructive pulmonary disease (COPD. We assessed whether β-blocker use improves all-cause mortality in patients with episodes of acute bronchitis.An observational cohort study using data from the electronic medical records of 23 general practices in the Netherlands. The data included standardized information about daily patient contacts, diagnoses, and drug prescriptions. Cox regression was applied with time-varying treatment and covariates.The study included 4,493 patients aged 45 years and older, with at least one episode of acute bronchitis between 1996 and 2006. The mean (SD age of the patients was 66.9 (11.7 years, and 41.9% were male. During a mean (SD follow up period of 7.7 (2.5 years, 20.4% developed COPD. In total, 22.7% had cardiovascular comorbidities, resulting in significant higher mortality rates than those without (51.7% vs. 12.0%, p<0.001. The adjusted hazard ratio of cardioselective β-blocker use for mortality was 0.62 (95% confidence interval [CI], 0.50-0.77, and 1.01 (95% CI 0.75-1.36 for non-selective ones. Some other cardiovascular drugs also reduced the risk of mortality, with adjusted HRs of 0.60 (95% CI 0.46-0.79 for calcium channel blockers, 0.88 (95% CI 0.73-1.06 for ACE inhibitors/angiotensin receptor blockers, and 0.42 (95% CI 0.31-0.57 for statins, respectively.Cardiovascular comorbidities are common and increase the risk of mortality in adults with episodes of acute bronchitis. Cardioselective β-blockers, but also calcium channel blockers and statins may reduce mortality, possibly as a result of cardiovascular protective properties.

  6. Lung scintigraphy in the assessment of recurrent bronchitis and pneumonia in children

    International Nuclear Information System (INIS)

    Recurrent bronchitis and pneumonia in childhood are a significant factor in predisposing adults to chronic respiratory disease. Lung scintigraphy in children with recurrent respiratory problems very frequently shows regional abnormalities, even in the absence of radiological sings. Structural changes, also at the histological level, are accompanied bu functional disturbances that cause lung scan abnormalities to become stable with time and are very likely responsible for persisting disease in adulthood. Moreover, any chronic respiratory condition that has been diagnosed,like cystic-fibrosis, bronchiectasis, bronchopulmonary malformations, lung fibrosis, should be assessed and followed-up by means of lung scintigraphy. Suspected radio transparent foreign-body inhalation, radiographical hypernucleus (compensatory or pathological emphysema?), functional assessment before lung surgery, suspected mucociliary function impairment, suspected interstitial pneumonia, all of the above conditions represent important indications to lung scintigraphy in children. Finally, it is wise pointing out that, in order to avoid false positive results towards the diagnosis of structural disease, any easily reversible functional impairment should be removed before the scan, by proper patient preparation: in children this is done by at least aerosol therapy with beta-agonists, local steroids and mucolytics for 1 week - 10 days

  7. E Protein Prokaryotic Expression of Avian Infectious Bronchitis Virus

    Institute of Scientific and Technical Information of China (English)

    WEI Ping; ZHANG Fang; MING Xiaobo; ZENG Xiangwei; ZHU Yuqing; WANG Lin

    2008-01-01

    The small envelope protein (E) gene of avian infectious bronchitis virus (IBV) M41 strain was cloned,and then it was subeloned into prokaryotic expressing vector pGEX-6P-1.The recombinant plasmid was transformed into E.coli.BL21 and induced by IPTG.SDS-PAGE result showed that when objective protein fused with GST (about 20 ku), the relative molecular mass of fusion protein was 38 ku.It indicated that objective protein was about 12.4 ku.The result showed that E protein was expressed successfully, it was useful to the subsequent E protein research.

  8. Recurrent Plastic Bronchitis in a Child with 2009 Influenza A (H1N1) and Influenza B Virus Infection

    OpenAIRE

    Kim, Sun; Cho, Hwa Jin; Han, Dong Kyun; Choi, Yoo Duk; Yang, Eun Seok; Cho, Young Kuk; Ma, Jae Sook

    2012-01-01

    Plastic bronchitis is an uncommon disorder characterized by the formation of bronchial casts. It is associated with congenital heart disease or pulmonary disease. In children with underlying conditions such as allergy or asthma, influenza can cause severe plastic bronchitis resulting in respiratory failure. A review of the literature showed nine cases of plastic bronchitis with H1N1 including this case. We report a case of a child with recurrent plastic bronchitis with eosinophilic cast assoc...

  9. Barotrauma as aetiological cascade of fatal intrapulmonary plastic bronchitis in a post-Fontan child

    OpenAIRE

    Elahi, Maqsood; Poh, Chin-Leng; Ravindranathan, Hari; Grant, Peter

    2012-01-01

    The role of barotrauma in the exaggeration of plastic bronchitis after Fontan circulation has yet to be examined. We aim to describe a case of a 4-year old post-Fontan circulation girl where barotrauma suffered during commercial air travel played a role in the aetiological cascade of plastic bronchitis.

  10. Pathogenesis and Diagnostic Approaches of Avian Infectious Bronchitis

    Directory of Open Access Journals (Sweden)

    Faruku Bande

    2016-01-01

    Full Text Available Infectious bronchitis (IB is one of the major economically important poultry diseases distributed worldwide. It is caused by infectious bronchitis virus (IBV and affects both galliform and nongalliform birds. Its economic impact includes decreased egg production and poor egg quality in layers, stunted growth, poor carcass weight, and mortality in broiler chickens. Although primarily affecting the respiratory tract, IBV demonstrates a wide range of tissues tropism, including the renal and reproductive systems. Thus, disease outcome may be influenced by the organ or tissue involved as well as pathotypes or strain of the infecting virus. Knowledge on the epidemiology of the prevalent IBV strains in a particular region is therefore important to guide control and preventions. Meanwhile previous diagnostic methods such as serology and virus isolations are less sensitive and time consuming, respectively; current methods, such as reverse transcription polymerase chain reaction (RT-PCR, Restriction Fragment Length Polymorphism (RFLP, and sequencing, offer highly sensitive, rapid, and accurate diagnostic results, thus enabling the genotyping of new viral strains within the shortest possible time. This review discusses aspects on pathogenesis and diagnostic methods for IBV infection.

  11. Preliminary crystallographic analysis of avian infectious bronchitis virus main protease

    International Nuclear Information System (INIS)

    The avian infectious bronchitis virus main protease has been crystallized; crystals diffract to 2.7 Å resolution. Infectious bronchitis virus (IBV) is the prototype of the genus Coronavirus. It causes a highly contagious disease which affects the respiratory, reproductive, neurological and renal systems of chickens, resulting great economic losses in the poultry industry worldwide. The coronavirus (CoV) main protease (Mpro), which plays a pivotal role in viral gene expression and replication through a highly complex cascade involving the proteolytic processing of replicase polyproteins, is an attractive target for antiviral drug design. In this study, IBV Mpro was overexpressed in Escherichia coli. Crystals suitable for X-ray crystallography have been obtained using microseeding techniques and belong to space group P6122. X-ray diffraction data were collected in-house to 2.7 Å resolution from a single crystal. The unit-cell parameters were a = b = 119.1, c = 270.7 Å, α = β = 90, γ = 120°. Three molecules were predicted to be present in the asymmetric unit from a calculated self-rotation function

  12. Natural Histories of Chronic Obstructive Pulmonary Disease

    OpenAIRE

    Rennard, Stephen I.; Vestbo, Jørgen

    2008-01-01

    Concepts relating to the natural history of chronic obstructive pulmonary disease (COPD) arise most importantly from the classic study of Fletcher and colleagues (The Natural History of Chronic Bronchitis and Emphysema, Oxford University Press, New York, 1976). This study, which evaluated working English men over 8 years, was used to construct a proposed life-long natural history. Although this is a classic study that has greatly advanced understanding of COPD, it has a number of limitations....

  13. Relation between Ascites Syndrome Incidence and Infectious Bronchitis in Broiler Chickens by ELISA Method

    Directory of Open Access Journals (Sweden)

    Adel Feizi

    2011-12-01

    Full Text Available Infectious bronchitis is an acute viral disease with high contagious and mortality among chicks. The aim of this study was to survey of relation between ascites syndrome incidence and infectious bronchitis in broiler chickens by ELISA method in Iran. Eight Ross strain broiler farm affected by infectious bronchitis were selected in this study. Blood samples were gathered early stages of disease and blood sampling was repeated two times with seven days interval. ELISA serologic test was used for approving the determination of infectious bronchitis. In addition, in order to differential diagnosis of Newcastle and influenza (H9N2 some relevant experiments were conducted. The rate of mortality in any farm during rearing, autopsy and the cause of mortality were recorded. Ascites cases were calculated in terms of prevalence. The growth parameters, FCR, final weight, total consumption of grain at each farm were calculated and mentioned. Based on obtained results in this study, the mean rate of mortality caused by ascites syndrome has been increased meaningfully in herds affected by infectious bronchitis compared with control group. In eight understudied farms affected by infectious bronchitis, the mean rate of Ascites mortality was 3% such that the mean rate of Ascites mortality was 0.5% at previous periods. Based on relevant results also final weight mean in affected herds with infectious bronchitis was lower compared with previous periods. Meanwhile, FCR in affected herds with infectious bronchitis was high compared with healthy herds. In this research demonstrated that there is positive correlation between infectious bronchitis and Ascites syndrome and the correlation is significant (p<0.05.

  14. Impact of Ambient Air Pollution on the Differential White Blood Cell Count in Patients with Chronic Pulmonary Disease

    OpenAIRE

    Brüske, Irene; Hampel, Regina; Socher, Martin M.; Rückerl, Regina; Schneider, Alexandra; Heinrich, Joachim; Oberdörster, Günter; Wichmann, H.-Erich; Peters, Annette

    2010-01-01

    Epidemiologic studies report associations between particulate air pollution and increased mortality from pulmonary diseases.To examine whether the exposure to ambient gaseous and particulate air pollution leads to an alteration of the differential white blood cell count in patients with chronic pulmonary diseases like chronic bronchitis, chronic obstructive pulmonary disease, and asthma.

  15. Regional perfusion of the lungs in patients with chronic nonspecific pulmonary diseases based on scintigraphy data

    International Nuclear Information System (INIS)

    Perfusion scintigraphy of lungs with 99mTc-albumin microspheres was used for a study of changes of regional perfusion of lesser circulation in patients with chronic bronchitis of a varying degree of disturbed pulmonary hemodynamics. Even before a stable rise of pulmonary vascular resistance and developmemt of pulmonary arterial hypertension, chronic bronchitis was characterized by redistribution of blood flow from the lower parts of lungs to the upper ones, which progressed with disturbance of pulmonary arterial circulation and the development of chronic cor pulmonale. The use of scintigraphic indices of the upper and lower parts (U/L) prefusion ratio led to adequate assessment of a degree of redistribution of the pulmonary blood flow in patients with chronic bronchitis

  16. Recombinant duck enteritis viruses expressing major structural proteins of the infectious bronchitis virus provide protection against infectious bronchitis in chickens.

    Science.gov (United States)

    Li, Huixin; Wang, Yulong; Han, Zongxi; Wang, Yu; Liang, Shulin; Jiang, Lu; Hu, Yonghao; Kong, Xiangang; Liu, Shengwang

    2016-06-01

    To design an alternative vaccine for control of infectious bronchitis in chickens, three recombinant duck enteritis viruses (rDEVs) expressing the N, S, or S1 protein of infectious bronchitis virus (IBV) were constructed using conventional homologous recombination methods, and were designated as rDEV-N, rDEV-S, and rDEV-S1, respectively. Chickens were divided into five vaccinated groups, which were each immunized with one of the rDEVs, covalent vaccination with rDEV-N & rDEV-S, or covalent vaccination with rDEV-N & rDEV-S1, and a control group. An antibody response against IBV was detectable and the ratio of CD4(+)/CD8(+) T-lymphocytes decreased at 7 days post-vaccination in each vaccinated group, suggesting that humoral and cellular responses were elicited in each group as early as 7 days post-immunization. After challenge with a homologous virulent IBV strain at 21 days post-immunization, vaccinated groups showed significant differences in the percentage of birds with clinical signs, as compared to the control group (p < 0.01), as the two covalent-vaccination groups and the rDEV-S group provided better protection than the rDEV-N- or rDEV-S1-vaccinated group. There was less viral shedding in the rDEV-N & rDEV-S- (2/10) and rDEV-N & rDEV-S1- (2/10) vaccinated groups than the other three vaccinated groups. Based on the clinical signs, viral shedding, and mortality rates, rDEV-N & rDEV-S1 covalent vaccination conferred better protection than use of any of the single rDEVs. PMID:26946113

  17. Crystallization and preliminary X-ray diffraction studies of infectious bronchitis virus nonstructural protein 9

    OpenAIRE

    Ma, Yanlin; Chen, Cheng; Wei, Lei; Yang, Qingzhu; Liao, Ming; Li, Xuemei

    2010-01-01

    The gene segment encoding avian infectious bronchitis virus nonstructural protein 9 has been cloned and expressed in Escherichia coli. The protein has been crystallized and the crystals diffracted X-rays to 2.44 Å resolution.

  18. Pseudomembranous aspergillus bronchitis in a double-lung transplanted patient: unusual radiographic and CT features

    International Nuclear Information System (INIS)

    Pseudomembranous aspergillus bronchitis is considered as an early form of invasive pulmonary aspergillosis, a well-known airway infection in immunocompromised patients. Radiologic features concerning invasive aspergillosis of the airways have been reported. However, we describe here an unusual feature of invasive aspergillus bronchitis, never reported to date, observed in a double-lung transplanted patient. Chest radiograph and CT revealed significant peribronchial thickening without any parenchymal involvement. (orig.)

  19. Purine Bases in Blood Plasma of Patients with Chronic Pulmonary Diseases

    Directory of Open Access Journals (Sweden)

    Larissa E. Muravluyova

    2012-09-01

    Full Text Available The article is focused on the study of purine bases and intermediates of purine catabolism in plasma of patients with chronic obstructive bronchitis and idiopathic interstitial pneumonia. Decrease of adenine and hypoxantine in plasma of patients with idiopathic interstitial pneumonia was registered. Increase of guanine in plasma of patients with chronic obstructive pulmonary disease was established.

  20. Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control study.

    Directory of Open Access Journals (Sweden)

    Jill Koshiol

    Full Text Available BACKGROUND: Chronic obstructive pulmonary disease (COPD has been consistently associated with increased risk of lung cancer. However, previous studies have had limited ability to determine whether the association is due to smoking. METHODOLOGY/PRINCIPAL FINDINGS: The Environment And Genetics in Lung cancer Etiology (EAGLE population-based case-control study recruited 2100 cases and 2120 controls, of whom 1934 cases and 2108 controls reported about diagnosis of chronic bronchitis, emphysema, COPD (chronic bronchitis and/or emphysema, or asthma more than 1 year before enrollment. We estimated odds ratios (OR and 95% confidence intervals (CI using logistic regression. After adjustment for smoking, other previous lung diseases, and study design variables, lung cancer risk was elevated among individuals with a history of chronic bronchitis (OR = 2.0, 95% CI = 1.5-2.5, emphysema (OR = 1.9, 95% CI = 1.4-2.8, or COPD (OR = 2.5, 95% CI = 2.0-3.1. Among current smokers, association between chronic bronchitis and lung cancer was strongest among lighter smokers. Asthma was associated with a decreased risk of lung cancer in males (OR = 0.48, 95% CI = 0.30-0.78. CONCLUSIONS/SIGNIFICANCE: These results suggest that the associations of personal history of chronic bronchitis, emphysema, and COPD with increased risk of lung cancer are not entirely due to smoking. Inflammatory processes may both contribute to COPD and be important for lung carcinogenesis.

  1. Spirometric controlled quantitative CT for chronic obstructive lung disease

    International Nuclear Information System (INIS)

    Objective: To analyze the mean lung density (MLD) and pixel index (PI) of emphysema and chronic bronchitis using spirometric controlled quantitative CT. Methods: Forty healthy adults, 23 patients with emphysema, and 15 patients with chronic bronchitis performed lung spiral scans at 50% vital capacity (VC), and HRCT sections were acquired at carina and carina +- 5 cm at 10% VC and 90% VC. Results: At 10% VC, the MLD in patients with emphysema and chronic bronchitis decreased (the MLD were -831.8 HU and -796.8 HU, respectively) compared to healthy adults (-745.3 HU) (P < 0.01). At 90% VC, only the MLD in patients with emphysema significantly decreased (P < 0.05). PI had the same feature as MLD, but it increased. The lesions detected by quantitative CT were consistent with that demonstrated by morphology. Quantitative CT was more sensitive than PFTs. The quantitative parameters of 10% VC could detect chronic bronchitis even when CT indicated normal results. Conclusion: The combination of CT and quantitative CT can accomplish the unity of morphology and function, thus offer more diagnostic clues and make the diagnosis perfect

  2. The Relationships Between Weather and Climate and Attacks of Bronchitis

    Science.gov (United States)

    Talaia, M. A. R.; Saraiva, M. A. C.; Vieira da Cruz, A. A.

    The area of Aveiro, more concretely Aveiro lagoon, a natural laboratory has been con- sidered, for promoting the development and the application of several investigations worked. The importance of the influences of weather and climate on human health has been well known since ancient teams and many decisions concerning human be- haviour it are clearly weather related. However, decisions related to weather criteria can be important and economically significant, but the real economic effect of the weather is difficult to assess. Talaia et al. (2000) and Talaia and Vieira da Cruz (2001) have shown the possible harmful effect of certain meteorological factors on respiratory conditions. Bronchitis is a disease caused by inflammation of the bronchi as a result of infectious agents or air pollutants. In this study our attention is to relate, the be- ginning of bronchitis attacks in the services of urgency of the Hospital of Aveiro with meteorological factors, and the risk group are studied. We used the medical records and the database of meteorological factors. The obtained analysis allows to conclude that some meteorological factors have correlation with the occurrences of the disease and to allow improving the work in the urgency services in the requested periods. The knowledge that will be extracted of this study can be used later in studies that inte- grate other important components for the characterisation of the environmental impact in the area. References: Talaia, M.A.R., Vieira da Cruz, A.A., Saraiva, M.A.C., Amaro, G.S., Oliveira, C.J. and Carvalho, C.F., 2000, The Influence of Meteorological Fac- tors on Pneumonia Emergencies in Aveiro, International Symposium on Human- Biometeorology, St. Petersburg (Pushkin), Russia, pp. 67-68. Talaia, M.A.R. and Vieira of Cruz, A.A., (2001), Meteorological Effects on the Resistance of the Body to Influenza - One Study in Aveiro Region, Proceedings 2nd Symposium of Meteorol- ogy and Geophysics of APMG and 3rd Meeting

  3. Chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    V K Vijayan

    2013-01-01

    Full Text Available The global prevalence of physiologically defined chronic obstructive pulmonary disease (COPD in adults aged >40 yr is approximately 9-10 per cent. Recently, the Indian Study on Epidemiology of Asthma, Respiratory Symptoms and Chronic Bronchitis in Adults had shown that the overall prevalence of chronic bronchitis in adults >35 yr is 3.49 per cent. The development of COPD is multifactorial and the risk factors of COPD include genetic and environmental factors. Pathological changes in COPD are observed in central airways, small airways and alveolar space. The proposed pathogenesis of COPD includes proteinase-antiproteinase hypothesis, immunological mechanisms, oxidant-antioxidant balance, systemic inflammation, apoptosis and ineffective repair. Airflow limitation in COPD is defined as a postbronchodilator FEV1 (forced expiratory volume in 1 sec to FVC (forced vital capacity ratio <0.70. COPD is characterized by an accelerated decline in FEV1. Co morbidities associated with COPD are cardiovascular disorders (coronary artery disease and chronic heart failure, hypertension, metabolic diseases (diabetes mellitus, metabolic syndrome and obesity, bone disease (osteoporosis and osteopenia, stroke, lung cancer, cachexia, skeletal muscle weakness, anaemia, depression and cognitive decline. The assessment of COPD is required to determine the severity of the disease, its impact on the health status and the risk of future events (e.g., exacerbations, hospital admissions or death and this is essential to guide therapy. COPD is treated with inhaled bronchodilators, inhaled corticosteroids, oral theophylline and oral phosphodiesterase-4 inhibitor. Non pharmacological treatment of COPD includes smoking cessation, pulmonary rehabilitation and nutritional support. Lung volume reduction surgery and lung transplantation are advised in selected severe patients. Global strategy for the diagnosis, management and prevention of Chronic Obstructive Pulmonary Disease

  4. Recombination in Avian Gamma-Coronavirus Infectious Bronchitis Virus

    Directory of Open Access Journals (Sweden)

    Mark W. Jackwood

    2011-09-01

    Full Text Available Recombination in the family Coronaviridae has been well documented and is thought to be a contributing factor in the emergence and evolution of different coronaviral genotypes as well as different species of coronavirus. However, there are limited data available on the frequency and extent of recombination in coronaviruses in nature and particularly for the avian gamma-coronaviruses where only recently the emergence of a turkey coronavirus has been attributed solely to recombination. In this study, the full-length genomes of eight avian gamma-coronavirus infectious bronchitis virus (IBV isolates were sequenced and along with other full-length IBV genomes available from GenBank were analyzed for recombination. Evidence of recombination was found in every sequence analyzed and was distributed throughout the entire genome. Areas that have the highest occurrence of recombination are located in regions of the genome that code for nonstructural proteins 2, 3 and 16, and the structural spike glycoprotein. The extent of the recombination observed, suggests that this may be one of the principal mechanisms for generating genetic and antigenic diversity within IBV. These data indicate that reticulate evolutionary change due to recombination in IBV, likely plays a major role in the origin and adaptation of the virus leading to new genetic types and strains of the virus.

  5. CT findings of plastic bronchitis in children after a Fontan operation

    Energy Technology Data Exchange (ETDEWEB)

    Goo, Hyun Woo [University of Ulsan College of Medicine, Department of Radiology and Research Institute of Radiology, Asan Medical Center, Seoul (Korea); Jhang, Won Kyoung; Kim, Young Hwee; Ko, Jae Kon; Park, In Sook [University of Ulsan College of Medicine, Department of Pediatric Cardiology, Asan Medical Center, Seoul (Korea); Park, Jeong-Jun; Yun, Tae-Jin; Seo, Dong-Man [University of Ulsan College of Medicine, Department of Pediatric Cardiac Surgery, Asan Medical Center, Seoul (Korea)

    2008-09-15

    Plastic bronchitis is a rare cause of acute obstructive respiratory failure in children. Life-threatening events are much more frequent in patients with repaired cyanotic congenital heart disease, and most frequent following a Fontan operation. Commonly, the diagnosis is not made until bronchial casts are expectorated. Detailed CT findings in plastic bronchitis have not been described. To describe the CT findings in plastic bronchitis in children after a Fontan operation. Three children with plastic bronchitis after a Fontan operation were evaluated by chest CT. Bronchial casts were spontaneously expectorated and/or extracted by bronchoscopy. Airway and lung abnormalities seen on CT were analyzed in the three children. CT demonstrated bronchial casts in the central airways with associated atelectasis and consolidation in all children. The affected airways were completely or partially obstructed by the bronchial casts without associated bronchiectasis. The airway and lung abnormalities rapidly improved after removal of the bronchial casts. CT can identify airway and lung abnormalities in children with plastic bronchitis after a Fontan operation. In addition, CT can be used to guide bronchoscopy and to monitor treatment responses, and thereby may improve clinical outcomes. (orig.)

  6. CT findings of plastic bronchitis in children after a Fontan operation

    International Nuclear Information System (INIS)

    Plastic bronchitis is a rare cause of acute obstructive respiratory failure in children. Life-threatening events are much more frequent in patients with repaired cyanotic congenital heart disease, and most frequent following a Fontan operation. Commonly, the diagnosis is not made until bronchial casts are expectorated. Detailed CT findings in plastic bronchitis have not been described. To describe the CT findings in plastic bronchitis in children after a Fontan operation. Three children with plastic bronchitis after a Fontan operation were evaluated by chest CT. Bronchial casts were spontaneously expectorated and/or extracted by bronchoscopy. Airway and lung abnormalities seen on CT were analyzed in the three children. CT demonstrated bronchial casts in the central airways with associated atelectasis and consolidation in all children. The affected airways were completely or partially obstructed by the bronchial casts without associated bronchiectasis. The airway and lung abnormalities rapidly improved after removal of the bronchial casts. CT can identify airway and lung abnormalities in children with plastic bronchitis after a Fontan operation. In addition, CT can be used to guide bronchoscopy and to monitor treatment responses, and thereby may improve clinical outcomes. (orig.)

  7. Development of inactivated-local isolate vaccine for infectious bronchitis

    Directory of Open Access Journals (Sweden)

    Darminto

    1999-06-01

    Full Text Available Infectious bronchitis (IB is an acute highly contagious viral respiratory disease of poultry caused by coronavirus. The disease causes high mortality in young chicks, reduce body weight gain in broilers and remarkable drop in egg production. IB can only be controlled by vaccination, but due to the antigenic variation among serotypes of IB viruses, the effective IB vaccine should be prepared from local isolates. The aim of this research is to develop inactivated IB vaccine derived from local IB isolates. Local isolates of IB viruses designated as I-37, I-269 and PTS-III were propagated respectively in specific pathogen free (SPF chicken eggs, the viruses then were inactivated by formaline at final concentration of 1:1,000. Subsequently, the inactivated viruses were mixed and emulsified in oil emulsion adjuvant with sorbitant mono-oleic as an emulsifier. The vaccine then was tested for its safety, potency and efficacy in broiler chickens. Birds inoculated twice with a two-week interval by inactivated vaccine did not show any adverse reaction, either systemic or local reaction. The inoculated birds developed antibody responses with high titre, while antibody of the control birds remain negative. In addition, efficacy test which was conducted in broilers demonstrated that birds vaccinated by live-commercial vaccine and boosted three weeks later by Balitvet inactivated vaccine showed high level of antibody production which provided high level of protection against challenged virus (76% against I-37, 92% against I-269 and 68% against PTS-III challenge viruses. From this study, it can be concluded that inactivated local IB vaccine is considered to be safe, potent and efficacious. The vaccine stimulates high titre of antibody responses, which provide high level of protection against challenged viruses.

  8. ANESTHETIC CONSIDERATION S IN CHRONIC OBSTRUCTIVE PULMON ARY DISEASE

    Directory of Open Access Journals (Sweden)

    Awati

    2015-03-01

    Full Text Available Chronic obstructive pulmonary disease (COPD is a spectrum of diseases that includes emphysema, chronic bronchitis, and small airway disease. It i s characterized by progressive increased resistance to breathing. Patients with marked obstructive pulmonary disease are at increased risk for both intraoperative and Postoperative pulmonary complications. These patients require thorough preoperative prepa ration, meticulous intraoperative management & postoperative care. This article describes anesthetic considerations in a patient with COPD.

  9. Can eosinophilic bronchitis be considered as an occupational disease? Medical certification aspects

    Directory of Open Access Journals (Sweden)

    Aneta Kleniewska

    2013-08-01

    Full Text Available Eosinophilic bronchitis (EB is a condition which can be associated with occupational exposure to low, as well as to high molecular weight allergens. The prevalence of occupational eosinophilic bronchitis is unknown and the data concerning its work-related etiology are available only from the case reports. However, there is a need to establish the principles, especially in the context of medical certification among workers occupationally exposed to allergens. This paper reviews current knowledge on the etiology, clinical features, and diagnostic procedures in the eosinophilic bronchitis. The importance of EB, especially in view of the problems emerging in the prophylactic care taken by occupational health services and the principles of medical certification when occupational etiology is suspected are also presented. Med Pr 2013;64(4:569–578

  10. High incidence of rickets in children with wheezy bronchitis in a developing country1

    OpenAIRE

    El-Radhi, A Sahib; Mansor, N; Majeed, M; Ibrahim, M

    1982-01-01

    The incidence of rickets in 100 Iraqi infants with wheezy bronchitis (24%) exceeded by two and a half times that found in age-matched controls (9%), and by ten times when only those with severe rickets were considered. The reason for this is not entirely clear, but could be related to the fact that the infants with wheezy bronchitis weighed more and therefore had grown faster than the control group. This itself could be related to the higher incidence of breastfeeding in the infants with whee...

  11. Radioimmunological allergy diagnostics in infants suffering from asthmatoid bronchitis, bronchial asthma, and hay fever

    International Nuclear Information System (INIS)

    The occurence of circulating specific antibodies against milk protein, hen protein, fish (cod), against cat, dog and horse epithelium as well as against 2 types of house dust was investigated with 11 children in the age of 1-6 years having asthmatoid bronchitis, 23 children aging from 2-15 years with bronchial asthma and 3 children aging from 6-13 years with hay fever, using the radioallergosorbens test (RAST). Children having asthmatoid bronchitis for the first time exhibited a smaller number and a lesser extent of positive radioallergosorben test results then children with bronchial asthma. The children with hay fever exhibited exclusively negative test results. (orig./LN)

  12. Association between Ambient Air Pollution and Outpatient Visits for Acute Bronchitis in a Chinese City

    Institute of Scientific and Technical Information of China (English)

    GUO Li Juan; ZHAO Ang; CHEN Ren Jie; KAN Hai Dong; KUANG Xing Ya

    2014-01-01

    Objective To investigate the short-term association between outdoor air pollution and outpatient visits for acute bronchitis, which is a rare subject of research in the mainland of China. Methods A time-series analysis was conducted to examine the association of outdoor air pollutants with hospital outpatient visits in Shanghai by using two-year daily data (2010-2011). Results Outdoor air pollution was found to be associated with an increased risk of outpatient visits for acute bronchitis in Shanghai. The effect estimates of air pollutants varied with the lag structures of the concentrations of the pollutants. For lag06, a 10μg/m3 increase in the concentrations of PM10, SO2, and NO2 corresponded to 0.94%(95%CI:0.83%, 1.05%), 11.12%(95%CI:10.76%, 11.48%), and 4.84%(95%CI: 4.49%, 5.18%) increases in hospital visits for acute bronchitis, respectively. These associations appeared to be stronger in females (P Conclusion Our analyses have provided the first evidence that the current air pollution level in China has an effect on acute bronchitis and that the rationale for further limiting air pollution levels in Shanghai should be strengthened.

  13. S2 expressed from recombinant virus confers broad protection against infectious bronchitis virus

    Science.gov (United States)

    We previously demonstrated that overexposing the IBV (infectious bronchitis virus) S2 to the chicken immune system by means of a vectored vaccine, followed by boost with whole virus, protects chickens against IBV showing dissimilar S1. We developed recombinant Newcastle disease virus (NDV) LaSota (...

  14. Histone deacetylase activity and recurrent bacterial bronchitis in severe eosinophilic asthma.

    Science.gov (United States)

    Zuccaro, L; Cox, A; Pray, C; Radford, K; Novakowski, K; Dorrington, M; Surette, M G; Bowdish, D; Nair, P

    2016-04-01

    An increase in P13 Kinase activity and an associated reduction in histone deacetylase activity may contribute to both relative steroid insensitivity in patients with severe eosinophilic asthma and impaired macrophage scavenger function and susceptibility to recurrent infective bronchitis that may, in turn, contribute to further steroid insensitivity. PMID:26715426

  15. Chronic bronchitis is an independently associated factor for more symptom and high-risk groups

    OpenAIRE

    Rhee, Chin Kook

    2016-01-01

    Joon Young Choi,1 Hyoung Kyu Yoon,2 Seoung Ju Park,3 Yong Bum Park,4 Kyeong-Cheol Shin,5 Ju Ock Na,6 Kwang Ha Yoo,7 Ki-Suck Jung,8 Young Kyoon Kim,1 Chin Kook Rhee1 1Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St Mary’s Hospital, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yeouido St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, 3Division of Pulmon...

  16. Early effects of intravenous terbutaline on cardiopulmonary function in chronic obstructive bronchitis and pulmonary hypertension.

    OpenAIRE

    Jones, R. M.; Stockley, R A; Bishop, J M

    1982-01-01

    Terbutaline sulphate (0.25 mg) was given intravenously to 10 recumbent patients with severe irreversible airflow obstruction and pulmonary hypertension who were undergoing right heart catheterisation. Alveolar ventilation index, cardiac index, and mean pulmonary artery pressure all rose significantly at 5 minutes and then fell by 35 minutes, although the first two remained higher than control levels. This was accompanied by a small but significant rise in arterial oxygen tension at 5 minutes....

  17. Quantified pathology of emphysema, pneumoconiosis, and chronic bronchitis in coal workers

    OpenAIRE

    Leigh, J; Outhred, K G; McKenzie, H. I.; Glick, M; Wiles, A N

    1983-01-01

    ABSTRACT From a continuous series of 886 postmortem examinations on coal mine workers in New South Wales, Australia, from 1949 to 1982 and their histories the following data were obtained: age at death (886 cases), percentage of emphysema in both lungs (Heard method) (870 cases), bronchial gland wall (G-W) ratio (Reid Index) (412 cases), chest radiograph within 10 years of death (792 cases), history of work at the coal face (844 cases), history of amount of tobacco smoked (606 cases), and FEV...

  18. Approaching chronic cough.

    Science.gov (United States)

    Poulose, Vijo; Tiew, Pei Yee; How, Choon How

    2016-02-01

    Chronic cough is one of the most common reasons for referral to a respiratory physician. Although fatal complications are rare, it may cause considerable distress in the patient's daily life. Western and local data shows that in patients with a normal chest radiograph, the most common causes are postnasal drip syndrome, postinfectious cough, gastro-oesophageal reflux disease and cough variant asthma. Less common causes are the use of angiotensin-converting enzyme inhibitors, smoker's cough and nonasthmatic eosinophilic bronchitis. A detailed history-taking and physical examination will provide a diagnosis in most patients, even at the primary care level. Some cases may need further investigations or specialist referral for diagnosis. PMID:26892615

  19. Cardiovascular Complications in Chronic Obstructive Pulmonary Disease with Reference to 2D Echocardiography Findings

    Directory of Open Access Journals (Sweden)

    Vikram B Vikhe

    2013-08-01

    Results: Emphysema and chronic bronchitis was present in 38% and 62% respectively. Echocardiographic evidence of cor-pulmonale and pulmonary hypertension was found in 70% of the patients. Conclusions: Echocardiography is more sensitive than electrocardiography in detecting PAH and right ventricular dysfunction in COPD. [Natl J Med Res 2013; 3(4.000: 385-388

  20. A comparative and descriptive study of asthma in chronic rhinosinusitis with nasal polyps

    DEFF Research Database (Denmark)

    Håkansson, Kåre; Thomsen, Simon Francis; Konge, Lars; Mortensen, Jann; Backer, Vibeke; von Buchwald, Christian

    2014-01-01

    : Compared with previous studies, we found a very high prevalence of asthma and, frequently, asthma was undiagnosed. Furthermore, CRSwNPs was associated with chronic bronchitis and, in those with asthma, lower airway obstruction. These results call for a closer collaboration between otorhinolaryngology and...

  1. A liquid phase blocking ELISA for the detection of antibodies against infectious bronchitis virus

    Directory of Open Access Journals (Sweden)

    Cardoso T.C.

    1999-01-01

    Full Text Available A liquid phase blocking ELISA (LPB-ELISA was developed for the detection and measurement of antibodies against infectious bronchitis virus (IBV. The purified and nonpurified virus used as antigen, the capture and detector antibodies, and the chicken hyperimmune sera were prepared and standardized for this purpose. A total of 156 sera from vaccinated and 100 from specific pathogen-free chickens with no recorded contact with the virus were tested. The respective serum titers obtained in the serum neutralization test (SNT were compared with those obtained in the LPB-ELISA. There was a high correlation (r2 = 0.8926 between the two tests. The LPB-ELISA represents a single test suitable for the rapid detection of antibodies against bronchitis virus in chicken sera, with good sensitivity (88%, specificity (100% and agreement (95.31%.

  2. Detection and identification of infectious bronchitis virus by RT-PCR in Iran.

    Science.gov (United States)

    Homayounimehr, Alireza; Pakbin, Ahmad; Momayyez, Reza; Fatemi, Seyyedeh Mahsa Rastegar

    2016-06-01

    Infectious bronchitis virus (IBV) causes severe diseases in poultry with significant economic consequences to the poultry industry in Iran. The aim of this study was the detection and identification of IBV by reverse transcription(RT)-PCR in Iran. Ten IB virus strains were detected by testing trachea, cecal tonsil, and kidney tissues collected from broiler and layer farms in Iran. In order to detect infectious bronchitis virus, an optimized RT-PCR was used. Primers targeting the conserved region of known IBV serotypes were used in the RT-PCR assay. Primers selectively detecting Massachusetts and 793/B type IB viruses were designed to amplify the S1 gene of the virus and used in the nested PCR test. Our findings indicate the circulation of at least three genotypes of IB viruses (Massachusetts, 793/B, and variant 2) among poultry flocks. PMID:27010714

  3. Effects of prednisone on eosinophilic bronchitis in asthma: a systematic review and meta-analysis*,**

    OpenAIRE

    Sakae, Thiago Mamôru; Maurici, Rosemeri; Trevisol, Daisson José; Pizzichini, Marcia Margaret Menezes; Pizzichini, Emílio

    2014-01-01

    OBJECTIVE: To evaluate the effect size of oral corticosteroid treatment on eosinophilic bronchitis in asthma, through systematic review and meta-analysis. METHODS: We systematically reviewed articles in the Medline, Cochrane Controlled Trials Register, EMBASE, and LILACS databases. We selected studies meeting the following criteria: comparing at least two groups or time points (prednisone vs. control, prednisone vs. another drug, or pre- vs. post-treatment with prednisone); and evaluating par...

