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Sample records for brachytherapy preliminary results

  1. MRI/TRUS data fusion for prostate brachytherapy. Preliminary results

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    Reynier, Christophe; Fourneret, Philippe; Dusserre, André; Gay-Jeune, Cécile; Descotes, Jean-Luc; Bolla, Michel; Giraud, Jean-Yves

    2008-01-01

    Prostate brachytherapy involves implanting radioactive seeds (I125 for instance) permanently in the gland for the treatment of localized prostate cancers, e.g., cT1c-T2a N0 M0 with good prognostic factors. Treatment planning and seed implanting are most often based on the intensive use of transrectal ultrasound (TRUS) imaging. This is not easy because prostate visualization is difficult in this imaging modality particularly as regards the apex of the gland and from an intra- and interobserver variability standpoint. Radioactive seeds are implanted inside open interventional MR machines in some centers. Since MRI was shown to be sensitive and specific for prostate imaging whilst open MR is prohibitive for most centers and makes surgical procedures very complex, this work suggests bringing the MR virtually in the operating room with MRI/TRUS data fusion. This involves providing the physician with bi-modality images (TRUS plus MRI) intended to improve treatment planning from the data registration stage. The pape...

  2. Brachytherapy with Iodine-125 seeds in initial prostate cancer treatment: preliminary results and complications

    International Nuclear Information System (INIS)

    Low-dose rate brachytherapy as monotherapy is a treatment option for early stage prostate cancer. It consists of the permanent implantation of Iodine-125 seeds in the gland of patients with PSA≤ 10ng/ml, Gleason ≤ 6 and clinical stage from T1 until T2b. The 68 patients enrolled in this study were treated by the technique developed at the Northwest Pacific Hospital, Seattle, USA. Sixty four patients treated with low-dose rate brachytherapy were followed for 4-48 months (median = 32 months). The treatment results were based on the periodic evaluation of the total PSA values and it was found that, after this time, 55% of patients had total PSA equal or below 1ng/ml. Post-implant morbidities were evaluated, showing that 89% presented negligible or low grade side effects. Low-dose rate brachytherapy is an appealing option for the treatment of early stage prostate cancer because of its successful local control and low morbidity. (author)

  3. Ruthenium-106 brachytherapy for uveal melanomas. Preliminary results: a single institutional experience; Braquiterapia com rutenio-106 em melanomas uveais. Resultados preliminares: experiencia uni-instuticional

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    Dias, Rodrigo Souza; Giordani, Adelmo Jose; Segreto, Helena Regina Comodo; Segreto, Roberto Araujo [Universidade Federal de Sao Paulo/Escola Paulista de Medicina (Unifesp/EPM), Sao Paulo, SP (Brazil). Departamento de Medicina. Setor de Radioterapia ; Erwenne, Clelia Maria; Teixeira, Luiz Fernando [Universidade Federal de Sao Paulo/Escola Paulista de Medicina (UNIFESP/EPM), Sao Paulo, SP (Brazil). Dept. de Oftalmologia]. E-mail: segreto. dmed@epm.br

    2007-03-15

    Objective: To analyze the early response of uveal melanomas in patients treated with ruthenium-106 brachytherapy. Materials And Methods: In the period between April 2002 and July 2003, 20 patients diagnosed with uveal melanoma were submitted to ruthenium-106 brachytherapy. The calculated dose delivered at the apex of the tumor ranged between 55 Gy and 100 Gy. Patients with lesions greater than 5 mm were submitted to transpupillary thermotherapy concomitantly with ophthalmic plaque insertion. Results: As regards the lesions site, 75% of the lesions were located in the choroid, 15% in the iris, and the remainder 10% in the ciliary body. In a median 19-month-follow-up, the progression-free survival for brachytherapy was 69%, and 87% for associated brachytherapy and transpupillary thermotherapy. A significant tumor height reduction was observed after treatment. No patient was submitted to enucleation. Conclusion: Our preliminary results show that ruthenium-106 brachytherapy is an appropriate method for conservative treatment of patients with uveal melanomas in terms of local management, ocular and visual acuity preservation with an acceptable complications incidence rate. (author)

  4. Stereotactic body radiation therapy via helical tomotherapy to replace brachytherapy for brachytherapy-unsuitable cervical cancer patients – a preliminary result

    Directory of Open Access Journals (Sweden)

    Hsieh CH

    2013-02-01

    Full Text Available Chen-Hsi Hsieh,1–3 Hui-Ju Tien,1 Sheng-Mou Hsiao,4 Ming-Chow Wei,4 Wen-Yih Wu,4 Hsu-Dong Sun,4 Li-Ying Wang,5 Yen-Ping Hsieh,6 Yu-Jen Chen,3,7–9 Pei-Wei Shueng1,101Department of Radiation Oncology, Far Eastern Memorial Hospital, Taipei, Taiwan; 2Department of Medicine, 3Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; 4Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Taipei, Taiwan; 5School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan; 6Department of Senior Citizen Service Management, National Taichung University of Science and Technology, Taichung, Taiwan; 7Department of Radiation Oncology, 8Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan; 9Graduate Institute of Sport Coaching Science, Chinese Culture University, Taipei, Taiwan; 10Department of Radiation Oncology, National Defense Medical Center, Taipei, TaiwanAim: To review the experience and to evaluate the results of stereotactic body radiation therapy (SBRT via helical tomotherapy (HT, for the treatment of brachytherapy-unsuitable cervical cancer.Methods: Between September 1, 2008 to January 31, 2012, nine cervical cancer patients unsuitable for brachytherapy were enrolled. All of the patients received definitive whole pelvic radiotherapy with or without chemotherapy, followed by SBRT via HT.Results: The actuarial locoregional control rate at 3 years was 78%. The mean biological equivalent dose in 2-Gy fractions of the tumor, rectum, bladder, and intestines was 76.0 ± 7.3, 73.8 ± 13.2, 70.5 ± 10.0, and 43.1 ± 7.1, respectively. Only two had residual tumors after treatment, and the others were tumor-free. Two patients experienced grade 3 acute toxicity: one had diarrhea; and another experienced thrombocytopenia. There were no grade 3 or 4 subacute toxicities. Three patients suffered from manageable rectal bleeding in

  5. The seven-year preliminary results of brachytherapy with Iodine-125 seeds for localized prostate cancer treated at a Brazilian single-center

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    Carlos A. S. Franca

    2007-12-01

    Full Text Available OBJECTIVE: To report the seven-year preliminary results of a single-center on brachytherapy with Iodine-125 seeds, used in combination with external beam radiotherapy in selected patients with localized prostate cancer (T1-T2. MATERIALS AND METHODS: All 105 patients treated by brachytherapy with Iodine-125 seeds, from January/1998 to December/2004, were retrospectively analyzed. The prescribed dose was 144 Gy at the periphery of the prostate for isolated brachytherapy, and 110 Gy for the combination with external beam radiotherapy. The external beam radiotherapy dose was 45 Gy, at the prostatic bed. Neoadjuvant hormone therapy was indicated for selected patients, who received luteinizing hormone-releasing hormone (LH-RH and/or antiandrogens. For definition of biochemical relapse, it was adopted the American Society for Therapeutic Radiology and Oncology consensus. RESULTS: Of the 105 patients treated, 90 were followed for a mean period of 70 months. Biochemical disease control was achieved in 62 (69% and biochemical recurrence was manifested in 28 (31%. The analysis of each risk group showed biochemical disease control rates of 79%, 71% and 52% in the low, intermediate and high risk groups, respectively. The mean time for biochemical recurrence was 22 months. Genitourinary acute toxicity was classified as grade 0-2 (RTOG in 88.5% and in 94.2% for the late toxicity (RTOG/EORTC. Gastrointestinal acute toxicity was graded as 0-2 (RTOG in 100% and in 97.7% for the late morbidity. No grade 5 was detected. CONCLUSIONS: Brachytherapy with Iodine-125 seeds is an effective alternative treatment for early stage prostatic cancer, with good biochemical disease control rates and low to moderate toxicity. The best results were obtained in low and intermediate risk patients.

  6. Preliminary results of a phase I/II study of HDR brachytherapy alone for T1/T2 breast cancer

    International Nuclear Information System (INIS)

    Purpose: To investigate the feasibility, toxicity, cosmetic outcome, and local control of high-dose-rate (HDR) brachytherapy alone without whole breast external beam irradiation for early-stage breast carcinoma. Methods and Materials: Between June 1997 and August 1999, 32 women diagnosed with a total of 33 AJCC Stage I/II breast carcinomas underwent surgical breast excision and postoperative irradiation using HDR brachytherapy interstitial implantation as part of a multi-institutional clinical Phase I/II protocol. Eligible patients included those with T1, T2, N0, N1 (≤3 nodes positive), and M0 tumors of nonlobular histologic features with negative surgical margins, no extracapsular lymph node extension, and a negative postexcision mammogram. Brachytherapy catheters were placed at the initial excision, reexcision, or either sentinel or full-axillary sampling. Direct visualization, surgical clips, and ultrasound and/or CT scan assisted in the delineation of the target volume, defined as the excision cavity plus a 2-cm margin. High-activity 192Ir (3-10 Ci) was used to deliver 340 cGy/fraction, 2 fractions/d, for 5 consecutive days, to a total dose of 34 Gy to the target volume. Source position and dwell times were calculated using standard volume optimization techniques. Results: The median follow-up of all patients was 33 months, and the mean patient age was 63 years. The mean tumor size was 1.3 cm, and 55% had an extensive intraductal component. Three patients had positive axillary nodes. Two patients experienced moderate perioperative pain that required narcotic analgesics. No peri- or postoperative infections occurred. No wound healing problems and no significant skin reactions related to the implant developed. The Radiation Therapy Oncology Group late radiation morbidity scoring scheme was applied to the entire 33-case cohort. In the assessment of the skin, 30 cases were Grade 0-1 and 3 cases were Grade 2. Subcutaneous toxicity was scored as 11 patients with

  7. Preliminary results of concurrent chemotherapy and radiation therapy using high-dose-rate brachytherapy for cervical cancer

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    Lee, Kyung Ja; Lee, Ji Hye; Lee, Re Na; Suh, Hyun Suk [Ewha Womans University College of Medicine, Seoul (Korea, Republic of)

    2006-09-15

    rate was 13% and distant metastatic rate was 3.3%. The crude rate of minor hematologic complications (RTOG grade 1-2) occurred in 3 patients (10%) and one patient had suffered from severe leukopenia (RTOG grade 4) during concurrent treatment. Acute minor enterocolitis (RTOG grade 1-2) occurred in 11 patients (37%) and one patient (3%) was suffered from colon perforation during radiation therapy. Late colitis of RTOG grade 1 occurred in 5 patients (15%). Acute cystitis of RTOG grade 1 occurred in 12 patients (40%) and late cystitis of RTOG grade 2 occurred in one patient (3%). No treatment related death was seen. The results of this study suggest that the concurrent chemoradiation therapy with HDR brachytherapy could be accepted as an effective and safe treatment for cervical cancer.

  8. Preliminary results of magnetic resonance imaging-aided high-dose-rate interstitial brachytherapy for recurrent uterine carcinoma after curative surgery

    International Nuclear Information System (INIS)

    This report presents initial experience with imaging-aided high-dose-rate interstitial brachytherapy (HDR-ISBT) for post-operative recurrence of uterine carcinoma. Fourteen patients presenting with post-operative recurrence of uterine carcinoma (nine cervix and five corpus) between July 2005 and October 2008 were enrolled in this study (median follow-up: 37 months, range: 6-59 months). We implanted magnetic resonance imaging (MRI)-compatible plastic applicators using our own ambulatory technique. HDR-ISBT treatment consisted of twice-a-day irradiation of 6 Gy each with at least a six-hour interval to provide the total prescribed dose. Treatment was based on treatment planning-computed tomography with MRI as a reference. Seven patients were treated with a combination of ISBT (median 30 Gy/5 fractions; range: 27-33 Gy) and external beam radiation therapy (EBRT), and the other seven with brachytherapy only (median 54 Gy/9 fractions; range: 48-54 Gy), one of whom had previously received pelvic EBRT. The three-year estimates of local control and overall survival rates were 77.9% (95% confidence interval (CI): 55.8-100%) and 77.1% (95% CI: 54.2-100%), respectively. Two patients, who had received combined treatment with EBRT showed untoward reactions, including a grade 3 subileus and grade 2 constipation. Another patient, who had been treated with ISBT alone, developed grade 2 urinary constriction. Our imaging-aided HDR-ISBT for post-operative recurrence of uterine carcinoma was found to be practical with promising preliminary results. (author)

  9. Brachytherapy

    Science.gov (United States)

    ... News Physician Resources Professions Site Index A-Z Brachytherapy What is Brachytherapy and how is it used? ... will I feel during this procedure? What is brachytherapy and how is it used? Brachytherapy is a ...

  10. Penile brachytherapy: Results for 49 patients

    International Nuclear Information System (INIS)

    Purpose: To report results for 49 men with squamous cell carcinoma (SCC) of the penis treated with primary penile interstitial brachytherapy at one of two institutions: the Ottawa Regional Cancer Center, Ottawa, and the Princess Margaret Hospital, Toronto, Ontario, Canada. Methods and Materials: From September 1989 to September 2003, 49 men (mean age, 58 years; range, 22-93 years) had brachytherapy for penile SCC. Fifty-one percent of tumors were T1, 33% T2, and 8% T3; 4% were in situ and 4% Tx. Grade was well differentiated in 31%, moderate in 45%, and poor in 2%; grade was unspecified for 20%. One tumor was verrucous. All tumors in Toronto had pulsed dose rate (PDR) brachytherapy (n = 23), whereas those in Ottawa had either Iridium wire (n 22) or seeds (n = 4). Four patients had a single plane implant with a plastic tube technique, and all others had a volume implant with predrilled acrylic templates and two or three parallel planes of needles (median, six needles). Mean needle spacing was 13.5 mm (range, 10-18 mm), mean dose rate was 65 cGy/h (range, 33-160 cGy/h), and mean duration was 98.8 h (range, 36-188 h). Dose rates for PDR brachytherapy were 50-61.2 cGy/h, with no correction in total dose, which was 60 Gy in all cases. Results: Median follow-up was 33.4 months (range, 4-140 months). At 5 years, actuarial overall survival was 78.3% and cause-specific survival 90.0%. Four men died of penile cancer, and 6 died of other causes with no evidence of recurrence. The cumulative incidence rate for never having experienced any type of failure at 5 years was 64.4% and for local failure was 85.3%. All 5 patients with local failure were successfully salvaged by surgery; 2 other men required penectomy for necrosis. The soft tissue necrosis rate was 16% and the urethral stenosis rate 12%. Of 8 men with regional failure, 5 were salvaged by lymph node dissection with or without external radiation. All 4 men with distant failure died of disease. Of 49 men, 42 had an intact

  11. The Preliminary Prototype of Medium Dose Rate Brachytherapy Equipment

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    A. Satmoko

    2013-08-01

    Full Text Available A preliminary prototype of a brachytherapy equipment has been constructed. The work started by developing conceptual design, followed by basic design and detailed design. In the conceptual design, design requirements are stated. In the basic design, technical specifications for main components are determined. In detailed design, general drawings are discussed. The prototype consists of three main systems: a mechanical system, an instrumentation system, and a safety system. The mechanical system assures the movement mechanism of the isotope source position beginning from the standby position until the applicators. It consists of three main modules: a position handling module, a container module, and a channel distribution module. The position handling module serves to move the isotope source position. As shielding, the second module is to store the source when the equipment is in standby position. The prototype provides 12 output channels. The channel selection is performed by the third module. The instrumentation system controls the movement of source position by handling motor operations. It consists of several modules. A microcontroller module serves as a control center whose task includes both controlling motors and communicating with computer. A motor module serves to handle motors. 10 sensors, including their signal conditionings, are introduced to read the environment conditions of the equipment. LEDs are used to display these conditions. In order to facilitate the operators’ duty, communication via RS232 is provided. The brachytherapy equipment can therefore be operated by using computer. Interface software is developed using C# language. To complete both mechanical and instrumentation systems performance, a safety system is developed to make sure that the safety for operator and patients from receiving excessive radiation. An interlock system is introduced to guard against abnormal conditions. In the worst case, a manual intervention

  12. Accelerated partial breast irradiation with iridium-192 multicatheter PDR/HDR brachytherapy. Preliminary results of the German-Austrian multicenter trial

    International Nuclear Information System (INIS)

    Purpose: to evaluate perioperative morbidity, toxicity, and cosmetic outcome in patients treated with interstitial brachytherapy to the tumor bed as the sole irradiation modality after breast-conserving surgery. Patients and methods: from November 1, 2000 to January 31, 2004, 176 women with early-stage breast cancer became partakers in a protocol of tumor bed irradiation alone using pulsed-dose-rate (PDR) or high-dose-rate (HDR) interstitial multicatheter implants. Patients became eligible, if their tumor was an infiltrating carcinoma ≤ 3 cm in diameter, the surgical margins were clear by at least 2 mm, the axilla was surgically staged node-negative, the tumor was estrogen and/or progesterone receptor-positive, well or moderately differentiated (G1/2), the tumor did not contain an extensive intraductal component (EIC) and the patient's age was > 35 years. Implants were positioned using a template guide, delivering either 49.8 Gy in 83 consecutive hours (PDR) or 32.0 Gy in two daily fractions over 4 days (HDR). Perioperative morbidity, toxicity, and cosmetic outcome were assessed. Interim findings of the first 69 patients, who were treated in this multicenter trial, after a median follow-up of 24 months (range, 15-39 months) are presented. Results: one of the 69 patients (1.4%) developed a bacterial infection of the implant. No other perioperative complications, for example bleeding or hematoma, were observed. Acute toxicity was low: 2.9% of the patients (2/69) experienced mild radiodermatitis. Late toxicity: hypersensation/mild pain 7.2% (5/69), intermittent but tolerable pain 1.4% (1/69), mild dyspigmentation 10.1% (7/69), mild fibrosis 11.6% (8/69), moderate fibrosis 1.4% (1/69), mild telangiectasia (2) 11.6% (8/69), and moderate teleangiectasia (1-4 cm2) 1.4% (1/69). Good to excellent cosmetic results were observed in 92.4% of the patients evaluated. All patients (n = 176) remained disease-free to the date of evaluation. Conclusion: this analysis indicates

  13. Accelerated partial breast irradiation with iridium-192 multicatheter PDR/HDR brachytherapy. Preliminary results of the German-Austrian multicenter trial

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    Ott, O.J.; Lotter, M.; Sauer, R.; Strnad, V. [Dept. of Radiation Oncology, Univ. Hospital Erlangen, Erlangen (Germany); Poetter, R.; Resch, A. [Dept. of Radiotherapy and Radiobiology, Univ. Hospital AKH Wien, Vienna (Austria); Hammer, J. [Dept. of Radiation Oncology, Barmherzige Schwestern Hospital Linz, Linz (Austria); Hildebrandt, G. [Dept. of Radiation Oncology, Univ. Hospital Leipzig, Leipzig (Germany); Poehls, U.; Beckmann, M.W. [Dept. of Gynecology, Univ. Hospital Erlangen, Erlangen (Germany)

    2004-10-01

    Purpose: to evaluate perioperative morbidity, toxicity, and cosmetic outcome in patients treated with interstitial brachytherapy to the tumor bed as the sole irradiation modality after breast-conserving surgery. Patients and methods: from November 1, 2000 to January 31, 2004, 176 women with early-stage breast cancer became partakers in a protocol of tumor bed irradiation alone using pulsed-dose-rate (PDR) or high-dose-rate (HDR) interstitial multicatheter implants. Patients became eligible, if their tumor was an infiltrating carcinoma {<=} 3 cm in diameter, the surgical margins were clear by at least 2 mm, the axilla was surgically staged node-negative, the tumor was estrogen and/or progesterone receptor-positive, well or moderately differentiated (G1/2), the tumor did not contain an extensive intraductal component (EIC) and the patient's age was > 35 years. Implants were positioned using a template guide, delivering either 49.8 Gy in 83 consecutive hours (PDR) or 32.0 Gy in two daily fractions over 4 days (HDR). Perioperative morbidity, toxicity, and cosmetic outcome were assessed. Interim findings of the first 69 patients, who were treated in this multicenter trial, after a median follow-up of 24 months (range, 15-39 months) are presented. Results: one of the 69 patients (1.4%) developed a bacterial infection of the implant. No other perioperative complications, for example bleeding or hematoma, were observed. Acute toxicity was low: 2.9% of the patients (2/69) experienced mild radiodermatitis. Late toxicity: hypersensation/mild pain 7.2% (5/69), intermittent but tolerable pain 1.4% (1/69), mild dyspigmentation 10.1% (7/69), mild fibrosis 11.6% (8/69), moderate fibrosis 1.4% (1/69), mild telangiectasia (< 1 cm{sup 2}) 11.6% (8/69), and moderate teleangiectasia (1-4 cm{sup 2}) 1.4% (1/69). Good to excellent cosmetic results were observed in 92.4% of the patients evaluated. All patients (n = 176) remained disease-free to the date of evaluation. Conclusion

  14. Low-dose-rate brachytherapy as the sole radiation modality in the management of patients with early-stage breast cancer treated with breast-conserving therapy: preliminary results of a pilot trial

    International Nuclear Information System (INIS)

    Purpose: We present the preliminary findings of our in-house protocol treating the tumor bed alone after lumpectomy with low-dose-rate (LDR) interstitial brachytherapy in selected patients with early-stage breast cancer treated with breast-conserving therapy (BCT). Methods and Materials: Since March 1, 1993, 60 women with early-stage breast cancer were entered into a protocol of tumor bed irradiation only using an interstitial LDR implant with iodine-125. Patients were eligible if the tumor was ≤3 cm, margins were ≥2 mm, there was no extensive intraductal component, the axilla was surgically staged, and a postoperative mammogram was performed. Implants were placed using a standardized template either at the time of reexcision or shortly after lumpectomy. A total of 50 Gy was delivered at 0.52 Gy/h over a period of 96 h to the lumpectomy bed plus a 2-cm margin. Perioperative complications, cosmetic outcome, and local control were assessed. Results: The median follow-up for all patients is 20 months. Three patients experienced minimal perioperative pain that required temporary nonnarcotic analgesics. There have been four postoperative infections which resolved with oral antibiotics. No significant skin reactions related to the implant were noted and no patient experienced impaired would healing. Early cosmetic results reveal minimal changes consisting of transient hyperpigmentation of the skin at the puncture sites and temporary induration in the tumor bed. Good to excellent cosmetic results were noted in all 19 patients followed up a minimum of 24 months posttherapy. To date, 51 women have obtained 6-12-month follow-up mammograms and no recurrences have been noted. All patients currently have no physical signs of recurrence, and no patient has failed regionally or distantly. Conclusion: Treatment of the tumor bed alone with LDR interstitial brachytherapy appears to be well tolerated, and early results are promising. Long-term follow-up of these patients is

  15. Paraspinal tumors: Techniques and results of brachytherapy

    International Nuclear Information System (INIS)

    Because of their proximity to nerve roots and the spinal cord, it is frequently difficult to achieve complete resection of paraspinal tumors. We have used brachytherapy in an attempt to prevent local recurrence and its associated neurological sequelae. This report analyzes our experience with 35 patients to determine the feasibility, optimal techniques, and efficacy of this approach. The tumor types were non small-cell lung cancer (18), sarcomas (9), and other tumor types (8). Temporary, single plane implants using Ir-192 (median minimum peripheral dose 3000 cGy) were used in 21 patients, and permanent I-125 implants were used in 14 cases (median matched peripheral dose 12,500 cGy). Local control was achieved in 51% (18/35). However, local control was poor when lung cancers were implanted and in cases where the dura was exposed. Radiation myelitis did not occur despite the combined effects of previous external beam radiotherapy (N = 21) and brachytherapy. Our experience demonstrates that combined surgery and paraspinal brachytherapy can be performed with acceptable toxicity and is reasonably effective in preventing local relapse and its neurologic sequelae, particularly for tumors other than lung cancers

  16. [Brachytherapy].

    Science.gov (United States)

    Itami, Jun

    2014-12-01

    Brachytherapy do require a minimal expansion of CTV to obtain PTV and it is called as ultimate high precision radiation therapy. In high-dose rate brachytherapy, applicators will be placed around or into the tumor and CT or MRI will be performed with the applicators in situ. With such image-guided brachytherapy (IGBT) 3-dimensional treatment planning becomes possible and DVH of the tumor and organs at risk can be obtained. It is now even possible to make forward planning satisfying dose constraints. Traditional subjective evaluation of brachytherapy can be improved to the objective one by IGBT. Brachytherapy of the prostate cancer, cervical cancer, and breast cancer with IGBT technique was described. PMID:25596048

  17. Brachytherapy with Iodine-125 seeds in initial prostate cancer treatment: preliminary results and complications; Braquiterapia com sementes de Iodo-125 no tratamento do cancer inicial de prostata: resultados e complicacoes preliminares

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    Penna, Antonio Belmiro R. Campbell [Universidade Federal, Rio de Janeiro, RJ (Brazil). Faculdade de Medicina. Programa de Pos-graduacao em Radiologia]. E-mail: info@radiobot.com.br; Bernabe, Antonio Jose S. [Sociedade Brasileira de Urologia, Rio de Janeiro, RJ (Brazil); Marchiori, Edson [Universidade Federal Fluminense, Niteroi, RJ (Brazil). Dept. de Radiologia

    2005-07-01

    Low-dose rate brachytherapy as monotherapy is a treatment option for early stage prostate cancer. It consists of the permanent implantation of Iodine-125 seeds in the gland of patients with PSA{<=} 10ng/ml, Gleason {<=} 6 and clinical stage from T1 until T2b. The 68 patients enrolled in this study were treated by the technique developed at the Northwest Pacific Hospital, Seattle, USA. Sixty four patients treated with low-dose rate brachytherapy were followed for 4-48 months (median = 32 months). The treatment results were based on the periodic evaluation of the total PSA values and it was found that, after this time, 55% of patients had total PSA equal or below 1ng/ml. Post-implant morbidities were evaluated, showing that 89% presented negligible or low grade side effects. Low-dose rate brachytherapy is an appealing option for the treatment of early stage prostate cancer because of its successful local control and low morbidity. (author)

  18. Brachytherapy in Lip Carcinoma: Long-Term Results

    International Nuclear Information System (INIS)

    Purpose: The aim of this study was to evaluate the effectiveness of low-dose-rate brachytherapy for local control and relapse-free survival in squamous cell and basal cell carcinomas of the lips. We compared two groups: one with tumors on the skin and the other with tumors on the lip. Patients and methods: All patients had been treated at Claudius Regaud Cancer Centre from 1990 to 2008 for squamous cell or basal cell carcinoma. Low-dose-rate brachytherapy was performed with iridium 192 wires according to the Paris system rules. On average, the dose delivered was 65 Gy. Results: 172 consecutive patients were included in our study; 69 had skin carcinoma (squamous cell or basal cell), and 92 had squamous cell mucosal carcinoma. The average follow-up time was 5.4 years. In the skin cancer group, there were five local recurrences and one lymph node recurrence. In the mucosal cancer group, there were ten local recurrences and five lymph node recurrences. The 8-year relapse-free survival for the entire population was 80%. The 8-year relapse-free survival was 85% for skin carcinoma 75% for mucosal carcinoma, with no significant difference between groups. The functional results were satisfactory for 99% of patients, and the cosmetic results were satisfactory for 92%. Maximal toxicity observed was Grade 2. Conclusions: Low-dose-rate brachytherapy can be used to treat lip carcinomas at Stages T1 and T2 as the only treatment with excellent results for local control and relapse-free survival. The benefits of brachytherapy are also cosmetic and functional, with 91% of patients having no side effects.

  19. Brachytherapy in Lip Carcinoma: Long-Term Results

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    Guibert, Mireille, E-mail: mireilleguib@voila.fr [Department of Head and Neck Surgery, Larrey Hospital, Toulouse (France); David, Isabelle [Department of Radiation Oncology, Claudius Regaud Institut, Toulouse (France); Vergez, Sebastien [Department of Head and Neck Surgery, Larrey Hospital, Toulouse (France); Rives, Michel [Department of Radiation Oncology, Claudius Regaud Institut, Toulouse (France); Filleron, Thomas [Department of Epidemiology, Claudius Regaud Institut, Toulouse (France); Bonnet, Jacques; Delannes, Martine [Department of Radiation Oncology, Claudius Regaud Institut, Toulouse (France)

    2011-12-01

    Purpose: The aim of this study was to evaluate the effectiveness of low-dose-rate brachytherapy for local control and relapse-free survival in squamous cell and basal cell carcinomas of the lips. We compared two groups: one with tumors on the skin and the other with tumors on the lip. Patients and methods: All patients had been treated at Claudius Regaud Cancer Centre from 1990 to 2008 for squamous cell or basal cell carcinoma. Low-dose-rate brachytherapy was performed with iridium 192 wires according to the Paris system rules. On average, the dose delivered was 65 Gy. Results: 172 consecutive patients were included in our study; 69 had skin carcinoma (squamous cell or basal cell), and 92 had squamous cell mucosal carcinoma. The average follow-up time was 5.4 years. In the skin cancer group, there were five local recurrences and one lymph node recurrence. In the mucosal cancer group, there were ten local recurrences and five lymph node recurrences. The 8-year relapse-free survival for the entire population was 80%. The 8-year relapse-free survival was 85% for skin carcinoma 75% for mucosal carcinoma, with no significant difference between groups. The functional results were satisfactory for 99% of patients, and the cosmetic results were satisfactory for 92%. Maximal toxicity observed was Grade 2. Conclusions: Low-dose-rate brachytherapy can be used to treat lip carcinomas at Stages T1 and T2 as the only treatment with excellent results for local control and relapse-free survival. The benefits of brachytherapy are also cosmetic and functional, with 91% of patients having no side effects.

  20. Treatment of Peyronies disease with brachytherapy - assessment of the results

    International Nuclear Information System (INIS)

    The treatment methods of Induratio penis plastica applied so far yield conflicting results. The Radiology Clinic at the Higher Institute Medicine - Plovdiv has reach experience with the treatment of this disease by brachytherapy alone, or combined with medicines (vitamin E and Hyalase). The purpose of the paper is to evaluate the results after a 3-year follow-up study. From 1994 to 1997, 118 men aged 40 to 72 were treated with one to three courses of local application of a special 137Cs moulage. Staging of the disease was done on the basis of criteria proposed by Alth in 1984 - location, plaque number and size, deformity of erection and pain. Brachytherapy was carried using the moulage technique with 1'37Cs applicators taking into account the homogeneity rules. The first course consisted of 5 applications of 3.75 Gy to realization a dose of 18.75 Gy. Normally the treatment ended after the first course, in cases of unsatisfactory effect it was repeated in 3 months, and rarely a third course was needed. 90 patients were treated with one course, 20 with two, and 8 with three. Complete regression was achieved in 11.9%; partial regression more than 50% in 68.6%; partial regression less than 50% in 12.7%; no improvement - 6.8% of the patients. A significant correlation was noted between the plaque size and number and the therapeutic effect. Upon plaque regression the pain decreased first, while reverse development of erection deformity was much slower. The encouraging results prove that brachytherapy is a promising and non-invasive method of treatment (author)

  1. Intraluminal brachytherapy in treatment of malignant obstructive jaundice

    International Nuclear Information System (INIS)

    Objective: To study the practicability and preliminary effect of intraluminal brachytherapy in treatment of malignant obstructive jaundice. Methods: Intraluminal brachytherapy was performed in 4 patients who had been treated with biliary stent implantation. Results: No complications related to intraluminal brachytherapy had happened. One patient was followed up by means of CT, showing reduction in tumor size. Conclusion: Intraluminal brachytherapy is a safe and effective method in treating malignant tumor causing obstructive jaundice

  2. Patterns of care for brachytherapy in Europe (PC BE) in Spain and Poland: Comparative results

    International Nuclear Information System (INIS)

    Background: Cancer incidence and its mortality depend on a number of factors, including age, socio-economic status and geographic situation, and its incidence is growing around the world. Cancer incidence in Europe is now about 4000 patients per million per year and due to the ageing population a yearly increase of 1 - 1.5 % in cancer cases is estimated in the next two decades. Most of the cancer treatments will include external beam radiotherapy or brachytherapy. Brachytherapy has increased its use as a radical or palliative treatment and become more sophisticated with the spread of pulsed dose rate and high dose rate afterloading machines, and the use of new planning systems has additionally improved quality of treatment. Aim: The aim of the present study was to compare two countries (Poland and Spain) and to report the differences in the use of brachytherapy in these countries. For this reason, several characteristics related to brachytherapy were compared. Materials/Methods: The data used were collected using a web site questionnaire for the year 2002 where every centre that participated in the survey could introduce, change or update the information requested. Hospitals included in the study were those that provided data on brachytherapy, because our objective was to compare the brachytherapy facilities between Poland and Spain. Results: Data were available for 22 centres in Poland and 39 centres in Spain that provided brachytherapy in 2002. Spain having more centres that applied brachytherapy (1.0 centre per 1,000,000 inhabitants in Spain vs. 0.6 centre per 1,000,000 inhabitants in Poland), the average number of brachytherapy patients per centre is lower in Spain than in Poland, 137 and 382 respectively. The 5 main tumour sites treated with brachytherapy in Poland were: gynaecological (73.7 %), bronchus (13.0 %), breast (2.8 %), prostate (2.4 %) and head and neck (1.6 %). In Spain they were: gynaecological (59.7 %), breast (15.4 %), prostate (12.8 %), head

  3. LOW-DOSE RATE BRACHYTHERAPY FOR PROSTATE CANCER: DIFFERENT INDICATIONS – DIFFERENT RESULTS

    Directory of Open Access Journals (Sweden)

    V. A. Biryukov

    2014-07-01

    Full Text Available In Russia, there is presently a growing interest in low-dose intratissue radiotherapy (brachytherapy for locally advanced prostate cancer (PC. Since its inception, current brachytherapy has undergone a number of significant changes in terms of improved visualization and better treatment planning and monitoring, which is sure to have affected the higher quality of their performance and better long-term results. The main purpose of the given paper is to generalize the data of foreign investigators who have the greatest experience with brachytherapy for its further use in the treatment of patients with locally advanced PC under the conditions of Russian clinics.

  4. Results of stereotactic brachytherapy used in the initial management of patients with glioblastoma

    International Nuclear Information System (INIS)

    Recent studies have shown a survival benefit for patients with recurrent glioblastomas treated with stereotactic brachytherapy. On the basis of these encouraging results, we began a prospective study in 1987 to evaluate the use of brachytherapy in patients with newly diagnosed glioblastoma. Patients were considered eligible for this study if they met the following criteria: Karnofsky performance status 70% or greater; tumor size not greater than 5 cm in any dimension; a radiographically well delineated, supratentorial lesion not involving the ependymal surfaces; and pathologically confirmed glioblastoma. We treated 35 such patients between 1987 and 1990 with stereotactic brachytherapy as part of their initial therapy. The treatment protocol involved surgery, partial brain external-beam radiotherapy, and stereotactic brachytherapy with temporary high-activity iodine 125 sources giving an additional 50 Gy to the tumor bed. Chemotherapy was not used in the initial management of these 35 patients. To compare our results with those obtained in a matched control group, we identified 40 patients with glioblastoma treated with surgery and external radiotherapy, with or without chemotherapy, between 1977 and 1986 at our institution. These patients had clinical and radiographic characteristics that would have made them eligible for the brachytherapy protocol. Survival rates at 1 and 2 years after diagnosis were 87% and 57%, respectively, for patients receiving brachytherapy versus 40% and 12.5%, respectively, for the controls (P less than .001). We conclude that stereotactic brachytherapy improves the survival of patients with glioblastoma when it can be incorporated into the initial treatment approach. Unfortunately, only about one in four patients with glioblastoma are suitable candidates for brachytherapy at the time of initial presentation

  5. Indications, techniques and results of postoperative brachytherapy in cancer of the oral cavity

    International Nuclear Information System (INIS)

    Purpose/objective: We tried to reduce the number of local recurrences after surgery and external beam irradiation (EBI) in carcinoma of the oral cavity, when margins were positive or close. Material and methods: From 1980 to 1992, we treated 97 cases of carcinomas of the oral cavity by postoperative brachytherapy. Surgery was combined with EBI+brachytherapy in 51 cases and with brachytherapy alone in 46 cases. We treated 29 T1, 34 T2, 30 T3T4 and four Tx (73% were N0 at first examination and 23% had positive nodes). The type of surgery is analysed. Brachytherapy was performed in one or two planes along the surgical scar. If the mandibular rim was resected, especially when the tongue or the remaining floor were sutured to the internal face of the inferior lip or to the buccal mucosa, the bridge technique was used. To decrease the dose to the inferior part of the mandible, the bridge was modified thanks to experimental dosimetry. Results: At 5 years, the local control (LC) is 89%, the locoregional control (LRC) 82%, the specific survival (SS) 74% and the overall survival (OS) 67%. Complications: We noted 19% of grade 1 (minor), 12% of grade 2 (moderate) and 6% of grade 3 (major) complications. Conclusion: Compared with the results of the literature, we think that postoperative brachytherapy can improve classical radiosurgical results in selected cases with a risk of local recurrence

  6. Techniques and results of brachytherapy for carcinoma of the tongue

    International Nuclear Information System (INIS)

    Three hundred and twelve patients with 1987 UICC T1, 2 carcinoma of the tongue, who underwent definitive brachytherapy from November, 1978 to March, 1991 in the Department of Radiology, Kyushu University Hospital, and from January, 1985 to December, 1994 in the Department of Radiotherapy, Kyushu Cancer Center, were reviewed retrospectively. All patients were admitted 15-30 mg Pentazocine and O.25 mg Atropine sulfate as the premedication. Thirty to 60 minutes after, the tip of tongue and the lesion were put under local infiltration anesthesia with 10-20 ml of 1-2% Lidocaine or 1% Procaine HCL. The tongue was pulled out by the thread of the tip. Partial resection or wide excisional biopsy of the tumor was performed to reduce the tumor volume and the radiation volume and also to estimate Jacobson-Yamamoto's grading histologically in the bottom of the tumor. Radium needles or Iridium hair pins were implanted in the lesion following Paterson's method, and left for 3-10 days to the minimum tumor dose of 70 Gy calculated by computer. The secondary neck lymph node metastases rates of the patients with T1 carcinoma of the tongue were 27% and 53% in the Jacobson-Yamamoto grading 1-3 group and 4 group. The rates of the patients with T2 were 28% and 82% in 1-3 group and 4 group. Two year's local control rates of the patients with T1 and T2 carcinoma were 95% and 82%. Two year's late reaction (mandibular bone exposure or refractory ulcer of soft tissue) rates of the patients with T1 and T2 carcinoma were 7% and 12%. (author)

  7. Clinical results of iridium-192 high dose rate brachytherapy with external beam radiotherapy

    International Nuclear Information System (INIS)

    Here, we report the clinical results of iridium-192 high dose rate brachytherapy at Kanazawa University Hospital. The study population consisted of 166 patients diagnosed with T1c-T3bN0M0 prostate cancer treated with high dose rate brachytherapy and external beam radiotherapy and followed up for 6 months or longer. Treatment consisted of external beam radiotherapy to the prostate at 44 Gy/22 fractions and high dose rate brachytherapy at 18 Gy/3 fractions. Median follow-up interval was 31.5 months (range 6.2-88.7). The overall 5-year biological recurrence-free survival rate was 93.0%. The 5-year biological recurrence-free survival rates for the patients in low-, intermediate- and high-risk groups according to the D'Amico risk classification criteria were 96.1%, 89.0% and 91.6%, respectively. When limited to the group that did not receive adjuvant hormonal therapy, the 5-year biological recurrence-free survival rates for the patients in low-, intermediate- and high-risk groups were 96.0%, 96.3% and 82.9%, respectively. Grade 3 or greater adverse effects were rare. Urethral stricture was observed in only 1.0% of the patients. Eighty percent of patients retained erectile function after high dose rate brachytherapy and reported satisfaction with sexual function. High dose rate brachytherapy is considered a good form of treatment for localized prostate cancer, although longer follow-up is necessary. (author)

  8. Retrospective study of the local control and the cosmetic result of 147 face carcinomas after interstitial brachytherapy

    International Nuclear Information System (INIS)

    The purpose was to evaluate retrospectively the local control rate and the cosmetic results for patients that received an interstitial brachytherapy for a base or spino-cellular carcinoma of face orifices areas. The interstitial brachytherapy by iridium 192 is an excellent alternative to surgery in the skin carcinomas of the face, as well at the level of local control as the cosmetic and functional results. (N.C.)

  9. EUPORIAS: plans and preliminary results

    Science.gov (United States)

    Buontempo, C.

    2013-12-01

    Recent advances in our understanding and ability to forecast climate variability have meant that skilful predictions are beginning to be routinely made on seasonal to decadal (s2d) timescales. Such forecasts have the potential to be of great value to a wide range of decision-making, where outcomes are strongly influenced by variations in the climate. In 2012 the European Commission funded EUPORIAS, a four year long project to develop prototype end-to-end climate impact prediction services operating on a seasonal to decadal timescale, and assess their value in informing decision-making. EUPORIAS commenced on 1 November 2012, coordinated by the UK Met Office leading a consortium of 24 organisations representing world-class European climate research and climate service centres, expertise in impacts assessments and seasonal predictions, two United Nations agencies, specialists in new media, and commercial companies in climate-vulnerable sectors such as energy, water and tourism. The poster describes the setup of the project, its main outcome and some of the very preliminary results.

  10. Preliminary results of ANAIS-25

    CERN Document Server

    Amaré, J; Cuesta, C; García, E; Ginestra, C; Martínez, M; Oliván, M A; Ortigoza, Y; de Solórzano, A Ortiz; Pobes, C; Puimedón, J; Sarsa, M L; Villar, P; Villar, J A

    2013-01-01

    The ANAIS (Annual Modulation with NaI(Tl) Scintillators) experiment aims at the confirmation of the DAMA/LIBRA signal using the same target and technique at the Canfranc Underground Laboratory. 250 kg of ultrapure NaI(Tl) crystals will be used as a target, divided into 20 modules, each coupled to two photomultipliers. Two NaI(Tl) crystals of 12.5 kg each, grown by Alpha Spectra from a powder having a potassium level under the limit of our analytical techniques, form the ANAIS-25 set-up. The background contributions are being carefully studied and preliminary results are presented: their natural potassium content in the bulk has been quantified, as well as the uranium and thorium radioactive chains presence in the bulk through the discrimination of the corresponding alpha events by PSA, and due to the fast commissioning, the contribution from cosmogenic activated isotopes is clearly identified and their decay observed along the first months of data taking. Following the procedures established with ANAIS-0 and ...

  11. Australasian brachytherapy audit: results of 'end-to-end' dosimetry pilot study

    International Nuclear Information System (INIS)

    We present the results of a pilot study to test the feasibility of a brachytherapy dosimetry audit. The feasibility study was conducted at seven sites from four Australian states in both public and private centres. A purpose-built cylindrical water phantom was imaged using the local imaging protocol and a treatment plan was generated to deliver 1Gy to the central (1 of 3) thermoluminescent dosimeter (TLD) from six dwell positions. All centres completed the audit, consisting of three consecutive irradiations, within a 2-h time period, with the exception of one centre that uses a pulsed dose rate brachytherapy unit. All TLD results were within 4.5% of the predicted value, with the exception of one subset where the dwell position step size was incorrectly applied. While the limited data collected in the study demonstrated considerable heterogeneity in clinical practice, the study proved a brachytherapy dosimetry audit to be feasible. Future studies should include verification of source strength using a Standard Dosimetry Laboratory calibrated chamber, a phantom that more closely mimics the clinical situation, a more comprehensive review of safety and quality assurance (QA) procedures including source dwell time and position accuracy, and a review of patient treatment QA procedures such as applicator position verification.

  12. Partial breast irradiation with interstitial high dose-rate brachytherapy: acute and late toxicities and cosmetic results

    International Nuclear Information System (INIS)

    Accelerated partial breast irradiation aims at decreasing the overall treatment time and reducing toxicity. The study we report is for early stage breast cancer and is a multicentre clinical investigation of partial breast irradiation achieved by interstitial high dose-rate (HDR) brachytherapy with intraoperative placement of catheters. We have been able to conclude from the initial data that an interstitial perioperative brachytherapy implant is a feasible method of treatment with good tolerance and good cosmetic results. (author)

  13. Preliminary Study on Palladium-103 Production By Neutron Activation Using G.A. Siwabessy Reactor For Brachytherapy Seed

    International Nuclear Information System (INIS)

    Palladium-103 (Pd-103) is one of the effective radionuclides for brachytherapy seed. Preliminary study on Palladium-103 production by calculations of Palladium irradiation in G.A. Siwabessy reactor has been carried out. The calculation was performed using natural and enriched Palladium metal with a length of 45 mm and a diameter of 0.8 mm at central irradiation position (neutron flux 1,3xl014 n.s-l.cm-2) and rabbit system (neutron flux 4xl013 n.s-1.cm-2). Calculation results showed that irradiation of natural Palladium at rabbit system for 12 hours resulted in Palladium-103 with radioactivity of 4.27 MBq at the end of irradiation (EOI), lower than the minimum radioactivity for seed (37 MBq). Irradiation of enriched Palladium (Pd-102 enrichment 89%) at rabbit system resulted in Pd-103 with radioactivity of 387 MBq at EOI. Radionuclide impurities of Pd-109 and Pd-111 were produced in the irradiation process. Radioactivity of Pd-111 decreased rapidly since the half life is very short (23.3 min). Radionuclide impurity of Pd-109 decreased to less that 0.1% of Pd-103 radioactivity after 6.3 days. The radioactivity of Pd-103 became 299 MBq 6.3 days after irradiation. Irradiation of natural Palladium at central irradiation position resulted in Pd-103 with radioactivity of 265 MBq at EOI. Radioactivity of Pd-109 was 4390 MBq at EOI and decreased to less than 0.1% of Pd-103 radioactivity after 8,3 days. The radioactivity of Pd-103 decreased to 189 MBq after the decay time. (author)

  14. A Multi-Institutional Study of Feasibility, Implementation, and Early Clinical Results With Noninvasive Breast Brachytherapy for Tumor Bed Boost

    International Nuclear Information System (INIS)

    Purpose: To evaluate the feasibility, implementation, and early results of noninvasive breast brachytherapy (NIBB) for tumor bed boost with whole breast radiation therapy (WBRT). Methods and Materials: NIBB is a commercially available (AccuBoost, Billerica, MA) mammography-based, brachytherapy system in which the treatment applicators are centered on the planning target volume (PTV) to direct 192Ir emissions along orthogonal axes. A privacy-encrypted online data registry collected information from 8 independent academic and community-based institutions. Data were from 146 consecutive women with early-stage breast cancer after lumpectomy and WBRT receiving boost with NIBB between July 2007 and March 2010. Toxicity and cosmesis were graded according to the Common Toxicity Criteria (v. 3.0) and the Harvard scale. Median follow-up was 6 months (1–39 months). Results: Grade 1–2 skin toxicity was observed in 64%, 48%, and 21% during the acute (1–3 weeks), intermediate (4–26 weeks), and late-intermediate (>26 weeks) periods. There was no Grade 4 toxicity. At 6 months, for the entire cohort, cosmesis was excellent/good in 62%/38%. The subset receiving NIBB before WBRT had cosmetic scores of 32% and 63%, whereas during WBRT, 58% and 37% were rated as excellent and good, respectively. Breast compression was scored as “uncomfortable” in 12%, 29%, and 59% when NIBB was delivered before, during, or after WBRT. For each patient, the fraction-to-fraction variability in PTV was low. Skin flash was associated with a higher proportion of excellent cosmesis (58% vs. 42%) relative to having the applicator all within breast tissue. Conclusions: These data indicate that NIBB is feasible and can be consistently implemented in a broad array of practice settings. Preliminary evaluation suggests that NIBB is associated with acceptably mild normal tissue toxicity and favorable early cosmesis. The application of NIBB before WBRT may be associated with better patient tolerance at

  15. Preliminary Results Towards Contract Monitorability

    OpenAIRE

    Vella, Annalizz; Francalanza, Adrian

    2016-01-01

    This paper discusses preliminary investigations on the monitorability of contracts for web service descriptions. There are settings where servers do not guarantee statically whether they satisfy some specified contract, which forces the client (i.e., the entity interacting with the server) to perform dynamic checks. This scenario may be viewed as an instance of Runtime Verification, where a pertinent question is whether contracts can be monitored for adequately at runtime, otherwise stated as...

  16. Reirradiation for recurrent head and neck cancer with salvage interstitial pulsed-dose-rate brachytherapy. Long-term results

    International Nuclear Information System (INIS)

    To assess the long-term results of protocol-based interstitial pulsed-dose-rate (PDR) brachytherapy as reirradiation combined with simultaneous chemotherapy and interstitial hyperthermia in selected patients with recurrent head and neck tumors. A total of 104 patients with biopsy-proven recurrent head and neck cancer were treated with interstitial PDR brachytherapy. Salvage surgery had also been undergone by 53/104 (51 %) patients (R1 or R2 resection in > 80 % of patients). Salvage brachytherapy alone was administered in 81 patients (78 %), with a median total dose of 56.7 Gy. Salvage brachytherapy in combination with external beam radiotherapy (EBRT) was performed in 23/104 patients (32 %), using a median total dose of DREF = 24 Gy. Simultaneously to PDR brachytherapy, concomitant chemotherapy was administered in 58/104 (55.8 %) patients. A single session of interstitial hyperthermia was also used to treat 33/104 (31.7 %) patients. The analysis was performed after a median follow-up of 60 months. Calculated according to Kaplan-Meier, local tumor control rates after 2, 5, and 10 years were 92.5, 82.4, and 58.9 %, respectively. Comparing results of salvage PDR brachytherapy with or without simultaneous chemotherapy, the 10-year local control rates were 76 vs. 39 % (p= 0014), respectively. No other patient- or treatment-related parameters had a significant influence on treatment results. Soft tissue necrosis or bone necrosis developed in 18/104 (17.3 %) and 11/104 (9.6 %) patients, respectively, but only 3 % of patients required surgical treatment. PDR interstitial brachytherapy with simultaneous chemotherapy is a very effective and, in experienced hands, also a safe treatment modality in selected patients with head and neck cancer in previously irradiated areas. (orig.)

  17. Preliminary report of pulsed dose rate brachytherapy in head-and-neck cancer

    Energy Technology Data Exchange (ETDEWEB)

    Ziemlewski, A.; Zienkiewicz, J. [Medical Univ. of Gdansk (Poland). Dept. of Oral and Maxillofacial Surgery; Serkies, K.; Badzio, A. [Medical Univ. of Gdansk (Poland). Dept. of Oncology and Radiotherapy

    2007-09-15

    Purpose: To assess the feasibility and acute/delayed toxicity of pulsed-dose-rate brachytherapy (PDR BT) in head-and-neck tumors. Patients and Methods: 45 head and neck cancer patients underwent interstitial or contact PDR BT at a dose of 10.2-70 Gy (median, 70 Gy) and 0.6 or 1.0 Gy/pulse/h. 42 patients were administered BT as part of their curative treatment; 32 of them had sole BT. Three reirradiated patients with recurrent tumor had palliative BT. Results: PDR BT was well tolerated. Intense bleeding was the only complication associated with catheter removal from the tongue and bucca. 44 patients who completed BT experienced acute mucositis. Grade 3 toxicity of skin and oral mucosa occurred in three (6.8%) and six patients (13.6%), respectively. At a median follow-up of 22 months (range, 2-67 months), late serious toxicity (grade 4, for soft tissue and bone) was seen in seven patients (15.9%). Among the parameters analyzed, only dental care performed before BT had a significant impact on mucosal side effects. Acute severe mucositis was observed in 23% of patients without dental care compared to 0% of those with dental care (p = 0.044). Late severe mucositis occurred in 17.7% and 26.9% of the respective patients (p = 0.035), overall in 23%. The larger the volume encompassed by the reference isodose, the more late (p = 0.004) mucosal reactions were observed. Conclusion: PDR BT continued over a few days is a feasible and safe approach in head-and-neck tumors; however, it is accompanied by some toxicity. Dental care should precede isotope application. (orig.)

  18. Cosmetic results in early stage breast cancer patients with high-dose brachytherapy after conservative surgery

    International Nuclear Information System (INIS)

    Purpose: to reveal cosmetic results in patients at early stages of low risk breast cancer treated with partial accelerated radiotherapy using high dose rate brachytherapy. Methods and materials: from March 2001 to July 2003,14 stages l and ll breast cancer patients were treated at the Colombian national cancer institute in Bogota with conservative surgery and radiotherapy upon the tumor bed (partial accelerated radiotherapy), using interstitial implants with iridium 192 (high dose rate brachytherapy) with a dose of 32 Gys, over 4 days, at 8 fractions twice a day. Results: with an average follow up of 17.7 months, good cosmetic results were found among 71.4 % of patients and excellent results among 14.3% of patients, furthermore none of the patients neither local nor regional or distant relapses. Conclusion: among patients who suffer from breast cancer at early stages, it showed is possible to apply partial accelerated radiotherapy upon the tumor bed with high doses over 4 days with good to excellent cosmetic results

  19. Reirradiation for recurrent head and neck cancer with salvage interstitial pulsed-dose-rate brachytherapy. Long-term results

    Energy Technology Data Exchange (ETDEWEB)

    Strnad, Vratislav; Lotter, Michael; Kreppner, Stephan; Fietkau, Rainer [University Hospital Erlangen, Dept. of Radiation Oncology, Erlangen (Germany)

    2015-01-10

    To assess the long-term results of protocol-based interstitial pulsed-dose-rate (PDR) brachytherapy as reirradiation combined with simultaneous chemotherapy and interstitial hyperthermia in selected patients with recurrent head and neck tumors. A total of 104 patients with biopsy-proven recurrent head and neck cancer were treated with interstitial PDR brachytherapy. Salvage surgery had also been undergone by 53/104 (51 %) patients (R1 or R2 resection in > 80 % of patients). Salvage brachytherapy alone was administered in 81 patients (78 %), with a median total dose of 56.7 Gy. Salvage brachytherapy in combination with external beam radiotherapy (EBRT) was performed in 23/104 patients (32 %), using a median total dose of D{sub REF} = 24 Gy. Simultaneously to PDR brachytherapy, concomitant chemotherapy was administered in 58/104 (55.8 %) patients. A single session of interstitial hyperthermia was also used to treat 33/104 (31.7 %) patients. The analysis was performed after a median follow-up of 60 months. Calculated according to Kaplan-Meier, local tumor control rates after 2, 5, and 10 years were 92.5, 82.4, and 58.9 %, respectively. Comparing results of salvage PDR brachytherapy with or without simultaneous chemotherapy, the 10-year local control rates were 76 vs. 39 % (p= 0014), respectively. No other patient- or treatment-related parameters had a significant influence on treatment results. Soft tissue necrosis or bone necrosis developed in 18/104 (17.3 %) and 11/104 (9.6 %) patients, respectively, but only 3 % of patients required surgical treatment. PDR interstitial brachytherapy with simultaneous chemotherapy is a very effective and, in experienced hands, also a safe treatment modality in selected patients with head and neck cancer in previously irradiated areas. (orig.) [German] Es erfolgte die Analyse der Langzeitergebnisse einer protokollbasierten interstitiellen Brachytherapie (Re-Bestrahlung) mit simultaner Chemotherapie und interstitieller Hyperthermie

  20. Computer simulation of fractionated radiotherapy: Further results and their relevance to percutaneous irradiation and brachytherapy

    International Nuclear Information System (INIS)

    Basing on previous papers, the present communication considers the simulation of the radiotherapeutic treatments of glioblastoma multiforme, rectum adenocarcinoma, and gynaecological tumors of cervix uteri (squamous and adenocarcinoma) in spheroid culture. Starting with a single tumor cell in a nutrient medium and after the corresponding growth of the tumor spheroids, varying irradiation schemes are applied to the carcinoma and are compared with regard to tumor kill effectivity using the LQ-model. The two first-mentioned carcinoma are exposed to the dose fractionation schemes standard-, super-, hyperfractionation, and weekly high single dose. The result is that hyperfractionation (3x1.5 Gy/day) and weekly high single dose (1x6 Gy/week) yield the most effective tumor cell kill. The weekly high single dose may be realized by some different irradiation techniques, e.g. stereotactic irradiation or interstitial high dose rate brachytherapy. The treatment of the cervix uteri tumors is performed by a combined therapy form (high dose rate brachytherapy and percutaneous irradition). A comparing simulation of two typical regimens yield a nearly equivalent tumor kill effectivity. By the integration of in vitro tumor growth and clinical treatment schemes in a computer model, the possibility is made available to test the effectivity of variable regimens with the help of computer experiments. (orig.)

  1. Spectral CT evaluation of interstitial brachytherapy in pancreatic carcinoma xenografts: preliminary animal experience

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Shudong [Jiangsu University, Department of Radiology, The Affiliated Renmin Hospital, Zhenjiang, Jiangsu (China); Shanghai Jiao tong University, School of Medicine, Department of Radiology, Ruijin Hospital, Shanghai (China); Huang, Wei; Song, Qi; Lin, Xiaozhu; Wang, Zhongmin; Chen, Kemin [Shanghai Jiao tong University, School of Medicine, Department of Radiology, Ruijin Hospital, Shanghai (China); Chen, Yerong [Jiangsu University, Department of Radiology, The Affiliated Renmin Hospital, Zhenjiang, Jiangsu (China)

    2014-09-15

    We sought to evaluate the capability of spectral CT to detect the therapeutic response to {sup 125}I interstitial brachytherapy in a pancreatic carcinoma xenograft nude mouse model. Twenty mice bearing SWl990 human pancreatic cancer cell xenografts were randomly separated into two groups: experimental (n = 10; 1.0 mCi) and control (n = 10; 0 mCi). After a two-week treatment, spectral CT was performed. Contrast-to-noise ratio (CNR) and iodine concentration (IC) in the lesions were measured and normalized to the muscle tissue, and nIC CD31 immunohistochemistry was used to measure microvessel density (MVD). The relationships between the nIC and MVD of the tumours were analysed. The nIC of the experimental group was significantly lower than that of the control group during the multiphase examination. A significant difference in the MVD was observed between the two groups (P <0.001). The nIC values of the three-phase scans have a certain positive correlation with MVD (r = 0.57, p < 0.0001; r = 0.48, p = 0.002; r = 0.63, p = 0.0017 in the 10, 25, and 60 s phase, respectively). Spectral CT can be a useful non-invasive imaging modality in evaluating the therapeutic effect of {sup 125}I interstitial brachytherapy to a pancreatic carcinoma. (orig.)

  2. Low-dose-rate brachytherapy for patients with transurethral resection before implantation in prostate cancer: long-term results

    Energy Technology Data Exchange (ETDEWEB)

    Prada, Pedro J.; Anchuelo, Javier; Blanco, Ana Garcia; Paya, Gema; Cardenal, Juan; Acuña, Enrique; Ferri, Maria [Department of Radiation Oncology, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria (Spain); Vazquez, Andres; Pacheco, Maite; Sanchez, Jesica [Department of Radiation Physics, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria (Spain)

    2016-01-15

    Objectives: We analyzed the long-term oncologic outcome for patients with prostate cancer and transurethral resection who were treated using low-dose-rate (LDR) prostate brachytherapy. Methods and Materials: From January 2001 to December 2005, 57 consecutive patients were treated with clinically localized prostate cancer. No patients received external beam radiation. All of them underwent LDR prostate brachytherapy. Biochemical failure was defined according to the 'Phoenix consensus'. Patients were stratified as low and intermediate risk based on The Memorial Sloan Kettering group definition. Results: The median follow-up time for these 57 patients was 104 months. The overall survival according to Kaplan-Meier estimates was 88% (±6%) at 5 years and 77% (±6%) at 12 years. The 5 and 10 years for failure in tumour-free survival (TFS) was 96% and respectively (±2%), whereas for biochemical control was 94% and respectively (±3%) at 5 and 10 years, 98% (±1%) of patients being free of local recurrence. A patient reported incontinence after treatment (1.7%). The chronic genitourinary complains grade I were 7% and grade II, 10%. At six months 94% of patients reported no change in bowel function. Conclusions: The excellent long-term results and low morbidity presented, as well as the many advantages of prostate brachytherapy over other treatments, demonstrates that brachytherapy is an effective treatment for patients with transurethral resection and clinical organ-confined prostate cancer. (author)

  3. Rare earth optogalvanic spectroscopy: preliminary results

    International Nuclear Information System (INIS)

    The IEAv has special interest in the studies of rare earth isotope applications in laser medium and integrated optics as well as aerospace research. We are starting to work with Ytterbium, Erbium, Dysprosium and Neodymium laser selective photoionization research. This paper describes the preliminary results of emission and optogalvanic spectroscopy obtained from a Neodymium hollow cathode lamps. Furthermore these results were used to setup our laser systems to work to leads a Nd isotopes selective laser photoionization. (author)

  4. In vivo dosimetry HDR brachytherapy prostate with source CO-60: Results of measures in a point urethra

    International Nuclear Information System (INIS)

    In this study we present and analyze the results of the in vivo dosimetry made a point of urethra with a group of 30 patients treated with brachytherapy prostate high rate with Co-60 source. Taking into account the uncertainties, the results and integration, globally evaluate this system DIV. This DIV system, due to its ease of calibration and use, and provides a relatively simple integration way to avoid serious errors in administering treatment. (Author)

  5. Long-Term Results From the Contura Multilumen Balloon Breast Brachytherapy Catheter Phase 4 Registry Trial

    International Nuclear Information System (INIS)

    Purpose: To describe the long-term outcomes from a completed, multi-institutional phase 4 registry trial using the Contura multilumen balloon (CMLB) breast brachytherapy catheter to deliver accelerated partial breast irradiation (APBI) in patients with early-stage breast cancer. Methods and Materials: Three hundred forty-two evaluable patients were enrolled by 23 institutions between January 2008 and February 2011. All patients received 34 Gy in 10 fractions, delivered twice daily. Rigorous target coverage and normal tissue dose constraints were observed. Results: The median follow-up time was 36 months (range, 1-54 months). For the entire patient cohort of 342 patients, 10 patients experienced an ipsilateral breast tumor recurrence (IBTR). Eight of these IBTR were classified as true recurrences/marginal miss (TRMM), and 2 were elsewhere failures (EF). Local recurrence-free survival was 97.8% at 3 years. For the entire cohort, 88% of patients had good to excellent overall cosmesis. The overall incidence of infection was 8.5%. Symptomatic seroma was reported in only 4.4% of patients. A separate analysis was performed to determine whether improved outcomes would be observed for patients treated at high-volume centers with extensive brachytherapy experience. Three IBTR were observed in this cohort, only 1 of which was classified as a TRMM. Local recurrence-free survival at high-volume centers was 98.1% at 3 years. Overall cosmetic outcome and toxicity were superior in patients treated at high-volume centers. In these patients, 95% had good to excellent overall cosmesis. Infection was observed in only 2.9% of patients, and symptomatic seroma was reported in only 1.9%. Conclusion: Use of the CMLB for APBI delivery is associated with acceptable long-term local control and toxicity. Local recurrence-free survival was 97.8% at 3 years. Significant (grade 3) toxicity was uncommon, and no grade 4 toxicity was observed. Treatment at high-volume centers was associated

  6. Long-Term Results From the Contura Multilumen Balloon Breast Brachytherapy Catheter Phase 4 Registry Trial

    Energy Technology Data Exchange (ETDEWEB)

    Cuttino, Laurie W., E-mail: lcuttino@mcvh-vcu.edu [Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia (United States); Arthur, Douglas W. [Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia (United States); Vicini, Frank [Michigan Healthcare Professionals/21st Century Onoclogy, Farmington Hills, Michigan (United States); Todor, Dorin [Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia (United States); Julian, Thomas [Allegheny Hospital, Temple School of Medicine, Pittsburgh, Pennsylvania (United States); Mukhopadhyay, Nitai [Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia (United States)

    2014-12-01

    Purpose: To describe the long-term outcomes from a completed, multi-institutional phase 4 registry trial using the Contura multilumen balloon (CMLB) breast brachytherapy catheter to deliver accelerated partial breast irradiation (APBI) in patients with early-stage breast cancer. Methods and Materials: Three hundred forty-two evaluable patients were enrolled by 23 institutions between January 2008 and February 2011. All patients received 34 Gy in 10 fractions, delivered twice daily. Rigorous target coverage and normal tissue dose constraints were observed. Results: The median follow-up time was 36 months (range, 1-54 months). For the entire patient cohort of 342 patients, 10 patients experienced an ipsilateral breast tumor recurrence (IBTR). Eight of these IBTR were classified as true recurrences/marginal miss (TRMM), and 2 were elsewhere failures (EF). Local recurrence-free survival was 97.8% at 3 years. For the entire cohort, 88% of patients had good to excellent overall cosmesis. The overall incidence of infection was 8.5%. Symptomatic seroma was reported in only 4.4% of patients. A separate analysis was performed to determine whether improved outcomes would be observed for patients treated at high-volume centers with extensive brachytherapy experience. Three IBTR were observed in this cohort, only 1 of which was classified as a TRMM. Local recurrence-free survival at high-volume centers was 98.1% at 3 years. Overall cosmetic outcome and toxicity were superior in patients treated at high-volume centers. In these patients, 95% had good to excellent overall cosmesis. Infection was observed in only 2.9% of patients, and symptomatic seroma was reported in only 1.9%. Conclusion: Use of the CMLB for APBI delivery is associated with acceptable long-term local control and toxicity. Local recurrence-free survival was 97.8% at 3 years. Significant (grade 3) toxicity was uncommon, and no grade 4 toxicity was observed. Treatment at high-volume centers was associated

  7. CT-guided interstitial HDR brachytherapy for recurrent glioblastoma multiforme. Long-term results

    Energy Technology Data Exchange (ETDEWEB)

    Tselis, N.; Roeddiger, S.; Filipowicz, I.; Kontova, M.; Heyd, R.; Zamboglou, N. [Offenbach Hospital (Germany). Dept. of Radiotherapy and Interdisciplinary Oncology; Kolotas, C. [Offenbach Hospital (Germany). Dept. of Radiotherapy and Interdisciplinary Oncology; Hirslanden Medical Center, Aarau (Switzerland). Inst. of Radiotherapy; Birn, G. [Offenbach Hospital (Germany). Dept. of Neurosurgery; Fountzilas, G.; Selviaridis, P. [Aristotle Univ. of Thessaloniki School of Medicine, Thessaloniki (Greece); Baltas, D.; Anagnostopoulos, G. [Offenbach Hospital (Germany). Dept. of Medical Physics and Engineering

    2007-10-15

    Background and Purpose: Recurrences of glioblastoma multiforme (GBM) within previously irradiated volumes pose a serious therapeutic challenge. This retrospective study evaluates the long-term tumor control of recurrent GBM treated with interstitial high-dose-rate brachytherapy (HDR-BRT). Patients and Methods: Between 1995 and 2003, 84 patients were treated for recurrent cerebral GBM located within previously irradiated volumes. All patients had received adjuvant external radiotherapy following primary surgery, with a focal dose up to 60 Gy. The median recurrent tumor volume was 51 cm{sup 3} (3-207 cm{sup 3}), and the HDR-BRT consisted of an afterloading {sup 192}Ir implant which delivered a median dose of 40 Gy (30-50 Gy). Catheter implantation was implemented using interactive computed tomography (CT) guidance under local anesthesia and sedoanalgesia. Results: After a median follow-up of 61 months, 5/84 patients (6%) were alive. The median post-BRT survival was 37 weeks, and the median overall survival 78 weeks. Moderate to severe complications occurred in 5/84 cases (6%). Conclusion: For patients with recurrences of GBM within previously irradiated volumes, CT-guided interstitial HDR-BRT is a feasible treatment option that can play an important role in providing palliation. (orig.)

  8. Long-term results of curative intraluminal high dose rate brachytherapy for endobronchial carcinoma

    International Nuclear Information System (INIS)

    The treatment strategy of central lung tumors is not established. Intraluminal brachytherapy (ILBT) is widely used for palliative treatment of endobronchial tumors, however, it is also a promising option for curative treatment with limited data. This study evaluates the results after ILBT for endobronchial carcinoma. Sixteen-endobronchial carcinoma of 13 patients treated with ILBT in curative intent for 2000 to 2008 were retrospectively reviewed. ILBT using high dose rate 192 iridium thin wire system was performed with 5 Gy/fraction at mucosal surface. The patient age ranged from 57 to 82 years old with median 75 years old. The 16 lesions consisted of 13 central endobronchial cancers including 7 roentgenographically occult lung cancers and 3 of tracheal cancers. Of them, 10 lesions were treated with ILBT of median 20 Gy combined with external beam radiation therapy of median 45 Gy and 6 lesions were treated with ILBT alone of median 25 Gy. Median follow-up time was 32.5 months. Two-year survival rate and local control rate were 92.3% and 86.2%, respectively. Local recurrences were observed in 2 lesions. Three patients died due to lung cancer (1 patient) and intercurrent disease (2 patients). Complications greater than grade 2 were not observed except for one grade 3 dyspnea. ILBT combined with or without EBRT might be a curative treatment option in inoperable endobronchial carcinoma patients with tolerable complication

  9. Conservative treatment of anal canal carcinoma with external radiotherapy and interstitial brachytherapy, with or without chemotherapy: long-term results

    International Nuclear Information System (INIS)

    Purpose: a retrospective analysis of conservative treatment of anal canal cancers with external radiation therapy and interstitial brachytherapy with or without chemotherapy. Patients and methods: from 1986 to 1996, 69 patients were treated with external radiotherapy (40 Gy/20 fractions) and interstitial brachytherapy (20 Gy) after a mean interval of six weeks for a localized epidermoid carcinoma of the anal canal. Patients who did not complete the whole therapeutic sequence were not included. Forty-five patients received additional 5-fluorouracil- and/or mitomycin C-based chemotherapy regimen. Results: acute toxicity was acceptable. Complete response rate was 81%. Actuarial local control rate was at two and five years, 65% and 59% respectively (median follow-up: eight years). At two, five and ten years, actuarial colostomy rate was 26%, 33% and 33% respectively, and colostomy-free survival rates 61%, 47% and 37%. Overall survival at two, five and ten years was 81%, 65% and 53% respectively. Distant metastases occurred in 11 patients (16%). Prognostic factors for overall survival were performance status (PS) (79% survival at five years for patients with PS 0 versus 50% for patients with PS 1-3, P = 0.04) and tumor stage (80% at five years for T1-T2 versus 53% for T3-T4, P = 0.03). Overall treatment time less than 12 weeks and time interval between external radiotherapy and brachytherapy inferior than six weeks were associated with a better local control (P = 0.05). In multivariate analysis, these prognostic factors were not significant. Conclusion: these results confirm the efficacy of external radiotherapy and brachytherapy in the treatment of small anal canal cancers, and point out the need for improving treatment outcome of larger tumors. (author)

  10. Long-term results of curative intraluminal high dose rate brachytherapy for endobronchial carcinoma

    Directory of Open Access Journals (Sweden)

    Kawamura Hidemasa

    2012-07-01

    Full Text Available Abstract Background The treatment strategy of central lung tumors is not established. Intraluminal brachytherapy (ILBT is widely used for palliative treatment of endobronchial tumors, however, it is also a promising option for curative treatment with limited data. This study evaluates the results after ILBT for endobronchial carcinoma. Method Sixteen-endobronchial carcinoma of 13 patients treated with ILBT in curative intent for 2000 to 2008 were retrospectively reviewed. ILBT using high dose rate 192 iridium thin wire system was performed with 5 Gy/fraction at mucosal surface. The patient age ranged from 57 to 82 years old with median 75 years old. The 16 lesions consisted of 13 central endobronchial cancers including 7 roentgenographically occult lung cancers and 3 of tracheal cancers. Of them, 10 lesions were treated with ILBT of median 20 Gy combined with external beam radiation therapy of median 45 Gy and 6 lesions were treated with ILBT alone of median 25 Gy. Results Median follow-up time was 32.5 months. Two-year survival rate and local control rate were 92.3% and 86.2%, respectively. Local recurrences were observed in 2 lesions. Three patients died due to lung cancer (1 patient and intercurrent disease (2 patients. Complications greater than grade 2 were not observed except for one grade 3 dyspnea. Conclusions ILBT combined with or without EBRT might be a curative treatment option in inoperable endobronchial carcinoma patients with tolerable complication.

