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Sample records for brachytherapy preliminary results

  1. Ruthenium-106 brachytherapy for uveal melanomas. Preliminary results: a single institutional experience; Braquiterapia com rutenio-106 em melanomas uveais. Resultados preliminares: experiencia uni-instuticional

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    Dias, Rodrigo Souza; Giordani, Adelmo Jose; Segreto, Helena Regina Comodo; Segreto, Roberto Araujo [Universidade Federal de Sao Paulo/Escola Paulista de Medicina (Unifesp/EPM), Sao Paulo, SP (Brazil). Departamento de Medicina. Setor de Radioterapia ; Erwenne, Clelia Maria; Teixeira, Luiz Fernando [Universidade Federal de Sao Paulo/Escola Paulista de Medicina (UNIFESP/EPM), Sao Paulo, SP (Brazil). Dept. de Oftalmologia]. E-mail: segreto. dmed@epm.br

    2007-03-15

    Objective: To analyze the early response of uveal melanomas in patients treated with ruthenium-106 brachytherapy. Materials And Methods: In the period between April 2002 and July 2003, 20 patients diagnosed with uveal melanoma were submitted to ruthenium-106 brachytherapy. The calculated dose delivered at the apex of the tumor ranged between 55 Gy and 100 Gy. Patients with lesions greater than 5 mm were submitted to transpupillary thermotherapy concomitantly with ophthalmic plaque insertion. Results: As regards the lesions site, 75% of the lesions were located in the choroid, 15% in the iris, and the remainder 10% in the ciliary body. In a median 19-month-follow-up, the progression-free survival for brachytherapy was 69%, and 87% for associated brachytherapy and transpupillary thermotherapy. A significant tumor height reduction was observed after treatment. No patient was submitted to enucleation. Conclusion: Our preliminary results show that ruthenium-106 brachytherapy is an appropriate method for conservative treatment of patients with uveal melanomas in terms of local management, ocular and visual acuity preservation with an acceptable complications incidence rate. (author)

  2. Stereotactic body radiation therapy via helical tomotherapy to replace brachytherapy for brachytherapy-unsuitable cervical cancer patients – a preliminary result

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    Hsieh CH

    2013-02-01

    Full Text Available Chen-Hsi Hsieh,1–3 Hui-Ju Tien,1 Sheng-Mou Hsiao,4 Ming-Chow Wei,4 Wen-Yih Wu,4 Hsu-Dong Sun,4 Li-Ying Wang,5 Yen-Ping Hsieh,6 Yu-Jen Chen,3,7–9 Pei-Wei Shueng1,101Department of Radiation Oncology, Far Eastern Memorial Hospital, Taipei, Taiwan; 2Department of Medicine, 3Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; 4Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Taipei, Taiwan; 5School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan; 6Department of Senior Citizen Service Management, National Taichung University of Science and Technology, Taichung, Taiwan; 7Department of Radiation Oncology, 8Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan; 9Graduate Institute of Sport Coaching Science, Chinese Culture University, Taipei, Taiwan; 10Department of Radiation Oncology, National Defense Medical Center, Taipei, TaiwanAim: To review the experience and to evaluate the results of stereotactic body radiation therapy (SBRT via helical tomotherapy (HT, for the treatment of brachytherapy-unsuitable cervical cancer.Methods: Between September 1, 2008 to January 31, 2012, nine cervical cancer patients unsuitable for brachytherapy were enrolled. All of the patients received definitive whole pelvic radiotherapy with or without chemotherapy, followed by SBRT via HT.Results: The actuarial locoregional control rate at 3 years was 78%. The mean biological equivalent dose in 2-Gy fractions of the tumor, rectum, bladder, and intestines was 76.0 ± 7.3, 73.8 ± 13.2, 70.5 ± 10.0, and 43.1 ± 7.1, respectively. Only two had residual tumors after treatment, and the others were tumor-free. Two patients experienced grade 3 acute toxicity: one had diarrhea; and another experienced thrombocytopenia. There were no grade 3 or 4 subacute toxicities. Three patients suffered from manageable rectal bleeding in

  3. Phase II Trial of Combined High Dose Rate Brachytherapy and External Beam Radiotherapy for Adenocarcinoma of the Prostate: Preliminary Results of RTOG 0321

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    Hsu, I-Chow; Bae, Kyounghwa; Shinohara, Katsuto; Pouliot, Jean; Purdy, James; Ibbott, Geoffrey; Speight, Joycelyn; Vigneault, Eric; Ivker, Robert; Sandler, Howard

    2010-01-01

    Purpose To estimate the rate of late grade 3 or greater genitourinary (GU) and gastrointestinal (GI) adverse events (AEs) following treatment with external beam radiation therapy and prostate high dose rate (HDR) brachytherapy. Methods and Materials Each participating institution submitted CT based HDR brachytherapy dosimetry data electronically for credentialing and for each study patient. Patients with locally confined T1c-T3b prostate cancer were eligible for this study. All patients were treated with 45 Gy in 25 fractions from external beam radiotherapy and one HDR implant delivering 19 Gy in 2 fractions. All AEs were graded according to CTCAEv3.0. Late GU/ GI AEs were defined as those occurring more than nine months from the start of the protocol treatment, in patients with at least 18 months of potential follow-up. Results A total of 129 patients from 14 institutions were enrolled in this study. 125 patients were eligible and AE data was available for 112 patients. The pretreatment characteristics of the patients were as follows: T1c-T2c 91%, T3a-T3b 9%, PSA ≤ 10 70%, PSA >10-≤20 30%, GS 2-6 10%, GS 7 72%, and GS 8-10 18%. At a median follow-up time of 29.6 months, 3 acute and 4 late grade 3 GU/GI AEs were reported. The estimated rate of late grade 3-5 GU and GI AE at 18 months was 2.56%. Conclusion This is the first prospective, multi-institutional trial of CT based HDR brachytherapy and external beam radiotherapy. The technique and doses used in this study resulted in acceptable levels of adverse events. PMID:20207506

  4. Braquiterapia com rutênio-106 em melanomas uveais - resultados preliminares: experiência uni-institucional Ruthenium-106 brachytherapy for uveal melanomas - preliminary results: a single institutional experience

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    Rodrigo Souza Dias

    2007-04-01

    associated brachytherapy and transpupillary thermotherapy. A significant tumor height reduction was observed after treatment. No patient was submitted to enucleation. CONCLUSION: Our preliminary results show that ruthenium-106 brachytherapy is an appropriate method for conservative treatment of patients with uveal melanomas in terms of local management, ocular and visual acuity preservation with an acceptable complications incidence rate.

  5. esophageal cancer: preliminary results

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    Afsaneh Maddah Safaei

    2017-01-01

    Full Text Available Purpose: Dysphagia is a common initial presentation in locally advanced esophageal cancer and negatively impacts patient quality of life and treatment compliance. To induce fast relief of dysphagia in patients with potentially operable esophageal cancer high-dose-rate (HDR brachytherapy was applied prior to definitive radiochemotherapy. Material and methods : In this single arm phase II clinical trial between 2013 to 2014 twenty patients with locally advanced esophageal cancer (17 squamous cell and 3 adenocarcinoma were treated with upfront 10 Gy HDR brachytherapy, followed by 50.4 Gy external beam radiotherapy (EBRT and concurrent chemotherapy with cisplatin/5-fluorouracil. Results : Tumor response, as measured by endoscopy and/or computed tomography scan, revealed complete remission in 16 and partial response in 4 patients (overall response rate 100%. Improvement of dysphagia was induced by brachytherapy within a few days and maintained up to the end of treatment in 80% of patients. No differences in either response rate or dysphagia resolution were found between squamous cell and adenocarcinoma histology. The grade 2 and 3 acute pancytopenia or bicytopenia reported in 4 patients, while sub-acute adverse effects with painful ulceration was seen in five patients, occurring after a median of 2 months. A perforation developed in one patient during the procedure of brachytherapy that resolved successfully with immediate surgery. Conclusions : Brachytherapy before EBRT was a safe and effective procedure to induce rapid and durable relief from dysphagia, especially when combined with EBRT.

  6. The Preliminary Prototype of Medium Dose Rate Brachytherapy Equipment

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    A. Satmoko

    2013-08-01

    Full Text Available A preliminary prototype of a brachytherapy equipment has been constructed. The work started by developing conceptual design, followed by basic design and detailed design. In the conceptual design, design requirements are stated. In the basic design, technical specifications for main components are determined. In detailed design, general drawings are discussed. The prototype consists of three main systems: a mechanical system, an instrumentation system, and a safety system. The mechanical system assures the movement mechanism of the isotope source position beginning from the standby position until the applicators. It consists of three main modules: a position handling module, a container module, and a channel distribution module. The position handling module serves to move the isotope source position. As shielding, the second module is to store the source when the equipment is in standby position. The prototype provides 12 output channels. The channel selection is performed by the third module. The instrumentation system controls the movement of source position by handling motor operations. It consists of several modules. A microcontroller module serves as a control center whose task includes both controlling motors and communicating with computer. A motor module serves to handle motors. 10 sensors, including their signal conditionings, are introduced to read the environment conditions of the equipment. LEDs are used to display these conditions. In order to facilitate the operators’ duty, communication via RS232 is provided. The brachytherapy equipment can therefore be operated by using computer. Interface software is developed using C# language. To complete both mechanical and instrumentation systems performance, a safety system is developed to make sure that the safety for operator and patients from receiving excessive radiation. An interlock system is introduced to guard against abnormal conditions. In the worst case, a manual intervention

  7. Two years results of electronic brachytherapy for basal cell carcinoma

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    Rosa Ballester-Sánchez

    2017-06-01

    Full Text Available Purpose: The use of radiation therapy (RT for non-melanoma skin cancer (NMSC has been changing throughout the last century. Over the last decades, the use of radiotherapy has surged with the development of new techniques, applicators, and devices. In recent years, electronic brachytherapy (eBT devices that use small x-ray sources have been introduced as alternative to radionuclide dependence. Nowadays, several devices have been incorporated, with a few series reported, and with a short follow-up, due to the recent introduction of these systems. The purpose of this work is to describe the clinical results of our series after two years follow-up with a specific eBT system. Material and methods: This is a prospective single-center, non-randomized pilot study, to assess clinical results of electronic brachytherapy in basal cell carcinoma using the Esteya® system. In 2014, 40 patients with 60 lesions were treated. Patient follow-up on a regular basis was performed for a period of two years. Results: Twenty-six patients with 44 lesions achieved two years follow-up. A complete response was documented in 95.5% of cases. Toxicity was mild (G1 or G2 in all cases, caused by erythema, erosion, or alopecia. Cosmesis was excellent in 88.6% of cases, and good in the rest. Change in pigmentation was the most frequent cosmetic alteration. Conclusions : This work is special, since the equipment’s treatment voltage was 69.5 kV, and this is the first prospective study with long term follow-up with Esteya®. These preliminary report show excellent results with less toxicity and excellent cosmesis. While surgery has been the treatment of choice, certain patients might benefit from eBT treatment. These are elderly patients with comorbidities or undergoing anticoagulant treatment as well as those who simply refuse surgery or might have other contraindications.

  8. Brachytherapy in Lip Carcinoma: Long-Term Results

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    Guibert, Mireille, E-mail: mireilleguib@voila.fr [Department of Head and Neck Surgery, Larrey Hospital, Toulouse (France); David, Isabelle [Department of Radiation Oncology, Claudius Regaud Institut, Toulouse (France); Vergez, Sebastien [Department of Head and Neck Surgery, Larrey Hospital, Toulouse (France); Rives, Michel [Department of Radiation Oncology, Claudius Regaud Institut, Toulouse (France); Filleron, Thomas [Department of Epidemiology, Claudius Regaud Institut, Toulouse (France); Bonnet, Jacques; Delannes, Martine [Department of Radiation Oncology, Claudius Regaud Institut, Toulouse (France)

    2011-12-01

    Purpose: The aim of this study was to evaluate the effectiveness of low-dose-rate brachytherapy for local control and relapse-free survival in squamous cell and basal cell carcinomas of the lips. We compared two groups: one with tumors on the skin and the other with tumors on the lip. Patients and methods: All patients had been treated at Claudius Regaud Cancer Centre from 1990 to 2008 for squamous cell or basal cell carcinoma. Low-dose-rate brachytherapy was performed with iridium 192 wires according to the Paris system rules. On average, the dose delivered was 65 Gy. Results: 172 consecutive patients were included in our study; 69 had skin carcinoma (squamous cell or basal cell), and 92 had squamous cell mucosal carcinoma. The average follow-up time was 5.4 years. In the skin cancer group, there were five local recurrences and one lymph node recurrence. In the mucosal cancer group, there were ten local recurrences and five lymph node recurrences. The 8-year relapse-free survival for the entire population was 80%. The 8-year relapse-free survival was 85% for skin carcinoma 75% for mucosal carcinoma, with no significant difference between groups. The functional results were satisfactory for 99% of patients, and the cosmetic results were satisfactory for 92%. Maximal toxicity observed was Grade 2. Conclusions: Low-dose-rate brachytherapy can be used to treat lip carcinomas at Stages T1 and T2 as the only treatment with excellent results for local control and relapse-free survival. The benefits of brachytherapy are also cosmetic and functional, with 91% of patients having no side effects.

  9. [Basic principles and results of brachytherapy in gynecological oncology].

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    Kanaev, S V; Turkevich, V G; Baranov, S B; Savel'eva, V V

    2014-01-01

    The fundamental basics of contact radiation therapy (brachytherapy) for gynecological cancer are presented. During brachytherapy the principles of conformal radiotherapy should be implemented, the aim of which is to sum the maximum possible dose of radiation to the tumor and decrease the dose load in adjacent organs and tissues, which allows reducing the frequency of radiation damage at treatment of primary tumors. It is really feasible only on modern technological level, thanks to precision topometry preparation, optimal computer dosimetrical and radiobiological planning of each session and radiotherapy in general. Successful local and long-term results of the contact radiation therapy for cancer of cervix and endometrium are due to optimal anatomical and topometrical ratio of the tumor localization, radioactive sources, and also physical and radiobiological laws of distribution and effects of ionizing radiation, the dose load accounting rules.

  10. LOW-DOSE RATE BRACHYTHERAPY FOR PROSTATE CANCER: DIFFERENT INDICATIONS – DIFFERENT RESULTS

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    V. A. Biryukov

    2014-07-01

    Full Text Available In Russia, there is presently a growing interest in low-dose intratissue radiotherapy (brachytherapy for locally advanced prostate cancer (PC. Since its inception, current brachytherapy has undergone a number of significant changes in terms of improved visualization and better treatment planning and monitoring, which is sure to have affected the higher quality of their performance and better long-term results. The main purpose of the given paper is to generalize the data of foreign investigators who have the greatest experience with brachytherapy for its further use in the treatment of patients with locally advanced PC under the conditions of Russian clinics.

  11. Long term results of PDR brachytherapy for lip cancer

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    Lennart Hardell

    2011-07-01

    Full Text Available Purpose: To evaluate the long time outcome with regard to local tumour control and side effects of a pulsed dose rate (PDR monobrachytherapy of primary or recurrent cancer of the lip. Material and methods: Between 1995 and 2007 we treated 43 patients with primary or recurrent clinical T1-T3N0 lip cancers. There were 22 T1 patients (51%, 16 T2 (37% and 5 T3 cases (12%. A median dose of 60 (55-66 Gy was given, depending on the tumour volume. The PDR treatment was delivered with 0.83 Gy/pulse every second hour for 5.5-6.5 days. The patients were followed for a median of 55 (1-158 months. Results: The 2-, 5- and 10-year rates of actuarial local control were 97.6%, 94.5% and 94.5%, overall survival 88.0%, 58.9% and 39.1%, disease free survival 92.7%, 86.4% and 86.4% respectively. The regional control rate was 93%. One patient (2% developed distant metastases. A dosimetrical analysis showed a mean treated volume of 14.9 (3.0-56.2 cm3. Long-term side effects were mild and the cosmetic outcome excellent, except for 1 case (2% of soft tissue necrosis and 1 case (2% of osteoradionecrosis. Conclusions: Local outcome is excellent and similar to other published studies of continuous low dose rate (cLDR brachytherapy.

  12. Favorable Preliminary Outcomes for Men With Low- and Intermediate-risk Prostate Cancer Treated With 19-Gy Single-fraction High-dose-rate Brachytherapy

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    Krauss, Daniel J., E-mail: dkrauss@beaumont.edu [Oakland University William Beaumont School of Medicine, Royal Oak, Michigan (United States); Ye, Hong [Oakland University William Beaumont School of Medicine, Royal Oak, Michigan (United States); Martinez, Alvaro A. [21st Century Oncology, Farmington Hills, Michigan (United States); Mitchell, Beth; Sebastian, Evelyn; Limbacher, Amy; Gustafson, Gary S. [Oakland University William Beaumont School of Medicine, Royal Oak, Michigan (United States)

    2017-01-01

    Purpose: To report the toxicity and preliminary clinical outcomes of a prospective trial evaluating 19-Gy, single-fraction high-dose-rate (HDR) brachytherapy for men with low- and intermediate-risk prostate cancer. Methods and Materials: A total of 63 patients were treated according to an institutional review board-approved prospective study of single-fraction HDR brachytherapy. Eligible patients had tumor stage ≤T2a, prostate-specific antigen level ≤15 ng/mL, and Gleason score ≤7. Patients with a prostate gland volume >50 cm{sup 3} and baseline American Urologic Association symptom score >12 were ineligible. Patients underwent transrectal ultrasound-guided transperineal implantation of the prostate, followed by single-fraction HDR brachytherapy. Treatment was delivered using {sup 192}Ir to a dose of 19 Gy prescribed to the prostate, with no additional margin applied. Results: Of the 63 patients, 58 had data available for analysis. Five patients had withdrawn consent during the follow-up period. The median follow-up period was 2.9 years (range 0.3-5.2). The median age was 61.4 years. The median gland volume at treatment was 34.8 cm{sup 3}. Of the 58 patients, 91% had T1 disease, 71% had Gleason score ≤6 (29% with Gleason score 7), and the median pretreatment prostate-specific antigen level was 5.1 ng/mL. The acute and chronic grade 2 genitourinary toxicity incidence was 12.1% and 10.3%, respectively. No grade 3 urinary toxicity occurred. No patients experienced acute rectal toxicity grade ≥2, and 2 experienced grade ≥2 chronic gastrointestinal toxicity. Three patients experienced biochemical failure, yielding a 3-year cumulative incidence estimate of 6.8%. Conclusions: Single-fraction HDR brachytherapy is well-tolerated, with favorable preliminary biochemical and clinical disease control rates.

  13. High-dose-rate brachytherapy for uterine cervical cancer: the results of different fractionation regimen

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    Yoon, Won Sup; Kim, Tae Hyun; Yang, Dae Sik; Choi, Myung Sun; Kim, Chul Yong [College of Medicine, Korea University, Seoul (Korea, Republic of)

    2002-09-15

    Although high-dose-rate (HDR) brachytherapy regimens have been practiced with a variety of modalities and various degrees of success, few studies on the subject have been conducted. The purpose of this study was to compare the results of local control and late complication rate according to different HDR brachytherapy fractionation regimens in uterine cervical cancer patients. From November 1992 to March 1998, 224 patients with uterine cervical cancer were treated with external beam irradiation and HDR brachytherapy. In external pelvic radiation therapy, the radiation dose was 45 {approx} 54 Gy (median dose 54 Gy) with daily fraction size 1.8 Gy, five times per week. In HDR brachytherapy, 122 patients (Group A) were treated with three times weekly with 3 Gy to line-A (isodose line of 2 cm radius from source) and 102 patients (Group B) underwent the HDR brachytherapy twice weekly with 4 or 4.5 Gy to line-A after external beam irradiation. Iridium-192 was used as the source of HDR brachytherapy. Late complication was assessed from grade 1 to 5 using the RTOG morbidity grading system. The local control rate (LCR) at 5 years was 80% in group A and 84% in group B ({rho} = 0.4523). In the patients treated with radiation therapy alone, LCR at 5 years was 60.9% in group A and 76.9% in group B ({rho} = 0.2557). In post-operative radiation therapy patients, LCR at 5 years was 92.6% in group A and 91.6% in group B ({rho} 0.8867). The incidence of late complication was 18% (22 patients) and 29.4% (30 patients), of bladder complication was 9.8% (12 patients) and 14.7% (15 patients), and of rectal complication was 9.8% (12 patients) and 21.6% (22 patients), in group A and B, respectively. Lower fraction sized HDR brachytherapy was associated with decrease in late complication ({rho} =0.0405) (rectal complication, {rho} = 0.0147; bladder complication, {rho} =0.115). The same result was observed in postoperative radiation therapy patients ({rho} = 0.0860) and radiation only

  14. Palliative interstitial HDR brachytherapy for recurrent rectal cancer. Implantation techniques and results

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    Kolotas, C. [Dept. of Radiation Oncology, Offenbach Hospital, Offenbach (Germany); Dept. of Radio-Oncology, Univ. of Bern, Inselspital, Bern (Switzerland); Roeddiger, S.; Martin, T.; Tselis, N.; Baltas, D.; Zamboglou, N. [Dept. of Radiation Oncology, Offenbach Hospital, Offenbach (Germany); Strassmann, G. [Dept. of Radiotherapy, Univ. Hospital, Philipps Univ., Marburg (Germany); Aebersold, D.M. [Dept. of Radio-Oncology, Univ. of Bern, Inselspital, Bern (Switzerland)

    2003-07-01

    Purpose: To report the methods and clinical results of CT-based interstitial high-dose-rate (HDR) brachytherapy procedures for the palliative treatment of recurrent rectal cancer. Patients and Methods: A total of 44 brachytherapy implants were performed in 38 patients. CT-guided catheter implants were performed in 34 patients under local anesthesia and sedation, and four patients were implanted intraoperatively. Of 40 CT-guided implants, 20 were done using metallic needles introduced via the sacrum and 20 were transperineal implants of plastic tubes in the presacral region. Postimplant CT scans were used for three-dimensional (3-D) conformal brachytherapy planning. Patients implanted with metallic needles were given a single fraction of 10-15 Gy using HDR {sup 192}Ir, and those who received transperineal implants of plastic catheters were given fractionated brachytherapy, 5 Gy twice daily to a total dose of 30-40 Gy. The median tumor volume was 225 cm{sup 3} with a range of 41-2,103 cm{sup 3}. Results: After a median follow-up of 23.4 months, a total of 13/38 patients were alive. The median postbrachytherapy survival was 15 months with 18 of the 25 deaths due to distant metastases. Tumor response was as follows: 6/38 partial remission, 28/38 stable disease, and 4/38 local progression. A planning target volume (PTV) coverage > 85% was achieved in 42/44 implants. The treatment was well tolerated, and no acute complications were observed. One patient developed a fistula after 8 months. Pain relief was recorded in 34 patients (89.5%), and the median duration of this palliative effect was 5 months with a range of 1-13 months. Conclusions: Interstitial HDR brachytherapy is a valuable tool for the delivery of high doses and achieves effective palliation in recurrent rectal carcinoma. (orig.)

  15. Techniques and results of brachytherapy for carcinoma of the tongue

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    Jingu, Kenichi; Akita, Yuzou [Fukuoka Univ. (Japan). School of Medicine; Shimamura, Yasushi; Kunitake, Naonobu; Nakamura, Kazumasa; Oomagari, Junichi; Wada, Susumu; Uehara, Satoru; Masuda, Kouji

    1997-11-01

    Three hundred and twelve patients with 1987 UICC T1, 2 carcinoma of the tongue, who underwent definitive brachytherapy from November, 1978 to March, 1991 in the Department of Radiology, Kyushu University Hospital, and from January, 1985 to December, 1994 in the Department of Radiotherapy, Kyushu Cancer Center, were reviewed retrospectively. All patients were admitted 15-30 mg Pentazocine and O.25 mg Atropine sulfate as the premedication. Thirty to 60 minutes after, the tip of tongue and the lesion were put under local infiltration anesthesia with 10-20 ml of 1-2% Lidocaine or 1% Procaine HCL. The tongue was pulled out by the thread of the tip. Partial resection or wide excisional biopsy of the tumor was performed to reduce the tumor volume and the radiation volume and also to estimate Jacobson-Yamamoto`s grading histologically in the bottom of the tumor. Radium needles or Iridium hair pins were implanted in the lesion following Paterson`s method, and left for 3-10 days to the minimum tumor dose of 70 Gy calculated by computer. The secondary neck lymph node metastases rates of the patients with T1 carcinoma of the tongue were 27% and 53% in the Jacobson-Yamamoto grading 1-3 group and 4 group. The rates of the patients with T2 were 28% and 82% in 1-3 group and 4 group. Two year`s local control rates of the patients with T1 and T2 carcinoma were 95% and 82%. Two year`s late reaction (mandibular bone exposure or refractory ulcer of soft tissue) rates of the patients with T1 and T2 carcinoma were 7% and 12%. (author)

  16. Preliminary results of UCN τ

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    Pattie, Robert; UCNtau Collaboration

    2017-01-01

    There is currently a 4 σ discrepancy between measurements of the neutron lifetime performed using cold neutron beams and those performed with ultracold neutron (UCN) storage vessels. The UCN τ experiment uses an asymmetric magneto-gravitational UCN trap with in situ counting of surviving neutrons to measure the neutron lifetime. This design eliminates a major systematic of previous bottle experiments related to the loss of UCN on material trap walls and with unloading neutrons from the storage vessel. A new in situ detection system was used in the 2015-2016 run that was able to measure the population of surviving UCN at different heights in the trap, providing important information on spectral evolution. Understanding the behavior of quasi-bound UCN in a bottle experiment is essential to achieving a subsecond precision measurement of τn. We will present the preliminary results from the 2015-2016 data set and an update on the UCN τ experiment.

  17. EUPORIAS: plans and preliminary results

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    Buontempo, C.

    2013-12-01

    Recent advances in our understanding and ability to forecast climate variability have meant that skilful predictions are beginning to be routinely made on seasonal to decadal (s2d) timescales. Such forecasts have the potential to be of great value to a wide range of decision-making, where outcomes are strongly influenced by variations in the climate. In 2012 the European Commission funded EUPORIAS, a four year long project to develop prototype end-to-end climate impact prediction services operating on a seasonal to decadal timescale, and assess their value in informing decision-making. EUPORIAS commenced on 1 November 2012, coordinated by the UK Met Office leading a consortium of 24 organisations representing world-class European climate research and climate service centres, expertise in impacts assessments and seasonal predictions, two United Nations agencies, specialists in new media, and commercial companies in climate-vulnerable sectors such as energy, water and tourism. The poster describes the setup of the project, its main outcome and some of the very preliminary results.

  18. Effect of implanted brachytherapy seeds on optical fluence distribution: preliminary ex vivo study

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    Hetzel, Fred W.; Chen, Qun; Ding, Meisong; Newman, Francis; Dole, Kenneth C.; Huang, Zheng; Blanc, Dominique

    2007-02-01

    Photodynamic therapy (PDT) has gradually found its place in the treatment of malignant and non-malignant human diseases. Currently, interstitial PDT is being explored as an alternative modality for newly diagnosed and recurrent organ-confined prostate cancer. The interstitial PDT for the treatment of prostate cancer might be considered to treat prostates with permanent radioactive seeds implantation. However, the effect of implanted brachytherapy seeds on the optical fluence distribution of PDT light has not been studied before. This study investigated, for the first time, the effect of brachytherapy seed on the optical fluence distribution of 760 nm light in ex vivo models (meat and canine prostate).

  19. A multi-institutional study of feasibility, implementation, and early clinical results with noninvasive breast brachytherapy for tumor bed boost.

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    Hamid, Subarna; Rocchio, Kathy; Arthur, Douglas; Vera, Robyn; Sha, Sandra; Jolly, Michele; Cavanaugh, Sean; Wooten, Eric; Benda, Rashmi; Greenfield, Brad; Prestidge, Bradley; Ackerman, Scot; Kuske, Robert; Quiet, Coral; Snyder, Margaret; Wazer, David E

    2012-08-01

    To evaluate the feasibility, implementation, and early results of noninvasive breast brachytherapy (NIBB) for tumor bed boost with whole breast radiation therapy (WBRT). NIBB is a commercially available (AccuBoost, Billerica, MA) mammography-based, brachytherapy system in which the treatment applicators are centered on the planning target volume (PTV) to direct (192)Ir emissions along orthogonal axes. A privacy-encrypted online data registry collected information from 8 independent academic and community-based institutions. Data were from 146 consecutive women with early-stage breast cancer after lumpectomy and WBRT receiving boost with NIBB between July 2007 and March 2010. Toxicity and cosmesis were graded according to the Common Toxicity Criteria (v. 3.0) and the Harvard scale. Median follow-up was 6 months (1-39 months). Grade 1-2 skin toxicity was observed in 64%, 48%, and 21% during the acute (1-3 weeks), intermediate (4-26 weeks), and late-intermediate (>26 weeks) periods. There was no Grade 4 toxicity. At 6 months, for the entire cohort, cosmesis was excellent/good in 62%/38%. The subset receiving NIBB before WBRT had cosmetic scores of 32% and 63%, whereas during WBRT, 58% and 37% were rated as excellent and good, respectively. Breast compression was scored as "uncomfortable" in 12%, 29%, and 59% when NIBB was delivered before, during, or after WBRT. For each patient, the fraction-to-fraction variability in PTV was low. Skin flash was associated with a higher proportion of excellent cosmesis (58% vs. 42%) relative to having the applicator all within breast tissue. These data indicate that NIBB is feasible and can be consistently implemented in a broad array of practice settings. Preliminary evaluation suggests that NIBB is associated with acceptably mild normal tissue toxicity and favorable early cosmesis. The application of NIBB before WBRT may be associated with better patient tolerance at the expense of less favorable cosmetic outcome. Copyright © 2012

  20. Preliminary report of pulsed dose rate brachytherapy in head-and-neck cancer

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    Ziemlewski, A.; Zienkiewicz, J. [Medical Univ. of Gdansk (Poland). Dept. of Oral and Maxillofacial Surgery; Serkies, K.; Badzio, A. [Medical Univ. of Gdansk (Poland). Dept. of Oncology and Radiotherapy

    2007-09-15

    Purpose: To assess the feasibility and acute/delayed toxicity of pulsed-dose-rate brachytherapy (PDR BT) in head-and-neck tumors. Patients and Methods: 45 head and neck cancer patients underwent interstitial or contact PDR BT at a dose of 10.2-70 Gy (median, 70 Gy) and 0.6 or 1.0 Gy/pulse/h. 42 patients were administered BT as part of their curative treatment; 32 of them had sole BT. Three reirradiated patients with recurrent tumor had palliative BT. Results: PDR BT was well tolerated. Intense bleeding was the only complication associated with catheter removal from the tongue and bucca. 44 patients who completed BT experienced acute mucositis. Grade 3 toxicity of skin and oral mucosa occurred in three (6.8%) and six patients (13.6%), respectively. At a median follow-up of 22 months (range, 2-67 months), late serious toxicity (grade 4, for soft tissue and bone) was seen in seven patients (15.9%). Among the parameters analyzed, only dental care performed before BT had a significant impact on mucosal side effects. Acute severe mucositis was observed in 23% of patients without dental care compared to 0% of those with dental care (p = 0.044). Late severe mucositis occurred in 17.7% and 26.9% of the respective patients (p = 0.035), overall in 23%. The larger the volume encompassed by the reference isodose, the more late (p = 0.004) mucosal reactions were observed. Conclusion: PDR BT continued over a few days is a feasible and safe approach in head-and-neck tumors; however, it is accompanied by some toxicity. Dental care should precede isotope application. (orig.)

  1. Preliminary Results Towards Contract Monitorability

    Directory of Open Access Journals (Sweden)

    Annalizz Vella

    2016-05-01

    Full Text Available This paper discusses preliminary investigations on the monitorability of contracts for web service descriptions. There are settings where servers do not guarantee statically whether they satisfy some specified contract, which forces the client (i.e., the entity interacting with the server to perform dynamic checks. This scenario may be viewed as an instance of Runtime Verification, where a pertinent question is whether contracts can be monitored for adequately at runtime, otherwise stated as the monitorability of contracts. We consider a simple language of finitary contracts describing both clients and servers, and develop a formal framework that describes server contract monitoring. We define monitor properties that potentially contribute towards a comprehensive notion of contract monitorability and show that our simple contract language satisfies these properties.

  2. Reirradiation for recurrent head and neck cancer with salvage interstitial pulsed-dose-rate brachytherapy. Long-term results

    Energy Technology Data Exchange (ETDEWEB)

    Strnad, Vratislav; Lotter, Michael; Kreppner, Stephan; Fietkau, Rainer [University Hospital Erlangen, Dept. of Radiation Oncology, Erlangen (Germany)

    2015-01-10

    To assess the long-term results of protocol-based interstitial pulsed-dose-rate (PDR) brachytherapy as reirradiation combined with simultaneous chemotherapy and interstitial hyperthermia in selected patients with recurrent head and neck tumors. A total of 104 patients with biopsy-proven recurrent head and neck cancer were treated with interstitial PDR brachytherapy. Salvage surgery had also been undergone by 53/104 (51 %) patients (R1 or R2 resection in > 80 % of patients). Salvage brachytherapy alone was administered in 81 patients (78 %), with a median total dose of 56.7 Gy. Salvage brachytherapy in combination with external beam radiotherapy (EBRT) was performed in 23/104 patients (32 %), using a median total dose of D{sub REF} = 24 Gy. Simultaneously to PDR brachytherapy, concomitant chemotherapy was administered in 58/104 (55.8 %) patients. A single session of interstitial hyperthermia was also used to treat 33/104 (31.7 %) patients. The analysis was performed after a median follow-up of 60 months. Calculated according to Kaplan-Meier, local tumor control rates after 2, 5, and 10 years were 92.5, 82.4, and 58.9 %, respectively. Comparing results of salvage PDR brachytherapy with or without simultaneous chemotherapy, the 10-year local control rates were 76 vs. 39 % (p= 0014), respectively. No other patient- or treatment-related parameters had a significant influence on treatment results. Soft tissue necrosis or bone necrosis developed in 18/104 (17.3 %) and 11/104 (9.6 %) patients, respectively, but only 3 % of patients required surgical treatment. PDR interstitial brachytherapy with simultaneous chemotherapy is a very effective and, in experienced hands, also a safe treatment modality in selected patients with head and neck cancer in previously irradiated areas. (orig.) [German] Es erfolgte die Analyse der Langzeitergebnisse einer protokollbasierten interstitiellen Brachytherapie (Re-Bestrahlung) mit simultaner Chemotherapie und interstitieller Hyperthermie

  3. Perioperative Interstitial High-Dose-Rate Brachytherapy for the Treatment of Recurrent Keloids: Feasibility and Early Results

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Ping, E-mail: ping.jiang@uksh.de [Department of Radiation Oncology, University Clinic Schleswig-Holstein, Campus Kiel, Kiel (Germany); Baumann, René [Department of Radiation Oncology, University Clinic Schleswig-Holstein, Campus Kiel, Kiel (Germany); Dunst, Juergen [Department of Radiation Oncology, University Clinic Schleswig-Holstein, Campus Kiel, Kiel (Germany); Department of Radiation Oncology, University of Copenhagen, Copenhagen (Denmark); Geenen, Matthias [Department of Reconstructive Surgery, Lubinus Clinic Kiel, Kiel (Germany); Siebert, Frank-André [Department of Radiation Oncology, University Clinic Schleswig-Holstein, Campus Kiel, Kiel (Germany); Niehoff, Peter [Department of Radiation Oncology, University Clinic Schleswig-Holstein, Campus Kiel, Kiel (Germany); Department of Radiation Oncology, Community Clinic Köln, Köln (Germany); Department of Radiation Oncology, University Witten/Herdecke, Witten (Germany); Bertolini, Julia; Druecke, Daniel [Department of Reconstructive Surgery, University Clinic Schleswig-Holstein, Campus Kiel, Kiel (Germany)

    2016-03-01

    Purpose: To prospectively evaluate high-dose-rate brachytherapy in the treatment of therapy-resistant keloids and report first results, with emphasis on feasibility and early treatment outcome. Methods and Materials: From 2009 to 2014, 24 patients with 32 recurrent keloids were treated with immediate perioperative high-dose-rate brachytherapy; 3 patients had been previously treated with adjuvant external beam radiation therapy and presented with recurrences in the pretreated areas. Two or more different treatment modalities had been tried in all patients and had failed to achieve remission. After (re-)excision of the keloids, a single brachytherapy tube was placed subcutaneously before closing the wound. The target volume covered the scar in total length. Brachytherapy was given in 3 fractions with a single dose of 6 Gy in 5 mm tissue depth. The first fraction was given within 6 hours after surgery, the other 2 fractions on the first postoperative day. Thus, a total dose of 18 Gy in 3 fractions was administered within 36 hours after the resection. Results: The treatment was feasible in all patients. No procedure-related complications (eg, secondary infections) occurred. Nineteen patients had keloid-related symptoms before treatment like pain and pruritus; disappearance of symptoms was noticed in all patients after treatment. After a median follow-up of 29.4 months (range, 7.9-72.4 months), 2 keloid recurrences and 2 mildly hypertrophied scars were observed. The local control rate was 94%. Pigmentary abnormalities were detected in 3 patients, and an additional 6 patients had a mild delay in the wound-healing process. Conclusions: The early results of this study prove the feasibility and the efficacy of brachytherapy for the prevention of keloids. The results also suggest that brachytherapy may be advantageous in the management of high-risk keloids or as salvage treatment for failure after external beam therapy.

  4. Spectral CT evaluation of interstitial brachytherapy in pancreatic carcinoma xenografts: preliminary animal experience

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Shudong [Jiangsu University, Department of Radiology, The Affiliated Renmin Hospital, Zhenjiang, Jiangsu (China); Shanghai Jiao tong University, School of Medicine, Department of Radiology, Ruijin Hospital, Shanghai (China); Huang, Wei; Song, Qi; Lin, Xiaozhu; Wang, Zhongmin; Chen, Kemin [Shanghai Jiao tong University, School of Medicine, Department of Radiology, Ruijin Hospital, Shanghai (China); Chen, Yerong [Jiangsu University, Department of Radiology, The Affiliated Renmin Hospital, Zhenjiang, Jiangsu (China)

    2014-09-15

    We sought to evaluate the capability of spectral CT to detect the therapeutic response to {sup 125}I interstitial brachytherapy in a pancreatic carcinoma xenograft nude mouse model. Twenty mice bearing SWl990 human pancreatic cancer cell xenografts were randomly separated into two groups: experimental (n = 10; 1.0 mCi) and control (n = 10; 0 mCi). After a two-week treatment, spectral CT was performed. Contrast-to-noise ratio (CNR) and iodine concentration (IC) in the lesions were measured and normalized to the muscle tissue, and nIC CD31 immunohistochemistry was used to measure microvessel density (MVD). The relationships between the nIC and MVD of the tumours were analysed. The nIC of the experimental group was significantly lower than that of the control group during the multiphase examination. A significant difference in the MVD was observed between the two groups (P <0.001). The nIC values of the three-phase scans have a certain positive correlation with MVD (r = 0.57, p < 0.0001; r = 0.48, p = 0.002; r = 0.63, p = 0.0017 in the 10, 25, and 60 s phase, respectively). Spectral CT can be a useful non-invasive imaging modality in evaluating the therapeutic effect of {sup 125}I interstitial brachytherapy to a pancreatic carcinoma. (orig.)

  5. A Multi-Institutional Study of Feasibility, Implementation, and Early Clinical Results With Noninvasive Breast Brachytherapy for Tumor Bed Boost

    Energy Technology Data Exchange (ETDEWEB)

    Hamid, Subarna, E-mail: shamid@tuftsmedicalcenter.org [Department of Radiation Oncology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA (United States); Department of Radiation Oncology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI (United States); Rocchio, Kathy [Department of Radiation Oncology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI (United States); Arthur, Douglas; Vera, Robyn [Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA (United States); Sha, Sandra; Jolly, Michele [Central Florida Cancer Institute, Davenport, FL (United States); Cavanaugh, Sean; Wooten, Eric [Atlanta Oncology Associates, Hawkinsville, GA (United States); Benda, Rashmi; Greenfield, Brad [Department of Radiation Oncology, Boca Raton Community Hospital, Boca Raton, FL (United States); Prestidge, Bradley [Texas Cancer Clinic, San Antonio, TX (United States); Ackerman, Scot [First Coast Oncology, Jacksonville, FL (United States); Kuske, Robert; Quiet, Coral; Snyder, Margaret [Arizona Breast Cancer Specialists, Phoenix, AZ (United States); Wazer, David E. [Department of Radiation Oncology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA (United States); Department of Radiation Oncology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI (United States)

    2012-08-01

    Purpose: To evaluate the feasibility, implementation, and early results of noninvasive breast brachytherapy (NIBB) for tumor bed boost with whole breast radiation therapy (WBRT). Methods and Materials: NIBB is a commercially available (AccuBoost, Billerica, MA) mammography-based, brachytherapy system in which the treatment applicators are centered on the planning target volume (PTV) to direct {sup 192}Ir emissions along orthogonal axes. A privacy-encrypted online data registry collected information from 8 independent academic and community-based institutions. Data were from 146 consecutive women with early-stage breast cancer after lumpectomy and WBRT receiving boost with NIBB between July 2007 and March 2010. Toxicity and cosmesis were graded according to the Common Toxicity Criteria (v. 3.0) and the Harvard scale. Median follow-up was 6 months (1-39 months). Results: Grade 1-2 skin toxicity was observed in 64%, 48%, and 21% during the acute (1-3 weeks), intermediate (4-26 weeks), and late-intermediate (>26 weeks) periods. There was no Grade 4 toxicity. At 6 months, for the entire cohort, cosmesis was excellent/good in 62%/38%. The subset receiving NIBB before WBRT had cosmetic scores of 32% and 63%, whereas during WBRT, 58% and 37% were rated as excellent and good, respectively. Breast compression was scored as 'uncomfortable' in 12%, 29%, and 59% when NIBB was delivered before, during, or after WBRT. For each patient, the fraction-to-fraction variability in PTV was low. Skin flash was associated with a higher proportion of excellent cosmesis (58% vs. 42%) relative to having the applicator all within breast tissue. Conclusions: These data indicate that NIBB is feasible and can be consistently implemented in a broad array of practice settings. Preliminary evaluation suggests that NIBB is associated with acceptably mild normal tissue toxicity and favorable early cosmesis. The application of NIBB before WBRT may be associated with better patient tolerance

  6. Cyclonic valve test: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Monteiro, Andre Sampaio; Moraes, Carlos Alberto C.; Marins, Luiz Philipe M.; Soares, Fabricio; Oliveira, Dennis; Lima, Fabio Soares de; Airao, Vinicius [Petroleo Brasileiro S.A. (PETROBRAS), Rio de Janeiro, RJ (Brazil); Ton, Tijmen [Twister BV, Rijswijk (Netherlands)

    2012-07-01

    For many years, the petroleum industry has been developing a valve that input less shear to the flow for a given required pressure drop and this can be done using the cyclonic concept. This paper presents a comparison between the performances of a cyclonic valve (low shear) and a conventional globe valve. The aim of this work is to show the advantages of using a cyclonic low shear valve instead of the commonly used in the primary separation process by PETROBRAS. Tests were performed at PETROBRAS Experimental Center (NUEX) in Aracaju/SE varying some parameters: water cut; pressure loss (from 4 kgf/cm2 to 10 kgf/cm2); flow rates (30 m3/h and 45 m3/h). Results indicates a better performance of the cyclonic valve, if compared with a conventional one, and also that the difference of the performance, is a function of several parameters (emulsion stability, water content free, and oil properties). The cyclonic valve tested can be applied as a choke valve, as a valve between separation stages (for pressure drop), or for controlling the level of vessels. We must emphasize the importance to avoid the high shear imposed by conventional valves, because once the emulsion is created, it becomes more difficult to break it. New tests are being planned to occur in 2012, but PETROBRAS is also analyzing real cases where the applications could increase the primary process efficiency. In the same way, the future installations are also being designed considering the cyclonic valve usage. (author)

  7. Low-dose-rate brachytherapy for patients with transurethral resection before implantation in prostate cancer: long-term results

    Energy Technology Data Exchange (ETDEWEB)

    Prada, Pedro J.; Anchuelo, Javier; Blanco, Ana Garcia; Paya, Gema; Cardenal, Juan; Acuña, Enrique; Ferri, Maria [Department of Radiation Oncology, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria (Spain); Vazquez, Andres; Pacheco, Maite; Sanchez, Jesica [Department of Radiation Physics, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria (Spain)

    2016-01-15

    Objectives: We analyzed the long-term oncologic outcome for patients with prostate cancer and transurethral resection who were treated using low-dose-rate (LDR) prostate brachytherapy. Methods and Materials: From January 2001 to December 2005, 57 consecutive patients were treated with clinically localized prostate cancer. No patients received external beam radiation. All of them underwent LDR prostate brachytherapy. Biochemical failure was defined according to the 'Phoenix consensus'. Patients were stratified as low and intermediate risk based on The Memorial Sloan Kettering group definition. Results: The median follow-up time for these 57 patients was 104 months. The overall survival according to Kaplan-Meier estimates was 88% (±6%) at 5 years and 77% (±6%) at 12 years. The 5 and 10 years for failure in tumour-free survival (TFS) was 96% and respectively (±2%), whereas for biochemical control was 94% and respectively (±3%) at 5 and 10 years, 98% (±1%) of patients being free of local recurrence. A patient reported incontinence after treatment (1.7%). The chronic genitourinary complains grade I were 7% and grade II, 10%. At six months 94% of patients reported no change in bowel function. Conclusions: The excellent long-term results and low morbidity presented, as well as the many advantages of prostate brachytherapy over other treatments, demonstrates that brachytherapy is an effective treatment for patients with transurethral resection and clinical organ-confined prostate cancer. (author)

  8. Modern prostate brachytherapy. Prostate specific antigen results in 219 patients with up to 12 years of observed follow-up.

    Science.gov (United States)

    Ragde, H; Korb, L J; Elgamal, A A; Grado, G L; Nadir, B S

    2000-07-01

    The purported lack of long term modern prostate brachytherapy outcome data continues to lead many physicians to recommend other, more traditional treatments. This concern for long term results has encouraged the authors to supplement their earlier 10-year follow-up of patients receiving brachytherapy; in the process, an additional 77 patients (> 50%) were added to the original cohort, and the follow-up time was increased by 2 years. Between January 1987 and September 1989, 229 patients with T1-T3 prostate carcinoma underwent transperineal prostate brachytherapy using iodine-125 (I-125). No patient received adjuvant hormone therapy. The median Gleason sum was 5 (range, 2-10). Of these patients, 147 were determined to have a high probability of organ-confined disease and were treated solely with an I-125 implant. The remaining 82 patients were determined to be at increased risk for extracapsular disease and received pelvic external beam radiation in addition to brachytherapy. All patients were followed continuously. Failure was defined as a positive biopsy, radiographic evidence of metastases, or three consecutive rises in prostate specific antigen (PSA) levels as defined by the American Society for Therapeutic Radiology and Oncology (ASTRO) consensus article. Excluding deaths from intercurrent disease, the median follow-up was 122 months (range, 18-144 months). Fourteen patients were excluded from analysis due to insufficient follow-up. Adopting the ASTRO definition of failure resulted in minimal change in survival when compared with the authors' previous study, which used a PSA level > 0.5 ng/mL as the failure point. Observed 10-year disease free survival (DFS) for the entire cohort was 70%. In the brachytherapy only group, the observed 10-year DFS was 66%, whereas those patients treated with the addition of external pelvic radiation achieved a DFS of 79%. None of the patients who were followed for the full 12 years failed between Years 10 and 12. Only 25% of the

  9. Patterns of care study for brachytherapy: results of the questionnaire for the years 2002 and 2007 in The Netherlands

    Directory of Open Access Journals (Sweden)

    Bradley Londres

    2010-01-01

    Full Text Available Purpose: The goal of the ESTRO Patterns of Care study for Brachytherapy in Europe (PCBE 2002 was to develop an aid to analyse brachytherapy practices. A 2nd version of the PCB questionnaire was created for 2007. Data over 2007 were collected at the radiotherapy institutions in The Netherlands and compared with those from 2002. The aim of this study is to describe national brachytherapy practices, to demonstrate trends, and to provide data for rational health care planning.Material and methods: Data were collected using a web-based questionnaire. For each centre, a local coordinator, responsible for coordinating the questionnaires and support of the further analysis was assigned. Data from the national cancer incidence registry was used for comparison with the data from the 21 Dutch departments.Results: There was a decrease in low-dose rate equipment in parallel to an increase in both pulsed-dose rate and high-dose rate equipment. The use of 3D CT and MR based imaging techniques showed a slow rise. The most common clinical procedures were for prostate, gynaecological, and oesophageal tumours. A large increase (146% in permanent implant prostate applications using 125I seeds was observed. The numbers of oesophageal and gynaecological treatmentsremained stable. There is concern on the low numbers of cases treated in some institutions for a few complex treatment sites. For head and neck, anal canal, paediatrics, bladder and eye interventions it ranged from 3-20 patients per year per institution.Conclusions: The increase in number of patient treated with brachytherapy is in accordance with the increases in cancer incidence. The percentage of all radiotherapy patients treated with brachytherapy (approximately 5% remained stable. The survey identified certain trends in resources and techniques, as well as areas of expected improvement and possible gain in clinical outcome. Data reported from this survey can be used for further planning of resources

  10. Implementation of the global risk analysis in pulsed-dose rate brachytherapy: methods and results.

    Science.gov (United States)

    Mazeron, R; Aguini, N; Rivin Del Campo, E; Dumas, I; Gensse, M-C; Brusadin, G; Lefkopoulos, D; Deutsch, E; Haie-Meder, C

    2015-04-01

    To report the application of the global risk analysis (GRA) in the pulsed-dose rate (PDR) brachytherapy workflow. Analyses were led by a multidisciplinary working group established within the unit with the guidance of a quality engineer. First, a mapping of hazardous situations was developed as a result of interactions between the patient workflow for a treatment using PDR brachytherapy split into 51 sub-phases with a comprehensive list of the hazards that he/she faces (44). Interactions, when relevant, were sorted by level of priority: to be treated immediately, secondarily (the group is not entitled to treat the situation), or later (safe situation). Secondly, for each high priority dangerous situation, scenarios were developed to anticipate their potential consequences. Criticality was assessed, using likelihood and severity scales and a matrix, which allocated risks into categories: acceptable (C1), tolerable under control (C2) and unacceptable (C3). Then, corrective actions were proposed and planned when relevant, after assessment of their feasibility with a scale of effort. Finally, the criticality of the scenarios was reevaluated, taking into account the implementation of these actions, leading to a residual risk mapping, which could trigger additional proposals of actions. Two thousand one hundred and eighty-four potential interactions between the list of hazards and the workflow were analyzed. Mapping of dangerous situations identified 213 relevant interactions, from which 61 were considered with high priority. One hundred and twenty-six scenarios were generated: 68 with a low criticality (74.3%), 58 with an intermediate score (25.7%). No scenario with the highest criticality was individualized. Twenty-one corrective actions were planned. Mapping of residual risk resulted in the disappearance of most C2 risks, leaving 5 C2 scenarios (4%), for which four monitoring indicators were implemented in addition to the corrected actions decided on. The

  11. Preliminary results in surgery of Parkinson's disease.

    Science.gov (United States)

    Nasser, J A; Confort, C I; Ferraz, A; Bouza, A A

    1998-09-01

    The authors present the preliminary results of 20 patients selected to be operated on between January 1996 and April 1997. These patients presented one of the present indications for stereotactic posteroventral pallidotomy (PVP), such as: rigidity, akinesia/bradykinesia, gait dysfunction, drug induced dyskinesias and tremor. Every patient of this protocol was evaluated by: UPDRS score, Schwab and England scale, Hoehn and Yahr Staging Scale before and after surgery. The results in 3 months showed a remarkable improvement after PVP (P < 0.01) in all functional assessments, except for facial expression, speech and posture. The morbidity was 5%. 5 patients (25%) who were in Hoehn and Yahr 5 underwent a bilateral simultaneous PVP. In 5 patients (25%), who had tremor, during the PVP, VIM thalamotomy was added. These preliminary results, suggest that PVP is highly effective for PD symptoms.

  12. Comparative results of three short brachytherapy schedules as exclusive treatment in postoperative endometrial carcinoma.

    Science.gov (United States)

    Rovirosa, Ángeles; Herreros, Antonio; Camacho, Cristina; Ascaso, Carlos; Sánchez, Joan; Cortés, Stepphania; Sabater, Sebastià; Solà, Jordi; Torné, Aureli; Arenas, Meritxell

    2017-08-08

    To compare vaginal control and treatment toxicity of three different high-dose-rate brachytherapy schedules as exclusive treatment in postoperative endometrial carcinoma. From 2003 to 2015, three different schedules were used as postoperative treatment for 146 patients (p) with intermediate-risk endometrial carcinoma. Group 1 (41 p): six fractions of 4-6 Gy, 3-4 fractions per week; Group 2 (59 p): four fractions of 5-6 Gy administered daily; Group 3 (46 p): 6 Gy × 3 fractions in three consecutive days. The dose was prescribed at 5 mm of applicator surface using an active treatment length of 2.5 cm. Toxicity scores were evaluated using the Radiation Therapy Oncology Group scores for bladder and rectum and the objective criteria of late effects of normal tissues-subjective, objective, management, analytic for vagina. Statistics used were group descriptions calculating their means, medians, and ranges. Bivariate analysis was evaluated using variance models and χ(2) tests. The mean followup was as follows: Group 1: 88 months, Group 2: 75 months, and 41 months in Group 3. No vaginal relapses were found. Late toxicity ≥ G2: rectum: 0 p in the three groups (0%). Bladder: Group 1: 1 p (2.4%), Group 2: 0%, and Group 3: 0%. Vagina: Group 1: 4 p (9.5%); Group 2: 9 p (15.3%); and Group 3:10 p (21.8%). There were no differences in late toxicity among the three groups of patients for rectum (p = 0.83), bladder (p = 0.58), and vagina (p = 0.67); the expected global risk of complications for rectum, bladder, and vagina is 0.8%, 0.8%, and 28.8%, respectively. Similar results in vaginal control and complications were achieved with the three schedules. The use of three fractions of 6 Gy administered daily is the best option for patient comfort and convenience and use of resources. Nonetheless, specific studies are needed to demonstrate the best cost-efficacy regime. Copyright © 2017 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

  13. [Ethnic entrepreneurship in Montreal: some preliminary results].

    Science.gov (United States)

    Juteau, D; Daviau-guay, J; Moallem, M

    1992-01-01

    "This research note presents a first sketch of a study we are undertaking on ethnic entrepreneurship [in Montreal]. It details first of all our theoretical framework and then presents some preliminary results. For this research, we are studying various ethnic groups, those in the majority as well as the minority. For each of them, we will analyze the impact that immigration status, sex, the industrial sector and urban context play on entrepreneurial activity." (SUMMARY IN ENG AND SPA) excerpt

  14. High-dose-rate interstitial brachytherapy for accelerated partial breast irradiation – trial results of Azerbaijan National Center of Oncology

    Directory of Open Access Journals (Sweden)

    Jamil A. Aliyev

    2017-04-01

    Full Text Available Purpose : To describe early results of two cohorts of patients with low and intermediate risk of early breast cancer treated with accelerated partial breast irradiation (APBI using different schedules of multicatheter brachytherapy. Material and methods: Patients with early stage breast cancer after breast conserving surgery were enrolled for a prospective analysis. The APBI, using multicatheter brachytherapy, was delivered either eight times 4 Gy in five days with a planned total dose of 32 Gy, or seven times 5 Gy in four days with a planned total dose of 35 Gy. Primary endpoints were side effects. Results : Forty-eight patients were enrolled between 2012 and 2014. Patients characteristics were as follow: median age of patients was 55 years, early breast cancer was defined according GEC-ESTRO recommendations. With a median follow-up period of 37 months, no significant differences regarding late side effects and cosmesis between two cohorts of patients were documented. In total, cosmesis was excellent in 13/48 (27.1% patients, good in 34/48 (70.8% patients, and moderate in 1/48 patient (2.1%. Conclusions : Accelerated partial breast irradiation using multicatheter brachytherapy with 32 Gy/8 fractions and 35 Gy/7 fractions for early breast cancer seems to be similar in terms of late side effects. According to our findings, APBI was also feasible for intermediate-risk of early breast cancer patients.

  15. Computed tomography-guided implantation of 125 I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results

    Directory of Open Access Journals (Sweden)

    Jie Li

    2017-04-01

    Full Text Available Purpose : To retrospectively evaluate the efficacy and safety of computed tomography (CT-guided percutaneous interstitial brachytherapy using 125 I radioactive seeds for multiple pulmonary metastatic tumors. Material and methods : Between September 2013 and December 2015, 22 patients with multiple pulmonary metastases, who after conventional chemotherapy and trans-arterial chemoembolization (TACE therapy were considered unable to withstand stereotactic body radiation therapy (SBRT, received CT-guided 125 I brachytherapy. Clinical data were studied retrospectively. A planning target volume of 90% (D90 was 120-160 Gy for 125 I seeds with an activity of 25.9 MBq. A CT-based evaluation performed 1, 2, and 6 months’ post-implantation enabled review of local control of tumors. Results : Twenty-two patients with 65 pulmonary metastases successfully completed treatment. The mean value for D90 for implantation for 125 I seeds was 132 Gy. Complete response (CR + partial response (PR was documented in 81.54%, 78.46%, and 78.46% of patients at 1, 2, and 6 months after implantation, respectively. Fourteen out of 22 patients had CR, 3 had PR, 2 had stable disease (SD, and 3 had progressive disease (PD. Most of the metastases (CR + PR + SD; 87.69% after 6 months were controlled by implantation. Conclusions : CT-guided 125 I brachytherapy is a safe and effective treatment for multiple pulmonary metastatic tumors, and can achieve good short-term local control, so long as the radiation dose is sufficient.

  16. Brachytherapy in lip cancer.

    Science.gov (United States)

    Rovirosa-Casino, Angeles; Planas-Toledano, Isabel; Ferre-Jorge, Jorge; Oliva-Díez, José María; Conill-Llobet, Carlos; Arenas-Prat, Meritxell

    2006-05-01

    Lip cancer is one of the most prevalent skin tumours of the head and neck. The characteristics of the tumour relate to their exophyitic growth in an area of easy visual acces which allows their diagnosis in early stages. As a result, there is a better prognosis with the present treatments. In early stages the treatment can be performed by surgery or by brachytherapy, and the results are similar on local control; nevertheless brachytherapy offers the best functional and esthetic results. We are reporting on a review of the literature in relation to indications, techniques and results of brachytherapy for lip cancer.

  17. Visual perception skills testing: preliminary results

    CSIR Research Space (South Africa)

    Smith, Adrew C

    2009-02-01

    Full Text Available stream_source_info Smith_d4_2009.pdf.txt stream_content_type text/plain stream_size 7318 Content-Encoding UTF-8 stream_name Smith_d4_2009.pdf.txt Content-Type text/plain; charset=UTF-8 Visual Perception Skills Testing...: Preliminary Results Andrew Cyrus Smith CSIR Meraka Institute PO Box 395 Pretoria, 0001, South Africa +27 12 841 4626 acsmith @ csir.co.za ABSTRACT Good visual perception skills are important in the effective manipulation of Tangible User...

  18. Conventional Versus Automated Implantation of Loose Seeds in Prostate Brachytherapy: Analysis of Dosimetric and Clinical Results

    Energy Technology Data Exchange (ETDEWEB)

    Genebes, Caroline, E-mail: genebes.caroline@claudiusregaud.fr [Radiation Oncology Department, Institut Claudius Regaud, Toulouse (France); Filleron, Thomas; Graff, Pierre [Radiation Oncology Department, Institut Claudius Regaud, Toulouse (France); Jonca, Frédéric [Department of Urology, Clinique Ambroise Paré, Toulouse (France); Huyghe, Eric; Thoulouzan, Matthieu; Soulie, Michel; Malavaud, Bernard [Department of Urology and Andrology, CHU Rangueil, Toulouse (France); Aziza, Richard; Brun, Thomas; Delannes, Martine; Bachaud, Jean-Marc [Radiation Oncology Department, Institut Claudius Regaud, Toulouse (France)

    2013-11-15

    Purpose: To review the clinical outcome of I-125 permanent prostate brachytherapy (PPB) for low-risk and intermediate-risk prostate cancer and to compare 2 techniques of loose-seed implantation. Methods and Materials: 574 consecutive patients underwent I-125 PPB for low-risk and intermediate-risk prostate cancer between 2000 and 2008. Two successive techniques were used: conventional implantation from 2000 to 2004 and automated implantation (Nucletron, FIRST system) from 2004 to 2008. Dosimetric and biochemical recurrence-free (bNED) survival results were reported and compared for the 2 techniques. Univariate and multivariate analysis researched independent predictors for bNED survival. Results: 419 (73%) and 155 (27%) patients with low-risk and intermediate-risk disease, respectively, were treated (median follow-up time, 69.3 months). The 60-month bNED survival rates were 95.2% and 85.7%, respectively, for patients with low-risk and intermediate-risk disease (P=.04). In univariate analysis, patients treated with automated implantation had worse bNED survival rates than did those treated with conventional implantation (P<.0001). By day 30, patients treated with automated implantation showed lower values of dose delivered to 90% of prostate volume (D90) and volume of prostate receiving 100% of prescribed dose (V100). In multivariate analysis, implantation technique, Gleason score, and V100 on day 30 were independent predictors of recurrence-free status. Grade 3 urethritis and urinary incontinence were observed in 2.6% and 1.6% of the cohort, respectively, with no significant differences between the 2 techniques. No grade 3 proctitis was observed. Conclusion: Satisfactory 60-month bNED survival rates (93.1%) and acceptable toxicity (grade 3 urethritis <3%) were achieved by loose-seed implantation. Automated implantation was associated with worse dosimetric and bNED survival outcomes.

  19. Preliminary results of ground-motion characteristics

    Directory of Open Access Journals (Sweden)

    Francesca Bozzoni

    2012-10-01

    Full Text Available The preliminary results are presented herein for the engineering applications of the characteristics of the ground motion induced by the May 20, 2012, Emilia earthquake. Shake maps are computed to provide estimates of the spatial distribution of the induced ground motion. The signals recorded at the Mirandola (MRN station, the closest to the epicenter, have been processed to obtain acceleration, velocity and displacement response spectra. Ground-motion parameters from the MRN recordings are compared with the corresponding estimates from recent ground-motion prediction equations, and with the spectra prescribed by the current Italian Building Code for different return periods. The records from the MRN station are used to plot the particle orbit (hodogram described by the waveform. The availability of results from geotechnical field tests that were performed at a few sites in the Municipality of Mirandola prior to this earthquake of May 2012 has allowed preliminary assessment of the ground response. The amplification effects at Mirandola are estimated using fully stochastic site-response analyses. The seismic input comprises seven actual records that are compatible with the Italian code-based spectrum that refers to a 475-year return period. The computed acceleration response spectrum and the associated dispersion are compared to the spectra calculated from the recordings of the MRN station. Good agreement is obtained for periods up to 1 s, especially for the peak ground acceleration. For the other periods, the spectral acceleration of the MRN recordings exceeds that of the computed spectra.

  20. Re-irradiation of the chest wall for local breast cancer recurrence. Results of salvage brachytherapy with hyperthermia

    Energy Technology Data Exchange (ETDEWEB)

    Auoragh, A. [University Hospital Erlangen, Department of Radiation Oncology, Erlangen (Germany); Hospital Fuerth, Department of Radiation Oncology, Fuerth (Germany); Strnad, V.; Ott, O.J.; Fietkau, R. [University Hospital Erlangen, Department of Radiation Oncology, Erlangen (Germany); Beckmann, M.W. [University Hospital Erlangen, Department of Gynecology and Obstetrics, Erlangen (Germany)

    2016-09-15

    Following mastectomy and adjuvant external beam radiation therapy in patients with breast cancer, the incidence of local or locoregional recurrence is approximately 9 % (2-20 %). Alongside the often limited possibilities of surgical treatment, radiation therapy combined with superficial hyperthermia is the most effective local therapy. In the present work, a retrospective analysis of salvage brachytherapy combined with superficial hyperthermia for chest wall recurrences is presented. Between 2004 and 2011, 18 patients with a total of 23 target volumes resulting from chest wall recurrences after previously mastectomy and external beam radiation therapy (median 56 Gy, range 50-68 Gy) were treated with superficial brachytherapy as salvage treatment: 8 patients (44 %) had macroscopic tumor, 3 (17 %) had microscopic tumor (R1), and 7 (39 %) had undergone R0 resection and were treated due to risk factors. A dose of 50 Gy was given (high-dose rate [HDR] and pulsed-dose rate [PDR] procedures). In all, 5 of 23 patients (22 %) received additional concurrent chemotherapy, and in 20 of 23 (87 %) target volumes additional superficial hyperthermia was carried out twice weekly. The 5-year local recurrence-free survival was 56 %, the disease-free survival was 28 %, and a 5-year overall survival was 22 %. Late side effects Common Toxicity Criteria (CTC) grade 3 were reported in 17 % of the patients: 2 of 18 (11 %) had CTC grade 3 fibrosis, and 1 of 18 (6 %) had a chronic wound healing disorder. Re-irradiation as salvage brachytherapy with superficial hyperthermia for chest wall recurrences is a feasible and safe treatment with good local control results and acceptable late side effects. (orig.) [German] Nach einer Mastektomie und adjuvanter Strahlentherapie bei Patientinnen mit Mammakarzinom kommt es bei 9 % (2-20 %) zum lokalen bzw. lokoregionaeren Rezidiv. Neben den oft limitierten operativen Behandlungsmoeglichkeiten ist die Strahlentherapie mit Oberflaechenhyperthermie die

  1. Long-Term Results of a Randomized Trial in Locally Advanced Rectal Cancer: No Benefit From Adding a Brachytherapy Boost

    Energy Technology Data Exchange (ETDEWEB)

    Appelt, Ane L., E-mail: ane.lindegaard.appelt@rsyd.dk [Department of Oncology, Vejle Hospital, Vejle (Denmark); Faculty of Health Sciences, University of Southern Denmark, Odense (Denmark); Vogelius, Ivan R. [Department of Radiation Oncology, Rigshospitalet, University of Copenhagen, Copenhagen (Denmark); Pløen, John; Rafaelsen, Søren R.; Lindebjerg, Jan; Havelund, Birgitte M. [Danish Colorectal Cancer Group South, Vejle Hospital, Vejle (Denmark); Bentzen, Søren M. [Division of Biostatistics and Bioinformatics, University of Maryland Greenebaum Cancer Center, and Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland (United States); Jakobsen, Anders [Faculty of Health Sciences, University of Southern Denmark, Odense (Denmark); Danish Colorectal Cancer Group South, Vejle Hospital, Vejle (Denmark)

    2014-09-01

    Purpose/Objective(s): Mature data on tumor control and survival are presented from a randomized trial of the addition of a brachytherapy boost to long-course neoadjuvant chemoradiation therapy (CRT) for locally advanced rectal cancer. Methods and Materials: Between March 2005 and November 2008, 248 patients with T3-4N0-2M0 rectal cancer were prospectively randomized to either long-course preoperative CRT (50.4 Gy in 28 fractions, per oral tegafur-uracil and L-leucovorin) alone or the same CRT schedule plus a brachytherapy boost (10 Gy in 2 fractions). The primary trial endpoint was pathologic complete response (pCR) at the time of surgery; secondary endpoints included overall survival (OS), progression-free survival (PFS), and freedom from locoregional failure. Results: Results for the primary endpoint have previously been reported. This analysis presents survival data for the 224 patients in the Danish part of the trial. In all, 221 patients (111 control arm, 110 brachytherapy boost arm) had data available for analysis, with a median follow-up time of 5.4 years. Despite a significant increase in tumor response at the time of surgery, no differences in 5-year OS (70.6% vs 63.6%, hazard ratio [HR] = 1.24, P=.34) and PFS (63.9% vs 52.0%, HR=1.22, P=.32) were observed. Freedom from locoregional failure at 5 years were 93.9% and 85.7% (HR=2.60, P=.06) in the standard and in the brachytherapy arms, respectively. There was no difference in the prevalence of stoma. Explorative analysis based on stratification for tumor regression grade and resection margin status indicated the presence of response migration. Conclusions: Despite increased pathologic tumor regression at the time of surgery, we observed no benefit on late outcome. Improved tumor regression does not necessarily lead to a relevant clinical benefit when the neoadjuvant treatment is followed by high-quality surgery.

  2. Overweight and urban pollution: preliminary results.

    Science.gov (United States)

    Ponticiello, Barnaba Giuseppina; Capozzella, Assunta; Di Giorgio, Valeria; Casale, Teodorico; Giubilati, Roberto; Tomei, Gianfranco; Tomei, Francesco; Rosati, Maria Valeria; Sancini, Angela

    2015-06-15

    The aim of this study is to determine whether in workers exposed to urban pollution the risk of developing overweight and obesity is higher in workers exposed to urban pollution compared to a control group. The study was conducted on 150 volunteers, 75 workers exposed to urban pollution (50 women and 25 men) and 75 indoor workers (50 women and 25 men). Once measured the weight and height and calculated body mass index (BMI) for each worker, the research was based on the comparison, between the two groups, of the mean values of the measurements and of the frequency of workers with BMI index higher than the cut-off of normality. The only statistically significant difference found was for the mean value of weight in women, which was higher among outdoor workers compared to indoor workers. The mean values of BMI and the frequency of workers with BMI higher than normal was higher among outdoor workers compared to indoor workers in both sexes, but not statistically significant. The data suggest that outdoor workers may be subject to an additional risk of developing obesity as a result of exposure to urban air pollution (which, like obesity, is a source of oxidative stress). So, our preliminary study encourages to continue this line of research by implementing the sample and considering all the confounding factors. Furthermore, the results highlight the necessity to take account of gender differences in the context of health surveillance of workers. Copyright © 2015. Published by Elsevier B.V.

  3. Treatment results of brachytherapy vs. external beam radiation therapy for intermediate-risk prostate cancer with 10-year followup.

    Science.gov (United States)

    Goy, Barry W; Soper, Margaret S; Chang, Tangel; Slezak, Jeff M; Cosmatos, Harry A; Tome, Michael

    To compare 10-year treatment outcomes of brachytherapy vs. external beam radiation therapy for patients with intermediate-risk prostate cancer (IRPC). Between 2004 and 2007, 93 IRPC patients underwent brachytherapy using iodine-125 to a dose of 145 Gy without supplemental external radiation. A retrospective comparison was performed to a contemporary cohort of 597 patients treated with external beam radiation therapy to a median dose of 75.3 Gy using a propensity score-matched analysis. Median followup was 7.8 years. With brachytherapy, 51.6% had Gleason score 7 vs. 72.0% for external radiation (p brachytherapy vs. 9.4 for external radiation (p = 0.01). Neoadjuvant androgen deprivation therapy was given in 59.5% of external radiation vs. 10.8% of brachytherapy patients (p brachytherapy was 81.7% vs. 54.5% for external radiation (p = 0.002). Unfavorable intermediate-risk patients experienced borderline significant improved FFBF with brachytherapy (p = 0.08). The 10-year freedom from salvage therapy for brachytherapy was 93.2% vs. 72.2% for external radiation (p = 0.006). There were no significant differences in distant metastases-free survival, prostate cancer-specific survival, or overall survival after adjusting for age. Multivariate analysis with propensity score matching showed that brachytherapy remained an independent predictor for improved FFBF (p = 0.007). Grade 1 and 2 late rectal complication rate was 6.5% for brachytherapy vs. 15.2% for external radiation (p = 0.02). Brachytherapy using iodine-125 without supplemental external radiation is a reasonable treatment option for selected IRPC patients. Copyright © 2016 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

  4. Long-term results of a randomized trial in locally advanced rectal cancer: no benefit from adding a brachytherapy boost

    DEFF Research Database (Denmark)

    Appelt, Ane L; Vogelius, Ivan R; Pløen, John

    2014-01-01

    complete response (pCR) at the time of surgery; secondary endpoints included overall survival (OS), progression-free survival (PFS), and freedom from locoregional failure. RESULTS: Results for the primary endpoint have previously been reported. This analysis presents survival data for the 224 patients...... in the Danish part of the trial. In all, 221 patients (111 control arm, 110 brachytherapy boost arm) had data available for analysis, with a median follow-up time of 5.4 years. Despite a significant increase in tumor response at the time of surgery, no differences in 5-year OS (70.6% vs 63.6%, hazard ratio [HR......] = 1.24, P=.34) and PFS (63.9% vs 52.0%, HR=1.22, P=.32) were observed. Freedom from locoregional failure at 5 years were 93.9% and 85.7% (HR=2.60, P=.06) in the standard and in the brachytherapy arms, respectively. There was no difference in the prevalence of stoma. Explorative analysis based...