  4. Effects of prednisone on eosinophilic bronchitis in asthma: a systematic review and meta-analysis,

    OpenAIRE

    Thiago Mamôru Sakae; Rosemeri Maurici; Daisson José Trevisol; Marcia Margaret Menezes Pizzichini; Emílio Pizzichini

    2014-01-01

    OBJECTIVE: To evaluate the effect size of oral corticosteroid treatment on eosinophilic bronchitis in asthma, through systematic review and meta-analysis. METHODS: We systematically reviewed articles in the Medline, Cochrane Controlled Trials Register, EMBASE, and LILACS databases. We selected studies meeting the following criteria: comparing at least two groups or time points (prednisone vs. control, prednisone vs. another drug, or pre- vs. post-treatment with prednisone); and evaluating par...

  5. Comparative evaluation of lung ventilation in patients with dust bronchitis and pneumoconiosis by roentgenopneumopolygraphy

    International Nuclear Information System (INIS)

    The results of roentgenopneumopolygraphy in 290 coal miners are analyzed. Localized diffuse ventilation disorders are detected, that are most pronounced in the upper and central lung regions. In all patients with dust bronchitis local and diffuse emphysematous ventilation disorders were detectable. In all patients with pneumoconiosis combined functional and morphologic changes were found. The use of X-ray function tests in coal miners facilitates an early detection of pathologic lung processes. (author)

  6. Evaluation of effectiveness of hydrolyzed dextran in treatment of dust-induced bronchitis

    Energy Technology Data Exchange (ETDEWEB)

    Slinchenko, N.Z.; Filipchenko, L.L.; Volkova, V.M.

    1986-05-01

    An experimental group and a control group identical in age, work experience, dust exposure and expression of disease were treated for dust-induced bronchitis. The control group received broncholytics, anti-inflammatory preparations and physiotherapy; the experimental group received same treatment plus 200 ml of rheopolyglucin, a 10% solution of dextran (water-soluble polysaccharide of glucose), twice a week for 2 to 3 weeks. In addition to general laboratory and clinical methods of investigation, cytologic analysis of sputum before and after treatment was carried out. Results of experiment are given in 3 tables showing: Dynamics of Allergic Signs after Treatment with Rheopolyglucin, Dynamics of Content of Eosinophils in Blood after Treatment, and Cytologic Characteristics of Mucus of Patients with Dust-Induced Bronchitis. Patients treated with rheopolyglucin improved more than control group in abatement of suppurative process in lungs, strengthening of specific cellular and humoral mechanisms of immune response at level of bronchopulmonary system, increased expulsion of mineral dust from lungs and significant reduction of allergic reaction. Results quantitated in tables prove advantages of adding rheopolyglucin to traditional therapy in treatment of dust-induced bronchitis. 19 refs.

  7. THE EFFECTS OF PRACTICING SWIMMING IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE. CASE STUDY

    OpenAIRE

    Petrescu S.; Ciolan G. A.; Păunescu M.

    2015-01-01

    Chronic obstructive pulmonary disease (COPD) is comprised primarily of two related diseases - chronic bronchitis and emphysema. Clinical research on the effects of swimming on the quality of the life of patients with various lung diseases showed that the use of water therapy programs have significant effects on the induction of pulmonary edema as well as on mild to moderate asthma. The case study presented in this study, aged 52, male, from urban area, smoker (30PA), with a weight of 96 kg an...

  8. Diagnosis and treatment of chronic cough in China: an insight into the status quo

    OpenAIRE

    Lai, Kefang; Luo, Wei; Zeng, Guangqiao; Zhong, Nanshan

    2012-01-01

    Chronic cough is a very common complaint in clinics throughout China. Clinical and basic science research on chronic cough started late, but in recent years the effort has yielded promising findings regarding the etiological diagnosis, treatment and pathogenesis. We found that inflammation in nonasthmatic eosinophilic bronchitis has some similarities to cough variant asthma but also a number of distinct differences. Recent evidence has also suggested a mechanistic link between airway neurogen...

  9. The hydrotherapy in the treatment of patients with Chronic Obstructive Pulmonary Disease

    OpenAIRE

    Fernanda Gadelha Severino; Maria Tereza Aguiar Pessoa Morano; Juliana Maria de Sousa Pinto

    2007-01-01

    The Chronic Obstructive Pulmonary Disease (COPD) is a serious, disabling disease,presenting the pulmonary function test with abnormalities in the expiratory flow. Underthis denomination, it comprises the chronic bronchitis and pulmonary emphysema. Thehydrotherapy involves the physical therapy with aquatic exercises and has being usedbecause it is a pleasant activity with positive results. The aim of this exploratory study was tocompare the performance of the patients with COPD treated with hy...

  10. Chronic pancreatitis

    Science.gov (United States)

    Chronic pancreatitis - chronic; Pancreatitis - chronic - discharge; Pancreatic insufficiency - chronic; Acute pancreatitis - chronic ... abuse over many years. Repeated episodes of acute pancreatitis can lead to chronic pancreatitis. Genetics may be ...

  11. Effective use of corticosteroids in treatment of plastic bronchitis with hemoptysis in Chinese adults

    Institute of Scientific and Technical Information of China (English)

    Gang WANG; You-juan WANG; Feng-ming LUO; Lei WANG; Li-li JIANG; Lin WANG; Bing MAO

    2006-01-01

    Aim: To investigate whether corticosteroids are effective in the treatment of plastic bronchitis with hemoptysis. Methods: A retrospective, clinical study was undertaken. Thirty two patients with only first episodes of plastic bronchitis with hemoptysis were divided into a steroid group (n=18) treated with glucocorticoids, and a non-steroid group (n=14). The supportive therapy was uniformly applied to both groups, except for glucocorticoids. Variables such as temperature and white blood cell counts were determined. Furthermore, the volume of hemoptysis and bronchial casts were evaluated in detail daily. Results: There was no difference in the demographic data and variables at baseline between both groups (all P>0.05).On days 5,6,7 and 8, the volume of hemoptysis was significantly decreased in the steroid group compared with the non-steroid group (43±15 mL vs 117±33 mL on d 5,29±12mL vs 97±23mL on d 6,18±10mL vs 80±20mL on d 7,and 13±8mL vs 66±14 mL on d 8; all P<0.05), and on d 10 after fibreoptic bronchoscopy, the cases with bronchial casts was reduced evidently in the steroid group in comparison with the non-steroid group (OR=5.69,95% CI=1.76-43.6; P=0.005). There was no significance in mechanical ventilation and mortality between both groups. Conclusion: Despite some limitations of this study, it has been demonstrated that, on the basis of common supportive therapy, corticosteroids would be effective and safe for the treatment of plastic bronchitis with hemoptysis.

  12. THE USAGE OF HALOAEROSOLOTHERAPY IN THE REHABILITATIONAL TREATMENT OF CHILDREN WITH RECCURENT BRONCHITIS

    Directory of Open Access Journals (Sweden)

    LEMKO Ivan

    2015-05-01

    Full Text Available Aim. Comparative evaluation of the effectiveness of various therapeutic complexes on the basis of haloaerosoltherapy in the rehabilitational treatment of children with recurrent bronchitis on the ground of clinical and functional data and further development of recommendations for differentiated treatment. Objectives. Children (at the age of 6-10 years with recurrent bronchitis, who received treatment in conditions of artificial rock salt aerosol medium (haloaerosoltherapy. Material and Methods. 35 children with recurrent bronchitis (RB were examined. All children’s clinical data were monitored; respiratory function was evaluated using spirography. Forced inspiratory vital capacity (FIVC, forced expiratory volume for the 1-st second (FEV1, peak expiratory flow (PEF, forced expiratory flow at the point of 25% from FIVC(FEF25, forced expiratory flow at the point of 50% from FIVC (FEF50, and forced expiratory flow at the point of 75% from FIVC (FEF75 were defined. The patients were treated with the help of two therapeutic complexes (TC. 12 children were treated by the first TC which included haloaerosoltherapy (14 procedures, in well-equipped room with the initial concentration of rock salt aerosol 40 mg/m3 and the predominance of fine powder fraction (<80%. The first procedure lasted 10 minutes, the second – 20 minutes, the third and the following ones – 30 minutes. The concentration and dispersity of haloaerosol were measured with the help of special laser optical system. 23 children underwent second TC, which included 12 procedures of singlet oxygen therapy in the form of foam additionally to the haloaerosoltherapy sessions. Results. At the beginning of the treatment children had no signs of the acute phase of the disease. Though there were some symptoms which testify that the inflammatory process and functional recovery are not finished yet after the acute phase of the recurrent bronchitis. The clinical picture was confirmed by the major

  13. Measurement of Antibodies to Infectious Bronchitis Virus in Indigenous Chicken Flocks Around Maharlou Lake in Iran

    Directory of Open Access Journals (Sweden)

    M.M. Hadipour

    2011-06-01

    Full Text Available To evaluate the seroprevalence of Infectious Bronchitis Virus (IBV in indigenous chicken flocks, serum samples from 200 mature indigenous chickens in villages around Maharlou Lake in Southwest of Iran were tested for IBV antibodies using commercial IBV Enzyme-Linked Immunosorbent Assay (ELISA. The studied indigenous chickens had not been previously vaccinated and showed no clinical signs of disease. The overall ELISA titer and seroprevalence of IBV antibodies revealed in this study were 1427 and 68%, respectively. The results indicate a relatively high prevalence of IBV in indigenous chicken flocks in Southwest of Iran and necessitate the regular vaccination programme against IB in native flocks.

  14. Detection of infectious bronchitis virus strains similar to Japan in Taiwan.

    Science.gov (United States)

    Tsai, Cheng-Ta; Tsai, Hsin-Fu; Wang, Ching-Ho

    2016-06-01

    A total of 1,320 tracheal samples from 66 broiler flocks sent to slaughterhouses and 42 tracheal samples from 42 flocks of local chickens in the field were collected for infectious bronchitis virus (IBV) gene detection by reverse transcription polymerase chain reaction using nucleocapsid-specific primers and spike-specific primers. Prevalence in broiler flocks was 39.4% (26/66) and in local chicken flocks was 11.9% (5/42). Several IBVs similar to Japan were detected in Taiwan. One-direction neutralization revealed that the reference antisera did not offer protection against the IBVs similar to those from Japan. PMID:26822119

  15. A STUDY OF CLINICAL, RADIOLOGICAL, PULMONARY FUNCTIONS IN PATIENTS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

    Directory of Open Access Journals (Sweden)

    Vishnukanth

    2014-06-01

    Full Text Available Respiratory diseases impose a tremendous health burden on society. As countries industrialize, rising pollution and changes in lifestyle have contributed to increased levels of respiratory disease. Chronic obstructive pulmonary disease (COPD refers to a group of disorders characterized by chronic airflow obstruction/limitation. The airway obstruction is persistent and largely irreversible. WHO defines COPD as encompassing two groups of lung diseases, chronic bronchitis and emphysema. The present universally accepted guidelines no longer divide COPD into chronic bronchitis or emphysema as there is not much difference with regard to treatment protocols. AIM: The present study is being undertaken to evaluate the clinical, radiological and pulmonary functions in patients of COPD. An attempt also has been made to classify patients of COPD into chronic bronchitis and emphysema. A total of 153 patients were screened and inclusion and exclusion criteria applied. Forty patients were evaluated clinically, radiologically and pulmonary functions including diffusion studies were done. They were phenotypically divided into emphysema predominant and chronic bronchitis predominant. Breathlessness as assessed by MMRC grade and pulmonary functions were equal in both the groups. There was no radiological and phenotypical correlation. CONCLUSION: There is no significant difference in the severity of airflow obstruction as measured by FEV1 between the two phenotypes of COPD (Fisher’s exact test, P>0.05. There is a significant overlapping of symptoms, radiological findings and pulmonary functions among the phenotypes of COPD. Hence it can be reasonably concluded that it is difficult to make a diagnosis of COPD phenotypes based on clinical, radiological, spirometry and DLCo parameters

  16. Adjuvant effects of mannose-binding lectin ligands on the immune response to infectious bronchitis vaccine in chickens with high or low serum mannose-binding lectin concentrations

    DEFF Research Database (Denmark)

    Kjærup, Rikke Munkholm; Dalgaard, Tina Sørensen; Norup, Liselotte Rothmann; Bergman, Ingrid-Maria; Sørensen, Poul; Juul-Madsen, Helle Risdahl

    2014-01-01

    MBL participates in the protection of hosts against virus infections. Infectious bronchitis (IB) is a highly contagious disease of economic importance in the poultry industry caused by the coronavirus infectious bronchitis virus (IBV). MBL has earlier been described to play a potential role in the...

  17. The hydrotherapy in the treatment of patients with Chronic Obstructive Pulmonary Disease - doi:10.5020/18061230.2007.p221

    OpenAIRE

    Fernanda Gadelha Severino; Maria Tereza Aguiar Pessoa Morano; Juliana Maria de Sousa Pinto

    2012-01-01

    The Chronic Obstructive Pulmonary Disease (COPD) is a serious, disabling disease, presenting the pulmonary function test with abnormalities in the expiratory flow. Under this denomination, it comprises the chronic bronchitis and pulmonary emphysema. The hydrotherapy involves the physical therapy with aquatic exercises and has being used because it is a pleasant activity with positive results. The aim of this exploratory study was to compare the performance of the patients with COPD trea...

  18. Studies on Molecular Variant Mechanism of Infectious Bronchitis Viruses of Beijing Area

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Using reverse transcription-nested Polymerase Chain Reaction(RT-nested PCR), the S1 gene hypervariable regions of Avian Infectious Bronchitis Viruses(IBV) strains BJ1, BJ2, BJ3, isolated from Beijing areas, were amplified successfully. The region consists of 1054 bp of 5'-end of S1 gene which were regarded as the most variable region among IBV strains. Sequences of the S1 gene were determined from recombinant plasmids by using the dideoxy sequencing technique in two directions. Comparing three isolates with standard strains M41, Beaudette, vaccine strain H120 and one isolated strain D41 from Guangdong province, it was shown they were more homology in nucleotide sequence and deduced amino acid sequence with M41 than Beaudette and H120. However, secondary structure of their encoding proteins are more similar with H120 than M41 and Beaudette strains. All of these indicate there are complex relationship among difference of nucleotide sequence, changes of virus determinants and serotypes in Infectious Bronchitis Virus.

  19. The proteome of the infectious bronchitis virus Beau-R virion.

    Science.gov (United States)

    Dent, Stuart D; Xia, Dong; Wastling, Jonathan M; Neuman, Benjamin W; Britton, Paul; Maier, Helena J

    2015-12-01

    Infectious bronchitis is a highly contagious respiratory disease of poultry caused by the coronavirus infectious bronchitis virus (IBV). It was thought that coronavirus virions were composed of three major viral structural proteins until investigations of other coronaviruses showed that the virions also include viral non-structural and genus-specific accessory proteins as well as host-cell proteins. To study the proteome of IBV virions, virus was grown in embryonated chicken eggs, purified by sucrose-gradient ultracentrifugation and analysed by mass spectrometry. Analysis of three preparations of purified IBV yielded the three expected structural proteins plus 35 additional virion-associated host proteins. The virion-associated host proteins had a diverse range of functional attributions, being involved in cytoskeleton formation, RNA binding and protein folding pathways. Some of these proteins were unique to this study, while others were found to be orthologous to proteins identified in severe acute respiratory syndrome coronavirus virions and also virions from a number of other RNA and DNA viruses. PMID:27257648

  20. Immune Responses to Virulent and Vaccine Strains of Infectious Bronchitis Viruses in Chickens.

    Science.gov (United States)

    Chhabra, Rajesh; Chantrey, Julian; Ganapathy, Kannan

    2015-11-01

    Infectious bronchitis (IB) is an acute and highly contagious chicken viral disease, causing severe economic losses to poultry producers worldwide. In the last few decades, infectious bronchitis virus (IBV) has been extensively studied, but knowledge of immune responses to virulent or vaccine strains of IBVs remains limited. This review focuses on fundamental aspects of immune responses against IBV, including the role of pattern recognition receptors (PRRs) in identification of conserved viral structures and the role of different components of innate immunity (e.g., heterophils, macrophages, dendritic cells, acute phase protein, and cytokines). Studies on adaptive immune activation and the role of humoral and cellular immunity in IBV clearance are also reviewed. Multiple interlinking immune responses are essential for protection against virulent IBVs, including passive, innate, adaptive, and effector T cells active at mucosal surfaces. Although the development of approaches for chicken transcriptome and proteome analyses have greatly helped the understanding of the underlying genetic mechanisms for immunity, there are still major knowledge gaps, such as the role of mucosal and cellular responses to IBVs. In view of recent reports of emergent IBV variants in many countries, there is renewed interest in a more complete understanding of poultry immune responses to both virulent and vaccine strains of IBVs. This will be critical for developing new vaccine or vaccination strategies and other intervention programs. PMID:26301315

  1. Adaptation of infectious bronchitis virus in primary cells of the chick embryo chorioallantoic membrane

    Directory of Open Access Journals (Sweden)

    M. H. Mohammed

    2013-06-01

    Full Text Available The susceptibility of the primary chick embryo chorioallontoic membrane cells to infectious bronchitis virus was evaluated after twenty consecutive passages in chick embryo chorioallontoic membrane cells. Virus replication was monitored by cytopathic observation, indirect immunoperoxidase, and reverse transcription polymerase chain reaction (RT-PCR. At 72 hours post-infection (p.i. in third passage, the cytopathic effect was characterized by rounding up of cells, monolayer detachment, intracytoplasmic brownish colouration was readily observed by immunoperoxidase from 24 hours p.i in third passage, and at all times the extracted viral RNA from IBV-infected monolayers was demonstrated by RT-PCR. Tissue culture ineffective dose50 (TCID50 was used to measure virus titration performed on primary chick embryo chorioallontoic membrane cells and the titre in twenty passage was 108.6 TCID50/ml. The results obtained in this study suggested that the primary chick embryo chorioallontoic membrane cells can be used for adaptation infectious bronchitis virus (IBV and may be considered a step forward for the use of these cells in the future for IBV vaccine production

  2. Radiation bronchitis and stenosis secondary to high dose rate endobronchial irradiation

    International Nuclear Information System (INIS)

    The purpose of the study was to describe a new clinical entity observed in follow-up bronchoscopies in patients who were treated with high dose rate and medium dose rate remote afterloading brachytherapy of the tracheobronchial tree. Patients were treated by protocol with medium dose rate, 47 patients receiving 1000 cGy at a 5 mm depth times three fractions, high dose rate 144 patients receiving 1000 cGy at a 10 mm depth for three fractions and high dose rate 151 patients receiving cGy at a 10 mm depth for three fractions followed by bronchoscopy. Incidence of this entity was 9% for the first group, 12% for the second, and 13% for the third group. Reactions were grade 1 consisting of mild inflammatory response with a partial whitish circumferential membrane in an asymptomatic patient; grade 2, thicker complete white circumferential membrane with cough and/or obstructive problems requiring intervention; grade 3, severe inflammatory response with marked membranous exudate and mild fibrotic reaction; and grade 4 a predominant fibrotic reaction with progressive stenosis. Variables associated with a slightly increased incidence of radiation bronchitis and stenosis included: large cell carcinoma histology, curative intent, prior laser photoresection, and/or concurrent external radiation. Survival was the strongest predictor of the reaction. Radiation bronchitis and stenosis is a new clinical entity that must be identified in bronchial brachytherapy patients and treated appropriately. 23 refs., 3 figs., 7 tabs

  3. Purification, crystallization and preliminary crystallographic analysis of avian infectious bronchitis virus nsp3 ADRP domain

    International Nuclear Information System (INIS)

    The crystal of the nsp3 ADRP domain of avian infectious bronchitis virus (IBV) has been obtained and subjected to further crystallograghic studies. Avian infectious bronchitis virus (IBV) encodes 15 nonstructural proteins (nsps) which play crucial roles in RNA transcription and genome replication. One of them, nsp3, contains an ADRP (adenosine diphosphate-ribose-1′-phosphatase) domain which was revealed in recent studies to have ADP-ribose-1′-monophosphatase (Appr-1′-pase) activity. Appr-1′-pase catalyzes the conversion of ADP-ribose-1′-monophosphate (Appr-1′-p) to ADP-ribose in the tRNA-splicing pathway. The gene segment encoding the IBV nsp3 ADRP domain has been cloned and expressed in Escherichia coli. The protein has been crystallized and the crystals diffracted to 1.8 Å resolution. They belonged to space group P1, with unit-cell parameters a = 41.1, b = 43.2, c = 48.9 Å, α = 78.0, β = 80.0, γ = 73.6°. Each asymmetric unit contains two molecules

  4. Crystallization and preliminary X-ray diffraction studies of infectious bronchitis virus nonstructural protein 9

    International Nuclear Information System (INIS)

    The gene segment encoding avian infectious bronchitis virus nonstructural protein 9 has been cloned and expressed in Escherichia coli. The protein has been crystallized and the crystals diffracted X-rays to 2.44 Å resolution. Avian infectious bronchitis virus (IBV), which causes respiratory disease in infected birds, belongs to coronavirus group 3. IBV encodes 15 nonstructural proteins (nsp2–nsp16) which play crucial roles in RNA transcription and genome replication. Nonstructural protein 9 (nsp9) has been identified as a protein that is essential to viral replication because of its single-stranded RNA-binding ability. The gene segment encoding IBV nsp9 has been cloned and expressed in Escherichia coli. The protein has been crystallized and the crystals diffracted X-rays to 2.44 Å resolution. They belonged to the cubic space group I432, with unit-cell parameters a = b = c = 123.4 Å, α = β = γ = 90°. The asymmetric unit appeared to contain one molecule, with a solvent content of 62% (VM = 3.26 Å3 Da−1)

  5. Chronic Diarrhea

    Science.gov (United States)

    ... infections that cause chronic diarrhea be prevented? Chronic Diarrhea What is chronic diarrhea? Diarrhea that lasts for more than 2-4 ... represent a life-threatening illness. What causes chronic diarrhea? Chronic diarrhea has many different causes; these causes ...

  6. Mucus Hyperconcentration as a Unifying Aspect of the Chronic Bronchitic Phenotype.

    Science.gov (United States)

    Button, Brian; Anderson, Wayne H; Boucher, Richard C

    2016-04-01

    Abnormalities in mucus production and qualitative properties such as mucus hydration are central to the pathophysiology of airway disease including cystic fibrosis, asthma, and chronic bronchitis. In vitro air-liquid interface epithelial cell cultures demonstrate direct relationships between mucociliary transport, periciliary liquid (PCL) height, and mucus concentration (expressed as percent solids or partial osmotic pressure). In health, the osmotic modulus/pressure of the PCL exceeds that of the mucus layer, resulting in efficient, low-friction movement of mucus. In disease, through multiple mechanisms, the osmotic pressure of the mucus begins to exceed basal PCL values, resulting in compression of the cilia and slowing of mucus transport. The in vivo data in both cystic fibrosis and chronic bronchitis parallel in vitro data demonstrating that when mucus osmotic pressure is increased, mucociliary clearance is decreased. In chronic bronchitis, there is a direct correlation between FEV1 and percent solids of mucus, demonstrating a strong relationship between disease progression and mucus abnormalities. Animal models, based mechanistically on raised sodium absorption (and therefore water absorption) from airway surfaces, mimic the pathophysiology of chronic obstructive pulmonary disease. Collectively, these data suggest the importance of mucus concentration in the pathogenesis of airway disease. It is important to understand the precise mechanisms that result in mucus hyperconcentration, for example, mucin overproduction versus abnormal regulation of ion/water transport, which may be unique to and characteristic of each disease phenotype. The measurement of mucus concentration may be a simple method to diagnose chronic bronchitis, monitor its progression, and serve as a biomarker for development of new therapies. PMID:27115951

  7. Treatment of 301 Infantile Acute Bronchitis Patients withQingre Lifei (清热利肺) Oral Liquid

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    From December 1995 to May 1996, 4 hospitals in Beijing, Guangzhou and Chengdu had 301 patients with infantile acute bronchitis (IAB) treated with Qingre Lifei (清热利肺, QRLF) oral liquid and the results compared with that of similar cases treated with Shema (射麻, SM) oral liquid. Following is the report.

  8. Comparison of the results of X-ray, endoscopic and radionuclide investigations in patients with deforming bronchitis

    International Nuclear Information System (INIS)

    Comprehensive investigation including panoramic chest X-ray, tomography, bronchofibroscopy with biopsy, bronchography, and comprehensive radionuclide investigation, were used in 233 patients with deforming bronchitis. All the patients were divided into 3 groups. Endoscopic findings corresponded to the results of comprehensive radionuclide investigation in all the groups

  9. Association of residential dampness and mold with respiratory tract infections and bronchitis: a meta-analysis

    Energy Technology Data Exchange (ETDEWEB)

    Fisk, William J.; Eliseeva, Ekaterina A.; Mendell, Mark J.

    2010-11-15

    Dampness and mold have been shown in qualitative reviews to be associated with a variety of adverse respiratory health effects, including respiratory tract infections. Several published meta-analyses have provided quantitative summaries for some of these associations, but not for respiratory infections. Demonstrating a causal relationship between dampness-related agents, which are preventable exposures, and respiratory tract infections would suggest important new public health strategies. We report the results of quantitative meta-analyses of published studies that examined the association of dampness or mold in homes with respiratory infections and bronchitis. For primary studies meeting eligibility criteria, we transformed reported odds ratios (ORs) and confidence intervals (CIs) to the log scale. Both fixed and random effects models were applied to the log ORs and their variances. Most studies contained multiple estimated ORs. Models accounted for the correlation between multiple results within the studies analyzed. One set of analyses was performed with all eligible studies, and another set restricted to studies that controlled for age, gender, smoking, and socioeconomic status. Subgroups of studies were assessed to explore heterogeneity. Funnel plots were used to assess publication bias. The resulting summary estimates of ORs from random effects models based on all studies ranged from 1.38 to 1.50, with 95% CIs excluding the null in all cases. Use of different analysis models and restricting analyses based on control of multiple confounding variables changed findings only slightly. ORs (95% CIs) from random effects models using studies adjusting for major confounding variables were, for bronchitis, 1.45 (1.32-1.59); for respiratory infections, 1.44 (1.31-1.59); for respiratory infections excluding nonspecific upper respiratory infections, 1.50 (1.32-1.70), and for respiratory infections in children or infants, 1.48 (1.33-1.65). Little effect of publication

  10. Natural histories of chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Rennard, Stephen I; Vestbo, Jørgen

    2008-01-01

    Concepts relating to the natural history of chronic obstructive pulmonary disease (COPD) arise most importantly from the classic study of Fletcher and colleagues (The Natural History of Chronic Bronchitis and Emphysema, Oxford University Press, New York, 1976). This study, which evaluated working...... English men over 8 years, was used to construct a proposed life-long natural history. Although this is a classic study that has greatly advanced understanding of COPD, it has a number of limitations. Its duration is relatively short compared with the duration of COPD, so it is more cross-sectional than...... longitudinal. It was unable to distinguish among varied "natural histories." It assessed primarily the FEV(1), and the natural history of other features of COPD is largely undescribed. With advances in understanding the clinical features of COPD and with the development of evaluating new tools to assess...

  11. Detection of variant infectious bronchitis viruses in Sri Lanka (2012-2015).

    Science.gov (United States)

    Ball, Christopher; Forrester, Anne; Ganapathy, Kannan

    2016-06-01

    Poultry production is an important sector of agriculture in Sri Lanka; however, there is a lack of information regarding circulation of infectious bronchitis virus (IBV). RNA was extracted from chicken tissues, subjected to IBV S1 RT-PCR, and sequenced. Overall, 19 out of 34 (55.88 %) samples were IBV positive and contained the genotype 793B (n = 13; 68.42 %), D274 (n = 4; 21.05 %) or Massachusetts (n = 2; 10.53 %). All three genotypes contained at least one strain with less than 99 % nucleotide sequence identity to the corresponding vaccine strains. This report identified co-circulation of IBV strains 793B, Massachusetts and D274, in Sri Lanka that are divergent from the respective vaccine strains. PMID:27020570

  12. The cytoplasmic tails of infectious bronchitis virus E and M proteins mediate their interaction

    International Nuclear Information System (INIS)

    Virus-like particle (VLP) formation by the coronavirus E and M proteins suggests that interactions between these proteins play a critical role in coronavirus assembly. We studied interactions between the infectious bronchitis virus (IBV) E and M proteins using in vivo crosslinking and VLP assembly assays. We show that IBV E and M can be crosslinked to each other in IBV-infected and transfected cells, indicating that they interact. The cytoplasmic tails of both proteins are important for this interaction. We also examined the ability of the mutant and chimeric E and M proteins to form VLPs. IBV M proteins that are missing portions of their cytoplasmic tails or transmembrane regions were not able to support VLP formation, regardless of their ability to be crosslinked to IBV E. Interactions between the E and M proteins and the membrane bilayer are likely to play an important role in VLP formation and virus budding

  13. Survey on circulation of infectious bronchitis virus strains in Northern Italy

    Directory of Open Access Journals (Sweden)

    Cristian De Battisti

    2010-01-01

    Full Text Available Infectious Bronchitis (IB still causes significant health problems in the poultry industry with high economic impact. The presence of several serotypes of IB and the emergence of novel ones must be monitored in order to take appropriate action and to adapt the vaccination programmes to the prevalent serotypes. In order to establish which serotypes are circulating in densely populated poultry area (DPPA of Northern Italy, a surveillance programme has been undertaken during 2004 and 2005. The results of this surveillance programme show the active circulation of 793-B, IT-02, the introduction of a novel strain, known as QXIBV, originally identified in China and the re-emergence of previously circulating serotype as B1648.

  14. Effects of prednisone on eosinophilic bronchitis in asthma: a systematic review and meta-analysis,

    Directory of Open Access Journals (Sweden)

    Thiago Mamôru Sakae

    2014-10-01

    Full Text Available OBJECTIVE: To evaluate the effect size of oral corticosteroid treatment on eosinophilic bronchitis in asthma, through systematic review and meta-analysis. METHODS: We systematically reviewed articles in the Medline, Cochrane Controlled Trials Register, EMBASE, and LILACS databases. We selected studies meeting the following criteria: comparing at least two groups or time points (prednisone vs. control, prednisone vs. another drug, or pre- vs. post-treatment with prednisone; and evaluating parameters before and after prednisone use, including values for sputum eosinophils, sputum eosinophil cationic protein (ECP, and sputum IL-5-with or without values for post-bronchodilator FEV1-with corresponding 95% CIs or with sufficient data for calculation. The independent variables were the use, dose, and duration of prednisone treatment. The outcomes evaluated were sputum eosinophils, IL-5, and ECP, as well as post-bronchodilator FEV1. RESULTS: The pooled analysis of the pre- vs. post-treatment data revealed a significant mean reduction in sputum eosinophils (↓8.18%; 95% CI: 7.69-8.67; p < 0.001, sputum IL-5 (↓83.64 pg/mL; 95% CI: 52.45-114.83; p < 0.001, and sputum ECP (↓267.60 µg/L; 95% CI: 244.57-290.63; p < 0.0001, as well as a significant mean increase in post-bronchodilator FEV1 (↑8.09%; 95% CI: 5.35-10.83; p < 0.001. CONCLUSIONS: In patients with moderate-to-severe eosinophilic bronchitis, treatment with prednisone caused a significant reduction in sputum eosinophil counts, as well as in the sputum levels of IL-5 and ECP. This reduction in the inflammatory response was accompanied by a significant increase in post-bronchodilator FEV1.

  15. Genome sequencing and characterization analysis of a Beijing isolate of chicken corona virus infectious bronchitis virus

    Institute of Scientific and Technical Information of China (English)

    JIN Weiwu; YU Jialin; LI Ning; GONG Yuanshi; SUN Qixin; CHEN Zhangliang; CHEN Chen; ZHANG Ying; ZHAO Yiqiang; FENG Jidong; CHEN Fuyong; WU Qingming; YANG Hanchun; WANG Ming

    2004-01-01

    Avian infectious bronchitis virus (AIBV) is lassified as a member of the genus coronavirus in the family coronaviridae. The enveloped virus has a positive-sense, single-stranded RNA genome of approximately 28 kilo-bases,which has a 5′ cap structure and 3′ polyadenylation tract.The complete genome sequence of infectious bronchitis virus (IBV), Beijing isolate, was determined by cloning sequencing and primer walking. The whole genome is 27733 nucleotides in length, has ten open reading frames: 5′-orfla-orflab-s-3a-3b-e-m- 6a-6b-n-3′. Alignments of the genome sequence of IBV Beijing isolate with those of two AIBV strains and one SARS coronavirus were performed respectively. The genome sequence of IBV Beijing isolate compared with that of the IBV strain LX4 (uncompleted, 19440 bp in size) was 91.2%similarity. However, the full-length genome sequence of IBV Beijing isolate was 85.2% identity to that of IBV Strain Beaudette, and was only 50.8% homology to that of SARS coronavirus. The results showed that the genome of IBV has remarkable variation. And IBV Beijing isolate is not closely related to SARS coronavirus. Phylogenetic analyses based on the whole genome sequence, S protein, M protein and N protein, also showed that AIBV Beijing isolate is lone virus in group Ⅲ and is distant from SARS coronavirus. In conclusion, this study will contribute to the studies of diagnosis and diseases control on IBV in China.

  16. Feline aminopeptidase N is not a functional receptor for avian infectious bronchitis virus

    Directory of Open Access Journals (Sweden)

    Harbison Carole E

    2007-02-01

    Full Text Available Abstract Background Coronaviruses are an important cause of infectious diseases in humans, including severe acute respiratory syndrome (SARS, and have the continued potential for emergence from animal species. A major factor in the host range of a coronavirus is its receptor utilization on host cells. In many cases, coronavirus-receptor interactions are well understood. However, a notable exception is the receptor utilization by group 3 coronaviruses, including avian infectious bronchitis virus (IBV. Feline aminopeptidase N (fAPN serves as a functional receptor for most group 1 coronaviruses including feline infectious peritonitis virus (FIPV, canine coronavirus, transmissible gastroenteritis virus (TGEV, and human coronavirus 229E (HCoV-229E. A recent report has also suggested a role for fAPN during IBV entry (Miguel B, Pharr GT, Wang C: The role of feline aminopeptidase N as a receptor for infectious bronchitis virus. Brief review. Arch Virol 2002, 147:2047–2056. Results Here we show that, whereas both transient transfection and constitutive expression of fAPN on BHK-21 cells can rescue FIPV and TGEV infection in non-permissive BHK cells, fAPN expression does not rescue infection by the prototype IBV strain Mass41. To account for the previous suggestion that fAPN could serve as an IBV receptor, we show that feline cells can be infected with the prototype strain of IBV (Mass 41, but with low susceptibility compared to primary chick kidney cells. We also show that BHK-21 cells are slightly susceptible to certain IBV strains, including Ark99, Ark_DPI, CA99, and Iowa97 ( Conclusion We conclude that fAPN is not a functional receptor for IBV, the identity of which is currently under investigation.

  17. Serotype variation among infectious bronchitis viral isolates taken from several areas of Java

    Directory of Open Access Journals (Sweden)

    Risa Indriani

    2000-12-01

    Full Text Available Infectious bronchitis (IB is an acute highly contagious viral respiratory disease of poultry caused by virus belongs to the family of Coronaviridae. The virus consist of many serotypes with low level of cross-protectivity among serotypes. Field data showed that the outbreaks of IB were frequently reported in chicken flocks, although vaccinations against the disease have been practiced. Hence, the study on serotype relationship among isolates of the viruses is essentially required. The aim of this study was to isolate and characterize IB viruses from chicken flocks in some areas of Java. Isolation of the virus was carried out in nine-day old embrionated chicken eggs and identified by means of agar gel precipitation (AGP tests against standard antisera to IB virus. The serotypes of the IB viral isolates were determined by cross-neutralization tests in nine day old embryonated chicken eggs using r value derived from homologous and heterologous serum titres as criteria. This study obtained 12 IB viral isolates which were identified on the basis of the ability to cause lesions in chicken embryos and positive to agar gel presipitation test against standard positive antiserum to the virus. Based on the cross-neutralization tests in embryonated chicken eggs, isolate I.9 was formed to have relationship closed to Mass-41 serotype, while I.2, I. 3, and I.7 isolates were closely to the serotype of Con-46. Virus isolates (I.5, I.14, I.24, and I.25 were decided to have no serotype relationships to either Mass-41 or Con-46 serotype. Since the I.5, I.14, I.24 and I.25 isolates were not neutralized by antisera against the previous identified local infectious bronchitis viral isolates, and that were considered to be distinct serotype to the previously identified local IB viral isolates.

  18. Interpretation of bronchodilator response in patients with obstructive airways disease. The Dutch Chronic Non-Specific Lung Disease (CNSLD) Study Group.

    OpenAIRE

    Brand, P L; Quanjer, P. H.; Postma, D. S.; Kerstjens, H.A.; Koëter, G. H.; Dekhuijzen, P. N.; Sluiter, H J

    1992-01-01

    BACKGROUND: There is no agreement on how a bronchodilator response should be expressed. Ideally, the index used should be able to distinguish asthma from chronic obstructive lung disease and be independent of initial FEV1. METHODS: Two hundred and seventy four adults (aged 18-60 years) outpatients with obstructive airways disease were studied. Patients were divided into syndrome groups on the basis of a standardised history: asthma (n = 99), asthmatic bronchitis (n = 88), and chronic obstruct...

  19. Treatment of Cough and Dyspnea due to Acute Bronchitis by Plaster for Cough and Dyspnea-A Report of 735 Cases

    Institute of Scientific and Technical Information of China (English)

    陈振甫; 周文秀; 高举先; 孙江桥

    2002-01-01

    @@ In the light of the theory of treating the internal disease externally, an externally used plaster for treating cough and dyspnea due to acute bronchitis (Ke Chuan Yi Tie Kang 咳喘一贴康) was successfully applied to 735 cases of acute bronchitis (the treatment group), with the other 423 cases treated with routine western drugs as controls. The results showed that the cure rate in the treatment group was significantly higher than that in the control group (P<0.01); and that in the treatment group, the cure rate for the wind-cold type of acute bronchitis was significantly higher than that for the wind-heat type of acute bronchitis (P<0.01).