  11. Conventional Versus Automated Implantation of Loose Seeds in Prostate Brachytherapy: Analysis of Dosimetric and Clinical Results

    Energy Technology Data Exchange (ETDEWEB)

    Genebes, Caroline, E-mail: genebes.caroline@claudiusregaud.fr [Radiation Oncology Department, Institut Claudius Regaud, Toulouse (France); Filleron, Thomas; Graff, Pierre [Radiation Oncology Department, Institut Claudius Regaud, Toulouse (France); Jonca, Frédéric [Department of Urology, Clinique Ambroise Paré, Toulouse (France); Huyghe, Eric; Thoulouzan, Matthieu; Soulie, Michel; Malavaud, Bernard [Department of Urology and Andrology, CHU Rangueil, Toulouse (France); Aziza, Richard; Brun, Thomas; Delannes, Martine; Bachaud, Jean-Marc [Radiation Oncology Department, Institut Claudius Regaud, Toulouse (France)

    2013-11-15

    Purpose: To review the clinical outcome of I-125 permanent prostate brachytherapy (PPB) for low-risk and intermediate-risk prostate cancer and to compare 2 techniques of loose-seed implantation. Methods and Materials: 574 consecutive patients underwent I-125 PPB for low-risk and intermediate-risk prostate cancer between 2000 and 2008. Two successive techniques were used: conventional implantation from 2000 to 2004 and automated implantation (Nucletron, FIRST system) from 2004 to 2008. Dosimetric and biochemical recurrence-free (bNED) survival results were reported and compared for the 2 techniques. Univariate and multivariate analysis researched independent predictors for bNED survival. Results: 419 (73%) and 155 (27%) patients with low-risk and intermediate-risk disease, respectively, were treated (median follow-up time, 69.3 months). The 60-month bNED survival rates were 95.2% and 85.7%, respectively, for patients with low-risk and intermediate-risk disease (P=.04). In univariate analysis, patients treated with automated implantation had worse bNED survival rates than did those treated with conventional implantation (P<.0001). By day 30, patients treated with automated implantation showed lower values of dose delivered to 90% of prostate volume (D90) and volume of prostate receiving 100% of prescribed dose (V100). In multivariate analysis, implantation technique, Gleason score, and V100 on day 30 were independent predictors of recurrence-free status. Grade 3 urethritis and urinary incontinence were observed in 2.6% and 1.6% of the cohort, respectively, with no significant differences between the 2 techniques. No grade 3 proctitis was observed. Conclusion: Satisfactory 60-month bNED survival rates (93.1%) and acceptable toxicity (grade 3 urethritis <3%) were achieved by loose-seed implantation. Automated implantation was associated with worse dosimetric and bNED survival outcomes.

  12. Preliminary results of ground-motion characteristics

    Directory of Open Access Journals (Sweden)

    Francesca Bozzoni

    2012-10-01

    Full Text Available The preliminary results are presented herein for the engineering applications of the characteristics of the ground motion induced by the May 20, 2012, Emilia earthquake. Shake maps are computed to provide estimates of the spatial distribution of the induced ground motion. The signals recorded at the Mirandola (MRN station, the closest to the epicenter, have been processed to obtain acceleration, velocity and displacement response spectra. Ground-motion parameters from the MRN recordings are compared with the corresponding estimates from recent ground-motion prediction equations, and with the spectra prescribed by the current Italian Building Code for different return periods. The records from the MRN station are used to plot the particle orbit (hodogram described by the waveform. The availability of results from geotechnical field tests that were performed at a few sites in the Municipality of Mirandola prior to this earthquake of May 2012 has allowed preliminary assessment of the ground response. The amplification effects at Mirandola are estimated using fully stochastic site-response analyses. The seismic input comprises seven actual records that are compatible with the Italian code-based spectrum that refers to a 475-year return period. The computed acceleration response spectrum and the associated dispersion are compared to the spectra calculated from the recordings of the MRN station. Good agreement is obtained for periods up to 1 s, especially for the peak ground acceleration. For the other periods, the spectral acceleration of the MRN recordings exceeds that of the computed spectra.

  13. Breakthrough propulsion physics workshop preliminary results

    International Nuclear Information System (INIS)

    In August, 1997, a NASA workshop was held to assess the prospects emerging from physics that might lead to creating the ultimate breakthroughs in space transportation: propulsion that requires no propellant mass, attaining the maximum transit speeds physically possible, and breakthrough methods of energy production to power such devices. Because these propulsion goals are presumably far from fruition, a special emphasis was to identify affordable, near-term, and credible research that could make measurable progress toward these propulsion goals. Experiments and theories were discussed regarding the coupling of gravity and electromagnetism, vacuum fluctuation energy, warp drives and wormholes, and superluminal quantum tunneling. Preliminary results of this workshop are presented, along with the status of the Breakthrough Propulsion Physics program that conducted this workshop

  14. Breakthrough Propulsion Physics Workshop Preliminary Results

    Science.gov (United States)

    Millis, Marc G.

    1997-01-01

    In August, 1997, a NASA workshop was held to assess the prospects emerging from physics that might lead to creating the ultimate breakthroughs in space transportation: propulsion that requires no propellant mass, attaining the maximum transit speeds physically possible, and breakthrough methods of energy production to power such devices. Because these propulsion goals are presumably far from fruition, a special emphasis was to identify affordable, near-term, and credible research that could make measurable progress toward these propulsion goals. Experiments and theories were discussed regarding the coupling of gravity and electromagnetism, vacuum fluctuation energy, warp drives and wormholes, and superluminal quantum tunneling. Preliminary results of this workshop are presented, along with the status of the Breakthrough Propulsion Physics program that conducted this workshop.

  15. Clinical results of Intracoronary Brachytherapy (ICBT) for multiple in-stent restenosis

    Energy Technology Data Exchange (ETDEWEB)

    Stadler, P. [Dept. of Radiotherapy and Radiation Oncology, Univ. Hospital Regensburg (Germany); Praxis Muehleninsel, Landshut-Muehldorf-Dingolfing (Germany); Schaefer, C.; Chaber, S.; Putnik, K.; Treutwein, M.; Koelbl, O. [Dept. of Radiotherapy and Radiation Oncology, Univ. Hospital Regensburg (Germany); Muders, F. [Dept. of Cardiology, Univ. Hospital Regensburg (Germany)

    2006-06-15

    Background and purpose: treatment of in-stent restenosis (ISR) with percutaneous coronary intervention (PCI) alone is often followed by early re-restenosis. The present study focused on the effect of intracoronary brachytherapy (ICBT) on multiple in-stent restenosis (MISR) after repeated PCI. Patients and methods: 40 patients (27 male, 13 female, age: 66 {+-} 9 years) with MISR (two to six ISRs, median three ISRs) were retrospectively analyzed. All patients were treated by using the Novoste {sup registered} Beta-Cath trademark 3.5F System after PCI. The target vessel received 18.4-25.3 Gy of radiation at a depth of 2 mm from the center of the source. The restenosis-free survival and overall survival were calculated by Kaplan-Meier analysis (log-rank). The time interval between last PCI without ICBT and the consecutive recurrence was compared with the follow-up time after PCI with ICBT. Results: the 3-year overall survival rate after ICBT was 93%. The 0.5-, 1-, 2-, and 3-year ISR-free survival rates after PCI + ICBT were 81%, 72%, 52%, and 38%, respectively. After PCI alone, the 0.5-, 1-, and 2-year ISR-free survival rates were 30%, 13%, and 0%, respectively. This difference was highly significant (p < 0.0001). Patients with more than three ISRs before ICBT had a better outcome (3-year ISR-free survival: 80%) than patients with only two or three ISRs before ICBT (3-year ISR-free survival: 25%; p < 0.05). Conclusion: ICBT is highly effective and safe in patients with ISR. The results of this study are in accordance with the WRIST and BETA-WRIST data. After 6 months both studies revealed an ISR-free survival rate of 86% (WRIST) and 66% (BETA-WRIST), respectively. The ISR rates in the own control group (70%) were comparable to the placebo groups in WRIST (68%) and BETA-WRIST (72%). Interestingly, patients with more than three ISRs before ICBT had the lowest ISR rate after ICBT. (orig.)

  16. Long-Term Results of a Randomized Trial in Locally Advanced Rectal Cancer: No Benefit From Adding a Brachytherapy Boost

    International Nuclear Information System (INIS)

    Purpose/Objective(s): Mature data on tumor control and survival are presented from a randomized trial of the addition of a brachytherapy boost to long-course neoadjuvant chemoradiation therapy (CRT) for locally advanced rectal cancer. Methods and Materials: Between March 2005 and November 2008, 248 patients with T3-4N0-2M0 rectal cancer were prospectively randomized to either long-course preoperative CRT (50.4 Gy in 28 fractions, per oral tegafur-uracil and L-leucovorin) alone or the same CRT schedule plus a brachytherapy boost (10 Gy in 2 fractions). The primary trial endpoint was pathologic complete response (pCR) at the time of surgery; secondary endpoints included overall survival (OS), progression-free survival (PFS), and freedom from locoregional failure. Results: Results for the primary endpoint have previously been reported. This analysis presents survival data for the 224 patients in the Danish part of the trial. In all, 221 patients (111 control arm, 110 brachytherapy boost arm) had data available for analysis, with a median follow-up time of 5.4 years. Despite a significant increase in tumor response at the time of surgery, no differences in 5-year OS (70.6% vs 63.6%, hazard ratio [HR] = 1.24, P=.34) and PFS (63.9% vs 52.0%, HR=1.22, P=.32) were observed. Freedom from locoregional failure at 5 years were 93.9% and 85.7% (HR=2.60, P=.06) in the standard and in the brachytherapy arms, respectively. There was no difference in the prevalence of stoma. Explorative analysis based on stratification for tumor regression grade and resection margin status indicated the presence of response migration. Conclusions: Despite increased pathologic tumor regression at the time of surgery, we observed no benefit on late outcome. Improved tumor regression does not necessarily lead to a relevant clinical benefit when the neoadjuvant treatment is followed by high-quality surgery

  17. Long-Term Results of a Randomized Trial in Locally Advanced Rectal Cancer: No Benefit From Adding a Brachytherapy Boost

    Energy Technology Data Exchange (ETDEWEB)

    Appelt, Ane L., E-mail: ane.lindegaard.appelt@rsyd.dk [Department of Oncology, Vejle Hospital, Vejle (Denmark); Faculty of Health Sciences, University of Southern Denmark, Odense (Denmark); Vogelius, Ivan R. [Department of Radiation Oncology, Rigshospitalet, University of Copenhagen, Copenhagen (Denmark); Pløen, John; Rafaelsen, Søren R.; Lindebjerg, Jan; Havelund, Birgitte M. [Danish Colorectal Cancer Group South, Vejle Hospital, Vejle (Denmark); Bentzen, Søren M. [Division of Biostatistics and Bioinformatics, University of Maryland Greenebaum Cancer Center, and Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland (United States); Jakobsen, Anders [Faculty of Health Sciences, University of Southern Denmark, Odense (Denmark); Danish Colorectal Cancer Group South, Vejle Hospital, Vejle (Denmark)

    2014-09-01

    Purpose/Objective(s): Mature data on tumor control and survival are presented from a randomized trial of the addition of a brachytherapy boost to long-course neoadjuvant chemoradiation therapy (CRT) for locally advanced rectal cancer. Methods and Materials: Between March 2005 and November 2008, 248 patients with T3-4N0-2M0 rectal cancer were prospectively randomized to either long-course preoperative CRT (50.4 Gy in 28 fractions, per oral tegafur-uracil and L-leucovorin) alone or the same CRT schedule plus a brachytherapy boost (10 Gy in 2 fractions). The primary trial endpoint was pathologic complete response (pCR) at the time of surgery; secondary endpoints included overall survival (OS), progression-free survival (PFS), and freedom from locoregional failure. Results: Results for the primary endpoint have previously been reported. This analysis presents survival data for the 224 patients in the Danish part of the trial. In all, 221 patients (111 control arm, 110 brachytherapy boost arm) had data available for analysis, with a median follow-up time of 5.4 years. Despite a significant increase in tumor response at the time of surgery, no differences in 5-year OS (70.6% vs 63.6%, hazard ratio [HR] = 1.24, P=.34) and PFS (63.9% vs 52.0%, HR=1.22, P=.32) were observed. Freedom from locoregional failure at 5 years were 93.9% and 85.7% (HR=2.60, P=.06) in the standard and in the brachytherapy arms, respectively. There was no difference in the prevalence of stoma. Explorative analysis based on stratification for tumor regression grade and resection margin status indicated the presence of response migration. Conclusions: Despite increased pathologic tumor regression at the time of surgery, we observed no benefit on late outcome. Improved tumor regression does not necessarily lead to a relevant clinical benefit when the neoadjuvant treatment is followed by high-quality surgery.

  18. Preliminary results from an advanced lighting controlstestbed

    Energy Technology Data Exchange (ETDEWEB)

    Avery, Douglas; Jennings, Judity; Rubinstein, Francis

    1998-03-01

    Preliminary results from a large-scale testbed of advanced lighting control technologies at the Phillip Burton Federal Building at 450 Golden Gate Ave. in San Francisco are presented. The first year objective of this project is to determine the sustainable energy savings and cost-effectiveness of different lighting control technologies compared to a portion of the building where only minimal controls are installed. The paper presents the analyzed results from six months of tests focused on accurately characterizing the energy savings potential of one type of daylight-linked lighting controls compared to the lighting in similar open-planned areas without dimming controls. After analyzing a half year;s data, we determined that the annual energy savings for this type of daylight- linked controls was 41% and 30% for the outer rows of lights on the South and North sides of the building, respectively. The annual energy savings dropped to 22% and 16% for the second row of lights for the South and North, respectively, and was negligible for the third rows of lights.

  19. Modeling Malaysia's Energy System: Some Preliminary Results

    Directory of Open Access Journals (Sweden)

    Ahmad M. Yusof

    2011-01-01

    Full Text Available Problem statement: The current dynamic and fragile world energy environment necessitates the development of new energy model that solely caters to analyze Malaysia’s energy scenarios. Approach: The model is a network flow model that traces the flow of energy carriers from its sources (import and mining through some conversion and transformation processes for the production of energy products to final destinations (energy demand sectors. The integration to the economic sectors is done exogeneously by specifying the annual sectoral energy demand levels. The model in turn optimizes the energy variables for a specified objective function to meet those demands. Results: By minimizing the inter temporal petroleum product imports for the crude oil system the annual extraction level of Tapis blend is projected at 579600 barrels per day. The aggregate demand for petroleum products is projected to grow at 2.1% year-1 while motor gasoline and diesel constitute 42 and 38% of the petroleum products demands mix respectively over the 5 year planning period. Petroleum products import is expected to grow at 6.0% year-1. Conclusion: The preliminary results indicate that the model performs as expected. Thus other types of energy carriers such as natural gas, coal and biomass will be added to the energy system for the overall development of Malaysia energy model.

  20. Results of the European research project 'Improving the effectiveness of cancer treatment with 3D Brachytherapy'

    International Nuclear Information System (INIS)

    The project iMERA + T2.J06 'Improving the effectiveness of cancer treatment using 3D brachytherapy' was solved in the period 2008-2011 in collaboration of metrology institutes from 10 European Union countries, including participation of the Czech Republic. Its main objective was to create a means to ensure metrological quantity absorbed dose in water from brachyterapeutical (BT) sources enabling more accurate assessment of therapeutic benefit than using existing dosimetry protocols that are based on the quantity kerma in the air. This project is discussed.

  1. Viking first encounter of phobos: preliminary results.

    Science.gov (United States)

    Tolson, R H; Duxbury, T C; Born, G H; Christensen, E J; Diehl, R E; Farless, D; Hildebrand, C E; Mitchell, R T; Molko, P M; Morabito, L A; Palluconi, F D; Reichert, R J; Taraji, H; Veverka, J; Neugebauer, G; Findlay, J T

    1978-01-01

    During the last 2 weeks of February 1977, an intensive scientific investigation of the martian satellite Phobos was conducted by the Viking Orbiter-1 (VO-1) spacecraft. More than 125 television pictures were obtained during this period and infrared observations were made. About 80 percent of the illuminated hemisphere was imaged at a resolution of about 30 meters. Higher resolution images of limited areas were also obtained. Flyby distances within 80 kilometers of the surface were achieved. An estimate of the mass of Phobos (GM) was obtained by observing the effect of Phobos's gravity on the orbit of VO-1 as sensed by Earth-based radiometric tracking. Preliminary results indicate a value of GM of 0.00066 +/- 0.00012 cubic kilometer per second squared (standard deviation of 3) and a mean density of about 1.9 +/- 0.6 gram per cubic centimeter (standard deviation of 3). This low density, together with the low albedo and the recently determined spectral reflectance, suggest that Phobos is compositionally similar to type I carbonaceous chondrites. Thus, either this object formed in the outer part of the asteroid belt or Lewis's theory that such material cannot condense at 1.5 astronomical units is incorrect. The data on Phobos obtained during this first encounter period are comparable in quantity to all of the data on Mars returned by Mariner flights 4, 6, and 7. PMID:17841954

  2. Outcomes Following Iodine-125 Monotherapy for Localized Prostate Cancer: The Results of Leeds 10-Year Single-Center Brachytherapy Experience

    International Nuclear Information System (INIS)

    Purpose: This study reports the 10-year experience of permanent brachytherapy monotherapy at a single UK center. Methods and Materials: Between March 1995 and September 2004, 1,298 patients underwent trans-rectal ultrasound (TRUS) planned transperineal brachytherapy delivering 145 Gy using I-125. No patient received supplemental external beam; 44.2% received neoadjuvant hormones. In 688, CT postimplant dosimetry was available. Outcome data were analyzed in terms of overall survival (OS), disease specific survival (DSS), and PSA relapse-free survival (PSA-RFS). Results: The mean age was 62.9 (range, 34-83) years. Median follow-up was 4.9 years (range, 2.03-11.7 years). OS and DSS were 85% and 95%, respectively, at 10 years. Twenty-one patients died from prostate cancer (1.6%) and 34 (2.5%) from unrelated causes. Seventy-four (5.7%) developed evidence of clinical failure. Overall PSA-RFS was 79.9% and 72.1% at 10 years (American Society for Therapeutic Radiology and Oncology [ASTRO] and Nadir+2 definitions, respectively). Higher presenting PSA or Gleason score and use of neoadjuvant hormones were associated with an increased risk of biochemical failure (p 90 ≥140 Gy and in 78% of patients with D90 90 with biochemical control.

  3. Endovascular repair of aortic aneurysm: Preliminary results

    Directory of Open Access Journals (Sweden)

    Davidović Lazar

    2009-01-01

    Full Text Available Introduction. Endovascular aneurysm repair (EVAR has been introduced into clinical practice at the beginning of the 90's of the last century. Because of economic, political and social problems during the last 25 years, the introduction of this procedure in Serbia was not possible. Objective. The aim of this study was to present preliminary experiences and results of the Clinic for Vascular Surgery of the Serbian Clinical Centre in Belgrade in endovascular treatment of thoracic and abdominal aortic aneurysms. Methods. The procedure was performed in 33 patients (3 female and 30 male, aged from 42 to 83 years. Ten patients had a descending thoracic aorta aneurysm (three atherosclerotic, four traumatic - three chronic and one acute as a part of polytrauma, one dissected, two penetrated atherosclerotic ulcers, while 23 patients had the abdominal aortic aneurysm, one ruptured and two isolated iliac artery aneurysms. The indications for EVAR were isthmic aneurismal localisation, aged over 80 years and associated comorbidity (cardiac, pulmonary and cerebrovasular diseases, previous thoracotomy or multiple laparotomies associated with abdominal infection, idiopatic thrombocitopaenia. All of these patients had three or more risk factors. The diagnosis was established using duplex ultrasonography, angiography and MSCT. In the case of thoracic aneurysm, a Medtronic-Valiant® endovascular stent graft was implanted, while for the abdominal aortic aneurysm Medtronic-Talent® endovascular stent grafts with delivery systems were used. In three patients, following EVAR a surgical repair of the femoral artery aneurysm was performed, and in another three patients femoro-femoral cross over bypass followed implantation of aortouniiliac stent graft. Results. During procedure and follow-up period (mean 1.6 years, there were: one death, one conversion, one endoleak type 1, six patients with endoleak type 2 that disappeared during the follow-up period, one early graft

  4. Methodology, results and experience of independent brachytherapy plan verifications based on DICOM standard

    International Nuclear Information System (INIS)

    The use of a high dose rate source together with an afterloading treatment delivery in brachytherapy plans allows for dose modulation minimizing dose to staff. An independent verification of the exported data to the treatment station is required by local regulations (being also a widely accepted recommendation on the international literature2). We have developed a methodology under home brew code to import DICOM treatment data onto an Excel spreadsheet that is able to calculate dose on given reference points using the TG-43 formalism of the AAPM3-5. It employs analytic fits of anisotropy factor and radial dose function for different sources6-8. The end point implementations we present here allow merging in one step an independent verification and a treatment printout. The use of DICOM standard makes our code versatile and provides greater compatibility with respect to current treatment planning systems. (Author)

  5. High-Dose-Rate Brachytherapy as Monotherapy Delivered in Two Fractions Within One Day for Favorable/Intermediate-Risk Prostate Cancer: Preliminary Toxicity Data

    Energy Technology Data Exchange (ETDEWEB)

    Ghilezan, Michel, E-mail: mghilezan@beaumont.edu [Department of Radiation Oncology, William Beaumont Hospital and Rose Cancer Institute, Royal Oak, Michigan (United States); Martinez, Alvaro; Gustason, Gary; Krauss, Daniel; Antonucci, J. Vito; Chen, Peter; Fontanesi, James; Wallace, Michelle; Ye Hong; Casey, Alyse; Sebastian, Evelyn; Kim, Leonard; Limbacher, Amy [Department of Radiation Oncology, William Beaumont Hospital and Rose Cancer Institute, Royal Oak, Michigan (United States)

    2012-07-01

    Purpose: To report the toxicity profile of high-dose-rate (HDR)-brachytherapy (BT) as monotherapy in a Human Investigation Committee-approved study consisting of a single implant and two fractions (12 Gy Multiplication-Sign 2) for a total dose of 24 Gy, delivered within 1 day. The dose was subsequently increased to 27 Gy (13.5 Gy Multiplication-Sign 2) delivered in 1 day. We report the acute and early chronic genitourinary and gastrointestinal toxicity. Methods and Materials: A total of 173 patients were treated between December 2005 and July 2010. However, only the first 100 were part of the IRB-approved study and out of these, only 94 had a minimal follow-up of 6 months, representing the study population for this preliminary report. All patients had clinical Stage T2b or less (American Joint Committee on Cancer, 5th edition), Gleason score 6-7 (3+4), and prostate-specific antigen level of {<=}12 ng/mL. Ultrasound-guided HDR-BT with real-time dosimetry was used. The prescription dose was 24 Gy for the first 50 patients and 27 Gy thereafter. The dosimetric goals and constraints were the same for the two dose groups. Toxicity was scored using the National Cancer Institute Common Terminology Criteria for Adverse Events, version 3. The highest toxicity scores encountered at any point during follow-up are reported. Results: The median follow-up was 17 months (range, 6-40.5). Most patients had Grade 0-1 acute toxicity. The Grade 2 acute genitourinary toxicity was mainly frequency/urgency (13%), dysuria (5%), hematuria, and dribbling/hesitancy (2%). None of the patients required a Foley catheter at any time; however, 8% of the patients experienced transient Grade 1 diarrhea. No other acute gastrointestinal toxicities were found. The most common chronic toxicity was Grade 2 urinary frequency/urgency in 16% of patients followed by dysuria in 4% of patients; 2 patients had Grade 2 rectal bleeding and 1 had Grade 4, requiring laser treatment. Conclusions: Favorable

  6. High-Dose-Rate Brachytherapy as Monotherapy Delivered in Two Fractions Within One Day for Favorable/Intermediate-Risk Prostate Cancer: Preliminary Toxicity Data

    International Nuclear Information System (INIS)

    Purpose: To report the toxicity profile of high-dose-rate (HDR)-brachytherapy (BT) as monotherapy in a Human Investigation Committee-approved study consisting of a single implant and two fractions (12 Gy × 2) for a total dose of 24 Gy, delivered within 1 day. The dose was subsequently increased to 27 Gy (13.5 Gy × 2) delivered in 1 day. We report the acute and early chronic genitourinary and gastrointestinal toxicity. Methods and Materials: A total of 173 patients were treated between December 2005 and July 2010. However, only the first 100 were part of the IRB-approved study and out of these, only 94 had a minimal follow-up of 6 months, representing the study population for this preliminary report. All patients had clinical Stage T2b or less (American Joint Committee on Cancer, 5th edition), Gleason score 6-7 (3+4), and prostate-specific antigen level of ≤12 ng/mL. Ultrasound-guided HDR-BT with real-time dosimetry was used. The prescription dose was 24 Gy for the first 50 patients and 27 Gy thereafter. The dosimetric goals and constraints were the same for the two dose groups. Toxicity was scored using the National Cancer Institute Common Terminology Criteria for Adverse Events, version 3. The highest toxicity scores encountered at any point during follow-up are reported. Results: The median follow-up was 17 months (range, 6–40.5). Most patients had Grade 0-1 acute toxicity. The Grade 2 acute genitourinary toxicity was mainly frequency/urgency (13%), dysuria (5%), hematuria, and dribbling/hesitancy (2%). None of the patients required a Foley catheter at any time; however, 8% of the patients experienced transient Grade 1 diarrhea. No other acute gastrointestinal toxicities were found. The most common chronic toxicity was Grade 2 urinary frequency/urgency in 16% of patients followed by dysuria in 4% of patients; 2 patients had Grade 2 rectal bleeding and 1 had Grade 4, requiring laser treatment. Conclusions: Favorable-risk prostate cancer patients treated with

  7. Evolution of different reaction methods resulting in the formation of AgI125 for use in brachytherapy sources

    International Nuclear Information System (INIS)

    Prostate cancer represents about 10% of all cases of cancer in the world. Brachytherapy has been extensively used in the early and intermediate stages of the illness. The radiotherapy method reduces the damage probability to surrounding healthy tissues. The present study compares several deposition methods of iodine-125 on silver substrate (seed core), in order to choose the most suitable one to be implemented at IPEN. Four methods were selected: method 1 (assay based on electrodeposition) which presented efficiency of 65.16%; method 2 (assay based on chemical reactions, developed by David Kubiatowicz) which presented efficiency of 70.80%; method 3 (chemical reaction based on the methodology developed by Dr. Maria Elisa Rostelato) which presented efficiency of 55.80%; new method developed by IPEN with 90.5% efficiency. Based on the results, the new method is the suggested one to be implemented. (authors)

  8. Brachytherapy for carcinoma of the floor of mouth. Clinical results and considerations

    International Nuclear Information System (INIS)

    Forty-six patients with T1 and T2 carcinomas of the floor of mouth (FOM), who underwent brachytherapy from February 1979 to March 1991, were reviewed retrospectively. Four of the 46 patients died within 2 years of their initial treatment, without a local recurrence and/or radiation injury. Therefore, they were excluded from the evaluation of two-year local control and radiation injury rate. The two-year local control rate of the remaining 42 patients was 93% (39/42). The rate was 100% (27/27) in patients treated by brachytherapy (BT) alone, and 80% (12/15) in those treated by BT with external radiation (ERT) and chemotherapy. This rate was not elevated from that achieved at a dose of 70 Gy by BT (88%) when a dose of 80 Gy was given by BT with ERT (90%) in the dose-response relationship. According to tumor extension, the local control rates for pelvic-gingival (PG), pelvic (P) and pelvic-lingual (PL) tumors were 75% (6/8), 100% (19/19) and 93% (14/15), respectively. The two-year radiation injury (mandibular exposure) rate was 10% (4/42). The rate was 7% (2/27) in patients treated by BT alone and 13% (2/15) in those treated by BT with ERT, and was greatly elevated from that occurring with a dose of 70 Gy by BT (5%) when a dose of 80 Gy was given by BT with ERT (13%) in the dose-response relationship. According to tumor extention, the radiation injury rates for PG, P and PL tumors were 13% (1/8), 5% (1/19) and 13% (2/15), respectively. In conclusion, BT with ERT did not improve the local control rate of T1 and T2 carcinomas of FOM, and elevated the radiation injury rate greatly. Therefore, we believe that T1 and T2 carcinoma, even when extending to the gingiva, should be treated by BT alone. Multiple cancer incidence in these patients was 28% (13/46), and the incidence of digestive tract cancer was especially high. Therefore, a complete work-up is necessary before treatment and during the follow-up period. (author)

  9. Treatment results of stereotactic interstitial brachytherapy for primary and metastatic brain tumors

    Energy Technology Data Exchange (ETDEWEB)

    Lucas, G.L.; Luxton, G.; Cohen, D.; Petrovich, Z.; Langholz, B.; Apuzzo, M.L.; Sapozink, M.D. (USC School of Medicine, Los Angeles, CA (USA))

    1991-08-01

    A total of 41 stereotactic interstitial brain implants in 39 patients were performed for recurrence after teletherapy (recurrence implant), or as part of initial treatment in conjunction with teletherapy (primary implant). Implanted tumors consisted of malignant gliomas (33), other primary brain tumors (3), and single metastatic lesions (3). All patients were temporarily implanted with Ir-192 using a coaxial catheter afterloading system; two patients were implanted twice. Survival post-implant for glioblastoma multiforme (GBM), 13 patients, was 10 months whether implanted primarily or for recurrence. Mean time to recurrence, measured from initiation of teletherapy to implantation, was 10 months. Twenty patients with anaplastic astrocytoma (AA) had a median survival post-implant of 23 months for primary implants (7 patients) and 11 months for recurrence implants (13 patients). Mean time to recurrence, measured from initiation of teletherapy to implantation, was 19 months. Three patients (9%) of the evaluable group required reoperation for symptomatic mass effect, all with initial diagnosis of AA. Survival for this subgroup was 14, 22, and 32 months post-implantation. Using stereotactic techniques, interstitial brachytherapy of brain tumors was technically feasible with negligible acute morbidity and mortality, and appeared to offer limited prolongation of control for a subset of patients with recurrent malignant gliomas. The role of this modality in primary treatment for malignant gliomas needs to be further defined by prospectively randomized trials.

  10. Results of brachytherapy for cancer of the tongue with special emphasis on local prognosis

    Energy Technology Data Exchange (ETDEWEB)

    Horiuchi, J.; Okuyama, T.; Shibuya, H.; Takeda, M.

    1982-05-01

    One hundred and sixty-six patients with squamous cell carcinoma of the tongue were treated with radiation. Treatment modalities were mainly interstitial implant with or without external beam irradiation, except for early lesions, which were treated with intraoral electron beam therapy. Analysis was made on the local prognosis of the lesion to clarify the indications for interstitial therapy, especially the combined program with external beam therapy, and the time-dose relationship of the brachytherapy. Local recurrence-free rates (two years) were 94% in T1, 77% in T2 and 32% in T3 lesions, respectively. For T1 and surperficial or exophytic T2 lesions, the local recurrence-free rate was excellent with the interstitial therapy alone using either permanent implants of gold grain or radium implants. Therefore, prior external beam therapy seemed to be unnecessary for these lesions. When the treated area was less than 10 cm/sup 2/, subsequent complications were not likely even if the TDF (time-dose factor) value was high. Most of the patients who received combined external beam and interstitial therapy showed infiltrative T2 and a majority of the T3 lesions. In these patients, it was apparent that most of the total dose should be given from the interstitial implant after a small prior dose with external irradiation, because these lesions could not be cured even if the external dose was increased.

  11. Prostate brachytherapy

    Science.gov (United States)

    Implant therapy - prostate cancer; Radioactive seed placement; Internal radiation therapy - prostate; High dose radiation (HDR) ... Brachytherapy takes 30 minutes or more, depending on the type of therapy you have. Before the procedure, ...

  12. Topology and phase transitions I. Preliminary results

    International Nuclear Information System (INIS)

    In this first paper, we demonstrate a theorem that establishes a first step toward proving a necessary topological condition for the occurrence of first- or second-order phase transitions: we prove that the topology of certain submanifolds of configuration space must necessarily change at the phase transition point. The theorem applies to smooth, finite-range and confining potentials V bounded below, describing systems confined in finite regions of space with continuously varying coordinates. The relevant configuration space submanifolds are both the level sets {Σv:=VN-1(v)}velementofR of the potential function VN and the configuration space submanifolds enclosed by the Σv defined by {Mv:=VN-1((-∞,v])}velementofR, which are labeled by the potential energy value v, and where N is the number of degrees of freedom. The proof of the theorem proceeds by showing that, under the assumption of diffeomorphicity of the equipotential hypersurfaces {Σv}velementofR, as well as of the {Mv}velementofR, in an arbitrary interval of values for v-bar =v/N, the Helmholtz free energy is uniformly convergent in N to its thermodynamic limit, at least within the class of twice differentiable functions, in the corresponding interval of temperature. This preliminary theorem is essential to prove another theorem-in (paper II)-which makes a stronger statement about the relevance of topology for phase transitions

  13. Preliminary results of impeller design modifications

    International Nuclear Information System (INIS)

    Power consumption in the oil mixing process is very much affected by the impeller design. Minor modification on the impeller design might result in better mixing and less energy consumption. This paper reports an early stage of applying the observation technique to modify three standard impellers, namely the Pitched blade turbine impeller, the CHEMSHEAR impeller and the Vertical Flat-Blade Turbine Impeller. The advantages and disadvantages of these three impellers were analyzed; accordingly minor modification on the impeller design is adopted. The CFD tool is used to evaluate one of the modified impellers; results indicated that the modified impeller achieves better fluid dispersion.

  14. Danish Anaesthesia Allergy Centre - preliminary results

    DEFF Research Database (Denmark)

    Garvey, L H; Roed-Petersen, J; Menné, T;

    2001-01-01

    cases. Patients are tested with all substances they were exposed to, including antibiotics, colloids, latex and chlorhexidine. RESULTS: A total of 68 patients have been referred to date (July 2001) and 36 have completed investigations. Positive test results were mainly seen in patients with more severe...... reactions, and there were more men than women in the group with the most severe reactions. Six patients had positive specific IgE, three for penicillin, two for latex and one for thiopental. In all, 21 patients had positive skin tests to various substances, of whom four men with anaphylactic shock tested...

  15. Breast conserving therapy with sole high-dose-rate interstitial brachytherapy. Results of Osaka Medical Center for Cancer and Cardiovascular Diseases

    International Nuclear Information System (INIS)

    The results of breast conserving surgery combined with sole high-dose-rate interstitial brachytherapy were analyzed. Between May 1998 and May 2003, 20 patients with breast cancer smaller than 2 cm, without clinically lymph node metastases were recruited in our study. The 5-year local control rate, distant-free survival and overall survival were 92.9%, 92.9% and 92.9%, respectively. These results were the equal to those of breast conserving surgery with conventional whole breast 45-50 Gy irradiation in our institute. Though fat necrosis was occurred in one of 20 patients and radiation induced pneumonitis was also seen in one patient, the safety and cosmetic results of brachytherapy was acceptable. This technique can shorten the period of the breast conserving therapy and can become one of the treatment options of it. (author)

  16. Preliminary results of steel containment vessel model test

    Energy Technology Data Exchange (ETDEWEB)

    Luk, V.K.; Hessheimer, M.F. [Sandia National Labs., Albuquerque, NM (United States); Matsumoto, T.; Komine, K.; Arai, S. [Nuclear Power Engineering Corp., Tokyo (Japan); Costello, J.F. [Nuclear Regulatory Commission, Washington, DC (United States)

    1998-04-01

    A high pressure test of a mixed-scaled model (1:10 in geometry and 1:4 in shell thickness) of a steel containment vessel (SCV), representing an improved boiling water reactor (BWR) Mark II containment, was conducted on December 11--12, 1996 at Sandia National Laboratories. This paper describes the preliminary results of the high pressure test. In addition, the preliminary post-test measurement data and the preliminary comparison of test data with pretest analysis predictions are also presented.

  17. Viking magnetic properties investigation: preliminary results.

    Science.gov (United States)

    Hargraves, R B; Collinson, D W; Spitzer, C R

    1976-10-01

    Three permanent magnet arrays are aboard the Viking lander. By sol 35, one array, fixed on a photometric reference test chart on top of the lander, has clearly attracted magnetic particles from airborne dust; two other magnet arrays, one strong and one weak, incorporated in the backhoe of the surface sampler, have both extracted considerable magnetic mineral from the surface as a result of nine insertions associated with sample acquisition. The loose martian surface material around the landing site is judged to contain 3 to 7 percent highly magnetic mineral which, pending spectrophotometric study, is thought to be mainly magnetite. PMID:17793086

  18. Viking magnetic properties investigation - Preliminary results

    Science.gov (United States)

    Hargraves, R. B.; Collinson, D. W.; Spitzer, C. R.

    1976-01-01

    Three permanent-magnet arrays are aboard the Viking lander. By sol 35, one array, fixed on a photometric reference test chart on top of the lander, has clearly attracted magnetic particles from airborne dust; two other magnet arrays, one strong and one weak, incorporated in the backhoe of the surface sampler, have both extracted considerable magnetic mineral from the surface as a result of nine insertions associated with sample acquisition. The loose Martian surface material around the landing site is judged to contain 3 to 7 per cent highly magnetic mineral which, pending spectrophotometric study, is thought to be mainly magnetite.

  19. Medical Radioisotope Data Survey: 2002 Preliminary Results

    Energy Technology Data Exchange (ETDEWEB)

    Siciliano, Edward R.

    2004-06-23

    A limited, but accurate amount of detailed information about the radioactive isotopes used in the U.S. for medical procedures was collected from a local hospital and from a recent report on the U.S. Radiopharmaceutical Markets. These data included the total number of procedures, the specific types of procedures, the specific radioisotopes used in these procedures, and the dosage administered per procedure. The information from these sources was compiled, assessed, pruned, and then merged into a single, comprehensive and consistent set of results presented in this report. (PIET-43471-TM-197)

  20. Discovery program for bright quasars: preliminary results

    International Nuclear Information System (INIS)

    A program has been undertaken to obtain a complete sample of bright quasars on the basis of ultraviolet color excess. Spectroscopic examination of candidates selected from two-color Schmidt telescope films has yielded four new quasars brighter than B = 16/sup m/5, with the candidate list containing two more previously identified. Magnitudes, color indices, and redshifts are presented for the new discoveries, along with positions and finding charts. Although the sample is not yet complete, these first results suggest that bright quasars have a low surface density

  1. Salvage Brachytherapy for Biochemically Recurrent Prostate Cancer following Primary Brachytherapy

    Science.gov (United States)

    Lacy, John M.; Wilson, William A.; Bole, Raevti; Chen, Li; Meigooni, Ali S.; Rowland, Randall G.; Clair, William H. St.

    2016-01-01

    Purpose. In this study, we evaluated our experience with salvage brachytherapy after discovery of biochemical recurrence after a prior brachytherapy procedure. Methods and Materials. From 2001 through 2012 twenty-one patients treated by brachytherapy within University of Kentucky or from outside centers developed biochemical failure and had no evidence of metastases. Computed tomography (CT) scans were evaluated; patients who had an underseeded portion of their prostate were considered for reimplantation. Results. The majority of the patients in this study (61.9%) were low risk and median presalvage PSA was 3.49 (range 17.41–1.68). Mean follow-up was 61 months. At last follow-up after reseeding, 11/21 (52.4%) were free of biochemical recurrence. There was a trend towards decreased freedom from biochemical recurrence in low risk patients (p = 0.12). International Prostate Symptom Scores (IPSS) increased at 3-month follow-up visits but decreased and were equivalent to baseline scores at 18 months. Conclusions. Salvage brachytherapy after primary brachytherapy is possible; however, in our experience the side-effect profile after the second brachytherapy procedure was higher than after the first brachytherapy procedure. In this cohort of patients we demonstrate that approximately 50% oncologic control, low risk patients appear to have better outcomes than others. PMID:27092279

  2. Voice change after radiotherapy: some preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Colton, R.H.; Sagerman, R.H.; Chung, C.T.; Yu, Y.W.; Reed, G.F.

    1978-06-01

    A one-third octave spectral analysis was performed on two sentences spoken by 5 patients with laryngeal cancer, 5 with head/neck cancer not involving the vocal cords, and 12 normal subjects. Recordings were made prior to and at weekly intervals during radiotherapy as well as at periodic intervals post-treatment. Patients with laryngeal cancer exhibited lower spectral levels than normal throughout radiotherapy as well as several months post-treatment. By one year after treatment, the spectral levels of these patients were largely in the normal range. Patients with head/neck cancer not involving the vocal cords exhibited greater than normal sound pressure levels throughout most of the spectrum. These levels remained high even at one month post-treatment. Irradiation of normal vocal cord tissue also seems to result in higher spectral levels.

  3. Modelling Extortion Racket Systems: Preliminary Results

    Science.gov (United States)

    Nardin, Luis G.; Andrighetto, Giulia; Székely, Áron; Conte, Rosaria

    Mafias are highly powerful and deeply entrenched organised criminal groups that cause both economic and social damage. Overcoming, or at least limiting, their harmful effects is a societally beneficial objective, which renders its dynamics understanding an objective of both scientific and political interests. We propose an agent-based simulation model aimed at understanding how independent and combined effects of legal and social norm-based processes help to counter mafias. Our results show that legal processes are effective in directly countering mafias by reducing their activities and changing the behaviour of the rest of population, yet they are not able to change people's mind-set that renders the change fragile. When combined with social norm-based processes, however, people's mind-set shifts towards a culture of legality rendering the observed behaviour resilient to change.

  4. Preliminary results of a PACS implementation

    Science.gov (United States)

    Kishore, Sheel; Khalsa, Satjeet S.; Seshadri, Sridhar B.; Arenson, Ronald L.

    1991-07-01

    The Radiology Department at the University of Pennsylvania is in the process of clinically testing the first phase of its PACS implementation. The first phase has been designed to support two Intensive Care Units, two GE SIGNA MR units and a Du Pont FD 2000 Film Digitizer. The entire system has been running clinically for about three months. Any PACS effort involves integrating software and hardware from different manufactures. Some of the equipment on a PACS network are often 'closed' and provide limited access. In addition, the entire PACS system is expected to provide uninterrupted service, have adequate throughput and ensure data integrity. By and large, these goals have been met. Clinical testing has provided valuable insights about system integration and highlighted areas of improvement in the system design. A detailed discussion of these results is presented.

  5. Emetophobia: preliminary results of an internet survey.

    Science.gov (United States)

    Lipsitz, J D; Fyer, A J; Paterniti, A; Klein, D F

    2001-01-01

    Through electronic mail, we surveyed members of an internet support group for emetophobia (fear of vomiting). Respondents were 50 women and 6 men with a mean age of 31 years. Results suggest that, for this sample, emetophobia is a disorder of early onset and chronic course, with highly persistent and intrusive symptoms. Emetophobia is implicated in social, home-marital, and occupational impairment and it causes significant constriction of leisure activities. Nearly half of women avoided or delayed becoming pregnant. About three quarters of respondents have eating rituals or significantly limit the foods they eat. Respondents describe other problems such as depression, panic attacks, social anxiety, compulsions, and frequent history of childhood separation anxiety. PMID:11668669

  6. Voice change after radiotherapy: some preliminary results

    International Nuclear Information System (INIS)

    A one-third octave spectral analysis was performed on two sentences spoken by 5 patients with laryngeal cancer, 5 with head/neck cancer not involving the vocal cords, and 12 normal subjects. Recordings were made prior to and at weekly intervals during radiotherapy as well as at periodic intervals post-treatment. Patients with laryngeal cancer exhibited lower spectral levels than normal throughout radiotherapy as well as several months post-treatment. By one year after treatment, the spectral levels of these patients were largely in the normal range. Patients with head/neck cancer not involving the vocal cords exhibited greater than normal sound pressure levels throughout most of the spectrum. These levels remained high even at one month post-treatment. Irradiation of normal vocal cord tissue also seems to result in higher spectral levels

  7. Renal imaging at 7 Tesla: preliminary results

    International Nuclear Information System (INIS)

    To investigate the feasibility of 7T MR imaging of the kidneys utilising a custom-built 8-channel transmit/receive radiofrequency body coil. In vivo unenhanced MR was performed in 8 healthy volunteers on a 7T whole-body MR system. After B0 shimming the following sequences were obtained: 1) 2D and 3D spoiled gradient-echo sequences (FLASH, VIBE), 2) T1-weighted 2D in and opposed phase 3) True-FISP imaging and 4) a T2-weighted turbo spin echo (TSE) sequence. Visual evaluation of the overall image quality was performed by two radiologists. Renal MRI at 7T was feasible in all eight subjects. Best image quality was found using T1-weighted gradient echo MRI, providing high anatomical details and excellent conspicuity of the non-enhanced vasculature. With successful shimming, B1 signal voids could be effectively reduced and/or shifted out of the region of interest in most sequence types. However, T2-weighted TSE imaging remained challenging and strongly impaired because of signal heterogeneities in three volunteers. The results demonstrate the feasibility and diagnostic potential of dedicated 7T renal imaging. Further optimisation of imaging sequences and dedicated RF coil concepts are expected to improve the acquisition quality and ultimately provide high clinical diagnostic value. (orig.)

  8. Preliminary results of stevia plant (Stevia rebaudiana

    Directory of Open Access Journals (Sweden)

    NOC FASLLIA

    2014-06-01

    Full Text Available The study was conducted at the experimental plots of the Agricultural Technology Transfer Center(ATTC Fushe - Kruja, from 2013 to 2014. The objectives of this study were, recognition with bio morphology of the growth and development of Stevios plant under conditions of our country. The study design consists of 30 plant pots planted with the STEVIAS. Indicators studied, were: time of planting, the beginning of growth, plant growth height in cm, number of brothers, number of branches in the main branch, the average number of leaves, total number of leaves. Planting was carried out on 20 February 2013, followed by the onset of growth on 3/25/2013 to 3/04/2014, ripening and harvest in September 5-10 October. At the end of the production these results were taken according to the study indicators. The height of the plant was carried 71.53 ± 11.08cm, depending on feeding conditions and illumination which according to requirements of this plant is one of the most dominant factors. The average number of brothers per branch is to 10.6 ± 2.4, which shows a high potential for stevia plant production. The average number of leaves per branch is 48.13 ± 9.26, and with a total leaves of 517. 03 ± 176.25, which are quantitative harvestable indicators of plant. Weight of plant was conducted at 49.46 ± 4.987gr.

  9. 106Ruthenium Brachytherapy for Retinoblastoma

    International Nuclear Information System (INIS)

    Purpose: To evaluate the efficacy of 106Ru plaque brachytherapy for the treatment of retinoblastoma. Methods and Materials: We reviewed a retrospective, noncomparative case series of 39 children with retinoblastoma treated with 106Ru plaques at the Jules-Gonin Eye Hospital between October 1992 and July 2006, with 12 months of follow-up. Results: A total of 63 tumors were treated with 106Ru brachytherapy in 41 eyes. The median patient age was 27 months. 106Ru brachytherapy was the first-line treatment for 3 tumors (4.8%), second-line treatment for 13 (20.6%), and salvage treatment for 47 tumors (74.6%) resistant to other treatment modalities. Overall tumor control was achieved in 73% at 1 year. Tumor recurrence at 12 months was observed in 2 (12.5%) of 16 tumors for which 106Ru brachytherapy was used as the first- or second-line treatment and in 15 (31.9%) of 47 tumors for which 106Ru brachytherapy was used as salvage treatment. Eye retention was achieved in 76% of cases (31 of 41 eyes). Univariate and multivariate analyses revealed no statistically significant risk factors for tumor recurrence. Radiation complications included retinal detachment in 7 (17.1%), proliferative retinopathy in 1 (2.4%), and subcapsular cataract in 4 (9.7%) of 41 eyes. Conclusion: 106Ru brachytherapy is an effective treatment for retinoblastoma, with few secondary complications. Local vitreous seeding can be successfully treated with 106Ru brachytherapy

  10. Retrospective study of the local control and the cosmetic result of 147 face carcinomas after interstitial brachytherapy; Etude retrospective du controle local et du resultat cosmetique de 147 carcinomes de la face apres curietherapie interstitielle

    Energy Technology Data Exchange (ETDEWEB)

    Ducassou, A.; David, I.; Bonnet, J.; Delannes, M. [Institut Claudius-Regaud, Service de Radiotherapie, 31 - Toulouse (France)

    2009-10-15

    The purpose was to evaluate retrospectively the local control rate and the cosmetic results for patients that received an interstitial brachytherapy for a base or spino-cellular carcinoma of face orifices areas. The interstitial brachytherapy by iridium 192 is an excellent alternative to surgery in the skin carcinomas of the face, as well at the level of local control as the cosmetic and functional results. (N.C.)

  11. Accelerated Partial Breast Irradiation: 5-Year Results of the German-Austrian Multicenter Phase II Trial Using Interstitial Multicatheter Brachytherapy Alone After Breast-Conserving Surgery

    International Nuclear Information System (INIS)

    Purpose: To evaluate the impact of accelerated partial breast irradiation on local control, side effects, and cosmesis using multicatheter interstitial brachytherapy as the sole method for the adjuvant local treatment of patients with low-risk breast cancer. Methods and Materials: 274 patients with low-risk breast cancer were treated on protocol. Patients were eligible for the study if the tumor size was 35 years, hormone receptors were positive, and histologic grades were 1 or 2. Of the 274 patients, 175 (64%) received pulse-dose-rate brachytherapy (Dref = 50 Gy). and 99 (36%) received high-dose-rate brachytherapy (Dref = 32.0 Gy). Results: Median follow-up was 63 months (range, 9-103). Only 8 of 274 (2.9%) patients developed an ipsilateral in-breast tumor recurrence at the time of analysis. The 5-year actuarial local recurrence-free survival probability was 98%. The 5- year overall and disease-free survival probabilities of all patients were 97% and 96%, respectively. Contralateral in-breast malignancies were detected in 2 of 274 (0.7%) patients, and distant metastases occurred in 6 of 274 (2.2%). Late side effects ≥Grade 3 (i.e., breast tissue fibrosis and telangiectasia) occurred in 1 patient (0.4%, 95%CI:0.0-2.0%) and 6 patients (2.2%, 95%CI:0.8-4.7%), respectively. Cosmetic results were good to excellent in 245 of 274 patients (90%). Conclusions: The long-term results of this prospective Phase II trial confirm that the efficacy of accelerated partial breast irradiation using multicatheter brachytherapy is comparable with that of whole breast irradiation and that late side effects are negligible.

  12. Results of 226Ra brachytherapy for T1, T2 tongue carcinoma and the clinical implication of ploidy and potential doubling time as prognostic factors

    International Nuclear Information System (INIS)

    Results of 226Ra brachytherapy for 47 patients with T1 and T2 tongue carcinoma were estimated and the clinical implication of ploidy and potential doubling time (Tpot) was discussed. Dose estimation was performed by using the dose distribution obtained from computerized dose calculators, considering Paterson-Parker's system. For T2 carcinoma, external beam irradiation (20-50 Gy) was carried out in the 12 patients and intensive chemotherapy was combined in the 16 patients. Ipsilateral neck dissection was performed for 3 out of the 4 T2N1 patients. Ploidy was analysed with flow cytometer and Tpot was obtained from in vitro labeling with bromodeoxyuridine and immunohistochemical stain. A five-year cause specific survival was 92% for T1 and 91% for T2, respectively. A five-year tumor control probability was 86% for T1 and 88% for T2, respectively. Combined intensive chemotherapy and external beam irradiation showed poorer treatment results than those without the modalities. ''Down-staging'' with the preceding combined modalities before 226Ra brachytherapy possibly had a risk to cause a geographical miss of needle implant. The significant role of Tpot was unclear. Ploidy of the tumors showed some predictive potential for the therapeutic results and the frequency of occult neck node metastasis. Optimization of brachytherapy based on the computerized dose estimation and the clinical application of biological predictors of tumors including ploidy should be considered for the treatment of tongue carcinoma. (author)

  13. Local Control Following Permanent Prostate Brachytherapy: Effect of High Biologically Effective Dose on Biopsy Results and Oncologic Outcomes

    International Nuclear Information System (INIS)

    Purpose: To determine factors that influence local control and systemic relapse in patients undergoing permanent prostate brachytherapy (PPB). Methods and Materials: A total of 584 patients receiving PPB alone or PPB with external beam radiation therapy (19.5%) agreed to undergo prostate biopsy (PB) at 2 years postimplantion and yearly if results were positive or if the prostate-specific antigen (PSA) level increased. Short-term hormone therapy was used with 280 (47.9%) patients. Radiation doses were converted to biologically effective doses (BED) (using α/β = 2). Comparisons were made by chi-square analysis and linear regression. Survival was determined by the Kaplan-Meier method. Results: The median PSA concentration was 7.1 ng/ml, and the median follow-up period was 7.1 years. PB results were positive for 48/584 (8.2%) patients. Positive biopsy results by BED group were as follows: 22/121 (18.2%) patients received a BED of ≤150 Gy; 15/244 (6.1%) patients received >150 to 200 Gy; and 6/193 (3.1%; p 200 Gy. Significant associations of positive PB results by risk group were low-risk group BED (p = 0.019), intermediate-risk group hormone therapy (p = 0.011) and BED (p = 0.040), and high-risk group BED (p = 0.004). Biochemical freedom from failure rate at 7 years was 82.7%. Biochemical freedom from failure rate by PB result was 84.7% for negative results vs. 59.2% for positive results (p 200 Gy with an α/β ratio of 2 yields 96.9% local control rate. Failure to establish local control impacts survival.

  14. 5-Year results of pulsed dose rate brachytherapy applied as a boost after breast-conserving therapy in patients at high risk for local recurrence from breast cancer

    International Nuclear Information System (INIS)

    Purpose: The aim of this study was to evaluate effect, toxicity, and cosmesis of a prospectively applied pulsed dose rate (PDR) brachytherapy boost schedule in patients with stage I/II/IIIa invasive breast cancer. Patients and Methods: A total of 113 patients were treated after breast-conserving surgery (BCS) and external beam radiotherapy (median 50 Gy, range 46-52). The boost dose was graded in accordance to the pathologic tumor characteristics: 20-25 Gy: incomplete resection (n=34), vascular invasion (n=27), close margin resection (n=41); 15 Gy: T2G3 stage (n=11). PDR brachytherapy (37 GBq, 192Ir source) was carried out after geometric volume optimization with 1 Gy/pulse/h. The implantation and dose specification were performed similar to the rules of the Paris system. Results: The overall local failure rate after a median follow-up of 61 months was 4.4% (5/113). The actuarial 5- and 8-year local recurrence-free survival rates were 95% and 93%, respectively. Cosmesis was rate by 90% of the patients as excellent or good. 14/113 patients experienced grade III (all caused by planar telangiectasia) and none of the patients grade IV late toxicity of the skin (RTOG/EORTC). A boost dose of 25 Gy resulted in a significantly higher rate of late toxicity (Fisher's exact test, p<0.01). Conclusions: PDR brachytherapy is safe, effective, and provides good cosmesis. A CLDR breast boost can be replaced by PDR brachytherapy without significant loss of therapeutic ratio. (orig.)

  15. Toxicity and cosmetic result of partial breast high-dose-rate interstitial brachytherapy for conservatively operated early breast cancer

    International Nuclear Information System (INIS)

    Objective: Objective To study the method, side effects and cosmetic outcome of high- dose-rate (HDR) accelerated partial breast interstitial irradiation (APBI) alone in early stage breast cancer' after conservative surgery. Methods: From February 2002 to June 2003,47 breast cancer lesions from 46 patients suffering from stage I/II breast cancer were treated with HDR 192Ir APBI after conservative surgery. All patients were over 40 year-old, with T1-2N0-1 (≤3 lymph nodes positive), surgical margin > 1-2 mm, but those having lobular or inflammatory breast cancer were excluded. HDR brachytherapy with 34 Gy, 10 fractions/5 days was used after surgery, toxic reaction and cosmetic outcome were observed in one month, 6 and 12 months respectively. Results: Follow up of 1846 months, 34 months was carried out for the whole group. During the treatment, acute reactions including: erythema, edema, tenderness and infection, all under I-II grade, none of III-IV grade were observed in 21 patients(46%); late toxicity reactions: skin fibrosis, breast tenderness, fat necrosis, and telangiectasia, totally 20 patients (43%) were observed: 2 patients in III grade but one patient received 6 cycle chemotherapy. The result of cosmetic outcome evaluation was excellent or good, at 6 months 95% and 12 months 98%, respectively, but there was no recurfence. Conclusions: Excellent and favorable cosmetic results are noted after APBI by interstitial alone. Acute and late reactions are few. Long term observation is necessary for the rate of' local control. (authors)

  16. Connecticut Transit (CTTRANSIT) Fuel Cell Transit Bus: Preliminary Evaluation Results

    Energy Technology Data Exchange (ETDEWEB)

    Chandler, K.; Eudy, L.

    2008-10-01

    This report provides preliminary results from a National Renewable Energy Laboratory evaluation of a protoptye fuel cell transit bus operating at Connecticut Transit in Hartford. Included are descriptions of the planned fuel cell bus demonstration and equipment; early results and agency experience are also provided.

  17. Metal rich stars in omega Cen: preliminary FLAMES GTO results

    CERN Document Server

    Pancino, E

    2004-01-01

    I present preliminary results for a sample of ~700 red giants in omega Cen, observed during the Ital-FLAMES Consortium GTO time in May 2003, for the Bologna Project on omega Cen. Preliminary Fe and Ca abundances confirm previous results: while the metal-poor and intermediate populations show a normal halo alpha-enhancement of [alpha/Fe]=$+0.3, the most metal-rich stars show a significantly lower [alpha/Fe]=+0.1. If the metal-rich stars have evolved within the cluster in a process of self-enrichment, the only way to lower their alpha-enhancement would be SNe type Ia intervention.

  18. High-Dose-Rate Interstitial Brachytherapy as Monotherapy for Clinically Localized Prostate Cancer: Treatment Evolution and Mature Results

    International Nuclear Information System (INIS)

    Purpose: To report the clinical outcome of high-dose-rate (HDR) interstitial (IRT) brachytherapy (BRT) as sole treatment (monotherapy) for clinically localized prostate cancer. Methods and Materials: Between January 2002 and December 2009, 718 consecutive patients with clinically localized prostate cancer were treated with transrectal ultrasound (TRUS)-guided HDR monotherapy. Three treatment protocols were applied; 141 patients received 38.0 Gy using one implant in 4 fractions of 9.5 Gy with computed tomography-based treatment planning; 351 patients received 38.0 Gy in 4 fractions of 9.5 Gy, using 2 implants (2 weeks apart) and intraoperative TRUS real-time treatment planning; and 226 patients received 34.5 Gy, using 3 single-fraction implants of 11.5 Gy (3 weeks apart) and intraoperative TRUS real-time treatment planning. Biochemical failure was defined according to the Phoenix consensus, and toxicity was evaluated using Common Toxicity Criteria for Adverse Events version 3. Results: The median follow-up time was 52.8 months. The 36-, 60-, and 96-month biochemical control and metastasis-free survival rates for the entire cohort were 97%, 94%, and 90% and 99%, 98%, and 97%, respectively. Toxicity was scored per event, with 5.4% acute grade 3 genitourinary and 0.2% acute grade 3 gastrointestinal toxicity. Late grade 3 genitourinary and gastrointestinal toxicities were 3.5% and 1.6%, respectively. Two patients developed grade 4 incontinence. No other instance of grade 4 or greater acute or late toxicity was reported. Conclusion: Our results confirm IRT-HDR-BRT is safe and effective as monotherapy for clinically localized prostate cancer

  19. Long-Term Results of Brachytherapy for Carcinoma of the Penis Confined to the Glans (N- or NX)

    International Nuclear Information System (INIS)

    Purpose: To analyze the results of exclusive interstitial low-dose-rate brachytherapy (BT) for squamous cell carcinoma (SCC) of the penis, strictly confined to the glans. Methods and Materials: A total of 144 patients with SSC of the glans penis were treated with BT. Inguinal nodal dissection was performed in 19% of patients (all N-). After circumcision, BT was performed using the hypodermic needle technique. Median iridium length per patients was 24 cm (range, 4-108) and median dose was 65 Gy (range, 37-75). Median treated volume was 22 cm3 (range, 5-110) and median reference isodose rate was 0.4 Gy/h (range, 0.2-1.2). Results: Median follow-up was 5.7 years (range, 0.5-29). The 10-year penile recurrence, inguinal lymph node recurrence, and inguinal nodal metastasis rates were: 20% (CI 95%, 11-29), 11% (CI 95%, 5-17), and 6% (CI 95%, 2-10), respectively. After salvage treatment, 86% patients with local failure were in a complete remission at last follow-up. The 10-year probability of avoiding penile surgery (for complication or local recurrence) was 72% (CI 95%, 62-82). The 10-year cancer-specific survival rate was 92% (CI 95%, 87-97). Diameter of tumor significantly increased the risk of recurrence (p = 0.02). The 10-year painful ulceration and stenosis risk rates were: 26% (CI 95%, 17-35) and 29% (CI 95%, 18-40), respectively. Seven patients required excision for necrosis. Treated volume and reference isodose rate significantly increased the risk of complications. Conclusion: BT is an effective conservative treatment for SCC confined to the glans. Salvage local treatment is effective. Dose rate should be limited to decrease toxicity.

  20. Bladder Function Preservation With Brachytherapy, External Beam Radiation Therapy, and Limited Surger in Bladder Cancer Patients: Long-Term Results

    International Nuclear Information System (INIS)

    Purpose: To report long-term results of a bladder preservation strategy for muscle-invasive bladder cancer (MIBC) using external beam radiation therapy and brachytherapy/interstitial radiation therapy (IRT). Methods and Materials: Between May 1989 and October 2011, 192 selected patients with MIBC were treated with a combined regimen of preoperative external beam radiation therapy and subsequent surgical exploration with or without partial cystectomy and insertion of source carrier tubes for afterloading IRT using low dose rate and pulsed dose rate. Data for oncologic and functional outcomes were prospectively collected. The primary endpoints were local recurrence-free survival (LRFS), bladder function preservation survival, and salvage cystectomy-free survival. The endpoints were constructed according to the Kaplan-Meier method. Results: The mean follow-up period was 105.5 months. The LRFS rate was 80% and 73% at 5 and 10 years, respectively. Salvage cystectomy-free survival at 5 and 10 years was 93% and 85%. The 5- and 10-year overall survival rates were 65% and 46%, whereas cancer-specific survival at 5 and 10 years was 75% and 67%. The distant metastases-free survival rate was 76% and 69% at 5 and 10 years. Multivariate analysis revealed no independent predictors of LRFS. Radiation Therapy Oncology Group grade ≥3 late bladder and rectum toxicity were recorded in 11 patients (5.7%) and 2 patients (1%), respectively. Conclusions: A multimodality bladder-sparing regimen using IRT offers excellent long-term oncologic outcome in selected patients with MIBC. The late toxicity rate is low, and the majority of patients preserve their functional bladder

  1. Protocol-based image-guided salvage brachytherapy. Early results in patients with local failure of prostate cancer after radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Lahmer, G.; Lotter, M.; Kreppner, S.; Fietkau, R.; Strnad, V. [University Hospital Erlangen (Germany). Dept. of Radiation Oncology

    2013-08-15

    Purpose: To assess the overall clinical outcome of protocol-based image-guided salvage pulsed-dose-rate brachytherapy for locally recurrent prostate cancer after radiotherapy failure particularly regarding feasibility and side effects. Patients and methods: Eighteen consecutive patients with locally recurrent prostate cancer (median age, 69 years) were treated during 2005-2011 with interstitial PDR brachytherapy (PDR-BT) as salvage brachytherapy after radiotherapy failure. The treatment schedule was PDR-BT two times with 30 Gy (pulse dose 0.6 Gy/h, 24 h per day) corresponding to a total dose of 60 Gy. Dose volume adaptation was performed with the aim of optimal coverage of the whole prostate (V{sub 100} > 95 %) simultaneously respecting the protocol-based dose volume constraints for the urethra (D{sub 0.1} {sub cc} < 130 %) and the rectum (D{sub 2} {sub cc} < 50-60 %) taking into account the previous radiation therapy. Local relapse after radiotherapy (external beam irradiation, brachytherapy with J-125 seeds or combination) was confirmed mostly via choline-PET and increased PSA levels. The primary endpoint was treatment-related late toxicities - particularly proctitis, anal incontinence, cystitis, urinary incontinence, urinary frequency/urgency, and urinary retention according to the Common Toxicity Criteria. The secondary endpoint was PSA-recurrence-free survival. Results: We registered urinary toxicities only. Grade 2 and grade 3 toxicities were observed in up to 11.1 % (2/18) and 16.7 % (3/18) of patients, respectively. The most frequent late-event grade 3 toxicity was urinary retention in 17 % (3/18) of patients. No late gastrointestinal side effects occurred. The biochemical PSA-recurrence-free survival probability at 3 years was 57.1 %. The overall survival at 3 years was 88.9 %; 22 % (4/18) of patients developed metastases. The median follow-up time for all patients after salvage BT was 21 months (range, 8-77 months). Conclusion: Salvage PDR-brachytherapy

  2. Clinical experience with the MammoSite[reg] radiation therapy system for brachytherapy of breast cancer: Results from an international phase II trial

    International Nuclear Information System (INIS)

    Background and purpose: In a prospective multi-center phase II trial, we investigated the MammoSite[reg] Radiation Therapy System, a new device for delivering intracavitary brachytherapy following breast conserving surgery. The MammoSite[reg] is a dual lumen, closed ended catheter with a small, spherical inflatable balloon and a port for connecting a remote afterloader to the central lumen. We analyzed the surgical procedure and placement of the MammoSite[reg], treatment planning and radiation delivery complications and cosmesis, as well the comfort for the patients. Patients and methods: Between 2002 and 2004 a total of 32 patients (pts) were implanted using the MammoSite[reg]. The reference isodose was defined 1 cm from the balloon surface. We analyzed the post-implant anatomic position of the applicator and the geometric form of the balloon via ultrasound, CT and X-ray, related side effects, cosmetic outcome and patient quality of life. Results: Twenty-three out of 32 patients (72%) were eligible for MammoSite[reg] intracavitary brachytherapy. Twenty-eight percentage had to be excluded because of different reasons. Eleven patients were treated with primary brachytherapy with a total dose of 34 Gy (2x3.4 Gy) and 12 had a boost with a mean dose of 13.3 Gy (range: 7.5-15 Gy; 2x2.5 Gy) combined with EBRT and doses ranged between 46 and 50 Gy. In three cases a balloon rupture occurred. We observed two abscesses within 3 months of implantation and serious seroma development in 10 patients (39%). Skin related side effects were erythema in 21 patients (91%), hyperpigmentation in 13 patients (56%) and teleangiectasia in six patients (26%) after mean follow-up 20 months. Conclusions: The MammoSite[reg] Radiation Therapy System is a feasible treatment modality for intracavitary brachytherapy of breast cancer after breast conserving surgery. The advantage of the system is only one applicator is necessary for the delivery of a fractionated radiotherapy. In addition, patient

  3. Brachytherapy versus prostatectomy in localized prostate cancer: Results of a French multicenter prospective medico-economic study

    International Nuclear Information System (INIS)

    Purpose: To prospectively compare health-related quality of life (HRQOL), patient-reported treatment-related symptoms, and costs of iodine-125 permanent implant interstitial brachytherapy (IB) with those of radical prostatectomy (RP) during the first 2 years after these treatments for localized prostate cancer. Methods and Materials: A total of 435 men with localized low-risk prostate cancer, from 11 French hospitals, treated with IB (308) or RP (127), were offered to complete the European Organization for Research and Treatment of Cancer core Quality of Life Questionnaire QLQ-C30 version 3 (EORTC QLQ-C30) and the prostate cancer specific EORTC QLQ-PR25 module before and at the end of treatment, 2, 6, 12, 18, and 24 months after treatment. Repeated measures analysis of variance and analysis of covariance were conducted on HRQOL changes. Comparative cost analysis covered initial treatment, hospital follow-up, outpatient and production loss costs. Results: Just after treatment, the decrease of global HRQOL was less pronounced in the IB than in the RP group, with a 13.5 points difference (p < 0.0001). A difference slightly in favor of RP was observed 6 months after treatment (-7.5 points, p = 0.0164) and was maintained at 24 months (-8.2 points, p = 0.0379). Impotence and urinary incontinence were more pronounced after RP, whereas urinary frequency, urgency, and urination pain were more frequent after IB. Mean societal costs did not differ between IB ( Euro 8,019 at T24) and RP ( Euro 8,715 at T24, p = 0.0843) regardless of the period. Conclusions: This study suggests a similar cost profile in France for IB and RP but with different HRQOL and side effect profiles. Those findings may be used to tailor localized prostate cancer treatments to suit individual patients' needs

  4. Permanent prostate brachytherapy: Dosimetric results and analysis of a learning curve with a dynamic dose-feedback technique

    International Nuclear Information System (INIS)

    Purpose: A permanent prostate brachytherapy (PPB) program utilizing intraoperative inverse-planned dynamic dose-feedback was initiated without prior firsthand experience of alternative techniques. The purpose of this study is to assess the dosimetric learning curve associated with this approach. Methods and Materials: A total of 77 patients underwent PPB implants as monotherapy for localized prostate cancer to a prescription dose of 145 Gy with loose 125I seeds between December 2003 and June 2004. Intraoperative and postoperative dosimetric values, total implanted radioactivity, and operating room (OR) times were compared by sequential case number for all cases. Results: The median intraoperative dosimetric values were: D90 (the minimum dose to 90% of the prostate) = 170 Gy (range, 135-203 Gy), V100 (the volume of the prostate that receives 100% of the prescription dose) = 96% (range, 86-100), V150 = 66% (range, 34-86). Median postoperative dosimetric values were as follows: D90 = 168 Gy (range, 132-197 Gy), V100 = 95% (range, 86-99), V150 = 74% (range, 51-84). Median implanted activity was 0.79 mCi per cubic centimeter of prostate (range, 0.541-1.13). There was no significant correlation by case number on any postoperative dosimetric parameter studied. Door-to-door OR time was reduced from median 138 to 97.5 min per case at the end of the series with a correlation coefficient of -0.76 for the initial 28 cases. Conclusion: Satisfactory dosimetric parameters can be achieved from the outset without a learning curve effect in an appropriately trained environment. The learning curve for dynamic dose-feedback PPB in a clinic naive to other techniques is apparent in terms of OR time

  5. Hydrogen-burn survival: preliminary thermal model and test results

    Energy Technology Data Exchange (ETDEWEB)

    McCulloch, W.H.; Ratzel, A.C.; Kempka, S.N.; Furgal, D.T.; Aragon, J.J.

    1982-08-01

    This report documents preliminary Hydrogen Burn Survival (HBS) Program experimental and analytical work conducted through February 1982. The effects of hydrogen deflagrations on safety-related equipment in nuclear power plant containment buildings are considered. Preliminary results from hydrogen deflagration experiments in the Sandia Variable Geometry Experimental System (VGES) are presented and analytical predictions for these tests are compared and discussed. Analytical estimates of component thermal responses to hydrogen deflagrations in the upper and lower compartments of an ice condenser, pressurized water reactor are also presented.

  6. Hydrogen-burn survival: preliminary thermal model and test results

    International Nuclear Information System (INIS)

    This report documents preliminary Hydrogen Burn Survival (HBS) Program experimental and analytical work conducted through February 1982. The effects of hydrogen deflagrations on safety-related equipment in nuclear power plant containment buildings are considered. Preliminary results from hydrogen deflagration experiments in the Sandia Variable Geometry Experimental System (VGES) are presented and analytical predictions for these tests are compared and discussed. Analytical estimates of component thermal responses to hydrogen deflagrations in the upper and lower compartments of an ice condenser, pressurized water reactor are also presented

  7. The 2dF Galaxy Redshift Survey: Preliminary Results

    OpenAIRE

    Maddox, S.

    1997-01-01

    Spectroscopic observations for a new survey of 250 000 galaxy redshifts are underway, using the 2dF instrument at the AAT. The input galaxy catalogue and commissioning data are described. The first result from the preliminary data is a new estimate of the galaxy luminosity function at =0.1.

  8. Preliminary results of neutron production in Sahand plasma focus device

    International Nuclear Information System (INIS)

    We report in this paper the preliminary results of neutron generation during fusion reaction in deuterium in the Sahand Filipov type plasma focus, recently installed and put in operation at Tabriz University. The special calibration procedure for neutron detection system, using activation method is described

  9. On the quadratic stability of switched interval systems: Preliminary results

    OpenAIRE

    Zeheb, Ezra; Mason, Oliver; SOLMAZ, Selim; Shorten, Robert

    2005-01-01

    In this paper we present some preliminary results on the quadratic stability of switched systems with uncertain parameters. We show that the quadratic stability of a class of switched uncertain systems may be readily verified using simple algebraic conditions. Examples are presented to demonstrate the efficacy of our techniques.

  10. Structural investigations of biogenic iron oxide samples. Preliminary results

    International Nuclear Information System (INIS)

    Some preliminary results on morphology and structure of iron oxide particles formed inside Klebsiella oxytoca bacteria are presented. In particular, by means of optical microscopy, scanning electron microscopy and small-angle X-ray scattering the effect of the bacteria age (the duration of growth) on the nanoparticles properties is studied

  11. Radon concentrations in Norwegian kindergartens: survey planning and preliminary results

    International Nuclear Information System (INIS)

    An extensive radon survey in Norwegian kindergartens and schools was started in early 1997; so far 2481 kindergartens were examined. Preliminary results of the first phase of the survey are presented in tabular and graphic form including, among others, the dependence of average radon concentration on the construction year of the kindergartens and on the age of the buildings. (A.K.)

  12. Preliminary results of the surveillance extension program of NPP Paks

    International Nuclear Information System (INIS)

    The paper describes the preliminary stage of the surveillance extension programme at NPP Paks. To prepare the surveillance extension programme 5 set of specimens including 6 different forging and weldment have been irradiated and tested. The obtained results are used in the final design of the extended surveillance programme of NPP Paks. (author). 3 refs, 6 figs, 1 tab

  13. The friction of polymers around Tg,Tm : Preliminary results

    DEFF Research Database (Denmark)

    Sivebæk, Ion Marius; Samoilov, V N; Persson, B N J

    We present Molecular Dynamics calculations involving polymers of different lengths. Polymers with lengths from 20 to 1400 carbon atoms are considered. The systems are able to simulate friction between polymer surfaces and polymer against metal. The results we present are very preliminary and they...