  5. Preliminary test results for the SVX4

    Energy Technology Data Exchange (ETDEWEB)

    Christofek, L.; Hanagaki, K.; Rapidis, P.; Utes, M.; /Fermilab

    2005-06-01

    We present and summarize the preliminary test results for SVX4 chip testing. There are presently two versions of the SVX4. Version 2 has on-chip bypassing and Version 1 does not. The on-chip bypassing is a layer of transistors under the front-end analog pipeline that acts as a bypassing capacitor for the voltage supply. Its size is about a microfarad. We aggressively choose to test Version 2 because of this feature. The feature is advantageous for hybrid design because it eliminates the need for an additional passive component on the hybrid itself by placing it on the actual SVX4 die. Also, the SVX4 was designed to operate in two modes: D. and CDF. One can set which mode the chip will operate by placing a jumper in the proper position on the SVX4 chip carrier. In either mode, the chip can either use the operating parameters from the shift register or the shadow register. Similarly, this is selected by placing a jumper on the SVX4 chip carrier. This chip has this feature because it was unknown whether the new design of the shadow register would be operable. The shadow register is also call the SEU register or Single Event Upset register. An introduction into the functionality of the chip and an explanation on the difference between D. and CDF mode can be found in the SVX4 User's Manual [1].

  6. High-Dose-Rate Brachytherapy as Monotherapy Delivered in Two Fractions Within One Day for Favorable/Intermediate-Risk Prostate Cancer: Preliminary Toxicity Data

    Energy Technology Data Exchange (ETDEWEB)

    Ghilezan, Michel, E-mail: mghilezan@beaumont.edu [Department of Radiation Oncology, William Beaumont Hospital and Rose Cancer Institute, Royal Oak, Michigan (United States); Martinez, Alvaro; Gustason, Gary; Krauss, Daniel; Antonucci, J. Vito; Chen, Peter; Fontanesi, James; Wallace, Michelle; Ye Hong; Casey, Alyse; Sebastian, Evelyn; Kim, Leonard; Limbacher, Amy [Department of Radiation Oncology, William Beaumont Hospital and Rose Cancer Institute, Royal Oak, Michigan (United States)

    2012-07-01

    Purpose: To report the toxicity profile of high-dose-rate (HDR)-brachytherapy (BT) as monotherapy in a Human Investigation Committee-approved study consisting of a single implant and two fractions (12 Gy Multiplication-Sign 2) for a total dose of 24 Gy, delivered within 1 day. The dose was subsequently increased to 27 Gy (13.5 Gy Multiplication-Sign 2) delivered in 1 day. We report the acute and early chronic genitourinary and gastrointestinal toxicity. Methods and Materials: A total of 173 patients were treated between December 2005 and July 2010. However, only the first 100 were part of the IRB-approved study and out of these, only 94 had a minimal follow-up of 6 months, representing the study population for this preliminary report. All patients had clinical Stage T2b or less (American Joint Committee on Cancer, 5th edition), Gleason score 6-7 (3+4), and prostate-specific antigen level of {<=}12 ng/mL. Ultrasound-guided HDR-BT with real-time dosimetry was used. The prescription dose was 24 Gy for the first 50 patients and 27 Gy thereafter. The dosimetric goals and constraints were the same for the two dose groups. Toxicity was scored using the National Cancer Institute Common Terminology Criteria for Adverse Events, version 3. The highest toxicity scores encountered at any point during follow-up are reported. Results: The median follow-up was 17 months (range, 6-40.5). Most patients had Grade 0-1 acute toxicity. The Grade 2 acute genitourinary toxicity was mainly frequency/urgency (13%), dysuria (5%), hematuria, and dribbling/hesitancy (2%). None of the patients required a Foley catheter at any time; however, 8% of the patients experienced transient Grade 1 diarrhea. No other acute gastrointestinal toxicities were found. The most common chronic toxicity was Grade 2 urinary frequency/urgency in 16% of patients followed by dysuria in 4% of patients; 2 patients had Grade 2 rectal bleeding and 1 had Grade 4, requiring laser treatment. Conclusions: Favorable

  7. Global Geologic Mapping of Io: Preliminary Results

    Science.gov (United States)

    Williams, David A.; Keszthelyi, L. P.; Crown, D. A.; Geissler, P. E.; Schenk, P. M.; Yff, Jessica; Jaeger, W. L.; Rathbun, J. A.

    2008-01-01

    A new global geologic map of Jupiter's volcanic moon, Io is being prepared, with the focus being on completion of a draft map by July 2008. Here initial results of the mapping are reported: a preliminary distribution of material units in terms of areas and a visual representation. Additionally, the mapping hopes to address some of the problems in Io geology. Thus far it has been discovered that Io's surface is dominated by plains material, thought to consist of Io's silicate crust covered by pyroclastic deposits and lava flows of silicate and sulfur-bearing composition. Many plains areas contain flow fields that cannot be mapped separately due to a lack of resolution or modification by alteration processes. Discrete lava flows and flow fields are the next most abundant unit, with bright (sulfur?) flows in greater abundance than dark (silicate?) flows. The source of most of Io's heat flow, the paterae, are the least abundant unit in terms of areal extent.Upon completion of the draft map for peer review, it will be used to investigate several specific questions about the geological evolution of Io that previously could not be well addressed, including: comparison of the areas versus the heights of Ionian mountains to assess their stability and evolution; correlation and comparison of Galileo Near-Infrared Mapping Spectrometer and Photopolarimeter-Radiometer hot spot locations with the mapped location of dark versus bright lava flows and patera floors to assess any variations in the types of sources for Io's active volcanism; and the creation of a global inventory of the areal coverage of dark and bright laval flows to assess the relative importance of sulfur versus silicate volcanism in resurfacing Io, and to assess whether there are regional concentrations of either style of volcanism that may have implications on interior processes.

  8. Salvage high-dose-rate brachytherapy for local prostate cancer recurrence after radical radiotherapy

    Directory of Open Access Journals (Sweden)

    V. A. Solodkiy

    2016-01-01

    Full Text Available Studies salvage interstitial radiation therapy for recurrent prostate cancer, launched at the end of the XX century. In recent years, more and more attention is paid to high-dose-rate brachytherapy (HDR-BT as a method of treating local recurrence.The purpose of research – preliminary clinical results of salvage high-dose-rate brachytherapy applied in cases of suspected local recurrence or of residual tumour after radiotherapy.Preliminary findings indicate the possibility of using HDR-BT, achieving local tumor control with low genitourinary toxicity.

  9. Tellurium in active volcanic environments: Preliminary results

    Science.gov (United States)

    Milazzo, Silvia; Calabrese, Sergio; D'Alessandro, Walter; Brusca, Lorenzo; Bellomo, Sergio; Parello, Francesco

    2014-05-01

    Tellurium is a toxic metalloid and, according to the Goldschmidt classification, a chalcophile element. In the last years its commercial importance has considerably increased because of its wide use in solar cells, thermoelectric and electronic devices of the last generation. Despite such large use, scientific knowledge about volcanogenic tellurium is very poor. Few previous authors report result of tellurium concentrations in volcanic plume, among with other trace metals. They recognize this element as volatile, concluding that volcanic gases and sulfur deposits are usually enriched with tellurium. Here, we present some results on tellurium concentrations in volcanic emissions (plume, fumaroles, ash leachates) and in environmental matrices (soils and plants) affected by volcanic emissions and/or deposition. Samples were collected at Etna and Vulcano (Italy), Turrialba (Costa Rica), Miyakejima, Aso, Asama (Japan), Mutnovsky (Kamchatka) at the crater rims by using common filtration techniques for aerosols (polytetrafluoroethylene filters). Filters were both eluted with Millipore water and acid microwave digested, and analyzed by inductively coupled plasma mass spectrometry (ICP-MS). Volcanic ashes emitted during explosive events on Etna and Copahue (Argentina) were analyzed for tellurium bulk composition and after leaching experiments to evaluate the soluble fraction of tellurium. Soils and leaves of vegetation were also sampled close to active volcanic vents (Etna, Vulcano, Nisyros, Nyiragongo, Turrialba, Gorely and Masaya) and investigated for tellurium contents. Preliminary results showed very high enrichments of tellurium in volcanic emissions comparing with other volatile elements like mercury, arsenic, thallium and bismuth. This suggests a primary transport in the volatile phase, probably in gaseous form (as also suggested by recent studies) and/or as soluble salts (halides and/or sulfates) adsorbed on the surface of particulate particles and ashes. First

  10. Nonmelanoma skin cancer treated with electronic brachytherapy: results at 1 year.

    Science.gov (United States)

    Bhatnagar, Ajay

    2013-01-01

    We report clinical outcomes at 1 year or more after high-dose-rate (HDR) electronic brachytherapy (EBT) using surface applicators for the treatment of nonmelanoma skin cancer (NMSC). From July 2009 to April 2012, 122 patients with 171 NMSC lesions were treated with EBT to a dose of 40Gy in eight fractions, delivered twice weekly. At followup, patients were assessed for acute and late toxicities, cosmesis, and local control. Treatment of 171 lesions was completed in 122 patients with a mean age 73 years. There have been no recurrences to date with a mean followup of 10 months (range, 1-28 months). Followup data at 1 year or more were available for 46 lesions in 42 patients. Hypopigmentation (all Grade 1) was present in 5 (10.9%) of 46 lesions at 1 year. Other late effects at 1 year included dry desquamation, alopecia, and rash dermatitis, which occurred in 1 (2.2%), 1 (2.2%), and 3 (6.5%) of 46 lesions, respectively. No Grade 3 or higher adverse events were observed at any time point. Cosmesis was evaluated at 1 year for 42 of 46 lesions and was excellent for 39 (92.9%) and good for 3 (7.1%) of the 42 evaluable lesions. Treatment of NMSC with HDR EBT using surface applicators was effective with no recurrences, good to excellent cosmesis, and acceptable toxicities at 1 year or more after treatment. HDR EBT provides a convenient nonsurgical treatment option for NMSC patients. Copyright © 2013 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

  11. Propellant Nonlinear Constitutive Theory Extension: Preliminary Results.

    Science.gov (United States)

    1983-08-01

    r) dr f1 dr 0 *where: u : stress e: strain E(t) = relaxation modulus ( PRONY series representation using a matrix solution for curve fitting data...series of unaxial tests were conducted with two materials - a PEAN and an HTPB propellant. The data was fit to each of the nonlinear theories.* Then the...PRELIMINARY STUDY Generally speaking, solid propellants may be considered as lightly cross- linked long-chain polymers , highly filled with coarse solid

  12. Archaeogeophysical investigations in Tiwanaku: preliminary results

    Science.gov (United States)

    Masini, Nicola; Sileo, Maria; Lasaponara, Rosa; Leucci, Giovanni; Orefici, Giuseppe; Rizzo, Enzo

    2017-04-01

    -1450) Tiwanaku was characterized by the resurgence of regional identities and polities In spite of the rich archaeological record numerous issues, related to the function and the extension of Tiwanaku, need to be investigated especially in the monumental core which includes the pyramid of Akapana, and other ceremonial places such Kalasasaya, Putuni and Kantatallita. To this aims some geophysical investigations were performed in 2009 and 2014 in the context of multidisciplinary research including the use of satellite remote sensing [8]. This paper deals with the discussion of preliminary results of geomagnetic and GPR investigations, some of which have been verified by trial archaeological excavations which have unearthed some buried structures, improving the knowledge of the ceremonial areas of Tiwanaku. References [1] Lasaponara R., Leucci G., Masini N., Persico R., Scardozzi G., Towards an operative use of remote sensing for exploring the past using satellite data: The case study of Hierapolis (Turkey), Remote sensing of Environment, 174 (2016) : 148-164, doi:10.1016/j.rse.2015.12.016 [2] Masini N., Lasaponara R., Rizzo E., Orefici G. 2012. Integrated Remote Sensing Approach in Cahuachi (Peru): Studies and Results of the ITACA Mission (2007-2010), In: Lasaponara R., Masini N. (Eds) 2012, Satellite Remote Sensing: a new tool for Archaeology, Springer, Verlag Berlin Heidelberg, ISBN 978-90-481-8800-0, doi: 10.1007/978-90-481-8801-7_14; pp. 307-344 [3] Rizzo E., Masini N., Lasaponara R., Orefici G. 2010, ArchaeoGeophysical methods in the Templo del Escalonado (Cahuachi, Nasca, Perù), Near Surface Geophysics 8 (5), 433-439, doi:10.3997/1873-0604.2010030 [4] Masini N., Rizzo E., Lasaponara R., and Orefici G. 2008, Integrated remote sensing techniques for the detection of buried archaeological adobe structures: preliminary results in Cahuachi (Peru), Advances in Geosciences, 19, 75-82 [5] Lasaponara R., Leucci G., Masini N., Persico R. 2014. Investigating archaeological looting

  13. Quality assurance in MR image guided adaptive brachytherapy for cervical cancer: Final results of the EMBRACE study dummy run

    DEFF Research Database (Denmark)

    Kirisits, Christian; Federico, Mario; Nkiwane, Karen

    2015-01-01

    PURPOSE: Upfront quality assurance (QA) is considered essential when starting a multicenter clinical trial in radiotherapy. Despite the long experience gained for external beam radiotherapy (EBRT) trials, there are only limited audit QA methods for brachytherapy (BT) and none include the specific....... A second dummy run was required in case of major deviations (score 7) for any item. RESULTS: Overall 27/30 centers passed the dummy run. 16 centers had to repeat the dummy run in order to clarify major inconsistencies to the protocol. The most pronounced variations were related to contouring for both EBRT...... and BT. Centers with experience in IGABT (>30 cases) had better performance as compared to centers with limited experience. CONCLUSION: The comprehensive dummy run designed for the EMBRACE trial has been a feasible tool for QA in IGABT of cervix cancer. It should be considered for future IGABT trials...

  14. High-dose-rate interstitial brachytherapy for T1-T2-stage penile carcinoma: short-term results.

    Science.gov (United States)

    Sharma, Daya Nand; Joshi, Nikhil P; Gandhi, Ajeet Kumar; Haresh, Kunhi P; Gupta, Subhash; Julka, Pramod Kumar; Rath, Goura Kisor

    2014-01-01

    Interstitial brachytherapy (IBT) is a preferred treatment option over partial penectomy in selected patients with T1-T2-stage penile carcinoma because of its organ preservation ability. Literature is mostly based on the use of low-dose-rate IBT, and experience with high-dose-rate (HDR) IBT is extremely limited. We studied the role of HDR-IBT alone in patients with T1-T2-stage penile carcinoma. Between April 2010 and July 2013, 14 patients with T1-T2-stage penile carcinoma were treated with HDR-IBT at our center. Size of the primary lesion ranged from 1.5 to 4.0cm. A two-to-four-plane free-hand implant was performed using plastic catheters. The prescribed dose of HDR-IBT was 42-51Gy in 14-17 fractions using twice-a-day fractionation schedule. Patients were followed up regularly for assessment of local control, survival, toxicity, and sexual function. At a median followup of 22 months, 2 patients developed recurrent disease at locoregional site. The 3-year overall survival was 83% with penis preservation rate of 93%. All patients developed acute Grade III skin toxicity that healed during 6-8-weeks time. Urethral stenosis and soft tissue necrosis was not seen in any of the patients. A total of 4 patients experienced mild asymptomatic fibrosis in the implanted area. Around 10 patients had satisfactory sexual function status at the last followup visit. Although it was a small sample size, our results have demonstrated excellent local control rate and acceptable toxicity with HDR-IBT in patients with T1-T2-stage penile carcinoma. Copyright © 2014 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

  15. New era of electronic brachytherapy.

    Science.gov (United States)

    Ramachandran, Prabhakar

    2017-04-28

    Traditional brachytherapy refers to the placement of radioactive sources on or inside the cancer tissues. Based on the type of sources, brachytherapy can be classified as radionuclide and electronic brachytherapy. Electronic brachytherapy uses miniaturized X-ray sources instead of radionuclides to deliver high doses of radiation. The advantages of electronic brachytherapy include low dose to organs at risk, reduced dose to treating staff, no leakage radiation in off state, less shielding, and no radioactive waste. Most of these systems operate between 50 and 100 kVp and are widely used in the treatment of skin cancer. Intrabeam, Xoft and Papillon systems are also used in the treatment of intra-operative radiotherapy to breast in addition to other treatment sites. The rapid fall-off in the dose due to its low energy is a highly desirable property in brachytherapy and results in a reduced dose to the surrounding normal tissues compared to the Ir-192 source. The Xoft Axxent brachytherapy system uses a 2.25 mm miniaturized X-ray tube and the source almost mimics the high dose rate Ir-192 source in terms of dose rate and it is the only electronic brachytherapy system specifically used in the treatment of cervical cancers. One of the limiting factors that impede the use of electronic brachytherapy for interstitial application is the source dimension. However, it is highly anticipated that the design of miniaturized X-ray tube closer to the dimension of an Ir-192 wire is not too far away, and the new era of electronic brachytherapy has just begun.

  16. New era of electronic brachytherapy

    Science.gov (United States)

    Ramachandran, Prabhakar

    2017-01-01

    Traditional brachytherapy refers to the placement of radioactive sources on or inside the cancer tissues. Based on the type of sources, brachytherapy can be classified as radionuclide and electronic brachytherapy. Electronic brachytherapy uses miniaturized X-ray sources instead of radionuclides to deliver high doses of radiation. The advantages of electronic brachytherapy include low dose to organs at risk, reduced dose to treating staff, no leakage radiation in off state, less shielding, and no radioactive waste. Most of these systems operate between 50 and 100 kVp and are widely used in the treatment of skin cancer. Intrabeam, Xoft and Papillon systems are also used in the treatment of intra-operative radiotherapy to breast in addition to other treatment sites. The rapid fall-off in the dose due to its low energy is a highly desirable property in brachytherapy and results in a reduced dose to the surrounding normal tissues compared to the Ir-192 source. The Xoft Axxent brachytherapy system uses a 2.25 mm miniaturized X-ray tube and the source almost mimics the high dose rate Ir-192 source in terms of dose rate and it is the only electronic brachytherapy system specifically used in the treatment of cervical cancers. One of the limiting factors that impede the use of electronic brachytherapy for interstitial application is the source dimension. However, it is highly anticipated that the design of miniaturized X-ray tube closer to the dimension of an Ir-192 wire is not too far away, and the new era of electronic brachytherapy has just begun. PMID:28529679

  17. Brachytherapy in France in 2002: results of the ESTRO-PCBE questionnaire; La curietherapie en France en 2002: resultats de l'enquete PCBE de l'ESTRO

    Energy Technology Data Exchange (ETDEWEB)

    Peiffert, D. [Centre Alexis-Vautrin, Dept. de Radiotherapie, 54 - Vandoeuvre-les-Nancy (France); Mazeron, J.J. [Hopital de la Pitie-Salpetriere, Centre des Tumeurs, 75 - Paris (France); Guedea, F. [Institut Catala d' Oncologia Idibell, L' hospitalet del Llobregat, Barcelone (Spain); Nisin, R. [ESTRO office, Bruxelles (Belgium)

    2007-05-15

    The authors report the results of the Patterns of Care for Brachytherapy in Europe (PCBE) throughout France. Responses were obtained for 91% of the Radiation Oncology departments, which have declared using brachytherapy for 67, and gave detailed data for 49 ones. The equipments and treated tumours were recorded. LDR brachytherapy remained the most often used (53.5 ), followed by HDR (28%). PDR represented 5.5% and permanent implants 11%. The authors discuss the development of new equipment, with an aggregation of the structures, and an increase of the PDR and prostate implants use. (authors)

  18. Preliminary results of steel containment vessel model test

    Energy Technology Data Exchange (ETDEWEB)

    Matsumoto, T.; Komine, K.; Arai, S. [Nuclear Power Engineering Corp., Tokyo (Japan)] [and others

    1997-04-01

    A high pressure test of a mixed-scaled model (1:10 in geometry and 1:4 in shell thickness) of a steel containment vessel (SCV), representing an improved boiling water reactor (BWR) Mark II containment, was conducted on December 11-12, 1996 at Sandia National Laboratories. This paper describes the preliminary results of the high pressure test. In addition, the preliminary post-test measurement data and the preliminary comparison of test data with pretest analysis predictions are also presented.

  19. Preliminary results of steel containment vessel model test

    Energy Technology Data Exchange (ETDEWEB)

    Luk, V.K.; Hessheimer, M.F. [Sandia National Labs., Albuquerque, NM (United States); Matsumoto, T.; Komine, K.; Arai, S. [Nuclear Power Engineering Corp., Tokyo (Japan); Costello, J.F. [Nuclear Regulatory Commission, Washington, DC (United States)

    1998-04-01

    A high pressure test of a mixed-scaled model (1:10 in geometry and 1:4 in shell thickness) of a steel containment vessel (SCV), representing an improved boiling water reactor (BWR) Mark II containment, was conducted on December 11--12, 1996 at Sandia National Laboratories. This paper describes the preliminary results of the high pressure test. In addition, the preliminary post-test measurement data and the preliminary comparison of test data with pretest analysis predictions are also presented.

  20. Retrospective study of the local control and the cosmetic result of 147 face carcinomas after interstitial brachytherapy; Etude retrospective du controle local et du resultat cosmetique de 147 carcinomes de la face apres curietherapie interstitielle

    Energy Technology Data Exchange (ETDEWEB)

    Ducassou, A.; David, I.; Bonnet, J.; Delannes, M. [Institut Claudius-Regaud, Service de Radiotherapie, 31 - Toulouse (France)

    2009-10-15

    The purpose was to evaluate retrospectively the local control rate and the cosmetic results for patients that received an interstitial brachytherapy for a base or spino-cellular carcinoma of face orifices areas. The interstitial brachytherapy by iridium 192 is an excellent alternative to surgery in the skin carcinomas of the face, as well at the level of local control as the cosmetic and functional results. (N.C.)

  1. A Quantum Inspired GVNS: Some Preliminary Results.

    Science.gov (United States)

    Papalitsas, Christos; Karakostas, Panayiotis; Kastampolidou, Kalliopi

    2017-01-01

    GVNS is a well known and widely used metaheuristic for solving efficiently many NP-Hard Combinatorial Optimization problems. In this paper, the qGVNS, which is a new quantum inspired variant of GVNS, is being introduced. This variant differs in terms of the perturbation phase because it achieves the shaking moves by adopting quantum computing principles. The functionality and efficiency of qGVNS have been tested using a comparative study (compared with the equivalent GVNS results) in selected TSPLib instances, both in first and best improvement.

  2. Medical Radioisotope Data Survey: 2002 Preliminary Results

    Energy Technology Data Exchange (ETDEWEB)

    Siciliano, Edward R.

    2004-06-23

    A limited, but accurate amount of detailed information about the radioactive isotopes used in the U.S. for medical procedures was collected from a local hospital and from a recent report on the U.S. Radiopharmaceutical Markets. These data included the total number of procedures, the specific types of procedures, the specific radioisotopes used in these procedures, and the dosage administered per procedure. The information from these sources was compiled, assessed, pruned, and then merged into a single, comprehensive and consistent set of results presented in this report. (PIET-43471-TM-197)

  3. PEDESTRIAN PATHFINDING IN URBAN ENVIRONMENTS: PRELIMINARY RESULTS

    Directory of Open Access Journals (Sweden)

    G. López-Pazos

    2017-12-01

    Full Text Available With the rise of urban population, many initiatives are focused upon the smart city concept, in which mobility of citizens arises as one of the main components. Updated and detailed spatial information of outdoor environments is needed to accurate path planning for pedestrians, especially for people with reduced mobility, in which physical barriers should be considered. This work presents a methodology to use point clouds to direct path planning. The starting point is a classified point cloud in which ground elements have been previously classified as roads, sidewalks, crosswalks, curbs and stairs. The remaining points compose the obstacle class. The methodology starts by individualizing ground elements and simplifying them into representative points, which are used as nodes in the graph creation. The region of influence of obstacles is used to refine the graph. Edges of the graph are weighted according to distance between nodes and according to their accessibility for wheelchairs. As a result, we obtain a very accurate graph representing the as-built environment. The methodology has been tested in a couple of real case studies and Dijkstra algorithm was used to pathfinding. The resulting paths represent the optimal according to motor skills and safety.

  4. Pedestrian Pathfinding in Urban Environments: Preliminary Results

    Science.gov (United States)

    López-Pazos, G.; Balado, J.; Díaz-Vilariño, L.; Arias, P.; Scaioni, M.

    2017-12-01

    With the rise of urban population, many initiatives are focused upon the smart city concept, in which mobility of citizens arises as one of the main components. Updated and detailed spatial information of outdoor environments is needed to accurate path planning for pedestrians, especially for people with reduced mobility, in which physical barriers should be considered. This work presents a methodology to use point clouds to direct path planning. The starting point is a classified point cloud in which ground elements have been previously classified as roads, sidewalks, crosswalks, curbs and stairs. The remaining points compose the obstacle class. The methodology starts by individualizing ground elements and simplifying them into representative points, which are used as nodes in the graph creation. The region of influence of obstacles is used to refine the graph. Edges of the graph are weighted according to distance between nodes and according to their accessibility for wheelchairs. As a result, we obtain a very accurate graph representing the as-built environment. The methodology has been tested in a couple of real case studies and Dijkstra algorithm was used to pathfinding. The resulting paths represent the optimal according to motor skills and safety.

  5. The GMAO ADVAR System: Preliminary Results

    Science.gov (United States)

    Todling, Ricardo

    2009-01-01

    The Goddard Earth Observing System (GEOS-S) Data Assimilation System is now configurable to run strong constraint 4DVAR. The system combines the 4DVAR-capable Grid-point Statistical Interpolation analysis with the GEOS-S general circulation model and an early version of the tangent linear and adjoint models of the finite-volume hydrodynamics with simplified physics. The GMAO 4DVAR uses a Lanczos-based conjugate gradient algorithm in a nested resolution inner-loop setting. A range of tests and experiments will have been carried out by the time of the Symposium. Results on balance-related issues, resolution configuration, and choice of assimilation time window will be shown. A comparison with the Global Modeling and Assimilation Office (GMAO) 3DVAR and a discussion of future directions of development will also be presented.

  6. Preliminary Results from the FLAMINGOS Extragalactic Survey

    Science.gov (United States)

    Gonzalez, A.; Dey, A.; Eisenhardt, P. R. M.; Jannuzi, B.; Lin, Y.-T.; McKenzie, E.; Mohr, J. J.; Raines, S. N.; Stanford, S. A.; Stern, D.; Brown, M.; Elston, R. J.

    2004-05-01

    We present initial results from the FLAMINGOS Extragalactic Survey, a deep near-infrared imaging survey within the NOAO Deep Wide-Field Survey regions. This program is designed to study evolution of the galaxy and galaxy cluster populations out to z ˜2. The field locations are selected to provide extensive overlap with observations at other wavelengths, and the target depths of the survey are Ks=20.5 and J=22 (Vega). The final observations for the survey were obtained in May, and final data reduction and quality assessment are nearing completion. During this talk we describe the initial science being done with the data set, highlight upcoming work, and discuss planned coordination with other surveys within the NDWFS region. Specific emphasis will be placed upon identification of galaxy clusters at z>1.

  7. Computerized Script Training for Aphasia: Preliminary Results

    Science.gov (United States)

    Cherney, Leora R.; Halper, Anita S.; Holland, Audrey L.; Cole, Ron

    2009-01-01

    Purpose This article describes computer software that was developed specifically for training conversational scripts and illustrates its use with three individuals with aphasia. Methods Three participants with chronic aphasia (Broca’s, Wernicke’s and anomic) were assessed before and after nine weeks of a computer script training program. For each participant, three individualized scripts were developed, recorded on the software, and practiced sequentially at home. Weekly meetings with the speech-language pathologist occurred to monitor practice and assess progress. Baseline and post-treatment scripts were audio-taped, transcribed, and compared to the target scripts for content, grammatical productivity and rate of production of script-related words. Interviews with the person with aphasia and their significant other were conducted at the conclusion of treatment. Results All measures (content, grammatical productivity and rate of production of script-related words) improved for each participant on every script. Two participants gained more than five points on the Aphasia Quotient of the Western Aphasia Battery. Five positive themes were consistently identified from the exit interviews - increased verbal communication, improvements in other modalities and situations, communication changes noticed by others, increased confidence, and satisfaction with the software. Conclusion Computer-based script training potentially may be an effective intervention for persons with chronic aphasia. PMID:18230811

  8. SAPCE CAP linkage methodology and preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Choo, Yeon Joon; Hong, Soon Joon; Lee, Byung Chul [FNC Tech., Seoul (Korea, Republic of); Ha, Sang Jun; Choi, Hoon [KHNP Centeral research institute, Daejeon (Korea, Republic of); Lee, Tae Beom [KEPCO Nuclear Fuel, Daejeon (Korea, Republic of)

    2012-10-15

    As a part of the development project of the domestic design code for licensing purposes of pressurized water reactors, the SPACE (Safety and Performance Calculation Code) and CAP (Containment Analysis Package) code are under development in Korea. The SPACE code has applicability to analysis of the system behavior of nuclear power plant under the various accident conditions. On the order hand, CAP code is focused on the calculation of pressure and temperature of containment compartments. Two codes, of course, were designed to deal with the general thermal hydraulic problems also. In other to evaluate conservatively the performance of ECCS equipment; minimum containment back pressure is conservative, the containment pressure is important boundary condition. In this respect, linking two codes; RELAP5/MOD3 for system code and CONTEMPT4/MOD5 for containment code was tried to calculate the minimum containment back pressure in the framework of KREM (KEPRI Realistic Evaluation Methodology). These results are used in FSAR of Kori3/4. For the above same purpose, linking the SPACE and CAP code has tried based on KREM in this research. The target plant is the Shinkori 3/4 nuclear plant; APR1400 type. This plant has quite different design concept from other operating plants such as OPR1000 and WH 3 loop plant. Major feature of APR1400 is that RWST (Refueling Water Storage Tank) is located in plant.

  9. Asymmetrical soft palate cleft repair: preliminary results.

    Science.gov (United States)

    Bütow, K-W; Engelbrecht, H; Naidoo, S

    2014-06-01

    The reconstructions of the asymmetrical soft palate cleft is a surgical challenge when it comes to achieving symmetry and optimal soft palate muscular function. Three different versions of the intravelar veloplasty have been used: the intravelar veloplasty (1969) (type I), the modification according to anatomical defects (1991) (type II), and the modification using part of Sommerlad's technique and part of Ivanov's technique (2008) (type III). The perioperative outcomes of the type II and type III intravelar veloplasty were assessed and compared in asymmetrical cleft cases. Two hundred and seventy-seven soft palate clefts were reconstructed: 153 type II and 124 type III. Of these, 49 were asymmetrical (17.7%); 23 underwent the type II procedure and 26 the type III procedure. Of the type II procedure cases, 30.4% remained asymmetrical postoperatively compared to 3.8% of the type III cases. The uvula appeared subjectively atrophic in 47.8% of the type II cases and in 7.7% of type III cases. Oro-nasal fistula occurred in 13.0% of the type II cases and 3.8% of the type III cases. Speech results will only be assessed after 4 years of age. The type III modified intravelar veloplasty has had a major beneficial impact on patients who had an asymmetrical soft palate cleft. Copyright © 2014. Published by Elsevier Ltd.

  10. Laser treatment of stretch marks: preliminary results

    Science.gov (United States)

    Longo, Leonardo; Piccinetti, A. L.; Monache, G. D.; Botta, G.; Mancini, S.

    2000-06-01

    The best treatment of these stretch mark is still unknown. Some authors proposed the treatment with flash-lamp-pumped dye laser 585 nm, with fluence over 8 J/cm2. Reviewing our experiences on no-surgical effects of lasers in the various phases of the wound healing, including the re- epithelization, we would like to apply the no-surgical laser therapy treating the stretch marks of breast, abdomen and lumbo-sacral region. The goal is to inhibit the fibrous tissue metabolism, encouraging the destruction of the collagen fibers with inflammatory mechanism, and increasing the reconstitution of the superficial dermis layers. We treated five cases of stretch marks in women 22-35 years old, since May 1999, with a cycle of applications of double lasers, 511 and 577 nm, with energy of 20 Joule for spot, respecting the maximum thermal relaxation times of the skin. We waited two weeks interval between the applications. Results obtained after five applications are very positive, and we are encouraged to continue this experimentation.

  11. Phase I/II prospective trial of cancer-specific imaging using ultrasound spectrum analysis tissue-type imaging to guide dose-painting prostate brachytherapy.

    Science.gov (United States)

    Ennis, Ronald D; Quinn, S Aidan; Trichter, Frieda; Ryemon, Shannon; Jain, Anudh; Saigal, Kunal; Chandrashekhar, Sarayu; Romas, Nicholas A; Feleppa, Ernest J

    2015-01-01

    To assess the technical feasibility, toxicity, dosimetry, and preliminary efficacy of dose-painting brachytherapy guided by ultrasound spectrum analysis tissue-type imaging (TTI) in low-risk, localized prostate cancer. Fourteen men with prostate cancer who were candidates for brachytherapy as sole treatment were prospectively enrolled. Treatment planning goal was to escalate the tumor dose to 200% with a modest de-escalation of dose to remaining prostate compared with our standard. Primary end points included technical feasibility of TTI-guided brachytherapy and equivalent or better toxicity compared with standard brachytherapy. Secondary end points included dose escalation to tumor regions and de-escalated dose to nontumor regions on the preimplant plan, negative prostate biopsy at 2 years, and freedom from biochemical failure. Thirteen of fourteen men successfully completed the TTI-guided brachytherapy procedure for a feasibility rate of 93%. A software malfunction resulted in switching one patient from TTI-guided to standard brachytherapy. An average of 2.7 foci per patient was demonstrated and treated with an escalated dose. Dosimetric goals on preplan were achieved. One patient expired from unrelated causes 65 days after brachytherapy. Toxicity was at least as low as standard brachytherapy. Two-year prostate biopsies were obtained from six men; five (83%) were definitively negative, one showed evidence of disease with treatment effect, and none were positive. No patients experienced biochemical recurrence after a median followup of 31.5 (24-52) months. We have demonstrated that TTI-guided dose-painting prostate brachytherapy is technically feasible and results in clinical outcomes that are encouraging in terms of low toxicity and successful biochemical disease control. Copyright © 2015 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

  12. Bahamas Optical Turbulence Exercise (BOTEX): preliminary results

    Science.gov (United States)

    Hou, Weilin; Jorosz, Ewa; Dalgleish, Fraser; Nootz, Gero; Woods, Sarah; Weidemann, Alan D.; Goode, Wesley; Vuorenkoski, Anni; Metzger, B.; Ramos, B.

    2012-06-01

    patterns are examined, using high speed camera recordings (300 to 1200 fps), in association with measured turbulence structures. Initial results confirmed our hypothesis that turbulence impacted optical transmissions. They also showed that more research will be needed to better quantify and mitigate such effects, especially for the U.S. Navy's next generation EO systems, including active imaging, lidar and optical communications.

  13. Chemoradiation in cervical cancer with cisplatin and high-dose rate brachytherapy combined with external beam radiotherapy. Results of a phase-II study

    Energy Technology Data Exchange (ETDEWEB)

    Strauss, H.G.; Laban, C.; Puschmann, D.; Koelbl, H. [Dept. of Gynecology, Martin-Luther Univ. Halle-Wittenberg (Germany); Kuhnt, T.; Pigorsch, S.; Dunst, J.; Haensgen, G. [Dept. of Radiotherapy, Martin-Luther Univ. Halle-Wittenberg (Germany)

    2002-07-01

    Background: In 1999, five randomized studies demonstrated that chemoradiation with cisplatin and low-dose rate (LDR) brachytherapy has a benefit in locally advanced cervical cancer and for surgically treated patients in high-risk situations. We evaluated the safety and efficacy of concomitant chemoradiation with cisplatin and high-dose rate (HDR) brachytherapy in patients with cervical cancer. Patients and Method: 27 patients were included in our phase-II trial: 13 locally advanced cases (group A) and 14 adjuvant-therapy patients in high-risk situations (group B). A definitive radiotherapy was performed with 25 fractions of external beam therapy (1.8 Gy per fraction/middle shielded after eleven fractions). Brachytherapy was delivered at HDR schedules with 7 Gy in point A per fraction (total dose 35 Gy) in FIGO Stages IIB-IIIB. The total dose of external and brachytherapy was 70 Gy in point A and 52-54 Gy in point B. All patients in stage IVA were treated without brachytherapy. Adjuvant radiotherapy was performed with external beam radiotherapy of the pelvis with 1.8 Gy single-dose up to 50.4 Gy. Brachytherapy was delivered at HDR schedules with two fractions of 5 Gy only in patients with tumor-positive margins or tumor involvement of the upper vagina. The chemotherapeutic treatment schedule provided six courses of cisplatin 40 mg/m{sup 2} weekly recommended in the randomized studies GOG-120 and -123. Results: A total of 18/27 patients (66.7%) completed all six courses of chemotherapy. Discontinuation of radiotherapy due to therapy-related morbidity was not necessary in the whole study group. G3 leukopenia (29.6%) was the only relevant acute toxicity. There were no differences in toxicity between group A and B. Serious late morbidity occurred in 2/27 patients (7.4%). 12/13 patients (92.3%) with IIB-IVA cervical cancer showed a complete response (CR). 13/14 adjuvant cases (92.8%) are free of recurrence (median follow up: 19.1 months). Conclusion: Concomitant

  14. Californium-252 Brachytherapy Combined With External-Beam Radiotherapy for Cervical Cancer: Long-Term Treatment Results

    Energy Technology Data Exchange (ETDEWEB)

    Lei Xin; Qian Chengyuan; Qing Yi; Zhao Kewei; Yang Zhengzhou; Dai Nan; Zhong Zhaoyang; Tang Cheng; Li Zheng; Gu Xianqing; Zhou Qian; Feng Yan; Xiong Yanli; Shan Jinlu [Cancer Center, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing (China); Wang Dong, E-mail: dongwang64@hotmail.com [Cancer Center, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing (China)

    2011-12-01

    Purpose: To observe, by retrospective analysis, the curative effects and complications due to californium-252 ({sup 252}Cf) neutron intracavitary brachytherapy (ICBT) combined with external-beam radiotherapy (EBRT) in the treatment of cervical cancer. Methods and Materials: From February 1999 to December 2007, 696 patients with cervical cancer (Stages IB to IIIB) were treated with {sup 252}Cf-ICBT in combination of EBRT. Of all, 31 patients were at Stage IB, 104 at IIA, 363 at IIB, 64 at IIIA, and 134 at IIIB. Californium-252 ICBT was delivered at 7-12 Gy per insertion per week, with a total dose of 29-45 Gy to reference point A in three to five insertions. The whole pelvic cavity was treated with 8-MV X-ray external irradiation at 2 Gy per fraction, four times per week. After 16-38 Gy of external irradiation, the center of the whole pelvic field was blocked with a 4-cm-wide lead shield, with a total external irradiation dose of 44-56 Gy. The total treatment course was 5 to 6 weeks. Results: Overall survival rate at 3 and 5 years for all patients was 76.0% and 64.9%, respectively. Disease-free 3- and 5-year survival rates of patients were 71.2% and 58.4%, respectively. Late complications included vaginal contracture and adhesion, radiation proctitis, radiation cystitis, and inflammatory bowel, which accounted for 5.8%, 7.1%, 6.2%, and 4.9%, respectively. Univariate analysis results showed significant correlation of stage, age, histopathologic grade, and lymph node status with overall survival. Cox multiple regression analysis showed that the independent variables were stage, histopathologic grade, tumor size, and lymphatic metastasis in all patients. Conclusion: Results of this series suggest that the combined use of {sup 252}Cf-ICBT with EBRT is an effective method for treatment of cervical cancer.

  15. High-dose-rate brachytherapy as a monotherapy for prostate cancer--Single-institution results of the extreme fractionation regimen.

    Science.gov (United States)

    Kukiełka, Andrzej Marek; Dąbrowski, Tomasz; Walasek, Tomasz; Olchawa, Agnieszka; Kudzia, Roksana; Dybek, Dorota

    2015-01-01

    We report a single-institution retrospective analysis of the outcomes, disease control, and toxicity of high-dose-rate (HDR) brachytherapy used as the only treatment modality (monotherapy) for localized prostate cancer. Between 2006 and 2012, 77 patients with diagnosed prostate cancer were treated with HDR brachytherapy as a monotherapy. The prescribed dose was 45 Gy in three separate implants 21 days apart, with single fraction per implant. Of the 77 patients, 67 (87%) received hormonal therapy. Prostate-specific antigen failure was defined according to Phoenix consensus, as nadir + 2 ng/mL. Toxicity was scored according to Common Terminology Criteria for Adverse Events, version 4.03. The median followup time was 57 months (4.75 years). The 5-year actuarial overall survival was 98.7%, biochemical control 96.7%, local control 96.9%, and metastasis-free survival 98.4%. Younger age at the beginning of brachytherapy predicted the onset of bounce phenomenon. There were no Grade 3 or higher acute toxicities detected, and Grade 2 genitourinary acute toxicity developed in 19 patients (24.6%). There were no Grade 2 gastrointestinal complications. No Grade 4 or 5 late toxicity was detected. There were also no Grade 3 gastrointestinal toxicities detected. One patient (1.3%) underwent transurethral resection of the prostate because of Grade 3 urethral stenosis and urinary retention. A total of 26 patients (33.8%) developed Grade 2 late toxicity. HDR brachytherapy as monotherapy for localized prostate cancer was feasible, effective, and had acceptable toxicity profile. Copyright © 2015 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

  16. Connecticut Transit (CTTRANSIT) Fuel Cell Transit Bus: Preliminary Evaluation Results

    Energy Technology Data Exchange (ETDEWEB)

    Chandler, K.; Eudy, L.

    2008-10-01

    This report provides preliminary results from a National Renewable Energy Laboratory evaluation of a protoptye fuel cell transit bus operating at Connecticut Transit in Hartford. Included are descriptions of the planned fuel cell bus demonstration and equipment; early results and agency experience are also provided.

  17. High-Dose-Rate Interstitial Brachytherapy as Monotherapy for Clinically Localized Prostate Cancer: Treatment Evolution and Mature Results

    Energy Technology Data Exchange (ETDEWEB)

    Zamboglou, Nikolaos [Department of Radiation Oncology, Klinikum Offenbach, Offenbach (Germany); Tselis, Nikolaos, E-mail: ntselis@hotmail.com [Department of Radiation Oncology, Klinikum Offenbach, Offenbach (Germany); Baltas, Dimos [Department of Medical Physics and Engineering, Klinikum Offenbach, Offenbach (Germany); Buhleier, Thomas [Department of Radiation Oncology, Klinikum Offenbach, Offenbach (Germany); Martin, Thomas [Department of Radiation Oncology, Klinikum Bremen-Mitte, Bremen (Germany); Milickovic, Natasa; Papaioannou, Sokratis [Department of Medical Physics and Engineering, Klinikum Offenbach, Offenbach (Germany); Ackermann, Hanns [Institute of Biostatistics, J.W. Goethe University of Frankfurt, Frankfurt (Germany); Tunn, Ulf W. [Department of Urology, Klinikum Offenbach, Offenbach (Germany)

    2013-03-01

    Purpose: To report the clinical outcome of high-dose-rate (HDR) interstitial (IRT) brachytherapy (BRT) as sole treatment (monotherapy) for clinically localized prostate cancer. Methods and Materials: Between January 2002 and December 2009, 718 consecutive patients with clinically localized prostate cancer were treated with transrectal ultrasound (TRUS)-guided HDR monotherapy. Three treatment protocols were applied; 141 patients received 38.0 Gy using one implant in 4 fractions of 9.5 Gy with computed tomography-based treatment planning; 351 patients received 38.0 Gy in 4 fractions of 9.5 Gy, using 2 implants (2 weeks apart) and intraoperative TRUS real-time treatment planning; and 226 patients received 34.5 Gy, using 3 single-fraction implants of 11.5 Gy (3 weeks apart) and intraoperative TRUS real-time treatment planning. Biochemical failure was defined according to the Phoenix consensus, and toxicity was evaluated using Common Toxicity Criteria for Adverse Events version 3. Results: The median follow-up time was 52.8 months. The 36-, 60-, and 96-month biochemical control and metastasis-free survival rates for the entire cohort were 97%, 94%, and 90% and 99%, 98%, and 97%, respectively. Toxicity was scored per event, with 5.4% acute grade 3 genitourinary and 0.2% acute grade 3 gastrointestinal toxicity. Late grade 3 genitourinary and gastrointestinal toxicities were 3.5% and 1.6%, respectively. Two patients developed grade 4 incontinence. No other instance of grade 4 or greater acute or late toxicity was reported. Conclusion: Our results confirm IRT-HDR-BRT is safe and effective as monotherapy for clinically localized prostate cancer.

  18. Bladder Function Preservation With Brachytherapy, External Beam Radiation Therapy, and Limited Surger in Bladder Cancer Patients: Long-Term Results

    Energy Technology Data Exchange (ETDEWEB)

    Aluwini, Shafak, E-mail: s.aluwini@erasmusmc.nl [Department of Radiation Oncology, Erasmus MC Cancer Institution, Rotterdam (Netherlands); Rooij, Peter H.E. van [Department of Radiation Oncology, Erasmus MC Cancer Institution, Rotterdam (Netherlands); Kirkels, Wim J.; Boormans, Joost L. [Department of Urology, Erasmus MC Cancer Institution, Rotterdam (Netherlands); Kolkman-Deurloo, Inger-Karina K.; Wijnmaalen, Arendjan [Department of Radiation Oncology, Erasmus MC Cancer Institution, Rotterdam (Netherlands)

    2014-03-01

    Purpose: To report long-term results of a bladder preservation strategy for muscle-invasive bladder cancer (MIBC) using external beam radiation therapy and brachytherapy/interstitial radiation therapy (IRT). Methods and Materials: Between May 1989 and October 2011, 192 selected patients with MIBC were treated with a combined regimen of preoperative external beam radiation therapy and subsequent surgical exploration with or without partial cystectomy and insertion of source carrier tubes for afterloading IRT using low dose rate and pulsed dose rate. Data for oncologic and functional outcomes were prospectively collected. The primary endpoints were local recurrence-free survival (LRFS), bladder function preservation survival, and salvage cystectomy-free survival. The endpoints were constructed according to the Kaplan-Meier method. Results: The mean follow-up period was 105.5 months. The LRFS rate was 80% and 73% at 5 and 10 years, respectively. Salvage cystectomy-free survival at 5 and 10 years was 93% and 85%. The 5- and 10-year overall survival rates were 65% and 46%, whereas cancer-specific survival at 5 and 10 years was 75% and 67%. The distant metastases-free survival rate was 76% and 69% at 5 and 10 years. Multivariate analysis revealed no independent predictors of LRFS. Radiation Therapy Oncology Group grade ≥3 late bladder and rectum toxicity were recorded in 11 patients (5.7%) and 2 patients (1%), respectively. Conclusions: A multimodality bladder-sparing regimen using IRT offers excellent long-term oncologic outcome in selected patients with MIBC. The late toxicity rate is low, and the majority of patients preserve their functional bladder.

  19. Protocol-based image-guided salvage brachytherapy. Early results in patients with local failure of prostate cancer after radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Lahmer, G.; Lotter, M.; Kreppner, S.; Fietkau, R.; Strnad, V. [University Hospital Erlangen (Germany). Dept. of Radiation Oncology

    2013-08-15

    Purpose: To assess the overall clinical outcome of protocol-based image-guided salvage pulsed-dose-rate brachytherapy for locally recurrent prostate cancer after radiotherapy failure particularly regarding feasibility and side effects. Patients and methods: Eighteen consecutive patients with locally recurrent prostate cancer (median age, 69 years) were treated during 2005-2011 with interstitial PDR brachytherapy (PDR-BT) as salvage brachytherapy after radiotherapy failure. The treatment schedule was PDR-BT two times with 30 Gy (pulse dose 0.6 Gy/h, 24 h per day) corresponding to a total dose of 60 Gy. Dose volume adaptation was performed with the aim of optimal coverage of the whole prostate (V{sub 100} > 95 %) simultaneously respecting the protocol-based dose volume constraints for the urethra (D{sub 0.1} {sub cc} < 130 %) and the rectum (D{sub 2} {sub cc} < 50-60 %) taking into account the previous radiation therapy. Local relapse after radiotherapy (external beam irradiation, brachytherapy with J-125 seeds or combination) was confirmed mostly via choline-PET and increased PSA levels. The primary endpoint was treatment-related late toxicities - particularly proctitis, anal incontinence, cystitis, urinary incontinence, urinary frequency/urgency, and urinary retention according to the Common Toxicity Criteria. The secondary endpoint was PSA-recurrence-free survival. Results: We registered urinary toxicities only. Grade 2 and grade 3 toxicities were observed in up to 11.1 % (2/18) and 16.7 % (3/18) of patients, respectively. The most frequent late-event grade 3 toxicity was urinary retention in 17 % (3/18) of patients. No late gastrointestinal side effects occurred. The biochemical PSA-recurrence-free survival probability at 3 years was 57.1 %. The overall survival at 3 years was 88.9 %; 22 % (4/18) of patients developed metastases. The median follow-up time for all patients after salvage BT was 21 months (range, 8-77 months). Conclusion: Salvage PDR-brachytherapy

  20. Intracranial ependymoma: long-term results in a series of 21 patients treated with stereotactic (125iodine brachytherapy.

    Directory of Open Access Journals (Sweden)

    Faycal El Majdoub

    Full Text Available BACKGROUND: We evaluated the long-term outcome in patients harboring intracranial ependymomas treated with interstitial brachytherapy (IBT. METHODS: Twenty-one patients (M/F = 9/12; median age: 29 years; range: 8-70 years, diagnosed with intracranial ependymoma (1 WHO I, 11 WHO II, 9 WHO III were treated with IBT using stereotactically implanted (125Iodine seeds between 1987 and 2010, either primarily, as adjuvant therapy following incomplete resection, or as salvage treatment upon tumor recurrence. Sixteen of 21 patients underwent microsurgical resection prior to IBT; in 5 patients, IBT was performed primarily after stereotactic biopsy for histological diagnosis. The cumulative tumor surface dose ranged from 50-65 Gy treating a median tumor volume of 3.6 ml (range, 0.3-11.6 ml. A median follow-up period of 105.3 months (range, 12.7-286.2 months was evaluated. RESULTS: Actuarial 2-, 5- and 10-years overall- and disease-specific survival rates after IBT were each 90% and 100% at all times for ependymomas WHO I/II, for anaplastic ependymomas WHO III 100%, 100%, 70% and 100%, 100%, 86%, respectively. The neurological status of seven patients improved, while there was no change in 12 and deterioration in 2 patients, respectively. Follow-up MR images disclosed a complete tumor remission in 3, a partial remission in 12 and a stable disease in 6 patients. Treatment-associated morbidity only occurred in a single patient. CONCLUSIONS: This study shows that stereotactic IBT for intracranial ependymomas is safe and can provide a high degree of local tumor control. Due to the low rate of side effects, IBT may evolve into an attractive alternative to microsurgery in ependymomas located in eloquent areas or as a salvage treatment.

  1. Preliminary Results of High-Energy Cosmic Ray Muons as ...

    Indian Academy of Sciences (India)

    We have constructed and installed (in Riyadh, Saudi Arabia, Rc =14.4 GV) a three-layer small (20 × 20 cm2) MultiWire Chamber (MWC) telescope to study cosmic ray variations and investigate their influence on various atmospheric and environmental processes. Preliminary results obtained from the developed detector are ...

  2. The friction of polymers around Tg,Tm : Preliminary results

    DEFF Research Database (Denmark)

    Sivebæk, Ion Marius; Samoilov, V N; Persson, B N J

    We present Molecular Dynamics calculations involving polymers of different lengths. Polymers with lengths from 20 to 1400 carbon atoms are considered. The systems are able to simulate friction between polymer surfaces and polymer against metal. The results we present are very preliminary...

  3. 75 FR 41143 - Silicon Metal from the People's Republic of China: Preliminary Results and Preliminary Rescission...

    Science.gov (United States)

    2010-07-15

    ... International Trade Administration Silicon Metal from the People's Republic of China: Preliminary Results and... antidumping duty order on silicon metal from the People's Republic of China (``PRC''). The period of review... order on silicon metal from the PRC of three companies: Datong Jinneng Industrial Silicon Co., Ltd...

  4. Quality assurance in MR image guided adaptive brachytherapy for cervical cancer: Final results of the EMBRACE study dummy run.

    Science.gov (United States)

    Kirisits, Christian; Federico, Mario; Nkiwane, Karen; Fidarova, Elena; Jürgenliemk-Schulz, Ina; de Leeuw, Astrid; Lindegaard, Jacob; Pötter, Richard; Tanderup, Kari

    2015-12-01

    Upfront quality assurance (QA) is considered essential when starting a multicenter clinical trial in radiotherapy. Despite the long experience gained for external beam radiotherapy (EBRT) trials, there are only limited audit QA methods for brachytherapy (BT) and none include the specific aspects of image guided adaptive brachytherapy (IGABT). EMBRACE is a prospective multicenter trial aiming to assess the impact of (MRI)-based IGABT in locally advanced cervical cancer. An EMBRACE dummy run was designed to identify sources and magnitude of uncertainties and errors considered important for the evaluation of clinical, and dosimetric parameters and their relation to outcome. Contouring, treatment planning and dose reporting was evaluated and scored with a categorical scale of 1-10. Active feedback to centers was provided to improve protocol compliance and reporting. A second dummy run was required in case of major deviations (score 30 cases) had better performance as compared to centers with limited experience. The comprehensive dummy run designed for the EMBRACE trial has been a feasible tool for QA in IGABT of cervix cancer. It should be considered for future IGABT trials and could serve as the basis for continuous quality checks for brachytherapy centers. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  5. Clinical implementation of a new electronic brachytherapy system for skin brachytherapy

    OpenAIRE

    Pons-Llanas, Olga; Ballester-S?nchez, Rosa; Celada-?lvarez, Francisco Javier; Candela-Juan, Cristian; Garc?a-Mart?nez, Teresa; Llavador-Ros, Margarita; Botella-Estrada, Rafael; Barker, Christopher A.; Ballesta, Antonio; Tormo-Mic?, Alejandro; Rodr?guez, Silvia; Perez-Calatayud, Jose

    2014-01-01

    Although surgery is usually the first-line treatment for nonmelanoma skin cancers, radiotherapy (RT) may be indicated in selected cases. Radiation therapy as primary therapy can result in excellent control rates, cosmetics, and quality of life. Brachytherapy is a radiation treatment modality that offers the most conformal option to patients. A new modality for skin brachytherapy is electronic brachytherapy. This involves the placement of a high dose rate X-ray source directly in a skin applic...

  6. Intravascular brachytherapy for peripheral vascular disease

    Directory of Open Access Journals (Sweden)

    Hagen, Anja

    2008-09-01

    Full Text Available Scientific background: Percutaneous transluminal angioplasties (PTA through balloon dilatation with or without stenting, i.e. vessel expansion through balloons with or without of implantation of small tubes, called stents, are used in the treatment of peripheral artery occlusive disease (PAOD. The intravascular vessel irradiation, called intravascular brachytherapy, promises a reduction in the rate of repeated stenosis (rate of restenosis after PTA. Research questions: The evaluation addresses questions on medical efficacy, cost-effectiveness as well as ethic, social and legal implications in the use of brachytherapy in PAOD patients. Methods: A systematic literature search was conducted in August 2007 in the most important medical electronic databases for publications beginning from 2002. The medical evaluation included randomized controlled trials (RCT. The information synthesis was performed using meta-analysis. Health economic modeling was performed with clinical assumptions derived from the meta-analysis and economical assumptions derived from the German Diagnosis Related Groups (G-DRG-2007. Results: Medical evaluation: Twelve publications about seven RCT on brachytherapy vs. no brachytherapy were included in the medical evaluation. Two RCT showed a significant reduction in the rate of restenosis at six and/or twelve months for brachytherapy vs. no brachytherapy after successful balloon dilatation, the relative risk in the meta-analysis was 0.62 (95% CI: 0.46 to 0.84. At five years, time to recurrence of restenosis was significantly delayed after brachytherapy. One RCT showed a significant reduction in the rate of restenosis at six months for brachytherapy vs. no brachytherapy after PTA with optional stenting, the relative risk in the meta-analysis was 0.76 (95% CI: 0.61 to 0.95. One RCT observed a significantly higher rate of late thrombotic occlusions after brachytherapy in the subgroup of stented patients. A single RCT for brachytherapy

  7. Hellenic Amateur Astronomy Association's activities: Preliminary results on Perseids 2010

    Science.gov (United States)

    Maravelias, G.

    2011-01-01

    Preliminary results on the Perseids 2010 are presented. Visual and video observations were obtained by the author and a first reduction of the visual data shows that a maximum of ZHR ~120 was reached during the night 12-13 of August 2010. Moreover, a video setup was tested (DMK camera and UFO Capture v2) and the results show that, under some limitations, valuable data can be obtained.

  8. Nasopharyngeal Carcinoma Treated with Precision-Oriented Radiation Therapy Techniques Including Intensity-Modulated Radiotherapy: Preliminary Results

    Directory of Open Access Journals (Sweden)

    Wen-Shan Liu

    2004-02-01

    Full Text Available This paper reports preliminary results with intensity-modulated radiotherapy (IMRT in nasopharyngeal carcinoma (NPC. Between August 2000 and May 2001, we treated 19 patients with NPC using IMRT. Twelve patients had stage I-II disease and seven had stage III-IV disease. Six patients received 9.0-19.8 Gy three-dimensional conformal radiotherapy (3D-CRT before IMRT and 18 patients received a brachytherapy boost after IMRT. The mean follow-up time was 13.0 months. All patients with stage II-IV disease except one received two cycles of chemoradiotherapy with cisplatin and 5-fluorouracil (5-FU during radiotherapy, followed by two to four cycles of chemotherapy after radiotherapy. Tumor response was assessed using clinical examination and computerized tomography or magnetic resonance imaging. The mean doses administered to the gross tumor volume and clinical tumor volume were 70.9 Gy and 63.2 Gy, respectively. The mean doses administered to the right and left parotid glands were 38.1 Gy and 38.6 Gy, respectively. All 19 patients had a complete response of primary and lymph node disease. Grade III mucositis developed during chemoradiotherapy in 15 patients (79%. In addition, clinical grade I xerostomia was recorded in nine patients, grade II in nine, and grade III in one. This study demonstrated that 3D-CRT, IMRT, intracavitary brachytherapy, and chemotherapy are effective and safe methods to treat NPC. Although IMRT treatment spared parotid gland function, its efficacy may be significantly influenced by disease stage and location of the neck lymph nodes. More cases and a longer follow-up to assess survival and complications are planned.

  9. Brachytherapy in breast cancer: an effective alternative

    Science.gov (United States)

    Chicheł, Adam

    2014-01-01

    Breast conserving surgery (BCS) with following external beam radiation therapy (EBRT) of the conserved breast has become widely accepted in the last decades for the treatment of early invasive breast cancer. The standard technique of EBRT after BCS is to treat the whole breast up to a total dose of 42.5 to 50 Gy. An additional dose is given to treated volume as a boost to a portion of the breast. In the early stage of breast cancer, research has shown that the area requiring radiation treatment to prevent the cancer from local recurrence is the breast tissue that surrounds the area where the initial cancer was removed. Accelerated partial breast irradiation (APBI) is an approach that treats only the lumpectomy bed plus a 1-2 cm margin rather than the whole breast and as a result allows accelerated delivery of the radiation dose in four to five days. There has been a growing interest for APBI and various approaches have been developed under phase I-III clinical studies; these include multicatheter interstitial brachytherapy, balloon catheter brachytherapy, conformal external beam radiation therapy (3D-EBRT) and intra-operative radiation therapy (IORT). Balloon-based brachytherapy approaches include MammoSite, Axxent electronic brachytherapy, Contura, hybrid brachytherapy devices. Another indication for breast brachytherapy is reirradiation of local recurrence after mastectomy. Published results of brachytherapy are very promising. We discuss the current status, indications, and technical aspects of breast cancer brachytherapy. PMID:26327829

  10. Particle Simulation of Plasma Blob Dynamics: Preliminary Results

    OpenAIRE

    Hiroki, HASEGAWA; Seiji, ISHIGURO

    2012-01-01

    A three dimensional electrostatic plasma particle code has been developed to investigate blob dynamics. Some results of preliminary simulations are in agreement with previous studies based on a two-dimensional reduced fluid model. When periodic boundary condition is applied in the ambient magnetic field direction, it was observed that a blob evolves to a mushroom-shaped structure. Furthermore, the relation between the observed blob propagation speed and the initial blob size is consistent wit...

  11. Preliminary Results of the Louisiana Sex Offender Treatment Program

    Directory of Open Access Journals (Sweden)

    Lee A. Underwood

    2015-12-01

    Full Text Available The purpose of this study was to offer preliminary support for the Louisiana Sex Offender Treatment Program (LSOTP in addressing the needs of juvenile sex offenders. Research objectives were (1 to offer statistical evidence for reductions in anxiety, depression, cognitive distortion and negative attitudes towards women comparing a group of 21 adolescents, 12 of whom received services as usual and nine of whom participated in the LSOTP. A controlled experimental evaluation design was utilized. The juvenile sex offenders were randomly assigned to the experimental group for 12 weeks receiving treatment services and a control group receiving care “as usual” in a residential group care program. Participants in the experimental group experienced statistically significant decreases in cognitive distortions related specifically to rape and molestation.The results of this study offer preliminary support of the LSOTP as a best practices alternative to other treatment modalities.

  12. Stellar streams in the Galactic thick disk: preliminary results

    Science.gov (United States)

    Ramya, P.; Reddy, Bacham E.

    Here we report preliminary results of our study of chemical tagging of member stars of two Galactic stellar streams. Both the streams, kinematically belong to the thick disk component of the Galaxy. We analysed high resolution spectra of 42 member stars: 17 from Arcturus stream and 25 from ``AF06 stream''. The LTE (Local Thermodynamic Equilibrium) abundance analysis was performed differentially with respect to the sun. Abundance results suggest that both the streams are metal poor and enhanced in α-process elements (O, Mg, Si, Ca, Ti) very similar to the thick disk chemistry. Also, results suggest that the two streams probably did not originate by the dispersion of open clusters.

  13. Magnetic resonance image guided brachytherapy.

    Science.gov (United States)

    Tanderup, Kari; Viswanathan, Akila N; Kirisits, Christian; Frank, Steven J

    2014-07-01

    The application of magnetic resonance image (MRI)-guided brachytherapy has demonstrated significant growth during the past 2 decades. Clinical improvements in cervix cancer outcomes have been linked to the application of repeated MRI for identification of residual tumor volumes during radiotherapy. This has changed clinical practice in the direction of individualized dose administration, and resulted in mounting evidence of improved clinical outcome regarding local control, overall survival as well as morbidity. MRI-guided prostate high-dose-rate and low-dose-rate brachytherapies have improved the accuracy of target and organs-at-risk delineation, and the potential exists for improved dose prescription and reporting for the prostate gland and organs at risk. Furthermore, MRI-guided prostate brachytherapy has significant potential to identify prostate subvolumes and dominant lesions to allow for dose administration reflecting the differential risk of recurrence. MRI-guided brachytherapy involves advanced imaging, target concepts, and dose planning. The key issue for safe dissemination and implementation of high-quality MRI-guided brachytherapy is establishment of qualified multidisciplinary teams and strategies for training and education. Copyright © 2014 Elsevier Inc. All rights reserved.

  14. Preliminary results on heavy flavor physics at SLD

    Energy Technology Data Exchange (ETDEWEB)

    Usher, T. [Stanford Univ., CA (United States)

    1994-12-01

    The author reports on preliminary heavy flavor physics results from the SLD detector at the SLAC Linear Collider. Efficient tagging of b{bar b} events is achieved with an impact parameter technique that takes advantage of the small and stable interaction point of the SLC and all charged tracks in Z{sup 0} decays. This technique is applied to samples of Z{sup 0} events collected during the 1992 and 1993 physics runs. Preliminary measurements of the ratio R{sub b} = {Gamma}(Z{sup 0} {yields} b{bar b})/{Gamma}(Z{sup 0} {yields} hadrons) and the average B hadron lifetime <{tau}{sub B}> are reported. In a sample of 27K Z{sup 0} events, values of R{sub b} = 0.235 {+-} 0.006(stat.) {+-} 0.018(syst.) and <{tau}{sub B}> = 1.53 {+-} 0.006(stat.) {+-} 0.018(syst.) are obtained. In addition, the first measurement of the left-right asymmetry A{sub b} is reported. Using a sample of 38K Z{sup 0} events with a luminosity weighted electron polarization of 62%, the author obtains a preliminary value of A{sub b} = 0.94 {+-} 0.006(stat.) {+-} 0.018(syst.).

  15. High dose rate brachytherapy for oral cancer

    Science.gov (United States)

    YamazakI, Hideya; Yoshida, Ken; Yoshioka, Yasuo; Shimizutani, Kimishige; Furukawa, Souhei; Koizumi, Masahiko; Ogawa, Kazuhiko

    2013-01-01

    Brachytherapy results in better dose distribution compared with other treatments because of steep dose reduction in the surrounding normal tissues. Excellent local control rates and acceptable side effects have been demonstrated with brachytherapy as a sole treatment modality, a postoperative method, and a method of reirradiation. Low-dose-rate (LDR) brachytherapy has been employed worldwide for its superior outcome. With the advent of technology, high-dose-rate (HDR) brachytherapy has enabled health care providers to avoid radiation exposure. This therapy has been used for treating many types of cancer such as gynecological cancer, breast cancer, and prostate cancer. However, LDR and pulsed-dose-rate interstitial brachytherapies have been mainstays for head and neck cancer. HDR brachytherapy has not become widely used in the radiotherapy community for treating head and neck cancer because of lack of experience and biological concerns. On the other hand, because HDR brachytherapy is less time-consuming, treatment can occasionally be administered on an outpatient basis. For the convenience and safety of patients and medical staff, HDR brachytherapy should be explored. To enhance the role of this therapy in treatment of head and neck lesions, we have reviewed its outcomes with oral cancer, including Phase I/II to Phase III studies, evaluating this technique in terms of safety and efficacy. In particular, our studies have shown that superficial tumors can be treated using a non-invasive mold technique on an outpatient basis without adverse reactions. The next generation of image-guided brachytherapy using HDR has been discussed. In conclusion, although concrete evidence is yet to be produced with a sophisticated study in a reproducible manner, HDR brachytherapy remains an important option for treatment of oral cancer. PMID:23179377

  16. Preliminary Results on Uncertainty Quantification for Pattern Analytics

    Energy Technology Data Exchange (ETDEWEB)

    Stracuzzi, David John [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Brost, Randolph [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Chen, Maximillian Gene [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Malinas, Rebecca [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Peterson, Matthew Gregor [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Phillips, Cynthia A. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Robinson, David G. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Woodbridge, Diane [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

    2015-09-01

    This report summarizes preliminary research into uncertainty quantification for pattern ana- lytics within the context of the Pattern Analytics to Support High-Performance Exploitation and Reasoning (PANTHER) project. The primary focus of PANTHER was to make large quantities of remote sensing data searchable by analysts. The work described in this re- port adds nuance to both the initial data preparation steps and the search process. Search queries are transformed from does the specified pattern exist in the data? to how certain is the system that the returned results match the query? We show example results for both data processing and search, and discuss a number of possible improvements for each.

  17. Escherichia coli O26 IN RAW BUFFALO MILK: PRELIMINARY RESULTS

    Directory of Open Access Journals (Sweden)

    A. Rella

    2013-02-01

    Full Text Available Escherichia coli O26 is considered to be one of the most important food-borne pathogen. In this study, 120 buffalo milk samples collected in Lazio and in Apulia regions were tested for the presence of E. coli O26. One buffalo milk sample (0,8% tested positive for E. coli O26; the isolate was positive at the verocytotoxicity test and it showed resistance properties to different antimicrobial classes. These preliminary results highlight the need to monitor the foods of animal origin used for production and eaten by a wide range of persons, respect VTEC organism.

  18. Preliminary results of SMM exposed aluminized Kapton and silvered Teflon

    Science.gov (United States)

    Santos-Mason, B.

    1985-01-01

    Early Space Shuttle flights revealed that organic materials, such as those used in thermal control blankets and paints in the payload bay, were adversely affected in the low Earth orbit environment. Examination of eroded surfaces on these early flights and materials experiments performed on subsequent flights led to the conclusion that atomic oxygen present at Shuttle operating altitudes was responsible for surface degradation. The Solar Maximum Mission provided surfaces that had been exposed in real time to atomic oxygen and ultraviolet radiation. Preliminary results of studies of the microscopic surface effects on silvered Teflon and aluminized Kapton used for thermal control on the Solar Maximum Mission are presented.

  19. Preliminary results of a galactic background survey at 45 MHz

    Energy Technology Data Exchange (ETDEWEB)

    Bitran, M.; May, J.; Aparici, J.

    1981-12-01

    Preliminary results of a survey of the galactic background at 45 MHz recently carried out at the MaipuRadio Astronomy Observatory are shown. The radiotelescope is a transit instrument that consists of a rectangular filled array of 528 dipoles with an angular resolution of 2.1 deg in declination and 4.6 deg in righ ascension. These first observations cover the region of the sky between declinations from -30 deg to -37 deg and they have been obtained with a multiple beam system.

  20. King County Metro Battery Electric Bus Demonstration: Preliminary Project Results

    Energy Technology Data Exchange (ETDEWEB)

    2017-05-22

    The U.S. Federal Transit Administration (FTA) funds a variety of research projects that support the commercialization of zero-emission bus technology. To evaluate projects funded through these programs, FTA has enlisted the help of the National Renewable Energy Laboratory (NREL) to conduct third-party evaluations of the technologies deployed under the FTA programs. NREL works with the selected agencies to evaluate the performance of the zero-emission buses compared to baseline conventional buses in similar service. The evaluation effort will advance the knowledge base of zero-emission technologies in transit bus applications and provide 'lessons learned' to aid other fleets in incrementally introducing next generation zero-emission buses into their operations. This report provides preliminary performance evaluation results from a demonstration of three zero-emission battery electric buses at King County Metro in King County, Washington. NREL developed this preliminary results report to quickly disseminate evaluation results to stakeholders. Detailed evaluation results will be published in future reports.