  20. What is chronic cough in children?

    Directory of Open Access Journals (Sweden)

    Iulia eIOAN

    2014-08-01

    Full Text Available The cough reflex is modulated throughout growth and development. Cough – but not expiration reflex – appears to be absent at birth, but increases with maturation. Thus, acute cough is the most frequent respiratory symptom during the first few years of life. Later on, the pubertal development seems to play a significant role in changing of the cough threshold during childhood and adolescence resulting in sex-related differences in cough reflex sensitivity in adulthood. Asthma is the major cause of chronic cough in children. Prolonged acute cough is usually related to the long-lasting effects of a previous viral airway infection or to the particular entity called protracted bacterial bronchitis. Cough pointers and type may orient towards specific aetiologies, such as barking cough in croup or tracheomalacia, paroxystic whooping cough in Pertussis. Cough is productive in protracted bacterial bronchitis, sinusitis or bronchiectasis. Cough is usually associated with wheeze or dyspnea on exertion in asthma; however, it may be the sole symptom in cough variant asthma. Thus, paediatric cough has particularities differentiating it from adult cough, so the approach and management should be developmentally specific.

  1. Proteomic analysis of chicken embryonic trachea and kidney tissues after infection in ovo by avian infectious bronchitis coronavirus

    OpenAIRE

    Cao, Zhongzan; Han, Zongxi; Shao, Yuhao; Geng, Heyuan; Kong, Xiangang; Liu, Shengwang

    2011-01-01

    Background Avian infectious bronchitis (IB) is one of the most serious diseases of economic importance in chickens; it is caused by the avian infectious coronavirus (IBV). Information remains limited about the comparative protein expression profiles of chicken embryonic tissues in response to IBV infection in ovo. In this study, we analyzed the changes of protein expression in trachea and kidney tissues from chicken embryos, following IBV infection in ovo, using two-dimensional gel electropho...

  2. Add-on treatment with nebulized hypertonic saline in a child with plastic bronchitis after the Glenn procedure*, **

    OpenAIRE

    Lis, Grzegorz; Cichocka-Jarosz, Ewa; Jedynak-Wasowicz, Urszula; Glowacka, Edyta

    2014-01-01

    Plastic bronchitis (PB), although a rare cause of airway obstruction, has mortality rates up to 50% in children after Fontan-type cardiac surgery. We present the case of an 18-month-old female patient with PB following pneumonia. At 6 months of age, the patient underwent the Glenn procedure due to functionally univentricular heart. Fiberoptic bronchoscopy revealed complete blockage of the left bronchus by mucoid casts. Pharmacotherapy consisted of glucocorticosteroids, azithromycin, and enala...

  3. Proteomic analysis of chicken embryonic trachea and kidney tissues after infection in ovo by avian infectious bronchitis coronavirus

    OpenAIRE

    Kong Xiangang; Geng Heyuan; Shao Yuhao; Han Zongxi; Cao Zhongzan; Liu Shengwang

    2011-01-01

    Abstract Background Avian infectious bronchitis (IB) is one of the most serious diseases of economic importance in chickens; it is caused by the avian infectious coronavirus (IBV). Information remains limited about the comparative protein expression profiles of chicken embryonic tissues in response to IBV infection in ovo. In this study, we analyzed the changes of protein expression in trachea and kidney tissues from chicken embryos, following IBV infection in ovo, using two-dimensional gel e...

  4. Efficacy of Add-on Montelukast in Nonasthmatic Eosinophilic Bronchitis: The Additive Effect on Airway Inflammation, Cough and Life Quality

    OpenAIRE

    Bao, Wuping; Liu, Ping; Qiu, Zhongmin; Yu, Li; Hang, Jingqing; Gao, Xiaohua; Zhou, Xin

    2015-01-01

    Background: The efficacy of montelukast (MONT), a cysteinyl leukotriene receptor antagonist, in nonasthmatic eosinophilic bronchitis (NAEB), especially its influence on cough associated life quality is still indefinite. We evaluated the efficacy of MONT combined with budesonide (BUD) as compared to BUD monotherapy in improving life quality, suppressing airway eosinophilia and cough remission in NAEB. Methods: A prospective, open-labeled, multicenter, randomized controlled trial was conducted....

  5. Efficacy of Add-on Montelukast in Nonasthmatic Eosinophilic Bronchitis: The Additive Effect on Airway Inflammation, Cough and Life Quality

    OpenAIRE

    Wuping Bao; Ping Liu; Zhongmin Qiu; Li Yu; Jingqing Hang; Xiaohua Gao; Xin Zhou

    2015-01-01

    Background: The efficacy of montelukast (MONT), a cysteinyl leukotriene receptor antagonist, in nonasthmatic eosinophilic bronchitis (NAEB), especially its influence on cough associated life quality is still indefinite. We evaluated the efficacy of MONT combined with budesonide (BUD) as compared to BUD monotherapy in improving life quality, suppressing airway eosinophilia and cough remission in NAEB. Methods: A prospective, open-labeled, multicenter, randomized controlled trial was conduc...

  6. Synthesis of coronavirus mRNAs: kinetics of inactivation of infectious bronchitis virus RNA synthesis by UV light

    International Nuclear Information System (INIS)

    Infection of cells with the avian coronavirus infectious bronchitis virus results in the synthesis of five major subgenomic RNAs. These RNAs and the viral genome form a 3' coterminal nested set. We found that the rates of inactivation of synthesis of the RNAs by UV light were different and increased with the length of the transcript. These results show that each RNA is transcribed from a unique promoter and that extensive processing of the primary transcripts probably does not occur

  7. Cefditoren versus levofloxacin in patients with exacerbations of chronic bronchitis: serum inflammatory biomarkers, clinical efficacy, and microbiological eradication

    OpenAIRE

    Blasi F; Tarsia P; Mantero M; Morlacchi LC; Piffer F

    2013-01-01

    Francesco Blasi, Paolo Tarsia, Marco Mantero, Letizia C Morlacchi, Federico PifferDepartment of Pathophysiology and Transplantation, University of Milan, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Milan, ItalyBackground: The aim of this open-label, randomized, parallel-group pilot study was to evaluate the efficacy of cefditoren pivoxil and levofloxacin in terms of speed of reduction in inflammatory parameters, clinical recovery, and microbiological eradication.Metho...

  8. Clinical effectiveness and safety of gemifloxacin versus cefpodoxime in acute exacerbation of chronic bronchitis: A randomized, controlled trial

    Directory of Open Access Journals (Sweden)

    S Chatterjee

    2011-01-01

    Conclusion : The results of this randomized, single-blind trial demonstrated that a 7-day course of gemifloxacin is therapeutically comparable to cefpodoxime in terms of both clinical effectiveness and safety for the treatment of type II Anthonisen category AECB patients.

  9. URBAN AIR PARTICULATE INHALATION ALTERS PULMONARY FUNCTION AND INDUCES PULMONARY INFLAMMATION IN A RODENT MODEL OF CHRONIC BRONCHITIS. (R825242)

    Science.gov (United States)

    The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

  10. Cytokines in the pathogenesis of chronic obstructive pulmonary disease.

    Science.gov (United States)

    Reid, P T; Sallenave, J-M

    2003-01-01

    Chronic obstructive pulmonary disease (COPD) is a common cause of morbidity and mortality. The term is heterogenous and encompasses a number of distinct but often overlapping phenotypes including chronic bronchitis, small airways obstruction, emphysema and in some individuals, a systemic component. Although there have been significant advances in understanding the pathophysiology of COPD, understanding of the role of the inflammation in the pathogenesis of the condition remains in its infancy. Indeed, cytokines that are known to orchestrate the inflammatory response in asthma and other inflammatory diseases are only beginning to be reported in COPD. In this review, we highlight the potential role of cytokines in the development of mucus hypersecretion observed in chronic bronchitis and the morphological changes observed in the small airways and airspaces contributing to the development of airflow limitation and respiratory failure respectively. We report evidence that exacerbations are linked to increased expression of pro-inflammatory cytokines and that the wasting and skeletal muscle dysfunction observed in some patients is most probably related to the presence of a systemic inflammatory response. In addition transgenic and gene therapy technology has been used to explore the temporal and co-ordinated role of cytokines in the development of COPD animal models. Enhanced understanding of the events involved in the pathogenesis of COPD will lead to the development of therapy with potential to modify the observed progressive decline in lung function and impact on the development of the illness. PMID:12570672

  11. Role of Atypical Pathogens and the Antibiotic Prescription Pattern in Acute Bronchitis: A Multicenter Study in Korea.

    Science.gov (United States)

    Park, Sunghoon; Oh, Kil Chan; Kim, Ki-Seong; Song, Kyu-Tae; Yoo, Kwang Ha; Shim, Yun Su; Lee, Young Ju; Lee, Myung Goo; Yun, Jang Uk; Kim, Hyun Su; Kim, Yee Hyung; Lee, Won Jun; Kim, Do Il; Cha, Hyung Gun; Lee, Jae-Myung; Seo, Jung San; Jung, Ki-Suck

    2015-10-01

    The role of atypical bacteria and the effect of antibiotic treatments in acute bronchitis are still not clear. This study was conducted at 22 hospitals (17 primary care clinics and 5 university hospitals) in Korea. Outpatients (aged ≥ 18 yr) who had an acute illness with a new cough and sputum (≤ 30 days) were enrolled in 2013. Multiplex real-time polymerase chain reaction (RT-PCR) was used to detect five atypical bacteria. A total of 435 patients were diagnosed as having acute bronchitis (vs. probable pneumonia, n = 75), and 1.8% (n = 8) were positive for atypical pathogens (Bordetella pertussis, n = 3; B. parapertussis, n = 0; Mycoplasma pneumoniae, n = 1; Chlamydophila pneumoniae, n = 3; Legionella pneumophila, n = 1). Among clinical symptoms and signs, only post-tussive vomiting was more frequent in patients with atypical pathogens than those without (P = 0.024). In all, 72.2% of the enrolled patients received antibiotic treatment at their first visits, and β-lactams (29.4%) and quinolones (20.5%) were the most commonly prescribed agents. In conclusion, our study demonstrates that the incidence of atypical pathogens is low in patients with acute bronchitis, and the rate of antibiotic prescriptions is high. PMID:26425041

  12. CLINICAL OBSERVATION ON TREATMENT OF ACUTE BRONCHITIS PRIMARILY WITH PRICKING-CUPPING ON BACK-SHU POINTS

    Institute of Scientific and Technical Information of China (English)

    XU Wei-dong; ZHANG Yong-juan; YANG Jie; CHEN Xiao-xiang; LIU Yong-xiang

    2006-01-01

    Objective: To observe the clinical effect of treatment of acute bronchitis primarily with prickingcupping method on Back-shu points. Methods: The patients of acute bronchitis were randomly divided into 2groups. In the observation group, there were 36 cases, who were treated with the integrated traditional Chinese and western medicine, primarily the pricking-cupping method on Back-shu points; while in the control group, there were 29 cases who were given the conventinal treatment of western medicine. All the 2 groups were treated for 7 days as one treating course. Results: The total effective rate of the observation group was 97.2% while that of the control group was 82.8%, so there is a significant difference between them. On the first and third days the clinical manifestations were more satisfactorily improved in the treatment group than in the control group (P < 0.01 ) and on the fifth and seventh days, the comparison showed no significant difference (P >0.05). Conclusion: The treatment of acute bronchitis by means of the integrated traditional Chinese and western medicine primarily with pricking-cupping method on Back-shu points is of marked therapeutic effect, simple manipulation, and little untoward effects, thus claiming the unique advantage.

  13. Molecular detection of infectious bronchitis and avian metapneumoviruses in Oman backyard poultry.

    Science.gov (United States)

    Al-Shekaili, Thunai; Baylis, Matthew; Ganapathy, Kannan

    2015-04-01

    Infectious bronchitis virus (IBV) and avian metapneumovirus (aMPV) are economically important viral pathogens infecting chickens globally. Identification of endemic IBV and aMPV strains promotes better control of both diseases and prevents production losses. Orophrayngeal swab samples were taken from 2317 birds within 243 different backyard flocks in Oman. Swabs from each flock were examined by RT-PCR using part-S1 and G gene primers for IBV and aMPV respectively. Thirty-nine chicken flocks were positive for IBV. Thirty two of these were genotyped and they were closely related to 793/B, M41, D274, IS/1494/06 and IS/885/00. 793/B-like IBV was also found in one turkey and one duck flock. Five flocks were positive for aMPV subtype B. Though no disease was witnessed at the time of sampling, identified viruses including variant IBV strains, may still pose a threat for both backyard and commercial poultry in Oman. PMID:25613085

  14. Complete genomic sequence analysis of infectious bronchitis virus Ark DPI strain and its evolution by recombination

    Directory of Open Access Journals (Sweden)

    Gelb Jack

    2008-12-01

    Full Text Available Abstract An infectious bronchitis virus Arkansas DPI (Ark DPI virulent strain was sequenced, analyzed and compared with many different IBV strains and coronaviruses. The genome of Ark DPI consists of 27,620 nucleotides, excluding poly (A tail, and comprises ten open reading frames. Comparative sequence analysis of Ark DPI with other IBV strains shows striking similarity to the Conn, Gray, JMK, and Ark 99, which were circulating during that time period. Furthermore, comparison of the Ark genome with other coronaviruses demonstrates a close relationship to turkey coronavirus. Among non-structural genes, the 5'untranslated region (UTR, 3C-like proteinase (3CLpro and the polymerase (RdRp sequences are 100% identical to the Gray strain. Among structural genes, S1 has 97% identity with Ark 99; S2 has 100% identity with JMK and 96% to Conn; 3b 99%, and 3C to N is 100% identical to Conn strain. Possible recombination sites were found at the intergenic region of spike gene, 3'end of S1 and 3a gene. Independent recombination events may have occurred in the entire genome of Ark DPI, involving four different IBV strains, suggesting that genomic RNA recombination may occur in any part of the genome at number of sites. Hence, we speculate that the Ark DPI strain originated from the Conn strain, but diverged and evolved independently by point mutations and recombination between field strains.

  15. Progress and Challenges toward the Development of Vaccines against Avian Infectious Bronchitis

    Directory of Open Access Journals (Sweden)

    Faruku Bande

    2015-01-01

    Full Text Available Avian infectious bronchitis (IB is a widely distributed poultry disease that has huge economic impact on poultry industry. The continuous emergence of new IBV genotypes and lack of cross protection among different IBV genotypes have been an important challenge. Although live attenuated IB vaccines remarkably induce potent immune response, the potential risk of reversion to virulence, neutralization by the maternal antibodies, and recombination and mutation events are important concern on their usage. On the other hand, inactivated vaccines induce a weaker immune response and may require multiple dosing and/or the use of adjuvants that probably have potential safety risks and increased economic burdens. Consequently, alternative IB vaccines are widely sought. Recent advances in recombinant DNA technology have resulted in experimental IB vaccines that show promise in antibody and T-cells responses, comparable to live attenuated vaccines. Recombinant DNA vaccines have also been enhanced to target multiple serotypes and their efficacy has been improved using delivery vectors, nanoadjuvants, and in ovo vaccination approaches. Although most recombinant IB DNA vaccines are yet to be licensed, it is expected that these types of vaccines may hold sway as future vaccines for inducing a cross protection against multiple IBV serotypes.

  16. Replication of Infectious Bronchitis Virus in the Chicken Mesenchymal Stem Cells

    Directory of Open Access Journals (Sweden)

    M.H. Mohammed

    2012-06-01

    Full Text Available The susceptibility of the chicken mesenchymal stem cells to infectious bronchitis virus was characterized after twenty consecutive passages in chicken mesenchymal stemm cells. Virus replication was monitored by cytopathic observation, indirect immunoperoxidase, and reverse transcription polymerase chain reaction. At 72 h post-infection (p.i. in third passage, the cytopathic effect was characterized by rounding up of cell, monolayer detachment, intracytoplasmic brownish colouration was readily observed by from 24h p.i in third passage, and at all times the extracted viral RNA from IBV-infected monolayers was demonstrated by reverse transcription polymerase chain reaction. Tissue culture effective dose50 was used to measure virus titration performed on chicken mesenchymal stem cells and the titres in twenty passages was 108.6 TID50/ml. The results obtained in this study suggested that the chicken mesenhymal stem cells can be used for adaptation IBV and may be considered a step forward for the use of these cells in the future for IBV vaccine production

  17. S1 gene-based phylogeny of infectious bronchitis virus: An attempt to harmonize virus classification.

    Science.gov (United States)

    Valastro, Viviana; Holmes, Edward C; Britton, Paul; Fusaro, Alice; Jackwood, Mark W; Cattoli, Giovanni; Monne, Isabella

    2016-04-01

    Infectious bronchitis virus (IBV) is the causative agent of a highly contagious disease that results in severe economic losses to the global poultry industry. The virus exists in a wide variety of genetically distinct viral types, and both phylogenetic analysis and measures of pairwise similarity among nucleotide or amino acid sequences have been used to classify IBV strains. However, there is currently no consensus on the method by which IBV sequences should be compared, and heterogeneous genetic group designations that are inconsistent with phylogenetic history have been adopted, leading to the confusing coexistence of multiple genotyping schemes. Herein, we propose a simple and repeatable phylogeny-based classification system combined with an unambiguous and rationale lineage nomenclature for the assignment of IBV strains. By using complete nucleotide sequences of the S1 gene we determined the phylogenetic structure of IBV, which in turn allowed us to define 6 genotypes that together comprise 32 distinct viral lineages and a number of inter-lineage recombinants. Because of extensive rate variation among IBVs, we suggest that the inference of phylogenetic relationships alone represents a more appropriate criterion for sequence classification than pairwise sequence comparisons. The adoption of an internationally accepted viral nomenclature is crucial for future studies of IBV epidemiology and evolution, and the classification scheme presented here can be updated and revised novel S1 sequences should become available. PMID:26883378

  18. Molecular Characteristics of S1 Gene of Infectious Bronchitis Virus Isolated from Chicken Proventriculus

    Institute of Scientific and Technical Information of China (English)

    CHENG Li-qin; ZHOU Ji-yong; John Dikki; SHEN Xing-yan; CHEN Ji-gang; ZHANG De-yong

    2003-01-01

    Infectious bronchitis virus was isolated from swollen proventriculi of clinically ill chicken. Thesuspected virus samples (2/97, 3/97, 1/98) were adapted in SPF chicken embryos for virus isolation andidentification. All the virus isolates were able to agglutinate chicken erythrocytes after treatment with trypsin,and interfer with the reproduction of Newcastle disease virus in chicken embryos, and have low antigenic relat-edness values with reference positive IBV. The isolates 2/97, 3/97, 1/98 RNAs extracted from the allantoicfluid of inoculated embryonated eggs were converted to cDNA by reverse transcription with 3'-primer of S1gene of (IBV). Polymerase chain reaction (PCR) was performed with two primers which span the S1 gene.Amplified product of 1.93 kb was subjected to EcoR Ⅰ and BamH Ⅰ digestion and the fragments obtainedwere the same as expected size. The PCR product was ligated to pBlueScript-SK (+) vector, and its nucleotidesequence was determined by the dideoxy-mediated chain termination method. Nucleotide sequence analysisshowed 73.6 - 99.7 % homology between the isolated IBV and the IBV strains in GenBank. The homology ofamino acid was 71.4 - 99.4 %.

  19. Diagnostic and clinical observation on the infectious bronchitis virus strain Q1 in Italy

    Directory of Open Access Journals (Sweden)

    Anna Toffan

    2013-12-01

    Full Text Available This paper describes the diagnostic and clinical observations of an infectious bronchitis virus (IBV variant, referred to as Q1, in clinically ill chickens in Italy. This IBV variant was described for the first time in 1998 in China. In the autumn of 2011 it caused a small-scale epidemic in non-vaccinated meat chickens in farms located in Northern Italy. The disease was characterized by increased mortality, kidney lesions and proventriculitis. Histopatological observations confirmed the nephritis and described an unusual erosive/necrotic proventriculitis with infiltration of lymphocytes, plasma cells and heterophils, as well as fibroplasia in the lamina propria. Despite these findings and the isolation of the Q1 IB virus directly from proventricular tissue, further studies are necessary to confirm the role of this IBV strain in the development of proventricular lesions. Phylogenetic analysis revealed that all the IBV isolates were very similar and probably had a common origin. The IBV Q1 variant appears to be now endemic in the North of Italy and at times it is detected in vaccinated backyard and commercial broiler farms. The importance of continuous monitoring in controlling the spread of known or emerging IBV variants is underlined.

  20. TRYPSIN-INDUCED HEMAGGLUTINATION ASSAY FOR THE DETECTION OF INFECTIOUS BRONCHITIS VIRUS

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    M. S. Mahmood, M. Siddique, I. Hussain and A. Khan1

    2004-04-01

    Full Text Available A trypsin-induced hemagglutination (THA assay was standardized to detect infectious bronchitis virus (IBV in allantoic fluid (AF of embryonated eggs. The test was used in 20 samples, each collected from 5 different layer farms suspected for IBV. Allantoic fluid from inoculated embryos was harvested and treated with reagent grade trypsin at the percentages of 0.25, 0.50, 1.0 and 2.0 for 30 minutes to 3 hours at pH 7.2. The IBV in trypsinized AF was identified by clear and consistent agglutination of chicken red blood cells within 5 minutes of incubation at 37oC. The results indicated that AF treated with equal volume of 1.0% reagent grade trypsin elicited the hemagglutinating (HA activity in 3.0 hours whereas 2.0% reagent grade trypsin elicited the HA activity only after 30 minutes incubation at 37oC. Sensitivity of THA was 92% as compared with 76% for agar gel precipitation test. Gross pathological lesions (curling and dwarfing in chick embryo, intracereberal inoculation of un-weaned mice and pathogenicity test in one-day-old broiler chicks showed 79, 84 and 77% sensitivity, respectively.

  1. Peak flow as predictor of overall mortality in asthma and chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Hansen, Ejvind Frausing; Vestbo, Jørgen; Phanareth, K; Kok-Jensen, A; Dirksen, A

    Lung function is a strong predictor of overall mortality in asthma and chronic obstructive pulmonary disease (COPD). FEV1 is considered to be the "gold standard," whereas peak expiratory flow (PEF) is mostly used in absence of FEV1 measurements. We compared the predictive power of PEF and FEV1, m...... reflecting different components of COPD, i.e., chronic bronchitis, small airways disease, and emphysema. Furthermore, extrapulmonary components such as muscle mass and general "vigour" probably affect PEF to a greater extent than they affect FEV1....

  2. Hospital contacts for chronic diseases among danish seafarers and fishermen: a population-based cohort study

    DEFF Research Database (Denmark)

    Kaerlev, Linda; Dahl, Søren; Nielsen, Per Sabro;

    2007-01-01

    and the SHCR for chronic heart diseases was statistically significantly higher in the 1999 than in the 1994 cohort. For both time periods high SHCR values were found for bronchitis, emphysema, cancer of the lung, alcohol-related liver diseases, and diabetes among male non-officers, and lung cancer......, from 1 January 1994 and 1 January 1999, respectively, using rates specific for age and calendar time for the entire Danish workforce as a reference. RESULTS: The SHCRs for lung and cardiovascular diseases were high for non-officers. Among male officers, the SHCR for diabetes was high in the 1999 cohort...... among male officers. Among female non-officers, a high SHCR for skin melanomas was seen. Among fishermen high SHCRs for bronchitis, emphysema, lung cancer, and Raynaud's syndrome were found in both cohorts. No duration-response pattern was observed in any of the analyses, which may reflect health- and...

  3. Bronquitis infecciosa aviar: diagnóstico y control -Avian infectious bronchitis: diagnosis and control

    Directory of Open Access Journals (Sweden)

    Acevedo Beiras, Ana María

    2010-03-01

    Full Text Available ResumenLa bronquitis infecciosa aviar (BIA es una enfermedad que ocasiona unimpacto socio-económico severo en la industria avícola mundial. Es unaenfermedad respiratoria aguda, altamente contagiosa, caracterizadaprimariamente por signos respiratorios en los pollos en crecimiento. En las ponedoras, la sintomatología respiratoria es menor pero provoca una disminución marcada en la producción y calidad del huevo. El agente etiológico de esta enfermedad es el virus de la bronquitis infecciosa aviar, un Coronavirus del grupo 3 de la familia Coronaviridae, orden Nidovirales. El virus se replica en los tejidos del tracto respiratorio y en muchos tejidos a lo largo del tracto alimentario. Este virus puede infectar otras especies de aves además de los pollos. Los signos clínicos característicos son tos, estornudos, estertores traqueales, ojos acuosos, letargo y en los pollos, especialmente los jóvenes, se presentan descargas nasales. Estos signos son indicativos pero no tienen por sí solo valor diagnóstico y la confirmación requiere el aislamiento o la demostración directa de la presencia del virus aunque la serología puede ser útil en algunas circunstancias. El diagnóstico de laboratorio requiere el aislamiento viral y su identificación. Se emplean las técnicas de reacción en cadena de la polimerasa (RT-PCR, inhibición de la hemaglutinación (HI y ensayos inmunoenzimáticos (ELISA, así como la microscopía electrónica, anticuerpos monoclonales, virus neutralización (VN, inmunohistoquímica,ensayos de inmunofluorescencia y de inmunización desafío en pollos. Son ampliamente usadas vacunas vivas e inactivadas en el control de laenfermedad.SummaryAvian infectious bronchitis (BIA is a disease that provokes a severe socioeconomic impact in poultry world industry. It is a breathing sharp disease, highly contagious, characterized primarily for breathing signs in chickens in growth. In the egg-laying, the breathing sintomatology is

  4. Morphologic observations on respiratory tracts of chickens after hatchery infectious bronchitis vaccination and formaldehyde fumigation.

    Science.gov (United States)

    Di Matteo, A M; Soñez, M C; Plano, C M; von Lawzewitsch, I

    2000-01-01

    The histologic changes in the respiratory tracts of chickens were evaluated after hatchery fumigation with 40% formaldehyde vapors and vaccination against infectious bronchitis virus with live attenuated vaccine (Massachusetts serotype). One-day-old chickens were housed in four isolation units in controlled environmental conditions, fed and watered ad libitum, and separated into four groups: 1) fumigated and vaccinated birds (FV group); 2) nonfumigated and vaccinated birds (NFV group); 3) fumigated and nonvaccinated birds (FNV group); and 4) control group (C group). All birds were tested to be free from Mycoplasma gallisepticum and Mycoplasma synoviae. After necropsy on the first, eighth, and twenty-sixth days after birth, samples from tracheal upper portion and lungs were conventionally processed for light, scanning, and transmission electron microscopy. Tissue response was monitored by microscopic examination of trachea and lung. On the first day of observation, fumigated and vaccinated birds (FV group) showed extensively damaged tracheal epithelium with exfoliated areas and some active glands with electrodense granules, and in the lung, the primary bronchi epithelium had disorganized cilia and abundant lymphocytes, with emphysematous areas in tertiary bronchus. On day 8 after vaccination, cubical and cylindrical tracheal cell proliferation was observed, and on day 26, ciliated columnar epithelium was almost regenerated with heterophil corion infiltration, and hyaline cartilage nodules appeared in parabronchi. The nonfumigated and vaccinated birds (NFV) revealed less injury on the epithelial surface and a more rapid response to epithelial regeneration than the in only fumigated animals (FNV). The control group did not show remarkable morphologic changes. Postvaccinal and fumigation effects on the upper respiratory tract were temporary, whereas in lungs, increased emphysema, cartilage nodules in the interchange zone, and general lymphocyte infiltration had caused

  5. PREPARATION AND EVALUATION OF VITAMIN E ADJUVANTED OIL EMULSIFIED INFECTIOUS BRONCHITIS EXPERIMENTAL VACCINE

    Directory of Open Access Journals (Sweden)

    S. ALI, M. ARSHAD, M. SIDDIQUE AND M. ASHRAF

    2007-10-01

    Full Text Available The present study was conducted to prepare oil emulsified (OE infectious bronchitis (IB experimental vaccines. The vaccines were prepared using the vaccinal strain H-120 Infectious Bonchitis virus (IBV. The virus was cultivated in 9-day old embryonated eggs via allantoic cavity route. Allantoic-amniotic fluid (AAF was collected and inactivated with formalin @ 0.12%. Water in oil emulsion was prepared by adding one part of AAF to four parts of mineral oil containing water phase (Tween 80 and oil phase (Span 80 surfactants. Hydrophile lypohile balance (HLB of the emulsion was maintained at 7.0. Two oil emulsified experimental vaccines were prepared. Vaccine-I was prepared without vitamin E and Vaccine-II with vitamin E (300 mg/ml. A total of 120 day-old broiler breeder chickens were divided into 4 groups, A, B, C, and D, each having 30 birds. At the age of 21 days, experimental Vaccine-I, experimental vaccine-II and commercial IB killed (H-120 vaccine were inoculated @ 0.5 ml in the birds of groups A, B and C, respectively. Group D was maintained as nonvaccinated control. Efficacy of the vaccines was evaluated on the basis of humoral immune response (haemagglutination inhibition antibody titres against IB in the four groups. The seven weeks cumulative mean antibody titres (CMT of each group were calculated. The highest CMT was observed in group B (130, followed by group C (69, group A (58 and group D (17. Statistical analysis showed that haemagglutination inhibition (HI antibody titres in group B (vaccine- II were significantly higher than those of groups A, B and C (P< 0.05.

  6. Genotyping of infectious bronchitis viruses from broiler farms in Iraq during 2014-2015.

    Science.gov (United States)

    Seger, Waleed; GhalyanchiLangeroudi, Arash; Karimi, Vahid; Madadgar, Omid; Marandi, Mehdi Vasfi; Hashemzadeh, Masoud

    2016-05-01

    Infectious bronchitis virus (IBV) is one of the most critical pathogens in the poultry industry, causing serious economic losses in all countries including Iraq. IBV has many genotypes that do not confer any cross-protection. This virus has been genotyped by sequence analysis of the S1 glycoprotein gene. A total of 100 tracheal and kidney tissue specimens from different commercial broiler flocks in the middle and south of Iraq were collected from September 2013 to September 2014. Thirty-two IBV-positive samples were selected from among the total and were further characterized by nested PCR. Phylogenetic analysis revealed that isolates belong to four groups (group I, variant 2 [IS/1494-like]; group II, 793/B-like; group III, QX-like; group IV, DY12-2-like). Sequence analysis revealed nucleotide sequence identities within groups I, II, and III of 99.68 %-100 %, 99.36 %-100 %, and 96.42 %-100 %, respectively. Group I (variant 2) was the dominant IBV genotype. One Chinese-like recombinant virus (DY12-2-like) that had not been reported in the Middle East was detected. In addition, the presence of QX on broiler chicken farms in the area studied was confirmed. This is the first comprehensive study on the genotyping of IBV in Iraq with useful information regarding the molecular epidemiology of IBV. The phylogenetic relationship of the strains with respect to different time sequences and geographical regions displayed complexity and diversity. Further studies are needed and should include the isolation and full-length molecular characterization of IBV in this region. PMID:26887967

  7. Increasing awareness of recognition of chronic obstructive pulmonary disease

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ The medical community should, by now, be well aware of the importance of chronic obstructive pulmonary disease (COPD), an increasingly common condition with high morbidity and mortality. In modern terms, COPD has come to signify concurrent chronic bronchitis, asthmatic bronchitis and emphysema. Cigarette smoking has long been recognized as the predominant aetiological agent. Arterial hypoxaemia, a frequent complication of COPD, can lead to pulmonary hypertension and cor pulmonale. COPD affects over 5% of the adult population and is the only major cause of death whose morbidity and mortality are increasing in several countries.1 In China, it is difficult to quantify how many people are affected with COPD. However, a recent epidemiological survey indicated that COPD prevalence was 8.2% in China. COPD prevalence in men was significantly higher than in women (12.4% cf 5.1%). The prevalence in rural areas was higher than that in urban areas (8.8% cf 7.8%). Of patients with COPD, 61.5% were smokers. The report also stated that COPD is the major cause of death in rural areas in China and the fourth leading cause of death in urban areas, rising to the third leading cause of death by 2020.2 The prevalence of the disease increases with age with highest rates seen in people over the age of 70 years. COPD is the only major cause of mortality with a rising incidence and prevalence worldwide, rendering it an increasingly worrisome

  8. In Vitro and In Ovo Expression of Chicken Gamma Interferon by a Defective RNA of Avian Coronavirus Infectious Bronchitis Virus

    OpenAIRE

    Hackney, Karen; Cavanagh, Dave; Kaiser, Pete; Britton, Paul

    2003-01-01

    Coronavirus defective RNAs (D-RNAs) have been used for site-directed mutagenesis of coronavirus genomes and for expression of heterologous genes. D-RNA CD-61 derived from the avian coronavirus infectious bronchitis virus (IBV) was used as an RNA vector for the expression of chicken gamma interferon (chIFN-γ). D-RNAs expressing chIFN-γ were shown to be capable of rescue, replication, and packaging into virions in a helper virus-dependent system following electroporation of in vitro-derived T7 ...

  9. Clinical significance of determination of changes of serum SOD, TNF-α levels and T-cell subsets distribution type after treatment in pediatric patients with acute bronchitis

    International Nuclear Information System (INIS)

    Objective: To study the changes of serum SOD, TNF-α levels and T-cell subsets distribution type after treatment in pediatric patients with acute bronchitis. Methods: Serum SOD, TNF-α levels (with RIA) and T-cell subsets distribution type (with monoclonal antibody technique) were detected both before and after treatment in 39 pediatric patients with acute bronchitis as well as in 35 controls. Results: Before treatment, the serum levels of SOD, CD4/CD8 ratios were significantly lower and serum TNF-α levels significantly higher in the patients than those in the controls (P0.05). Conclusion: Determination of serum SOD, TNF-α levels and T-cell subsets distribution type is clinically meaningful in pediatric patients with acute bronchitis. (authors)

  10. Ameliorative effect of a microbial feed additive on infectious bronchitis virus antibody titer and stress index in broiler chicks fed deoxynivalenol.

    Science.gov (United States)

    Ghareeb, K; Awad, W A; Böhm, J

    2012-04-01

    Although acute mycotoxicoses are rare in poultry production, chronic exposure to low levels of mycotoxins is responsible for reduced productivity and increased susceptibility to infectious diseases. Deoxynivalenol (DON) is known to modulate immune function, but only a few studies have investigated the effect of DON on the vaccinal immune response. In addition, the effects of Mycofix select (Biomin GmbH, Herzogenburg, Austria) supplementation to DON-contaminated broiler diets have not yet been demonstrated. Therefore, an experiment with 1-d-old male broilers (Ross 308) was carried out to examine the effects of feeding DON-contaminated low-protein grower diets on performance, serum biochemical parameters, lymphoid organ weight, and antibody titers to infectious bronchitis vaccination in serum and to evaluate the effects of Mycofix select dietary supplementation in either the presence or absence of DON in broilers. In total, thirty-two 1-d-old broiler chicks were randomly assigned to 1 of the 4 dietary treatments for 5 wk. The dietary treatments were 1) control; 2) artificially contaminated diets with 10 mg of DON/kg of diet; 3) DON-contaminated diets supplemented with Mycofix select; and 4) control diet supplemented with Mycofix select. Feeding of contaminated diets decreased (P = 0.000) the feed intake, BW (P = 0.001), BW gain (P = 0.044), and feed efficiency during the grower phase. Deoxynivalenol affected the blood biochemistry, whereas plasma total protein and uric acid concentrations in birds fed contaminated grains were decreased compared with those of the controls. Moreover, in birds fed contaminated feeds, there was a tendency to reduce triglycerides in the plasma (P = 0.090), suggesting that DON in the diets affected protein and lipid metabolism in broiler chickens. The feeding of contaminated diets altered the immune response in broilers by reducing the total lymphocyte count. Similarly, the antibody response against infectious bronchitis vaccination

  11. High-resolution CT in patients with chronic airflow obstruction: correlation with clinical diagnosis and pulmonary function test

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Ki Taek; Kang, Eun Young; Rhee, Ji Yong; Kim, Jin Hyung; Choi, Jung Ah; Cho, Jae Yoen; Oh, Yu Whan; Suh, Won Hyuck [College of Medicine, Korea University, Seoul (Korea, Republic of)

    2000-06-01

    To determine the utility of HRCT in the diagnosis of chronic airflow obstruction and to correlate the morphologic abnormalities revealed by this modality with functional impairment in patients with chronic airflow obstruction. This study involved 80 patients with chronic airflow obstruction who underwent HRCT and a pulmonary function test. Final clinical diagnosis in these patients was determined by a chest physician on the basis of clinical features, bronchoscopy, pulmonary function test, and HRCT. In order to diagnose and determine the extent of areas of decreased attenuation revealed by HRCT (the CT score), the findings of HRCT were retrospectively reviewed by two radiologists, who reached a consensus. Clinical and HRCT diagnoses were then compared, and the rate of agreement between them was calculated. The relationship between the extent of areas of decreased attenuation revealed by HRCT and by FEV1/FVC was evaluated using Correl's account and Student's unpaired t-test. The agreement rate between clinical and HRCT diagnoses was 77.5% (62/80). The rates for bronchiectasis (88.9%, 24/27), emphysema (93.9%, 31/33), and bronchiolitis obliterans (100%, 6/6) were considerably higher than those for chronic bronchitis and bronchial asthma. The correlation rate between CT score and FEV1/FVC was significant in bronchiectasis (p less than 0.05; r: -0.76) and bronchiolitis obliterans (p less than 0.01; r: -0.66), but not in cases involving emphysema, bronchial asthma, or chronic bronchitis (p greater than 0.05). HRCT is valuable in the diagnosis and prediction of physiologic impairment in patients with bronchiectasis and bronchiolitis obliterans, but has limited value in those with emphysema, chronic bronchitis or asthma. (author)

  12. High-resolution CT in patients with chronic airflow obstruction: correlation with clinical diagnosis and pulmonary function test

    International Nuclear Information System (INIS)

    To determine the utility of HRCT in the diagnosis of chronic airflow obstruction and to correlate the morphologic abnormalities revealed by this modality with functional impairment in patients with chronic airflow obstruction. This study involved 80 patients with chronic airflow obstruction who underwent HRCT and a pulmonary function test. Final clinical diagnosis in these patients was determined by a chest physician on the basis of clinical features, bronchoscopy, pulmonary function test, and HRCT. In order to diagnose and determine the extent of areas of decreased attenuation revealed by HRCT (the CT score), the findings of HRCT were retrospectively reviewed by two radiologists, who reached a consensus. Clinical and HRCT diagnoses were then compared, and the rate of agreement between them was calculated. The relationship between the extent of areas of decreased attenuation revealed by HRCT and by FEV1/FVC was evaluated using Correl's account and Student's unpaired t-test. The agreement rate between clinical and HRCT diagnoses was 77.5% (62/80). The rates for bronchiectasis (88.9%, 24/27), emphysema (93.9%, 31/33), and bronchiolitis obliterans (100%, 6/6) were considerably higher than those for chronic bronchitis and bronchial asthma. The correlation rate between CT score and FEV1/FVC was significant in bronchiectasis (p less than 0.05; r: -0.76) and bronchiolitis obliterans (p less than 0.01; r: -0.66), but not in cases involving emphysema, bronchial asthma, or chronic bronchitis (p greater than 0.05). HRCT is valuable in the diagnosis and prediction of physiologic impairment in patients with bronchiectasis and bronchiolitis obliterans, but has limited value in those with emphysema, chronic bronchitis or asthma. (author)

  13. Anti-inflammatory effects of myrtol standardized and other essential oils on alveolar macrophages from patients with chronic obstructive pulmonary disease

    OpenAIRE

    Rantzsch U; Vacca G; Dück R; Gillissen A

    2009-01-01

    Abstract Introduction Myrtol standardized is established in the treatment of acute and chronic bronchitis and sinusitis. It increases mucociliar clearance and has muco-secretolytic effects. Additional anti-inflammatory and antioxidative properties have been confirmed for Myrtol standardized, eucalyptus oil, and orange oil in several in vitro studies. Objective The aim of this study was to prove the ability of essential oils to reduce cytokines release and reactive oxygen species (ROS) product...