  14. Chemoradiation in cervical cancer with cisplatin and high-dose rate brachytherapy combined with external beam radiotherapy. Results of a phase-II study

    Energy Technology Data Exchange (ETDEWEB)

    Strauss, H.G.; Laban, C.; Puschmann, D.; Koelbl, H. [Dept. of Gynecology, Martin-Luther Univ. Halle-Wittenberg (Germany); Kuhnt, T.; Pigorsch, S.; Dunst, J.; Haensgen, G. [Dept. of Radiotherapy, Martin-Luther Univ. Halle-Wittenberg (Germany)

    2002-07-01

    Background: In 1999, five randomized studies demonstrated that chemoradiation with cisplatin and low-dose rate (LDR) brachytherapy has a benefit in locally advanced cervical cancer and for surgically treated patients in high-risk situations. We evaluated the safety and efficacy of concomitant chemoradiation with cisplatin and high-dose rate (HDR) brachytherapy in patients with cervical cancer. Patients and Method: 27 patients were included in our phase-II trial: 13 locally advanced cases (group A) and 14 adjuvant-therapy patients in high-risk situations (group B). A definitive radiotherapy was performed with 25 fractions of external beam therapy (1.8 Gy per fraction/middle shielded after eleven fractions). Brachytherapy was delivered at HDR schedules with 7 Gy in point A per fraction (total dose 35 Gy) in FIGO Stages IIB-IIIB. The total dose of external and brachytherapy was 70 Gy in point A and 52-54 Gy in point B. All patients in stage IVA were treated without brachytherapy. Adjuvant radiotherapy was performed with external beam radiotherapy of the pelvis with 1.8 Gy single-dose up to 50.4 Gy. Brachytherapy was delivered at HDR schedules with two fractions of 5 Gy only in patients with tumor-positive margins or tumor involvement of the upper vagina. The chemotherapeutic treatment schedule provided six courses of cisplatin 40 mg/m{sup 2} weekly recommended in the randomized studies GOG-120 and -123. Results: A total of 18/27 patients (66.7%) completed all six courses of chemotherapy. Discontinuation of radiotherapy due to therapy-related morbidity was not necessary in the whole study group. G3 leukopenia (29.6%) was the only relevant acute toxicity. There were no differences in toxicity between group A and B. Serious late morbidity occurred in 2/27 patients (7.4%). 12/13 patients (92.3%) with IIB-IVA cervical cancer showed a complete response (CR). 13/14 adjuvant cases (92.8%) are free of recurrence (median follow up: 19.1 months). Conclusion: Concomitant

  15. Dosimetric results in implant and post-implant and low rate in brachytherapy prostate cancer with loose seeds and attached

    International Nuclear Information System (INIS)

    The objective is determine differences dosimetry statistics on the dosimetry of the implant and post-implant in brachytherapy of low rate with implants permanent in prostate using seed of 125-I loose and attached Both in lives and in the post-prostatic plans dosimetric coverage is good and restrictions in urethra and rectum for both groups of patients are met. Not migrating with joined is evident, as well as better dosimetric homogeneity. (Author)

  16. Hellenic Amateur Astronomy Association's activities: Preliminary results on Perseids 2010

    Science.gov (United States)

    Maravelias, G.

    2011-01-01

    Preliminary results on the Perseids 2010 are presented. Visual and video observations were obtained by the author and a first reduction of the visual data shows that a maximum of ZHR ~120 was reached during the night 12-13 of August 2010. Moreover, a video setup was tested (DMK camera and UFO Capture v2) and the results show that, under some limitations, valuable data can be obtained.

  17. Preliminary Simulation Results of the 23 June, 2001 Peruvian Tsunami

    Science.gov (United States)

    Titov, V. V.; Koshimura, S.; Ortiz, M.; Borrero, J.

    2001-12-01

    The tsunami generated by the June 23, 2001 Peruvian earthquake devastated a 50--km section of coast near the earthquake epicenter and was recorded on tide-gages throughout the Pacific. The coastal town of Camana sustained the most damage with tsunami waves penetrating up to 1--km inland and runup exceeding 5--m. The extreme local effects and widespread impact motivated modeling efforts to produce a realistic tsunami simulation of this event. Preliminary results were produced by the TIME center using two resident numerical models, TUNAMI--2 and MOST. Both models were used to produce preliminary simulations shortly after the earthquake, and first results were posted on the Internet a day after the event (http://www.pmel.noaa.gov/tsunami/peru_pmel.html). These numerical results aimed to quantify the magnitude of the tsunami and, to certain extent, to guide the post-tsunami survey. The first simulations have been revised using new data about the seismic source and the results of the post-tsunami survey. Measured inundation distances, flow depths, and runup along topographic transects are used to constrain the inundation model. Preliminary numerical analysis of tsunami inundation will be presented.

  18. Preliminary Results of the MOSES II 2015 Flight

    Science.gov (United States)

    Smart, Roy; Courrier, Hans; Kankelborg, Charles

    2016-05-01

    The Multi-Order Extreme Ultraviolet Spectrograph (MOSES) is a slitless spectrograph which aims to produce simultaneous spatial-spectral imaging of the solar transition region. This is accomplished through a multilayer concave diffraction grating which produces three images for the spectral orders m = 0, ± 1. The multilayer coating provides a narrow passband, dominated by Ne VII (46.5 nm), which allows the three images to be compared in order to determine line broadenings and identify explosive events in the Solar Transition Region. Here, we examine the preliminary results of MOSES II, the instrument’s second flight which was launched on a sounding rocket from White Sands Missile Range, NM in August 2015. We present the first images of the Sun in Ne VII since Skylab and the preliminary results of observed doppler shifts within an active region.

  19. Preliminary results of the echo-seeding experiment at SLAC

    Energy Technology Data Exchange (ETDEWEB)

    Xiang, D.; Colby, E.; Ding, Y.; Dunning, M.; Frederico, J.; Gilevich, S.; Hast, C.; Jobe, K.; McCormick, D.; Nelson, J.; Raubenheimer, T.O.; Soong, K.; Stupakov, G.; Szalata, Z.; Walz, D.; Weathersby, S.; Woodley, M.; Corlett, J.; Qiang, J.; Penn, G.; Prestemon, S.; Schlueter, R.; Venturini, M.; Wan, W.; Pernet, P-L.

    2010-05-23

    ECHO-7 is a proof-of-principle echo-enabled harmonic generation FEL experiment in the Next Linear Collider Test Accelerator (NLCTA) at SLAC. The experiment aims to generate coherent radiation at 318 nm and 227 nm, which are the 5th and 7th harmonic of the infrared seed laser. In this paper we present the preliminary results from the commissioning run of the completed experimental setup which started in April 2010.

  20. Intercomparison Of Spectroradiometers For Solar Spectral Irradiance Measurements. Preliminary Results.

    OpenAIRE

    Galleano, Roberto; ZAAIMAN Willem; MORABITO Paolo; Minuto, Alessandro; Spena, Angelo; Bartocci, Simona; Fucci, Raffaele; Leanza, Gianni; PAVANELLO Diego; VIRTUANI Alessandro; FASANARO Daniela; CATENA Mario; NORTON Matthew

    2011-01-01

    This paper describes the preliminary results of an intercomparison of spectroradiometers for direct (DNI) and global normal incidence (GNI) irradiance in the visible (VIS) and near infrared (NIR) region. Seven institutions and six spectroradiometers, representing different technologies and manufacturers were involved. All instruments were able to measure GNI; a restricted sub-group of four instruments had the possibility to also measure DNI when equipped with proper collimators. P...

  1. 9.4T Human MRI: Preliminary Results

    OpenAIRE

    VAUGHAN, THOMAS; DelaBarre, Lance; Snyder, Carl; Tian, Jinfeng; Akgun, Can; Shrivastava, Devashish; Liu, Wanzahn; Olson, Chris; Adriany, Gregor; Strupp, John; Andersen, Peter; Gopinath, Anand; Van de Moortele, Pierre-Francois; Garwood, Michael; Ugurbil, Kamil

    2006-01-01

    This work reports the preliminary results of the first human images at the new high-field benchmark of 9.4T. A 65-cm-diameter bore magnet was used together with an asymmetric 40-cm-diameter head gradient and shim set. A multichannel transmission line (transverse electromagnetic (TEM)) head coil was driven by a programmable parallel transceiver to control the relative phase and magnitude of each channel independently. These new RF field control methods facilitated compensation for RF artifacts...

  2. Preliminary Results of Lunar Topography by KAGUYA-LALT Mission

    Science.gov (United States)

    Araki, Hiroshi; Tazawa, Seiichi; Noda, Hirotomo; Migita, Emiko; Kamiya, Izumi; Kawano, Nobuyuki; Sasaki, Sho

    The Laser Altimeter (LALT) on board the main orbiter of KAGUYA (SELENE) started nominal observation on December 30, 2007 for mapping the lunar topography. As of March 31, 2008, LALT has obtained about 6.7 million topographic data and the return rate is 97%. Several qualifications of the data to produce reliable topography are now in progress. The present status and preliminary results are reported in this article.

  3. Preliminary results of Digital Pulse Shape Acquisition from Chimera

    Energy Technology Data Exchange (ETDEWEB)

    Alderighi, D.M.; Sechi, G. [INFN Milano and IASF, CNR, Milano (France); Anzalone, A.; Cavallaro, S.; Giustolisi, F.; Laguidara, E.; Lanzalone, G.; Porto, F. [Catania Univ., LNS and Dipartimento di Fisica (France); Bassini, R.; Boiano, C.; Guazzoni, P.; Russo, S.; Sassi, M.; Zetta, L. [Milano Univ., INFN and Dipartimento di Fisica (Italy); Cardella, G.; Defilippo, S.E.; Lanzano, G.; Paganod, A.; Papa, M.; Pirrone, S.; Politi, G. [Catania Univ., INFN and Dipartimento di Fisica (Italy); Geraci, E. [Bologna Univ., INFN and Dipartimento di Fisica (Italy)

    2003-07-01

    A 100 MS/s 14-bit Sampling Analog-to-Digital converter has been used to perform digital pulse-shape acquisition of signals collected from CHIMERA telescopes. The signals from a typical CHIMERA detection cell have been collected using both a standard CHIMERA electronic chain up to the amplifier, and a very simple analog front end, basically reduced to the preamplifier. The preliminary on-beam results are presented. (authors)

  4. Preliminary results of Digital Pulse Shape Acquisition from Chimera

    International Nuclear Information System (INIS)

    A 100 MS/s 14-bit Sampling Analog-to-Digital converter has been used to perform digital pulse-shape acquisition of signals collected from CHIMERA telescopes. The signals from a typical CHIMERA detection cell have been collected using both a standard CHIMERA electronic chain up to the amplifier, and a very simple analog front end, basically reduced to the preamplifier. The preliminary on-beam results are presented. (authors)

  5. Preliminary result of Indonesian strain map based on geodetic measurements

    Science.gov (United States)

    Susilo, Meilano, Irwan; Abidin, Hasanuddin Z.; Sapiie, Benyamin; Efendi, Joni; Wijanarto, Antonius B.

    2016-05-01

    GPS measurements from 1993 until 2014 across Indonesia region are providing longer time series at 2 - 3 millimetre-level precision from which surface velocity estimates are derived. In this study, we use this GPS velocities field to construct a crustal strain rate map and not including the physical model yet. In our preliminary result, we only compute the magnitude of the strain rate. The strain map is useful to construct the deformation model in Indonesia and to support the Indonesia datum.

  6. I Might Have Some Bad News: Disclosing Preliminary Pathology Results.

    Science.gov (United States)

    Roh, Michael H; Shuman, Andrew G

    2016-01-01

    Cytopathology is a subspecialty of pathology in which pathologists frequently interact directly with patients. Often this interaction is in the context of fine needle aspiration (FNA) procedures performed at the bedside by the cytopathologist or by another clinician with the cytopathologist present. Patient requests for preliminary results in such settings raise fundamental questions about professional scope of practice and communication of uncertainty that apply not merely to pathologists but to all clinicians. In certain settings, cytopathologists may share preliminary diagnostic impressions directly with patients. Essential to these conversations is the need to articulate potential uncertainty about both the diagnosis and next steps. In addition, the involvement and notification of the referring physician is obligatory, both for care coordination and to ensure that patients receive a consistent message. PMID:27550561

  7. HDR- and PDR-brachytherapy of soft tissue sarcoma in children

    International Nuclear Information System (INIS)

    Radiotherapy is part of the combined modality treatment of soft tissue sarcoma in children. Sparing of normal tissue, which is of special importance in children, is a potential advantage of brachytherapy in local treatment. There is only limited experience with brachytherapy in pediatric malignancies gained by a few centers with LDR techniques. Since 1991 twelve patients with tumors at different sites (pelvis, head and neck, orbit, chest wall, limbs) were treated with HDR- or PDR brachytherapy as part of the combined modality treatment according to the treatment protocols CWS-86/91 and CESS/CWS-REZ-91 at the departments of radiotherapy in Vienna, Kiel and Muenster. With eight patients brachytherapy was part of the recurrence treatment regime, with four patients part of the primary treatment alone or in combination with external beam therapy. In HDR treatment a dose of 15 to 43 Gy was delivered in 3 to 16 fractions, in PDR treatment 13 to 36 Gy in fractions of 1Gy/hour. Follow-up is 3 to 39 months (median 14 months), 7 children show no evidence of disease, with 9 the tumor is locally controlled and with 3 it progressed locoregionally. Although these preliminary results with HDR and PDR brachytherapy are encouraging further experience regarding long term survival, local control and late side effects must be gained prospectively and systematically in specialized collaborating centers

  8. Quality assurance in MR image guided adaptive brachytherapy for cervical cancer: Final results of the EMBRACE study dummy run

    DEFF Research Database (Denmark)

    Kirisits, Christian; Federico, Mario; Nkiwane, Karen;

    2015-01-01

    PURPOSE: Upfront quality assurance (QA) is considered essential when starting a multicenter clinical trial in radiotherapy. Despite the long experience gained for external beam radiotherapy (EBRT) trials, there are only limited audit QA methods for brachytherapy (BT) and none include the specific...... considered important for the evaluation of clinical, and dosimetric parameters and their relation to outcome. Contouring, treatment planning and dose reporting was evaluated and scored with a categorical scale of 1-10. Active feedback to centers was provided to improve protocol compliance and reporting. A...

  9. Brachytherapy applications and techniques

    CERN Document Server

    Devlin, Phillip M

    2015-01-01

    Written by the foremost experts in the field, this volume is a comprehensive text and practical reference on contemporary brachytherapy. The book provides detailed, site-specific information on applications and techniques of brachytherapy in the head and neck, central nervous system, breast, thorax, gastrointestinal tract, and genitourinary tract, as well as on gynecologic brachytherapy, low dose rate and high dose rate sarcoma brachytherapy, vascular brachytherapy, and pediatric applications. The book thoroughly describes and compares the four major techniques used in brachytherapy-intraca

  10. Interstitial prostate brachytherapy. LDR-PDR-HDR

    International Nuclear Information System (INIS)

    The first comprehensive overview of interstitial brachytherapy for the management of local or locally advanced prostate cancer. Written by an interdisciplinary team who have been responsible for the successful GEC-ESTRO/EAU Teaching Course. Discusses in detail patient selection, the results of different methods, the role of imaging, and medical physics issues. Prostate brachytherapy has been the subject of heated debate among surgeons and the proponents of the various brachytherapy methods. This very first interdisciplinary book on the subject provides a comprehensive overview of innovations in low dose rate (LDR), high dose rate (HDR), and pulsed dose rate (PDR) interstitial brachytherapy for the management of local or locally advanced prostate cancer. In addition to detailed chapters on patient selection and the use of imaging in diagnostics, treatment guidance, and implantation control, background chapters are included on related medical physics issues such as treatment planning and quality assurance. The results obtained with the different treatment options and the difficult task of salvage treatment are fully discussed. All chapters have been written by internationally recognized experts in their fields who for more than a decade have formed the teaching staff responsible for the successful GEC-ESTRO/EAU Prostate Brachytherapy Teaching Course. This book will be invaluable in informing residents and others of the scientific background and potential of modern prostate brachytherapy. It will also prove a useful source of up-to-date information for those who specialize in prostate brachytherapy or intend to start an interstitial brachytherapy service.

  11. Preliminary Results on Uncertainty Quantification for Pattern Analytics

    Energy Technology Data Exchange (ETDEWEB)

    Stracuzzi, David John [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Brost, Randolph [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Chen, Maximillian Gene [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Malinas, Rebecca [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Peterson, Matthew Gregor [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Phillips, Cynthia A. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Robinson, David G. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Woodbridge, Diane [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

    2015-09-01

    This report summarizes preliminary research into uncertainty quantification for pattern ana- lytics within the context of the Pattern Analytics to Support High-Performance Exploitation and Reasoning (PANTHER) project. The primary focus of PANTHER was to make large quantities of remote sensing data searchable by analysts. The work described in this re- port adds nuance to both the initial data preparation steps and the search process. Search queries are transformed from does the specified pattern exist in the data? to how certain is the system that the returned results match the query? We show example results for both data processing and search, and discuss a number of possible improvements for each.

  12. Clinical results of N0 tongue cancer treated with interstitial brachytherapy and management of occult cervical node metastases

    International Nuclear Information System (INIS)

    One hundred patients with T1-2N0 squamous cell carcinoma of the oral tongue were treated with interstitial brachytherapy between 1962 and 1983. The patients were followed for more than two years. The cumulative 5-year survival rate was 89% in T1N0 and 66% in T2N0. The relapse-free survival rate was 88% in T1N0 and 51% in T2N0. The 2-year local control rate in the primary site was 100% in T1N0 and 73% in T2N0. Cervical node metastases developed in 41% (T1N0: 33%, T2N0: 43%) of the patients. The 5-year survival rate for patients with subsequent cervical node metastases was 42%, and 92% for patients without them (p2 + PEP 6 mg/m2 x 5 days), the 2-year local control rate was 90%, the incidence of cervical node metastases was 38%, and the incidence of distant metastases was 15%. In 15 patients without chemotherapy, the corresponding figures were 93%, 20% and 7%. No statistically significant difference between the two groups was found. In conclusion, the development of cervical node metastasis worsens the prognosis of patients with T1-2N0 oral tongue cancer treated with interstitial brachytherapy. The combination with prophylactic neck irradiation or chemotherapy failed to decrease the incidence of cervical node metastases or improve survival rate. (J.P.N.)

  13. Preliminary Neutronics Results for the OECD MHTGR-350 Benchmark

    International Nuclear Information System (INIS)

    The benchmark problem is based on the MHTGR-350 reactor designed by General Atomics (GA). Phase I of the problem has three steady state exercises : Exercise 1 for neutronics stand alone with fixed cross-sections, Exercise 2 for thermal-fluids stand alone and Exercise 3 for coupled steady state. Phase II is defined for coupled transient cases. Phase III is defined to test the depletion capabilities of lattice physics codes. Phase III has two exercises : Exercise 1 for cold state and Exercise 2 for hot state. In this paper, a preliminary results for Exercise 1 of Phase I obtained by using CAPP code and the results for Phase III by McCARD code are presented. In this paper, some preliminary neutronics results for the OECD/NEA MHTGR-350 neutronics/thermal fluids coupled benchmark problem were presented and some of the global parameters for Phase I Exercise 1 were compared with those presented by INL research group. They showed a good agreement with each other. The results for Phase III were also reasonable. The benchmark is ongoing and more comparisons with the results of other research groups will be made as soon as they are available

  14. Erectile function after prostate brachytherapy

    International Nuclear Information System (INIS)

    Purpose: To evaluate erectile function after permanent prostate brachytherapy using a validated patient-administered questionnaire and to determine the effect of multiple clinical, treatment, and dosimetric parameters on penile erectile function. Methods and materials: A total of 226 patients with preimplant erectile function determined by the International Index of Erectile Function (IIEF) questionnaire underwent permanent prostate brachytherapy in two prospective randomized trials between February 2001 and January 2003 for clinical Stage T1c-T2c (2002 American Joint Committee on Cancer) prostate cancer. Of the 226 patients, 132 were potent before treatment and, of those, 128 (97%) completed and returned the IIEF questionnaire after brachytherapy. The median follow-up was 29.1 months. Potency was defined as an IIEF score of ≥13. The clinical, treatment, and dosimetric parameters evaluated included patient age; preimplant IIEF score; clinical T stage; pretreatment prostate-specific antigen level; Gleason score; elapsed time after implantation; preimplant nocturnal erections; body mass index; presence of hypertension or diabetes mellitus; tobacco consumption; the volume of the prostate gland receiving 100%, 150%, and 200% of the prescribed dose (V100/150/200); the dose delivered to 90% of the prostate gland (D90); androgen deprivation therapy; supplemental external beam radiotherapy (EBRT); isotope; prostate volume; planning volume; and radiation dose to the proximal penis. Results: The 3-year actuarial rate of potency preservation was 50.5%. For patients who maintained adequate posttreatment erectile function, the preimplant IIEF score was 29, and in patients with brachytherapy-related ED, the preimplant IIEF score was 25. The median time to the onset of ED was 5.4 months. After brachytherapy, the median IIEF score was 20 in potent patients and 3 in impotent patients. On univariate analysis, the preimplant IIEF score, patient age, presence of nocturnal erections

  15. Preliminary results on Niobium sputtered films inside TESLA type cavities

    International Nuclear Information System (INIS)

    In the framework of the ARES project and as a possible application for TESLA we realized a test set-up to study the deposition of Nb films inside a single-cell TESLA type cavity. The plasma confinement was obtained with two external coils centered on the cavity axis in a magnetic bottle configuration. The system is operational and optimization of the discharge parameters is in progress: samples are produced to test the film quality. This paper covers a brief description of the test set-up and preliminary results on samples (thickness, RRR, and XRD measurements). (author)

  16. Escherichia coli O26 IN RAW BUFFALO MILK: PRELIMINARY RESULTS

    Directory of Open Access Journals (Sweden)

    A. Rella

    2013-02-01

    Full Text Available Escherichia coli O26 is considered to be one of the most important food-borne pathogen. In this study, 120 buffalo milk samples collected in Lazio and in Apulia regions were tested for the presence of E. coli O26. One buffalo milk sample (0,8% tested positive for E. coli O26; the isolate was positive at the verocytotoxicity test and it showed resistance properties to different antimicrobial classes. These preliminary results highlight the need to monitor the foods of animal origin used for production and eaten by a wide range of persons, respect VTEC organism.

  17. Ruptured Achilles tendon--preliminary results of a new treatment.

    OpenAIRE

    Cetti, R.

    1988-01-01

    The preliminary results of a new treatment of ruptured Achilles tendons are presented. The new treatment consists of a new tendon suture and a new post-operative cast in which it is possible to make non-weight bearing movements of the ankle immediately after the operation. This makes it possible to walk the day after the operation, causes very little discomfort during the time in a cast, gives a quick return to normal mobility with normal plantar flexion strength and makes it possible to resu...

  18. V and V Efforts of Auroral Precipitation Models: Preliminary Results

    Science.gov (United States)

    Zheng, Yihua; Kuznetsova, Masha; Rastaetter, Lutz; Hesse, Michael

    2011-01-01

    Auroral precipitation models have been valuable both in terms of space weather applications and space science research. Yet very limited testing has been performed regarding model performance. A variety of auroral models are available, including empirical models that are parameterized by geomagnetic indices or upstream solar wind conditions, now casting models that are based on satellite observations, or those derived from physics-based, coupled global models. In this presentation, we will show our preliminary results regarding V&V efforts of some of the models.

  19. Preliminary experience on the implementation of computed tomography (CT)-based image guided brachytherapy (IGBT) of cervical cancer using high-dose-rate (HDR) Cobalt-60 source in University of Malaya Medical Centre (UMMC)

    Science.gov (United States)

    Jamalludin, Z.; Min, U. N.; Ishak, W. Z. Wan; Malik, R. Abdul

    2016-03-01

    This study presents our preliminary work of the computed tomography (CT) image guided brachytherapy (IGBT) implementation on cervical cancer patients. We developed a protocol in which patients undergo two Magnetic Resonance Imaging (MRI) examinations; a) prior to external beam radiotherapy (EBRT) and b) prior to intra-cavitary brachytherapy for tumour identification and delineation during IGBT planning and dosimetry. For each fraction, patients were simulated using CT simulator and images were transferred to the treatment planning system. The HR-CTV, IR-CTV, bladder and rectum were delineated on CT-based contouring for cervical cancer. Plans were optimised to achieve HR-CTV and IR-CTV dose (D90) of total EQD2 80Gy and 60Gy respectively, while limiting the minimum dose to the most irradiated 2cm3 volume (D2cc) of bladder and rectum to total EQD2 90Gy and 75Gy respectively. Data from seven insertions were analysed by comparing the volume-based with traditional point- based doses. Based on our data, there were differences between volume and point doses of HR- CTV, bladder and rectum organs. As the number of patients having the CT-based IGBT increases from day to day in our centre, it is expected that the treatment and dosimetry accuracy will be improved with the implementation.

  20. Preliminary Results Of A 600 Joules Small Plasma Focus Device

    Science.gov (United States)

    Lee, S. H.; Yap, S. L.; Wong, C. S.

    2009-07-01

    Preliminary results of a 600 J (3.7 μF, 18 kV) Mather type plasma focus device operated at low pressure will be presented. The discharge is formed between a solid anode with length of 6 cm and six symmetrically and coaxially arranged cathode rods of same lengths. The cathode base is profiled in a knife-edge design and a set of coaxial plasma gun are attached to it in order to initiate the breakdown and enhance the current sheath formation. The experiments have been performed in argon gas under a low pressure condition of several microbars. The discharge current and the voltage across the electrodes during the discharge are measured with high voltage probe and current coil. The current and voltage characteristics are used to determine the possible range of operating pressure that gives good focusing action. At a narrow pressure regime of 9.0±0.5 μbar, focusing action is observed with good reproducibility. Preliminary result of ion beam energy is presented. More work will be carried out to investigate the radiation output.

  1. High dose rate brachytherapy for oral cancer

    International Nuclear Information System (INIS)

    Brachytherapy results in better dose distribution compared with other treatments because of steep dose reduction in the surrounding normal tissues. Excellent local control rates and acceptable side effects have been demonstrated with brachytherapy as a sole treatment modality, a postoperative method, and a method of reirradiation. Low-dose-rate (LDR) brachytherapy has been employed worldwide for its superior outcome. With the advent of technology, high-dose-rate (HDR) brachytherapy has enabled health care providers to avoid radiation exposure. This therapy has been used for treating many types of cancer such as gynecological cancer, breast cancer, and prostate cancer. However, LDR and pulsed-dose-rate interstitial brachytherapies have been mainstays for head and neck cancer. HDR brachytherapy has not become widely used in the radiotherapy community for treating head and neck cancer because of lack of experience and biological concerns. On the other hand, because HDR brachytherapy is less time-consuming, treatment can occasionally be administered on an outpatient basis. For the convenience and safety of patients and medical staff, HDR brachytherapy should be explored. To enhance the role of this therapy in treatment of head and neck lesions, we have reviewed its outcomes with oral cancer, including Phase I/II to Phase III studies, evaluating this technique in terms of safety and efficacy. In particular, our studies have shown that superficial tumors can be treated using a non-invasive mold technique on an outpatient basis without adverse reactions. The next generation of image-guided brachytherapy using HDR has been discussed. In conclusion, although concrete evidence is yet to be produced with a sophisticated study in a reproducible manner, HDR brachytherapy remains an important option for treatment of oral cancer. (author)

  2. MR angiography of the abdominal aorta: Preliminary results

    International Nuclear Information System (INIS)

    Flowing blood can be demonstrated as bright signal in MR-imaging resulting in MR-angiography (MRA). This study presents the results of MRA using the 'time of flight'-effect in which projection angiograms along the longitudinal axis were established by a row of 2D-gradient echo (GE) images (FLASH) in breathhold technique. The method was proven in 5 normal volunteers and evaluated against DSA in 21 patients with aortic diseases. The preliminary results demonstrate a satisfactory flow signal in the normally perfused aorta; thus occlusions, stenoses, and aneurysms could be defined clearly. In smaller vessels the signal was still insufficient. Diagnostic problems of vascular overlapping can be solved in most cases by rotating the angiograms, and by additional analysis of individual 2D-GE images. In the present form the quality of MRA is still inferior to that of DSA. (orig.)

  3. Preliminary Results Of LOCA Problem For APR1400 Reactor

    International Nuclear Information System (INIS)

    Several features of NPP with APR1400 nuclear reactor during a loss of coolant accident (LOCA) are investigated in this study. The report describes some main design characteristics of an engineering safety systems of APR1400 and the thermal hydraulic calculation results for steady-state using MARS and RELAP/SCDAPSIM codes. Large Break LOCA accident has been analyzed and evaluated based on acceptable criteria for ECCS given by US NRC. The results from cold leg break LOCA with broken area of 0.0465 m2 in case of high pressure safety injection system (HPSI) failed to operate or 2 and 4 HPSI pumps are activated. The preliminary results of this work is a part of collaboration between INST researchers and KAERI experts in using RELAP tool for safety analysis of NPPs. (author)

  4. Factors Associated With Optimal Long-Term Cosmetic Results in Patients Treated With Accelerated Partial Breast Irradiation Using Balloon-Based Brachytherapy

    International Nuclear Information System (INIS)

    Purpose: To evaluate factors associated with optimal cosmetic results at 72 months for early-stage breast cancer patients treated with Mammosite balloon-based accelerated partial breast irradiation (APBI). Methods and Materials: A total of 1,440 patients (1,449 cases) with early-stage breast cancer undergoing breast-conserving therapy were treated with balloon-based brachytherapy to deliver APBI (34 Gy in 3.4-Gy fractions). Cosmetic outcome was evaluated at each follow-up visit and dichotomized as excellent/good (E/G) or fair/poor (F/P). Follow-up was evaluated at 36 and 72 months to establish long-term cosmesis, stability of cosmesis, and factors associated with optimal results. Results: The percentage of evaluable patients with excellent/good (E/G) cosmetic results at 36 months and more than 72 months were 93.3% (n = 708/759) and 90.4% (n = 235/260). Factors associated with optimal cosmetic results at 72 months included: larger skin spacing (p = 0.04) and T1 tumors (p = 0.02). Using multiple regression analysis, the only factors predictive of worse cosmetic outcome at 72 months were smaller skin spacing (odds ratio [OR], 0.89; confidence interval [CI], 0.80–0.99) and tumors greater than 2 cm (OR, 4.96, CI, 1.53–16.07). In all, 227 patients had both a 36-month and a 72-month cosmetic evaluation. The number of patients with E/G cosmetic results decreased only slightly from 93.4% at 3 years to 90.8% (p = 0.13) at 6 years, respectively. Conclusions: APBI delivered with balloon-based brachytherapy produced E/G cosmetic results in 90.4% of cases at 6 years. Larger tumors (T2) and smaller skin spacing were found to be the two most important independent predictors of cosmesis.

  5. The use of TLDs for brachytherapy dosimetry

    International Nuclear Information System (INIS)

    Thermoluminescent dosimeters (TLDs) are routinely used to measure the dose around brachytherapy sources due to their small size and high precision. This work presents a concise overview of the use of LiF:Mg,Ti TLDs for brachytherapy dosimetry including the experimental procedures required to achieve high-precision measurements as well as new results regarding the intrinsic energy dependence with some of the commonly used brachytherapy sources. Equations to correct TLD light output to air kerma are outlined and a description of the method to determine the intrinsic energy dependence is presented. For the intrinsic energy dependence investigation, a review of previously published results is presented as well as new experimental results using 125I, 103Pd, 192Ir, and miniature x-ray brachytherapy sources at the University of Wisconsin Medical Radiation Research Center (UWMRRC). The results of these experiments are consistent with previous work and give valuable insight to investigators using TLDs for brachytherapy measurements. - Highlights: • Brachytherapy measurements with LiF:Mg,Ti TLDs performed. • Intrinsic energy dependence for several brachytherapy sources determined. • New LiF:Mg,Ti energy dependence results compared with previous data for x-ray beams. • Uncertainty of LiF:Mg,Ti TLD measurements reviewed

  6. Implications of Scheduled ITC Reversion for RPS Compliance: Preliminary Results

    Energy Technology Data Exchange (ETDEWEB)

    Lowder, Travis; Miller, John; O' Shaughnessy, Eric; Heeter, Jenny

    2015-09-14

    This poster presents DRAFT initial results of a forthcoming NREL analysis. The analysis investigates the impacts of the scheduled investment tax credit (ITC) reversion from 30 percent to 10 percent for certain solar photovoltaic projects. Specifically, it considers whether the reversion will result in increased use of alternative compliance payments (ACPs) in lieu of solar renewable energy credits (SRECs) for renewable portfolio standard (RPS) compliance. The analysis models the effect of a 10 percent ITC on power purchase agreement (PPA) prices for non-residential systems in the eight states with solar carve-outs and solar ACPs. Our preliminary results suggest that states will likely install sufficient capacity to meet long-term targets through SRECs rather than ACPs following the ITC reversion. However, the analysis shows that the ITC reversion could affect project economics such that capacity shortfalls in certain states could temporarily increase the use of ACPs. NREL anticipates publishing a full report of this analysis in fall 2015. credits (SRECs) for renewable portfolio standard (RPS) compliance. The analysis models the effect of a 10 percent ITC on power purchase agreement (PPA) prices for non-residential systems in the eight states with solar carve-outs and solar ACPs. Our preliminary results suggest that states will likely install sufficient capacity to meet long-term targets through SRECs rather than ACPs following the ITC reversion. However, the analysis shows that the ITC reversion could affect project economics such that capacity shortfalls in certain states could temporarily increase the use of ACPs. NREL anticipates publishing a full report of this analysis in fall 2015.

  7. Preliminary results on epidemiology of Coconut Lethal Yellowing in Ghana

    Directory of Open Access Journals (Sweden)

    Bonnot François

    2009-03-01

    Full Text Available Epidemiological studies are of major importance in understanding the determinants of plant diseases in order to control the risks of their spreading. A research programme on the epidemiology of coconut lethal yellowing, or Cape Saint Paul Wilt Disease (CSPWD, in Ghana was launched in March 2007. The objective was to characterize the distribution and spread of the disease in space and time at various scales, and their relation with the environment. This article presents the general strategy used to evaluate the incidence of CSPWD along with the environmental, ecological and agronomical variables at regional level. A survey was undertaken on 1,166 plots of Coconut Sector Development Project (CSDP planted with Malayan Yellow Dwarf (MYD × Vanuatu Tall (VTT hybrids in Western Region and Central Region. Preliminary results on the distribution of CSPWD and outside variables at regional scale, along with their relations, are given.

  8. Ex vivo accommodation simulator II: concept and preliminary results

    Science.gov (United States)

    Ehrmann, Klaus; Ho, Arthur; Parel, Jean-Marie

    2004-07-01

    A new instrument was developed to simulate the accommodation of excised human and animal crystalline lenses. The sclera is attached to 8 radially arranged translation stages and dissected into 8 segments. Change in accommodation is simulated by pulling and releasing the scleral segments, varying the load on the zonules and the capsular bag. Each translation stage is equipped with a sensitive force transducer for simultaneous recording of load and displacement. Additionally, changes in optical power, lens diameter, lens thickness and lens shape can be observed and quantified while the lens is stretched and released. The sensitivity and accuracy of the instrument was verified using steel springs and elastic bands. Preliminary results from sensitivity testing and instrument calibration are presented.

  9. Whole-body imaging at 7T: preliminary results.

    Science.gov (United States)

    Vaughan, J Thomas; Snyder, Carl J; DelaBarre, Lance J; Bolan, Patrick J; Tian, Jinfeng; Bolinger, Lizann; Adriany, Gregor; Andersen, Peter; Strupp, John; Ugurbil, Kamil

    2009-01-01

    The objective of this study was to investigate the feasibility of whole-body imaging at 7T. To achieve this objective, new technology and methods were developed. Radio frequency (RF) field distribution and specific absorption rate (SAR) were first explored through numerical modeling. A body coil was then designed and built. Multichannel transmit and receive coils were also developed and implemented. With this new technology in hand, an imaging survey of the "landscape" of the human body at 7T was conducted. Cardiac imaging at 7T appeared to be possible. The potential for breast imaging and spectroscopy was demonstrated. Preliminary results of the first human body imaging at 7T suggest both promise and directions for further development. PMID:19097214

  10. Preliminary results from LADEE's Neutral Mass Spectrometer (NMS)

    Science.gov (United States)

    Benna, Mehdi; Mahaffy, Paul; Hodges, Richard

    2014-05-01

    The Neutral Mass Spectrometer (NMS) of the Lunar Atmosphere and Dust Environment Explorer (LADEE) Mission is a high sensitivity quadrupole mass spectrometer designed to measure the composition and variability of the tenuous lunar atmosphere. The instrument has been observing the lunar exosphere since 10/17/2013, initially from a near circular 250 km altitude orbit and since 11/11/2013 from an elliptical orbit that reaches to 30-60 km altitude near the sunrise terminator. During its first four months in orbit, the NMS instrument successfully detected exospheric helium, argon and neon and mapped their spatial and temporal variability. Furthermore, the NMS instrument was able to establish new upper limits for many other exospheric species either sputtered or thermally evolved from the lunar surface. This talk will summarize these preliminary results from the NMS measurements.

  11. Preliminary Test Results for the MICE Spectrometer Superconducting Solenoids

    Energy Technology Data Exchange (ETDEWEB)

    Virostek, Steve P.; Green, Michael A; Li, Derun; Zisman, Michael S.; Wang, S.T.; Wahrer, R.; Taylor, Clyde; Lu, X.; Chen, J. Y.; Wang, Mimi; Juang, Tiki

    2008-08-02

    This report describes the MICE spectrometer solenoids as built. Each magnet consists of five superconducting coils. Two coils are used to tune the beam going from or to the MICE spectrometer from the rest of the MICE cooling channel. Three spectrometer coils (two end coils and a long center coil) are used to create a uniform 4 T field (to {+-}0.3 percent) over a length of 1.0 m within a diameter of 0.3 m. The three-coil spectrometer set is connected in series. The two end coils use small power supplies to tune the uniform field region where the scintillating fiber tracker is located. This paper will present the results of the preliminary testing of the first spectrometer solenoid.

  12. Preliminary Test Results for the MICE Spectrometer Superconducting Solenoids

    International Nuclear Information System (INIS)

    This report describes the MICE spectrometer solenoids as built. Each magnet consists of five superconducting coils. Two coils are used to tune the beam going from or to the MICE spectrometer from the rest of the MICE cooling channel. Three spectrometer coils (two end coils and a long center coil) are used to create a uniform 4 T field (to ±0.3 percent) over a length of 1.0 m within a diameter of 0.3 m. The three-coil spectrometer set is connected in series. The two end coils use small power supplies to tune the uniform field region where the scintillating fiber tracker is located. This paper will present the results of the preliminary testing of the first spectrometer solenoid

  13. Preliminary Results of the CASCADE Hidden Sector Photon Search

    CERN Document Server

    Woollett, Nathan; Burt, Graeme; Chattopadhyay, Swapan; Dainton, John; Dexter, Amos; Goudket, Phillipe; Jenkins, Michael; Kalliokoski, Matti; Moss, Andrew; Pattalwar, Shrikant; Thakker, Trina; Williams, Peter

    2015-01-01

    Light shining through a wall experiments can be used to make measurements of photon-WISP couplings. The first stage of the CASCADE experiment at the Cockcroft Institute of Accelerator Science and Technology is intended to be a proof-of-principle experiment utilising standard microwave technologies to make a modular, cryogenic HSP detector to take advantage of future high-power superconducting cavity tests. In these proceedings we will be presenting the preliminary results of the CASCADE LSW experiment showing a peak expected exclusion of $1.10 \\times 10^{-8}$ in the mass range from 1.96$\\mu$eV to 5.38$\\mu$eV, exceeding current limits.

  14. Preliminary results of the first paleontologic investigations in Uruguayan Antarctica

    International Nuclear Information System (INIS)

    Preliminary results of the first Uruguayan paleontollogic and biostratigraphical investigations in Antartica are presented. The field work was performed in fildes Peninsula, King George Island, near Uruguayan station Base Cientifica Antarctica Artigas.Some fossiliferous outcrops were geologic and paleontologically analyzed, among them Fossil Hills, situated in the center part of the peninsula, in front of Ardley Island, between the chinese and chilean stations.This hill is composed of fossil bearing piroclastic and epiclastic rocks, assigned to the fossil Hill Fm. Vegetal remains(petrified wood and leaf impronts) were observed and collected in this unit and it is remarkable the presence of Nothofagus sp. and invertebrate trace fossils, Cochlichmus isp and Helminthopsis isp.The depositional environment deduced from the fossil association in lacustrine, under a warm and humid climate.In the same deposits, other investigators have collected aquatic and ratite bird trace fossils. Paleontologic evidence is not contradictory with the Eocene age previously proposed for the studied deposits. (author)

  15. Status of EUROBALL IV and preliminary physics results

    International Nuclear Information System (INIS)

    Complete text of publication follows. The study of nuclear structure at the limits of angular momentum and isospin is only possible with very selective and powerful detection setups. The EUROBALL γ-ray spectrometer and the many associated ancillary detectors have been designed for that purpose. In its fourth phase, EUROBALL includes an inner BGO ball which works, with the Ge detectors and their suppression shields, like a multiplicity filter and a calorimeter and improves the selectivity of the device. EUROBALL IV is in operation at IReS-Strasbourg since june 1999. More than 20 experiments have already been performed with this very efficient instrument and preliminary results of some of them will be presented in this talk. (author)

  16. The emerging role of high-dose-rate (HDR) brachytherapy as monotherapy for prostate cancer

    International Nuclear Information System (INIS)

    High-dose-rate (HDR) brachytherapy as monotherapy is a comparatively new brachytherapy procedure for prostate cancer. In addition to the intrinsic advantages of brachytherapy, including radiation dose concentration to the tumor and rapid dose fall-off at the surrounding normal tissue, HDR brachytherapy can yield a more homogeneous and conformal dose distribution through image-based decisions for source dwell positions and by optimization of individual source dwell times. Indication can be extended even to T3a/b or a part of T4 tumors because the applicators can be positioned at the extracapsular lesion, into the seminal vesicles, and/or into the bladder, without any risk of source migration or dropping out. Unlike external beam radiotherapy, with HDR brachytherapy inter-/intra-fraction organ motion is not problematic. However, HDR monotherapy requires patients to stay in bed for 1-4 days during hospitalization, even though the actual overall treatment time is short. Recent findings that the α/β value for prostate cancer is less than that for the surrounding late-responding normal tissue has made hypofractionation attractive, and HDR monotherapy can maximize this advantage of hypofractionation. Research on HDR monotherapy is accelerating, with a growing number of publications reporting excellent preliminary clinical results due to the high 'biologically effective dose (BED)' of >200 Gy. Moreover, the findings obtained for HDR monotherapy as an early model of extreme hypofractionation tend to be applied to other radiotherapy techniques such as stereotactic radiotherapy. All these developments point to the emerging role of HDR brachytherapy as monotherapy for prostate cancer. (author)

  17. Benchmarking the Integration of WAVEWATCH III Results into HAZUS-MH: Preliminary Results

    Science.gov (United States)

    Berglund, Judith; Holland, Donald; McKellip, Rodney; Sciaudone, Jeff; Vickery, Peter; Wang, Zhanxian; Ying, Ken

    2005-01-01

    The report summarizes the results from the preliminary benchmarking activities associated with the use of WAVEWATCH III (WW3) results in the HAZUS-MH MR1 flood module. Project partner Applied Research Associates (ARA) is integrating the WW3 model into HAZUS. The current version of HAZUS-MH predicts loss estimates from hurricane-related coastal flooding by using values of surge only. Using WW3, wave setup can be included with surge. Loss estimates resulting from the use of surge-only and surge-plus-wave-setup were compared. This benchmarking study is preliminary because the HAZUS-MH MR1 flood module was under development at the time of the study. In addition, WW3 is not scheduled to be fully integrated with HAZUS-MH and available for public release until 2008.

  18. Locally advanced cervical cancer: Should intensity-modulated radiotherapy replace brachytherapy?; Complement d'irradiation dans le cancer du col de l'uterus localement evolue: curietherapie uterovaginale ou radiotherapie conformationnelle avec modulation d'intensite?

    Energy Technology Data Exchange (ETDEWEB)

    Mazeron, R.; Gilmore, J.; Khodari, W.; Dumas, I.; Haie-Meder, C. [Service de radiotherapie, institut de cancerologie Gustave-Roussy, 114, rue edouard-Vaillant, 94805 Villejuif cedex (France)

    2011-10-15

    Intensity-modulated conformal radiotherapy (IMRT) is booming as treatment of locally advanced cervical cancer. This technique reduces the doses delivered to organs at risk and, by analogy to the irradiation of prostate cancer, opens the door to the possibility of dose escalation to levels close or similar to those achieved by brachytherapy. To date, several studies comparing IMRT with brachytherapy have been published, often methodologically flawed, concluding sometimes that both techniques are comparable. These results should be taken with extreme caution and should not overshadow the recent advances in brachytherapy with the use of 3D imaging and optimization. Preliminary works also showed that the combination of 3D optimized brachytherapy with IMRT could improve the management of the local disease especially for lesions poorly covered by intracavitary techniques. (authors)

  19. Preliminary on-orbit results of trigger system for DAMPE

    Science.gov (United States)

    Zhang, Yongqiang; Chang, Jin; Guo, Jian hua; Dong, TieKuang; Liu, Yang

    2016-07-01

    The Dark Matter Particle Explorer (DAMPE), Chinese first high energy cosmic ray explorer in space, has been successfully launched at Jiuquan Satellite Launch Center, with the mission of searching dark matter particle. Large energy range for electron/gamma, good energy resolution, and excellent PID ability, make DAMPE to be the most promising detector so far to find the signal of dark matter. DAMPE consists of four sub-detectors: Plastic Scintillation detector, Silicon-Tungsten tracker, BGO calorimeter and Neutron detector. The hit signals generated by the BGO calorimeter and the trigger board (in DAQ) constitute the trigger system of DAMPE, which will generate trigger signals for the four sub-detectors to start data acquisition. The trigger system reduces the trigger rates on orbit from about 1kHz to 70~100Hz, that releases the stress of DAQ transmitting data to ground. In this paper, we will introduce the trigger system of DAMPE, and present some preliminary on-orbit results e.g. trigger efficiency, together with the beam test results at CERN and the simulation results as comparison.

  20. Uranium and thorium recovery in thorianite ore-preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Gaiotte, Joao V.M. [Universidade Federal de Alfenas, Pocos de Caldas, MG (Brazil); Villegas, Raul A.S.; Fukuma, Henrique T., E-mail: rvillegas@cnen.gov.br, E-mail: htfukuma@cnen.gov.br [Comissao Nacional de Energia Nuclear (CNEN), Pocos de Caldas, MG (Brazil). Lab. de Pocos de Caldas

    2011-07-01

    This work presents the preliminary results of the studies aiming to develop a hydrometallurgical process to produce uranium and thorium concentrates from thorianite ore from Amapa State, Brazil. This process comprises two major parts: acid leaching and Th/U recovery using solvent extraction strategies. Thorianite ore has a typical composition of 60 - 70% of thorium, 8 - 10% lead and 7 - 10% uranium. Sulfuric acid leaching operational conditions were defined as follows: acid/ore ratio 7.5 t/t, ore size below 65 mesh (Tyler), 2 hours leaching time and temperature of 100 deg C. Leaching tests results showed that uranium and thorium recovery exceeded 95%, whereas 97% of lead ore content remained in the solid form. Uranium and thorium simultaneous solvent extraction is necessary due to high sulfate concentration in the liquor obtained from leaching, so the Primene JM-T primary anime was used for this extraction step. Aqueous raffinate from extraction containing sulfuric acid was recycled to the leaching step, reducing acid uptake around 60%, to achieve a net sulfuric acid consumption of 3 t/t of ore. Uranium and thorium simultaneous stripping was performed using sodium carbonate solution. In the aqueous stripped it was added sulfuric acid at pH 1.5, followed by a second solvent extraction step using the tertiary amine Alamine 336. The following stripping step was done with a solution of sodium chloride, resulting in a final solution of 23 g L-1 uranium. (author)

  1. HDR endobronchial brachytherapy

    International Nuclear Information System (INIS)

    Introduction: This is a restrospective study to review the palliation rate, survival rate and complications of high dose rate (HDR) endobronchial brachytherapy in the treatment of airway obstruction of recurrent lung cancer or metastasis. Material and method: Between september 1992 and may 1995 it has been treated forty (40) patients with endobronchial lesions. 38 patients with unique endobronchial lesion and 2 patients with double lesions. 32 had primary lung carcinoma: 27 with epidermoid carcinoma (1 bilateral), 2 with adenocarcinoma, 1 with small cell carcinoma, 1 with undifferentiated carcinoma and 1 with primary double (adenocarcinoma and large cell carcinoma). 8 patients had endobronchial metastasis: 2 hypernefroma, 3 breast carcinoma, 1 colon cancer, 1 seminoma and 1 Ewing sarcoma. 33 patients were male (82.5%) and 7 female (17.5%). The treatment was carried out in three weekly fractions with a dose of 750 cGy per fraction at 1 cm from the source. An afterloaded equipment was used (microselectron HDR). The most frequent sites were: right main stem bronchus 9 patients (22.5%), left main stem bronchus 7 patients (17.5%), and right middle bronchus 5 patients (12.5%). Results and discussion: The endoscopic global response assessed after three weeks was of 70%. The symptomatic response was 95% hemoptysis control, 87% dysnea control, 80% obstructive pneumonia control and 70% cough control. The minimum follow up was one year. There were three cases of massive hemoptysis and three patients developed local recurrence (one received a second brachytherapy treatment). Conclusion: HDR brachytherapy offers an excellent long term palliation for any of the obstructing symptoms, being effective in more than 70% in patients with recurrence lung primary cancer or endobronchial metastasis with a low complication rate

  2. InRidge program: Preliminary results from the first cruise

    Digital Repository Service at National Institute of Oceanography (India)

    Mukhopadhyay, R.; Murthy, K.S.R.; Iyer, S.D.; Rao, M.M.M.; Banerjee, R.; Subrahmanyam, A.S.; Shirodkar, P.V.; Ghose, I.

    thicknesses and fresh basaltic nuclei. Preliminary studies indicate a possible mixed hydrothermal and hydrogenous source for these nodules. The water column was also sampled at the Vema and Vityaz transform fault areas....

  3. The American Brachytherapy Society recommendations for low-dose-rate brachytherapy for carcinoma of the cervix

    International Nuclear Information System (INIS)

    Purpose: This report presents guidelines for using low-dose-rate (LDR) brachytherapy in the management of patients with cervical cancer. Methods: Members of the American Brachytherapy Society (ABS) with expertise in LDR brachytherapy for cervical cancer performed a literature review, supplemented by their clinical experience, to formulate guidelines for LDR brachytherapy of cervical cancer. Results: The ABS strongly recommends that radiation treatment for cervical carcinoma (with or without chemotherapy) should include brachytherapy as a component. Precise applicator placement is essential for improved local control and reduced morbidity. The outcome of brachytherapy depends, in part, on the skill of the brachytherapist. Doses given by external beam radiotherapy and brachytherapy depend upon the initial volume of disease, the ability to displace the bladder and rectum, the degree of tumor regression during pelvic irradiation, and institutional practice. The ABS recognizes that intracavitary brachytherapy is the standard technique for brachytherapy for cervical carcinoma. Interstitial brachytherapy should be considered for patients with disease that cannot be optimally encompassed by intracavitary brachytherapy. The ABS recommends completion of treatment within 8 weeks, when possible. Prolonging total treatment duration can adversely affect local control and survival. Recommendations are made for definitive and postoperative therapy after hysterectomy. Although recognizing that many efficacious LDR dose schedules exist, the ABS presents suggested dose and fractionation schemes for combining external beam radiotherapy with LDR brachytherapy for each stage of disease. The dose prescription point (point A) is defined for intracavitary insertions. Dose rates of 0.50 to 0.65 Gy/h are suggested for intracavitary brachytherapy. Dose rates of 0.50 to 0.70 Gy/h to the periphery of the implant are suggested for interstitial implant. Use of differential source activity or

  4. The Myres Hill remote sensing intercomparison study: preliminary results

    Science.gov (United States)

    Clive, P. J. M.; Chindurza, I.; Ravey, I.; Bass, J.; Boyle, R. J.; Jones, P.; Lang, S. J.; Bradley, S.; Hay, L.; Oldroyd, A.; Stickland, M.

    2008-05-01

    Two remote sensing techniques (SODAR and LIDAR) have been developed for measuring wind speed and turbulence from ground level up to altitudes of 300 m or higher. Although originally developed in the defence sector, these techniques are now generating considerable interest in the renewable energy and meteorological sectors. Despite the benefits of these instruments they are not yet generally accepted for due diligence measurements by wind energy developers and financial institutions. There is a requirement for a series of independent assessments of these new metrology techniques, comparing their measurements with the approved cup-type anemometer readings. This is being addressed at TUV NEL's Myres Hill wind turbine test site in a measurement programme supported by the DIUS National Measurement Systems Measurement for Innovators scheme and a consortium of 21 industrial collaborators. Data from SODAR and LIDAR systems are being compared with results from cup-type anemometers mounted at different heights on an 80m meteorological mast. An ultrasonic sensor is also mounted on the mast. The objective of the test programme is to assess the effectiveness of SODAR and LIDAR wind speed measurement techniques under different operating regimes and atmospheric conditions. Results from the measurements will provide definitive data on the performance of the remote wind speed sensing techniques under test on complex terrain typical of many wind farm sites. Preliminary measurements based on data acquired during the initial measurement campaign are presented.

  5. Preliminary experimental results from a linear reciprocating magnetic refrigerator prototype

    International Nuclear Information System (INIS)

    A linear reciprocating magnetic refrigerator prototype was designed and built with the aid of an industrial partner. The refrigerator is based on the Active Magnetic Regenerative cycle, and exploits two regenerators working in parallel. The active material is Gadolinium in plates, 0.8 mm thick, for a total mass of 0.36 kg. The device is described and results about magnetic field and temperature span measurements are presented. The designed permanent magnet structure, based on an improved cross-type arrangement, generates a maximum magnetic field intensity of 1.55 T in air, over a gap of (13 × 50 × 100) mm3. The maximum temperature span achieved is 5.0 K, in a free run condition. -- Highlights: ► We give preliminary results from a linear reciprocating magnetic refrigerator prototype. ► The design is intended to process visualization and investigation. ► The prototype behavior gives us various suggestions to improve its general performance

  6. Magnetic resonance imaging urodynamics: technique development and preliminary results

    Directory of Open Access Journals (Sweden)

    Gustavo Borghesi

    2006-06-01

    Full Text Available OBJECTIVES: In this preliminary study we report the development of the video urodynamic technique using magnetic resonance imaging (MRI. MATERIALS AND METHODS: We studied 6 women with genuine stress urinary incontinence, diagnosed by history and physical examination. Urodynamic examination was performed on multichannel equipment with the patient in the supine position. Coughing and Valsalva maneuvers were performed at volumes of 150, 250 and 350 mL. Simultaneously, MRI was carried out by using 1.5 T GE Signa CV/i high-speed scanner with real time fluoroscopic imaging possibilities. Fluoroscopic imaging was accomplished in the corresponding planes with T2-weighted single shot fast spin echo sequences at a speed of about 1 frame per second. Both studies were recorded and synchronized, resulting in a single video urodynamic examination. RESULTS: Dynamic MRI with cine-loop reconstruction of 1 image per second demonstrated the movement of all compartment of the relaxed pelvis during straining with the concomitant registration of abdominal and intravesical pressures. In 5 patients, urinary leakage was demonstrated during straining and the Valsalva leak point pressure (VLPP was determined as the vesical pressure at leak subtracted from baseline bladder pressure. Mean VLPP was 72.6 cm H2O (ranging from 43 to 122 cm H2O. CONCLUSIONS: The concept of MRI video urodynamics is feasible. In a clinical perspective, practical aspects represent a barrier to daily use and it should be recommended for research purposes.

  7. In situ photoimmunotherapy for melanoma: preliminary clinical results

    Science.gov (United States)

    Naylor, Mark F.; Nordquist, Robert E.; Teauge, T. Kent; Perry, Lisa A.; Chen, Wei R.

    2006-02-01

    Although melanoma accounts for only 4% of skin cancer cases, it causes 79% of all skin cancer deaths. Patients with metastatic melanoma have a poor prognosis, and long term survival is only about 5% [1, 2]. Conventional therapies such as surgery and radiation therapy usually do not cure stage III or stage IV melanoma, while traditional chemotherapy is primarily palliative. Over the last decade we have been developing new methods for treating solid tumors like melanoma, first in animal models and now in humans. We present here preliminary results from a new technique that utilizes a combination of laser stimulation and drug therapy to stimulate brisk immunological responses in cases of advanced melanoma with cutaneous metastases. A high-power, near-infrared diode laser (805 nm) is used to kill tumors in situ and a topical toll-like receptor agonist (imiquimod cream, 5%) is used to intensify the resulting immunological response. This is essentially an in situ, tumor vaccine approach to treating solid tumors.

  8. The Myres Hill remote sensing intercomparison study: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Clive, P J M; Chindurza, I [SgurrEnergy Ltd, 79 Coplaw Street, Glasgow G42 7JG, Scotland (United Kingdom); Ravey, I; Bass, J [RES Group Ltd, James Blyth House, 7000 Academy Park, Glasgow, Scotland (United Kingdom); Boyle, R J; Jones, P [TUV NEL Ltd, East Kilbride, Glasgow G75 0QF, Scotland (United Kingdom); Lang, S J [Sustainable Energy Research Group, University College Cork (Ireland); Bradley, S [Mighty River Power, Level 14, 23-29 Albert Street, Auckland (New Zealand); Hay, L [Garrad Hassan and Partners Ltd, 2064 Maryhill Road, Glasgow G20 0AB, Scotland (United Kingdom); Oldroyd, A [Oldbaum Services Ltd, Schoolhouse, Brig o' Turk, Callander, Scotland (United Kingdom); Stickland, M [University of Strathclyde, 16 Richmond Street, Glasgow G1 1XQ, Scotland (United Kingdom)], E-mail: peter.clive@sgurrenergy.com

    2008-05-01

    Two remote sensing techniques (SODAR and LIDAR) have been developed for measuring wind speed and turbulence from ground level up to altitudes of 300 m or higher. Although originally developed in the defence sector, these techniques are now generating considerable interest in the renewable energy and meteorological sectors. Despite the benefits of these instruments they are not yet generally accepted for due diligence measurements by wind energy developers and financial institutions. There is a requirement for a series of independent assessments of these new metrology techniques, comparing their measurements with the approved cup-type anemometer readings. This is being addressed at TUV NEL's Myres Hill wind turbine test site in a measurement programme supported by the DIUS National Measurement Systems Measurement for Innovators scheme and a consortium of 21 industrial collaborators. Data from SODAR and LIDAR systems are being compared with results from cup-type anemometers mounted at different heights on an 80m meteorological mast. An ultrasonic sensor is also mounted on the mast. The objective of the test programme is to assess the effectiveness of SODAR and LIDAR wind speed measurement techniques under different operating regimes and atmospheric conditions. Results from the measurements will provide definitive data on the performance of the remote wind speed sensing techniques under test on complex terrain typical of many wind farm sites. Preliminary measurements based on data acquired during the initial measurement campaign are presented.

  9. The Myres Hill remote sensing intercomparison study: preliminary results

    International Nuclear Information System (INIS)

    Two remote sensing techniques (SODAR and LIDAR) have been developed for measuring wind speed and turbulence from ground level up to altitudes of 300 m or higher. Although originally developed in the defence sector, these techniques are now generating considerable interest in the renewable energy and meteorological sectors. Despite the benefits of these instruments they are not yet generally accepted for due diligence measurements by wind energy developers and financial institutions. There is a requirement for a series of independent assessments of these new metrology techniques, comparing their measurements with the approved cup-type anemometer readings. This is being addressed at TUV NEL's Myres Hill wind turbine test site in a measurement programme supported by the DIUS National Measurement Systems Measurement for Innovators scheme and a consortium of 21 industrial collaborators. Data from SODAR and LIDAR systems are being compared with results from cup-type anemometers mounted at different heights on an 80m meteorological mast. An ultrasonic sensor is also mounted on the mast. The objective of the test programme is to assess the effectiveness of SODAR and LIDAR wind speed measurement techniques under different operating regimes and atmospheric conditions. Results from the measurements will provide definitive data on the performance of the remote wind speed sensing techniques under test on complex terrain typical of many wind farm sites. Preliminary measurements based on data acquired during the initial measurement campaign are presented

  10. Preliminary results of centroiding experiment for the STEP mission

    Science.gov (United States)

    Li, Haitao; Li, Baoquan; Cao, Yang; Chen, Ding; Li, Ligang

    2015-08-01

    Search for Terrestrial Exo-Planet (STEP)[1] was originally proposed in 2013 by the National Space Science Center, Chinese Academy of Sciences, which is currently being under background engineering study phase in China. The STEP mission is a space astrometry telescope working at visible light wavelengths. The STEP aims at the nearby terrestrial planets detection through micro-arcsecond-level astrometry. Determination of the separation between star images on a detector with high precision is very important for astrometric exoplanets detection through the observation of star wobbles due to planets. The requirement of centroiding accuracy for STEP is 1e-5 pixel. A centroiding experiment have been carried out on a metrology testbed in open laboratory. In this paper, we present the preliminary results of determining the separations between star images. Without calibration of pixel positions and intra-pixel response, we have demonstrated that the standard deviation of differential centroiding is below 7.4e-3 pixel by the algorithm of linear corrected photon weighted means(LCPWM)[2,3]. For comparison, the photon weighted means(PWM) and Gauss fitting are also used in the data reduction. These results pave the way for the geometrical calibration and the intra-pixel quantum efficiency(QE) calibration of detector array equipment for micro-pixel accuracy centroiding.

  11. Analytic study of the Tadoma method: background and preliminary results.

    Science.gov (United States)

    Norton, S J; Schultz, M C; Reed, C M; Braida, L D; Durlach, N I; Rabinowitz, W M; Chomsky, C

    1977-09-01

    Certain deaf-blind persons have been taught, through the Tadoma method of speechreading, to use vibrotactile cues from the face and neck to understand speech. This paper reports the results of preliminary tests of the speechreading ability of one adult Tadoma user. The tests were of four major types: (1) discrimination of speech stimuli; (2) recognition of words in isolation and in sentences; (3) interpretation of prosodic and syntactic features in sentences; and (4) comprehension of written (Braille) and oral speech. Words in highly contextual environments were much better perceived than were words in low-context environments. Many of the word errors involved phonemic substitutions which shared articulatory features with the target phonemes, with a higher error rate for vowels than consonants. Relative to performance on word-recognition tests, performance on some of the discrimination tests was worse than expected. Perception of sentences appeared to be mildly sensitive to rate of talking and to speaker differences. Results of the tests on perception of prosodic and syntactic features, while inconclusive, indicate that many of the features tested were not used in interpreting sentences. On an English comprehension test, a higher score was obtained for items administered in Braille than through oral presentation. PMID:904318

  12. Preliminary results of a vapor extraction remediation in low permeability

    International Nuclear Information System (INIS)

    A pressurized underground pipeline ruptured and released approximately 80,000 gallons of JP-4 jet fuel in June, 1988 at Kelly AFB, Texas. The JP-4 spill contaminated unsaturated silt and clay-rich soils. A December 1990 Soil Vapor Extraction (SVE) pilot-scale test at the site showed that SVE was feasible in low permeability soils. The pilot test utilized one vapor extraction well and 12 multi-depth piezometers. Application of 72 inches of water vacuum (iwv) at the extraction well caused pressure drawdowns at piezometers within 20 feet of the extraction well. Pressure data indicated an extraction well radius of influence of 20 feet at a flow rate of 13 standard cubic feet per minute (scfm). The maximum hydrocarbon extraction rate was 286 pounds per day. A full-scale SVE system was designed and installed. Preliminary results indicate an initial hydrocarbon extraction rate of 29 pounds per hour which decreased to approximately 12 pounds per hour after 2 months of operation. Concurrently, the system air flow rate increased from 300 scfm to 500 scfm, and wellhead vacuums dropped from 70 iwv to 23 iwv. In-situ biodegradation of jet fuel is being studied at the site. An in-situ respiration test indicated a biodegradation rate of about 1 milligram of JP-4 removed per kilogram of soil per day

  13. Auroral Spatial Structures Probe Sub-Orbital Mission Preliminary Results

    Science.gov (United States)

    Pratt, J.; Swenson, C.; Martineau, R. J.; Fish, C. S.; Conde, M.; Hampton, D.; Crowley, G.

    2015-12-01

    The NASA Auroral Spatial Structures Probe, 49.002, was launched January 28, 2015 from the Poker Flat Research Range into active aurora over the northern coast of Alaska. The primary objective of this mission was to determine the contribution of small spatial and temporal scale fluctuations of the electric fields to the larger-scale energy deposition processes associated with the aurora. The Auroral Spatial Structures Probe Sub-Orbital Mission consisted of a formation of 7 spacecraft (a main payload with 6 deployable sub-payloads) designed for multiple temporally spaced co-located measurements of electric and magnetic fields in the earth's ionosphere. The mission was able to make observations at a short time scale and small spatial scale convergence that is unobservable by either satellite or ground-based observations. The payloads included magnetometers, electric field double probes, and Langmuir probes as well as a sweeping impedance probe on the main payload. We present here preliminary results from the measurements taken that hint at the underlying spatial structure of the currents and energy deposition in the aurora. The Poynting flux derived from the observations is shown and implications are discussed in terms of the contribution of small spatial scale, rapid temporal scale fluctuations in the currents that deposit energy in the auroral region. Funding provided by NASA Grants NNX11AE23G and NNX13AN20A.

  14. Laboratory study of corrosion of steam generator tubes: Preliminary results

    International Nuclear Information System (INIS)

    The secondary side intergranular attack (IGA) and intergranular stress corrosion cracking (IGSCC) of steam generator tubes often occurs in crevices where impurities are concentrated, due to local elevated temperatures and restricted water flow. From the analysis of tubes pulled from plants, it is believed that alumino-silicates deposits and/or organic species may play a role in the development of IGA in near neutral environments. New observations suggest that similar environments and similar processes are operative inside the corroded grain boundaries. A former study using autoclave tests was mainly devoted to the formation of alumino-silicate deposits similar to those observed in plants. The present work pursued the study of local environments responsible for IGA/SC. It confirms former results on the catalytic decomposition of organic species into acetates and presents more details on the mechanism of formation of alumino-silicate deposits on alloy 600, particularly on the role of iron and, to a lesser extent, nickel cations. It was showed that, under the alumino-silicate deposits and in the presence of some organic species, a non-protective chromium rich layer may grow instead of the usual protective spinel oxide. The mechanism responsible for the formation of this layer is believed to involve interaction between iron and, to a lesser extent, nickel with silica and/or possible interaction between chromium and acetates. Preliminary capsule tests indicate that these conditions may induce the initiation of IGA

  15. Paleomagnetism of subsurface Trenton Group carbonates, southwestern Ontario : preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Garner, N.; Cioppa, M.T. [Windsor Univ., ON (Canada). Dept. of Earth Sciences

    2004-07-01

    The oil and gas industry in Canada and the United States has expressed renewed exploration interest in the Ordovician Trenton and Black River Group carbonates of southwestern Ontario. The hydrocarbon reservoirs in the area are associated with non-porous limestones and isolated areas of dolomitization. Paleomagnetic studies have been conducted on unoriented core from the dolomite-rich Hillman Field to determine if previously characterized dolomitic phases can be distinguished magnetically. More than 200 specimens were collected from a single well, providing a nearly complete section through the Sherman Falls Formation. Preliminary measurements were made using a multi-step alternating field or thermal demagnetization sequence. There were at least two magnetization components in the specimens measured. These included a normal polarity low temperature/low coercivity remanent magnetization, and a reversed polarity characteristic remanent magnetization (ChRM). Results suggest that pyrrhotite and magnetite is present. Although the origin of the high temperature magnetization has not been determined, the generally low temperature magnetization of the ChRM suggests that the magnetization is the Permian Kiaman overprint that is observed in the Appalachian Basin.

  16. Genetic Variation A mong European Lophodermium piceae Populations - Preliminary Results

    Directory of Open Access Journals (Sweden)

    MÜLLER, Michael M.

    2007-01-01

    Full Text Available Lophodermium piceae is a common needle endophyte of Norway spruce (Picea abies. The aim of the present study was to examine the degree of differentiation within and among European populations separated by various distances and geographical obstacles. For this purpose, populations (including > 10 isolates/subpopulation were collected along a north-south transect stretching from the northern timberline in Finnish Lapland to the southern border of the distribution area of Norway spruce in northern Italy. Differentiation between L. piceae populations was determined from DNA sequences of three genetic markers. One of the markers was the internal transcribed spacer (ITS of the ribosomal DNA and the other two (LP1 and LP2 were based on sequence characterized amplified regions (SCAR designed for L. piceae. Preliminary results including sequences of Finnish, Swiss and Italian isolates show low differentiation among populations. According to analysis of molecular variance the among population variation was 1%, 5% and 0% in ITS, LP1 and LP2 markers, respectively.

  17. SWCX Emission from the Helium Focusing Cone - Preliminary Results

    Science.gov (United States)

    Snowden, S. L.; Kuntz, K. D.; Collier, M. R.

    2008-01-01

    Preliminary results from an XMM-Newton campaign to study solar wind charge exchange (SWCX) emission from the heliospheric focusing cone of interstellar helium are presented. The detections of enhanced O VII and O VIII emission from the cone are at the 2(sigma) and 4(sigma) levels. The solar wind charge exchange (SWCX) emission in the heliosphere not associated with distinct objects (e.g., comets and planets including exospheric material in and near Earth s magnetosheath) is proportional to the flux of the solar wind and the space density of neutral material. The neutral material originates in the interstellar medium (ISM) and passes through the solar system due to the relative motion of the Sun and the ISM. The flow of the neutral material through the solar system is strongly perturbed by the Sun both by gravity and by radiation pressure. Because of the relative radiative scattering cross sections and the effect of solar gravitation the density of interstellar hydrogen near the Sun is reduced while interstellar helium is gravitationally focused. This creates a helium focusing cone downstream of the Sun [e.g., 1, and references therein].

  18. Preliminary results of the LAT Calibration Unit beam tests

    International Nuclear Information System (INIS)

    The calibration strategy of the GLAST Large Area Telescope (LAT) combines analysis of cosmic ray data with accelerator particle beams measurements. An advanced Monte Carlo simulation of the LAT, based on the Geant4 package, was set up to reproduce the LAT response to such radiation and to benchmark the event reconstruction and the background rejection strategy before launch and during operation. To validate the LAT simulation, a massive campaign of beam tests was performed between July and November 2006, in parallel with the LAT integration and test, on the LAT Calibration Unit. This is a detector built with spare flight modules and flight-like readout electronics, which was exposed to a large variety of beams, representing the whole spectrum of the signal that will be detected by the LAT, using the CERN and the GSI accelerator facilities. Beams of photons (0 - 2.5 GeV), electrons (1 - 300 GeV), hadrons (π and p, a few GeV - 100 GeV) and ions (C; Xe, 1.5 GeV/n) were shot through the CU to measure the physical processes taking place in the detector and eventually fine-tune their description in the LAT Monte Carlo simulation. This paper describes the motivations and goals of the test runs, the many different experimental setups used, the measured detector performance and preliminary results of the LAT Monte Carlo validation

  19. Preliminary Results of the LAT Calibration Unit Beam Tests

    International Nuclear Information System (INIS)

    The calibration strategy of the GLAST Large Area Telescope (LAT) combines analysis of cosmic ray data with accelerator particle beams measurements. An advanced Monte Carlo simulation of the LAT, based on the Geant4 package, was set up to reproduce the LAT response to such radiation and to benchmark the event reconstruction and the background rejection strategy before launch and during operation. To validate the LAT simulation, a massive campaign of beam tests was performed between July and November 2006, in parallel with the LAT integration and test, on the LAT Calibration Unit. This is a detector built with spare flight modules and flight-like readout electronics, which was exposed to a large variety of beams, representing the whole spectrum of the signal that will be detected by the LAT, using the CERN and the GSI accelerator facilities. Beams of photons (0 - 2.5 GeV), electrons (1 - 300 GeV), hadrons (p and p, a few GeV - 100 GeV) and ions (C Xe, 1.5 GeV/n) were shot through the CU to measure the physical processes taking place in the detector and eventually fine-tune their description in the LAT Monte Carlo simulation. This paper describes the motivations and goals of the test runs, the many different experimental setups used, the measured detector performance and preliminary results of the LAT Monte Carlo validation

  20. Prostate cancer brachytherapy

    International Nuclear Information System (INIS)

    The transperineal brachytherapy with 125I/Pd103 seed implantation guided by transurethral ultrasound must be presented as therapeutical option of low urinary morbidity in patients with localized prostate cancer. The combined clinical staging - including Gleason and initial PSA - must be encouraged, for definition of a group of low risk and indication of exclusive brachytherapy. Random prospective studies are necessary in order to define the best role of brachytherapy, surgery and external beam radiation therapy

  1. Brachytherapy in coronary artery disease

    Energy Technology Data Exchange (ETDEWEB)

    Song, Ho Chun [Chonnam National University Medicine School, Gwangju (Korea, Republic of)

    2006-04-15

    Coronary artery disease is a leading cause of morbidity and mortality across the world. Percutaneous coronary intervention has become the major technique of revascularization. However, restenosis remains a major limitation of this procedure. Recently the need for repeat intervention due to restenosis, the most vexing long-term failure of percutaneous coronary intervention, has been significantly reduced owing to the introduction to two major advances, intracoronary brachytherapy and the drug-eluting stents, intracoronary brachytherapy has been employed in recent years to prevent restenosis lesions with effective results, principally in in-stent restenosis. Restenosis is generally considered as an excessive form of normal wound healing divided up in processes: elastic recoil, neointimal hyperplasia, and negative vascular remodeling. Restenosis has previously been regarded as a proliferative process in which neointimal thickening, mediated by a cascade of inflammatory mediators and other factors, is the key factor. Ionizing radiation has been shown to decrease the proliferative response to injury in animal models of restenosis. Subsequently, several randomized, double-blind trials have demonstrated that intracoronary brachytherapy can reduce the rates to both angiographic restenosis and clinical event rates in patients undergoing percutaneous coronary intervention for in-stent restenosis. Some problems, such as late thrombosis and edge restenosis, have been identified as limiting factors of this technique. Brachytherapy is a promising method of preventing and treating coronary artery restenosis.