  1. Factors Associated With Optimal Long-Term Cosmetic Results in Patients Treated With Accelerated Partial Breast Irradiation Using Balloon-Based Brachytherapy

    Energy Technology Data Exchange (ETDEWEB)

    Vicini, Frank A., E-mail: fvicini@beaumont.edu [Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI (United States); Keisch, Martin [Miami Brachytherapy Center, Cancer Healthcare Associates, Miami, FL (United States); Shah, Chirag [Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI (United States); Goyal, Sharad; Khan, Atif J. [Department of Radiation Oncology, Cancer Institute of New Jersey, New Brunswick, NJ (United States); Beitsch, Peter D. [Dallas Breast Center, Dallas, TX (United States); Lyden, Maureen [BioStat International Inc, Tampa, FL (United States); Haffty, Bruce G. [Department of Radiation Oncology, Cancer Institute of New Jersey, New Brunswick, NJ (United States)

    2012-06-01

    Purpose: To evaluate factors associated with optimal cosmetic results at 72 months for early-stage breast cancer patients treated with Mammosite balloon-based accelerated partial breast irradiation (APBI). Methods and Materials: A total of 1,440 patients (1,449 cases) with early-stage breast cancer undergoing breast-conserving therapy were treated with balloon-based brachytherapy to deliver APBI (34 Gy in 3.4-Gy fractions). Cosmetic outcome was evaluated at each follow-up visit and dichotomized as excellent/good (E/G) or fair/poor (F/P). Follow-up was evaluated at 36 and 72 months to establish long-term cosmesis, stability of cosmesis, and factors associated with optimal results. Results: The percentage of evaluable patients with excellent/good (E/G) cosmetic results at 36 months and more than 72 months were 93.3% (n = 708/759) and 90.4% (n = 235/260). Factors associated with optimal cosmetic results at 72 months included: larger skin spacing (p = 0.04) and T1 tumors (p = 0.02). Using multiple regression analysis, the only factors predictive of worse cosmetic outcome at 72 months were smaller skin spacing (odds ratio [OR], 0.89; confidence interval [CI], 0.80-0.99) and tumors greater than 2 cm (OR, 4.96, CI, 1.53-16.07). In all, 227 patients had both a 36-month and a 72-month cosmetic evaluation. The number of patients with E/G cosmetic results decreased only slightly from 93.4% at 3 years to 90.8% (p = 0.13) at 6 years, respectively. Conclusions: APBI delivered with balloon-based brachytherapy produced E/G cosmetic results in 90.4% of cases at 6 years. Larger tumors (T2) and smaller skin spacing were found to be the two most important independent predictors of cosmesis.

  2. Preliminary Results from the Smoke Aerosol Measurement Experiment - Reflight

    Science.gov (United States)

    Urban, D. L.; Ruff, G. A.; Mulholland, G. W.; Yuan, Z.; Cleary, T.; Yang, J.; Meyer, M. E.; Bryg, V. M.

    2012-01-01

    Preliminary results are presented from the Reflight of the Smoke Aerosol Measurement Experiment (SAME- R) which was conducted during Expedition 24 (July- September 2010). The reflight experiment built upon the results of the original flight during Expedition 15 by adding diagnostic measurements and expanding the test matrix. Five different materials representative of those found in spacecraft (Teflon, Kapton, cotton, silicone rubber and Pyrell) were heated to temperatures below the ignition point with conditions controlled to provide repeatable sample surface temperatures and air flow. Particle size determinations were made using aerosol instruments and by capturing particles for ground based examination in a Transmission Electron Microscope (TEM). Overall the majority of the average smoke particle sizes were found to be in the 200 to 400 nanometer range with the some of the quiescent cases producing substantially larger particles. When combined with particle morphology data from the TEM analysis, these results can be used to guide the design of future smoke detectors.

  3. Preliminary Results from the Cassini RADAR Ring Observations

    Science.gov (United States)

    West, Richard D.; Janssen, Michael A.; Zhang, Zhimeng; Cuzzi, Jeffrey N.; Anderson, Yanhua; Hamilton, Gary; Elachi, Charles; Cassini RADAR Science Team

    2017-10-01

    In its last year of operation, the Cassini spacecraft executed a series of short highly inclined orbits that brought it close to Saturn’s rings. The Cassini RADAR instrument collected active and passive data of the rings in five separate observations. These observations provided a unique opportunity to obtain backscatter measurements and relatively high-resolution brightness temperature measurements from the rings. Such measurements were never before possible from the spacecraft or the Earth due to high range. Preliminary examination of the active data shows major ring structural features such as the Cassini Division, the Encke Gap, and the Keeler Gap. This presentation will show preliminary processing results from the radar rings scans and discuss the calibration and processing issues. These ring scan measurements provide a 1-D profile of backscatter obtained at 2.2 cm wavelength that complements similar passive profiles obtained at optical, infrared, and microwave wavelengths. Such measurements can further constrain and inform models of the ring particle composition and structure, and the local vertical structure of the rings. This work is supported by the NASA Cassini Program at JPL - CalTech.

  4. Clinical implementation of a new electronic brachytherapy system for skin brachytherapy.

    Science.gov (United States)

    Pons-Llanas, Olga; Ballester-Sánchez, Rosa; Celada-Álvarez, Francisco Javier; Candela-Juan, Cristian; García-Martínez, Teresa; Llavador-Ros, Margarita; Botella-Estrada, Rafael; Barker, Christopher A; Ballesta, Antonio; Tormo-Micó, Alejandro; Rodríguez, Silvia; Perez-Calatayud, Jose

    2015-01-01

    Although surgery is usually the first-line treatment for nonmelanoma skin cancers, radiotherapy (RT) may be indicated in selected cases. Radiation therapy as primary therapy can result in excellent control rates, cosmetics, and quality of life. Brachytherapy is a radiation treatment modality that offers the most conformal option to patients. A new modality for skin brachytherapy is electronic brachytherapy. This involves the placement of a high dose rate X-ray source directly in a skin applicator close to the skin surface, and therefore combines the benefits of brachytherapy with those of low energy X-ray radiotherapy. The Esteya electronic brachytherapy system is specifically designed for skin surface brachytherapy procedures. The purpose of this manuscript is to describe the clinical implementation of the new Esteya electronic brachytherapy system, which may provide guidance for users of this system. The information covered includes patient selection, treatment planning (depth evaluation and margin determination), patient marking, and setup. The justification for the hypofractionated regimen is described and compared with others protocols in the literature. Quality assurance (QA) aspects including daily testing are also included. We emphasize that these are guidelines, and clinical judgment and experience must always prevail in the care of patients, as with any medical treatment. We conclude that clinical implementation of the Esteya brachytherapy system is simple for patients and providers, and should allow for precise and safe treatment of nonmelanoma skin cancers.

  5. DECOMPOSITION OF TARS IN MICROWAVE PLASMA – PRELIMINARY RESULTS

    Directory of Open Access Journals (Sweden)

    Mateusz Wnukowski

    2014-07-01

    Full Text Available The paper refers to the main problem connected with biomass gasification - a presence of tar in a product gas. This paper presents preliminary results of tar decomposition in a microwave plasma reactor. It gives a basic insight into the construction and work of the plasma reactor. During the experiment, researches were carried out on toluene as a tar surrogate. As a carrier gas for toluene and as a plasma agent, nitrogen was used. Flow rates of the gases and the microwave generator’s power were constant during the whole experiment. Results of the experiment showed that the decomposition process of toluene was effective because the decomposition efficiency attained above 95%. The main products of tar decomposition were light hydrocarbons and soot. The article also gives plans for further research in a matter of tar removal from the product gas.

  6. TSUNAMI PROPAGATION ALONG TAGUS ESTUARY (LISBON, PORTUGAL PRELIMINARY RESULTS

    Directory of Open Access Journals (Sweden)

    M. A. Viana-Baptista

    2006-01-01

    Full Text Available In this study we present preliminary results of flood calculation along Tagus Estuary, a catastrophic event that happened several times in the past, as described in historical documents, and that constitutes one of the major risk sources for Lisbon coastal area. To model inundation we used Mader’s SWAN model for the open ocean propagation with a 2 km grid, and Imamura’s TSUN2 with a 50 m grid covering the entire estuary. The seismic source was computed with the homogeneous elastic half space approach. Modelling results agree with historical reports. Synthetic flood areas correspond to the sites where there are morphological and sedimentary evidences of two known major events that stroke Lisbon: 1531-01-26 and 1755-11-01 tsunamis.

  7. Unit cell sparger test program and preliminary test results

    Energy Technology Data Exchange (ETDEWEB)

    Park, C. K.; Cho, S.; Song, C. H.; Yun, Y. Z.; Jeong, H. Z.; Chon, C. Y. [KAERI, Taejon (Korea, Republic of)

    2001-10-01

    KAERI performs blowdown tests to asess the performance of the prototype sparger which will be used in a APR1400 reactor. This report presents overview of the unit cell sparger test program and results of a preliminary analysis of the data from CPT-3 Test. CPT-3 Test was the third blowdown experiment conducted to determine the influence of air mass in the piping on the IRWST (In-containment Refueling Water Storage Tank) boundary during an operation of Safety Depressurization and Vent System (SDVS). The test was conducted from an initial system pressure of 14.6 MPa, a steam temperature of 343 .deg. C, and an air mass of 3.31 lb. The maximum pressure was observed at the bottom of the IRWST, and the frequency of the pressure wave was less than 6.4 Hz.

  8. [Motor evoked potentials of the perineal floor. Preliminary results].

    Science.gov (United States)

    Opsomer, R J; Van Cangh, P J; Humblet, Y; Abi Aad, A; Rossini, P M

    1989-01-01

    Neuromotor pathways from the brain to the pelvic floor have been poorly documented. The recent development of Motor Evoked Potentials may well fill this gap in our basic knowledge. Our technique consists of transcutaneous stimulation of the motor cortex and sacral roots with a magnetic device while recording the evoked response from the bulbocavernosus muscle and anal sphincter. Cortical stimulation is performed first at rest and then during voluntary contraction of the examined muscles ("facilitation" procedure). Sacral root stimulation is performed at rest. Stimulation at 2 different levels allows measurement of the total transit time (brain to muscle transit time) and the peripheral transit time (sacral roots to muscle). By subtracting the latter from the former, the central transit time (brain to sacral roots) is obtained. The technique is painless, and to our knowledge no side effects have been reported. The authors present the preliminary results of this new technique.

  9. Preliminary Results of the CASCADE Hidden Sector Photon Search

    CERN Document Server

    Woollett, Nathan; Burt, Graeme; Chattopadhyay, Swapan; Dainton, John; Dexter, Amos; Goudket, Phillipe; Jenkins, Michael; Kalliokoski, Matti; Moss, Andrew; Pattalwar, Shrikant; Thakker, Trina; Williams, Peter

    2015-01-01

    Light shining through a wall experiments can be used to make measurements of photon-WISP couplings. The first stage of the CASCADE experiment at the Cockcroft Institute of Accelerator Science and Technology is intended to be a proof-of-principle experiment utilising standard microwave technologies to make a modular, cryogenic HSP detector to take advantage of future high-power superconducting cavity tests. In these proceedings we will be presenting the preliminary results of the CASCADE LSW experiment showing a peak expected exclusion of $1.10 \\times 10^{-8}$ in the mass range from 1.96$\\mu$eV to 5.38$\\mu$eV, exceeding current limits.

  10. Preliminary Results from the Mars Pathfinder ASI/MET Experiment

    Science.gov (United States)

    Haberle, R. M.; Schofield, J. T.; Crisp, D.; Barnes, J. R.; Magalhaes, J. A.; Murphy, J. R.; Seiff, A.; Wilson, G.; Larsen, S.; Young, Richard E. (Technical Monitor)

    1997-01-01

    Mars Pathfinder successfully landed in the Ares Vallis flood plain (19.3 N, 33.6 W) on July 4, 1997. The spacecraft carried a suite of instruments to record the structure of the atmosphere during the entry, descent, and landing as well as for monitoring meteorological phenomenon while on the surface. Collectively, these instruments are known as the ASI/MET experiment (Atmospheric Structure Investigation/Meteorology). In this paper we present preliminary results from the ASI/MET experiment. As of this writing, the spacecraft is healthy and continues to take daily meteorological measurements. We expect this will continue for almost one more earth year. Additional information is contained in the original extended abstract.

  11. Preliminary medical results of the Mir year-long mission

    Science.gov (United States)

    Grigoriev, A. I.; Bugrov, S. A.; Bogomolov, V. V.; Egorov, A. D.; Kozlovskaya, I. B.; Pestov, I. D.; Polyakov, V. V.; Tarasov, I. K.

    The basic goal of medical investigations during and after the 366-day mission was to accumulate data about physiological responses to such a long exposure to microgravity. In flight, cardiovascular and other systems were examined in detail and the efficacy of countermeasures used was assessed. After flight, physiological systems were also followed very carefully. According to the preliminary data, the medical results obtained during and after flight give evidence that man can well adapt to a year-long space flight, maintaining good health and adequate work capacity. The readaptation process was very similar to that observed after shorter flights (6-II months). As compared to former flights, no new or qualitatively different changes in the vital systems of the body were seen. The observations indicate that the duration of manned space missions can be further increased.

  12. The EU-ADR project: preliminary results and perspective.

    Science.gov (United States)

    Trifiro, Gianluca; Fourrier-Reglat, Annie; Sturkenboom, Miriam C J M; Díaz Acedo, Carlos; Van Der Lei, Johan

    2009-01-01

    The EU-ADR project aims to exploit different European electronic healthcare records (EHR) databases for drug safety signal detection. In this paper we describe the project framework and the preliminary results. As first step we created a ranked list of the events that are deemed to be important in pharmacovigilance as mining on all possible events was considered to unduly increase the number of spurious signals. All the drugs that are potentially associated to these events will be detected via data mining techniques. Data sources are eight 8 databases in four countries (Denmark, Italy, the Netherlands, and the United Kingdom) that are virtually linked through harmonisation of input data followed by local elaboration of input data through custom-built software (Jerboa). All the identified drug-event associations (signals) will be thereafter biologically substantiated and epidemiologically validated. To date, only Upper gastrointestinal bleeding (UGIB) event has been used to test the ability of the system in signal detection. An initial ranked list comprising 23 adverse events was identified. The top-ranking events were: cutaneous bullous eruptions, acute renal failure, acute myocardial infarction, anaphylactic shock, and rhabdomyolysis. Regarding the UGIB test, a total of 48,016 first-ever episodes were identified. The age-standardized incidence rates of UGIB varied between 40-100/100,000 person-years depending on country and type of healthcare database. A statistically significant association between use of NSAIDs and UGIB was detected in all of the databases. a dynamic ranked list of 23 adverse drug events judged as important in pharmacovigilance was created to permit focused data mining. Preliminary results on the UGIB event detection demonstrate the feasibility of harmonizing various health care databases in different European countries through a distributed network approach.

  13. The American Brachytherapy Society Treatment Recommendations for Locally Advanced Carcinoma of the Cervix Part II: High Dose-Rate Brachytherapy

    Science.gov (United States)

    Viswanathan, Akila N.; Beriwal, Sushil; De Los Santos, Jennifer; Demanes, D. Jeffrey; Gaffney, David; Hansen, Jorgen; Jones, Ellen; Kirisits, Christian; Thomadsen, Bruce; Erickson, Beth

    2012-01-01

    Purpose This report presents the 2011 update to the American Brachytherapy Society (ABS) high-dose-rate (HDR) brachytherapy guidelines for locally advanced cervical cancer. Methods Members of the American Brachytherapy Society (ABS) with expertise in cervical cancer brachytherapy formulated updated guidelines for HDR brachytherapy using tandem and ring, ovoids, cylinder or interstitial applicators for locally advanced cervical cancer were revised based on medical evidence in the literature and input of clinical experts in gynecologic brachytherapy. Results The Cervical Cancer Committee for Guideline Development affirms the essential curative role of tandem-based brachytherapy in the management of locally advanced cervical cancer. Proper applicator selection, insertion, and imaging are fundamental aspects of the procedure. Three-dimensional imaging with magnetic resonance or computed tomography or radiographic imaging may be used for treatment planning. Dosimetry must be performed after each insertion prior to treatment delivery. Applicator placement, dose specification and dose fractionation must be documented, quality assurance measures must be performed, and follow-up information must be obtained. A variety of dose/fractionation schedules and methods for integrating brachytherapy with external-beam radiation exist. The recommended tumor dose in 2 Gray (Gy) per fraction radiobiologic equivalence (EQD2) is 80–90 Gy, depending on tumor size at the time of brachytherapy. Dose limits for normal tissues are discussed. Conclusion These guidelines update those of 2000 and provide a comprehensive description of HDR cervical cancer brachytherapy in 2011. PMID:22265437

  14. Advancements in brachytherapy

    DEFF Research Database (Denmark)

    Tanderup, Kari; Ménard, Cynthia; Polgar, Csaba

    2017-01-01

    Brachytherapy is a radiotherapy modality associated with a highly focal dose distribution. Brachytherapy treats the cancer tissue from the inside, and the radiation does not travel through healthy tissue to reach the target as with external beam radiotherapy techniques. The nature of brachytherap...... in terms of controlling dose and demonstrating excellent clinical outcome. Interests in focal, hypofractionated and adaptive treatments are increasing, and brachytherapy has significant potential to develop further in these directions with current and new treatment indications....

  15. Five-year results: the initial clinical trial of MammoSite balloon brachytherapy for partial breast irradiation in early-stage breast cancer.

    Science.gov (United States)

    Benitez, Pamela R; Keisch, Martin E; Vicini, Frank; Stolier, Alan; Scroggins, Troy; Walker, Alonzo; White, Julia; Hedberg, Peter; Hebert, Mary; Arthur, Doug; Zannis, Vic; Quiet, Coral; Streeter, Oscar; Silverstein, Mel

    2007-10-01

    Patients with early-stage invasive ductal breast cancer were prospectively evaluated using MammoSite RTS balloon brachytherapy (RTS Cytyc Corp, Marlborough, MA) as the sole modality for delivering accelerated partial breast irradiation to the lumpectomy bed with breast-conserving surgery. This report presents the 5-year results of the treated patients. From May 2000 to October 2001, 70 patients were enrolled in this prospective study. Forty-three patients completed accelerated partial breast irradiation with MammoSite brachytherapy following lumpectomy and axillary staging. Thirty-six patients have been followed for a median of 5.5 years (mean 65.2 months). Criteria for entry into the study were unifocal invasive ductal carcinoma, tumor size or = 45 years, absence of extensive intraductal component, cavity size > or = 3 cm in 1 dimension, node-negative, and final margins negative per National Surgical Adjuvant Breast and Bowel Project definition. A minimum balloon-to-skin surface distance of 5 mm was required. A dose of 34 Gy was delivered in 10 fractions over 5 days prescribed to 1 cm from the applicator surface using iridium-192 high-dose-rate brachytherapy. Data on infection, seromas, cosmetic outcome, and toxicities were collected at 3 and 6 months and at yearly intervals. Local recurrences, both true recurrences in the lumpectomy bed and failures outside the initially treated target volume (elsewhere failures), were recorded. Contralateral breast failure rates were noted. The catheter was not implanted in 16 of the 70 enrolled patients due to cavity size not amenable to balloon placement (n = 10), ineligible by criteria (n = 4), and skin spacing (n = 2). Fifty-four patients were implanted and 43 were successfully treated with MammoSite balloon brachytherapy. Reasons for catheter explantation in 11 patients were poor cavity conformance in 7, inadequate skin spacing in 2, positive node in 1 and age less than 45 years in 1. Of the 43 patients who completed

  16. Prostate brachytherapy - discharge

    Science.gov (United States)

    Implant therapy - prostate cancer - discharge; Radioactive seed placement - discharge ... You had a procedure called brachytherapy to treat prostate cancer. Your treatment lasted 30 minutes or more, ...

  17. Uranium and thorium recovery in thorianite ore-preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Gaiotte, Joao V.M. [Universidade Federal de Alfenas, Pocos de Caldas, MG (Brazil); Villegas, Raul A.S.; Fukuma, Henrique T., E-mail: rvillegas@cnen.gov.br, E-mail: htfukuma@cnen.gov.br [Comissao Nacional de Energia Nuclear (CNEN), Pocos de Caldas, MG (Brazil). Lab. de Pocos de Caldas

    2011-07-01

    This work presents the preliminary results of the studies aiming to develop a hydrometallurgical process to produce uranium and thorium concentrates from thorianite ore from Amapa State, Brazil. This process comprises two major parts: acid leaching and Th/U recovery using solvent extraction strategies. Thorianite ore has a typical composition of 60 - 70% of thorium, 8 - 10% lead and 7 - 10% uranium. Sulfuric acid leaching operational conditions were defined as follows: acid/ore ratio 7.5 t/t, ore size below 65 mesh (Tyler), 2 hours leaching time and temperature of 100 deg C. Leaching tests results showed that uranium and thorium recovery exceeded 95%, whereas 97% of lead ore content remained in the solid form. Uranium and thorium simultaneous solvent extraction is necessary due to high sulfate concentration in the liquor obtained from leaching, so the Primene JM-T primary anime was used for this extraction step. Aqueous raffinate from extraction containing sulfuric acid was recycled to the leaching step, reducing acid uptake around 60%, to achieve a net sulfuric acid consumption of 3 t/t of ore. Uranium and thorium simultaneous stripping was performed using sodium carbonate solution. In the aqueous stripped it was added sulfuric acid at pH 1.5, followed by a second solvent extraction step using the tertiary amine Alamine 336. The following stripping step was done with a solution of sodium chloride, resulting in a final solution of 23 g L-1 uranium. (author)

  18. Tissue characterization using magnetic resonance elastography: preliminary results*

    Science.gov (United States)

    Kruse, S. A.; Smith, J. A.; Lawrence, A. J.; Dresner, M. A.; Manduca, A.; Greenleaf, J. F.; Ehman, R. L.; Kruse, S. A.; Smith, J. A.; Lawrence, A. J.; Dresner, M. A.; Manduca, A.; Greenleaf, J. F.

    2000-06-01

    The well-documented effectiveness of palpation as a diagnostic technique for detecting cancer and other diseases has provided motivation for developing imaging techniques for non-invasively evaluating the mechanical properties of tissue. A recently described approach for elasticity imaging, using propagating acoustic shear waves and phase-contrast MRI, has been called magnetic resonance elastography (MRE). The purpose of this work was to conduct preliminary studies to define methods for using MRE as a tool for addressing the paucity of quantitative tissue mechanical property data in the literature. Fresh animal liver and kidney tissue specimens were evaluated with MRE at multiple shear wave frequencies. The influence of specimen temperature and orientation on measurements of stiffness was studied in skeletal muscle. The results demonstrated that all of the materials tested (liver, kidney, muscle and tissue-simulating gel) exhibit systematic dependence of shear stiffness on shear rate. These data are consistent with a viscoelastic model of tissue mechanical properties, allowing calculation of two independent tissue properties from multiple-frequency MRE data: shear modulus and shear viscosity. The shear stiffness of tissue can be substantially affected by specimen temperature. The results also demonstrated evidence of shear anisotropy in skeletal muscle but not liver tissue. The measured shear stiffness in skeletal muscle was found to depend on both the direction of propagation and polarization of the shear waves.

  19. Development of a distress inventory for cancer: preliminary results.

    Directory of Open Access Journals (Sweden)

    Thomas B

    2002-01-01

    Full Text Available CONTEXT: Advances in cancer treatment have led to cure and prolongation of patients′ lives; however associated psychosocial problems, including distress, can detrimentally affect patients′ compliance with treatment and ultimately, their outcome. Symptom distress has been well addressed in many studies; however, psychological distress has only been quantified by using depression or anxiety scales/checklists or quality of life scales containing a distress sub scale/component or by the use of scales that are not psychological distress-specific. AIMS: The present study is an attempt to construct a psychological distress inventory for specific use with cancer patients. SETTINGS AND DESIGN: The standardisation sample consisted of 63 randomly selected patients with head and neck cancer who had undergone/ were undergoing curative treatment at the Regional Cancer Centre, Trivandrum. PATIENTS AND METHODS: The Distress Inventory for Cancer contained 57 positively and negatively toned items. An item analysis was conducted, followed by a factor analysis, thereby identifying the domains influencing distress. RESULTS: The final questionnaire contained 26 items subdivided into four domains viz. the personal, spiritual, physical, and the family domains, with each domain providing a sub score. The reliability coefficient (Cronbach′s alpha of the scale was found to be 0.85. CONCLUSIONS: These are the preliminary results of an ongoing study on global distress and tool development process. Reported here is the first step towards development of such tool.

  20. Preliminary results of diode laser surgery for early glottic cancer.

    Science.gov (United States)

    Tunçel, Umit; Cömert, Ela

    2013-09-01

    To analyze the complications and preliminary oncologic results of microscopic diode laser surgery. Prospective research. Ankara Oncology Education and Research Hospital. This prospective study was conducted on a series of 64 patients with glottic carcinoma (Tis, T1, T2) treated with microscopic endolaryngeal diode laser surgery. Four patients had local recurrence (6.2%). Local control and larynx preservation rates were 93.8% and 100%, respectively, for all groups of patients. Two-year disease-free survival after primary surgery was 100% for the Tis group, 96.4% for the T1 group, and 89.7% for the T2 group. When considering anterior commissure involvement, 2-year disease-free survival after primary surgery was 100% for the AC0 group, 85.7% for the AC1 group, and 85.7% for the AC2 group. Our study of microscopic diode laser resection of Tis, T1, and T2 glottic tumors showed similar oncologic results to previous reports about CO2 laser surgery. In anterior commissure tumors, both techniques had high complication and recurrence rates.

  1. Magnetic resonance imaging urodynamics: technique development and preliminary results

    Directory of Open Access Journals (Sweden)

    Gustavo Borghesi

    2006-06-01

    Full Text Available OBJECTIVES: In this preliminary study we report the development of the video urodynamic technique using magnetic resonance imaging (MRI. MATERIALS AND METHODS: We studied 6 women with genuine stress urinary incontinence, diagnosed by history and physical examination. Urodynamic examination was performed on multichannel equipment with the patient in the supine position. Coughing and Valsalva maneuvers were performed at volumes of 150, 250 and 350 mL. Simultaneously, MRI was carried out by using 1.5 T GE Signa CV/i high-speed scanner with real time fluoroscopic imaging possibilities. Fluoroscopic imaging was accomplished in the corresponding planes with T2-weighted single shot fast spin echo sequences at a speed of about 1 frame per second. Both studies were recorded and synchronized, resulting in a single video urodynamic examination. RESULTS: Dynamic MRI with cine-loop reconstruction of 1 image per second demonstrated the movement of all compartment of the relaxed pelvis during straining with the concomitant registration of abdominal and intravesical pressures. In 5 patients, urinary leakage was demonstrated during straining and the Valsalva leak point pressure (VLPP was determined as the vesical pressure at leak subtracted from baseline bladder pressure. Mean VLPP was 72.6 cm H2O (ranging from 43 to 122 cm H2O. CONCLUSIONS: The concept of MRI video urodynamics is feasible. In a clinical perspective, practical aspects represent a barrier to daily use and it should be recommended for research purposes.

  2. Preliminary results of quality assurance implementation in interventional cardiology

    Energy Technology Data Exchange (ETDEWEB)

    Nikodemova, D. [Slovak Medical Univ., Bratislava (Slovakia)

    2006-07-01

    Full text of publication follows: The dramatic increase in the frequency of the interventional procedures reflects the significant benefit which directly affects the patient. However parallel is this benefit accompanied by some concern about the consequent increase in doses to patient and staff. The question of safety has prompted the European commission and Who to issue and advise to conduct research in the area of the intervention radiology and to prepare standard protocols for quality assurance of interventional procedures. The presentation is focused on the optimization of interventional procedures in cardiology with aim to reduce the risk level of high exposures and to elaborate national standard methods of quality assurance program, as well as, the procedures used for the case of overexposure. Study was conducted at Slovak Institute of Cardiology, as well as, at Slovak Pediatric Cardiology Center, where wide variation of specific interventional procedures are performed. Skin dose date of patient were measured by Unfors Patient Skin Dosemeter P.S.D. - 4 and the values of Dose area products followed during all examinations. All technical parameters used for examinations were identified. Simultaneously were measured the personal doses of the medical staff present by the examinations. For personal dose measurements Unfors E.D.D.30 dose meter was used, as well as, T.L.D. for measurements of doses on extremities. Preliminary results confirm wide spread of patient doses and professional doses of medical staff. The causes of this spread will by discussed. (authors)

  3. The ice-layer in Antarctica : preliminary results from seismology

    Science.gov (United States)

    Leveque, J.; Wittlinger, G.; Maggi, A.

    2009-12-01

    Since the International Polar Year (IPY), there has been a marked increase in the number of broad-band seismic stations deployed on the thick continental ice-layer in Antarctica. We are involved in one of these deployments, CASE-IPY (Concordia Antarctica Seismic Experiment), which comprises seven stations to be installed in January 2010 on a profile between the scientific bases of Concordia (Dome C) and Vostok. The data recorded by these seismic stations are rare, will be exploited using many methods, including receiver function analysis. Receiver functions obtained using data recorded on thick ice (e.g. TAMSEIS deployment and the permanent stations QSPA (South Pole) and CCD (Concordia)) are anomalous when compared to those obtained from data recorded at rock stations. The first five seconds contain much of the anomalous signal: we see a positive arrival due to the rock-ice interface, preceded by a strong negative arrival. This pattern is seen on all the 28 stations we have analyzed, and is likely to be a global feature for stations installed on thick ice. We present preliminary results concerning this anomalous signal and its relationship to ice structure.

  4. Preliminary theoretical results on the solubility of ZnO

    Energy Technology Data Exchange (ETDEWEB)

    Sauer, Svea; Koeppen, Susan; Colombi Ciacchi, Lucio; Koehler, Christof; Frauenheim, Thomas [Bremen Center for Computational Materials Science, University of Bremen, Am Fallturm 1, 28359 Bremen (Germany)

    2011-07-01

    The toxicity of zinc oxide nanoparticles towards macrophage and epithelial cells is directly linked to their solubility in the surrounding solute. In this context a higher solubility was found for nanoparticles dissolved in cell culture media compared to nanoparticles in pure water. Therefore it is crucial to understand the interactions at the solid-water interface that lead to the particle dissolution. Our work puts a focus on the adsorption of different ions on the (10-10) zinc oxide surface in an aqueous environment. The employed ions range from simple anions to more complex molecules like dihydrogen phosphate. Ab-initio Molecular Dynamics simulations using a (4 x 2) slab model with a pre-adsorbed water layer are carried out in order to investigate the adsorption geometries. To simulate the dissolution of single Zn-atoms from the surface in the presence of different adsorbates a Metadynamics approach as implemented in CPMD is chosen. As the starting point we chose the dissolution of a single Zn-atom from the surface in the absence of adsorbed ions. Preliminary results are shown.

  5. This Month in Astronomical History: Preliminary Survey Results

    Science.gov (United States)

    Wilson, Teresa

    2017-01-01

    This Month in Astronomical History is a short (~500 word) column on the AAS website that revisits significant astronomical events or the lives of people who have made a large impact on the field. The monthly column began in July 2016 at the request of the Historical Astronomical Division. Examples of topics that have been covered include Comet Shoemaker-Levy’s collision with Jupiter, the discovery of the moons of Mars, the life of Edwin Hubble, Maria Mitchell’s comet discovery, and the launch of Sputnik II. A survey concerning the column is in progress to ensure the column addresses the interests and needs of a broad readership, including historians, educators, research astronomers, and the general public. Eleven questions focus on the style and content of the column, while eight collect simple demographics. The survey has been available on the AAS website since and was mentioned in several AAS newsletters; however, non-members of AAS were also recruited to include respondents from a variety of backgrounds. Preliminary results of the survey are presented and will be used to hone the style and content of the column to serve the widest possible audience. Responses continue to be collected at: https://goo.gl/forms/Lhwl2aWJl2Vkoo7v1

  6. SWCX Emission from the Helium Focusing Cone - Preliminary Results

    Science.gov (United States)

    Snowden, S. L.; Kuntz, K. D.; Collier, M. R.

    2008-01-01

    Preliminary results from an XMM-Newton campaign to study solar wind charge exchange (SWCX) emission from the heliospheric focusing cone of interstellar helium are presented. The detections of enhanced O VII and O VIII emission from the cone are at the 2(sigma) and 4(sigma) levels. The solar wind charge exchange (SWCX) emission in the heliosphere not associated with distinct objects (e.g., comets and planets including exospheric material in and near Earth s magnetosheath) is proportional to the flux of the solar wind and the space density of neutral material. The neutral material originates in the interstellar medium (ISM) and passes through the solar system due to the relative motion of the Sun and the ISM. The flow of the neutral material through the solar system is strongly perturbed by the Sun both by gravity and by radiation pressure. Because of the relative radiative scattering cross sections and the effect of solar gravitation the density of interstellar hydrogen near the Sun is reduced while interstellar helium is gravitationally focused. This creates a helium focusing cone downstream of the Sun [e.g., 1, and references therein].

  7. Ultrasonic Evaluation of Deeply Located Trabecular Bones - Preliminary Results

    Science.gov (United States)

    Cieślik, Lucyna; Litniewski, Jerzy

    The analysis of ultrasonic signals scattered by soft tissues have been successfully applied for their characterization. Similarly, the trabecular bone backscattered signal contains information about the properties of the bone structure. Therefore scattering-based ultrasonic technique potentially enables the assessment of microstructure characteristics of a bone. The femoral neck fracture often occurs in the course of osteoporosis and can lead to severe complications. Therefore assessment of femoral bone microstructure and condition is important and essential for the diagnosis and treatment monitoring. As far most of the trabecular bone investigations have been performed in vitro. The only in vivo measurements were carried out in transmission and mostly concerned estimation of the attenuation in heel bone. We have built the ultrasonic scanner that could be useful in acquiring the RF (Radio Frequency) echoes backscattered by the trabecular bone in vivo. Moreover, the bone scanner provides data not only from heel bone but from deeply located bones as well (e.g. femoral bone). It can be also used for easily accessible bones like heel bone or breastbone. In this case a gel-pad is applied to assure focusing of ultrasound in trabecular bone (approximately 10 mm beneath the cortical bone). This study presents preliminary results of the attenuating properties evaluation of trabecular bone from the ultrasonic echoes backscattered by heel bone and femoral neck.

  8. Preliminary results from a crowdsourcing experiment in immunohistochemistry.

    Science.gov (United States)

    Della Mea, Vincenzo; Maddalena, Eddy; Mizzaro, Stefano; Machin, Piernicola; Beltrami, Carlo A

    2014-01-01

    Crowdsourcing, i.e., the outsourcing of tasks typically performed by a few experts to a large crowd as an open call, has been shown to be reasonably effective in many cases, like Wikipedia, the Chess match of Kasparov against the world in 1999, and several others. The aim of the present paper is to describe the setup of an experimentation of crowdsourcing techniques applied to the quantification of immunohistochemistry. Fourteen Images from MIB1-stained breast specimens were first manually counted by a pathologist, then submitted to a crowdsourcing platform through a specifically developed application. 10 positivity evaluations for each image have been collected and summarized using their median. The positivity values have been then compared to the gold standard provided by the pathologist by means of Spearman correlation. Contributors were in total 28, and evaluated 4.64 images each on average. Spearman correlation between gold and crowdsourced positivity percentages is 0.946 (p crowdsourcing for an image analysis task that is currently time-consuming when done by human experts. Crowdsourced work can be used in various ways, in particular statistically agregating data to reduce identification errors. However, in this preliminary experimentation we just considered the most basic indicator, that is the median positivity percentage, which provided overall good results. This method might be more aimed to research than routine: when a large number of images are in need of ad-hoc evaluation, crowdsourcing may represent a quick answer to the need.

  9. Mapping urban forest tree species using IKONOS imagery: preliminary results.

    Science.gov (United States)

    Pu, Ruiliang

    2011-01-01

    A stepwise masking system with high-resolution IKONOS imagery was developed to identify and map urban forest tree species/groups in the City of Tampa, Florida, USA. The eight species/groups consist of sand live oak (Quercus geminata), laurel oak (Quercus laurifolia), live oak (Quercus virginiana), magnolia (Magnolia grandiflora), pine (species group), palm (species group), camphor (Cinnamomum camphora), and red maple (Acer rubrum). The system was implemented with soil-adjusted vegetation index (SAVI) threshold, textural information after running a low-pass filter, and brightness threshold of NIR band to separate tree canopies from non-vegetated areas from other vegetation types (e.g., grass/lawn) and to separate the tree canopies into sunlit and shadow areas. A maximum likelihood classifier was used to identify and map forest type and species. After IKONOS imagery was preprocessed, a total of nine spectral features were generated, including four spectral bands, three hue-intensity-saturation indices, one SAVI, and one texture image. The identified and mapped results were examined with independent ground survey data. The experimental results indicate that when classifying all the eight tree species/ groups with the high-resolution IKONOS image data, the identifying accuracy was very low and could not satisfy a practical application level, and when merging the eight species/groups into four major species/groups, the average accuracy is still low (average accuracy = 73%, overall accuracy = 86%, and κ = 0.76 with sunlit test samples). Such a low accuracy of identifying and mapping the urban tree species/groups is attributable to low spatial resolution IKONOS image data relative to tree crown size, to complex and variable background spectrum impact on crown spectra, and to shadow/shaded impact. The preliminary results imply that to improve the tree species identification accuracy and achieve a practical application level in urban area, multi-temporal (multi

  10. Stock Market Reaction to CEO Appointment – Preliminary Results

    Directory of Open Access Journals (Sweden)

    Katarzyna Byrka-Kita

    2017-06-01

    Full Text Available Purpose: The aim of this paper is to examine shareholders’ reaction to the decision of the supervisory board to appoint a CEO in companies listed on the Warsaw Stock Exchange. Methodology: An event study and the mean-adjusted model were applied. The abnormal returns were measured as the CAAR in the entire (-60, + 60 window and selected sub-windows. Findings: The obtained values of abnormal returns indicate the shareholder’s negative reaction. Throughout the observation window, they oscillate slightly below zero, and in the window (0, +20 they are negative at -1.566%. Irrespective of the observation window, negative abnormal returns were obtained for over half of the observation (52–57%. Therefore, preliminary results indicate the predominance of the information effect over the real one. The decrease in market value as a result of the event may result from an increase in investors’ uncertainty as to the effects of changes in strategy and skills of the new CEO. Originality: The research is a unique one. To date, no one has carried out research into shareholders’ reaction to a CEO appointment in either the Polish or Central and Eastern European capital markets. They primarily bring the value of cognition of shareholders’ behaviour in the analysed event, which is reflected in share prices. They extend the literature on the signalization instruments, i.e. the activities that boards can undertake due to the new information transmitted to the capital market participants and stakeholders. The market reaction to a CEO appointment will without a doubt interest investors; the institutions responsible for supervision (which in the case of Poland is the Financial Oversight Commission and the legislator in charge of regulations that prevent insider trading while promoting corporate disclosure transparency.

  11. Varfarin in the complex treatment of antiphospholipid syndrome: preliminary results

    Directory of Open Access Journals (Sweden)

    T M Reshetnyak

    2003-01-01

    Full Text Available Objective. To assess efficacy and tolerance of varfarin in prophylaxis and therapy of thrombotic complications in patients with antiphospholipid syndrome (APS. Methods. 20 pts with APS (5 male and 15 female received varfarin during a year. 8 of them had primary APS (PAPS and 12 -systemic lupus erythematosus with APS (SLE+APS. 2 other pts (I with SLE+APS and I with PAPS received varfarin during the last 4 years. Nobody from 9 pts with PAPS received corticosteroids (CS. In SLE+APS pts CS dose varied from 4 to 20 mg/day and was not increased during follow up. During the study prothrombine time (PT was examined with thromboplastin ( manufactured by Renam having international sensitivity index 1,2 and international normalization relation (INR. Depending on treatment scheme APS pts were divided into 3 groups. Group 1 included 8 pts with INR<2,0, Group 2-7 with INR >3,0, group 3 - 7 pts with INR<2,0 receiving as additional treatment thrombo ASS 100 mg/day and vasonit from 600 to 1200 mg/day. Results. Two pts with INR = 1,8 had thrombosis recurrence (due to leg thrombophlebitis. There were no recurrences in other groups. 2 from 22 pts had "large" bleedings. "Small" bleedings episodes were noted in 7 from 22 pts. Largely that were subcutaneous bleedings (in 4 pts no more than 5 cm of size. Two pts receiving varfarin with INR 1,8 and 2,4 had renal colic. Conclusion. Our preliminary results prove the necessity of inclusion of varfarin in the treatment of pts with APS and thrombosis but intensive anticoagulant effect is not always desired.

  12. Preliminary results of the XR2-1 experiment

    Energy Technology Data Exchange (ETDEWEB)

    Gauntt, R.O.; Helmick, P.H. [Sandia National Labs., Albuquerque, NM (United States); Humphries, L. [SAIC, Albuquerque, NM (United States)

    1996-03-01

    The XR2-1 (Ex-Reactor) experiment, investigating metallic core-melt relocation in boiling water reactor geometry, was performed on October 12, 1995, following two previous simpler XR1-series tests in August and November of 1993. The XR2-1 test made use of a highly detailed replication of the lower region of the BWR core, including the control blade and channel box structures, fuel rods, fuel canister nosepieces, control blade velocity limiter, and fuel support pieces, in order to investigate a key core melt progression uncertainty for BWR Station Blackout type accidents. The purpose of this experiment program is to examine the behavior of downward-draining molten metallic core materials in a severe reactor accident in a dry BWR core, and to determine conditions under which the molten materials drain out of the core region, or freeze to form blockages in the lower portion of the core. In the event that the draining metallic materials do not form stable blockages in the lower core region, and instead erode the lower core structures such as the lower core plate, then the subsequent core melt progression processes may proceed quite differently than was observed in the TMI-2 accident, with correspondingly different impact on vessel loading and vessel release behavior. The results of the Ex-Reactor tests are preliminary. All of the tests conducted have shown a significant degree of channel box destruction induced by the draining control blade materials. The XR2-1 test further showed that the draining zircaloy melt causes significant disruption of the fuel rod geometry. All of the tests have shown tendencies to form interim blockages as the melts temporarily freeze, but that these blockages re-melt, assisted by eutectic interactions, resulting in the sudden draining of accumulated metallic melt pools.

  13. Advancements in brachytherapy.

    Science.gov (United States)

    Tanderup, Kari; Ménard, Cynthia; Polgar, Csaba; Lindegaard, Jacob Christian; Kirisits, Christian; Pötter, Richard

    2017-01-15

    Brachytherapy is a radiotherapy modality associated with a highly focal dose distribution. Brachytherapy treats the cancer tissue from the inside, and the radiation does not travel through healthy tissue to reach the target as with external beam radiotherapy techniques. The nature of brachytherapy makes it attractive for boosting limited size target volumes to very high doses while sparing normal tissues. Significant developments over the last decades have increased the use of 3D image guided procedures with the utilization of CT, MRI, US and PET. This has taken brachytherapy to a new level in terms of controlling dose and demonstrating excellent clinical outcome. Interests in focal, hypofractionated and adaptive treatments are increasing, and brachytherapy has significant potential to develop further in these directions with current and new treatment indications. Copyright © 2016 Elsevier B.V. All rights reserved.

  14. Use of a rectal spacer with low-dose-rate brachytherapy for treatment of prostate cancer in previously irradiated patients: Initial experience and short-term results.

    Science.gov (United States)

    Mahal, Brandon A; Ziehr, David R; Hyatt, Andrew S; Neubauer-Sugar, Emily H; O'Farrell, Desmond A; O'Leary, Michael P; Steele, Graeme S; Niedermayr, Thomas R; Beard, Clair J; Martin, Neil E; Orio, Peter F; D'Amico, Anthony V; Devlin, Phillip M; Nguyen, Paul L

    2014-01-01

    Salvage brachytherapy in patients with prior pelvic radiation carries a risk of rectal injury. Herein, we report our initial experience using a hydrogel spacer between the prostate and the rectum during salvage brachytherapy. A total of 11 patients with prostate cancer and prior radiotherapy (5 prostate brachytherapy, 2 prostate external beam radiation therapy [EBRT], and 4 rectal cancer EBRT) received (125)I brachytherapy after attempted placement of 10cc of a diluted hydrogel spacer between the prostate and rectum. Spacing was achieved in 8 of the 11 (73%) patients but was not possible in 3 (1 prior brachytherapy and 2 prior EBRT) owing to fibrosis and adhesions. For the 8 patients in whom spacing was accomplished, the median space between the prostate and rectum was 10.9mm (prior EBRT) vs. 7.7mm (prior brachytherapy), p=0.048. Median followup was 15.7 months. One patient developed a prostato-rectal fistula requiring a diverting colostomy. The 16-month estimate of late Grade 3 or 4 gastrointestinal or genitourinary toxicity was 26%. One patient developed lymph node-positive recurrence. The 16-month prostate-specific antigen failure-free survival rate was 89%. Compared with baseline, Expanded Prostate Cancer Index Composite for Clinical Practice urinary quality of life (QoL) was significantly worse at 3 and 6 months but not significantly worse by 1 year. There were no significant changes throughout the study period in bowel or sexual QoL. Hydrogel spacer placements may be feasible in most patients with prior pelvic radiation. Further followup is needed to determine whether spacer placement will produce long-term improvements in toxicity or QoL. Copyright © 2014 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

  15. Treatment of Locally Advanced Vaginal Cancer With Radiochemotherapy and Magnetic Resonance Image-Guided Adaptive Brachytherapy: Dose-Volume Parameters and First Clinical Results

    Energy Technology Data Exchange (ETDEWEB)

    Dimopoulos, Johannes C.A. [Department of Radiation Oncology, Metropolitan Hospital, Athens (Greece); Schmid, Maximilian P., E-mail: maximilian.schmid@akhwien.at [Department of Radiotherapy, Medical University of Vienna, Vienna (Austria); Fidarova, Elena; Berger, Daniel; Kirisits, Christian; Poetter, Richard [Department of Radiotherapy, Medical University of Vienna, Vienna (Austria)

    2012-04-01

    Purpose: To investigate the clinical feasibility of magnetic resonance image-guided adaptive brachytherapy (IGABT) for patients with locally advanced vaginal cancer and to report treatment outcomes. Methods and Materials: Thirteen patients with vaginal cancer were treated with external beam radiotherapy (45-50.4 Gy) plus IGABT with or without chemotherapy. Distribution of International Federation of Gynecology and Obstetrics stages among patients were as follows: 4 patients had Stage II cancer, 5 patients had Stage III cancer, and 4 patients had Stage IV cancer. The concept of IGABT as developed for cervix cancer was transferred and adapted for vaginal cancer, with corresponding treatment planning and reporting. Doses were converted to the equivalent dose in 2 Gy, applying the linear quadratic model ({alpha}/{beta} = 10 Gy for tumor; {alpha}/{beta} = 3 for organs at risk). Endpoints studied were gross tumor volume (GTV), dose-volume parameters for high-risk clinical target volume (HRCTV), and organs at risk, local control (LC), adverse side effects, and survival. Results: The mean GTV ({+-} 1 standard deviation) at diagnosis was 45.3 ({+-}30) cm{sup 3}, and the mean GTV at brachytherapy was 10 ({+-}14) cm{sup 3}. The mean D90 for the HRCTV was 86 ({+-}13) Gy. The mean D2cc for bladder, urethra, rectum, and sigmoid colon were 80 ({+-}20) Gy, 76 ({+-}16) Gy, 70 ({+-}9) Gy, and 60 ({+-}9) Gy, respectively. After a median follow-up of 43 months (range, 19-87 months), one local recurrence and two distant metastases cases were observed. Actuarial LC and overall survival rates at 3 years were 92% and 85%. One patient with Stage IVA and 1 patient with Stage III disease experienced fistulas (one vesicovaginal, one rectovaginal), and 1 patient developed periurethral necrosis. Conclusions: The concept of IGABT, originally developed for treating cervix cancer, appears to be applicable to vaginal cancer treatment with only minor adaptations. Dose-volume parameters for HRCTV and

  16. In vivo dosimetry HDR brachytherapy prostate with source CO-60: Results of measures in a point urethra; Dosimetria in vivo en braquiterapia HDR de prostate con fuente de CO-60: Resultados de medidas en un punto de uretra

    Energy Technology Data Exchange (ETDEWEB)

    Latorre, D.; Fernandez, J.; Rivero, G.; Crelgo, D.; Gonzalez, J. M.; Sanchez, P.; Villace, A.; Sanchez, E.; Arroyo, M. A.; Garcia, E.; Trabanco, E.

    2015-07-01

    In this study we present and analyze the results of the in vivo dosimetry made a point of urethra with a group of 30 patients treated with brachytherapy prostate high rate with Co-60 source. Taking into account the uncertainties, the results and integration, globally evaluate this system DIV. This DIV system, due to its ease of calibration and use, and provides a relatively simple integration way to avoid serious errors in administering treatment. (Author)

  17. Mapping Antarctica using Landsat-8 - the preliminary results

    Science.gov (United States)

    Cheng, X.; Hui, F.; Qi, X.

    2014-12-01

    The first Landsat Image Mosaic of Antarctica (LIMA) was released in 2009, which was created by USGS, BAS, and NASA from more than 1,000 Landsat ETM+ scenes. As the first major scientific outcome of the IPY, LIMA supports current scientific polar research, encourages new projects, and helps the general public visualize Antarctica and changes happening to this southernmost environment. As the latest satellite of Landsat mission, the Landsat-8 images the entire Earth every 16 days in an 8-day offset from Landsat-7. Data collected by the instruments onboard the satellite are available to download at no charge within 24 hours of reception. The standard Landsat 8 products provided by the USGS EROS Center consist of quantized and calibrated scaled Digital Numbers (DN) in 16-bit unsigned integer format and can be rescaled to the Top Of Atmosphere (TOA) reflectance and/or radiance. With the support of USGS portal, we searched and downloaded more than 1600 scenes of Level 1 T- Terrain Corrected Landsat 8 image products covering Antarctica from late 2013 to early 2014. These data were converted to planetary radiance for further processing. Since the distribution of clouds in these images are random and much complicated, statistics on the distribution of clouds were performed and then help to decide masking those thicker cloud to keep more useful information left and avoid observation holes. A preliminary result of the Landsat-8 mosaic of Antarctica under the joint efforts of Beijing Normal University, NSIDC and University of Maryland will be released on this AGU fall meeting. Comparison between Landsat 7 and 8 mosaic products will also be done to find the difference or advantage of the two products.

  18. Intraspecific variability of European larch for wood properties: Preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Paques, L.E.; Rozenberg, P. [Institut National de Recherches Agronomiques (INRA), 45 - Olivet (France). Station d`Amelioration des Arbres Forestiers

    1995-12-31

    Wood properties of several natural populations of European larch (Larix decidua Mill) were determined from samples collected in one replicate of the II. International IUFRO provenance experiment, planted in Brittany in 1959. According to provenances, proportion of heartwood ranges from 35 to 58% of basal area, basic density from 442 to 505 g/dm{sup 3} and Young modulus of elasticity from 8474 to 14522 MPa. Positive correlations between girth and heartwood proportion and between wood density and modulus of elasticity but negative correlations between ring width and both density and MOE have been found both at the individual and at the population levels. Variability between and within provenances is high for two major traits (proportion of heartwood and Young modulus of elasticity) for which a SW - NE gradient is shown. For wood density parameters including pilodyn, a greater homogeneity is observed. Besides a now largely recognized superiority for growth traits, Central European populations from the Sudetan Mountains and Central Poland would also produce wood with better properties. On the reverse, Alpine populations from the French Alps growing at low elevations have a slower growth, a denser wood with less heartwood and less strength. Used as a control, the hybrid larch origin (Larix x eurolepis) represents the best compromise for wood properties with the highest strength but an average wood density and one of the highest proportion of heartwood. These preliminary results must be confirmed from a larger set of provenances and completed with other major wood properties such as durability and shrinkage. 17 refs, 2 figs, 6 tabs

  19. New method of scoliosis assessment: preliminary results using computerized photogrammetry.

    Science.gov (United States)

    Aroeira, Rozilene Maria Cota; Leal, Jefferson Soares; de Melo Pertence, Antônio Eustáquio

    2011-09-01

    A new method for nonradiographic evaluation of scoliosis was independently compared with the Cobb radiographic method, for the quantification of scoliotic curvature. To develop a protocol for computerized photogrammetry, as a nonradiographic method, for the quantification of scoliosis, and to mathematically relate this proposed method with the Cobb radiographic method. Repeated exposure to radiation of children can be harmful to their health. Nevertheless, no nonradiographic method until now proposed has gained popularity as a routine method for evaluation, mainly due to a low correspondence to the Cobb radiographic method. Patients undergoing standing posteroanterior full-length spine radiographs, who were willing to participate in this study, were submitted to dorsal digital photography in the orthostatic position with special surface markers over the spinous process, specifically the vertebrae C7 to L5. The radiographic and photographic images were sent separately for independent analysis to two examiners, trained in quantification of scoliosis for the types of images received. The scoliosis curvature angles obtained through computerized photogrammetry (the new method) were compared to those obtained through the Cobb radiographic method. Sixteen individuals were evaluated (14 female and 2 male). All presented idiopathic scoliosis, and were between 21.4 ± 6.1 years of age; 52.9 ± 5.8 kg in weight; 1.63 ± 0.05 m in height, with a body mass index of 19.8 ± 0.2. There was no statistically significant difference between the scoliosis angle measurements obtained in the comparative analysis of both methods, and a mathematical relationship was formulated between both methods. The preliminary results presented demonstrate equivalence between the two methods. More studies are needed to firmly assess the potential of this new method as a coadjuvant tool in the routine following of scoliosis treatment.

  20. A Novel Form of Breast Intraoperative Radiation Therapy With CT-Guided High-Dose-Rate Brachytherapy: Results of a Prospective Phase 1 Clinical Trial

    Energy Technology Data Exchange (ETDEWEB)

    Showalter, Shayna L., E-mail: snl2t@virginia.edu [Division of Surgical Oncology, Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia (United States); Petroni, Gina [Division of Translation Research and Applied Statistics, Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia (United States); Trifiletti, Daniel M.; Libby, Bruce [Department of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, Virginia (United States); Schroen, Anneke T.; Brenin, David R. [Division of Surgical Oncology, Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia (United States); Dalal, Parchayi [Department of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, Virginia (United States); Smolkin, Mark [Division of Translation Research and Applied Statistics, Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia (United States); Reardon, Kelli A.; Showalter, Timothy N. [Department of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, Virginia (United States)

    2016-09-01

    Purpose: Existing intraoperative radiation therapy (IORT) techniques are criticized for the lack of image guided treatment planning and energy deposition with, at times, poor resultant dosimetry and low radiation dose. We pioneered a novel method of IORT that incorporates customized, computed tomography (CT)-based treatment planning and high-dose-rate (HDR) brachytherapy to overcome these drawbacks: CT-HDR-IORT. Methods and Materials: A phase 1 study was conducted to demonstrate the feasibility and safety of CT-HDR-IORT. Eligibility criteria included age ≥50 years, invasive or in situ breast cancer, tumor size <3 cm, and N0 disease. Patients were eligible before or within 30 days of breast-conserving surgery (BCS). BCS was performed, and a multilumen balloon catheter was placed. CT images were obtained, a customized HDR brachytherapy plan was created, and a dose of 12.5 Gy was delivered to 1-cm depth from the balloon surface. The catheter was removed, and the skin was closed. The primary endpoints were feasibility and acute toxicity. Feasibility was defined as IORT treatment interval (time from CT acquisition until IORT completion) ≤90 minutes. The secondary endpoints included dosimetry, cosmetic outcome, quality of life, and late toxicity. Results: Twenty-eight patients were enrolled. The 6-month follow-up assessments were completed by 93% of enrollees. The median IORT treatment interval was 67.2 minutes (range, 50-108 minutes). The treatment met feasibility criteria in 26 women (93%). The dosimetric goals were met in 22 patients (79%). There were no Radiation Therapy Oncology Group grade 3+ toxicities; 6 patients (21%) experienced grade 2 events. Most patients (93%) had good/excellent cosmetic outcomes at the last follow-up visit. Conclusions: CT-HDR-IORT is feasible and safe. This promising approach for a conformal, image-based, higher-dose breast IORT is being evaluated in a phase 2 trial.

  1. Resultados de la aplicación de braquiterapia en el melanoma de coroides Results of the use of brachytherapy in choroidal melanoma

    Directory of Open Access Journals (Sweden)

    Belmary Aragonés Cruz

    2006-12-01

    Full Text Available Con el objetivo de evaluar los resultados a largo plazo de la braquiterapia con implante epiescleral de iridio 192 en el melanoma de coroides, se realizó un estudio clínico retrospectivo-prospectivo, que abarcó un período de 10 años, cuyo universo estuvo constituido por 30 ojos de 30 pacientes (cada uno de ellos aportó un ojo. Como resultado se observó una reducción del volumen tumoral en el 96,6 % de los casos. Conservó o mejoró la visión en 63,3 % de los casos. El desprendimiento de retina y el glaucoma neovascular fueron las complicaciones más frecuentes. Se detectó metástasis en 3,3 % de los casos, relacionados con el tumor, pero no se detectaron fallecimientos. Solo 13,3 % requirió enucleación por recaída. Por lo cual se pudo concluir que la braquiterapia con iridio 192 constituye una variante terapéutica y eficaz, con buenos resultados de supervivencia (100 %, de conservación del globo ocular y de la agudeza visual, que ofrece al paciente mejor calidad de vidaWith the objective of assessing the long-term results of episcleral iridium-192 implant brachytherapy for choroidal melanoma, a prospective/retrospective clinical study was performed, which covered 30 eyes for a period of 10 years. As a consequence, a reduction of the tumor volume was observed in 95,6 % of cases, Vision was preserved or improved in 63,3 % of treated eyes. Retinal detachment and neovascular glaucoma were the most frequent complications. Metastasis was detected in 3,3 % but no one died. Only 13,3 % required enucleation due to a relapse. It was concluded that iridium-102 brachytherapy constitutes an efficient therapeutic variant, with good results in survival (100%, and eye ball and visual acuity preservation, which provides the patient with better quality of life

  2. Mycodiversity in marine sediments contaminated by heavy metals: preliminary results

    Science.gov (United States)

    Zotti, Mirca; Carbone, Cristina; Cecchi, Grazia; Consani, Sirio; Cutroneo, Laura; Di Piazza, Simone; Gabutto, Giacomo; Greco, Giuseppe; Vagge, Greta; Capello, Marco

    2016-04-01

    .6 CFU per gram of sediments. The maximum value of 11 CFU g-1 has been recorded in two stations (off the Sestri Levante Tombolo), while the minimum value has been recorded closer to the coast. As concern qualitative results, the most recurrent genera are Aspergillus and Penicillium. These data confirm the occurrence of a mycobiota in these heavy metal contaminated sediments. Our preliminary results are a first contribution to the knowledge of presence of microfungi in marine sediments, and propel us to increase our research in order to find out new organisms for bioremediation purpose.

  3. Preliminary Results to Support Evidence of Thermospheric Contraction

    Science.gov (United States)

    Saunders, A.; Swinerd, G.; Lewis, H.

    Atmospheric density has an important influence in predicting the positions of satellites in low Earth orbit. For long-term predictions of satellite ephemerides, any density trend in the thermosphere would be a valuable input, not only to satellite operators, but also to studies of the future low Earth orbit environment in terms of space debris. A secular thermospheric density trend has not yet been definitively proven but predictions by Ramesh and Roble [1], along with evidence by Emmert et al. [2], strongly suggest the existence of such a phenomenon. With the ultimate goal of deriving a long-term empirical model of thermospheric cooling and contraction, the primary focus of this paper is to present preliminary results obtained to support the existing evidence for such a thermospheric contraction. There are many ways of determining atmospheric density, but inferring thermospheric density from satellite drag data is a relatively cost-effective way of gathering in-situ measurements. Given an initial satellite orbit, one approach is to use an orbital propagator to predict the satellite's state at some time ahead and then to compare that state with Two-Line Element (TLE) data at the same epoch. The difference between the semi-major axis of the satellite from the initial orbit and that after the orbit propagation is then integrated to obtain an estimate of global average density. This is the approach adopted in our new work, using a bespoke, orbital propagator that includes perturbations due to atmospheric drag, gravitational anomalies, luni-solar gravity effects and solar radiation pressure. The methods used to derive precise estimates of the ballistic coefficient of each satellite for use in the propagator are outlined, as this information is not contained explicitly in the TLE sets. In validation of the orbital propagator used in this study, Saunders et al. [3] ran simulations to predict satellite re-entry dates with satisfactory results. Now, historical satellite

  4. Preliminary results of the PREFER FP7 Project

    Science.gov (United States)

    Fusilli, Lorenzo; Laneve, Giovanni; De Bonis, Roberto; Sebastian, Ana; Ferrucci, Fabrizio; Oliveira, Sandra

    2014-05-01

    The need to improve the information and intelligence support for forest fire prevention is widely recognized. Fire prevention is still the most cost-effective strategy when compared to firefighting and extinguishing that are costly, local, and triggered only in response to already ongoing crises. PREFER project, funded under the EU FP7 (G.A. 312931), intends to contribute at responding to such a pragmatic need of southern Europe's forests by: providing timely information products based on the exploitation of all available spacecraft sensors, offering a portfolio of products focused on pre- and post-crisis forest fire emergency, suitable for the users in the different countries of the European Mediterranean area. The PREFER Service portfolio consists of two main services: 1. Information Support to Fire Preparedness/Prevention Phase" (ISP) Service 2. Information Support to Fire Recovery/Reconstruction Phase" (ISR) Service This service is already at an advanced stage having completed the first year of activity. During this time several products have been consolidated: seasonal fuel maps; daily and seasonal fire hazard maps; seasonal risk maps; prescribed fire maps. This paper aims at presenting the preliminary results of the research activity carried out in the framework of the PREFER project, focusing, in particular, on these recalled above. As for Fire Risk and Hazard assessment, many indexes have been developed in the last years. Hardly any of them uses data derived from satellite images. The FPI index is an exception to this rule which, in addition, makes use of meteorological data. In spite of being a very complete index, the FPI still allows room for improvement which justify the interest of PREFER in it. PREFER's innovative approach to FPI will allow taking into account the effect of solar illumination conditions in determining the humidity present in the dead vegetation, and therefore its proneness to burn. PREFER innovation also focus in allowing the index to

  5. Metabolic syndrome in rheumatoid arthritis: role of adiponectin (preliminary results

    Directory of Open Access Journals (Sweden)

    Yulia Nikolaevna Gorbunova

    2013-01-01

    were encountered with the same frequency in early- and end-stage RA. The early RA group showed a correlation between SDAI (r = -0.34, body mass index (r = -0.41, high-density lipoprotein cholesterol (r = 0.33, erythrocyte sedimentation rate (r =-0.35, and adiponectin. The >2-year RA group displayed no relationship between adipokins, activity markers, and metabolic disturbances. Conclusion. The preliminary results suggest the high rate of MS in patients with a high level of early RA disease activity untreated with disease-modifying antirheumatic drugs, thus determining the high risk of CVEs just at disease onset. The role of adiponectin in the development of MS, CVEs in rheumatic diseases remains to be solved, which is the subject of further investigations. It is possible that normalization of adiponectin concentrations may promote reductions in the incidence of CVD, mortality rates due to atherosclerosis-induced CVEs, and the prevalence of MS and insulin resistance.

  6. WISE/NEOWISE Observations of the Hilda Population: Preliminary Results

    OpenAIRE

    Grav, T.; Mainzer, A. K.; Bauer, J.; Masiero, J.; Spahr, T.; McMillan, R. S.; Walker, R; Cutri, R.; Wright, E.; Eisenhardt, P. R.; Blauvelt, E.; DeBaun, E.; Elsbury, D; Gautier IV, T.; Gomillion, S.

    2012-01-01

    We present the preliminary analysis of 1023 known asteroids in the Hilda region of the Solar System observed by the NEOWISE component of the Wide-field Infrared Survey Explorer (WISE). The sizes of the Hildas observed range from $\\sim 3 - 200$km. We find no size - albedo dependency as reported by other projects. The albedos of our sample are low, with a weighted mean value $p_V = 0.055\\pm0.018$, for all sizes sampled by the NEOWISE survey. We observed a significant fraction of the objects in ...

  7. 78 FR 20890 - Polyvinyl Alcohol From Taiwan: Preliminary Results of Antidumping Duty Administrative Review...

    Science.gov (United States)

    2013-04-08

    ... International Trade Administration Polyvinyl Alcohol From Taiwan: Preliminary Results of Antidumping Duty... the antidumping duty order on polyvinyl alcohol (PVA) from Taiwan. The period of review (POR) is... Memorandum for Preliminary Results of Antidumping Duty Administrative Review: Polyvinyl Alcohol from Taiwan...

  8. Complete response of endemic Kaposi sarcoma lesions with high-dose-rate brachytherapy: treatment method, results, and toxicity using skin surface applicators.

    Science.gov (United States)

    Kasper, Michael E; Richter, Sam; Warren, Nicholas; Benda, Rashmi; Shang, Charles; Ouhib, Zoubir

    2013-01-01

    To analyze the clinical outcome of Kaposi sarcoma skin lesions treated with high-dose-rate (HDR) brachytherapy in patients with a minimum of 2 years of followup. Between February 2006 and July 2008, all patients with Kaposi sarcoma who received (192)Ir HDR brachytherapy using a skin surface applicator were evaluated for clinical response. Responses to treatment and toxicity were scored using standard criteria. Sixteen cases were collected. Treatment was delivered in four to six fractions, over a period of approximately 12 days. The specified dose ranged from 24 to 35Gy. Median followup the lesion was 41.4 months. No lesion was greater than 2cm. All patients had a complete response to treatment, with no evidence of local recurrence or tumor progression. Thirteen lesions developed Grade 1 and two lesions had Grade 2 acute skin reactions. One patient developed late skin changes with telangiectasias and hypopigmentation. HDR brachytherapy treatment seems to be an effective noninvasive option for patients with small cutaneous Kaposi sarcoma lesions, delivering excellent cosmesis and local control in our small series. Fewer fractions over a shorter period used in our group offer patients more convenience compared with other common regimens. Although HDR is being used more frequently for many surface applications, additional clinical studies with larger numbers of patients and longer followup are needed to confirm the general impression that it is an excellent option for many patients. Copyright © 2013 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

  9. Single-fraction high-dose-rate brachytherapy and hypofractionated external beam radiation therapy in the treatment of intermediate-risk prostate cancer - long term results.

    Science.gov (United States)

    Cury, Fabio L; Duclos, Marie; Aprikian, Armen; Patrocinio, Horacio; Kassouf, Wassim; Shenouda, George; Faria, Sergio; David, Marc; Souhami, Luis

    2012-03-15

    We present the long-term results of a cohort of patients with intermediate-risk prostate cancer (PC) treated with single-fraction high-dose-rate brachytherapy (HDRB) combined with hypofractionated external beam radiation therapy (HypoRT). Patients were treated exclusively with HDRB and HypoRT. HDRB delivered a dose of 10 Gy to the prostate surface and HypoRT consisted of 50 Gy delivered in 20 daily fractions. The first 121 consecutive patients with a minimum of 2 years posttreatment follow-up were assessed for toxicity and disease control. The median follow-up was 65.2 months. No acute Grade III or higher toxicity was seen. Late Grade II gastrointestinal toxicity was seen in 9 patients (7.4%) and Grade III in 2 (1.6%). Late Grade III genitourinary toxicity was seen in 2 patients (1.6%). After a 24-month follow-up, a rebiopsy was offered to the first 58 consecutively treated patients, and 44 patients agreed with the procedure. Negative biopsies were found in 40 patients (91%). The 5-year biochemical relapse-free survival rate was 90.7% (95% CI, 84.5-96.9%), with 13 patients presenting biochemical failure. Among them, 9 were diagnosed with distant metastasis. Prostate cancer-specific and overall survival rates at 5 years were 100% and 98.8% (95% CI, 96.4-100%), respectively. The combination of HDRB and HypoRT is well tolerated, with acceptable toxicity rates. Furthermore, results from rebiopsies revealed an encouraging rate of local control. These results confirm that the use of conformal RT techniques, adapted to specific biological tumor characteristics, have the potential to improve the therapeutic ratio in intermediate-risk PC patients. Copyright © 2012 Elsevier Inc. All rights reserved.

  10. 78 FR 7395 - Stainless Steel Bar From India: Preliminary Results of Antidumping Duty Administrative Review...

    Science.gov (United States)

    2013-02-01

    ... International Trade Administration Stainless Steel Bar From India: Preliminary Results of Antidumping Duty... the antidumping duty order on stainless steel bar (SSB) from India. The period of review (POR) is... Review: Stainless Steel Bar from India'' dated concurrently with this notice (``Preliminary Decision...

  11. 78 FR 78335 - Lightweight Thermal Paper from Germany: Preliminary Results of Antidumping Duty Administrative...

    Science.gov (United States)

    2013-12-26

    ... Duty Administrative Review; 2011-2012 AGENCY: Enforcement and Compliance, formerly Import... Preliminary Decision Memorandum are identical in content. Preliminary Results of the Review \\2\\ \\2\\ As... calculate an importer-specific ad valorem ratio based on the estimated entered value. We will instruct CBP...

  12. Seismic Hazard Maps for the Maltese Archipelago: Preliminary Results

    Science.gov (United States)

    D'Amico, S.; Panzera, F.; Galea, P. M.