  14. Purification, crystallization and preliminary X-ray analysis of nonstructural protein 2 (nsp2) from avian infectious bronchitis virus

    International Nuclear Information System (INIS)

    Nonstructural protein 2 from avian infectious bronchitis virus has been overexpressed in E. coli, purified and crystallized. Diffraction data were collected to 2.8 Å resolution. Avian infectious bronchitis virus (IBV) is a member of the group III coronaviruses, which differ from the other groups of coronaviruses in that they do not encode the essential pathogenic factor nonstructural protein 1 (nsp1) and instead start with nsp2. IBV nsp2 is one of the first replicase proteins to be translated and processed in the viral life cycle; however, it has an entirely unknown function. In order to better understand the structural details and functional mechanism of IBV nsp2, the recombinant protein was cloned, overexpressed in Escherichia coli, purified and crystallized. The crystals diffracted to 2.8 Å resolution and belonged to space group P21, with unit-cell parameters a = 57.0, b = 192.3, c = 105.7 Å, β = 90.8°. Two molecules were found in the asymmetric unit; the Matthews coefficient was 3.9 Å3 Da−1, corresponding to a solvent content of 68.2%

  15. The Nature and Causes of Chronic Obstructive Pulmonary Disease: A Historical Perspective

    Directory of Open Access Journals (Sweden)

    C Peter W Warren

    2009-01-01

    Full Text Available Chronic obstructive pulmonary disease (COPD is the currently favoured name for the diseases formerly known as emphysema and bronchitis. COPD has been recognized for more than 200 years. Its cardinal symptoms are cough, phlegm and dyspnea, and its pathology is characterized by enlarged airspaces and obstructed airways. In the 19th century, the diagnosis of COPD depended on its symptoms and signs of a hyperinflated chest, and reduced expiratory breath sounds. The airflow obstruction evident on spirometry was identified in that century, but did not enter into clinical practice. Bronchitis, and the mechanical forces required to overcome its obstruction, was believed to be responsible for emphysema, although the inflammation present was recognized. The causes of bronchitis, and hence emphysema, included atmospheric and domestic air pollution, as well as dusty occupations. Cigarette smoking only became recognized as the dominant cause in the 20th century. The lessons learned of the risks for COPD in 19th-century Britain are very pertinent to the world today.

  16. Currently available cough suppressants for chronic cough.

    Science.gov (United States)

    Chung, Kian Fan

    2008-01-01

    Chronic cough is a common symptom but only a fraction of patients seek medical attention. Addressing the causes of chronic cough may lead to control of cough; however, this approach is not always successful since there is a certain degree of failure even when the cause(s) of cough are adequately treated; in idiopathic cough, there is no cause to treat. Persistent cough may be associated with deterioration of quality of life, and treatment with cough suppressants is indicated. Currently available cough suppressants include the centrally acting opioids such as morphine, codeine, and dextromethorphan. Peripherally acting antitussives include moguisteine and levodropropizine. Early studies report success in reducing cough in patients with chronic bronchitis or COPD; however, a carefully conducted study showed no effect of codeine on cough of COPD. Success with these cough suppressants can be achieved at high doses that are associated with side effects. Slow-release morphine has been reported to be useful in controlling intractable cough with good tolerance to constipation and drowsiness. There have been case reports of the success of centrally acting drugs such as amitryptiline, paroxetine, gabapentin, and carbamezepine in chronic cough. New opioids such as nociceptin or antagonists of TRPV1 may turn out to be more effective. Efficacy of cough suppressants must be tested in double-blind randomised trials using validated measures of cough in patients with chronic cough not responding to specific treatments. Patients with chronic cough are in desperate need of effective antitussives that can be used either on demand or on a long-term basis. PMID:17909897

  17. Chronic gastritis

    OpenAIRE

    Sipponen, Pentti; Maaroos, Heidi-Ingrid

    2015-01-01

    Abstract Prevalence of chronic gastritis has markedly declined in developed populations during the past decades. However, chronic gastritis is still one of the most common serious pandemic infections with such severe killing sequelae as peptic ulcer or gastric cancer. Globally, on average, even more than half of people may have a chronic gastritis at present. Helicobacter pylori infection in childhood is the main cause of chronic gastritis, which microbial origin is the key for the understand...

  18. Invasive Aspergillus infections in hospitalized patients with chronic lung disease

    Directory of Open Access Journals (Sweden)

    Wessolossky M

    2013-05-01

    Full Text Available Mireya Wessolossky,1 Verna L Welch,2 Ajanta Sen,1 Tara M Babu,1 David R Luke21Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, MA, USA; 2Medical Affairs, Pfizer Inc, Collegeville, PA, USABackground: Although invasive pulmonary aspergillosis (IPA is more prevalent in immunocompromised patients, critical care clinicians need to be aware of the occurrence of IPA in the nontraditional host, such as a patient with chronic lung disease. The purpose of this study was to describe the IPA patient with chronic lung disease and compare the data with that of immunocompromised patients.Methods: The records of 351 patients with Aspergillus were evaluated in this single-center, retrospective study for evidence and outcomes of IPA. The outcomes of 57 patients with chronic lung disease and 56 immunocompromised patients were compared. Patients with chronic lung disease were defined by one of the following descriptive terms: emphysema, asthma, idiopathic lung disease, bronchitis, bronchiectasis, sarcoid, or pulmonary leukostasis.Results: Baseline demographics were similar between the two groups. Patients with chronic lung disease were primarily defined by emphysema (61% and asthma (18%, and immunocompromised patients primarily had malignancies (27% and bone marrow transplants (14%. A higher proportion of patients with chronic lung disease had a diagnosis of IPA by bronchoalveolar lavage versus the immunocompromised group (P < 0.03. The major risk factors for IPA were found to be steroid use in the chronic lung disease group and neutropenia and prior surgical procedures in the immunocompromised group. Overall, 53% and 69% of chronic lung disease and immunocompromised patients were cured (P = 0.14; 55% of chronic lung patients and 47% of immunocompromised patients survived one month (P = 0.75.Conclusion: Nontraditional patients with IPA, such as those with chronic lung disease, have outcomes and mortality similar to that in the

  19. Chronic prostatitis

    OpenAIRE

    Erickson, Bradley A.; Schaeffer, Anthony J.; Le, Brian

    2008-01-01

    Chronic prostatitis can cause pain and urinary symptoms, and usually occurs without positive bacterial cultures from prostatic secretions (known as chronic abacterial prostatitis or chronic pelvic pain syndrome, CP/CPPS). Bacterial infection can result from urinary tract instrumentation, but the cause and natural history of CP/CPPS are unknown.

  20. Multi-centre retrospective analysis of clinical diagnosis and treatment for chronic cough

    Directory of Open Access Journals (Sweden)

    Xiao-ming CHENG

    2011-02-01

    Full Text Available Objective To explore the clinical characteristics and the present status of diagnosis and treatment of chronic cough.Methods The clinical data of 238 in-patients and out-patients of Departments of Respiratory Diseases from 4 teaching hospitals of Chongqing Municipality were collected from Oct.2008 to Dec.2009,and their clinical characteristics,diagnosis and therapeutic effects were retrospectively analyzed.Results A total of 238 patients were enrolled,most of them complained of dry cough and night cough.Throat symptoms were most common,including itching or foreign body sensation,throat discomfort and gastro-oesophageal reflux.Congestion of pharynx and cobblestone like changes in posterior pharyngeal wall were the most common signs in patients with chronic cough.Among all the supplementary examinations,bronchial provocation test resulted in highest positive rate.Etiological diagnosis was done in a total of 254 case-times for diseases leading to chronic cough,among them upper airway cough syndrome(UACS was suspected in 115 case-times.cough variant asthma(CVA in 42 case-times,and cough due to gastroesophageal reflux(GERC in 53 case-times.After the specific treatment targeting UACS,CVA and GERC,in 152 case-times improvement was found after follow-up,including 56,27 and 21 case-times,respectively,with an effective rate of 68.4%(104/152.The final diagnosis for the other 44 case-times with chronic cough was chronic tonsillitis,chronic bronchitis,eosinophilic bronchitis and angiotensin converting enzyme inhibitor(ACEI induced cough.A definite diagnosis was finally made in 148 out of a total of 254 casses,with a diagnostic rate of 58.3%(148/254.Conclusion The final diagnostic rate in etiology of chronic cough is still poor nowadays in our country,and empirical treatment is still the main practice for chronic cough.

  1. DEVELOPMENT AND EVALUATION OF A REAL-TIME TAQMAN RT-PCR ASSAY FOR THE DETECTION OF INFECTIOUS BRONCHITIS VIRUS FROM INFECTED CHICKENS

    Science.gov (United States)

    It is important to rapidly differentiate infectious bronchitis virus (IBV) from disease agents like highly pathogenic avian influenza virus and exotic Newcastle disease virus, because those diseases can be extremely similar in the early stages of their pathogenicity. In this study, we report the dev...

  2. Detection and strain differentiation of infectious bronchitis virus in tracheal tissues from experimentally infected chickens by reverse transcription-polymerase chain reaction. Comparison with an immunohistochemical technique

    DEFF Research Database (Denmark)

    Handberg, Kurt; Nielsen, O.L.; Pedersen, M.W.; Jørgensen, Poul Henrik

    1999-01-01

    Oligonucleotide pairs were constructed for priming the amplification of fragments of nucleocapsid (N) protein and spike glycoprotein (S) genes of avian infectious bronchitis virus (IBV) by reverse transcription-polymerase chain reaction (RT-PCR). One oligonucleotide pair amplified a common segment...

  3. Diagnosis of Infectious Bronchitis Disease in Broiler Chickens by Serological Test (ELISA and RT-PCR in Duhok

    Directory of Open Access Journals (Sweden)

    Dyar Adil Morad AL-Barwary

    2012-02-01

    Full Text Available Infectious Bronchitis (IB is one of the most important viral diseases of poultry and it causes major economic losses in poultry industry. The study was conducted to detect Infectious Bronchitis virus (IBV in broilers chicken farms in Duhok Governorate. To achieve this goal two tests have been used throughout the study protocol Enzyme-Linked Immunosorbent Assay (ELISA and Reverse Transcription Polymerase Chain Reaction (RT-PCR. One hundred and eighty Serum samples were collected from 11 chicken farms including (120 samples from 9 symptomatic non vaccinated chicken farms, (30 samples from one asymptomatic vaccinated chicken farm and another (30 samples from one asymptomatic non vaccinated chicken farm and screened for the presence of IBV antibodies by ELISA kit. The total RNAs were extracted from tracheal tissues using RNX TM-Plus reagent (Cinnagen,Iran. Eighty serum samples were positive: 50/120 (41.6% sample were symptomatic non vaccinated, another 30/30 (100% were asymptomatic vaccinated chickens samples, and the remaining samples (100 were negative by ELISA , including 70 /120 (58.4% from symptomatic non vaccinated chickens, and 30/30 (100% from asymptomatic non vaccinated chickens. The molecular detection of avian infectious bronchitis virus by use of RT-PCR was applied to extract RNAs from tracheal tissues. The test was performed on (80 symptomatic non vaccinated chickens and 36 vaccinated and non vaccinated chickens. Detection was performed using universal types of primers including XCE2+ and XCE2- 80 symptomatic chickens were examined by RT-PCR (50 with positive ELISA and 30 with negative ELISA results, 36 (44.4 % have detectable IBV-cDNA and the remaining 44 (55.6% did not have detectable IBVcDNA. Another 36 (18 asymptomatic vaccinated and 18 non vaccinated chickens were examined by RT-PCR, 8 (22.2% have detectable IBV-cDNA, and the remaining 28 (77.8% were negative. This study has determined the presences of IBV in flocks of Duhok

  4. Infectious bronchitis in Brazilian chickens: current data and observations of field service personnel

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    EN Silva

    2010-09-01

    Full Text Available The infectious bronchitis virus (IBV was detected for the first time in Brazil by Hipólito in 1957 in chickens sold life in the municipal market of Belo Horizonte, MG, when commercial poultry production was just starting in that country. The Massachusetts (Mass serotype was identified. However, the clinical disease was only observed in 1975, when poultry production was intensely growing. The extensive outbreak produced the classical condition in layers and breeders, affecting egg production and quality, whereas broilers presented respiratory and "nephritis-nephrosis" signs. The disease rapidly spread to all poultry-producing regions in the country, and in 1979, both the imports and the manufacturing of live vaccines against IB strains Mass, H120 and H52, were licensed. In 1980, inactivated vaccines were introduced. Molecular techniques, particularly PCR, started to bed in the identification of IBV. A retrospective analysis showed that, up to 1989, the main IBV strain circulating in Brazil was Mass. However, other studies shows the presence of a wide diversity of IBV strains in Brazil since the first strains were isolated, even before vaccination was introduced. Most researchers agree that the incidence of IBV different from Mass has increased, including of exclusively Brazilian genotypes, different from those described in other countries. Indeed, during the last few years, the number of genotypical variants has been much higher than that of the classical Mass serotype. Clinically, in addition of the classic presentations, atypical forms such as testicular atrophy and stones in the epidydimis associated to low fertility have been described. Serological techniques started to be used in vaccination monitoring and as a diagnostic tool. Serological response standards were developed, and have shown to be very useful to determine the expected profile in vaccination programs and when clinical disease is suspected. However, the immuno-enzymatic test

  5. Otras enfermedades obstructivas: bisinosis, bronquitis crónica y EPOC de origen laboral y bronquitis eosinofílica Other obstructive diseases: byssinosis, chronic bronchitis and occupational COPD and eosinophilic bronchitis

    OpenAIRE

    F. J. Michel De la Rosa; B. Fernández Infante

    2005-01-01

    Además del asma ocupacional y las enfermedades derivadas de la inhalación aguda, otras enfermedades obstructivas también reconocen un origen laboral. Aunque en la actualidad la bisinosis es una enfermedad rara en España, describimos las características de la misma por su interés histórico dentro de las enfermedades respiratorias de origen laboral y porque todavía sigue vigente en los países en vías de desarrollo. La bronquitis crónica también puede estar relacionada con la exposición laboral ...

  6. Pathophysiological Implication of Computed Tomography Images of Chronic Pulmonary Aspergillosis.

    Science.gov (United States)

    Ando, Tsunehiro; Tochigi, Naobumi; Gocho, Kyoko; Moriya, Atsuko; Ikushima, Soichiro; Kumasaka, Toshio; Takemura, Tamiko; Shibuya, Kazutoshi

    2016-03-23

    Chronic pulmonary aspergillosis (CPA) is a refractory disorder that needs long-term antifungal treatment and occasionally results in fatal respiratory failure and hemoptysis. However, the pathological features of the disorder have not been thoroughly delineated. Thirty cases were therefore analyzed clinically and histologically to elucidate the pathophysiology of CPA. The subjects comprised 14 individuals who underwent surgical removal and 16 patients who died. No subject exhibited a severely immunocompromised state. The main symptoms included cough, hemosputum, and dyspnea. Chest computed tomography (CT) findings revealed a cavity, fungus ball, and consolidation and/or ground glass opacity (GGO); 27 serial CT scans showed enlarged consolidation and/or GGO (70%), dilatation of the cavity (26%), and extension to the opposite lung (22%). Histopathological findings revealed a cavity with ulceration, bronchitis, and various degrees of organizing pneumonia (OP) that were correlated with the area of consolidation and GGO on the CT scan. The essential pathophysiology of CPA can be understood as an active state of ulceration of the cavity and/or erosive bronchitis caused by contact with the fungus ball, which may play a significant role in the development of OP. Consequently, OP is thought to reflect respiratory failure that relates to the prognosis of CPA. PMID:26166500

  7. [Effects of oxygen therapy on the hematocrit value in hypoxemic, chronic bronchopneumopathies].

    Science.gov (United States)

    Fumagalli, G; Ferrara, A; Gangarossa, C

    1974-12-22

    Changes in haematocrit values were studied in hypoxaemic chronic bronchitis patients subjected to oxygen-therapy. A statistically significant decrease was observed in all cases after respiration of oxygen. This was partly attributable to resolution of vasoconstrictive reflexes imposed by prior oxygen starvation, due to shifting of part of the circulating mass from the systemic to the pulmonary circulation, and partly to improved ventilation yield; this, couplled with reduced cardiac frequency and output, facilitates a more efficient thoracic aspiration of the reflux blood. PMID:4449623

  8. Add-on treatment with nebulized hypertonic saline in a child with plastic bronchitis after the Glenn procedure

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    Grzegorz Lis

    2014-01-01

    Full Text Available Plastic bronchitis (PB, although a rare cause of airway obstruction, has mortality rates up to 50% in children after Fontan-type cardiac surgery. We present the case of an 18-month-old female patient with PB following pneumonia. At 6 months of age, the patient underwent the Glenn procedure due to functionally univentricular heart. Fiberoptic bronchoscopy revealed complete blockage of the left bronchus by mucoid casts. Pharmacotherapy consisted of glucocorticosteroids, azithromycin, and enalapril maleate. The child also received nebulized 3% NaCl solution, which proved to be beneficial. In children submitted to Fontan-type procedures, physicians must be alert for PB, which can be triggered by respiratory tract infection.

  9. Reverse transcription loop-mediated isothermal amplification for the rapid detection of infectious bronchitis virus in infected chicken tissues.

    Science.gov (United States)

    Chen, Hao-tai; Zhang, Jie; Ma, Yan-ping; Ma, Li-Na; Ding, Yao-zhong; Liu, Xiang-tao; Cai, Xue-peng; Ma, Li-qing; Zhang, Yong-guang; Liu, Yong-sheng

    2010-04-01

    A reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay targeting the nucleocapsid phosphoprotein gene of infectious bronchitis virus (IBV) was developed. The detection limits for the IBV RT-LAMP assay were 10(1) 50% egg infection dose (EID(50)) per 50 microl of titrated viruses and no cross-reaction of IBV RT-LAMP was found when tested with other viruses including Newcastle disease virus (NDV), avian reovirus (ARV), and infectious laryngotrachietis virus (ILTV) due to their mismatch with IBV RT-LAMP primers. A total of 187 clinical tissues samples (88 blood, 62 kidney and 37 lung) were evaluated and compared to conventional RT-PCR. The sensitivity of RT-LAMP and RT-PCR assays for detecting IBV RNA in clinical specimens was 99.5% and 98.4%, respectively. These findings showed that the RT-LAMP assay has potential usefulness for rapid and sensitive diagnosis in outbreak of IBV. PMID:19835950

  10. Sialic Acid Binding Properties of Soluble Coronavirus Spike (S1 Proteins: Differences between Infectious Bronchitis Virus and Transmissible Gastroenteritis Virus

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    Christine Winter

    2013-07-01

    Full Text Available The spike proteins of a number of coronaviruses are able to bind to sialic acids present on the cell surface. The importance of this sialic acid binding ability during infection is, however, quite different. We compared the spike protein of transmissible gastroenteritis virus (TGEV and the spike protein of infectious bronchitis virus (IBV. Whereas sialic acid is the only receptor determinant known so far for IBV, TGEV requires interaction with its receptor aminopeptidase N to initiate infection of cells. Binding tests with soluble spike proteins carrying an IgG Fc-tag revealed pronounced differences between these two viral proteins. Binding of the IBV spike protein to host cells was in all experiments sialic acid dependent, whereas the soluble TGEV spike showed binding to APN but had no detectable sialic acid binding activity. Our results underline the different ways in which binding to sialoglycoconjugates is mediated by coronavirus spike proteins.

  11. The detection of cytotoxic lymphocyte activity in chickens infected with infectious bronchitis virus or fowl pox virus.

    Science.gov (United States)

    Chubb, R C; Huynh, V; Law, R

    1987-01-01

    A cytotoxic lymphocyte assay, using cells that adhered to plastic as the target cells and neutral red as the indicator for lysis, was applied to chickens infected with either infectious bronchitis virus or fowl pox virus. Both target and effector cells were derived from the same bird. Cytotoxic lymphocytes were generated in birds infected with either virus. The activity was confined to cells of the spleen after initial immunisation, but could be detected in white cells from the blood after challenge at a peripheral site, with both virulent and avirulent virus strains. It is likely that the cytotoxic cells are T-lymphocytes. The cytotoxic assay system used was an economical and convenient method for chickens which overcame the need for inbred lines of birds. PMID:18766629

  12. Adjuvant Activity of Sargassum pallidum Polysaccharides against Combined Newcastle Disease, Infectious Bronchitis and Avian Influenza Inactivated Vaccines

    Directory of Open Access Journals (Sweden)

    Li-Jie Li

    2012-11-01

    Full Text Available This study evaluates the effects of Sargassum pallidum polysaccharides (SPP on the immune responses in a chicken model. The adjuvanticity of Sargassum pallidum polysaccharides in Newcastle disease (ND, infectious bronchitis (IB and avian influenza (AI was investigated by examining the antibody titers and lymphocyte proliferation following immunization in chickens. The chickens were administrated combined ND, IB and AI inactivated vaccines containing SPP at 10, 30 and 50 mg/mL, using an oil adjuvant vaccine as a control. The ND, IB and AI antibody titers and the lymphocyte proliferation were enhanced at 30 mg/mL SPP. In conclusion, an appropriate dose of SPP may be a safe and efficacious immune stimulator candidate that is suitable for vaccines to produce early and persistent prophylaxis.

  13. Elisa evaluation of the levels of antibodies against Infectious Bronchitis Virus in laying hens using egg yolk as substrate

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    RH Rauber

    2004-06-01

    Full Text Available The present work was carried out to compare Infectious Bronchitis Virus (IBV antibody titers in serum and egg yolk samples from laying hens. Sixty paired blood and egg samples were collected from laying hens of two farms. Serum samples were frozen, while egg yolk samples were diluted (1:500 before freezing. Serum and yolk samples were tested for the presence of IBV antibodies by indirect ELISA (commercial kit and titers were compared by a correlation test (alpha=0.05. There was a high correlation (r=0.62 between the two kinds of samples, which means that titers of IBV antibodies in the egg yolk and in serum samples are quite the same. Considering that blood collection causes deep stress that leads to economic losses, and since eggs are collected daily on the farm, results reported here are of importance to poultry production.

  14. Serum levels of mannan-binding lectin in chickens prior to and during experimental infection with avian infectious bronchitis virus

    DEFF Research Database (Denmark)

    Juul-Madsen, H.R.; Munch, M.; Handberg, Kurt;

    2003-01-01

    increase of 24%, whereas the acute phase response in chickens challenged after 12 h of rest peaked after 3.1 d with an increase of 51%. The specific antibody titer against IBV was also tested, and a difference (P <0.0091) between the two experimental groups was found with peak titer values of 6,816 and 4...... or complement activation via MBL-associated serine proteases (MASP) -1 and -2. Thus, MBL plays a major role in the first-line innate defense against pathogens. We investigated the MBL concentrations in serum during experimental infectious bronchitis virus (IBV) infections in chickens. The results......,349. However, the highest value was found in chickens inoculated after 12 h of activity. Thus, an inverse relation exists between the MBL response and the IBV specific antibody response. The ability of MBL to activate the complement cascade was tested in a heterologous system by deposition of human C4 on the...

  15. Computed Tomography-based Subclassification of Chronic Obstructive Pulmonary Disease.

    Science.gov (United States)

    Dirksen, Asger; Wille, Mathilde M W

    2016-04-01

    Computed tomography (CT) is an obvious modality for subclassification of COPD. Traditionally, the pulmonary involvement of chronic obstructive pulmonary disease (COPD) in smokers is understood as a combination of deleterious effects of smoking on small airways (chronic bronchitis and small airways disease) and distal to the airways with destruction and loss of lung parenchyma (emphysema). However, segmentation of airways is still experimental; with contemporary high-resolution CT (HRCT) we can just see the "entrance" of small airways, and until now changes in airway morphology that have been observed in COPD are subtle. Furthermore, recent results indicate that emphysema may also be the essential pathophysiologic mechanism behind the airflow limitation of COPD. The definition of COPD excludes bronchiectasis as a symptomatic subtype of COPD, and CT findings in chronic bronchitis and exacerbations of COPD are rather unspecific. This leaves emphysema as the most obvious candidate for subclassification of COPD. Both chest radiologists and pulmonary physicians are quite familiar with the appearance of various patterns of emphysema on HRCT, such as centrilobular, panlobular, and paraseptal emphysema. However, it has not yet been possible to develop operational definitions of these patterns that can be used by computer software to automatically classify CT scans into distinct patterns. In conclusion, even though various emphysema patterns can be recognized visually, CT has not yet demonstrated a great potential for automated subclassification of COPD, and it is an open question whether it will ever be possible to achieve success equivalent to that obtained by HRCT in the area of interstitial lung diseases. PMID:27115944

  16. Chronic migraine.

    Science.gov (United States)

    Schwedt, Todd J

    2014-01-01

    Chronic migraine is a disabling neurologic condition that affects 2% of the general population. Patients with chronic migraine have headaches on at least 15 days a month, with at least eight days a month on which their headaches and associated symptoms meet diagnostic criteria for migraine. Chronic migraine places an enormous burden on patients owing to frequent headaches; hypersensitivity to visual, auditory, and olfactory stimuli; nausea; and vomiting. It also affects society through direct and indirect medical costs. Chronic migraine typically develops after a slow increase in headache frequency over months to years. Several factors are associated with an increased risk of transforming to chronic migraine. The diagnosis requires a carefully performed patient interview and neurologic examination, sometimes combined with additional diagnostic tests, to differentiate chronic migraine from secondary headache disorders and other primary chronic headaches of long duration. Treatment takes a multifaceted approach that may include risk factor modification, avoidance of migraine triggers, drug and non-drug based prophylaxis, and abortive migraine treatment, the frequency of which is limited to avoid drug overuse. This article provides an overview of current knowledge regarding chronic migraine, including epidemiology, risk factors for its development, pathophysiology, diagnosis, management, and guidelines. The future of chronic migraine treatment and research is also discussed. PMID:24662044

  17. [Mucolytics in acute and chronic respiratory tract disorders. II. Uses for treatment and antioxidant properties].

    Science.gov (United States)

    Kupczyk, Maciej; Kuna, Piotr

    2002-03-01

    In the first part of our editorial we reviewed the possible factors responsible for mucus hypersecretion in acute and chronic pulmonary diseases. The present paper presents the results of studies proving, that mucolytics are useful in adjunctive therapy of respiratory tract disorders. Mucolytic agents such as Ambroxol and N-acetylcysteine are able to alter the secretion of mucus and its physical properties which results in improvement of mucociliary clearance. Current evidence indicate, that these drugs are effective, especially in chronic obstructive pulmonary disease, asthma and acute bronchitis. They produce a modest improvement in symptom control and lung function. It has been demonstrated that there is a synergism between mucolytics and antibiotics in the treatment of exacerbation of chronic bronchitis. Moreover, they act as scavengers of reactive oxygen species. Ambroxol is able to inhibit mediator release involved in the pathogenesis of allergic inflammation. As mucolytics are cheap and well-tolerated they are beneficial in the therapy of patients suffering from respiratory tract disorders. PMID:12053601

  18. Patient-Specific Airway Wall Remodeling in Chronic Lung Disease.

    Science.gov (United States)

    Eskandari, Mona; Kuschner, Ware G; Kuhl, Ellen

    2015-10-01

    Chronic lung disease affects more than a quarter of the adult population; yet, the mechanics of the airways are poorly understood. The pathophysiology of chronic lung disease is commonly characterized by mucosal growth and smooth muscle contraction of the airways, which initiate an inward folding of the mucosal layer and progressive airflow obstruction. Since the degree of obstruction is closely correlated with the number of folds, mucosal folding has been extensively studied in idealized circular cross sections. However, airflow obstruction has never been studied in real airway geometries; the behavior of imperfect, non-cylindrical, continuously branching airways remains unknown. Here we model the effects of chronic lung disease using the nonlinear field theories of mechanics supplemented by the theory of finite growth. We perform finite element analysis of patient-specific Y-branch segments created from magnetic resonance images. We demonstrate that the mucosal folding pattern is insensitive to the specific airway geometry, but that it critically depends on the mucosal and submucosal stiffness, thickness, and loading mechanism. Our results suggests that patient-specific airway models with inherent geometric imperfections are more sensitive to obstruction than idealized circular models. Our models help to explain the pathophysiology of airway obstruction in chronic lung disease and hold promise to improve the diagnostics and treatment of asthma, bronchitis, chronic obstructive pulmonary disease, and respiratory failure. PMID:25821112

  19. Relationship between the use of inhaled steroids for chronic respiratory diseases and early outcomes in community-acquired pneumonia.

    Directory of Open Access Journals (Sweden)

    Jordi Almirall

    Full Text Available BACKGROUND: The role of inhaled steroids in patients with chronic respiratory diseases is a matter of debate due to the potential effect on the development and prognosis of community-acquired pneumonia (CAP. We assessed whether treatment with inhaled steroids in patients with chronic bronchitis, COPD or asthma and CAP may affect early outcome of the acute pneumonic episode. METHODS: Over 1-year period, all population-based cases of CAP in patients with chronic bronchitis, COPD or asthma were registered. Use of inhaled steroids were registered and patients were followed up to 30 days after diagnosis to assess severity of CAP and clinical course (hospital admission, ICU admission and mortality. RESULTS: Of 473 patients who fulfilled the selection criteria, inhaled steroids were regularly used by 109 (23%. In the overall sample, inhaled steroids were associated with a higher risk of hospitalization (OR=1.96, p = 0.002 in the bivariate analysis, but this effect disappeared after adjusting by other severity-related factors (adjusted OR=1.08, p=0.787. This effect on hospitalization also disappeared when considering only patients with asthma (OR=1.38, p=0.542, with COPD alone (OR=4.68, p=0.194, but a protective effect was observed in CB patients (OR=0.15, p=0.027. Inhaled steroids showed no association with ICU admission, days to clinical recovery and mortality in the overall sample and in any disease subgroup. CONCLUSIONS: Treatment with inhaled steroids is not a prognostic factor in COPD and asthmatic patients with CAP, but could prevent hospitalization for CAP in patients with clinical criteria of chronic bronchitis.

  20. Chronic inflammatory polyneuropathy

    Science.gov (United States)

    Polyneuropathy - chronic inflammatory; CIDP; Chronic inflammatory demyelinating polyneuropathy ... of the body equally. Chronic inflammatory demyelinating polyneuropathy (CIDP) is the most common chronic neuropathy caused by ...

  1. Chronic pancreatitis

    OpenAIRE

    Kocher, Hemant M; Froeling, Fieke EM

    2008-01-01

    Chronic pancreatitis is characterised by long-standing inflammation of the pancreas owing to a wide variety of causes, including recurrent acute attacks of pancreatitis. Chronic pancreatitis affects 3–9 people in 100,000; 70% of cases are alcohol-induced.

  2. Chronic pancreatitis

    OpenAIRE

    Kocher, Hemant M; Kadaba, Raghu

    2011-01-01

    Chronic pancreatitis is characterised by long-standing inflammation of the pancreas due to a wide variety of causes, including recurrent acute attacks of pancreatitis. Chronic pancreatitis affects between 3 and 9 people in 100,000; 70% of cases are alcohol-induced.

  3. Clinical Practice Guidelines for Severe Chronic Obstructive Pulmonary Disease. Guía de práctica clínica para el tratamiento de la enfermedad pulmonar obstructiva crónica grave.

    Directory of Open Access Journals (Sweden)

    Inti Santana Carballosa

    2009-03-01

    Full Text Available Clinical Practice Guidelines for Severe Chronic Obstructive Pulmonary Disease. This concept includes simple chronic bronchitis, asthmatic bronchitis, chronic obstructive bronchitis, and pulmonary emphysema; although this two last are the most commonly included. Risk factors, classification and treatment are commented, stressing the strategy of mechanical ventilation and the indications for mechanical invasive and no invasive ventilation. It includes assessment guidelines focused on the most important aspects to be accomplished.Guía de práctica clínica para el tratamiento de la enfermedad pulmonar obstructiva crónica grave. Término que encierra a la bronquitis crónica simple, bronquitis asmática, bronquitis obstructiva crónica y enfisema pulmonar; aunque son las dos últimas las más comúnmente incluidas. Se comentan los factores de riesgo, clasificación y tratamiento con énfasis en la estrategia de ventilación mecánica, así como las indicaciones de ventilación mecánica invasiva y no invasiva. Concluye con su guía de evaluación, enfocada en los aspectos más importantes a cumplir.

  4. Application of Irwin diagnostic procedures for chronic cough

    Directory of Open Access Journals (Sweden)

    Guo-fang FENG

    2011-07-01

    Full Text Available Objective To explore the advantages and disadvantages of the diagnostic procedures suggested by the Irwin group,and summarize the experiences in diagnosis and treatment,and to beter understand the etiology,diagnosis,differential diagnosis and treatment of chronic cough.Methods Data of 118 patients,who were finally diagnosed as chronic cough according to the diagnostic procedures suggested by Irwin group in the First Affiliated Hospital of General Hospital of PLA in 2009,were retrospectivety analyzed.Results With the Irwin diagnostic procedures of chronic cough,118 patients were diagnosed definitely.The final diagnostic rate reached 100%.The duration to reach the final diagnosis was 1 day to 30 days.Of the 118 patients with chronic cough,113 were cured(96%.32 cases(27.1% were caused by asthma and related diseases(allergic rhinitis,allergic pharyngitis,cough variant asthma and eosinophilic bronchitis;28 cases(23.7% were due to upper airway cough syndrome and related diseases(chronic rhinitis,sinusitis,pharyngeal bursitis,postnasal drip syndrome,chronic laryngitis,and vocal cord polyps;23 cases(19.5% due to gastroesophageal reflux disease;14 cases(11.9% due to lower respiratory tract infection and related diseases(endobronchial tuberculosis,pulmonary tuberculosis,endotracheal mucosal adenocarcinoma,lung cancer,bronchiectasis,and pulmonary fibrosis;10 cases(8.5% due to cardiac insafficiency;6 cases(5.1% due to administration of angiotensin-converting enzyme inhibitor(ACEI-like antihypertensive agents;3 cases(2.5% were psychogenic cough,and 2 cases(1.7% were induced by other causes.Conclusions The Irwin diagnosis of chronic cough is a comprehensive and thorough procedure,and it should be used with delibcration in clinic.The etiology of chronic cough is complicated,mainly including asthma and related diseases,sinusitis and upper airway cough syndrome,and gastroesophageal reflux disease.

  5. Proteomic analysis of chicken embryonic trachea and kidney tissues after infection in ovo by avian infectious bronchitis coronavirus

    OpenAIRE

    Kong Xiangang; Geng Heyuan; Shao Yuhao; Han Zongxi; Cao Zhongzan; Liu Shengwang

    2011-01-01

    Abstract Background Avian infectious bronchitis (IB) is one of the most serious diseases of economic importance in chickens; it is caused by the avian infectious coronavirus (IBV). Information remains limited about the comparative protein expression profiles of chicken embryonic tissues in response to IBV infection in ovo. In this study, we analyzed the changes of protein expression in trachea and kidney tissues from chicken embryos, following IBV infection in ovo, using two-dimensional gel e...

  6. Molecular detection of infectious bronchitis virus and it is relation with avian influenza virus (H9) and Mycoplasma gallisepticum from different geographical regions in Iraq

    OpenAIRE

    A.H. Al-Dabhawe; H.M. Kadhim; H.M. Samaka

    2013-01-01

    Infectious bronchitis virus (IBV), Avian influenza virus (AIV) and Mycoplasma gallisepticum (MG) have been recognized as the most important pathogens in poultry cause acute respiratory infection and serous economic problems in Iraq and many other countries all over the world. This study was conducted to investigate the distribution of these diseases in commercial chicken flocks in different geographical region in middle part of Iraq by using qPCR. Tracheal swabs and tissue specimens from trac...

  7. Chronic cholecystitis

    Science.gov (United States)

    ... foods may relieve symptoms in people. However, the benefit of a low-fat diet has not been proven. Alternative Names Cholecystitis - chronic Images Cholecystitis, CT scan Cholecystitis, cholangiogram Cholecystolithiasis Gallstones, cholangiogram Cholecystogram References Wang ...