  2. Varfarin in the complex treatment of antiphospholipid syndrome: preliminary results

    Directory of Open Access Journals (Sweden)

    T M Reshetnyak

    2003-01-01

    Full Text Available Objective. To assess efficacy and tolerance of varfarin in prophylaxis and therapy of thrombotic complications in patients with antiphospholipid syndrome (APS. Methods. 20 pts with APS (5 male and 15 female received varfarin during a year. 8 of them had primary APS (PAPS and 12 -systemic lupus erythematosus with APS (SLE+APS. 2 other pts (I with SLE+APS and I with PAPS received varfarin during the last 4 years. Nobody from 9 pts with PAPS received corticosteroids (CS. In SLE+APS pts CS dose varied from 4 to 20 mg/day and was not increased during follow up. During the study prothrombine time (PT was examined with thromboplastin ( manufactured by Renam having international sensitivity index 1,2 and international normalization relation (INR. Depending on treatment scheme APS pts were divided into 3 groups. Group 1 included 8 pts with INR<2,0, Group 2-7 with INR >3,0, group 3 - 7 pts with INR<2,0 receiving as additional treatment thrombo ASS 100 mg/day and vasonit from 600 to 1200 mg/day. Results. Two pts with INR = 1,8 had thrombosis recurrence (due to leg thrombophlebitis. There were no recurrences in other groups. 2 from 22 pts had "large" bleedings. "Small" bleedings episodes were noted in 7 from 22 pts. Largely that were subcutaneous bleedings (in 4 pts no more than 5 cm of size. Two pts receiving varfarin with INR 1,8 and 2,4 had renal colic. Conclusion. Our preliminary results prove the necessity of inclusion of varfarin in the treatment of pts with APS and thrombosis but intensive anticoagulant effect is not always desired.

  3. Preliminary results of the XR2-1 experiment

    Energy Technology Data Exchange (ETDEWEB)

    Gauntt, R.O.; Helmick, P.H. [Sandia National Labs., Albuquerque, NM (United States); Humphries, L. [SAIC, Albuquerque, NM (United States)

    1996-03-01

    The XR2-1 (Ex-Reactor) experiment, investigating metallic core-melt relocation in boiling water reactor geometry, was performed on October 12, 1995, following two previous simpler XR1-series tests in August and November of 1993. The XR2-1 test made use of a highly detailed replication of the lower region of the BWR core, including the control blade and channel box structures, fuel rods, fuel canister nosepieces, control blade velocity limiter, and fuel support pieces, in order to investigate a key core melt progression uncertainty for BWR Station Blackout type accidents. The purpose of this experiment program is to examine the behavior of downward-draining molten metallic core materials in a severe reactor accident in a dry BWR core, and to determine conditions under which the molten materials drain out of the core region, or freeze to form blockages in the lower portion of the core. In the event that the draining metallic materials do not form stable blockages in the lower core region, and instead erode the lower core structures such as the lower core plate, then the subsequent core melt progression processes may proceed quite differently than was observed in the TMI-2 accident, with correspondingly different impact on vessel loading and vessel release behavior. The results of the Ex-Reactor tests are preliminary. All of the tests conducted have shown a significant degree of channel box destruction induced by the draining control blade materials. The XR2-1 test further showed that the draining zircaloy melt causes significant disruption of the fuel rod geometry. All of the tests have shown tendencies to form interim blockages as the melts temporarily freeze, but that these blockages re-melt, assisted by eutectic interactions, resulting in the sudden draining of accumulated metallic melt pools.

  4. Langzeitergebnisse bei Aderhautmelanom nach 106Ruthenium-Brachytherapie

    OpenAIRE

    Krause, Nona

    2015-01-01

    Introduction: 106Ruthenium-brachytherapy (106Ru-brachytherapy) is an established therapy for small and medium-sized uveal melanomas. The aim of this study was to examine the long-time results in regard to recurrence rate, complication rate, ocular preservation, metastasis rate and survival with malignant uveal and ciliary body melanoma, as well as relevant prognosis factors, subsequent to 106Ru-brachytherapy. Methodology: In this retrospective study of all cases with uveal or with ciliary ...

  5. AB012. Brachytherapy for localized prostate cancer

    Science.gov (United States)

    Xu, Yong; Yang, Yong

    2016-01-01

    Background To evaluate the security and effect of brachytherapy for localized prostate cancer. Methods Forty five patients with Tl–T2 prostate cancer were treated with real-time transperineal ultrasound-guide 125I seeds prostate implantation. Results The median operation time was 90 min, the median number of I seeds used was 56. The follow up time was 12–48 months, the cases of PSA Brachytherapy for localized prostate cancer is safe and effective.

  6. Therapy of neuroendocrine carcinoma with Y-90 DOTA- preliminary results

    International Nuclear Information System (INIS)

    Full text: Aim: Cell membrane-specific somatostatin receptors are usually expressed by neuroendocrine tumors. Radiolabelled receptor-binding somatostatin analogues target tissues expressing these receptors and can be used for visualization and treatment. After the localization of tumors bearing somatostatin receptors with 111In or 99mTc labeled somatostatin analogues, in the case of high tumor uptake related to non target tissues, different radioisotopes have been used for their treatment. Thus, application of high doses of 111In- DTPA-octreotide had an impact on improvement of the clinical symptoms, without significant reduction of the tumor mass. However, 90Y somatostatin analogues (DOTA TOC, lanreotide) may be more effective for reduction of the tissue of the larger tumors while 177Lu labeled ones may be applied in smaller tumors. Combination of both of them seems to be the most effective therapy, particularly in tumors bearing both small and large lesions. The aim of this work is presentation of the preliminary results of the therapy of NETs with another octreotide analogue, 90Y DOTA TATE, which so far has been proved to have high therapeutic potential when labeled with 177Lu. Patients and methods: We investigated 7 patients with neuroendocrine tumors (two patients had neuroendocrine pancreatic carcinomas with liver metastases (one of them had metastases in peritoneal lymph nodes), one patient with operated (resected) bronchial carcinoid and liver metastases, three patients with neuroendocrine carcinomas of unknown origin and hepatic metastases (one with skeletal metastases) and one with pancreatic gastrinoma without metastases (surgery was impossible to perform). In all of them, together with other laboratory analyses and imaging methods, scintigraphy with somatostatin analogues was performed (in 3 with 111In Octreoscan and in the other 4 with 99mTc HYNIC TOC) and high tumor uptake was observed. The therapy was performed with 2- 4,5 GBq 90Y DOTA TATE per

  7. Preliminary Characterization Results from the DebriSat Project

    Science.gov (United States)

    Rivero, M.; Shiotani, B.; Kleespies, J.; Toledo-Burdett, R.; Moraguez, M.; Carrasquila, M.; Fitz-Coy, N.; Liou, J.-C.; Sorge, M.; Huynh, T.

    2016-01-01

    preliminary results presented. Additionally, lessons learned from the implemented automations and their impacts on the integrity of the results are discussed.

  8. Autonomous Ozone and Aerosol Lidar Platform: Preliminary Results

    Science.gov (United States)

    Strawbridge, K. B.

    2014-12-01

    Environment Canada is developing an autonomous tropospheric ozone and aerosol lidar system for deployment in support of short-term field studies. Tropospheric ozone and aerosols (PM10 and PM2.5) are important atmospheric constituents in low altitude pollution affecting human health and vegetation. Ozone is photo-chemically active with nitrogen oxides and can have a distinct diurnal variability. Aerosols contribute to the radiative budget, are a tracer for pollution transport, undergo complex mixing, and contribute to visibility and cloud formation. This particular instrument will employ two separate lidar transmitter and receiver assemblies. The tropospheric ozone lidar, based on the differential absorption lidar (DIAL) technique, uses the fourth harmonics of a Nd:YAG laser directed into a CO2 Raman cell to produce 276 nm, 287nm and 299 nm (first to third Stokes lines) output wavelengths. The aerosol lidar is based on the 3+2 design using a tripled Nd:YAG to output 355 nm, 532 nm and 1064nm wavelengths. Both lidars will be housed in a modified cargo trailer allowing for easy deployment to remote areas. The unit can be operated and monitored 24 hours a day via an internet link and requires an external power source. Simultaneous ozone and aerosol lidar measurements will provide the vertical context necessary to understand the complex mixing and transformation of pollutants - particularly when deployed near other ground-based in-situ sensors. Preliminary results will be shown from a summer field study at the Centre For Atmospheric Research Experiments (CARE).

  9. COSMIC EVOLUTION OF DUST IN GALAXIES: METHODS AND PRELIMINARY RESULTS

    Energy Technology Data Exchange (ETDEWEB)

    Bekki, Kenji [ICRAR, M468, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009 (Australia)

    2015-02-01

    We investigate the redshift (z) evolution of dust mass and abundance, their dependences on initial conditions of galaxy formation, and physical correlations between dust, gas, and stellar contents at different z based on our original chemodynamical simulations of galaxy formation with dust growth and destruction. In this preliminary investigation, we first determine the reasonable ranges of the most important two parameters for dust evolution, i.e., the timescales of dust growth and destruction, by comparing the observed and simulated dust mass and abundances and molecular hydrogen (H{sub 2}) content of the Galaxy. We then investigate the z-evolution of dust-to-gas ratios (D), H{sub 2} gas fraction (f{sub H{sub 2}}), and gas-phase chemical abundances (e.g., A {sub O} = 12 + log (O/H)) in the simulated disk and dwarf galaxies. The principal results are as follows. Both D and f{sub H{sub 2}} can rapidly increase during the early dissipative formation of galactic disks (z ∼ 2-3), and the z-evolution of these depends on initial mass densities, spin parameters, and masses of galaxies. The observed A {sub O}-D relation can be qualitatively reproduced, but the simulated dispersion of D at a given A {sub O} is smaller. The simulated galaxies with larger total dust masses show larger H{sub 2} and stellar masses and higher f{sub H{sub 2}}. Disk galaxies show negative radial gradients of D and the gradients are steeper for more massive galaxies. The observed evolution of dust masses and dust-to-stellar-mass ratios between z = 0 and 0.4 cannot be reproduced so well by the simulated disks. Very extended dusty gaseous halos can be formed during hierarchical buildup of disk galaxies. Dust-to-metal ratios (i.e., dust-depletion levels) are different within a single galaxy and between different galaxies at different z.

  10. Intraspecific variability of European larch for wood properties: Preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Paques, L.E.; Rozenberg, P. [Institut National de Recherches Agronomiques (INRA), 45 - Olivet (France). Station d`Amelioration des Arbres Forestiers

    1995-12-31

    Wood properties of several natural populations of European larch (Larix decidua Mill) were determined from samples collected in one replicate of the II. International IUFRO provenance experiment, planted in Brittany in 1959. According to provenances, proportion of heartwood ranges from 35 to 58% of basal area, basic density from 442 to 505 g/dm{sup 3} and Young modulus of elasticity from 8474 to 14522 MPa. Positive correlations between girth and heartwood proportion and between wood density and modulus of elasticity but negative correlations between ring width and both density and MOE have been found both at the individual and at the population levels. Variability between and within provenances is high for two major traits (proportion of heartwood and Young modulus of elasticity) for which a SW - NE gradient is shown. For wood density parameters including pilodyn, a greater homogeneity is observed. Besides a now largely recognized superiority for growth traits, Central European populations from the Sudetan Mountains and Central Poland would also produce wood with better properties. On the reverse, Alpine populations from the French Alps growing at low elevations have a slower growth, a denser wood with less heartwood and less strength. Used as a control, the hybrid larch origin (Larix x eurolepis) represents the best compromise for wood properties with the highest strength but an average wood density and one of the highest proportion of heartwood. These preliminary results must be confirmed from a larger set of provenances and completed with other major wood properties such as durability and shrinkage. 17 refs, 2 figs, 6 tabs

  11. Magnetic Resonance Elastography of Liver Tumors- Preliminary Results

    Science.gov (United States)

    Venkatesh, Sudhakar K; Yin, Meng; Glockner, James F; Takahashi, Naoki; Araoz, Philip A; Talwalkar, Jayant A; Ehman, Richard L

    2010-01-01

    Aim To evaluate the potential value of magnetic resonance elastography (MRE) for characterizing solid liver tumors. Materials and Methods Forty-four liver tumors (metastases-14, hepatocellular carcinoma- 12, hemangioma-9, cholangiocarcinoma-5, focal nodular hyperplasia-3, and hepatic adenoma-1) were evaluated with MRE. MRE was performed on a 1.5 T scanner with a modified phase-contrast, gradient echo sequence to collect axial wave images sensitized along the through-plane motion direction. The tumors were identified in T2-, T1-weighted and gadolinium enhanced T1-weighted images and the MRE images were obtained through the tumor. A stiffness map (elastogram) was generated by an automated process using an inversion algorithm. The mean shear stiffness of the tumor was calculated using a manually specified region of interest placed over the tumor in the stiffness map. The stiffness value of non-tumor bearing hepatic parenchyma was also calculated. Statistical analysis was performed on the stiffness values for differentiation between normal liver, fibrotic liver, benign tumors and malignant tumors. Results Malignant liver tumors had significantly higher mean shear stiffness than benign tumors, fibrotic liver and normal liver (10.1kPa vs. 2.7kpa (p<0.001), vs. 5.9kPa (p<0.001) and vs. 2.3kPa (p<0.001) respectively). Fibrotic livers had stiffness values overlapping both the benign and malignant tumors. Cut-off values of 5kPa accurately differentiate malignant tumors from benign tumors and normal liver parenchyma in this preliminary investigation. Conclusions MR elastography is a promising, non-invasive technique for assessing solid liver tumors. MRE may provide new, quantitative tissue characterization parameters for differentiating benign and malignant liver tumors. PMID:18492904

  12. Treatment of Locally Advanced Vaginal Cancer With Radiochemotherapy and Magnetic Resonance Image-Guided Adaptive Brachytherapy: Dose–Volume Parameters and First Clinical Results

    International Nuclear Information System (INIS)

    Purpose: To investigate the clinical feasibility of magnetic resonance image-guided adaptive brachytherapy (IGABT) for patients with locally advanced vaginal cancer and to report treatment outcomes. Methods and Materials: Thirteen patients with vaginal cancer were treated with external beam radiotherapy (45–50.4 Gy) plus IGABT with or without chemotherapy. Distribution of International Federation of Gynecology and Obstetrics stages among patients were as follows: 4 patients had Stage II cancer, 5 patients had Stage III cancer, and 4 patients had Stage IV cancer. The concept of IGABT as developed for cervix cancer was transferred and adapted for vaginal cancer, with corresponding treatment planning and reporting. Doses were converted to the equivalent dose in 2 Gy, applying the linear quadratic model (α/β = 10 Gy for tumor; α/β = 3 for organs at risk). Endpoints studied were gross tumor volume (GTV), dose-volume parameters for high-risk clinical target volume (HRCTV), and organs at risk, local control (LC), adverse side effects, and survival. Results: The mean GTV (± 1 standard deviation) at diagnosis was 45.3 (±30) cm3, and the mean GTV at brachytherapy was 10 (±14) cm3. The mean D90 for the HRCTV was 86 (±13) Gy. The mean D2cc for bladder, urethra, rectum, and sigmoid colon were 80 (±20) Gy, 76 (±16) Gy, 70 (±9) Gy, and 60 (±9) Gy, respectively. After a median follow-up of 43 months (range, 19–87 months), one local recurrence and two distant metastases cases were observed. Actuarial LC and overall survival rates at 3 years were 92% and 85%. One patient with Stage IVA and 1 patient with Stage III disease experienced fistulas (one vesicovaginal, one rectovaginal), and 1 patient developed periurethral necrosis. Conclusions: The concept of IGABT, originally developed for treating cervix cancer, appears to be applicable to vaginal cancer treatment with only minor adaptations. Dose-volume parameters for HRCTV and organs at risk are in a comparable range

  13. Treatment of Locally Advanced Vaginal Cancer With Radiochemotherapy and Magnetic Resonance Image-Guided Adaptive Brachytherapy: Dose-Volume Parameters and First Clinical Results

    Energy Technology Data Exchange (ETDEWEB)

    Dimopoulos, Johannes C.A. [Department of Radiation Oncology, Metropolitan Hospital, Athens (Greece); Schmid, Maximilian P., E-mail: maximilian.schmid@akhwien.at [Department of Radiotherapy, Medical University of Vienna, Vienna (Austria); Fidarova, Elena; Berger, Daniel; Kirisits, Christian; Poetter, Richard [Department of Radiotherapy, Medical University of Vienna, Vienna (Austria)

    2012-04-01

    Purpose: To investigate the clinical feasibility of magnetic resonance image-guided adaptive brachytherapy (IGABT) for patients with locally advanced vaginal cancer and to report treatment outcomes. Methods and Materials: Thirteen patients with vaginal cancer were treated with external beam radiotherapy (45-50.4 Gy) plus IGABT with or without chemotherapy. Distribution of International Federation of Gynecology and Obstetrics stages among patients were as follows: 4 patients had Stage II cancer, 5 patients had Stage III cancer, and 4 patients had Stage IV cancer. The concept of IGABT as developed for cervix cancer was transferred and adapted for vaginal cancer, with corresponding treatment planning and reporting. Doses were converted to the equivalent dose in 2 Gy, applying the linear quadratic model ({alpha}/{beta} = 10 Gy for tumor; {alpha}/{beta} = 3 for organs at risk). Endpoints studied were gross tumor volume (GTV), dose-volume parameters for high-risk clinical target volume (HRCTV), and organs at risk, local control (LC), adverse side effects, and survival. Results: The mean GTV ({+-} 1 standard deviation) at diagnosis was 45.3 ({+-}30) cm{sup 3}, and the mean GTV at brachytherapy was 10 ({+-}14) cm{sup 3}. The mean D90 for the HRCTV was 86 ({+-}13) Gy. The mean D2cc for bladder, urethra, rectum, and sigmoid colon were 80 ({+-}20) Gy, 76 ({+-}16) Gy, 70 ({+-}9) Gy, and 60 ({+-}9) Gy, respectively. After a median follow-up of 43 months (range, 19-87 months), one local recurrence and two distant metastases cases were observed. Actuarial LC and overall survival rates at 3 years were 92% and 85%. One patient with Stage IVA and 1 patient with Stage III disease experienced fistulas (one vesicovaginal, one rectovaginal), and 1 patient developed periurethral necrosis. Conclusions: The concept of IGABT, originally developed for treating cervix cancer, appears to be applicable to vaginal cancer treatment with only minor adaptations. Dose-volume parameters for HRCTV and

  14. Mycodiversity in marine sediments contaminated by heavy metals: preliminary results

    Science.gov (United States)

    Zotti, Mirca; Carbone, Cristina; Cecchi, Grazia; Consani, Sirio; Cutroneo, Laura; Di Piazza, Simone; Gabutto, Giacomo; Greco, Giuseppe; Vagge, Greta; Capello, Marco

    2016-04-01

    .6 CFU per gram of sediments. The maximum value of 11 CFU g-1 has been recorded in two stations (off the Sestri Levante Tombolo), while the minimum value has been recorded closer to the coast. As concern qualitative results, the most recurrent genera are Aspergillus and Penicillium. These data confirm the occurrence of a mycobiota in these heavy metal contaminated sediments. Our preliminary results are a first contribution to the knowledge of presence of microfungi in marine sediments, and propel us to increase our research in order to find out new organisms for bioremediation purpose.

  15. Anisotropy of Pore Structure and Permeability in Granite: Preliminary Results

    Science.gov (United States)

    Onishi, C. T.; Shimizu, I.; Mizoguchi, K.; Uehara, S.; Shimamoto, T.

    2001-12-01

    of 25- 200 MPa, with pore pressure kept around 20 MPa. Preliminary results indicate relatively high permeability for undeformed biotite granite, about 10-16m2 at the initial confining pressure (Pc=30MPa), and with a gradual decrease to 10-17m2 at the highest Pc(=198MPa). The fractured sample with cataclastic seams has lower permeability (in the order of 10-17 to 10-18m2) possibly due to crack sealing by hydrothermal activities.

  16. Dynamics of the Caspian Sea: Preliminary results of isotope studies

    International Nuclear Information System (INIS)

    The water level of the Caspian Sea, the world's largest inland water body, rose by approximately 2 m within the last 20 years. To explore the potential of isotope techniques for studying the water balance and dynamics of the Caspian Sea and aspects related to the recent sea level rise, two research-training cruises were carried out in September 1995 and 1996 within the framework of an IAEA technical co-operation project. The paper presents a preliminary evaluation of the results obtained so far. By correlating sea level fluctuations and freshwater inflow variations observed in previous studies, it has been found that changes of the sea level are caused by changes in the water budget, mainly in the river input. The water of the Caspian Sea is enriched in oxygen-18 with respect to the total inflow (rivers plus precipitation) by about 9 per mille. The vertical distribution of δ18O observed in the southern and central basins of the Caspian Sea indicates that the main water body of the sea (between 200 m and 800 m depth) is enriched in oxygen-18 with respect to the surface layer by approximately 0.3 per mille. This enrichment suggests that water at depth most probably represents the previous low level stand of the Caspian Sea (1950-1977) and that the total inflow exceeded the evaporation by about 10% during the recent sea level rise. Vertical temperature and salinity gradients observed during the 1995 and 1996 expeditions suggest that deep water exchange in the central and southern basins of the Caspian Sea cannot be triggered by cooling of surface water alone but also requires an increase of salinity. The presence of bomb tritium and tritiogenic helium-3 in the deep water of the central and southern basins points to rather intense vertical water exchange in both basins. The water ages calculated from tritium and helium-3 increase from shallow to deep water in both basins; near the bottom, a maximum model age of some 20 to 25 years was. (author) obtained

  17. Brachytherapy in the treatment of genitourinary rhabdomyosarcoma in children

    International Nuclear Information System (INIS)

    Brachytherapy has been widely used at the Institut Gustave Roussy since 1972 in pediatric oncology. In genitourinary rhabdomyosarcoma, because of its ballistic and physical characteristics, it represents the optimal treatment whenever irradiation is required and brachytherapy feasible. Between 1976 and 1998, 23 children with bladder or prostate rhabdomyosarcoma were treated with a protocol including brachytherapy, with five of them treated with a salvage brachytherapy. All but one brachytherapy was performed during the surgery. Among the 18 brachy-therapies performed as a first-line treatment, eight presented a tumoral evolution: five presented a local evolution, one a local and nodal evolution and two a nodal evolution. Brachytherapy allowed a conservative treatment among ten out of 11 children alive with no evidence of disease. Among the five patients with salvage brachytherapy, two presented a second recurrence. Sequelae were minimal, consisting of one grade I rectitis and one asymptomatic vesical and ureteral reflux. These results are consistent with the published data using more radical treatment. Brachytherapy can represent an alternative to radical surgery, when indications are clearly defined in bladder or prostate rhabdomyosarcoma. This type of treatment can be performed only integrated with other treatments, more particularly with surgery. This approach requires a close cooperation between the different specialists: pediatricians, surgeons and brachy-therapists. (authors)

  18. Brachytherapy: Physical and clinical aspects

    International Nuclear Information System (INIS)

    take advantage of published results. The use of uniform models and methods in brachytherapy treatments simplifies comparison of treatment results. A typical treatment in which a model may be used is, for example, the treatment of cancer of the cervix, in which the dose is given to a specific point A, or low dose rate (LDR) treatments of head and neck cancers using 192Ir wires. In this latter case the Paris model provides suitable guidelines for calculation of the treatment dose and time. For treatments in which dose optimization techniques are used, the treatment times depend on how the sources are positioned relative to the dose calculation points and on the source strength. In situations in which the system to be used is not obvious, the scientific literature should be consulted in order to take full advantage of already existing experience. With the use of a specific method for the brachytherapy treatment and a model for the dose distribution calculation, comparison of results is simplified. The use of a well established dosimetric system for the treatment of cancer gives a common point for such comparisons. However, the use of a model alone is not sufficient to validate results; it is necessary to have a reliable method for determination of the source strength in order for the dose calculation to be accurate. This means that it is necessary for brachytherapy sources to be calibrated, with the calibration traceable to a national or international standards laboratory. The important aspects of any brachytherapy treatment are: Use of a suitable dosimetric model for the treatment time and dose calculation; Use of calibrated sources. These are by no means all the necessary components. A treatment does not reach its goals if the source misses its aimed positions by a large margin; that is, if there are severe geographical misses in placing the sources relative to their intended positions. Owing to the steep dose gradient that characterizes brachytherapy, such geometrical

  19. Preliminary Results from SCEC Earthquake Simulator Comparison Project

    Science.gov (United States)

    Tullis, T. E.; Barall, M.; Richards-Dinger, K. B.; Ward, S. N.; Heien, E.; Zielke, O.; Pollitz, F. F.; Dieterich, J. H.; Rundle, J. B.; Yikilmaz, M. B.; Turcotte, D. L.; Kellogg, L. H.; Field, E. H.

    2010-12-01

    realistic fault geometies and slip rates taken from California, excluding the Cascadia subduction zone. In order to make as close comparisons between the simulators as possible we have developed shared data formats for both input and output and a growing set of tools that can be used to make statistical comparisons between the simulator outputs. To date all five simulators have run a Northern California fault model and are in various stages of working on an All California fault model. The plan in the near future is to run them on the UCERF2 fault model. Initial comparisons show significant differences among the simulators and some differences from observed earthquake statistics. However, it is too early in the process to infer too much from these preliminary results. For example, the differences in how each simulator treats fault friction means that they may each need to use values for the assumed stress drops that are better tuned to their approach than are the common values used in the first comparison.

  20. Treatment results of combined interstitial high-dose-rate brachytherapy and ablative surgery for advanced-stage oral and oropharyngeal squamous cell carcinoma

    International Nuclear Information System (INIS)

    Oral and oropharyngeal squamous cell carcinoma in 38 patients were treated over a period of 7 years (1988-1994) by HDR interstitial brachytherapy using Gammamed trademark 12i equipment. Pretreatment of patients in terms of irradiation and surgery differed (33 irradiated with a total dose between 60.0 and 75.6 Gy, including 8 patients with additional surgery; 1 patient with surgery alone, and 4 patients without any pretreatment). Indications for interstitial brachytherapy differed according to individual responses to treatment and medical histories. Interstitial brachytherapy was successful in the majority of patients, i.e. complete remission: 12, partial remission: 19, no change: 2, progression: 5. Local control and overall survival including patients with surgical treatment was 59% and 81% at 6 months and 47% and 49% after 12 months, respectively. (orig.)

  1. Preliminary results of the PREFER FP7 Project

    Science.gov (United States)

    Fusilli, Lorenzo; Laneve, Giovanni; De Bonis, Roberto; Sebastian, Ana; Ferrucci, Fabrizio; Oliveira, Sandra

    2014-05-01

    The need to improve the information and intelligence support for forest fire prevention is widely recognized. Fire prevention is still the most cost-effective strategy when compared to firefighting and extinguishing that are costly, local, and triggered only in response to already ongoing crises. PREFER project, funded under the EU FP7 (G.A. 312931), intends to contribute at responding to such a pragmatic need of southern Europe's forests by: providing timely information products based on the exploitation of all available spacecraft sensors, offering a portfolio of products focused on pre- and post-crisis forest fire emergency, suitable for the users in the different countries of the European Mediterranean area. The PREFER Service portfolio consists of two main services: 1. Information Support to Fire Preparedness/Prevention Phase" (ISP) Service 2. Information Support to Fire Recovery/Reconstruction Phase" (ISR) Service This service is already at an advanced stage having completed the first year of activity. During this time several products have been consolidated: seasonal fuel maps; daily and seasonal fire hazard maps; seasonal risk maps; prescribed fire maps. This paper aims at presenting the preliminary results of the research activity carried out in the framework of the PREFER project, focusing, in particular, on these recalled above. As for Fire Risk and Hazard assessment, many indexes have been developed in the last years. Hardly any of them uses data derived from satellite images. The FPI index is an exception to this rule which, in addition, makes use of meteorological data. In spite of being a very complete index, the FPI still allows room for improvement which justify the interest of PREFER in it. PREFER's innovative approach to FPI will allow taking into account the effect of solar illumination conditions in determining the humidity present in the dead vegetation, and therefore its proneness to burn. PREFER innovation also focus in allowing the index to

  2. Metabolic syndrome in rheumatoid arthritis: role of adiponectin (preliminary results

    Directory of Open Access Journals (Sweden)

    Yulia Nikolaevna Gorbunova

    2013-01-01

    were encountered with the same frequency in early- and end-stage RA. The early RA group showed a correlation between SDAI (r = -0.34, body mass index (r = -0.41, high-density lipoprotein cholesterol (r = 0.33, erythrocyte sedimentation rate (r =-0.35, and adiponectin. The >2-year RA group displayed no relationship between adipokins, activity markers, and metabolic disturbances. Conclusion. The preliminary results suggest the high rate of MS in patients with a high level of early RA disease activity untreated with disease-modifying antirheumatic drugs, thus determining the high risk of CVEs just at disease onset. The role of adiponectin in the development of MS, CVEs in rheumatic diseases remains to be solved, which is the subject of further investigations. It is possible that normalization of adiponectin concentrations may promote reductions in the incidence of CVD, mortality rates due to atherosclerosis-induced CVEs, and the prevalence of MS and insulin resistance.

  3. Rectal function following prostate brachytherapy

    International Nuclear Information System (INIS)

    Purpose: Quality of life following therapeutic intervention for carcinoma of the prostate gland has not been well documented. In particular, a paucity of data has been published regarding bowel function following prostate brachytherapy. This study evaluated late bowel function in 209 consecutive prostate brachytherapy patients via a one-time questionnaire administered 16-55 months postimplant. Materials and Methods: Two hundred nineteen consecutive patients underwent permanent prostate brachytherapy from April 1995 through February 1998 using either 125I or 103Pd for clinical T1c-T3a carcinoma of the prostate gland. Of the 219 patients, 7 had expired. Of the remaining 212 patients (median follow-up, 28 months), each patient was mailed a self-administered questionnaire (10 questions) with a prestamped return envelope; 209 (98.6%) surveys were returned. Clinical parameters evaluated for bowel dysfunction included patient age, diabetes, hypertension, history of tobacco consumption, clinical T-stage, elapsed time since implant, and prostate ultrasound volume. Treatment parameters included utilization of neoadjuvant hormonal manipulation, utilization of moderate dose external beam radiation therapy prior to implantation, choice of isotope (125I vs. 103Pd), rectal dose (average, median and maximum doses), total implanted seed strength, values of the minimum dose received by 90% of the prostate gland (D90), and the percent prostate volume receiving 100%, 150%, and 200% of the prescribed minimum peripheral dose (V100, V150 and V200, respectively). Because detailed baseline bowel function was not available for these patients, a cross-sectional survey was performed in which 30 newly diagnosed prostate cancer patients of comparable demographics served as controls. Results: The total rectal function scores for the brachytherapy and control patients were 4.3 and 1.6, respectively, out of a total 27 points (p 103Pd resulted in lower radiation doses to the rectum, the choice of

  4. Optical scattering (TAOS) by tire debris particles: preliminary results

    Science.gov (United States)

    Crosta, Giovanni F.; Camatini, Marina C.; Zomer, Simeone; Holler, Stephen; Pan, Yongle; Bhaskara, Praveena; Muangchareon, Pongphisanu; Sung, Changmo; Cencetti, Simone; Regazzoni, Claudia

    2001-03-01

    Tire debris particles from low severity laboratory wear tests have been investigated by the TAOS optical scattering facility at Yale University. The incident wavelength is 532 nm. After the TAOS event some particle samples have been imaged by a scanning electron microscope and microanalyzed. The TAOS intensity patterns recorded within a solid angle in the backward sector have been processed by cluster analysis and compared with the patterns computed by a T-matrix code. Preliminary agreement has been found between TAOS data and the particle models (size, shape, refractive index). The purpose of the investigation is to obtain signatures of the material, based on its TAOS pattern.

  5. 78 FR 77651 - Seamless Refined Copper Pipe and Tube From Mexico: Preliminary Results of Antidumping Duty...

    Science.gov (United States)

    2013-12-24

    ... Refined Copper Pipe and Tube From Mexico: Final Results of Antidumping Duty New Shipper Review, 77 FR... International Trade Administration Seamless Refined Copper Pipe and Tube From Mexico: Preliminary Results of... are invited to comment on these preliminary results. \\1\\ See Seamless Refined Copper Pipe and...

  6. Feasibility and early results of interstitial intensity-modulated HDR/PDR brachytherapy (IMBT) with/without complementary external-beam radiotherapy and extended surgery in recurrent pelvic colorectal cancer

    International Nuclear Information System (INIS)

    Background: A new multimodality treatment concept consisting of extended resection and postoperative fractionated intensity-modulated interstitial brachytherapy (IMBT) was introduced for pelvic recurrence of colorectal carcinoma. Patients and Methods: 46 patients received extended resection and single plastic tubes were sutured directly onto the tumor bed. IMBT was started within 2 weeks postoperatively with a median dose of 24.5 Gy (5-35 Gy). Patients were treated either with high-dose-rate brachytherapy (HDR; n=23) or with pulsed-dose-rate brachytherapy (PDR; n=23). 25 patients received complementary 45-Gy external-beam irradiation (EBRT) to the pelvic region after explanting the plastic tubes. Results: Median follow-up was 20.6 months (7-107 months) and mean patient survival 25.7±25.8 months (median 17, range 1-107 months). After 5 years overall survival, disease-free survival and local control rate were 23%, 20% and 33%, significantly influenced by the resectional state. There was a trend in favor of PDR compared to HDR, which reached statistical significance in patients who had not received additional EBRT. Conclusion: The combination of extended surgery and postoperative interstitial IMBT is feasible and offers effective interdisciplinary treatment of recurrent colorectal cancer. In this small and inhomogeneous cohort of patients PDR seems to be more effective than HDR, particularly when application of complementary EBRT is not possible. None of the patients who required resection of distant metastasis survived >2 years in this study. (orig.)

  7. Computer-aided hepatic tumour ablation requirements and preliminary results

    CERN Document Server

    Voirin, D; Amavizca, M; Letoublon, C; Troccaz, J; Voirin, David; Payan, Yohan; Amavizca, Miriam; Letoublon, Christian; Troccaz, Jocelyne

    2002-01-01

    Surgical resection of hepatic tumours is not always possible, since it depends on different factors, among which their location inside the liver functional segments. Alternative techniques consist in local use of chemical or physical agents to destroy the tumour. Radio frequency and cryosurgical ablations are examples of such alternative techniques that may be performed percutaneously. This requires a precise localisation of the tumour placement during ablation. Computer-assisted surgery tools may be used in conjunction with these new ablation techniques to improve the therapeutic efficiency, whilst they benefit from minimal invasiveness. This paper introduces the principles of a system for computer-assisted hepatic tumour ablation and describes preliminary experiments focusing on data registration evaluation. To keep close to conventional protocols, we consider registration of pre-operative CT or MRI data to intra-operative echographic data.

  8. Preliminary Results on Lunar Interior Properties from the GRAIL Mission

    Science.gov (United States)

    Williams, James G.; Konopliv, Alexander S.; Asmar, Sami W.; Lemoine, H. Jay; Melosh, H. Jay; Neumann, Gregory A.; Phillips, Roger J.; Smith, David E.; Solomon, Sean C.; Watkins, Michael M.; Wieczorek, Mark A.; Zuber, Maria T.; Andrews-Hanna, Jeffrey C.; Head, James W.; Kiefer, Walter S.; Matsuyama, Isamu; McGovern, Patrick J.; Nimmo, Francis; Weber, Renee C.; Boggs, D. H.; Goossens, Sander J.; Kruizinga, Gerhard L.; Mazarico, Erwan; Park, Ryan S.; Yuan, Dah-Ning

    2013-01-01

    The Gravity Recovery and Interior Laboratory (GRAIL) mission has provided lunar gravity with unprecedented accuracy and resolution. GRAIL has produced a high-resolution map of the lunar gravity field while also determining tidal response. We present the latest gravity field solution and its preliminary implications for the Moon's interior structure, exploring properties such as the mean density, moment of inertia of the solid Moon, and tidal potential Love number k2. Lunar structure includes a thin crust, a deep mantle, a fluid core, and a suspected solid inner core. An accurate Love number mainly improves knowledge of the fluid core and deep mantle. In the future GRAIL will search for evidence of tidal dissipation and a solid inner core.

  9. Long-term biochemical results after high-dose-rate intensity modulated brachytherapy with external beam radiotherapy for high risk prostate cancer

    International Nuclear Information System (INIS)

    Biochemical control from series in which radical prostatectomy is performed for patients with unfavorable prostate cancer and/or low dose external beam radiation therapy are given remains suboptimal. The treatment regimen of HDR brachytherapy and external beam radiotherapy is a safe and very effective treatment for patients with high risk localized prostate cancer with excellent biochemical control and low toxicity

  10. Single-Fraction High-Dose-Rate Brachytherapy and Hypofractionated External Beam Radiation Therapy in the Treatment of Intermediate-Risk Prostate Cancer – Long Term Results

    International Nuclear Information System (INIS)

    Purpose: We present the long-term results of a cohort of patients with intermediate-risk prostate cancer (PC) treated with single-fraction high-dose-rate brachytherapy (HDRB) combined with hypofractionated external beam radiation therapy (HypoRT). Methods and Materials: Patients were treated exclusively with HDRB and HypoRT. HDRB delivered a dose of 10 Gy to the prostate surface and HypoRT consisted of 50 Gy delivered in 20 daily fractions. The first 121 consecutive patients with a minimum of 2 years posttreatment follow-up were assessed for toxicity and disease control. Results: The median follow-up was 65.2 months. No acute Grade III or higher toxicity was seen. Late Grade II gastrointestinal toxicity was seen in 9 patients (7.4%) and Grade III in 2 (1.6%). Late Grade III genitourinary toxicity was seen in 2 patients (1.6%). After a 24-month follow-up, a rebiopsy was offered to the first 58 consecutively treated patients, and 44 patients agreed with the procedure. Negative biopsies were found in 40 patients (91%). The 5-year biochemical relapse-free survival rate was 90.7% (95% CI, 84.5–96.9%), with 13 patients presenting biochemical failure. Among them, 9 were diagnosed with distant metastasis. Prostate cancer–specific and overall survival rates at 5 years were 100% and 98.8% (95% CI, 96.4–100%), respectively. Conclusion: The combination of HDRB and HypoRT is well tolerated, with acceptable toxicity rates. Furthermore, results from rebiopsies revealed an encouraging rate of local control. These results confirm that the use of conformal RT techniques, adapted to specific biological tumor characteristics, have the potential to improve the therapeutic ratio in intermediate-risk PC patients.

  11. 78 FR 34649 - Aluminum Extrusions From the People's Republic of China: Preliminary Results of Countervailing...

    Science.gov (United States)

    2013-06-10

    ..., 76 FR 30653 (May 26, 2011) (Order). \\3\\ See ``Decision Memorandum for Preliminary Results of the... International Trade Administration Aluminum Extrusions From the People's Republic of China: Preliminary Results...) is conducting an administrative review of the countervailing duty (CVD) order on aluminum...

  12. 75 FR 48310 - Purified Carboxymethylcellulose From the Netherlands; Preliminary Results of Antidumping Duty...

    Science.gov (United States)

    2010-08-10

    ...: Purified Carboxymethylcellulose from the Netherlands, 70 FR 28275 (May 17, 2005). We have not completed a... Netherlands; Preliminary Results of Antidumping Duty Administrative Review, 74 FR 24823 (May 26, 2009) at... Carboxymethylcellulose From the Netherlands; Preliminary Results of Antidumping Duty Administrative Review, 74 FR...

  13. The role of high-dose-rate brachytherapy boost in breast-conserving therapy: Long-term results of the Hungarian National Institute of Oncology

    International Nuclear Information System (INIS)

    Aim: To report the long-term results of high-dose-rate (HDR) brachytherapy (BT) boost for breast cancer patients treated with conservative surgery and radiotherapy. Materials and methods: Between 1995 and 2007, 100 early-stage breast cancer patients received an HDR BT boost after conservative surgery and whole breast irradiation. Ten patients (10%) received a single-fraction HDR boost of 8 - 10.35 Gy using rigid needles, while 90 (90%) were treated with a fractionated multi-catheter HDR BT boost. The latter consisted of 3 x 4 Gy (n = 19), 4.75 Gy (n = 70), and 2 x 6.4 Gy (n = 1). Breast cancer related events, cosmetic results and side effects were assessed. Results: At a median follow-up time of 94 months (range: 8 - 152) only 7 (7%) ipsilateral breast failures were observed for a 5- and 8-year actuarial rate of 4.5 and 7.0%, respectively. The 8-year disease-free, cancer-specific, and overall survival was 76.1, 82.8, and 80.4%, respectively. Cosmetic outcome was rated excellent in 17%, good in 39%, fair in 33%, and poor in 11%. Data on late radiation side effects were available for 91 patients (91%). Grade 3 fibrosis and grade 3 telangiectasia occurred in 6 (6.6%) and 2 (2.2%) patients, respectively. In univariate analysis only positive margin status had a significant negative effect on local control. Conclusions: HDR BT boost using multi-catheter implants produce excellent long-term local tumour control with acceptable cosmetic outcome and low rate of grade 3 late radiation side effects. (authors)

  14. Patterns of toxicity following high-dose-rate brachytherapy boost for prostate cancer: Mature prospective phase I/II study results

    International Nuclear Information System (INIS)

    Background: To examine the long-term morbidity of high dose rate brachytherapy boost (HDRBB) in prostate cancer. Patients and methods: A phase I/II HDRBB dose escalation protocol recruited 108 men up to November 1999. Treatment combined 46 Gy external beam radiation to the prostate with four fractions of HDR totalling 16 or 20 Gy. Morbidity data were collected prospectively regarding urological, bowel and erectile dysfunction (ED) symptoms using a validated clinician completed instrument. Actuarial incidence and prevalence of symptoms were estimated; the latter to account for potential recovery. Results: The median follow-up was 78 months, with 880 questionnaires completed. The respective actuarial cumulative incidence and point prevalence rates of any grade 2 or higher symptom score at 5 years were 24.9% (95% confidence intervals [CI] 16.8-33.5%) and 7.7% (95% CI 1.8-14.5%) for urinary toxicity; and 11.3% (95% CI 5.6-17.1%) and 3.0% (0-7.6%) for rectal toxicity, meaning that most symptom sub-domains showed substantial recovery with time. Corresponding erectile function toxicity figures for the subgroup of men (n = 53) with normal erectile function prior to treatment and no androgen deprivation therapy were 77.0% (95% CI 64.9-88.1%) and 45.3% (95% CI 27.2-64.6%). Some late toxicity profiles developed after twelve months, typically with low grade bowel and urinary urgency. These peaked at 12-24 months and stayed relatively stable subsequently. Paradoxically, grade 1 or more nocturia symptoms settle with time, despite the accumulation of grade 2 or more toxicity beyond 24 months. Conclusions: HDRBB as a means of dose escalation in prostate cancer is associated with low and relatively stable rates of long-term bowel and urinary morbidity, and compares favourably with external beam results. Actuarial incidence methods overstate the burden of toxicity with substantial recovery noted in most domains

  15. Partial breast irradiation as sole therapy for low risk breast carcinoma: Early toxicity, cosmesis and quality of life results of a MammoSite brachytherapy phase II study

    International Nuclear Information System (INIS)

    Purpose: The MammoSite is a device that was developed with the goal of making breast-conserving surgery (BCT) more widely available. Our objective was to evaluate the MammoSite device performances after an open cavity placement procedure and quality of life in highly selected patients with early-stage breast cancer. Methods and materials: From March 2003 to March 2005, 43 patients with T1 breast cancer were enrolled in a phase II study. The median age was 72 years. Twenty-five (58%) patients were treated with high-dose rate brachytherapy using the MammoSite applicator to deliver 34 Gy in 10 fractions. The main disqualifying factor was pathologic sentinel node involvement (10/43; 23%). There were no device malfunctions, migration or rupture of the balloon. Results: After a median follow-up of 13 months, there were no local recurrences and one contralateral lobular carcinoma. Seventeen (68%), 13 (52%), 8 (32%), 5 (20%) and 2 (8%) patients had erythema, seroma, inflammation, hematoma and sever infection, respectively. Only 2 patients developed telangiectasia. At 1 year the rate of 'good to excellent' cosmetic results was 84%. Significant changes in QoL were observed for emotional and social well-being between 3 and 12 months. At 24 months, only emotional well-being subscore changes were statistically significant (p = 0.015). Conclusions: Our data in patients older than 60 years support the previously published data. Histologic features were the main disqualifying criteria. With higher skin spacing levels we observed very low incidence of telangiectasia. QoL evaluation indicates that baseline scores were satisfactory. Changes concerned emotional and social well-being

  16. A Prospective Cohort Study to Compare Treatment Results Between 2 Fractionation Schedules of High-Dose-Rate Intracavitary Brachytherapy (HDR-ICBT) in Patients With Cervical Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Eng-Yen [Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan (China); School of Traditional Chinese Medicine, Chang Gung University College of Medicine, Taiwan (China); Sun, Li-Min [Department of Radiation Oncology, Zuoying Armed Forces General Hospital, Kaohsiung, Taiwan (China); Lin, Hao [Department of Gynecologic Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan (China); Lan, Jen-Hong [Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan (China); Chanchien, Chan-Chao [Department of Gynecologic Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan (China); Huang, Yu-Jie; Wang, Chang-Yu [Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan (China); Wang, Chong-Jong, E-mail: cjw1010@adm.cgmh.org.tw [Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan (China)

    2013-01-01

    Purpose: To compare the treatment results of 2 fractionation schedules for high-dose-rate intracavitary brachytherapy (HDR-ICBT) in patients with cervical cancer. Methods and Materials: From June 2001 through January 2008, 267 patients with stage IB-IVA cervical cancer were enrolled in the study. All patients underwent 4-field pelvic irradiation and HDR-ICBT. The median central and parametrial doses were 39.6 Gy and 45 Gy, respectively. Patient underwent either 6 Gy Multiplication-Sign 4 (HDR-4) (n=144) or 4.5 Gy Multiplication-Sign 6 (HDR-6) (n=123) to point A of ICBT using {sup 192}Ir isotope twice weekly. The rates of overall survival, locoregional failure, distant metastasis, proctitis, cystitis, and enterocolitis were compared between HDR-4 and HDR-6. Results: There were no significant differences in the demographic data between HDR-4 and HDR-6 except for total treatment time. The 5-year proctitis rates were 23.0% and 21.5% in HDR-4 and HDR-6 (P=.399), respectively. The corresponding rates of grade 2-4 proctitis were 18.7% and 9.6% (P=.060). The corresponding rates of grades 3-4 proctitis were 5.2% and 1.3% (P=.231). Subgroup analysis revealed that HDR-4 significantly increased grade 2-4 proctitis in patients aged {>=}62 years old (P=.012) but not in patients aged <62 years (P=.976). The rates of overall survival, locoregional failure, distant metastasis, cystitis, and enterocolitis were not significantly different between HDR-4 and HDR-6 schedules. Conclusion: The small fraction size of HDR-ICBT is associated with grade 2 proctitis without compromise of prognosis in elderly patients. This schedule is suggested for patients who tolerate an additional 2 applications of HDR-ICBT.

  17. Genesis Silicon Carbide Concentrator Target 60003 Preliminary Ellipsometry Mapping Results

    Science.gov (United States)

    Calaway, M. J.; Rodriquez, M. C.; Stansbery, E. K.

    2007-01-01

    The Genesis concentrator was custom designed to focus solar wind ions primarily for terrestrial isotopic analysis of O-17/O-16 and O-18/O-16 to +/-1%, N-15/N-14 to +/-1%, and secondarily to conduct elemental and isotopic analysis of Li, Be, and B. The circular 6.2 cm diameter concentrator target holder was comprised of four quadrants of highly pure semiconductor materials that included one amorphous diamond-like carbon, one C-13 diamond, and two silicon carbide (SiC). The amorphous diamond-like carbon quadrant was fractured upon impact at Utah Test and Training Range (UTTR), but the remaining three quadrants survived fully intact and all four quadrants hold an important collection of solar wind. The quadrants were removed from the target holder at NASA Johnso n Space Center Genesis Curation Laboratory in April 2005, and have been housed in stainless steel containers under continual nitrogen purge since time of disintegration. In preparation for allocation of a silicon carbide target for oxygen isotope analyses at UCLA, the two SiC targets were photographed for preliminary inspection of macro particle contamination from the hard non-nominal landing as well as characterized by spectroscopic ellipsometry to evaluate thin film contamination. This report is focused on Genesis SiC target sample number 60003.

  18. FDG-PET of autoimmune-related pancreatitis: preliminary results

    International Nuclear Information System (INIS)

    The purpose of this retrospective study was to elucidate the fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) findings in autoimmune-related pancreatitis (AIP), which is a reversible chronic pancreatitis with an autoimmune cause. The study group comprised six patients with clinically diagnosed AIP. After 370 MBq (10 mCi) of FDG had been injected intravenously, the abdomen and/or the whole body was scanned at 1 h post injection in all patients, and scanning was repeated at 2 h in four patients. PET findings were evaluated visually and/or semiquantitatively using the standardized uptake value (SUV). In four of the six patients, PET demonstrated intense uptake in the whole pancreas, which appeared swollen on computed tomography, and the accumulation increased with time in three patients. In one patient, intense focal uptake in the pancreatic head was observed, and the accumulation decreased over time. In the remaining patient, no abnormal accumulation in the pancreas was observed. Follow-up PET scanning after steroid therapy was performed in three patients, and intense FDG uptake was no longer observed. Our preliminary data show that AIP can cause intense FDG uptake in the pancreas. This fact, and the benign status of the condition, should be kept in mind when making a diagnosis with FDG-PET in patients with pancreatic disorders. (orig.)

  19. Phase II Study of Consolidation Chemotherapy After Concurrent Chemoradiation in Cervical Cancer: Preliminary Results

    International Nuclear Information System (INIS)

    Purpose: Our aim was to determine the efficacy of consolidation chemotherapy after concurrent chemoradiation (CCRT) using high-dose-rate brachytherapy in patients with locally advanced cervical carcinoma. Methods and Materials: Patients with cervical carcinoma (FIGO stage IB2-IVA) were treated with external beam radiation therapy to the whole pelvis (50.4 Gy) and high-dose-rate brachytherapy (24 Gy to point A). Cisplatin 60 mg/m2 (Day 1) and 5-fluorouracil 1000 mg/m2 (Days 1-5) were given every 3 weeks starting concurrently with the radiation and followed by 3 more cycles of consolidation for a total of 6 cycles. Results: Thirty patients (94%) received 3 more cycles of post-CCRT consolidation chemotherapy and were evaluable for the toxicity and efficacy of consolidation. The most common toxicities of Grade 2 or higher were nausea or vomiting (47%) and anemia (33%). Late complications of the rectum and bladder occurred in 13% and 6% of the patients, respectively. The clinical complete response rate was 87% (95% CI, 75%-99%). During a median follow-up of 27 months (range, 6-58 months), 5 patients (17%) had recurrence; the sites of failure were 3 (10%) inside the radiation field and 2 (7%) outside the radiation field. The estimated 3-year progression-free survival rate was 83% (95% CI, 67%-99%) and overall survival rate was 91% (95% CI, 79%-100%). Conclusions: Consolidation chemotherapy after CCRT is well tolerated and effective in patients with locally advanced cervical carcinoma. A prospective randomized trial to compare this treatment strategy with standard CCRT seems to be worthwhile

  20. Interstitial brachytherapy dosimetry update

    International Nuclear Information System (INIS)

    In March 2004, the American Association of Physicists in Medicine (AAPM) published an update to the AAPM Task Group No. 43 Report (TG-43) which was initially published in 1995. This update was pursued primarily due to the marked increase in permanent implantation of low-energy photon-emitting brachytherapy sources in the United States over the past decade, and clinical rationale for the need of accurate dosimetry in the implementation of interstitial brachytherapy. Additionally, there were substantial improvements in the brachytherapy dosimetry formalism, accuracy of related parameters and methods for determining these parameters. With salient background, these improvements are discussed in the context of radiation dosimetry. As an example, the impact of this update on the administered dose is assessed for the model 200 103Pd brachytherapy source. (authors)

  1. Risk analysis of brachytherapy events

    International Nuclear Information System (INIS)

    For prevention radiological events it is necessary to identify hazardous situation and to analyse the nature of committed errors. Though the recommendation on the classification and prevention of radiological events: Radiological accidents has been prepared in the framework of Czech Society of Radiation Oncology, Biology and Physics and it was approved by Czech regulatory body (SONS) in 1999, only a few reports have been submitted up to now from brachytherapy practice. At the radiotherapy departments attention has been paid more likely to the problems of dominant teletherapy treatments. But in the two last decades the usage of brachytherapy methods has gradually increased because .nature of this treatment well as the possibilities of operating facility have been completely changed: new radionuclides of high activity are introduced and sophisticate afterloading systems controlled by computers are used. Consequently also the nature of errors, which can occurred in the clinical practice, has been changing. To determine the potentially hazardous parts of procedure the so-called 'process tree', which follows the flow of entire treatment process, has been created for most frequent type of applications. Marking the location of errors on the process tree indicates where failures occurred and accumulation of marks along branches show weak points in the process. Analysed data provide useful information to prevent medical events in brachytherapy .The results strength the requirements given in Recommendations of SONS and revealed the need for its amendment. They call especially for systematic registration of the events. (authors)

  2. Updated results of high-dose rate brachytherapy and external beam radiotherapy for locally and locally advanced prostate cancer using the RTOG-ASTRO phoenix definition

    Directory of Open Access Journals (Sweden)

    Antonio C. Pellizzon

    2008-06-01

    Full Text Available PURPOSE: To evaluate the prognostic factors for patients with local or locally advanced prostate cancer treated with external beam radiotherapy (RT and high dose rate brachytherapy (HDR according to the RTOG-ASTRO Phoenix Consensus Conference. MATERIALS AND METHODS: The charts of 209 patients treated between 1997 and 2005 with localized RT and HDR as a boost at the Department of Radiation Oncology, AC Camargo Hospital, Sao Paulo, Brazil were reviewed. Clinical and treatment parameters i.e.: patient's age, Gleason score, clinical stage, initial PSA (iPSA, risk group (RG for biochemical failure, doses of RT and HDR were evaluated. Median age and median follow-up time were 68 and 5.3 years, respectively. Median RT and HDR doses were 45 Gy and 20 Gy. RESULTS: Disease specific survival (DSS at 3.3 year was 94.2%. Regarding RG, for the LR (low risk, IR (intermediate risk and HR (high risk, the DSS rates at 3.3 years were 91.5%, 90.2% and 88.5%, respectively. On univariate analysis prognostic factors related to DSS were RG (p = 0.040, Gleason score ≤ 6 ng/mL (p = 0.002, total dose of HDR ≥ 20 Gy (p < 0.001 On multivariate analysis the only statistical significant predictive factor for biochemical control (bNED was the RG, p < 0.001 (CI - 1.147-3.561. CONCLUSIONS: Although the radiation dose administered to the prostate is an important factor related to bNED, this could not be established with statistical significance in this group of patients. To date , in our own experience, HDR associated to RT could be considered a successful approach in the treatment of prostate cancer.

  3. Updated results of high-dose rate brachytherapy and external beam radiotherapy for locally and locally advanced prostate cancer using the RTOG-ASTRO phoenix definition

    International Nuclear Information System (INIS)

    Purpose: To evaluate the prognostic factors for patients with local or locally advanced prostate cancer treated with external beam radiotherapy (RT) and high dose rate brachytherapy (HDR) according to the RTOG-ASTRO Phoenix Consensus Conference. Materials and methods: The charts of 209 patients treated between 1997 and 2005 with localized RT and HDR as a boost at the Department of Radiation Oncology, AC Camargo Hospital, Sao Paulo, Brazil were reviewed. Clinical and treatment parameters i.e.: patient's age, Gleason score, clinical stage, initial PSA (iPSA), risk group (RG) for biochemical failure, doses of RT and HDR were evaluated. Median age and median follow-up time were 68 and 5.3 years, respectively. Median RT and HDR doses were 45 Gy and 20 Gy. Results: Disease specific survival (DSS) at 3.3 year was 94.2%. Regarding RG, for the LR (low risk), IR (intermediate risk) and HR (high risk), the DSS rates at 3.3 years were 91.5%, 90.2% and 88.5%, respectively. On univariate analysis prognostic factors related to DSS were RG (p = 0.040), Gleason score ≤ 6 ng/mL (p = 0.002), total dose of HDR ≥ 20 Gy (p < 0.001) On multivariate analysis the only statistical significant predictive factor for biochemical control (bNED) was the RG, p < 0.001 (CI -1.147-3.561). Conclusions: Although the radiation dose administered to the prostate is an important factor related to bNED, this could not be established with statistical significance in this group of patients. To date , in our own experience, HDR associated to RT could be considered a successful approach in the treatment of prostate cancer. (author)

  4. Preliminary Cluster Size and Efficiencies results of CMS RPC at GIF++

    CERN Document Server

    Gonzalez Blanco Gonzalez, Genoveva

    2016-01-01

    A brief description and first preliminary results of the Efficiencies and Cluster Size measurements of the CMS Resistive Plate Chambers, will be presented inside the Gamma Irradiation Facility GIF++ at CERN. Preliminary studies that sets the base performance measurements of CMS RPC for starting aging studies.

  5. Preliminary Results on Sediment Sorting Under Intense Bedload Transport

    Science.gov (United States)

    Hernandez Moreira, R. R.; Vautin, D.; Mathews, S. L.; Kuprenas, R.; Viparelli, E.

    2014-12-01

    Previous experiments show that parallel-laminated deposits are emplaced under upper plane bed regime by the migration of small-amplitude, long-wavelength bedforms. The present research focuses on how sediment is sorted under upper plane bed and sheet flow transport regimes, and whether parallel-lamination is inhibited during sheet flow transport. The problem of studying the sorting of sediment under so intense transport conditions is plagued by the uncertainties related to flow resistances and bedload transport rates. We simplify the problem by first running the experiments with uniform sediment, to establish a baseline that will aid in the design of the experiments with poorly sorted material. We are running experiments at the Hydraulics Laboratory of the Department of Civil and Environmental Engineering at the University of South Carolina in Columbia, in a unidirectional sediment-feed flume, 9 meters long by 0.2 meters wide, of which 7 meters are used as test section. During the experiments, water surface and bed elevations are periodically measured to characterize the global parameters of the flow, e.g. mean flow velocity and bed shear stress. When the flow and the sediment transport reach conditions of mobile bed equilibrium, bed elevation fluctuations are measured with ultrasonic transducer systems at six fixed locations. Channel bed aggradation is then induced by slowly raising the tail gate of the flume such that there is no change in transport regime, as confirmed by additional measurements of water surface and bed elevation and bed elevation fluctuations. Preliminary observations under upper plane bed regime show the formation of the small-amplitude and long-wavelength bedforms, as well as hints of parallel lamination in the deposits. In the near future we aim to achieve sheet flow transport conditions with both uniform and non-uniform grain size distributions to look at the internal structure of the emplaced deposit.

  6. Microbial extremophiles from the 2008 Schirmacher Oasis Expedition: preliminary results

    Science.gov (United States)

    Hoover, Richard B.; Pikuta, Elena V.; Townsend, Alisa; Anthony, Joshua; Guisler, Melissa; McDaniel, Jasmine; Bej, Asim; Storrie-Lombardi, Michael

    2008-08-01

    Among the most interesting targets for Astrobiology research are the polar ice caps and the permafrost of Mars and the ice and liquid water bodies that may lie beneath the frozen crusts of comets, the icy moons of Jupiter (Europa, Io and Ganymede) and Saturn (Titan and Enceladus). The permanently ice-covered lakes of Antarctica, such as Lake Vostok and Lake Untersee, provide some of the best terrestrial analogues for these targets. The 2008 International Tawani Schirmacher Oasis/Lake Untersee Expeditions have been organized to conduct studies of novel microbial extremophiles and investigate the biodiversity of the glaciers and ice-covered lakes of Dronning Maud Land, East Antarctica. This paper describes the preliminary analysis of the anaerobic microbial extremophiles isolated from samples collected during the 2008 International Schirmacher Oasis Antarctica Reconnaissance Expedition. These samples showed great diversity of psychrophlic and psychrotolerant bacteria. Six new anaerobic strains have been isolated in pure cultures and partially characterized. Two of them (strains ARHSd-7G and ARHSd-9G) were isolated from a small tidal pool near the colony of African Penguins Spheniscus demersus. Strain ARHSd-7G was isolated on mineral anaerobic medium with 3 % NaCl, pH 7 and D-glucose, it has motile, vibrion shape cells, and is Gram variable. Strain ARHSd-9G grew on anaerobic, alkaline medium with pH 9 and 1 % NaCl at 3°C. The substrate was D-glucose supplemented with yeast extract (0.05 %). Cells of strain ARHSd-9G had morphology of straight or slightly curved elongated rods and demonstrated unusual optical effects under dark-field visible light microscopy. The cells were spore-forming and Gram positive. From the mat sample collected near Lake Zub, the new strain LZ-3 was isolated in pure culture at 3°C. Strain LZ-3 was anaerobic and grew on 0.5 % NaCl mineral medium with Dglucose as a substrate. The gram positive cells were spore-forming. They exhibited a

  7. The Mount Logan (Yukon) Ice Cores: Preliminary Results

    Science.gov (United States)

    Fisher, D. A.

    2004-05-01

    Bourgeois, Mike Demuth, David Fisher, Roy Koerner,Chris Zdanowicz, James Zheng. University of Ottawa: Ian Clarke,Raphaelle Cardyn. National Institute of Polar Research (Japan): Kumiko Goto-Azuma University of New Hampshire: Cam Wake, Kaplan Yalcin. University of Maine: Karl Kreutz, Paul Mayewski, Erich Osterberg. Arctic Institute of North America: Gerald Holdsworth. University of Washington: Eric J. Steig, Summer B. Rupper. University of Copenhagen: Dorthe Dahl-Jensen. David Fisher is the presenter but many contributed to what is a joint preliminary offering.

  8. The Sunphotometer Airborne Validation Experiment 2012: Preliminary Results

    Science.gov (United States)

    Estellés, Victor; Marenco, Franco; Ryder, Claire L.; Campanelli, Monica; Expósito, Francisco; Solá, Yolanda; Segura, Sara; Marcos, Carlos; Toledano, Carlos; Berjón, Alberto; Guirado, Carmen; Claxton, Bernard; Todd, Martin

    2013-04-01

    to provide detailed vertically resolved aerosol measurements, in order to compare these to sunphotometer retrievals. Simultaneously, 4 different ground AERONET - Cimel sites were deployed in the Tenerife island, at different latitudes and altitudes for further investigation of spatial and vertical variability. Three of these sites also measured solar radiation components with CM21 pyranometers and CHP1 pirheliometers, for further research on radiative forcing of aerosols. One site was equipped with a Prede POM sun-sky radiometer for comparison with Cimel sunphotometer. On the other hand, for the FENNEC campaign another AERONET Cimel sunphotometer was deployed in Zouerate (Mauritania). The ideal conditions for such a comparison consisted of cloudless skies and high mineral aerosol burdens, brought by the Saharan outflow. Although these conditions were not reached in the Tenerife area during the scheduled field campaign, appropriate conditions were met in western Mauritania, over the AERONET Zouerate site. In this study, we perform a preliminary analysis of the columnar properties of aerosols in the Canary Islands and West Sahara areas during the FENNEC 2011 and FENNEC-SAVEX 2012 field campaigns, with an emphasis on the comparison between the size distributions retrieved from both AERONET and SKYRAD algorithms using the Zouerate Cimel site data. Validation of the vertical integrated aerosol size distributions will be also presented. References - M.Campanelli, V.Estelles, T. Smyth, T. Nakajima, M. Hashimoto, A.Lupi, C. Tomas, "Retrieval of aerosol radiative properties from sun-sky radiometers measurements of ESR network: comparison between the inversion codes Skyrad4.2.pack and the new Skyrad5.pack", European Aerosol Conference, 2011. - V. Estellés, M. Campanelli, M. P. Utrillas, F. Expósito, and J. A. Martínez-Lozano, "Comparison of AERONET and SKYRAD4.2 inversion products retrieved from a Cimel CE318 sunphotometer", Atmos. Meas. Tech. 5, 569—579, 2012.

  9. Dynamic rotating-shield brachytherapy

    International Nuclear Information System (INIS)

    Purpose: To present dynamic rotating shield brachytherapy (D-RSBT), a novel form of high-dose-rate brachytherapy (HDR-BT) with electronic brachytherapy source, where the radiation shield is capable of changing emission angles during the radiation delivery process.Methods: A D-RSBT system uses two layers of independently rotating tungsten alloy shields, each with a 180° azimuthal emission angle. The D-RSBT planning is separated into two stages: anchor plan optimization and optimal sequencing. In the anchor plan optimization, anchor plans are generated by maximizing the D90 for the high-risk clinical-tumor-volume (HR-CTV) assuming a fixed azimuthal emission angle of 11.25°. In the optimal sequencing, treatment plans that most closely approximate the anchor plans under the delivery-time constraint will be efficiently computed. Treatment plans for five cervical cancer patients were generated for D-RSBT, single-shield RSBT (S-RSBT), and 192Ir-based intracavitary brachytherapy with supplementary interstitial brachytherapy (IS + ICBT) assuming five treatment fractions. External beam radiotherapy doses of 45 Gy in 25 fractions of 1.8 Gy each were accounted for. The high-risk clinical target volume (HR-CTV) doses were escalated such that the D2cc of the rectum, sigmoid colon, or bladder reached its tolerance equivalent dose in 2 Gy fractions (EQD2 with α/β= 3 Gy) of 75 Gy, 75 Gy, or 90 Gy, respectively.Results: For the patients considered, IS + ICBT had an average total dwell time of 5.7 minutes/fraction (min/fx) assuming a 10 Ci192Ir source, and the average HR-CTV D90 was 78.9 Gy. In order to match the HR-CTV D90 of IS + ICBT, D-RSBT required an average of 10.1 min/fx more delivery time, and S-RSBT required 6.7 min/fx more. If an additional 20 min/fx of delivery time is allowed beyond that of the IS + ICBT case, D-RSBT and S-RSBT increased the HR-CTV D90 above IS + ICBT by an average of 16.3 Gy and 9.1 Gy, respectively.Conclusions: For cervical cancer patients, D

  10. Dynamic rotating-shield brachytherapy

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Yunlong [Department of Electrical and Computer Engineering, University of Iowa, 4016 Seamans Center, Iowa City, Iowa 52242 (United States); Flynn, Ryan T.; Kim, Yusung [Department of Radiation Oncology, University of Iowa, 200 Hawkins Drive, Iowa City, Iowa 52242 (United States); Yang, Wenjun [Department of Medical Physics, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, Wisconsin 53705 (United States); Wu, Xiaodong [Department of Electrical and Computer Engineering, University of Iowa, 4016 Seamans Center, Iowa City, Iowa 52242 and Department of Radiation Oncology, University of Iowa, 200 Hawkins Drive, Iowa City, Iowa 52242 (United States)

    2013-12-15

    Purpose: To present dynamic rotating shield brachytherapy (D-RSBT), a novel form of high-dose-rate brachytherapy (HDR-BT) with electronic brachytherapy source, where the radiation shield is capable of changing emission angles during the radiation delivery process.Methods: A D-RSBT system uses two layers of independently rotating tungsten alloy shields, each with a 180° azimuthal emission angle. The D-RSBT planning is separated into two stages: anchor plan optimization and optimal sequencing. In the anchor plan optimization, anchor plans are generated by maximizing the D{sub 90} for the high-risk clinical-tumor-volume (HR-CTV) assuming a fixed azimuthal emission angle of 11.25°. In the optimal sequencing, treatment plans that most closely approximate the anchor plans under the delivery-time constraint will be efficiently computed. Treatment plans for five cervical cancer patients were generated for D-RSBT, single-shield RSBT (S-RSBT), and {sup 192}Ir-based intracavitary brachytherapy with supplementary interstitial brachytherapy (IS + ICBT) assuming five treatment fractions. External beam radiotherapy doses of 45 Gy in 25 fractions of 1.8 Gy each were accounted for. The high-risk clinical target volume (HR-CTV) doses were escalated such that the D{sub 2cc} of the rectum, sigmoid colon, or bladder reached its tolerance equivalent dose in 2 Gy fractions (EQD2 with α/β= 3 Gy) of 75 Gy, 75 Gy, or 90 Gy, respectively.Results: For the patients considered, IS + ICBT had an average total dwell time of 5.7 minutes/fraction (min/fx) assuming a 10 Ci{sup 192}Ir source, and the average HR-CTV D{sub 90} was 78.9 Gy. In order to match the HR-CTV D{sub 90} of IS + ICBT, D-RSBT required an average of 10.1 min/fx more delivery time, and S-RSBT required 6.7 min/fx more. If an additional 20 min/fx of delivery time is allowed beyond that of the IS + ICBT case, D-RSBT and S-RSBT increased the HR-CTV D{sub 90} above IS + ICBT by an average of 16.3 Gy and 9.1 Gy, respectively

  11. In vitro study of UHMWPE/MWCNT – Preliminary results

    OpenAIRE

    Reis, J.; J. Potes; Capela e Silva, F.; Pereira, A.; S. Kanagaraj; Oliveira, M.; Simões, J.

    2008-01-01

    Reinforcement of ultra high molecular weight polyethylene (UHMWPE) by adding multiwalled carbon nanotubes (MWCNT) allows improvement of mechanical characteristics for biomedical applications. However, there is controversy when it comes to carbon nanotubes toxicity. Our objective was the in vitro study of UHMWPE/MWCNT. The results show good biocompatibility of the nanocomposite, comparable to results obtained by other authors.