    2013-12-01

    The Maltese islands form an archipelago of three major islands lying in the Sicily channel at about 140 km south of Sicily and 300 km north of Libya. So far very few investigations have been carried out on seismicity around the Maltese islands and no maps of seismic hazard for the archipelago are available. Assessing the seismic hazard for the region is currently of prime interest for the near-future development of industrial and touristic facilities as well as for urban expansion. A culture of seismic risk awareness has never really been developed in the country, and the public perception is that the islands are relatively safe, and that any earthquake phenomena are mild and infrequent. However, the Archipelago has been struck by several moderate/large events. Although recent constructions of a certain structural and strategic importance have been built according to high engineering standards, the same probably cannot be said for all residential buildings, many higher than 3 storeys, which have mushroomed rapidly in recent years. Such buildings are mostly of unreinforced masonry, with heavy concrete floor slabs, which are known to be highly vulnerable to even moderate ground shaking. We can surely state that in this context planning and design should be based on available national hazard maps. Unfortunately, these kinds of maps are not available for the Maltese islands. In this paper we attempt to compute a first and preliminary probabilistic seismic hazard assessment of the Maltese islands in terms of Peak Ground Acceleration (PGA) and Spectral Acceleration (SA) at different periods. Seismic hazard has been computed using the Esteva-Cornell (1968) approach which is the most widely utilized probabilistic method. It is a zone-dependent approach: seismotectonic and geological data are used coupled with earthquake catalogues to identify seismogenic zones within which earthquakes occur at certain rates. Therefore the earthquake catalogues can be reduced to the

  13. Dynamic rotating-shield brachytherapy

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Yunlong [Department of Electrical and Computer Engineering, University of Iowa, 4016 Seamans Center, Iowa City, Iowa 52242 (United States); Flynn, Ryan T.; Kim, Yusung [Department of Radiation Oncology, University of Iowa, 200 Hawkins Drive, Iowa City, Iowa 52242 (United States); Yang, Wenjun [Department of Medical Physics, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, Wisconsin 53705 (United States); Wu, Xiaodong [Department of Electrical and Computer Engineering, University of Iowa, 4016 Seamans Center, Iowa City, Iowa 52242 and Department of Radiation Oncology, University of Iowa, 200 Hawkins Drive, Iowa City, Iowa 52242 (United States)

    2013-12-15

    Purpose: To present dynamic rotating shield brachytherapy (D-RSBT), a novel form of high-dose-rate brachytherapy (HDR-BT) with electronic brachytherapy source, where the radiation shield is capable of changing emission angles during the radiation delivery process.Methods: A D-RSBT system uses two layers of independently rotating tungsten alloy shields, each with a 180° azimuthal emission angle. The D-RSBT planning is separated into two stages: anchor plan optimization and optimal sequencing. In the anchor plan optimization, anchor plans are generated by maximizing the D{sub 90} for the high-risk clinical-tumor-volume (HR-CTV) assuming a fixed azimuthal emission angle of 11.25°. In the optimal sequencing, treatment plans that most closely approximate the anchor plans under the delivery-time constraint will be efficiently computed. Treatment plans for five cervical cancer patients were generated for D-RSBT, single-shield RSBT (S-RSBT), and {sup 192}Ir-based intracavitary brachytherapy with supplementary interstitial brachytherapy (IS + ICBT) assuming five treatment fractions. External beam radiotherapy doses of 45 Gy in 25 fractions of 1.8 Gy each were accounted for. The high-risk clinical target volume (HR-CTV) doses were escalated such that the D{sub 2cc} of the rectum, sigmoid colon, or bladder reached its tolerance equivalent dose in 2 Gy fractions (EQD2 with α/β= 3 Gy) of 75 Gy, 75 Gy, or 90 Gy, respectively.Results: For the patients considered, IS + ICBT had an average total dwell time of 5.7 minutes/fraction (min/fx) assuming a 10 Ci{sup 192}Ir source, and the average HR-CTV D{sub 90} was 78.9 Gy. In order to match the HR-CTV D{sub 90} of IS + ICBT, D-RSBT required an average of 10.1 min/fx more delivery time, and S-RSBT required 6.7 min/fx more. If an additional 20 min/fx of delivery time is allowed beyond that of the IS + ICBT case, D-RSBT and S-RSBT increased the HR-CTV D{sub 90} above IS + ICBT by an average of 16.3 Gy and 9.1 Gy, respectively

  14. A prospective cohort study to compare treatment results between 2 fractionation schedules of high-dose-rate intracavitary brachytherapy (HDR-ICBT) in patients with cervical cancer.

    Science.gov (United States)

    Huang, Eng-Yen; Sun, Li-Min; Lin, Hao; Lan, Jen-Hong; Chanchien, Chan-Chao; Huang, Yu-Jie; Wang, Chang-Yu; Wang, Chong-Jong

    2013-01-01

    To compare the treatment results of 2 fractionation schedules for high-dose-rate intracavitary brachytherapy (HDR-ICBT) in patients with cervical cancer. From June 2001 through January 2008, 267 patients with stage IB-IVA cervical cancer were enrolled in the study. All patients underwent 4-field pelvic irradiation and HDR-ICBT. The median central and parametrial doses were 39.6 Gy and 45 Gy, respectively. Patient underwent either 6 Gy×4 (HDR-4) (n=144) or 4.5 Gy×6 (HDR-6) (n=123) to point A of ICBT using 192Ir isotope twice weekly. The rates of overall survival, locoregional failure, distant metastasis, proctitis, cystitis, and enterocolitis were compared between HDR-4 and HDR-6. There were no significant differences in the demographic data between HDR-4 and HDR-6 except for total treatment time. The 5-year proctitis rates were 23.0% and 21.5% in HDR-4 and HDR-6 (P=.399), respectively. The corresponding rates of grade 2-4 proctitis were 18.7% and 9.6% (P=.060). The corresponding rates of grades 3-4 proctitis were 5.2% and 1.3% (P=.231). Subgroup analysis revealed that HDR-4 significantly increased grade 2-4 proctitis in patients aged≥62 years old (P=.012) but not in patients agedschedules. The small fraction size of HDR-ICBT is associated with grade 2 proctitis without compromise of prognosis in elderly patients. This schedule is suggested for patients who tolerate an additional 2 applications of HDR-ICBT. Copyright © 2013 Elsevier Inc. All rights reserved.

  15. Updated results of high-dose rate brachytherapy and external beam radiotherapy for locally and locally advanced prostate cancer using the RTOG-ASTRO phoenix definition

    Directory of Open Access Journals (Sweden)

    Antonio C. Pellizzon

    2008-06-01

    Full Text Available PURPOSE: To evaluate the prognostic factors for patients with local or locally advanced prostate cancer treated with external beam radiotherapy (RT and high dose rate brachytherapy (HDR according to the RTOG-ASTRO Phoenix Consensus Conference. MATERIALS AND METHODS: The charts of 209 patients treated between 1997 and 2005 with localized RT and HDR as a boost at the Department of Radiation Oncology, AC Camargo Hospital, Sao Paulo, Brazil were reviewed. Clinical and treatment parameters i.e.: patient's age, Gleason score, clinical stage, initial PSA (iPSA, risk group (RG for biochemical failure, doses of RT and HDR were evaluated. Median age and median follow-up time were 68 and 5.3 years, respectively. Median RT and HDR doses were 45 Gy and 20 Gy. RESULTS: Disease specific survival (DSS at 3.3 year was 94.2%. Regarding RG, for the LR (low risk, IR (intermediate risk and HR (high risk, the DSS rates at 3.3 years were 91.5%, 90.2% and 88.5%, respectively. On univariate analysis prognostic factors related to DSS were RG (p = 0.040, Gleason score ≤ 6 ng/mL (p = 0.002, total dose of HDR ≥ 20 Gy (p < 0.001 On multivariate analysis the only statistical significant predictive factor for biochemical control (bNED was the RG, p < 0.001 (CI - 1.147-3.561. CONCLUSIONS: Although the radiation dose administered to the prostate is an important factor related to bNED, this could not be established with statistical significance in this group of patients. To date , in our own experience, HDR associated to RT could be considered a successful approach in the treatment of prostate cancer.

  16. [Colorectal cancer screening programme in Aragon (Spain): preliminary results].

    Science.gov (United States)

    Solé Llop, Mª Esther; Cano Del Pozo, Mabel; García Montero, José-Ignacio; Carrera-Lasfuentes, Patricia; Lanas, Ángel

    2017-08-04

    To describe preliminary findings from the colorectal cancer screening programme in Aragon (Spain) to evaluate its implementation. We have collected data from the first year of the program (2014) based on faecal occult blood immunochemical (FOBTi) test in patients 60-69 years old. We report "indicators" defined by the "Red Nacional de Cribado". Invited population after exclusions: 12,518. Program participation rate: 45.28% (95%CI: 44.41-46.15). Inadequate tests: 0.21% (95%CI: 0.12-0.37); positive FOBTi test 10.75% (95%CI: 9.97-11.58) and colonoscopy acceptance 95.07% (95%CI: 93.04-96.52). Colonoscopy was appropriate and complete in 97.58% (95%CI: 95.98-98.55) of cases. The high- and low-risk adenoma detection rates were 14.7‰ (95%CI: 11.9-18.2) and 5.55‰ (95%CI: 3.9-7.8) respectively. The positive predictive value for any adenoma was 58.55% (95%CI: 54.49-62.49) and for invasive cancer was 5.36% (95%CI: 3.8-7.51). The indicator analysis of the ongoing programme suggests the programme is being implemented correctly in our community. Copyright © 2017 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

  17. WISE/NEOWISE OBSERVATIONS OF THE HILDA POPULATION: PRELIMINARY RESULTS

    Energy Technology Data Exchange (ETDEWEB)

    Grav, T. [Department of Physics and Astronomy, Johns Hopkins University, Baltimore, MD 21218 (United States); Mainzer, A. K.; Bauer, J.; Masiero, J.; Eisenhardt, P. R.; Blauvelt, E.; DeBaun, E.; Elsbury, D.; Gautier, T.; Gomillion, S.; Hand, E.; Wilkins, A. [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Spahr, T. [Minor Planet Center, Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); McMillan, R. S. [Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 85721 (United States); Walker, R. [Monterey Institute for Research in Astronomy, Marina, CA 93933 (United States); Cutri, R. [Infrared Processing and Analysis Center, California Institute of Technology, Pasadena, CA 91125 (United States); Wright, E., E-mail: tgrav@pha.jhu.edu [UCLA Astronomy, Los Angles, CA 90095 (United States)

    2012-01-10

    We present the preliminary analysis of 1023 known asteroids in the Hilda region of the solar system observed by the NEOWISE component of the Wide-field Infrared Survey Explorer (WISE). The sizes of the Hildas observed range from {approx}3 to 200 km. We find no size-albedo dependency as reported by other projects. The albedos of our sample are low, with a weighted mean value of p{sub V} = 0.055 {+-} 0.018, for all sizes sampled by the NEOWISE survey. We observed a significant fraction of the objects in the two known collisional families in the Hilda population. It is found that the Hilda collisional family is brighter, with a weighted mean albedo of p{sub V} = 0.061 {+-} 0.011, than the general population and dominated by D-type asteroids, while the Schubart collisional family is darker, with a weighted mean albedo of p{sub V} = 0.039 {+-} 0.013. Using the reflected sunlight in the two shortest WISE bandpasses, we are able to derive a method for taxonomic classification of {approx}10% of the Hildas detected in the NEOWISE survey. For the Hildas with diameter larger than 30 km, there are 67{sup +7}{sub -15}% D-type asteroids and 26{sup +17}{sub -5%} C-/P-type asteroids (with the majority of these being P-types).

  18. Preliminary results for oil on the bottom detection technologies

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, K.A. [United States Coast Guard, Groton, CT (United States). Research and Development Center

    2008-07-01

    This paper addressed the challenge of finding and recovering spills of submerged oil using current methods that often prove to be inadequate. The United States Coast Guard has launched a multi-year project to develop a complete approach for spills of submerged oils. This paper described the preliminary assessment of using sonar, laser fluorometry, real-time mass spectrometry and in-situ fluorometry to locate submerged oil. Specifications for the various techniques were also described. The authors noted that the sensors should provide enough information so that decision-makers could determine if an amount of oil sufficient to merit recovering could be identified. The systems chosen for testing for this paper were the RESON multi-beam sonar system; the Science Laser Line Scan System (LLSS) adapted for fluorescence and developed by Applications International Corporation (SAIC); fluorescence polarization developed by EIC Laboratories; and in-situ mass spectrometry and in-situ fluorometry developed by Wood Hole Oceanographic Institute (WHOI). Each of these technologies represented an improvement over the existing ad-hoc methods. Although they have not been tested in harsh environments, they may be useful immediately in some situations to increase reliability of oil detection at the bottom of, or in the water column. 16 refs., 1 tab., 20 figs.

  19. Annoyance Caused by Propeller Airplane Flyover Noise: Preliminary Results

    Science.gov (United States)

    Mccurdy, D. A.; Powell, C. A.

    1981-01-01

    The annoyance response of people to the noise of propeller airplane flyovers was examined. The specific items of interest were: (1) the annoyance prediction ability of current noise metrics; (2) the effect of tone corrections on prediction ability; (3) the effect of duration corrections on prediction ability; and (4) the effect of 'critical band' corrections on the prediction ability of perceived noise level. Preliminary analyses of the data obtained from two experiments are presented. The first experiment examined 11 propeller airplanes with maximum takeoff weights greater than or equal to 5700 kg. The second experiment examined 14 propeller airplanes weighting 5700 kg or less. Also included in each experiment were five different commercial service jet airplanes. Each airplane noise was presented at D-weighted sound pressure levels of 70, 80, and 90 dB to subjects in a testing room which simulates the outdoor acoustic environment. Subjects judged 108 stimuli in the first experiment and 132 stimuli in the second experiment. Perceived noise level predicted annoyance better than A, D, or E-weighted sound pressure level. Corrections for tones greater than of equal to 500 Hz generally improved prediction ability for the heavier propeller airplanes.

  20. FDG-PET of autoimmune-related pancreatitis: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Nakamoto, Yuji; Saga, Tsuneo; Ishimori, Takayoshi; Higashi, Tatsuya; Mamede, M.; Konishi, Junji [Department of Nuclear Medicine and Diagnostic Imaging, Graduate School of Medicine, Kyoto University (Japan); Okazaki, Kazuichi [Department of Endoscopy and Gastroenterology, Graduate School of Medicine, Kyoto University (Japan); Imamura, Masayuki [Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University (Japan); Sakahara, Harumi [Department of Radiology, Hamamatsu University School of Medicine (Japan)

    2000-12-01

    The purpose of this retrospective study was to elucidate the fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) findings in autoimmune-related pancreatitis (AIP), which is a reversible chronic pancreatitis with an autoimmune cause. The study group comprised six patients with clinically diagnosed AIP. After 370 MBq (10 mCi) of FDG had been injected intravenously, the abdomen and/or the whole body was scanned at 1 h post injection in all patients, and scanning was repeated at 2 h in four patients. PET findings were evaluated visually and/or semiquantitatively using the standardized uptake value (SUV). In four of the six patients, PET demonstrated intense uptake in the whole pancreas, which appeared swollen on computed tomography, and the accumulation increased with time in three patients. In one patient, intense focal uptake in the pancreatic head was observed, and the accumulation decreased over time. In the remaining patient, no abnormal accumulation in the pancreas was observed. Follow-up PET scanning after steroid therapy was performed in three patients, and intense FDG uptake was no longer observed. Our preliminary data show that AIP can cause intense FDG uptake in the pancreas. This fact, and the benign status of the condition, should be kept in mind when making a diagnosis with FDG-PET in patients with pancreatic disorders. (orig.)

  1. Preliminary results of femtosecond laser-assisted descemet stripping endothelial keratoplasty.

    NARCIS (Netherlands)

    Cheng, Y.Y.; Hendrikse, F.; Pels, E.; Wijdh, R.J.; Cleynenbreugel, H. van; Eggink, C.A.; Rij, G. van; Rijneveld, W.J.; Nuijts, R.M.

    2008-01-01

    OBJECTIVE: To evaluate the preliminary visual results of femtosecond laser-assisted Descemet stripping endothelial keratoplasty (FS-DSEK). METHODS: We prospectively analyzed results of 20 consecutive patients with Fuchs endothelial dystrophy or aphakic/pseudophakic bullous keratopathy who underwent

  2. MRI-guided brachytherapy

    Science.gov (United States)

    Tanderup, Kari; Viswanathan, Akila; Kirisits, Christian; Frank, Steven J.

    2014-01-01

    The application of MRI-guided brachytherapy has demonstrated significant growth during the last two decades. Clinical improvements in cervix cancer outcomes have been linked to the application of repeated MRI for identification of residual tumor volumes during radiotherapy. This has changed clinical practice in the direction of individualized dose administration, and mounting evidence of improved clinical outcome with regard to local control, overall survival as well as morbidity. MRI-guided prostate HDR and LDR brachytherapy has improved the accuracy of target and organs-at-risk (OAR) delineation, and the potential exists for improved dose prescription and reporting for the prostate gland and organs at risk. Furthermore, MRI-guided prostate brachytherapy has significant potential to identify prostate subvolumes and dominant lesions to allow for dose administration reflecting the differential risk of recurrence. MRI-guided brachytherapy involves advanced imaging, target concepts, and dose planning. The key issue for safe dissemination and implementation of high quality MRI-guided brachytherapy is establishment of qualified multidisciplinary teams and strategies for training and education. PMID:24931089

  3. Dosimetric audit in brachytherapy

    Science.gov (United States)

    Bradley, D A; Nisbet, A

    2014-01-01

    Dosimetric audit is required for the improvement of patient safety in radiotherapy and to aid optimization of treatment. The reassurance that treatment is being delivered in line with accepted standards, that delivered doses are as prescribed and that quality improvement is enabled is as essential for brachytherapy as it is for the more commonly audited external beam radiotherapy. Dose measurement in brachytherapy is challenging owing to steep dose gradients and small scales, especially in the context of an audit. Several different approaches have been taken for audit measurement to date: thimble and well-type ionization chambers, thermoluminescent detectors, optically stimulated luminescence detectors, radiochromic film and alanine. In this work, we review all of the dosimetric brachytherapy audits that have been conducted in recent years, look at current audits in progress and propose required directions for brachytherapy dosimetric audit in the future. The concern over accurate source strength measurement may be essentially resolved with modern equipment and calibration methods, but brachytherapy is a rapidly developing field and dosimetric audit must keep pace. PMID:24807068

  4. Magnetotelluric investigation across the Agri Valley: preliminary results.

    Science.gov (United States)

    Balasco, Marianna; Romano, Gerardo; Siniscalchi, Agata; Alfredo Stabile, Tony

    2017-04-01

    The Agri Valley is an axial zone of the Southern Apennines thrust belt chain with a strong seismogenic potential where two important energy technologies responsible for inducing/triggering seismicity are active: (1) the disposal at the Costa Molina 2 injection well of the wastewater produced during the exploitation of the biggest onshore oil field in west Europe (27 wells producing more than 80,000 barrels of crude oil per day), managed by the Eni S.p.A., and (2) the water loading and unloading operations in the Pertusillo artificial reservoir. It is recognized the possibility that the fluctuation of the water level inside the reservoir, due to the hydrological cycle for example, produces pressure perturbations at the bottom of reservoir, causing induced seismicity. Furthermore it is even more known the role of fluids in the rupture processes which could cause an increase of pore pressure specially at high rate of injection fluids and/or for the presence of weakening of preexisting faults. With the aim to better characterize and understand the physical processes involved in the observed induced/triggered seismicity, in 2016 a broadband seismic network, covering an area of about 20 km x 20 km nearby the Pertusillo Dam and Costa Molina2 well has been installed in the framework of SIR-MIUR project INSIEME (INduced Seismicity in Italy: Estimation, Monitoring, and sEismic risk mitigation) and a MagnetoTelluric (MT) survey has been performed. The MT investigation consists of 25 soundings aligned along 30 km profile oriented at about N40 direction, orthogonal with the strike of the major and noticeable geological structures and crossing both of the source that may induce/trigger seismicity. In this work, we present the preliminary 2D resistivity model which provides useful deep geophysical information for understanding the geological and structural setting of the Agri Valley. Moreover, the comparison of the resistivity model with the earthquake location as inferred from

  5. Image-guided high-dose-rate brachytherapy boost to the dominant intraprostatic lesion using multiparametric magnetic resonance imaging including spectroscopy: Results of a prospective study.

    Science.gov (United States)

    Vigneault, Eric; Mbodji, Khaly; Racine, Louis-Gabriel; Chevrette, Eric; Lavallée, Marie-Claude; Martin, André-Guy; Després, Philippe; Beaulieu, Luc

    To evaluate the long-term outcomes of image-guided high-dose-rate (HDR) brachytherapy boost to the dominant intraprostatic lesion (DIL) using multiparametric magnetic resonance imaging (MRI), including spectroscopy (MRI/magnetic resonance spectroscopy [MRS]). Between December 2009 and March 2011, 20 patients with intermediate-risk prostate cancer underwent multiparametric MRI/MRS protocol before treatment. All patients were treated with an external beam radiotherapy dose of 40 Gy, combined with an HDR brachytherapy boost of 15 Gy. Concurrently, the DIL received a boost of 18 Gy. Missing data during followup were handled with multiple imputations. The median followup was 62 months (range, 23-71 months). Six patients (31%) were classified as favorable intermediate risk and 13 patients (69%) as unfavorable intermediate risk. One patient experienced a prostate-specific antigen biochemical failure, and the 5-year biochemical failure-free survival rate was of 94.7%. The mean International Prostate Symptom Score rose from 7, with respect to baseline, to 10.42 1 month after treatment, and rapidly decreased to 6.97 after 3 months. Grade 1, 2, and 3 acute genitourinary toxicities were reported in 13 (68%), 3 (16%), and 1 (5%) patients, respectively. Grade 1 and 2 late genitourinary toxicities were reported in 9 (53%) and 3 (18%) patients, respectively. Only grade 1 acute and late gastrointestinal toxicities were reported in 4 (21%) and 3 (18%) patients, respectively. Delivering an HDR brachytherapy boost to the DIL using image-guided multiparametric MRI/MRS is feasible with good outcomes for biochemical control, acute and late toxicities, and dosimetric constraints for critical organs. Copyright © 2016 American Brachytherapy Society. All rights reserved.

  6. Carcinological results at five years of the prostate brachytherapy by iodine 125 implants. About 327 cases; Resultats carcinologiques a cinq ans de la curietherapie de prostate par implants d'iode 125. A propos de 327 cas

    Energy Technology Data Exchange (ETDEWEB)

    Peiffert, D.; Bernier, V.; Aletti, P.; Noela, A.; Marchesi, V. [Centre Alexis-Vautrin, 54 - Vandoeuvre-les-Nancy (France); Cormier, L.; Moreau, J.L. [CHU, Service d' Urologie, 54 - Nancy (France)

    2006-11-15

    The prostate brachytherapy by iodine 125 implants is reserved to patients damaged by a favourable prognosis cancer. The objective of this study is to present the carcinological results at five years in these indications with a technique keeping urethra. The achieving of a P.S.A. nadir inferior to 0.5 ng/ml is long. the technique used in this study keeping urethra and respecting the inclusion criteria recommended allows to get results as less equivalent as these ones of big series previously published with a low failure rate. (N.C.)

  7. Canadian prostate brachytherapy in 2012

    Science.gov (United States)

    Keyes, Mira; Crook, Juanita; Morris, W. James; Morton, Gerard; Pickles, Tom; Usmani, Nawaid; Vigneault, Eric

    2013-01-01

    Prostate brachytherapy can be used as a monotherapy for low- and intermediate-risk patients or in combination with external beam radiation therapy (EBRT) as a form of dose escalation for selected intermediate- and high-risk patients. Prostate brachytherapy with either permanent implants (low dose rate [LDR]) or temporary implants (high dose rate [HDR]) is emerging as the most effective radiation treatment for prostate cancer. Several large Canadian brachytherapy programs were established in the mid- to late-1990s. Prostate brachytherapy is offered in British Columbia, Alberta, Manitoba, Ontario, Quebec and New Brunswick. We anticipate the need for brachytherapy services in Canada will significantly increase in the near future. In this review, we summarize brachytherapy programs across Canada, contemporary eligibility criteria for the procedure, toxicity and prostate-specific antigen recurrence free survival (PRFS), as published from Canadian institutions for both LDR and HDR brachytherapy. PMID:23671495

  8. The Sunphotometer Airborne Validation Experiment 2012: Preliminary Results

    Science.gov (United States)

    Estellés, Victor; Marenco, Franco; Ryder, Claire L.; Campanelli, Monica; Expósito, Francisco; Solá, Yolanda; Segura, Sara; Marcos, Carlos; Toledano, Carlos; Berjón, Alberto; Guirado, Carmen; Claxton, Bernard; Todd, Martin

    2013-04-01

    to provide detailed vertically resolved aerosol measurements, in order to compare these to sunphotometer retrievals. Simultaneously, 4 different ground AERONET - Cimel sites were deployed in the Tenerife island, at different latitudes and altitudes for further investigation of spatial and vertical variability. Three of these sites also measured solar radiation components with CM21 pyranometers and CHP1 pirheliometers, for further research on radiative forcing of aerosols. One site was equipped with a Prede POM sun-sky radiometer for comparison with Cimel sunphotometer. On the other hand, for the FENNEC campaign another AERONET Cimel sunphotometer was deployed in Zouerate (Mauritania). The ideal conditions for such a comparison consisted of cloudless skies and high mineral aerosol burdens, brought by the Saharan outflow. Although these conditions were not reached in the Tenerife area during the scheduled field campaign, appropriate conditions were met in western Mauritania, over the AERONET Zouerate site. In this study, we perform a preliminary analysis of the columnar properties of aerosols in the Canary Islands and West Sahara areas during the FENNEC 2011 and FENNEC-SAVEX 2012 field campaigns, with an emphasis on the comparison between the size distributions retrieved from both AERONET and SKYRAD algorithms using the Zouerate Cimel site data. Validation of the vertical integrated aerosol size distributions will be also presented. References - M.Campanelli, V.Estelles, T. Smyth, T. Nakajima, M. Hashimoto, A.Lupi, C. Tomas, "Retrieval of aerosol radiative properties from sun-sky radiometers measurements of ESR network: comparison between the inversion codes Skyrad4.2.pack and the new Skyrad5.pack", European Aerosol Conference, 2011. - V. Estellés, M. Campanelli, M. P. Utrillas, F. Expósito, and J. A. Martínez-Lozano, "Comparison of AERONET and SKYRAD4.2 inversion products retrieved from a Cimel CE318 sunphotometer", Atmos. Meas. Tech. 5, 569—579, 2012.

  9. 77 FR 41746 - Chlorinated Isocyanurates From the People's Republic of China: Preliminary Results of Antidumping...

    Science.gov (United States)

    2012-07-16

    ... publication of these preliminary results.\\37\\ \\37\\ In accordance with 19 CFR 351.301(c)(1), for the final... Value Memorandum. Jiheng reported chlorine, hydrogen gas, ammonia gas, and sulfuric acid as by-products...

  10. PRELIMINARY RESULTS: EVALUATIONS OF THE ALTERNATIVE ASBESTOS CONTROL METHOD FOR BUILDING DEMOLITION

    Science.gov (United States)

    This presentation describes the preliminary results of the evaluations of the alternative asbestos control method for demolishing buildings containing asbestos, and are covered under the regulatory requirements of the Asbestos NESHAP. This abstract and presentation are based, at ...

  11. Electron and high-dose-rate brachytherapy boost in the conservative treatment of stage I-II breast cancer. First results of the randomized Budapest boost trial

    Energy Technology Data Exchange (ETDEWEB)

    Polgar, C.; Fodor, J. [National Institute of Oncology, Department of Radiotherapy, Budapest (Hungary); Orosz, Z. [National Institute of Oncology, Center of Experimental and Human Tumor Pathology Budapest (HU)] [and others

    2002-11-01

    Background and Aims: To evaluate the effect of electron and high-dose-rate brachytherapy (HDR BT) boost on local tumor control (LTC), side effects and cosmesis after breast-conserving surgery (BCS) in a prospective randomized study. Patients and Methods: 207 women with stage I-II breast cancer who underwent BCS were treated by 50 Gy irradiation to the whole breast and then randomly assigned to receive either a boost to the tumor bed (n=104) or no further radiotherapy (n=103). Boost treatments consisted of either 16 Gy electron irradiation (n=52) or 12-14.25 Gy HDR BT (n=52). Breast cancer-related events, side effects, and cosmetic results were assessed. Results: At a median follow-up of 5.3 years, the crude rate of local recurrence was 6.7% (7/104) with and 15.5% (16/103) without boost. The 5-year probability of LTC, relapse-free survival (RFS), and cancer-specific survival (CSS) was 92.7% vs 84.9% (p=0.049), 76.6% vs 66.2% (p=0.044), and 90.4% vs. 82.1% (p=0.053), respectively. There was no significant difference in LTC between patients treated with electron or HDR BT boost (94.2% vs 91.4%; p=0.74). On multivariate analysis, patient age <40 years (RR: 4.53), positive margin status (RR: 4.17), and high mitotic activity index (RR: 3.60) were found to be significant risk factors for local recurrence. The incidence of grade 2-3 side effects was higher in the boost arm (17.3% vs 7.8%; p=0.03). However, the rate of excellent/good cosmetic results was similar for the two arms (85.6% vs 91.3%; p=0.14). Cosmesis was rated as excellent/good in 88.5% of patients treated with HDR BT and 82.7% of patients with electron boost (p=0.29). Conclusions: Boost dose significantly improves LTC and RFS in patients treated with BCS and radiotherapy. In spite of the higher incidence of late side effects in the boost arm, boost dose is strongly recommended for patients at high risk for local recurrence. Positive or close margin status, high mitotic activity index, and young patient age

  12. Weekly Cisplatin and Volumetric-Modulated Arc Therapy With Simultaneous Integrated Boost for Radical Treatment of Advanced Cervical Cancer in Elderly Patients: Feasibility and Clinical Preliminary Results.

    Science.gov (United States)

    Mazzola, Rosario; Ricchetti, Francesco; Fiorentino, Alba; Levra, Niccolò Giaj; Fersino, Sergio; Di Paola, Gioacchino; Ruggieri, Ruggero; Alongi, Filippo

    2017-06-01

    To evaluate the feasibility and clinical preliminary results of weekly cisplatin and volumetric-modulated arc therapy to the pelvis with simultaneous integrated boost to macroscopic disease in a cohort of elderly patients. Inclusion criteria of this prospective study were age ≥70 years, Karnofsky performance status 70 to 100, locally advanced histologically proven squamous cervical carcinoma, and patients unable to undergo brachytherapy. Radiation doses prescribed were 66 Gy to the macroscopic disease and 54 Gy to the pelvic nodes in 30 fractions. Weekly cisplatin dose was 40 mg/mq. A total of 30 patients were recruited. Median follow-up was 32 months (range: 8-48 months). Median age was 72 years (range: 70-84 years). The 3-year overall survival and local control were 93% and 80%, respectively. The median time to progression was 24 months (range: 6-30 months). Analyzing clinical outcome grouping based on the stage of disease, II versus III, the 3-year overall survival was 100% and 85%, respectively. The 3-year local control was 91% for stage II and 67% for stage III. Acute and late toxicities were acceptable without severe events. Weekly cisplatin and volumetric-modulated arc therapy-simultaneous integrated boost for radical treatment of advanced cervical cancer in the current cohort of elderly patients were feasible. Long-term results and prospective randomized trials are advocated.

  13. Long-Term Results of an RTOG Phase II Trial (00-19) of External-Beam Radiation Therapy Combined With Permanent Source Brachytherapy for Intermediate-Risk Clinically Localized Adenocarcinoma of the Prostate

    Energy Technology Data Exchange (ETDEWEB)

    Lawton, Colleen A., E-mail: clawton@mcw.edu [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States); Yan, Yan [Radiation Therapy Oncology Group Statistical Center, Philadelphia, PA (United States); Lee, W. Robert [Department of Radiation Oncology, Duke University School of Medicine, Durham, NC (United States); Gillin, Michael [Department of Radiation Oncology, MD Anderson Cancer Center, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Firat, Selim [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States); Baikadi, Madhava [Department of Radiation Oncology, Northeast Radiation Oncology Center, Scranton, PA (United States); Crook, Juanita [Department of Radiation Oncology, University of British Columbia, Kelowna, BC (Canada); Kuettel, Michael [Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, NY (United States); Morton, Gerald [Department of Radiation Oncology, Toronto-Sunnybrook Regional Cancer Center, Toronto, ON (Canada); Sandler, Howard [Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA (United States)

    2012-04-01

    Purpose: External-beam radiation therapy combined with low-doserate permanent brachytherapy are commonly used to treat men with localized prostate cancer. This Phase II trial was performed to document late gastrointestinal or genitourinary toxicity as well as biochemical control for this treatment in a multi-institutional cooperative group setting. This report defines the long-term results of this trial. Methods and Materials: All eligible patients received external-beam radiation (45 Gy in 25 fractions) followed 2-6 weeks later by a permanent iodine 125 implant of 108 Gy. Late toxicity was defined by the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer late radiation morbidity scoring scheme. Biochemical control was defined by the American Society for Therapeutic Radiology and Oncology (ASTRO) Consensus definition and the ASTRO Phoenix definition. Results: One hundred thirty-eight patients were enrolled from 20 institutions, and 131 were eligible. Median follow-up (living patients) was 8.2 years (range, 2.7-9.3 years). The 8-year estimate of late grade >3 genitourinary and/or gastrointestinal toxicity was 15%. The most common grade >3 toxicities were urinary frequency, dysuria, and proctitis. There were two grade 4 toxicities, both bladder necrosis, and no grade 5 toxicities. In addition, 42% of patients complained of grade 3 impotence (no erections) at 8 years. The 8-year estimate of biochemical failure was 18% and 21% by the Phoenix and ASTRO consensus definitions, respectively. Conclusion: Biochemical control for this treatment seems durable with 8 years of follow-up and is similar to high-dose external beam radiation alone or brachytherapy alone. Late toxicity in this multi-institutional trial is higher than reports from similar cohorts of patients treated with high-dose external-beam radiation alone or permanent low-doserate brachytherapy alone, perhaps suggesting further attention to strategies that limit doses to

  14. External-Beam Radiation Therapy and High-Dose Rate Brachytherapy Combined With Long-Term Androgen Deprivation Therapy in High and Very High Prostate Cancer: Preliminary Data on Clinical Outcome

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-Monge, Rafael, E-mail: rmartinezm@unav.es [Department of Radiation Oncology, Clinica Universitaria de Navarra, University of Navarra, Pamplona, Navarre (Spain); Moreno, Marta; Ciervide, Raquel; Cambeiro, Mauricio [Department of Radiation Oncology, Clinica Universitaria de Navarra, University of Navarra, Pamplona, Navarre (Spain); Perez-Gracia, Jose Luis; Gil-Bazo, Ignacio [Department of Medical Oncology, Clinica Universitaria de Navarra, University of Navarra, Pamplona, Navarre (Spain); Gaztanaga, Miren; Arbea, Leire [Department of Radiation Oncology, Clinica Universitaria de Navarra, University of Navarra, Pamplona, Navarre (Spain); Pascual, Ignacio [Department of Urology, Clinica Universitaria de Navarra, University of Navarra, Pamplona, Navarre (Spain); Aristu, Javier [Department of Radiation Oncology, Clinica Universitaria de Navarra, University of Navarra, Pamplona, Navarre (Spain)

    2012-03-01

    Purpose: To determine the feasibility of combined long-term androgen deprivation therapy (ADT) and dose escalation with high-dose-rate (HDR) brachytherapy. Methods and Materials: Between 2001 and 2007, 200 patients with high-risk prostate cancer (32.5%) or very high-risk prostate cancer (67.5%) were prospectively enrolled in this Phase II trial. Tumor characteristics included a median pretreatment prostate-specific antigen of 15.2 ng/mL, a clinical stage of T2c, and a Gleason score of 7. Treatment consisted of 54 Gy of external irradiation (three-dimensional conformal radiotherapy [3DCRT]) followed by 19 Gy of HDR brachytherapy in four twice-daily treatments. ADT started 0-3 months before 3DCRT and continued for 2 years. Results: One hundred and ninety patients (95%) received 2 years of ADT. After a median follow-up of 3.7 years (range, 2-9), late Grade {>=}2 urinary toxicity was observed in 18% of the patients and Grade {>=}3 was observed in 5%. Prior transurethral resection of the prostate (p = 0.013) and bladder D{sub 50} {>=}1.19 Gy (p = 0.014) were associated with increased Grade {>=}2 urinary complications; age {>=}70 (p = 0.05) was associated with Grade {>=}3 urinary complications. Late Grade {>=}2 gastrointestinal toxicity was observed in 9% of the patients and Grade {>=}3 in 1.5%. CTV size {>=}35.8 cc (p = 0.007) and D{sub 100} {>=}3.05 Gy (p = 0.01) were significant for increased Grade {>=}2 complications. The 5-year and 9-year biochemical relapse-free survival (nadir + 2) rates were 85.1% and 75.7%, respectively. Patients with Gleason score of 7-10 had a decreased biochemical relapse-free survival (p = 0.007). Conclusions: Intermediate-term results at the 5-year time point indicate a favorable outcome without an increase in the rate of late complications.

  15. External Beam Radiation Therapy or Brachytherapy With or Without Short-course Neoadjuvant Androgen Deprivation Therapy: Results of a Multicenter, Prospective Study of Quality of Life

    Energy Technology Data Exchange (ETDEWEB)

    Gay, Hiram A., E-mail: hiramgay@wustl.edu [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri (United States); Sanda, Martin G. [Department of Urology, Emory University School of Medicine, Atlanta, Georgia (United States); Liu, Jingxia; Wu, Ningying [Division of Public Health Sciences, Washington University School of Medicine, St. Louis, Missouri (United States); Hamstra, Daniel A. [Texas Center for Proton Therapy, Irving, Texas (United States); Wei, John T.; Dunn, Rodney L. [Department of Urology, University of Michigan, Ann Arbor, Michigan (United States); Klein, Eric A. [Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio (United States); Sandler, Howard M. [Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, California (United States); Saigal, Christopher S. [Department of Urology, University of California at Los Angeles, Los Angeles, California (United States); Litwin, Mark S. [Department of Urology, University of California at Los Angeles, Los Angeles, California (United States); Health Policy and Management, University of California at Los Angeles, Los Angeles, California (United States); Kuban, Deborah A. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Hembroff, Larry [Institute for Public Policy and Social Research, Michigan State University, East Lansing, Michigan (United States); Regan, Meredith M. [Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts (United States); Chang, Peter [Department of Surgery, Beth Israel-Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts (United States); Michalski, Jeff M. [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri (United States); Regan, Meredith; Hembroff, Larry; Wei, John T.; Hamstra, Dan; and others

    2017-06-01

    Purpose: The long-term effects of neoadjuvant androgen deprivation therapy (NADT) with radiation therapy on participant-reported health-related quality of life (HRQOL) have not been characterized in prospective multicenter studies. We evaluated HRQOL for 2 years among participants undergoing radiation therapy (RT) with or without NADT for newly diagnosed, early-stage prostate cancer. Methods and Materials: We analyzed longitudinal cohort data from the Prostate Cancer Outcomes and Satisfaction with Treatment Quality Assessment Consortium to ascertain the HRQOL trajectory of men receiving NADT with external beam RT (EBRT) or brachytherapy. HRQOL was measured using the expanded prostate cancer index composite 26-item questionnaire at 2, 6, 12, and 24 months after the initiation of NADT. We used the χ{sup 2} or Fisher exact test to compare the shift in percentages between groups that did or did not receive NADT. Analyses were conducted at the 2-sided 5% significance level. Results: For subjects receiving EBRT, questions regarding the ability to have an erection, ability to reach an orgasm, quality of erections, frequency of erections, ability to function sexually, and lack of energy were in a significantly worse dichotomized category for the patients receiving NADT. Comparing the baseline versus 24-month outcomes, 24%, 23%, and 30% of participants receiving EBRT plus NADT shifted to the worse dichotomized category for the ability to reach an orgasm, quality of erections, and ability to function sexually compared with 14%, 13%, and 16% in the EBRT group, respectively. Conclusions: Compared with baseline, at 2 years, participants receiving NADT plus EBRT compared with EBRT alone had worse HRQOL, as measured by the ability to reach orgasm, quality of erections, and ability to function sexually. However, no difference was found in the ability to have an erection, frequency of erections, overall sexual function, hot flashes, breast tenderness/enlargement, depression

  16. Description and preliminary results of the PACEM 2 experimental program

    Science.gov (United States)

    Gole, P.; Lavergnat, J.; Sylvain, M.

    The CNET experimental PACEM program, which is aimed at obtaining a better understanding of multipath propagation on microwave line-of-sight channels, is considered. The results of a previous experiment on channel modeling is summarized, and an experiment investigating the seasonal variations on a space diversity channel is described. To monitor the experiment remotely, an efficient data compression technique that involved Hadamard transforming was used. It is shown that the number of significant transform coefficients allows a quick evaluation of the propagation channel behavior without decompressing the data. First results obtained using the method are presented for a one-year period.

  17. Preliminary results from an infrared hyperspectral imaging polarimeter

    Science.gov (United States)

    Craven-Jones, Julia; Kudenov, Michael W.; Stapelbroek, Maryn G.; Dereniak, Eustace L.

    2011-10-01

    We present results from a SWIR/MWIR infrared hyperspectral imaging polarimeter (IHIP). The sensor includes a pair of sapphire Wollaston prisms and several high order retarders to form an imaging Fourier transform spectropolarimeter. The Wollaston prisms serve as a birefringent interferometer with reduced sensitivity to vibration versus an unequal path interferometer, such as a Michelson. Polarimetric data are acquired through the use of channeled spectropolarimetry to modulate the spectrum with the Stokes parameter information. We discuss the operation of the IHIP sensor, in addition to our calibration techniques. Lastly, spectropolarimetric results from the laboratory and outdoor tests are presented.

  18. Family Characteristics of Anxious ADHD Children: Preliminary Results

    Science.gov (United States)

    Kepley, Hayden O.; Ostrander, Rick

    2007-01-01

    Objective: To investigate the family environments of children in a community sample with ADHD and co-occurring anxiety. Method: Family Environment Scale, Behavioral Assessment System for Children, and Structured Clinical Interview are administered to parents of children with ADHD with and without anxiety. Results: ADHD families are uniformly less…

  19. Multiaxial fatigue of aluminium friction stir welded joints: preliminary results

    Directory of Open Access Journals (Sweden)

    D. G. Hattingh

    2015-07-01

    Full Text Available The aim of the present research is to check the accuracy of the Modified Wöhler Curve Method (MWCM in estimating the fatigue strength of friction stir (FS welded tubular joints of Al 6082-T6 subjected to in-phase and out-of-phase multiaxial fatigue loading. The welded samples being investigated were manufactured by equipping an MTS I-STIR process development system with a retracting tool that was specifically designed and optimised for this purpose. These specimens were tested under proportional and non-proportional tension and torsion, the effect of non-zero mean stresses being also investigated. The validation exercise carried out by using the generated experimental results allowed us to prove that the MWCM (applied in terms of nominal stresses is highly accurate in predicting the fatigue strength of the tested FS welded joints, its usage resulting in estimates falling with the uniaxial and torsional calibration scatter bands.

  20. Preliminary results of in vitro propagation of Guayule

    Science.gov (United States)

    Dastoor, M. N.; Schubert, W. W.; Petersen, G. R.

    1981-01-01

    Guayule, Parthenium argentatum Gray, was first established in tissue culture by Bonner and Arreguin (1950) as a means to study the effects of various chemicals and extracts on rubber production. The propagation of whole guayule plants from tissue culture, however, has not been accomplished. The reported investigation is concerned with such an objective. In an attempt to stimulate rubber production in Guayule, Yokoyama et al. (1977) sprayed juvenile plants with 2-(3,4-dichloro-phenoxy)triethylamine (TEA derivative). This treatment resulted in increased isoprenoid levels in the plant tissue. In the current investigation, experiments were conducted to study the effect of TEA derivative on in vitro cultures. It was found that a suppression of callus formation occurs at a 10 mg/L concentration of TEA derivative with a resultant increase of shoot formation. Lower and higher concentrations of TEA derivative promote callus formation.

  1. Are saponins and sapogenins precursors of prednisolone? Preliminary results

    Directory of Open Access Journals (Sweden)

    Giuseppe Federico Labella

    2015-11-01

    Full Text Available The transformation of cortisol into prednisolone in cattle faeces was demonstrated and provided by literature, given the structural similarity of prednisolone with cortisol. In this study, we evaluated a possible neo-formation of prednisolone, as results of a faecal or environmental contamination. A saponine, α-solanine, and a sapogenin, diosgenin, were selected as possible precursors. A simple method without extraction was applied. The analyses were performed by HPLC–MSn to evaluate the possible transformations. The results showed that prednisolone was detected in the faecal suspension spiked with diosgenin at t= 8h, while cortisol was also detected at t = 24h in the sample of faeces spiked with α-solanine. In the feed and in the control samples, no transformations were observed.

  2. Preliminary results on the stability of switched positive linear systems

    Energy Technology Data Exchange (ETDEWEB)

    Gurvits, L. (Leonid)

    2004-01-01

    It was recently conjectured that the Hurwitz stability of a polytope of Metzler matrices is a necessary and sufficient condition for the stability of the associated switched linear system for arbitrary switching sequences. In this paper we show: (i) that this conjecture is true for a polytope constructed from a pair of second order Metzler matrices; (ii) that the conjecture is true for general polytopes of a finite number of second order Metzler matrices; and (iii) that the conjecture is in general false for higher order systems. The implications of our results, both for the design of switched positive linear systems, and for research directions that arise as a result of our work, are discussed toward the end of the paper.

  3. OPM3® Portugal project : analysis of preliminary results

    OpenAIRE

    Silva, David; Tereso, Anabela; Fernandes, Gabriela; Pinto, José Ângelo

    2014-01-01

    Project Management (PM) has emerged as a crucial factor that determines the success of an organization. In this sense, there is a growing concern for organizations to assess their PM maturity. This paper presents the PM maturity results for 19 organizations, using Organizational Project Management Maturity Model (OPM3®) emerging from OPM3® Portugal Project research, that is presently in progress. All aspects of OPM3® Portugal Project are explained in detail, and a brief descriptiv...

  4. Impediments to Marketing African Natural products From Ghana: Preliminary Results

    OpenAIRE

    Govindasamy, Ramu; Onyango, Benjamin M.; Puduri, Venkata S.; Simon, James E.; Asante-Dartey, Juliana; Arthur, Hanson; Diawuo, Bismarck; Acquaye, Dan

    2006-01-01

    For most of the African countries agriculture still remains the mainstay of the economies supplying both food and incomes via marketable surpluses. However, many odds against agriculture such low productivity, poor prices, and drought among others make it unsustainable. Results thus far show that such dependence has contributed little to neither economic development nor growth. Still many of its people living on and from agriculture remain poor, and are susceptible to hunger and malnutrition....

  5. Preliminary operational results of the industrial process heat field tests

    Energy Technology Data Exchange (ETDEWEB)

    Kutscher, C.; Davenport, R.

    1980-04-01

    There are currently six DOE-funded solar industrial process heat (IPH) field tests which have been operational for one year or longer. These are all low temperature first generation projects which supply heat at temperatures below 100/sup 0/C - three hot water and three hot air. During the 1979 calendar year, personnel from the Solar Energy Research Institute (SERI) visited all of these sites; the performance and cost results obtained for each project and the operational problems encountered at each site are discussed.

  6. Fourier shape descriptors in fish preliminary results with Prochilodus

    Science.gov (United States)

    Torres, Audalio Rebelo; Silva, Josielma dos Santos; Neta, Raimunda Nonata Fortes Carvalho

    2017-11-01

    In this work, we analyzed fifteen Prochilodus applying Fourier shape descriptors techniques in order to test a method potential to detect and distinguish features like gonadal stage. The technique consists in obtains captured images from the fishes with high resolution, digitized the contours of the fish and obtains Cartesian coordinates of the points in the fish image border. These coordinates of each fish is adjusted to a Fourier discrete polynomial and the variability of each harmonic is obtained and evaluated. The initial results show a promising potential in distinguish fish features.

  7. Ramadan fasting: Evidence or expert opinion? Results of preliminary studies

    Directory of Open Access Journals (Sweden)

    Maryam Kazemi

    2013-12-01

    Full Text Available Each year, over a billion Muslims fast worldwide during the month of Ramadan.  Through this religious practice, not only will one have spiritual growth, but can improve his/her diet, which is of pivotal importance in this month. Conversely, the available evidence regarding the health benefits of Ramadan fasting is scarce and highly contentious. Although Islam exempts patients from fasting, many of them fast conceivably and their clinical condition is prone to deteriorate. This is due to the persistent gap between current expert knowledge and conclusive, strong evidence regarding the pathophysiologic and metabolic alterations by fasting, and the consensus that healthcare professionals should reach, in order to manage various patient groups during this month. In this review, we summarize the results of our initial studies regarding the effects of Ramadan fasting on some clinical conditions including alterations of body composition. We also go through the important clinical results of patients who have had previous history of cardiovascular disease, type 2 diabetes, asthma and renal colic. Our studies have presented some evidence in favor of Ramadan fasting and encourage those with mentioned diseases to consult their physicians and follow medical and scientific recommendations. We attempt to present some relevant evidence clarify future scopes in this area of study, and provide suggestions for future investigations.

  8. Robot-assisted radical prostatectomy in Brazil: preliminary results

    Directory of Open Access Journals (Sweden)

    Jose Roberto Colombo Junior

    2009-12-01

    Full Text Available Purpose: To report the initial experience on robot-assisted radical prostatectomy in Brazil. Methods: From March 2008 to March 2009, a hundred patients were treated with robot-assisted radical prostatectomy. Patient’s demographic data, as well as perioperative results of the procedures, are described in this study. Rresults: Patients’ mean age and mean PSA were 58 years and 7.58 ng/ml, respectively. All procedures were performed through transperitoneal approach, with a mean bleeding of 480 mL and surgical time of 298 minutes. A surgical margin affected by cancer was present in 16% of the cases. There were four complications: bleeding requiring transfusion (two cases, rectal perforation corrected on the spot and inadequate functioning of the robot. There was no conversion to another access or obit occurrences in this caseload. Cconclusions: Robot-assisted prostatectomy is a reality in Brazil and the results herein presented demonstrate that this procedure can be safely performed. Long-term follow-up is still necessary to assess the oncological and functional outcomes.

  9. Preliminary Results From a Newly Established Behavioral Health Home

    Directory of Open Access Journals (Sweden)

    Alexandros Maragakis

    2015-05-01

    Full Text Available Objective: Individuals with serious mental illness (SMI have higher rates of preventable diseases such as diabetes in comparison to the general population. While multifaceted, these high rates of preventable diseases in the population with SMI may be partially attributed to limited access to primary care. A new program, the Behavioral Health Home (BHH, which allows for the delivery of somatic care coordination and population-based care, may provide this population with the much needed somatic coordination and education it requires. Methods: The impact of the population-based health management program of the BHH identification and severity rating of glucose metabolism disorders was assessed during the initial 10 months of the BHH. Results: Multiple patients were identified who either were not having hemoglobin A1c (HbA1c levels drawn per recommended guidelines for individuals prescribed antipsychotic medications or were within diabetic range but did not have a diagnosis of diabetes. Mixed results occurred in regard to patients’ HbA1c levels while engaging in the BHH. Conclusion: This case study provides some initial evidence for the utility of the BHH in regard to identifying patients who need preventive care.

  10. Ramadan fasting: Evidence or expert opinion? Results of preliminary studies

    Directory of Open Access Journals (Sweden)

    1Maryam Kazemi

    2013-11-01

    Full Text Available Each year, over a billion Muslims fast worldwide during the month of Ramadan. Through this religious practice, not only will one have spiritual growth, but can improve his/her diet, which is of pivotal importance in this month. Conversely, the available evidence regarding the health benefits of Ramadan fasting is scarce and highly contentious. Although Islam exempts patients from fasting, many of them fast conceivably and their clinical condition is prone to deteriorate. This is due to the persistent gap between current expert knowledge and conclusive, strong evidence regarding the pathophysiologic and metabolic alterations by fasting, and the consensus that healthcare professionals should reach, in order to manage various patient groups during this month. In this review, we summarize the results of our initial studies regarding the effects of Ramadan fasting on some clinical conditions including alterations of body composition. We also go through the important clinical results of patients who have had previous history of cardiovascular disease, type 2 diabetes, asthma and renal colic. Our studies have presented some evidence in favor of Ramadan fasting and encourage those with mentioned diseases to consult their physicians and follow medical and scientific recommendations. We attempt to present some relevant evidence clarify future scopes in this area of study, and provide suggestions for future investigations.

  11. Involution of categorical thinking processes in Alzheimer's disease: Preliminary results

    Directory of Open Access Journals (Sweden)

    Claudia Berlim de Mello

    Full Text Available Abstract Alzheimer's disease (AD is a degenerative brain disorder characterized by progressive losses in cognitive functions, including memory. The sequence of these losses may correspond to the inverse order of the normal sequence of ontogenetic cognitive acquisitions, a process named retrogenesis. One of the acquisitions that improve in normal development is the ability to retrieve previously acquired categorical knowledge from semantic memory in order to guide associative thinking and memory processes; consequently, children become able to associate verbal stimuli in more complex taxonomic ways and to use this knowledge to improve their recall. Objective: In this study, we investigated if AD-related deterioration of semantic memory involves a decrease in categorical thinking processes with progression of the disease, according to the retrogenesis hypothesis. Methods: We compared the performance of AD patients at mild and moderate stages, and of groups of 7, 10 and 14-year-old children in tasks of free association along with recall tasks of perceptually and semantically related stimuli. Results: ANOVAS showed a decrease in taxonomic associations and an increase in diffuse associations between mild and moderate stages, corresponding to the inverse order shown by the child groups. At the moderate AD stage, the pattern was similar to that of 7-year-old children. Both groups of patients performed worse than child groups in recall tasks. Conclusions: These results corroborate the hypothesis of an involution of the processes of categorical associative thinking in the course of the disease.

  12. Preliminary Hydrogeologic Characterization Results from the Wallula Basalt Pilot Study

    Energy Technology Data Exchange (ETDEWEB)

    B.P. McGrail; E. C. Sullivan; F. A. Spane; D. H. Bacon; G. Hund; P. D. Thorne; C. J. Thompson; S. P. Reidel; F. S. Colwell

    2009-12-01

    The DOE's Big Sky Regional Carbon Sequestration Partnership has completed drilling the first continental flood basalt sequestration pilot borehole to a total depth (TD) of 4,110 feet on the Boise White Paper Mill property at Wallula, Washington. Site suitability was assessed prior to drilling by the 2007-2008 acquisition, processing and analysis of a four-mile, five-line three component seismic swath, which was processed as a single data-dense line. Analysis of the seismic survey data indicated a composite basalt formation thickness of {approx}8,000 feet and absence of major geologic structures (i.e., faults) along the line imaged by the seismic swath. Drilling of Wallula pilot borehole was initiated on January 13, 2009 and reached TD on April 6, 2009. Based on characterization results obtained during drilling, three basalt breccia zones were identified between the depth interval of 2,716 and 2,910 feet, as being suitable injection reservoir for a subsequent CO2 injection pilot study. The targeted injection reservoir lies stratigraphically below the massive Umtanum Member of the Grande Ronde Basalt, whose flow-interior section possesses regionally recognized low-permeability characteristics. The identified composite injection zone reservoir provides a unique and attractive opportunity to scientifically study the reservoir behavior of three inter-connected reservoir intervals below primary and secondary caprock confining zones. Drill cuttings, wireline geophysical logs, and 31one-inch diameter rotary sidewall cores provided geologic data for characterization of rock properties. XRF analyses of selected rock samples provided geochemical characterizations of the rocks and stratigraphic control for the basalt flows encountered by the Wallula pilot borehole. Based on the geochemical results, the pilot borehole was terminated in the Wapshilla Ridge 1 flow of the Grande Ronde Basalt Formation. Detailed hydrologic test characterizations of 12 basalt interflow

  13. Preliminary results on Macroalgae distribution in destructive processes

    Directory of Open Access Journals (Sweden)

    O.I. OSKOLSKAYA

    2001-06-01

    Full Text Available It has been shown, that the destruction of the coastal strip in region of action of Mikhailovsky landslide results in change of species structure and dominant species photophilous Cystoseira barbara on sciophylous Gracilaria verrucosa. In accordance with increasing sediments amount in sea water biomass and the morpho-functional parameters of the photophilous species are reducing, and at the sciophylous are growing. Progressing phenomenon of epiphytism is observed in algal populations in the southern part of researched region which is possible to consider as response reaction, leads to increase a synthesizing surface. Decreasing physiological activity is compensated by growth of the total surface of macrophytes. The increase of a sea water sediments leads to lowering ratio of long and shortwave pigments level of ATP-ase activity and raising concentration of the total sum of pigments in thalli.

  14. Paradoxical sleep characteristics and cultural environment. Preliminary results.

    Science.gov (United States)

    Petre-Quadens, O; Hussain, H; Balaratnan, C

    1975-01-01

    The Temiars are a tribe of negroid pygmies of basically Proto-Malaysian affinities. Field-work in the Malaysian jungle provided some observations on the sleep-wakefulness cycle of two young Temiar adults. This cycle was monophasic circumstances permitting. Their rest-activity cycle at night was similar in the jungle and in the laboratory. Polygraphic total night-sleep recordings were made with both of them in the EEG laboratory in the Hospital Besar in Kuala Lumpur. The eye-movement frequencies of PS were compared with those from young adults of the West. Although the differences were not statistically significant, the Rem-densities of the Temiars were constantly at the low side. The significance of the results are being discussed.

  15. Modeling intrinsic electrophysiology of AII amacrine cells: preliminary results.

    Science.gov (United States)

    Apollo, Nick; Grayden, David B; Burkitt, Anthony N; Meffin, Hamish; Kameneva, Tatiana

    2013-01-01

    In patients who have lost their photoreceptors due to retinal degenerative diseases, it is possible to restore rudimentary vision by electrically stimulating surviving neurons. AII amacrine cells, which reside in the inner plexiform layer, split the signal from rod bipolar cells into ON and OFF cone pathways. As a result, it is of interest to develop a computational model to aid in the understanding of how these cells respond to the electrical stimulation delivered by a prosthetic implant. The aim of this work is to develop and constrain parameters in a single-compartment model of an AII amacrine cell using data from whole-cell patch clamp recordings. This model will be used to explore responses of AII amacrine cells to electrical stimulation. Single-compartment Hodgkin-Huxley-type neural models are simulated in the NEURON environment. Simulations showed successful reproduction of the potassium currentvoltage relationship and some of the spiking properties observed in vitro.

  16. Preliminary results on bubble detector as personal neutron dosemeter.

    Science.gov (United States)

    Ponraju, D; Krishnan, H; Viswanathan, S; Indira, R

    2011-03-01

    The bubble detector is demonstrated as one of the best suitable neutron detectors for neutron dose rate measurements in the presence of high-intense gamma fields. Immobilisation of a volatile liquid in a superheated state and achieving uniform distribution of tiny superheated droplets were a practical challenge. A compact and reusable bubble detector with high neutron sensitivity has been developed at the Indira Gandhi Centre for Atomic Research by immobilising the superheated droplets in a suitable polymer matrix. Two types of bubble detectors have been successfully developed, one by incorporating isobutane for measuring fast neutron and another by incorporating Freon-12 for both fast and thermal neutron. The performance of the detector has been tested using 5 Ci Am-Be neutron source and the results are described.

  17. Bioelectrical impedance analysis for bovine milk: Preliminary results

    Science.gov (United States)

    Bertemes-Filho, P.; Valicheski, R.; Pereira, R. M.; Paterno, A. S.

    2010-04-01

    This work reports the investigation and analysis of bovine milk quality by using biological impedance measurements using electrical impedance spectroscopy (EIS). The samples were distinguished by a first chemical analysis using Fourier transform midinfrared spectroscopy (FTIR) and flow citometry. A set of milk samples (100ml each) obtained from 17 different cows in lactation with and without mastitis were analyzed with the proposed technique using EIS. The samples were adulterated by adding distilled water and hydrogen peroxide in a controlled manner. FTIR spectroscopy and flow cytometry were performed, and impedance measurements were made in a frequency range from 500Hz up to 1MHz with an implemented EIS system. The system's phase shift was compensated by measuring saline solutions. It was possible to show that the results obtained with the Bioelectrical Impedance Analysis (BIA) technique may detect changes in the milk caused by mastitis and the presence of water and hydrogen peroxide in the bovine milk.

  18. Preliminary results from the ASF/GPS ice classification algorithm

    Science.gov (United States)

    Cunningham, G.; Kwok, R.; Holt, B.

    1992-01-01

    The European Space Agency Remote Sensing Satellite (ERS-1) satellite carried a C-band synthetic aperture radar (SAR) to study the earth's polar regions. The radar returns from sea ice can be used to infer properties of ice, including ice type. An algorithm has been developed for the Alaska SAR facility (ASF)/Geophysical Processor System (GPS) to infer ice type from the SAR observations over sea ice and open water. The algorithm utilizes look-up tables containing expected backscatter values from various ice types. An analysis has been made of two overlapping strips with 14 SAR images. The backscatter values of specific ice regions were sampled to study the backscatter characteristics of the ice in time and space. Results show both stability of the backscatter values in time and a good separation of multiyear and first-year ice signals, verifying the approach used in the classification algorithm.

  19. Preliminary results on scintigraphic evaluation of malignant external otitis

    Energy Technology Data Exchange (ETDEWEB)

    Malamitsi, J.; Maragoudakis, P. (Hippocrateion Hospital, Athens (Greece). Dept. of Nuclear Medicine); Papafragou, K.; Koukouliou, V. (Athens Univ. (Greece). Dept. of Medical Physics); Kalatzis, Y.; Adamopoulos, G.; Proukakis, C. (Hippocrateion Hospital, Athens (Greece). ORL Univ. Clinic)

    1993-06-01

    Malignant external otitis (MEO) is a potentially fatal otitis occurring in diabetic and immunosuppressed patients, which may cause cranial nerve palsies and massive thrombophlebitis of the brain. We studied five diabetic patients with the clinical diagnosis of external otitis who were suspected of having MEO and one diabetic patient presumed cured from MEO. All of them underwent methylene diphosphonate, nanocolloid and gallium single-photon emission tomography studies with quantitative analysis on the basis of regions of interest and count profile curves. This combined assessment helped us to diagnose and follow-up soft tissue and temporal bone infection, especially in the case of transsphenoidal extension of the disease, since conventional radiology and computed tomography were of no particular help. On the basis of these results, we consider scintigraphic demonstration of skull base infection as a fourth criterion of MEO given that the classical Chandler's triad (diabetes, granuloma, and Pseudomonas aeruginosa) is not always present. (orig.).

  20. Performance and Preliminary Results From FIREBALL and CWI.

    Science.gov (United States)

    Matuszewski, Mateusz; Martin, D.

    2011-01-01

    The Faint Intergalactic Redshifted Emission Balloon (FIREBALL) is a balloon-borne, vaccuum ultraviolet (200 nm), fiber-fed integral field spectrograph designed to observe line emission from the intergalactic (IGM) and circumgalactic (CGM) media in the redshift range 0.3 1.0. It had its first successful science flight in Juny 2009. The Cosmic Web Imager (CWI) is a slicer-based integral field spectrograph built for the 200" Hale Telescope at Palomar Observatory. It is designed to detect and map line emission from the IGM, CGM and circum-QSO medium (CQM) in the redshift range 2 < z < 7. The design, construction, commissioning, and initial scientific results of FIREBALL and CWI are presented.

  1. Methane in permafrost - Preliminary results from coring at Fairbanks, Alaska

    Science.gov (United States)

    Kvenvolden, K.A.; Lorenson, T.D.

    1993-01-01

    Permafrost has been suggested as a high-latitude source of methane (a greenhouse gas) during global warming. To begin to assess the magnitude of this source, we have examined the methane content of permafrost in samples from shallow cores (maximum depth, 9.5m) at three sites in Fairbanks, Alaska, where discontinuous permafrost is common. These cores sampled frozen loess, peat, and water (ice) below the active layer. Methane contents of permafrost range from permafrost worldwide over the next 100 years, given two climate change scenarios. Our results indicate that at least 30 years will elapse before melting permafrost releases important amounts of methane; a maximum methane release rate will be about 25 to 30 Tg/yr, assuming that methane is generally distributed in shallow permafrost as observed in our samples.

  2. NEOWISE OBSERVATIONS OF NEAR-EARTH OBJECTS: PRELIMINARY RESULTS

    Energy Technology Data Exchange (ETDEWEB)

    Mainzer, A.; Bauer, J.; Masiero, J.; Eisenhardt, P. [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Grav, T.; Mo, W. [Department of Physics and Astronomy, Johns Hopkins University, Baltimore, MD (United States); McMillan, R. S. [Lunar and Planetary Laboratory, University of Arizona, 1629 East University Blvd., Tucson, AZ 85721-0092 (United States); Cutri, R. M. [Infrared Processing and Analysis Center, California Institute of Technology, Pasadena, CA 91125 (United States); Walker, R. [Monterey Institute for Research in Astronomy, Monterey, CA (United States); Wright, E. [Department of Physics and Astronomy, UCLA, P.O. Box 91547, Los Angeles, CA 90095-1547 (United States); Tholen, D. J.; Jedicke, R.; Denneau, L. [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI (United States); Spahr, T. [Minor Planet Center, Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); DeBaun, E. [Department of Physics and Astronomy, Dartmouth University, Hanover, NH 03755 (United States); Elsbury, D. [University of California Santa Barbara, Broida Hall, Santa Barbara, CA 93103 (United States); Gautier, T. [Cornell University, Ithaca, NY 14853 (United States); Gomillion, S. [Department of Engineering Physics, Embry-Riddle Aeronautical University, 600 S. Clyde Morris Boulevard, Daytona Beach, FL 32114 (United States); Hand, E. [Department of Mechanical Engineering, University of Missouri-Kansas City, Kansas City, MO 64110 (United States); Watkins, J., E-mail: amainzer@jpl.nasa.gov [Department of Earth and Space Sciences, UCLA, 595 Charles Young Drive East, Box 951567, Los Angeles, CA 90095 (United States); and others

    2011-12-20

    With the NEOWISE portion of the Wide-field Infrared Survey Explorer (WISE) project, we have carried out a highly uniform survey of the near-Earth object (NEO) population at thermal infrared wavelengths ranging from 3 to 22 {mu}m, allowing us to refine estimates of their numbers, sizes, and albedos. The NEOWISE survey detected NEOs the same way whether they were previously known or not, subject to the availability of ground-based follow-up observations, resulting in the discovery of more than 130 new NEOs. The survey's uniform sensitivity, observing cadence, and image quality have permitted extrapolation of the 428 near-Earth asteroids (NEAs) detected by NEOWISE during the fully cryogenic portion of the WISE mission to the larger population. We find that there are 981 {+-} 19 NEAs larger than 1 km and 20,500 {+-} 3000 NEAs larger than 100 m. We show that the Spaceguard goal of detecting 90% of all 1 km NEAs has been met, and that the cumulative size distribution is best represented by a broken power law with a slope of 1.32 {+-} 0.14 below 1.5 km. This power-law slope produces {approx}13, 200 {+-} 1900 NEAs with D > 140 m. Although previous studies predict another break in the cumulative size distribution below D {approx} 50-100 m, resulting in an increase in the number of NEOs in this size range and smaller, we did not detect enough objects to comment on this increase. The overall number for the NEA population between 100 and 1000 m is lower than previous estimates. The numbers of near-Earth comets and potentially hazardous NEOs will be the subject of future work.

  3. TURBulence Ocean Lidar (TURBOL): preliminary results of laboratory experiments

    Science.gov (United States)

    Josset, D. B.; Hou, W.; Goode, W.; Nootz, G.; Matt, S.

    2016-02-01

    Turbulence is a critical property of the ocean mixed layer and has a direct impact on ocean heat storage and algae photosynthesis. Observing changes in turbulence at the synoptic scale is quite challenging. Research vessels provide a limited geographic/temporal coverage and most systems used to characterize turbulence use in situ instrumentations which disturb the flow and affects turbulence itself. Lidar observations are a promising way to study the ocean properties. Polarization is one of the three key properties of light, in addition to intensity and color (frequency). Each of these properties provides different information about the medium the light passes through, however the information provided by polarization is unique in characterizing the properties of the media. Underwater polarization can be used to study the optical signature of inorganic particles in coastal waters from remote sensing and recent research has shown that scattering due to optical turbulence can be expressed as a function of the depolarization rate. The TURBulence Ocean Lidar is an experimental system, aimed at characterizing underwater turbulence by examining various Stokes parameters. In this presentation, we propose to discuss several results from the laboratory setup of the lidar system, including how the polarization signature is affected by the turbulence intensity. Although the effect on the degree of polarization appears to be a monotonic function of turbulence intensity, our results suggest that the way the light intensity shifts between the different Stokes parameter is much more complex. While this is not unexpected from a theoretical point of view, this has different implications on the optimal configurations of ocean lidar system based on polarization.

  4. Fragility fractures of the pelvis: treatment and preliminary results.

    Science.gov (United States)

    Arduini, M; Saturnino, L; Piperno, A; Iundusi, R; Tarantino, U

    2015-10-01

    With increasing life expectancy, fragility fractures of the pelvic ring (FFP) are becoming frequent. In elderly, osteoporosis leads to a decrease of bone strength and resistance to the ligament's traction; this represents the most important difference between FFP and fractures in young patients. Usually, these fractures are underestimated and treatment is often conservative. To evaluate clinical and surgical outcomes of surgically treated patients with FFP. We retrospectively enrolled 14 patients, in our Trauma Center, underwent surgery procedures for FFP between 2012 and 2014. All patients attended clinical and radiological investigation at 1, 3, and 6 months postoperatively and every year after surgery with a mean follow-up of 22 months. At 6-month follow-up, 11 patients resulted asymptomatic: able to maintain standing position and walk without crunches. Two patients were able to walk with one crunch. The patient with history of previous acetabular fracture walks with two crunches and is still waiting for total hip arthroplasty. The compromised health status and the diminished bone-healing capacity, in elderly, decrease chances for a good clinical outcome. In literature, many authors suggest that mortality rate in patients with FFP is similar to those with hip fracture. Diagnosis of FFP is very important: these fractures are highly disabling in elderly and can lead to displacement and instability. For these reasons, correct diagnosis and well-conduct preoperative plan are necessary to improve stability of fractures and support bone healing. After diagnosis, an anti-osteoporotic treatment is indicated to improve bone quality and bone healing. Our study shows encouraging results and demonstrates that minimally or less invasive osteosynthesis technique could lead to good outcome in these patients.

  5. [Arrest of spermatogenesis by various antibiotics: preliminary experimental results].

    Science.gov (United States)

    Dokov, V K; Timmermans, L

    1970-07-01

    9 antibiotics used in urology were injected for 8 days into male rats, and their effects observed on testicular histochemistry and histology. The antibiotics were: spiramycin 25 mg/kg, N-(5-nitro-furfurylidene)-1-amino 2 mg/kg, gentamycin sulfate 1.2 mg/kg, sodium chloramphenicol succinate 30 mg/kg, colimycin methane sulfonate 20,000 U/kg, framycetin sulfate 10 mg/kg, 7-(thiophene-2-acetamido-cephalosporanate sodium 30 mg/kg, crystalline potassium penicillin G 40,000 U/kg and oxytetracycline 10 mg/kg (injection routes not specified). The results were classified into 3 categories: first, gentamycin nitrofurfurlidine-aminohydantoine and oxytetracycline arrested cell division in spermatogonia and partially or totally blocked meiosis in primary spermatocytes. The Feulgen reaction (a stain for DNA) was faint in the germinal epithelium. In the second category were spiramycin, thiophene-acetamido-cephalosporanate, colimycin and framycetin, which inhibited mitosis in spermatogonia, therefore permitting few primary spermatocytes to reach metaphase. In the third group were penicillin G and chloramphenicol which partly or completely blocked mitotsis in spermatogonia. In all cases interstitial capillaries were congested. The severity of effect was least with penic illin, moderate with oxytetracycline, and generalized and severe with the others. Histochemical stains showed strong activity of glucose-6-phosphate and isocitric dehydrogenase in the interstitial cells, and in the spermatogonia, but lower than normal in the spermatids and spermatozoa. Glutamate dehydrogenase was low in spermatogonia and primary spermatocytes. Classification of these antibiotics according to these results did not resemble any known chemical or antibacterial class ification.

  6. Sodium and potassium lidar system and preliminary result in Brazil

    Science.gov (United States)

    Du, Lifang

    2017-04-01

    This paper reported that the first sodium and potassium lidar was built at November, 2016 in INPE(S23°,W45°) by National Space Science Center, Chinese Academy of Sciences. This system first time realized the potassium and sodium metal layer at the same time above the detection In South America. The lidar system use a powerful pulse YAG laser to pumped two dye lasers at the same time, and join the advanced technology, such as narrow line-width grating technique, efficient laser frequency doubling technique, wavelength automatic locking technique and the double optical fiber in the focal plane for spectra separation technique and so on, which made the 589 nm and 770 nm laser line width to achieve 0.03cm-1 and the laser frequency doubling efficiency to reached above 65%. In this way, the simultaneously detecting the atmosphere at the altitude of 80 110 km by sodium and potassium fluorescence in one lidar facility has been realized. On November 20, 2016, this system began to observation for the first time in Brazil, and it has the detection data of South America about potassium and sodium at the same time. Observed data show that sodium echo photon counting rate is higher than 31874count/160s/96m, potassium echo photon counting rate is higher than 2153count/320s/96m. Comparing with both of at home or abroad, the results are a very good. In particular, the detection results level of potassium take the leading position in the international.