  8. Chronic Pain

    Science.gov (United States)

    ... who have chronic pain may also have low self-esteem, depression, and anger. Causes & Risk Factors What causes ... as stretching and strengthening activities) and low-impact exercise (such as walking, swimming, or biking) can help ...

  9. Chronic Meningitis

    Science.gov (United States)

    ... School Lunch Lines FDA Cracks Down on Antibacterial Soaps Health Tip: Schedule a Back-to-School Dental ... the Professional Version Meningitis Introduction to Meningitis Acute Bacterial Meningitis Viral Meningitis Noninfectious Meningitis Recurrent Meningitis Chronic ...

  10. Chronic Pericarditis

    Science.gov (United States)

    ... Sugar Control Helps Fight Diabetic Eye Disease Are 'Workaholics' Prone to OCD, Anxiety? ALL NEWS > Resources First ... weeks after heart surgery) and is considered subacute. Causes Usually, the cause of chronic effusive pericarditis is ...

  11. On the Role of Mechanics in Chronic Lung Disease

    Directory of Open Access Journals (Sweden)

    Mona Eskandari

    2013-12-01

    Full Text Available Progressive airflow obstruction is a classical hallmark of chronic lung disease, affecting more than one fourth of the adult population. As the disease progresses, the inner layer of the airway wall grows, folds inwards, and narrows the lumen. The critical failure conditions for airway folding have been studied intensely for idealized circular cross-sections. However, the role of airway branching during this process is unknown. Here, we show that the geometry of the bronchial tree plays a crucial role in chronic airway obstruction and that critical failure conditions vary significantly along a branching airway segment. We perform systematic parametric studies for varying airway cross-sections using a computational model for mucosal thickening based on the theory of finite growth. Our simulations indicate that smaller airways are at a higher risk of narrowing than larger airways and that regions away from a branch narrow more drastically than regions close to a branch. These results agree with clinical observations and could help explain the underlying mechanisms of progressive airway obstruction. Understanding growth-induced instabilities in constrained geometries has immediate biomedical applications beyond asthma and chronic bronchitis in the diagnostics and treatment of chronic gastritis, obstructive sleep apnea and breast cancer.

  12. [Therapeutic training and sports in chronic diseases of the lung].

    Science.gov (United States)

    Podolsky, A; Haber, P

    1993-01-01

    Training is defined as systematic physical activity in order to improve the physical working capacity, which causes measurable morphological and functional changes in organs. Effects and the rules of applying aerobic endurance training in patients with chronic diseases of the lungs are dealt with. Training does not replace the normal medication, but is an additional therapeutic mean in order to regain physical working capacity, lost by chronic immobilization in the natural course of disease. Contraindications are acute diseases and exacerbations, but not a certain degree of the disease. Training does not improve the lung function, but the function of the other organs, the physical working capacity ist based on (circulation, musculature). This helps to use optimally the remaining reserves of lung function. Methods of aerobic endurance training are described, the definition of aims, performance diagnostic and the finding of the exact doses of training according to intensity, duration, frequency and the weekly netto training time. The training in different diseases of the lungs is discussed: In asthma bronchiale the prophylaxis of the exercise induced asthma and permitted and forbidden drugs for asthmatics according to the rules of international olympic committee. In chronic bronchitis with arterial hypoxemia, in restrictive lung diseases and in pulmonary hypertension. At last the way to prescribing training for patients with chronic pulmonary diseases is described as well as the advising of patients wishing to do sport by their own motivation or planning projects, for instance touristic ones, which require physical stress. PMID:8465532

  13. Pathogenesis Progression of Avian Infectious Bronchitis Virus%鸡传染性支气管炎病毒致病机理的研究进展

    Institute of Scientific and Technical Information of China (English)

    余娟; 刘兴友; 王玲丽

    2011-01-01

    鸡传染性支气管是由鸡传染性支气管炎病毒引起鸡的一种急性高度接触性呼吸道传染病,由于病毒血清型较多,易于发生变异而难以免疫预防,成为养鸡业发展的重大阻力.文章就该病毒的致病机理方面的研究情况做一综述,为防制鸡传染性支气管炎提供科学依据.%Infectious bronchitis virus (IBV) is causative pathogen of infectious bronchitis (IB) , an acute, highly contagious respiratory disease in chickens, the infectious bronchitis virus has many serotypes and is easy to mutate, which has caused the difficulty for the disease's prevention, and impeded the development of poultry industry. This paper reviewed etiology, pathogenesis of the IBV in order to provide evidence for IB prevention and control.

  14. Regional ventilation-perfusion ratio in chronic lung diseases measured with krypton-81m

    International Nuclear Information System (INIS)

    We measured regional ventilation-perfusion ratio (V radical/Q radical) by continuous inhalation of Kr-81 m and also continuous injection of Kr-81 m. The V radical/Q radical distribution can be divided four types. Type I is the normal pattern and V radical/Q radical value is the highest at apex. Type II has the highest V radical/Q radical value not at the apex but one third lower from the apex and the V radical/Q radical value gradually decreases towards the base. In type III V radical/Q radical has no gradient from the apex to the base. In type IV V radical/Q radical of the base higher than that of the apex. Most pulmonary emphysema show type I, most chronic bronchitis show type II and many interstitial pneumonia denote type IV. The ratio between the area in which the V radical/Q radical value was lower than 0.75, and the area of total lung (% 0.75) correlated with PaO2 (r = 0.59 p < 0.01). Coefficiency of variation (COV) of V radical/Q radical was larger in pulmonary emphysema and in interstitial pneumonia than in normal lung and COV of V radical/Q radical was the largest in chronic bronchitis. (author)

  15. Proteomic analysis of chicken embryonic trachea and kidney tissues after infection in ovo by avian infectious bronchitis coronavirus

    Directory of Open Access Journals (Sweden)

    Kong Xiangang

    2011-03-01

    Full Text Available Abstract Background Avian infectious bronchitis (IB is one of the most serious diseases of economic importance in chickens; it is caused by the avian infectious coronavirus (IBV. Information remains limited about the comparative protein expression profiles of chicken embryonic tissues in response to IBV infection in ovo. In this study, we analyzed the changes of protein expression in trachea and kidney tissues from chicken embryos, following IBV infection in ovo, using two-dimensional gel electrophoresis (2-DE coupled with matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry (MALDI-TOF-TOF MS. Results 17 differentially expressed proteins from tracheal tissues and 19 differentially expressed proteins from kidney tissues were identified. These proteins mostly related to the cytoskeleton, binding of calcium ions, the stress response, anti-oxidative, and macromolecular metabolism. Some of these altered proteins were confirmed further at the mRNA level using real-time RT-PCR. Moreover, western blotting analysis further confirmed the changes of annexin A5 and HSPB1 during IBV infection. Conclusions To the best of our knowledge, we have performed the first analysis of the proteomic changes in chicken embryonic trachea and kidney tissues during IBV infection in ovo. The data obtained should facilitate a better understanding of the pathogenesis of IBV infection.

  16. Cloning and Sequencing of S Gene of Novel Variant of Infectious Bronchitis Virus ZJ971 Isolates in China

    Institute of Scientific and Technical Information of China (English)

    ZHOU Ji-yong; CHENG Li-qin; SHEN Xing-yan; DING Hong-mei; WU Jian-xiang

    2002-01-01

    A novel proventriculopathogic variant (isolate ZJ971) of infectious bronchitis virus (IBV) was identified from enlarged proeventriculus of the sick chickens in the study. The S gene cDNA segment with 3.6 kb in length was amplified by RT-PCR with special primers from the ZJ971 viral isolate of (IBV) and cloned into plasmid pBluescript SK( + ). The recombinants containing S gene of IBV-ZJ971 isotate were identified by digestion of restriction enzyme EcoRI, BamHI and PCR amplification. The cloned S gene from isolate IBVZJ971 was composed of 3492 bp in length encoding for a polypeptide of 1080 amino acids. Comparing the nucleotide of S gene of IBV isolate ZJ971 with that of reported IBV strains Beaudette, M41, Ark99 and CuT2,the homology was 97.3%, 97.5%, 88.6% and 85.6%, respectively; and the homology of the deduced amino acids of S protein of IBV isolate ZJ971 was 96%, 96.3%, 86.1% and 83.1% respectively; especially, the mutation of 3241st nucleotide of S gene of IBV isolate ZJ971 from G to T resulted in the translating termination of S protein at 3240th nucleotide site.

  17. In vitro and in ovo expression of chicken gamma interferon by a defective RNA of avian coronavirus infectious bronchitis virus.

    Science.gov (United States)

    Hackney, Karen; Cavanagh, Dave; Kaiser, Pete; Britton, Paul

    2003-05-01

    Coronavirus defective RNAs (D-RNAs) have been used for site-directed mutagenesis of coronavirus genomes and for expression of heterologous genes. D-RNA CD-61 derived from the avian coronavirus infectious bronchitis virus (IBV) was used as an RNA vector for the expression of chicken gamma interferon (chIFN-gamma). D-RNAs expressing chIFN-gamma were shown to be capable of rescue, replication, and packaging into virions in a helper virus-dependent system following electroporation of in vitro-derived T7 RNA transcripts into IBV-infected cells. Secreted chIFN-gamma, under the control of an IBV transcription-associated sequence derived from gene 5 of the Beaudette strain, was expressed from two different positions within CD-61 and shown to be biologically active. In addition, following infection of 10-day-old chicken embryos with IBV containing D-RNAs expressing chIFN-gamma, the allantoic fluid was shown to contain biologically active chIFN-gamma, demonstrating that IBV D-RNAs can express heterologous genes in vivo. PMID:12719562

  18. The virion N protein of infectious bronchitis virus is more phosphorylated than the N protein from infected cell lysates

    International Nuclear Information System (INIS)

    Because phosphorylation of the infectious bronchitis virus (IBV) nucleocapsid protein (N) may regulate its multiple roles in viral replication, the dynamics of N phosphorylation were examined. 32P-orthophosphate labeling and Western blot analyses confirmed that N was the only viral protein that was phosphorylated. Pulse labeling with 32P-orthophosphate indicated that the IBV N protein was phosphorylated in the virion, as well as at all times during infection in either chicken embryo kidney cells or Vero cells. Pulse-chase analyses followed by immunoprecipitation of IBV N proteins using rabbit anti-IBV N polyclonal antibody demonstrated that the phosphate on the N protein was stable for at least 1 h. Simultaneous labeling with 32P-orthophosphate and 3H-leucine identified a 3.5-fold increase in the 32P:3H counts per minute (cpm) ratio of N in the virion as compared to the 32P:3H cpm ratio of N in the cell lysates from chicken embryo kidney cells, whereas in Vero cells the 32P:3H cpm ratio of N from the virion was 10.5-fold greater than the 32P:3H cpm ratio of N from the cell lysates. These studies are consistent with the phosphorylation of the IBV N playing a role in assembly or maturation of the viral particle

  19. Interactive mechanism between avian infectious bronchitis S1 protein T cell peptide and avian MHC I molecule.

    Science.gov (United States)

    Zhu, Feng-Zhu; Lu, Mei; Huang, Qing-Hua; Huang, Yan-Yan; Yang, Shao-Hua; Cui, Yan-Shun; Liu, Chang; Tan, Liugang; Kong, Zhengjie; Xu, Chuan-Tian

    2016-04-01

    This study aims to construct a 3D structure of the avian major histocompatibility complex (MHC)-β2M complex through homology modelling technology, perform molecular docking of the predicted infectious bronchitis virus (IBV) S1 protein potential epitope peptide Sp6 (NQFYIKLT) and the avian MHC-β2M complex, and demonstrate the interactive mechanism between Sp6 and MHC using molecular dynamical simulations. The peptide Sp6 and the non-related peptide NP89-97 (PKKTGGPIY) were used to stimulate in vitro recombinant plasmid (pCAGGS-S1) avian splenic lymphocytes. Flow cytometric results show that CD8(+) T lymphocytes reproduce stimulated by the Sp6 and the nonrelated peptide proliferate by 34.8% and 2.6%, respectively. Meanwhile, fluorescent quantitative PCR results show that the secretion of IFN-γ in avian splenic lymphocytes increases after Sp6 stimulation. These data suggest that Sp6 can induce the activated avian lymphocytes in vitro to produce CTL, which is the CTL epitope in IBV S1. PMID:26876645

  20. Chronic myelogenous leukemia (CML)

    Science.gov (United States)

    CML; Chronic myeloid leukemia; Chronic granulocytic leukemia; Leukemia - chronic granulocytic ... nuclear disaster. It takes many years to develop leukemia from radiation exposure. Most people treated for cancer ...

  1. Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Patel, Bipen D; Coxson, Harvey O; Pillai, Sreekumar G;

    2008-01-01

    RATIONALE: It is unclear whether airway wall thickening and emphysema make independent contributions to airflow limitation in chronic obstructive pulmonary disease (COPD) and whether these phenotypes cluster within families. OBJECTIVES: To determine whether airway wall thickening and emphysema (1...... severity of airway wall thickening and emphysema. MEASUREMENTS AND MAIN RESULTS: A total of 3,096 individuals were recruited to the study, of whom 1,159 (519 probands and 640 siblings) had technically adequate high-resolution computed tomography scans without significant non-COPD-related thoracic disease....... Airway wall thickness correlated with pack-years smoked (P < or = 0.001) and symptoms of chronic bronchitis (P < 0.001). FEV(1) (expressed as % predicted) was independently associated with airway wall thickness at a lumen perimeter of 10 mm (P = 0.0001) and 20 mm (P = 0.0013) and emphysema at -950...

  2. Morphological findings in lungs of the horses with chronic obstructive pulmonary disease (COPD

    Directory of Open Access Journals (Sweden)

    Marinković Darko

    2007-01-01

    Full Text Available The frequency and characteristics of chronic obstructive pulmonary disease (COPD based on morphological and cytological changes in equine lungs were studied in this paper. Lungs obtained from 51 horses of different age and sex were examined grossly and tissue samples were collected for pathohistological examination. Cytological examination was done on impression smears from the tracheal bifurcation. Pathohistological preparations were stained with hematoxylin eosin (HE, toluidine blue (TB, Giemsa staining, PAS staining and Pearls reaction for iron detection. The peroxidase anti-peroxidase technique was used to demonstrate CD3+ (T lymphocytes and CD79+ (B lymphocytes. Tracheal bifurcation cytology impression smears were stained with hematoxylin eosin (HE, Giemsa staining and PAS staining. Pulmonary emphysema and lack of pulmonary collapse were the most common gross lesions whereas alveolar emphysema was described in 70.59% of all examined horses, more frequently in the distensive form (54.90% and less frequently in the destructive form (15.69%. Pathohistological chronic bronchitis/bronchiolitis, with characteristic changes in the lumen, mucosa, submucosa and smooth muscle layer was described in all examined horses. Increased immunoreactivity was described in the lungs. The most common lesions seen on cytology impression smears from the tracheal bifurcation were thick, viscous, PAS positive mucus which forms Curschmann's spirals. The dominant cell population consisted of desquamated airway epithelial cells, as well as eosinophils, neutrophils, mast cells, erythrocytes and alveolar macrophages. Primary pulmonary pathogens as well as potential contaminants and secundary infection agens were isolated bacteriologically from lung samples. All the above-mentioned findings correlate pointing to the fact that chronic bronchitis/bronchiolitis represents the basic substrate of chronic obstructive pulmonary disease (COPD which has a combined inflammatory and

  3. Low back pain - chronic

    Science.gov (United States)

    Nonspecific back pain; Backache - chronic; Lumbar pain - chronic; Pain - back - chronic; Chronic back pain - low ... Low back pain is common. Almost everyone has back pain at some time in their life. Often, the exact cause of ...

  4. Chronic Pelvic Pain

    Science.gov (United States)

    ... Events Advocacy For Patients About ACOG Chronic Pelvic Pain Home For Patients Search FAQs Chronic Pelvic Pain ... Pain FAQ099, August 2011 PDF Format Chronic Pelvic Pain Gynecologic Problems What is chronic pelvic pain? What ...

  5. Employees with Chronic Pain

    Science.gov (United States)

    ... Home | Accommodation and Compliance Series: Employees with Chronic Pain By Beth Loy, Ph.D. Preface Introduction Information ... at http://AskJAN.org/soar. Information about Chronic Pain How prevalent is chronic pain? Chronic pain has ...

  6. Efficacy of Add-on Montelukast in Nonasthmatic Eosinophilic Bronchitis: The Additive Effect on Airway Inflammation, Cough and Life Quality

    Institute of Scientific and Technical Information of China (English)

    Wuping Bao; Ping Liu; Zhongmin Qiu; Li Yu; Jingqing Hang; Xiaohua Gao; Xin Zhou

    2015-01-01

    Background:The efficacy of montelukast (MONT),a cysteinyl leukotriene receptor antagonist,in nonasthmatic eosinophilic bronchitis (NAEB),especially its influence on cough associated life quality is still indefinite.We evaluated the efficacy of MONT combined with budesonide (BUD) as compared to BUD monotherapy in improving life quality,suppressing airway eosinophilia and cough remission in NAEB.Methods:A prospective,open-labeled,multicenter,randomized controlled trial was conducted.Patients with NAEB (aged 18-75 years) were randomized to inhaled BUD (200 μg,bid) or BUD plus oral MONT (10 μg,qn) for 4 weeks.Leicester cough questionnaire (LCQ) life quality scores,cough visual analog scale (CVAS) scores,eosinophil differential ratio (Eos),and eosinophil cationic protein (ECP) in induced sputum were monitored and compared.Results:The control and MONT groups contained 33 and 32 patients,respectively,with similar baseline characteristics.Significant with-in group improvement in CVAS,LCQ scores,Eos,and ECP was observed in both groups during treatment.After 2-week treatment,add-on treatment of MONT was significantly more effective than BUD monotherapy for CVAS decrease and LCQ scores improvement (both P < 0.05).Similar results were seen at 4-week assessment (both P < 0.05).4-week add-on therapy of MONT also resulted in a higher percentage of patients with normal sputum Eos (<2.5%) and greater decrease of ECP (both P < 0.05).Conclusions:MONT combined with BUD was demonstrated cooperative effects in improvement of life quality,suppression ofeosinophilic inflammation,and cough remission in patients with NAEB.

  7. Increased expression of Interleukin-6 related to nephritis in chickens challenged with an Avian infectious bronchitis virus variant

    Directory of Open Access Journals (Sweden)

    Filipe S. Fernando

    2015-03-01

    Full Text Available A Brazilian field isolate (IBV/Brazil/PR05 of avian infectious bronchitis virus (IBV, associated with development of nephritis in chickens, was previously genotyped as IBV variant after S1 gene sequencing. The aim of this study was to evaluate the levels of IL-6 in kidneys and trachea of birds vaccinated and challenged with IBV/Brazil/PR05 strain, correlating these results with scores of microscopic lesions, specific IBV antigen detection and viral load. The up-regulation of IL-6 and the increased levels of viral load on renal and tracheal samples were significantly correlated with scores of microscopic lesions. Reduced levels of viral load were detected in kidneys of birds previously vaccinated and challenged, compared to non-vaccinated challenged group, although markedly microscopic lesions were observed for both groups. The expression of IL-6, present both in the kidney and in the tracheas, was dependent on the load of the virus present in the tissue, and the development of lesions was related with IL-6 present in the tissues. These data suggest that variant IBV/Brazil/PR05 can induce the expression of proinflammatory cytokines in a manner correlated with viral load and increased IL-6 is involved in the tissue with the influx of inflammatory cells and subsequent nephritis. This may contribute with a model to the development of immunosuppressive agents of IL-6 to prevent acute inflammatory processes against infection with IBV and perhaps other coronaviruses, as well as contribute to the understanding of the immunopathogenesis of IBV nephropatogenic strains.

  8. Differential detection of turkey coronavirus, infectious bronchitis virus, and bovine coronavirus by a multiplex polymerase chain reaction.

    Science.gov (United States)

    Loa, C C; Lin, T L; Wu, C C; Bryan, T A; Hooper, T A; Schrader, D L

    2006-01-01

    The objective of the present study was to develop a multiplex polymerase chain reaction (PCR) method for differential detection of turkey coronavirus (TCoV), infectious bronchitis coronavirus (IBV), and bovine coronavirus (BCoV). Primers were designed from conserved or variable regions of nucleocapsid (N) or spike (S) protein gene among TCoV, IBV, and BCoV and used in the same PCR reaction. Reverse transcription followed by the PCR reaction was used to amplify a portion of N or S gene of the corresponding coronaviruses. The PCR products were detected on agarose gel stained with ethidium bromide. Two PCR products, a 356-bp band corresponding to N gene and a 727-bp band corresponding to S gene, were obtained for TCoV isolates. In contrast, one PCR product of 356 bp corresponding to a fragment of N gene was obtained for IBV strains and one PCR product of 568 bp corresponding to a fragment of S gene was obtained for BCoV. There were no PCR products with the same primers for Newcastle disease virus, Marek's disease virus, turkey pox virus, pigeon pox virus, fowl pox virus, reovirus, infectious bursal disease virus, enterovirus, astrovirus, Salmonella enterica, Escherichia coli, and Mycoplasma gallisepticum. Performance of the assay with serially diluted RNA demonstrated that the multiplex PCR could detect 4.8x10(-3) microg of TCoV RNA, 4.6x10(-4) microg of IBV RNA, and 8.0x10(-2) microg of BCoV RNA. These results indicated that the multiplex PCR as established in the present study is a rapid, sensitive, and specific method for differential detection of TCoV, IBV, and BCoV in a single PCR reaction. PMID:16137773

  9. Efficacy of Add-on Montelukast in Nonasthmatic Eosinophilic Bronchitis: The Additive Effect on Airway Inflammation, Cough and Life Quality

    Directory of Open Access Journals (Sweden)

    Wuping Bao

    2015-01-01

    Full Text Available Background: The efficacy of montelukast (MONT, a cysteinyl leukotriene receptor antagonist, in nonasthmatic eosinophilic bronchitis (NAEB, especially its influence on cough associated life quality is still indefinite. We evaluated the efficacy of MONT combined with budesonide (BUD as compared to BUD monotherapy in improving life quality, suppressing airway eosinophilia and cough remission in NAEB. Methods: A prospective, open-labeled, multicenter, randomized controlled trial was conducted. Patients with NAEB (aged 18-75 years were randomized to inhaled BUD (200 μg, bid or BUD plus oral MONT (10 μg, qn for 4 weeks. Leicester cough questionnaire (LCQ life quality scores, cough visual analog scale (CVAS scores, eosinophil differential ratio (Eos, and eosinophil cationic protein (ECP in induced sputum were monitored and compared. Results: The control and MONT groups contained 33 and 32 patients, respectively, with similar baseline characteristics. Significant with-in group improvement in CVAS, LCQ scores, Eos, and ECP was observed in both groups during treatment. After 2-week treatment, add-on treatment of MONT was significantly more effective than BUD monotherapy for CVAS decrease and LCQ scores improvement (both P < 0.05. Similar results were seen at 4-week assessment (both P < 0.05. 4-week add-on therapy of MONT also resulted in a higher percentage of patients with normal sputum Eos (<2.5% and greater decrease of ECP (both P < 0.05. Conclusions: MONT combined with BUD was demonstrated cooperative effects in improvement of life quality, suppression of eosinophilic inflammation, and cough remission in patients with NAEB.

  10. Bronquite plástica em criança com talassemia alfa Plastic bronchitis in a child with thalassemia alpha

    Directory of Open Access Journals (Sweden)

    Tiago N. Veras

    2005-12-01

    Full Text Available OBJETIVO: A bronquite plástica é uma doença infreqüente na criança, sendo caracterizada por moldes ou cilindros mucofibrinosos na árvore traqueobrônquica. Faz parte do diagnóstico diferencial de crianças com insuficiência respiratória de início agudo, e o tratamento precoce é importante para a resolução do quadro. O objetivo deste relato é descrever um caso de bronquite plástica tratado com sucesso por endoscopia, em paciente portador de talassemia alfa. DESCRIÇÃO: Criança do sexo masculino, 3 anos de idade, sem antecedentes mórbidos significativos, apresentou quadro de insuficiência respiratória aguda, com achados radiológicos de atelectasia pulmonar sugestivos de aspiração de corpo estranho. Não havia sintomas respiratórios ou antecedentes de alergia ou infecções respiratórias de repetição. A realização de broncoscopia flexível, complementada por endoscopia rígida e exame anatomopatológico, evidenciou a presença de bronquite plástica. Após a realização da endoscopia, a criança evoluiu satisfatoriamente, com curva térmica afebril e extubação em 72 horas. Foram utilizadas medicações sintomáticas, sem necessidade de antimicrobianos. Dez dias após a alta, a radiografia de tórax encontrava-se normal. A talassemia alfa foi diagnosticada através da eletroforese de hemoglobina. COMENTÁRIOS: A importância clínica da bronquite plástica reside no fato de apresentar um quadro semelhante ao de outras doenças mais prevalentes, como a aspiração de corpo estranho e a asma brônquica. A suspeita do quadro recomenda a realização de endoscopia para diagnóstico e tratamento. É reconhecida a ocorrência de bronquite plástica em crianças com fibrose cística, pós-operatório de cirurgia cardíaca e anemia falciforme. No presente artigo, foi observada uma associação com talassemia alfa.OBJECTIVE: Plastic bronchitis is an unusual condition in children, associated with formation of mucofibrinous

  11. Chronic Respiratory Apparatus Diseases by Dog-day Moxibustion%三伏灸治疗慢性呼吸道疾病的疗效观察

    Institute of Scientific and Technical Information of China (English)

    艾宙; 刘媛媛; 奚玉风; 张倩如; 邹婷; 陈瑞; 方焕奎

    2011-01-01

    目的:观察慢性呼吸道疾病如慢性咽炎、过敏性鼻炎、慢性单纯性鼻炎、慢性支气管炎(缓解期)、支气管哮喘(缓解期)应用三伏灸的疗效,探讨三伏灸疗法对多种常见慢性呼吸道疾病的优势病种.方法:在每年确定的三伏天时间内,将"天灸膏"药粉配适量蜂蜜和新鲜姜汁调和,制成软膏状,将药物敷贴固定在相关穴位.结果:慢性单纯性鼻炎疗程越长则疗效越好;过敏性鼻炎、慢性咽炎见效稍缓;慢性支气管炎和哮喘则起效较快、疗效相对稳定.%Objective: To observe the effects of natural moxibustion in dogdays on chronic respiratory apparatus disease, such as chronic pharyngitis, allergic rhnitis, chronic simple rhinitis, chronic bronchitis (in remission), bronchial asthma( in remssion).Find out the advantage effect of these chronic respiratory apparatus diseases.Methods: In the specified dog days each year, stick ointmeat of natural moxibustion which is mixed with suitable amount of honey and fresh ginger on the related points.Results:The effect on chronic simple rhinitis is connected with the time of natural moxibustion in dogdays.Conclusion :The effects on allergic coryza and chronic pharyngitis are slow.The effects on chronic bronchitis and Asthma are much more obvious than others.

  12. Effectiveness of anti-inflammatory treatment versus antibiotic therapy and placebo for patients with non-complicated acute bronchitis with purulent sputum. The BAAP Study protocol

    Directory of Open Access Journals (Sweden)

    Fernández Yvonne

    2011-06-01

    Full Text Available Abstract Background Acute bronchitis is one of the most prevalent respiratory infections in primary care, and in more than 90% of the cases antibiotics are prescribed, mainly when purulent expectoration is present. However, this process is usually viral in origin and the benefits of antibiotic treatment are marginal. On the other hand, in recent years bronchitis has been considered more as an inflammatory than an infectious process. Thus, the aim of this study is to evaluate the clinical effectiveness of a schedule of an oral anti-inflammatory compared with an antibiotic regimen and another group assigned to receive a placebo. Methods and design A total of 420 patients from 15 to 70 years of age with no associated comorbidity, presenting respiratory tract infection of at least one week of evolution, with cough as the predominant symptom, the presence of purulent expectoration and at least one other symptom of the respiratory tract (dyspnoea, wheezing, chest discomfort or pain, with no alternative explanation such as pneumonia, will be included in a prospective, randomised and controlled, clinical trial with placebo. The patients will be randomised to receive one of three treatments: ibuprofen, amoxycillin and clavulanic acid or placebo for 10 days. The main outcome measure is the number of days with frequent cough defined by the symptom diary with a score of 1 or more. Discussion This trial is designed to evaluate the number of days with frequent cough with anti-inflammatory treatment compared with antimicrobial treatment and placebo in previously healthy patients with a clinical picture of acute bronchitis and purulent expectoration. It is hypothesized that anti-inflammatory treatment is more effective than antibiotic treatment to reduce cough, which is the most disturbing symptom for patients with this infection. Trial registration ISRCTN07852892

  13. Chronic coughing

    International Nuclear Information System (INIS)

    Chronic coughing was acknowledged to result from pathological state of the respiratory organs. Cardiac diseases could be accompanied by coughing as well. It was recommended to perform x-ray examinations, including biomedical radiography of the chest, computerized tomography, scintiscanning with 67Ga-citrate, bronchi examination in order to exclude heart disease. The complex examination permitted to detect localization and type of the changes in the lungs and mediastinum, to distinguish benign tumor from malignant one

  14. Analysis of allergen detection results in children with acute bronchitis%急性支气管炎患儿血清过敏原检测分析

    Institute of Scientific and Technical Information of China (English)

    朱晓莉; 陶春妃

    2016-01-01

    Objective:To detect and analyze serum allergen of 87 children with acute bronchitis. Methods:87 patients with acute bronchitis were selected for serum allergen detection, and compared with the control group of 87 normal subjects ( no special al-lergic history). Results:For the 87 cases of children with acute bronchitis, the serum allergen test positive rate was 62. 07% (54/87);while for the control group, the serum specific allergen test positive rate was 17. 24% (15/87);and the difference was statisti-cally significant (P0. 05). The most common inhaled allergen was house dust mites/dust mites, accounting for 25. 29%, while the common ingested al-lergens were cod/lobster/scallops, crab, peanut, the proportion of 13. 79%, 18. 39% and 12. 64%, separately. Conclusions: For the children with acute bronchitis, the serum allergen detection has a higher positive detection rate, and is significant for the treatment and prevention.%目的::检测分析儿童急性支气管炎的血清过敏原。方法:将87例临床诊断为急性支气管炎患儿设为急性支气管炎组,选择87例同期健康儿童作为对照组,检测比较两组研究对象的血清过敏原。结果:急性支气管炎组患儿的血清过敏原检测阳性率为62.07%(54/87),与对照组儿童的血清特异性过敏原阳性率为17.24%(15/87)比,差异有统计学意义(P0.05);吸入性过敏原阳性率较高的为屋尘螨/粉尘螨,占比25.29%;食入性过敏原阳性率较高的是鳕鱼/龙虾/扇贝、螃蟹、花生,占比分别为13.79%、18.39%、12.64%。结论:儿童急性支气管炎血清过敏原检测具有较高的阳性检出率,对治疗和预防具有重要意义。

  15. FISHBURN’S METHOD: A METHOD OF DRUGS CLINICAL EFFICIENCY EVALUATION (ON THE EXAMPLE OF ANTIBIOTICS, APPLIED FOR THE TREATMENT OF ACUTE AND RECIDIVOUS OBSTRUCTIVE BRONCHITIS OF CHILDREN

    Directory of Open Access Journals (Sweden)

    O. V. Zhukova

    2015-01-01

    Full Text Available We have studied a structure of a therapy with antibiotics which is applied for patients with acute and recidivous obstructive bronchitis. We have determined a clinical efficiency of each antibiotic used. We have presented a methodology of weight coefficients calculation efficiency by the Fishburn’s method. We have also presented a method for antibiotics distribution by the levels of clinical efficiency – high, medium, and low.

  16. Intake of high fructose corn syrup sweetened soft drinks is associated with prevalent chronic bronchitis in U.S. Adults, ages 20–55 y

    OpenAIRE

    DeChristopher, Luanne Robalo; URIBARRI, JAIME; Tucker, Katherine L.

    2015-01-01

    Background High fructose corn syrup (HFCS) sweetened soft drink intake has been linked with asthma in US high-schoolers. Intake of beverages with excess free fructose (EFF), including apple juice, and HFCS sweetened fruit drinks and soft drinks, has been associated with asthma in children. One hypothesis for this association is that underlying fructose malabsorption and fructose reactivity in the GI may contribute to in situ formation of enFruAGEs. EnFruAGEs may be an overlooked source of adv...

  17. Chronic Insomnia

    OpenAIRE

    Buysse, Daniel J.

    2008-01-01

    Ms. F, a 42-year-old divorced woman, presents for evaluation of chronic insomnia. She complains of difficulty falling asleep, often 30 minutes or longer, and difficulty maintaining sleep during the night, with frequent awakenings that often last 30 minutes or longer. These symptoms occur nearly every night, with only one or two “good” nights per month. She typically goes to bed around 10:00 p.m. to give herself adequate time for sleep, and she gets out of bed around 7:00 a.m. on work days and...

  18. Evolutionary and bioinformatic analysis of the spike glycoprotein gene of H120 vaccine strain protectotype of infectious bronchitis virus from India.

    Science.gov (United States)

    Kamble, Nitin Machindra; Pillai, Aravind S; Gaikwad, Satish S; Shukla, Sanjeev Kumar; Khulape, Sagar Aashok; Dey, Sohini; Mohan, C Madhan

    2016-01-01

    The infectious bronchitis virus is a causative agent of avian infectious bronchitis (AIB), and is is an important disease that produces severe economic losses to the poultry industry worldwide. Recent AIB outbreaks in India have been associated with poor growth in broilers, drop in egg production, and thin egg shells in layers. The complete spike gene of Indian AIB vaccine strain was amplified and sequenced using a conventional reverse transcription polymerase chain reaction and is submitted to the GenBank (accession no KF188436). Phylogenetic analysis revealed that the vaccine strain currently used belongs to H120 genotype, an attenuated strain of Massachusetts (Mass) serotype. Nucleotide and amino acid sequence comparisons have shown that the reported spike gene from Indian isolates have 71.8%-99% and 71.4%-96.9% genetic similarity with the sequenced H120 strain. The study identifies live attenuated IBV vaccine strain, which is routinely used for vaccination, for the first time. Based on nucleotide and amino acid relatedness studies of the vaccine strain with reported IBV sequences from India, it is shown that the current vaccine strain is efficient in controlling the IBV infection. Continuous monitoring of IBV outbreaks by sequencing for genotyping and in vivo cross protection studies for serotyping is not only important for epidemiological investigation but also for evaluation of efficacy of the current vaccine. PMID:25311758

  19. Valuing the Economic Costs of Allergic Rhinitis, Acute Bronchitis, and Asthma from Exposure to Indoor Dampness and Mold in the US.

    Science.gov (United States)

    Mudarri, David H

    2016-01-01

    Two foundational methods for estimating the total economic burden of disease are cost of illness (COI) and willingness to pay (WTP). WTP measures the full cost to society, but WTP estimates are difficult to compute and rarely available. COI methods are more often used but less likely to reflect full costs. This paper attempts to estimate the full economic cost (2014$) of illnesses resulting from exposure to dampness and mold using COI methods and WTP where the data is available. A limited sensitivity analysis of alternative methods and assumptions demonstrates a wide potential range of estimates. In the final estimates, the total annual cost to society attributable to dampness and mold is estimated to be $3.7 (2.3-4.7) billion for allergic rhinitis, $1.9 (1.1-2.3) billion for acute bronchitis, $15.1 (9.4-20.6) billion for asthma morbidity, and $1.7 (0.4-4.5) billion for asthma mortality. The corresponding costs from all causes, not limited to dampness and mold, using the same approach would be $24.8 billion for allergic rhinitis, $13.5 billion for acute bronchitis, $94.5 billion for asthma morbidity, and $10.8 billion for asthma mortality. PMID:27313630

  20. Valuing the Economic Costs of Allergic Rhinitis, Acute Bronchitis, and Asthma from Exposure to Indoor Dampness and Mold in the US

    Directory of Open Access Journals (Sweden)

    David H. Mudarri

    2016-01-01

    Full Text Available Two foundational methods for estimating the total economic burden of disease are cost of illness (COI and willingness to pay (WTP. WTP measures the full cost to society, but WTP estimates are difficult to compute and rarely available. COI methods are more often used but less likely to reflect full costs. This paper attempts to estimate the full economic cost (2014$ of illnesses resulting from exposure to dampness and mold using COI methods and WTP where the data is available. A limited sensitivity analysis of alternative methods and assumptions demonstrates a wide potential range of estimates. In the final estimates, the total annual cost to society attributable to dampness and mold is estimated to be $3.7 (2.3–4.7 billion for allergic rhinitis, $1.9 (1.1–2.3 billion for acute bronchitis, $15.1 (9.4–20.6 billion for asthma morbidity, and $1.7 (0.4–4.5 billion for asthma mortality. The corresponding costs from all causes, not limited to dampness and mold, using the same approach would be $24.8 billion for allergic rhinitis, $13.5 billion for acute bronchitis, $94.5 billion for asthma morbidity, and $10.8 billion for asthma mortality.

  1. Bronquite infecciosa das galinhas: conhecimentos atuais, cepas e vacinas no Brasil Infectious bronchitis of chickens: current knowledge, strains and vaccines in Brazil

    Directory of Open Access Journals (Sweden)

    Juliana Figueiredo Pitangui Mendonça

    2009-11-01

    Full Text Available A bronquite infecciosa das galinhas (IB é uma doença viral aguda e altamente contagiosa que provoca grandes perdas econômicas à indústria avícola em todo o mundo. Considerando que surtos têm ocorrido no Brasil com emergência de novas variantes de IBV, desafiando as estratégias de vacinação atuais, este trabalho objetiva revisar os conhecimentos sobre IB e IBV, a sua distribuição, as cepas e as vacinas utilizadas no Brasil.Infectious bronchitis (IB is an acute, highly contagious disease of chickens, caused by infectious bronchitis virus (IBV, which results in great economic losses to the poultry industry worldwide, despite the routine use of vaccines. Several outbreaks do occur periodically in densely populated poultry regions in Brazil and there are constant emergence of new variants. The aim of this paper is to review the current knowledge about IBV and IB, the distribution, strains and vaccines in Brazil.