  12. Sole conformal perioperative interstitial brachytherapy of early stage breast carcinoma using high-dose rate afterloading: longer-term results and toxicity

    International Nuclear Information System (INIS)

    Aims and Background: This study of high-dose-rate brachytherapy to the lumpectomy site as the sole radiation presents longer-term results and toxicity of accelerated partial-breast irradiation, using three-dimensional treatment planning. Materials and Methods: From March 2002 to July 2004, 25 patients were prospectively included in this study. Six patients were excluded because of definitive histology of lobular carcinoma or positive margin. The median age at the time of treatment was 63.2 years (range 44 - 77 years). Median follow- up of all patients was 44 months (range 30 - 53 months) with a minimum follow-up of 30 months. Radiation was delivered using the high-dose-rate remote after loader VariSource with 192Ir source. The patients received radiation twice a day at least 6 hours apart for a total of 10 fractions over five days with a single dose of 3.4 Gy. The total dose was 34.0 Gy prescribed as a minimum peripheral dose to match or minimally exceed the volume defined by the surgical clips as seen on computed-tomography (CT) scans. Free-hand technique allows conformal placement of the catheters to the shape of the lumpectomy cavity. Side-effects and toxicity were scored using the EORTC/RTOG scale. Results: At a median follow-up of 44 months none of the women had developed in-field breast recurrences, one patient had out-of-field recurrences and one patient presented distant metastases. There were no regional nodal recurrences. In each woman, target volume size in cm3 (median 91.3 cm3), dose volume histogram (DVH), and dose homogeneity index (DHI) were calculated. Median DHI was 0.42. Median volume of breast tissue receiving 100 % of the prescription dose, V100, was 87 %; and V150 48.5 %. We noticed two treatment complications: haematoma and abscess in the place of the tumour bed after extirpation. At last follow-up, all patients rated the overall cosmetic outcome as excellent or good. Conclusions: This method is suitable only for patients with histologically

  13. Electron and high-dose-rate brachytherapy boost in the conservative treatment of stage I-II breast cancer. First results of the randomized Budapest boost trial

    Energy Technology Data Exchange (ETDEWEB)

    Polgar, C.; Fodor, J. [National Institute of Oncology, Department of Radiotherapy, Budapest (Hungary); Orosz, Z. [National Institute of Oncology, Center of Experimental and Human Tumor Pathology Budapest (HU)] [and others

    2002-11-01

    Background and Aims: To evaluate the effect of electron and high-dose-rate brachytherapy (HDR BT) boost on local tumor control (LTC), side effects and cosmesis after breast-conserving surgery (BCS) in a prospective randomized study. Patients and Methods: 207 women with stage I-II breast cancer who underwent BCS were treated by 50 Gy irradiation to the whole breast and then randomly assigned to receive either a boost to the tumor bed (n=104) or no further radiotherapy (n=103). Boost treatments consisted of either 16 Gy electron irradiation (n=52) or 12-14.25 Gy HDR BT (n=52). Breast cancer-related events, side effects, and cosmetic results were assessed. Results: At a median follow-up of 5.3 years, the crude rate of local recurrence was 6.7% (7/104) with and 15.5% (16/103) without boost. The 5-year probability of LTC, relapse-free survival (RFS), and cancer-specific survival (CSS) was 92.7% vs 84.9% (p=0.049), 76.6% vs 66.2% (p=0.044), and 90.4% vs. 82.1% (p=0.053), respectively. There was no significant difference in LTC between patients treated with electron or HDR BT boost (94.2% vs 91.4%; p=0.74). On multivariate analysis, patient age <40 years (RR: 4.53), positive margin status (RR: 4.17), and high mitotic activity index (RR: 3.60) were found to be significant risk factors for local recurrence. The incidence of grade 2-3 side effects was higher in the boost arm (17.3% vs 7.8%; p=0.03). However, the rate of excellent/good cosmetic results was similar for the two arms (85.6% vs 91.3%; p=0.14). Cosmesis was rated as excellent/good in 88.5% of patients treated with HDR BT and 82.7% of patients with electron boost (p=0.29). Conclusions: Boost dose significantly improves LTC and RFS in patients treated with BCS and radiotherapy. In spite of the higher incidence of late side effects in the boost arm, boost dose is strongly recommended for patients at high risk for local recurrence. Positive or close margin status, high mitotic activity index, and young patient age

  14. Electron and high-dose-rate brachytherapy boost in the conservative treatment of stage I-II breast cancer. First results of the randomized Budapest boost trial

    International Nuclear Information System (INIS)

    Background and Aims: To evaluate the effect of electron and high-dose-rate brachytherapy (HDR BT) boost on local tumor control (LTC), side effects and cosmesis after breast-conserving surgery (BCS) in a prospective randomized study. Patients and Methods: 207 women with stage I-II breast cancer who underwent BCS were treated by 50 Gy irradiation to the whole breast and then randomly assigned to receive either a boost to the tumor bed (n=104) or no further radiotherapy (n=103). Boost treatments consisted of either 16 Gy electron irradiation (n=52) or 12-14.25 Gy HDR BT (n=52). Breast cancer-related events, side effects, and cosmetic results were assessed. Results: At a median follow-up of 5.3 years, the crude rate of local recurrence was 6.7% (7/104) with and 15.5% (16/103) without boost. The 5-year probability of LTC, relapse-free survival (RFS), and cancer-specific survival (CSS) was 92.7% vs 84.9% (p=0.049), 76.6% vs 66.2% (p=0.044), and 90.4% vs. 82.1% (p=0.053), respectively. There was no significant difference in LTC between patients treated with electron or HDR BT boost (94.2% vs 91.4%; p=0.74). On multivariate analysis, patient age <40 years (RR: 4.53), positive margin status (RR: 4.17), and high mitotic activity index (RR: 3.60) were found to be significant risk factors for local recurrence. The incidence of grade 2-3 side effects was higher in the boost arm (17.3% vs 7.8%; p=0.03). However, the rate of excellent/good cosmetic results was similar for the two arms (85.6% vs 91.3%; p=0.14). Cosmesis was rated as excellent/good in 88.5% of patients treated with HDR BT and 82.7% of patients with electron boost (p=0.29). Conclusions: Boost dose significantly improves LTC and RFS in patients treated with BCS and radiotherapy. In spite of the higher incidence of late side effects in the boost arm, boost dose is strongly recommended for patients at high risk for local recurrence. Positive or close margin status, high mitotic activity index, and young patient age

  15. Uranium-liquid argon calorimetry: preliminary results from the DO tests

    International Nuclear Information System (INIS)

    The motivations for using uranium and liquid argon in sampling calorimetry are reviewed and the pros and cons of the technique are discussed. Preliminary results of the DO uranium-liquid argon test program are presented. 9 refs., 7 figs

  16. PRELIMINARY RESULTS OF INTRA CYTOPLASMIC SPERM INJECTION (ICSI) APPLIED ON RABBIT : A TECHNICAL NOTE.

    OpenAIRE

    Escribá, M.J.; García- Ximénez, F.

    1999-01-01

    Abstract not available. Escribá, M.; García- Ximénez, F. (1999). PRELIMINARY RESULTS OF INTRA CYTOPLASMIC SPERM INJECTION (ICSI) APPLIED ON RABBIT : A TECHNICAL NOTE. http://hdl.handle.net/10251/10364.

  17. 77 FR 66580 - Certain Preserved Mushrooms From India: Preliminary Results of Antidumping Duty Administrative...

    Science.gov (United States)

    2012-11-06

    ... India, 64 FR 8311 (February 19, 1999) (Mushroom Antidumping Duty Order), remains dispositive... International Trade Administration Certain Preserved Mushrooms From India: Preliminary Results of Antidumping... review of the antidumping duty order on certain preserved mushrooms (mushrooms) from India. The period...

  18. Event-Based Control over Networks: Some Research Questions and Preliminary Results

    OpenAIRE

    Henningsson, Toivo; Cervin, Anton

    2006-01-01

    The paper discusses some research questions related to event-based control over networks and presents preliminary results regarding event-based minimum-variance control of first-order systems with specified minimum inter-event times.

  19. Plasma technology for treating hazardous, radioactive, and mixed waste: Critical technology issues and preliminary results

    International Nuclear Information System (INIS)

    Plasma processing technology is currently being considered for the treatment of hazardous, radioactive, and mixed waste. The paper reviews the technology and proposes critical issues to be addressed in applying plasma to waste treatment. Preliminary results from a small scale plasma arcjet experiment with acetone were compared with predictions from ASPEN, a chemical equilibrium code. Preliminary results indicate that proper mixing and models describing the high temperature plasma chemical kinetics are needed to adequately predict the composition of the offgases

  20. Mature results of a randomized trial comparing two fractionation schedules of high dose rate endoluminal brachytherapy for the treatment of endobronchial tumors

    International Nuclear Information System (INIS)

    To determine the efficacy of high dose rate endobronchial brachytherapy (HDR-BT) for the treatment of centrally located lung tumors, two different fractionation schedules were compared regarding local tumor response, side effects and survival. Mature retrospective results with longer follow-up and more patients were analyzed. Initial results were published by Huber et al. in 1995. 142 patients with advanced, centrally located malignant tumors with preferential endoluminal growth were randomized to receive 4 fractions of 3.8 Gy (time interval: 1 week, n = 60, group I) or 2 fractions of 7.2 Gy (time interval: 3 weeks, n = 82, group II) endobronchial HDR-BT. Age, gender, tumor stage, Karnofsky Performance Score and histology were equally distributed between both groups. Local tumor response with 2 fractions of 7.2 Gy was significantly higher as compared to 4 fractions of 3.8 Gy (median 12 vs. 6 weeks; p ≤ 0.015). Median survival was similar in both groups (19 weeks in the 4 fractions group vs. 18 weeks in the 2 fractions group). Fatal hemoptysis was less frequent following irradiation with 2 × 7.2 Gy than with 4 × 3.8 Gy, although the difference did not achieve statistical significance (12.2% vs. 18.3%, respectively. p = 0,345). Patients presenting with squamous cell carcinoma were at higher risk of bleeding compared to other histology (21.9% vs. 9%, p = 0,035). Multivariate analysis with regard to overall survival, revealed histology (p = 0.02), Karnofsky Performance Score (p < 0.0001) and response to therapy (p < 0.0001) as significant prognostic factors. For patients showing complete response the median survival was 57 weeks, while for patients with progressive disease median survival time was 8 weeks, p < 0.0001. The KPS at the start of the treatment was significantly correlated with survival. Patients presenting with a KPS ≤ 60 at the start had a significantly (p = 0,032) shorter survival time (10 weeks) than patients with a KPS > 60 (29 weeks). Moreover

  1. Preliminary results of standard quantitative analysis by ED-XRF

    International Nuclear Information System (INIS)

    A comparison between the results of elemental concentration proposed by XRS-FP software , using data obtained by EDXRF technique with those obtained by stoichiometric calculation was performed. For this purpose, five standard samples of known compounds were produced: two lead- oxide, magnesium chloride and iodine in controlled amounts. The compounds were subsequently mixed and compressed to form tablets. The samples were irradiated in three endpoints, according to an orientation. The measurements were performed at the Laboratory for Radiological UTFPR using X-123SDD the Amptek detector and X-ray tube with silver target from the same manufacturer. The operating conditions tube were 05μA current to a 40 kV voltage. Finally, the 15 spectra analyzed with the software to determine the concentration of chlorine, iodine and lead. Data from this analysis were compared with results expected in stoichiometric calculations. The data provided by the program, a convergence of results, indicating homogeneity of the samples was found. Compared to the stoichiometric calculation, a considerable discrepancy that may be the result of a misconfiguration or contamination of the sample was found. At the end, we created a proposal for continuation of the work using an auxiliary calculation should be developed in the next step

  2. Preliminary results of standard quantitative analysis by ED-XRF

    Energy Technology Data Exchange (ETDEWEB)

    Lara, Alessandro L. de; Franca, Alana C.; Neto, Manoel R.M.; Paschuk, Sergei A., E-mail: alellara@hotmail.com [Universidade Tecnologica Federal do Parana (UTFPR), Curitiba, PR (Brazil). Dept. de Fisica; Denyak, Valeriy, E-mail: denyak@gmail.com [Instituto de Pesquisa Pele Pequeno Principe (IPPP), Curitiba, PR (Brazil)

    2013-07-01

    A comparison between the results of elemental concentration proposed by XRS-FP software , using data obtained by EDXRF technique with those obtained by stoichiometric calculation was performed. For this purpose, five standard samples of known compounds were produced: two lead- oxide, magnesium chloride and iodine in controlled amounts. The compounds were subsequently mixed and compressed to form tablets. The samples were irradiated in three endpoints, according to an orientation. The measurements were performed at the Laboratory for Radiological UTFPR using X-123SDD the Amptek detector and X-ray tube with silver target from the same manufacturer. The operating conditions tube were 05μA current to a 40 kV voltage. Finally, the 15 spectra analyzed with the software to determine the concentration of chlorine, iodine and lead. Data from this analysis were compared with results expected in stoichiometric calculations. The data provided by the program, a convergence of results, indicating homogeneity of the samples was found. Compared to the stoichiometric calculation, a considerable discrepancy that may be the result of a misconfiguration or contamination of the sample was found. At the end, we created a proposal for continuation of the work using an auxiliary calculation should be developed in the next step.

  3. Preliminary results of in vitro propagation of Guayule

    Science.gov (United States)

    Dastoor, M. N.; Schubert, W. W.; Petersen, G. R.

    1981-01-01

    Guayule, Parthenium argentatum Gray, was first established in tissue culture by Bonner and Arreguin (1950) as a means to study the effects of various chemicals and extracts on rubber production. The propagation of whole guayule plants from tissue culture, however, has not been accomplished. The reported investigation is concerned with such an objective. In an attempt to stimulate rubber production in Guayule, Yokoyama et al. (1977) sprayed juvenile plants with 2-(3,4-dichloro-phenoxy)triethylamine (TEA derivative). This treatment resulted in increased isoprenoid levels in the plant tissue. In the current investigation, experiments were conducted to study the effect of TEA derivative on in vitro cultures. It was found that a suppression of callus formation occurs at a 10 mg/L concentration of TEA derivative with a resultant increase of shoot formation. Lower and higher concentrations of TEA derivative promote callus formation.

  4. Magnetic field studies at Jupiter by Voyager 2 - Preliminary results

    Science.gov (United States)

    Ness, N. F.; Acuna, M. H.; Lepping, R. P.; Burlaga, L. F.; Behannon, K. W.; Neubauer, F. M.

    1979-01-01

    The Voyager 2 magnetic field experiment, for which the instrumentation is identical to that on Voyager 1, operated flawlessly throughout the second Jupiter encounter. The paper presents a brief overview of the results obtained to date on the Jovian magnetosphere, the bow shock, the magnetopause, and the extended magnetic tail. The results and the magnetic field geometry confirm the earlier conclusion from Voyager 1 that Jupiter has an enormous magnetic tail, approximately 300-400 Jupiter radii in diameter, trailing behind the planet with respect to the supersonic flow of the solar wind. Additional observations of the distortion of the inner magnetosphere by a concentrated plasma show a spatial merging of the equatorial magnetodisk current with the current sheet in the magnetic tail. Disturbances near Ganymede are discussed.

  5. Preliminary results on Alfven wave system in the TCABR tokamak

    International Nuclear Information System (INIS)

    A brief review of the Alfven Wave Excitation System (AWES) designed for the TCABR tokamak and the first experimental results on RF plasma heating are presented. One of four antenna modules has been completely installed in the vacuum chamber and the initial experiments were carried out in the low power regime using the four-phase RF generator. The main objectives were the antenna tuning according to the typical plasma parameters of TCABR and the evaluation of the antenna parasitic loading, as well as the calibration of the RF diagnostic tools in real discharge conditions. The first results have been obtained with standard diagnostics and with the RF signals measured using high sampling rate digital oscilloscopes. They showed that daily antenna cleaning and correct wave helicity excitation reduce significantly the parasitic loading and are crucial for efficient plasma coupling

  6. How Resilient Are Our Societies? Analyses, Models, and Preliminary Results

    OpenAIRE

    Florio, Vincenzo; Pajaziti, Arianit

    2015-01-01

    Traditional social organizations such as those for the management of healthcare and civil defence are the result of designs and realizations that matched well with an operational context considerably different from the one we are experiencing today: A simpler world, characterized by a greater amount of resources to match less users producing lower peaks of requests. The new context reveals all the fragility of our societies: unmanageability is just around the corner unless we do not complemen...

  7. Processed Vietnamese ginseng: Preliminary results in chemistry and biological activity

    OpenAIRE

    Le, Thi Hong Van; Lee, Seo Young; Kim, Tae Ryong; Kim, Jae Young; Kwon, Sung Won; NGUYEN, NGOC KHOI; Park, Jeong Hill; Nguyen, Minh Duc

    2013-01-01

    Background This study was carried out to investigate the effect of the steaming process on chemical constituents, free radical scavenging activity, and antiproliferative effect of Vietnamese ginseng. Methods Samples of powdered Vietnamese ginseng were steamed at 120°C for various times and their extracts were subjected to chemical and biological studies. Results Upon steaming, contents of polar ginsenosides, such as Rb1, Rc, Rd, Re, and Rg1, were rapidly decreased, whereas less polar ginsenos...

  8. Impediments to Marketing African Natural products From Ghana: Preliminary Results

    OpenAIRE

    Govindasamy, Ramu; Onyango, Benjamin M.; Puduri, Venkata S.; Simon, James E.; Asante-Dartey, Juliana; Arthur, Hanson; Diawuo, Bismarck; Acquaye, Dan

    2006-01-01

    For most of the African countries agriculture still remains the mainstay of the economies supplying both food and incomes via marketable surpluses. However, many odds against agriculture such low productivity, poor prices, and drought among others make it unsustainable. Results thus far show that such dependence has contributed little to neither economic development nor growth. Still many of its people living on and from agriculture remain poor, and are susceptible to hunger and malnutrition....

  9. Preliminary results from an indoor radon thoron survey in Hungary

    International Nuclear Information System (INIS)

    More than half of the radiation dose of natural origin comes from radon. However, according to some surveys in certain cases, the radiation dose originating from thoron may be considerable. Among the factors disturbing the measurement of radon, the presence of thoron may also influence the measured radon value, making the estimated radiation exposure imprecise. Thoron has previously been surveyed, mainly in Asia; however, recent surveys for some European locations have found that significant thoron concentrations also need to be considered. In this survey, several types of commercially available SSNTDs (solid-state nuclear track detectors) capable of measuring both radon and thoron were placed at the same time in 73 houses and 7 workplaces in Hungary with 3-month exposition periods. In order to measure thoron, the distance of the detector sets was fixed as 15-20 cm from the walls. The radon concentration was measured with five types of SSNTDs: NRPB, NRPB SSI, Raduet, DTPS and DRPS. The first four types had relatively good accordance (within ± 10 %), but the results of the DRPS detectors were considerably lower when compared with other detectors for radon concentrations over 100 Bq m-3. The thoron averages were provided by two different types of detectors: Raduet and DTPS. The difference between their average results was more than 30 % and was six times the maximum values. Therefore, the thoron measurement results were judged to be erroneous, and their measurement protocol should be clearly established for future work. (authors)

  10. Long-Term Results of an RTOG Phase II Trial (00-19) of External-Beam Radiation Therapy Combined With Permanent Source Brachytherapy for Intermediate-Risk Clinically Localized Adenocarcinoma of the Prostate

    International Nuclear Information System (INIS)

    Purpose: External-beam radiation therapy combined with low—doserate permanent brachytherapy are commonly used to treat men with localized prostate cancer. This Phase II trial was performed to document late gastrointestinal or genitourinary toxicity as well as biochemical control for this treatment in a multi-institutional cooperative group setting. This report defines the long-term results of this trial. Methods and Materials: All eligible patients received external-beam radiation (45 Gy in 25 fractions) followed 2–6 weeks later by a permanent iodine 125 implant of 108 Gy. Late toxicity was defined by the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer late radiation morbidity scoring scheme. Biochemical control was defined by the American Society for Therapeutic Radiology and Oncology (ASTRO) Consensus definition and the ASTRO Phoenix definition. Results: One hundred thirty-eight patients were enrolled from 20 institutions, and 131 were eligible. Median follow-up (living patients) was 8.2 years (range, 2.7–9.3 years). The 8-year estimate of late grade >3 genitourinary and/or gastrointestinal toxicity was 15%. The most common grade >3 toxicities were urinary frequency, dysuria, and proctitis. There were two grade 4 toxicities, both bladder necrosis, and no grade 5 toxicities. In addition, 42% of patients complained of grade 3 impotence (no erections) at 8 years. The 8-year estimate of biochemical failure was 18% and 21% by the Phoenix and ASTRO consensus definitions, respectively. Conclusion: Biochemical control for this treatment seems durable with 8 years of follow-up and is similar to high—dose external beam radiation alone or brachytherapy alone. Late toxicity in this multi-institutional trial is higher than reports from similar cohorts of patients treated with high—dose external-beam radiation alone or permanent low—doserate brachytherapy alone, perhaps suggesting further attention to strategies that

  11. Status and preliminary results of the ANAIS experiment at Canfranc

    International Nuclear Information System (INIS)

    ANAIS (Annual Modulation with NaI's) is an experiment planned to investigate seasonal modulation effects in the signal of galactic WIMPs using up to 107 kg of NaI(Tl) in the Canfranc Underground Laboratory (Spain). A prototype using one single crystal (10.7 kg) is being developed before the installation of the complete experiment; the first results presented here show an average background level of 1.2 counts/(keV kg day) from threshold (Ethr ∼ 4 keV) up to 10 keV

  12. Preliminary results of ITEC over an equatorial station

    International Nuclear Information System (INIS)

    Total electron content (TEC) was obtained from bottomside ionograms recorded at an equatorial station (Ouagadougou, 12.4 deg. N, 358.5 deg. E). Variability in TEC obtained in this way (ITEC) was investigated. Diurnal, seasonal and solar cycle effects were observed. Both absolute and relative variability were considered. The results obtained were compared with those of another equatorial station (Ghana, 5.63 deg. N, 359.8 deg. E) where the TEC was obtained by the Faraday rotation technique. The variations in variability at both stations follow the same trend. (author)

  13. ATOM PROBE STUDY OF TITANIUM BASE ALLOYS : PRELIMINARY RESULTS

    OpenAIRE

    Menand, A.; Chambreland, S.; Martin, C

    1986-01-01

    Two different titanium base alloys, Ti46 Al54 and Ti88.8 Cu2.3, Al8.9, have been studied by atom probe microanalysis. A precipitate of Ti2 Al was analysed in the binary alloys. Micro-analysis of Ti Cu Al alloy revealed the presence of Copper enriched zones. The study has also exhibited a penetration of Hydrogen in the samples, probably due to preparation technique. The results demonstrate the feasibility of studies on titanium base alloys by mean of atom probe.

  14. Development and preliminary results of radio frequency ion source

    Energy Technology Data Exchange (ETDEWEB)

    Xie, Yahong, E-mail: xieyh@ipp.ac.cn; Hu, Chundong; Jiang, Caichao; Chen, Yuqian; Gu, Yumin; Su, Renxue; Xie, Yuanlai; Liu, Zhimin [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China)

    2016-02-15

    A radio frequency (RF) ion source was designed and developed for neutral beam injector. A RF driver test bed was used with a RF generator with maximum power of 25 kW with 1 MHz frequency and a matching box. In order to study the characteristic of RF plasma generation, the capacitance in the matching box was adjusted with different cases. The results show that lower capacitance will better the stability of the plasma with higher RF power. In the future, new RF coils and matching box will be developed for plasma generators with higher RF power of 50 kW.

  15. Interdisciplinary investigation of Boda clay-stone formation - preliminary results

    International Nuclear Information System (INIS)

    Document available in extended abstract form only. The aim of GEOCHEM Ltd.'s, partly EU-funded project, which started in 2008, was the comparison of the results of laboratory and field investigations, the assessment of their differences and the determination of scale in case of Boda clay-stone Formation (BCF - Mecsek Mts.). The formation has been researched as the potential host rock for the deep geological disposal of high level radioactive waste since 1999. Although the rock has been analyzed from numerous various aspects, its reservoir characteristics are still less known. As the achievement of the project's research and development activity, the reliable and fast measurement of petrophysical features became possible, as well as the comparison of results with the results of geophysical and geochemical investigations and their complex assessment. Petrophysical investigations of BCF have also been performed by the SzKFI, Geopard Ltd. and by the Department of Reservoir Engineering of Research Institute of Applied Chemistry, University of Miskolc (ME AFKI) that showed 0.04 - 3 % porosity and between 10-15- 10-21 m2 water permeability values. Similar, 10-15 and 10-19 m2 permeability values were produced by the in-situ packer tests of Mecsekerc Plc. The results clearly show that this rock is extremely tight and its petrophysical characteristics are hard to measure. An even more serious problem is to determine how laboratory results can be extended to the rock body itself, that is, can the scale dependence of data be determined. The project tries to realize this goal in three steps, by well logs in the given borehole, by CT and core scanning on the whole core and by mineralogical, geophysical, pore structure and permeability measurements performed on plugs prepared for laboratory investigations. Individual sub-tasks are performed as subcontractors by the Eoetvoes Lorand Geophysical Institute, the Research Institute of Applied Earth Sciences of the University of Miskolc

  16. Design and preliminary results of the IMA plasma focus experiment

    International Nuclear Information System (INIS)

    The present paper describes the design, operation and characteristics of aton 1MA plasma focus device, which built in egypt at the plasma physics department, N.R.C., atomic energy authority. The main parts of the system are: the coaxial electrodes of mather type, the expansion chamber, the condenser bank of 75 kJ stored energy, the pressurized spark gap switches and Blumlein trigger system. Measurement of the breakdown voltage between plasma focus electrodes and discharge current, using half of the condenser bank, showed that, for Uc h = 32 kV, the discharge current was 0.5 Ma. In the discharge current and voltage traces a sharp drop in discharge current correspondingly to a sudden rise in voltage have been observed, which characterize the focus regime. Time structure of the x-ray emission measurements have been performed by means of scintillation detectors. by using a hydrogen gas the results showed that, the x-ray intensity is increased with increasing the hydrogen gas pressure. plasma sheath current density, J-Z distribution in axial direction during the acceleration phase of the discharge is studied, using a miniature Rogovsky coil. The results cleared that Jz is increased with the axial distance from breech to muzzle at different hydrogen gas pressures. 12 figs

  17. Simulation of diurnal thermal energy storage systems: Preliminary results

    Science.gov (United States)

    Katipamula, S.; Somasundaram, S.; Williams, H. R.

    1994-12-01

    This report describes the results of a simulation of thermal energy storage (TES) integrated with a simple-cycle gas turbine cogeneration system. Integrating TES with cogeneration can serve the electrical and thermal loads independently while firing all fuel in the gas turbine. The detailed engineering and economic feasibility of diurnal TES systems integrated with cogeneration systems has been described in two previous PNL reports. The objective of this study was to lay the ground work for optimization of the TES system designs using a simulation tool called TRNSYS (TRaNsient SYstem Simulation). TRNSYS is a transient simulation program with a sequential-modular structure developed at the Solar Energy Laboratory, University of Wisconsin-Madison. The two TES systems selected for the base-case simulations were: (1) a one-tank storage model to represent the oil/rock TES system; and (2) a two-tank storage model to represent the molten nitrate salt TES system. Results of the study clearly indicate that an engineering optimization of the TES system using TRNSYS is possible. The one-tank stratified oil/rock storage model described here is a good starting point for parametric studies of a TES system. Further developments to the TRNSYS library of available models (economizer, evaporator, gas turbine, etc.) are recommended so that the phase-change processes is accurately treated.

  18. Preliminary time-phased TWRS process model results

    International Nuclear Information System (INIS)

    This report documents the first phase of efforts to model the retrieval and processing of Hanford tank waste within the constraints of an assumed tank farm configuration. This time-phased approach simulates a first try at a retrieval sequence, the batching of waste through retrieval facilities, the batching of retrieved waste through enhanced sludge washing, the batching of liquids through pretreatment and low-level waste (LLW) vitrification, and the batching of pretreated solids through high-level waste (HLW) vitrification. The results reflect the outcome of an assumed retrieval sequence that has not been tailored with respect to accepted measures of performance. The batch data, composition variability, and final waste volume projects in this report should be regarded as tentative. Nevertheless, the results provide interesting insights into time-phased processing of the tank waste. Inspection of the composition variability, for example, suggests modifications to the retrieval sequence that will further improve the uniformity of feed to the vitrification facilities. This model will be a valuable tool for evaluating suggested retrieval sequences and establishing a time-phased processing baseline. An official recommendation on tank retrieval sequence will be made in September, 1995

  19. Preliminary time-phased TWRS process model results

    Energy Technology Data Exchange (ETDEWEB)

    Orme, R.M.

    1995-03-24

    This report documents the first phase of efforts to model the retrieval and processing of Hanford tank waste within the constraints of an assumed tank farm configuration. This time-phased approach simulates a first try at a retrieval sequence, the batching of waste through retrieval facilities, the batching of retrieved waste through enhanced sludge washing, the batching of liquids through pretreatment and low-level waste (LLW) vitrification, and the batching of pretreated solids through high-level waste (HLW) vitrification. The results reflect the outcome of an assumed retrieval sequence that has not been tailored with respect to accepted measures of performance. The batch data, composition variability, and final waste volume projects in this report should be regarded as tentative. Nevertheless, the results provide interesting insights into time-phased processing of the tank waste. Inspection of the composition variability, for example, suggests modifications to the retrieval sequence that will further improve the uniformity of feed to the vitrification facilities. This model will be a valuable tool for evaluating suggested retrieval sequences and establishing a time-phased processing baseline. An official recommendation on tank retrieval sequence will be made in September, 1995.

  20. Robot-assisted radical prostatectomy in Brazil: preliminary results

    Directory of Open Access Journals (Sweden)

    Jose Roberto Colombo Junior

    2009-12-01

    Full Text Available Purpose: To report the initial experience on robot-assisted radical prostatectomy in Brazil. Methods: From March 2008 to March 2009, a hundred patients were treated with robot-assisted radical prostatectomy. Patient’s demographic data, as well as perioperative results of the procedures, are described in this study. Rresults: Patients’ mean age and mean PSA were 58 years and 7.58 ng/ml, respectively. All procedures were performed through transperitoneal approach, with a mean bleeding of 480 mL and surgical time of 298 minutes. A surgical margin affected by cancer was present in 16% of the cases. There were four complications: bleeding requiring transfusion (two cases, rectal perforation corrected on the spot and inadequate functioning of the robot. There was no conversion to another access or obit occurrences in this caseload. Cconclusions: Robot-assisted prostatectomy is a reality in Brazil and the results herein presented demonstrate that this procedure can be safely performed. Long-term follow-up is still necessary to assess the oncological and functional outcomes.

  1. Simulating lightning into the RAMS model: implementation and preliminary results

    Directory of Open Access Journals (Sweden)

    S. Federico

    2014-05-01

    Full Text Available This paper shows the results of a tailored version of a previously published methodology, designed to simulate lightning activity, implemented into the Regional Atmospheric Modeling System (RAMS. The method gives the flash density at the resolution of the RAMS grid-scale allowing for a detailed analysis of the evolution of simulated lightning activity. The system is applied in detail to two case studies occurred over the Lazio Region, in Central Italy. Simulations are compared with the lightning activity detected by the LINET network. The cases refer to two thunderstorms of different intensity. Results show that the model predicts reasonably well both cases and that the lightning activity is well reproduced especially for the most intense case. However, there are errors in timing and positioning of the convection, whose magnitude depends on the case study, which mirrors in timing and positioning errors of the lightning distribution. To assess objectively the performance of the methodology, standard scores are presented for four additional case studies. Scores show the ability of the methodology to simulate the daily lightning activity for different spatial scales and for two different minimum thresholds of flash number density. The performance decreases at finer spatial scales and for higher thresholds. The comparison of simulated and observed lighting activity is an immediate and powerful tool to assess the model ability to reproduce the intensity and the evolution of the convection. This shows the importance of the use of computationally efficient lightning schemes, such as the one described in this paper, in forecast models.

  2. Speckle imaging with the MAMA detector: Preliminary results

    Science.gov (United States)

    Horch, E.; Heanue, J. F.; Morgan, J. S.; Timothy, J. G.

    1994-01-01

    We report on the first successful speckle imaging studies using the Stanford University speckle interferometry system, an instrument that uses a multianode microchannel array (MAMA) detector as the imaging device. The method of producing high-resolution images is based on the analysis of so-called 'near-axis' bispectral subplanes and follows the work of Lohmann et al. (1983). In order to improve the signal-to-noise ratio in the bispectrum, the frame-oversampling technique of Nakajima et al. (1989) is also employed. We present speckle imaging results of binary stars and other objects from V magnitude 5.5 to 11, and the quality of these images is studied. While the Stanford system is capable of good speckle imaging results, it is limited by the overall quantum efficiency of the current MAMA detector (which is due to the response of the photocathode at visible wavelengths and other detector properties) and by channel saturation of the microchannel plate. Both affect the signal-to-noise ratio of the power spectrum and bispectrum.

  3. Ramadan fasting: Evidence or expert opinion? Results of preliminary studies

    Directory of Open Access Journals (Sweden)

    1Maryam Kazemi

    2013-11-01

    Full Text Available Each year, over a billion Muslims fast worldwide during the month of Ramadan. Through this religious practice, not only will one have spiritual growth, but can improve his/her diet, which is of pivotal importance in this month. Conversely, the available evidence regarding the health benefits of Ramadan fasting is scarce and highly contentious. Although Islam exempts patients from fasting, many of them fast conceivably and their clinical condition is prone to deteriorate. This is due to the persistent gap between current expert knowledge and conclusive, strong evidence regarding the pathophysiologic and metabolic alterations by fasting, and the consensus that healthcare professionals should reach, in order to manage various patient groups during this month. In this review, we summarize the results of our initial studies regarding the effects of Ramadan fasting on some clinical conditions including alterations of body composition. We also go through the important clinical results of patients who have had previous history of cardiovascular disease, type 2 diabetes, asthma and renal colic. Our studies have presented some evidence in favor of Ramadan fasting and encourage those with mentioned diseases to consult their physicians and follow medical and scientific recommendations. We attempt to present some relevant evidence clarify future scopes in this area of study, and provide suggestions for future investigations.

  4. Ramadan fasting: Evidence or expert opinion? Results of preliminary studies

    Directory of Open Access Journals (Sweden)

    Maryam Kazemi

    2013-12-01

    Full Text Available Each year, over a billion Muslims fast worldwide during the month of Ramadan.  Through this religious practice, not only will one have spiritual growth, but can improve his/her diet, which is of pivotal importance in this month. Conversely, the available evidence regarding the health benefits of Ramadan fasting is scarce and highly contentious. Although Islam exempts patients from fasting, many of them fast conceivably and their clinical condition is prone to deteriorate. This is due to the persistent gap between current expert knowledge and conclusive, strong evidence regarding the pathophysiologic and metabolic alterations by fasting, and the consensus that healthcare professionals should reach, in order to manage various patient groups during this month. In this review, we summarize the results of our initial studies regarding the effects of Ramadan fasting on some clinical conditions including alterations of body composition. We also go through the important clinical results of patients who have had previous history of cardiovascular disease, type 2 diabetes, asthma and renal colic. Our studies have presented some evidence in favor of Ramadan fasting and encourage those with mentioned diseases to consult their physicians and follow medical and scientific recommendations. We attempt to present some relevant evidence clarify future scopes in this area of study, and provide suggestions for future investigations.

  5. Radiation pasteurization of poultry feed: Preliminary results of feeding tests

    International Nuclear Information System (INIS)

    Feed used to rear farm animals for human consumption has often been implicated as a vehicle for dissemination of microbial pathogens that can adversely affect both animals or birds, and humans. Radiation pasteurization of animal feed to improve its microbiological quality should reduce the incidence of feed-borne infection in the herd or flock. This would result in safer food for the consumer, and improved economic performance of the production unit. This latter benefit is particularly important because it would directly offset the cost of treating the feed. The likelihood of occurrence, as well as the magnitude, of any improved economic performance in the herd or flock consuming the irradiated feed must be determined experimentally. Accordingly, short term feeding tests were carried out to determine the effect of radiation pasteurization of poultry feed on growth performance of young chicks. The results suggest that radiation pasteurization of poultry feed may have a beneficial effect on the feed conversion efficiency of the birds consuming that feed. 10 refs, 8 tabs

  6. Preliminary Hydrogeologic Characterization Results from the Wallula Basalt Pilot Study

    Energy Technology Data Exchange (ETDEWEB)

    B.P. McGrail; E. C. Sullivan; F. A. Spane; D. H. Bacon; G. Hund; P. D. Thorne; C. J. Thompson; S. P. Reidel; F. S. Colwell

    2009-12-01

    The DOE's Big Sky Regional Carbon Sequestration Partnership has completed drilling the first continental flood basalt sequestration pilot borehole to a total depth (TD) of 4,110 feet on the Boise White Paper Mill property at Wallula, Washington. Site suitability was assessed prior to drilling by the 2007-2008 acquisition, processing and analysis of a four-mile, five-line three component seismic swath, which was processed as a single data-dense line. Analysis of the seismic survey data indicated a composite basalt formation thickness of {approx}8,000 feet and absence of major geologic structures (i.e., faults) along the line imaged by the seismic swath. Drilling of Wallula pilot borehole was initiated on January 13, 2009 and reached TD on April 6, 2009. Based on characterization results obtained during drilling, three basalt breccia zones were identified between the depth interval of 2,716 and 2,910 feet, as being suitable injection reservoir for a subsequent CO2 injection pilot study. The targeted injection reservoir lies stratigraphically below the massive Umtanum Member of the Grande Ronde Basalt, whose flow-interior section possesses regionally recognized low-permeability characteristics. The identified composite injection zone reservoir provides a unique and attractive opportunity to scientifically study the reservoir behavior of three inter-connected reservoir intervals below primary and secondary caprock confining zones. Drill cuttings, wireline geophysical logs, and 31one-inch diameter rotary sidewall cores provided geologic data for characterization of rock properties. XRF analyses of selected rock samples provided geochemical characterizations of the rocks and stratigraphic control for the basalt flows encountered by the Wallula pilot borehole. Based on the geochemical results, the pilot borehole was terminated in the Wapshilla Ridge 1 flow of the Grande Ronde Basalt Formation. Detailed hydrologic test characterizations of 12 basalt interflow

  7. Gastrointestinal transfer of neptunium (V) in newborn baboons: preliminary results

    International Nuclear Information System (INIS)

    To measure gastrointestinal neptunium absorption, baboons aged from 17 hours to 26 days were gavaged with an oral dose of 0.002 ug/kg of neptunium-239 nitrate. Absorption ranged from 3.71 to 0.113 per cent of the gavaged dose which was, 88 to 3 times higher than the values for adults. This range was reduced to 41 to 3 when doubtful results were discarded because of possible lung contamination. Absorption was expressed in terms of retention per animal at killing since collection of urine and faeces from neonates was not possible. For the same animals the skeleton/liver ratio of the neptunium burden rose continuously in the 26 dav-old baboon and reached twice the mean adult value

  8. Bioelectrical impedance analysis for bovine milk: Preliminary results

    Science.gov (United States)

    Bertemes-Filho, P.; Valicheski, R.; Pereira, R. M.; Paterno, A. S.

    2010-04-01

    This work reports the investigation and analysis of bovine milk quality by using biological impedance measurements using electrical impedance spectroscopy (EIS). The samples were distinguished by a first chemical analysis using Fourier transform midinfrared spectroscopy (FTIR) and flow citometry. A set of milk samples (100ml each) obtained from 17 different cows in lactation with and without mastitis were analyzed with the proposed technique using EIS. The samples were adulterated by adding distilled water and hydrogen peroxide in a controlled manner. FTIR spectroscopy and flow cytometry were performed, and impedance measurements were made in a frequency range from 500Hz up to 1MHz with an implemented EIS system. The system's phase shift was compensated by measuring saline solutions. It was possible to show that the results obtained with the Bioelectrical Impedance Analysis (BIA) technique may detect changes in the milk caused by mastitis and the presence of water and hydrogen peroxide in the bovine milk.

  9. SOME PRELIMINARY RESULTS FROM STUDY OF CRUSTAL DEFORMATION IN VIETNAM

    Institute of Scientific and Technical Information of China (English)

    Cao Dinh Trieu; Le Van Dung; Nguyen Huu Tuyen; Pham Nam Hung

    2003-01-01

    In this work, the authors present some results of strain monitoring within the territory of Vietnam from 1984 to 2001. Data analysis shows that (1) the Phu Lien area is tectonically stable with low strain rate, 1×10-6/a; (2) the Hoa Binh area has indication of tectonic instability with relatively high strain rate of the earth crust: absolute value of the strain reaching 100 × 10-6 , usual average strain amplitude of 60 × 10-6 , whereas the monthly average strain intensity varies in a range from 30× 10-6 to 50× 10-6 (3) there are clear indications of the strain state of the earth crust before occurrence of earthquakes of medium or higher magnitude. This is a very important indication in the research and short-term prediction of earthquakes, especially for the areas with low seismic stability like the NW of Vietnam.

  10. Preliminary Results of Testing of Flow Effects on Evaporator Scaling

    Energy Technology Data Exchange (ETDEWEB)

    Hu, M.Z.

    2002-02-15

    This investigation has focused on the effects of fluid flow on solids deposition from solutions that simulate the feed to the 2H evaporator at the Savannah River Site. Literature studies indicate that the fluid flow (or shear) affects particle-particle and particle-surface interactions and thus the phenomena of particle aggregation in solution and particle deposition (i.e., scale formation) onto solid surfaces. Experimental tests were conducted with two configurations: (1) using a rheometer to provide controlled shear conditions and (2) using controlled flow of reactive solution through samples of stainless steel tubing. All tests were conducted at 80 C and at high silicon and aluminum concentrations, 0.133 M each, in solutions containing 4 M sodium hydroxide and 1 A4 each of sodium nitrate and sodium nitrite. Two findings from these experiments are important for consideration in developing approaches for reducing or eliminating evaporator scaling problems: (1) The rheometer tests suggested that for the conditions studied, maximum solids deposition occurs at a moderate shear rate, approximately 12 s{sup -1}. That value is expected to be on the order of shear rates that will occur in various parts of the evaporator system; for instance, a 6 gal/min single-phase liquid flow through the 2-in. lift or gravity drain lines would result in a shear rate of approximately 16 s{sup -1}. These results imply that engineering approaches aimed at reducing deposits through increased mixing would need to generate shear near all surfaces significantly greater than 12 s{sup -1}. However, further testing is needed to set a target value for shear that is applicable to evaporator operation. This is because the measured trend is not statistically significant at the 95% confidence interval due to variability in the results. In addition, testing at higher temperatures and lower concentrations of aluminum and silicon would more accurately represent conditions in the evaporator. Without

  11. Preliminary results on scintigraphic evaluation of malignant external otitis

    International Nuclear Information System (INIS)

    Malignant external otitis (MEO) is a potentially fatal otitis occurring in diabetic and immunosuppressed patients, which may cause cranial nerve palsies and massive thrombophlebitis of the brain. We studied five diabetic patients with the clinical diagnosis of external otitis who were suspected of having MEO and one diabetic patient presumed cured from MEO. All of them underwent methylene diphosphonate, nanocolloid and gallium single-photon emission tomography studies with quantitative analysis on the basis of regions of interest and count profile curves. This combined assessment helped us to diagnose and follow-up soft tissue and temporal bone infection, especially in the case of transsphenoidal extension of the disease, since conventional radiology and computed tomography were of no particular help. On the basis of these results, we consider scintigraphic demonstration of skull base infection as a fourth criterion of MEO given that the classical Chandler's triad (diabetes, granuloma, and Pseudomonas aeruginosa) is not always present. (orig.)

  12. Bioenergy potentials from forestry to 2050. Preliminary results

    International Nuclear Information System (INIS)

    In this study a bottom-up scenario analysis of the global bioenergy production potential is carried out, with specific attention for the impact of underlying factors, existing outlook studies on demand and supply and gaps in the knowledge base that explain the large range in estimates. Key variables are the demand for industrial roundwood and fuelwood, plantation establishment rates and natural forest growth. Key uncertainties are the supply of wood from trees outside and the impact of sustainable forest management (SFM) of yields. Results show that the world is capable of meeting the future demand for industrial roundwood and fuelwood, without further deforestation. The total potential of bioenergy from surplus forest growth and residues is estimated at 27 to 140 EJy-1 in 2050

  13. Preliminary results from the MAMA detectors for the SOHO mission

    Science.gov (United States)

    Slater, David C.; Bergamini, Paolo; Bumala, Robert W.; Timothy, J. G.

    1993-01-01

    Multi-Anode Microchannel Array (MAMA) detector systems are being fabricated and tested for use in the Solar Ultraviolet Measurements of Emitted Radiation (SUMER) and the Ultraviolet Coronagraph Spectrometer (UVCS) instruments on the ESA/NASA Solar and Heliospheric Observatory (SOHO) mission. The SOHO MAMA detector systems have formats of 360 x 1024 pixels and pixel dimensions of 25 x 25 sq microns and are optimized for operation at Extreme Ultraviolet (EUV) wavelengths between 40 and 160 nm. In this paper we report on the initial results of measurements of the performance characteristics of the first flight-configuration detector system employing the new custom Application Specific Integrated Circuits (ASICs) which are designed to improve both the dynamic range and the uniformity of response. The performance characteristics of this detector system are compared with those of earlier breadboard systems employing discrete-component electronics circuits.

  14. Automated Optical Meteor Fluxes and Preliminary Results of Major Showers

    Science.gov (United States)

    Blaauw, R.; Campbell-Brown, M.; Cooke, W.; Kingery, A.; Weryk, R.; Gill, J.

    2014-01-01

    NASA's Meteoroid Environment Office (MEO) recently established a two-station system to calculate daily automated meteor fluxes in the millimeter-size-range for both single-station and double-station meteors. The cameras each consist of a 17 mm focal length Schneider lens (f/0.95) on a Watec 902H2 Ultimate CCD video camera, producing a 21.7x15.5 degree field of view. This configuration sees meteors down to a magnitude of +6. This paper outlines the concepts of the system, the hardware and software, and results of 3,000+ orbits from the first 18 months of operations. Video from the cameras are run through ASGARD (All Sky and Guided Automatic Real-time Detection), which performs the meteor detection/photometry, and invokes MILIG and MORB (Borovicka 1990) codes to determine the trajectory, speed, and orbit of the meteor. A subroutine in ASGARD allows for approximate shower identification in single-station detections. The ASGARD output is used in routines to calculate the flux. Before a flux can be calculated, a weather algorithm indicates if sky conditions are clear enough to calculate fluxes, at which point a limiting magnitude algorithm is employed. The limiting stellar magnitude is found using astrometry.net (Lang et al. 2012) to identify stars and translated to the corresponding shower and sporadic limiting meteor magnitude. It is found every 10 minutes and is able to react to quickly changing sky conditions. The extensive testing of these results on the Geminids and Eta Aquariids is shown. The flux involves dividing the number of meteors by the collecting area of the system, over the time interval for which that collecting area is valid. The flux algorithm employed here differs from others currently in use in that it does not make the gross oversimplication of choosing a single height to calculate the collection area of the system. In the MEO system, the volume is broken up into a set of height intervals, with the collecting areas determined by the position of the

  15. 3D inversion of lunar gravity data and preliminary results

    Science.gov (United States)

    Liang, Q.; Chen, C.; Li, Y.

    2010-12-01

    Gravity anomaly tells how the subsurface density varies or where the mass concentrations are located at. Inversion of gravity data gives a way to directly recover the density distributions. It has been demonstrated that the inversion is capable of retrieving density structures in resources exploration on the Earth. With increasing interests in interior structures of the Moon, scientists have obtained its gravity field with improved resolution on the lunar far side. We may thus utilize the inverse method to recover the lunar density structures beneath mascon basins or the density inhomogeneities in the crust and mantle. However, if considering the spherical gravity data in global scale, there are limitations in the previous inversion because the methods were based on the Cartesian coordinates system. In order to solve the problems, we developed a new 3D inverse method with three aspects involved: 1) A new model objective function adaptive to spherical coordinate system was established in the light of the Backus-Gilbert model appraisal theory. 2) A depth weighting function in inversion was also developed to approximately compensate for the kernel’s natural decay in potential field. And, 3) Non-uniqueness was suppressed by using model constraints and Tikhonov regularization tool. With the above developments and techniques, our method can quantitatively interpret the spherical gravity data. We firstly performed the inversion of synthetic data and confirmed that the locations of anomaly bodies were well defined, and then applied this method to the Bouguer gravity anomaly of the Moon which has been previously calculated based on the Chang'E-1 topography data and the SELENE gravity field model. Results showed that, on the one hand, the positive density anomalies beneath the mascon basins concentrated at the depth of 20-50km. Their residual densities are larger than 0.3g/cm^3 close to the density difference between lunar mantle and crust. Density structures along radial

  16. The ABC Schizophrenia Study: a preliminary overview of the results.

    Science.gov (United States)

    Häfner, H; Maurer, K; Löffler, W; an der Heiden, W; Munk-Jørgensen, P; Hambrecht, M; Riecher-Rössler, A

    1998-08-01

    The ABC Schizophrenia Study, a large-scale epidemiological and neurobiological research project commenced in 1987, initially pursued two aims: (1) to elucidate the possible causes of the sex difference in age at first admission for schizophrenia and (2) to analyse the early course of the disorder from onset until first contact and its implications for further course and outcome. First, transnational case-register data (for Denmark and Germany) were compared, second, a population-based sample of first-episode cases of schizophrenia (n = 232) were selected and third, the results obtained were compared with data from the WHO Determinants of Outcome Study by using a systematic methodology. A consistent result was a 3-4 years higher age of onset for women by any definition of onset, which was not explainable by social variables, such as differences in the male-female societal roles. A sensitivity-reducing effect of oestrogen on central D2 receptors was identified as the underlying neurobiological mechanism in animal experiments. Applicability to humans with schizophrenia was established in a controlled clinical study. A comparison of familial and sporadic cases showed that in cases with a high genetic load, the sex difference in age of onset disappeared due to a clearly reduced age of onset in women, whereas in sporadic cases it increased. To analyse early course retrospectively, a semistructured interview, IRAOS, was developed. The early stages of the disorder were reconstructed in comparison with age- and sex-matched controls from the same population of origin. The initial signs consisted mainly of negative and affective symptoms, which accumulated exponentially until the first episode, as did the later emerging positive symptoms. Social disability appeared 2-4 years before first admission on average. In early-onset cases, social course and outcome, studied prospectively over 5 years, was determined by the level of social development at onset through social stagnation

  17. Radiation therapy for macular degeneration: technical considerations and preliminary results

    International Nuclear Information System (INIS)

    Purpose: This study was undertaken to assess the toxicity and possible benefits from the administration of low-dose external-beam irradiation for Age-Related Macular Degeneration (ARMD). The premise of the treatment is that radiation induces regression and/or promotes inactivation of the subretinal neo-vasculature, resulting in reabsorption of fluid and blood thus reducing the risk for further leakage or bleeding, as well as subretinal fibrosis. Clinically, the beneficial effect could be translated into stabilization of visual acuity and prevention of progression of the wet type of ARMD with the possibility for some visual improvement. Methods and Materials: Allegheny University Hospitals, Hahnemann, Department of Radiation Oncology, treated 278 patients prospectively beginning in January 1995 with low-dose irradiation for wet-type macular degeneration. Two hundred forty-nine patients were treated with a total dose of 14.40 Gy in eight fractions of 1.80 Gy over 10-13 elapsed days, and 27 patients with 20 Gy at 2 Gy per fraction over 12-15 days. The first two patients were treated to a total dose of 10.00 Gy in five fractions of 2.00 Gy. Patients were evaluated at 2-3 weeks and 2-3 months. A percentage (36.7%) of the patients had previously received laser treatments in the study eye, 21.9% once, 5% twice, 9.7% three or more. Subjective visual acuity and toxicity data was collected on all patients. Results: At 2-3 weeks after treatment 195 patients (70%) retained their visual acuity without change, 68 patients (24.5%) stated they had improved vision, and 15 patients (4.8%) stated their vision continued to decrease. Two to 3 months after treatment, 183 patients (65.8%) had no change in their vision. 75 patients (27%) patients had an improvement in their vision, and 20 patients (7.2%) had a decrease in visual acuity. Transient acute reactions occurred in 14 of the 278 patients treated. Conclusion: Our observations in this group of 278 patients support the conclusion

  18. Magnetic field studies at jupiter by voyager 2: preliminary results.

    Science.gov (United States)

    Ness, N F; Acuna, M H; Lepping, R P; Burlaga, L F; Behannon, K W; Neubauer, F M

    1979-11-23

    Data from the Goddard Space Flight Center magnetometers on Voyager 2 have yielded on inbound trajectory observations of multiple crossings of the bow shock and magnetosphere near the Jupiter-sun line at radial distances of 99 to 66 Jupiter radii (RJ) and 72 to 62 RJ, respectively. While outbound at a local hour angle of 0300, these distances increase appreciably so that at the time of writing only the magnetopause has been observed between 160 and 185 RJ. These results and the magnetic field geometry confirm the earlier conclusion from Voyager I studies that Jupiter has an enormous magnetic tail, approximately 300 to 400 RJ in diameter, trailing behind the planet with respect to the supersonic flow of the solar wind. Addi- tional observations of the distortion of the inner magnetosphere by a concentrated plasma show a spatial merging of the equatorial magnetodisk current with the cur- rent sheet in the magnetic tail. The spacecraft passed within 62,000 kilometers of Ganymede (radius = 2,635 kilometers) and observed characteristic fluctuations in- terpreted tentatively as being due to disturbances arising from the interaction of the Jovian magnetosphere with Ganymede. PMID:17733916

  19. Preliminary results from the heavy ions in space experiment

    Science.gov (United States)

    Adams, James H., Jr.; Beahm, Lorraine P.; Tylka, Allan J.

    1992-01-01

    The Heavy Ions In Space (HIIS) experiment has two primary objectives: (1) to measure the elemental composition of ultraheavy galactic cosmic rays, beginning in the tin-barium region of the periodic table; and (2) to study heavy ions which arrive at LDEF below the geomagnetic cutoff, either because they are not fully stripped of electrons or because their source is within the magnetosphere. Both of these objectives have practical as well as astrophysical consequences. In particular, the high atomic number of the ultraheavy galactic cosmic rays puts them among the most intensely ionizing particles in Nature. They are therefore capable of upsetting electronic components normally considered immune to such effects. The below cutoff heavy ions are intensely ionizing because of their low velocity. They can be a significant source of microelectronic anomalies in low inclination orbits, where Earth's magnetic field protects satellites from most particles from interplanetary space. The HIIS results will lead to significantly improved estimates of the intensely ionizing radiation environment.

  20. Eight Pulse Performance of DARHT Axis II - Preliminary Results

    Energy Technology Data Exchange (ETDEWEB)

    Schulze, Martin E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-12-08

    The DARHT-II accelerator produces a 1.65-kA, 17-MeV beam in a 1600-ns pulse. Standard operation of the DARHT Axis II accelerator involves extracting four short pulses from the 1.6 us long macro-pulse produced by the LIA. The four short pulses are extracted using a fast kicker in combination with a quadrupole septum magnet and then transported for several meters to a high-Z material target for conversion to x-rays for radiography. The ability of the DARHT Axis 2 kicker to produce more than the standard four pulse format has been previously demonstrated. This capability was developed to study potential risks associated with beam transport during an initial commissioning phase at low energy (8 MeV) and low current (1.0 kA).The ability of the kicker to deliver more than four pulses to the target has been realized for many years. This note describes the initial results demonstrating this capability.

  1. Leaching in the material balance of peatlands - preliminary results

    International Nuclear Information System (INIS)

    The hydrology and hydrochemistry of Lakkasuo (Orivesi, central Finland) was studied for a 12 month period (Sep. 1991 - Aug. 1992). Results from four monitored catchments in Lakkasuo are presented. The catchments represent a bog and a fen, both in the natural stage and as drained for forestry 30 years ago. In the relatively wet study period (runoff 414 mm for the undrained bog), the catchments released 8.0-16.6 g/m2 of organic carbon (mainly dissolved) into runoff waters. All the catchments retained total N and sulfate provided by deposition or groundwater very effectively (65-80 % and 52-72 %, respectively); undrained catchments retained also total P. The net output rates of all the elements except H+ were greater from the drained catchments compared with the undrained ones. The leaching rates of Mg and Ca from the drained catchments were greater compared with the pool of these elements in the surface peat, whereas the K pool is more effectively retained and added to by deposition

  2. Preliminary results on isotopic methods for the control of wines

    International Nuclear Information System (INIS)

    Full text: Isotopic methods have shown to be a major tool for checking the compliance of food products and beverages with national and international regulations. This paper presents some results on isotopic methods for control of wines. We developed a method for determining 13C/12C and 18O/16O isotope ratios in wine's ethanol and water. These ratios are significantly influenced by geo-climatic conditions of the origin region of wine, the type of plant (species or subspecies), and the year of harvest. The determination of 13C/12C ratio of wine ethanol was performed in three steps: (I) 500 ml of a wine sample was distilled at constant reflux ratio, (10). The distillate was collected with an ethanol content of about 93 % (mass), without significant isotope fractionation; (II) The ethanol was converted into CO2 by combustion in excess of oxygen; (III) The carbon isotope ratio of CO2 was analyzed using the isotope ratio mass spectrometry (IRMS). The 18O/16O ratio of the wine water was determined by IRMS using CO2 obtained after equilibration of wine with carbon dioxide. We developed this method in order to get a data bank of isotope ratios for authentic samples of wine as well as for the routine control of many marketed wines. (authors)

  3. Light propagation in inhomogeneous universes. I. Methodology and preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Premadi, Premana; Matzner, Richard [Center for Relativity and Department of Physics, University of Texas, Austin, Texas78712 (United States)] Martel, Hugo [Department of Astronomy, University of Texas, Austin, Texas 78712 (United States)] Matzner, Richard [Orson Anderson Scholar, Los Alamos National Laboratory, 1996--1997 (United States)

    1998-01-01

    We describe a numerical algorithm that simulates the propagation of light in inhomogeneous universes. This algorithm computes the trajectories of light rays between the observer, located at redshift z=0, and distant sources located at high redshift using the multiple lens plane method. The deformation and deflection of light beams as they interact with each lens plane are computed using the filled-beam approximation. We use a particle-particle/particle-mesh (P{sup 3}M) N-body numerical code to simulate the formation of large-scale structure in the universe. We extend the length resolution of the simulations to sub-megaparsec scales by using a Monte Carlo method for locating galaxies inside the computational volume according to the underlying distribution of background matter. The observed galaxy two-point correlation function is reproduced. This algorithm constitutes a major improvement over previous methods, which either neglected the presence of large-scale structure, neglected the presence of galaxies, neglected the contribution of distant matter (matter located far from the beam), or used the Zeldovich approximation for simulating the formation of large-scale structure. In addition, we take into account the observed morphology-density relation when assigning morphological types to galaxies, something that was ignored in all previous studies. To test this algorithm, we perform 1981 simulations for three different cosmological models: an Einstein-de Sitter model with density parameter {Omega}{sub 0}=1, an open model with {Omega}{sub 0}=0.2, and a flat, low-density model with {Omega}{sub 0}=0.2 and a cosmological constant of {lambda}{sub 0}=0.8. In all models, the initial density fluctuations correspond to a cold dark matter power spectrum normalized to {ital COBE}. In each simulation, we compute the shear and magnification resulting from the presence of inhomogeneities. Our results are the following: (1) The magnification is totally dominated by the convergence

  4. Preliminary results on noncollocated torque control of space robot actuators

    Science.gov (United States)

    Tilley, Scott W.; Francis, Colin M.; Emerick, Ken; Hollars, Michael G.

    1989-01-01

    In the Space Station era, more operations will be performed robotically in space in the areas of servicing, assembly, and experiment tending among others. These robots may have various sets of requirements for accuracy, speed, and force generation, but there will be design constraints such as size, mass, and power dissipation limits. For actuation, a leading motor candidate is a dc brushless type, and there are numerous potential drive trains each with its own advantages and disadvantages. This experiment uses a harmonic drive and addresses some inherent limitations, namely its backdriveability and low frequency structural resonances. These effects are controlled and diminished by instrumenting the actuator system with a torque transducer on the output shaft. This noncollocated loop is closed to ensure that the commanded torque is accurately delivered to the manipulator link. The actuator system is modelled and its essential parameters identified. The nonlinear model for simulations will include inertias, gearing, stiction, flexibility, and the effects of output load variations. A linear model is extracted and used for designing the noncollocated torque and position feedback loops. These loops are simulated with the structural frequency encountered in the testbed system. Simulation results are given for various commands in position. The use of torque feedback is demonstrated to yield superior performance in settling time and positioning accuracy. An experimental setup being finished consists of a bench mounted motor and harmonic drive actuator system. A torque transducer and two position encoders, each with sufficient resolution and bandwidth, will provide sensory information. Parameters of the physical system are being identified and matched to analytical predictions. Initial feedback control laws will be incorporated in the bench test equipment and various experiments run to validate the designs. The status of these experiments is given.

  5. Thermal plasma treatment of cell-phone waste : preliminary result

    Energy Technology Data Exchange (ETDEWEB)

    Ruj, B. [Central Mechanical Engineering Research Inst., Durgapur (India). Thermal Engineering Group; Chang, J.S.; Li, O.L. [McMaster Univ., Hamilton, ON (Canada). Dept. of Engineering Physics; Pietsch, G. [RWTH Aachen Univ., Aachen (Germany)

    2010-07-01

    The cell phone is an indispensable service facilitator, however, the disposal and recycling of cell phones is a major problem. While the potential life span of a mobile phone, excluding batteries, is over 10 years, most of the users upgrade their phones approximately four times during this period. Cell phone waste is significantly more hazardous than many other municipal wastes as it contains thousands of components made of toxic chemicals and metals like lead, cadmium, chromium, mercury, polyvinyl chlorides (PVC), brominated flame retardants, beryllium, antimony and phthalates. Cell phones also use many expensive rare metals. Since cell phones are made up of plastics, metals, ceramics, and trace other substances, primitive recycling or disposal of cell phone waste to landfills and incinerators creates irreversible environmental damage by polluting water and soil, and contaminating air. In order to minimize releases into the environment and threat to human health, the disposal of cell phones needs to be managed in an environmentally friendly way. This paper discussed a safer method of reducing the generation of syngas and hydrocarbons and metal recovery through the treatment of cell phone wastes by a thermal plasma. The presentation discussed the experiment, with particular reference to sample preparation; experimental set-up; and results four samples with different experimental conditions. It was concluded that the plasma treatment of cell phone waste in reduced condition generates gaseous components such as hydrogen, carbon monoxide, and hydrocarbons which are combustible. Therefore, this system is an energy recovery system that contributes to resource conservation and reduction of climate change gases. 5 refs., 2 tabs., 2 figs.

  6. The HCV Synthesis Project: Scope, methodology, and preliminary results

    Directory of Open Access Journals (Sweden)

    Scheinmann Roberta

    2008-09-01

    Full Text Available Abstract Background The hepatitis C virus (HCV is hyper-endemic in injecting drug users. There is also excess HCV among non-injection drug users who smoke, snort, or sniff heroin, cocaine, crack, or methamphetamine. Methods To summarize the research literature on HCV in drug users and identify gaps in knowledge, we conducted a synthesis of the relevant research carried out between 1989 and 2006. Using rigorous search methods, we identified and extracted data from published and unpublished reports of HCV among drug users. We designed a quality assurance system to ensure accuracy and consistency in all phases of the project. We also created a set of items to assess study design quality in each of the reports we included. Results We identified 629 reports containing HCV prevalence rates, incidence rates and/or genotype distribution among injecting or non-injecting drug user populations published between January 1989 and December 2006. The majority of reports were from Western Europe (41%, North America (26%, Asia (11% and Australia/New Zealand (10%. We also identified reports from Eastern Europe, South America, the Middle East, and the Caribbean. The number of publications reporting HCV rates in drug users increased dramatically between 1989 and 2006 to 27–52 reports per year after 1998. Conclusion The data collection and quality assurance phases of the HCV Synthesis Project have been completed. Recommendations for future research on HCV in drug users have come out of our data collection phase. Future research reports can enhance their contributions to our understanding of HCV etiology by clearly defining their drug user participants with respect to type of drug and route of administration. Further, the use of standard reporting methods for risk factors would enable data to be combined across a larger set of studies; this is especially important for HCV seroconversion studies which suffer from small sample sizes and low power to examine risk

  7. Flight Test 4 Preliminary Results: NASA Ames SSI

    Science.gov (United States)

    Isaacson, Doug; Gong, Chester; Reardon, Scott; Santiago, Confesor

    2016-01-01

    Realization of the expected proliferation of Unmanned Aircraft System (UAS) operations in the National Airspace System (NAS) depends on the development and validation of performance standards for UAS Detect and Avoid (DAA) Systems. The RTCA Special Committee 228 is charged with leading the development of draft Minimum Operational Performance Standards (MOPS) for UAS DAA Systems. NASA, as a participating member of RTCA SC-228 is committed to supporting the development and validation of draft requirements as well as the safety substantiation and end-to-end assessment of DAA system performance. The Unmanned Aircraft System (UAS) Integration into the National Airspace System (NAS) Project conducted flight test program, referred to as Flight Test 4, at Armstrong Flight Research Center from April -June 2016. Part of the test flights were dedicated to the NASA Ames-developed Detect and Avoid (DAA) System referred to as JADEM (Java Architecture for DAA Extensibility and Modeling). The encounter scenarios, which involved NASA's Ikhana UAS and a manned intruder aircraft, were designed to collect data on DAA system performance in real-world conditions and uncertainties with four different surveillance sensor systems. Flight test 4 has four objectives: (1) validate DAA requirements in stressing cases that drive MOPS requirements, including: high-speed cooperative intruder, low-speed non-cooperative intruder, high vertical closure rate encounter, and Mode CS-only intruder (i.e. without ADS-B), (2) validate TCASDAA alerting and guidance interoperability concept in the presence of realistic sensor, tracking and navigational errors and in multiple-intruder encounters against both cooperative and non-cooperative intruders, (3) validate Well Clear Recovery guidance in the presence of realistic sensor, tracking and navigational errors, and (4) validate DAA alerting and guidance requirements in the presence of realistic sensor, tracking and navigational errors. The results will be

  8. The Hyperspectral Thermal Emission Spectrometer (HyTES): Preliminary Results

    Science.gov (United States)

    Hook, Simon; Johnson, William R.; Eng, Bjorn T.; Gunapala, Sarah D.; Lamborn, Andrew U.; Mouroulis, Pantazis, Z.; Mouroulis, Pantazis, Z.; Paine, Christopher G.; Soibel, Alexander; Wilson, Daniel W.

    2011-01-01

    The Hyperspectral Thermal Emission Spectrometer (HyTES) is being developed as part of the risk reduction activities associated with the Hyperspectral Infrared Imager (HyspIRI). HyspIRI is one of the Tier 2 Decadal Survey Missions. HyTES will provide information on how to place the filters on the HyspIRI Thermal Infrared Instrument (TIR) as well as provide antecedent science data. The pushbroom design has 512 spatial pixels over a 50-degree field of view and 256 spectral channels between 7.5 micrometers to 12 micrometers. HyTES includes many key enabling state-of-the-art technologies including a high performance convex diffraction grating, a quantum well infrared photodetector (QWIP) focal plane array, and a compact Dyson-inspired optical design. The Dyson optical design allows for a very compact and optically fast system (F/1.6). It also minimizes cooling requirements due to the fact it has a single monolithic prism-like grating design which allows baffling for stray light suppression. The monolithic configuration eases mechanical tolerancing requirements which are a concern since the complete optical assembly is operated at cryogenic temperatures ((is) approximately 100K). The QWIP allows for optimum spatial and spectral uniformity and provides adequate responsivity or D-star to allow 200mK noise equivalent temperature difference (NEDT) operation across the LWIR passband. Assembly of the system is nearly complete. After completion, alignment results will be presented which show low keystone and smile distortion. This is required to minimize spatial-spectral mixing between adjacent spectral channels and spatial positions. Predictions show the system will have adequate signal to noise for laboratory calibration targets.

  9. Elaboration of a chemical decontamination technology: preliminary results

    International Nuclear Information System (INIS)

    background and knowledge evolved at Paks NPP in the course of the chemical decontamination. As a consequence of the long-established achievements, it is practical to develop a procedure based on the methodology of the AP-CITROX (or CORD) technology. It should, however, be noted that the comprehensive analysis of the risk factors, which may be emerged during the application of oxalic acid is unavoidable. In this talk, we will present a brief overview on the fundamental issues of the R and D project focused on the elaboration of the required technology and - based on the results of some recent studies in the fields of solution chemistry, electrochemistry and surface science - summarize the main characteristics of an optimal decontamination procedure. (author)

  10. Quaternary sedimentation and active faulting along the Ecuadorian shelf : preliminary results of the ATACAMES Cruise (2012)

    OpenAIRE

    Michaud, François; Proust, J. N.; Collot, Jean-Yves; Lebrun, J.F.; De Witt, C.; Ratzov, G.; H. Pouderoux; Martillo, C.; Hernandez, M.J.; Loayza, G.; Penafiel, L.; Schenini, Laure; Dano, A.; Gonzalez, M; Barba, D

    2015-01-01

    Selected high-resolution seismic-reflection profiles and multibeam bathymetry acquired along the convergent Ecuador margin during the ATACAMES cruise on onboard the R/V L'Atalante (Jan.15-Feb.18, 2012) allow a preliminary evaluation of the neotectonic development and stratigraphic evolution of the margin based on the sismo-stratigraphic analysis of Quaternary sediment preserved on the margin shelf and upper slope. We present three major preliminary results. (1) The evolution of the Esmeraldas...

  11. EM techniques for archaeological laboratory experiments: preliminary results

    Science.gov (United States)

    Capozzoli, Luigi; De Martino, Gregory; Giampaolo, Valeria; Raffaele, Luongo; Perciante, Felice; Rizzo, Enzo

    2015-04-01

    model. The integration of electric and electromagnetic data allowed us to overcome the limits of each technique, especially in terms of resolution and depth, in humid/saturated conditions was investigated and the effectiveness of three-dimensional acquisitions was studied to better explore archeological sites and reduce the uncertainties related on the interpretation of geophysical analysis. The complexity of the relationship between archaeological features in the subsoil and their geophysical response requires efforts in the interpretation of resulting data. Reference Campana S. and Piro, S., (2009): Seeing the unseen - Geophysics and landscape archaeology., CRC Press, London, 2. No. of pages: 376. ISBN: 978-0-415-44721-8. Conyers, L. and Goodman, D., (1997): Ground-Penetrating Radar: An Introduction for Archaeologists. Walnut Creek, Calif.: AltaMira Press. Davis, J.L. and Annan, A.P. (1989): Ground-penetrating radar for high-resolution mapping of soil and rock stratigraphy. Geophysical Prospecting, 37, 531-551.

  12. Dating of polyhalite and langbeinite: preliminary results from German Zechstein

    Science.gov (United States)

    Neubauer, Franz; Schorn, Anja; Leitner, Christoph; Genser, Johann

    2013-04-01

    formation temperatures are given between 57.1 ° C or more commonly 83 ° C (e.g. Neitzel, 1992 and references therein), is mined as potash ore at the German Zechstein deposits. Neitzel (1992) summarized two main types of langbeinite formation (1) from kainite and halite (due to thermal metamorphism) and (2) from sylvinitic Hartsalz (= mixture of sylvite, kieserite and halite) due to solution metamorphism. The mineral might also form by decomposition of polyhalite to langbeinite and anhydrite during prograde metamorphism. In the following, we discuss the first successful results of polyhalite and langbeinite dating in Zechstein salts of Germany (Morsleben, Neuhof). Extremely fine-grained (grain sizes International Journal of Earth Sciences, DOI 10.1007/s00531-012-0836-6. Neitzel, U., 1992. 100 Jahre Langbeinit. Kali und Steinsalz, 11/1, 7-13. Renne, P. R., Sharp, W. D. Montañez, I. P., Becker, R. A., Zierenberg, R. A., 2001. 40Ar/39Ar dating of Late Permian evaporites, southeastern New Mexico, USA. Earth and Planetary Science Letters, 193, 539-547. Warren, J. K., 2006. Evaporites: Sediments, Resources and Hydrocarbons. Springer, Berlin Heidelberg, 1035 p. Wollmann, G., 2010. Crystallization Fields of Polyhalite and its Heavy Metal Analogues. Ph.D. thesis, University Bergakademie Freiberg. Wollmann, G., Freyer, D., Voigt, W., 2008. Polyhalite and its analogous triple salts. Monatshefte für Chemie, 139, 739-745.