  7. Auditory discrimination therapy (ADT) for tinnitus managment: preliminary results.

    Science.gov (United States)

    Herraiz, C; Diges, I; Cobo, P; Plaza, G; Aparicio, J M

    2006-12-01

    This clinical assay has demonstrated the efficacy of auditory discrimination therapy (ADT) in tinnitus management compared with a waiting-list group. In all, 43% of the ADT patients improved their tinnitus, and its intensity together with its handicap were statistically decreased (EMB rating: B-2). To describe the effect of sound discrimination training on tinnitus. ADT designs a procedure to increase the cortical representation of trained frequencies (damaged cochlear areas with a secondary reduction of cortical stimulation) and to shrink the neighbouring over-represented ones (corresponding to tinnitus pitch). This prospective descriptive study included 14 patients with high frequency matched tinnitus. Tinnitus severity was measured according to a visual analogue scale (VAS) and the Tinnitus Handicap Inventory (THI). Patients performed a 10-min auditory discrimination task twice a day for 1 month. Discontinuous 8 kHz pure tones were randomly mixed with 500 ms 'white noise' sounds through a MP3 system. ADT group results were compared with a waiting-list group (n=21). In all, 43% of our patients had improvement in their tinnitus. A significant improvement in VAS (p=0.004) and THI mean scores was achieved (p=0.038). Statistical differences between ADT and the waiting-list group have been proved, considering patients' self-evaluations (p=0.043) and VAS scores (p=0.004). A non-significant reduction of THI was achieved (p=0.113).

  8. Combined optical and single photon emission imaging: preliminary results.

    Science.gov (United States)

    Boschi, Federico; Spinelli, Antonello E; D'Ambrosio, Daniela; Calderan, Laura; Marengo, Mario; Sbarbati, Andrea

    2009-12-07

    In vivo optical imaging instruments are generally devoted to the acquisition of light coming from fluorescence or bioluminescence processes. Recently, an instrument was conceived with radioisotopic detection capabilities (Kodak in Vivo Multispectral System F) based on the conversion of x-rays from the phosphorus screen. The goal of this work is to demonstrate that an optical imager (IVIS 200, Xenogen Corp., Alameda, USA), designed for in vivo acquisitions of small animals in bioluminescent and fluorescent modalities, can even be employed to detect signals due to radioactive tracers. Our system is based on scintillator crystals for the conversion of high-energy rays and a collimator. No hardware modifications are required. Crystals alone permit the acquisition of photons coming from an in vivo 20 g nude mouse injected with a solution of methyl diphosphonate technetium 99 metastable (Tc99m-MDP). With scintillator crystals and collimators, a set of measurements aimed to fully characterize the system resolution was carried out. More precisely, system point spread function and modulation transfer function were measured at different source depths. Results show that system resolution is always better than 1.3 mm when the source depth is less than 10 mm. The resolution of the images obtained with radioactive tracers is comparable with the resolution achievable with dedicated techniques. Moreover, it is possible to detect both optical and nuclear tracers or bi-modal tracers with only one instrument.

  9. Size dependent differences in litter consumption of isopods: preliminary results

    Directory of Open Access Journals (Sweden)

    Ferenc Vilisics

    2012-03-01

    Full Text Available A series of experiments were applied to test how leaf orientation within microcosms affect consumption rates (Experiment 1, and to discover intra-specific differences in leaf litter consumption (Experiment 2 of the common isopod species Porcellio scaber and Porcellionides pruinosus. A standardised microcosm setup was developed for feeding experiments to maintain standard conditions. A constant amount of freshly fallen black poplar litter was provided to three distinct size class (small, medium, large of woodlice. We measured litter consumption after a fortnight. We maintained appr. constant isopod biomass for all treatments, and equal densities within each size class. We hypothesized that different size classes differ in their litter consumption, therefore such differences should occur even within populations of the species. We also hypothesized a marked difference in consumption rates for different leaf orientation within microcosms. Our results showed size-specific consumption patterns for P. scaber: small adults showed the highest consumption rates (i.e. litter mass loss / isopod biomass in high density microcosms, while medium-sized adults of lower densities ate the most litter in containers. Leaf orientation posed no significant effect on litter consumption.

  10. Preliminary results from the heavy ions in space experiment

    Science.gov (United States)

    Adams, James H., Jr.; Beahm, Lorraine P.; Tylka, Allan J.

    1992-01-01

    The Heavy Ions In Space (HIIS) experiment has two primary objectives: (1) to measure the elemental composition of ultraheavy galactic cosmic rays, beginning in the tin-barium region of the periodic table; and (2) to study heavy ions which arrive at LDEF below the geomagnetic cutoff, either because they are not fully stripped of electrons or because their source is within the magnetosphere. Both of these objectives have practical as well as astrophysical consequences. In particular, the high atomic number of the ultraheavy galactic cosmic rays puts them among the most intensely ionizing particles in Nature. They are therefore capable of upsetting electronic components normally considered immune to such effects. The below cutoff heavy ions are intensely ionizing because of their low velocity. They can be a significant source of microelectronic anomalies in low inclination orbits, where Earth's magnetic field protects satellites from most particles from interplanetary space. The HIIS results will lead to significantly improved estimates of the intensely ionizing radiation environment.

  11. Combined optical and single photon emission imaging: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Boschi, Federico; Calderan, Laura; Sbarbati, Andrea [Department of Morphological-Biomedical Sciences, Section of Anatomy and Histology, University of Verona, Verona (Italy); Spinelli, Antonello E [Medical Physics Department, San Raffaele Scientific Institute, Milan (Italy); D' Ambrosio, Daniela; Marengo, Mario [Medical Physics Department, S. Orsola Malpighi Hospital, Bologna (Italy)], E-mail: federico.boschi@univr.it

    2009-12-07

    In vivo optical imaging instruments are generally devoted to the acquisition of light coming from fluorescence or bioluminescence processes. Recently, an instrument was conceived with radioisotopic detection capabilities (Kodak in Vivo Multispectral System F) based on the conversion of x-rays from the phosphorus screen. The goal of this work is to demonstrate that an optical imager (IVIS 200, Xenogen Corp., Alameda, USA), designed for in vivo acquisitions of small animals in bioluminescent and fluorescent modalities, can even be employed to detect signals due to radioactive tracers. Our system is based on scintillator crystals for the conversion of high-energy rays and a collimator. No hardware modifications are required. Crystals alone permit the acquisition of photons coming from an in vivo 20 g nude mouse injected with a solution of methyl diphosphonate technetium 99 metastable (Tc99m-MDP). With scintillator crystals and collimators, a set of measurements aimed to fully characterize the system resolution was carried out. More precisely, system point spread function and modulation transfer function were measured at different source depths. Results show that system resolution is always better than 1.3 mm when the source depth is less than 10 mm. The resolution of the images obtained with radioactive tracers is comparable with the resolution achievable with dedicated techniques. Moreover, it is possible to detect both optical and nuclear tracers or bi-modal tracers with only one instrument. (letter to the editor)

  12. Beijing Lightning Network (BLNET): Configuration, Function and Preliminary Results

    Science.gov (United States)

    Qie, X.; Wang, D.; Wang, Y.; Liu, M.; Tian, Y.; Lu, G.

    2015-12-01

    A regional multi-frequency-band lightning detection network in Beijing (BLNET) has been developed for both research and operational purposes. The network is employed in the experiment of Dynamic-microphysical-electrical Processes in Severe Thunderstorms and Lightning Hazards (Storm973), supported by Ministry of Science and Technology as National Key Basic Research Program of China or 973 Program. The network consisted of 16 stations in 2015 covering most part of The "Jing-Jin-Ji" (Beijing-Tianjin-Hebei) metropolis zone, one of the most developed areas in China. Four different sensors, including slow antenna, fast antenna, magnetic antenna, and VHF antenna, are integrated in each station to detect lightning radiation signals in different frequency band. The Chan algorithm and Levenberg-Marquardt method are adopted jointly in the lightning location algorithm. In addition to locate the lightning radiation pulses in two-dimension or three-dimension in different band, the charge source neutralized by the lightning discharge can be retrieved either. The theoretical horizontal error over the network is less than 200 m and the vertical error is less than 500 m over the network. The comparison of total lightning location results with corresponding radar echoes for thunderstorm cases indicates the good performance of BLNET in the severe convection surveillance. The actual two-dimensional location error in VLF/LF band, compared with a ground truth that acquired with a GPS-synchronized high-speed video camera, is about 250 m.

  13. Flight Test 4 Preliminary Results: NASA Ames SSI

    Science.gov (United States)

    Isaacson, Doug; Gong, Chester; Reardon, Scott; Santiago, Confesor

    2016-01-01

    Realization of the expected proliferation of Unmanned Aircraft System (UAS) operations in the National Airspace System (NAS) depends on the development and validation of performance standards for UAS Detect and Avoid (DAA) Systems. The RTCA Special Committee 228 is charged with leading the development of draft Minimum Operational Performance Standards (MOPS) for UAS DAA Systems. NASA, as a participating member of RTCA SC-228 is committed to supporting the development and validation of draft requirements as well as the safety substantiation and end-to-end assessment of DAA system performance. The Unmanned Aircraft System (UAS) Integration into the National Airspace System (NAS) Project conducted flight test program, referred to as Flight Test 4, at Armstrong Flight Research Center from April -June 2016. Part of the test flights were dedicated to the NASA Ames-developed Detect and Avoid (DAA) System referred to as JADEM (Java Architecture for DAA Extensibility and Modeling). The encounter scenarios, which involved NASA's Ikhana UAS and a manned intruder aircraft, were designed to collect data on DAA system performance in real-world conditions and uncertainties with four different surveillance sensor systems. Flight test 4 has four objectives: (1) validate DAA requirements in stressing cases that drive MOPS requirements, including: high-speed cooperative intruder, low-speed non-cooperative intruder, high vertical closure rate encounter, and Mode CS-only intruder (i.e. without ADS-B), (2) validate TCASDAA alerting and guidance interoperability concept in the presence of realistic sensor, tracking and navigational errors and in multiple-intruder encounters against both cooperative and non-cooperative intruders, (3) validate Well Clear Recovery guidance in the presence of realistic sensor, tracking and navigational errors, and (4) validate DAA alerting and guidance requirements in the presence of realistic sensor, tracking and navigational errors. The results will be

  14. The gated electrostatic mass spectrometer (GEMS): definition and preliminary results.

    Science.gov (United States)

    Herrero, Federico A; Jones, Hollis H; Lee, Jeffrey G

    2008-10-01

    GEMS is a new type of time-of-flight mass spectrometer based on an electrostatic energy analyzer. Mass resolution equals the energy analyzer kinetic energy resolution, which is set by its slit size. In GEMS, monochromatic ions enter the entrance slit at random times, and the gated ion deflection produced by the electrostatic field in the analyzer rejects ions that are inside the analyzer at gate onset, detecting those entering the analyzer after gate onset. This provides mass separation while overcoming the temporal and spatial spread problems typical of TOF applications. Paradoxically, GEMS works because all ion masses follow identical trajectories. GEMS is easily multiplied into two-dimensional arrays to increase sensitivity in space applications, requires relatively low voltages, and uses only a few electrical connections. Thus, it is easy to package GEMS as a small, low-power instrument for applications in harsh environments. A disadvantage of GEMS is that its output is the integral of the TOF spectrum and the derivative of the raw data must be taken, a procedure that is likely to add noise. A version of GEMS detecting un-deflected ions (u-GEMS) has been tested to demonstrate the time-integrated feature of the raw data but without the benefit of energy analysis. This paper describes GEMS implemented with the small deflection energy analyzer (SDEA), a compact version of the parallel plate energy analyzer. SDEA is described both analytically and with ion trajectory simulations using the ion trajectory simulation software SIMION; the results are then used to describe GEMS and compute its performance.

  15. The HCV Synthesis Project: Scope, methodology, and preliminary results

    Directory of Open Access Journals (Sweden)

    Scheinmann Roberta

    2008-09-01

    Full Text Available Abstract Background The hepatitis C virus (HCV is hyper-endemic in injecting drug users. There is also excess HCV among non-injection drug users who smoke, snort, or sniff heroin, cocaine, crack, or methamphetamine. Methods To summarize the research literature on HCV in drug users and identify gaps in knowledge, we conducted a synthesis of the relevant research carried out between 1989 and 2006. Using rigorous search methods, we identified and extracted data from published and unpublished reports of HCV among drug users. We designed a quality assurance system to ensure accuracy and consistency in all phases of the project. We also created a set of items to assess study design quality in each of the reports we included. Results We identified 629 reports containing HCV prevalence rates, incidence rates and/or genotype distribution among injecting or non-injecting drug user populations published between January 1989 and December 2006. The majority of reports were from Western Europe (41%, North America (26%, Asia (11% and Australia/New Zealand (10%. We also identified reports from Eastern Europe, South America, the Middle East, and the Caribbean. The number of publications reporting HCV rates in drug users increased dramatically between 1989 and 2006 to 27–52 reports per year after 1998. Conclusion The data collection and quality assurance phases of the HCV Synthesis Project have been completed. Recommendations for future research on HCV in drug users have come out of our data collection phase. Future research reports can enhance their contributions to our understanding of HCV etiology by clearly defining their drug user participants with respect to type of drug and route of administration. Further, the use of standard reporting methods for risk factors would enable data to be combined across a larger set of studies; this is especially important for HCV seroconversion studies which suffer from small sample sizes and low power to examine risk

  16. Antiresorptive Treatment for Spaceflight Induced Bone Atrophy - Preliminary Results

    Science.gov (United States)

    LeBlanc, Adrian; Matsumoto, toshio; Jones, Jeff; Shapiro, Jay; Lang, Thomas; Shackelford, Linda C.; Smith, Scott M.; Evans, Harlan J.; Spector, Elisabeth R.; Ploutz-Snyder, Robert; hide

    2011-01-01

    Detailed measurements from the Mir and ISS long duration missions have documented losses in bone mineral density (BMD) from critical skeletal sub-regions. The most important BMD losses are from the femoral hip, averaging about -1.6%/mo integral to -2.3%/mo trabecular. Importantly these studies have documented the wide range in individual BMD loss from -0.5 to -5%/mo. Associated elevated urinary Ca increases the risk of renal stone formation during flight, a serious impact to mission success. To date, countermeasures have not been satisfactory. The purpose of this study is to determine if the combined effect of anti-resorptive drugs plus the standard in-flight exercise regimen will have a measurable effect on preventing space flight induced bone loss (mass and strength) and reducing renal stone risk. To date, 4 crewmembers have completed the flight portion of the protocol in which crewmembers take a 70-mg alendronate tablet once a week before and during flight, starting 17 days before launch. Compared to previous ISS crewmembers (n=14) not taking alendronate, DXA measurements of the spine, femur neck and total hip were significantly improved from -0.8 +/- 0.5%/mo to 1.0 +/- 1.1%/mo, -1.1 +/- 0.5%/mo to -0.2 +/- 0.3%/mo, -1.1 +/- 0.5%/mo to 0.04 +/- 0.3%/mo respectively. QCT-determined trabecular BMD of the femur neck, trochanter and total hip were significantly improved from -2.7 +/- 1.9%/mo to -0.2 +/- 0.8%/mo, -2.2 +/- 0.9%/mo to -0.3 +/- 1.9%/mo and -2.3 +/- 1.0%/mo to -0.2 +/- 1.8%/mo respectively. Significance was calculated from a one-tailed t test. Resorption markers were unchanged, in contrast to measurements from previous ISS crewmembers that showed typical increases of 50-100% above baseline. Urinary Ca showed no increase compared to baseline levels, also distinct from the elevated levels of 50% or greater in previous crews. While these results are encouraging, the current n (4) is small, and the large SDs indicate that, while the means are improved, there

  17. Dating of polyhalite and langbeinite: preliminary results from German Zechstein

    Science.gov (United States)

    Neubauer, Franz; Schorn, Anja; Leitner, Christoph; Genser, Johann

    2013-04-01

    formation temperatures are given between 57.1 ° C or more commonly 83 ° C (e.g. Neitzel, 1992 and references therein), is mined as potash ore at the German Zechstein deposits. Neitzel (1992) summarized two main types of langbeinite formation (1) from kainite and halite (due to thermal metamorphism) and (2) from sylvinitic Hartsalz (= mixture of sylvite, kieserite and halite) due to solution metamorphism. The mineral might also form by decomposition of polyhalite to langbeinite and anhydrite during prograde metamorphism. In the following, we discuss the first successful results of polyhalite and langbeinite dating in Zechstein salts of Germany (Morsleben, Neuhof). Extremely fine-grained (grain sizes International Journal of Earth Sciences, DOI 10.1007/s00531-012-0836-6. Neitzel, U., 1992. 100 Jahre Langbeinit. Kali und Steinsalz, 11/1, 7-13. Renne, P. R., Sharp, W. D. Montañez, I. P., Becker, R. A., Zierenberg, R. A., 2001. 40Ar/39Ar dating of Late Permian evaporites, southeastern New Mexico, USA. Earth and Planetary Science Letters, 193, 539-547. Warren, J. K., 2006. Evaporite

  18. Modern head and neck brachytherapy: from radium towards intensity modulated interventional brachytherapy

    Science.gov (United States)

    2014-01-01

    Intensity modulated brachytherapy (IMBT) is a modern development of classical interventional radiation therapy (brachytherapy), which allows the application of a high radiation dose sparing severe adverse events, thereby further improving the treatment outcome. Classical indications in head and neck (H&N) cancers are the face, the oral cavity, the naso- and oropharynx, the paranasal sinuses including base of skull, incomplete resections on important structures, and palliation. The application type can be curative, adjuvant or perioperative, as a boost to external beam radiation as well as without external beam radiation and with palliative intention. Due to the frequently used perioperative application method (intraoperative implantation of inactive applicators and postoperative performance of radiation), close interdisciplinary cooperation between surgical specialists (ENT-, dento-maxillary-facial-, neuro- and orbital surgeons), as well interventional radiotherapy (brachytherapy) experts are obligatory. Published results encourage the integration of IMBT into H&N therapy, thereby improving the prognosis and quality of life of patients. PMID:25834586

  19. Hypofractionated image guided radiation therapy followed by prostate seed implant boost for men with newly diagnosed intermediate and high risk adenocarcinoma of the prostate: Preliminary results of a phase 2 prospective study

    Directory of Open Access Journals (Sweden)

    Steven Gresswell, MD

    2016-10-01

    Conclusions: Early results on the toxicity and efficacy of the combination of hypofractionated IG-IMRT and low-dose-rate brachytherapy boost are favorable. Longer follow-up is needed to confirm safety and effectiveness.

  20. Electronic brachytherapy management of atypical fibroxanthoma: report of 8 lesions

    OpenAIRE

    Stephen Doggett; James Brazil; Marketa Limova; Leah Press; Sidney Smith; Jeremy Peck

    2017-01-01

    Purpose : To evaluate the suitability of treating atypical fibroxanthoma (AFX), an uncommon skin malignancy, with electronic brachytherapy. Material and methods : From Feb 2013 to Sep 2014, we were referred a total of 8 cases of AFX in 7 patients, all involving the scalp. All of them were treated with electronic brachytherapy 50 Kev radiations (Xoft Axxent®, Fremont, California). All lesions received 40 Gy in two fractions per week with 5mm margins. Results : At a median follow-up...

  1. Prostate brachytherapy in Ghana: our initial experience

    Directory of Open Access Journals (Sweden)

    James Edward Mensah

    2016-10-01

    Full Text Available Purpose: This study presents the experience of a brachytherapy team in Ghana with a focus on technology transfer and outcome. The team was initially proctored by experienced physicians from Europe and South Africa. Material and methods : A total of 90 consecutive patients underwent either brachytherapy alone or brachytherapy in combination with external beam radiotherapy for prostate carcinoma between July 2008 and February 2014 at Korle Bu Teaching Hospital, Accra, Ghana. Patients were classified as low-risk, intermediate, and high-risk according to the National Comprehensive Cancer Network (NCCN criteria. All low-risk and some intermediate risk group patients were treated with seed implantation alone. Some intermediate and all high-risk group patients received brachytherapy combined with external beam radiotherapy. Results: The median patient age was 64.0 years (range 46-78 years. The median follow-up was 58 months (range 18-74 months. Twelve patients experienced biochemical failure including one patient who had evidence of metastatic disease and died of prostate cancer. Freedom from biochemical failure rates for low, intermediate, and high-risk cases were 95.4%, 90.9%, and 70.8%, respectively. Clinical parameters predictive of biochemical outcome included: clinical stage, Gleason score, and risk group. Pre-treatment prostate specific antigen (PSA was not a statistically significant predictor of biochemical failure. Sixty-nine patients (76.6% experienced grade 1 urinary symptoms in the form of frequency, urgency, and poor stream. These symptoms were mostly self-limiting. Four patients needed catheterization for urinary retention (grade 2. One patient developed a recto urethral fistula (grade 3 following banding for hemorrhoids. Conclusions : Our results compare favorably with those reported by other institutions with more extensive experience. We believe therefore that, interstitial permanent brachytherapy can be safely and effectively

  2. Hybrid microneedles devices for diagnostic and therapeutic applications: fabrication and preliminary results

    Science.gov (United States)

    Dardano, P.; Caliò, A.; Politi, J.; Di Palma, V.; Bevilacqua, M. F.; Rea, I.; Casalino, M.; Di Matteo, A.; Rendina, I.; De Stefano, L.

    2015-06-01

    Microneedles are newly developed biomedical devices, whose advantages are mainly in the non-invasiveness, discretion and versatility of use both as diagnostics and as therapeutics tool. In fact, they can be used both for drugs delivery in the interstitial fluids and for the analysis of the interstitial fluid. In this work we present the preliminary results for two devices based on micro needles in PolyEthylene (Glycol). The first for the drugs delivery includes a membrane whose optical reflected wavelength is related to the concentration of drug. Here, we present our preliminary result in diffusion of drugs between the membrane and the microneedles. The second device is gold coated and it works as electrode for the electrochemical detection of species in the interstitial fluid. A preliminary result in detection of glucose will be shown.

  3. Prostate brachytherapy in Ghana: our initial experience.

    Science.gov (United States)

    Mensah, James Edward; Yarney, Joel; Vanderpuye, Verna; Akpakli, Evans; Tagoe, Samuel; Sasu, Evans

    2016-10-01

    This study presents the experience of a brachytherapy team in Ghana with a focus on technology transfer and outcome. The team was initially proctored by experienced physicians from Europe and South Africa. A total of 90 consecutive patients underwent either brachytherapy alone or brachytherapy in combination with external beam radiotherapy for prostate carcinoma between July 2008 and February 2014 at Korle Bu Teaching Hospital, Accra, Ghana. Patients were classified as low-risk, intermediate, and high-risk according to the National Comprehensive Cancer Network (NCCN) criteria. All low-risk and some intermediate risk group patients were treated with seed implantation alone. Some intermediate and all high-risk group patients received brachytherapy combined with external beam radiotherapy. The median patient age was 64.0 years (range 46-78 years). The median follow-up was 58 months (range 18-74 months). Twelve patients experienced biochemical failure including one patient who had evidence of metastatic disease and died of prostate cancer. Freedom from biochemical failure rates for low, intermediate, and high-risk cases were 95.4%, 90.9%, and 70.8%, respectively. Clinical parameters predictive of biochemical outcome included: clinical stage, Gleason score, and risk group. Pre-treatment prostate specific antigen (PSA) was not a statistically significant predictor of biochemical failure. Sixty-nine patients (76.6%) experienced grade 1 urinary symptoms in the form of frequency, urgency, and poor stream. These symptoms were mostly self-limiting. Four patients needed catheterization for urinary retention (grade 2). One patient developed a recto urethral fistula (grade 3) following banding for hemorrhoids. Our results compare favorably with those reported by other institutions with more extensive experience. We believe therefore that, interstitial permanent brachytherapy can be safely and effectively performed in a resource challenged environment if adequate training

  4. Dosimetric characteristics of a new unit for electronic skin brachytherapy.

    Science.gov (United States)

    Garcia-Martinez, Teresa; Chan, Jan-Pieter; Perez-Calatayud, Jose; Ballester, Facundo

    2014-03-01

    Brachytherapy with radioactive high dose rate (HDR) (192)Ir source is applied to small skin cancer lesions, using surface applicators, i.e. Leipzig or Valencia type. New developments in the field of radiotherapy for skin cancer include electronic brachytherapy. This technique involves the placement of an HDR X-ray source close to the skin, therefore combining the benefits of brachytherapy with the reduced shielding requirements and targeted energy of low energy X-rays. Recently, the Esteya(®) Electronic Brachytherapy System (Esteya EBS, Elekta AB-Nucletron, Stockholm, Sweden) has been developed specifically for HDR brachytherapy treatment of surface lesions. The system provides radionuclide free HDR brachytherapy by means of a small 69.5 kV X-ray source. The purpose of this study is to obtain the dosimetric characterization required for clinical implementation, providing the detailed methodology to perform the commissioning. Flatness, symmetry and penumbra, percentage of depth dose (PDD), kV stability, HVL, output, spectrum, linearity, and leakage have been evaluated for a set of applicators (from 10 mm to 30 mm in diameter). Flatness and symmetry resulted better than 5% with around 1 mm of penumbra. The depth dose gradient is about 7%/mm. A kV value of 68.4 ± 1.0 kV (k = 1) was obtained, in good agreement with manufacturer data (69.5 kV). HVL was 1.85 mm Al. Dose rate for a typical 6 Gy to 7 Gy prescription resulted about 3.3 Gy/min and the leakage value was Brachytherapy System presents excellent flatness and penumbra as with the Valencia applicator case, combined with an improved PDD, allowing treatment of lesions of up to a depth of 5 mm in combination with reduced treatment duration. The Esteya unit allows HDR brachytherapy superficial treatment within a minimally shielded environment due its low energy.

  5. The effect of parental involvement in CBT of anxious children: Preliminary results from a RCT study

    DEFF Research Database (Denmark)

    Esbjørn, Barbara Hoff; Breinholst, Sonja; Reinholdt-Dunne, Marie Louise

    2011-01-01

    Esbjørn, B. H., Breinholst, S., Reinholdt-Dunne, M. L., & Leth, I. (2011). The effect of parental involvement in CBT of anxious children: Preliminary results from a RCT study. Poster accepted for the Association for Behavioral and Cognitive Therapies, Toronto, Canada.......Esbjørn, B. H., Breinholst, S., Reinholdt-Dunne, M. L., & Leth, I. (2011). The effect of parental involvement in CBT of anxious children: Preliminary results from a RCT study. Poster accepted for the Association for Behavioral and Cognitive Therapies, Toronto, Canada....

  6. 75 FR 44229 - Certain Frozen Warmwater Shrimp from India: Preliminary Results of Antidumping Duty Changed...

    Science.gov (United States)

    2010-07-28

    ... of this order includes certain frozen warmwater shrimp and prawns, whether wild-caught (ocean... Sensitive Plastic Tape from Italy: Preliminary Results of Antidumping Duty Changed Circumstances Review, 75 FR 8925 (Feb. 26, 2010), unchanged in Pressure Sensitive Plastic Tape From Italy: Final Results of...

  7. Preliminary results of femtosecond laser-assisted descemet stripping endothelial keratoplasty

    NARCIS (Netherlands)

    Cheng, Yanny Y. Y.; Hendrikse, Fred; Pels, Elisabeth; Wijdh, Robert-Jan; van Cleynenbreugel, Hugo; Eggink, Cathariena A.; van Rij, Gabriel; Rijneveld, Wilhelmina J.; Nuijts, Rudy M. M. A.

    2008-01-01

    Objective: To evaluate the preliminary visual results of femtosecond laser-assisted descemet stripping endothelial keratoplasty (FS-DSEK). keratoplasty (FS-DSEK). Methods: We prospectively analyzed results of 20 consecutive patients with Fuchs endothelial dystrophy or aphakic/pseudophakic bullous

  8. 77 FR 45582 - Certain Pasta From Italy: Preliminary Results of the 15th (2010) Countervailing Duty...

    Science.gov (United States)

    2012-08-01

    ... (``IDM'') at 13. For the preliminary results in the instant administrative review, we provided the GOI... accompanying IDM at Comment 6. Although it was given multiple opportunities, the GOI's responses left us...- recurring,'' and allocated the benefits over time. See Pasta 14 Final Results and accompanying IDM at 17...

  9. 75 FR 18794 - Certain Orange Juice From Brazil: Preliminary Results of Antidumping Duty Administrative Review...

    Science.gov (United States)

    2010-04-13

    .... Comercio, Industria, and Agricultura (Fischer) and Sucocitrico Cutrale, S.A. (Cutrale). In Cutrale's.... Comercio, Industria, e Agricultura for the Preliminary Results in the 08-09 Antidumping Duty Administrative... Results--Fischer S.A. Comercio, Industria and Agricultura.'' 2. Test of Comparison Market Sales Prices On...

  10. Preliminary Results from Second Phase Sea Testing of the Wave Dragon Prototype Wave Energy Converter

    DEFF Research Database (Denmark)

    Soerensen, Hans Chr.; Tedd, James; Friis-Madsen, Erik

    2006-01-01

    In March 2006 the prototype Wave Dragon has been redeployed to a more energetic site in Nissum Bredning an inland sea in Western Denmark. This has followed a period of renovation of many aspects of the device which have resulted in 20% higher energy output. This paper describes the preliminary...... results from this period of testing at the higher energy site....

  11. Advantages of high-dose rate (HDR) brachytherapy in treatment of prostate cancer

    Science.gov (United States)

    Molokov, A. A.; Vanina, E. A.; Tseluyko, S. S.

    2017-09-01

    One of the modern methods of preserving organs radiation treatment is brachytherapy. This article analyzes the results of prostate brachytherapy. These studies of the advantages of high dose brachytherapy lead to the conclusion that this method of radiation treatment for prostate cancer has a favorable advantage in comparison with remote sensing methods, and is competitive, preserving organs in comparison to surgical methods of treatment. The use of the method of polyfocal transperineal biopsy during the brachytherapy session provides information on the volumetric spread of prostate cancer and adjust the dosimetry plan taking into account the obtained data.

  12. Parametrial boost using midline shielding results in an unpredictable dose to tumor and organs at risk in combined external beam radiotherapy and brachytherapy for locally advanced cervical cancer.

    Science.gov (United States)

    Fenkell, Louis; Assenholt, Marianne; Nielsen, Søren Kynde; Haie-Meder, Christine; Pötter, Richard; Lindegaard, Jacob; Tanderup, Kari

    2011-04-01

    Midline-blocked boost (MBB) fields are frequently used in the treatment of locally advanced cervical cancer. The purpose of this study was to evaluate the dose contribution from MBBs to tumor and organs at risk. Six patients with locally advanced cervical cancer (IIB-IIIB) treated with definitive chemoradiotherapy and magnetic resonance imaging (MRI)-guided brachytherapy were analyzed. A three-phase plan was modeled: 45 Gy (1.8 Gy per fraction) four-field box, 9 Gy (1.8 Gy per fraction) MBB (midline-shielded anteroposterior/posteroanterior fields), and intracavitary MRI-guided brachytherapy boost of 28 Gy (7 Gy per fraction). Midline shields 3, 4, and 5 cm wide were simulated for each patient. Brachytherapy and MBB plans were volumetrically summed. The rectum, sigmoid, and bladder minimum dose in the most exposed 2 cm(3) of an organ at risk (D(2 cc)) and high-risk clinical target volume (HR-CTV) and intermediate-risk clinical target volume (IR-CTV) D90 and D100 were evaluated. The intended HR-CTV D90 was 85 Gy or greater, and the intended IR-CTV D90 was greater than 60 Gy. After a 4-cm MBB, HR-CTV D90 remained lower than 85 Gy in all cases (mean, 74 Gy; range, 64-82 Gy). High-risk clinical target volume (85 Gy) coverage increased slightly from 73% (range, 64-82%) to 78% (range, 69-88%). Mean IR-CTV D90 increased from 56 Gy (range, 53-64 Gy) to 62 Gy (range, 59-67 Gy). Intermediate-risk clinical target volume 60-Gy dose coverage increased from 81% (range, 72-96%) to 96% (range, 90-100%). The mean volume irradiated to 85 Gy increased by 14 cm(3) (range, 10-22 cm(3)), whereas the volume irradiated to 60 Gy increased from 276 cm(3) (range, 185-417 cm(3)) to 592 cm(3) (range, 385-807 cm(3)). Bladder, rectum, or sigmoid D(2 cc) increased by more than 50% of the boost dose in 4 of 6 patients. Midline-blocked boosts contribute substantial dose to rectum, sigmoid, and bladder D(2 cc). HR-CTV dose and 85-Gy coverage remain compromised in large tumors despite MBB. IR-CTV 60

  13. Cognitive Task Analysis of Business Jet Pilots' Weather Flying Behaviors: Preliminary Results

    Science.gov (United States)

    Latorella, Kara; Pliske, Rebecca; Hutton, Robert; Chrenka, Jason

    2001-01-01

    This report presents preliminary findings from a cognitive task analysis (CTA) of business aviation piloting. Results describe challenging weather-related aviation decisions and the information and cues used to support these decisions. Further, these results demonstrate the role of expertise in business aviation decision-making in weather flying, and how weather information is acquired and assessed for reliability. The challenging weather scenarios and novice errors identified in the results provide the basis for experimental scenarios and dependent measures to be used in future flight simulation evaluations of candidate aviation weather information systems. Finally, we analyzed these preliminary results to recommend design and training interventions to improve business aviation decision-making with weather information. The primary objective of this report is to present these preliminary findings and to document the extended CTA methodology used to elicit and represent expert business aviator decision-making with weather information. These preliminary findings will be augmented with results from additional subjects using this methodology. A summary of the complete results, absent the detailed treatment of methodology provided in this report, will be documented in a separate publication.

  14. Image guided, adaptive, accelerated, high dose brachytherapy as model for advanced small volume radiotherapy.

    Science.gov (United States)

    Haie-Meder, Christine; Siebert, Frank-André; Pötter, Richard

    2011-09-01

    Brachytherapy has consistently provided a very conformal radiation therapy modality. Over the last two decades this has been associated with significant improvements in imaging for brachytherapy applications (prostate, gynecology), resulting in many positive advances in treatment planning, application techniques and clinical outcome. This is emphasized by the increased use of brachytherapy in Europe with gynecology as continuous basis and prostate and breast as more recently growing fields. Image guidance enables exact knowledge of the applicator together with improved visualization of tumor and target volumes as well as of organs at risk providing the basis for very individualized 3D and 4D treatment planning. In this commentary the most important recent developments in prostate, gynecological and breast brachytherapy are reviewed, with a focus on European recent and current research aiming at the definition of areas for important future research. Moreover the positive impact of GEC-ESTRO recommendations and the highlights of brachytherapy physics are discussed what altogether presents a full overview of modern image guided brachytherapy. An overview is finally provided on past and current international brachytherapy publications focusing on "Radiotherapy and Oncology". These data show tremendous increase in almost all research areas over the last three decades strongly influenced recently by translational research in regard to imaging and technology. In order to provide high level clinical evidence for future brachytherapy practice the strong need for comprehensive prospective clinical research addressing brachytherapy issues is high-lighted. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  15. Electronic brachytherapy management of atypical fibroxanthoma: report of 8 lesions

    Directory of Open Access Journals (Sweden)

    Stephen Doggett

    2017-01-01

    Full Text Available Purpose : To evaluate the suitability of treating atypical fibroxanthoma (AFX, an uncommon skin malignancy, with electronic brachytherapy. Material and methods : From Feb 2013 to Sep 2014, we were referred a total of 8 cases of AFX in 7 patients, all involving the scalp. All of them were treated with electronic brachytherapy 50 Kev radiations (Xoft Axxent®, Fremont, California. All lesions received 40 Gy in two fractions per week with 5mm margins. Results : At a median follow-up of 23.7 months, the local recurrence rate is 12.5%. The single lesion that failed was not debulked surgically prior to electronic brachytherapy. Conclusions : To our knowledge, this is the first report in the literature on the use of radiation therapy as curative primary treatment for AFX. No contraindication to the use of radiations is found in the literature, with surgery being the sole treatment for AFX noted. Our recurrence rate is 0% for debulked lesions. Risk of recurrence is mitigated with surgical debulking prior to brachytherapy. Electronic brachytherapy appears to be a safe and effective treatment for debulked AFX. Multiple excisions, skin grafting, and wound care can be avoided in elderly patients by the use of electronic brachytherapy.

  16. Trade-off results and preliminary designs of Near-Term Hybrid Vehicles

    Science.gov (United States)

    Sandberg, J. J.

    1980-01-01

    Phase I of the Near-Term Hybrid Vehicle Program involved the development of preliminary designs of electric/heat engine hybrid passenger vehicles. The preliminary designs were developed on the basis of mission analysis, performance specification, and design trade-off studies conducted independently by four contractors. THe resulting designs involve parallel hybrid (heat engine/electric) propulsion systems with significant variation in component selection, power train layout, and control strategy. Each of the four designs is projected by its developer as having the potential to substitute electrical energy for 40% to 70% of the petroleum fuel consumed annually by its conventional counterpart.

  17. 78 FR 66895 - Aluminum Extrusions From the People's Republic of China: Preliminary Results of Changed...

    Science.gov (United States)

    2013-11-07

    ... submitted on behalf of the Aluminum Extrusion Fair Trade Committee (AEFTC), the petitioners in the less-than... International Trade Administration Aluminum Extrusions From the People's Republic of China: Preliminary Results... Part AGENCY: Enforcement and Compliance, formerly Import Administration, International Trade...

  18. Preliminary results from the 'HXR' hard X-ray sky survey

    Energy Technology Data Exchange (ETDEWEB)

    Ubertini, P.; Bazzano, A.; LaPadula, C.; Polcaro, V.F.; Zambon, G. (Consiglio Nazionale delle Ricerche, Frascati (Italy). Lab. di Astrofisica Spaziale); Manchanda, R.K. (Tata Inst. of Fundamental Research, Bombay (India))

    1984-01-01

    The authors present the preliminary results of the HXR81M experiment: a one square meter hard X-ray balloon-borne telescope. The detected excesses on 14 sources are given in catalogue form and the spectra, reduced at the top of the atmosphere, of a number of galactic and extragalactic sources are shortly discussed.

  19. Lynx home range and movements in Montana and Wyoming: Preliminary results [Chapter 11

    Science.gov (United States)

    John R. Squires; Tom Laurion

    2000-01-01

    Preliminary telemetry data suggest that lynx in Montana and Wyoming have large home ranges; this result supports the Koehler and Aubry (1994) contention that lynx from southern lynx populations have large spatial-use areas. Annual home ranges of males were larger than females. Straight-line, daily travel distance averaged 2 to 4 km, which is similar to northern...

  20. Preliminary Results of Autotuning GEMM Kernels for the NVIDIA Kepler Architecture- GeForce GTX 680

    Energy Technology Data Exchange (ETDEWEB)

    Kurzak, Jakub [Univ. of Tennessee, Knoxville, TN (United States); Luszczek, Pitor [Univ. of Tennessee, Knoxville, TN (United States); Tomov, Stanimire [Univ. of Tennessee, Knoxville, TN (United States); Dongarra, Jack [Univ. of Tennessee, Knoxville, TN (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Manchester (United Kingdom)

    2012-04-01

    Kepler is the newest GPU architecture from NVIDIA, and the GTX 680 is the first commercially available graphics card based on that architecture. Matrix multiplication is a canonical computational kernel, and often the main target of initial optimization efforts for a new chip. This article presents preliminary results of automatically tuning matrix multiplication kernels for the Kepler architecture using the GTX 680 card.

  1. 76 FR 46270 - Certain Preserved Mushrooms From the People's Republic of China: Preliminary Results of...

    Science.gov (United States)

    2011-08-02

    .... See, e.g., Honey from the People's Republic of China: Preliminary Results and Partial Rescission of Antidumping Duty Administrative Review, 72 FR 102, 105 (January 3, 2007), unchanged in Honey from the People's... the domestic supplier to the factory that produced the subject merchandise or the distance from the...

  2. 78 FR 62584 - Certain Lined Paper Products From India: Preliminary Results of Countervailing Duty...

    Science.gov (United States)

    2013-10-22

    ... International Trade Administration Certain Lined Paper Products From India: Preliminary Results of... administrative review of the countervailing duty (CVD) order on certain lined paper products from India. The...., Washington, DC 20230; telephone (202) 482-1503. Scope of the Order The merchandise subject to the Lined Paper...

  3. 75 FR 977 - Carbazole Violet Pigment 23 From India: Preliminary Results of Countervailing Duty Administrative...

    Science.gov (United States)

    2010-01-07

    ... International Trade Administration Carbazole Violet Pigment 23 From India: Preliminary Results of Countervailing... pigment 23 (CVP-23) from India for the period January 1, 2007, through December 31, 2007. We preliminarily... Pigment 23 from India, 69 FR 77995 (December 29, 2004) (CVP-23 Order). On December 1, 2008, the Department...

  4. 75 FR 52930 - Carbazole Violet Pigment 23 From India: Preliminary Results of Antidumping Duty Changed...

    Science.gov (United States)

    2010-08-30

    ... International Trade Administration Carbazole Violet Pigment 23 From India: Preliminary Results of Antidumping... changed-circumstances review of the antidumping duty order on carbazole violet pigment 23 from India to determine whether Meghmani Pigments (Meghmani) is the successor-in-interest to Alpanil Industries (Alpanil...

  5. Preliminary results of the analysis of the population structure of the ...

    African Journals Online (AJOL)

    STORAGESEVER

    2008-08-18

    Aug 18, 2008 ... Preliminary results are provided of a study instituted to analyze the genetic population structure of the. Nile perch in ... differentiation between locations; however, the levels of genetic differentiation shown by the two loci were not enough to ... for a sport fishery on these waters (Hamblyn, 1961;. Eaffro, 1967 ...

  6. Specialized treatment for Avoidant personality disorder (AvPD): Treatment rationales and preliminary results

    DEFF Research Database (Denmark)

    Simonsen, Sebastian

    and preliminary results from a specialized psychotherapy program developed for patients with AvPD treated at Stolpegaard Psychotherapy Centre, Capital Region of Denmark. Methods: Treatment consists of individual therapy based on Metacognitive Interpersonal Therapy (MIT) while group therapy is a modified form...

  7. 77 FR 66580 - Certain Preserved Mushrooms From India: Preliminary Results of Antidumping Duty Administrative...

    Science.gov (United States)

    2012-11-06

    ... International Trade Administration Certain Preserved Mushrooms From India: Preliminary Results of Antidumping... review of the antidumping duty order on certain preserved mushrooms (mushrooms) from India. The period of... merchandise subject to the order is certain preserved mushrooms. The product is currently classified under the...

  8. 78 FR 1834 - Magnesium Metal From the People's Republic of China: Preliminary Results of Antidumping Duty...

    Science.gov (United States)

    2013-01-09

    ... International Trade Administration Magnesium Metal From the People's Republic of China: Preliminary Results of... administrative review of the antidumping duty order on magnesium metal from the People's Republic of China (``PRC... company, Tianjin Magnesium International, Co., Ltd. (``TMI''). The Department preliminarily finds that TMI...

  9. 78 FR 13321 - Silicon Metal From the People's Republic of China: Preliminary Results of Antidumping Duty...

    Science.gov (United States)

    2013-02-27

    ... International Trade Administration Silicon Metal From the People's Republic of China: Preliminary Results of... Commerce (``Department'') is conducting an administrative review of the antidumping duty order on silicon... notice of an opportunity to request an administrative review of the antidumping duty order on silicon...

  10. Preliminary results of the round-robin testing of F82H

    Energy Technology Data Exchange (ETDEWEB)

    Shiba, K.; Yamanouchi, N.; Tohyama, A.

    1996-10-01

    Preliminary results of metallurgical, physical and mechanical properties of low activation ferritic steel F82H (IEA heat) were obtained in the round-robin test in Japan. The properties of IEA heat F82H were almost the same as the original F82H.

  11. Preliminary results of robotic colorectal surgery at the National Cancer Institute, Cairo University

    Directory of Open Access Journals (Sweden)

    Ashraf Saad Zaghloul

    2016-09-01

    Conclusion: To the best of our knowledge, this is the first study reporting the outcomes of robotic colorectal cancer intervention in Egyptian patients. Our preliminary results suggest that robotic-assisted surgery for colorectal cancer can be carried out safely and according to oncological principles.

  12. 78 FR 4383 - Stainless Steel Bar From Brazil: Preliminary Results of Antidumping Duty Administrative Review...

    Science.gov (United States)

    2013-01-22

    ... International Trade Administration Stainless Steel Bar From Brazil: Preliminary Results of Antidumping Duty... the antidumping duty order on stainless steel bar (SSB) from Brazil. The period of review (POR) is... Antidumping Duty Administrative Review: Stainless Steel Bar from Brazil'' dated concurrently with this notice...

  13. 75 FR 67689 - Stainless Steel Bar From Brazil: Preliminary Results of Antidumping Duty Administrative Review

    Science.gov (United States)

    2010-11-03

    ... International Trade Administration Stainless Steel Bar From Brazil: Preliminary Results of Antidumping Duty... antidumping duty order on certain stainless steel bar from Brazil. The review covers one producer/ exporter of... Department published in the Federal Register an antidumping duty order on certain stainless steel bar from...

  14. 75 FR 12514 - Stainless Steel Bar From Brazil: Preliminary Results of Antidumping Duty Administrative Review

    Science.gov (United States)

    2010-03-16

    ... International Trade Administration Stainless Steel Bar From Brazil: Preliminary Results of Antidumping Duty... antidumping duty order on certain stainless steel bar from Brazil. The review covers one producer/ exporter of... Department published in the Federal Register an antidumping duty order on certain stainless steel bar from...

  15. 75 FR 81217 - Stainless Steel Plate in Coils From Belgium: Preliminary Results of Full Sunset Review

    Science.gov (United States)

    2010-12-27

    ... International Trade Administration Stainless Steel Plate in Coils From Belgium: Preliminary Results of Full... review of the countervailing duty (``CVD'') order on certain stainless steel plate in coils from Belgium... the domestic interested parties and adequate substantive responses from ArcelorMittal Stainless...

  16. 76 FR 19315 - Certain Orange Juice From Brazil: Preliminary Results of Antidumping Duty Administrative Review...

    Science.gov (United States)

    2011-04-07

    ... Agricultura (Fischer) and Sucocitrico Cutrale, S.A. (Cutrale). In Cutrale's request for an administrative... ``Calculations Performed for Fischer S.A. Comercio, Industria, and Agricultura for the Preliminary Results in the..., Industria and Agricultura.'' 2. Test of Comparison Market Sales Prices On a product-specific basis, we...

  17. 78 FR 34338 - Citric Acid and Certain Citrate Salts From Canada: Preliminary Results of Antidumping Duty...

    Science.gov (United States)

    2013-06-07

    ... International Trade Administration Citric Acid and Certain Citrate Salts From Canada: Preliminary Results of... administrative review of the antidumping duty order on citric acid and certain citrate salts (citric acid) from... is citric acid and certain citrate salts. The product is currently classified in the Harmonized...

  18. 78 FR 34648 - Citric Acid and Certain Citrate Salts: Preliminary Results of Countervailing Duty Administrative...

    Science.gov (United States)

    2013-06-10

    ... International Trade Administration Citric Acid and Certain Citrate Salts: Preliminary Results of Countervailing... review of the countervailing duty (CVD) order on citric acid and citrate salts from the People's Republic... (202) 482-1503. Scope of the Order The merchandise subject to the order is citric acid and certain...

  19. 76 FR 54202 - Honey From Argentina: Preliminary Results of Antidumping Duty New Shipper Review

    Science.gov (United States)

    2011-08-31

    ... International Trade Administration Honey From Argentina: Preliminary Results of Antidumping Duty New Shipper... antidumping duty order on honey from Argentina in response to a request from Villamora S.A. (Villamora), an... American Honey Producers Association and the Sioux Honey Association (collectively, petitioners). We...

  20. 76 FR 2655 - Honey From Argentina: Preliminary Results of Antidumping Duty Administrative Review

    Science.gov (United States)

    2011-01-14

    ... International Trade Administration Honey From Argentina: Preliminary Results of Antidumping Duty Administrative... conducting an administrative review of the antidumping duty order on honey from Argentina. The review covers... determine that sales of honey from Argentina have not been made below normal value (NV) by TransHoney S.A...

  1. 77 FR 46699 - Honey From the People's Republic of China: Preliminary Results of Review

    Science.gov (United States)

    2012-08-06

    ... International Trade Administration Honey From the People's Republic of China: Preliminary Results of Review... Peak Honey Industry Co., Ltd. (``Peak'') failed to cooperate to the best of its ability and is... administrative review of the antidumping duty order on honey from the People's Republic of China (``PRC...

  2. 77 FR 1458 - Honey From Argentina: Preliminary Results of Antidumping Duty Administrative Review and Partial...

    Science.gov (United States)

    2012-01-10

    ... International Trade Administration Honey From Argentina: Preliminary Results of Antidumping Duty Administrative... antidumping duty order on honey from Argentina. The review covers imports of subject merchandise from nine... determine that sales of honey from Argentina have not been made below normal value (NV) by mandatory...

  3. 78 FR 38941 - Honey From the People's Republic of China: Preliminary Results and Partial Rescission of...

    Science.gov (United States)

    2013-06-28

    ... International Trade Administration Honey From the People's Republic of China: Preliminary Results and Partial... Order The products covered by the order are natural honey, artificial honey containing more than 50 percent natural honey by weight, preparations of natural honey containing more than 50 percent natural...

  4. A Qualitative Study of Factors Influencing Racial Diversity in Environmental Education: Preliminary Results

    Science.gov (United States)

    Kathy James; Leo H. McAvoy

    1992-01-01

    This study presents preliminary result interviews with people of color working in environmental education and interpretation throughout the United States. The three primary questions asked were these? (1) What path led each individual to a career in environmental education; (2) How does each individual define environmentalism? and (3) What are the primary issues this...

  5. 78 FR 61331 - Freshwater Crawfish Tail Meat From the People's Republic of China: Preliminary Results of...

    Science.gov (United States)

    2013-10-03

    ... International Trade Administration Freshwater Crawfish Tail Meat From the People's Republic of China: Preliminary Results of Antidumping Duty Administrative Review and New Shipper Review; 2011-2012 AGENCY: Import... order on freshwater crawfish tail meat from the People's Republic of China (PRC). The period of review...

  6. Preliminary results of a battery-based, multi megawatt 200 kA pulsed power supply.

    NARCIS (Netherlands)

    Karthaus, W.; Kolkert, W.J.; Nowee, J.

    1989-01-01

    A pulsed power supply consisting of a fast discharge battery, a switch based on silicon-controlled-rectifier SCR technology, and an energy storage/pulse transformer is discussed. Preliminary results indicate that the battery is capable of discharging current pulses with reproducible peak values of

  7. 78 FR 34986 - Aluminum Extrusions From the People's Republic of China: Preliminary Results of Antidumping Duty...

    Science.gov (United States)

    2013-06-11

    ... Department applied a ``differential pricing'' analysis and has preliminarily determined to use the average-to... Department intends to disclose to the parties the calculations performed for these preliminary results within... rate calculation method adopted in Antidumping Proceedings: Calculation of the Weighted-Average Dumping...

  8. 78 FR 20615 - Drill Pipe From the People's Republic of China: Preliminary Results of Countervailing Duty...

    Science.gov (United States)

    2013-04-05

    ... International Trade Administration Drill Pipe From the People's Republic of China: Preliminary Results of... review of the countervailing duty (CVD) order on drill pipe from the People's Republic of China (PRC...-4793. Scope of the Order The scope of the order consists of steel drill pipe and steel drill collars...

  9. Longitudinal Twin Study of Early Reading Development in Three Countries: Preliminary Results.

    Science.gov (United States)

    Byrne, Brian; Delaland, Cara; Fielding-Barnsley, Ruth; Quain, Peter; Samuelsson, Stefan; Hoien, Torleiv; Corley, Robin; DeFries, John C.; Wadsworth, Sally; Willcutt, Erik; Olson, Richard K.

    2002-01-01

    Preliminary results from data on 146 Australian, 284 American, and 70 Norwegian preschool twins indicate reliable genetic influences on phonological awareness and memory and learning. Vocabulary, grammar, and morphology showed significant shared environment and negligible genetic effects. A print knowledge composite showed genetic and shared…

  10. 77 FR 73980 - Fresh Garlic From the People's Republic of China: Preliminary Results of Antidumping Duty...

    Science.gov (United States)

    2012-12-12

    ... International Trade Administration Fresh Garlic From the People's Republic of China: Preliminary Results of... administrative review (AR) of the antidumping duty order on fresh garlic from the People's Republic of China (PRC... withdrawn. See Fresh Garlic From the People's Republic of China: Partial Rescission of the 2010-2011...

  11. Comparative dosimetry in intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT for brain tumors

    Energy Technology Data Exchange (ETDEWEB)

    Brandao, Samia de Freitas, E-mail: samiabrandao@gmail.com [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Departamento de Engenharia Nuclear; Campos, Tarcisio Passos Ribeiro de [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil)

    2013-06-15

    Objective: comparative analysis of dosimetry in intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT for treatment of brain tumors. Materials and methods: simulations of intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT were performed with the MCNP5 code, modeling the treatment of a brain tumor on a voxel computational phantom representing a human head. Absorbed dose rates were converted into biologically weighted dose rates. Results: intracavitary balloon catheter brachytherapy with I-125 produced biologically weighted mean dose rates of 3.2E-11, 1.3E-10, 1.9E-11 and 6.9E-13 RBE.Gy.h{sup -1}.p{sup -1}.s, respectively, on the healthy tissue, on the balloon periphery and on the /{sub 1} and /{sub 2} tumor infiltration zones. On the other hand, Cf-252 brachytherapy combined with BNCT produced a biologically weighted mean dose rate of 5.2E-09, 2.3E-07, 8.7E-09 and 2.4E-09 RBE.Gy.h{sup -1}.p{sup -1}.s, respectively on the healthy tissue, on the target tumor and on the /{sub 1} and /{sub 2} infiltration zones. Conclusion: Cf-252 brachytherapy combined with BNCT delivered a selective irradiation to the target tumor and to infiltration zones, while intracavitary balloon catheter brachytherapy with I-125 delivered negligible doses on the tumor infiltration zones. (author)

  12. Comparative dosimetry in intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT for brain tumors

    Directory of Open Access Journals (Sweden)

    Samia de Freitas Brandao

    2013-07-01

    Full Text Available Objective Comparative analysis of dosimetry in intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT for treatment of brain tumors. Materials and Methods Simulations of intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT were performed with the MCNP5 code, modeling the treatment of a brain tumor on a voxel computational phantom representing a human head. Absorbed dose rates were converted into biologically weighted dose rates. Results Intracavitary balloon catheter brachytherapy with I-125 produced biologically weighted mean dose rates of 3.2E-11, 1.3E-10, 1.9E-11 and 6.9E-13 RBE.Gy.h-1.p-1.s, respectively, on the healthy tissue, on the balloon periphery and on the I 1 and I 2 tumor infiltration zones. On the other hand, Cf-252 brachytherapy combined with BNCT produced a biologically weighted mean dose rate of 5.2E-09, 2.3E-07, 8.7E-09 and 2.4E-09 RBE.Gy.h-1.p-1.s, respectively on the healthy tissue, on the target tumor and on the I 1 and I 2 infiltration zones. Conclusion Cf-252 brachytherapy combined with BNCT delivered a selective irradiation to the target tumor and to infiltration zones, while intracavitary balloon catheter brachytherapy with I-125 delivered negligible doses on the tumor infiltration zones.

  13. Late Urinary Side Effects 10 Years After Low-Dose-Rate Prostate Brachytherapy: Population-Based Results From a Multiphysician Practice Treating With a Standardized Protocol and Uniform Dosimetric Goals

    Energy Technology Data Exchange (ETDEWEB)

    Keyes, Mira, E-mail: mkeyes@bccancer.bc.ca; Miller, Stacy; Pickles, Tom; Halperin, Ross; Kwan, Winkle; Lapointe, Vincent; McKenzie, Michael; Spadinger, Ingrid; Pai, Howard; Chan, Elisa K.; Morris, W. James

    2014-11-01

    Purpose: To determine late urinary toxicity (>12 months) in a large cohort of uniformly treated low-dose-rate prostate brachytherapy patients. Methods and Materials: From 1998 to 2009, 2709 patients with National Comprehensive Cancer Network–defined low-risk and low-tier intermediate-risk prostate cancer were treated with Iodine 125 ({sup 125}I) low-dose-rate prostate brachytherapy; 2011 patients with a minimum of 25 months of follow-up were included in the study. Baseline patients, treatment, implant factors, and late urinary toxicity (Radiation Therapy Oncology Group [RTOG] grading system and International Prostate Symptom Score [IPSS]) were recorded prospectively. Time to IPSS resolution, late RTOG genitourinary toxicity was examined with Kaplan-Meier and log-rank tests. Cox proportional hazards regression was done for individual covariates and multivariable models. Results: Median follow-up was 54.5 months (range, 2-13 years). Actuarial toxicity rates reached 27% and 10% (RTOG ≥2 and ≥3, respectively) at 9-13 years. Symptoms resolved quickly in the majority of patients (88% in 6-12 months). The prevalence of RTOG 0, 1, 2, 3, and 4 toxicity with a minimum of 7 years' follow-up was 70%, 21%, 6.4%, 2.3%, and 0.08%, respectively. Patients with a larger prostate volume, higher baseline IPSS, higher D90, acute toxicity, and age >70 years had more late RTOG ≥2 toxicity (all P≤.02). The IPSS resolved slower in patients with lower baseline IPSS and larger ultrasound prostate volume, those not receiving androgen deprivation therapy, and those with higher D90. The crude rate of RTOG 3 toxicity was 6%. Overall the rate of transurethral resection of the prostate was 1.9%; strictures, 2%; incontinence, 1.3%; severe symptoms, 1.8%; late catheterization, 1.3%; and hematuria, 0.8%. The majority (80%) resolved their symptoms in 6-12 months. Conclusion: Long-term urinary toxicity after brachytherapy is low. Although actuarial rates increase with longer

  14. SU-F-T-17: A Feasibility Study for the Transit Dosimetry with a Glass Dosimeter in Brachytherapy

    Energy Technology Data Exchange (ETDEWEB)

    Moon, S; Yoon, M [Korea University, Seoul (Korea, Republic of); Chung, W; Chung, M; Kim, D [Kyung Hee University Hospital at Gangdong, Gangdonggu, Seoul (Korea, Republic of)

    2016-06-15

    Purpose: Confirming the dose delivered to a patient is important to make sure the treatment quality and safety of the radiotherapy. Measuring a transit dose of the patient during the radiotherapy could be an interesting way to confirm the patient dose. In this study, we evaluated the feasibility of the transit dosimetry with a glass dosimeter in brachytherapy. Methods: We made a phantom that inserted the glass dosimeters and placed under patient lying on a couch for cervix cancer brachytherapy. The 18 glass dosimeters were placed in the phantom arranged 6 per row. A point putting 1cm vertically from the source was prescribed as 500.00 cGy. Solid phantoms of 0, 2, 4, 6, 8, 10 cm were placed between the source and the glass dosimeter. The transit dose was measured each thickness using the glass dosimeters and compared with a treatment planning system (TPS). Results: When the transit dose was smaller than 10 cGy, the average of the differences between measured values and calculated values by TPS was 0.50 cGy and the standard deviation was 0.69 cGy. If the transit dose was smaller than 100 cGy, the average of the error was 1.67 ± 4.01 cGy. The error to a point near the prescription point was −14.02 cGy per 500.00 cGy of the prescription dose. Conclusion: The distances from the sources to skin of the patient generally are within 10 cm for cervix cancer cases in brachytherapy. The results of this preliminary study showed the probability of the glass dosimeter as the transit dosimeter in brachytherapy.

  15. Trends in the Utilization of Brachytherapy in Cervical Cancer in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Han, Kathy, E-mail: Kathy.Han@rmp.uhn.on.ca [Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario (Canada); Milosevic, Michael; Fyles, Anthony [Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario (Canada); Pintilie, Melania [Department of Biostatistics, Princess Margaret Hospital, Toronto, Ontario (Canada); Viswanathan, Akila N. [Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women' s Hospital, Boston, Massachusetts (United States)

    2013-09-01

    Purpose: To determine the trends in brachytherapy use in cervical cancer in the United States and to identify factors and survival benefits associated with brachytherapy treatment. Methods and Materials: Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified 7359 patients with stages IB2-IVA cervical cancer treated with external beam radiation therapy (EBRT) between 1988 and 2009. Propensity score matching was used to adjust for differences between patients who received brachytherapy and those who did not from 2000 onward (after the National Cancer Institute alert recommending concurrent chemotherapy). Results: Sixty-three percent of the 7359 women received brachytherapy in combination with EBRT, and 37% received EBRT alone. The brachytherapy utilization rate has decreased from 83% in 1988 to 58% in 2009 (P<.001), with a sharp decline of 23% in 2003 to 43%. Factors associated with higher odds of brachytherapy use include younger age, married (vs single) patients, earlier years of diagnosis, earlier stage and certain SEER regions. In the propensity score-matched cohort, brachytherapy treatment was associated with higher 4-year cause-specific survival (CSS; 64.3% vs 51.5%, P<.001) and overall survival (OS; 58.2% vs 46.2%, P<.001). Brachytherapy treatment was independently associated with better CSS (hazard ratio [HR], 0.64; 95% confidence interval [CI], 0.57-0.71), and OS (HR 0.66; 95% CI, 0.60 to 0.74). Conclusions: This population-based analysis reveals a concerning decline in brachytherapy utilization and significant geographic disparities in the delivery of brachytherapy in the United States. Brachytherapy use is independently associated with significantly higher CSS and OS and should be implemented in all feasible cases.

  16. Preliminary results of V440 Per and α UMi observations with the Poznan Spectroscopic Telescope

    Science.gov (United States)

    Fagas, M.; Baranowski, R.; Bartczak, P.; Borczyk, W.; Dimitrow, W.; Kaminski, K.; Kwiatkowski, T.; Ratajczak, R.; Rozek, A.; Schwarzenberg-Czerny, A.

    2009-03-01

    Presented herein are preliminary radial velocity results for two classical Cepheids: V440 Per and α UMi (Polaris). Both stars have been observed with the Poznan Spectroscopic Telescope (PST), operational since Aug 2007 at the Borowiec Station of Poznań Astronomical Observatory in Poland. Data obtained for V440 Per suggest the presence of a low-amplitude secondary mode of pulsations. Results of α UMi observations confirm further pulsation amplitude growth, as observed during the last decades.

  17. Preliminary results of natural radioactivity measurements in the southern part of Ethiopia

    Energy Technology Data Exchange (ETDEWEB)

    Wollel Tiruneh, Getachew [Ethiopian Radiation Protection Authority, PO Box 20486 code 1000, Addis-Ababa (Ethiopia)], E-mail: gwollel@yahoo.com; Wodaje Kebede, Worku [Ethiopian Radiation Protection Authority, PO Box 20486 code 1000, Addis-Ababa (Ethiopia)

    2008-11-15

    The paper presents the first results of natural radioactivity measurements in the Southern part of Ethiopia (Bale Zone-Oromiya Regional State). The preliminary results indicate that radiation levels in the mining areas of Kallido Mountain are elevated compared with those in the town of Negele Borena (background area). Both external gamma radiation and alpha surface contamination levels are significantly elevated above local background levels.

  18. (106)Ruthenium brachytherapy for retinoblastoma.

    Science.gov (United States)

    Abouzeid, Hana; Moeckli, Raphaël; Gaillard, Marie-Claire; Beck-Popovic, Maja; Pica, Alessia; Zografos, Leonidas; Balmer, Aubin; Pampallona, Sandro; Munier, Francis L

    2008-07-01

    To evaluate the efficacy of (106)Ru plaque brachytherapy for the treatment of retinoblastoma. We reviewed a retrospective, noncomparative case series of 39 children with retinoblastoma treated with (106)Ru plaques at the Jules-Gonin Eye Hospital between October 1992 and July 2006, with 12 months of follow-up. A total of 63 tumors were treated with (106)Ru brachytherapy in 41 eyes. The median patient age was 27 months. (106)Ru brachytherapy was the first-line treatment for 3 tumors (4.8%), second-line treatment for 13 (20.6%), and salvage treatment for 47 tumors (74.6%) resistant to other treatment modalities. Overall tumor control was achieved in 73% at 1 year. Tumor recurrence at 12 months was observed in 2 (12.5%) of 16 tumors for which (106)Ru brachytherapy was used as the first- or second-line treatment and in 15 (31.9%) of 47 tumors for which (106)Ru brachytherapy was used as salvage treatment. Eye retention was achieved in 76% of cases (31 of 41 eyes). Univariate and multivariate analyses revealed no statistically significant risk factors for tumor recurrence. Radiation complications included retinal detachment in 7 (17.1%), proliferative retinopathy in 1 (2.4%), and subcapsular cataract in 4 (9.7%) of 41 eyes. (106)Ru brachytherapy is an effective treatment for retinoblastoma, with few secondary complications. Local vitreous seeding can be successfully treated with (106)Ru brachytherapy.

  19. The RPC-based IFR system at BaBar experiment preliminary results

    CERN Document Server

    Piccolo, D; Bagnasco, S; Baldini, R; Band, H R; Bionta, R; Buzzo, A; Calcaterra, A; Cavallo, N; Contri, R; Crosetti, G; De Nardo, Gallieno; De Sangro, R; Fabozzi, F; Falciai, D; Finocchiaro, G; Gatto, C; Johnson, J; Lista, L; Lo Vetere, M; Macri, M; Monge, R; Palano, A; Paolucci, P; Passaggio, S; Patrignani, C; Patteri, P; Peruzzi, I; Piccolo, M; Robutti, E; Santroni, A; Sciacca, C; Wright, D; Yu, Z; Zallo, A

    2002-01-01

    The IFR system is a RPC-based detector used to identify muons and neutral hadrons in the BaBar experiment at PEP II machine in SLAC. The RPC system can be used to reconstruct the trajectory of muons, pions and neutral hadrons interacting in the iron of the IFR. The different range and hit pattern allow to discriminate different particles crossing the IFR. An overview of the system design and the preliminary results on the IFR performances are reported.

  20. Facial emotional recognition in schizophrenia: preliminary results of the virtual reality program for facial emotional recognition

    OpenAIRE

    Souto,Teresa; Baptista,Alexandre; Tavares,Diana; Queirós,Cristina; António,Marques

    2013-01-01

    BACKGROUND: Significant deficits in emotional recognition and social perception characterize patients with schizophrenia and have direct negative impact both in inter-personal relationships and in social functioning. Virtual reality, as a methodological resource, might have a high potential for assessment and training skills in people suffering from mental illness. OBJECTIVES: To present preliminary results of a facial emotional recognition assessment designed for patients with schizophrenia,...

  1. SPANISH MULTICENTRIC STUDY ABOUT NUTRITION-INFLAMATIONhn WITH MID DILUTION (ENIMID STUDY: PRELIMINARY RESULTS

    Directory of Open Access Journals (Sweden)

    Barril G

    2012-06-01

    CONCLUSIONS: 1-The preliminary results show that MidDilution provides a good removal of small and middle molecules, increases appetite by providing a proper balance of cytokines through stimulation of antiinflamatory ones and neuropeptide Y. 2-It provides an improvement of body composition. Finally MidDilution improves nutritional parameters which leads to a better quality of life, as well as physical and mental status.

  2. Preliminary results of new 50 MHz doppler radar experiment at Syowa Station

    OpenAIRE

    Ogawa,Tadahiko; Igarashi,Kiyoshi; Ose,Masami; Kuratani,Yasukazu; Fujii,Ryoichi; Hirasawa,Takeo

    1983-01-01

    A 50 MHz doppler radar newly installed at Syowa Station in 1982 is characterized by the narrow antenna beams (4°in the horizontal plane) in two different directions (approximately geomagnetic and geographic south), the three operation modes (spectrum, double-pulse and meteor mode) and the minicomputer for both real time data processing and radar control. This paper aims to check up many functions given to the radar system by presenting some preliminary results obtained at a very early stage o...

  3. Design and optimization of a brachytherapy robot

    Science.gov (United States)

    Meltsner, Michael A.

    Trans-rectal ultrasound guided (TRUS) low dose rate (LDR) interstitial brachytherapy has become a popular procedure for the treatment of prostate cancer, the most common type of non-skin cancer among men. The current TRUS technique of LDR implantation may result in less than ideal coverage of the tumor with increased risk of negative response such as rectal toxicity and urinary retention. This technique is limited by the skill of the physician performing the implant, the accuracy of needle localization, and the inherent weaknesses of the procedure itself. The treatment may require 100 or more sources and 25 needles, compounding the inaccuracy of the needle localization procedure. A robot designed for prostate brachytherapy may increase the accuracy of needle placement while minimizing the effect of physician technique in the TRUS procedure. Furthermore, a robot may improve associated toxicities by utilizing angled insertions and freeing implantations from constraints applied by the 0.5 cm-spaced template used in the TRUS method. Within our group, Lin et al. have designed a new type of LDR source. The "directional" source is a seed designed to be partially shielded. Thus, a directional, or anisotropic, source does not emit radiation in all directions. The source can be oriented to irradiate cancerous tissues while sparing normal ones. This type of source necessitates a new, highly accurate method for localization in 6 degrees of freedom. A robot is the best way to accomplish this task accurately. The following presentation of work describes the invention and optimization of a new prostate brachytherapy robot that fulfills these goals. Furthermore, some research has been dedicated to the use of the robot to perform needle insertion tasks (brachytherapy, biopsy, RF ablation, etc.) in nearly any other soft tissue in the body. This can be accomplished with the robot combined with automatic, magnetic tracking.

  4. 76 FR 65172 - Fresh Garlic From the People's Republic of China: Partial Preliminary Results, Rescission of, and...

    Science.gov (United States)

    2011-10-20

    ... International Trade Administration Fresh Garlic From the People's Republic of China: Partial Preliminary Results... antidumping duty order on fresh garlic from the People's Republic of China (PRC) covering the period of review... Information for Partial Preliminary Results of Administrative Review for Fresh Garlic from the People's...

  5. An Active Mammosite For Breast Brachytherapy

    Science.gov (United States)

    Cudjoe, Thomas

    2006-03-01

    Brachytherapy is an advanced cancer treatment that uses radioactive sources inside or in close proximity to cancerous tumors, thus minimizing exposure to neighboring healthy cells. This radiation oncology treatment unlike many others is localized and precise. The latest involvement of the Brachytherapy research group of the medical physics program at Hampton University is in the development of a scintillator fiber based detector for the breast cancer specific Mammosite (balloon device) from Cytyc Inc. Radioactive sources are inserted into a small plastic catheter (shaft) and pushed at the end of the tube. At that location, a water filled balloon surrounds the source and allow uniform gamma emission into cancer tumors. There is presently no capability for this device to provide measurements of the location of the source, as well as the radiation emitted from the source. Recent data were acquired to evaluate the possibility of measuring the dose distribution during breast Brachytherapy cancer treatments with this device. A high activity ^192Ir radioactive source and a 0.5 and 1 mm^2 scintillating fibers were used. Results will be presented and discussed.