  2. Protection conferred by a recombinant Marek’s disease virus that expresses the spike protein from infectious bronchitis virus in specific pathogen-free chicken

    Directory of Open Access Journals (Sweden)

    Zhang Xiaorong

    2012-05-01

    Full Text Available Abstract Background In many countries, the predominant field isolates of infectious bronchitis virus (IBV have been classified as QX-like strains since 1996. However, no commercial vaccines that are specific for this type of IBV are currently available. Therefore, there is an urgent need to develop novel vaccines that prevent QX-like IBV infection. Results A recombinant Marek’s disease virus (MDV, rMDV-S1, that expresses the S1 subunit of the spike (S protein from the QX-like infectious bronchitis virus (IBV was constructed by inserting the IBV S1 gene into the genome of the CVI988/Rispens strain of MDV. Specific pathogen-free (SPF chickens that were vaccinated with rMDV-S1 were protected when challenged with the QX-like IBV. They were observed to have mild clinical signs of disease, a short virus-shedding period and low mortality. Additionally, the rMDV-S1 conferred full protection to chickens against virulent MDV, as did the CVI988/Rispens strain. Conclusions Our results demonstrate that rMDV-S1 is an effective and promising recombinant vaccine for the prevention of QX-like IBV infection.

  3. Valuing the Economic Costs of Allergic Rhinitis, Acute Bronchitis, and Asthma from Exposure to Indoor Dampness and Mold in the US

    Science.gov (United States)

    2016-01-01

    Two foundational methods for estimating the total economic burden of disease are cost of illness (COI) and willingness to pay (WTP). WTP measures the full cost to society, but WTP estimates are difficult to compute and rarely available. COI methods are more often used but less likely to reflect full costs. This paper attempts to estimate the full economic cost (2014$) of illnesses resulting from exposure to dampness and mold using COI methods and WTP where the data is available. A limited sensitivity analysis of alternative methods and assumptions demonstrates a wide potential range of estimates. In the final estimates, the total annual cost to society attributable to dampness and mold is estimated to be $3.7 (2.3–4.7) billion for allergic rhinitis, $1.9 (1.1–2.3) billion for acute bronchitis, $15.1 (9.4–20.6) billion for asthma morbidity, and $1.7 (0.4–4.5) billion for asthma mortality. The corresponding costs from all causes, not limited to dampness and mold, using the same approach would be $24.8 billion for allergic rhinitis, $13.5 billion for acute bronchitis, $94.5 billion for asthma morbidity, and $10.8 billion for asthma mortality. PMID:27313630

  4. Recombinant infectious bronchitis virus (IBV) H120 vaccine strain expressing the hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) protects chickens against IBV and NDV challenge.

    Science.gov (United States)

    Yang, Xin; Zhou, Yingshun; Li, Jianan; Fu, Li; Ji, Gaosheng; Zeng, Fanya; Zhou, Long; Gao, Wenqian; Wang, Hongning

    2016-05-01

    Infectious bronchitis (IB) and Newcastle disease (ND) are common viral diseases of chickens, which are caused by infectious bronchitis virus (IBV) and Newcastle disease virus (NDV), respectively. Vaccination with live attenuated strains of IBV-H120 and NDV-LaSota are important for the control of IB and ND. However, conventional live attenuated vaccines are expensive and result in the inability to differentiate between infected and vaccinated chickens. Therefore, there is an urgent need to develop new efficacious vaccines. In this study, using a previously established reverse genetics system, we generated a recombinant IBV virus based on the IBV H120 vaccine strain expressing the haemagglutinin-neuraminidase (HN) protein of NDV. The recombinant virus, R-H120-HN/5a, exhibited growth dynamics, pathogenicity and viral titers that were similar to those of the parental IBV H120, but it had acquired hemagglutination activity from NDV. Vaccination of SPF chickens with the R-H120-HN/5a virus induced a humoral response at a level comparable to that of the LaSota/H120 commercial bivalent vaccine and provided significant protection against challenge with virulent IBV and NDV. In summary, the results of this study indicate that the IBV H120 strain could serve as an effective tool for designing vaccines against IB and other infectious diseases, and the generation of IBV R-H120-HN/5a provides a solid foundation for the development of an effective bivalent vaccine against IBV and NDV. PMID:26873815

  5. Expression, crystallization and preliminary X-ray diffraction analysis of the N-terminal domain of nsp2 from avian infectious bronchitis virus

    International Nuclear Information System (INIS)

    The N-terminal domain of nsp2 from avian infectious bronchitis virus has been purified and crystallized. The crystals diffracted to 2.5 Å resolution. Avian infectious bronchitis virus (IBV) is a prototype of the group III coronaviruses and encodes 15 nonstructural proteins which make up the transcription/replication machinery. The nsp2 protein from IBV has a unique and novel sequence and has no experimentally confirmed function in replication, whereas it has been proposed to be crucial for early viral infection and may inhibit the early host immune response. The gene that encodes a double-mutant IBV nsp2 N-terminal domain (residues 9–393 of the polyprotein, with mutations Q132L and L270F) was cloned and expressed in Escherichia coli and the protein was subjected to crystallization trials. The crystals diffracted to 2.5 Å resolution and belonged to space group P62 or P64, with unit-cell parameters a = b = 114.2, c = 61.0 Å, α = β = 90, γ = 120°. Each asymmetric unit contained one molecule

  6. Chronic Obstructive Pulmonary Disease; Jeg faar ikke puste!

    Energy Technology Data Exchange (ETDEWEB)

    Smith-Sivertsen, Eline Randers

    2004-07-01

    Many people are struggling with work-related asthma every day, which may lead to COPD, Chronic Obstructive Pulmonary Disease. COPD may be caused by illnesses like chronic bronchitis, emphysema, asthma. In serious cases of COPD, the breathing resistance has increased considerably and those suffering from it are breathing heavily. Asthma can be linked with working conditions in many ways. Exertion, cold air, and some chemical substances like sulphur dioxide can start asthma attacks. The results of early treatment or prophylactic treatment of asthma are good, but COPD is much more difficult. Although smoking is the most important cause of COPD, people who have been working for many years in highly polluted environments run a higher risk of contracting COPD. However, little is known about which specific substances are causing the disease. Particularly at risk are bakers, industrial painters, and people working in electrolysis halls in the aluminium industry. There is no effective medical treatment for COPD once the lungs have been damaged, but many hospitals offer rehabilitation.

  7. Diagnostic values of electrocardiogram in chronic obstructive pulmonary disease (COPD

    Directory of Open Access Journals (Sweden)

    Agarwal R

    2008-01-01

    Full Text Available Background : Chronic obstructive pulmonary diseases (COPD, a broad spectrum of respiratory diseases represents a worldwide problem. Electrocardiographic (ECG findings may help in clinical decision making regarding this disease entity. Aims: To evaluate the extent and diagnostic values of ECG changes among COPD patients suffering from broad spectrum of respiratory diseases. Material & Methods : A hos-pital based cross-sectional study was conducted in Sworoop Rani Nehru Hospital, Allahabad in Eastern Uttar Pradesh (UP, India. A sample of 60 patients attending respiratory diseases OPD for treatment of various respiratory problems including 14 COPD patients was selected randomly during 2000-2001. Patients of respiratory diseases were also evaluated electrocardiographically along with other investiga-tions. Results : Respiratory problems were more common among rural males of low socio-economic group. COPD particularly chronic bronchitis was the commonest respiratory problem next to pulmonary tuberculosis. Inspite of normal heart rate observed in 71.4% COPD patients, ECG changes were present in 35.7% COPD patients. Peaked P-wave was observed in 35.7% COPD patients, whereas duration of QRS complex was abnormal in only 8.1% of the patients. None of the COPD patients showed abnormal P-wave duration. ECG changes were found less sensitive (35.7% but highly specific (95.6%. Conclusion : Diagnostic values of ECG among patients with respiratory problems suggest that COPD patients should be screened electrocardiographically in addition to other clinical investigations.

  8. Chyloptysis causing plastic bronchitis

    Directory of Open Access Journals (Sweden)

    Alice Stoddart

    2014-01-01

    Full Text Available Chyloptysis is a rare clinical problem that is associated with conditions affecting lymphatic channels in the thorax. Diagnosis is usually made when the patients present with expectoration of milky-white sputum or of thick tenacious mucus in the shape of smaller bronchi (bronchial cast. Typically the symptoms resolve after coughing up of the bronchial casts. Pleural, mediastinal, pulmonary or lymphatic abnormalities result in chyloptysis. Lymphangiography and detection of lipids (cholesterol or triglycerides in sputum help to establish the diagnosis. However, lymphangiography may not be positive in all patients. We report 2 patients with chyloptysis and bronchial casts with different etiologies. Abnormal lymphatics were demonstrated in one of our cases, but the second patients lymphangiogram was normal. In this patient we suspect that high venous filling pressures due to congestive heart failure had a causative effect in the setting of compromised lymphatic drainage in the thorax due to a prior history of radiation therapy to the chest for lymphoma.

  9. Atypical Chronic Myelogenous Leukemia

    Science.gov (United States)

    ... myeloproliferative neoplasms, leukemia , and other conditions . Chronic Myelomonocytic Leukemia Key Points Chronic myelomonocytic leukemia is a disease ... chance of recovery) and treatment options. Chronic myelomonocytic leukemia is a disease in which too many myelocytes ...

  10. Experimental co-infection of SPF chickens with low pathogenicity avian influenza virus (LPAIV) subtypes H9N2, H5N2 and H7N9, and infectious bronchitis virus (IBV)

    Science.gov (United States)

    Avian influenza virus (AIV) and infectious bronchitis virus (IBV) are two of the most important respiratory viruses affecting poultry worldwide, but little is known about the effect of co-infection of these two viruses in poultry. Low pathogenicity (LP) AIV can produce from mild to moderate upper r...

  11. 阿奇霉素门诊治疗急性支气管炎疗效分析%The Efficacy of Azithromycin for Acute Bronchitis Outpatient

    Institute of Scientific and Technical Information of China (English)

    赵海伶

    2011-01-01

    目的:探讨阿奇霉素门诊治疗急性支气管炎的有效性.方法:选择142例门诊急性支气管炎患者,分为两组,青霉素组应用青霉素静脉640万单位/d静滴,阿奇霉素组应用阿奇霉素500mg加入0.9%生理盐水250mL静滴,Qd,1个疗程时,比较两组患者临床症状改善时间,确定患者临床痊愈时间和影像学痊愈时间,评价患者治疗效果.结果:阿奇霉素组咳嗽咳痰时间以及咽痛改善时间明显快于青霉素组,呼吸困难和发热改善时间差异无统计学意义,阿奇霉素组显效率明显优于青霉素治疗组,阿奇霉素组临床痊愈时间和影像学痊愈时间均明显优于青霉素组.结论:门诊急性支气管炎患者,应用阿奇霉素起效迅速,对咳嗽咳痰和咽痛改善明显,总临床疗效优于青霉素.%Objective: To investigate the azithromycin effectiveness of acute bronchitis outpatient.Method: 142 patients with acute bronchitis each were divided into two groups, penicillin group received intravenous penicillin 6.4 million units each day intravenously 500rug azithromycin were added into 250mL 0.9% saline infusion, Qd, 1 course of treatment, the Comparison of clinical symptoms improved time to determine the clinical recovery time and then evaluated patient outcomes. Result: The time of azithromycin and sore throat, cough and expectoration improve the time was faster than the penicillin group, dyspnea, and fever to improve the time difference was not statistically significant, the efficiency of azithromycin group was significantly superior to penicillin treatment group, clinical cure azithromycin group and imaging time recovery time were significantly better than the penicillin group. Conclusion: The patient with acute bronchitis,the application of azithromycin rapid onset of cough and expectoration and sore throat are significantly improved, the total clinical effective are more valider than penicillin.

  12. Estimated effect of ventilation and filtration on chronic health risks in U.S. offices, schools, and retail stores.

    Science.gov (United States)

    Chan, W R; Parthasarathy, S; Fisk, W J; McKone, T E

    2016-04-01

    We assessed the chronic health risks from inhalation exposure to volatile organic compounds (VOCs) and particulate matter (PM2.5) in U.S. offices, schools, grocery, and other retail stores and evaluated how chronic health risks were affected by changes in ventilation rates and air filtration efficiency. Representative concentrations of VOCs and PM2.5 were obtained from available data. Using a mass balance model, changes in exposure to VOCs and PM2.5 were predicted if ventilation rate were to increase or decrease by a factor of two, and if higher efficiency air filters were used. Indoor concentrations were compared to health guidelines to estimate percentage exceedances. The estimated chronic health risks associated with VOC and PM2.5 exposures in these buildings were low relative to the risks from exposures in homes. Chronic health risks were driven primarily by exposures to PM2.5 that were evaluated using disease incidence of mortality, chronic bronchitis, and non-fatal stroke. The leading cancer risk factor was exposure to formaldehyde. Using disability-adjusted life years (DALYs) to account for both cancer and non-cancer effects, results suggest that increasing ventilation alone is ineffective at reducing chronic health burdens. Other strategies, such as pollutant source control and the use of particle filtration, should also be considered. PMID:25639183

  13. Chronic urticaria

    Directory of Open Access Journals (Sweden)

    Sandeep Sachdeva

    2011-01-01

    Full Text Available Chronic urticaria (CU is a disturbing allergic condition of the skin. Although frequently benign, it may sometimes be a red flag sign of a serious internal disease. A multitude of etiologies have been implicated in the causation of CU, including physical, infective, vasculitic, psychological and idiopathic. An autoimmune basis of most of the ′idiopathic′ forms is now hypothesized. Histamine released from mast cells is the major effector in pathogenesis and it is clinically characterized by wheals that have a tendency to recur. Laboratory investigations aimed at a specific etiology are not always conclusive, though may be suggestive of an underlying condition. A clinical search for associated systemic disease is strongly advocated under appropriate circumstances. The mainstay of treatment remains H1 antihistaminics. These may be combined with complementary pharmacopeia in the form of H2 blockers, doxepin, nifedipine and leukotriene inhibitors. More radical therapy in the form of immunoglobulins, plasmapheresis and cyclophosphamide may be required for recalcitrant cases. Autologous transfusion and alternative remedies like acupuncture have prospects for future. A stepwise management results in favorable outcomes. An update on CU based on our experience with patients at a tertiary care centre is presented.

  14. [Physical and chemical markers of chronic obstructive lung disease development in industrial workers].

    Science.gov (United States)

    Muravlyova, L E; Molotov-Luchanskyi, V B; Bakirova, R E; Kliuev, D A; Kolesnikova, E A; Demidchik, L A; Beinikova, I V

    2015-01-01

    The article demonstrates that patients with chronic obstructive lung disease (COLD) of both mixed and bronchitis forms with medium severity grade appeared to have 2 types of changes in morphologic types of serum faces. Patients with various clinical forms of severe COLD presented unidirectional change in morphologic types of serum faces. Patients with various forms of moderate COLD had one variant of morphologic types of serum faces was close to that in the patients with more severe clinical course--so that face can be considered as a "transitional form" between moderate and severe COLD. These results are interesting in specifying diagnostic criteria of COLD severity and additional diagnostic criteria of the severity grade. PMID:26036016

  15. Advances in the diagnosis and treatment of children with plastic bronchitis%儿童塑型性支气管炎诊疗进展

    Institute of Scientific and Technical Information of China (English)

    张雪

    2013-01-01

    儿童塑型性支气管炎是一种较罕见的疾病,病因不明,起病隐匿,进展快,症状重,诊断和治疗难度大,病死率高.儿童塑型支气管炎被认为与某些疾病包括支气管哮喘、囊性纤维病、伴发急性胸部综合征的镰状细胞病、先天性心脏病以及各种呼吸道细菌性和病毒性感染有一定关系.关于儿童塑型性支气管炎的诊断和治疗目前仍较困难,临床医生应该警惕该病,做到早期诊断、早期治疗.%Children with plastic bronchitis,characterized by unknown origin,insidious onset,rapid progress,severe symptom and high mortality,is a relatively rare disease.Also,it is difficult to diagnose and treat with plastic bronchitis characterized by marked airway obstruction,via the formation of large gelatinous or rigid airway cast.It is associated with certain diseases including bronchial asthma,cystic fibrosis,accompanied with acute chest syndrome with sickle cell disease,congenital heart disease and bacterial and viral respiratory infection.Clinicians should be aware of this disease,and early bronchoscopy should be intervened.

  16. Construction and immunogenicity studies of recombinant fowl poxvirus containing the S1 gene of Massachusetts 41 strain of infectious bronchitis virus.

    Science.gov (United States)

    Wang, Xiuqing; Schnitzlein, William M; Tripathy, Deoki N; Girshick, Theodore; Khan, Mazhar I

    2002-01-01

    The spike 1 (S1) surface glycoprotein of infectious bronchitis virus (IBV) is the major inducer of the generation of virus neutralizing antibodies, and the administration of purified S1 has been shown to elicit a protective immune response against virulent virus challenge. On the basis of these observations, recombinant fowl poxvirus (rFPV) containing a cDNA copy of the S1 gene of IBV Mass 41 (rFPV-S1) was constructed and its immunogenicity and vaccine potential were evaluated. Initially, rFPV-S1 was shown to express the S1 in vito by indirect immunofluorescence staining and western blot analyses. Later, in vivo expression was demonstrated by the detection of IBV-specific serum immunoglobulin G and neutralization antibodies in the sera of chickens immunized with rFPV-S1. That the recombinant virus elicited anti-IBV protective immunity was indicated by the manifested, relatively mild clinical signs of disease, decreased titers of recovered challenge virus, and less severe histologic changes of the tracheas in virulent IBV Mass 41-challenged chickens previously receiving rFPV-S1 as compared with parental fowl poxvirus (FPV)-vaccinated control birds. In contrast, chickens immunized with either recombinant or parental FPV were resistant to a subsequent virulent FPV challenge. As to a preferred method of immunization, wing web administration appeared to be superior to the subcutaneous route because a greater percentage of birds vaccinated by the former protocol exhibited an anti-IBV humoral immune response. Thus, rFPV-S1 has potential as a poultry vaccine against both fowl pox and infectious bronchitis. PMID:12495043

  17. Chronic pain after hysterectomy

    DEFF Research Database (Denmark)

    Brandsborg, B; Nikolajsen, L; Kehlet, Henrik;

    2008-01-01

    BACKGROUND: Chronic pain is a well-known adverse effect of surgery, but the risk of chronic pain after gynaecological surgery is less established. METHOD: This review summarizes studies on chronic pain following hysterectomy. The underlying mechanisms and risk factors for the development of chronic...... post-hysterectomy pain are discussed. RESULTS AND CONCLUSION: Chronic pain is reported by 5-32% of women after hysterectomy. A guideline is proposed for future prospective studies. Udgivelsesdato: 2008-Mar...

  18. Untying chronic pain

    OpenAIRE

    Häuser, Winfried; Wolfe, Frederik; Henningsen, Peter; Schmutzer, Gabriele; Brähler, Elmar; Hinz, Andreas

    2014-01-01

    Background: Chronic pain is a major public health problem. The impact of stages of chronic pain adjusted for disease load on societal burden has not been assessed in population surveys. Methods: A cross-sectional survey with 4360 people aged ≥ 14 years representative of the German population was conducted. Measures obtained included demographic variables, presence of chronic pain (based on the definition of the International Association for the Study of Pain), chronic pain stages (by chronic ...

  19. Prevalence and global initiative for chronic obstructive lung disease group distribution of chronic obstructive pulmonary disease detected by preoperative pulmonary function test.

    Directory of Open Access Journals (Sweden)

    Sun Mi Choi

    Full Text Available Despite being a major public health problem, chronic obstructive pulmonary disease (COPD remains underdiagnosed, and only 2.4% COPD patients are aware of their disease in Korea. The objective of this study was to estimate the prevalence of COPD detected by spirometry performed as a preoperative screening test and to determine the Global Initiative for Chronic Obstructive Lung Disease (GOLD group distribution and self-awareness of COPD.We reviewed the medical records of adults (age, ≥ 40 years who had undergone spirometry during preoperative screening between April and August 2013 at a tertiary hospital in Korea. COPD was defined as a postbronchodilator forced expiratory volume in 1 s/forced vital capacity ratio of 40 years who had undergone spirometry as a preoperative screening test, 474 (15.6%; 404 men; median age, 70 years; range, 44-93 years were diagnosed with COPD. Only 26 (5.5% patients reported previous diagnosis of COPD (2.1%, emphysema (0.8%, or chronic bronchitis (2.5%. The GOLD group distribution was as follows: 63.3% in group A, 31.2% in group B, 1.7% in group C, and 3.8% in group D.The prevalence of COPD diagnosed by preoperative spirometry was 15.6%, and only 5.5% patients were aware of their disease. Approximately one-third of the COPD patients belonged to GOLD groups B, C, and D, which require regular treatment.

  20. 21 CFR 520.2604 - Trimeprazine tartrate and prednisolone tablets.

    Science.gov (United States)

    2010-04-01

    ... “kennel cough” or tracheobronchitis, bronchitis including allergic bronchitis, in tonsillitis, acute upper... suffering from acute or chronic bacterial infections, provided the infection is controlled by...

  1. A STUDY ON CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD PATIENTS WITH REFERENCE TO ECHOCARDIOGRAPHIC FINDINGS

    Directory of Open Access Journals (Sweden)

    Uma Sankar

    2015-12-01

    Full Text Available BACKGROUND Chronic Obstructive Pulmonary Disease (COPD is a common and preventable disease, which has great implication on global health. It is acknowledged by WHO as a commonest cause of death worldwide. The major morbidity of COPD is due to its impact on cardiac performance. Right ventricular dysfunction is common in patients with COPD. Echocardiogram is a very simple and convenient bedside investigation to detect cardiac function and structure. OBJECTIVE To study the clinical profile, echocardiographic findings of COPD patients and to correlate the echocardiographic findings with the severity of the disease. MATERIAL METHOD A total of 100 patients admitted in the Department of Medicine of Silchar Medical College during the period from June 2013 to May 2014 were selected and detailed clinical examination, pulmonary funtion test, Chest X-Ray, ECG and Echocardiogram were done in all cases. RESULT Mean age of the patients was 61+8.6 years and highest 46% were in the age group of 61 to 70 years and 86% were male. Highest number 64% were farmers residing in rural area (83%; 89% of patients were smoker presented with cough (97%, expectoration of sputum (93% and dyspnoea (91%. The patient had pedal oedema (65%, raised JVP (56% and cynosis (43%. In 94% pulmonary rales, 79% use of accessory muscle of respiration, 74% ronchi and 52% barrel shaped chest was found. In chest X-ray 49% had chronic bronchitis and another 49% emphysema. Pulmonary function test revealed severe obstruction in 50% and moderate obstruction in 46%. ECG revealed P-Pulmonale (51%, Right axis deviation (45%, RVH (39% and RBBB (31%. Echocardiogram shows dilated right ventricle (53%, Pulmonary hypertension (53%, right atrial enlargement (42% and right ventricular hypertrophy (26%. In the moderate severe COPD 32.60% (15 out of 46 had dilatation of right ventricle and pulmonary hypertension. Only 8.69% had right atrial enlargement. In severe group 76% had right atrial enlargement

  2. Discrepancy between presumptive and definite causes of chronic cough

    Institute of Scientific and Technical Information of China (English)

    YU Li; QIU Zhi-hong; WEI Wei-li; LIU Bo; XU Xiang-huai; L(U) Han-jing; QIU Zhong-min

    2011-01-01

    Background The current diagnostic algorithms for chronic cough require the establishment of the primary presumptive causes followed by the confirmation of diagnosis with the specific therapies.The aim of the study was to investigate the discrepancy between presumptive and definite causes and its clinical implication.Methods A total of 109 patients with chronic cough underwent laboratory investigations to identify the cause of cough; including sinus computerized tomography (if needed),histamine bronchial provocation,induced sputum cytology and 24-hour esophageal pH or multi-channel intraluminal impedance combined with pH monitoring.The presumptive causes were confirmed by treating them sequentially.The difference between presumptive and definite causes of chronic cough was compared.Results Single cause was more frequent in the definite diagnosis than in the presumptive diagnosis (78.9% vs.54.1%,x2=15.01,P=0.0001).In contrast,multiple causes were significantly fewer in definite diagnosis than in the presumptive diagnosis (15.6% vs.37.6%,x2=13.53,P=0.0002).There was a discrepancy between definite and presumptive causes in 30 patients (27.5%).Compared with the presumptive causes,definite upper airway cough syndrome (24.8% vs.11.9%,x2=6.0,P=0.01) and gastroesophageal reflux disease (6.4% vs.0,x2=7.23,P=0.007) was more frequent as a single cause of chronic cough while cough variant asthma plus gastroesophageal reflux disease (3.7% vs.11.9%,x2=5.17,P=0.02) and upper airway cough syndrome plus nonasthmatic eosinophilic bronchitis (0 vs.9.2%,x2=10.48,P=0.001) were fewer as multiple causes of chronic cough.Conclusions A discrepancy was common between presumptive and definite causes of chronic cough.To treat presumptive causes sequentially may be a suitable solution for avoidance of erroneous multiple causes and possible over-treatment.

  3. 小儿肺咳颗粒对急性小儿支气管炎治疗的临床观察%Clinical Effects of Pediatric Lung Cough Particles on Acute Bronchitis in Children

    Institute of Scientific and Technical Information of China (English)

    王晴晴; 过桥

    2014-01-01

    Objective:To study the clinical effects of Pediatric Lung Cough Particles on acute bronchitis in children.Method:280 patients with acute bronchitis from July 2012 to July 2014 in our hospital were studied.The patients were randomly divided into two groups,the observation group,200 cases (Pediatric Lung Cough Particles),and the control group,80 cases (cefotaxime by intravenous dripping).The clinical symptoms,clinical signs and symptoms score to quantify adverse reactions were observed. A course of treatment to determine efficacy.Result:The clinical signs and symptoms score of the two groups were all significantly reducing(P0.05)。结论:小儿肺咳颗粒治疗急性小儿支气管炎有显著效果,值得在临床上推广。

  4. Chronic recurrent hemoptysis: effectiveness of bronchial artery embolization in 25 patients

    International Nuclear Information System (INIS)

    Bronchial artery embolization has been effective in the treatment of massive hemoptysis. The purpose of this study was to report the effectiveness of bronchial artery embolization in patients with chronic recurrent hemoptysis intractable to medical treatment. This study included 25 patients who were admitted for treatment of chronic recurrent hemoptysis with bronchial artery embolization. Chronic recurrent hemoptysis was defined as condition in tractable to medical treatment persistently and occurring over two times per two months The target vessels for embolization were selected in consideration of the results of aortography as well as the finding of chest radiography and bronchoscopy. After selective arteriography for embolization by using 5-French Simmons catheter, embolic agents(mainly polyvinyl alcohol(PVA) and additionally gelfoam and coils) were released through the catheter. The results of the embolization were assessed with review of medical records. The cases of the hemoptysis were pulmonary tuberculosis(n=12.48%), bronchiectasis(n=6.24%), aspergilloma(n=3.12%), chronic obstructive pulmonary disease(n=2.8%), chronic bronchitis(n=1.4%) and lung abscess(n=1.4%). Selective embolization was carried out in 49 sites(42 in bronchial artery and 7 in nonbronchial systemic collaterals). Early success rate within 2 months was 96%. After long-term follow up study (6-30 months, average 15 months), complete remission was 72%, partial remission 12% and recurrence 12% respectively. During and after embolization, major complications such as spinal cord injury or bronchial wall necrosis was not found. Minor complications were chest pain, shoulder pain and chilling sense, which were relieved spontaneously within a few days. High success rate and relatively low recurrence with no significant complication were achieved with bronchial artery embolization in the patients complaining of chronic recurrent hemoptysis

  5. SEROLOGIC DYNAMIC OF INFECTIO US BRONCHITIS VIRUS IN A BROILER FLOCK IN CUNDINAMARCA DINÁMICA SEROLÓGICA DEL VIRUS DE BRONQUITIS INFECCIOSA EN UNA GRANJA DE POLLO DE ENGORDE DEL DEPARTAMENTO DE CUNDINAMARCA

    OpenAIRE

    Vera Alfonso Victor Julio; Jaime Correa Jairo; Usma Jorge Alberto; Alvarez Espejo Diana Claudia

    2009-01-01

    The infectious bronchitis virus (IBV) causes a highly contagious disease, spread worldwide, leading to serious economic losses. Sometimes the disease is associated with other entities such as infectious bursal disease virus, Newcastle disease virus, Mycoplasma gallisepticum and Escherichia coli. The highly genetic variability of the virus has generated a large number of viral strains with different clinical presentations. The objective was to assess the dynamics of the virus antibodies in bir...

  6. Chronic granulomatous disease

    Science.gov (United States)

    CGD; Fatal granulomatosis of childhood; Chronic granulomatous disease of childhood; Progressive septic granulomatosis ... In chronic granulomatous disease (CGD), immune system cells called ... some types of bacteria and fungi. This disorder leads to long- ...

  7. People Experiencing Chronic Homelessness

    Science.gov (United States)

    ... Experiencing Chronic Homelessness Share This: People Experiencing Chronic Homelessness We've made significant progress in our national ... the USICH newsletter. We know how to end homelessness. Let's do it, together. Sign up for our ...

  8. Chronic motor tic disorder

    Science.gov (United States)

    Chronic motor tic disorder is more common than Tourette syndrome . Chronic tics may be forms of Tourette syndrome. Tics usually start at age 5 or 6 and get worse until age 12. They often improve during adulthood.

  9. Chronic Diarrhea in Children

    Science.gov (United States)

    ... can include cramping abdominal pain nausea or vomiting fever chills bloody stools Children with chronic diarrhea who have ... can include cramping, abdominal pain, nausea or vomiting, fever, chills, or bloody stools. Children with chronic diarrhea who ...

  10. "Chronic Lyme Disease"

    Science.gov (United States)

    ... Content Marketing Share this: Main Content Area "Chronic Lyme Disease" What is "chronic Lyme disease?" Lyme disease is an infection caused by ... J Med 357:1422-30, 2008). How is Lyme disease treated? For early Lyme disease, a short ...

  11. Prostaglandins and chronic inflammation

    OpenAIRE

    Aoki, Tomohiro; Narumiya, Shuh

    2012-01-01

    Chronic inflammation is the basis of various chronic illnesses including cancer and vascular diseases. However, much has yet to be learned how inflammation becomes chronic. Prostaglandins (PGs) are well established as mediators of acute inflammation, and recent studies in experimental animals have provided evidence that they also function in transition to and maintenance of chronic inflammation. One role PGs play in such processes is amplification of cytokine signaling. As such, PGs can facil...

  12. Treating 50 cases of acute bronchitis in children with Zhisou powder plus Sanzi Yangqin decoction%止嗽散合三子养亲汤治疗小儿急性支气管炎50例

    Institute of Scientific and Technical Information of China (English)

    王云蝶; 孙真香

    2014-01-01

    Objective: To observe the efficacy on treating acute bronchitis in children with Zhisou powder plus Sanzi Yangqin decoction. Methods: 50 cases of acute bronchitis in children treated with Zhisou powder plus Sanzi Yangqin decoction, statistical effect after 7 days. Results:39 cases were cured, 7 cases improved, 4 cases ineffective, the total efficiency was 92%. Conclusion:Zhisou powder plus Sanzi Yangqin decoction is effective on treating acute bronchitis in children, worthy of a wide clinical application.%目的:观察止嗽散合三子养亲汤治疗小儿急性支气管炎的疗效。方法:将50例急性支气管炎患儿予止嗽散合三子养亲汤7d后统计疗效。结果:治愈39例,好转7例,未愈4例,总有效率92%。结论:采用止嗽散合三子养亲汤治疗小儿急性支气管炎,疗效显著,值得临床推广应用。

  13. Chronic Inflammatory Demyelinating Polyneuropathy

    OpenAIRE

    Dimachkie, Mazen M.; Barohn, Richard J.

    2013-01-01

    Chronic Inflammatory polyneuropathies are an important group of neuromuscular disorders that present chronically and progress over more than 8 weeks, being referred to as chronic inflammatory demyelinating polyneuropathy (CIDP). Despite tremendous progress in elucidating disease pathogenesis, the exact triggering event remains unknown. Our knowledge regarding diagnosis and management of CIDP and its variants continues to expand, resulting in improved opportunities for identification and treat...

  14. Molecular detection of infectious bronchitis virus and it is relation with avian influenza virus (H9 and Mycoplasma gallisepticum from different geographical regions in Iraq

    Directory of Open Access Journals (Sweden)

    A.H. Al-Dabhawe

    2013-12-01

    Full Text Available Infectious bronchitis virus (IBV, Avian influenza virus (AIV and Mycoplasma gallisepticum (MG have been recognized as the most important pathogens in poultry cause acute respiratory infection and serous economic problems in Iraq and many other countries all over the world. This study was conducted to investigate the distribution of these diseases in commercial chicken flocks in different geographical region in middle part of Iraq by using qPCR. Tracheal swabs and tissue specimens from trachea, lung and kidney were taken from 38 different cases from commercial broiler chicken flocks in (Najaf, Hilla, Muthana and Theqaar governorates in the period from November 2010 to June 2011, all these flocks were showed respiratory symptoms and mortality about 20-90%. The results showed that 92.1% of samples collected from these flocks were infected with IBV, 20% of samples were infected with IB alone and 45.71% of samples with IB combined with both GM and AIV subtype H9 and 25.71% of samples were positive to both IBV and AIV(H9. No samples were positive to AIV (H9 or MG alone. Because of importance of respiratory diseases as a most common conditions noted in commercial flocks in Iraq and no previous study detecting this pathogens by molecular techniques, this study come to detect and confirm the diagnosis of this pathogens by qPCR as new technique used in this field in Iraq.

  15. Inhaler use in adolescents and adults with self-reported physician-diagnosed asthma, bronchitis, or emphysema in the city of Pelotas, Brazil

    Directory of Open Access Journals (Sweden)

    Paula Duarte de Oliveira

    2013-06-01

    Full Text Available OBJECTIVE: To evaluate the characteristics of users of inhalers and the prevalence of inhaler use among adolescents and adults with self-reported physician-diagnosed asthma, bronchitis, or emphysema. METHODS: A population-based study conducted in the city of Pelotas, Brazil, involving 3,670 subjects ≥ 10 years of age, evaluated with a questionnaire. RESULTS: Approximately 10% of the sample reported at least one of the respiratory diseases studied. Among those individuals, 59% reported respiratory symptoms in the last year, and, of those, only half reported using inhalers. The use of inhalers differed significantly by socioeconomic status (39% and 61% for the lowest and the highest, respectively, p = 0.01. The frequency of inhaler use did not differ by gender or age. Among the individuals reporting emphysema and inhaler use, the use of the bronchodilator-corticosteroid combination was more common than was that of a bronchodilator alone. Only among the individuals reporting physician-diagnosed asthma and current symptoms was the proportion of inhaler users higher than 50%. CONCLUSIONS: In our sample, inhalers were underutilized, and the type of medication used by the individuals who reported emphysema does not seem to be in accordance with the consensus recommendations.

  16. Eggshell apex abnormalities in a free-range hen farm with mycoplasma synoviae and infectious bronchitis virus in Rio de Janeiro state, Brazil

    Directory of Open Access Journals (Sweden)

    FC dos Santos

    2014-06-01

    Full Text Available A farm with 3,000 free-range hens between 24 and 65 weeks of age was investigated. These hens were separated in small flocks of 400 to 700 birds, presenting 10 to 23% egg production reduction. Twenty serum samples were collected during the period of drop in egg production and three weeks later for the investigation of Mycoplasma synoviae (MS, M. gallisepticum (MG and Infectious Bronchitis Virus (IBV antibodies using ELISA. At the time of the second collection, egg production had resumed to normal levels; however, with 10.23% of the eggs showed eggshell abnormalities limited to the apex. Eggshell strength was significantly different between normal and those with eggshell apex abnormalities, but not other egg-quality parameters. ELISA tests showed that MS and IBV titers increased during the evaluated period. MS infection was confirmed by culture and by PCR of tracheal swabs. All samples were negative for MG by ELISA and PCR. Further studies with larger samples to ensure the occurrence of this disease in industrial layer flocks in Brazil are under way.

  17. Fine level epitope mapping and conservation analysis of two novel linear B-cell epitopes of the avian infectious bronchitis coronavirus nucleocapsid protein.

    Science.gov (United States)

    Han, Zongxi; Zhao, Fei; Shao, Yuhao; Liu, Xiaoli; Kong, Xiangang; Song, Yang; Liu, Shengwang

    2013-01-01

    The nucleocapsid (N) protein of the infectious bronchitis virus (IBV) may play an essential role in the replication and translation of viral RNA. The N protein can also induce high titers of cross-reactive antibodies and cell-mediated immunity, which protects chickens from acute infection. In this study, we generated two monoclonal antibodies (mAbs), designated as 6D10 and 4F10, which were directed against the N protein of IBV using the whole viral particles as immunogens. Both of the mAbs do not cross react with Newcastle disease virus (NDV), infectious laryngotracheitis virus (ILTV) and subtype H9 avian influenza virus (AIV). After screening a phage display peptide library and peptide scanning, we identified two linear B-cell epitopes that were recognized by the mAbs 6D10 and 4F10, which corresponded to the amino acid sequences (242)FGPRTK(247) and (195)DLIARAAKI(203), respectively, in the IBV N protein. Alignments of amino acid sequences from a large number of IBV isolates indicated that the two epitopes, especially (242)FGPRTK(247), were well conserved among IBV strains. This conclusion was further confirmed by the relationships of 18 heterologous sequences to the 2 mAbs. The novel mAbs and the epitopes identified will be useful for developing diagnostic assays for IBV infections. PMID:23123213

  18. A recombinant turkey herpesvirus expressing chicken interleukin-2 increases the protection provided by in ovo vaccination with infectious bursal disease and infectious bronchitis virus.