  13. Pulsed dose rate brachytherapy as the sole adjuvant radiotherapy after breast-conserving surgery of T1-T2 breast cancer: First long time results from a clinical study

    International Nuclear Information System (INIS)

    Background and purpose: To evaluate the long time outcome with regard to local tumour control, cosmetic outcome and side effects of a short (5 days) accelerated interstitial brachytherapy treatment delivered to the surroundings of the operated sector. Patients and methods: Between 1993 and 2003 we treated 50 women with early T1 and T2 breast cancer. Radical sector resection was performed and followed later with an interstitial pulsed dose rate (PDR) brachytherapy of 50 Gy in 5 days. The treatment was centred on the tumour with a margin of 30 mm. One patient was treated bilaterally. The patients were followed for a median of 86 (32-126) months. Results: Ipsilateral breast cancer recurrence was seen in 3 patients (6%). Two of them occurred outside the treated volume. The 5- and 7-year rates of actuarial local control were 96% and 96%, respectively, overall survival 88% and 85%, disease free survival 88% and 88%, respectively. A dosimetrical analysis showed that the partial breast irradiation covered a median of 31% of the total breast volume. Fat necrosis was seen in 12% and local (moderate-strong) fibrosis in 26% of the patients. Independent cosmetic scoring showed good or excellent result in 56% of the patients. Conclusions: Local outcome is favourable and very similar to other published studies of accelerated partial breast irradiation. Our long time cosmetic results are lower than other published results

  14. Brachytherapy on treatment of childhood rhabdomyosarcoma

    International Nuclear Information System (INIS)

    complications. Late effects were observed on head and neck patients and included facial deformity and discromies in five of seven patients. The incidence and the intensity of late effects were low in patients with extremities and genital tumors. The results confirm the value of brachytherapy on treatment of childhood rhabdomyosarcoma with high local control rates and acceptable morbidity. The brachytherapy technique employed depend of the site and volume of the tumor. It can not be established a specific one to each clinical situation

  15. Caudal epidural anesthesia during intracavitary brachytherapy for cervical cancer

    International Nuclear Information System (INIS)

    It has been suggested that pain control during intracavitary brachytherapy for cervical cancer is insufficient in most hospitals in Japan. Our hospital began using caudal epidural anesthesia during high-dose-rate (HDR) intracavitary brachytherapy in 2011. The purpose of the present study was to retrospectively investigate the effects of caudal epidural anesthesia during HDR intracavitary brachytherapy for cervical cancer patients. Caudal epidural anesthesia for 34 cervical cancer patients was performed during HDR intracavitary brachytherapy between October 2011 and August 2013. We used the patients' self-reported Numeric Rating Scale (NRS) score at the first session of HDR intracavitary brachytherapy as a subjective evaluation of pain. We compared NRS scores of the patients with anesthesia with those of 30 patients who underwent HDR intracavitary brachytherapy without sacral epidural anesthesia at our hospital between May 2010 and August 2011. Caudal epidural anesthesia succeeded in 33 patients (97%), and the NRS score was recorded in 30 patients. The mean NRS score of the anesthesia group was 5.17 ± 2.97, significantly lower than that of the control group's 6.80 ± 2.59 (P = 0.035). The caudal epidural block resulted in no side-effects. Caudal epidural anesthesia is an effective and safe anesthesia option during HDR intracavitary brachytherapy for cervical cancer. (author)

  16. Radiation Protection in Brachytherapy in the Next Decade

    International Nuclear Information System (INIS)

    Brachytherapy procedures are increasing in number, and account for an important share of radiation exposure in medicine at a time when there is a dramatic rise in cancer across the developing world. Important areas in relation to radiation safety in brachytherapy include that all efforts be made to ensure that protection in the treatment is optimized and all measures are taken to prevent accidental exposures from occurring. Historical and ongoing accidents that have resulted in patient and public doses or inappropriate medical outcomes represent opportunities for continuous improvement in radiation protection. Additionally, staff in brachytherapy treatment facilities may receive high radiation doses if radiological protection tools are not used properly. Brachytherapy uniquely presents the possibility for doses that require active management. In modern brachytherapy centres, radiation doses are incurred by staff (e.g. loading of seeds, plaques, caesium implants, associated fluoroscopy). There is also a large variation in the practice of brachytherapy on a global scale and several facilities still practise older techniques with significantly higher staff dose potential. In addition, technological developments and newer techniques present new radiation protection concerns and an increasing blurring of historical responsibilities that need to be addressed with specific recommendations for the practising medical community. Along with an increase in equipment and to safeguard resources, additional qualified and trained brachytherapy staff are required worldwide. (author)

  17. The dosimetry of brachytherapy-induced erectile dysfunction

    International Nuclear Information System (INIS)

    There is emerging evidence that brachytherapy-induced erectile dysfunction (ED) is technique-related and may be minimized by careful attention to source placement. Herein, we review the relationship between radiation doses to the prostate gland/surrounding structures and the development of brachytherapy-induced ED. The permanent prostate brachytherapy literature was reviewed using MEDLINE searches to ensure completeness. Although the site-specific structure associated with brachytherapy-induced ED remains unknown, there is an increasing body of data implicating the proximal penis. With day 0 CT-based dosimetry, the dose to 50% (D50) and 25% (D25) of the bulb of the penis should be maintained below 40% and 60% mPD, respectively, while the crura D50 should be maintained below 28% mPD to maximize post-brachytherapy potency. To date, there is no data to suggest that either radiation doses to the neurovascular bundles or choice of isotope is associated with brachytherapy-induced ED, while conflicting data has been reported regarding radiation dose to the prostate and the use of supplemental external beam radiation therapy. Although the etiology of brachytherapy-induced ED is likely multifactorial, the available data supports the proximal penis as an important site-specific structure. Refinements in implant technique, including preplanning and intraoperative seed placement, will result in lower radiation doses to the proximal penis with potential improvement in potency preservation

  18. Iodine-125 trans perineal prostate brachytherapy with pre-planning technique: pre and post-implant dosimetry results analysis; Curietherapie prostatique transperineale par iode 125 avec dosimetrie previsionnelle: analyse des resultats dosimetriques pre- et post-implantation

    Energy Technology Data Exchange (ETDEWEB)

    Simonian-Sauve, M.; Smart, C.; Mailleux, H.; Rosello, R.; Salem, N. [Institut Paoli Calmettes, 13 - Marseille (France); Bladou, F. [Hopital Salvador, 13 - Marseille (France)

    2003-04-01

    Post-implant CT-based dosimetry is the only method of assessing the quality of permanent prostate brachytherapy. As a consequence of our permanent feedback with the pre-planned technique, geometric and dosimetric criteria for optimal seed implantation are proposed and pre and post-implantation dosimetric results are presented. In 2000 and 2001, one hundred and twenty patients with early stage prostate cancer were treated with trans-perineal I-125 pre-planned brachytherapy (RAPID Strand{sup TM}, Amersham Health). The prescription dose was 145 Gy to the planning target volume. For the pre-planning and post-implant dosimetry the Variseed 6.7 version software was used (Varian Medical Systems). The D90, V 100 and V 150 values, the position of the dose peak [Dose] peak) and the full width at half maximum (FWHM) on differential dose volume histogram from both planned and post-implant dosimetry were compared for all patients. For pre-planned dosimetry, the mean values for D90, V100, V150, [Dose] peak, FWMH were respectively of 199 Gy, 100%, 70%, 220 Gy, 113 Gy. For post-implantation, these values became respectively of 157 Gy, 90%, 62%, 220 Gy, 194 Gy. In our practice, differences are noted between pre-planned and post-implant dosimetry parameters that should be anticipated to assure optimal definitive result. A working methodology both for performing the pre-planned dosimetry and for evaluating the post-implantation dosimetric results is proposed. (authors)

  19. External-Beam Radiation Therapy and High–Dose Rate Brachytherapy Combined With Long-Term Androgen Deprivation Therapy in High and Very High Prostate Cancer: Preliminary Data on Clinical Outcome

    International Nuclear Information System (INIS)

    Purpose: To determine the feasibility of combined long-term androgen deprivation therapy (ADT) and dose escalation with high-dose-rate (HDR) brachytherapy. Methods and Materials: Between 2001 and 2007, 200 patients with high-risk prostate cancer (32.5%) or very high-risk prostate cancer (67.5%) were prospectively enrolled in this Phase II trial. Tumor characteristics included a median pretreatment prostate-specific antigen of 15.2 ng/mL, a clinical stage of T2c, and a Gleason score of 7. Treatment consisted of 54 Gy of external irradiation (three-dimensional conformal radiotherapy [3DCRT]) followed by 19 Gy of HDR brachytherapy in four twice-daily treatments. ADT started 0–3 months before 3DCRT and continued for 2 years. Results: One hundred and ninety patients (95%) received 2 years of ADT. After a median follow-up of 3.7 years (range, 2–9), late Grade ≥2 urinary toxicity was observed in 18% of the patients and Grade ≥3 was observed in 5%. Prior transurethral resection of the prostate (p = 0.013) and bladder D50 ≥1.19 Gy (p = 0.014) were associated with increased Grade ≥2 urinary complications; age ≥70 (p = 0.05) was associated with Grade ≥3 urinary complications. Late Grade ≥2 gastrointestinal toxicity was observed in 9% of the patients and Grade ≥3 in 1.5%. CTV size ≥35.8 cc (p = 0.007) and D100 ≥3.05 Gy (p = 0.01) were significant for increased Grade ≥2 complications. The 5-year and 9-year biochemical relapse-free survival (nadir + 2) rates were 85.1% and 75.7%, respectively. Patients with Gleason score of 7–10 had a decreased biochemical relapse-free survival (p = 0.007). Conclusions: Intermediate-term results at the 5-year time point indicate a favorable outcome without an increase in the rate of late complications.

  20. A comparison of complications between ultrasound-guided prostate brachytherapy and open prostate brachytherapy

    International Nuclear Information System (INIS)

    Purpose: Prostate brachytherapy has reemerged during the 1990s as a treatment for clinically localized prostate cancer. The renewed popularity of prostate brachytherapy is largely due to the use of transrectal ultrasound of the prostate, which allows for more accurate isotope placement within the prostate when compared to the open approach. The present study investigates whether this improved cancer control is at the expense of increased morbidity by comparing the morbidity after transrectal ultrasound-guided prostate brachytherapy to the morbidity after prostate brachytherapy performed via an open approach. Methods and Materials: All men in the Medicare population who underwent prostate brachytherapy in the year 1991 were identified. These men were further stratified into those men who underwent prostate brachytherapy via an open approach and the men who underwent prostate brachytherapy with ultrasound guidance. All subsequent inpatient, outpatient, and physician (Part B) Medicare claims for these men from the years 1991-1993 were then analyzed to determine outcomes. Results: In the year 1991, 2124 men in the Medicare population underwent prostate brachytherapy. An open approach was used in 715 men (33.7%), and ultrasound guidance was used in 1409 men (66.3%). Mean age for both cohorts was 73.7 years with a range of 50.7-92.8 years for the ultrasound group and 60.6-92.1 years for the open group. A surgical procedure for the relief of bladder outlet obstruction was performed in 122 men (8.6%) in the ultrasound group and in 54 men (7.6%) in the open group. An artificial urinary sphincter was placed in 2 men (0.14%) in the ultrasound group and in 2 men (0.28%) in the open group. A penile prosthesis was implanted in 10 men (0.71%) in the ultrasound group and in 4 men (0.56%) in the open group. A diagnosis code for urinary incontinence was carried by 95 men (6.7%) in the ultrasound group and by 45 men (6.3%) in the open group. A diagnosis code for erectile dysfunction

  1. Decision-Making in Flight with Different Convective Weather Information Sources: Preliminary Results

    Science.gov (United States)

    Latorella, Kara A.; Chamberlain, James P.

    2004-01-01

    This paper reports preliminary and partial results of a flight experiment to address how General Aviation (GA) pilots use weather cues to make flight decisions. This research presents pilots with weather cue conditions typically available to GA pilots in visual meteorological conditions (VMC) and instrument meteorological conditions (IMC) today, as well as in IMC with a Graphical Weather Information System (GWIS). These preliminary data indicate that both VMC and GWIS-augmented IMC conditions result in better confidence, information sufficiency and perceived performance than the current IMC condition. For all these measures, the VMC and GWIS-augmented conditions seemed to provide similar pilot support. These preliminary results are interpreted for their implications on GWIS display design, training, and operational use guidelines. Final experimental results will compare these subjective data with objective data of situation awareness and decision quality.

  2. Restenosis: Intracoronary Brachytherapy.

    Science.gov (United States)

    Drachman, Douglas E.; Simon, Daniel I.

    2002-04-01

    Though interventional strategies have revolutionized the management of patients with symptomatic coronary artery disease, in-stent restenosis has emerged as the single most important limitation of long-term success following percutaneous coronary intervention. Once present, in-stent restenosis is extraordinarily difficult to treat, with conventional revascularization techniques failing in 50% to 80% of patients. Intracoronary radiation, or brachytherapy, targets cellular proliferation within the culprit neointima. Clinical trials have demonstrated that brachytherapy is a highly effective treatment for in-stent restenosis, reducing angiographic restenosis by 50% to 60% and the need for target vessel revascularization by 40% to 50%. The benefits of intracoronary brachytherapy may be particularly pronounced in certain patient subgroups (eg, those with diabetes, long lesions, or lesions in saphenous vein bypass grafts), but comes at the cost of an increased rate of late stent thrombosis and the need for extended antiplatelet therapy. The role of brachytherapy in the arsenal of the interventional cardiologist will continue to evolve, particularly in light of the unprecedented recent advances with the use of drug-eluting stents for restenosis prevention. PMID:11858773

  3. Results of high dose rate afterloading brachytherapy boost to conventional external beam radiation therapy for initial and locally advanced prostate cancer

    International Nuclear Information System (INIS)

    Purpose: To evaluate the impact on biochemical control (bNED), acute and late gastro-intestinal (GI) and urological (GU) morbidity of initial and locally advanced prostate cancer treated with fractionated transrectal ultrasound-guided (TRUS) high dose rate after loading brachytherapy (HDR-B) as a boost to conventional external beam radiation therapy (EBRT). Patients and methods: From March 1997 to February 2000 a total of 119 patients with any of the following characteristics were eligible for study entry: biopsy proven adenocarcinoma Gleason scored (GS), initial prostatic specific antigen (PSA) level dosage 1992 AJCC clinical stage T3a or less, and prostatic volume <60 cc. All patients had prior to HDR-B a course of EBRT 6 MV photons to a median dose of 45 Gy, in 1.8 Gy fractions, to the prostate and seminal vesicles only. HDR-B treatment planning and dosimetric calculations were generated with the Nucletron Planning System. Patients were grouped into two groups, according to their risk for biochemical failure: low-risk group without (LR) or with neoadjuvant total androgen deprivation (AD) prior to EBRT (LR+AD) and high-risk group without (HR) or with neoadjuvant AD (HR+AD), for bNED and dose-escalation protocol. LR encompassed patients who presented GS<6, T1 or T2a and or initial PSA<10 ng/ml, who were treated with 16 Gy (4 Gy fractions, b.i.d.) HDR-B. The remaining patients were grouped into HR or HR+AD and received 20 Gy (5 Gy fractions, b.i.d.) HDR-B. The planning was optimized using the standard geometric optimization. Biological effective doses (BED) for tumor control and late responding tissue were calculated using a α/β ratio of 1.5 and 3 Gy, respectively. They were matched with bNED, acute and late gastrointestinal (GI) and urological (GU) morbidity, according to the RTOG/EORTC scoring criteria. Results: Median age of patients was 68 years (range 47-83), with a median follow-up of 41 months (range 18-48). The crude and actuarial biochemical controls (b

  4. Impact of 3D image-based PDR brachytherapy on outcome of patients treated for cervix carcinoma in France: Results of the French STIC prospective study

    International Nuclear Information System (INIS)

    Purpose: In 2005 a French multicentric non randomized prospective study was initiated to compare two groups of patients treated for cervix carcinoma according to brachytherapy (BT) method: 2D vs 3D dosimetry. The BT dosimetric planning method was chosen for each patient in each center according to the availability of the technique. This study describes the results for 705 out of 801 patients available for analysis. Patients and methods: For the 2D arm, dosimetry was planned on orthogonal X-Rays using low dose rate (LDR) or pulsed dose rate (PDR) BT. For the 3D arm, dosimetry was planned on 3D imaging (mainly CT) and performed with PDR BT. Each center could follow the dosimetric method they were used to, according to the chosen radioelement and applicator. Manual or graphical optimization was allowed. Three treatment regimens were defined: Group 1: BT followed by surgery; 165 patients (2D arm: 76; 3D arm: 89); Group 2: EBRT (+chemotherapy), BT, then surgery; 305 patients (2D arm: 142; 3D arm: 163); Group 3: EBRT (+chemotherapy), then BT; 235 patients, (2D arm: 118; 3D arm: 117). The DVH parameters for CTVs (High Risk CTV and Intermediate Risk CTV) and organs at risk (OARs) were computed as recommended by GYN GEC ESTRO guidelines. Total doses were converted to equivalent doses in 2 Gy fractions (EQD2). Side effects were prospectively assessed using the CTCAEv3.0. Results: The 2D and 3D arms were well balanced with regard to age, FIGO stage, histology, EBRT dose and chemotherapy. For each treatment regimen, BT doses and volumes were comparable between the 2D and 3D arms in terms of dose to point A, isodose 60 Gy volume, dose to ICRU rectal points, and TRAK. Dosimetric data in the 3D arm showed that the dose delivered to 90% of the High Risk CTV (HR CTV D90) was respectively, 81.2 Gyα/β10, 63.2 Gyα/β10 and 73.1 Gyα/β10 for groups 1, 2 and 3. The Intermediate Risk (IR) CTV D90 was respectively, 58.5 Gyα/β10, 57.3 Gyα/β10 and 61.7 Gyα/β10 for groups 1, 2 and

  5. Preliminary results from the 51Cr neutrino source experiment in GALLEX

    International Nuclear Information System (INIS)

    The GALLEX collaboration performed a second 51Cr neutrino source experiment during fall 1995. The full results from this second source experiment will not be available before the end of 1996. Meanwhile, we present a short description and preliminary results in this informal note. The (preliminary) value of the activity obtained form direct measurements has been found equal to (68.7 ±0.7) PBq (with 1-sigma error). This value, which is about 10% higher than the activity of the first source, was achieved by optimizing the irradiation conditions in the Siloacute e reactor and doing a longer irradiation of the enriched chromium. Preliminary results show that the ratio, R, of the radiochemically determined activity from 71Ge counting (57.1 ± PBq) to the directly measured activity is (0.83 ± 0.10). The combined value of R for the two source experiments is (0.92 ± 0.08)

  6. 76 FR 2655 - Honey From Argentina: Preliminary Results of Antidumping Duty Administrative Review

    Science.gov (United States)

    2011-01-14

    ...: Honey From Argentina, 66 FR 63672 (December 10, 2001). On December 1, 2009, the Department published in... Memorandum; see e.g., Honey from Argentina: Final Results of Antidumping Duty Administrative Review, 70 FR... to Patagonik. See, e.g., Honey From Argentina: Preliminary Results of New Shipper Review, 71 FR...

  7. Severe rectal complications after prostate brachytherapy

    International Nuclear Information System (INIS)

    Purpose: Some investigators have reported severe rectal complications after brachytherapy. Due to the low number of such events, their relationship to dosimetric parameters has not been well characterized. Methods and materials: A total of 3126 patients were treated with low dose rate brachytherapy from 1998 through 2010. 2464 had implant alone, and 313 had implant preceded by 44–46 Gy supplemental external beam radiation (EBRT). Post-implant dosimetry was based on a CT scan obtained on the day of implant, generally within 30 min of the procedure. Every patient’s record was reviewed for occurrence of rectal complications. Results: Eight of 2464 patients (0.32%) treated with brachytherapy alone developed a radiation-related rectal fistula. Average prostatic and rectal dose parameters were moderately higher for fistula patients than for patients without a severe rectal complication. For instance, the average R100 was 1.2 ± 0.75 cc for fistula patients, versus 0.37 ± 0.88 cc for non-fistula patients. However, the fistula patients’ values were well within the range of values for patients without a rectal complication. Four patients had some attempt at repair or reconstruction, but long-term functional outcomes were not favorable. Conclusions: Rectal fistulas are a very uncommon potential complication of prostate brachytherapy, which can occur even in the setting of acceptable day 0 rectal doses. Their occurrence is not easily explained by standard dosimetric or clinical factors

  8. Early voiding dysfunction associated with prostate brachytherapy.

    Science.gov (United States)

    Wagner; Nag; Young; Bahnson

    2000-12-15

    Introduction: Transperineal prostate brachytherapy is gaining popularity as a treatment for clinically localized carcinoma of the prostate. Very little prospective data exists addressing the issue of complications associated with this procedure. We present an analysis of the early voiding dysfunction associated with prostate brachytherapy. Materials and Methods: Forty-six consecutive patients who underwent Palladium-103 (Pd-103) seed placement for clinically localized prostate carcinoma were evaluated prospectively for any morbidity associated with the procedure. Twenty-three patients completed an International Prostate Symptom Score (IPSS) questionnaire preoperatively, at their first postoperative visit, and at their second postoperative visit. The total IPSS, each of the seven individual components, and the "bother" score were evaluated separately for each visit, and statistical significance was determined. Results: Urinary retention occurred in 7/46 patients (15%). Of these, 5 were able to void spontaneously after catheter removal. One patient is maintained with a suprapubic tube, and one patient is currently on continuous intermittent catheterization. Baseline IPSS was 7.1 and this went to 20.0 at the first postoperative visit (p<0.001). By the second postoperative visit, the IPSS was 8.0. Conclusions: In our experience, prostate brachytherapy for localized carcinoma of the prostate is associated with a 15% catheterization rate and a significant increase in the IPSS (7.1 to 20.0). This increase in the IPSS seems to be self-limited. Patients need to be educated on these issues prior to prostate brachytherapy. PMID:11113369

  9. Registration and matching of tomographic and projection images: preliminary results of an hybrid solution in radiosurgery

    International Nuclear Information System (INIS)

    A new method for 2-dimensional/3-dimensional registration, applied to Magnetic Resonance Imaging (3-dimensional) and to X-Ray angiography (2-dimensional), has been adapted and used for planning treatment in radiosurgery. The imaging flow needed for planning radiosurgery is considerable and using registration technique would make lighter the imaging protocol without restricting planning. We describe the preliminary results of the evaluation giving criteria to compare registration technique and localization using stereotactic frame, which is the gold standard method. Preliminary results obtained during this first step in validating registration put forward which kind of MRI sequence are more suitable to registration. (authors)

  10. CT-based interstitial HDR brachytherapy

    Energy Technology Data Exchange (ETDEWEB)

    Kolotas, C.; Baltas, D.; Zamboglou, N. [Staedtische Kliniken Offenbach (Germany). Strahlenklinik

    1999-09-01

    Purpose: Development, application and evaluation of a CT-guided implantation technique and a fully CT-based treatment planning procedure for brachytherapy. Methods and Materials: A brachytherapy procedure based on CT-guided implantation technique and CT-based treatment planning has been developed and clinical evaluated. For this purpose a software system (PROMETHEUS) for the 3D reconstruction of brachytherapy catheters and patient anatomy using only CT scans has been developed. An interface for the Nucletron PLATO BPS treatment planning system for optimization and calculation of dose distribution has been devised. The planning target volume(s) are defined as sets of points using contouring tools and are used for optimization of the 3D dose distribution. Dose-volume histogram based analysis of the dose distribution (COIN analysis) enables a clinically realistic evaluation of the brachytherapy application to be made. The CT-guided implantation of catheters and the CT-based treatment planning procedure has been performed for interstitial brachytherapy and for different tumor sites in 197 patients between 1996 and 1997. Results: The accuracy of the CT reconstruction was tested using first a quality assurance phantom and second, a simulated interstitial implant of 12 needles. These were compared with the results of reconstruction using radiographs. Both methods gave comparable results with regard to accuracy, but the CT based reconstruction was faster. Clinical feasibility was proved in pre-irradiated recurrences of brain tumors, in pretreated recurrences or metastatic disease, and in breast carcinomas. The tumor volumes treated were in the range 5.1 to 2,741 cm{sup 3}. Analysis of implant quality showed a slightly significant lower COIN value for the bone implants, but no differences with respect to the planning target volume. Conclusions: The Offenbach system, incorporating the PROMETHEUS software for interstitial HDR brachytherapy has proved to be extremely valuable

  11. Cognitive Task Analysis of Business Jet Pilots' Weather Flying Behaviors: Preliminary Results

    Science.gov (United States)

    Latorella, Kara; Pliske, Rebecca; Hutton, Robert; Chrenka, Jason

    2001-01-01

    This report presents preliminary findings from a cognitive task analysis (CTA) of business aviation piloting. Results describe challenging weather-related aviation decisions and the information and cues used to support these decisions. Further, these results demonstrate the role of expertise in business aviation decision-making in weather flying, and how weather information is acquired and assessed for reliability. The challenging weather scenarios and novice errors identified in the results provide the basis for experimental scenarios and dependent measures to be used in future flight simulation evaluations of candidate aviation weather information systems. Finally, we analyzed these preliminary results to recommend design and training interventions to improve business aviation decision-making with weather information. The primary objective of this report is to present these preliminary findings and to document the extended CTA methodology used to elicit and represent expert business aviator decision-making with weather information. These preliminary findings will be augmented with results from additional subjects using this methodology. A summary of the complete results, absent the detailed treatment of methodology provided in this report, will be documented in a separate publication.

  12. An assessment of the radiological impact of brachytherapy application in Metro Manila hospitals

    International Nuclear Information System (INIS)

    One of the most important uses of radioactive sources in medicine is the application of brachytherapy technology. Brachytherapy is a method of radiation therapy where an encapsulated radioactive source delivers gamma or beta radiation into a tumor site. The paper describes different categories of brachytherapy applications involving manual insertion or afterloading and remote afterloading techniques. A list of five hospitals in Metro Manila practicing different techniques of brachytherapy are enumerated. Because of the widespread uses of radioactive sources in brachytherapy technology in medicine, inadequate control in its use had led to a number of incidents resulting to unnecessary exposure of radiation workers, patients and general public. This study was initiated to determine the radilogical hazards involved in brachytherapy applications. It presents contingency scenarios and their projected radiological consequences. (author). 7 refs., 2 tabs

  13. Nb/NiCu bilayers in single and stacked superconductive tunnel junctions: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Pepe, G.P. E-mail: ruotolo_antonio@tin.it; Ruotolo, A.; Parlato, L.; Peluso, G.; Ausanio, G.; Carapella, G.; Latempa, R

    2004-05-01

    We present preliminary experimental results concerning both single and stacked tunnel junctions in which one of the electrodes was formed by a superconductor/ferromagnet (S/F) bi-layer. In particular, in the stacked configuration a Nb/NiCu bi-layer was used as the intermediate electrode, and it was probed by tunneling on both sides. Tunnel junctions have been characterized in terms of current-voltage characteristics (IVC), and differential conductance. Preliminary steady-state injection-detection measurements performed in the stacked devices at T=4.2 K are also presented and discussed.

  14. Nb/NiCu bilayers in single and stacked superconductive tunnel junctions: preliminary results

    International Nuclear Information System (INIS)

    We present preliminary experimental results concerning both single and stacked tunnel junctions in which one of the electrodes was formed by a superconductor/ferromagnet (S/F) bi-layer. In particular, in the stacked configuration a Nb/NiCu bi-layer was used as the intermediate electrode, and it was probed by tunneling on both sides. Tunnel junctions have been characterized in terms of current-voltage characteristics (IVC), and differential conductance. Preliminary steady-state injection-detection measurements performed in the stacked devices at T=4.2 K are also presented and discussed

  15. Preliminary results of the scientific experiments on the Kosmos-936 biosatellite

    Science.gov (United States)

    1977-01-01

    The scientific equipment and experiments on the Kosmos-936 biosatellite are described, including various ground controls and the lab unit for studies at the descent vehicle landing site. Preliminary results are presented of the physiological experiment with rats, biological experiments with drosophila and higher and lower plants, and radiation physics and radiobiology studies for the planning of biological protection on future space flights. The most significant conclusion from the preliminary data is that rats tolerate space flight better with an artificial force of gravity.

  16. American Brachytherapy Society (ABS) recommendations for transperineal permanent brachytherapy of prostate cancer

    International Nuclear Information System (INIS)

    Purpose/Objective: To develop and disseminate the American Brachytherapy Society (ABS) recommendations for the clinical quality assurance and guidelines of permanent transperineal prostate brachytherapy with 125I or 103Pd. Methods and Materials: The ABS formed a committee of experts in prostate brachytherapy to develop consensus guidelines through a critical analysis of published data supplemented by their clinical experience. The recommendations of the panels were reviewed and approved by the Board of Directors of the ABS. Results: Patients with high probability of organ-confined disease are appropriately treated with brachytherapy alone. Brachytherapy candidates with a significant risk of extraprostatic extension should be treated with supplemental external beam radiation therapy (EBRT). Patient selection guidelines were developed. Dosimetric planning of the implant should be carried out for all patients before seed insertion. A modified peripheral loading is preferred. The AAPM TG-43 recommendations requiring a change in prescription dose for 125I sources should be universally implemented. The recommended prescription doses for monotherapy are 145 Gy for 125I and 115-120 Gy for 103Pd. The corresponding boost doses (after 40-50 Gy EBRT) are 100-110 Gy and 80-90 Gy, respectively. Clinical evidence to guide selection of radionuclide (103Pd or 125I) is lacking. Post implant dosimetry and evaluation must be performed on all patients. It is suggested that the dose that covers 90% (D90) and 100% (D100) of the prostate volume and the percentage of the prostate volume receiving the prescribed dose (V100) be obtained from a dose-volume histogram (DVH) and reported. Conclusion: Guidelines for appropriate patient selection, dose reporting, and improved quality of permanent prostate brachytherapy are presented. These broad recommendations are intended to be technical and advisory in nature, but the ultimate responsibility for the medical decisions rests with the treating

  17. 77 FR 73422 - Seamless Refined Copper Pipe and Tube From Mexico: Preliminary Results of Antidumping Duty...

    Science.gov (United States)

    2012-12-10

    ... International Trade Administration Seamless Refined Copper Pipe and Tube From Mexico: Preliminary Results of... administrative review of the antidumping duty order on seamless refined copper pipe and tube from Mexico. The... description, available in Seamless Refined Copper Pipe and Tube From Mexico and the People's Republic of...

  18. Three-dimensional Simulations of Thermonuclear Detonation with α-Network: Numerical Method and Preliminary Results

    Science.gov (United States)

    Khokhlov, A.; Domínguez, I.; Bacon, C.; Clifford, B.; Baron, E.; Hoeflich, P.; Krisciunas, K.; Suntzeff, N.; Wang, L.

    2012-07-01

    We describe a new astrophysical version of a cell-based adaptive mesh refinement code ALLA for reactive flow fluid dynamic simulations, including a new implementation of α-network nuclear kinetics, and present preliminary results of first three-dimensional simulations of incomplete carbon-oxygen detonation in Type Ia Supernovae.

  19. 78 FR 34644 - Stainless Steel Plate in Coils From Belgium: Preliminary Results of Antidumping Duty...

    Science.gov (United States)

    2013-06-10

    ... International Trade Administration Stainless Steel Plate in Coils From Belgium: Preliminary Results of... administrative review of the antidumping duty order on stainless steel plate in coils (steel plate) from Belgium...: Scope of the Order The product covered by this order is certain stainless steel plate in...

  20. 75 FR 81217 - Stainless Steel Plate in Coils From Belgium: Preliminary Results of Full Sunset Review

    Science.gov (United States)

    2010-12-27

    ... International Trade Administration Stainless Steel Plate in Coils From Belgium: Preliminary Results of Full... review of the countervailing duty (``CVD'') order on certain stainless steel plate in coils from Belgium... June 2, 2010, the Department initiated the second sunset review of the CVD order on stainless...

  1. 78 FR 7395 - Stainless Steel Bar From India: Preliminary Results of Antidumping Duty Administrative Review...

    Science.gov (United States)

    2013-02-01

    ... Determination of Sales at Less Than Fair Value: Stainless Steel Bar from India, 59 FR 66915, 66921 (December 28... International Trade Administration Stainless Steel Bar From India: Preliminary Results of Antidumping Duty... the antidumping duty order on stainless steel bar (SSB) from India. The period of review (POR)...

  2. The effect of parental involvement in CBT of anxious children: Preliminary results from a RCT study

    DEFF Research Database (Denmark)

    Esbjørn, Barbara Hoff; Breinholst, Sonja; Reinholdt-Dunne, Marie Louise;

    2011-01-01

    Esbjørn, B. H., Breinholst, S., Reinholdt-Dunne, M. L., & Leth, I. (2011). The effect of parental involvement in CBT of anxious children: Preliminary results from a RCT study. Poster accepted for the Association for Behavioral and Cognitive Therapies, Toronto, Canada....

  3. 76 FR 26241 - Polyethylene Retail Carrier Bags From Thailand: Extension of Time Limit for Preliminary Results...

    Science.gov (United States)

    2011-05-06

    ..., 75 FR 60076 (September 29, 2010). The preliminary results of this administrative review are currently... International Trade Administration Polyethylene Retail Carrier Bags From Thailand: Extension of Time Limit for... polyethylene retail carrier bags from Thailand for the period August 1, 2009, through July 31, 2010....

  4. Preliminary Results from Second Phase Sea Testing of the Wave Dragon Prototype Wave Energy Converter

    DEFF Research Database (Denmark)

    Soerensen, Hans Chr.; Tedd, James; Friis-Madsen, Erik; Kofoed, Jens Peter

    2006-01-01

    In March 2006 the prototype Wave Dragon has been redeployed to a more energetic site in Nissum Bredning an inland sea in Western Denmark. This has followed a period of renovation of many aspects of the device which have resulted in 20% higher energy output. This paper describes the preliminary...

  5. 77 FR 42273 - Solid Urea From the Russian Federation: Preliminary Results of Antidumping Duty Administrative...

    Science.gov (United States)

    2012-07-18

    ... Revocation in Part, 76 FR 53404 (August 26, 2011). \\3\\ See Solid Urea From the Russian Federation: Extension of Time Limit for Preliminary Results of Antidumping Duty Administrative Review, 77 FR 17410 (March...: Final Modification, 77 FR 8101 (February 14, 2012) (``Final Modification for Reviews''). When...

  6. 78 FR 28192 - Polyethylene Retail Carrier Bags From Thailand: Preliminary Results of Antidumping Duty...

    Science.gov (United States)

    2013-05-14

    ... Carrier Bags From Thailand, 75 FR 48940 (August 12, 2010) (Section 129 Determination). Preliminary Results....69 Sun Pack Inter Co. Ltd 4.69 Apple Film Company, Ltd 4.69 Trinity Pac Co. Ltd 122.88 * No shipments... Antidumping and Countervailing Duty Proceedings: Assessment of Antidumping Duties, 68 FR 23954 (May 6,...

  7. Gas enhanced magnetic resonance angiography of the cerebrum using carbon dioxide and oxygen - preliminary results

    DEFF Research Database (Denmark)

    Pedersen, Mads Møller; Hansen, Kristoffer Lindskov; Ohlhues, Anders;

    meninges may obscure the signal from the arteries of interest. It is known that oxygen enhances the T1-weighted signal and that carbon dioxide increases the arterial blood flow. This paper presents preliminary results of gas enhanced MRA using combinations of atmospheric air, O2 and CO2. Subjects and...

  8. Preliminary results of the round-robin testing of F82H

    Energy Technology Data Exchange (ETDEWEB)

    Shiba, K.; Yamanouchi, N.; Tohyama, A.

    1996-10-01

    Preliminary results of metallurgical, physical and mechanical properties of low activation ferritic steel F82H (IEA heat) were obtained in the round-robin test in Japan. The properties of IEA heat F82H were almost the same as the original F82H.

  9. 77 FR 61742 - Certain Lined Paper Products From India: Preliminary Results of Countervailing Duty...

    Science.gov (United States)

    2012-10-11

    ... Duty Orders: Certain Lined Paper Products from India and Indonesia, 71 FR 56949 (September 28, 2006... International Trade Administration Certain Lined Paper Products From India: Preliminary Results of... administrative review of the countervailing duty order on certain lined paper products from India. The period...

  10. 78 FR 62584 - Certain Lined Paper Products From India: Preliminary Results of Countervailing Duty...

    Science.gov (United States)

    2013-10-22

    ... Duty Orders: Certain Lined Paper Products from India and Indonesia, 71 FR 56949 (September 28, 2006... International Trade Administration Certain Lined Paper Products From India: Preliminary Results of... administrative review of the countervailing duty (CVD) order on certain lined paper products from India....

  11. 76 FR 47558 - Polyethylene Terephthalate Film, Sheet, and Strip From India: Preliminary Results of...

    Science.gov (United States)

    2011-08-05

    ... interest-free contingent liability loans See, e.g., PET Film Preliminary Results of 2003 Review, 70 FR at... Terephthalate Film, Sheet, and Strip (PET Film) from India, 67 FR 44179 (July 1, 2002). On July 1, 2010, the... Administrative Review, 75 FR 38074 (July 1, 2010). The Department received a request for review from...

  12. 77 FR 32503 - Certain Polyester Staple Fiber From Taiwan: Preliminary Results of Antidumping Duty...

    Science.gov (United States)

    2012-06-01

    ... Review, 75 FR 39208 (July 8, 2010). \\2\\ See Initiation of Antidumping and Countervailing Duty Administrative Reviews and Requests for Revocation in Part, 76 FR 37781 (June 28, 2011). On January 30, 2012, in...: Extension of Time Limit for Preliminary Results of Antidumping Duty Administrative Review, 77 FR...

  13. Breast-conserving surgery after neoadjuvant chemotherapy in patients with locally advanced cancer. Preliminary results

    OpenAIRE

    VERGINE, M.; SCIPIONI, P.; GARRITANO, S.; COLANGELO, M.; Di Paolo, A; LIVADOTI, G.; MATURO, A.; Monti, M

    2013-01-01

    Neoadjuvant chemotherapy (NACT) in locally advanced breast tumors may allow an adequate control of the disease impossible with surgery alone. Moreover, NACT increases the chance of breast-conserving surgery. Between 2008 and 2012, we treated with NACT 83 patients with locally advanced breast cancer. We report the preliminary results evaluating the impact of NACT on the type of surgery.

  14. Preliminary results from a laboratory study of charging mechanisms in a dusty plasma

    International Nuclear Information System (INIS)

    A laboratory investigation has been developed to experimentally study the interaction of micron sized particles with plasmas and electromagnetic radiation. The intent is to investigate under what conditions particles of various compositions and sizes become charged, or discharged, while exposed to an electron beam. Primary emphasis in this report is on secondary emission of electrons. Preliminary results are presented

  15. 77 FR 73615 - Lightweight Thermal Paper From Germany; Preliminary Results of Antidumping Duty Administrative...

    Science.gov (United States)

    2012-12-11

    ... Thermal Paper from Germany and the People's Republic of China, 73 FR 70959 (November 24, 2008) (Orders...: Assessment of Antidumping Duties, 68 FR 23954 (May 6, 2003). Assessment of Antidumping Duties We intend to... International Trade Administration Lightweight Thermal Paper From Germany; Preliminary Results of...

  16. 78 FR 15686 - Certain Frozen Warmwater Shrimp From Thailand: Preliminary Results of Antidumping Duty...

    Science.gov (United States)

    2013-03-12

    ... FR 40881, 40883 (July 12, 2011); see also the ``Preliminary Determination To Revoke Order, In Part... Administrative Review, 73 FR 12088 (March 6, 2008), unchanged in Certain Frozen Warmwater Shrimp From Thailand: Final Results and Final Partial Rescission of Antidumping Duty Administrative Review, 73 FR...

  17. 76 FR 4292 - Certain Frozen Fish Fillets From the Socialist Republic of Vietnam: Preliminary Results of...

    Science.gov (United States)

    2011-01-25

    ... Fillets from the Socialist Republic of Vietnam, 68 FR 47909 (August 12, 2003) (``Order''). The Department... Socialist Republic of Vietnam (``Verification Report''), issued concurrently with these preliminary results... Antidumping Duty New Shipper Reviews, 75 FR 57261(September 20, 2010). Surrogate Country and Surrogate...

  18. Glass microspheres for brachytherapy

    International Nuclear Information System (INIS)

    We developed the capacity to produce glass microspheres containing in their structure one or more radioactive isotopes useful for brachytherapy. We studied the various facts related with their production: (Rare earth) alumino silicate glass making, glass characterization, microspheres production, nuclear activation through (n,γ) nuclear reactions, mechanical characterization before and after irradiation. Corrosion tests in simulated human plasma and mechanical properties characterization were done before and after irradiation. (author)

  19. Late Urinary Side Effects 10 Years After Low-Dose-Rate Prostate Brachytherapy: Population-Based Results From a Multiphysician Practice Treating With a Standardized Protocol and Uniform Dosimetric Goals

    Energy Technology Data Exchange (ETDEWEB)

    Keyes, Mira, E-mail: mkeyes@bccancer.bc.ca; Miller, Stacy; Pickles, Tom; Halperin, Ross; Kwan, Winkle; Lapointe, Vincent; McKenzie, Michael; Spadinger, Ingrid; Pai, Howard; Chan, Elisa K.; Morris, W. James

    2014-11-01

    Purpose: To determine late urinary toxicity (>12 months) in a large cohort of uniformly treated low-dose-rate prostate brachytherapy patients. Methods and Materials: From 1998 to 2009, 2709 patients with National Comprehensive Cancer Network–defined low-risk and low-tier intermediate-risk prostate cancer were treated with Iodine 125 ({sup 125}I) low-dose-rate prostate brachytherapy; 2011 patients with a minimum of 25 months of follow-up were included in the study. Baseline patients, treatment, implant factors, and late urinary toxicity (Radiation Therapy Oncology Group [RTOG] grading system and International Prostate Symptom Score [IPSS]) were recorded prospectively. Time to IPSS resolution, late RTOG genitourinary toxicity was examined with Kaplan-Meier and log-rank tests. Cox proportional hazards regression was done for individual covariates and multivariable models. Results: Median follow-up was 54.5 months (range, 2-13 years). Actuarial toxicity rates reached 27% and 10% (RTOG ≥2 and ≥3, respectively) at 9-13 years. Symptoms resolved quickly in the majority of patients (88% in 6-12 months). The prevalence of RTOG 0, 1, 2, 3, and 4 toxicity with a minimum of 7 years' follow-up was 70%, 21%, 6.4%, 2.3%, and 0.08%, respectively. Patients with a larger prostate volume, higher baseline IPSS, higher D90, acute toxicity, and age >70 years had more late RTOG ≥2 toxicity (all P≤.02). The IPSS resolved slower in patients with lower baseline IPSS and larger ultrasound prostate volume, those not receiving androgen deprivation therapy, and those with higher D90. The crude rate of RTOG 3 toxicity was 6%. Overall the rate of transurethral resection of the prostate was 1.9%; strictures, 2%; incontinence, 1.3%; severe symptoms, 1.8%; late catheterization, 1.3%; and hematuria, 0.8%. The majority (80%) resolved their symptoms in 6-12 months. Conclusion: Long-term urinary toxicity after brachytherapy is low. Although actuarial rates increase with longer

  20. Late Urinary Side Effects 10 Years After Low-Dose-Rate Prostate Brachytherapy: Population-Based Results From a Multiphysician Practice Treating With a Standardized Protocol and Uniform Dosimetric Goals

    International Nuclear Information System (INIS)

    Purpose: To determine late urinary toxicity (>12 months) in a large cohort of uniformly treated low-dose-rate prostate brachytherapy patients. Methods and Materials: From 1998 to 2009, 2709 patients with National Comprehensive Cancer Network–defined low-risk and low-tier intermediate-risk prostate cancer were treated with Iodine 125 (125I) low-dose-rate prostate brachytherapy; 2011 patients with a minimum of 25 months of follow-up were included in the study. Baseline patients, treatment, implant factors, and late urinary toxicity (Radiation Therapy Oncology Group [RTOG] grading system and International Prostate Symptom Score [IPSS]) were recorded prospectively. Time to IPSS resolution, late RTOG genitourinary toxicity was examined with Kaplan-Meier and log-rank tests. Cox proportional hazards regression was done for individual covariates and multivariable models. Results: Median follow-up was 54.5 months (range, 2-13 years). Actuarial toxicity rates reached 27% and 10% (RTOG ≥2 and ≥3, respectively) at 9-13 years. Symptoms resolved quickly in the majority of patients (88% in 6-12 months). The prevalence of RTOG 0, 1, 2, 3, and 4 toxicity with a minimum of 7 years' follow-up was 70%, 21%, 6.4%, 2.3%, and 0.08%, respectively. Patients with a larger prostate volume, higher baseline IPSS, higher D90, acute toxicity, and age >70 years had more late RTOG ≥2 toxicity (all P≤.02). The IPSS resolved slower in patients with lower baseline IPSS and larger ultrasound prostate volume, those not receiving androgen deprivation therapy, and those with higher D90. The crude rate of RTOG 3 toxicity was 6%. Overall the rate of transurethral resection of the prostate was 1.9%; strictures, 2%; incontinence, 1.3%; severe symptoms, 1.8%; late catheterization, 1.3%; and hematuria, 0.8%. The majority (80%) resolved their symptoms in 6-12 months. Conclusion: Long-term urinary toxicity after brachytherapy is low. Although actuarial rates increase with longer follow

  1. Vapour explosions (fuel-coolant interactions) resulting from the sub-surface injection of water into molten metals: preliminary results

    International Nuclear Information System (INIS)

    Preliminary experiments are reported on the relationship between the injection mode of contact and the occurrence and magnitude of vapour explosions. Water was injected beneath the surface of molten metals, chiefly tin at 250 to 9000C. Vapour explosions occurred in many, but not all, cases. The results are compared with Dullforce's observations (Culham Report (CLM-P424) on the dropping mode of contact and it appears that rather different behaviour is found; in particular, the present results suggest that the Temperature Interaction Zone is different for the two modes of contact. (author)

  2. Preliminary results of natural radioactivity measurements in the southern part of Ethiopia

    International Nuclear Information System (INIS)

    The paper presents the first results of natural radioactivity measurements in the Southern part of Ethiopia (Bale Zone-Oromiya Regional State). The preliminary results indicate that radiation levels in the mining areas of Kallido Mountain are elevated compared with those in the town of Negele Borena (background area). Both external gamma radiation and alpha surface contamination levels are significantly elevated above local background levels

  3. Intracoronary irradiation with rhenium 188 to reduce restenosis following a coronary angioplasty. Preliminary results

    International Nuclear Information System (INIS)

    This paper shows the preliminary results from our contribution to a coordinated project with the International Atomic Energy Agency, which corroborates that the intracoronary irradiation allows to reduce the restenosis following a percutaneous transluminal coronary angioplasty (PTCA) in patients with ischemic cardiopathy as a result of neointima hyperplasia reduction. In the treatment, both beta and gamma emitters can be used, but with the latter (specifically with rhenium 188), its is possible to use an angioplasty balloon catheter for therapy purposes

  4. Comparative dosimetry in intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT for brain tumors

    Energy Technology Data Exchange (ETDEWEB)

    Brandao, Samia de Freitas, E-mail: samiabrandao@gmail.com [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Departamento de Engenharia Nuclear; Campos, Tarcisio Passos Ribeiro de [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil)

    2013-06-15

    Objective: comparative analysis of dosimetry in intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT for treatment of brain tumors. Materials and methods: simulations of intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT were performed with the MCNP5 code, modeling the treatment of a brain tumor on a voxel computational phantom representing a human head. Absorbed dose rates were converted into biologically weighted dose rates. Results: intracavitary balloon catheter brachytherapy with I-125 produced biologically weighted mean dose rates of 3.2E-11, 1.3E-10, 1.9E-11 and 6.9E-13 RBE.Gy.h{sup -1}.p{sup -1}.s, respectively, on the healthy tissue, on the balloon periphery and on the /{sub 1} and /{sub 2} tumor infiltration zones. On the other hand, Cf-252 brachytherapy combined with BNCT produced a biologically weighted mean dose rate of 5.2E-09, 2.3E-07, 8.7E-09 and 2.4E-09 RBE.Gy.h{sup -1}.p{sup -1}.s, respectively on the healthy tissue, on the target tumor and on the /{sub 1} and /{sub 2} infiltration zones. Conclusion: Cf-252 brachytherapy combined with BNCT delivered a selective irradiation to the target tumor and to infiltration zones, while intracavitary balloon catheter brachytherapy with I-125 delivered negligible doses on the tumor infiltration zones. (author)

  5. Comparative dosimetry in intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT for brain tumors

    Directory of Open Access Journals (Sweden)

    Samia de Freitas Brandao

    2013-07-01

    Full Text Available Objective Comparative analysis of dosimetry in intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT for treatment of brain tumors. Materials and Methods Simulations of intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT were performed with the MCNP5 code, modeling the treatment of a brain tumor on a voxel computational phantom representing a human head. Absorbed dose rates were converted into biologically weighted dose rates. Results Intracavitary balloon catheter brachytherapy with I-125 produced biologically weighted mean dose rates of 3.2E-11, 1.3E-10, 1.9E-11 and 6.9E-13 RBE.Gy.h-1.p-1.s, respectively, on the healthy tissue, on the balloon periphery and on the I 1 and I 2 tumor infiltration zones. On the other hand, Cf-252 brachytherapy combined with BNCT produced a biologically weighted mean dose rate of 5.2E-09, 2.3E-07, 8.7E-09 and 2.4E-09 RBE.Gy.h-1.p-1.s, respectively on the healthy tissue, on the target tumor and on the I 1 and I 2 infiltration zones. Conclusion Cf-252 brachytherapy combined with BNCT delivered a selective irradiation to the target tumor and to infiltration zones, while intracavitary balloon catheter brachytherapy with I-125 delivered negligible doses on the tumor infiltration zones.

  6. Comparative dosimetry in intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT for brain tumors

    International Nuclear Information System (INIS)

    Objective: comparative analysis of dosimetry in intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT for treatment of brain tumors. Materials and methods: simulations of intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT were performed with the MCNP5 code, modeling the treatment of a brain tumor on a voxel computational phantom representing a human head. Absorbed dose rates were converted into biologically weighted dose rates. Results: intracavitary balloon catheter brachytherapy with I-125 produced biologically weighted mean dose rates of 3.2E-11, 1.3E-10, 1.9E-11 and 6.9E-13 RBE.Gy.h-1.p-1.s, respectively, on the healthy tissue, on the balloon periphery and on the /1 and /2 tumor infiltration zones. On the other hand, Cf-252 brachytherapy combined with BNCT produced a biologically weighted mean dose rate of 5.2E-09, 2.3E-07, 8.7E-09 and 2.4E-09 RBE.Gy.h-1.p-1.s, respectively on the healthy tissue, on the target tumor and on the /1 and /2 infiltration zones. Conclusion: Cf-252 brachytherapy combined with BNCT delivered a selective irradiation to the target tumor and to infiltration zones, while intracavitary balloon catheter brachytherapy with I-125 delivered negligible doses on the tumor infiltration zones. (author)

  7. Preliminary experimental results on studying possibility of variable mass liner (VML) formation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    The main objective of the present experiment was to study the formation process and initial stage of acceleration of a variable-mass plasma liner (VML). The method is based on magnetic acceleration of a liner with the mass reduced during such acceleration. The experiment was carried out on February 16 at VNIIEF. This report describes the results of measurements obtained in the experiment and preliminary analysis of the results characterizing operation of the test facility main units: helical EMG; 5-module disk EMG 400 mm in diameter (DEMG); ponderomotive unit (PU) with a cylindric condensed liner and a special tooth-cutoff. The first part of the report presents measurement results obtained on the VNIIEF`s diagnostic equipment that are compared with those obtained by American specialists on their diagnostic equipment. Information submitted by American specialists is included in part 2 of this report. The second part of the report presents preliminary computational-theoretic analysis of the main measured results describing operation of DEMG TL system in the experiment; experimental data are compared with theoretical ones obtained before and after the experiment. But more emphasis is placed on the data preliminary analysis indicating that in the experiment a variable mass liner is formed (VML or plasma bubble).

  8. Preliminary experimental results on studying possibility of variable mass liner (VML) formation

    International Nuclear Information System (INIS)

    The main objective of the present experiment was to study the formation process and initial stage of acceleration of a variable-mass plasma liner (VML). The method is based on magnetic acceleration of a liner with the mass reduced during such acceleration. The experiment was carried out on February 16 at VNIIEF. This report describes the results of measurements obtained in the experiment and preliminary analysis of the results characterizing operation of the test facility main units: helical EMG; 5-module disk EMG 400 mm in diameter (DEMG); ponderomotive unit (PU) with a cylindric condensed liner and a special tooth-cutoff. The first part of the report presents measurement results obtained on the VNIIEF's diagnostic equipment that are compared with those obtained by American specialists on their diagnostic equipment. Information submitted by American specialists is included in part 2 of this report. The second part of the report presents preliminary computational-theoretic analysis of the main measured results describing operation of DEMG TL system in the experiment; experimental data are compared with theoretical ones obtained before and after the experiment. But more emphasis is placed on the data preliminary analysis indicating that in the experiment a variable mass liner is formed (VML or plasma bubble)

  9. Nucleon resonance decay by the $K^{0} \\sum^{+}$ channel: Preliminary results

    Indian Academy of Sciences (India)

    S V Shende; R Castelijns; J C S Bacelar; H Löhner; J Messchendorp; CBELSA/TAPS Collaboration

    2006-05-01

    The strange meson production on a proton target in the $K^{0} \\sum^{+}$ channel is sensitive to nucleon resonance contributions. The $K^{0}$ production on a deuteron target can provide information on the hyperon-nucleon final-state interaction. The experiments $ p → K^{0} \\sum^{+}$ and $ d → K^{0} \\sum^{+} n$ have been carried out at the ELSA facility at Bonn. In this paper, we report the preliminary results of both experiments.

  10. Preliminary Results of the Echo-Seeding Experiment ECHO-7 at SLAC

    Energy Technology Data Exchange (ETDEWEB)

    Xiang, D.; Colby, E.; Ding, Y.; Dunning, M.; Frederico, J.; Gilevich, S.; Hast, C.; Jobe, K.; McCormick, D.; Nelson, J.; Raubenheimer, T.O.; Soong, K.; Stupakov, G.; Szalata, Z.; Walz, D.; Weathersby, S.; Woodley, M.; /SLAC; Corlett, J.; Qiang, J.; Penn, G.; Prestemon, S.; /LBL, Berkeley /LPHE, Lausanne

    2010-06-15

    ECHO-7 is a proof-of-principle echo-enabled harmonic generation FEL experiment in the Next Linear Collider Test Accelerator (NLCTA) at SLAC. The experiment aims to generate coherent radiation at 318 nm and 227 nm, which are the 5th and 7th harmonic of the infrared seed laser. In this paper we present the preliminary results from the commissioning run of the completed experimental setup which started in April 2010.

  11. First steps of laparoscopic surgery in Lubumbashi: problems encountered and preliminary results

    OpenAIRE

    Arung, Willy; Dinganga, Nathalie; Ngoie, Emmanuel; Odimba, Etienne; Detry, Olivier

    2015-01-01

    For many reasons, laparoscopic surgery has been performed worldwide. Due to logistical constraints its first steps occurred in Lubumbashi only in 2008. The aim of this presentation was to report authors’ ten-month experience of laparoscopic surgery at Lubumbashi Don Bosco Missionary Hospital (LDBMH): problems encountered and preliminary results. The study was a transsectional descriptive work with a convenient sampling. It only took in account patients with abdominal surgical condition who co...

  12. Facial emotional recognition in schizophrenia: preliminary results of the virtual reality program for facial emotional recognition

    OpenAIRE

    Teresa Souto; Alexandre Baptista; Diana Tavares; Cristina Queirós; Marques António

    2013-01-01

    BACKGROUND: Significant deficits in emotional recognition and social perception characterize patients with schizophrenia and have direct negative impact both in inter-personal relationships and in social functioning. Virtual reality, as a methodological resource, might have a high potential for assessment and training skills in people suffering from mental illness. OBJECTIVES: To present preliminary results of a facial emotional recognition assessment designed for patients with schizophrenia,...

  13. The evaluation of GL impact in Physical sciences using bibliometric indicators : preliminary results

    OpenAIRE

    Di Cesare, Rosa; GreyNet, Grey Literature Network Service

    1994-01-01

    A bibliometric study of the Italian grey literature in SIGLE database. Preliminary results. Given the increasing importance of Grey Literature (GL) for the information and documentation field, it is essential to apply a bibliometric analysis similar to the one widely used for the conventional literature. Study objectives: 1) impact evalutation of grey literature in physical sciences; and 2) differentiation between scientific and non scientific grey literature documents in the same discipline,...

  14. The RPC-based IFR system at BaBar experiment preliminary results

    CERN Document Server

    Piccolo, D; Bagnasco, S; Baldini, R; Band, H R; Bionta, R; Buzzo, A; Calcaterra, A; Cavallo, N; Contri, R; Crosetti, G; De Nardo, Gallieno; De Sangro, R; Fabozzi, F; Falciai, D; Finocchiaro, G; Gatto, C; Johnson, J; Lista, L; Lo Vetere, M; Macri, M; Monge, R; Palano, A; Paolucci, P; Passaggio, S; Patrignani, C; Patteri, P; Peruzzi, I; Piccolo, M; Robutti, E; Santroni, A; Sciacca, C; Wright, D; Yu, Z; Zallo, A

    2002-01-01

    The IFR system is a RPC-based detector used to identify muons and neutral hadrons in the BaBar experiment at PEP II machine in SLAC. The RPC system can be used to reconstruct the trajectory of muons, pions and neutral hadrons interacting in the iron of the IFR. The different range and hit pattern allow to discriminate different particles crossing the IFR. An overview of the system design and the preliminary results on the IFR performances are reported.

  15. Preliminary results from a passive seismic array over the Chicxulub impact structure in Mexico

    OpenAIRE

    P. K. H. Maguire; Mackenzie, G D; Denton, P.; Trejo, A.; Rainer Kind

    1998-01-01

    A passive, 20-element, short-period (1 Hz) and broadband seismic array was deployed over the Chicxulub impact structure for c. 100 days in early 1996. The principal objective was to study the shear-wave anisotropy associated with the structure; in particular, to determine the presence (or absence= of radial symmetry which will allow comment on the time variance of that anisotropy. A total of 15 teleseismic, 75 regional, and 100 local events were recorded. Preliminary results from studies of t...

  16. Parallel Guided Local Search and Some Preliminary Experimental Results for Continuous Optimization

    Directory of Open Access Journals (Sweden)

    Nasser Tairan

    2014-02-01

    Full Text Available This paper proposes a Parallel Guided Local Search (PGLS framework for continuous optimization. In PGLS, several guided local search (GLS procedures (agents are run for solving the optimization problem. The agents exchan ge information for speeding up the search. For example, the information exchanged could be kno wledge about the landscape obtained by the agents. The proposed algorithm is applied to co ntinuous optimization problems. The preliminary experimental results show that the algo rithm is very promising .

  17. Neolithic plant use in the western Mediterranean region: preliminary results from the AGRIWESTMED Project

    OpenAIRE

    Peña-Chocarro, Leonor; Pérez Jordá, Guillem; Morales Mateos, Jacob; Zapata, Lydia

    2013-01-01

    This contribution focuses on the preliminary results of the AGRIWESTMED project which focuses on the archaeobotanical analyses of early Neolithic sites in the western Mediterranean region (both in Iberia and in northern Morocco). A large number of sites has been studied producing an interesting dataset of plant remains which places the earliest examples of domesticated plants in the second half of the 6th millennium cal BC. Plant diversity is high as it is shown by the large number o...

  18. Preliminary results and analyses of using IGS GPS data to determine global ionospheric TEC

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Using the spherical harmonic (SH) function model and the dual frequency GPS data of 139 International GPS Service (IGS) stations for July 15 of 2000, the global ionospheric total electron content (TEC) is calculated and the basic method is investigated. Here, preliminary results are reported and the problems and difficulties to be solved for using GPS data to determine the global ionospheric TEC are discussed.

  19. Holocene evolution and sedimentation rate of Alikes Lagoon, Zakynthos island, Western Greece – preliminary results

    OpenAIRE

    P. Avramidis; N. Kontopoulos

    2009-01-01

    In the present study we present preliminary results of Zakynthos Alikes lagoon, which is one of the most seismically active regions of Greece. In order to estimate – interpret the Holocene evolution of the area and to reconstruct the palaeonvironmental changes, we based on the data of a 21 m sediment core. Sediment types, structure, colour, as well as contact depths and bed characteristics, were recorded in the field. Standarised sedimentological analysis were carried out, on 46 samples inclu...

  20. Investigation of polarized-proton target materials by differential calorimetry: preliminary results

    International Nuclear Information System (INIS)

    A simple differential calorimeter was designed and operated for an investigation of the thermodynamic properties of polarized target materials. The calibration and use of the calorimeter are discussed, after a brief exposition of our motivation for this work. The results of a preliminary study of target materials is presented with emphasis on the relevance of the glass state to dynamic polarization in chemically-doped targets

  1. Trends in the Utilization of Brachytherapy in Cervical Cancer in the United States

    International Nuclear Information System (INIS)

    Purpose: To determine the trends in brachytherapy use in cervical cancer in the United States and to identify factors and survival benefits associated with brachytherapy treatment. Methods and Materials: Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified 7359 patients with stages IB2-IVA cervical cancer treated with external beam radiation therapy (EBRT) between 1988 and 2009. Propensity score matching was used to adjust for differences between patients who received brachytherapy and those who did not from 2000 onward (after the National Cancer Institute alert recommending concurrent chemotherapy). Results: Sixty-three percent of the 7359 women received brachytherapy in combination with EBRT, and 37% received EBRT alone. The brachytherapy utilization rate has decreased from 83% in 1988 to 58% in 2009 (P<.001), with a sharp decline of 23% in 2003 to 43%. Factors associated with higher odds of brachytherapy use include younger age, married (vs single) patients, earlier years of diagnosis, earlier stage and certain SEER regions. In the propensity score-matched cohort, brachytherapy treatment was associated with higher 4-year cause-specific survival (CSS; 64.3% vs 51.5%, P<.001) and overall survival (OS; 58.2% vs 46.2%, P<.001). Brachytherapy treatment was independently associated with better CSS (hazard ratio [HR], 0.64; 95% confidence interval [CI], 0.57-0.71), and OS (HR 0.66; 95% CI, 0.60 to 0.74). Conclusions: This population-based analysis reveals a concerning decline in brachytherapy utilization and significant geographic disparities in the delivery of brachytherapy in the United States. Brachytherapy use is independently associated with significantly higher CSS and OS and should be implemented in all feasible cases

  2. Procedures for calibration of brachytherapy sources

    International Nuclear Information System (INIS)

    Brachytherapy source strength verification is a responsibility of the user of these source, in fact of the Medical Physicists in charge of this issue in a Radiotherapy Service. The calibration procedures in the users conditions are shown. Specifics methods for source strength determination are recommended, both for High Dose Rate (HDR) sources with Remote Afterloading equipment and for Low Dose Rate sources. The The results of the calibration of HDR Remote After loaders are indicated

  3. Most significant preliminary results of the probabilistic safety analysis on the Juragua nuclear power plant

    International Nuclear Information System (INIS)

    Since 1990 the Group for PSA Development and Applications (GDA/APS) is working on the Level-1 PSA for the Juragua-1 NPP, as a part of an IAEA Technical Assistance Project. The main objective of this study, which is still under way, is to assess, in a preliminary way, the Reactor design safety to find its potential 'weak points' at the construction stage, using a eneric data base. At the same time, the study allows the PSA team to familiarize with the plant design and analysis techniques for the future operational PSA of the plant. This paper presents the most significant preliminary results of the study, which reveal some advantages of the safety characteristics of the plant design in comparison with the homologous VVER-440 reactors and some areas, where including slight modifications would improve the plant safety, considering the level of detail at which the study is carried out. (author). 13 refs, 1 fig, 2 tabs

  4. Intra coronary brachytherapy

    International Nuclear Information System (INIS)

    Despite the initial promise of vasculopathy intervention restenosis- a consequence of the (normal) would healing process-has emerged as a major problem. Angiographic restenosis has been reported in 40-60% of patients after successful P TCA. The basic mechanism of restenosis, (acute recoil, negative remodeling and neo intimal hyperplasia), are only partially counteracted by endovascular prosthetic devices (s tents). The rate of in-s tent restenosis, which is primarily caused by neo intimal hyperplasia due to the (micro) trauma of the arterial wall by the s tent struts, has been reduced to 18-32%. Ionizing (beta or gamma) radiations has been established as a potent treatment for malignant disorders. In recent years, there has also been increasing interest among clinicians in the management of benign lesions with radiation. Over the past several years, there has been a growing body of evidence that endovascular brachytherapy has a major impact on the biology of the restenosis. It must be underlined that understanding the biology and pathophysiology of restenosis and assessing various treatment options should preferably be a team effort, with the three gracesbeing interventional cardiologist, nuclear oncologist, and industrial partners. The vast amount of data in over 20000 patients from a wide range of randomized controlled trials, has shown that brachytherapy is the only effective treatment for in-s tent restenosis. We are learning more and more about how to improve brachytherapy. While the new coated s tents that we heard about today is fascinating and extremely promising, brachytherapy still has a very important place in difficult patients, such as those with total occlusions, osti al lesions, left main lesions, multivessel disease and diabetes. Regarding to above mentioned tips, we (a research team work, in the Nuclear Research Center Of the Atomic Energy Organization Of Iran), focused on synthesis and preparation of radioactive materials for use in I c-B T. We

  5. Brachytherapy treatment with high dose rate

    International Nuclear Information System (INIS)

    Retrospectively analyze results and prognostic factors of cervical cancer patients treated with radio concomitant cisplatin-based chemotherapy, radiation therapy combined modality. Methods: From January 2003 to December 2007, 198 patients with invasive cervical cancer were treated at the Oncology Department of Hospital Robau Celestino Hernandez (brachytherapy performed at INOR). The most common age group was 31 to 40 years. The histology in squamous cell carcinoma accounted for 84.3% of cases. The treatment consisted of external pelvic irradiation and vaginal brachytherapy, high dose rate. Concomitant chemotherapy consisted of cisplatin 40 mg/m2 weekly with a maximum of 70 mg for 5 weeks. Results: 66.2% of patients completed 5 cycles of chemotherapy. The median overall survival was 39 months, overall survival, disease-free survival and survival free of locoregional recurrence at 5 years of 78%, 76% and 78.6% respectively .. We found that clinical stage, histological type (adenocarcinoma worst outcome) were statistically related to level of response. Conclusions: Treatment with external pelvic radiation, brachytherapy and concurrent weekly cisplatin in patients with stage IIIB cervical cancer is feasible in the Chilean public health system, well tolerated and results comparable to international literature. (Author)

  6. Sexual function after permanent prostate brachytherapy

    International Nuclear Information System (INIS)

    Purpose: To determine the incidence of potency preservation following permanent prostate brachytherapy and to evaluate the effect of multiple clinical and treatment parameters on penile erectile function. Materials and Methods: 425 patients underwent permanent prostate brachytherapy from April 1995 to October 1999. 209 patients who were potent prior to brachytherapy and currently not receiving hormonal manipulation were mailed an International Index of Erectile Function (IIEF) questionnaire with a pre-addressed stamped envelope. 180 patients completed and returned the questionnaire. Median patient follow-up was 39 months (range 18-74 months). Pre-implant erectile function was assigned using a three-tiered scoring system (2 = erections always or nearly always sufficient for vaginal penetration; 1 = erections sufficient for vaginal penetration but considered suboptimal; 0 = the inability to obtain erections and/or erections inadequate for vaginal penetration). Post-implant potency was defined as an IIEF score >11. Clinical parameters evaluated for sexual function included patient age, clinical T stage, elapsed time since implantation, hypertension, diabetes mellitus, and tobacco consumption. Evaluated treatment parameters included the utilization of neoadjuvant hormonal manipulation and the choice of isotope. The efficacy of sildenafil citrate in brachytherapy induced erectile dysfunction (ED) was also evaluated. Results: A pre-treatment erectile function score of 2 and 1 were assigned to 126 and 54 patients respectively. With 6 year follow up, 39% of patients maintained potency following prostate brachytherapy with a plateau on the curve. Post-implant preservation of potency (IIEF>11) correlated with pre-implant erectile function (50% versus 14% for pre-implant scores of 2 and 1 respectively, p≤0.0001), patient age (56%, 38%, and 23% for patients <60 years of age, 60-69 years of age, and ≥70 years of age respectively, p=0.012) and a history of diabetes mellitus

  7. Erectile Function Durability Following Permanent Prostate Brachytherapy

    International Nuclear Information System (INIS)

    Purpose: To evaluate long-term changes in erectile function following prostate brachytherapy. Methods and Materials: This study included 226 patients with prostate cancer and preimplant erectile function assessed by the International Index of Erectile Function-6 (IIEF-6) who underwent brachytherapy in two prospective randomized trials between February 2001 and January 2003. Median follow-up was 6.4 years. Pre- and postbrachytherapy potency was defined as IIEF-6 ≥ 13 without pharmacologic or mechanical support. The relationship among clinical, treatment, and dosimetric parameters and erectile function was examined. Results: The 7-year actuarial rate of potency preservation was 55.6% with median postimplant IIEF of 22 in potent patients. Potent patients were statistically younger (p = 0.014), had a higher preimplant IIEF (p < 0.001), were less likely to be diabetic (p = 0.002), and were more likely to report nocturnal erections (p = 0.008). Potency preservation in men with baseline IIEF scores of 29-30, 24-28, 18-23, and 13-17 were 75.5% vs. 73.6%, 51.7% vs. 44.8%, 48.0% vs. 40.0%, and 23.5% vs. 23.5% in 2004 vs. 2008. In multivariate Cox regression analysis, preimplant IIEF, hypertension, diabetes, prostate size, and brachytherapy dose to proximal penis strongly predicted for potency preservation. Impact of proximal penile dose was most pronounced for men with IIEF of 18-23 and aged 60-69. A significant minority of men who developed postimplant impotence ultimately regained erectile function. Conclusion: Potency preservation and median IIEF scores following brachytherapy are durable. Thoughtful dose sparing of proximal penile structures and early penile rehabilitation may further improve these results.

  8. Ion currents and energies in reactive low-voltage ion plating: preliminary results

    Science.gov (United States)

    Edlinger, Johannes P.; Pulker, Hans K.

    1990-12-01

    Reactive Low-Voltage Ion Plating (RLVIP) is a plasma-assisted evaporation process that produces anorganic oxide- and nitride films with a closed microstructure. in order to better understand the process and the resulting film properties a BALZERS PPM 400 Plasmamonitor, a combination of a quadrupole mass filter and an energy selective ion optics, has been used to study the relative abundancies and energy distributions of the ions impinging on the growing film in the RLVIP process. The device is discussed and preliminary results are presented: The plasma is anisotropic. Surprisingly it contains ions with higher energies than expected from the self-bias potential.

  9. [Preliminary results of lymphatic chemotherapy in the treatment of rectal cancer].

    Science.gov (United States)

    Narvuzov, S N; Zkbarov, E T; Abduzhabborov, S B; Khakimov, A M; Bobokulov, Kh B; Sidikov, U R

    2004-03-01

    Preliminary results of treatment of 28 patients with cancer recti, in whom lymphatic chemotherapy was applied and operative intervention as well, were studied. The results of treatment in control group, consisting of 28 patients, to whom neoadjuvant systemic chemotherapy was conducted, are adduced. Comparative analysis performed have shown that general toxic signs occurred three times lesser in patients of the main group, than in a control one; the postoperative complications was two times lesser. In one-year follow-up in the main group the recurrences and metastases were absent, in a control group the tumor recurrence had occurred in 3 (10%) of patients. PMID:15154248

  10. Radon and radon daughters' concentration in spring and wells waters from Presidente Prudente: preliminary results

    International Nuclear Information System (INIS)

    This work presents the preliminary results about the concentration of radon and radon daughters in wells and springs water from Presidente Prudente. Six water samples were studied: three from well-water, two from springs water and one from potable water. For the determination of α-activity the samples were placed inside plastic containers where the CR-39 tracks detectors were outside the water. The track density of α-particles were measured by using optical microscopy. The results show that one sample from well-water presented higher concentration of radon and radon daughters than the other samples. (author)

  11. Preliminary results of the large experimental wind turbine phase of the national wind energy program

    Science.gov (United States)

    Thomas, R. L.; Sholes, T.; Sholes, J. E.

    1975-01-01

    The preliminary results of two projects in the development phase of reliable wind turbines designed to supply cost-competitive electrical energy were discussed. An experimental 100 kW wind turbine design and its status are first reviewed. The results of two parallel design studies for determining the configurations and power levels for wind turbines with minimum energy costs are also discussed. These studies predict wind energy costs of 1.5 to 7 cents per kW-h for wind turbines produced in quantities of 100 to 1000 per year and located at sites having average winds of 12 to 18 mph.

  12. Some preliminary photometric results of QSOs useful for the link between future Gaia CRF and ICRF

    Science.gov (United States)

    Damljanovic, G.; Taris, F.; Boeva, S.

    2015-08-01

    Gaia was launched in December 2013 as cornerstone mission of the European Space Agency (ESA). It is going to map the entire sky (over one billion stars) and more than 500,000 quasars (QSOs); all objects with apparent V band magnitudes in the range 5.6 Serbia). Some preliminary photometric results are presented as a part of astrophotometric and astrophysical investigations of ERS in the framework of the reference systems. Also, some photometric results following from the data obtained by using the TJO (Telescopi Juan Oro, D = 0.8 m) in OAdM (Observatori Astronomic del Montsec, Spain) are presented.

  13. Brachytherapy- past, present and future

    International Nuclear Information System (INIS)

    Discovery of radioactivity by Henry Becquerel and radium by Madame and Pierre Curie was probably the greatest event of 19th century in the field of medical science. Radium was used for brachytherapy as early as 1901. Today almost every organ is amenable to brachytherapy procedure. High dose rate remote afterloading systems have increased the patients comfort and complete radiation protection to the staff during treatment. Computers have not only improved the precision of treatment but also made 3 D conformal brachytherapy possible. As the goal of cancer management is changing from just life preservation to organ and function preservation without compromising cure rate, the role of brachytherapy is becoming more and more prominent. Intensive efforts will be needed to meet with the future challenges. (author). 13 refs

  14. Dosimetry in high dose rate endoluminal brachytherapy

    International Nuclear Information System (INIS)

    In endoluminal brachytherapy for the tracheobronchial tree, esophagus, and bile duct, a reference point for dose calculation has been often settled at 1 cm outside from the middle of source travel path. In the current study, a change in the ratio of the reference point dose on the convex to concave side (Dq/Dp) was calculated, provided the source travel path bends as is the case in most endoluminal brachytherapies. Point source was presumed to move stepwise at 1 cm interval from 4 to 13 locations. Retention time at each location was calculated by personal computer so as to deliver equal dose at 1 cm from the linear travel path. With the retention time remaining constant, the change of Dq/Dp was assessed by bending the source travel path. Results indicated that the length of the source travel path and radius of its curve influenced the pattern of change in Dq/Dp. Therefore, it was concluded that the difference in reference dose on the convex and concave side of the curved path is not negligible under certain conditions in endoluminal brachytherapy. In order to maintain the ratio more than 0.9, relatively greater radius was required when the source travel path was decreased. (author)

  15. Radioactive seed immobilization techniques for interstitial brachytherapy

    Energy Technology Data Exchange (ETDEWEB)

    Yan, K.; Podder, T.; Buzurovic, I.; Hu, Y.; Dicker, A.; Valicenti, R.; Yu, Y. [Thomas Jefferson University, Department of Radiation Oncology, Philadelphia, PA (United States); Messing, E. [University of Rochester, Departments of Urology and Surgery, Rochester, NY (United States); Rubens, D. [University of Rochester, Departments of Imaging Science and Surgery, Rochester, NY (United States); Sarkar, N. [Vanderbilt University, Department of Mechanical Engineering, Nashville, TN (United States); Ng, W. [Nangyang Technical University, School of Mechanical and Aerospace Engineering, Singapore (Singapore)

    2008-06-15

    In prostate brachytherapy, seeds can detach from their deposited sites and move locally in the pelvis or migrate to distant sites including the pulmonary and cardiac regions. Undesirable consequences of seed migration include inadequate dose coverage of the prostate and tissue irradiation effects at the site of migration. Thus, it is clinically important to develop seed immobilization techniques. We first analyze the possible causes for seed movement, and propose three potential techniques for seed immobilization: (1) surgical glue, (2) laser coagulation and (3) diathermy coagulation. The feasibility of each method is explored. Experiments were carried out using fresh bovine livers to investigate the efficacy of seed immobilization using surgical glue. Results have shown that the surgical glue can effectively immobilize the seeds. Evaluation of the radiation dose distribution revealed that the non-immobilized seed movement would change the planned isodose distribution considerably; while by using surgical glue method to immobilize the seeds, the changes were negligible. Prostate brachytherapy seed immobilization is necessary and three alternative mechanisms are promising for addressing this issue. Experiments for exploring the efficacy of the other two proposed methods are ongoing. Devices compatible with the brachytherapy procedure will be designed in future. (orig.)