  6. Preliminary results of an extensive study of fragmentation measurements for medical and space applications

    CERN Document Server

    Agodi, C; Calabretta, L; Cirrone, G A P C; Cuttone, G; De Napoli, M; Fiorini, F; Giacoppo, F; Mairani, A; Morone, M C; Patera, V; Raciti, G; Rapisarda, E; Ricciardi, V; Romano, F; Sala, P; Sciubba, A

    2010-01-01

    Here we report on preliminary results of an extensive study of fragmentation cross sections measurements useful for medical and space applications. In particular, we looked at the hadrontherapy and space radiation research. Indeed, the measure of fragmentation cross sections is an important information to estimate how this process modifies dose distributions and biological effectiveness, both inside human body and spacecraft. In this picture we started to measure the fragmentation of 12C beam accelerated by the Superconducting Cyclotron at 32 AMeV, 62 AMeV on 12C, 207Pb and 197Au at the INFN Laboratory Nazionali del Sud in Catania (Italy). Preliminary comparison between absolute cross-sections measured for the systems: 12C+207Pb at 32AMeV and for 12C+197Au at 62AMeV is performed.

  7. Late side-effects and cosmetic results of accelerated partial breast irradiation with interstitial brachytherapy versus whole-breast irradiation after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: 5-year results of a randomised, controlled, phase 3 trial.

    Science.gov (United States)

    Polgár, Csaba; Ott, Oliver J; Hildebrandt, Guido; Kauer-Dorner, Daniela; Knauerhase, Hellen; Major, Tibor; Lyczek, Jaroslaw; Guinot, José Luis; Dunst, Jürgen; Miguelez, Cristina Gutierrez; Slampa, Pavel; Allgäuer, Michael; Lössl, Kristina; Polat, Bülent; Kovács, György; Fischedick, Arnt-René; Fietkau, Rainer; Resch, Alexandra; Kulik, Anna; Arribas, Leo; Niehoff, Peter; Guedea, Ferran; Schlamann, Annika; Pötter, Richard; Gall, Christine; Uter, Wolfgang; Strnad, Vratislav

    2017-02-01

    We previously confirmed the non-inferiority of accelerated partial breast irradiation (APBI) with interstitial brachytherapy in terms of local control and overall survival compared with whole-breast irradiation for patients with early-stage breast cancer who underwent breast-conserving surgery in a phase 3 randomised trial. Here, we present the 5-year late side-effects and cosmetic results of the trial. We did this randomised, controlled, phase 3 trial at 16 centres in seven European countries. Women aged 40 years or older with stage 0-IIA breast cancer who underwent breast-conserving surgery with microscopically clear resection margins of at least 2 mm were randomly assigned 1:1, via an online interface, to receive either whole-breast irradiation of 50 Gy with a tumour-bed boost of 10 Gy or APBI with interstitial brachytherapy. Randomisation was stratified by study centre, menopausal status, and tumour type (invasive carcinoma vs ductal carcinoma in situ), with a block size of ten, according to an automated dynamic algorithm. Patients and investigators were not masked to treatment allocation. The primary endpoint of our initial analysis was ipsilateral local recurrence; here, we report the secondary endpoints of late side-effects and cosmesis. We analysed physician-scored late toxicities and patient-scored and physician-scored cosmetic results from the date of breast-conserving surgery to the date of onset of event. Analysis was done according to treatment received (as-treated population). This trial is registered with ClinicalTrials.gov, number NCT00402519. Between April 20, 2004, and July 30, 2009, we randomly assigned 1328 women to receive either whole-breast irradiation (n=673) or APBI with interstitial brachytherapy (n=655); 1184 patients comprised the as-treated population (551 in the whole-breast irradiation group and 633 in the APBI group). At a median follow-up of 6·6 years (IQR 5·8-7·6), no patients had any grade 4 toxities, and three (cosmetic

  8. Comparison of the Results of Serum Total Protein Concentration Measured by 3 Methods: Preliminary Results

    OpenAIRE

    GEORGIEVA, Teodora M.; ZAPRYANOVA, Dimitrinka S.

    2009-01-01

    The present study provides the results from a comparative study of the 3 commonly used methods for total protein (TP) measurement. The experiments were carried out with 6 dogs (4-7 year-old, weighing 12.8 ± 1.4 kg). Five blood samples were obtained by saphena venepuncture from all dogs, during the time course of the experimentally induced infection with Staphylococcus intermedius, administered subcutaneously at a dose rate of 5 ml of 1.109 CFU/ml within 14 days. TP concentration was measured ...

  9. Brachytherapy with an improved MammoSite Radiation Therapy System

    Science.gov (United States)

    Karthik, Nanda; Keppel, Cynthia; Nazaryan, Vahagn

    2007-03-01

    Accelerated partial breast irradiation treatment utilizing the MammoSite Radiation Therapy System (MRTS) is becoming increasingly popular. Clinical studies show excellent results for disease control and localization, as well as for cosmesis. Several Phase I, II, and III clinical trials have found significant association between skin spacing and cosmetic results after treatment with MRTS. As a result, patients with skin spacing less then 7 mm are not recommended to undergo this treatment. We have developed a practical innovation to the MammoSite brachytherapy methodology that is directed to overcome the skin spacing problem. The idea is to partially shield the radiation dose to the skin where the skin spacing is less then 7 mm, thereby protecting the skin from radiation damage. Our innovation to the MRTS will allow better cosmetic outcome in breast conserving therapy (BCT), and will furthermore allow more women to take advantage of BCT. Reduction in skin radiation exposure is particularly important for patients also undergoing adjuvant chemotherapy. We will present the method and preliminary laboratory and Monte Carlo simulation results.

  10. Cation dynamics of molecular Hydrogen in the presence of a strong laser field, preliminary results

    Science.gov (United States)

    Gatton, A.; Champenois, E.; Larsen, K.; Shivaram, N.; Bakhti, S.; Iskander, W.; Sievert, T.; Reedy, D.; Weller, M.; Williams, J. B.; Landers, A.; Weber, Th.

    2017-04-01

    We present preliminary results from a new 2-color laser+synchrotron Cold Target Recoil Ion Momentum Spectrometer (COLTRIMS) experiment in which we overlap a pulsed laser (1030 nm , 12 ps , 5 *1011 W / cm2) with light from beamline 10 . 0 . 1 (18 . 56 eV , 80 ps , 50 meV resolution) at the Advanced Light Source at Lawrence Berkeley National Lab. The data (absent the laser) shows asymmetric proton emission in the fragmenting hydrogen cation due to the retro-action of the photoelectron Coulomb potential, as reported recently by Waitz et al.. Preliminary analysis hints that this effect exists and may even be enhanced in the laser dressed states of the dissociating cation. Of even more interest, preliminary analysis hints at the signature of light induced conical intersections in the dissociation of the laser dressed hydrogen cations, as recently reported by Natan et al.. This research used the Advanced Light Source and was supported by DOE-BES under contract No. DE-AC02-05CH11231 and DE-FG02-86ER13491, the ALS Doctoral Fellowship in Residence, and the DFG and DAAD.

  11. [Operative treatment of flexor pollicis longus tendon with Krackow suture, functional results--preliminary results].

    Science.gov (United States)

    Bumbasirević, Marko Z; Andjelković, Sladjana; Lesić, Aleksandar R; Sudjić, Vojo S; Palibrk, Tomislav; Tulić, Goran Dz; Radenković, Dejan V; Bajec, Djordje D

    2010-01-01

    Surgical treatment of the injuried flexor tensons is the important part of hand surgery. Tendon adhesions, ruptures, joint contcatures-stifness are only one part of the problem one is faced during the tendon treatment. In spite of improvement in surgical technique and suture material, the end result of sutured flexor tendons still represent a serious problem. To present of operative treatment of flexor pollicis longus injury with Krakow suture technique. All patients are treated in the first 48 hours after the accident. The regional anesthesia was performed with use of turniquet. Beside spare debridement, the reconstruction of digital nerves was done. All patients started with active and pasive movements-excercises on the first postoperative day. Follow-up was from 6 to 24 months. In evaluation of functional recovery the grip strenght, pinch strenght, range of movements of interphalangeal and metacarpophalangeal joiht and DASH score were used. In the last two years there were 30 patients, 25 males (83.33%) and 5 females (16.66%). Mean age was 39.8 years, ranged from 17 to 65 years. According to mechanism of injury the patients were divided in two groups: one with sharp and other with wider zone of injury. Concomitant digital nerve lesions was noticed in 15 patients (50%). the Krackow sutrue allowed early rehabilitation, which prevent tendon adhesions, enabled faster and better functional recovery.

  12. Contemporary Toxicity Profile of Breast Brachytherapy Versus External Beam Radiation After Lumpectomy for Breast Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Huo, Jinhai [Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Giordano, Sharon H. [Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Smith, Benjamin D. [Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Shaitelman, Simona F. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Smith, Grace L., E-mail: glsmith@mdanderson.org [Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2016-03-15

    Purpose: We compared toxicities after brachytherapy versus external beam radiation therapy (EBRT) in contemporary breast cancer patients. Methods and Materials: Using MarketScan healthcare claims, we identified 64,112 women treated from 2003 to 2012 with lumpectomy followed by radiation (brachytherapy vs EBRT). Brachytherapy was further classified by multichannel versus single-channel applicator approach. We identified the risks and predictors of 1-year infectious and noninfectious postoperative adverse events using logistic regression and temporal trends using Cochran-Armitage tests. We estimated the 5-year Kaplan-Meier cumulative incidence of radiation-associated adverse events. Results: A total of 4522 (7.1%) patients received brachytherapy (50.2% multichannel vs 48.7% single-channel applicator). The overall risk of infectious adverse events was higher after brachytherapy than after EBRT (odds ratio [OR] = 1.21; 95% confidence interval [CI] 1.09-1.34, P<.001). However, over time, the frequency of infectious adverse events after brachytherapy decreased, from 17.3% in 2003 to 11.6% in 2012, and was stable after EBRT at 9.7%. Beyond 2007, there were no longer excess infections with brachytherapy (P=.97). The overall risk of noninfectious adverse events was higher after brachytherapy than after EBRT (OR=2.27; 95% CI 2.09-2.47, P<.0001). Over time, the frequency of noninfectious adverse events detected increased: after multichannel brachytherapy, from 9.1% in 2004 to 18.9% in 2012 (Ptrend = .64); single-channel brachytherapy, from 12.8% to 29.8% (Ptrend<.001); and EBRT, from 6.1% to 10.3% (Ptrend<.0001). The risk was significantly higher with single-channel than with multichannel brachytherapy (hazard ratio = 1.32; 95% CI 1.03-1.69, P=.03). Of noninfectious adverse events, 70.9% were seroma. Seroma significantly increased breast pain risk (P<.0001). Patients with underlying diabetes, cardiovascular disease, and treatment with chemotherapy had increased

  13. Utilization and Outcomes of Breast Brachytherapy in Younger Women

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Grace L. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Huo, Jinhai [Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Giordano, Sharon H. [Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Hunt, Kelly K. [Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Buchholz, Thomas A. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Smith, Benjamin D., E-mail: bsmith3@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2015-09-01

    Purpose: To directly compare (1) radiation treatment utilization patterns; (2) risks of subsequent mastectomy; and (3) costs of radiation treatment in patients treated with brachytherapy versus whole-breast irradiation (WBI), in a national, contemporary cohort of women with incident breast cancer, aged 64 years and younger. Methods and Materials: Using MarketScan health care claims data, we identified 45,884 invasive breast cancer patients (aged 18-64 years), treated from 2003 to 2010 with lumpectomy, followed by brachytherapy (n=3134) or whole-breast irradiation (n=42,750). We stratified patients into risk groups according to age (Age<50 vs Age≥50) and endocrine therapy status (Endocrine− vs Endocrine+). “Endocrine+” patients filled an endocrine therapy prescription within 1 year after lumpectomy. Pathologic hormone receptor status was not available in this dataset. In brachytherapy versus WBI patients, utilization trends and 5-year subsequent mastectomy risks were compared. Stratified, adjusted subsequent mastectomy risks were calculated using proportional hazards regression. Results: Brachytherapy utilization increased from 2003 to 2010: in patients Age<50, from 0.6% to 4.9%; patients Age≥50 from 2.2% to 11.3%; Endocrine− patients, 1.3% to 9.4%; Endocrine+ patients, 1.9% to 9.7%. Age influenced treatment selection more than endocrine status: 17% of brachytherapy patients were Age<50 versus 32% of WBI patients (P<.001); whereas 41% of brachytherapy patients were Endocrine–versus 44% of WBI patients (P=.003). Highest absolute 5-year subsequent mastectomy risks occurred in Endocrine−/Age<50 patients (24.4% after brachytherapy vs 9.0% after WBI (hazard ratio [HR] 2.18, 95% confidence interval [CI] 1.37-3.47); intermediate risks in Endocrine−/Age≥50 patients (8.6% vs 4.9%; HR 1.76, 95% CI 1.26-2.46); and lowest risks in Endocrine+ patients of any age: Endocrine+/Age<50 (5.5% vs 4.5%; HR 1.18, 95% CI 0.61-2.31); Endocrine+/Age≥50 (4.2% vs 2

  14. Preliminary Experimental Results for Indirect Vector-Control of Induction Motor Drives with Forced Dynamics

    Directory of Open Access Journals (Sweden)

    Jan Vittek

    2003-01-01

    Full Text Available The contribution presents an extension of indirect vector control of electric drives employing induction motors to 'Forced Dynamic Control'. This method of control offers an accurate realisation of dynamic response profiles, which can be selected by the user. The developed system can be integrated into a drive with a shaft position encoder or a shaft sensoriess drive, in which only the stator currents are measured. The applied stator voltages are determined by a computed inverter switching algorithm. Simulation results and preliminary experimental results for indirect vector control of an idle running induction motor indicate good agreement with the theoretical predictions.

  15. Modelled and Observed Diurnal SST Signals: "SSTDV:R.EX.-IM.A.M." Project Preliminary Results

    DEFF Research Database (Denmark)

    Karagali, Ioanna; Høyer, Jacob; LeBorgne, Pierre

    2013-01-01

    This study presents some of the preliminary results from the ESA Support To Science Element (STSE) funded project on the Diurnal Variability of the Sea Surface Temperature, regarding its Regional Extend and Implications in Atmospheric Modelling (SSTDV:R.EX.–IM.A.M.). During this phase...... of the project, the focus is on the regional extend of diurnal variability. Particularly, extensive sensitivity tests regarding the definition of SSTfound fields show that using only quality 5 SEVIRI data results in warmer foundation fields SSTfound while there is an added ∼0.2 K variability when using multi...

  16. Mass transport phenomena in microgravity: Preliminary results of the first MEPHISTO flight experiment

    Science.gov (United States)

    Favier, Jean Jacques; Garandet, J. P.; Rouzaud, A.; Camel, D.

    1994-01-01

    The MEPHISTO space program is the result of a cooperative effort that involves the French nuclear and space agencies (Commissariat a l'energie atomique, CEA - Centre National d'Etudes Spatiales, CNES) and the American National Aeronautics and Space Administration (NASA). The scientific studies and apparatus development were funded in the frame of the GRAMME agreement between CEA and CNES, the flight costs being taken in charge by NASA. Six flight opportunities are scheduled, with alternating French and American principal investigators. It is the purpose of this paper to briefly present MEPHISTO along with the preliminary results obtained during its first flight on USMP-1 in October 1992.

  17. Interfraction accumulation of seroma during accelerated partial breast irradiation: preliminary results of a prospective study.

    Science.gov (United States)

    Bhatt, Aashish D; Crew, John B; Bhatt, Geetika; Johnson, Robert R; Sowards, Keith T; Pan, Jianmin; Dragun, Anthony E

    2012-01-01

    To quantify and characterize the process of seroma accumulation during accelerated partial breast irradiation using multicatheter balloon brachytherapy. Twenty-two patients were treated using the Contura Multilumen brachytherapy catheter to a dose of 34Gy in 10 fractions over 5 treatment days. Serial aspirations of the vacuum port of the catheter were performed at the time of CT simulation and before each treatment. Volume and characteristics of fluid drawn were recorded. Univariate analysis was performed to evaluate various factors predictive of seroma formation. Median patient age was 59.5 years, body mass index was 31, and volume of surgical specimen was 62.4cm(3). Median time from breast conservation surgery to placement of Contura catheter was 18.5 days. Pericatheter seroma, typically scant with a median volume of 0.75mL, was noted in 91% of patients at CT simulation. A total of 203 aspirations were performed with a median-aspirated seroma volume of 4.05mL. There was no significant correlation between the volume of seroma and histology (invasive vs. in situ), quadrant of location, body mass index, reexcision or reoperation, days from breast conservation surgery to balloon placement, or the volume of specimen removed. Radiation treatment factors, including balloon volume, balloon to skin distance, and planning target volume evaluation, also did not correlate with aspirated seroma. Interfraction seroma accumulation has a variable pattern of development with no discernible predictors of occurrence. Routine pretreatment aspirations via vacuum port may potentially improve dosimetric reproducibility for a minority of patients. Copyright © 2012 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

  18. Preliminary

    Directory of Open Access Journals (Sweden)

    Abeer M. Ismail

    2016-06-01

    Full Text Available Phytochemical analysis of the methanolic and aqueous extracts of Faidherbia albida legumes indicated the presence of terpenes, cardiac glycosides, monosaccharides and carbohydrates type of compounds in both extracts. While alkaloids and saponins were found in aqueous extract only, flavonoids were found to be absent in both extracts. The aqueous and methanolic extracts exhibited a potent growth stimulation effect. Inhibition of both the rootlet and shoot showed a dose dependent response. Aqueous extract has a greater inhibitory effect on rootlet growth than shoot growth. The methanolic extract has a greater inhibitory effect than the aqueous extract. Both extracts and some fractions were tested against three pathogenic bacterial species; Staphylococcus aureus, Escherichia coli and Shigella dysenteriae, also tested against three pathogenic fungal species; Fusarium oxysporum, Alternaria alternate, and Aspergillus niger. Most of the plant extracts stimulate the studied fungal growth specially the aqueous extract. Meanwhile it shows interesting results by inhibiting the growth of the studied pathogenic bacterial species with most extracts and fractions.

  19. Photon Sources for Brachytherapy

    Science.gov (United States)

    Rijnders, Alex

    As introduction a short overview of the history of brachytherapy (BT) is given, with a focus on the evolution in the photon sources that have been used over the years. A major step in this evolution was the introduction of the automatic afterloading devices, which could be compared to the introduction of linear accelerators in external beam radiotherapy (EBRT). The modern afterloaders allow for optimization of the dose delivery and the use of different dose rates (low dose rate, high dose rate and pulsed dose rate) in function of tumor biology and patient comfort. Still today new sources are under investigation, and these developments together with the improvements in treatment planning and treatment techniques will enforce the role and place of BT as a valuable alternative for or supplementary to EBRT.

  20. A comparison of complication rates in early-stage breast cancer patients treated with brachytherapy versus whole-breast irradiation.

    Science.gov (United States)

    Ajkay, Nicolas; Collett, Abigail E; Bloomquist, Erica V; Gracely, Edward J; Frazier, Thomas G; Barrio, Andrea V

    2015-04-01

    The adoption of breast brachytherapy into clinical practice for early-stage breast cancer has increased over the last several years. Studies evaluating complication rates following treatment with brachytherapy have shown conflicting results. We compared local toxicity in patients treated with brachytherapy with those treated with whole-breast irradiation (WBI). We identified 417 early-stage breast cancer patients treated with breast-conserving surgery and radiation between 2004 and 2010, and compared 271 women treated with intracavitary brachytherapy with 146 women treated with WBI. Long-term complications were assessed using Kaplan-Meier curves with the log-rank test. Median follow-up was 4.6 years, and the 5-year incidence of infectious skin complications (9.7 vs. 11.0 %, p = 0.84), abscess (1.1 vs. 0 %, p = 0.15), telangiectasia (8.0 vs. 5.3 %, p = 0.35), and breast pain (14.2 vs. 9.4 %, p = 0.2) was similar between the brachytherapy and WBI cohorts. The brachytherapy cohort had a higher 5-year rate of seroma (46.5 vs. 18.5 %, p Brachytherapy patients trended towards more frequent biopsies as a result of fat necrosis to rule out a recurrence (11.2 vs. 6.7 %, p = 0.13). Patients treated with intracavitary brachytherapy had more local toxicity, particularly seroma and fat necrosis. Patients should be counseled on the possible increased rate of long-term complications associated with brachytherapy treatment.

  1. Head teacher professional networks in Italy: preliminary results of a national survey

    Directory of Open Access Journals (Sweden)

    Maurissens Isabel de

    2016-06-01

    Full Text Available In this article, we present the preliminary results of a national survey conducted by INDIRE on head teachers communities and professional networks. About one-fourth of the total population of Italian public school leaders participated in the survey. One of the main intents of this research is to contribute to understanding of the phenomenon of professional networks frequented by school leaders and to pave the way for a further reflection on how to use such networks for head teachers’ training so as to support their daily professional practice conducted too often in isolation.

  2. Preliminary Results From the C-Pulse? OPTIONS HF European Multicenter Post-Market Study

    OpenAIRE

    Schulz, Antonia; Krabatsch, Thomas; Schmitto, Jan D.; Hetzer, Roland; Seidel, Mirko; Dohmen, Pascal M.; Hotz, Holger

    2016-01-01

    Background The C-Pulse? System is an extra-aortic balloon counterpulsation device. It is used to treat patients with heart failure disease in NYHA functional class III or ambulatory class IV. Material/Methods We present preliminary site-reported 6-month data from 3 centers in Germany as part of the prospective observational post-market OPTIONS HF study. Results Between May 2013 and March 2014, the C-Pulse System was implanted in 8 patients (7 male) with a mean age of 61.6?9.3 years. Four had ...

  3. Preliminary Results from Small-Pixel CdZnTe and CdTe Arrays

    Science.gov (United States)

    Ramsey, B. D.; Sharma, D. P.; Meisner, J.; Austin, R. A.

    1999-01-01

    We have evaluated 2 small-pixel (0.75 mm) Cadmium-Zinc-Telluride arrays, and one Cadmium-Telluride array, all fabricated for MSFC by Metorex (Finland) and Baltic Science Institute (Riga, Latvia). Each array was optimized for operating temperature and collection bias. It was then exposed to Cadmium-109 and Iron-55 laboratory isotopes, to measure the energy resolution for each pixel and was then scanned with a finely-collimated x-ray beam, of width 50 micron, to examine pixel to pixel and inter-pixel charge collections efficiency. Preliminary results from these array tests will be presented.

  4. Design and preliminary results of a fuel flexible industrial gas turbine combustor

    Science.gov (United States)

    Novick, A. S.; Troth, D. L.; Yacobucci, H. G.

    1981-01-01

    The design characteristics are presented of a fuel tolerant variable geometry staged air combustor using regenerative/convective cooling. The rich/quench/lean variable geometry combustor is designed to achieve low NO(x) emission from fuels containing fuel bound nitrogen. The physical size of the combustor was calculated for a can-annular combustion system with associated operating conditions for the Allison 570-K engine. Preliminary test results indicate that the concept has the potential to meet emission requirements at maximum continuous power operation. However, airflow sealing and improved fuel/air mixing are necessary to meet Department of Energy program goals.

  5. A combination of preliminary results on gauge boson couplings measured by the LEP Experiments

    CERN Document Server

    CERN. Geneva

    2004-01-01

    This note presents a combination of published and preliminary measurements of triple gauge boson couplings (TGCs) and quartic gauge boson couplings (QGCs) from the four LEP experiments. We give an updated combination of the charged TGCs, g1z, kg and lg in single and multi-parameter fits. Updated results from the QGCs from the ZZgg vertex, ac/Lambda^2 and a0/Lambda^2, are given as well. The combinations of neutral TGCs hiv anf fiv are also presented, including an updated fiv combination.

  6. Preliminary Results on the Experimental Investigation of the Structure Functions of Bound Nucleons

    Energy Technology Data Exchange (ETDEWEB)

    Bodek, Arie [Univ. of Rochester, NY (United States); Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2016-08-01

    We present preliminary results on an experimental study of the nuclear modification of the longitudinal ($\\sigma_L$) and transverse ($\\sigma_T$) structure functions of nucleons bound in nuclear targets. The origin of these modifications (commonly referred as as the EMC effect) is not fully understood. Our measurements of R= $\\sigma_L / \\sigma_T$ for nuclei ($R_A$) and for deuterium ($R_D$) indicate that nuclear modifications of the structure functions of bound nucleons are different for the longitudinal and transverse structure functions, and that contrary to expectation from several theoretical models, $R_A< R_D$.

  7. Brachytherapy in the treatment of skin cancer: an overview.

    Science.gov (United States)

    Skowronek, Janusz

    2015-10-01

    The incidence of skin cancer worldwide is constantly growing and it is the most frequently diagnosed tumor. Brachytherapy (BT) in particular localizations is a valuable tool of the exact radiation depot inside the tumor mass. In localizations such as the face, skull skin and inoperable tumors, relapses after surgery, radiotherapy are usually not suitable for primary or secondary invasive treatment. Brachytherapy is a safe procedure for organs at risk according to rapid fall of a dose outside the axis of the applicator with satisfactory dose localization inside the target. The complications rate is acceptable and treatment costs are low. In some tumors (great skin lesions in the scalp, near eyes or on the nose) BT allows for a great dose reduction in surrounding healthy tissues. Brachytherapy provides minimal dose delivery to surrounding healthy tissue, thus enabling good functional and cosmetic results. Treatment is possible almost in all cases on an outpatient basis.

  8. Quaternary sedimentation and active faulting along the Ecuadorian shelf: preliminary results of the ATACAMES Cruise (2012)

    Science.gov (United States)

    Michaud, F.; Proust, J. N.; Collot, J. Y.; Lebrun, J. F.; Witt, C.; Ratzov, G.; Pouderoux, H.; Martillo, C.; Hernández, M. J.; Loayza, G.; Penafiel, L.; Schenini, L.; Dano, A.; Gonzalez, M.; Barba, D.; De Min, L.; Ponce, G.; Urresta, A.; Calderon, M.

    2015-03-01

    Selected high-resolution seismic-reflection profiles and multibeam bathymetry acquired along the convergent Ecuador margin during the ATACAMES cruise on onboard the R/V L'Atalante (Jan.15-Feb.18, 2012) allow a preliminary evaluation of the neotectonic development and stratigraphic evolution of the margin based on the sismo-stratigraphic analysis of Quaternary sediment preserved on the margin shelf and upper slope. We present three major preliminary results. (1) The evolution of the Esmeraldas, Guayaquil and Santa Elena canyons. The head of the Esmeraldas canyon is the location of a continuous significant sediment transport. The Guayaquil canyon shows several episodes of deposition and incision. Aggrading sedimentation pattern in the canyon records several changes in relative sea-level. The subsidence of the Gulf of Guayaquil probably contributes to the good preservation of the canyon filling stages. The Santa Elena canyon is controlled by a SW-NE trending normal fault. (2) Variations of sediment accumulation and relative vertical motions are shown along-strike the shelf edge. Offshore the uplifted Manta peninsula, a pronounced subsidence of the shelf edge is documented by sedimentary clinoforms that have deposited in a morphological reentrant, and have migrated upslope testifying of a local subsidence meanwhile the adjacent La Plata Island area underwent uplift. In the Esmeraldas canyon area, a local uplift of the shelf is documented. (3) Two neotectonic fault systems with a possible transcurrent component are imaged across the shelf edge and upper margin slope offshore Jama, and Cape Galera. This possible transcurrent motion could be related to the reactivation of ancient faults of the upper plate by the subduction. These preliminary results indicate that the ATACAMES data set has a strong potential to evaluate the spatial and temporal contribution of tectonic and climate changes on the structural development and stratigraphic evolution of the Ecuador continental

  9. Developing a Verification and Training Phantom for Gynecological Brachytherapy System

    Directory of Open Access Journals (Sweden)

    Mahbobeh Nazarnejad

    2012-03-01

    Full Text Available Introduction Dosimetric accuracy is a major issue in the quality assurance (QA program for treatment planning systems (TPS. An important contribution to this process has been a proper dosimetry method to guarantee the accuracy of delivered dose to the tumor. In brachytherapy (BT of gynecological (Gyn cancer it is usual to insert a combination of tandem and ovoid applicators with a complicated geometry which makes their dosimetry verification difficult and important. Therefore, evaluation and verification of dose distribution is necessary for accurate dose delivery to the patients. Materials and Methods The solid phantom was made from Perspex slabs as a tool for intracavitary brachytherapy dosimetric QA. Film dosimetry (EDR2 was done for a combination of ovoid and tandem applicators introduced by Flexitron brachytherapy system. Treatment planning was also done with Flexiplan 3D-TPS to irradiate films sandwiched between phantom slabs. Isodose curves obtained from treatment planning system and the films were compared with each other in 2D and 3D manners. Results The brachytherapy solid phantom was constructed with slabs. It was possible to insert tandems and ovoids loaded with radioactive source of Ir-192 subsequently. Relative error was 3-8.6% and average relative error was 5.08% in comparison with the films and TPS isodose curves. Conclusion Our results showed that the difference between TPS and the measurements is well within the acceptable boundaries and below the action level according to AAPM TG.45. Our findings showed that this phantom after minor corrections can be used as a method of choice for inter-comparison analysis of TPS and to fill the existing gap for accurate QA program in intracavitary brachytherapy. The constructed phantom also showed that it can be a valuable tool for verification of accurate dose delivery to the patients as well as training for brachytherapy residents and physics students.

  10. Validation of GPUMCD for low-energy brachytherapy seed dosimetry

    Energy Technology Data Exchange (ETDEWEB)

    Hissoiny, Sami; Ozell, Benoit; Despres, Philippe; Carrier, Jean-Francois [Ecole polytechnique de Montreal, Departement de genie informatique et genie logiciel, 2500 chemin de Polytechnique, Montreal, QC, H3T 1J4 (Canada); Departement de radio-oncologie, Centre hospitalier universitaire de Quebec (CHUQ), 11 Cote du Palais, Quebec, QC, G1R 2J6 (Canada); Departement de physique, Universite de Montreal, Montreal, QC (Canada) and Departement de radio-oncologie and Centre de recherche du CHUM, Centre hospitalier de l' Universite de Montreal (CHUM), Montreal, QC, H2L 4M1 (Canada)

    2011-07-15

    Purpose: To validate GPUMCD, a new package for fast Monte Carlo dose calculations based on the GPU (graphics processing unit), as a tool for low-energy single seed brachytherapy dosimetry for specific seed models. As the currently accepted method of dose calculation in low-energy brachytherapy computations relies on severe approximations, a Monte Carlo based approach would result in more accurate dose calculations, taking in to consideration the patient anatomy as well as interseed attenuation. The first step is to evaluate the capability of GPUMCD to reproduce low-energy, single source, brachytherapy calculations which could ultimately result in fast and accurate, Monte Carlo based, brachytherapy dose calculations for routine planning. Methods: A mixed geometry engine was integrated to GPUMCD capable of handling parametric as well as voxelized geometries. In order to evaluate GPUMCD for brachytherapy calculations, several dosimetry parameters were computed and compared to values found in the literature. These parameters, defined by the AAPM Task-Group No. 43, are the radial dose function, the 2D anisotropy function, and the dose rate constant. These three parameters were computed for two different brachytherapy sources: the Amersham OncoSeed 6711 and the Imagyn IsoStar IS-12501. Results: GPUMCD was shown to yield dosimetric parameters similar to those found in the literature. It reproduces radial dose functions to within 1.25% for both sources in the 0.5< r <10 cm range. The 2D anisotropy function was found to be within 3% at r = 5 cm and within 4% at r = 1 cm. The dose rate constants obtained were within the range of other values reported in the literature.Conclusion: GPUMCD was shown to be able to reproduce various TG-43 parameters for two different low-energy brachytherapy sources found in the literature. The next step is to test GPUMCD as a fast clinical Monte Carlo brachytherapy dose calculations with multiple seeds and patient geometry, potentially providing

  11. Preliminary results in large bone segmentation from 3D freehand ultrasound

    Science.gov (United States)

    Fanti, Zian; Torres, Fabian; Arámbula Cosío, Fernando

    2013-11-01

    Computer Assisted Orthopedic Surgery (CAOS) requires a correct registration between the patient in the operating room and the virtual models representing the patient in the computer. In order to increase the precision and accuracy of the registration a set of new techniques that eliminated the need to use fiducial markers have been developed. The majority of these newly developed registration systems are based on costly intraoperative imaging systems like Computed Tomography (CT scan) or Magnetic resonance imaging (MRI). An alternative to these methods is the use of an Ultrasound (US) imaging system for the implementation of a more cost efficient intraoperative registration solution. In order to develop the registration solution with the US imaging system, the bone surface is segmented in both preoperative and intraoperative images, and the registration is done using the acquire surface. In this paper, we present the a preliminary results of a new approach to segment bone surface from ultrasound volumes acquired by means 3D freehand ultrasound. The method is based on the enhancement of the voxels that belongs to surface and its posterior segmentation. The enhancement process is based on the information provided by eigenanalisis of the multiscale 3D Hessian matrix. The preliminary results shows that from the enhance volume the final bone surfaces can be extracted using a singular value thresholding.

  12. Using VIIRS Day/Night Band to Measure Electricity Supply Reliability: Preliminary Results from Maharashtra, India

    Directory of Open Access Journals (Sweden)

    Michael L. Mann

    2016-08-01

    Full Text Available Unreliable electricity supplies are common in developing countries and impose large socio-economic costs, yet precise information on electricity reliability is typically unavailable. This paper presents preliminary results from a machine-learning approach for using satellite imagery of nighttime lights to develop estimates of electricity reliability for western India at a finer spatial scale. We use data from the Visible Infrared Imaging Radiometer Suite (VIIRS onboard the Suomi National Polar Partnership (SNPP satellite together with newly-available data from networked household voltage meters. Our results point to the possibilities of this approach as well as areas for refinement. With currently available training data, we find a limited ability to detect individual outages identified by household-level measurements of electricity voltage. This is likely due to the relatively small number of individual outages observed in our preliminary data. However, we find that the approach can estimate electricity reliability rates for individual locations fairly well, with the predicted versus actual regression yielding an R2 > 0.5. We also find that, despite the after midnight overpass time of the SNPP satellite, the reliability estimates derived are representative of daytime reliability.

  13. DETECTION OF Helicobacter pylori IN GASTRIC MUCOSA OF SHEEP: PRELIMINARY RESULTS

    Directory of Open Access Journals (Sweden)

    A. Rella

    2013-02-01

    Full Text Available Helicobacter pylori is an organism widespread in humans and sometimes responsible for serious illnesses. It has been hypothesized the existence of animal reservoirs, and that the infection route by H. pylori involves multiple pathways including food-borne transmission as the microorganism has been detected from sheep, goat and cow milk. This work reports the preliminary results of a survey conducted in order to investigate the presence of H. pylori in gastric mucosa of sheep slaughtered in Apulia region (Italy employing a Nested Polymerase Chain Reaction (Nested-PCR assay for the detection of the phosphoglucosamine mutase gene (glmM, as screening method followed by conventional bacteriological isolation. Out of the 50 gastric mucosa samples examined, 3 (6% resulted positive for the presence of glmMgene, but at this time no strains were isolated. The results deserve further investigations to asses the role of ruminants as possible reservoirs of H. pylori.

  14. [Perioperative interstitial brachytherapy for recurrent keloid scars].

    Science.gov (United States)

    Rio, E; Bardet, E; Peuvrel, P; Martinet, L; Perrot, P; Baraer, F; Loirat, Y; Sartre, J-Y; Malard, O; Ferron, C; Dreno, B

    2010-01-01

    Evaluation of the results of perioperative interstitial brachytherapy with low dose-rate (LDR) Ir-192 in the treatment of keloid scars. We performed a retrospective analysis of 73 histologically confirmed keloids (from 58 patients) resistant to medicosurgical treated by surgical excision plus early perioperative brachytherapy. All lesions were initially symptomatic. Local control was evaluated by clinical evaluation. Functional and cosmetic results were assessed in terms of patient responses to a self-administered questionnaire. Median age was 28 years (range 13-71 years). Scars were located as follows: 37% on the face, 32% on the trunk or abdomen, 16% on the neck, and 15% on the arms or legs. The mean delay before loading was four hours (range, 1-6h). The median dose was 20Gy (range, 15-40Gy). Sixty-four scars (from 53 patients) were evaluated. Local control was 86% (follow-up, 44.5 months; range, 14-150 months). All relapses occurred early - within 2 years posttreatment. At 20 months, survival without recurrence was significantly lower when treated lengths were more than 6cm long. The rate was 100% for treated scars below 4.5cm in length, 95% (95% CI: 55-96) for those 4.5-6cm long, and 75% (95% CI: 56-88) beyond 6cm (p=0.038). Of the 35 scars (28 patients) whose results were reassessed, six remained symptomatic and the esthetic results were considered to be good in 51% (18/35) and average in 37% (13/35) (median follow-up, 70 months; range, 16-181 months). Early perioperative LDR brachytherapy delivering 20Gy at 5mm reduced the rate of recurrent keloids resistant to other treatments and gave good functional results. 2009 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.

  15. Preliminary assessment of the Long Island National Wildlife Refuge Complex Environmental contaminants background survey: Second year results

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report represents the preliminary results of the second year of the multiyear study, The Long Island National Wildlife Refuge Complex (Complex) Environmental...

  16. Preliminary assessment of the Long Island National Wildlife Refuge Complex environmental contaminants background study: Fifth year results

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report represents the preliminary results of the fifth year of the multiyear study entitled, "The Long Island National Wildlife Refuge Complex (Complex)...

  17. An Elizabethan Survey and Possible Astronomical Observations on the Oregon Coast: Preliminary Results

    Science.gov (United States)

    Haramundanis, Katherine; Gaposchkin, E.

    2007-12-01

    We present preliminary results of our investigations of inscribed rocks found along the Oregon Coast. The roughly 30 rocks contain Latin letters, numbers, and other signs. Bawlf (2000), after Costaggini and Schultz (1977), suggested that the artifacts represent a survey and longitude observation made by Francis Drake in 1579 during his circumnavigation. We have analyzed old records and photographs, and made preliminary site visits to evaluate if these suggestions have merit. The artifacts were first seen in the late 19th century by settlers along the Nehalem River and inspired early searches for treasure on the mountainside, which is rugged, rocky, and steep. The nearby wreck of a Spanish galleon confounded the interpretations. The director of the local Tillamook County Pioneer Museum, Wayne Jensen, with an enthusiastic colleague, Don Viles, spent two decades looking for artifacts and commissioned the existing site survey from the Civil Engineering Department of Oregon State University. Both Viles (1982, 1990) and Jensen (1990) published descriptions of the finds and their search methods. We present photographs of several of the larger artifacts, our conclusions about what the site represents and who may have created it, and suggestions about the meaning of some of the markings and artifacts, including calculations for possible astronomical observations. We solicit comments from the audience regarding any similar sites.

  18. A color spectrographic phonocardiography (CSP applied to the detection and characterization of heart murmurs: preliminary results

    Directory of Open Access Journals (Sweden)

    Hassani Kamran

    2011-05-01

    Full Text Available Abstract Background Although cardiac auscultation remains important to detect abnormal sounds and murmurs indicative of cardiac pathology, the application of electronic methods remains seldom used in everyday clinical practice. In this report we provide preliminary data showing how the phonocardiogram can be analyzed using color spectrographic techniques and discuss how such information may be of future value for noninvasive cardiac monitoring. Methods We digitally recorded the phonocardiogram using a high-speed USB interface and the program Gold Wave http://www.goldwave.com in 55 infants and adults with cardiac structural disease as well as from normal individuals and individuals with innocent murmurs. Color spectrographic analysis of the signal was performed using Spectrogram (Version 16 as a well as custom MATLAB code. Results Our preliminary data is presented as a series of seven cases. Conclusions We expect the application of spectrographic techniques to phonocardiography to grow substantially as ongoing research demonstrates its utility in various clinical settings. Our evaluation of a simple, low-cost phonocardiographic recording and analysis system to assist in determining the characteristic features of heart murmurs shows promise in helping distinguish innocent systolic murmurs from pathological murmurs in children and is expected to useful in other clinical settings as well.

  19. Interstitial brachytherapy for carcinoma of the base of tongue using a high dose rate {sup 192}Ir remote afterloader

    Energy Technology Data Exchange (ETDEWEB)

    Nishimura, Tetsuo; Imai, Michiko; Iijima, Mitsuharu; Suzuki, Kazunori; Nozue, Masashi; Kaneko, Masao; Mukodaka, Hiroyuki; Asai, Yoshihiro [Hamamatsu Univ., Shizuoka (Japan). School of Medicine

    1996-11-01

    We have applied an interstitial brachytherapy employing a high dose rate {sup 192}Ir remote afterloader to five patients with cancer of the base of tongue since December 1994. Insertion of applicators was carried out with tracheotomy under general anesthesia. Brachytherapy was delivered twice a day with a 6-hour interval. Irradiation dose was estimated at the point of 5 mm from outer applicators. HDR brachytherapy was well tolerated for 4-5 days in all patients and acute radiation reaction was minimal. Local control were observed in two cases. In conclusion, our preliminary experience suggests that HDR brachytherapy may be an option in the radiotherapy for carcinoma of the base of tongue. Optimal dose-fractionation protocol should be established. (author)

  20. Plant exploitation during the early Natufian in north-eastern Jordan: preliminary results from Shubayqa 1

    DEFF Research Database (Denmark)

    Otaegui, Amaia Arranz; Richter, Tobias

    on this time period is the low density of plant remains preserved in archaeological sites. This largely contrasts with the extraordinary well-preserved archaeobotanical assemblage found at the Early and Late Natufian Shubayqa 1. In this paper, we present the preliminary results of wood charcoal and non-woody......In spite of southwest Asia being one of the areas in the world where archaeobotanists have worked longest, information regarding plant exploitation during the Natufian period is still patchy and more materials and well-sampled sites are needed. One of the problems faced by archaeobotanists working...... plant analyses from two in situ hearth structures, along with a summary of the available evidence at other contemporary early Natufian sites. In terms of past vegetation, the results show the presence of wetland species indicating a more forested and wet environment during the early Natufian, which...

  1. Hybrid Spectral Micro-CT: System Design, Implementation, and Preliminary Results

    CERN Document Server

    Bennett, James R; Xu, Qiong; Yu, Hengyong; Walsh, Michael; Butler, Anthony; Butler, Phillip; Cao, Guohua; Mohs, Aaron; Wang, Ge

    2014-01-01

    Spectral CT has proven an important development in biomedical imaging, and there have been several publications in the past years demonstrating its merits in pre-clinical and clinical applications. In 2012, Xu et al. reported that near-term implementation of spectral micro-CT could be enhanced by a hybrid architecture: a narrow-beam spectral "interior" imaging chain integrated with a traditional wide-beam "global" imaging chain. This hybrid integration coupled with compressive sensing (CS)-based interior tomography demonstrated promising results for improved contrast resolution, and decreased system cost and radiation dose. The motivation for the current study is implementation and evaluation of the hybrid architecture with a first-of-its-kind hybrid spectral micro-CT system. Preliminary results confirm improvements in both contrast and spatial resolution. This technology is shown to merit further investigation and potential application in future spectral CT scanner design.

  2. Measurement of pressure ridges in SAR images of sea ice - Preliminary results on scattering theory

    Science.gov (United States)

    Vesecky, J. F.; Smith, M. P.; Daida, J. M.; Samadani, R.; Camiso, J. C.

    1992-01-01

    Sea ice ridges and keels (hummocks and bummocks) are important in sea ice research for both scientific and practical reasons. A long-term objective is to make quantitative measurements of sea ice ridges using synthetic aperture radar (SAR) images. The preliminary results of a scattering model for sea ice ridge are reported. The approach is through the ridge height variance spectrum Psi(K), where K is the spatial wavenumber, and the two-scale scattering model. The height spectrum model is constructed to mimic height statistics observed with an airborne optical laser. The spectrum model is used to drive a two-scale scattering model. Model results for ridges observed at C- and X-band yield normalized radar cross sections that are 10 to 15 dB larger than the observed cross sections of multiyear ice over the range of angles of incidence from 10 to 70 deg.

  3. Surface faulting during the August 24, 2016, central Italy earthquake (Mw 6.0: preliminary results

    Directory of Open Access Journals (Sweden)

    Franz A. Livio

    2016-11-01

    Full Text Available We present some preliminary results on the mapping of coseismically-induced ground ruptures following the Aug. 24, 2016, Central Italy earthquake (Mw 6.0. The seismogenic source, as highlighted by InSAR and seismological data, ruptured across two adjacent structures: the Vettore and Laga faults. We collected field data on ground breaks along the whole deformed area and two different scenarios of on-fault coseismic displacement arise from these observations. To the north, along the Vettore fault, surface faulting can be mapped quite continuously along a well-defined fault strand while such features are almost absent to the south, along the Laga fault, where flysch-like marly units are present. A major lithological control, affects the surface expression of faulting, resulting in a complex deformation pattern.

  4. Preliminary results of the large experimental wind turbine phase of the national wind energy program

    Science.gov (United States)

    Thomas, R. L.; Sholes, J. E.

    1975-01-01

    A major phase of the wind energy program is the development of reliable wind turbines for supplying cost-competitive electrical energy. This paper discusses the preliminary results of two projects in this phase of the program. First an experimental 100 kW wind turbine design and its status are reviewed. Also discussed are the results of two parallel design studies for determining the configurations and power levels for wind turbines with minimum energy costs. These studies show wind energy costs of 7 to 1.5 c/kWH for wind turbines produced in quantities of 100 to 1000 a year and located at sites having average winds of 12 to 18 mph.

  5. Experimental Investigation of the Vehicle-Ground Interaction - Experiment Preparation and Preliminary Results

    Science.gov (United States)

    Valašková, Veronika; Vlček, Jozef

    2017-12-01

    Interaction of the moving vehicle and the ground represents the actual engineering, environmental and economic problem. Due to the complexity of the problem, a combination of the experimental measurement and the computational simulation to understand the interaction mechanism is the most beneficial approach. Results of the in-situ observation serve as an input for the numerical analysis and also as a background for the calibration of the model. Presented paper brings the summary of the experiment preparation and preliminary results which are necessary for further analyses and numerical models. Computational simulations will be helpful for understanding the vehicle-ground interaction when inputs will be verified by the experimental way at known boundary conditions.

  6. Towards seasonal hydrological forecasting in mountain catchments: preliminary results from the APRIL project

    Science.gov (United States)

    Pistocchi, Alberto; Mazzoli, Paolo; Bagli, Stefano; Notarnicola, Claudia; Pasolli, Luca

    2013-04-01

    The APRIL project aims at addressing the long term quantitative prediction of monthly discharge from mountain catchments and setting up a system which can then be used operationally. More specifically, its objectives are: - To investigate the potential of EO products (snow cover extent, vegetation and soil moisture statust) and weather/climatic variables for the prediction of water streamflow from mountain catchments - To develop a robust methodology for the long term quantitative forecast of montly discharge from EO and weather/climatic data - To build a fully operational system for seasonal hydrological forecasting. This contribution illustrates the general concept of the project as well as some preliminary results. Water discharge in mountain catchments is physically related to antecedent snow cover and climatology (precipitation, temperature). Other factors may play a role, such as vegetation/soil status and topography. Historical discharge measurements and earth observation (EO) data are a valuable source for inferring the quantitative relationship between the discharge and its predictors using appropriate techniques. The prediction is based on the Support Vector Regression (SVR)technique, a state of the art machine learning regression method with good intrinsic generalization ability and robustness. In the contribution we present and discuss results of a preliminary analysis on water discharge prediction ( with lead time of 1 to 3 months) in South Tyrol, Italy. Despite the use of a limited set of predictors (among which mainly snow cover area), the results are encouraging. The analysis is in the process of being extended at different spatial scales, which will give the possibility to investigate different aspects of the problem and develop different prediction systems; by updating on the current developments, the contribution discusses also perspectives and current limitations towards the set up of a fully operational seasonal hydrological forecasting system

  7. Brachytherapy in oesophageal carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Leung, J.T.; Kuan, R. [Royal Prince Alfred Hospital, Camperdown, NSW (Australia)

    1995-11-01

    Patients with recurrent or locally advanced oesophageal carcinoma have a poor prognosis. Relief of dysphagia is often the goal of any further treatment. Several methods, including laser re-canalization, prosthetic intubation, dilatation, external beam irradiation (EBI) and intraluminal brachytherapy (IBT) can be used to alleviate dysphagia. In this retrospective review of 11 patients, eight with recurrent tumour and three newly diagnosed patients were treated with low dose rate IBT. Relief of dysphagia was achieved in nine patients, all of whom were able to maintain swallowing of at least a semi-solid diet until death or last follow-up. Toxicity was minimal, but survival was poor, with a median survival of only 3 months. IBT presents several advantages over other palliative methods, especially in recurrent tumours where re-treatment with EBI is often difficult because of normal tissue tolerance. Low dose rate IBT takes only 1-2 days to deliver, is highly effective, has little morbidity and the palliation achieved is relatively durable. 19 refs., 2 tabs., 1 fig.

  8. An approach to using conventional brachytherapy software for clinical treatment planning of complex, Monte Carlo-based brachytherapy dose distributions

    Energy Technology Data Exchange (ETDEWEB)

    Rivard, Mark J.; Melhus, Christopher S.; Granero, Domingo; Perez-Calatayud, Jose; Ballester, Facundo [Department of Radiation Oncology, Tufts University School of Medicine, Boston, Massachusetts 02111 (United States); Radiation Oncology Department, Physics Section, ' ' La Fe' ' University Hospital, Avenida Campanar 21, E-46009 Valencia (Spain); Department of Atomic, Molecular, and Nuclear Physics, University of Valencia, C/Dr. Moliner 50, E-46100 Burjassot, Spain and IFIC (University of Valencia-CSIC), C/Dr. Moliner 50, E-46100 Burjassot (Spain)

    2009-06-15

    dosimetry parameter data {<=}0.1 cm was required, and the virtual brachytherapy source data set included over 5000 data points. On the other hand, the lack of consideration for applicator heterogeneity effect caused conventional dose overestimates exceeding an order of magnitude in regions of clinical interest. This approach is rationalized by the improved dose estimates. In conclusion, a new technique was developed to incorporate complex Monte Carlo-based brachytherapy dose distributions into conventional TPS. These results are generalizable to other brachytherapy source types and other TPS.

  9. Spinal anaesthesia for brachytherapy for carcinoma of the cervix: a ...

    African Journals Online (AJOL)

    Setting and subjects: Forty female patients, presenting to Groote Schuur Hospital for brachytherapy for carcinoma of the cervix, were randomised to receive either 5 mg or 9 mg (1 ml or 1.8 ml) of 0.5% hyperbaric bupivacaine, plus 15 μg fentanyl via the L3/L4 interspace. Results: Patients receiving the lower dose could be ...

  10. THE BREED TRACEABILITY OF SHEEP MEAT BY USING MOLECULAR GENETICS METHODS: PRELIMINARY RESULTS

    Directory of Open Access Journals (Sweden)

    A. Bramante

    2011-04-01

    Full Text Available Safety and quality foods of animal origin are extremely important for consumers. The aim of this work was to evaluate the feasibility of a method to track the breed origin of sheep meat all along the production chain using molecular genetics tools. A total of 800 samples evenly distributed among seven Italian sheep breeds have been typed at 19 STR markers, together with 90 samples from both imported sheep animals and local crossbred animals withdrawn at slaughterhouses. A maximum likelihood assignment test was adopted to evaluate STR ability to allocate samples to their true breed of origin. Sarda animals were all correctly allocated, as well as more than 98% of samples from the other breeds. Only slightly worst allocation performances were observed for imported and crossbred animals. Preliminary results seem quite promising, though further analyses will be needed in order to better understand the statistical power of such an assignment test before implementation in the sheep meat production chain.

  11. Landslides Forecasting Analysis By Displacement Time Series Derived From Satellite INSAR Data: Preliminary Results

    Science.gov (United States)

    Mazzanti, P.; Rocca, A.; Bozzano, F.; Cossu, R.; Floris, M.

    2012-01-01

    In this paper preliminary results of the Cat-1 project ”Landslides forecasting analysis by displacement time series derived from Satellite and Terrestrial InSAR data” are presented. The project focuses on landslide forecasting analysis, based on the application of slope creep models. Displacements data through time, related to landslides strain evolution, are usually derived by classical monitoring methods. Here we propose the use of spaceborne synthetic aperture radar (SAR) differential interferometry (DInSAR) to achieve past displacements information of already collapsed landslides. Persistent Scatterers (PS) InSAR and Small Baseline Subset (SBAS) InSAR are considered and discussed in the perspective of proposed application. Furthermore, a rating method to evaluate the suitability of landslide prediction and investigation by Satellite InSAR technique is presented and tested over two case studies.

  12. Preliminary results from the prototype synchrotron radiation detector on space shuttle mission STS-108

    Energy Technology Data Exchange (ETDEWEB)

    Anderhub, H.; Bates, J.R.; Baetzner, D.; Baumgartner, S.; Biland, A. E-mail: biland@particle.phys.ethz.ch; Camps, C.; Capell, M.; Commichau, V.; Djambazov, L.; Fanchiang, Y.-J.; Fluegge, G.; Fritschi, M.; Grimm, O.; Hangarter, K.; Hofer, H.; Horisberger, U.; Kan, R.; Kaestli, W.; Kenney, G.P.; Kim, G.N.; Kim, K.S.; Koutsenko, V.; Kraeber, M.; Kuipers, J.; Lebedev, A.; Lee, M.W.; Lee, S.-C.; Lewis, R.; Lustermann, W.; Pauss, F.; Rauber, T.; Ren, D.; Ren, Z.L.; Roeser, U.; Son, D.; Ting, Samuel C.C.; Tiwari, A.N.; Viertel, G.M.; Gunten, H. von; Wicki, S. Waldmeier; Wang, T.-S.; Yang, J.; Zimmermann, B

    2002-12-01

    A Synchrotron Radiation Detector measures synchrotron radiation emitted by high energetic particles in the earth magnetic field. This allows to identify cosmic ray electrons and positrons with energies in the TeV region. One possibility for such a detector outside the atmosphere uses YAP crystals to measure synchrotron photons with energies in the keV range. As such a detector can not distinguish between photons and electrons, the main problems are the diffuse cosmic ray gamma background and low energetic electrons in the vicinity of the earth. While the intensity of the diffuse gamma rays is known quite well, there exists limited knowledge about keV-electrons in low earth orbits. To measure these electrons a Prototype Synchrotron Radiation Detector (PSRD) was flown with Space Shuttle mission STS-108 (Dec.2001) and preliminary analysis of the data show very favorable results.

  13. Acacia tortilis subsp. heteracantha productivity in the Tugela Dry Valley Bushveld: preliminary results

    Directory of Open Access Journals (Sweden)

    S. J. Milton

    1983-11-01

    Full Text Available Acacia tortilis Hayne subsp.  heteracantha (Burch. Brenan dominates secondary succession in the Tugela Dry Valley Bushveld of the Natal midlands. The parts of KwaZulu in this veld type are impoverished, overpopulated and over-grazed. Preliminary results indicate that at a density of 2 700 ± 600 trees/ha there is a standing crop of c.2,87 t/ha (DM of acacia twigs suitable for hand pruning and milling into fodder, but that this is a costly process. Herbage biomass peaked at 0,73 t/ha (DM. Veld condition assessments suggested a stocking rate of|0,l AU/ha (grazers, but actual grazer stocking rates may be many times this density. It is recommended that the browser/grazer ratio be altered to make use of the c. 1,05 t/ha (DM of shoot growth produced annually by A. tortilis subsp.  heteracantha.

  14. The design of a modular voluntary opening prosthetic hand: ongoing research and preliminary results.

    Science.gov (United States)

    El-Sheikh, Mogeeb A; Taher, Mona F

    2016-07-04

    This work presents the mechanical design of an artificial hand in order to address the need for a commercially feasible prosthetic hand. The hand has 3 compliant fingers and a thumb attached to a reconfigurable palm. The fingers and palm are a novel design, which is based on the natural arches of the hand. The design is modular, minimizing the number of parts and reducing assembly time. This hand and the expandable socket are designed for transradial amputees. It has 9 degrees of freedom (DOFs), 2 of them for the reconfigurable palm. The kinematics and adequate excursion for the fingers and palm are illustrated by finite element method (FEM). The study implements the mechanical parts by using rapid prototyping to assess preliminary results.

  15. Measurements of entanglement over a kilometric distance to test superluminal models of Quantum Mechanics: preliminary results.

    Science.gov (United States)

    Cocciaro, B.; Faetti, S.; Fronzoni, L.

    2017-08-01

    As shown in the EPR paper (Einstein, Podolsky e Rosen, 1935), Quantum Mechanics is a non-local Theory. The Bell theorem and the successive experiments ruled out the possibility of explaining quantum correlations using only local hidden variables models. Some authors suggested that quantum correlations could be due to superluminal communications that propagate isotropically with velocity vt > c in a preferred reference frame. For finite values of vt and in some special cases, Quantum Mechanics and superluminal models lead to different predictions. So far, no deviations from the predictions of Quantum Mechanics have been detected and only lower bounds for the superluminal velocities vt have been established. Here we describe a new experiment that increases the maximum detectable superluminal velocities and we give some preliminary results.

  16. Development and Preliminary Results of the Financial Incentive Coercion Assessment (FICA) Questionnaire

    Science.gov (United States)

    Byrne, Margaret M.; Croft, Jason R.; French, Michael T.; Dugosh, Karen L.; Festinger, David S.

    2013-01-01

    Financial incentives are often used in research, yet no measure exists to determine whether they lead to perceptions of coercion in subjects. We present a preliminary evaluation of a recently developed Financial Incentive Coercion Assessment (FICA) questionnaire. FICA measures perceived coercion specifically related to payment for participation in a research study. Two hundred and sixty-six subjects were recruited from a large randomized controlled trial; 152 returned for a six-month follow-up and completed the FICA. Approximately 30% of participants reported the major reason for participating was “for the money,” but less than 5% felt that the financial incentives were coercive. FICA results are consistent with levels of perceived coercion using an alternative measure. Initial assessment of responses on the FICA suggests that it may provide a novel approach to measuring perceived coercion from financial incentives in research. Future work will refine the FICA and analyze its psychometric properties. PMID:22116011

  17. Development and preliminary results of the Financial Incentive Coercion Assessment questionnaire.

    Science.gov (United States)

    Byrne, Margaret M; Croft, Jason R; French, Michael T; Dugosh, Karen L; Festinger, David S

    2012-07-01

    Financial incentives are often used in research, yet no measure exists to determine whether they lead to perceptions of coercion in subjects. We present a preliminary evaluation of a recently developed Financial Incentive Coercion Assessment (FICA) questionnaire. FICA measures perceived coercion specifically related to payment for participation in a research study. Two hundred sixty-six subjects were recruited from a large randomized controlled trial; 152 returned for a 6-month follow-up and completed the FICA. Approximately 30% of participants reported the major reason for participating was "for the money," but less than 5% felt that the financial incentives were coercive. FICA results are consistent with levels of perceived coercion using an alternative measure. Initial assessment of responses on the FICA suggests that it may provide a novel approach to measuring perceived coercion from financial incentives in research. Future work will refine the FICA and analyze its psychometric properties. Copyright © 2012. Published by Elsevier Inc.

  18. Fuzzy-logic-based hybrid locomotion mode classification for an active pelvis orthosis: Preliminary results.

    Science.gov (United States)

    Yuan, Kebin; Parri, Andrea; Yan, Tingfang; Wang, Long; Munih, Marko; Vitiello, Nicola; Wang, Qining

    2015-01-01

    In this paper, we present a fuzzy-logic-based hybrid locomotion mode classification method for an active pelvis orthosis. Locomotion information measured by the onboard hip joint angle sensors and the pressure insoles is used to classify five locomotion modes, including two static modes (sitting, standing still), and three dynamic modes (level-ground walking, ascending stairs, and descending stairs). The proposed method classifies these two kinds of modes first by monitoring the variation of the relative hip joint angle between the two legs within a specific period. Static states are then classified by the time-based absolute hip joint angle. As for dynamic modes, a fuzzy-logic based method is proposed for the classification. Preliminary experimental results with three able-bodied subjects achieve an off-line classification accuracy higher than 99.49%.

  19. Improving robotic stroke rehabilitation by incorporating neural intent detection: Preliminary results from a clinical trial.

    Science.gov (United States)

    Sullivan, Jennifer L; Bhagat, Nikunj A; Yozbatiran, Nuray; Paranjape, Ruta; Losey, Colin G; Grossman, Robert G; Contreras-Vidal, Jose L; Francisco, Gerard E; O'Malley, Marcia K

    2017-07-01

    This paper presents the preliminary findings of a multi-year clinical study evaluating the effectiveness of adding a brain-machine interface (BMI) to the MAHI-Exo II, a robotic upper limb exoskeleton, for elbow flexion/extension rehabilitation in chronic stroke survivors. The BMI was used to trigger robot motion when movement intention was detected from subjects' neural signals, thus requiring that subjects be mentally engaged during robotic therapy. The first six subjects to complete the program have shown improvements in both Fugl-Meyer Upper-Extremity scores as well as in kinematic movement quality measures that relate to movement planning, coordination, and control. These results are encouraging and suggest that increasing subject engagement during therapy through the addition of an intent-detecting BMI enhances the effectiveness of standard robotic rehabilitation.

  20. Instrumentation development for space debris optical observation system in Indonesia: Preliminary results

    Science.gov (United States)

    Dani, Tiar; Rachman, Abdul; Priyatikanto, Rhorom; Religia, Bahar

    2015-09-01

    An increasing number of space junk in orbit has raised their chances to fall in Indonesian region. So far, three debris of rocket bodies have been found in Bengkulu, Gorontalo and Lampung. LAPAN has successfully developed software for monitoring space debris that passes over Indonesia with an altitude below 200 km. To support the software-based system, the hardware-based system has been developed based on optical instruments. The system has been under development in early 2014 which consist of two systems: the telescopic system and wide field system. The telescopic system uses CCD cameras and a reflecting telescope with relatively high sensitivity. Wide field system uses DSLR cameras, binoculars and a combination of CCD with DSLR Lens. Methods and preliminary results of the systems will be presented.

  1. Cancer prevention interdisciplinary education program at Purdue University: overview and preliminary results.

    Science.gov (United States)

    Teegarden, Dorothy; Lee, Ji-Yeon; Adedokun, Omolola; Childress, Amy; Parker, Loran Carleton; Burgess, Wilella; Nagel, Julie; Knapp, Deborah W; Lelievre, Sophie; Agnew, Christopher R; Shields, Cleveland; Leary, James; Adams, Robin; Jensen, Jakob D

    2011-12-01

    Cancer prevention is a broad field that crosses many disciplines; therefore, educational efforts to enhance cancer prevention research focused on interdisciplinary approaches to the field are greatly needed. In order to hasten progress in cancer prevention research, the Cancer Prevention Internship Program (CPIP) at Purdue University was designed to develop and test an interdisciplinary curriculum for undergraduate and graduate students. The hypothesis was that course curriculum specific to introducing interdisciplinary concepts in cancer prevention would increase student interest in and ability to pursue advanced educational opportunities (e.g., graduate school, medical school). Preliminary results from the evaluation of the first year which included ten undergraduate and five graduate students suggested that participation in CPIP is a positive professional development experience, leading to a significant increase in understanding of interdisciplinary research in cancer prevention. In its first year, the CPIP project has created a successful model for interdisciplinary education in cancer prevention research.

  2. Description and preliminary results of a 100 square meter rain gauge

    Science.gov (United States)

    Grimaldi, Salvatore; Petroselli, Andrea; Baldini, Luca; Gorgucci, Eugenio

    2018-01-01

    Rainfall is one of the most crucial processes in hydrology, and the direct and indirect rainfall measurement methods are constantly being updated and improved. The standard instrument used to measure rainfall rate and accumulation is the rain gauge, which provides direct observations. Though the small dimension of the orifice allows rain gauges to be installed anywhere, it also causes errors due to the splash and wind effects. To investigate the role of the orifice dimension, this study, for the first time, introduces and demonstrates an apparatus for observing rainfall called a giant-rain gauge that is characterised by a collecting surface of 100 m2. To discuss the new instrument and its technical details, a preliminary analysis of 26 rainfall events is provided. The results suggest that there are significant differences between the standard and proposed rain gauges. Specifically, major discrepancies are evident for low time aggregation scale (5, 10, and 15 min) and for high rainfall intensity values.

  3. PRELIMINARY RESULTS OF ESTIMATING SOIL MOISTURE OVER BARE SOIL USING FULL-POLARIMETRIC ALOS-2 DATA

    Directory of Open Access Journals (Sweden)

    A. Sekertekin

    2016-10-01

    Full Text Available Synthetic Aperture Radar (SAR imaging system is one of the most effective way for Earth observation. The aim of this study is to present the preliminary results about estimating soil moisture using L-band Synthetic Aperture Radar (SAR data. Full-polarimetric (HH, HV, VV, VH ALOS-2 data, acquired on 22.04.2016 with the incidence angle of 30.4o, were used in the study. Simultaneously with the SAR acquisition, in-situ soil moisture samples over bare agricultural lands were collected and evaluated using gravimetric method. Backscattering coefficients for all polarizations were obtained and linear regression analysis was carried out with in situ moisture measurements. The best correlation coefficient was observed with VV polarization. Cross-polarized backscattering coefficients were not so sensitive to soil moisture content. In the study, it was observed that soil moisture maps can be retrieved with the accuracy about 14% (RMSE.

  4. Preliminary Results of Estimating Soil Moisture Over Bare Soil Using Full-Polarimetric ALOS-2 Data

    Science.gov (United States)

    Sekertekin, A.; Marangoz, A. M.; Abdikan, S.; Esetlili, M. T.

    2016-10-01

    Synthetic Aperture Radar (SAR) imaging system is one of the most effective way for Earth observation. The aim of this study is to present the preliminary results about estimating soil moisture using L-band Synthetic Aperture Radar (SAR) data. Full-polarimetric (HH, HV, VV, VH) ALOS-2 data, acquired on 22.04.2016 with the incidence angle of 30.4o, were used in the study. Simultaneously with the SAR acquisition, in-situ soil moisture samples over bare agricultural lands were collected and evaluated using gravimetric method. Backscattering coefficients for all polarizations were obtained and linear regression analysis was carried out with in situ moisture measurements. The best correlation coefficient was observed with VV polarization. Cross-polarized backscattering coefficients were not so sensitive to soil moisture content. In the study, it was observed that soil moisture maps can be retrieved with the accuracy about 14% (RMSE).

  5. Ayahuasca-assisted therapy for addiction: results from a preliminary observational study in Canada.

    Science.gov (United States)

    Thomas, Gerald; Lucas, Philippe; Capler, N Rielle; Tupper, Kenneth W; Martin, Gina

    2013-03-01

    This paper reports results from a preliminary observational study of ayahuasca-assisted treatment for problematic substance use and stress delivered in a rural First Nations community in British Columbia, Canada. The "Working with Addiction and Stress" retreats combined four days of group counselling with two expert-led ayahuasca ceremonies. This study collected pre-treatment and six months follow-up data from 12 participants on several psychological and behavioral factors related to problematic substance use, and qualitative data assessing the personal experiences of the participants six months after the retreat. Statistically significant (p ayahuasca-assisted therapy appears to be associated with statistically significant improvements in several factors related to problematic substance use among a rural aboriginal population. These findings suggest participants may have experienced positive psychological and behavioral changes in response to this therapeutic approach, and that more rigorous research of ayahuasca-assisted therapy for problematic substance use is warranted.

  6. Preliminary results on the suppression of sensing cross-talk in LISA Pathfinder

    Science.gov (United States)

    Wanner, Gudrun; Karnesis, Nikolaos; LISA Pathfinder Collaboration

    2017-05-01

    In the original paper describing the first measurements performed with LISA Pathfinder, a bulge in the acceleration noise was shown in the 200 mHz - 20 mHz frequency band. This bulge noise originated from cross-coupling of spacecraft motion into the longitudinal readout and it was shown that it is possible to subtract this cross-talk noise. We discuss here the model that was used for subtraction as well as an alternative approach to suppress the cross talk by realignment of the test masses. Such a realignment was performed after preliminary analysis of a dedicated cross-talk experiment, and we show the resulting noise suppression. Since then, further experiments have been performed to investigate the cross-coupling behaviour, however analysis of these experiments is still on-going.

  7. Preliminary Results from Simulations of Temperature Oscillations in Stirling Engine Regenerator Matrices

    DEFF Research Database (Denmark)

    Andersen, Stig Kildegård; Carlsen, Henrik; Thomsen, Per Grove

    2006-01-01

    . The model contains a system of ordinary differential equations (ODEs) derived from mass and energy balances for gas filled control volumes and energy balances for regenerator matrix control masses. Interpolation methods with filtering properties are used for state variables at control volume interfaces...... to reduce numerical diffusion and/or non-physical oscillations. Loss mechanisms are included directly in the governing equations as terms in the mass and energy balances. Steady state periodic solutions that satisfy cyclic boundary conditions and integral conditions are calculated using a custom built...... shooting method. It has been found possible to accurately solve the stiff ODE system that describes the coupled thermodynamics of the gas and the regenerator matrix and to reliably find periodic steady state solutions to the model. Preliminary results indicate that the regenerator matrix temperature...

  8. Triple endobuttton technique for the treatment of acute complete acromioclavicular joint dislocations: preliminary results.

    Science.gov (United States)

    Wei, Hai-Feng; Chen, Yun-Feng; Zeng, Bing-Fang; Zhang, Chang-Qing; Chai, Yi-Min; Wang, Hai-Ming; Lu, Ye

    2011-04-01

    Numerous procedures have been described for the operative management of acromioclavicular (AC) joint injuries. Some of these techniques, including hardware fixation and non-anatomical reconstructions, are associated with serious complications and high failure rates. Recently, AC joint reconstruction techniques have focused on anatomical restoration of the coracoclavicular ligaments to achieve optimal clinical outcomes. We used a triple endobutton technique to separately reconstruct the trapezoid and the coronoid portions of the coracoclavicular ligament. We evaluated the preliminary clinical and radiological results of this technique in patients with acute complete dislocation of the AC joint. All patients achieved a significant improvement in the pain and function of shoulder at a mean follow-up interval of 12 months (range, 8-14 months). Excellent reduction of the AC joint was maintained. The triple endobutton technique may be safe and effective for the treatment of acute complete AC joint dislocations.

  9. Raman scattering investigation of the water-bridge phenomenon: Some preliminary results

    Directory of Open Access Journals (Sweden)

    Francesco Aliotta

    2010-09-01

    Full Text Available A floating water-bridge is formed if a high-voltage direct current is applied between two beakers filled of chemically pure water. Raman spectra of the OH-stretching region have been obtained at ambient condition of temperature and pressure. These preliminary results seem to indicate that the hydrogen-bond structure is only slightly modified by the presence of the electric field applied to form the floating water-bridge in agreement with recent neutron scattering investigation. In fact, the polarized Raman spectrum of the pure water and of the water-bridge is almost superimposable. We are planning to carry out further spectroscopic analysis, at different thermodynamic conditions, for better understanding the role played by the hydrogen-bond in driving the formation of the floating water-bridge.

  10. Preliminary results obtained with the ZEUS phasing sensor within the APE experiment

    Science.gov (United States)

    Surdej, I.; Luong, B.; Vigan, A.; Araujo, C.; Bourtembourg, R.; Brast, R.; Duhoux, P.; Dupuy, C.; Frank, C.; Gonte, F.; Karban, R.; Mazzoleni, R.; Noethe, L.; Yaitskova, N.; Dohlen, K.