    Science.gov (United States)

    Tarpey, I; van Loon, A A; de Haas, N; Davis, P J; Orbell, S; Cavanagh, D; Britton, P; Casais, R; Sondermeijer, P; Sundick, R

    2007-12-12

    In ovo vaccination remains an attractive option for the mass application of vaccines to poultry, ensuring a uniform application of vaccine in a cost-effective manner. However, the number of vaccines that can be delivered safely by this method is limited. Several infectious bursal disease virus (IBDV) vaccines can be given in ovo though most are delivered post-hatch and there are no currently licensed embryo-safe infectious bronchitis virus (IBV) vaccines. Reduction in the dose of vaccines given in ovo is one possibility to ensure embryo safety though efficacy can be reduced when low doses are used. We have investigated the use of embryo-safe IBDV and IBV vaccines and the effects of co-delivery of a turkey herpesvirus recombinant expressing bioactive chicken IL-2 (IL-2/HVT). Co-delivery of the IL-2/HVT with low doses of the IBDV or IBV vaccines significantly increased the antibody response against these viruses. In addition the protection against challenge with virulent IBDV or IBV was increased significantly. This suggests that the co-delivery of IL-2/HVT with low doses of other vaccines in ovo may be one method to increase the number of vaccines that can be given safely and efficaciously via in ovo vaccination. PMID:17996994

  19. Tissue distribution of avian infectious bronchitis virus following in ovo inoculation of chicken embryos examined by in situ hybridization with antisense digoxigenin-labeled universal riboprobe.

    Science.gov (United States)

    Lee, Chang-Won; Brown, Corrie; Jackwood, Mark W

    2002-09-01

    Chicken embryos were inoculated with 8 different strains of infectious bronchitis virus (IBV) representing 7 different serotypes at 17 days of embryonation. At 2 and 5 days postinfection (dpi), tissues were collected for in situ hybridization using an antisense digoxigenin-labeled riboprobe corresponding to the sequence of the mRNA coding for the membrane protein. Extensive antigen staining in the cytoplasm of epithelial cells in the trachea, lung, bursa, and intestine was detected at 2 dpi with all 8 strains of IBV. At 5 dpi, little or no positive staining was observed in these tissues. However, tubular cells of the kidney showed multifocal positive staining with the Wolgemuth strain-, Gray strain-, JMK strain-, and Mass41 strain-infected chickens. No viral RNA was detected in the spleen at any time point. The results demonstrated strict epitheliotropic nature and wide tissue tropism of strains of IBV in the chicken embryo and the universality of our riboprobe. In situ hybridization with this probe will be useful for understanding the tissue tropism and the pathogenesis of IBV in vivo. PMID:12296388

  20. Chronic granulomatous disease associated with chronic glomerulonephritis

    DEFF Research Database (Denmark)

    Frifelt, J J; Schønheyder, Henrik Carl; Valerius, Niels Henrik;

    1985-01-01

    A boy with chronic granulomatous disease (CGD) developed glomerulonephritis at the age of 12 years. The glomerulonephritis progressed to terminal uraemia at age 15 when maintenance haemodialysis was started. The clinical course was complicated by pulmonary aspergillosis and Pseudomonas septicaemia...

  1. Pulmonary perfusion scintigraphy in children with chronic pulmonary damage: Preliminary results from application of the SPECT technique

    International Nuclear Information System (INIS)

    The aim was to describe lung perfusion SPECT (LPS) findings in children with chronic pulmonary damage. Material and Method: We revised 106 LPS of children (age:3.9 ± 3.3 yr) with chronic pulmonary damage, performed with a two headed gamma camera. The most common clinical diagnosis were adenovirus bronchopneumonia sequelae (ADV)(29%), unknown origin chronic pulmonary damage (UOPD) (21%), bronchopulmonary dysplasia (BPD)(15%), and chronic obstructed bronchitis (COB)(14%). Severity of pulmonary alterations were evaluated using a Score, which considered extent and type of lung involvement and differential pulmonary perfusion. Pattern of involvement and Score were correlated with diagnosis and gender. Results: Ninety one percent (96/106) of LPS were abnormal (62% boys). Fifty two (54%) showed bilateral alterations, being this finding (p:0.019) more frequent in boys. ADV group showed mainly a mixed bilateral pattern (35%), UOPD a focal unilateral pattern (32%), COB a diffuse unilateral pattern (33%), and BPD a normal pattern (25%). Miscellaneous and UOPD showed the highest score values, and BPD and COB the lowest ones. Conclusion: In this population, LPS is abnormal in high proportion, with some differential characteristics according gender and original diagnosis (au)

  2. 24-HOUR ARTERIAL STIFFNESS VALUES IN MEN WITH DIFFERENT PHENOTYPES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE CONCURRENT WITH HYPERTENSION

    Directory of Open Access Journals (Sweden)

    N. A. Karoli

    2015-01-01

    Full Text Available Objective: to study the specific features of the daily arterial stiffness (AS profile in men with different phenotypes of chronic obstructive pulmonary disease (COPD concurrent with hypertension. Subjects and methods. The investigation enrolled 78 male patients with COPD and hypertension. The patients were divided according to COPD phenotypes into 2 groups: 1 COPD patients with emphysema; 2 those with bronchitis. The exclusion criteria were less than 40 years and more than 80 years of age; diabetes mellitus; coronary heart disease; vascular diseases; an exacerbation of chronic diseases; bronchial and pulmonary diseases of another etiology. The patients underwent 24-hour blood pressure and AS monitoring, external respiratory function testing: spirography with a short-acting β2-agonist test, a six-minute walk test at baseline and after a hemoglobin oxygen saturation test, and a CAT test. Results. The patients of both groups were observed to have a statistically significant increase in (dP/dtmax as compared to those of the control group (p < 0.05; p < 0.01 in both the daytime and nighttime. In these periods, the COPD patients with emphysema had a higher AIx than those with bronchitis (p < 0.001. There was a statistically significantly (p < 0.001 higher AIx in the nighttime than in the daytime in Groups 1 and 2 patients. Conclusion. The patients with different COPD phenotypes were noted to have impaired arterial elastic properties, circadian AS changes with predominantly nocturnal impaired vascular stiffness. Relationships were found between 24-hour AS values and clinicoanamnestic findings. 

  3. Contribution of pulmonary emphysema to functional impairment in patients with severe chronic obstructive pulmonary disease. A high-resolution CT study

    International Nuclear Information System (INIS)

    The purpose of the paper is to investigate whether high-resolution CT (HRCT) can detect the subjects with massive emphysematous destruction in a group of patients with severe chronic obstructive pulmonary disease (COPD) and therefor be of help in selecting the candidates to surgical lung volume reduction. Have been examined 40 former smokers with severe COPD (FEV1≤40% of the predicted value, with no major improvement after inhalation of bronchodilators). The emphysema extent score was significantly correlated with the hematocrit value and Tiffeneau index (p1 was significantly correlated with emphysema extent (p<1) in dyspnoeic, but not in bronchitis, patients. Moreover, the former had better arterial blood gas and lower hematocrit values. HRCT is a useful tool in diagnosing the presence of emphysema in vivo and in assessing its extent in COPD patients because it permits to divide the patients in two groups which roughly correspond to the clinical patterns of types A (dyspnoeic) and B (bronchitis). Severe emphysema patients are the best candidates to surgical lung volume reduction. Airways involvement might play a major role in causing bronchial obstruction in the subjects with mild emphysema. In these series HRCT did assess the severity of emphysema in COPD subjects, but the lung function screening failed to predict emphysema extent

  4. Chronic diseases in adolescence

    OpenAIRE

    Rončević Nevenka; Stojadinović Aleksandra; Odri Irena

    2006-01-01

    Introduction. The prevalence of chronic diseases in adolescence is constantly increasing, especially in the last two decades. Adolescence is a period of important changes: body growth and development, sexual development, development of cognitive abilities, change in family relations and between peers, formation of personal identity and personal system of values, making decisions on future occupation etc. Chronic diseases in adolescence. Chronic disorders affect all development issues and repr...

  5. Chronic penile strangulation

    OpenAIRE

    Lopes, Roberto I.; Silvia I Lopes; Roberto N. Lopes

    2003-01-01

    Chronic penile strangulation is exceedingly rare with only 5 cases previously reported. We report an additional case of progressive penile lymphedema due to chronic intermittent strangulation caused by a rubber band applied to the penile base for 6 years. A 49-year-old man presented incapacity to exteriorize the glans penis. For erotic purposes, he had been using a rubber-enlarging band placed in the penile base for 6 years. With chronic use, he noticed that his penis swelled. Physical examin...

  6. Chronic Granulomatous Disease (CGD)

    Science.gov (United States)

    ... Share this: Main Content Area Chronic Granulomatous Disease (CGD) Phagocyte (purple) engulfing Staphylococcus aureus bacteria (yellow). Credit: NIAID CGD is a genetic disorder in which white blood ...

  7. Chronic silent otitis media.

    Science.gov (United States)

    Paparella, Michael M; Schachern, Patricia A; Cureoglu, Sebahattin

    2002-01-01

    Otitis media occurs along a continuum. For example, otitis media with effusion characterized by fluid pathology can lead to chronic otitis media plus chronic mastoiditis, characterized by the presence of intractable tissue pathology such as cholesteatoma, cholesterol granuloma or granulation tissue. The literature defines chronic otitis media as having a tympanic membrane perforation and otorrhea. Amongst many other sequelae, which can result from the continuum, an important common one is chronic silent otitis media. This overlooked entity which includes pathology beneath an intact tympanic membrane is commonly seen in our human temporal bone laboratory and in patients. The clinical pathological correlates of this important disease are discussed herein. PMID:12021496

  8. Using oxygen at home

    Science.gov (United States)

    Oxygen - home use; COPD - home oxygen; Chronic obstructive airways disease - home oxygen; Chronic obstructive lung disease - home oxygen; Chronic bronchitis - home oxygen; Emphysema - home oxygen; Chronic respiratory ...

  9. 鸡传染性支气管炎病毒的分离与鉴定%solation and Identification of Avian Infectious Bronchitis Virus

    Institute of Scientific and Technical Information of China (English)

    王正东; 余弟和; 张建军; 魏波

    2012-01-01

    [Objective]The aim of the study was to isolate an avian infectious bronchitis virus(IBV) isolate from the diseased chickens and identity its characteristics. [Method] An 1BV isolate was isolated from the diseased chickens in a chicken farm in Anhui Province and passaged blindly in chicken embryos to observe its pathogenicity. Then animal regression test was used to replicate bronchial congestion in SPF chickens. The SI gene fragment was amplified and its sequence was aligned with the IBV vaccine strains. [ Result ] The results of HA assay showed that the allantoic fluid of the IBV strain had no agglutination activity toward chicken red blood cells. This result suggested that no Newcastle disease virus and avian influenza virus were found in the allantoic fluid. However,the allanloic fluid treated with 10 g/L trypsin solution could agglutinate chicken red blood cells, which is in line with the biological characteristics of IBV. After the SPF chickens were inoculated with the sixth passage of the IBV I-solate, the clinical symptoms like bronchial congestion that were similar with those in clinic were observed. The results initially confirmed the isolation of an IBV isolate,which was named IBV XZ strain. [Conclusion]This study provides a theoretical basis for the prevention and treatment of avian infectious bronchitis.%[目的]从发病鸡群中分离出鸡传染性支气管炎病毒,并对其进行鉴定.[方法]从安徽某鸡场发病鸡群中分离出鸡传染性支气管是病毒,采用鸡胚盲传,观察病毒对鸡胚的致病作用.通过动物回归试验,在SPF鸡上复制出支气管堵塞的症状,扩增分离毒株的S1基因片段,并与IBV疫苗毒株进行比较.[结果]对分离到的毒株进行HA检测,结果表明收获的尿囊液对鸡红细胞无凝集活性,说明分离到的病毒中无NDV、AIV等,但经1%胰酶处理则可凝集鸡红细胞,符合传染性支气管炎病毒的生物学特征.该毒株的第6代SPF鸡胚尿囊液通过滴

  10. [Sequencing and Serologic Identification of S1 Genes of Infectious Bronchitis Viruses Isolated during 2012-2013 in Guangxi Province, China].

    Science.gov (United States)

    Zhang, Lihua; Wu, Cuilan; Zhang, Zhipeng; He, Yining; Li, Heming; Qin, Lili; Wei, Tianchao; Mo, Meilan; Wei, Ping

    2016-01-01

    We wished to ascertain the prevalence as well as the genetic and antigenic variation of infectious bronchitis viruses (IBVs) circulating in the Guangxi Province of China in recent years. The S1 gene of 15 IBV field isolates during 2012-2013 underwent analyses in terms of the similarity of amino-acid sequences, creation of phylogenetic trees, recombination, and serologic identification. Similarities in amino-acid sequences among the 15 isolates of the S1 gene were 54.3%-99.6%, and 43.3%-99.3% among 15 isolates and reference strains. Compared with the vaccine strain H120, except for GX-YL130025, the other 14 isolates showed a lower similarity of amino-acid sequences of the S1 gene (65.1-81.4%). Phylogenetic analyses of the S1 gene suggested that 15 IBV isolates were classified into eight genotypes, with the predominant genotype being new-type II. Recombination analyses demonstrated that the S1 gene of the GX-NN130048 isolate originated from recombination events between vaccine strain 4/91 and a LX4-like isolate. Serotyping results suggested that seven serotypes prevailed during 2012-2013 in Guangxi Province, and that only one isolate was consistent with the vaccine strain H120 in serotype (which has been used widely in recent years). The serotype of recombinant isolate GX-NN130048 was different from those of its parent strains. These results suggested that not only the genotype, but also the serotype of IBV field isolates in Guangxi Province had distinct variations, and that increasing numbers of genotypes and serotypes are in circulation. We showed that recombination events can lead to the emergence of new serotypes. Our study provides new evidence for understanding of the molecular mechanisms of IBV variations, and the development of new vaccines against IBVs. PMID:27295885

  11. Genetic Diversity of Spike, 3a, 3b and E Genes of Infectious Bronchitis Viruses and Emergence of New Recombinants in Korea

    Directory of Open Access Journals (Sweden)

    Chang-Seon Song

    2013-01-01

    Full Text Available The nucleotide sequences of a region including S1, S2, 3a, 3b and E genes of twenty-seven infectious bronchitis virus (IBV isolates in Korea between 1990–2011 were determined and phylogenetic and computational recombination analyses were conducted. The sizes of coding regions of some genes varied among IBV isolates due to deletion or insertion of nucleotides; the nucleotide similarities of S1, S2, 3a, 3b and E genes among the 27 isolates were 75.9%–100.0%, 85%–100.0%, 64.0%–100.0%, 60.4%–100.0% and 83.1%–100.0%, respectively. According to phylogenetic analysis of S1 gene, the 27 isolates were divided into five genotypes, Mass, Korean-I (K-I, QX-like, KM91-like and New cluster 1. The phylogenetic trees based on the S2, 3a, 3b, E genes and S1-S2-3a-3b-E (S1-E region nucleotide sequences did not closely follow the clustering based on the S1 sequence. The New cluster 1 prevalent during 2009 and 2010 was not found in 2011 but QX-like viruses became prevalent in 2011. The recombination analysis revealed two new S gene recombinants, 11036 and 11052 which might have been derived from recombinations between the New cluster 1 and QX-like viruses and between the K-I and H120 (vaccine viruses, respectively. In conclusion, multiple IBV genotypes have co-circulated; QX-like viruses have recurred and new recombinants have emerged in Korea. This has enriched molecular epidemiology information of IBV and is useful for the control of IB in Korea.

  12. Correlation between high-resolution computed tomography features and patients′ characteristics in chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Gupta Prem

    2008-01-01

    Full Text Available Background: During the last few decades, high-resolution computed tomography (HRCT has come up as a new diagnostic modality to diagnose emphysematous and chronic bronchitis components of chronic obstructive pulmonary disease (COPD. The present study was undertaken to evaluate for various quantitative and qualitative HRCT features in patients with COPD, and to detect patients′ characteristics that correlate with these HRCT features. Materials and Methods: Forty male patients with COPD attending the COPD clinic at a tertiary referral hospital and postgraduate medical institute were included in the study. Various HRCT features, including tracheal index, thoracic cage ratio, sterno-aortic distance, thoracic cross-sectional area, vascular attenuation, vascular distortion, mosaic attenuation pattern, and directly visible small airways, were evaluated and correlated with patients′ characteristics, including age, duration of illness, quantum of smoking, dyspnea score, quality-of-life index, and various spirometric indices. Results: We found significant correlations of various quantitative and qualitative HRCT features with age, duration of illness, quantum of smoking, quality-of-life index, and the spirometric indices showing the extent of airways obstruction. Conclusions: Various quantitative and qualitative HRCT features were found to correlate with patients′ characteristics, spirometric indices, and health-related quality-of-life score, suggesting that HRCT is useful not only in detecting emphysema and its various subtypes but also in predicting the extent and severity of COPD

  13. THE EFFECTS OF PRACTICING SWIMMING IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE. CASE STUDY

    Directory of Open Access Journals (Sweden)

    Petrescu S.

    2015-08-01

    Full Text Available Chronic obstructive pulmonary disease (COPD is comprised primarily of two related diseases - chronic bronchitis and emphysema. Clinical research on the effects of swimming on the quality of the life of patients with various lung diseases showed that the use of water therapy programs have significant effects on the induction of pulmonary edema as well as on mild to moderate asthma. The case study presented in this study, aged 52, male, from urban area, smoker (30PA, with a weight of 96 kg and a height of 168 cm, was diagnosed with COPD in GOLD III std about 2 years ago and abdominal obesity. The functional examinations have revealed a mixed ventilatory dysfunction with FEV of 48.6% and 68.3% CV. The therapy with tiotropium and beta 2 agonists initiated as needed, along with physical therapy. After the application of aquatic programs for 6 months the results have highlighted significant changes in the lung functionality and the quality of everyday life.

  14. Chronic health effects of sulphur mustard exposure with special reference to Iranian veterans

    Directory of Open Access Journals (Sweden)

    B Balali-Mood

    2008-01-01

    Full Text Available The widespread use of sulphur mustard (SM as an incapacitating chemical warfare agent in the past century has proved its long-lasting toxic effects. It may also be used as a chemical terrorist agent. Therefore, all health professionals should have sufficient knowledge and be prepared for any such chemical attack. SM exerts direct toxic effects on the eyes, skin, and respiratory tissue, with subsequent systemic action on the nervous, immunological, haematological, digestive, and reproductive systems. SM is an alkylating agent that affects DNA synthesis, and, thus, delayed complications have been seen since the First World War. Cases of malignancies in the target organs, particularly in haematopoietic, respiratory, and digestive systems, have been reported. Important delayed respiratory complications include chronic bronchitis, bronchiectasis, frequent bronchopneumonia, and pulmonary fibrosis, all of which tend to deteriorate with time. Severe dry skin, delayed keratitis, and reduction of natural killer cells with subsequent increased risk of infections and malignancies are also among the most distressing long-term consequences of SM intoxication. However, despite a lot of research over the past decades on Iranian veterans, there are still major gaps in the SM literature. Immunological and neurological dysfunction, as well as the relationship between SM exposure and mutagenicity, carcinogenicity, and teratogenicity are important fields that require further studies, particularly on Iranian veterans with chronic health effects of SM poisoning. There is also a paucity of information on the medical management of acute and delayed toxic effects of SM poisoning—a subject that greatly challenges health care specialists.

  15. Chronic respiratory diseases and quality of life in elderly nursing home residents.

    Science.gov (United States)

    Carreiro-Martins, Pedro; Gomes-Belo, Joana; Papoila, Ana Luísa; Caires, Iolanda; Palmeiro, Teresa; Gaspar-Marques, João; Leiria-Pinto, Paula; Mendes, Ana Sofia; Paulo-Teixeira, João; Botelho, Maria Amália; Neuparth, Nuno

    2016-08-01

    Few studies have assessed the quality of life (QOL) related to chronic respiratory diseases in the elderly. In the framework of the geriatric study on the health effects of air quality in elderly care centers (GERIA) study, a questionnaire was completed by elderly subjects from 53 selected nursing homes. It included various sections in order to assess respiratory complaints, QOL (World Health Organization QOL (WHOQOL)-BREF), and the cognitive and depression status. The outcome variables were the presence of a score lower than 50 (current wheezing, asthma, and allergic rhinitis were considered as potential risk factors. The surveyed sample was (n = 887) 79% female, with a mean age of 84 years (SD: 7 years). In the multivariable analysis, a score of <50 in the physical domain was associated with wheezing in the previous 12 months (odds ratio (OR): 2.03, confidence interval (CI): 1.25-3.31) and asthma (OR: 1.95, CI: 1.12-3.38). The psychological domain was related with a frequent cough (OR: 1.43, CI: 0.95-2.91). A score of <50 in the environmental domain was associated with chronic bronchitis (OR: 2.89, CI: 1.34-6.23) and emphysema (OR: 3.89, CI: 1.27-11.88). In view of these findings, the presence of respiratory diseases seems to be an important risk factor for a low QOL among elderly nursing home residents. PMID:26965222

  16. Levocloperastine in the treatment of chronic nonproductive cough: comparative efficacy versus standard antitussive agents.

    Science.gov (United States)

    Aliprandi, P; Castelli, C; Bernorio, S; Dell'Abate, E; Carrara, M

    2004-01-01

    The medical and social impact of cough is substantial. Current antitussive agents at effective doses have adverse events such as drowsiness, nausea and constipation that limit their use. There is also recent evidence that standard antitussive agents, such as codeine, may not reduce cough during upper respiratory infections. Therefore, there is a need for more effective and better-tolerated agents. The efficacy of levocloperastine, a novel antitussive, which acts both centrally on the cough center and on peripheral receptors in the tracheobronchial tree in treating chronic cough, was compared with that of other standard antitussive agents (codeine, levodropropizine and DL-cloperastine) in six open clinical trials. The studies enrolled patients of all ages with cough associated with various respiratory disorders including bronchitis, asthma, pneumonia and chronic obstructive pulmonary disease. Levocloperastine significantly improved cough symptoms (intensity and frequency of cough) in all trials, and improvements were observed after the first day of treatment. In children, levocloperastine reduced nighttime awakenings and irritability, and in adults it was effective in treating cough induced by angiotensin-converting enzyme inhibitors. When compared with other antitussive agents, levocloperastine had improved or comparable efficacy, with a more rapid onset of action. Importantly, no evidence of central adverse events was recorded with levocloperastine, whereas drowsiness was reported by a significant number of patients receiving codeine. Levocloperastine is an effective antitussive agent for the treatment of cough in patients of all ages. It has a more rapid onset of action than standard agents with an improved tolerability profile. PMID:15553659

  17. Managing your chronic pain

    Science.gov (United States)

    ... your chronic back pain To use the sharing features on this page, please enable JavaScript. Managing chronic pain means finding ways to make your back pain tolerable so you can live your life. You may not be able to ...

  18. Chronic diseases in adolescence

    Directory of Open Access Journals (Sweden)

    Rončević Nevenka

    2006-01-01

    Full Text Available Introduction. The prevalence of chronic diseases in adolescence is constantly increasing, especially in the last two decades. Adolescence is a period of important changes: body growth and development, sexual development, development of cognitive abilities, change in family relations and between peers, formation of personal identity and personal system of values, making decisions on future occupation etc. Chronic diseases in adolescence. Chronic disorders affect all development issues and represent an additional burden for adolescents. The interaction between chronic disorders and various development issues is complex and two-way: the disease may affect development, and development may affect the disease. Developmental, psychosocial and family factors are of great importance in the treatment of adolescents with chronic disorders. Chronic disorders affect all aspects of adolescent life, including relations with peers, school, nutrition, learning, traveling, entertainment, choice of occupation, plans for the future. Physicians should keep in mind that chronic diseases and their treatment represent only one aspect of person's life. Adolescents with chronic diseases have other needs as well, personal priorities, social roles and they expect these needs to be recognized and respected. Adolescent health care should be adjusted to the life style of adolescents.

  19. The Chronic Responsibility

    DEFF Research Database (Denmark)

    Ravn, Iben M; Frederiksen, Kirsten; Beedholm, Kirsten

    2016-01-01

    This article reports on the results of a Fairclough-inspired critical discourse analysis aiming to clarify how chronically ill patients are presented in contemporary Danish chronic care policies. Drawing on Fairclough’s three-dimensional framework for analyzing discourse, and using Dean’s concepts...... of governmentality as an interpretative lens, we analyzed and explained six policies published by the Danish Health and Medicines Authority between 2005 and 2013. The analysis revealed that discourses within the policy vision of chronic care consider chronically ill patients’ active role, lifestyle......, and health behavior to be the main factors influencing susceptibility to chronic diseases. We argue that this discursive construction naturalizes a division between people who can actively manage responsible self-care and those who cannot. Such discourses may serve the interests of those patients who...

  20. [Chronic migraine: treatment].

    Science.gov (United States)

    Pascual, Julio

    2012-04-10

    We define chronic migraine as that clinical situation in which migraine attacks appear 15 or more days per month. Until recently, and in spite of its negative impact, patients with chronic migraine were excluded of the clinical trials. This manuscript revises the current treatment of chronic migraine. The first step should include the avoidance of potential precipitating/aggravating factors for chronic migraine, mainly analgesic overuse and the treatment of comorbid disorders, such as anxiety and depression. The symptomatic treatment should be based on the use of nonsteroidal anti-inflammatory agents and triptans (in this case ergotamine-containing medications. Preventive treatment includes a 'transitional' treatment with nonsteroidal anti-inflammatory agents or steroids, while preventive treatment exerts its actions. Even though those medications efficacious in episodic migraine prevention are used, the only drugs with demonstrated efficacy in the preventive treatment of chronic migraine are topiramate and pericranial infiltrations of Onabotulinumtoxin A. PMID:22532241

  1. The Yanhuning injection in the treatment of acute bronchitis effect observed%炎琥宁注射液治疗急性支气管炎的效果观察

    Institute of Scientific and Technical Information of China (English)

    李瑛

    2012-01-01

      Objective Used in acute bronchitis Yanhuning injection effect for study. Methods Random selection in our hospital from June 2010 to June 2012 79 patients with acute bronchitis, divided into A and B group, A group of 45 patients for the treatment group, B group 34 patients of the control group were given Yanhuning injectionfluids and amoxicilin healing.Results A group of patients after treatment, fever, and other symptoms of wheezing and wheezing disappeared improve less than group B patients, treatment efficiency than in group B, the incidence of adverse reactions was significantly lower than that in group B patients.Conclusion Yanhuning injection used in acute bronchitis, a faster recovery of the patient's condition, there are more efficient.%  目的对炎琥宁注射液应用于急性支气管炎的效果加以研究分析。方法随机选择我院2010年6月-2012年6月急性支气管炎患者79名,分成A、B组,A组45名患者为治疗组,B组34名患者为对照组,分别给予炎琥宁注射液和阿莫西林医治。结果经治疗,A组患者发热、喘憋以及喘鸣音消失等病症改善时间均少于B组患者,治疗有效率高于B组,不良反应发生率明显低于B组患者。结论炎琥宁注射液应用于急性支气管炎,患者病症恢复较快,有效率较高。

  2. Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

    Science.gov (United States)

    ... People About NINDS NINDS Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Information Page Table of Contents (click to jump ... en Español What is Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)? Chronic inflammatory demyelinating polyneuropathy (CIDP) is a neurological ...

  3. Stages of Chronic Myelogenous Leukemia

    Science.gov (United States)

    ... ALL Treatment Childhood AML Treatment Research Chronic Myelogenous Leukemia Treatment (PDQ®)–Patient Version General Information About Chronic Myelogenous Leukemia Go to Health Professional Version Key Points Chronic ...

  4. Stages of Chronic Lymphocytic Leukemia

    Science.gov (United States)

    ... ALL Treatment Childhood AML Treatment Research Chronic Lymphocytic Leukemia Treatment (PDQ®)–Patient Version General Information About Chronic Lymphocytic Leukemia Go to Health Professional Version Key Points Chronic ...

  5. Influence of sex on chronic obstructive pulmonary disease risk and treatment outcomes

    Directory of Open Access Journals (Sweden)

    Aryal S

    2014-10-01

    Full Text Available Shambhu Aryal,1 Enrique Diaz-Guzman,2 David M Mannino3 1Division of Pulmonary, Allergy and Critical Care Medicine, Duke University, Durham, NC, 2Division of Pulmonary, Allergy and Critical Care, University of Alabama, Birmingham, AL, 3Department of Preventive Medicine and Environmental Health, University of Kentucky, Lexington, KY, USA Abstract: Chronic obstructive pulmonary disease (COPD, one of the most common chronic diseases and a leading cause of death, has historically been considered a disease of men. However, there has been a rapid increase in the prevalence, morbidity, and mortality of COPD in women over the last two decades. This has largely been attributed to historical increases in tobacco consumption among women. But the influence of sex on COPD is complex and involves several other factors, including differential susceptibility to the effects of tobacco, anatomic, hormonal, and behavioral differences, and differential response to therapy. Interestingly, nonsmokers with COPD are more likely to be women. In addition, women with COPD are more likely to have a chronic bronchitis phenotype, suffer from less cardiovascular comorbidity, have more concomitant depression and osteoporosis, and have a better outcome with acute exacerbations. Women historically have had lower mortality with COPD, but this is changing as well. There are also differences in how men and women respond to different therapies. Despite the changing face of COPD, care providers continue to harbor a sex bias, leading to underdiagnosis and delayed diagnosis of COPD in women. In this review, we present the current knowledge on the influence of sex on COPD risk factors, epidemiology, diagnosis, comorbidities, treatment, and outcomes, and how this knowledge may be applied to improve clinical practices and advance research. Keywords: chronic obstructive lung disease, sex, smoking, comorbidity, sex bias

  6. 加减桑菊饮治疗支气管炎24例疗效观察%Clinical observation on treating 24 cases of bronchitis by the Sangju decoction

    Institute of Scientific and Technical Information of China (English)

    佘佑林

    2013-01-01

      目的:探讨中药组方桑菊饮的加减治疗支气管炎的临床疗效,以期为临床用药提供数据支持。方法:将我院于2011年6月~2012年6月间收治的48例支气管炎患者随机分为两组,每组24例患者,实验组根据中医辨证论治的原则给予加减桑菊饮治疗;对照组则采用急支糖浆进行治疗,治疗7d后对比两组疗效。结果:经治疗后,实验组患者总有效率为83.3%;对照组为66.7%,实验组疗效显著优于对照组(x2=4.763,P<0.05)。结论:根据中医辨证论治的原则采用加减桑菊饮治疗支气管炎疗效显著,值得进行临床推广。%Objective:To investigate the clinical efficacy of TCD Sangju decoction in treating bronchitis, to provide data support for the clinical use of drugs. Methods:48 cases of bronchitis patients admitted to our hospital from June 2011 to June 2012 were randomly divided into two groups, 24 cases in each group. Experimental group was given addition and subtraction of Sangju decoction according to the principles of TCM;the control group received the treatment of acute bronchitis syrup, after 7 days treatment, comparing the clinical effect of the two groups. Results: The total efficiency of the treatment group was 83.3%, and 66.7% in the control group. There was a significant difference (P<0.05) in two groups. Conclusion:The treatment of bronchitis with addition and subtraction of SangJu decoction which is according to the principles of TCM obtained a significant clinical effects.

  7. Analysis of similarity of the SI gene in infectious bronchitis virus (IBV) isolates in Shanghai, China Análisis de similaridad del gen S1 de aislados del virus de la bronquitis infecciosa (IBV) en Shanghai, China

    OpenAIRE

    Zhu, J. G.; H D Qian; Y. L. Zhang; Hua, X.G.; ZL, Wu

    2007-01-01

    The aim of the study was to analyze the similarity of the SI gene in 5 novel viral strains of infectious bronchitis virus (IBV) isolated in Shanghai, China, using a pair of specific primers which were designed based on the published sequences of the S gene of IBV. The 5 full-length cDNA segments of the SI gene were amplified from the 5 isolated strains with RT-PCR. It was confirmed that the nucleotide sequences of the SI gene in the 5 strains isolated from chickens and pigeon have a length of...

  8. Using Health Utility Index (HUI for Measuring the Impact on Health-Related Quality of Life (HRQL Among Individuals with Chronic Diseases

    Directory of Open Access Journals (Sweden)

    Frank Mo

    2004-01-01

    Full Text Available Quality of life is an important indicator in assessing the burden of disease, especially for chronic conditions. The Health Utilities Index (HUI is a recently developed system for measuring the overall health status and health-related quality of life (HRQL of individuals, clinical groups, and general populations. Using the HUI (constructed based on eight attributes: vision, hearing, speech, mobility, dexterity, cognition, emotion, and pain/discomfort to measure the HRQL for chronic disease patients and to detect possible associations between HUI system and various chronic conditions, this study provides information to improve the management of chronic diseases.This study is of interest to data analysts, policy makers, and public health practitioners involved in descriptive clinical studies, clinical trials, program evaluation, population health planning, and assessments. Based on the Canadian Community Health Survey (CCHS for 2000–01, the HUI was used to measure the quality of life for individuals living with various chronic conditions (Alzheimer/other dementia, effects of stroke, urinary incontinence, arthritis/rheumatism, bowel disorder, cataracts, back problems, stomach/intestinal ulcers, emphysema/COPD, chronic bronchitis, epilepsy, heart disease, diabetes, migraine headaches, glaucoma, asthma, fibromyalgia, cancers, high blood pressure, multiple sclerosis, thyroid condition, and other remaining chronic diseases. Logistic Regression Model was employed to estimate the associations between the overall HUI scores and various chronic conditions. The HUI scores ranged from 0.00 (corresponding to a state close to death to 1.00 (corresponding to perfect health; negative scores reflect health states considered worse than death. The mean HUI score by sex and age group indicated the typical quality of life for persons with various chronic conditions. Logistic Regression results showed a strong relationship between low HUI scores (≤ 0.5 and 0.06

  9. Chronicity and control

    DEFF Research Database (Denmark)

    Whyte, Susan Reynolds

    2012-01-01

    This paper proposes a way of framing the study of ‘noncommunicable diseases’ within the more general area of chronic conditions. Focusing on Africa, it takes as points of departure the situation in Uganda, and the approach to health issues developed by a group of European and African colleagues...... over the years. It suggests a pragmatic analysis that places people's perceptions and practices within a field of possibilities shaped by policy, health care systems, and life conditions. In this field, the dimensions of chronicity and control are the distinctive analytical issues. They lead on to...... consideration of patterns of sociality related to chronic conditions and their treatment....

  10. Chronic Conditions Dashboard

    Data.gov (United States)

    U.S. Department of Health & Human Services — The CMS Chronic Conditions Dashboard presents statistical views of information on the prevalence, utilization and Medicare spending for Medicare beneficiaries with...

  11. Anemia of chronic disease

    Science.gov (United States)

    Anemia of inflammation; AOCD; ACD ... Anemia is a lower-than-normal number of red blood cells in the blood. Some conditions can lead to anemia of chronic disease include: Autoimmune disorders , such as ...

  12. What Is Chronic Pain?

    Medline Plus

    Full Text Available Already a member? Log In or Sign Up Home About Us Support the ACPA Contact Us Shop ... for Understanding Pain September is Pain Awareness Month Home Pain Management Tools Videos What Is Chronic Pain? ...

  13. Sleep and Chronic Disease

    Science.gov (United States)

    ... message, please visit this page: About CDC.gov . Sleep About Us About Sleep Key Sleep Disorders Sleep ... Sheets Data & Statistics Projects and Partners Resources Events Sleep and Chronic Disease Recommend on Facebook Tweet Share ...

  14. What Is Chronic Pain?

    Medline Plus

    Full Text Available ... after a period of time the spinal cord has changed, after a period of time there are ... absence of an apparent cause. But chronic pain has a physiological or neurological basis even when we ...

  15. What Is Chronic Pain?

    Medline Plus

    Full Text Available ... acute pain and both naturally expect that some cause will be found, and when it’s found, it ... pain even in the absence of an apparent cause. But chronic pain has a physiological or neurological ...

  16. Chronic rhinosinusitis pathogenesis.

    Science.gov (United States)

    Stevens, Whitney W; Lee, Robert J; Schleimer, Robert P; Cohen, Noam A

    2015-12-01

    There are a variety of medical conditions associated with chronic sinonasal inflammation, including chronic rhinosinusitis (CRS) and cystic fibrosis. In particular, CRS can be divided into 2 major subgroups based on whether nasal polyps are present or absent. Unfortunately, clinical treatment strategies for patients with chronic sinonasal inflammation are limited, in part because the underlying mechanisms contributing to disease pathology are heterogeneous and not entirely known. It is hypothesized that alterations in mucociliary clearance, abnormalities in the sinonasal epithelial cell barrier, and tissue remodeling all contribute to the chronic inflammatory and tissue-deforming processes characteristic of CRS. Additionally, the host innate and adaptive immune responses are also significantly activated and might be involved in pathogenesis. Recent advancements in the understanding of CRS pathogenesis are highlighted in this review, with special focus placed on the roles of epithelial cells and the host immune response in patients with cystic fibrosis, CRS without nasal polyps, or CRS with nasal polyps. PMID:26654193

  17. Chronic Hypertension in Pregnancy

    Science.gov (United States)

    ... very commonly used to treat chronic hypertension. This drug class can cause problems in the fetus, in- cluding an increased risk of birth de- fects 4 and kidney failure. Angiotensin II receptor blockers also should be avoided ...

  18. Chronic Conditions PUF

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Chronic Conditions PUFs are aggregated files in which each record is a profile or cell defined by the characteristics of Medicare beneficiaries. A profile is...