  16. New Brachytherapy Standards Paradigm Shift

    International Nuclear Information System (INIS)

    The absorbed dose to water rate at short distances in water is the quantity of interest for dosimetry in radiotherapy, but no absorbed dose to water primary standards have been available to date for dosimetry of brachytherapy sources. Currently, the procedures to determine the absorbed dose imparted to the patient in brachytherapy treatments are based on measurements traceable to air kerma standards. These procedures are affected by an uncertainty that is larger than the limit recommended by the IAEA dosimetry protocol (IAEA TRS 398 (2000)). Based on this protocol, the goal for the uncertainty of the dose delivered to the target volume should be within 5% (at the level of one standard deviation) to assure the effectiveness of a radiotherapy treatment. The international protocols for the calibration of brachytherapy gamma ray sources are based on the reference air kerma rate or the air kerma strength. The absorbed dose to water, in water at the reference position around a brachytherapy source is then calculated by applying the formalism of the protocols based on a conversion constant, the dose rate constant Λ, specific for the characteristics and geometry of the brachytherapy source. The determination of this constant relies on Monte Carlo simulations and relative measurements performed with passive dosimeters, and therefore it is typically affected by large uncertainties, larger than 5% (at the level of one standard deviation). The conversion procedure needed for brachytherapy dosimetry is a source of additional uncertainty on the final value of the absorbed dose imparted to the patient. It is due to a lack of metrology standards that makes dosimetry of brachytherapy sources less accurate than dosimetry of external radiation beams produced by 60Co sources and accelerators currently used in external beam radiotherapy. This paper reviews the current developments of absorbed dose to water primary standards for brachytherapy and the rationale for the choice of the

  17. 75 FR 65449 - Stainless Steel Bar From India: Extension of Time Limit for the Preliminary Results of the...

    Science.gov (United States)

    2010-10-25

    ... International Trade Administration Stainless Steel Bar From India: Extension of Time Limit for the Preliminary... Revocation in Part, 75 FR 15679 (March 30, 2010). The preliminary results for this administrative review are... duty order on stainless steel bar from India covering the period February 1, 2009, through January...

  18. Brachytherapy in childhood rhabdomyosarcoma treatment

    International Nuclear Information System (INIS)

    A retrospective study of 21 children with rhabdomyosarcoma treated by brachytherapy to the primary site of the tumor at the Radiotherapy Department of the A.C.Camargo Hospital between january/1980 to june/1993 was undertaken. The main objectives were to comprove the utility of brachytherapy in childhood rhabdomyosarcoma, to evaluate the local control and survival, in association with chemotherapy, to analyze the late effects of the treatment and to determinate the preferential technique to each clinical situation. All patients received brachytherapy to the tumor site. The radioactive isotopes employed were Gold198, Cesium137 and Iridium192. The brachytherapy techniques depended on the tumor site, period of treatment, availability of the radioactive material and stage of the disease. Patients treated exclusively by brachytherapy received 40 Gy to 60 Gy. When brachytherapy was associated with external radiotherapy the dose ranged from 20 Gy to 40 Gy. Local control was achieved in 18 of 20 patients (90%). The global survival and local control survival rates were 61.9% (13/21 patients) and 72,2% (13/18 patients) respectively. (author)

  19. Construction balance analysis of dose rate medium brachytherapy TDS

    International Nuclear Information System (INIS)

    One of the most important part of brachytherapy instrument design activities is analyze by determining the centroid point of construction in order to maintain the balance of brachytherapy instrument, either during operation as well as when transported. Operation of brachytherapy is not only done in one place so it is necessary to balance the analysis of the forces at the time did not move, moved on the horizontal floor and sloping floor. Calculation approach who is done to calculate the weight of mechanical components on each module, and then calculate the centroid of each module, for the balance of forces analysis performed with the assumption at the time of brachytherapy in the position of not moving on a horizontal floor, moved from a place to another on the horizontal floor and on the floor with sloping angle 30°. Base on the results of this analysis are expected to balance the four wheels can move without slipping at the time of decline or incline. Also, results of analysis can be used in designing a mobile construction brachytherapy taking into consideration the aesthetic ideal, easy to operate, ensure the safety of equipment, operator and patient. (author)

  20. Hybridization among wild boars, local breeds and commercial breeds - preliminary results

    DEFF Research Database (Denmark)

    Iacolina, Laura; Bakan, Jana; Cubric-Curik, Vlatka;

    2016-01-01

    . Hybridization with the domestic pig is known to occur in Europe, however the degree and extent of the phenomenon is not fully understood yet. Introgression is considered to be a treat to biodiversity and could lead to loss of local adaptation or introgression in the wild population of human selected genes. A...... gradients in variability levels among the analysed wild and domestic populations. This preliminary results will be further investigated to address the possible presence of hybrid zone(s) in Europe and the possible implications for conservation and management of both wild populations and local pig breeds, as...

  1. UAS Integration into the NAS: iHTL: DAA Display Evaluation Preliminary Results

    Science.gov (United States)

    Fern, Lisa; Rorie, Conrad; Shively, Jay

    2014-01-01

    The integrated human-in-the-loop (iHITL) simulation examined the effect of four different Detect-and-Avoid (DAA) display concepts on unmanned aircraft system (UAS) pilots' ability to maintain safe separation. The displays varied in the type and amount of guidance they provided to pilots. The study's background and methodology are discussed, followed by a presentation of the preliminary 'measured response' data (i.e., pilots' end-to-end response time in reacting to traffic alerts on their DAA display). Results indicate that display type had moderate to no affect on pilot measured response times.

  2. MISSE-7 MESA Miniaturized Electrostatic Analyzer - Ion Spectra Analysis Preliminary Results

    Science.gov (United States)

    Enloe, C. L.; Balthazor, R. L.; McHarg, M. G.; Clark, A. L.; Waite, D.; Wallerstein, A. J.; Wilson, K. A.

    2011-12-01

    The 7th Materials on the International Space Station Experiment (MISSE-7) was launched in November 2009 and retrieved on STS-134 in April 2011. One of the onboard experiments, the Miniaturized Electrostatic Analyzer (MESA), is a small low-cost low-size/weight/power ion and electron spectrometer that was pointed into ram during the majority of the time onboard. Over 800 Mb of data has been obtained by taking spectra every three minutes on-orbit. The data has been analyzed with a novel "parameterizing the parameters" method suitable for on-orbit data analysis using low-cost microcontrollers. Preliminary results are shown.

  3. Pyrolysis process for treatment of automobile shredder residue: preliminary experimental results

    Energy Technology Data Exchange (ETDEWEB)

    Galvagno, S.; Fortuna, F.; Cornacchia, G.; Casu, S.; Coppola, T.; Sharma, V.K. [ENEA C.R. Trisaia, AMB-TEIN-RIF Unit, Policoro (Italy)

    2001-03-01

    The main objective of the present research work is to evaluate both the process performances and characteristics of the products obtained from the treatment of automobile shredder residue (ASR) using pilot scale experimental pyrolysis plant operating under different load and varying process temperatures. ASR samples used for the treatment, solid and liquid by-products obtained and syngas produced were analysed both through on-line monitoring (gas) and laboratory analysis. Brief descriptions of the plant as well as the preliminary experimental results obtained are presented here. (Author)

  4. Preliminary Results of Ion Beam Extraction Tests on EAST Neutral Beam Injector

    Institute of Scientific and Technical Information of China (English)

    胡纯栋

    2012-01-01

    The neutral beam injection (NBI) system is one of the most important auxiliary plasma heating and current driving methods for fusion device. A high power ion beam of 3 MW with 80 keV beam energy in 0.5 s beam duration and a long pulse ion beam of 4 s with 50 keV beam energy ion beam extraction were achieved on the EAST neutral beam injector on the teststand. The preliminary results show that the EAST-NBI system was developed successfully on schedule.

  5. VNIIEF-ORNL Joint Plutonium Measurements with NMIS and Results of Plutonium Attributes Preliminary Evaluations

    International Nuclear Information System (INIS)

    Within the frameworks of TO No.007 between ORNL and VNIIEF on Nuclear Materials Identification System (NMIS) mastering at VNIIEF in July 2000 there had been finalized joint measurements, in which NMIS-technique equipment was used that had been placed at VNIIEF's disposal by ORNL, as well as VNIIEF-produced unclassified samples of fissile materials. In the report there are presented results of experimental data preliminary processing to obtain absolute values of some attributes used in plutonium shells measurements: values of their mass and thickness. Possibility of fissile materials parameters absolute values obtaining from measurement data essentially widens NMIS applicability to the tasks relevant to these materials inspections

  6. Preliminary results of Lean method implementation in a pathology lab from Northeastern Brazil

    Directory of Open Access Journals (Sweden)

    Josiane S. Quetz

    2015-02-01

    Full Text Available Oncologic care shows a growing and unmet demand, and requires the search for alternatives that allow the efficient use of limited resources, the building of autonomy, and the endeavour for continuous improvement of processes. In the present work, we present the implementation of Lean philosophy at a pathology laboratory of an oncology hospital. Among the preliminary results, we highlight the redefinition of the dynamics of the staff, and the physical reorganization of the area. Such important changes culminated in an expressive reduction of lead time, even with a significant increase in the monthly load of exams.

  7. Postmortem study of stable carbon isotope ratios in human cerebellar DNA: preliminary results

    International Nuclear Information System (INIS)

    It is observed that 13C/12C ratios in tissue specimens removed postmortem in the United States and Canada are significantly different from corresponding ratios in European specimens. On the basis of this information, measurements of carbon isotope ratios in DNA isolated from cerebella of native-born and European-born North Americans are in progress with the goal of estimating the average lifetime rate of DNA turnover in human neurons. Preliminary results from twenty postmortem examinations are consistent with the hypothesis that a significant proportion of human cerebellar DNA is renewed during the lifetime of an individual

  8. Preliminary Results from Small-Pixel CdZnTe and CdTe Arrays

    Science.gov (United States)

    Ramsey, B. D.; Sharma, D. P.; Meisner, J.; Austin, R. A.

    1999-01-01

    We have evaluated 2 small-pixel (0.75 mm) Cadmium-Zinc-Telluride arrays, and one Cadmium-Telluride array, all fabricated for MSFC by Metorex (Finland) and Baltic Science Institute (Riga, Latvia). Each array was optimized for operating temperature and collection bias. It was then exposed to Cadmium-109 and Iron-55 laboratory isotopes, to measure the energy resolution for each pixel and was then scanned with a finely-collimated x-ray beam, of width 50 micron, to examine pixel to pixel and inter-pixel charge collections efficiency. Preliminary results from these array tests will be presented.

  9. Preliminary results of mental workload and task engagement assessment using electroencephalogram in a space suit.

    Science.gov (United States)

    Rabbi, Ahmed F; Zony, Abongwa N; de Leon, Pablo; Fazel-Rezai, Reza

    2012-01-01

    In this paper, we present preliminary results of subject's mental workload and task engagement assessment in an experimental space suit. We have quantified the mental workload and task engagement based on changes in electroencephalogram (EEG). EEG signals were collected from subjects scalp using a commercial wireless EEG device in two experimental conditions - when subjects did not wear space suit (control condition) and when subjects wore space suit. Brain state changes were estimated and compared with the direct responses for different tasks and different conditions. We found that the spacesuit experiment introduced a greater mental workload where subject's stress levels were higher than control experiment. PMID:23366693

  10. Long-Term Results of a Prospective, Phase II Study of Long-Term Androgen Ablation, Pelvic Radiotherapy, Brachytherapy Boost, and Adjuvant Docetaxel in Patients With High-Risk Prostate Cancer

    International Nuclear Information System (INIS)

    Purpose: We report the long-term results of a prospective, Phase II study of long-term androgen deprivation (AD), pelvic radiotherapy (EBRT), permanent transperineal prostate brachytherapy boost (PB), and adjuvant docetaxel in patients with high-risk prostate cancer. Methods and Materials: Eligibility included biopsy-proven prostate adenocarcinoma with the following: prostate-specific antigen (PSA) > 20 ng/ml; or Gleason score of 7 and a PSA >10 ng/ml; or any Gleason score of 8 to 10; or stage T2b to T3 irrespective of Gleason score or PSA. Treatment consisted of 45 Gy of pelvic EBRT, followed 1 month later by PB with either iodine-125 or Pd-103. One month after PB, patients received three cycles of docetaxel chemotherapy (35 mg/m2 per week, Days 1, 8, and 15 every 28 days). All patients received 2 years of AD. Biochemical failure was defined as per the Phoenix definition (PSA nadir + 2). Results: From August 2000 to March 2004, 42 patients were enrolled. The median overall and active follow-ups were 5.6 years (range, 0.9-7.8 years) and 6.3 years (range, 4-7.8 years), respectively. Grade 2 and 3 acute genitourinary (GU) and gastrointestinal (GI) toxicities were 50.0% and 14.2%, respectively, with no Grade 4 toxicities noted. Grade 3 and 4 acute hematologic toxicities were 19% and 2.4%, respectively. Of the patients, 85.7% were able to complete the planned multimodality treatment. The 5- and 7-year actuarial freedom from biochemical failures rates were 89.6% and 86.5%, and corresponding rates for disease-free survival were 76.2% and 70.4%, respectively. The 5- and 7-year actuarial overall survival rates were 83.3% and 80.1%, respectively. The 5- and 7-year actuarial rates of late Grade 2 GI/GU toxicity (no Grade 3-5) was 7.7%. Conclusions: The trimodality approach of using 2 years of AD, external radiation, brachytherapy, and upfront docetaxel in high-risk prostate cancer is well tolerated, produces encouraging long-term results, and should be validated in a multi

  11. Interstitial high-dose-rate brachytherapy in the treatment of base of tongue carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Takacsi-Nagy, Z.; Polgar, C.; Somogyi, A.; Major, T.; Fodor, J.; Nemeth, G. [Dept. of Radiotherapy, National Inst. of Oncology, Budapest (Hungary); Oberna, F. [Dept. of Maxillofacial Surgery, St. Rokus Hospital, Budapest (Hungary); Remenar, E.; Kasler, M. [Dept. of Head and Neck, Maxillofacial and Reconstructive Plastic Surgery, National Inst. of Oncology, Budapest (Hungary)

    2004-12-01

    Background and purpose: to date none of the studies examined the feasibility and efficacy of interstitial high-dose-rate (HDR) brachytherapy in the treatment of carcinoma of the tongue base. Therefore the aim of this study was to contribute to this issue. Patients and methods: between 1992 and 2000 37 patients (mean age 55 years) with T1-4 and NO-3 carcinoma of the base of tongue were presented. Neck dissection was carried out in twelve cases (32%). 30 patients with advanced stage received brachytherapy boost after 50-66.5 Gy (mean, 60 Gy) locoregional external beam irradiation (EBI) and 7 patients with early stage (T1-2, NO) were managed locally with wide tumor excision and sole brachytherapy. 4 of them underwent neck dissection and the others were subjected to 50 Gy regional EBI. The mean dose of boost and sole brachytherapy was 18 Gy and 28 Gy, respectively. Results: the median follow-up time for surviving patients was 51 months. The 7 sole brachytherapy patients are living with no evidence of disease. For patients treated with EBI and brachytherapy boost, the 5-year actuarial rate of local, locoregional recurrence-free and overall survival was 60%, 52% and 46%, respectively. For all patients in univariate analysis larger tumor size (T4 vs. T1-3) was significant negative predictor of local (RR: 7.23) and locoregional control (RR: 3.87), but nodal involvement was not. Delayed soft tissue ulceration and osteoradionecrosis occurred in 4 (13%) EBI and brachytherapy treated patients. None of the sole brachytherapy patients experienced severe late radiation toxicity. Conclusion: EBI combined with interstitial HDR brachytherapy boost result in acceptable local tumor control with low incidence of late side effects in patients with advanced disease. Fractionated sole HDR brachytherapy following tumor excision is a feasible treatment option for patients with early stage cancer and gives excellent local results. (orig.)

  12. Brachytherapy with an improved MammoSite Radiation Therapy System

    Science.gov (United States)

    Karthik, Nanda; Keppel, Cynthia; Nazaryan, Vahagn

    2007-03-01

    Accelerated partial breast irradiation treatment utilizing the MammoSite Radiation Therapy System (MRTS) is becoming increasingly popular. Clinical studies show excellent results for disease control and localization, as well as for cosmesis. Several Phase I, II, and III clinical trials have found significant association between skin spacing and cosmetic results after treatment with MRTS. As a result, patients with skin spacing less then 7 mm are not recommended to undergo this treatment. We have developed a practical innovation to the MammoSite brachytherapy methodology that is directed to overcome the skin spacing problem. The idea is to partially shield the radiation dose to the skin where the skin spacing is less then 7 mm, thereby protecting the skin from radiation damage. Our innovation to the MRTS will allow better cosmetic outcome in breast conserving therapy (BCT), and will furthermore allow more women to take advantage of BCT. Reduction in skin radiation exposure is particularly important for patients also undergoing adjuvant chemotherapy. We will present the method and preliminary laboratory and Monte Carlo simulation results.

  13. Dissolved air flotation for treating wastewater of the nuclear industry. Preliminary results

    International Nuclear Information System (INIS)

    Preliminary testing of dissolved air flotation (DAF) for wastewater treatment is presented. A combined coagulation-flocculation/DAF column system is used to remove oil and 60Co from nuclear industry wastewater. In this work, operational conditions and coagulant/flocculant concentrations are optimized by varying pH. Determinations of air-solids ratio (G/S), retention time (θ), pressure (P), volume of depressurized air-water mixture (V), turbidity and 60Co concentrations are reported. The effect of the treatment on the efficiency of separation of oily residues is also discussed. The results establish that the coagulant/flocculant system, formed by a modified polyamine (25 mgL-1) and a slightly cationic polyacrylamide (1.5 mgL-1), under specific operational conditions (pH = 7, mixing intensity Im1 = 300 s-1 and Im2 = 30 s-1), allowed the destabilization of colloidal matter, resulting in resistant flocs. It was concluded that by using G/S = 0.3, θ = 15 min, P = 620 kPa and V = 0.0012 m3, the greatest percentage removals of oil, turbidity, total cobalt and 60Co were obtained. These preliminary results then show that dissolved air flotation represents a good alternative for treatment of nuclear industry wastewater contaminated with radionuclides. (author)

  14. Utilization and Outcomes of Breast Brachytherapy in Younger Women

    International Nuclear Information System (INIS)

    Purpose: To directly compare (1) radiation treatment utilization patterns; (2) risks of subsequent mastectomy; and (3) costs of radiation treatment in patients treated with brachytherapy versus whole-breast irradiation (WBI), in a national, contemporary cohort of women with incident breast cancer, aged 64 years and younger. Methods and Materials: Using MarketScan health care claims data, we identified 45,884 invasive breast cancer patients (aged 18-64 years), treated from 2003 to 2010 with lumpectomy, followed by brachytherapy (n=3134) or whole-breast irradiation (n=42,750). We stratified patients into risk groups according to age (Age<50 vs Age≥50) and endocrine therapy status (Endocrine− vs Endocrine+). “Endocrine+” patients filled an endocrine therapy prescription within 1 year after lumpectomy. Pathologic hormone receptor status was not available in this dataset. In brachytherapy versus WBI patients, utilization trends and 5-year subsequent mastectomy risks were compared. Stratified, adjusted subsequent mastectomy risks were calculated using proportional hazards regression. Results: Brachytherapy utilization increased from 2003 to 2010: in patients Age<50, from 0.6% to 4.9%; patients Age≥50 from 2.2% to 11.3%; Endocrine− patients, 1.3% to 9.4%; Endocrine+ patients, 1.9% to 9.7%. Age influenced treatment selection more than endocrine status: 17% of brachytherapy patients were Age<50 versus 32% of WBI patients (P<.001); whereas 41% of brachytherapy patients were Endocrine–versus 44% of WBI patients (P=.003). Highest absolute 5-year subsequent mastectomy risks occurred in Endocrine−/Age<50 patients (24.4% after brachytherapy vs 9.0% after WBI (hazard ratio [HR] 2.18, 95% confidence interval [CI] 1.37-3.47); intermediate risks in Endocrine−/Age≥50 patients (8.6% vs 4.9%; HR 1.76, 95% CI 1.26-2.46); and lowest risks in Endocrine+ patients of any age: Endocrine+/Age<50 (5.5% vs 4.5%; HR 1.18, 95% CI 0.61-2.31); Endocrine+/Age≥50 (4.2% vs 2

  15. Utilization and Outcomes of Breast Brachytherapy in Younger Women

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Grace L. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Huo, Jinhai [Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Giordano, Sharon H. [Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Hunt, Kelly K. [Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Buchholz, Thomas A. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Smith, Benjamin D., E-mail: bsmith3@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2015-09-01

    Purpose: To directly compare (1) radiation treatment utilization patterns; (2) risks of subsequent mastectomy; and (3) costs of radiation treatment in patients treated with brachytherapy versus whole-breast irradiation (WBI), in a national, contemporary cohort of women with incident breast cancer, aged 64 years and younger. Methods and Materials: Using MarketScan health care claims data, we identified 45,884 invasive breast cancer patients (aged 18-64 years), treated from 2003 to 2010 with lumpectomy, followed by brachytherapy (n=3134) or whole-breast irradiation (n=42,750). We stratified patients into risk groups according to age (Age<50 vs Age≥50) and endocrine therapy status (Endocrine− vs Endocrine+). “Endocrine+” patients filled an endocrine therapy prescription within 1 year after lumpectomy. Pathologic hormone receptor status was not available in this dataset. In brachytherapy versus WBI patients, utilization trends and 5-year subsequent mastectomy risks were compared. Stratified, adjusted subsequent mastectomy risks were calculated using proportional hazards regression. Results: Brachytherapy utilization increased from 2003 to 2010: in patients Age<50, from 0.6% to 4.9%; patients Age≥50 from 2.2% to 11.3%; Endocrine− patients, 1.3% to 9.4%; Endocrine+ patients, 1.9% to 9.7%. Age influenced treatment selection more than endocrine status: 17% of brachytherapy patients were Age<50 versus 32% of WBI patients (P<.001); whereas 41% of brachytherapy patients were Endocrine–versus 44% of WBI patients (P=.003). Highest absolute 5-year subsequent mastectomy risks occurred in Endocrine−/Age<50 patients (24.4% after brachytherapy vs 9.0% after WBI (hazard ratio [HR] 2.18, 95% confidence interval [CI] 1.37-3.47); intermediate risks in Endocrine−/Age≥50 patients (8.6% vs 4.9%; HR 1.76, 95% CI 1.26-2.46); and lowest risks in Endocrine+ patients of any age: Endocrine+/Age<50 (5.5% vs 4.5%; HR 1.18, 95% CI 0.61-2.31); Endocrine+/Age≥50 (4.2% vs 2

  16. Nuclear Reactor Component Code CUPID-I: Numerical Scheme and Preliminary Assessment Results

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Hyoung Kyu; Jeong, Jae Jun; Park, Ik Kyu; Kim, Jong Tae; Yoon, Han Young

    2007-12-15

    A component scale thermal hydraulic analysis code, CUPID (Component Unstructured Program for Interfacial Dynamics), is being developed for the analysis of components of a nuclear reactor, such as reactor vessel, steam generator, containment, etc. It adopted three-dimensional, transient, two phase and three-field model. In order to develop the numerical schemes for the three-field model, various numerical schemes have been examined including the SMAC, semi-implicit ICE, SIMPLE, Row Scheme and so on. Among them, the ICE scheme for the three-field model was presented in the present report. The CUPID code is utilizing unstructured mesh for the simulation of complicated geometries of the nuclear reactor components. The conventional ICE scheme that was applied to RELAP5 and COBRA-TF, therefore, were modified for the application to the unstructured mesh. Preliminary calculations for the unstructured semi-implicit ICE scheme have been conducted for a verification of the numerical method from a qualitative point of view. The preliminary calculation results showed that the present numerical scheme is robust and efficient for the prediction of phase changes and flow transitions due to a boiling and a flashing. These calculation results also showed the strong coupling between the pressure and void fraction changes. Thus, it is believed that the semi-implicit ICE scheme can be utilized for transient two-phase flows in a component of a nuclear reactor.

  17. Qualitative Measurement of Landscape Structure in an Urbanizing Region: A New Method and Preliminary Results

    Science.gov (United States)

    Bunn, J. T.

    2006-12-01

    Landscape pattern analysis typically involves the mathematical derivation of quantitative metrics from classified rasterized aerial images and/or maps. Recent work by architect Christopher Alexander, however, suggests a new holistic approach to the measurement of landscape structure, based on properties of the relationships between coherent wholes. Measurement of these properties and relationships relies upon qualitative judgment and aesthetic perception, but can be quantified using ordinal scaling and tests of intersubject agreement. I demonstrate how these qualitative pattern measures can be assessed through the use of aerial orthophotographs, and describe preliminary results relating them to an indicator of biodiversity in the urbanizing Pacific Northwest (USA) landscape. I conducted a double-blind survey in which subjects used Alexander's properties to compare aerial photographs of 1 km2 landscapes along an urban to rural gradient in the vicinity of Seattle, Washington. The photographs were of locations with measured avian biodiversity, and represent a range of land-cover types and development patterns. Subjects compared 23 pairs of images, using aesthetic judgement to choose the one in each pair that they felt expresses Alexander's properties to a greater degree. Preliminary results indicate that intersubjective agreement is significantly better than chance for most image pairs (p <= 0.05), and that for most subjects the photographs judged higher in Alexander's properties correspond to the locations with higher bird species richness, at a frequency significantly greater than would be expected by chance (p <= 0.05).

  18. Preliminary results of combined ESR/U-series dating of fossil teeth from Longgupo cave, China

    International Nuclear Information System (INIS)

    Longgupo Cave site, located in Wushan County, Chongqing, China has attracted continuous attention since its discovery of hominid remains in association with late Pliocene-early Pleistocene fauna and numerous lithic artefacts. In 2003-2006, new excavation was carried out on this site, allowing the description of a detailed stratigraphy of the highly complex cave in-fillings and the sampling of teeth for combined ESR/U-series analyses. Here we report preliminary dating results of seven herbivorous fossil teeth from different archaeological layers of the lowest geological unit (C III). Uranium-series analyses indicate that no obvious uranium leaching has occurred and all the teeth (except one) underwent a very recent uranium uptake history. The obtained US-ESR results show that the age of six teeth are basically consistent, between similar to 1.4 and 1.8 Ma. At the same time, we observed an inverse correlation of two samples with the stratigraphic sequence. This could be caused by the distinct uranium uptake history of one sample, high uranium content in the enamel for another or bad estimation of external dose rate. Due to the complexity of the stratigraphic sequence, supplementary in situ gamma dose rate measurement should be performed for all the samples during the following excavations in order to confirm this preliminary ESR/U-series chronology. (authors)

  19. Erectile function after permanent prostate brachytherapy

    International Nuclear Information System (INIS)

    Purpose: To determine the incidence of potency preservation after permanent prostate brachytherapy using a validated patient-administered questionnaire and to evaluate the effect of multiple clinical and treatment parameters on penile erectile function. Methods and Materials: Four hundred twenty-five patients underwent permanent prostate brachytherapy from April 1995 to October 1999. Two hundred nine patients who were potent before brachytherapy and who at the time of the survey were not receiving hormonal therapy were mailed the specific erectile questions of the International Index of Erectile Function (IIEF) questionnaire with a self-addressed stamped envelope. The questionnaire consisted of 5 questions, with a maximal score of 25. Of the 209 patients, 181 (87%) completed and returned the questionnaire. The mean and median follow-up was 40.4±14.9 and 40.6 months, respectively (range 19-75). Preimplant erectile function was assigned using a three-tiered scoring system (2 = erections always or nearly always sufficient for vaginal penetration; 1 = erections sufficient for vaginal penetration but considered suboptimal; 0 = the inability to obtain erections and/or erections inadequate for vaginal penetration). Postimplant potency was defined as an IIEF score ≥11. The clinical parameters evaluated for erectile function included patient age, preimplant potency, clinical T-stage, pretreatment prostate-specific antigen level, Gleason score, elapsed time after implantation, hypertension, diabetes mellitus, and tobacco consumption. Treatment parameters included radiation dose to the prostate gland, use of hormonal manipulation, use of supplemental external beam radiotherapy (EBRT), choice of isotope, prostate volume, and planning volume. The efficacy of sildenafil citrate in brachytherapy-induced erectile dysfunction (ED) was also evaluated. Results: Pretreatment erectile function scores of 2 and 1 were assigned to 125 and 56 patients, respectively. With a 6-year follow

  20. Preliminary results from the investigation of thermal effects in electrokinetics soil remediation

    International Nuclear Information System (INIS)

    Electrokinetics is an emerging soil remediation technology. Contaminants are extracted from the soil as a result of a complex set of phenomena that occur when an electric gradient is imposed across a soil-water system. The primary phenomena include electroosmosis, electromigration, and electrophoresis. Secondary phenomena, such as changes in solubility or speciation of various chemical components, may occur as a result of electrically induced changes in the chemical environment of the system. Numerous factors, such as temperature, may affect each of these phenomena and, consequently, the overall process efficiency. We have begun an investigation of thermal effects in the extraction of potassium dichromate from kaolinite soils under conditions of constant saturation and dewatering. Preliminary results suggest that increasing the soil temperature from 21 to 55 degrees C may decrease the processing time under saturated conditions. However, increasing the soil temperature under dewatering, conditions causes soil cracking, which reduces the overall process efficiency

  1. Accelerated partial breast irradiation with multi-catheter brachytherapy: Local control, side effects and cosmetic outcome for 274 patients. Results of the German-Austrian multi-centre trial

    International Nuclear Information System (INIS)

    Background and purpose: To evaluate the safety and effectiveness of accelerated partial breast irradiation (APBI) with multi-catheter brachytherapy. Patients and methods: Between 11/2000 and 04/2005, 274 patients participated. Patients were eligible for APBI if they had histologically confirmed breast cancer, a tumour diameter ≤3 cm, complete resection with clear margins ≥2 mm, negative axillary lymph nodes or singular nodal micro-metastasis, no distant metastases, hormone receptor-positive tumours, and were ≥35 years. Patients were excluded if mammographically they showed a multicentric invasive growth pattern, poorly differentiated tumours, residual diffuse micro-calcifications, extensive intraductal component, or vessel invasion. Median follow-up was 32 months (range; 8-68). Results: The local control rate was 99.3% (272/274), the 3 year-local-recurrence-free survival probability, 99.6%. Peri-operative complications occurred in 5.5% (15/274): 9 (3.3%) experienced implant infection and 6 (2.2%) hematoma. Acute toxicity (Grade 1/2 radio-dermatitis) was seen in 6.6% (18/274). Late side effects ≥ Grade 3 (fibrosis, telangiectasia) occurred in 1.8% (4/274). Cosmetic results were excellent/good in 94% (253/274). Conclusions: This analysis underlined the safety and effectiveness of APBI in a carefully selected subgroup with favourable disease characteristics. Of course, longer follow-up and randomised trials are necessary to conclusively assess the potential of APBI

  2. Ocular Response of Choroidal Melanoma With Monosomy 3 Versus Disomy 3 After Iodine-125 Brachytherapy

    International Nuclear Information System (INIS)

    Purpose: To report the ocular response of choroidal melanoma with monosomy 3 vs. disomy 3 after 125I brachytherapy. Methods and Materials: We evaluated patients with ciliochoroidal melanoma managed with fine needle aspiration biopsy immediately before plaque application for 125I brachytherapy between January 1, 2005 and December 31, 2008. Patients with (1) cytopathologic diagnosis of melanoma, (2) melanoma chromosome 3 status identified by fluorescence in situ hybridization, and (3) 6 or more months of follow-up after brachytherapy were sorted by monosomy 3 vs. disomy 3 and compared by Kruskal-Wallis test. Results: Among 40 ciliochoroidal melanomas (40 patients), 15 had monosomy 3 and 25 had disomy 3. Monosomy 3 melanomas had a median greatest basal diameter of 12.00 mm and a median tumor thickness of 6.69 mm before brachytherapy; at a median of 1.75 years after brachytherapy, median thickness was 3.10 mm. Median percentage decrease in tumor thickness was 48.3%. Disomy 3 melanomas had a median greatest basal diameter of 10.00 mm and median tumor thickness of 3.19 mm before brachytherapy; at a median of 2.00 years after brachytherapy, median tumor thickness was 2.37 mm. The median percentage decrease in tumor thickness was 22.7%. Monosomy 3 melanomas were statistically greater in size than disomy 3 melanomas (p < 0.001) and showed a greater decrease in tumor thickness after brachytherapy (p = 0.006). Conclusion: In this study, ciliochoroidal melanomas with monosomy 3 were significantly greater in size than disomy 3 melanoma and showed a significantly greater decrease in thickness at a median of 1.75 years after brachytherapy. The greater decrease in monosomy 3 melanoma thickness after brachytherapy is consistent with other malignancies in which more aggressive pathology has been shown to be associated with a greater initial response to radiotherapy.

  3. A color spectrographic phonocardiography (CSP applied to the detection and characterization of heart murmurs: preliminary results

    Directory of Open Access Journals (Sweden)

    Hassani Kamran

    2011-05-01

    Full Text Available Abstract Background Although cardiac auscultation remains important to detect abnormal sounds and murmurs indicative of cardiac pathology, the application of electronic methods remains seldom used in everyday clinical practice. In this report we provide preliminary data showing how the phonocardiogram can be analyzed using color spectrographic techniques and discuss how such information may be of future value for noninvasive cardiac monitoring. Methods We digitally recorded the phonocardiogram using a high-speed USB interface and the program Gold Wave http://www.goldwave.com in 55 infants and adults with cardiac structural disease as well as from normal individuals and individuals with innocent murmurs. Color spectrographic analysis of the signal was performed using Spectrogram (Version 16 as a well as custom MATLAB code. Results Our preliminary data is presented as a series of seven cases. Conclusions We expect the application of spectrographic techniques to phonocardiography to grow substantially as ongoing research demonstrates its utility in various clinical settings. Our evaluation of a simple, low-cost phonocardiographic recording and analysis system to assist in determining the characteristic features of heart murmurs shows promise in helping distinguish innocent systolic murmurs from pathological murmurs in children and is expected to useful in other clinical settings as well.

  4. Radioinduced modifications of the skin relief: preliminary results in the pig

    International Nuclear Information System (INIS)

    The evolution of the cutaneous relief depends on physiological and physical parameters such as sex, aging, hydratation and radiations. Composed of plateaus crossed by valleys, the skin surface topography can be studied by a 3D topographic and a 2D profilometric analysis of the distribution of the relief parameters. This preliminary study of the irradiated skin topography showed a relative decrease of the vertical amplitude parameters (-15%) of the skin relief in three pigs irradiated with single doses of 90Sr-90Y β rays (32,64 and 96 Gy under 7 mg/cm2; skin source distance: 2.6 cm) and one pig irradiated with a single dose of 192Ir γ rays (160 Gy skin surface dose; skin source distance: 1.7 cm), 24 h after irradiation whatever the dose. This preliminary result will be developed in a larger study group of pigs and a longer time period, to define the threshold dose of irradiation that induces modifications of the skin topography, before being validated in humans. (authors). 26 refs., 3 figs., 2 tabs

  5. Preliminary assessment of the Long Island National Wildlife Refuge Complex Environmental contaminants background survey: Second year results

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report represents the preliminary results of the second year of the multiyear study, The Long Island National Wildlife Refuge Complex (Complex) Environmental...

  6. Properties of ABNT 41xx and 86xx cast steel modified with niobium; evaluation methodology and experimental preliminary results

    International Nuclear Information System (INIS)

    The experimental methodology to evaluate the mechanical properties of ABNT 41xx and 86xx steels modified with NB in the as cast and heat treated conditions and the first preliminary results obtained in a laboratory scale, are presented. (Author)

  7. Preliminary assessment of the Long Island National Wildlife Refuge Complex environmental contaminants background study: Fifth year results

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report represents the preliminary results of the fifth year of the multiyear study entitled, "The Long Island National Wildlife Refuge Complex (Complex)...

  8. Dosimetric characterization and output verification for conical brachytherapy surface applicators. Part I. Electronic brachytherapy source

    International Nuclear Information System (INIS)

    Purpose: Historically, treatment of malignant surface lesions has been achieved with linear accelerator based electron beams or superficial x-ray beams. Recent developments in the field of brachytherapy now allow for the treatment of surface lesions with specialized conical applicators placed directly on the lesion. Applicators are available for use with high dose rate (HDR)192Ir sources, as well as electronic brachytherapy sources. Part I of this paper will discuss the applicators used with electronic brachytherapy sources; Part II will discuss those used with HDR 192Ir sources. Although the use of these applicators has gained in popularity, the dosimetric characteristics including depth dose and surface dose distributions have not been independently verified. Additionally, there is no recognized method of output verification for quality assurance procedures with applicators like these. Existing dosimetry protocols available from the AAPM bookend the cross-over characteristics of a traditional brachytherapy source (as described by Task Group 43) being implemented as a low-energy superficial x-ray beam (as described by Task Group 61) as observed with the surface applicators of interest. Methods: This work aims to create a cohesive method of output verification that can be used to determine the dose at the treatment surface as part of a quality assurance/commissioning process for surface applicators used with HDR electronic brachytherapy sources (Part I) and192Ir sources (Part II). Air-kerma rate measurements for the electronic brachytherapy sources were completed with an Attix Free-Air Chamber, as well as several models of small-volume ionization chambers to obtain an air-kerma rate at the treatment surface for each applicator. Correction factors were calculated using MCNP5 and EGSnrc Monte Carlo codes in order to determine an applicator-specific absorbed dose to water at the treatment surface from the measured air-kerma rate. Additionally, relative dose

  9. HDR neutron brachytherapy for prostatic cancer in lithuania

    International Nuclear Information System (INIS)

    The purpose of this report is to analyse the physical and radiobiological background of the HDR Cf-252 Neutron brachytherapy boost in the combined radiation therapy for locally advanced prostatic cancer. The treatment schedule:two fractions of the Cf-252 brachytherapy(5Gy-eq at the dose point 2 cm from source movement trajectory) with interval 24 hours; 5-8 fractions of the photon beam external radiation therapy(5 fractions per week, 2 Gy per fraction) to the prostate, two fractions of the Cf-252 brachytherapy and after that external beam radiation therapy is continued till total dose 40-45 Gy. Six patients completed the proposed combined radiation therapy. The results of this trial will be discussed

  10. Prostate brachytherapy in patients with prior evidence of prostatitis

    International Nuclear Information System (INIS)

    Purpose: To refute a misconception that a prior history of prostatitis is a contraindication to prostate brachytherapy. Methods and Materials: Five patients with clinical or pathologic evidence of prior prostatitis were treated with transperineal brachytherapy. Four of the patients received a single i.v. dose of ciprofloxacin (500 mg) intraoperatively. Postimplant antibiotics were not given. The pretreatment biopsy slides were reviewed. Results: Two of the five patients developed postimplant urinary retention requiring short-term catheterization, and both resolved spontaneously. One patient developed what appeared to be an exacerbation of his chronic prostatitis. Conclusion: We continue to recommend prostate brachytherapy for the treatment of clinically organ-confined cancer, with no concern about prior clinical or pathologic evidence of prostatitis

  11. Hybrid Spectral Micro-CT: System Design, Implementation, and Preliminary Results

    CERN Document Server

    Bennett, James R; Xu, Qiong; Yu, Hengyong; Walsh, Michael; Butler, Anthony; Butler, Phillip; Cao, Guohua; Mohs, Aaron; Wang, Ge

    2014-01-01

    Spectral CT has proven an important development in biomedical imaging, and there have been several publications in the past years demonstrating its merits in pre-clinical and clinical applications. In 2012, Xu et al. reported that near-term implementation of spectral micro-CT could be enhanced by a hybrid architecture: a narrow-beam spectral "interior" imaging chain integrated with a traditional wide-beam "global" imaging chain. This hybrid integration coupled with compressive sensing (CS)-based interior tomography demonstrated promising results for improved contrast resolution, and decreased system cost and radiation dose. The motivation for the current study is implementation and evaluation of the hybrid architecture with a first-of-its-kind hybrid spectral micro-CT system. Preliminary results confirm improvements in both contrast and spatial resolution. This technology is shown to merit further investigation and potential application in future spectral CT scanner design.

  12. Modelling lung cancer due to radon and smoking in WISMUT miners: Preliminary results

    International Nuclear Information System (INIS)

    A mechanistic two-stage carcinogenesis model has been applied to model lung-cancer mortality in the largest uranium-miner cohort available. Models with and without smoking action both fit the data well. As smoking information is largely missing from the cohort data, a method has been devised to project this information from a case-control study onto the cohort. Model calculations using 256 projections show that the method works well. Preliminary results show that if an explicit smoking action is absent in the model, this is compensated by the values of the baseline parameters. This indicates that in earlier studies performed without smoking information, the results obtained for the radiation parameters are still valid. More importantly, the inclusion of smoking-related parameters shows that these mainly influence the later stages of lung-cancer development. (authors)

  13. MAX-DOAS measurements of tropospheric NO2 over San Salvador: preliminary results

    Science.gov (United States)

    Alberti, Carlos; Wagner, Thomas

    2015-04-01

    We present the first Multi-AXis-Differential Optical Absorption Spectroscopy (MAX-DOAS) measurements at San Salvador. MAX-DOAS observes spectra of scattered sun light taken at different elevation angles. From the spectra the so called slant column density (SCD, the integrated trace gas concentration along the atmospheric light path) is derived. We quantify the dSCD of NO2 at different measurement conditions. From the measured NO2 SCDs we calculate the tropospheric vertical column density using the so called geometric approximation. The preliminary results of this MAX DOAS observations and the diurnal variation of the retrieved trace gas dSCDs will be presented. We also use the MAX-DOAS results for the validation of satellite observations.

  14. Comparison of stroke infarction between CT perfusion and diffusion weighted imaging: preliminary results

    Science.gov (United States)

    Abd. Rahni, Ashrani Aizzuddin; Arka, Israna Hossain; Chellappan, Kalaivani; Mukari, Shahizon Azura; Law, Zhe Kang; Sahathevan, Ramesh

    2016-03-01

    In this paper we present preliminary results of comparison of automatic segmentations of the infarct core, between that obtained from CT perfusion (based on time to peak parameter) and diffusion weighted imaging (DWI). For each patient, the two imaging volumes were automatically co-registered to a common frame of reference based on an acquired CT angiography image. The accuracy of image registration is measured by the overlap of the segmented brain from both images (CT perfusion and DWI), measured within their common field of view. Due to the limitations of the study, DWI was acquired as a follow up scan up to a week after initial CT based imaging. However, we found significant overlap of the segmented brain (Jaccard indices of approximately 0.8) and the percentage of infarcted brain tissue from the two modalities were still fairly highly correlated (correlation coefficient of approximately 0.9). The results are promising with more data needed in future for clinical inference.

  15. RR Lyrae search and stellar populations study in Canis Major: Preliminary Results

    CERN Document Server

    Mateu, C E; Zinn, R; Miller, L; Mateu, Cecilia E.; Zinn, Robert; Miller, Lissa

    2005-01-01

    We present preliminary results of a RR Lyrae star search and stellar populations study performed in the Canis Major overdensity, spanning an area of 8.35sq deg. The observations were made in R and V bands, with the QUEST camera installed in the 1m Jurgen Stock Telescope, at the Venezuela National Observatory. The resulting Hess diagram shows a possible, but weak, red giant branch and no obvious horizontal branch, red clump or main sequence turnoff. After a multi--epoch photometric search, 6 RR Lyrae stars were confirmed with further observations obtained at the 1.0 and 1.3m telescopes of the SMARTS consortium at CTIO. Of these confirmed RR Lyrae stars, 5 have heliocentric distances between 5 and 7 kpc. Confirmation of their physsical association with the Canis Major system awaits for a study of their radial velocities.

  16. PDM performance Test Results and Preliminary Analysis: Incompressible and Compressible Fluids

    Energy Technology Data Exchange (ETDEWEB)

    Dreesen, D.S.; Gruenhagan, E.; Cohen, J.C.; Moran, D.W.

    1999-02-01

    Three, small diameter, Moineau, positive displacement (drilling) motors (PDMs) were dynamometer tested using water, air-water mist, air-water foam, and aerated water. The motors included (1) a 1.5-inch OD, single-lobe mud motor; (2) a 1.69-inch OD, 5:6 multi-lobe mud motor; and (3) a 1.75-inch OD, 5:6 multi-lobe air motor. This paper describes the test apparatus, procedures, data analysis, and results. Incompressible and compressible fluid performance are compared; linear performance, predicted by a positive displacement motor model, is identified where it occurs. Preliminary results and conclusions are (1) the performance of all three motors is accurately modeled using a two-variable, linear model for incompressible fluid and (2) the model was not successfully adapted to model compressible fluid performance.

  17. MAX-DOAS observations of trace gases over Mainz: preliminary results

    Science.gov (United States)

    Alberti, Carlos; Gu, Myojeong; Remmers, Julia; Wagner, Thomas

    2014-05-01

    In this work we report on levels of trace gases in ambient atmosphere in Mainz, Germany. We measured the differential Slant Column Density (dSCD) of NO2, HCHO and O4 in the ultraviolet region of the electromagnetic spectrum using a Mini-MAX-DOAS instrument. The MAX-DOAS observations were taken at Max Planck Institute for Chemistry in Mainz, from January to March 2014, at different elevation angles. The main aim of the study is to compare the results of the Mini-MAX-DOAS instrument with those from a 'scientific' MAX-DOAS instrument operated simultaneously at the same location. We quantify systematic differences and random and errors of both data sets for different measurement conditions. The preliminary results of this MAX DOAS observations and the diurnal variation of the retrieved trace gas DSCDs will be discussed in this work.

  18. Preliminary results of measurement of natural environmental radiation levels and doses to population in China

    International Nuclear Information System (INIS)

    In this paper the preliminary results of measurement of natural environmental radiation levels in China with RSS-111 high pressure ionization chamber and estimated doses to population are reported. A total of 2,723 indoor locales throughout China were measured. The results showed that the average absorbed dose rates in air due to gamma radiation for indoors and outdoors were 11.0 x 10-8 Gy.h-1 and 7.4 x 10-8 Gy.h-1, respectively, and those due to cosmic rays were 3.2 x 10-8 Gy.h-1 and 3.7 x 10-8 Gy.h-1, respectively. The annual average effective dose equivalent to population was 919 μSv, including 630 μSv from natural gamma radiation and 289 μSv from cosmic rays

  19. Measurement of pressure ridges in SAR images of sea ice - Preliminary results on scattering theory

    Science.gov (United States)

    Vesecky, J. F.; Smith, M. P.; Daida, J. M.; Samadani, R.; Camiso, J. C.

    1992-01-01

    Sea ice ridges and keels (hummocks and bummocks) are important in sea ice research for both scientific and practical reasons. A long-term objective is to make quantitative measurements of sea ice ridges using synthetic aperture radar (SAR) images. The preliminary results of a scattering model for sea ice ridge are reported. The approach is through the ridge height variance spectrum Psi(K), where K is the spatial wavenumber, and the two-scale scattering model. The height spectrum model is constructed to mimic height statistics observed with an airborne optical laser. The spectrum model is used to drive a two-scale scattering model. Model results for ridges observed at C- and X-band yield normalized radar cross sections that are 10 to 15 dB larger than the observed cross sections of multiyear ice over the range of angles of incidence from 10 to 70 deg.

  20. Development of methods to measure hemoglobin adducts by gel electrophoresis - Preliminary results

    International Nuclear Information System (INIS)

    Chemical adducts formed on blood hemoglobin may be a useful biomarker for assessing human exposures to these compounds. This paper reports preliminary results in the development of methods to measure such adducts that may be generally applicable for a wide variety of chemicals. Male F344/N rats were intraperitoneally injected with 14C-BaP dissolved in corn oil. Twenty-four hours later, the rats were sacrificed. Blood samples were collected and globin was isolated. Globin protein was then cleaved into peptide fragments using cyanogen bromide and the fragments separated using 2-dimensional gel electrophoresis. The results showed that the adducted 14C-globin fragments migrated to different areas of the gel than did unadducted fragments. Further research is being conducted to develop methods that will allow quantitation of separated adducted globin fragments from human blood samples without the use of a radiolabel. (author)

  1. Modelled and Observed Diurnal SST Signals: "SSTDV:R.EX.-IM.A.M." Project Preliminary Results

    DEFF Research Database (Denmark)

    Karagali, Ioanna; Høyer, Jacob; LeBorgne, Pierre;

    2013-01-01

    This study presents some of the preliminary results from the ESA Support To Science Element (STSE) funded project on the Diurnal Variability of the Sea Surface Temperature, regarding its Regional Extend and Implications in Atmospheric Modelling (SSTDV:R.EX.–IM.A.M.). During this phase of the...... project, the focus is on the regional extend of diurnal variability. Particularly, extensive sensitivity tests regarding the definition of SSTfound fields show that using only quality 5 SEVIRI data results in warmer foundation fields SSTfound while there is an added ∼0.2 K variability when using multi......-day composites. Diurnal warming signals exceeding 1 K are identified in the European Seas but also in the mid-latitudes of the North and South Atlantic as well as in areas with strong currents. In the attempt to connect temperature measurements from satellites and in situ instruments, the 1-dimensional General...

  2. Sugars as double-signal high dose dosimeters of ionizing radiation. Preliminary results

    International Nuclear Information System (INIS)

    Preliminary results of investigation of some sugars (maltose, saccharose, commercial sugar) as sensor materials for a high dose dosimetry of ionizing radiation are presented. An advantage of using sugars consists in fact that ionizing radiation creates in them two kind of signals: colour centers (spectrophotometric read-out) and paramagnetic centers (read-out by EPR method). This allows to chose more convenient - in particular conditions a method of analysis and more exactly to estimate uncertainties connected with analytical procedures. The results indicate saccharose as better than others dosimetric material with a threshold at ∼ 100 Gy for the EPR method and ∼ 5 Gy for the optical one. The investigation reveals a high discrepancy of physicochemical parameters and generally a low quality of Polish grocery sugar. (author)

  3. Life span studies on mice exposed to heavy charged particles or photons: preliminary results

    International Nuclear Information System (INIS)

    This chapter summarizes the results currently available where dose-dependent mortality is compared among the single cohort that received fractionated doses of carbon ions and the first replicate that received single doses. At this time, 17% mortality has occurred in both groups and had enhanced life shortening been produced by fractionation of the carbon ion dose, somewhat higher mortality might be expected. Cautious interpretation of these preliminary results is necessary, but the mortality data available at this time provides no evidence for enhancement by dose fractionation with carbon ions. In sum, at this time, it appears the Q factor used for fission spectrum neutrons could be conservative if it were used for assessment of risk following exposure to 400 MeV carbon ions

  4. Use of the scanner and 3D dosimetry in the evaluation of dose distribution of prostate carcinomas treatment by association of an interstitial brachytherapy with iridium 192 and an external radiotherapy

    International Nuclear Information System (INIS)

    The implementation of this technique leads to a conformational approach of the prostate cancer treatment, by association of brachytherapy and external radiotherapy. The next advance will consist in replacing the classical marking by orthogonal images by a complete visual simulation for the preliminary dosimetry of brachytherapy and external radiotherapy. (N.C.)

  5. Palliative brachytherapy with or without primary stent placement in patients with oesophageal cancer, a randomised phase III trial

    International Nuclear Information System (INIS)

    Purpose: To investigate whether a combination of self-expanding metal stent (SEMS) and brachytherapy provided more rapid and prolonged effect on dysphagia without increased pain compared to brachytherapy alone in patients with incurable oesophageal cancer. Methods: 41 Patients were randomised to SEMS followed by brachytherapy, 8 Gy × 3 (n = 21) or brachytherapy alone, 8 Gy × 3 (n = 20). Change in dysphagia and pain three and seven weeks after randomisation (FU1 and FU2) was assessed by patient-reported outcome. Dysphagia, other symptoms and health-related quality of life were assessed every four weeks thereafter. The study was closed before the estimated patient-number was reached due to slow recruitment. Results: Patients receiving SEMS followed by brachytherapy had significantly improved dysphagia at FU1 compared to patients receiving brachytherapy alone (n = 35). Difference in pain was not observed. At FU2, patients in both arms (n = 21) had less dysphagia. Four patients in the combined treatment arm experienced manageable complications, no complications occurred after brachytherapy alone. Conclusion: For the relief of dysphagia, SEMS followed by brachytherapy is preferable and safe for patients in need of immediate alleviation, while brachytherapy with or without preceding SEMS provides relief within a few weeks after treatment

  6. Validation of GPUMCD for low-energy brachytherapy seed dosimetry

    Energy Technology Data Exchange (ETDEWEB)

    Hissoiny, Sami; Ozell, Benoit; Despres, Philippe; Carrier, Jean-Francois [Ecole polytechnique de Montreal, Departement de genie informatique et genie logiciel, 2500 chemin de Polytechnique, Montreal, QC, H3T 1J4 (Canada); Departement de radio-oncologie, Centre hospitalier universitaire de Quebec (CHUQ), 11 Cote du Palais, Quebec, QC, G1R 2J6 (Canada); Departement de physique, Universite de Montreal, Montreal, QC (Canada) and Departement de radio-oncologie and Centre de recherche du CHUM, Centre hospitalier de l' Universite de Montreal (CHUM), Montreal, QC, H2L 4M1 (Canada)

    2011-07-15

    Purpose: To validate GPUMCD, a new package for fast Monte Carlo dose calculations based on the GPU (graphics processing unit), as a tool for low-energy single seed brachytherapy dosimetry for specific seed models. As the currently accepted method of dose calculation in low-energy brachytherapy computations relies on severe approximations, a Monte Carlo based approach would result in more accurate dose calculations, taking in to consideration the patient anatomy as well as interseed attenuation. The first step is to evaluate the capability of GPUMCD to reproduce low-energy, single source, brachytherapy calculations which could ultimately result in fast and accurate, Monte Carlo based, brachytherapy dose calculations for routine planning. Methods: A mixed geometry engine was integrated to GPUMCD capable of handling parametric as well as voxelized geometries. In order to evaluate GPUMCD for brachytherapy calculations, several dosimetry parameters were computed and compared to values found in the literature. These parameters, defined by the AAPM Task-Group No. 43, are the radial dose function, the 2D anisotropy function, and the dose rate constant. These three parameters were computed for two different brachytherapy sources: the Amersham OncoSeed 6711 and the Imagyn IsoStar IS-12501. Results: GPUMCD was shown to yield dosimetric parameters similar to those found in the literature. It reproduces radial dose functions to within 1.25% for both sources in the 0.5< r <10 cm range. The 2D anisotropy function was found to be within 3% at r = 5 cm and within 4% at r = 1 cm. The dose rate constants obtained were within the range of other values reported in the literature.Conclusion: GPUMCD was shown to be able to reproduce various TG-43 parameters for two different low-energy brachytherapy sources found in the literature. The next step is to test GPUMCD as a fast clinical Monte Carlo brachytherapy dose calculations with multiple seeds and patient geometry, potentially providing

  7. Towards seasonal hydrological forecasting in mountain catchments: preliminary results from the APRIL project

    Science.gov (United States)

    Pistocchi, Alberto; Mazzoli, Paolo; Bagli, Stefano; Notarnicola, Claudia; Pasolli, Luca

    2013-04-01

    The APRIL project aims at addressing the long term quantitative prediction of monthly discharge from mountain catchments and setting up a system which can then be used operationally. More specifically, its objectives are: - To investigate the potential of EO products (snow cover extent, vegetation and soil moisture statust) and weather/climatic variables for the prediction of water streamflow from mountain catchments - To develop a robust methodology for the long term quantitative forecast of montly discharge from EO and weather/climatic data - To build a fully operational system for seasonal hydrological forecasting. This contribution illustrates the general concept of the project as well as some preliminary results. Water discharge in mountain catchments is physically related to antecedent snow cover and climatology (precipitation, temperature). Other factors may play a role, such as vegetation/soil status and topography. Historical discharge measurements and earth observation (EO) data are a valuable source for inferring the quantitative relationship between the discharge and its predictors using appropriate techniques. The prediction is based on the Support Vector Regression (SVR)technique, a state of the art machine learning regression method with good intrinsic generalization ability and robustness. In the contribution we present and discuss results of a preliminary analysis on water discharge prediction ( with lead time of 1 to 3 months) in South Tyrol, Italy. Despite the use of a limited set of predictors (among which mainly snow cover area), the results are encouraging. The analysis is in the process of being extended at different spatial scales, which will give the possibility to investigate different aspects of the problem and develop different prediction systems; by updating on the current developments, the contribution discusses also perspectives and current limitations towards the set up of a fully operational seasonal hydrological forecasting system

  8. Local anesthesia for prostate brachytherapy

    International Nuclear Information System (INIS)

    Purpose: To demonstrate the technique and feasibility of prostate brachytherapy performed with local anesthesia only. Methods and Materials: A 5 by 5 cm patch of perineal skin and subcutaneous tissue is anesthetized by local infiltration of 10 cc of 1% lidocaine with epinephrine, using a 25-gauge 5/8-inch needle. Immediately following injection into the subcutaneous tissues, the deeper tissues, including the pelvic floor and prostate apex, are anesthetized by injecting 15 cc lidocaine solution with approximately 8 passes of a 20-gauge 1.0-inch needle. Following subcutaneous and peri-apical lidocaine injections, the patient is brought to the simulator suite and placed in leg stirrups. The transrectal ultrasound (TRUS) probe is positioned to reproduce the planning images and a 3.5- or 6.0-inch, 22-gauge spinal needle is inserted into the peripheral planned needle tracks, monitored by TRUS. When the tips of the needles reach the prostatic base, about 1 cc of lidocaine solution is injected in the intraprostatic track, as the needle is slowly withdrawn, for a total volume of 15 cc. The implants are done with a Mick Applicator, inserting and loading groups of two to four needles, so that a maximum of only about four needles are in the patient at any one time. During the implant procedure, an additional 1 cc of lidocaine solution is injected into one or more needle tracks if the patient experiences substantial discomfort. The total dose of lidocaine is generally limited to 500 mg (50 ml of 1% solution). Results: To date, we have implanted approximately 50 patients in our simulator suite, using local anesthesia. Patients' heart rate and diastolic blood pressure usually showed moderate changes, consistent with some discomfort. The time from first subcutaneous injection and completion of the source insertion ranged from 35 to 90 minutes. Serum lidocaine levels were below or at the low range of therapeutic. There has been only one instance of acute urinary retention in the

  9. Perioperative interstitial brachytherapy for recurrent keloid scars

    International Nuclear Information System (INIS)

    Purpose: Evaluation of the results of perioperative interstitial brachytherapy with low dose-rate (L.D.R.) Ir-192 in the treatment of keloid scars. Patients and methods: We performed a retrospective analysis of 73 histologically confirmed keloids (from 58 patients) resistant to medico surgical treated by surgical excision plus early perioperative brachytherapy. All lesions were initially symptomatic. Local control was evaluated by clinical evaluation. Functional and cosmetic results were assessed in terms of patient responses to a self-administered questionnaire. Results: Median age was 28 years (range 13-71 years). Scars were located as follows: 37% on the face, 32% on the trunk or abdomen, 16% on the neck, and 15% on the arms or legs. The mean delay before loading was four hours (range, 1-6 h). The median dose was 20 Gy (range, 15-40 Gy). Sixty-four scars (from 53 patients) were evaluated. Local control was 86% (follow-up, 44.5 months; range, 14-150 months). All relapses occurred early within 2 years posttreatment. At 20 months, survival without recurrence was significantly lower when treated lengths were more than 6 cm long. The rate was 100% for treated scars below 4.5 cm in length, 95% (95% CI: 55-96) for those 4.5-6 cm long, and 75% (95% CI: 56-88) beyond 6 cm (p = 0.038). Of the 35 scars (28 patients) whose results were reassessed, six remained symptomatic and the esthetic results were considered to be good in 51% (18/35) and average in 37% (13/35) (median follow-up, 70 months; range, 16-181 months). Conclusion: Early perioperative L.D.R. brachytherapy delivering 20 Gy at 5 mm reduced the rate of recurrent keloids resistant to other treatments and gave good functional results. (authors)

  10. New brachytherapy standards paradigm shift

    International Nuclear Information System (INIS)

    Full text: The absorbed dose rate to water at short distances (1 cm typically) in water, is the quantity of interest for dosimetry in radiotherapy treatments. Moreover, the dose imparted to cancer patients must be known within a narrow band of uncertainty to avoid either damage to the healthy tissue resulting from exceeding international accepted tolerance levels or lack of tumor control due to a low dose delivered to the target volume. The goal for the uncertainty of the dose delivered to the target volume would be around 5% (at the level of one standard deviation), to assure the effectiveness of the radiotherapy treatment. This also takes into account the uncertainties in dose calculation algorithms. In current brachytherapy (BT) treatments, the procedures to determine the absorbed dose imparted to the patient are not based on absorbed dose standards, but are based on measurements traceable to air kerma standards. In fact, the recommended quantity for the calibration of BT gamma ray sources is the reference air kerma rate, KR, defined as the kerma rate to air, in air, at the reference distance of 1 m from the radioactive source, corrected for air attenuation and scattering. The absorbed dose around a BT source is currently calculated by applying the formalism of the international AAPM Task Group 43 protocol and its update. This protocol is based on the air kerma strength, SK, a quantity that is numerically equivalent to KR, at a distance of 1 m from the source. The dose rate constant Λ converts the air-kerma strength SK to the absorbed dose rate to water, D.(r0,θ0), in water at the reference position: D.(r0,θ0) = SK·A (1). Recently, a lower limit of 2,50 % was obtained for the estimated overall uncertainty (at the level of one standard deviation) on measurements of D.(r0,θ0) due to a HDR 192I BT source based on equation (1). However, in most cases the determination of 5K is typically affected by an uncertainty within 0,8 % (at the level of one standard

  11. Self-potential time series analysis in a seismic area of the Southern Apennines: preliminary results

    Directory of Open Access Journals (Sweden)

    V. Tramutoli

    1994-06-01

    Full Text Available The self-potential time series recorded during the period May 1991 - August 1992 by an automatic station, located in a seismic area of Southern Apennines, is analyzed. We deal with the spectral and the statistical features of the electrotellurie precursors: they can play a major role in the approach to seismic prediction. The time-dynamics of the experimental time series is investigated, the cyclic components and the time trends are removed. In particular we consider the influence of external noise, related to anthropic activities and meteoclimatic parameters, and pick out the anomalies from the residual series. Finally we show the preliminary results of the correlation between the anomalies in the time patterns of self-potential data and the earthquakes which occurred in the area.

  12. Raman scattering investigation of the water-bridge phenomenon: Some preliminary results

    Directory of Open Access Journals (Sweden)

    Francesco Aliotta

    2010-09-01

    Full Text Available A floating water-bridge is formed if a high-voltage direct current is applied between two beakers filled of chemically pure water. Raman spectra of the OH-stretching region have been obtained at ambient condition of temperature and pressure. These preliminary results seem to indicate that the hydrogen-bond structure is only slightly modified by the presence of the electric field applied to form the floating water-bridge in agreement with recent neutron scattering investigation. In fact, the polarized Raman spectrum of the pure water and of the water-bridge is almost superimposable. We are planning to carry out further spectroscopic analysis, at different thermodynamic conditions, for better understanding the role played by the hydrogen-bond in driving the formation of the floating water-bridge.

  13. Preliminary Results from VOC measurements in the Lower Fraser Valley in July/Aug 2012

    Science.gov (United States)

    Schiller, C. L.; Jones, K.; Vingarzan, R.; Leaitch, R.; Macdonald, A.; Osthoff, H. D.; Reid, K.

    2012-12-01

    In July/August 2012, a pilot study looking at the effect of ClNO2 production on the ozone concentrations in the lower Fraser valley near Abbotsford, BC was conducted. The lower Fraser valley in British Columbia Canada has some of the highest ozone concentrations and visibility issues in Canada. Abbotsford is located approximately 80 kms east of Vancouver, BC and approximately 30 kms from the ocean. The site was located in a largely agricultural area with fruit farms (raspberries and blueberries) and poultry barns predominating. During the study biogenic and anthropogenic VOCs were measured in situ using a GCMS/FID with hourly samples. Particle composition was measured using an ACSM and size distribution using an SMPS. Preliminary results from the study will be discussed.

  14. Polarimetry at 1.3 mm using MILLIPOL - methods and preliminary results for Orion

    International Nuclear Information System (INIS)

    This paper describes a polarimeter for use at wavelengths near 1 mm, designed to be self-contained and portable. Only minor modifications should be required to adapt this instrument for use on any of several millimeter and submillimeter telescopes. The polarimeter system and data-taking techniques are described, and a preliminary measurement is reported of the polarized dust emission from the Orion KL region at 1.3 mm using the NRAO 12 m telescope. The results are similar to previous polarization measurements of Orion at far-infrared and submillimeter wavelengths. The magnetic field direction implied by the polarization position angle is parallel to that found in the surrounding Orion region using optical and near- to midinfrared polarimetric techniques. 17 references

  15. Microwave frequency sweep interferometer for plasma density measurements in ECR ion sources: Design and preliminary results

    Science.gov (United States)

    Torrisi, Giuseppe; Mascali, David; Neri, Lorenzo; Leonardi, Ornella; Sorbello, Gino; Celona, Luigi; Castro, Giuseppe; Agnello, Riccardo; Caruso, Antonio; Passarello, Santi; Longhitano, Alberto; Isernia, Tommaso; Gammino, Santo

    2016-02-01

    The Electron Cyclotron Resonance Ion Sources (ECRISs) development is strictly related to the availability of new diagnostic tools, as the existing ones are not adequate to such compact machines and to their plasma characteristics. Microwave interferometry is a non-invasive method for plasma diagnostics and represents the best candidate for plasma density measurement in hostile environment. Interferometry in ECRISs is a challenging task mainly due to their compact size. The typical density of ECR plasmas is in the range 1011-1013 cm-3 and it needs a probing beam wavelength of the order of few centimetres, comparable to the chamber radius. The paper describes the design of a microwave interferometer developed at the LNS-INFN laboratories based on the so-called "frequency sweep" method to filter out the multipath contribution in the detected signals. The measurement technique and the preliminary results (calibration) obtained during the experimental tests will be presented.

  16. Microwave frequency sweep interferometer for plasma density measurements in ECR ion sources: Design and preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Torrisi, Giuseppe [INFN - Laboratori Nazionali del Sud, Via S. Sofia 62, 95125 Catania (Italy); University Mediterranea of Reggio Calabria, Reggio Calabria (Italy); Mascali, David; Neri, Lorenzo; Leonardi, Ornella; Celona, Luigi; Castro, Giuseppe; Agnello, Riccardo; Caruso, Antonio; Passarello, Santi; Longhitano, Alberto; Gammino, Santo [INFN - Laboratori Nazionali del Sud, Via S. Sofia 62, 95125 Catania (Italy); Sorbello, Gino [INFN - Laboratori Nazionali del Sud, Via S. Sofia 62, 95125 Catania (Italy); University of Catania, Catania, Italy and INFN-LNS, Catania (Italy); Isernia, Tommaso [University Mediterranea of Reggio Calabria, Reggio Calabria (Italy)

    2016-02-15

    The Electron Cyclotron Resonance Ion Sources (ECRISs) development is strictly related to the availability of new diagnostic tools, as the existing ones are not adequate to such compact machines and to their plasma characteristics. Microwave interferometry is a non-invasive method for plasma diagnostics and represents the best candidate for plasma density measurement in hostile environment. Interferometry in ECRISs is a challenging task mainly due to their compact size. The typical density of ECR plasmas is in the range 10{sup 11}–10{sup 13} cm{sup −3} and it needs a probing beam wavelength of the order of few centimetres, comparable to the chamber radius. The paper describes the design of a microwave interferometer developed at the LNS-INFN laboratories based on the so-called “frequency sweep” method to filter out the multipath contribution in the detected signals. The measurement technique and the preliminary results (calibration) obtained during the experimental tests will be presented.

  17. Preliminary Results on the Experimental Investigation of the Structure Functions of Bound Nucleons

    Energy Technology Data Exchange (ETDEWEB)

    Bodek, Arie [University of Rochester, Rochester, NY

    2015-09-01

    We present preliminary results on an experimental study of the nuclear modification of the longitudinal (σL) and transverse (σT) structure functions of nucleons bound in nuclear targets. The origin of these modifications (commonly referred as as the EMC effect) is not fully understood. Our measurements of R= σLT for nuclei (RA) and for deuterium (RD) indicate that nuclear modifications of the structure functions of bound nucleons are different for the longitudinal and transverse structure functions, and that contrary to expectation from several theoretical models, RA < RD.

  18. Preliminary results for the diffusion of water into fibre optic oil well sensors

    International Nuclear Information System (INIS)

    Preliminary results are presented on a measurement technique for determination of water penetration into fibre optic sensors under high pressure, high temperature conditions. Both fibre optic sensors and communication fibres were subjected to prolonged treatment in heavy water at temperatures up to 250 deg. C and pressures of 40 bar. Deuterium penetration is measured by a nuclear reaction technique based on a 3He micro-focussed ion beam, which permits two-dimensional mapping of the deuterium penetration into cleaved fibres. Water penetration can be detected whilst still confined to the cladding, well before any optical effects become apparent, permitting prediction of likely fibre lifetime under down-hole conditions after realistic experimental times

  19. Microwave frequency sweep interferometer for plasma density measurements in ECR ion sources: Design and preliminary results

    International Nuclear Information System (INIS)

    The Electron Cyclotron Resonance Ion Sources (ECRISs) development is strictly related to the availability of new diagnostic tools, as the existing ones are not adequate to such compact machines and to their plasma characteristics. Microwave interferometry is a non-invasive method for plasma diagnostics and represents the best candidate for plasma density measurement in hostile environment. Interferometry in ECRISs is a challenging task mainly due to their compact size. The typical density of ECR plasmas is in the range 1011–1013 cm−3 and it needs a probing beam wavelength of the order of few centimetres, comparable to the chamber radius. The paper describes the design of a microwave interferometer developed at the LNS-INFN laboratories based on the so-called “frequency sweep” method to filter out the multipath contribution in the detected signals. The measurement technique and the preliminary results (calibration) obtained during the experimental tests will be presented

  20. Radiotherapy of heterotopic bone formation in patients with paraplegia. Preliminary results

    International Nuclear Information System (INIS)

    In 20 patients with paralysis, 25 regions were irradiated with (mostly) 10 Gy in single fractions of 2 to 2.5 Gy using 8 MW photons. In 15 patients radiotherapy was performed as a primary treatment in the status of myositis; 7 patients were treated after (subtotal) resection of already manifest ossifications (2 patients were treated twice, primarily and postoperatively). In a minimum follow-up 12 weeks, none of the 20 irradiated patients showed any progression of the developing or already manifest ossification; thus mobilisation and rehabilitation could be carried out as desired. No side effects occurred. The preliminary results of the present study suggest that radiotherapy is an effective local treatment with minimal side effects for the prevention of heterotopic bone formation in patients with paraplegia. (orig.)

  1. Preliminary interpretation of the Libretto-2 experimental results in terms of tritium permeation barrier efficiency

    International Nuclear Information System (INIS)

    Within the framework of a European Community programme aiming at the development of a water-cooled lithium-lead (Pb17Li) blanket concept for a demonstration fusion reactor, important experimental works are devoted to the development of efficient tritium permeation barriers. Among them, in-pile tests (LIBRETTO experiments) with closed capsules containing stagnant Pb17Li are intended to assess under irradiation the efficiency of these barriers. In this paper, a method for interpreting LIBRETTO data is presented, which relies on the use of a 2-dimensional finite element simulation model exploiting the analogy between tritium migration and heat conduction. Preliminary results obtained with this model are also discussed, which seem to indicate that, under conditions comparable with the experiment, the permeation barrier tested in LIBRETTO-2 would reduce tritium permeation by a factor of about 80

  2. Preliminary interpretation of the LIBRETTO-2 experimental results in terms of tritium permeation barrier efficiency

    International Nuclear Information System (INIS)

    Within the framework of a European Community program aiming at the development of a water-cooled lithium-lead (Pb17Li) blanket concept for a demonstration fusion reactor [1,2], experimental works are devoted to the development of efficient tritium permeation barriers. These works include in-pile tests (LIBRETTO experiments) with closed steel capsules containing stagnant Pb17Li, intended to assess under irradiation the efficiency of these barriers. In this paper, a method for interpreting LIBRETTO data is presented, which relies on the use of a 2-dimensional finite element simulation model exploiting the analogy between tritium migration and heat conduction. Preliminary results obtained with this model are also discussed, which seem to indicate that, under conditions comparable with the experiment, the permeation barrier tested in LIBRETTO-2 would reduce tritium permeation by about two orders of magnitude. (orig.)

  3. Fuzzy-logic-based hybrid locomotion mode classification for an active pelvis orthosis: Preliminary results.

    Science.gov (United States)

    Yuan, Kebin; Parri, Andrea; Yan, Tingfang; Wang, Long; Munih, Marko; Vitiello, Nicola; Wang, Qining

    2015-08-01

    In this paper, we present a fuzzy-logic-based hybrid locomotion mode classification method for an active pelvis orthosis. Locomotion information measured by the onboard hip joint angle sensors and the pressure insoles is used to classify five locomotion modes, including two static modes (sitting, standing still), and three dynamic modes (level-ground walking, ascending stairs, and descending stairs). The proposed method classifies these two kinds of modes first by monitoring the variation of the relative hip joint angle between the two legs within a specific period. Static states are then classified by the time-based absolute hip joint angle. As for dynamic modes, a fuzzy-logic based method is proposed for the classification. Preliminary experimental results with three able-bodied subjects achieve an off-line classification accuracy higher than 99.49%. PMID:26737144

  4. Microwave frequency sweep interferometer for plasma density measurements in ECR ion sources: Design and preliminary results.