    2008-07-01

    In the framework of the Active Phasing Experiment (APE), four different phasing techniques are tested. The ZErnike Unit for Segment phasing sensor (ZEUS) is integrated on the APE bench. APE has been tested in the laboratory before it will be installed on one of the Nasmyth platform of a Very Large Telescope (VLT) Unit Telescope to perform on sky tests. The ZEUS phasing sensor concept has its origins in the Mach-Zehnder interferometer equipped with a spatial filter in its focal plane. In this paper, the ZEUS phasing sensor is described together with its theoretical background and deployment within the APE experiment. The algorithms and its elements used to reconstruct the wavefront are described. Finally, the preliminary results obtained in the laboratory are presented.

  11. Assessing soil-structure interaction during the 2016 central Italy seismic sequence (Italy: preliminary results

    Directory of Open Access Journals (Sweden)

    Arrigo Caserta

    2016-12-01

    Full Text Available We used the moderate-magnitude aftershocks succeeding to the 2016 August 24th, Mw = 6.0, Amatrice (Italy mainshok to asses, specially during an ongoing seismic sequence, the soil-structure interaction where cultural Heritage is involved. We have chosen as case study the San Giovanni Battista church (A.D. 1039  in Acquasanta Terme town, about 20 Km northeast of Amatrice. First of all we studied the soil shaking features in order to characterize the input to the monument. Then, using the recordings in the church, we tried to figure out  how the input seismic energy is distributed over the different monument parts. Some preliminary results are shown and discussed.

  12. Progresses in FAZIA detection system and preliminary results from the ISO-FAZIA experiment

    Science.gov (United States)

    Pastore, G.; Piantelli, S.; Gruyer, D.; Augey, L.; Barlini, S.; Bougault, R.; Bini, M.; Boiano, A.; Bonnet, E.; Borderie, B.; Bruno, M.; Casini, G.; Chbibi, A.; Cinausero, M.; Dell'Aquila, D.; Dueñas, J. A.; Fable, Q.; Fabris, D.; Francalanza, L.; Frankland, J. D.; Gramegna, F.; Henri, M.; Kordyasz, A.; Kozik, T.; La Torre, R.; Le Neindre, N.; Lombardo, I.; Lopez, L. O.; Mabiala, J.; Marchi, T.; Morelli, L.; Olmi, A.; Pârlog, M.; Pasquali, G.; Poggi, G.; Salomon, F.; Stefanini, A. A.; Valdrè, S.; Tortone, G.; Vient, E.; Verde, G.; Vigilante, M.; Alba, R.; Maiolino, , C.; Santonocito, D.

    2017-11-01

    In this contribution the status of the FAZIA project is presented, with a particular focus on the first experiment (identified as ISO-FAZIA) after the R&D phase. In this experiment four complete FAZIA blocks in a fully operating configuration were used. They were mounted in a planar "belt" geometry, symmetrically positioned with respect to the beam axis, covering the polar angles between 2.5° and 17.4° degrees. The investigated systems were 84Kr + 48, 40Ca at 35AMeV. The main goal of the experiment was the study of the isospin transport phenomena, extending a previous analysis. This contribution will report on the isotopic identification capability of the FAZIA detector as well as preliminary results concerning the average isospin of the quasi-projectile produced in semiperipheral collisions as a function of the isospin of the target.

  13. Microwave frequency sweep interferometer for plasma density measurements in ECR ion sources: Design and preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Torrisi, Giuseppe [INFN - Laboratori Nazionali del Sud, Via S. Sofia 62, 95125 Catania (Italy); University Mediterranea of Reggio Calabria, Reggio Calabria (Italy); Mascali, David; Neri, Lorenzo; Leonardi, Ornella; Celona, Luigi; Castro, Giuseppe; Agnello, Riccardo; Caruso, Antonio; Passarello, Santi; Longhitano, Alberto; Gammino, Santo [INFN - Laboratori Nazionali del Sud, Via S. Sofia 62, 95125 Catania (Italy); Sorbello, Gino [INFN - Laboratori Nazionali del Sud, Via S. Sofia 62, 95125 Catania (Italy); University of Catania, Catania, Italy and INFN-LNS, Catania (Italy); Isernia, Tommaso [University Mediterranea of Reggio Calabria, Reggio Calabria (Italy)

    2016-02-15

    The Electron Cyclotron Resonance Ion Sources (ECRISs) development is strictly related to the availability of new diagnostic tools, as the existing ones are not adequate to such compact machines and to their plasma characteristics. Microwave interferometry is a non-invasive method for plasma diagnostics and represents the best candidate for plasma density measurement in hostile environment. Interferometry in ECRISs is a challenging task mainly due to their compact size. The typical density of ECR plasmas is in the range 10{sup 11}–10{sup 13} cm{sup −3} and it needs a probing beam wavelength of the order of few centimetres, comparable to the chamber radius. The paper describes the design of a microwave interferometer developed at the LNS-INFN laboratories based on the so-called “frequency sweep” method to filter out the multipath contribution in the detected signals. The measurement technique and the preliminary results (calibration) obtained during the experimental tests will be presented.

  14. NEOLITHIC PLANT USE IN THE WESTERN MEDITERRANEAN REGION: PRELIMINARY RESULTS FROM THE AGRIWESTMED PROJECT

    Directory of Open Access Journals (Sweden)

    L. Peña-Chocarro

    2013-04-01

    Full Text Available This contribution focuses on the preliminary results of the AGRIWESTMED project which focuses on the archaeobotanical analyses of early Neolithic sites in the western Mediterranean region (both in Iberia and in northern Morocco. A large number of sites has been studied producing an interesting dataset of plant remains which places the earliest examples of domesticated plants in the second half of the 6th millennium cal BC. Plant diversity is high as it is shown by the large number of species represented: hulled and naked wheats, barley, peas, fava beans, vetches, lentils and grass peas. To more crops, poppy and flax, are also part of the first agricultural crops of the area. Although agriculture seems to occupy a first place in the production of food, gathering is well represented in the Moroccan sites where a large number of species has been identified. 

  15. Equity in transportation: new approach in transport planning – preliminary results of case study in Cracow

    Directory of Open Access Journals (Sweden)

    Lidia ZAKOWSKA

    2014-09-01

    Full Text Available The goal of the paper is to present the concept of equity as a new approach in transport and land-use planning. This concept is consistent with the objectives of sustainable development and it is becoming more common in European and world literature. Understanding the idea of equity in the context of the transport system development is very important in creating sustainable cities and regions without discriminating any social groups and creating a cohesive society not exposed to social exclusion due to lack of access to primary and secondary activities. The paper presents some results of the preliminary analysis on transport equity in Cracow. The basic equity level which has been considered here concerns senior citizens, older people living in Cracow area, in terms of their accessibility to transport infrastructure. Taking into account living conditions of elderly pedestrians, contour measures were used, in order to determine accessibility as equity indicator.

  16. High brachytherapy doses can counteract hypoxia in cervical cancer—a modelling study

    Science.gov (United States)

    Lindblom, Emely; Dasu, Alexandru; Beskow, Catharina; Toma-Dasu, Iuliana

    2017-01-01

    Tumour hypoxia is a well-known adverse factor for the outcome of radiotherapy. For cervical tumours in particular, several studies indicate large variability in tumour oxygenation. However, clinical evidence shows that the management of cervical cancer including brachytherapy leads to high rate of success. It was the purpose of this study to investigate whether the success of brachytherapy for cervical cancer, seemingly regardless of oxygenation status, could be explained by the characteristics of the brachytherapy dose distributions. To this end, a previously used in silico model of tumour oxygenation and radiation response was further developed to simulate the treatment of cervical cancer employing a combination of external beam radiotherapy and intracavitary brachytherapy. Using a clinically-derived brachytherapy dose distribution and assuming a homogeneous dose delivered by external radiotherapy, cell survival was assessed on voxel level by taking into account the variation of sensitivity with oxygenation as well as the effects of repair, repopulation and reoxygenation during treatment. Various scenarios were considered for the conformity of the brachytherapy dose distribution to the hypoxic region in the target. By using the clinically-prescribed brachytherapy dose distribution and varying the total dose delivered with external beam radiotherapy in 25 fractions, the resulting values of the dose for 50% tumour control, D 50, were in agreement with clinically-observed values for high cure rates if fast reoxygenation was assumed. The D 50 was furthermore similar for the different degrees of conformity of the brachytherapy dose distribution to the tumour, regardless of whether the hypoxic fraction was 10%, 25%, or 40%. To achieve 50% control with external RT only, a total dose of more than 70 Gy in 25 fractions would be required for all cases considered. It can thus be concluded that the high doses delivered in brachytherapy can counteract the increased

  17. Exercise and severe depression: preliminary results of an add-on study.

    Science.gov (United States)

    Schuch, F B; Vasconcelos-Moreno, M P; Borowsky, C; Fleck, M P

    2011-10-01

    Physical exercise has been extensively researched as a therapeutic option for treatment of major depression. In a randomized controlled trial, we analyze the effects of aerobic physical exercise as an add-on strategy for treatment of severe depressed inpatients. The exercise has a "Dose" of 16.5 kcal/kg/week, three times a week during all the hospitalization. Our preliminary results show that there is no significant difference in scores of Hamilton in the second week between groups (Mean[SD]=8.2[5.96] × 11.18[5.03], p=0.192). However, there is a significant reduction in Hamilton scores of patients in exercise group at discharge (Mean[SD]=5.93[4.46] × 9.45[3.56], p=0.041). Regarding Quality of Life (QoL), no significant difference were found between groups in the second week in physical domain (Mean[SD]=56.98[8.96] × 54.54[9.18], p=0.511) and psychological domain (Mean[SD]=50.88[13.88] × 42.04[12.42], p=0.106). However, there is a significant difference in psychological domain (Mean[SD]=55.88[9.92] v 41.66[13.04], p=0.004) and a trend but no statistical significance in the physical (Mean[SD]=58.80[9.14] × 52.12[8.70], p=0.07) at discharge. Many patients receive different treatment strategies, like ECT (1 patient at exercise group × 3 at control group). Other limitation is the small number of participants included until this moment. Our preliminary results suggest that physical exercise could be a feasible and effective add-on strategy for treatment of severe depressed inpatients, improving their depressive symptoms and QoL. Copyright © 2011 Elsevier B.V. All rights reserved.

  18. Multihelix rotating shield brachytherapy for cervical cancer

    Energy Technology Data Exchange (ETDEWEB)

    Dadkhah, Hossein [Department of Biomedical Engineering, University of Iowa, 1402 Seamans Center for the Engineering Arts and Sciences, Iowa City, Iowa 52242 (United States); Kim, Yusung; Flynn, Ryan T., E-mail: ryan-flynn@uiowa.edu [Department of Radiation Oncology, University of Iowa, 200 Hawkins Drive, Iowa City, Iowa 52242 (United States); Wu, Xiaodong [Department of Radiation Oncology, University of Iowa, 200 Hawkins Drive, Iowa City, Iowa 52242 and Department of Electrical and Computer Engineering, University of Iowa, 4016 Seamans Center for the Engineering Arts and Sciences, Iowa City, Iowa 52242 (United States)

    2015-11-15

    comparison. For all the generated treatment plans, the D{sub 90} of the HR-CTV in units of equivalent dose in 2 Gy fractions (EQD2) was escalated until the D{sub 2cc} (minimum dose to hottest 2 cm{sup 3}) tolerance of either the bladder (90 Gy{sub 3}), rectum (75 Gy{sub 3}), or sigmoid colon (75 Gy{sub 3}) was reached. Results: Treatment time changed for H-RSBT versus S-RSBT by −7.62% to 1.17% with an average change of −2.8%, thus H-RSBT treatments times tended to be shorter than for S-RSBT. The HR-CTV D{sub 90} also changed by −2.7% to 2.38% with an average of −0.65%. Conclusions: H-RSBT is a mechanically feasible delivery technique for use in the curved applicators needed for cervical cancer brachytherapy. S-RSBT and H-RSBT were clinically equivalent for all patients considered, with the H-RSBT technique tending to require less time for delivery.

  19. 77 FR 46687 - Polyethylene Terephthalate Film, Sheet, and Strip From India: Preliminary Results of Antidumping...

    Science.gov (United States)

    2012-08-06

    ... indirect selling expenses, including inventory carrying costs, incurred in the United States and India and... Preliminary Calculation Memorandum; see also Polyplex Preliminary Calculation Memorandum. Cost of Production Analysis For both Jindal and Polyplex, the Department disregarded sales below cost of production (COP) in...

  20. Brachytherapy dosimeter with silicon photomultipliers

    Energy Technology Data Exchange (ETDEWEB)

    Moutinho, L.M., E-mail: moutinho@ua.pt [i3N, Physics Department, University of Aveiro (Portugal); Castro, I.F.C. [i3N, Physics Department, University of Aveiro (Portugal); Peralta, L. [Faculdade de Ciências da Universidade de Lisboa (Portugal); Laboratório de Instrumentação e Física Experimental de Partículas (LIP), Lisboa (Portugal); Abreu, M.C. [Laboratório de Instrumentação e Física Experimental de Partículas (LIP), Lisboa (Portugal); Veloso, J.F.C.A. [i3N, Physics Department, University of Aveiro (Portugal)

    2015-07-01

    In-vivo and in-situ measurement of the radiation dose administered during brachytherapy faces several technical challenges, requiring a very compact, tissue-equivalent, linear and highly sensitive dosimeter, particularly in low-dose rate brachytherapy procedures, which use radioactive seeds with low energy and low dose deposition rate. In this work we present a scintillating optical fiber dosimeter composed of a flexible sensitive probe and a dedicated electronic readout system based on silicon photomultiplier photodetection, capable of operating both in pulse and current modes. The performance of the scintillating fiber optic dosimeter was evaluated in low energy regimes, using an X-ray tube operating at voltages of 40–50 kV and currents below 1 mA, to assess minimum dose response of the scintillating fiber. The dosimeter shows a linear response with dose and is capable of detecting mGy dose variations like an ionization chamber. Besides fulfilling all the requirements for a dosimeter in brachytherapy, the high sensitivity of this device makes it a suitable candidate for application in low-dose rate brachytherapy. According to Peralta and Rego [1], the BCF-10 and BCF-60 scintillating optical fibers used in dosimetry exhibit high variations in their sensitivity for photon beams in the 25–100 kVp energy range. Energy linearity for energies below 50 keV needs to be further investigated, using monochromatic X-ray photons.

  1. Interstitial HDR-brachytherapy of unresectable pancreatic carcinoma by 3D-CT-planning in combination with external beam radiation and chemotherapy, methodology and clinical results; 3D-CT-geplante interstitielle HDR-Brachytherapie + perkutane Bestrahlung und Chemotherapie bei inoperablen Pankreaskarzinomen. Methodik und klinische Ergebnisse

    Energy Technology Data Exchange (ETDEWEB)

    Pfreundner, L.; Baier, K.; Schwab, F.; Willner, J.; Bratengeier, K.; Flentje, M. [Wuerzburg Univ. (Germany). Klinik fuer Strahlentherapie; Feustel, H. [Chirurgische Abt. der Missionsaerztlichen Klinik, Wuerzburg (Germany); Fuchs, K.H. [Chirurgische Universitaetsklinik, Wuerzburg (Germany)

    1998-03-01

    Nineteen patients (9 female, 10 male, median age 67 years) with unresectable carcinoma of the pancreas have been treated with interstitial brachytherapy. Distribution according to UICC stages showed 4, 10 and 5 patients in stage II to IV respectively. In all cases afterloading technique with 192-iridium in HDR-modus was used. A total dose of 10 to 34 Gy to the reference isodose was delivered (single dose 1.88 to 5 Gy, median 2.5 Gy). Brachytherapy was followed by external radiotherapy, delivering an additional dose of 40 to 58 Gy. Nine patients received simultaneous chemotherapy (5-fluorouracil, leucovorin). Treatment planning was performed based on CT scans, allowing spatial correlation of isodose curves to the patient`s anatomy. Median survival time was 6 months. A trend of lower survival rates with advanced stage of disease (median survival stage IV 4 months, stage II and III 6.5 months) was seen. Local control rate was 70%. Brachytherapy treatment was well tolerated, severe acute side effects were not observed. One patient developed pancreatic fistulae 4 months and 1 patient a gastric ulcer 7 months after treatment. Pain release was achieved in all patients. (orig./MG) [Deutsch] 19 Patienten (neun Frauen, zehn Maenner) mit einem inoperablen Adenokarzinom des Pankreas (UICC-Stadium IV n=5, Stadium III n=10, Stadium II n=4) im Alter von median 67 Jahren wurden mit einer interstitiellen Brachytherapie mit 192-Iridium HDR im Afterloadingverfahren behandelt. Die auf die Referenzisodose eingestrahlten Dosen lagen zwischen 10 und 34 Gy, bei Einzeldosen von 1,88 bis 5 Gy (median 2,0 Gy). Der interstitiellen Therapie schloss sich eine perkutane Radiatio mit Gesamtdosen zwischen 40 und 58 Gy an. Bei neun Patienten wurde zusaetzlich eine Chemotherapie mit 5-Fluorouracil und Leucovorin appliziert. Fuer die interstitielle Brachytherapie wurde ein CT-gestuetztes Planungsverfahren angewandt, das eine raeumliche Zuordnung der Isodosenverteilung zur Patientenanatomie gestattet

  2. Trends in the Utilization of Adjuvant Vaginal Cuff Brachytherapy and/or External Beam Radiation Treatment in Stage I and II Endometrial Cancer: A Surveillance, Epidemiology, and End-Results Study

    Energy Technology Data Exchange (ETDEWEB)

    Patel, Mehul K. [Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan (United States); Cote, Michele L. [Karmanos Cancer Institute and Wayne State University, Detroit, Michigan (United States); Ali-Fehmi, Rouba [Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan (United States); Buekers, Thomas; Munkarah, Adnan R. [Department of Women' s Health Services, Division of Gynecologic Oncology, Henry Ford Health System, Detroit, Michigan (United States); Elshaikh, Mohamed A., E-mail: melshai1@hfhs.org [Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan (United States)

    2012-05-01

    Purpose: The optimal adjuvant radiation treatment for endometrial carcinoma (EC) remains controversial. Adjuvant vaginal cuff brachytherapy (VB) has emerged as an increasingly common treatment modality. However, the time trends for using VB, external beam radiation therapy (EBRT), or combined therapy (VB+EBRT) have not been well characterized. We therefore examined the utilization trends of VB, EBRT, and VB+EBRT for adjuvant RT in International Federation of Gynecologic Oncology (FIGO) stage I and II EC over time. Methods and Materials: We evaluated treatment patterns for 48,122 patients with EC diagnosed between January 1995 and December 2005, using the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) public use database. Chi-squared tests were used to assess differences by radiation type (VB, EBRT, and VB+EBRT) and various demographic and clinical variables. Results: Analyses were limited to 9,815 patients (20.4%) with EC who met the inclusion criteria. Among women who received adjuvant RT, the proportion receiving VB increased yearly (12.9% in 1995 compared to 32.8% in 2005 (p < 0.0001). The increasing use of VB was proportional to the decreasing use of EBRT (56.1% in 1995 to 45.8% in 2005; p < 0.0001) and VB+EBRT (31.0% in 1995 to 21.4% in 2005; p < 0.001). Conclusions: This population-based report demonstrates an increasing trend in the use of VB in the adjuvant setting after hysterectomy for treatment of women with FIGO stage I-II EC. VB alone appears to be replacing pelvic EBRT and VB+EBRT therapy in the management of stage I-II EC.

  3. Treatment of bulky stage IB and IIB cervical cancers with outpatient neutron brachytherapy, external pelvic radiation and extrafascial hysterectomy

    Energy Technology Data Exchange (ETDEWEB)

    Van Nagell, J.R.; Maruyama, Y.; Yoneda, J.; Donaldson, E.S.; Hanson, M.B.; Gallion, H.H.; Powell, D.E.; Kryscio, R.J.

    1986-01-01

    From January, 1977, to December, 1982, twenty-nine patients with bulky (>4 cms diameter) Stage IB or IIB cervical cancer were treated at the University of Kentucky Medical Center by a combination of out-patient neutron brachytherapy (Cf-252) and external pelvic radiation followed by extrafascial hysterectomy. Residual tumor was present in the hysterectomy specimens of 25 per cent. Complications during and following radiation therapy and surgery were minimal and included vaginal stenosis, proctitis, and hemorrhagic cystitis. The mean duration of hospitalization for surgery in these patients was 6.6 days (range 5-15 days) and postoperative morbidity was low. No patient required blood transfusion. Four patients developed urinary tract infections and two had superficial wound separations. Following treatment, patients were seen at monthly intervals for one year, every three months for two years, and every six months thereafter. No patient has been lost to follow-up. Two patients (7 per cent) developed tumor recurrence and have died of disease (1 of distant metastases; 1 local). The remaining 27 patients (93 per cent) are alive and well with no evidence of disease 24-89 months (mean 48 months) after therapy. No radiogenic fistulae or bowel obstruction were observed. These preliminary results suggest that the combination of outpatient neutron brachytherapy, external pelvic radiation, and extrafascial hysterectomy for patients with Stage IB and IIB cervical cancer is well tolerated. Complications associated with this treatment regimen have been minimal, and the recurrence rate is low. The duration of intracavitary neutron brachytherapy was short, and outpatient therapy was well received by patients.

  4. Intra-Operative Lymphatic Mapping and Sentinel Node Biopsy in Laryngeal Carcinoma: Preliminary Results

    Directory of Open Access Journals (Sweden)

    Ehsan Khadivi

    2015-07-01

    Full Text Available Introduction: Sentinel node mapping has been used for laryngeal carcinoma in several studies, with excellent results thus far.In the current study, we report our preliminary results on sentinel node mapping in laryngeal carcinoma using intra-operative peri-tumoral injection of a radiotracer.   Materials and Methods: Patients with biopsy-proven squamous cell carcinoma of the larynx were included in the study. Two mCi/0.4 cc Tc-99m-phytate in four aliquots was injected on the day of surgery, after induction of anesthesia, in the sub-mucosal peri-tumoral location using a suspension laryngoscopy. After waiting for 10 minutes, a portable gamma probe was used to search for sentinel nodes. All patients underwent laryngectomy and modified radical bilateral neck dissection. All sentinel nodes and removed non-sentinel nodes were examined by hematoxylin and eosin (H&E staining.   Results: Ten patients with laryngeal carcinoma were included. At least one sentinel node could be detected in five patients (bilateral nodes in four patients. One patient had pathologically involved sentinel and non-sentinel nodes (no false-negative cases.   Conclusion:  Sentinel node mapping in laryngeal carcinoma is technically feasible using an intra-operative radiotracer injection. In order to evaluate the relationship of T-stage and the laterality of the tumor with accuracy, larger studies are needed.

  5. New large solar photocatalytic plant: set-up and preliminary results.

    Science.gov (United States)

    Malato, S; Blanco, J; Vidal, A; Fernández, P; Cáceres, J; Trincado, P; Oliveira, J C; Vincent, M

    2002-04-01

    A European industrial consortium called SOLARDETOX has been created as the result of an EC-DGXII BRITE-EURAM-III-financed project on solar photocatalytic detoxification of water. The project objective was to develop a simple, efficient and commercially competitive water-treatment technology, based on compound parabolic collectors (CPCs) solar collectors and TiO2 photocatalysis, to make possible easy design and installation. The design, set-up and preliminary results of the main project deliverable, the first European industrial solar detoxification treatment plant, is presented. This plant has been designed for the batch treatment of 2 m3 of water with a 100 m2 collector-aperture area and aqueous aerated suspensions of polycrystalline TiO2 irradiated by sunlight. Fully automatic control reduces operation and maintenance manpower. Plant behaviour has been compared (using dichloroacetic acid and cyanide at 50 mg l(-1) initial concentration as model compounds) with the small CPC pilot plants installed at the Plataforma Solar de Almería several years ago. The first results with high-content cyanide (1 g l(-1)) waste water are presented and plant treatment capacity is calculated.

  6. Impulsivity in Multiplayer Online Battle Arena Gamers: Preliminary Results on Experimental and Self-Report Measures.

    Science.gov (United States)

    Nuyens, Filip; Deleuze, Jory; Maurage, Pierre; Griffiths, Mark D; Kuss, Daria J; Billieux, Joël

    2016-06-01

    Background and aims Multiplayer Online Battle Arena (MOBA) games have become the most popular type of video games played worldwide, superseding the playing of Massively Multiplayer Online Role-Playing Games and First-Person Shooter games. However, empirical studies focusing on the use and abuse of MOBA games are still very limited, particularly regarding impulsivity, which is an indicator of addictive states but has not yet been explored in MOBA games. In this context, the objective of the present study is to explore the associations between impulsivity and symptoms of addictive use of MOBA games in a sample of highly involved League of Legends (LoL, currently the most popular MOBA game) gamers. Methods Thirty-six LoL gamers were recruited and completed both experimental (Single Key Impulsivity Paradigm) and self-reported impulsivity assessments (s-UPPS-P Impulsive Behavior Scale, Barratt Impulsiveness Scale), in addition to an assessment of problematic video game use (Problematic Online Gaming Questionnaire). Results Results showed links between impulsivity-related constructs and signs of excessive MOBA game involvement. Findings indicated that impaired ability to postpone rewards in an experimental laboratory task was strongly related to problematic patterns of MOBA game involvement. Although less consistent, several associations were also found between self-reported impulsivity traits and signs of excessive MOBA game involvement. Conclusions Despite these results are preliminary and based upon a small (self-selected) sample, the present study highlights potential psychological factors related to the addictive use of MOBA games.

  7. The genetic variability of the Podolica cattle breed from the Gargano area. Preliminary results

    Directory of Open Access Journals (Sweden)

    Dario Cianci

    2010-01-01

    Full Text Available The Podolica cattle breed is autochthonous of Southern Italy and denoted by its particular rusticity. This study presents the preliminary results of the genetic characterization of the Podolica breed using DNA STR markers. A total of 20 microsatellite loci were analysed in 79 individuals reared in the Gargano area. Number of polymorphisms, allele fre- quencies, deviations from Hardy-Weinberg proportions, linkage disequilibrium between loci and genetic similarities between animals were calculated. The results showed a high deficiency of heterozygotes, the observed mean of het- erozygosis being 0.449, whereas the expected mean was 0.766. Many markers showed also deviations from the Hardy- Weinberg proportions and significant linkage disequilibrium between loci. However the genetic similarity within the pop- ulation was low (0.281 and the average number of alleles per locus was high (10, representing a high genetic vari- ability. In order to explain these results, a stratification of the breed in sub-populations with a high interior genetic homo- geneity but markedly differentiated one from each other could be hypothesized; this situation probably derived from non- random mating within each herd (consanguinity and from the lack of exchange of genetic material between the herds. A further study is needed on a wider sample and extending the analysis to FAO-ISAG microsatellite panel in order to con- firm this hypothesis. This could eventually provide the information necessary for the correct management of the repro- ductive schemes and for genomic traceability of meat production.

  8. New large solar photocatalytic plant: set-up and preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Malato, S.; Blanco, J.; Vidal, A.; Fernandez, P.; Caceres, J. [Plataforma Solar de Almeria (Spain); Trincado, P. [HIDROCEN, Madrid (Spain); Oliveira, J.C. [AOSOL, Samora-Corria (Portugal); Vincent, M. [ECOSYSTEM S.A., Barcelona (Spain)

    2002-04-01

    A European industrial consortium called SOLARDETOX has been created as the result of an EC-DGXII BRITE-EURAM-III-financed project on solar photocatalytic detoxification of water. The project objective was to develop a simple, efficient and commercially competitive water-treatment technology, based on compound parabolic collectors (CPCs) solar collectors and TiO{sub 2} photocatalysis, to make possible easy design and installation. The design, set-up and preliminary results of the main project deliverable, the first European industrial solar detoxification treatment plant, is presented. This plant has been designed for the batch treatment of 2 m{sup 3} of water with a 100 m{sup 2} collector-aperture area and aqueous aerated suspensions of polycrystalline TiO{sub 2} irradiated by sunlight. Fully automatic control reduces operation and maintenance manpower. Plant behaviour has been compared (using dichloroacetic acid and cyanide at 50 mgl{sup -1} initial concentration as model compounds) with the small CPC pilot plants installed at the Plataforma Solar de Almeria several years ago. The first results with high-content cyanide (1 gl{sup -1}) waste water are presented and plant treatment capacity is calculated. (author)

  9. Facial emotional recognition in schizophrenia: preliminary results of the virtual reality program for facial emotional recognition

    Directory of Open Access Journals (Sweden)

    Teresa Souto

    2013-01-01

    Full Text Available BACKGROUND: Significant deficits in emotional recognition and social perception characterize patients with schizophrenia and have direct negative impact both in inter-personal relationships and in social functioning. Virtual reality, as a methodological resource, might have a high potential for assessment and training skills in people suffering from mental illness. OBJECTIVES: To present preliminary results of a facial emotional recognition assessment designed for patients with schizophrenia, using 3D avatars and virtual reality. METHODS: Presentation of 3D avatars which reproduce images developed with the FaceGen® software and integrated in a three-dimensional virtual environment. Each avatar was presented to a group of 12 patients with schizophrenia and a reference group of 12 subjects without psychiatric pathology. RESULTS: The results show that the facial emotions of happiness and anger are better recognized by both groups and that the major difficulties arise in fear and disgust recognition. Frontal alpha electroencephalography variations were found during the presentation of anger and disgust stimuli among patients with schizophrenia. DISCUSSION: The developed program evaluation module can be of surplus value both for patient and therapist, providing the task execution in a non anxiogenic environment, however similar to the actual experience.

  10. Utilization and Outcomes of Breast Brachytherapy in Younger Women

    Science.gov (United States)

    Smith, Grace L; Huo, Jinhai; Giordano, Sharon H.; Hunt, Kelly K.; Buchholz, Thomas A; Smith, Benjamin D

    2015-01-01

    Background Breast brachytherapy after lumpectomy is controversial in younger patients, as effectiveness is unclear and selection criteria are debated. Methods Using MarketScan® healthcare claims data, we identified 45,884 invasive breast cancer patients (ages 18–64), treated from 2003–2010 with lumpectomy, followed by brachytherapy (n=3,134) or whole breast irradiation (WBI) (n=42,750). We stratified patients into risk groups, based on age (Agebrachytherapy vs. WBI patients, utilization trends and 5-year subsequent mastectomy risks were compared. Stratified, adjusted subsequent mastectomy risks were calculated using proportional hazards regression. Results Brachytherapy utilization increased from 2003 to 2010: In patients Agebrachytherapy patients were Agebrachytherapy patients were Endocrine- vs. 44% of WBI patients (P=0.003). Highest absolute 5-year subsequent mastectomy risks occurred in Endocrine−/Agebrachytherapy vs. 9.0% after WBI (Hazard ratio[HR]=2.18, 1.37–3.47); intermediate risks in Endocrine−/Age≥50 patients (8.6% vs. 4.9%; HR=1.76, 1.26–2.46); and lowest risks in Endocrine+ patients of any age: Endocrine+/Agebrachytherapy vs. WBI and therefore may be useful for selecting appropriate younger brachytherapy candidates. PMID:26279027

  11. Evaluation of resins for use in brachytherapy

    Energy Technology Data Exchange (ETDEWEB)

    Carvalho, Luiz Claudio F.M. Garcia; Ferraz, Wilmar Barbosa; Chrcanovic, Bruno Ramos; Santos, Ana Maria M., E-mail: ferrazw@cdtn.b, E-mail: amms@cdtn.b [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2011-07-01

    Brachytherapy is an advanced cancer treatment where radioactive seeds or sources are placed near or directly into the tumor thus reducing the radiation exposure in the surrounding healthy tissues. Prostate cancer can be treated with interstitial brachytherapy in initial stage of the disease in which tiny radioactive seeds with cylindrical geometry are used. Several kinds of seeds have been developed in order to obtain a better dose distribution around them and with a lower cost manufacturing. These seeds consist of an encapsulation, a radionuclide carrier, and X-ray marker. Among the materials that have potential for innovation in the construction of seeds, biocompatible resins appear as an important option. In this paper, we present some characterization results with Fourier transform infrared spectroscopic (FTIR) and ultraviolet-visible spectroscopy (UV-vis) performed on two types of resins in which curing temperatures for each one were varied as also the results of coatings with these resins under titanium substrates. Interactions of these resins in contact with the simulated body fluid were evaluated by atomic force microscopy, scanning electron microscopy, and energy dispersive X-ray spectroscopy. (author)

  12. A study of brachytherapy for intraocular tumor

    Energy Technology Data Exchange (ETDEWEB)

    Ji, Yung Hoon; Lee, Dong Han; Ko, Kyung Hwan; Lee, Tae Won; Lee, Sung Koo; Choi, Moon Sik [Korea Cancer Center Hospital of Korea Atomic Energy Research Institute, Seoul (Korea, Republic of)

    1994-12-01

    Our purpose of this study is to perform brachytherapy for intraocular tumor. The result were as followed. 1. Eye model was determined as a 25 mm diameter sphere. Ir-192 was considered the most appropriate as radioisotope for brachytherapy, because of the size, half, energy and availability. 2. Considering the biological response with human tissue and protection of exposed dose, we made the plaques with gold, of which size were 15 mm, 17 mm and 20 mm in diameter, and 1.5 mm in thickness. 3. Transmission factor of plaques are all 0.71 with TLD and film dosimetry at the surface of plaques and 0.45, 0.49 at 1.5 mm distance of surface, respectively. 4. As compared the measured data for the plaque with Ir-192 seeds to results of computer dose calculation model by Gary Luxton et al. and CAP-PLAN (Radiation Treatment Planning System), absorbed doses are within {+-}10% and distance deviations are within 0.4 mm. Maximum error is -11.3% and 0.8 mm, respectively. 7 figs, 2 tabs, 28 refs. (Author).

  13. MO-FG-BRA-01: Development of An Image-Guided Dosimetric Planning System for Injectable Brachytherapy Using ELP Nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Lafata, K [Duke University, Durham, North Carolina (United States); Duke University Medical Center, Durham, NC (United States); Schaal, J; Liu, W [Duke University, Durham, North Carolina (United States); Cai, J [Duke University Medical Center, Durham, NC (United States)

    2015-06-15

    Purpose: To develop, validate, and evaluate a methodology for determining dosimetry for intratumoral injections of elastin-like-polypeptide (ELP) brachytherapy nanoparticles. These organic-polymer-based nanoparticles are injectable, biodegradable, and genetically tunable. We present a genetically encoded polymer-solution, composed of novel radiolabeled-ELP nanoparticles that are custom-designed to self-assemble into a local source upon intratumoral injection. Our preliminary results of a small animal study demonstrate 100% tumor response, effective radionuclide retention-rates, strong in vivo stability, and no polymer-induced toxicities. While our approach is therefore highly promising for improved brachytherapy, the current workflow lacks a dosimetry framework. Methods: We are developing a robust software framework that provides image-guided dosimetric-planning capabilities for ELP brachytherapy. The user graphically places ELP injection sites within a µCT-planning-image, and independently defines each injection volume, concentration, and radioisotope to be used. The resulting internal dosimetry is then pre-determined by first modeling post-injection ELP advection-diffusion, and then calculating the resulting dose distribution based on a point- dose-kernel-convolution algorithm. We have experimentally measured ELP steady-state concentrations via µSPECT acquisition, and validated our dose calculation algorithm against Monte Carlo simulations of several radioactivity distributions. Finally, we have investigated potential advantages and limitations of various ELP injection parameters. Results: The µSPECT results demonstrated inhomogeneous steady-state distributions of ELP in tissue, and Monte Carlo radioactivity distributions were designed accordingly. Our algorithm yielded a root-mean-square-error of less than 2% for each distribution tested (average root-mean-square-error was 0.73%). Dose-Volume-Histogram analysis of five different plans showed how strategic

  14. Pediatric peri-operative fractionated high-dose-rate brachytherapy for recurrent Wilms’ tumor using a reconstructed Freiburg flap

    Directory of Open Access Journals (Sweden)

    Emily Flower

    2016-10-01

    Full Text Available Purpose : To report peri-operative fractionated high-dose-rate (HDR brachytherapy with a 3D customized Freiburg flap applicator to treat locally recurrent Wilms’ tumor, followed by immediate hyperthermic intraperitoneal chemotherapy for a 16-year-old with a second recurrence of nephroblastoma (Wilms’ tumor. Material and methods: The tumor was excised and surgical bed was treated with fractionated HDR brachytherapy using a Freiburg flap applicator. Hyperthermic intraperitoneal chemotherapy was performed immediately after the removal of brachytherapy applicator. Results: The Freiburg flap was successfully reconstructed to enable delivery of conformable peri-operative HDR brachytherapy. The clinical target volume (CTV D90 was 26 Gy in 5 fractions. Conclusions : Peri-operative fractionated HDR brachytherapy with a customized Freiburg flap applicator was delivered successfully across a large multi-disciplinary team.

  15. Single-fraction high-dose-rate brachytherapy using real-time transrectal ultrasound based planning in combination with external beam radiotherapy for prostate cancer: dosimetrics and early clinical results

    Directory of Open Access Journals (Sweden)

    Olivier Lauche

    2016-04-01

    Full Text Available Purpose : To validate the feasibility of a single-fraction high-dose-rate brachytherapy (HDRBT boost for prostate cancer using real-time transrectal ultrasound (TRUS based planning. Material and methods : From August 2012 to September 2015, 126 patients underwent a single-fraction HDRBT boost of 15 Gy using real-time TRUS based planning. External beam radiation therapy (EBRT (37.5 Gy/15 fractions, 44 Gy/22 fractions, or 45 Gy/25 fractions was performed before (31% or after (69% HDRBT boost. Genito-urinary (GU and gastro-intestinal (GI toxicity were assessed 4 and 12 months after the end of combined treatment using the international prostate symptom score scale (IPSS and the common terminology criteria for adverse events (CTCAE v3.0. Results : All dose-planning objectives were achieved in 90% of patients. Prostate D 90 ≥ 105% and ≤ 115% was achieved in 99% of patients, prostate V 150 ≤ 40% in 99%, prostate V 200 < 11% in 96%, urethra D 10 < 120% for 99%, urethra V 125 = 0% in 100%, and rectal V 75 < 1 cc in 93% of patients. Median IPSS score was 4 at baseline and did not change at 4 and 12 months after combined treatment. No patients developed ≥ grade 2 GI toxicity. With a median follow-up of 10 months, only two patients experienced biochemical failure. Among patients who didn’t receive ADT, cumulative percentage of patients with PSA ≤ 1 ng/ml at 4 and 18 months was respectively 23% and 66%. Conclusions : Single-fraction HDRBT boost of 15 Gy using real-time TRUS based planning achieves consistently high dosimetry quality. In combination with EBRT, toxicity outcomes appear promising. A longer follow-up is needed to assess long-term outcome and toxicities.

  16. Results from Effervescent Spray Atomization for MCB and a preliminary Proposal for Field Experiments

    Science.gov (United States)

    Neukermans, A.; Cooper, G. F.; Foster, J. D.; Galbraith, L. K.; Jain, S.; Ormond, R.

    2014-12-01

    We report on the preliminary results of spraying saltwater using a variant of effervescent spray atomization (ESA), for the purpose of producing salt nuclei for Marine Cloud Brightening (MCB). ESA is a well known industrial method, where air and water are mixed, to produce a choked two phase flow in a nozzle. The choked flow leaves a pressure residue at the nozzle exit which produces very efficient atomization. The resulting measured salt aerosol appears to be smaller than what is expected from current ESA theories. As measured with standard and well calibrated standard aerosol instruments, the distribution of the salt nuclei has an approximately log normal distribution with mean diameter of 60-80 nm and a GSD close to 2. Measured by electrostatic precipitation of the aerosol on a Si wafer and SEM observation, the median diameter is almost 1.5-2x as large, and this discrepancy has to date not been fully resolved. While the observed median diameter is perhaps somewhat on the low side for efficient conversion in the clouds, this nuclei distribution should be useful for preliminary field experiments. Assuming this distribution, with very simple means, a single small nozzle 150 um in diameter produces 5.3 x1012 nuclei/sec. A few hundred nozzles would be sufficient to produce 1015 nuclei/sec, requiring a power of only 25 kW, although errors on the tail end of the distribution could easily double this figure. To lift the spray, we envision the nozzles easily integrated in standard snowmaking machines, which are estimated by their manufactures to lift the nuclei from 50-100 m in the air, requiring another 20 kW of power. In cooperation with and under the scientific guidance of the U. of Washington, we propose to develop a set of staggered MCB experimental tests in Central California, first on land, and subsequently over the ocean. While this method may not be the ultimate one desired for full deployment (If ever), its simplicity, low cost and ease of deployment would seem

  17. Preliminary Tests and Results Concerning Integration of Sentinel-2 and Landsat-8 OLI for Crop Monitoring

    Directory of Open Access Journals (Sweden)

    Andrea Lessio

    2017-11-01

    Full Text Available The Sentinel-2 data by European Space Agency were recently made available for free. Their technical features suggest synergies with Landsat-8 dataset by NASA (National Aeronautics and Space Administration, especially in the agriculture context were observations should be as dense as possible to give a rather complete description of macro-phenology of crops. In this work some preliminary results are presented concerning geometric and spectral consistency of the two compared datasets. Tests were performed specifically focusing on the agriculture-devoted part of Piemonte Region (NW Italy. Geometric consistencies of Sentinel-2 and Landsat-8 datasets were tested “absolutely” (in respect of a selected reference frame and “relatively” (one in respect of the other by selecting, respectively, 160 and 100 well distributed check points. Spectral differences affecting at-the-ground reflectance were tested after images calibration performed by dark object subtraction approach. A special focus was on differences affecting derivable NDVI and NDWI spectral indices, being the most widely used in the agriculture remote sensing application context. Results are encouraging and suggest that this approach can successfully enter the ordinary remote sensing-supported precision farming workflow.

  18. Gas enhanced magnetic resonance angiography of the cerebrum using carbon dioxide and oxygen - preliminary results

    DEFF Research Database (Denmark)

    Pedersen, Mads Møller; Hansen, Kristoffer Lindskov; Ohlhues, Anders

    and the meninges may obscure the signal from the arteries of interest. It is known that oxygen enhances the T1-weighted signal and that carbon dioxide increases the arterial blood flow. This paper presents preliminary results of gas enhanced MRA using combinations of atmospheric air, O2 and CO2. Subjects...... and Methods Two healthy volunteers were scanned during inhalation of three different gas mixtures: Gas I (air), Gas II (5% CO2, 21 % O2, 74 % N2), Gas III (5% CO2, 95% O2). For each gas mixture a time of flight (TOF) series on the cerebral arteries was performed. Following each TOF series an ECG-gated phase...... compared. Results The TOF series showed an increase in MRA signal and vessel conspicuousness, when adding CO2 to air (gas I vs. gas II) and an additional increase was seen on MRA when adding O2 to CO2 (gas II vs. gas III). The increase in MRA signal was present on both volunteers. The volume flow increased...

  19. Connecting the disconnected: Preliminary results and lessons learned from a telepsychology initiative with special management inmates.

    Science.gov (United States)

    Batastini, Ashley B; Morgan, Robert D

    2016-08-01

    The use of telepsychology, such as videoconferencing (VC) systems, has been rapidly increasing as a tool for the provision of mental health services to underserved clients in difficult to access settings. Inmates detained in restrictive housing appear to be at an increased risk of experiencing emotional and behavioral disturbances compared to their general population counterparts, yet they are less likely to receive appropriate treatment due to security constraints. The primary purpose of this article is to describe the process of implementing a novel telepsychology intervention specifically designed to offer group therapy to high-security, administratively segregated inmates. In addition, preliminary results on treatment and therapeutic process outcomes in a sample of 49 participants are reported. Although some evidence indicated that telepsychology was less preferred than in-person sessions, group differences on measures of psychological functioning and criminal thinking were not found across 3 conditions (telepsychology, in-person, and a no-treatment control). Furthermore, a number of limitations associated with program implementation and study design suggest that results be interpreted with caution and should not be used to discount the use of telepsychology as a viable treatment delivery option. Recommendations for future development and evaluation of telepsychological programs are discussed within the context of correctional settings and beyond. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  20. New magnetotelluric soundings in the Mt. Somma-Vesuvius volcanic complex. Preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Manzella, A.; Volpi, G. [Consiglio Nazionale delle Ricerche, Pisa (Italy). Ist. Internazionale per le Ricerche Geotermiche; Zaja, A. [Padua Univ., Padua (Italy). Dipt. di Geologia, Paleontologia e Geofisica

    2000-04-01

    The work reports the preliminary results of ten magnetotelluric (MT) soundings recorded in single-site mode above the Mt. Somma-Vesuvius volcanic area in 1997. The quality of data decreases going further from the caldera and approaching the sources of electromagnetic incoherent noise such as villages, antennas and repeaters. After a very accurate data analysis, the apparent resistivity and phase curves were interpreted with a 1D modelling instead a 2D one as it seems a more appropriate interpretative approach looking at the morphology of the curves and taking into account the 3 D geological conditions of the area. The results show an extended conductive structure at a depth of 0.3-1.2 km. It could be connected with a change in the physico-chemical characteristics of the volcano-sedimentary define the response MT curves for sites above this particular volcanic structure. This approach seems to be very interesting in view of specific interpretative targets, such as dimension and position of the magma chamber, when planning future MT surveys.

  1. Reconstructive microsurgery of the fallopian tube with the carbon dioxide laser - procedures and preliminary results.

    Science.gov (United States)

    Bellina, J H

    1981-01-01

    In 1974 the carbon dioxide laser was adapted to the operating microscope for reconstructive pelvic surgery. A protocol was designed to test the efficacy of this surgical modality and a new study begun. Complete documentation of laparoscopic findings, surgical technique, and pre- and post-operative hysterosalpingograms are kept on videotape. One hundred cases will be entered into this study. Patency and pregnancy failures will be compared with patency and pregnancy successes to determine, if possible, the reasons for failure. In this paper detailed descriptions of the surgical techniques employed in the first 61 cases are presented. PRELIMINARY RESULTS in terms of patency and pregnancy experience to date are reported. Eighty-two couples have been evaluated at the Reproductive Biology Unit. Sixty-one cases have undergone fertility enhancement laser microsurgery and/or interim medical management prior to surgery for infertility. Bilateral patency or patency of the only existing fallopian tube was demonstrated post-treatment in 93% or 57 of the cases. Eliminating those cases who are not at risk of pregnancy due to elective contraception or medical prohibition during Danocrine therapy (28), conception has occurred in 10 of 33 patients. This represents approximately one of every three patients at risk. Considering the limited exposure to pregnancy, these results are very encouraging.

  2. Preliminary experimental results of tungsten wire-array Z-pinches on primary test stand

    Science.gov (United States)

    Huang, Xian-Bin; Zhou, Shao-Tong; Dan, Jia-Kun; Ren, Xiao-Dong; Wang, Kun-Lun; Zhang, Si-Qun; Li, Jing; Xu, Qiang; Cai, Hong-Chun; Duan, Shu-Chao; Ouyang, Kai; Chen, Guang-Hua; Ji, Ce; Wei, Bing; Feng, Shu-Ping; Wang, Meng; Xie, Wei-Ping; Deng, Jian-Jun; Zhou, Xiu-Wen; Yang, Yi

    2015-07-01

    The Primary Test Stand (PTS) developed at the China Academy of Engineering Physics is a 20 TW pulsed power driver, which can deliver a ˜10 MA, 70 ns rise-time (10%-90%) current to a short-circuit load and has important applications in Z-pinch driven inertial confinement fusion and high energy density physics. Preliminary results of tungsten wire-array Z-pinch experiments on PTS are presented. The load geometries investigated include 15-mm-tall cylindrical single and nested arrays with diameter ranging from 13 mm to 30 mm, consisting of 132-300 tungsten wires with 5-10 μm in diameter. Multiple diagnostics were fielded to characterize the x-ray radiation from wire-array Z pinches. The x-ray peak power (˜50 TW) and total radiated energy (˜500 kJ) were obtained from a single 20-mm-diam array with 80-ns stagnation time. The highest x-ray peak power up to 80 TW with 2.4 ns FWHM was achieved by using a nested array with 20-mm outer diameter, and the total x-ray energy from the nested array is comparable to that of single array. Implosion velocity estimated from the time-resolved image measurement exceeds 30 cm/μs. The detailed experimental results and other findings are presented and discussed.

  3. A Morphing Technique Applied to Lung Motions in Radiotherapy: Preliminary Results

    Directory of Open Access Journals (Sweden)

    R. Laurent

    2010-01-01

    Full Text Available Organ motion leads to dosimetric uncertainties during a patient’s treatment. Much work has been done to quantify the dosimetric effects of lung movement during radiation treatment. There is a particular need for a good description and prediction of organ motion. To describe lung motion more precisely, we have examined the possibility of using a computer technique: a morphing algorithm. Morphing is an iterative method which consists of blending one image into another image. To evaluate the use of morphing, Four Dimensions Computed Tomography (4DCT acquisition of a patient was performed. The lungs were automatically segmented for different phases, and morphing was performed using the end-inspiration and the end-expiration phase scans only. Intermediate morphing files were compared with 4DCT intermediate images. The results showed good agreement between morphing images and 4DCT images: fewer than 2 % of the 512 by 256 voxels were wrongly classified as belonging/not belonging to a lung section. This paper presents preliminary results, and our morphing algorithm needs improvement. We can infer that morphing offers considerable advantages in terms of radiation protection of the patient during the diagnosis phase, handling of artifacts, definition of organ contours and description of organ motion.

  4. Investigation of intraoperative brain deformation using a 1.5-T interventional MR system: preliminary results.

    Science.gov (United States)

    Maurer, C R; Hill, D L; Martin, A J; Liu, H; McCue, M; Rueckert, D; Lloret, D; Hall, W A; Maxwell, R E; Hawkes, D J; Truwit, C L

    1998-10-01

    All image-guided neurosurgical systems that we are aware of assume that the head and its contents behave as a rigid body. It is important to measure intraoperative brain deformation (brain shift) to provide some indication of the application accuracy of image-guided surgical systems, and also to provide data to develop and validate nonrigid registration algorithms to correct for such deformation. We are collecting data from patients undergoing neurosurgery in a high-field (1.5 T) interventional magnetic resonance (MR) scanner. High-contrast and high-resolution gradient-echo MR image volumes are collected immediately prior to surgery, during surgery, and at the end of surgery, with the patient intubated and lying on the operating table in the operative position. In this paper we report initial results from six patients: one freehand biopsy, one stereotactic functional procedure, and four resections. We investigate intraoperative brain deformation by examining threshold boundary overlays and difference images and by measuring ventricular volume. We also present preliminary results obtained using a nonrigid registration algorithm to quantify deformation. We found that some cases had much greater deformation than others, and also that, regardless of the procedure, there was very little deformation of the midline, the tentorium, the hemisphere contralateral to the procedure, and ipsilateral structures except those that are within 1 cm of the lesion or are gravitationally above the surgical site.

  5. OBS seismic data preliminary results: Manila subduction zone (21°N)

    Science.gov (United States)

    Zhao, M.; Liu, S.; Sun, L.; Sibuet, J. C.; Zhang, J.; Chen, C.; Qiu, X.

    2016-12-01

    A two-dimensional ocean bottom seismometer (OBS) survey was performed in 2015, along an E-W trending line (OBS2015-2) located in front of the Manila subduction zone. The preliminary results show that OBS data are of high quality for the whole experiment. Seismic phases (such as Pg and PmP) are very clear in the OBSs' record sections. They are further identified by forward modeling using the Rayinvr software. The reflective seismic phases from the Moho interface (PmP) are observed in all OBS sections. The identification of these PmP phases used simultaneously with Fast and Tomo2D tomography results shows that the nature of the crust is essentially continental, not oceanic, except perhaps close to the trench. The obvious PmP phases in the incoming plate along the Manila Trench subduction zone, will further provide good constraints concerning the nature and evolution of the incoming plate in the Manila subduction zone. This research was granted by the Natural Science Foundation of China (91428204, 41176053) and the scientific cruise (NORC2015-8) by the R/V Shiyan 2.

  6. Reprocessing the Elliptical Orbiting Galileo Satellites E14 and E18: Preliminary Results

    Science.gov (United States)

    Männel, Benjamin

    2017-04-01

    In August 2014, the two Galileo satellites FOC-1 (E18) and FOC-2 (E14) were - due to a technical problem - launched into a wrong, elliptic orbit. In a recovery mission a series of orbit maneuvers were performed to raise the perigee to an altitude where both spacecrafts could be introduced to the Galileo navigation service. After this period of orbit maintenance both satellites started to transmit navigation signals at November 29, 2014 (E18) and March 17, 2015 (E14). However, as it was not possible to recover the nominal orbits due to propellant limitations, both spacecrafts orbit the Earth with a numerical eccentricity of 0.16 and an inclination of 50.2°. Very soon, it was assumed that both satellites could be highly useful for studies on general relativity, especially as the Galileo spacecrafts are equipped with very stable passive hydrogen masers. A prerequisite for dedicated studies in this field are highly accurate satellite orbits and clock corrections. Preliminary results for orbit and satellite clock determination will be presented based on an initial reprocessing over the past 2.5 years. The presentation focuses firstly on orbit modeling aspects with respect to the elliptically orbits. Secondly the derived clock corrections for the on-board passive clocks are assessed with respect to the reference clock at ground stations. The results will be discussed also with respect to the proposed Galileo-based studies on the gravitational redshift.

  7. Preliminary Results from an Investigation into Nanostructured Nuclear Radiation Detectors for Non-Proliferation Applications

    Energy Technology Data Exchange (ETDEWEB)

    ,

    2012-10-01

    In recent years, the concept of embedding composite scintillators consisting of nanosized inorganic crystals in an organic matrix has been actively pursued. Nanocomposite detectors have the potential to meet many of the homeland security, non-proliferation, and border and cargo-screening needs of the nation and, by virtue of their superior nuclear identification capability over plastic, at roughly the same cost as plastic, have the potential to replace all plastic detectors. Nanocomposites clearly have the potential of being a gamma ray detection material that would be sensitive yet less expensive and easier to produce on a large scale than growing large, whole crystals of similar sensitivity. These detectors would have a broad energy range and a sufficient energy resolution to perform isotopic identification. The material can also be fabricated on an industrial scale, further reducing cost. This investigation focused on designing and fabricating prototype core/shell and quantum dot (QD) detectors. Fourteen core/shell and four QD detectors, all with the basic consistency of a mixture of nanoparticles in a polymer matrix with different densities of nanoparticles, were prepared. Nanoparticles with sizes <10 nm were fabricated, embedded in a polystyrene matrix, and the resultant scintillators’ radiation detector properties were characterized. This work also attempted to extend the gamma energy response on both low- and high-energy regimes by demonstrating the ability to detect low-energy and high-energy gamma rays. Preliminary results of this investigation are consistent with a significant response of these materials to nuclear radiation.

  8. Preliminary results of high-frequency surface wave tomography along MASE line

    Science.gov (United States)

    Iglesias, A.; Clayton, R. W.; Pacheco, J.; Singh, S. K.; Pérez-Campos, X.; Valdés-González, C.

    2006-12-01

    The MASE array is a line of 100 broadband seismic stations, perpendicular to the Middle American Trench, , that traverses Mexico from the Pacific coast to a point close to the Gulf of Mexico. We present preliminary results of a group-velocity tomographic inversion along the line and of an inversion of local dispersion curves reconstructed from the tomographic images. The MASE array was complemented with data from seismological stations operated by the Mexican Seismological Service (SSN), to make the images more 3D. In order to compute the tomographic maps, we determine group-velocity dispersion curves for Rayleigh waves (5-50s) from a set of ~50 well located earthquakes recorded by MASE and SSN stations. These dispersion curves map average group velocities between each earthquake-station combination. We construct a .125 x .125 km grid over central and south Mexico. At each element, the observed group velocity for each period is inverted to obtain a group-velocity value. Using the images for several periods, we construct a local dispersion curve for each MASE station. Finally, these local dispersion curves are individually inverted using a layered homogeneous medium and a simulated annealing algorithm to obtain an S-wave velocity crustal structure. Results show variations in crustal thicjness along the MASE line, as well as indication of a mantle wedge under the Mexcian Volcanic Belt.

  9. Biological image construction by using Raman radiation and Pca: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Martinez E, J. C. [IPN, Unidad Profesional Interdisciplinaria de Ingenieria, Campus Guanajuato, Av. Mineral de Valenciana 200, Col. Fracc. Industrial Puerto Interior, 36275 Silao, Guanajuato (Mexico); Cordova F, T. [Universidad de Guanajuato, DIC, Departamento de Ingenieria Fisica, Loma del Bosque No. 103, Col. Lomas del Campestre, 37150 Leon, Guanajuato (Mexico); Hugo R, V., E-mail: jcmartineze@ipn.mx [Universidad de Guadalajara, Centro Universitario de Tonala, Morelos No. 180, 69584 Tonala, Jalisco (Mexico)

    2015-10-15

    Full text: In the last years, the Raman spectroscopy (Rs) technique has had some applications in the study and analysis of biological samples, due to it is able to detect concentrations or presence of certain organic and inorganic compounds of medical interest. In this work, raw data were obtained through measurements in selected points on a square regions in order to detect specific organic / inorganic compounds on biological samples. Gold nano stars samples were prepared and coated with membrane markers (CD 10+ and CD 19+) and diluted in leukemic B lymphocytes. Each data block was evaluated independently by the method of principal component analysis (Pca) in order to find representative dimensionless values (Cp) for each Raman spectrum in a specific coordinate. Each Cp was normalized in a range of 0-255 in order to generate a representative image of 8 bits of the region under study. Data acquisition was performed with Raman microscopy system Renishaw in Via in the range of 550 to 1700 cm-1 with a 785 nm laser source, with a power of 17 m W and 15 s of exposure time were used for each spectrum. In preliminary results could detect the presence of molecular markers CD 10+ and CD 19+ with gold nano stars and discrimination between both markers. The results suggest conducting studies with specific concentrations organic and inorganic materials. (Author)

  10. Application of a PCR method for the diagnosis of ulcerative enteritis: preliminary results

    Directory of Open Access Journals (Sweden)

    Fabrizio Agnoletti

    2010-01-01

    Full Text Available Ulcerative enteritis or “quail disease” is an acute clostridial infection of young birds reported in many avian species, chicken and turkey included. Clostridium colinum is the causative agent of ulcerative enteritis and because of the difficulties bound to the isolation and identification of this bacterium by means of classic bacteriological techniques, its detection appears very hard and the prevalence of this disease could be underestimated. To investigate the diffusion of C. colinum in enteric disease of birds, a recently developed PCR protocol was applied to 42 cultural broths previously inoculated with organs and intestinal samples collected from diseased subjects. PCR-positive broths were cultivated to attempt the isolation of C. colinum. Samples collected from positive birds were subjected to histological examinations. 4 birds (3 broilers chickens and 1 pigeon resulted PCR-positive and, in one case, C. colinum was isolated. Gross and histological lesions of positive birds were compatible with those described in other ulcerative enteritis outbreaks. These preliminary results demonstrates that C. colinum is sporadically implicated in enteric diseases of broiler chickens (14.2%. In addition, the PCR assay proved to be an useful and reliable instrument to support the diagnosis of ulcerative enteritis and to facilitate the isolation of C. colinum.

  11. A fully automated method for segmentation and classification of local field potential recordings. Preliminary results.

    Science.gov (United States)

    Diaz-Parra, Antonio; Canals, Santiago; Moratal, David

    2017-07-01

    Identification of brain states measured with electrophysiological methods such as electroencephalography and local field potential (LFP) recordings is of great importance in numerous neuroscientific applications. For instance, in Brain Computer Interface, in the diagnosis of neurological disorders as well as to investigate how brain rhythms stem from synchronized physiological mechanisms (e.g., memory and learning). In this work, we propose a fully automated method with the aim of partitioning LFP signals into stationary segments as well as classifying each detected segment into three different classes (delta, regular theta or irregular theta rhythms). Our approach is computationally efficient since the process of detection and partition of signals into stationary segments is only based on two features (the variance and the so-called spectral error measure) and allow the classification at the same time. We developed the algorithm upon analyzing six anesthetized rats, resulting in a true positive rate of 97.5%, 91.8% and 79.1% in detecting delta, irregular theta and regular theta rhythms, respectively. This preliminary quantitative evaluation offers encouraging results for further research.

  12. Preliminary Results from the PrimEx-II experiment at Jefferson Lab

    Energy Technology Data Exchange (ETDEWEB)

    Gasparian, Ashot [NCA& T, Greensboro, NC; Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2016-06-01

    Properties of the neutral pion, as the lightest hadron in Nature, are most sensitive to the basic symmetries and their partial breaking effects in the theory of the strong interaction (QCD). In particular, the po →gg decay width is primarily defined by the spontaneous chiral symmetry breaking effect (chiral anomaly) in QCD. The next order corrections to the anomaly have been shown to be small and are known to a 1% precision level. The PrimEx Collaboration at JLab has developed and performed two Primakoff type experiments to measure the po →gg decay width with a similar precision. The published result from the PrimEx-I experiment, G(p0 →gg ) = 7.82±0.14 (stat.)±0.17 (syst.) eV, was a factor of two more precise than the average value quoted in PDG-2010 [1]. The second experiment was performed in 2010 with a goal of 1.4% total uncertainty to address the next-to-leading-order theory calculations. The preliminary results from the PrimEx-II experiment are presented and discussed in this note.

  13. Preliminary Report: DESiGN and Test Result of KSR-3 Rocket Magnetometers

    Directory of Open Access Journals (Sweden)

    Hyo-Min Kim

    2000-12-01

    Full Text Available The solar wind contributes to the formation of unique space environment called the Earth's magnetosphere by various interactions with the Earth's magnetic field. Thus the solar-terrestrial environment affects the Earth's magnetic field, which can be observed with an instrument for the magnetic field measurement, the magnetometer usually mounted on the rocket and the satellite and based on the ground observatory. The magnetometer is a useful instrument for the spacecraft attitude control as well as the Earth's magnetic field measurements for a scientific purpose. In this paper, we present the preliminary design and test results of the two onboard magnetometers of KARI's (Korea Aerospace Research Institute sounding rocket, KSR-3, which will be launched four times during the period of 2001-02. The KSR-3 magnetometers consist of the fluxgate magnetometer, MAG/AIM (Attitude Information Magnetometer for acquiring the rocket flight attitude information, and of the search-coil magnetometer, MAG/SIM (Scientific Investigation Magnetometer for the observation of the Earth's magnetic field fluctuations. With the MAG/AIM, the 3-axis attitude information can be acquired by the comparison of the resulting dc magnetic vector field with the IGRF (International Geomagnetic Reference Field. The Earth's magnetic field fluctuations ranging from 10 to 1,000 Hz can also be observed with the MAG/SIM measurement.

  14. Fixation of the midclavicular fractures with the titanium elastic nails in adults – preliminary results

    Directory of Open Access Journals (Sweden)

    Matej Drobnič

    2005-06-01

    Full Text Available Background: Elastic intramedullary fixation is an established operative treatment for fractures in childhood, which is only exceptionally used in adults. A modified intramedullary fixation of midclavicular fractures in adults with titanium elastic nails is presented.Methods: The group was comprised of five adult patients with shortened midclavicular fractures. The prior conservative treatment had been ineffective in three cases, whereas poor functional outcome was expected in the other two, as a result of fracture shortening or instability. According to the new technique titanium elastic nails were first placed into the intramedullar channel of the distal fragment through the fracture, using a mini-open exposure. The nails were advanced retrogradely into the proximal fragment to achieve a stable fixation. The initial post-operative rehabilitation included pendulary exercises in a sling. Active exercises in the range of pain allowance were introduced after the operative wounds had been healed.Results: All fractures were consolidated in the physiological position. The patients were capable of painless movements with the shoulder on the operated side in the full range of motion after six weeks. One transitory complication in the form of skin and subcutaneous decubitus over the protruded nail tip was noted without an influence on the end result.Conclusions: The preliminary results in a limited number of patients showed efficient consolidation of the midclavicular fractures in adults treated with intramedullar titanium elastic nails. The functional results and low invasivity of the procedure support its further use in treatment of midclavicular fractures, which fail to heal conservatively, or which are expected to result in poor functional or cosmetic outcome.

  15. Use of brachytherapy with permanent implants of iodine-125 in localized prostate cancer; La curietherapie par implants permanents d'I-125 dans le cancer localise de la prostate

    Energy Technology Data Exchange (ETDEWEB)

    Bladou, F.; Serment, G. [Hopital Salvador, Service d' Urologie, 13 - Marseille (France); Salem, N.; Simonian, M. [Hopital Salvador, Dept. de Radiotherapie, 13 - Marseille (France); Rosello, R.; Ternier, F. [Institut Paoli-Calmettes, Dept. de Radiologie, 13 - Marseille (France)

    2002-07-01

    Approximately 15,000 cases of early stage prostate cancer T1 and T2 are diagnosed every year in France by testing for PSA and performing prostatic biopsies. The treatment of these localized forms is based in most cases on radical prostatectomy or nn external beam radiotherapy. Although the ontological results obtained by these two therapeutic methods are satisfactory and equivalent in the long term, the side effects can be important. For a number of years, trans-perineal brachytherapy using permanent implants of iodine -125 or palladium-103 has proved itself as an alternative therapy with equivalent medium to long-term results. The low urinary, digestive and sexual side effects of prostate brachytherapy are important reasons for the enthusiasm among patients and the medical community for this therapy and the growing number of applications and centres which practice it. In September 1998 we started the prostate brachytherapy programmes- in Marseilles with close collaboration between the department of urology of the Hopital Salvator, and the departments of radiotherapy, medical imaging and medical physics of the Institut Paoli-Calmettes. To date, around 250 patients with localized adenocarcinoma of the prostate have benefited from this alternative therapy in our centre. Preliminary results, with a 3 year-follow-up, are comparable to results published in the literature by pioneer teams. (authors)

  16. Brachytherapy, A viable option of globe salvage in treatment of large ciliary body melanocytoma

    Directory of Open Access Journals (Sweden)

    Mahesh P Shanmugam

    2014-01-01

    Full Text Available We report a case of large histopathologically proven melanocytoma of the ciliary body in a 15-year-old male, presented with rapid extraocular growth following incisional biopsy with scleral patch graft. We chose brachytherapy with Ruthenium 106 plaque over enucleation as the later was refused by the parents. The initial apical height of the tumor was 14.2 mm on ultrasonography. Two weeks after brachytherapy, the mass regressed to a size of 8.1 mm and 1 year later to 6.7 mm. This is the first case report showing the response of brachytherapy to ciliary body melanocytoma, which results in ocular and visual acuity salvation with considerable decreased in size of the tumor. The authors conclude that brachytherapy is an option in the management of non-resectable melanocytoma of the ciliary body.

  17. Perioperative Interstitial High-Dose-Rate Brachytherapy for the Treatment of Recurrent Keloids

    DEFF Research Database (Denmark)

    Jiang, Ping; Baumann, René; Dunst, Jürgen

    2016-01-01

    PURPOSE: To prospectively evaluate high-dose-rate brachytherapy in the treatment of therapy-resistant keloids and report first results, with emphasis on feasibility and early treatment outcome. METHODS AND MATERIALS: From 2009 to 2014, 24 patients with 32 recurrent keloids were treated...... with immediate perioperative high-dose-rate brachytherapy; 3 patients had been previously treated with adjuvant external beam radiation therapy and presented with recurrences in the pretreated areas. Two or more different treatment modalities had been tried in all patients and had failed to achieve remission....... After (re-)excision of the keloids, a single brachytherapy tube was placed subcutaneously before closing the wound. The target volume covered the scar in total length. Brachytherapy was given in 3 fractions with a single dose of 6 Gy in 5 mm tissue depth. The first fraction was given within 6 hours...

  18. Coatings of nanoparticles applied to brachytherapy treatments

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, Andreza A.D.C.C.; Rostelato, Maria Elisa C.M.; Souza, Carla D.; Rodrigues, Bruna T.; Souza, Daiane C.B.; Zeituni, Carlos A.; Nogueira, Beatriz R., E-mail: ccg.andreza@gmail.com, E-mail: elisaros@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2017-07-01

    Brachytherapy is a treatment for cancer in which the radiation is placed close or in contact with the region to be treated saving the surrounding healthy tissues. Nanotechnology is the science that studies the properties of nanometric materials. Nanobrachytherapy in a new field that unites the advantages of brachytherapy with the small size in the nanoparticle, resulting in an even less invasive treatment. In view of the synthesis of the nanoparticles and their use, there is a fundamental role that is made by the coatings, which not only have the function of avoiding the aggregation of particles, but also stabilize and control their functional properties. Among the range of coatings, the most outstanding are polyethylene glycol (PEG) and gum arabica (GA). PEG improves the surface properties of nanoparticles and presents high stability under biomedical conditions. After the synthesis of gold nanoparticles was developed, PEG and gum arabica were successfully incorporated into the surface. In a vial of pyrex, 1 ml of coating agent and 1 ml of nanoparticles was left under gentle shaking for 2 hours. Incorporation was confirmed by DLS and HRTEM. GA requires further study. (author)

  19. A flattening filter for brachytherapy skin irradiation

    Science.gov (United States)

    Kron, Tomas; Haque, Mamoon; Foulkes, Kristie; Jeraj, Robert

    2002-03-01

    Radioactive sources in close contact offer an alternative to superficial radiation in the treatment of skin lesions. A flattening filter was designed for a lead surface applicator to improve the skin dose distribution of a high dose rate (HDR) brachytherapy unit (Nucletron). At three heights from the opening (10, 15 and 25 mm) of the cylindrical applicator, the 192Ir source can be driven into the centre of the applicator. Thin sheets of lead foil (0.2 mm) were cut into circular shapes and placed in the opening to build a cylindrical cone that acts as a flattening filter. The shape of the cone was optimized in an iterative process using a spreadsheet and the resulting dose distribution under the applicator was determined using radiosensitive film. The use of the filter improved the dose distribution in a plane perpendicular to the beam axis to be within +/-5% of the central axis dose. The present applicator and flattening filter together with an HDR brachytherapy unit offer an alternative for skin irradiation where a superficial unit is not available or will be replaced with a more flexible device. As the depth dose characteristics can be modified using different source-to-surface distances, the dose throughout the patient's skin can be shaped as desired by the radiation oncologist using a compensator design type approach.