  19. What Is Chronic Pain?

    Medline Plus

    Full Text Available ... ACPA Contact Us Shop FAQs The Art of Pain Management Resources Going to the ER Glossary Surveys What We Have Learned Communication Tools Videos Pain Management Programs Resource Guide to Chronic Pain Treatments Pain ...

  20. Chronic penile strangulation

    Directory of Open Access Journals (Sweden)

    Lopes Roberto I

    2003-01-01

    Full Text Available Chronic penile strangulation is exceedingly rare with only 5 cases previously reported. We report an additional case of progressive penile lymphedema due to chronic intermittent strangulation caused by a rubber band applied to the penile base for 6 years. A 49-year-old man presented incapacity to exteriorize the glans penis. For erotic purposes, he had been using a rubber-enlarging band placed in the penile base for 6 years. With chronic use, he noticed that his penis swelled. Physical examination revealed lymphedema of the penis, phimosis and a stricture in the penile base. The patient was submitted to circumcision and the lymphedema remained stable 10 months postoperatively. Chronic penile incarceration usually causes penile lymphedema and urinary disturbance. Treatment consists of removal of foreign devices and surgical treatment of lymphedema.

  1. Neuromodulation of chronic headaches

    DEFF Research Database (Denmark)

    Martelletti, Paolo; Jensen, Rigmor H; Antal, Andrea;

    2013-01-01

    The medical treatment of patients with chronic primary headache syndromes (chronic migraine, chronic tension-type headache, chronic cluster headache, hemicrania continua) is challenging as serious side effects frequently complicate the course of medical treatment and some patients may be even...... medically intractable. When a definitive lack of responsiveness to conservative treatments is ascertained and medication overuse headache is excluded, neuromodulation options can be considered in selected cases.Here, the various invasive and non-invasive approaches, such as hypothalamic deep brain...... proper RCT-based evidence is limited. The European Headache Federation herewith provides a consensus statement on the clinical use of neuromodulation in headache, based on theoretical background, clinical data, and side effect of each method. This international consensus further gives recommendations for...

  2. What Is Chronic Pain?

    Medline Plus

    Full Text Available ... Contact Us Shop FAQs The Art of Pain Management Resources Going to the ER Glossary Surveys What We Have Learned Communication Tools Videos Pain Management Programs Resource Guide to Chronic Pain Treatments Pain ...

  3. Chronic Conditions Chartbook

    Data.gov (United States)

    U.S. Department of Health & Human Services — Chronic Conditions among Medicare Beneficiaries is a chartbook prepared by the Centers for Medicare and Medicaid Services and created to provide an overview of...

  4. What Is Chronic Pain?

    Medline Plus

    Full Text Available ... Programs Resource Guide to Chronic Pain Treatments Pain Awareness Toolkits Partners for Understanding Pain September is Pain Awareness Month Home Pain Management Tools Videos What Is ...

  5. What Is Chronic Pain?

    Medline Plus

    Full Text Available ... chronic pain there may be no apparent physical injury or illness to explain it. The physician and ... expected period of healing for an illness or injury. You can experience pain even if you are ...

  6. Chronic Condition Data Warehouse

    Data.gov (United States)

    U.S. Department of Health & Human Services — The CMS Chronic Condition Data Warehouse (CCW) provides researchers with Medicare and Medicaid beneficiary, claims, and assessment data linked by beneficiary across...

  7. Chronic Fatigue Syndrome

    Science.gov (United States)

    Chronic fatigue syndrome (CFS) is a disorder that causes extreme fatigue. This fatigue is not the kind of tired feeling that ... activities. The main symptom of CFS is severe fatigue that lasts for 6 months or more. You ...

  8. Chronic dysimmune neuropathies: Beyond chronic demyelinating polyradiculoneuropathy

    Directory of Open Access Journals (Sweden)

    Khadilkar Satish

    2011-01-01

    Full Text Available The spectrum of chronic dysimmune neuropathies has widened well beyond chronic demyelinating polyradiculoneuropathy (CIDP. Pure motor (multifocal motor neuropathy, sensorimotor with asymmetrical involvement (multifocal acquired demylinating sensory and motor neuropathy, exclusively distal sensory (distal acquired demyelinating sensory neuropathy and very proximal sensory (chronic immune sensory polyradiculopathy constitute the variants of CIDP. Correct diagnosis of these entities is of importance in terms of initiation of appropriate therapy as well as prognostication of these patients. The rates of detection of immune-mediated neuropathies with monoclonal cell proliferation (monoclonal gammopathy of unknown significance, multiple myeloma, etc. have been facilitated as better diagnostic tools such as serum immunofixation electrophoresis are being used more often. Immune neuropathies associated with malignancies and systemic vasculitic disorders are being defined further and treated early with better understanding of the disease processes. As this field of dysimmune neuropathies will evolve in the future, some of the curious aspects of the clinical presentations and response patterns to different immunosuppressants or immunomodulators will be further elucidated. This review also discusses representative case studies.

  9. Protection induced by infectious laryngotracheitis virus vaccines alone and combined with Newcastle disease virus and/or infectious bronchitis virus vaccines.

    Science.gov (United States)

    Vagnozzi, Ariel; García, Maricarmen; Riblet, Sylva M; Zavala, Guillermo

    2010-12-01

    Two types of live attenuated vaccines have been used worldwide for the control of infectious laryngotracheitis virus (ILTV): 1) chicken embryo origin (CEO) vaccines; and 2) tissue culture origin vaccines (TCO). However, the disease persists in spite of extensive use of vaccination, particularly in areas of intense broiler production. Among the factors that may influence the efficiency of ILTV live attenuated vaccines is a possible interference of Newcastle Disease virus (NDV) and infectious bronchitis virus (IBV) vaccines with the protection induced by ILTV vaccines. The protection induced by CEO and TCO vaccines was evaluated when administered at 14 days of age alone or in combination with the B1 type strain of NDV (B1) and/or the Arkansas (ARK) and Massachusetts (MASS) serotypes of IBV vaccines. Two weeks after vaccination (28 days of age), the chickens were challenged with a virulent ILTV field strain (63140 isolate, group V genotype). Protection was evaluated at 5 and 7 days postchallenge by scoring clinical signs and quantifying the challenge virus load in the trachea using real-time PCR (qPCR). In addition, the viral load of the vaccine viruses (ILTV, NDV, and IBV) was quantified 3 and 5 days postvaccination also using qPCR. The results of this study indicate that the NDV (B1) and IBV (ARK) vaccines and a multivalent vaccine constituted by NDV (B1) and IBV (ARK and MASS) did not interfere with the protection induced by the CEO ILTV vaccine. However, the NDV (BI) and the multivalent (B1/MASS/ARK) vaccines interfered with the protection induced by the TCO vaccine (P vaccines decreased the tracheal replication of the TCO vaccine and the protection induced by this vaccine, since the ILTV-vaccinated and -challenged chickens displayed significantly more severe clinical signs and ILTV load (P vaccinated with the TCO vaccine alone. Although NDV and IBV challenges were not performed, the antibody responses elicited by NDV and/or the IBV vaccinations were significantly

  10. Idiopathic chronic eosinophilic pneumonia

    OpenAIRE

    Cordier Jean-François; Marchand Eric

    2006-01-01

    Abstract Idiopathic chronic eosinophilic pneumonia (ICEP) is characterized by subacute or chronic respiratory and general symptoms, alveolar and/or blood eosinophilia, and peripheral pulmonary infiltrates on chest imaging. Eosinophilia is present in most cases, usually in excess of 1000/mm3. In absence of significant blood eosinophilia, a diagnosis of ICEP is supported by the demonstration of bronchoalveolar lavage eosinophilia. ICEP is typically associated with eosinophil counts higher than ...

  11. Chronic osteomyelitis mimicking sarcoma

    OpenAIRE

    Gulmann, C; Young, O.; Tolan, M.; O’Riordan, D.; Leader, M

    2003-01-01

    This report describes a rare case of chronic osteomyelitis in a 60 year old man mimicking a soft tissue sarcoma. Chronic osteomyelitis is an infrequent cause of a soft tissue mass and is usually diagnosed clinically by a combination of radiology and microbiology. Rarely, COM can mimic a primary bony neoplasm, but this is the first reported case where it mimicked a soft tissue sarcoma. The clinical, radiological, and histological appearances of this case will be discussed.

  12. Hypertension in Chronic Glomerulonephritis.

    Science.gov (United States)

    Ihm, Chun-Gyoo

    2015-12-01

    Chronic glomerulonephritis (GN), which includes focal segmental glomerulosclerosis and proliferative forms of GN such as IgA nephropathy, increases the risk of hypertension. Hypertension in chronic GN is primarily volume dependent, and this increase in blood volume is not related to the deterioration of renal function. Patients with chronic GN become salt sensitive as renal damage including arteriolosclerosis progresses and the consequent renal ischemia causes the stimulation of the intrarenal renin-angiotensin-aldosterone system(RAAS). Overactivity of the sympathetic nervous system also contributes to hypertension in chronic GN. According to the KDIGO guideline, the available evidence indicates that the target BP should be ≤140mmHg systolic and ≤90mmHg diastolic in chronic kidney disease patients without albuminuria. In most patients with an albumin excretion rate of ≥30mg/24 h (i.e., those with both micro-and macroalbuminuria), a lower target of ≤130mmHg systolic and ≤80mmHg diastolic is suggested. The use of agents that block the RAAS system is recommended or suggested in all patients with an albumin excretion rate of ≥30mg/ 24 h. The combination of a RAAS blockade with a calcium channel blocker and a diuretic may be effective in attaining the target BP, and in reducing the amount of urinary protein excretion in patients with chronic GN. PMID:26848302

  13. Karakteristik Penderita Bronkitis Yang Dirawat Jalan Pada Kelompok Umur > 15 Tahun Di RSU Dr. Ferdinand Lumban Tobing Sibolga Tahun 2010 - 2012

    OpenAIRE

    Simanjuntak, Rinaldi Togap

    2014-01-01

    Bronchitis (Inflamation bronchi) is described as inflammation of the bronchial vessels. It is characterized by inflammation of the bronchial tubes and divided into acute and chronic forms. Indonesia does not have accurate data on morbidity of acute or chronic bronchitis. Bronchitis including ten biggest disease in the outpatient Dr. Ferdinan L. Tobing General Hospital. Total cases of bronchitis in 2010-2012 there were 442 cases. To determine the characteristics of patients with bronchitis ...

  14. Expression profiles of hydrophobic surfactant proteins in children with diffuse chronic lung disease

    Directory of Open Access Journals (Sweden)

    Guttentag Susan

    2005-07-01

    Full Text Available Abstract Background Abnormalities of the intracellular metabolism of the hydrophobic surfactant proteins SP-B and SP-C and their precursors may be causally linked to chronic childhood diffuse lung diseases. The profile of these proteins in the alveolar space is unknown in such subjects. Methods We analyzed bronchoalveolar lavage fluid by Western blotting for SP-B, SP-C and their proforms in children with pulmonary alveolar proteinosis (PAP, n = 15, children with no SP-B (n = 6, children with chronic respiratory distress of unknown cause (cRD, n = 7, in comparison to children without lung disease (n = 15 or chronic obstructive bronchitis (n = 19. Results Pro-SP-B of 25–26 kD was commonly abundant in all groups of subjects, suggesting that their presence is not of diagnostic value for processing defects. In contrast, pro-SP-B peptides cleaved off during intracellular processing of SP-B and smaller than 19–21 kD, were exclusively found in PAP and cRD. In 4 of 6 children with no SP-B, mutations of SFTPB or SPTPC genes were found. Pro-SP-C forms were identified at very low frequency. Their presence was clearly, but not exclusively associated with mutations of the SFTPB and SPTPC genes, impeding their usage as candidates for diagnostic screening. Conclusion Immuno-analysis of the hydrophobic surfactant proteins and their precursor forms in bronchoalveolar lavage is minimally invasive and can give valuable clues for the involvement of processing abnormalities in pediatric pulmonary disorders.

  15. Chronic Airflow Obstruction in a Black African Population: Results of BOLD Study, Ile-Ife, Nigeria.

    Science.gov (United States)

    Obaseki, Daniel O; Erhabor, Gregory E; Gnatiuc, Louisa; Adewole, Olufemi O; Buist, Sonia A; Burney, Peter G

    2016-01-01

    Global estimates suggest that Chronic Obstructive Pulmonary Disease (COPD) is emerging as a leading cause of death in developing countries but there are few spirometry-based general population data on its prevalence and risk factors in sub-Saharan Africa. We used the Burden of Obstructive Lung Disease (BOLD) protocol to select a representative sample of adults aged 40 years and above in Ile-Ife, Nigeria. All the participants underwent spirometry and provided information on smoking history, biomass and occupational exposures as well as diagnosed respiratory diseases and symptoms. Chronic Airflow Obstruction (CAO) was defined as the ratio of post-bronchodilator (BD) one second Forced Expiratory Volume (FEV1) to Forced Vital Capacity (FVC) below the lower limit of normal (LLN) of the population distribution for FEV1/FVC. The overall prevalence of obstruction (post-BD FEV1/FVC < LLN) was 7.7% (2.7% above LLN) using Global Lung Function Initiative (GLI) equations. It was associated with few respiratory symptoms; 0.3% reported a previous doctor-diagnosed chronic bronchitis, emphysema or COPD. Independent predictors included a lack of education (OR 2.5, 95% CI: 1.0, 6.4) and a diagnosis of either TB (OR 23.4, 95% CI: 2.0, 278.6) or asthma (OR 35.4, 95%CI: 4.9, 255.8). There was no association with the use of firewood or coal for cooking or heating. The vast majority of this population (89%) are never smokers. We conclude that the prevalence of CAO is low in Ile-Ife, Nigeria and unrelated to biomass exposure. The key independent predictors are poor education, and previous diagnosis of tuberculosis or asthma. PMID:26451840

  16. Time to First Morning Cigarette and Risk of Chronic Obstructive Pulmonary Disease: Smokers in the PLCO Cancer Screening Trial.

    Directory of Open Access Journals (Sweden)

    Kristin A Guertin

    Full Text Available Time to first cigarette (TTFC after waking is an indicator of nicotine dependence. The association between TTFC and chronic obstructive pulmonary disease (COPD, the third leading cause of death in the United States, has not yet been reported.We investigated the cross-sectional association between TTFC and prevalent COPD among 6,108 current smokers in the Prostate, Lung, Colorectal, and Ovarian (PLCO Cancer Screening Trial. COPD was defined as a self-reported diagnosis of emphysema, chronic bronchitis, or both. Current smokers in PLCO reported TTFC, the amount of time they typically waited before smoking their first cigarette of the day after waking, in four categories: ≤ 5, 6-30, 31-60, or > 60 minutes. We used logistic regression models to investigate the association between TTFC and prevalent COPD with adjustments for age, gender, race, education, and smoking (cigarettes/day, years smoked during lifetime, pack-years, age at smoking initiation, and prior lung cancer diagnosis.COPD was reported by 19% of these 6,108 smokers. Individuals with the shortest TTFC had the greatest risk of COPD; compared to those with the longest TTFC (> 60 minutes the adjusted odds ratios (OR and 95% confidence intervals (CI for COPD were 1.48 (95% CI, 1.15-1.91, 1.64 (95% CI, 1.29-2.08, 2.18 (95% CI, 1.65-2.87 for those with TTFC 31-60 minutes, 6-30 minutes, and ≤ 5 minutes, respectively (P-trend 60 minutes, the adjusted OR (95% CI was 2.29 (1.69-3.12 for emphysema and 2.99 (1.95-4.59 for chronic bronchitis.Current smokers with shorter TTFC have increased risk of COPD compared to those with longer TTFC, even after comprehensive adjustment for established smoking covariates. Future epidemiologic studies, including prospective designs, should incorporate TTFC to better assess disease risk and evaluate the potential utility of TTFC as a COPD screening tool for smokers in the clinical setting.

  17. Chronic daily headaches

    Directory of Open Access Journals (Sweden)

    Fayyaz Ahmed

    2012-01-01

    Full Text Available Chronic Daily Headache is a descriptive term that includes disorders with headaches on more days than not and affects 4% of the general population. The condition has a debilitating effect on individuals and society through direct cost to healthcare and indirectly to the economy in general. To successfully manage chronic daily headache syndromes it is important to exclude secondary causes with comprehensive history and relevant investigations; identify risk factors that predict its development and recognise its sub-types to appropriately manage the condition. Chronic migraine, chronic tension-type headache, new daily persistent headache and medication overuse headache accounts for the vast majority of chronic daily headaches. The scope of this article is to review the primary headache disorders. Secondary headaches are not discussed except medication overuse headache that often accompanies primary headache disorders. The article critically reviews the literature on the current understanding of daily headache disorders focusing in particular on recent developments in the treatment of frequent headaches.

  18. Management of chronic paronychia

    Directory of Open Access Journals (Sweden)

    Vineet Relhan

    2014-01-01

    Full Text Available Chronic paronychia is an inflammatory disorder of the nail folds of a toe or finger presenting as redness, tenderness, and swelling. It is recalcitrant dermatoses seen commonly in housewives and housemaids. It is a multifactorial inflammatory reaction of the proximal nail fold to irritants and allergens. Repeated bouts of inflammation lead to fibrosis of proximal nail fold with poor generation of cuticle, which in turn exposes the nail further to irritants and allergens. Thus, general preventive measures form cornerstone of the therapy. Though previously anti-fungals were the mainstay of therapy, topical steroid creams have been found to be more effective in the treatment of chronic paronychia. In recalcitrant cases, surgical treatment may be resorted to, which includes en bloc excision of the proximal nail fold or an eponychial marsupialization, with or without nail plate removal. Newer therapies and surgical modalities are being employed in the management of chronic paronychia. In this overview, we review recent epidemiological studies, present current thinking on the pathophysiology leading to chronic paronychia, discuss the challenges chronic paronychia presents, and recommend a commonsense approach to management.

  19. Lactoferrin in Chronic Pancreatitis

    Directory of Open Access Journals (Sweden)

    Chun Xiang Jin

    2009-05-01

    Full Text Available The present review is focused on the clinical significance of lactoferrin in pancreatic secretions and stone formation in chronic pancreatitis, and of serum anti-lactoferrin antibody in autoimmune pancreatitis. Lactoferrin secretion is increased in pancreatic secretions in calcified and non-calcified chronic pancreatitis. Lactoferrin, pancreatic stone protein and trypsin are present in pancreatic stones. We cannot conclude which protein is more important for the precipitate and stone formation. The presence of antilactoferrin antibody has been reported in serum in autoimmune diseases, such as autoimmune pancreatitis. The coincidental appearance of autoimmune pancreatitis with extrapancreatic autoimmune diseases strongly suggests a common autoimmune mechanism and lactoferrin is a candidate antigen. Lactoferrin may play an important role as a precipitate protein in pancreatic stone formation in chronic pancreatitis and as an autoantigen in autoimmune pancreatitis. Further studies are required to better understand the role of lactoferin.

  20. Chronic urticaria: recent advances.

    Science.gov (United States)

    Greaves, Malcolm W; Tan, Kian Teo

    2007-10-01

    Chronic urticaria is an umbrella term, which encompasses physical urticarias, chronic "idiopathic" urticaria and urticarial vasculitis. It is important to recognize patients with physical urticarias as the investigation and treatment differs in important ways from patients with idiopathic chronic urticaria or urticarial vasculitis. Although relatively uncommon, urticarial vasculitis is an important diagnosis to make and requires histological confirmation by biopsy. Underlying systemic disease and systemic involvement, especially of the kidneys, should be sought. It is now recognized that chronic "idiopathic" urticaria includes a subset with an autoimmune basis caused by circulating autoantibodies against the high affinity IgE receptor (FceR1) and less commonly against IgE. Although the autologous serum skin test has been proven useful in prompting search for and characterization of circulating wheal-producing factors in chronic urticaria, its specificity as a screening test for presence of functional anti-FceR1 is low, and confirmation by demonstration of histamine-releasing activity in the patient's serum must be the benchmark test in establishing this diagnosis. Improved screening tests are being sought; for example, ability of the chronic urticaria patient's serum to evoke expression of CD 203c on donor human basophils is showing some promise. The strong association between autoimmune thyroid disease and autoimmune urticaria is also an area of ongoing research. Drug treatment continues to be centered on the H1 antihistamines, and the newer second-generation compounds appear to be safe and effective even in off-label dosage. Use of systemic steroids should be confined to special circumstances such as tapering regimens for acute flare-ups. Use of leukotriene antagonists is becoming popular, but the evidence for efficacy is conflicting. Cyclosporin is also effective and can be used in selected cases of autoimmune urticaria, and it is also effective in non

  1. Omalizumab for chronic urticaria

    DEFF Research Database (Denmark)

    Ivyanskiy, Ilya; Sand, Carsten; Thomsen, Simon Francis

    2012-01-01

    urticaria. We present a case series of 19 patients with chronic urticaria treated in a university department with omalizumab and give an overview of the existing literature comprising an additional 59 cases as well as a total of 139 patients enrolled in two randomized controlled trials comparing omalizumab......Omalizumab is a recombinant humanized monoclonal antibody that blocks the high-affinity Fc receptor of IgE. Omalizumab has been approved for the treatment of moderate to severe asthma; however, there is currently more and more data showing promising results in the management also of chronic...

  2. Chronic lead poisoning

    Energy Technology Data Exchange (ETDEWEB)

    Hess, K.; Straub, P.W.

    1974-02-19

    A detailed description is given of the complex pathological picture observed in the case of a worker with 30 years' occupational exposure to lead in an accumulator factory (evolution of the disease, clinical findings, autopsy). In spite of a typical clinical picture, lead is not held responsible for the terminal encephalopathy, in view of the fact that Alzheimer's syndrome was discovered at autopsy. However, the neurovegetative asthenia and progressive kidney disease without hypertonia, but with uraemia, which preceded the encephalopathy are in all probability due to chronic lead poisoning. The article discusses the diagnosis and symptomatology of chronic lead poisoning, encephalopathy and kidney disease.

  3. Observation on the Effect of the Treatment of Children with Recurrent Asthma Bronchitis%孟鲁司特治疗儿童反复哮喘性支气管炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    侯萍萍

    2016-01-01

    Objective:To discuss effect of montelukast in treatment of children recurrent asthmatic bronchiti. Method:From January to June 2014,200 children with recurrent asthmatic bronchitis were selected as research objects and randomly divided into treatment group and control group. The treatment group was given montelukast,4 mg 1 time per night of oral treatment for 6 months. The control group received placebo treatment. To compare the therapeutic effect between the two groups. Result:During the period of 6 months treatment, breathing frequency of symptoms of the treatment group was less than that of the control group,wheezing onset of the respiration rate was lower,breathe course was shorter. The difference was statistically significant(P<0.05). Conclusion:Montelukast can prevent the happening of the repeated sexual bronchitis asthma children breathing, reduce breathing attack,shorten the breathing course.%目的:探讨孟鲁司特治疗儿童反复哮喘性支气管炎疗效。方法:选取本院2014年1-6月收治的200例反复哮喘性支气管炎患儿作为本次研究的对象,随机数字表法分为治疗组与对照组,治疗组给予孟鲁司特4 mg每晚1次口服,治疗6个月,对照组给予安慰剂治疗,观察两组患儿的治疗效果。结果:在治疗的6个月内,治疗组患儿喘息发作的次数较对照组减少,喘息发作时的平均呼吸次数较对照组降低,喘息发作的平均时间较对照组缩短,比较差异有统计学意义(P<0.05)。结论:孟鲁司特可预防反复哮喘性支气管炎患儿喘息的发生,减低喘息发作的次数,降低喘息发作程度,缩短喘息时间。

  4. 氨溴特罗治疗儿童急性支气管炎临床观察%Therapeutic Effect of Ambroxol and Clenbuterol Oral Solutions on Acute Bronchitis in Children

    Institute of Scientific and Technical Information of China (English)

    吴启富

    2012-01-01

    目的:探讨氨溴特罗口服液治疗儿童急性支气管炎的效果.方法:300例急性支气管炎患儿随机分成两组各150例.两组均在控制感染的基础上,治疗组口服氨溴特罗,对照组口服复方福尔可定,疗程5 d.观察两组临床疗效、不良反应和依从性.结果:治疗5 d后,治疗组总有效率(93.33%)明显高于对照组(84.67%),差异有统计学意义(P<0.05);咳嗽、痰量、痰黏稠度、喘息评分、不良反应发生率和依从性等方面比较,差异均有统计学意义(P<0.01或0.05).结论:氨溴特罗治疗急性支气管炎疗效显著,安全可靠,依从性好.%Objective: To evaluate the therapeutic effects of ambroxol and clenbuterol oral solutions on acute bronchitis in children. Method: Totally 300 cases with acute bronchitis were randomly divided into the treatment group ( 150 cases ) and the control group ( 150 cases). On the basis of anti-inflammatory therapy, ambroxol and clenbuterol oral solutions were given in the treatment group and pholcodine syrups were used in the control group for 5 days. The therapeutic effects, adverse reactions and compliance of the two groups were assessed. Result: After the treatment,the total effective rate of the treatment group( 93. 33% )was higher than that of the control group ( 84. 67% )( P<0. 05 ). The effects on cough,sputum volume,sputum viscosity and wheezing were much better in the treatment group than those in the control group( P<0. 01 ). There were significant statistic differences in the adverse reactions and compliance between the two groups( P<0. 05 ). Conclusion: Ambroxol and clenbuterol oral solutions are safe, convenient and highly effective in the treatment of acute bronchitis in children.

  5. Therapeutic Effect of Budesonide Inhalation on Acute Infectious Laryngitis and Bronchitis%布地奈德吸入治疗急性喉炎、喉气管支气管炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    韩明达

    2015-01-01

    目的:分析探讨布地奈德吸入治疗急性喉炎、喉气管支气管炎症的临床效果。方法选取88例患有急性喉炎、喉气管支气管炎的患者作为研究对象,将其随机分成对照组和观察组,每组44例患者。对照组患者采用地塞米松静脉注射进行治疗,观察者则采取布地奈德雾化吸入进行治疗;治疗结束后,对比两组患者的治疗效果。结果采取布地奈德雾化吸入治疗的观察组患者在治疗效果及症状缓解上明显优于对照组,P<0.05,差异具有统计学意义。结论采用布地奈德雾化吸入治疗急性喉炎、喉气管支气管炎具有显著的治疗效果,患者症状能够得到迅速恢复。%Objective To explore the clinical effect analysis of budesonide inhalation in the treatment of acute laryngitis, bronchitis disease. Methods 88 cases with acute laryngitis, bronchitis of children as the research object, and were randomly separated into the observation group and the control group, 44 cases in each group of patients. The control group was treated with intravenous dexamethasone treatment, observers take budesonide inhalation treatment,in the end of the treatment, compared two groups of patients with treatment effect.Results Take budesonide atomization inhalation treatment observation group patients in the treatment and remission of symptoms signiifcantly better than the control group,P<0.05,with significant difference.Conclusion Inhalation in the treatment of acute laryngitis, bronchitis has signiifcant therapeutic effect of budesonide in children with symptoms, can be quickly restored.

  6. Watercress Formula for Chicken Kidney Type Infectious Bronchitis%荆芥组方对鸡肾型传染性支气管炎防治效果观察

    Institute of Scientific and Technical Information of China (English)

    冯善祥

    2011-01-01

    We used the method of randomization and duplication of pathological model to do this research. In order to validate the effects of the compound preparation of Chinese traditional medicine to the avian infectious bronchitis, we divided the 2-week-old AA kreo-chicken into 8 groups (30 chicken for each group), including the investigational drug groups (which include the high dose group and the moderate dose group as well as the low dose group) and the following control groups: the control group of traditional Chinese medicine and the Western medicine group, the vaccine control group and the negative control group as well as the health control group. The chickens were artificially infected with infectious bronchitis virus (IBV) to observe the protection of the compound preparation of Chinese traditional medicine. The results indicated that the compound preparation of Chinese traditional medicine has a great protection to chicken infected by (IBV). Therefore, the compound preparation of Chinese traditional medicine can be used to the prevention and cure of avian infectious bronchitis.%本试验采取随机分组,病理模型复制的方法,试验中将14日龄AA肉雏鸡240只随机分为受试药物组(高、中、低3个剂量)、中药对照组、西药对照组、疫苗对照组、阴性对照组、健康对照组共8个组,每组30只,以验证中药荆芥组方对鸡肾型传染性支气管炎的效果.将试验鸡人T感染肾型传染性支气管炎病毒(IBV),观察中药组方对雏鸡保护作用.结果表明,本组方对肾型传染性支气管炎病毒感染雏鸡具有明显的保护作用,可以用于鸡肾型传染性支气管炎的预防和治疗.

  7. Chronic respiratory effect of narguileh smoking compared with cigarette smoking in women from the East Mediterranean region

    Directory of Open Access Journals (Sweden)

    Yousser Mohammad

    2008-10-01

    Full Text Available Yousser Mohammad, Mouna Kakah, Yasser MohammadDepartment of Internal Medicine, Tishreen University School of Medicine, Lattakia, SyriaAbstract: Narguileh is a water pipe. Narguileh smoking is a traditional pattern of smoking among Eastern Mediterranean women, publicly considered as a harmless entertainment. We performed a survey aimed at tracking chronic respiratory symptoms and alteration in respiratory functions in 77 female narguileh smokers, 77 cigarette smokers, and controls. A questionnaire about respiratory symptoms, quantity, and duration of smoking was completed by each woman, and a flow-volume loop was performed with all women. Women were then categorized in subgroups according to a cumulative smoking duration of over 5 years, and cumulative quantity of 50 kilograms smoked. We obtained 8 subgroups for quantity and 10 for duration. Results showed a higher proportion of chronic bronchitis in narguileh smokers compared with cigarette smokers for both quantity and duration (p value < 0.001, as well as quasi-permanent alteration in maximum mid-expiratory flow (MMEF 25%–75% in narguileh smokers compared with cigarette smokers (p value < 0.001. Forced expired volume in one second was more altered in cigarette smokers than in narguileh smokers (p value > 0.001. These results will help to raise health authority awareness that narguileh smoking is also dangerous for women.Keywords: sheesha, narguileh, narguile, COPD, MMEF, smoking in women

  8. HIGH-Resolution CT in Chronic Pulmonary Changes after Mustard Gas Exposure

    Energy Technology Data Exchange (ETDEWEB)

    Bagheri, M.H.; Mostafavi, S.H. [Shiraz Univ. of Medical Siences (Iran, Islamic Republic of). Dept. of Radiology; Hosseini, S.K. [Shiraz Univ. of Medical Siences (Iran, Islamic Republic of). Dept. of Internal Medicine; Alavi, S.A. [Medical Center for Chemical Warfare Victims Foundation, Shiraz (Iran, Islamic Republic of)

    2003-05-01

    Purpose: To identify the findings of high-resolution CT (HRCT) of the lung in patients with previous sulfur mustard gas exposure, and to correlate these findings with clinical and chest X-ray (CXR) results. Material and Methods: 50 consecutive patients were studied prospectively. The clinical data were recorded. Standard p.a. CXR and HRCT of the lung and spirometry were performed. The findings of CXR, HRCT and clinical and spirometry results were scored between 0 and 3 according to the severity of the findings. Results: HRCT abnormality was detected in all 50 patients (100%), while CXR was abnormal in 40 patients (80%). The most common HRCT findings was airway abnormalities (bronchial wall thickening in 100% of cases). Other important findings were suggestive of interstitial lung disease (ILD) (80%), bronchiectasis (26%), and emphysema (24%). A statistically significant correlation was found between the severity of clinical presentation and that of the HCTR scores in patients with bronchiectasis, bronchitis and ILD (p< 0.05), but not with severity scores of HRCT in patients with emphysema. No significant correlation was found between severity scores of CXR findings. HRCT evidence of bronchial wall thickening and with a lower frequency ILD were present despite normal CXR in 20% of the patients. Conclusion: The results of this study suggest that bronchial wall thickening, ILD and emphysema are common chronic pulmonary sequelae of sulfur mustard injury. HRCT of the chest should be considered as the imaging modality of choice in chemical war injury.

  9. HIGH-Resolution CT in Chronic Pulmonary Changes after Mustard Gas Exposure

    International Nuclear Information System (INIS)

    Purpose: To identify the findings of high-resolution CT (HRCT) of the lung in patients with previous sulfur mustard gas exposure, and to correlate these findings with clinical and chest X-ray (CXR) results. Material and Methods: 50 consecutive patients were studied prospectively. The clinical data were recorded. Standard p.a. CXR and HRCT of the lung and spirometry were performed. The findings of CXR, HRCT and clinical and spirometry results were scored between 0 and 3 according to the severity of the findings. Results: HRCT abnormality was detected in all 50 patients (100%), while CXR was abnormal in 40 patients (80%). The most common HRCT findings was airway abnormalities (bronchial wall thickening in 100% of cases). Other important findings were suggestive of interstitial lung disease (ILD) (80%), bronchiectasis (26%), and emphysema (24%). A statistically significant correlation was found between the severity of clinical presentation and that of the HCTR scores in patients with bronchiectasis, bronchitis and ILD (p< 0.05), but not with severity scores of HRCT in patients with emphysema. No significant correlation was found between severity scores of CXR findings. HRCT evidence of bronchial wall thickening and with a lower frequency ILD were present despite normal CXR in 20% of the patients. Conclusion: The results of this study suggest that bronchial wall thickening, ILD and emphysema are common chronic pulmonary sequelae of sulfur mustard injury. HRCT of the chest should be considered as the imaging modality of choice in chemical war injury

  10. Low chronic radiation doses

    International Nuclear Information System (INIS)

    In the context of the Chernobyl and Fukushima accidents where large territories have been contaminated durably and as consequence where local populations are submitted to chronic low radiation doses, IRSN (French institute for radiation protection and nuclear safety) has led various studies to assess the impact of chronic low doses. Studies about the effects of uranium on marine life show that the impact is strongly dependent on the initial state of the individual (zebra Danio rerio fish). The studies about the impact of chronic low doses due to cesium and strontium contamination show different bio-accumulations: 137Cs is found in the animal's whole body with higher concentrations in muscles and kidneys while 90Sr is found almost exclusively in bones and it accumulates more in female mice than in males. The study dedicated to the sanitary impact of chronic low doses on the workers of the nuclear industry shows a higher risk for developing a leukemia, a pleural cancer or a melanoma but no correlation appears between doses and the appearance of the pleural cancer or the melanoma. (A.C.)

  11. Chronic kidney disease

    Science.gov (United States)

    ... enable JavaScript. Chronic kidney disease is the slow loss of kidney function over time. The main job of the kidneys is to remove wastes and excess water from the body. Causes ... over months or years. You may not notice any symptoms for some time. The loss of function may be so slow that you ...

  12. Refractory chronic migraine

    DEFF Research Database (Denmark)

    Martelletti, Paolo; Katsarava, Zaza; Lampl, Christian;

    2014-01-01

    The debate on the clinical definition of refractory Chronic Migraine (rCM) is still far to be concluded. The importance to create a clinical framing of these rCM patients resides in the complete disability they show, in the high risk of serious adverse events from acute and preventative drugs and...

  13. Chronic fatigue syndrome.

    NARCIS (Netherlands)

    Prins, J.B.; Meer, J.W.M. van der; Bleijenberg, G.

    2006-01-01

    During the past two decades, there has been heated debate about chronic fatigue syndrome (CFS) among researchers, practitioners, and patients. Few illnesses have been discussed so extensively. The existence of the disorder has been questioned, its underlying pathophysiology debated, and an effective

  14. [Chronic lichenoid keratosis].

    Science.gov (United States)

    Skorupka, M; Kuhn, A; Mahrle, G

    1992-02-01

    We report on a 41-year-old woman with keratosis lichenoides chronica, a disorder first described by Kaposi in 1886 as "lichen moniliformis", who later also developed chronic lymphatic leukaemia. Since Kaposi's original report, 38 additional cases have been reported. Occurrence of keratosis lichenoides chronica associated with malignant disorders has not previously been described. PMID:1548136

  15. Chronic Mononucleosis Syndrome

    OpenAIRE

    Shortt, S. E. D.; Haynes, E. R.

    1986-01-01

    Debilitating illness in patients with only vague symptoms and minimal findings from physical examination and routine laboratory tests is frustrating for both patient and physician. A case of chronic mononucleosis is presented, and the literature describing the clinical and laboratory features of the syndrome is reviewed, with reference to four recent studies. Guidelines for diagnosis are suggested.

  16. What Is Chronic Pain?

    Medline Plus

    Full Text Available ... with chronic pain is that when we start looking for an explanation it’s not so much that we’re looking in the wrong place, but we may be looking in the wrong time. And what I mean ...

  17. Chronic Myeloproliferative Neoplasms Treatment

    Science.gov (United States)

    ... Cancers by Body Location Childhood Cancers Adolescent & Young Adult Cancers Metastatic Cancer Recurrent Cancer Research NCI’s Role in ... on the hands and feet. Muscle pain. Itching. Diarrhea . Stages of Chronic Myeloproliferative Neoplasms Key Points There is no standard staging system ...

  18. Autoantibodies in chronic pancreatitis

    DEFF Research Database (Denmark)

    Rumessen, J J; Marner, B; Pedersen, N T;

    1985-01-01

    In 60 consecutive patients clinically suspected of having chronic pancreatitis the serum concentration of the immunoglobulins (IgA, IgG, IgM), the IgG- and IgA-type non-organ-specific autoantibodies against nuclear material (ANA), smooth and striated muscle, mitochondria, basal membrane, and...

  19. What Is Chronic Pain?

    Medline Plus

    Full Text Available ... manageable, but chronic pain is different. And because it is different, we need to think about it in very different ways. Ed Covington, M.D.: ... no apparent physical injury or illness to explain it. The physician and the patient are accustomed to ...

  20. Chronic Pain: Symptoms, Diagnosis, & Treatment

    Science.gov (United States)

    ... in the treatment. Treatment With chronic pain, the goal of treatment is to reduce pain and improve ... some treatments used for chronic pain. Less invasive psychotherapy, relaxation therapies, biofeedback, and behavior modification may also ...