    Science.gov (United States)

    Torrisi, Giuseppe; Mascali, David; Neri, Lorenzo; Leonardi, Ornella; Sorbello, Gino; Celona, Luigi; Castro, Giuseppe; Agnello, Riccardo; Caruso, Antonio; Passarello, Santi; Longhitano, Alberto; Isernia, Tommaso; Gammino, Santo

    2016-02-01

    The Electron Cyclotron Resonance Ion Sources (ECRISs) development is strictly related to the availability of new diagnostic tools, as the existing ones are not adequate to such compact machines and to their plasma characteristics. Microwave interferometry is a non-invasive method for plasma diagnostics and represents the best candidate for plasma density measurement in hostile environment. Interferometry in ECRISs is a challenging task mainly due to their compact size. The typical density of ECR plasmas is in the range 10(11)-10(13) cm(-3) and it needs a probing beam wavelength of the order of few centimetres, comparable to the chamber radius. The paper describes the design of a microwave interferometer developed at the LNS-INFN laboratories based on the so-called "frequency sweep" method to filter out the multipath contribution in the detected signals. The measurement technique and the preliminary results (calibration) obtained during the experimental tests will be presented. PMID:26932081

  5. Equity in transportation: new approach in transport planning – preliminary results of case study in Cracow

    Directory of Open Access Journals (Sweden)

    Lidia ZAKOWSKA

    2014-09-01

    Full Text Available The goal of the paper is to present the concept of equity as a new approach in transport and land-use planning. This concept is consistent with the objectives of sustainable development and it is becoming more common in European and world literature. Understanding the idea of equity in the context of the transport system development is very important in creating sustainable cities and regions without discriminating any social groups and creating a cohesive society not exposed to social exclusion due to lack of access to primary and secondary activities. The paper presents some results of the preliminary analysis on transport equity in Cracow. The basic equity level which has been considered here concerns senior citizens, older people living in Cracow area, in terms of their accessibility to transport infrastructure. Taking into account living conditions of elderly pedestrians, contour measures were used, in order to determine accessibility as equity indicator.

  6. THE BREED TRACEABILITY OF SHEEP MEAT BY USING MOLECULAR GENETICS METHODS: PRELIMINARY RESULTS

    Directory of Open Access Journals (Sweden)

    A. Bramante

    2011-04-01

    Full Text Available Safety and quality foods of animal origin are extremely important for consumers. The aim of this work was to evaluate the feasibility of a method to track the breed origin of sheep meat all along the production chain using molecular genetics tools. A total of 800 samples evenly distributed among seven Italian sheep breeds have been typed at 19 STR markers, together with 90 samples from both imported sheep animals and local crossbred animals withdrawn at slaughterhouses. A maximum likelihood assignment test was adopted to evaluate STR ability to allocate samples to their true breed of origin. Sarda animals were all correctly allocated, as well as more than 98% of samples from the other breeds. Only slightly worst allocation performances were observed for imported and crossbred animals. Preliminary results seem quite promising, though further analyses will be needed in order to better understand the statistical power of such an assignment test before implementation in the sheep meat production chain.

  7. Description and preliminary results of a meteorological network for high altitudes

    Science.gov (United States)

    Duran-Montejano, L.

    2003-04-01

    A high resolution meteorological network has been implemented for monitoring temperature, relative humidity and precipitation at very high altitudes. The system is made up by a specially designed “terrestrial buoy” for high altitudes of very low power requirement and great robustness. The complete system consists of seven of these terrestrial buoys installed in less than 20 Km2 and with more than one measuring point per 150 m of altitude difference. A brief description of the system is presented with some of the preliminary results, including spatial generalization of the point meteorological data to the whole domain of the network using a simple spatial interpolation algorithm and a high resolution terrain digital model in order to be used as inputs for eco-biological models.

  8. Preliminary dating results for ancient ceramics from Romania by means of thermoluminescence

    International Nuclear Information System (INIS)

    The preliminary results from dating two types of ancient ceramic from Romania by means of thermoluminescence are presented. The measurements are the first TL dating in a Romanian laboratory. Pottery collected from two Eneolithical sites (Petresti culture) and two types of Roman ceramic were investigated using the quartz inclusion technique and an additive dose procedure. The annual dose was estimated using instrumental neutron activation and the calculated values ranged between 2.7 and 3.7mGy per annum. The analysis yielded reproductible growth curves and the ages obtained range between 5321+/-257 and 5850+/-509y in good agreement with the dates assigned by archaeologists (5000-6000y) for the Neolithic samples. The ages for the Roman samples, 1790+/-125 and 1850+/-170y were also consistent with their known ages

  9. Instrumentation development for space debris optical observation system in Indonesia: Preliminary results

    Science.gov (United States)

    Dani, Tiar; Rachman, Abdul; Priyatikanto, Rhorom; Religia, Bahar

    2015-09-01

    An increasing number of space junk in orbit has raised their chances to fall in Indonesian region. So far, three debris of rocket bodies have been found in Bengkulu, Gorontalo and Lampung. LAPAN has successfully developed software for monitoring space debris that passes over Indonesia with an altitude below 200 km. To support the software-based system, the hardware-based system has been developed based on optical instruments. The system has been under development in early 2014 which consist of two systems: the telescopic system and wide field system. The telescopic system uses CCD cameras and a reflecting telescope with relatively high sensitivity. Wide field system uses DSLR cameras, binoculars and a combination of CCD with DSLR Lens. Methods and preliminary results of the systems will be presented.

  10. Preliminary results of a lidar-dial integrated system for the automatic detection of atmospheric pollutants

    Science.gov (United States)

    Gaudio, P.; Gelfusa, M.; Richetta, M.

    2012-11-01

    In the last decades, atmospheric pollution in urban and industrial areas has become a major concern of both developed and developing countries. In this context, surveying relative large areas in an automatic way is an increasing common objective of public health organisations. The Lidar-Dial techniques are widely recognized as a cost-effective approach to monitor large portions of the atmosphere and, for example, they have been successful applied to the early detection of forest fire. The studies and preliminary results reported in this paper concern the development of an integrated Lidar-Dial system able to detect sudden releases in air of harmful and polluting substances. The propose approach consists of continuous monitoring of the area under surveillance with a Lidar type measurement (by means of a low cost system). Once a significant increase in the density of a pollutant is revealed, the Dial technique is used to identify the released chemicals. In this paper, the specifications of the proposed station are discussed. The most stringent requirement is the need for a very compact system with a range of at least 600-700 m. Of course, the optical wavelengths must be in an absolute eye-safe range for humans. A conceptual design of the entire system is described and the most important characteristic of the main elements are provided. In particular the capability of the envisaged laser sources, Nd:YAG and CO2 lasers, to provide the necessary quality of the measurements is carefully assessed. Since the detection of dangerous substances must be performed in an automatic way, the monitoring station will be equipped with an adequate set of control and communication devices for independent autonomous operation. The results of the first preliminary tests illustrate the potential of the chosen approach.

  11. Preliminary results of 3-dimensional conformal radiotherapy for primary unresectable hepatocellular carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Keum, Ki Chang; Park, Hee Chul; Seong, Jin Sil; Chang, Sei Kyoung; Han, Kwang Hyub; Chon, Chae Yoon; Moon, Young Myoung; Kim, Gwi Eon; Suh, Chang Ok [Hallym University College of Medicine, Seoul (Korea, Republic of)

    2002-06-15

    The purpose of this study was to determine the potential role of three-dimensional conformal radiotherapy (3D-CRT) in the treatment of primary unresectable hepatocellular carcinoma. The preliminary results on the efficacy and the toxicity of 3D-CRT are reported. Seventeen patients were enrolled in this study, which was conducted prospectively from January 1995 to June 1997. The exclusion criteria included the presence of extrahepatic metastasis, liver cirrhosis of Child-Pugh classification C, tumors occupying more than two thirds of the entire liver, and a performance status of more than 3 on the ECOG scale. Two patients were treated with radiotherapy only while the remaining 15 were treated with combined transcatheter arterial chemoembolization. Radiotherapy was given to the field including the tumor plus a 1.5 cm margin using a 3D-CRT technique. The radiation dose ranged from 36 {approx} 60 Gy (median: 59.4 Gy). Tumor response was based on a radiological examination such as the CT scan, MR imaging, and hepatic artery angiography at 4 {approx} 8 weeks following the completion of treatment. The acute and subacute toxicities were monitored. An objective response was observed in 11 out of 17 patients, giving a response rate of 64.7%. The actuarial survival rate at 2 years was 21.2% from the start of radiotherapy (median survival; 19 months). Six patients developed a distant metastasis consisting of a lung metastasis in 5 patients and bone metastasis in one. The complications related to 3D-CRT were gastro-duodenitis ({>=} grade 2) in 2 patients. There were no treatment related deaths and radiation induced hepatitis. The preliminary results show that 3D-CRT is a reliable and effective treatment modality for primary unresectable hepatocellular carcinoma compared to other conventional modalities. Further studies to evaluate the definitive role of the 3D-CRT technique in the treatment of primary unresectable hepatocellular carcinoma are needed.

  12. Preliminary results of 3-dimensional conformal radiotherapy for primary unresectable hepatocellular carcinoma

    International Nuclear Information System (INIS)

    The purpose of this study was to determine the potential role of three-dimensional conformal radiotherapy (3D-CRT) in the treatment of primary unresectable hepatocellular carcinoma. The preliminary results on the efficacy and the toxicity of 3D-CRT are reported. Seventeen patients were enrolled in this study, which was conducted prospectively from January 1995 to June 1997. The exclusion criteria included the presence of extrahepatic metastasis, liver cirrhosis of Child-Pugh classification C, tumors occupying more than two thirds of the entire liver, and a performance status of more than 3 on the ECOG scale. Two patients were treated with radiotherapy only while the remaining 15 were treated with combined transcatheter arterial chemoembolization. Radiotherapy was given to the field including the tumor plus a 1.5 cm margin using a 3D-CRT technique. The radiation dose ranged from 36 ∼ 60 Gy (median: 59.4 Gy). Tumor response was based on a radiological examination such as the CT scan, MR imaging, and hepatic artery angiography at 4 ∼ 8 weeks following the completion of treatment. The acute and subacute toxicities were monitored. An objective response was observed in 11 out of 17 patients, giving a response rate of 64.7%. The actuarial survival rate at 2 years was 21.2% from the start of radiotherapy (median survival; 19 months). Six patients developed a distant metastasis consisting of a lung metastasis in 5 patients and bone metastasis in one. The complications related to 3D-CRT were gastro-duodenitis (≥ grade 2) in 2 patients. There were no treatment related deaths and radiation induced hepatitis. The preliminary results show that 3D-CRT is a reliable and effective treatment modality for primary unresectable hepatocellular carcinoma compared to other conventional modalities. Further studies to evaluate the definitive role of the 3D-CRT technique in the treatment of primary unresectable hepatocellular carcinoma are needed

  13. Brachytherapy for elderly patients with stage II tongue cancer

    International Nuclear Information System (INIS)

    In treatment choices of stage II (T2N0M0) tongue cancer, brachytherapy is less invasive and superior in function preservation, therefore its role is more important in elderly patients. The aim of this study was to evaluate treatment results and morbidity of brachytherapy for elderly patients with stage II tongue cancer. Between 1980 and 2001, 198 patients with stage II tongue cancer were treated with brachytherapy at Hiroshima University Hospital. Patient ages ranged from 21 to 89 years old (median: 62 years old). Patients were divided into three groups as follows: 119 patients younger than 65 years old (Non-Elderly group), 53 patients between 65 and 75 years old (Junior Elderly group), and 26 patients 75 years or older (Senior Elderly group). Radiotherapy was performed in 101 patients with brachytherapy alone, and in 97 patients with brachytherapy and external radiotherapy. Chemotherapy was also performed in 77 patients. Follow-up period ranged from 4 to 243 months (median: 55 months). The 5-year local control rate was 85% in the Non-Elderly group, 85% in the Junior Elderly group and 81% in the Senior Elderly group. There was no significant difference among these groups. The 5-year cause-specific survival rate was 85%, 81% and 70% respectively. The Senior Elderly group showed poorer cause-specific survival rate than the other two groups (p=0.03). There was also a tendency of higher incidence of neck metastasis and low salvage rate by neck dissection in the Senior Elderly group. Although the Senior Elderly group showed poorer cause-specific survival rate, the local control rate was similar to those of the other two groups. Brachytherapy is an effective treatment option for elderly patients with stage II tongue cancer. (author)

  14. Parameterization of brachytherapy source phase space file for Monte Carlo-based clinical brachytherapy dose calculation

    International Nuclear Information System (INIS)

    A common approach to implementing the Monte Carlo method for the calculation of brachytherapy radiation dose deposition is to use a phase space file containing information on particles emitted from a brachytherapy source. However, the loading of the phase space file during the dose calculation consumes a large amount of computer random access memory, imposing a higher requirement for computer hardware. In this study, we propose a method to parameterize the information (e.g., particle location, direction and energy) stored in the phase space file by using several probability distributions. This method was implemented for dose calculations of a commercial Ir-192 high dose rate source. Dose calculation accuracy of the parameterized source was compared to the results observed using the full phase space file in a simple water phantom and in a clinical breast cancer case. The results showed the parameterized source at a size of 200 kB was as accurate as the phase space file represented source of 1.1 GB. By using the parameterized source representation, a compact Monte Carlo job can be designed, which allows an easy setup for parallel computing in brachytherapy planning. (paper)

  15. Parameterization of brachytherapy source phase space file for Monte Carlo-based clinical brachytherapy dose calculation

    Science.gov (United States)

    Zhang, M.; Zou, W.; Chen, T.; Kim, L.; Khan, A.; Haffty, B.; Yue, N. J.

    2014-01-01

    A common approach to implementing the Monte Carlo method for the calculation of brachytherapy radiation dose deposition is to use a phase space file containing information on particles emitted from a brachytherapy source. However, the loading of the phase space file during the dose calculation consumes a large amount of computer random access memory, imposing a higher requirement for computer hardware. In this study, we propose a method to parameterize the information (e.g., particle location, direction and energy) stored in the phase space file by using several probability distributions. This method was implemented for dose calculations of a commercial Ir-192 high dose rate source. Dose calculation accuracy of the parameterized source was compared to the results observed using the full phase space file in a simple water phantom and in a clinical breast cancer case. The results showed the parameterized source at a size of 200 kB was as accurate as the phase space file represented source of 1.1 GB. By using the parameterized source representation, a compact Monte Carlo job can be designed, which allows an easy setup for parallel computing in brachytherapy planning.

  16. Brachytherapy in vulvar cancer: analysis of 18 patients

    International Nuclear Information System (INIS)

    INTRODUCTION: Vulvar cancer is a rather common neoplasm in elderly patients. Surgery, followed eventually by postoperative radiotherapy, is the treatment of choice. The results of exclusive radiotherapy (external beam irradiation and/or brachytherapy) are not well defined and in the recent literature only small series are reported. Radiotherapy however is the only therapeutic option in patients who are not fit for radical surgery. It is thus necessary to review its indications and its modalities. PATIENTS METHODS AND RESULTS: From 1990 to 1994 18 pts with a diagnosis of squamous cell carcinoma of the vulva have been submitted to brachytherapy. Age ranged from 60 to 92 years (mean age 76, 1 ys). 14 pts were treated at diagnosis (11 pts) or for recurrent disease after surgery (3 pts). In 8 of them brachytherapy (total dose 35-45 Gy, dose rate: 0,4-0,78 Gy/h) was preceded by external beam irradiation (Co60 or electron beam, 40-50 Gy to primary and inguinal nodes); 6 pts were treated with brachytherapy alone (58-60 Gy; dose rate 0,44-0,63 Gy/h). 4 pts underwent to brachytherapy alone for local recurrence after surgery and postoperative radiotherapy (total dose 45-60 Gy; dose rate 0,37-0,49 Gy/h). Brachytherapy was always performed with 192 Ir. Plastic tubes (2 to 5 lines) were used for single plane implantation of small exophytic lesions limited to the labia (8 cases); a perineal template (10 cases) was employed in lesions extended to the vaginal mucosa or involving the clitoris or the area of the perineum. (10(14)) pts treated at diagnosis are alive and free from local recurrence after 11-48 mos. 3 of them, treated with brachytherapy alone, have presented a nodal recurrence in the groin after 14, 15 and 27 mos. respectively. All of them are alive and free from disease after surgery and external radiotherapy. None of the pts treated for recurrent disease after surgery + external beam radiotherapy has achieved a local control. CONCLUSION: Brachytherapy alone or

  17. Preliminary results on photometric properties of materials at the Sagan Memorial Station, Mars

    Science.gov (United States)

    Johnson, J. R.; Kirk, R.; Soderblom, L.A.; Gaddis, L.; Reid, R.J.; Britt, D.T.; Smith, P.; Lemmon, M.; Thomas, N.; Bell, J.F., III; Bridges, N.T.; Anderson, R.; Herkenhoff, K. E.; Maki, J.; Murchie, S.; Dummel, A.; Jaumann, R.; Trauthan, F.; Arnold, G.

    1999-01-01

    Reflectance measurements of selected rocks and soils over a wide range of illumination geometries obtained by the Imager for Mars Pathfinder (IMP) camera provide constraints on interpretations of the physical and mineralogical nature of geologic materials at the landing site. The data sets consist of (1) three small "photometric spot" subframed scenes, covering phase angles from 20?? to 150??; (2) two image strips composed of three subframed images each, located along the antisunrise and antisunset lines (photometric equator), covering phase angles from ???0?? to 155??; and (3) full-image scenes of the rock "Yogi," covering phase angles from 48?? to 100??. Phase functions extracted from calibrated data exhibit a dominantly backscattering photometric function, consistent with the results from the Viking lander cameras. However, forward scattering behavior does appear at phase angles >140??, particularly for the darker gray rock surfaces. Preliminary efforts using a Hapke scattering model are useful in comparing surface properties of different rock and soil types but are not well constrained, possibly due to the incomplete phase angle availability, uncertainties related to the photometric function of the calibration targets, and/or the competing effects of diffuse and direct lighting. Preliminary interpretations of the derived Hapke parameters suggest that (1) red rocks can be modeled as a mixture of gray rocks with a coating of bright and dark soil or dust, and (2) gray rocks have macroscopically smoother surfaces composed of microscopically homogeneous, clear materials with little internal scattering, which may imply a glass-like or varnished surface. Copyright 1999 by the American Geophysical Union.

  18. Interstitial brachytherapy for carcinoma of the base of tongue using a high dose rate 192Ir remote afterloader

    International Nuclear Information System (INIS)

    We have applied an interstitial brachytherapy employing a high dose rate 192Ir remote afterloader to five patients with cancer of the base of tongue since December 1994. Insertion of applicators was carried out with tracheotomy under general anesthesia. Brachytherapy was delivered twice a day with a 6-hour interval. Irradiation dose was estimated at the point of 5 mm from outer applicators. HDR brachytherapy was well tolerated for 4-5 days in all patients and acute radiation reaction was minimal. Local control were observed in two cases. In conclusion, our preliminary experience suggests that HDR brachytherapy may be an option in the radiotherapy for carcinoma of the base of tongue. Optimal dose-fractionation protocol should be established. (author)

  19. Dose-volume histogram parameters of high-dose-rate brachytherapy for Stage I-II cervical cancer (≤4cm) arising from a small-sized uterus treated with a point A dose-reduced plan

    International Nuclear Information System (INIS)

    We investigated the rectal dose-sparing effect and tumor control of a point A dose-reduced plan in patients with Stage I-II cervical cancer (≤4 cm) arising from a small-sized uterus. Between October 2008 and August 2011, 19 patients with Stage I-II cervical cancer (≤4 cm) were treated with external beam radiotherapy (EBRT) for the pelvis and CT-guided brachytherapy. Seven patients were treated with brachytherapy with standard loading of source-dwell positions and a fraction dose of 6 Gy at point A (conventional brachy-plan). The other 12 patients with a small uterus close to the rectum or small intestine were treated with brachytherapy with a point A dose-reduction to match D2cc of the rectum and <6 Gy as the dose constraint ('point A dose-reduced plan') instead of the 6-Gy plan at point A ('tentative 6-Gy plan'). The total doses from EBRT and brachytherapy were added up and normalized to a biological equivalent dose of 2 Gy per fraction (EQD2). The median doses to the high-risk clinical target volume (HR-CTV) D90 in the conventional brachy-plan, tentative 6-Gy plan and point A dose-reduced plan were 62 GyEQD2, 80 GyEQD2 and 64 GyEQD2, respectively. The median doses of rectal D2cc in the corresponding three plans were 42 GyEQD2, 62 GyEQD2 and 51 GyEQD2, respectively. With a median follow-up period of 35 months, three patients developed Grade-1 late rectal complications and no patients developed local recurrence. Our preliminary results suggested that CT-guided brachytherapy using an individualized point A dose-reduced plan might be useful for reducing late rectal complications while maintaining primary tumor control. (author)

  20. Study of factors influencing dose distribution of brachytherapy in cervical cancer

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Objective To study the factors which influence the dose distribution of brachytherapy in cervical cancer.Methods Ninety-five patients with cervical cancer Ⅱ-Ⅲb received fundamental radiation therapy including brachytherapy in our department from Aug.2004 to Nov.2005.The deviation of isodose curve of brachytherapy was based on A-B reference system,and the deviation of dose was defined by measuring in a practical standard body model.Results The factors influencing isodose offset significantly were parametrial...

  1. IBIS preliminary results on Cygnus X-1 spectral and temporal characteristics

    CERN Document Server

    Bazzano, A; Capitanio, F; Santo, M D; Ubertini, P; Zdziarski, A A; Cocco, G D; Falanga, M; Goldoni, P; Goldwurm, A; Laurent, P; Lebrun, F; Malaguti, G; Segreto, A

    2003-01-01

    We report preliminary results of a broadband spectral and temporal study of the black-hole binary Cyg X-1 performed with the IBIS telescope. Cyg X-1 was the first pointed celestial target of IBIS during the INTEGRAL Performance and Verification Phase, 2002 Nov.-Dec., for a total observing time of 2 Ms in both staring and dithering mode. Here, we report on only the staring, on-axis, observation performed in a stable instrument configuration. During the observing period the source was in its characteristic low/hard state, in which a few flares and dips have been detected. The IBIS/ISGRI results demonstrate that the INTEGRAL observatory offers a unique capability for studying correlations between hardness and/or flux in different bands over a wide photon energy range. One of our new results is finding that the hardness-flux correlation changes the sign twice over the 20-220 keV; first from positive to negative at 50 keV, and then back to positive at 120 keV. The former change appears to be due to the spectral cu...

  2. The genetic variability of the Podolica cattle breed from the Gargano area. Preliminary results

    Directory of Open Access Journals (Sweden)

    Dario Cianci

    2010-01-01

    Full Text Available The Podolica cattle breed is autochthonous of Southern Italy and denoted by its particular rusticity. This study presents the preliminary results of the genetic characterization of the Podolica breed using DNA STR markers. A total of 20 microsatellite loci were analysed in 79 individuals reared in the Gargano area. Number of polymorphisms, allele fre- quencies, deviations from Hardy-Weinberg proportions, linkage disequilibrium between loci and genetic similarities between animals were calculated. The results showed a high deficiency of heterozygotes, the observed mean of het- erozygosis being 0.449, whereas the expected mean was 0.766. Many markers showed also deviations from the Hardy- Weinberg proportions and significant linkage disequilibrium between loci. However the genetic similarity within the pop- ulation was low (0.281 and the average number of alleles per locus was high (10, representing a high genetic vari- ability. In order to explain these results, a stratification of the breed in sub-populations with a high interior genetic homo- geneity but markedly differentiated one from each other could be hypothesized; this situation probably derived from non- random mating within each herd (consanguinity and from the lack of exchange of genetic material between the herds. A further study is needed on a wider sample and extending the analysis to FAO-ISAG microsatellite panel in order to con- firm this hypothesis. This could eventually provide the information necessary for the correct management of the repro- ductive schemes and for genomic traceability of meat production.

  3. Preliminary results of local earthquake tomography around Bali, Lombok, and Sumbawa regions

    Energy Technology Data Exchange (ETDEWEB)

    Nugraha, Andri Dian, E-mail: nugraha@gf.itb.ac.id; Puspito, Nanang T; Yudistira, Tedi [Global Geophysical Reserach Group, Faculty of Mining and Petroleum Engineering, Institute of Technology Bandung, JlGanesa 10, Bandung, 40132 (Indonesia); Kusnandar, Ridwan; Sakti, Artadi Pria [Meteorological, Climatological, and Geophysical Agency (MCGA) of Indonesian, Jakarta (Indonesia)

    2015-04-24

    Bali, Sumbawa, and Lombok regions are located in active tectonic influence by Indo-Australia plate subducts beneath Sunda plate in southern part and local back-arc thrust in northern part the region. Some active volcanoes also lie from eastern part of Java, Bali, Lombok and Sumbawa regions. Previous studies have conducted subsurface seismic velocity imaging using regional and global earthquake data around the region. In this study, we used P-arrival time from local earthquake networks compiled by MCGA, Indonesia within time periods of 2009 up to 2013 to determine seismic velocity structure and simultaneously hypocenter adjustment by applying seismic tomography inversion method. For the tomographic inversion procedure, we started from 1-D initial velocity structure. We evaluated the resolution of tomography inversion results through checkerboard test and calculating derivative weigh sum. The preliminary results of tomography inversion show fairly clearly high seismic velocity subducting Indo-Australian and low velocity anomaly around volcano regions. The relocated hypocenters seem to cluster around the local fault system such as back-arc thrust fault in northern part of the region and around local fault in Sumbawa regions. Our local earthquake tomography results demonstrated consistent with previous studies and improved the resolution. For future works, we will determine S-wave velocity structure using S-wave arrival time to enhance our understanding of geological processes and for much better interpretation.

  4. Facial emotional recognition in schizophrenia: preliminary results of the virtual reality program for facial emotional recognition

    Directory of Open Access Journals (Sweden)

    Teresa Souto

    2013-01-01

    Full Text Available BACKGROUND: Significant deficits in emotional recognition and social perception characterize patients with schizophrenia and have direct negative impact both in inter-personal relationships and in social functioning. Virtual reality, as a methodological resource, might have a high potential for assessment and training skills in people suffering from mental illness. OBJECTIVES: To present preliminary results of a facial emotional recognition assessment designed for patients with schizophrenia, using 3D avatars and virtual reality. METHODS: Presentation of 3D avatars which reproduce images developed with the FaceGen® software and integrated in a three-dimensional virtual environment. Each avatar was presented to a group of 12 patients with schizophrenia and a reference group of 12 subjects without psychiatric pathology. RESULTS: The results show that the facial emotions of happiness and anger are better recognized by both groups and that the major difficulties arise in fear and disgust recognition. Frontal alpha electroencephalography variations were found during the presentation of anger and disgust stimuli among patients with schizophrenia. DISCUSSION: The developed program evaluation module can be of surplus value both for patient and therapist, providing the task execution in a non anxiogenic environment, however similar to the actual experience.

  5. Polyurethane-Covered Self-expandable Nitinol Stent for Malignant Biliary Obstruction: Preliminary Results

    International Nuclear Information System (INIS)

    Purpose: To evaluate the immediate and long-term results in ten patients with malignant biliary obstruction using a polyurethane-covered, self-expandable nitinol stent.Methods: A nitinol stent, fully covered with high-elasticity polyurethane, with an unconstrained diameter of 10 mm and a total length of 60-80 mm, was placed transhepatically under fluoroscopic guidance in ten patients. The length of the biliary obstruction varied between 30-50 mm. The follow-up examination included a clinical assessment, serum bilirubin measurement, and ultrasound examinations at one-month intervals in all patients. Results: Initial stent deployment was successful in eight patients. Two patients experienced proximal migration,which was solved by insertion of two, uncovered Wallstents. One patient had the stent removed after two weeks because of severe nausea and vomiting. One patient had delayed migration of the covered stent after 40 weeks. The follow-up duration was 3-40 weeks (Mean: 16.9 weeks). Seven patients died(3-26 weeks) and three patients survived (24-40 weeks). The bilirubin measurements in all patients had significantly decreased one week after stent insertion. The levels of amylase and lipase had did not increase after stent insertion. Conclusions: Apolyurethane-covered, self-expandable nitinol stent can be used effectively and safely in the treatment of malignant biliary obstruction. The preliminary results are favorable, but there is a need for further large studies to determine both long-term survival and patency

  6. Preliminary results of local earthquake tomography around Bali, Lombok, and Sumbawa regions

    International Nuclear Information System (INIS)

    Bali, Sumbawa, and Lombok regions are located in active tectonic influence by Indo-Australia plate subducts beneath Sunda plate in southern part and local back-arc thrust in northern part the region. Some active volcanoes also lie from eastern part of Java, Bali, Lombok and Sumbawa regions. Previous studies have conducted subsurface seismic velocity imaging using regional and global earthquake data around the region. In this study, we used P-arrival time from local earthquake networks compiled by MCGA, Indonesia within time periods of 2009 up to 2013 to determine seismic velocity structure and simultaneously hypocenter adjustment by applying seismic tomography inversion method. For the tomographic inversion procedure, we started from 1-D initial velocity structure. We evaluated the resolution of tomography inversion results through checkerboard test and calculating derivative weigh sum. The preliminary results of tomography inversion show fairly clearly high seismic velocity subducting Indo-Australian and low velocity anomaly around volcano regions. The relocated hypocenters seem to cluster around the local fault system such as back-arc thrust fault in northern part of the region and around local fault in Sumbawa regions. Our local earthquake tomography results demonstrated consistent with previous studies and improved the resolution. For future works, we will determine S-wave velocity structure using S-wave arrival time to enhance our understanding of geological processes and for much better interpretation

  7. Impulsivity in Multiplayer Online Battle Arena Gamers: Preliminary Results on Experimental and Self-Report Measures.

    Science.gov (United States)

    Nuyens, Filip; Deleuze, Jory; Maurage, Pierre; Griffiths, Mark D; Kuss, Daria J; Billieux, Joël

    2016-06-01

    Background and aims Multiplayer Online Battle Arena (MOBA) games have become the most popular type of video games played worldwide, superseding the playing of Massively Multiplayer Online Role-Playing Games and First-Person Shooter games. However, empirical studies focusing on the use and abuse of MOBA games are still very limited, particularly regarding impulsivity, which is an indicator of addictive states but has not yet been explored in MOBA games. In this context, the objective of the present study is to explore the associations between impulsivity and symptoms of addictive use of MOBA games in a sample of highly involved League of Legends (LoL, currently the most popular MOBA game) gamers. Methods Thirty-six LoL gamers were recruited and completed both experimental (Single Key Impulsivity Paradigm) and self-reported impulsivity assessments (s-UPPS-P Impulsive Behavior Scale, Barratt Impulsiveness Scale), in addition to an assessment of problematic video game use (Problematic Online Gaming Questionnaire). Results Results showed links between impulsivity-related constructs and signs of excessive MOBA game involvement. Findings indicated that impaired ability to postpone rewards in an experimental laboratory task was strongly related to problematic patterns of MOBA game involvement. Although less consistent, several associations were also found between self-reported impulsivity traits and signs of excessive MOBA game involvement. Conclusions Despite these results are preliminary and based upon a small (self-selected) sample, the present study highlights potential psychological factors related to the addictive use of MOBA games. PMID:27156376

  8. Preliminary results on timing properties of CVD diamond detectors for MIPs

    International Nuclear Information System (INIS)

    Due to the large band gap, radiation hardness and fast charge collection, the CVD diamond detectors have been investigated and developed in the last decade for possible use as trackers in high luminosity hadron colliders. Recently they have been successfully used for high resolution 'time zero' detectors in heavy ion experiments. The results of preliminary tests on timing properties of CVD diamond detectors for minimum ionizing particles (MIPs) are reported in this contribution. A unpolished CVD sample of 700 μm with a collection distance of about 60 μm was used for these measurements. All the reported results have been obtained using a 90 Sr β source and an applied electric field of ED = 1 V/μm. A low noise, 50 Ω, 3 GHz amplifier developed at GSI has been used. The reference time signal was delivered by a NE102 plastic scintillator. A figure is given showing amplitude - time of flight correlations. An amplitude dependence of the maxima in the time distribution, a reduction of the dispersion going to larger amplitudes and an asymmetry of the distributions with the larger tail towards higher values of the time of flight can be observed. A time spectrum for CVD amplitudes larger than channel 900 is also given. One TDC channel corresponds to 60 psec. The Gaussian fit has been done on selected window such to enhance the contribution of the left side of the time spectra, where the tail is less pronounced. If we subtract quadratically the time resolution of the plastic scintillator estimated to be ≅ 95 psec, a CVD time resolution of 95 psec is obtained.Taking into account the quality of the CVD diamond used in the present tests relative to the performance reached during the last period, a factor of at least 4 in the amplitude can be easily gained. In such conditions we consider that the preliminary results reported here are quite convincing that using high quality CVDs and appropriate electronics for signal processing (including probably some corrections), CVD

  9. Trends in the Utilization of Adjuvant Vaginal Cuff Brachytherapy and/or External Beam Radiation Treatment in Stage I and II Endometrial Cancer: A Surveillance, Epidemiology, and End-Results Study

    International Nuclear Information System (INIS)

    Purpose: The optimal adjuvant radiation treatment for endometrial carcinoma (EC) remains controversial. Adjuvant vaginal cuff brachytherapy (VB) has emerged as an increasingly common treatment modality. However, the time trends for using VB, external beam radiation therapy (EBRT), or combined therapy (VB+EBRT) have not been well characterized. We therefore examined the utilization trends of VB, EBRT, and VB+EBRT for adjuvant RT in International Federation of Gynecologic Oncology (FIGO) stage I and II EC over time. Methods and Materials: We evaluated treatment patterns for 48,122 patients with EC diagnosed between January 1995 and December 2005, using the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) public use database. Chi-squared tests were used to assess differences by radiation type (VB, EBRT, and VB+EBRT) and various demographic and clinical variables. Results: Analyses were limited to 9,815 patients (20.4%) with EC who met the inclusion criteria. Among women who received adjuvant RT, the proportion receiving VB increased yearly (12.9% in 1995 compared to 32.8% in 2005 (p < 0.0001). The increasing use of VB was proportional to the decreasing use of EBRT (56.1% in 1995 to 45.8% in 2005; p < 0.0001) and VB+EBRT (31.0% in 1995 to 21.4% in 2005; p < 0.001). Conclusions: This population-based report demonstrates an increasing trend in the use of VB in the adjuvant setting after hysterectomy for treatment of women with FIGO stage I II EC. VB alone appears to be replacing pelvic EBRT and VB+EBRT therapy in the management of stage I–II EC.

  10. Neoadjuvant androgen deprivation and long-term results for patients with intermediate- and high-risk prostate cancer treated with high-dose rate brachytherapy and external beam radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Pellizzon, Antonio Cassio Assis; Fogaroli, Ricardo Cesar; Silva, Maria Leticia Gobo; Castro, Douglas Guedes; Maia, Maria Conte, E-mail: acapellizzon@hcancer.org.b [Hospital A.C. Camargo, Sao Paulo, SP (Brazil). Radiation Oncology Dept.

    2010-07-01

    Purpose: to evaluate the influence of neoadjuvant androgen deprivation (NAAD) and report the long term biochemical control rates according to the Phoenix Consensus Conference, and prognostic factors of intermediate- (IR) and high-risk (HR) prostate cancer treated with external beam radiotherapy and high-dose-rate brachytherapy (HDR-BT). Methods and materials: between March, 1997 and June, 2005, 184 patients considered IR or HR were treated with localized radiotherapy and HDR-BT at the Department of Radiation Oncology, Hospital A.C. Camargo, Sao Paulo, Brazil. Patient's age, Gleason score, clinical stage, initial PSA value, risk group for biochemical failure, presence of NAAD, doses of radiotherapy and HDR-BT were evaluated. Results: median age and follow-up were 70 years old (range, 47-83) and 74.5 months (range, 24-123 months), respectively. Patients considered IR were 91 (49.4%) and HR 93 (50.6%). Ninety-nine (53.8%) patients had no NAAD. The overall survival at 5 years was 93.6%. The 5-year actuarial biochemical control rates for all patients, IR and HR were 83.4%, 86.2% and 78.8%, respectively, p0.076. On univariate analysis the prognostic factors related to better biochemical control were Gleason score < 6 ng/ml (p= 0.037), radiotherapy dose > 45 Gy (p= 0.011) and HDR-BT dose > 20 Gy (p< 0.001). On multivariate analysis no statistical significant predictive factor related to biochemical control was found. Conclusions: the role of NAAD for IR and HR prostate cancer is still to be defined. HDR-BT combined to external radiotherapy is a successful form of treatment for these patients, with our results comparable to published data. (author)

  11. Trends in the Utilization of Adjuvant Vaginal Cuff Brachytherapy and/or External Beam Radiation Treatment in Stage I and II Endometrial Cancer: A Surveillance, Epidemiology, and End-Results Study

    Energy Technology Data Exchange (ETDEWEB)

    Patel, Mehul K. [Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan (United States); Cote, Michele L. [Karmanos Cancer Institute and Wayne State University, Detroit, Michigan (United States); Ali-Fehmi, Rouba [Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan (United States); Buekers, Thomas; Munkarah, Adnan R. [Department of Women' s Health Services, Division of Gynecologic Oncology, Henry Ford Health System, Detroit, Michigan (United States); Elshaikh, Mohamed A., E-mail: melshai1@hfhs.org [Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan (United States)

    2012-05-01

    Purpose: The optimal adjuvant radiation treatment for endometrial carcinoma (EC) remains controversial. Adjuvant vaginal cuff brachytherapy (VB) has emerged as an increasingly common treatment modality. However, the time trends for using VB, external beam radiation therapy (EBRT), or combined therapy (VB+EBRT) have not been well characterized. We therefore examined the utilization trends of VB, EBRT, and VB+EBRT for adjuvant RT in International Federation of Gynecologic Oncology (FIGO) stage I and II EC over time. Methods and Materials: We evaluated treatment patterns for 48,122 patients with EC diagnosed between January 1995 and December 2005, using the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) public use database. Chi-squared tests were used to assess differences by radiation type (VB, EBRT, and VB+EBRT) and various demographic and clinical variables. Results: Analyses were limited to 9,815 patients (20.4%) with EC who met the inclusion criteria. Among women who received adjuvant RT, the proportion receiving VB increased yearly (12.9% in 1995 compared to 32.8% in 2005 (p < 0.0001). The increasing use of VB was proportional to the decreasing use of EBRT (56.1% in 1995 to 45.8% in 2005; p < 0.0001) and VB+EBRT (31.0% in 1995 to 21.4% in 2005; p < 0.001). Conclusions: This population-based report demonstrates an increasing trend in the use of VB in the adjuvant setting after hysterectomy for treatment of women with FIGO stage I-II EC. VB alone appears to be replacing pelvic EBRT and VB+EBRT therapy in the management of stage I-II EC.

  12. Panoptes: Calibration of a dosimetry system for eye brachytherapy

    International Nuclear Information System (INIS)

    Intraocular cancer is a serious threat to the lives of those that suffer from it. Dosimetry for eye brachytherapy presents a significant challenge due to the inherently steep dose gradients that are needed to treat such small tumours in close proximity to sensitive normal structures. This issue is addressed by providing much needed quality assurance to eye brachytherapy, a novel volumetric dosimetry system, called PANOPTES was developed. This study focuses on the preliminary characterisation and calibration of the system. Using ion beam facilities, the custom, pixelated silicon detector of PANOPTES was shown to have good charge collection uniformity and a well defined sensitive volume. Flat-field calibration was conducted on the device using a 250 kVp orthovoltage beam. Finally, the detector and phantom were simulated with Monte Carlo in Geant4, to create water equivalent dose correction factors for each pixel across a range of angles. - Highlights: • Volumetric detector system produced for plaque brachytherapy. • Orthovoltage, flat-field calibration performed for detector pixels. • Monte Carlo simulation showed mostly little angular deviation across all angles. • Ion beam induced charge collection showed pixels uniform and fully depleted

  13. Multihelix rotating shield brachytherapy for cervical cancer

    International Nuclear Information System (INIS)

    comparison. For all the generated treatment plans, the D90 of the HR-CTV in units of equivalent dose in 2 Gy fractions (EQD2) was escalated until the D2cc (minimum dose to hottest 2 cm3) tolerance of either the bladder (90 Gy3), rectum (75 Gy3), or sigmoid colon (75 Gy3) was reached. Results: Treatment time changed for H-RSBT versus S-RSBT by −7.62% to 1.17% with an average change of −2.8%, thus H-RSBT treatments times tended to be shorter than for S-RSBT. The HR-CTV D90 also changed by −2.7% to 2.38% with an average of −0.65%. Conclusions: H-RSBT is a mechanically feasible delivery technique for use in the curved applicators needed for cervical cancer brachytherapy. S-RSBT and H-RSBT were clinically equivalent for all patients considered, with the H-RSBT technique tending to require less time for delivery

  14. Multihelix rotating shield brachytherapy for cervical cancer

    Energy Technology Data Exchange (ETDEWEB)

    Dadkhah, Hossein [Department of Biomedical Engineering, University of Iowa, 1402 Seamans Center for the Engineering Arts and Sciences, Iowa City, Iowa 52242 (United States); Kim, Yusung; Flynn, Ryan T., E-mail: ryan-flynn@uiowa.edu [Department of Radiation Oncology, University of Iowa, 200 Hawkins Drive, Iowa City, Iowa 52242 (United States); Wu, Xiaodong [Department of Radiation Oncology, University of Iowa, 200 Hawkins Drive, Iowa City, Iowa 52242 and Department of Electrical and Computer Engineering, University of Iowa, 4016 Seamans Center for the Engineering Arts and Sciences, Iowa City, Iowa 52242 (United States)

    2015-11-15

    comparison. For all the generated treatment plans, the D{sub 90} of the HR-CTV in units of equivalent dose in 2 Gy fractions (EQD2) was escalated until the D{sub 2cc} (minimum dose to hottest 2 cm{sup 3}) tolerance of either the bladder (90 Gy{sub 3}), rectum (75 Gy{sub 3}), or sigmoid colon (75 Gy{sub 3}) was reached. Results: Treatment time changed for H-RSBT versus S-RSBT by −7.62% to 1.17% with an average change of −2.8%, thus H-RSBT treatments times tended to be shorter than for S-RSBT. The HR-CTV D{sub 90} also changed by −2.7% to 2.38% with an average of −0.65%. Conclusions: H-RSBT is a mechanically feasible delivery technique for use in the curved applicators needed for cervical cancer brachytherapy. S-RSBT and H-RSBT were clinically equivalent for all patients considered, with the H-RSBT technique tending to require less time for delivery.

  15. Preliminary performance results for the ATLAS RPC test stand in Lecce

    International Nuclear Information System (INIS)

    We present here a preliminary performance analysis of the ATLAS RPC tested at the Lecce cosmic ray testing facility. In this paper we define the operating working point for our detectors and show the distribution of the principal operating parameters

  16. 78 FR 21107 - Circular Welded Carbon Steel Pipes and Tubes from Turkey: Preliminary Results of Countervailing...

    Science.gov (United States)

    2013-04-09

    ... Steel Pipes and Tubes from Turkey (Preliminary Decision Memorandum) from Edward C. Yang, Senior Director... 5084: Allocation of Free Land and Purchase of Land for less than Adequate Remuneration (LTAR) F....

  17. Holocene evolution and sedimentation rate of Alikes Lagoon, Zakynthos island, Western Greece - preliminary results

    Science.gov (United States)

    Avramidis, P.; Kontopoulos, N.

    2009-03-01

    In the present study we present preliminary results of Zakynthos Alikes lagoon, which is one of the most seismically active regions of Greece. In order to estimate - interpret the Holocene evolution of the area and to reconstruct the palaeonvironmental changes, we based on the data of a 21 m sediment core. Sediment types, structure, colour, as well as contact depths and bed characteristics, were recorded in the field. Standarised sedimentological analysis were carried out, on 46 samples including grain size analysis, calculation of moment measures, and micro- and molluscan fossils of 17 selected samples. Moreover, radiocarbon age determinations have been made on individual Cardium shells from two horizons and whole - core Magnetic Susceptibility (MS) measurements were taken. The interpretation of depositional environments suggests a coastal environment (restricted-shallow) with reduced salinity such as a lagoon margin and in a tidal flat and/or marsh particularly. The maximum age of the study sediments is about 8500 BP. The rate of sedimentation between 8280 BP and 5590 BP was 5.3 mm/yr and between 5590 BP and modern times 1.03 mm/yr. The rate of sedimentation was higher until mid-Holocene while decrease after to 1.03 mm/yr, results which are similar to other coastal areas of western Greece.

  18. Holocene evolution and sedimentation rate of Alikes Lagoon, Zakynthos island, Western Greece: preliminary results

    Science.gov (United States)

    Avramidis, P.; Kontopoulos, N.

    2009-07-01

    In the present study we present preliminary results from Alikes lagoon in Zakynthos island, an area that is one of the most seismically active regions of Greece. In order to estimate - interpret the Holocene evolution of the area and to reconstruct the palaeoenvironmental changes, we based on data derived from a 21 m sediment core. Sediment types, structure, colour, as well as contact depths and bed characteristics were recorded in the field. Standarised sedimentological analysis was carried out, on 46 samples including grain size analysis, calculation of moment measures, and micro- and molluscan fossils of 17 selected samples. Moreover, radiocarbon age determinations have been made on individual Cardium shells from two horizons and whole - core Magnetic Susceptibility (MS) measurements were taken. The interpretation of depositional environments suggests a coastal environment (restricted-shallow) with reduced salinity such as a lagoon margin and in a tidal flat and/or marsh particularly. The maximum age of the studied sediments is about 8500 BP. The rate of sedimentation between 8280 BP while 5590 BP was 5.3 mm/yr and between 5590 BP and modern times is on the order of 1.03 mm/yr. These sedimentation rates results are similar to other coastal areas of western Greece.

  19. Preliminary results of a balloon flight of the solar disk sextant

    Science.gov (United States)

    Maier, E.; Twigg, L.; Sofia, S.

    1992-01-01

    Preliminary results of a balloon flight on October 11, 1991, of the solar disk sextant (SDS) experiment are reported. The SDS is an instrument which measures the solar diameter at different orientations with respect to the solar polar axis. Fitting straight lines through two fixed-angle data sets with time as the independent variable yields slopes of (7.1 +/ - 1.5) x 10 exp -3 and (6.7 +/- 1.6) x 10 exp -3/mas s, consistent with the value of 6.47 x 10 exp -3/mas s expected from the earth's approach to the sun due to the orbital motion toward perihelion. Upon the instrument's rotation on its axis a sinusoidal component of the diameter measurement was observed in each rotation cycle, with a variable amplitude of about 150 mas. The present result is epsilon of (5.6 +/- 6.3) x 10 exp -6, about 30 deg offset from the polar-equator position. The absolute diameter obtained by means of the FFT definition is found to be 1919.269 +/- 0.240 arcsec or 1919.131 +/- 0.240 arcsec, depending on the orientation mode of the measurement.

  20. Preliminary results of a national quality audit programme in radiotherapy services in Cuba

    International Nuclear Information System (INIS)

    The current state of radiotherapy in Cuba has allowed to pass to a superior stage in the process of quality assurance, the establishment of a National Quality Audit Program (PNAC). The National Control Center for Medical Devices, as national regulator entity for the control and supervision of the medical devices of the National Health System, is responsible for the implementation of this program. This paper presents the preliminary results of the execution of the PNAC in teletherapy services with isotopic units of 60Co. The audits were carried out according to the methodology settled down in the normalized procedure of operation of the PNAC. The physical aspects related with the treatment were audited, such as: the installation and unit's safety, mechanical and dosimetric aspects of the treatment unit and organizational aspects of the institution quality assurance program. Also carried out, in the clinical aspect, verifications of cases type planned by the qualified personnel of the service. The results corresponding to the determination of the reference dose for each institution were compared with those obtained in a postal audit with the International Atomic Energy Agency. These first audits allowed to evaluate the performance of the institutions' program of quality assurance and a feedback for the setting about to the PNAC. (author)

  1. Application of a PCR method for the diagnosis of ulcerative enteritis: preliminary results

    Directory of Open Access Journals (Sweden)

    Fabrizio Agnoletti

    2010-01-01

    Full Text Available Ulcerative enteritis or “quail disease” is an acute clostridial infection of young birds reported in many avian species, chicken and turkey included. Clostridium colinum is the causative agent of ulcerative enteritis and because of the difficulties bound to the isolation and identification of this bacterium by means of classic bacteriological techniques, its detection appears very hard and the prevalence of this disease could be underestimated. To investigate the diffusion of C. colinum in enteric disease of birds, a recently developed PCR protocol was applied to 42 cultural broths previously inoculated with organs and intestinal samples collected from diseased subjects. PCR-positive broths were cultivated to attempt the isolation of C. colinum. Samples collected from positive birds were subjected to histological examinations. 4 birds (3 broilers chickens and 1 pigeon resulted PCR-positive and, in one case, C. colinum was isolated. Gross and histological lesions of positive birds were compatible with those described in other ulcerative enteritis outbreaks. These preliminary results demonstrates that C. colinum is sporadically implicated in enteric diseases of broiler chickens (14.2%. In addition, the PCR assay proved to be an useful and reliable instrument to support the diagnosis of ulcerative enteritis and to facilitate the isolation of C. colinum.

  2. Biological image construction by using Raman radiation and Pca: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Martinez E, J. C. [IPN, Unidad Profesional Interdisciplinaria de Ingenieria, Campus Guanajuato, Av. Mineral de Valenciana 200, Col. Fracc. Industrial Puerto Interior, 36275 Silao, Guanajuato (Mexico); Cordova F, T. [Universidad de Guanajuato, DIC, Departamento de Ingenieria Fisica, Loma del Bosque No. 103, Col. Lomas del Campestre, 37150 Leon, Guanajuato (Mexico); Hugo R, V., E-mail: jcmartineze@ipn.mx [Universidad de Guadalajara, Centro Universitario de Tonala, Morelos No. 180, 69584 Tonala, Jalisco (Mexico)

    2015-10-15

    Full text: In the last years, the Raman spectroscopy (Rs) technique has had some applications in the study and analysis of biological samples, due to it is able to detect concentrations or presence of certain organic and inorganic compounds of medical interest. In this work, raw data were obtained through measurements in selected points on a square regions in order to detect specific organic / inorganic compounds on biological samples. Gold nano stars samples were prepared and coated with membrane markers (CD 10+ and CD 19+) and diluted in leukemic B lymphocytes. Each data block was evaluated independently by the method of principal component analysis (Pca) in order to find representative dimensionless values (Cp) for each Raman spectrum in a specific coordinate. Each Cp was normalized in a range of 0-255 in order to generate a representative image of 8 bits of the region under study. Data acquisition was performed with Raman microscopy system Renishaw in Via in the range of 550 to 1700 cm-1 with a 785 nm laser source, with a power of 17 m W and 15 s of exposure time were used for each spectrum. In preliminary results could detect the presence of molecular markers CD 10+ and CD 19+ with gold nano stars and discrimination between both markers. The results suggest conducting studies with specific concentrations organic and inorganic materials. (Author)

  3. Systematic Search of the Nearest Stars for Exoplanetary Radio Emission: Preliminary results from LOFAR

    Science.gov (United States)

    Winterhalter, Daniel; Knapp, Mary

    2016-04-01

    Radio observations have been used as a tool to search for exoplanets since before the confirmed discovery of the first extrasolar planet. To date, neither targeted observations of known exoplanets nor surveys have produced definitive detections of exoplanetary radio emission. We present the framework for, and initial results from, a blind radio survey of the nearest star systems for exoplanetary radio emission. The very closest stars were chosen to minimize the dilution of potential radio signals by distance and thereby increase the probability of a detection. The goal of this survey is to obtain, at minimum, physically meaningful upper limits on radio emission from (or modulated by) substellar companions of the nearest stars. The target selection criteria for this survey are restricted to distance, observability for LOFAR and the VLA, and data quality metrics only. Stellar properties are not considered because preconceptions about the types of systems most likely to exhibit radio emission have not been observationally confirmed and may be incorrect. Two survey targets, GJ 411 and GJ 725A/B, have been observed with the LOFAR telescope LBA (30-75 MHz) system. A series of 4 2-hour integrations and 1 3-hour integration were made for each target of a period of approximately 2 weeks. Additional observations are underway with LOFAR as well as the VLA. Preliminary results from the first LOFAR observations are presented.

  4. Holocene evolution and sedimentation rate of Alikes Lagoon, Zakynthos island, Western Greece – preliminary results

    Directory of Open Access Journals (Sweden)

    P. Avramidis

    2009-03-01

    Full Text Available In the present study we present preliminary results of Zakynthos Alikes lagoon, which is one of the most seismically active regions of Greece. In order to estimate – interpret the Holocene evolution of the area and to reconstruct the palaeonvironmental changes, we based on the data of a 21 m sediment core. Sediment types, structure, colour, as well as contact depths and bed characteristics, were recorded in the field. Standarised sedimentological analysis were carried out, on 46 samples including grain size analysis, calculation of moment measures, and micro- and molluscan fossils of 17 selected samples. Moreover, radiocarbon age determinations have been made on individual Cardium shells from two horizons and whole – core Magnetic Susceptibility (MS measurements were taken. The interpretation of depositional environments suggests a coastal environment (restricted-shallow with reduced salinity such as a lagoon margin and in a tidal flat and/or marsh particularly. The maximum age of the study sediments is about 8500 BP. The rate of sedimentation between 8280 BP and 5590 BP was 5.3 mm/yr and between 5590 BP and modern times 1.03 mm/yr. The rate of sedimentation was higher until mid-Holocene while decrease after to 1.03 mm/yr, results which are similar to other coastal areas of western Greece.

  5. A mm-Wave Polarisation Analyser Using LEKIDs: Strategy and Preliminary Numerical Results

    Science.gov (United States)

    Tartari, A.; Belier, B.; Calvo, M.; Cammilleri, V. D.; Monfardini, A.; Piat, M.; Prêle, D.; Smoot, G. F.

    2014-08-01

    The context of this study is the development of polarisation sensitive detectors in view of future Cosmic Microwave Background experiments. Our goal is to demonstrate the possibility to make a mm-wave polarisation analyser at 150 GHz using Lumped Element Kinetic Inductance Detectors (LEKIDs). Although LEKIDs are very attractive for the relative ease of fabrication, they have an intrinsic optical response which is weakly polarisation-senstive, i.e. orthogonal linear polarisations are absorbed with comparable efficiencies (with a separation typically not exceeding few dB). To overcome this difficulty, we achieve a polarised response by means of small () superconducting Nb wire-grids. Each grid is deposited on the rear side of the 300 micron Si substrate, on which 20 nm Al resonators are patterned, so that each pixel may in principle respond as an independent polarisation analyser. Simulations show encouraging results, with a deep (-20 dB) rejection of the unwanted polarisation. Although what we present here is not yet a polarimeter, this pilot study allows us to address some relevant questions that may be crucial in view of a full polarimetric architecture development. In particular, our first prototypes will allow to assess the behaviour of small grids, the interaction between adjacent polarised pixels, and to choose the most suitable resonator geometry. What we present here are preliminary design results about devices which are currently being realised, and soon ready for optical response characterisation.

  6. Experimental Impeller Fragmentation of Iliocaval Thrombosis Under Tulip Filter Protection: Preliminary Results

    International Nuclear Information System (INIS)

    Purpose: To assess the efficacy of catheter fragmentation of massive caval thrombosis and of filter protection against procedure-related pulmonary embolism. Methods: In 10 sheep, a self-expanding tulip-shaped filter made from Wallstent mesh (diameter 25 mm) was introduced from the right jugular approach into the proximal inferior vena cava. Experimentally induced massive iliocaval thrombosis was fragmented by an impeller catheter (expanded diameter 14 mm), which was advanced coaxially through the sheath of the expanded filter. Post-procedural cavography and pulmonary angiography were performed to document the extent of caval recanalization and pulmonary embolism. Results: In all cases, impeller fragmentation cleared the inferior vena cava and the iliac veins of thrombi completely. Fragments washed downstream were trapped in the filter. In two of the first cases, parts of the clots caused pulmonary embolism before the filter was in place. Further events were avoided by a modification of the experimental setup. Except for some small peripheral perfusion defects in two cases, pulmonary angiograms did not show any incidence of pulmonary embolism. Conclusion: Our preliminary results suggest that impeller fragmentation of iliocaval thrombi under tulip filter protection is effective and does not cause significant pulmonary embolism

  7. Preliminary Results from an Investigation into Nanostructured Nuclear Radiation Detectors for Non-Proliferation Applications

    Energy Technology Data Exchange (ETDEWEB)

    ,

    2012-10-01

    In recent years, the concept of embedding composite scintillators consisting of nanosized inorganic crystals in an organic matrix has been actively pursued. Nanocomposite detectors have the potential to meet many of the homeland security, non-proliferation, and border and cargo-screening needs of the nation and, by virtue of their superior nuclear identification capability over plastic, at roughly the same cost as plastic, have the potential to replace all plastic detectors. Nanocomposites clearly have the potential of being a gamma ray detection material that would be sensitive yet less expensive and easier to produce on a large scale than growing large, whole crystals of similar sensitivity. These detectors would have a broad energy range and a sufficient energy resolution to perform isotopic identification. The material can also be fabricated on an industrial scale, further reducing cost. This investigation focused on designing and fabricating prototype core/shell and quantum dot (QD) detectors. Fourteen core/shell and four QD detectors, all with the basic consistency of a mixture of nanoparticles in a polymer matrix with different densities of nanoparticles, were prepared. Nanoparticles with sizes <10 nm were fabricated, embedded in a polystyrene matrix, and the resultant scintillators’ radiation detector properties were characterized. This work also attempted to extend the gamma energy response on both low- and high-energy regimes by demonstrating the ability to detect low-energy and high-energy gamma rays. Preliminary results of this investigation are consistent with a significant response of these materials to nuclear radiation.

  8. PRELIMINARY RESULTS OF BOWL TRAPPING BEES (HYMENOPTERA, APOIDEA IN A SOUTHERN BRAZIL FOREST FRAGMENT

    Directory of Open Access Journals (Sweden)

    Rodrigo B. Gonçalves

    2013-05-01

    Full Text Available In recent years bowl traps have gained attention as a useful method for sampling bees and are now commonly used across the world for this purpose. However, specific questions about the method itself have not yet been tested on different regions of the globe. We present the preliminary results of bowl trapping in a Semidecidual Seasonal forest fragment in southern Brazil, including the test of two different color bowls, two different habitats, and the interaction of these variables in bee species number and composition. We used blue and yellow bowls in the border and in the core trails of the forest fragment. In five sampling days between October to December bowl traps captured 745 specimens of 37 morphospecies, with Halictinae bees being the richest and most abundant group. Non parametrical statistical analyses suggested that different colors of bowl traps influenced bee richness and composition and thus, they should be used together for a more complete sampling. Different trails influenced only the composition, while the interaction with different colors did not have a significant effect. These results, as well as the higher taxonomic composition of the inventoried bees, are similar to other studies reported in the literature.

  9. Preliminary Results from the PrimEx-II experiment at Jefferson Lab

    Energy Technology Data Exchange (ETDEWEB)

    Gasparian, Ashot [NCA& T, Greensboro, NC; Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2016-06-01

    Properties of the neutral pion, as the lightest hadron in Nature, are most sensitive to the basic symmetries and their partial breaking effects in the theory of the strong interaction (QCD). In particular, the po →gg decay width is primarily defined by the spontaneous chiral symmetry breaking effect (chiral anomaly) in QCD. The next order corrections to the anomaly have been shown to be small and are known to a 1% precision level. The PrimEx Collaboration at JLab has developed and performed two Primakoff type experiments to measure the po →gg decay width with a similar precision. The published result from the PrimEx-I experiment, G(p0 →gg ) = 7.82±0.14 (stat.)±0.17 (syst.) eV, was a factor of two more precise than the average value quoted in PDG-2010 [1]. The second experiment was performed in 2010 with a goal of 1.4% total uncertainty to address the next-to-leading-order theory calculations. The preliminary results from the PrimEx-II experiment are presented and discussed in this note.

  10. [A new locking nail for proximal humerus fractures: the Telegraph nail, technique and preliminary results].

    Science.gov (United States)

    Cuny, C; Pfeffer, F; Irrazi, M; Chammas, M; Empereur, F; Berrichi, A; Metais, P; Beau, P

    2002-02-01

    We present a new nail, the telegraph nail, designed for the treatment of proximal fractures of the humerus. This nail has a new locking system providing a self-stabilization of the cancelous screws inserted in small fragments. We discuss the surgical technique and present preliminary results. The anterolateral approach and nail insertion through the medial and well vascularized part of the cuff is described for simple fractures. With the cup and ball technique, this nail can also be used for complex fractures of the proximal humerus with three or four fragments and major displacement. With this method, the nail is inserted before reduction and locked in the distal humerus before fixation of the head and tuberosities around the head once the targeting device removed. We report results for the first 64 nails inserted in our unit during the first year (1998-1999). Outcome was assessed at 11 months mean follow-up using the Constant score. Outcome was favorable, including in patients with complex fractures involving 3 or 4 separate displaced fragments. Besides providing an anatomically stable reconstruction, the telegraph nail has the advantage of allowing early mobilization of the shoulder joint. This method is a useful alternative to prosthetic reconstruction for traumatic fractures of the proximal humerus. PMID:11973536

  11. Preliminary experimental results of tungsten wire-array Z-pinches on primary test stand

    International Nuclear Information System (INIS)

    The Primary Test Stand (PTS) developed at the China Academy of Engineering Physics is a 20 TW pulsed power driver, which can deliver a ∼10 MA, 70 ns rise-time (10%–90%) current to a short-circuit load and has important applications in Z-pinch driven inertial confinement fusion and high energy density physics. Preliminary results of tungsten wire-array Z-pinch experiments on PTS are presented. The load geometries investigated include 15-mm-tall cylindrical single and nested arrays with diameter ranging from 13 mm to 30 mm, consisting of 132–300 tungsten wires with 5–10 μm in diameter. Multiple diagnostics were fielded to characterize the x-ray radiation from wire-array Z pinches. The x-ray peak power (∼50 TW) and total radiated energy (∼500 kJ) were obtained from a single 20-mm-diam array with 80-ns stagnation time. The highest x-ray peak power up to 80 TW with 2.4 ns FWHM was achieved by using a nested array with 20-mm outer diameter, and the total x-ray energy from the nested array is comparable to that of single array. Implosion velocity estimated from the time-resolved image measurement exceeds 30 cm/μs. The detailed experimental results and other findings are presented and discussed

  12. Preliminary experimental results of tungsten wire-array Z-pinches on primary test stand

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Xian-Bin; Zhou, Shao-Tong; Dan, Jia-Kun; Ren, Xiao-Dong, E-mail: amosrxd@163.com; Wang, Kun-Lun; Zhang, Si-Qun; Li, Jing; Xu, Qiang; Cai, Hong-Chun; Duan, Shu-Chao; Ouyang, Kai; Chen, Guang-Hua; Ji, Ce; Wei, Bing; Feng, Shu-Ping; Wang, Meng; Xie, Wei-Ping; Deng, Jian-Jun [Key Laboratory of Pulsed Power, Institute of Fluid Physics, China Academy of Engineering Physics, P.O. Box 919-108, Mianyang, Sichuan 621999 (China); Zhou, Xiu-Wen; Yang, Yi [Research Center of Laser Fusion, China Academy of Engineering Physics, P.O. Box 919-987, Mianyang, Sichuan 621999 (China)

    2015-07-15

    The Primary Test Stand (PTS) developed at the China Academy of Engineering Physics is a 20 TW pulsed power driver, which can deliver a ∼10 MA, 70 ns rise-time (10%–90%) current to a short-circuit load and has important applications in Z-pinch driven inertial confinement fusion and high energy density physics. Preliminary results of tungsten wire-array Z-pinch experiments on PTS are presented. The load geometries investigated include 15-mm-tall cylindrical single and nested arrays with diameter ranging from 13 mm to 30 mm, consisting of 132–300 tungsten wires with 5–10 μm in diameter. Multiple diagnostics were fielded to characterize the x-ray radiation from wire-array Z pinches. The x-ray peak power (∼50 TW) and total radiated energy (∼500 kJ) were obtained from a single 20-mm-diam array with 80-ns stagnation time. The highest x-ray peak power up to 80 TW with 2.4 ns FWHM was achieved by using a nested array with 20-mm outer diameter, and the total x-ray energy from the nested array is comparable to that of single array. Implosion velocity estimated from the time-resolved image measurement exceeds 30 cm/μs. The detailed experimental results and other findings are presented and discussed.

  13. Palliation of Postoperative Gastrointestinal Anastomotic Malignant Strictures with Flexible Covered Metallic Stents: Preliminary Results

    International Nuclear Information System (INIS)

    Purpose: To evaluate the efficacy of the placement of covered metallic stents for palliation of gastrointestinal anastomotic strictures secondary to recurrent gastric cancer.Methods: Under fluoroscopic guidance, placement of one or two self-expandable covered metallic stents was attempted perorally in 11 patents (aged 48-76 years) with anastomotic stenoses due to recurrent gastric malignancies. The strictures involved both the afferent and efferent loops in three patients. All patients had poor peroral food intake with severe nausea and vomiting after ingestion. The technical and clinical success was evaluated.Results: Placement of the covered stent was technically successful in 13 of 15 (87%) attempts in ten patients. After the procedure, 9 of 11 (82%) patients overall were able to ingest at least a liquid diet and had markedly decreased incidence of vomiting. During the follow-up of 2-31 weeks (mean 8.5 weeks) there were no major complications.Conclusion: These preliminary results suggest that flexible, covered stents may provide effective palliation of malignant anastomotic stricture secondary to recurrent gastric cancer

  14. Low-dose helical chest CT in asbestos exposed workers in the Veneto Region: preliminary results

    International Nuclear Information System (INIS)

    Purpose. To evaluate the preliminary results of low-dose helical chest CT in a group of individuals with an occupational exposure to asbestos. Materials and methods. Between October 2000 and May 2004, 1512 asymptomatic subjects, selected by Occupational Health physicians of the Veneto Region among those with a significant exposure to asbestos, underwent low-dose helical chest CT without contrast media administration. According to their features, all pulmonary nodules identified underwent pathology, further CT evaluation or follow-up with low-dose CT. Results. Apart tram benign pleural findings (in 40% of subjects), 590 pulmonary nodules were identified. Eleven nodules underwent pathologic examination, which detected 5 malignant lesions, and 51 were evaluated with other CT techniques, in all cases demonstrating benign features. In followup low-dose CT scans, performed in the remaining 528 nodules, a minimal increase in size occurred in 4 cases only. Conclusions. Screening for clinically relevant pulmonary lesions in asymptomatic people with occupational exposure to asbestos may be useful if rigorous enrolment criteria are adopted. The management of abnormal findings is cost-effective if it is based on the morphological features of each finding

  15. Simplified benchmark based on 2670 ISTC WWER post-irradiation examinations - specification and preliminary results

    International Nuclear Information System (INIS)

    Experimental validation of depletion computer codes is an ongoing need in spent fuel management. In WWER application area the lack of well-documented experimental data concerning depleted fuel is serious, being an obstacle to introduce new effective technologies and approaches in spent fuel management, e.g. burnup credit (BUC). In 2004, the final report of ISTC 2670 project on post-irradiation examinations (PIE) of eight samples from Novovoronezh-4 NPP (specimens taken from one assembly covering burnup range from 22 to 45 MWd/kgU) was released and published. The 2670 WWER-440 post-irradiation is the first publicly available measurement providing also fission product concentrations for the 'BUC set' of isotopes. Although the documentation of the experiment was quite comprehensive, still there were missing some important data needed for a precise depletion simulation. Therefore in 2006, NRI in collaboration with RIAR Dimitrovgrad, where the measurements were carried out, gathered the missing data and prepared a well-specified simplified benchmark, based on this measurement. Its specification as well as results of preliminary calculations using several depletion codes are presented in this paper. Final evaluation of the results calculated by all benchmark participants is expected for presentation in 2008 (Authors)

  16. Biological image construction by using Raman radiation and Pca: preliminary results

    International Nuclear Information System (INIS)

    Full text: In the last years, the Raman spectroscopy (Rs) technique has had some applications in the study and analysis of biological samples, due to it is able to detect concentrations or presence of certain organic and inorganic compounds of medical interest. In this work, raw data were obtained through measurements in selected points on a square regions in order to detect specific organic / inorganic compounds on biological samples. Gold nano stars samples were prepared and coated with membrane markers (CD 10+ and CD 19+) and diluted in leukemic B lymphocytes. Each data block was evaluated independently by the method of principal component analysis (Pca) in order to find representative dimensionless values (Cp) for each Raman spectrum in a specific coordinate. Each Cp was normalized in a range of 0-255 in order to generate a representative image of 8 bits of the region under study. Data acquisition was performed with Raman microscopy system Renishaw in Via in the range of 550 to 1700 cm-1 with a 785 nm laser source, with a power of 17 m W and 15 s of exposure time were used for each spectrum. In preliminary results could detect the presence of molecular markers CD 10+ and CD 19+ with gold nano stars and discrimination between both markers. The results suggest conducting studies with specific concentrations organic and inorganic materials. (Author)

  17. Simultaneous chemoradiotherapy with Taxol/Carboplatin in advanced head and neck cancer. Preliminary results

    International Nuclear Information System (INIS)

    Background: The purpose of simultaneous chemoradiotherapy is to increase local-regional control and to decrease the incidence of distant metastases. Regimens containing cisplatin/5-FU chemotherapy are widely accepted as standard treatment in advanced head and neck cancer. Most studies reported promising response and survival data, but also severe mucosal toxicity. In recent years the newly developed drug Taxol demonstrated interesting activity in head and neck cancer as a single agent and as well in combination drug regimens. In the present outpatient phase-II trial we investigated the combination of Taxol/carboplatin with 40 Gy radiotherapy in a neoadjuvant setting of operable Stage-III/IV squamous cell carcinoma of the oral cavity and oropharynx. Patients and Methods: Twelve patients were enrolled in this ongoing trial with a projected number of 30 patients and received 5 cycles of weekly Taxol (40 mg/m2) and carboplatin (AUC 1.5) with conventional radiotherapy (40 Gy). Within 3 to 4 weeks after chemoradiotherapy resection of the primary tumor and the regional neck nodes was performed. Results: So far 12 patients were evaluable for toxicity and response. Complete response was noted in 8/12 patients (Cr 66%). In 6/10 patients (60%) complete pathologic response was documented in the resection specimens. Conclusion: Our preliminary results demonstrated excellent clinical and pathological response rates of concurrent Taxol/carboplatin and radiotherapy as preoperative treatment modality in advanced oral and oropharyngeal cancer. (orig.)

  18. A Morphing Technique Applied to Lung Motions in Radiotherapy: Preliminary Results

    Directory of Open Access Journals (Sweden)

    R. Laurent

    2010-01-01

    Full Text Available Organ motion leads to dosimetric uncertainties during a patient’s treatment. Much work has been done to quantify the dosimetric effects of lung movement during radiation treatment. There is a particular need for a good description and prediction of organ motion. To describe lung motion more precisely, we have examined the possibility of using a computer technique: a morphing algorithm. Morphing is an iterative method which consists of blending one image into another image. To evaluate the use of morphing, Four Dimensions Computed Tomography (4DCT acquisition of a patient was performed. The lungs were automatically segmented for different phases, and morphing was performed using the end-inspiration and the end-expiration phase scans only. Intermediate morphing files were compared with 4DCT intermediate images. The results showed good agreement between morphing images and 4DCT images: fewer than 2 % of the 512 by 256 voxels were wrongly classified as belonging/not belonging to a lung section. This paper presents preliminary results, and our morphing algorithm needs improvement. We can infer that morphing offers considerable advantages in terms of radiation protection of the patient during the diagnosis phase, handling of artifacts, definition of organ contours and description of organ motion.

  19. Postal auditing methodology used to find out the performance of high rate brachytherapy equipment

    International Nuclear Information System (INIS)

    This work describes results from a methodology implemented at the Secondary Laboratory for Dosimetric Calibration at CPHR used to check the brachytherapy performance at high doses rate using Cesium 137 or cobalt 60 sources

  20. Calibration of brachytherapy sources. Guidelines on standardized procedures for the calibration of brachytherapy sources at Secondary Standard Dosimetry Laboratories (SSDLs) and hospitals

    International Nuclear Information System (INIS)

    Today, irradiation by brachytherapy is considered an essential part of the treatment for almost all the sites of cancer. With the improved localization techniques and treatment planning systems, it is now possible to have precise and reproducible dose delivery. However, the desired clinical results can only be achieved with a good clinical and dosimetric practice, i.e. with the implementation of a comprehensive quality assurance (QA) programme which includes detailed quality control procedures. As summarized in the present report, accidents in brachytherapy treatments have been caused due to the lack of traceable calibration of the sources, due to the incorrect use of quantities and units, or errors made in the dose calculation procedure. The International Basic Safety Standards for Protection against Ionizing Radiation and for the Safety of Radiation Sources has established a requirement on the calibration of sources used for medical exposure. For sources used in brachytherapy treatments, a calibration traceable to a standards dosimetry laboratory is required. The present report deals with the calibration of brachytherapy sources and related quality control (QC) measurements, QC of ionization chambers and safety aspects related to the calibration procedures. It does not include safety aspects related to the clinical use of brachytherapy sources, which have been addressed in a recent IAEA publication, IAEA-TECDOC-1040, 'Design and Implementation of a Radiotherapy Programme: Clinical, Medical Physics, Radiation Protection and Safety Aspects'. The procedures recommended in this report yield traceability to internationally accepted standards. It must be realized, however, that a comprehensive QA programme for brachytherapy cannot rest on source calibration alone, but must ensure QC of all the equipment and techniques that are used for the dose delivery to the patient. The present publication incorporates the reports of several consultants meetings in the field of