  20. Calcareous nannoplankton and benthic foraminiferal assemblages from the Nazare Canyon (Portuguese continental margin): Preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Guerreiro, C; Oliveira, A; Rodrigues, A [Division of Marine Geology, Portuguese Hydrographic Institute (IH), Rua das Trinas 49, 1249-093 Lisboa (Portugal); Rosa, F [CIACOMAR, Algarve University, Av. 16 de Julho s/n 8700-311 Olhao (Portugal); Cachao, M; Fatela, F [Geology Center and Geology Department, FCUL, Bloco C6, 3o Piso, sala 6.3.57 Campo Grande 1749-016 Lisboa (Portugal)], E-mail: catarina.guerreiro@hidrografico.pt

    2009-01-01

    Submarine canyons are assumed to play an important role in oceanic/neritic circulation, marine productivity and sedimentary processes, acting as preferential conduits between the littoral and deep oceanic domain. Here we present first results of a comparative micropalaeontological study on calcareous nannoplankton and benthic foraminifera from surface sediments from the surroundings of the upper Nazare Canyon (Portuguese continental margin) and from the shelf north of the canyon. Regardless of the difficulty to distinguish taphonomical from (palaeo)ecological effects in such a complex and still poorly known marine system, the first results suggest that the canyon's hydro-sedimentary dynamic regime act as a prolongation of the shore/inner shelf hydrodynamic conditions towards west, preventing deposition and/or preservation of the smaller and fragile species of calcareous nannoplankton (e.g. E. huxleyi and G. ericsonii) and enhancing the record of the larger and more opportunistic ones (e.g. G. oceanica); and disturbing benthic foraminiferal productivity and/or diversity, or their preservation in the fossil record. Both calcareous nannoplankton and benthic foraminifera are more abundant off the canyon's domain, suggesting that its highly energetic thalweg conditions are probably filtering the fossil record in the sediment. Still, preliminary results suggest that the occurrence of persistent physical phenomena related with the canyon's morphology and proximity to the coast (e.g. solitary internal waves) may be locally promoting favourable conditions for calcareous nannoplankton, as shown by high values of nannoliths, chlorophyll a and 19' hexanoyloxyfucoxantine (unpublished data) north of the canyon's head. It is our goal to test this hypothesis in the near future by (a) studying multicore and surficial sediments from more recent surveys, and (b) calibrating the sediment results with water column data presently in process at the Institute of

  1. Rectal complications after prostate brachytherapy.

    Science.gov (United States)

    Shah, Shimul A; Cima, Robert R; Benoit, Eric; Breen, Elizabeth L; Bleday, Ronald

    2004-09-01

    Prostate brachytherapy is gaining wide popularity as an alternative to resection for the treatment of locally advanced prostate cancer. Rectal-urethral fistula after prostate brachytherapy is a rare but serious complication, and its incidence, presentation, risk factors, and clinical management have not been well described. From January 1997 to October 2002, seven patients with rectal-urethral fistulas were referred to two institutions (Brigham and Women's Hospital and West Roxbury Veteran's Administration Hospital) of a major teaching referral center. Clinical presentation, risk factors, prostate staging, and clinical management were examined in a retrospective fashion. Seven rectal-urethral fistulas developed from roughly 700 (1 percent) patients treated with prostate brachytherapy for prostate cancer. The average patient age was 67.7 years, preimplant prostate-specific antigen was 7.1, and Gleason score was 3+3. Symptoms occurred at a mean of 27.3 months after prostate brachytherapy was started and included anorectal pain (57 percent), clear mucous discharge (57 percent), diarrhea (43 percent), and rectal ulceration (43 percent). Coronary artery disease was a common comorbidity (71 percent). Previous transurethral resection of prostate (28 percent) and pelvic irradiation or external beam radiation therapy (14 percent) were not associated with increased risk of rectal-urethral fistula. All patients underwent a diverting colostomy (86 percent) or ileostomy (14 percent), and four patients went on to have definitive therapy. Definitive resection was performed between 5 and 43 months after diverting ostomy and was chosen on the basis of comorbid disease, quality of life, and degree of operation. Two patients required a second diversion after definitive resection because of anorectal pain and a colocutaneous fistula. Postoperative complications included myocardial infarction (14 percent), blood transfusion (14 percent), and bowel perforation (14 percent). Patients

  2. Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results

    Science.gov (United States)

    Bigio, Irving J.; Brown, Stephen G.; Briggs, Gavin M.; Kelley, Christine; Lakhani, Sunil; Pickard, David; Ripley, Paul M.; Rose, Ian; Saunders, Christobel

    2000-04-01

    We report on the first stages of a clinical study designed to test elastic-scattering spectroscopy, medicated by fiberoptic probes, for three specific clinical applications in breast-tissue diagnosis: (1) a transdermal-needle (interstitial) measurement for instant diagnosis with minimal invasiveness similar to fine-needle aspiration but with sensitivity to a larger tissue volume, (2) a hand-held diagnostic probe for use in assessing tumor/resection margins during open surgery, and (3) use of the same probe for real-time assessment of the `sentinel' node during surgery to determine the presence or absence of tumor (metastatic). Preliminary results from in vivo measurements on 31 women are encouraging. Optical spectra were measured on 72 histology sites in breast tissue, and 54 histology sites in sentinel nodes. Two different artificial intelligence methods of spectral classification were studied. Artificial neural networks yielded sensitivities of 69% and 58%, and specificities of 85% and 93%, for breast tissue and sentinel nodes, respectively. Hierarchical cluster analysis yielded sensitivities of 67% and 91%, and specificities of 79% and 77%, for breast tissue and sentinel nodes, respectively. These values are expected to improve as the data sets continue to grow and more sophisticated data preprocessing is employed. The study will enroll up to 400 patients over the next two years.

  3. Preliminary results for the design, fabrication, and performance of a backside-illuminated avalanche drift detector

    Science.gov (United States)

    Qiao, Yun; Liang, Kun; Chen, Wen-Fei; Han, De-Jun

    2013-10-01

    The detection of low-level light is a key technology in various experimental scientific studies. As a photon detector, the silicon photomultiplier (SiPM) has gradually become an alternative to the photomultiplier tube (PMT) in many applications in high-energy physics, astroparticle physics, and medical imaging because of its high photon detection efficiency (PDE), good resolution for single-photon detection, insensitivity to magnetic field, low operating voltage, compactness, and low cost. However, primarily because of the geometric fill factor, the PDE of most SiPMs is not very high; in particular, for those SiPMs with a high density of micro cells, the effective area is small, and the bandwidth of the light response is narrow. As a building block of the SiPM, the concept of the backside-illuminated avalanche drift detector (ADD) was first proposed by the Max Planck Institute of Germany eight years ago; the ADD is promising to have high PDE over the full energy range of optical photons, even ultraviolet light and X-ray light, and because the avalanche multiplication region is very small, the ADD is beneficial for the fabrication of large-area SiPMs. However, because of difficulties in design and fabrication, no significant progress had been made, and the concept had not yet been verified. In this paper, preliminary results in the design, fabrication, and performance of a backside-illuminated ADD are reported; the difficulties in and limitations to the backside-illuminated ADD are analyzed.

  4. The relationship between team climate and interprofessional collaboration: Preliminary results of a mixed methods study.

    Science.gov (United States)

    Agreli, Heloise F; Peduzzi, Marina; Bailey, Christopher

    2017-03-01

    Relational and organisational factors are key elements of interprofessional collaboration (IPC) and team climate. Few studies have explored the relationship between IPC and team climate. This article presents a study that aimed to explore IPC in primary healthcare teams and understand how the assessment of team climate may provide insights into IPC. A mixed methods study design was adopted. In Stage 1 of the study, team climate was assessed using the Team Climate Inventory with 159 professionals in 18 interprofessional teams based in São Paulo, Brazil. In Stage 2, data were collected through in-depth interviews with a sample of team members who participated in the first stage of the study. Results from Stage 1 provided an overview of factors relevant to teamwork, which in turn informed our exploration of the relationship between team climate and IPC. Preliminary findings from Stage 2 indicated that teams with a more positive team climate (in particular, greater participative safety) also reported more effective communication and mutual support. In conclusion, team climate provided insights into IPC, especially regarding aspects of communication and interaction in teams. Further research will provide a better understanding of differences and areas of overlap between team climate and IPC. It will potentially contribute for an innovative theoretical approach to explore interprofessional work in primary care settings.

  5. Preliminary Results of Primary Gastrocnemius-Soleus Recession for Midfoot Charcot Arthropathy.

    Science.gov (United States)

    Laborde, J Monroe; Philbin, Terrence M; Chandler, Philip J; Daigre, Justin

    2016-04-01

    Background Treatment of Charcot arthopathy of the foot can be challenging. The goal of this investigation was to determine whether primary gastrocnemius-soleus recession could decrease rate of new ulcers, progression of deformity, and amputation in patients with Charcot arthropathy of the midfoot.Methods A retrospective chart review revealed 28 feet in 24 diabetic patients with radiographic evidence of Charcot arthropathy of the midfoot. They were treated with primary gastrocnemius-soleus recession. Eleven feet in 11 patients had concurrent plantar midfoot ulcers. Three feet in 3 patients were lost to follow-up. Twenty-five feet in 21 patients were followed for an average of 37 months postoperatively (range = 18-79).Results A favorable outcome was defined as healing of existing ulcers, no new ulcers, no obvious progression of deformity, and no amputation. Favorable outcomes were obtained in 22 of 25 feet (18 of 21 patients). Only one patient had a persistent ulcer after gastrocnemius-soleus recession. The other 10 patients with preexisting ulcers healed. Deformity of midfoot progressed in one patient, leading ultimately to transtibial amputation. Another patient developed a knee joint infection and had a transfemoral amputation at another institution.Discussion These preliminary data suggest that primary gastrocnemius-soleus recession is followed by a much lower rate of persistent, recurrent, and new ulceration than previously reported studies. Gastrocnemius-soleus recession seems to aid in the treatment of Charcot arthropathy of the midfoot. Level IV. © 2015 The Author(s).

  6. Trajectory planning method for reduced patient risk in image-guided neurosurgery: concept and preliminary results

    Science.gov (United States)

    Shamir, Reuben R.; Joskowicz, Leo; Antiga, Luca; Foroni, Roberto I.; Shoshan, Yigal

    2010-02-01

    We present a new preoperative planning method to quantify and help reduce the risk associated with needle and tool insertion trajectories in image-guided keyhole neurosurgery. The goal is to quantify the risk of a proposed straight trajectory, and/or to find the trajectory with the lowest risk to nearby brain structures based on pre-operative CT/MRI images. The method automatically computes the risk associated with a given trajectory, or finds the trajectory with the lowest risk to nearby brain structures based on preoperative image segmentation and on a risk volume map. The surgeon can revise the suggested trajectory, add a new one using interactive 3D visualization, and obtain a quantitative risk measure. The trajectory risk is evaluated based on the tool placement uncertainty, on the proximity of critical brain structures, and on a predefined table of quantitative geometric risk measures. Our preliminary results on a clinical dataset with eight targets show a significant reduction in trajectory risk and a shortening of the preoperative planning time as compared to the conventional method.

  7. Detection of thrombophlebitis with 111In-labeled anti-fibrin antibody: Preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Alavi, A.; Gupta, N.; Palevsky, H.I.; Kelley, M.A.; Jatlow, A.D.; Byar, A.A.; Berger, H.J. (Hospital of the Univ. of Pennsylvania, Philadelphia (USA))

    1990-02-01

    Deep venous thrombosis remains a major medical problem, affecting a large segment of the population and resulting in significant mortality and morbidity. Current techniques available for detecting deep venous thrombosis present limitations that may mitigate their potential benefit to the patient. Invasive techniques, such as ascending contrast venography, carry risks to the patient with regard to complications such as an allergic reaction to an iodine dye, adverse effects to renal functions, and clot formation in a normal vein. Noninvasive techniques, such as Doppler ultrasound and impedance plethysmography, evaluate only a limited segment of the venous bed. The need remains for a diagnostic technique that is safe, accurate, and widely accessible. A readily available noninvasive scintigraphic technique utilizing radiolabeled monoclonal anti-fibrin antibody may overcome some of these shortcomings. This imaging examination is quite effective in detecting clots in the lower extremities. Compared to contrast venography, {sup 111}In-labeled anti-fibrin antibody imaging appears to be as sensitive in identifying acute venous thrombosis. In addition, the preliminary data indicate that anticoagulation with heparin may interfere with adequate visualization of the clots with this technique.

  8. Preliminary clinical results of posterior lamellar keratoplasty through a sclerocorneal pocket incision.

    Science.gov (United States)

    Melles, G R; Lander, F; van Dooren, B T; Pels, E; Beekhuis, W H

    2000-10-01

    To report the preliminary results of a surgical technique for transplantation of posterior corneal tissue through a sclerocorneal pocket incision for corneal endothelial disorders. Retrospective, noncomparative, interventional cases series. In seven sighted human eyes, a deep stromal pocket was created across the cornea through a 9.0-mm superior scleral incision. A 7.0- or 7.5-mm diameter, posterior lamellar disc was excised and replaced by a 'same size' donor posterior disc, without suture fixation. The scleral incision was sutured. Intra- and postoperative complications, best spectacle-corrected visual acuity, keratometry, topography, biomicroscopy, pachymetry, and endothelial cell density were evaluated. Six to 12 months after surgery, all transplants were clear and in position. Best spectacle-corrected visual acuity was limited by preexisting maculopathies in two eyes and varied from 20/80 to 20/20. Postoperative astigmatism averaged 1. 54 diopters (D; standard deviation [SD] +/- 0.81 D), pachymetry averaged 0.49 mm (SD +/- 0.09 mm), and postoperative endothelial cell density averaged 2520 cells/mm(2) (SD +/- 340 cells/mm(2)). In one eye, a microperforation occurred during stromal pocket dissection so that the procedure was converted into a penetrating keratoplasty. Posterior lamellar keratoplasty through a sclerocorneal pocket incision is a feasible surgical approach to manage corneal endothelial disorders.

  9. Preliminary Results from the Triple Fission-Ejecta Correlations Trial (TRIFECTA) at ORNL

    Science.gov (United States)

    Peters, William; Smith, M. S.; Galindo-Uribarri, A.; Temanson, E.; Smith, K.; Paulauskas, S. V.; Thornsberry, C.; Jones, K. L.; Grzywacz, R.; Cizewski, J. A.

    2017-09-01

    Despite fission having been studied for almost 80 years, there is a shortage of data on the correlations of multiple fission products needed to benchmark advanced theoretical models of fission. A pioneering experiment underway at ORNL, the Triple Fission-Ejecta Correlations Trial (TRIFECTA), involves the measurement of energy and angular correlations between prompt 252Cf fission neutrons and gamma rays with respect to one fission fragment in time-coincidence. The mass of one fragment is determined, with 4 amu precision, by using 2 micro-channel plate timing detectors and a silicon total-energy detector. Time-coincident data from auxiliary detectors are also recorded: 6 NaI detectors to measure gamma-ray multiplicity, 1 HPGe detector to measure the high-resolution gamma-ray spectrum, and an array of 28 VANDLE modules to measure the neutron spectrum and multiplicity. For the first time, correlations between coincident fragment - gamma - neutron fission products can be studied, as a function of fragment mass. Utilizing certain unique gamma-ray transitions recorded by the HPGe detector, we were able to determine the neutron energy and angular correlations of specific fission fragments. Preliminary results on neutron - neutron angular correlations, gamma-ray vs. neutron multiplicity, and other correlations will be presented, along with plans for future improvements. Work supported in part by the Laboratory Directed Research and Development Program of ORNL, managed by UT-Battelle, LLC, for the U.S. Department of Energy. Done...processed 708 records...16:18:14

  10. Increase in Drosophila melanogaster longevity due to rasayana diet: Preliminary results.

    Science.gov (United States)

    Priyadarshini, S; Ashadevi, J S; Nagarjun, V; Prasanna, K S

    2010-04-01

    We report preliminary results from an ongoing series of experiments on lifespan extension by appropriately modified Ayurvedic rasayanas in animal models. Here data are presented indicating lifespan extensions of 51-55% (up to 70-95% in the pilot experiment) in a standard strain of Drosophila melanogaster (Oregon-K) using a standard rasayana (Ayurvedic herbal formulation for life-extension) suitably adapted for insects. In a first experiment, two groups of 20 unmated D. melanogaster strain Oregon-K kept at 22°C received either rasayana or standard yeast diet; days of death were recorded. Another experiment investigated possible sex differences; equal sized (N = 30) groups of similar males, females, and controls were compared. Life lengths of all controls were in the strain's usual range: in Experiment 1, control life lengths were minimum 40 to maximum 53 days; experimental group figures were 81-91 days; groups were completely separated, experimental group minimum life length being 28 days more than control group maximum life length, i.e., about 2.5 full distribution widths - a sign test for the null hypothesis yields p rasayanas in question increase D. melanogaster strain Oregon-K life length. The complexity of the formulation suggests that multiple mechanisms are involved - worth further investigation.

  11. Data Analysis and Preliminary Results of the Proton Charge Radius Experiment (PRad) at JLab

    Science.gov (United States)

    Xiong, Weizhi; Peng, Chao; PRad Collaboration

    2017-09-01

    In order to investigate the proton radius puzzle, the PRad experiment (E12-11-106) was performed in 2016 in Hall B at Jefferson Lab, with 1.1 and 2.2 GeV unpolarized electron beam on a windowless H2 gas flow target. The experiment aims to extract the electric form factor of the proton in an unprecedented low squared momentum transfer region (Q2 = 2 ×10-4 - 0.06(GeV / c) 2), with a sub-percent precision. The PRad experiment utilizes a non-magnetic calorimetric method with a large acceptance and high resolution calorimeter (HyCal), and two large area, high spatial resolution Gas Electron Multiplier (GEM) detectors. To control the systematic uncertainties, the absolute e - p elastic scattering cross section is normalized to that of the well-known M øller scattering process, which is measured simultaneously within similar kinematics and experimental acceptances. Both the luminosity and the energy independent part of the detector acceptance and efficiency are canceled out in the ratio. In this talk, we will discuss details of the data analysis and present the preliminary physics results from the 2.2 GeV data. This work is supported in part by the U.S. Department of Energy under Contract No. DE-FG02-03ER41231, NSF MRI award PHY-1229153, Thomas Jefferson National Accelerator Facility and Duke University.

  12. Developmentof improved basal friction parameterizations using ISSM: Preliminary results for Greenland's Jakobshavn Ice Stream

    Science.gov (United States)

    Halkides, D. J.; Larour, E.; Morlighem, M.; Seroussi, H.

    2012-04-01

    In ice flow models, the basal friction law links velocity at the ice-bed interface to drag at the glacial base. Accurate ice stream simulation relies on parameterization of this relationship, but basal drag cannot be measured observationally, remaining a key unknown in ice flow modeling. The Ice Sheet System Model (ISSM), developed at the California Institute of Technology's Jet Propulsion Laboratory (JPL) in collaboration with UC Irvine, is a state of the art, finite-element model capable of simulating 3-D transient ice flow on an anisotropic mesh and incorporating data assimilation through use of inverse control methods. As part of a larger development effort to improve simulation/understanding of ice sheet evolution in Greenland and Antarctica, we present preliminary results from ISSM for the sensitivity of Greenland's Jakobshavn ice stream to a range of friction law parameterizations, with model-data comparisons for the surface flow field. This work has implications for ice sheet model development and understanding of ice sheet slippage events. This work was performed at JPL under a contract with the National Aeronautics and Space Administration's Modeling, Analysis and Prediction (MAP) Program.

  13. PRELIMINARY RESULTS OF QUALITY STUDY OF WATER FROM SMALL MICHALICE RESERVOIR ON WIDAWA RIVER

    Directory of Open Access Journals (Sweden)

    Mirosław Wiatkowski

    2014-10-01

    Full Text Available The paper presents an analysis of water quality of the small Michalice reservoir. A preliminary assessment of the reservoir water quality and its usability was made. The quality of water in the reservoir is particularly important as the main functions of the reservoir are agricultural irrigation, recreation and flood protection . The following physico-chemical parameters of the Widawa River were analyzed: NO3 -, NO2 -, NH4 +, PO4 3-, COD, water temperature, pH and electrolytic conductivity. Main descriptive statistical data were presented for the analyzed water quality indicators. The research results indicate that the reservoir contributed to the reduced concentrations of the following water quality indicators: nitrates, nitrites, phosphates, electrolytic conductivity and COD (in the outflowing water – St.3 in comparison to the water flowing into the reservoir – St.1. In the water flowing out of the Psurów reservoir higher values of the remaining indicators were observed if compared with the inflowing water. It was stated, as well, that analised waters are not vulnerable to nitrogen compounds pollution coming from the agricultural sources and are eutrophic. For purpose obtaining of the précised information about condition of Michalice reservoir water purity as well as river Widawa it becomes to continue the hydrological monitoring and water quality studies.

  14. Hippocampal Brain Volume Is Associated with Faster Facial Emotion Identification in Older Adults: Preliminary Results

    Science.gov (United States)

    Szymkowicz, Sarah M.; Persson, Jonas; Lin, Tian; Fischer, Håkan; Ebner, Natalie C.

    2016-01-01

    Quick correct identification of facial emotions is highly relevant for successful social interactions. Research suggests that older, compared to young, adults experience increased difficulty with face and emotion processing skills. While functional neuroimaging studies suggest age differences in neural processing of faces and emotions, evidence about age-associated structural brain changes and their involvement in face and emotion processing is scarce. Using structural magnetic resonance imaging (MRI), this study investigated the extent to which volumes of frontal and temporal brain structures were related to reaction time in accurate identification of facial emotions in 30 young and 30 older adults. Volumetric segmentation was performed using FreeSurfer and gray matter volumes from frontal and temporal regions were extracted. Analysis of covariances (ANCOVAs) models with response time (RT) as the dependent variable and age group and regional volume, and their interaction, as independent variables were conducted, controlling for total intracranial volume (ICV). Results indicated that, in older adults, larger hippocampal volumes were associated with faster correct facial emotion identification. These preliminary observations suggest that greater volume in brain regions associated with face and emotion processing contributes to improved facial emotion identification performance in aging. PMID:27610082

  15. Psychosocial and biochemical interactions in aging: preliminary results from an Italian old sample of "Zincage" project.

    Science.gov (United States)

    Marcellini, F; Giuli, C; Papa, R; Gagliardi, C; Malavolta, M; Mocchegiani, E

    2007-01-01

    The study of the interactions among biological factors and psychosocial conditions is a very innovative field, because data are lacking in the scientific literature. Among biological aspects, zinc is an essential element in the elderly, especially in relation to one of the proteins, such as albumin, involved in zinc transport into the cells. In this study, the aim is the assessment of the interrelationship between albumin value (used as an index of the body zinc status) and some psychosocial dimensions in elderly Italian sample recruited for ZINCAGE project, supported by the European Commission in the "Sixth Framework Programme". Some tests and questionnaires were administered to older people included in the trial: the "life-style questionnaire"; the mini mental state examination (MMSE); the geriatric depression scale (GDS-15 items). On the basis of the Senieur Protocol for gerontological studies, a sample of 291 Italian healthy old subjects has been recruited in Central Italy and divided into 3 age groups: (a) 125 subjects aged from 65 to 74 years, (b) 89 subjects aged from 75 to 84 years, (c) 77 subjects aged >or=85 years (classified like successful old people). No cognitive impairment assessed by MMSE was observed in 67.5% of the sample; 64.0% had GDS score less than 5, indicating no depression, whereas the prevalence of biological albumin deficiency (or=5). These preliminary results showed an interrelationship among serum albumin value and psychosocial aspects in Italian old population, suggesting that low albumin values may be involved in impaired psychological dimensions.

  16. Preliminary results of the International Fusion Materials Irradiation Facility deuteron injector

    Energy Technology Data Exchange (ETDEWEB)

    Gobin, R.; Adroit, G.; Bogard, D.; Bourdelle, G.; Chauvin, N.; Delferriere, O.; Gauthier, Y.; Girardot, P.; Guiho, P.; Harrault, F.; Jannin, J. L.; Loiseau, D.; Mattei, P.; Roger, A.; Sauce, Y.; Senee, F.; Vacher, T. [Commissariat a l' Energie Atomique et aux Energie Alternatives, CEA/Saclay, DSM/IRFU, 91191-Gif/Yvette (France)

    2012-02-15

    In the framework of the IFMIF-EVEDA project (International Fusion Materials Irradiation Facility-Engineering Validation and Engineering Design Activities), CEA/IRFU is in charge of the design, construction, and characterization of the 140 mA continuous deuteron injector, including the source and the low energy beam line. The electron cyclotron resonance ion source which operates at 2.45 GHz is associated with a 4-electrode extraction system in order to minimize beam divergence at the source exit. Krypton gas injection is foreseen in the 2-solenoid low energy beam line. Such Kr injection will allow reaching a high level of space charge compensation in order to improve the beam matching at the radio frequency quadrupole (RFQ) entrance. The injector construction is now completed on the Saclay site and the first plasma and beam production has been produced in May 2011. This installation will be tested with proton and deuteron beams either in pulsed or continuous mode at Saclay before shipping to Japan. In this paper, after a brief description of the installation, the preliminary results obtained with hydrogen gas injection into the plasma chamber will be reported.

  17. PRELIMINARY RESULTS OF EARTHQUAKE-INDUCED BUILDING DAMAGE DETECTION WITH OBJECT-BASED IMAGE CLASSIFICATION

    Directory of Open Access Journals (Sweden)

    A. Sabuncu

    2016-06-01

    Full Text Available Earthquakes are the most destructive natural disasters, which result in massive loss of life, infrastructure damages and financial losses. Earthquake-induced building damage detection is a very important step after earthquakes since earthquake-induced building damage is one of the most critical threats to cities and countries in terms of the area of damage, rate of collapsed buildings, the damage grade near the epicenters and also building damage types for all constructions. Van-Ercis (Turkey earthquake (Mw= 7.1 was occurred on October 23th, 2011; at 10:41 UTC (13:41 local time centered at 38.75 N 43.36 E that places the epicenter about 30 kilometers northern part of the city of Van. It is recorded that, 604 people died and approximately 4000 buildings collapsed or seriously damaged by the earthquake. In this study, high-resolution satellite images of Van-Ercis, acquired by Quickbird-2 (© Digital Globe Inc. after the earthquake, were used to detect the debris areas using an object-based image classification. Two different land surfaces, having homogeneous and heterogeneous land covers, were selected as case study areas. As a first step of the object-based image processing, segmentation was applied with a convenient scale parameter and homogeneity criterion parameters. As a next step, condition based classification was used. In the final step of this preliminary study, outputs were compared with streetview/ortophotos for the verification and evaluation of the classification accuracy.

  18. Integrated Bio-ISRU and Life Support Systems at the Lunar Outpost: Concept and Preliminary Results

    Science.gov (United States)

    Brown, I. I.; Garrison, D. H.; Allen, C. C.; Pickering, K.; Sarkisova, S. A.; Galindo, C., Jr.; Pan, D.; Foraker, E.; Mckay, D. S.

    2009-01-01

    We continue the development of our concept of a biotechnological loop for in-situ resource extraction along with propellant and food production at a future lunar outpost, based on the cultivation of litholytic cyanobacteria (LCB) with lunar regolith (LR) in a geobioreactor energized by sunlight. Our preliminary studies have shown that phototropic cultivation of LCB with simulants of LR in a low-mineralized medium supplemented with CO2 leads to rock dissolution (bioweathering) with the resulting accumulation of Fe, Mg and Al in cyanobacterial cells and in the medium. LCB cultivated with LR simulants produces more O2 than the same organisms cultivated in a high-mineralized medium. The loss of rock mass after bioweathering with LCB suggests the release of O from regolith. Further studies of chemical pathways of released O are required. The bioweathering process is limited by the availability of CO2, N, and P. Since lunar regolith is mainly composed of O, Si, Ca, Al and Mg, we propose to use organic waste to supply a geobioreactor with C, N and P. The recycling of organic waste, including urine, through a geobioreactor will allow for efficient element extraction as well as oxygen and biomass production. The most critical conclusion is that a biological life support system tied to a geobioreactor might be more efficient for supporting an extraterrestrial outpost than a closed environmental system.

  19. SALMONELLA SPP. IN SEVERAL TISSUES AND PIG CARCASSES AND IN SLAUGHTERHOUSES: PRELIMINARY RESULTS

    Directory of Open Access Journals (Sweden)

    A.M. Cosseddu

    2013-02-01

    Full Text Available The aim of the present study was to evaluate the sources of direct and cross-contamination by Salmonella spp. of swine meat at slaughterhouse. The study was carried out in 4 plants of Sardinia, where pigs of different origin (Regional, Nederland, Spain, France were slaughtered. Two-hundred ninetyfour samples were examined for Salmonella spp.: samples of caecal material, tonsils and limphonodes, carcass and liver, from 67 pigs randomly selected, and 21 environmental samples were collected. A selection of strains were submitted to phenotypical identification (API ID32E and serotyping (N.R.C. for Salmonellosis. Salmonella spp. was isolated from the 21,4% of samples, both from pigs and environmental samples. The highest prevalence was observed in limphonodes samples (37,3%, whereas the lowest on the carcasses (10,4%. Eight different serotypes were detected, the more common was S. Derby (67%, followed by S. Livingstone (8% and S. Typhimurium (6,3%. The 8% of the strains were unknown serotype. Our preliminary results confirm the important role of pigs in the diffusion of Salmonella in the slaughterhouses. The recovering of unusual serotypes from liver surfaces and slaughterhouse environments, pointed out the importance of a better Good Slaughtering Practices application by the workers, in order to prevent the possibility of crosscontamination of raw meats.

  20. Upper crustal structure beneath East Java from ambient noise tomography: A preliminary result

    Energy Technology Data Exchange (ETDEWEB)

    Martha, Agustya Adi [Meteorological, Climatological and Geophysical Agency, Jakarta (Indonesia); Graduate Research on Earthquakes and Active Tectonics, Institut Teknologi Bandung, Bandung (Indonesia); Widiyantoro, Sri [Global Geophysics Group, Institut Teknologi Bandung, Bandung (Indonesia); Center for Disaster Mitigation, Institut Teknologi Bandung, Bandung (Indonesia); Cummins, Phil; Saygin, Erdinc [Research School of Earth Sciences, Australian National University, Canberra (Australia); Masturyono [Meteorological, Climatological and Geophysical Agency, Jakarta (Indonesia)

    2015-04-24

    East Java has a fairly complex geological structure. Physiographically East Java can be divided into three zones, i.e. the Southern Mountains zone in the southern part, the Kendeng zone in the middle part, and the Rembang zone in the northern part. Most of the seismic hazards in this region are due to processes in the upper crust. In this study, the Ambient Noise Tomography (ANT) method is used to image the upper crustal structure beneath East Java. We have used seismic waveform data recorded by 8Meteorological, Climatological and Geophysical Agency (BMKG) stationary seismographic stations and 16 portable seismographs installed for 2 to 8 weeks. The data were processed to obtain waveforms fromnoise cross-correlation between pairs of seismographic stations. Our preliminary results indicate that the Kendeng zone, an area of low gravity anomaly, is associated with a low velocity zone. On the other hand, the southern mountain range, which has a high gravity anomaly, is related to a high velocity anomaly as shown by our tomographic images.

  1. Upper crustal structure beneath East Java from ambient noise tomography: A preliminary result

    Science.gov (United States)

    Martha, Agustya Adi; Widiyantoro, Sri; Cummins, Phil; Saygin, Erdinc; Masturyono

    2015-04-01

    East Java has a fairly complex geological structure. Physiographically East Java can be divided into three zones, i.e. the Southern Mountains zone in the southern part, the Kendeng zone in the middle part, and the Rembang zone in the northern part. Most of the seismic hazards in this region are due to processes in the upper crust. In this study, the Ambient Noise Tomography (ANT) method is used to image the upper crustal structure beneath East Java. We have used seismic waveform data recorded by 8Meteorological, Climatological and Geophysical Agency (BMKG) stationary seismographic stations and 16 portable seismographs installed for 2 to 8 weeks. The data were processed to obtain waveforms fromnoise cross-correlation between pairs of seismographic stations. Our preliminary results indicate that the Kendeng zone, an area of low gravity anomaly, is associated with a low velocity zone. On the other hand, the southern mountain range, which has a high gravity anomaly, is related to a high velocity anomaly as shown by our tomographic images.

  2. The Geoengineering Model Intercomparison Project Phase 6 (GeoMIP6: simulation design and preliminary results

    Directory of Open Access Journals (Sweden)

    B. Kravitz

    2015-10-01

    Full Text Available We present a suite of new climate model experiment designs for the Geoengineering Model Intercomparison Project (GeoMIP. This set of experiments, named GeoMIP6 (to be consistent with the Coupled Model Intercomparison Project Phase 6, builds on the previous GeoMIP project simulations, and has been expanded to address several further important topics, including key uncertainties in extreme events, the use of geoengineering as part of a portfolio of responses to climate change, and the relatively new idea of cirrus cloud thinning to allow more longwave radiation to escape to space. We discuss experiment designs, as well as the rationale for those designs, showing preliminary results from individual models when available. We also introduce a new feature, called the GeoMIP Testbed, which provides a platform for simulations that will be performed with a few models and subsequently assessed to determine whether the proposed experiment designs will be adopted as core (Tier 1 GeoMIP experiments. This is meant to encourage various stakeholders to propose new targeted experiments that address their key open science questions, with the goal of making GeoMIP more relevant to a broader set of communities.

  3. Gamma radiation measurement in select sand samples from Camburi beach - Vitoria, Espirito Santo, Brazil: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Barros, Livia F.; Pecequilo, Brigitte R.S.; Aquino, Reginaldo R., E-mail: lfbarros@ipen.b, E-mail: brigitte@ipen.b, E-mail: raquino@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    The variation of natural radioactivity along the surface of the beach sands of Camburi, located in Vitoria, capital of Espirito Santo, southeastern Brazil, was determined from the contents of {sup 226}Ra, {sup 232}Th and {sup 40}K. Eleven collecting points was selected along all the 6 km extension of the Camburi beach. Sand samples collected from all established points on January 2011 were dried and sealed in standard 100 mL polyethylene flasks and measured by high resolution gamma spectrometry after a 4 weeks ingrowth period, in order to allow the secular equilibrium in the {sup 238}U and {sup 232}Th series. The {sup 226}Ra concentration was determined from the weighted average concentrations of {sup 214}Pb and {sup 214}Bi. The {sup 232}Th concentration was determined from the weighted average concentrations of {sup 228}Ac, {sup 212}Pb and {sup 212}Bi and the {sup 40}K from its single gamma transition. Preliminary results show activity concentrations varying from 5 Bq.kg{sup -1} to {sup 222} Bq.kg{sup -1} for {sup 226}Ra and from 14 Bq.kg{sup -1} to 1074 Bq.kg{sup -'}1 for {sup 232}Th, both with the highest values for Camburi South and Central. For {sup 40}K, the activity concentrations ranged from 14 Bq.kg{sup -1} to 179 Bq.kg{sup -1} and the highest values were obtained for Camburi South. (author)

  4. Preliminary Census of ROSAT Bright Sources: Results from ClassX

    Science.gov (United States)

    White, R. L.; Suchkov, A. A.; Hanisch, R. J.; Postman, M.; Donahue, M. E.; McGlynn, T. A.; Winter, E. L.; Corcoran, M. F.; Drake, S. A.; Pence, W. D.; White, N.; Angelini, L.; Genova, F.; Ochsenbein, F.; Fernique, P.; Derriere, S.; Voges, W.

    2002-12-01

    ClassX is being developed as a system for automated classification of X-ray sources within the Virtual Observatory environment. Its core is a network of classifiers ``trained'' using diverse data sets for X-ray sources of known object type and their optical, infrared, radio, etc. counterparts. The network is integrated in the ClassX pipeline with a search engine that queries remote multi-wavelength data repositories, using systems such as CDS VizieR service, to get data (in the VOTable format) for the sources to be classified. In this paper we present a preliminary census from ClassX for earlier unclassified X-ray sources observed with the ROSAT PSPC and compare it with the frequency of object types in samples of previously classified sources. The early results include findings that our sources are dominated by QSOs followed by clusters of galaxies. Previously classified sources are by contrast dominated by stars. Since these star-dominated samples were used to train our classifiers, the predominance of extragalactic sources is all the more striking. We find it encouraging that the ClassX census appear to be quite consistent with expectations based on the analysis of flux differences of previously classified and unclassified sources, while the variations between census versions from different classifiers are rather transparently related to the classifier differences.

  5. Experimental Estimation for Beat-Wave Current Generation in an Unmagnetized Plasma and Preliminary Results

    Science.gov (United States)

    Liu, Fei; Horton, Robert; Hwang, David; Zhu, Ben; Evans, Russell

    2009-11-01

    Beat-wave current generation experiment in a high density compact torus (CT) is being conducted on CTIX using CO2 lasers. Tunability of the CO2 lasers provides many options for the wave-particle interaction experiment at a variety of plasma densities with plasma frequency in THz range. For example strong lines such as 9R(12) and 9R(30) could be chosen for an easily obtainable density of 1.28x10^15cm-3. After restoration, two Lumonics CO2 lasers are expected to produce approximately 100MW output power in a 50ns pulse. The amount of energy transfer from laser to plasma is determined by the laser power intensity, and by the CT density scale length [1]. The desired power density can be achieved by designing a suitable optical focusing system. In addition, the CT density can be matched to the beat-wave frequency by appropriately selecting the plasma operating conditions and timing. Extensive testing of the Marx banks and pre-ionization boards was done under a variety of operating conditions. Other preliminary results and plans for the wave-particle interaction experiment will also be reported. [1] A. N. Kaufman, B. I. Cohen, PRL, 30 1306 (1973)

  6. Anesthesia effect on single local field potentials variability in rat barrel cortex: Preliminary results.

    Science.gov (United States)

    Cecchetto, Claudia; Mahmud, Mufti; Vassanelli, Stefano

    2015-01-01

    The rat barrel cortex is a widely used model of information processing in the somatosensory area, thanks to its precise and easily recognizable organization. However, evoked Local Field Potentials (LFPs) generated in the barrel cortex by repetitive deflections of rat whiskers show large variability in shapes and timings. Moreover, anesthetics can deeply affect the profile of evoked responses. This paper presents preliminary report on the variability and the effect of commonly used anesthetics on these signals. We studied representative signal shape characteristics (e.g., latency and amplitude of events) extracted from evoked responses acquired by means of standard Ag/AgCl electrodes from different cortical layers. As an early result, we found significant difference in the latency of the first principal peak of the responses. Under Tiletamine-Xylazine anesthetic, the responses or events of the evoked LFPs occurred later than the ones recorded while urethane was administered. Furthermore, the distributions of the peak latencies in all cortical layers were narrower in case of Urethane. This behavior should be attributed to the different effects of these two anesthetics on specific synaptic receptors and thus on the processing of neural information and the encoding of sensory input along the cortical pathway.

  7. BRIDGE - Behavioural reaching interfaces during daily antigravity activities through upper limb exoskeleton: Preliminary results.

    Science.gov (United States)

    Gandolla, Marta; Costa, Andrea; Aquilante, Lorenzo; Gfoehler, Margit; Puchinger, Markus; Braghin, Francesco; Pedrocchi, Alessandra

    2017-07-01

    People with neuromuscular diseases such as muscular dystrophy experience a distributed and evolutive weakness in the whole body. Recent technological developments have changed the daily life of disabled people strongly improving the perceived quality of life, mostly concentrating on powered wheelchairs, so to assure autonomous mobility and respiratory assistance, essential for survival. The key concept of the BRIDGE project is to contrast the everyday experience of losing functions by providing them of a system able to exploit the best their own residual capabilities in arm movements so to keep them functional and autonomous as much as possible. BRIDGE is composed by a light, wearable and powered five degrees of freedom upper limb exoskeleton under the direct control of the user through a joystick or gaze control. An inverse kinematic model allows to determine joints position so to track patient desired hand position. BRIDGE prototype has been successfully tested in simulation environment, and by a small group of healthy volunteers. Preliminary results show a good tracking performance of the implemented control scheme. The interaction procedure was easy to understand, and the interaction with the system was successful.

  8. Estimated glomerular filtration rate in a sample of university students. Argentina, 2014-2015. Preliminary results

    Directory of Open Access Journals (Sweden)

    Cecilia Brissón

    2017-04-01

    Full Text Available Introduction: The high global prevalence of Chronic Kidney Disease (CKD and its implications for public health are well recognized. There are few studies related to the values of glomerular filtration rate (GFR and its staging in young people. GFR was estimated by creatinine clearance (CrCl by formulas, totals, by category G of GFR and sex on a sample of Argentine students. Agreement between estimation methods was also evaluated. Methods: Descriptive study of 75 students during the period May 2014-September 2015. GFR was estimated by Cockcroft-Gault (CG, MDRD-4 and CrCl using creatinine not traceable by IDMS and MDRD-4 IDMS and CKD-EPI with traceable creatinine. Results: Mean values and frequencies depending on the estimation method. Moderate to good agreement between CKD-EPI and CG and between CrCl and CGwas found. Conclusions: Although these findings are preliminary and should be confirmed in a larger sample, they help to describe higher GFR stages in a young population and to visualize differences between estimators used.

  9. Evaluating outcomes of palliative photodynamic therapy: instrument development and preliminary results

    Science.gov (United States)

    Goodell, Teresa T.; Bargo, Paulo R.; Jacques, Steven L.

    2002-06-01

    Background: Subjective measures are considered the gold standard in palliative care evaluation, but no studies have evaluated palliative photodynamic therapy (PDT) subjectively. If PDT is to be accepted as a palliative therapy for later-stage obstructing esophageal and lung cancer, evidence of its effectiveness and acceptability to patients must be made known. Study Design/Materials and Methods: This ongoing study's major aim is to evaluate subjective outcomes of PDT in patients with obstructing esophageal and lung cancer. Existing measures of health status, dysphagia and performance status were supplemented with an instrument developed to evaluate PDT symptom relief and side effect burden, the PDT Side Effects Survey (PSES). Results: PDT patients treated with porfimer sodium (Photofrin) and 630-nm light experienced reduced dysphagia grade and stable performance status for at least one month after PDT (N= 10-17), but these effects did not necessarily persist at three months. Fatigue, appetite and quality of life may be the most burdensome issues for these patients. Conclusions: Preliminary data suggest that the PSES is an acceptable and valid tool for measuring subjective outcomes of palliative PDT. This study is the first attempt to systematically evaluate subjective outcomes of palliative PDT. Multi-center outcomes research is needed to draw generalizable conclusions that will establish PDT's effectiveness in actual clinical practice and enhance the wider adoption of PDT as a cancer symptom relief modality.

  10. Preliminary results of pre-stack reverse time migration of teleseismic receiver functions

    Science.gov (United States)

    Jiang, X.; Zhu, L.; Huang, R.; Luo, S.

    2016-12-01

    The pre-stack reverse time migration (RTM) method, with robust anti-interference capability in complex structure of the Earth interior, has been successfully used in active-source seismic imaging for decades. In this study, we tested feasibility of adopting this method in passive-source seismic imaging. The receiver function (RF) technical is considered to be one of the most efficient ways in passive seismology to detect interfaces of subsurface and the common conversion point (CCP) stacking scheme has often been used to image the Moho discontinuity and mantle transition zone. However, the conventional CCP scheme uses 1D layered background velocity model, which can lead to distorted image in cases of dipping or step interfaces. The RTM method, on the other hand, can easily handle velocity structures of strong lateral variation. We first calculated forward wavefield due to an incident plane wave and its reverse-time wavefield using a 6th-order staggered-grid finite-difference method. We then tested the imaging condition by cross-correlating the two wavefields. Various laterally heterogeneous background velocity models were used with dipping and offset interfaces. We compared the images with the input models and those of CCP imaging. Preliminary results shows that the RTM method is promising for imaging subsurface structures using RFs. Application to real data will be presented at the meeting too.

  11. Synaptic Plasticity In Mammalian Gravity Sensors: Preliminary Results From SLS-2

    Science.gov (United States)

    Ross, M. D.; Hargens, Alan R. (Technical Monitor)

    1996-01-01

    Sensory conflict is the prevalent theoretical explanation for space adaptation syndrome. This ultrastructural study tests the hypothesis that peripheral gravity sensors (maculae) play a role. Results were obtained from the medial part of utricular maculae of adult rats exposed to microgravity for 14 days, and from controls. Means and statistical significance of synapse counts were calculated using SUPERANOVA(Trademark) and Scheffe's procedure for post-hoc comparisons. Preliminary findings are from 2 sets of 100 serial sections for each dataset. Synapses were doubled numerically in type II hair cells of utricular maculae collected on day 13 inflight compared to controls (11.4 +/- 7.1 vs. 5.3 +/- 3.8; p synaptic number declined rapidly postflight and became comparable to means of controls. Synapses also increased numerically in type I cells inflight (2.4 +/- 1.6 vs. 1.7 +/- 1.0; p synaptic plasticity into the adult stage. Macular plasticity has clinical implications for balance disorders of peripheral origin.

  12. Danish randomized trial comparing breast-preserving therapy with mastectomy in mammary carcinoma. Preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Blichert-Toft, M.; Brincker, H.; Andersen, J.A.; Andersen, K.W.; Axelsson, C.K.; Mouridsen, H.T.; Dombernowsky, P.; Overgaard, M.; Gadeberg, C.; Knudsen, G.

    1988-01-01

    The present study comprises 847 women operated upon for invasive breast carcinoma at 19 surgical departments and enrolled in protocol DBCG-82TM from January 1983 to November 1987. Among them 662 (78%) were allocated for breast-preserving therapy or mastectomy by randomization, while 185 patients (22%) did not accept randomization. Within the randomized group 6% could not be entered into adjuvant protocols, i.e. subsequent programmes of postoperative therapy and follow-up. This left 619 evaluable patients. In the non-randomized series 26% did not fulfil the demands for entrance into the adjuvant protocols, leaving 136 evaluable patients, 60 of whom had chosen a breast-preserving operation and 76 mastectomy. In the randomized series the patients in the two treatment arms were comparable in age, menopausal status, site of tumour, pathoanatomical diameter of the tumour, number of removed axillary lymph nodes, number of metastatic axillary lymph nodes, and distribution on adjuvant regimens. Ninety per cent of the patients in the randomized group accepted the method offered, whereas 10% declined and wanted the alternate form of operation. The median follow-up period was approximately 1.75 years. The cumulative recurrence rate in the randomized group was 13% and in the non-randomized group 7%. These results are preliminary. Life-table analyses have not so far demonstrated differences in recurrence-free survival either in the randomized or the non-randomized series.

  13. 76 FR 79651 - Stainless Steel Butt-Weld Pipe Fittings From Italy: Preliminary Results of Antidumping Duty...

    Science.gov (United States)

    2011-12-22

    ... International Trade Administration Stainless Steel Butt-Weld Pipe Fittings From Italy: Preliminary Results of... antidumping duty order on stainless steel butt-weld pipe fittings (SSBW pipe fittings) from Italy. The review... results of the review to no later than December 15, 2011. See Stainless Steel Butt-Weld Pipe Fittings From...

  14. Iodine-125 brachytherapy in the management of squamous cell carcinoma of the oral cavity and oropharynx.

    Science.gov (United States)

    Stannard, Clare; Maree, Gerrie; Tovey, Susan; Hunter, Alistair; Wetter, Julie

    2014-01-01

    Brachytherapy is an acknowledged modality for treating head and neck cancers and has moved from low-dose-rate (LDR) to high-dose-rate remote afterloading to reduce staff exposure. Iodine-125 ((125)I) is a low-energy source and can be used for LDR brachytherapy with minimal staff exposure. The results of treating with this isotope at Groote Schuur Hospital, Cape Town, are reported here. (125)I brachytherapy was used to treat 114 tumors from 1994 to 2010. Brachytherapy alone was used for 72 tumors, 39 postsurgery and 33 de novo. A brachytherapy boost together with external beam radiotherapy was used for 42 tumors, eight postsurgery and 34 de novo. Tumors were in the tongue, floor of mouth, soft palate, and tonsil, and mainly T1 or T2 classification. Brachytherapy was administered via an applicator or in plastic tubes implanted into the soft tissues or through the submandibular region. Local control rates of 80.7% at 5 years and 80% at 10 years were comparable to LDR, pulsed-dose-rate, and high-dose-rate results with iridium-192, likewise the 5- and 10-year disease-specific survival rate of 74.3%. Complications of soft tissue ulceration occurred in 21 patients (18.4%) and healed spontaneously in 20 patients. There was no mandibular necrosis. (125)I can be used as the sole treatment or as a boost to external beam radiotherapy, with or without surgery for early mouth cancer. It combines the radiobiological advantages of LDR brachytherapy with minimum staff exposure. It is a flexible system. Local control is excellent with acceptable morbidity, and the treatment time is short. Copyright © 2014 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

  15. Patterns of Use and Short-Term Complications of Breast Brachytherapy in the National Medicare Population From 2008–2009

    Science.gov (United States)

    Presley, Carolyn J.; Soulos, Pamela R.; Herrin, Jeph; Roberts, Kenneth B.; Yu, James B.; Killelea, Brigid; Lesnikoski, Beth-Ann; Long, Jessica B.; Gross, Cary P.

    2012-01-01

    Purpose Brachytherapy has disseminated into clinical practice as an alternative to whole-breast irradiation (WBI) for early-stage breast cancer; however, current national treatment patterns and associated complications remain unknown. Patients and Methods We constructed a national sample of Medicare beneficiaries ages 66 to 94 years who underwent breast-conserving surgery from 2008 to 2009 and were treated with brachytherapy or WBI. We used hospital referral regions (HRRs) to assess national treatment variation and an instrumental variable analysis to compare complication rates between treatment groups, adjusting for patient and clinical characteristics. We compared overall, wound and skin, and deep-tissue and bone complications between brachytherapy and WBI at 1 year of follow-up. Results Of 29,648 women in our sample, 4,671 (15.8%) received brachytherapy. The percent of patients receiving brachytherapy varied substantially across HRRs, ranging from 0% to over 70% (interquartile range, 7.5% to 23.3%). Of women treated with brachytherapy, 34.3% had a complication compared with 27.3% of women undergoing WBI (P brachytherapy (95% CI, 28.6 to 41.9) had a complication compared with 18.4% treated with WBI (95% CI, 15.5 to 21.3; P value for difference, Brachytherapy was associated with a 16.9% higher rate of wound and skin complications compared with WBI (95% CI, 10.0 to 23.9; P Brachytherapy is commonly used among Medicare beneficiaries and varies substantially across regions. After 1 year, wound and skin complications were significantly higher among women receiving brachytherapy compared with those receiving WBI. PMID:23091103

  16. Radiation recall reaction with docetaxel administration after accelerated partial breast irradiation with electronic brachytherapy.

    Science.gov (United States)

    Chen, Sea S; Strauss, Jonathan B; Shah, Anand P; Rao, Ruta D; Bernard, Damien A; Griem, Katherine L

    2009-01-01

    Accelerated partial breast irradiation (APBI) offers several advantages over whole breast irradiation. Electronic brachytherapy may further reduce barriers to breast conserving therapy by making APBI more available. However, its toxicity profile is not well characterized. A 60-year-old woman was treated with APBI using Axxent (Xoft, Sunnyvale, CA) electronic brachytherapy. One month after APBI, a cycle of docetaxel and cyclophosphamide was given. Within 3 weeks, the patient developed an ulcerative radiation recall reaction in the skin overlying the lumpectomy cavity. To investigate this toxicity, the skin dose from electronic brachytherapy was compared with the dose that would have been delivered by an iridium-192 ((192)Ir) source. Additionally, a dose equivalent was estimated by adjusting for the increased relative biologic effectiveness (RBE) of low energy photons generated by the electronic source. Using electronic brachytherapy, the skin dose was 537cGy per fraction compared with 470cGy for an (192)Ir source. Given an RBE for a 40kV source of 1.28 compared with (192)Ir, the equivalent dose at the skin for an electronic source was 687cGy-equivalents, a 46% increase. We present a case of an ulcerative radiation recall reaction in a patient receiving APBI with electronic brachytherapy followed by chemotherapy. Our analysis shows that the use of electronic brachytherapy resulted in the deposition of significantly higher equivalent dose at the skin compared with (192)Ir. These findings suggest that standard guidelines (e.g., surface-to-skin distance) that apply to (192)Ir-based balloon brachytherapy may not be applicable to electronic brachytherapy.

  17. Cost-effectiveness analysis of 3D image-guided brachytherapy compared with 2D brachytherapy in the treatment of locally advanced cervical cancer.

    Science.gov (United States)

    Kim, Hayeon; Rajagopalan, Malolan S; Beriwal, Sushil; Huq, M Saiful; Smith, Kenneth J

    2015-01-01

    Three-dimensional image-guided brachytherapy (IGBT) is a significant advance in locally advanced cervical cancer treatment. However, its cost-effectiveness (C/E) is unknown. We performed a C/E analysis of IGBT compared with conventional (two-dimensional [2D]) brachytherapy in the treatment of locally advanced cervical cancer. A Markov model was constructed to model locally advanced cervical cancer treated with five fractions of high-dose-rate brachytherapy. The model captured clinical parameters, quality of life utility, and treatment costs through the literature review. Costs were 2013 Medicare reimbursement. Strategies were compared using the incremental cost-effectiveness ratio (ICER), and effectiveness was measured in quality-adjusted life-years (QALYs). To account for uncertainty, one-way, two-way, and probabilistic sensitivity analyses were performed. Strategies were evaluated from a payer's perspective with a willingness-to-pay threshold of $50,000/QALY gained. Treatment costs for five fractions of IGBT and 2D brachytherapy were $21,374 and $17,931, respectively. In the base-case analysis, the IGBT strategy costs $3003 more than 2D brachytherapy while gaining 0.16 QALYs, resulting in an ICER of $18,634 per QALY gained. In one-way sensitivity analyses, results were most sensitive to variation of treatment costs, but the ICER remained brachytherapy. These findings were robust to variation of parameter values supporting the routine use of IGBT in locally advanced cervical cancer. Copyright © 2015 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

  18. Brain connectivity study of brain tumor patients using MR-PET data: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Mendes, Ana Carina [Institute of Biophysics and Biomedical Engineering, Faculty of Sciences of the University of Lisbon (Portugal); Ribeiro, Andre Santos [Institute of Biophysics and Biomedical Engineering, Faculty of Sciences of the University of Lisbon (Portugal); Centre for Neuropsychopharmacology, Division of Brain Sciences, Department of Medicine, Imperial College London, London (United Kingdom); Oros-Peusquens, Ana Maria; Langen, Karl Josef; Shah, Jon [Institute of Neuroscience and Medicine - 4, Forschungszentrum Juelich (Germany); Ferreira, Hugo Alexandre [Institute of Biophysics and Biomedical Engineering, Faculty of Sciences of the University of Lisbon (Portugal)

    2015-05-18

    Brain activity results from anatomical and functional connections that can be disrupted or altered due to trauma or lesion. This work presents a first approach on the study of whole-brain connectivity of brain tumor patients using the Multimodal Imaging Brain Connectivity (MIBCA) toolbox. Two patients with glioblastoma lesions located in the left hemisphere (one in the motor cortex and the other in the temporal lobe) underwent simultaneous MRI and dynamic PET scans using a 3T MRI scanner with a BrainPET insert. The following data was acquired: T1-w MPRAGE (1x1x1mm{sup 3}), DTI (dir=30, b=0,800s/mm2, 2x2x2mm{sup 3}), and dynamic 18F-FET PET. The MIBCA toolbox was used to automatically pre-process MRI-PET data and to derive imaging and connectivity metrics from the multimodal data. Computed metrics included: cortical thickness from T1-w data; mean diffusivity (MD), fractional anisotropy (FA), node degree, clustering coefficient and pairwise ROI fibre tracking (structural connectivity) from DTI data; and standardized uptake value (SUV) from PET data. For all the metrics, the differences between left and right hemispherical structures were obtained, followed by a 25% threshold (except for SUV thresholded at 15%). Data was visualized in a connectogram, and both structural connectivity and metrics were studied in regions surrounding lesions. Preliminary results showed increased SUV values in regions surrounding the tumor for both patients. Patients also showed changes in structural connectivity involving these regions and also other more spatially distant regions such as the putamen and the pallidum, including decreased number of fibers between the subcortical structures themselves and with frontal regions. These findings suggest that the presence of a tumor may alter both local and more distant structural connections. Presently, a larger patient sample is being studied along with the inclusion of a control group to test the consistency of the findings.

  19. Preliminary results of receiver function analyses at three sites across the Bransfield Strait, Antarctica

    Science.gov (United States)

    Martínez Arévalo, C.; Mancilla, F.; Almendros, J.; Aznarte, J. L.; Alguacil, G.

    2009-04-01

    In February 2008, in the framework of the International Polar Year 2008-2009 under grant POL2006-08663 of the spanish Ministry of Education, we deployed three broadband seismometers at points forming a N-S profile across the Bransfield Strait, Antarctica, in the region between the South Shetland Islands and the Antarctic Peninsula. This region is very interesting from a tectonic point of view, due to the opening of the rift of the Bransfield and the presence of the South Shetland microplate. For logistic reasons, our instruments where located in the vicinity of the Antarctic bases Juan Carlos I (Livingston Island), Gabriel de Castilla (Deception Island), and Primavera (Antarctic Peninsula). Each seismic station consisted of a broad-band, three-component electrolitic seismometer equiped with a 24-bit data acquisition system. The energy was provided by wind generators and solar panels connected to a battery bank, a combination that has been able to provide enough power at all sites, even during the Antarctic winter. All components were designed to function under the extreme conditions of the Antarctic weather. The main objective of this experiment was to use receiver function techniques on teleseism data to investigate the structure of the crust under the sites, in order to compare with other studies and shed light on the structure and tectonics of the region. During this past year, we have recorded several tens of teleseisms at distances appropriate for receiver function analyses. Preliminary results will add information on critical issues regarding the structure of the Bransfield Strait region. Although the Earth models obtained will contain extra information, we are specially interested in the determination of the depth of the Moho at each site, a controversial point in this area. These results will be compared with estimates obtained by different techniques. We are also interested in the determination of the vertical extent of the magma chamber recently imaged by

  20. Preliminary results from a detritiation facility dedicated to soft housekeeping waste

    Energy Technology Data Exchange (ETDEWEB)

    Lefebvre, X., E-mail: xavier.lefebvre@cea.fr [JET-EFDA, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); CEA, DEN, Cadarache DTN/STPA/LIPC, F-13108 Saint-Paul-lez-Durance (France); Trabuc, P.; Liger, K.; Perrais, C. [JET-EFDA, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); CEA, DEN, Cadarache DTN/STPA/LIPC, F-13108 Saint-Paul-lez-Durance (France); Tosti, S.; Borgognoni, F.; Santucci, A. [JET-EFDA, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Associazione ENEA-Euratom sulla Fusione, C.R. ENEA Frascati, Via E. Fermi 45, I-00044 Frascati, RM (Italy)

    2012-08-15

    Highlights: Black-Right-Pointing-Pointer The results of the first detritiation campaign of soft housekeeping are presented. Black-Right-Pointing-Pointer 120 to 150 Degree-Sign C increasing temperature reveals a strong rise of the detritiation yield. Black-Right-Pointing-Pointer Using Ar-2%O{sub 2} declassifies the sample from ILW to LLW (UK) in 18 h. Black-Right-Pointing-Pointer Carrier gas - H{sub 2} explosive risk is assessed before membrane reactor implementation. Black-Right-Pointing-Pointer The optimized conditions are Ar-2%O{sub 2} at 150 Degree-Sign C. - Abstract: Nuclear waste management has to be taken into account for fusion machine in tritium experimentations. Soft housekeeping waste is produced during both operating and dismantling phases and is contaminated by tritium under reduced (HT) and oxidized (HTO) forms. At CEA Cadarache, a lab-scaled facility has been built for soft housekeeping detritiation. The tritiated gas exhausted from the process described above is foreseen to be treated by a tubular Pd-Ag membrane reactor, for gaseous tritium recovery. Since this membrane reactor uses hydrogen as swamping gas the compatibility toward explosive hazard has to be taken into account. Then, this work presents a double objective. A first study is presented in order to identify the best conditions for the declassification of soft housekeeping waste, without tritium recovery. Experiments carried out at 120 Degree-Sign C are not efficient enough and do not allow one to choose the most efficient carrier gas. Some other tests are being currently performed at higher temperatures (150 Degree-Sign C). Moreover, due to safety issues, the use of air has to be avoided during membrane reactor implementation phase. Preliminary results obtained with hydrogen hazard-free carrier gases are also presented.

  1. Blau Syndrome-Associated Uveitis: Preliminary Results From an International Prospective Interventional Case Series.

    Science.gov (United States)

    Sarens, Inge L; Casteels, Ingele; Anton, Jordi; Bader-Meunier, Brigitte; Brissaud, Philippe; Chédeville, Gaelle; Cimaz, Rolando; Dick, Andrew D; Espada, Graciella; Fernandez-Martin, Jorge; Guly, Catherine M; Hachulla, Eric; Harjacek, Miroslav; Khubchandani, Raju; Mackensen, Friederike; Merino, Rosa; Modesto, Consuelo; Naranjo, Antonio; Oliveira-Knupp, Sheila; Özen, Seza; Pajot, Christine; Ramanan, Athimalaipet V; Russo, Ricardo; Susic, Gordana; Thatayatikom, Akaluck; Thomée, Caroline; Vastert, Sebastiaan; Bertin, John; Arostegui, Juan I; Rose, Carlos D; Wouters, Carine H

    2017-09-06

    Provide baseline and preliminary follow-up results in a 5-year longitudinal study of Blau syndrome. Multicenter, prospective interventional case series. Baseline data from 50 patients from 25 centers worldwide, and follow-up data for patients followed 1, 2, or 3 years at the end of study enrollment. Ophthalmic data were collected at baseline and yearly visits by means of a standardized collection form. Median age at onset of eye disease was 60 months and duration of eye disease at baseline 145 months. At baseline 38 patients (78%) had uveitis, which was bilateral in 37 (97%). Eight patients (21%) had moderate to severe visual impairment. Panuveitis was found in 38 eyes (51%), with characteristic multifocal choroidal infiltrates in 29 eyes (39%). Optic disc pallor in 9 eyes (12%) and peripapillary nodules in 9 eyes (12%) were the commonest signs of optic nerve involvement. Active anterior chamber inflammation was noted in 30 eyes (40%) at baseline and in 16 (34%), 17 (57%), and 11 (61%) eyes at 1, 2, and 3 years, respectively. Panuveitis was associated with longer disease duration. At baseline, 56 eyes (75%) were on topical corticosteroids. Twenty-six patients (68%) received a combination of systemic corticosteroids and immunomodulatory therapy. Blau uveitis is characterized by progressive panuveitis with multifocal choroiditis, resulting in severe ocular morbidity despite continuous systemic and local immunomodulatory therapy. The frequency and severity of Blau uveitis highlight the need for close ophthalmologic surveillance as well as a search for more effective therapies. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Preliminary Results of BTDF Calibration of Transmissive Solar Diffusers for Remote Sensing

    Science.gov (United States)

    Georgiev, Georgi T.; Butler, James J.; Thome, Kurt; Cooksey, Catherine; Ding, Leibo

    2016-01-01

    Satellite instruments operating in the reflected solar wavelength region require accurate and precise determination of the optical properties of their diffusers used in pre-flight and post-flight calibrations. The majority of recent and current space instruments use reflective diffusers. As a result, numerous Bidirectional Reflectance Distribution Function (BRDF) calibration comparisons have been conducted between the National Institute of Standards and Technology (NIST) and other industry and university-based metrology laboratories. However, based on literature searches and communications with NIST and other laboratories, no Bidirectional Transmittance Distribution Function (BTDF) measurement comparisons have been conducted between National Measurement Laboratories (NMLs) and other metrology laboratories. On the other hand, there is a growing interest in the use of transmissive diffusers in the calibration of satellite, air-borne, and ground-based remote sensing instruments. Current remote sensing instruments employing transmissive diffusers include the Ozone Mapping and Profiler Suite instrument (OMPS) Limb instrument on the Suomi-National Polar-orbiting Partnership (S-NPP) platform,, the Geostationary Ocean Color Imager (GOCI) on the Korea Aerospace Research Institute's (KARI) Communication, Ocean, and Meteorological Satellite (COMS), the Ozone Monitoring Instrument (OMI) on NASA's Earth Observing System (EOS) Aura platform, the Tropospheric Emissions: Monitoring of Pollution (TEMPO) instrument and the Geostationary Environmental Monitoring Spectrometer (GEMS).. This ensemble of instruments requires validated BTDF measurements of their on-board transmissive diffusers from the ultraviolet through the near infrared. This paper presents the preliminary results of a BTDF comparison between the NASA Diffuser Calibration Laboratory (DCL) and NIST on quartz and thin Spectralon samples.

  3. Hand Robotics Rehabilitation: Feasibility and Preliminary Results of a Robotic Treatment in Patients with Hemiparesis

    Directory of Open Access Journals (Sweden)

    Patrizio Sale

    2012-01-01

    Full Text Available Background. No strongly clinical evidence about the use of hand robot-assisted therapy in stroke patients was demonstrated. This preliminary observer study was aimed at evaluating the efficacy of intensive robot-assisted therapy in hand function recovery, in the early phase after a stroke onset. Methods. Seven acute ischemic stroke patients at their first-ever stroke were enrolled. Treatment was performed using Amadeo robotic system (Tyromotion GmbH Graz, Austria. Each participant received, in addition to inpatients standard rehabilitative treatment, 20 sessions of robotic treatment for 4 consecutive weeks (5 days/week. Each session lasted for 40 minutes. The exercises were carried out as follows: passive modality (5 minutes, passive/plus modality (5 minutes, assisted therapy (10 minutes, and balloon (10 minutes. The following impairment and functional evaluations, Fugl-Meyer Scale (FM, Medical Research Council Scale for Muscle Strength (hand flexor and extensor muscles (MRC, Motricity Index (MI, and modified Ashworth Scale for wrist and hand muscles (AS, were performed at the beginning (T0, after 10 sessions (T1, and at the end of the treatment (T2. The strength hand flexion and extension performed by Robot were assessed at T0 and T2. The Barthel Index and COMP (performance and satisfaction subscale were assessed at T0 and T2. Results. Clinical improvements were found in all patients. No dropouts were recorded during the treatment and all subjects fulfilled the protocol. Evidence of a significant improvement was demonstrated by the Friedman test for the MRC (P<0.0123. Evidence of an improvement was demonstrated for AS, FM, and MI. Conclusions. This original rehabilitation treatment could contribute to increase the hand motor recovery in acute stroke patients. The simplicity of the treatment, the lack of side effects, and the first positive results in acute stroke patients support the recommendations to extend the clinical trial of this

  4. Increase in Drosophila melanogaster longevity due to rasayana diet: Preliminary results

    Directory of Open Access Journals (Sweden)

    S Priyadarshini

    2010-01-01

    Full Text Available We report preliminary results from an ongoing series of experiments on lifespan extension by appropriately modified Ayurvedic rasayanas in animal models. Here data are presented indicating lifespan extensions of 51-55% (up to 70-95% in the pilot experiment in a standard strain of Drosophila melanogaster (Oregon-K using a standard rasayana (Ayurvedic herbal formulation for life-extension suitably adapted for insects. In a first experiment, two groups of 20 unmated D. melanogaster strain Oregon-K kept at 22oC received either rasayana or standard yeast diet; days of death were recorded. Another experiment investigated possible sex differences; equal sized (N = 30 groups of similar males, females, and controls were compared. Life lengths of all controls were in the strain′s usual range: in Experiment 1, control life lengths were minimum 40 to maximum 53 days; experimental group figures were 81-91 days; groups were completely separated, experimental group minimum life length being 28 days more than control group maximum life length, i.e., about 2.5 full distribution widths - a sign test for the null hypothesis yields p < 2 -20 , i.e., 10 -6 as maximum p. Experiment 2 found no differences between life lengths of males and females; but the maximum life length of 30 controls (60 days in males and 66 days in females was once again far shorter than the minimum life length of the 60 in the two experimental groups, strengthening the findings of Experiment 1. Despite group sizes being relatively small, results are conclusive: the rasayanas in question increase D. melanogaster strain Oregon-K life length. The complexity of the formulation suggests that multiple mechanisms are involved - worth further investigation.

  5. The role of apparent diffusion coefficient values in detecting testicular intraepithelial neoplasia: Preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Tsili, Athina C., E-mail: a_tsili@yahoo.gr [Department of Radiology, Medical School, University of Ioannina, 45110 Ioannina (Greece); Ntorkou, Alexandra, E-mail: alexdorkou@yahoo.com [Department of Radiology, Medical School, University of Ioannina, 45110 Ioannina (Greece); Baltogiannis, Dimitrios, E-mail: Greece.dbaltog@cc.uoi.gr [Department of Urology, Medical School, University of Ioannina, 45110 Ioannina (Greece); Goussia, Anna, E-mail: agoussia@uoi.gr [Department of Pathology, Medical School, University of Ioannina, 45110 Ioannina (Greece); Astrakas, Loukas G., E-mail: astrakas@uoi.gr [Department of Medical Physics, Medical School, University of Ioannina, 45110 Ioannina (Greece); Malamou-Mitsi, Vasiliki, E-mail: vmalamou@cc.uoi.gr [Department of Pathology, Medical School, University of Ioannina, 45110 Ioannina (Greece); Sofikitis, Nikolaos, E-mail: akrosnin@hotmail.com [Department of Urology, Medical School, University of Ioannina, 45110 Ioannina (Greece); Argyropoulou, Maria I., E-mail: margyrop@cc.uoi.gr [Department of Radiology, Medical School, University of Ioannina, 45110 Ioannina (Greece)

    2015-05-15

    Highlights: • ADC values proved useful in the discrimination between TGCNs and normal testis. • Testicular intraepithelial neoplasia represents the precursor of most TGCNs. • ADC values cannot be used to detect testicular intraepithelial neoplasia. - Abstract: Introduction: The aim of this study is to improve detection of testicular intraepithelial neoplasia (TIN) by measurement of apparent diffusion coefficient (ADC) values. Materials and methods: Fifty-six MRI examinations of the scrotum, including 26 histologically proven testicular germ cell neoplasms were retrospectively evaluated. DWI was performed using a single shot, multi-slice spin-echo planar diffusion pulse sequence and b-values of 0 and 900 s mm{sup −2}. ADC measurements were classified into three groups according to their location: group 1 (n = 19), non-tumoral part, adjacent to testicular carcinoma, where the possible location of TIN was; group 2 (n = 26), testicular carcinoma; and group 3 (n = 60), normal testicular parenchyma. Analysis of variance (ANOVA) followed by post hoc analysis (Dunnett T3) was used for statistical purposes. Results: The mean ± s.d. of ADC values (×10{sup −3} mm{sup 2}/s) of different groups were: group 1, 1.08 ± 0.20; group 2, 0.72 ± 0.27; and group 3, 1.11 ± 0.14. ANOVA revealed differences of mean ADC between groups (F = 38.859, P < 0.001). Post hoc analysis showed differences between groups 2 and 3 (P < 0.001), groups 2 and 1 (P < 0.001), but not between groups 3 and 1 (P = 0.87). Conclusions: Based on our preliminary results, ADC values do not provide a reliable differentiation between TIN and testicular carcinoma or normal testicular parenchyma.

  6. Liquid ventilator for ultrafast hypothermia induction in juvenile lambs: Preliminary results.

    Science.gov (United States)

    Nadeau, Mathieu; Sage, Michaël; Kohlhauer, Matthias; Robert, Raymond; Vandamne, Jonathan; Mousseau, Julien; Tissier, Renaud; Praud, Jean-Paul; Walti, Hervé; Micheau, Philippe

    2015-08-01

    Total liquid ventilation (TLV) is an emerging mechanical ventilation technique. In this technique, the lungs are filled with liquid perfluorocarbons (PFC) and a liquid ventilator assures ventilation by periodically renewing a volume of oxygenated, CO2 freed and temperature controlled PFC. A huge difference between conventional mechanical ventilation and TLV relates to the fact that PFCs are about 1500 times denser than air. Thus, the PFCs filled lungs turn into an efficient heat exchanger with the circulating blood. One of the most appealing utilization of the lungs as a heat exchanger in TLV is for ultrafast induction of mild therapeutic hypothermia (MTH) for neuroprotection and cardioprotection after ischemia-reperfusion injuries. This study aimed to perform ultrafast MTH induction by TLV in animals up to 25 kg, then perform a fast post-hypothermic rewarming while maintaining proper ventilation. A thermal model of the lamb and liquid ventilator was developed to predict the dynamic and the control strategy to adopt for MTH induction. Two juvenile lambs were instrumented with temperature sensors in the femoral artery, pulmonary artery, oesophagus, right eardrum and rectum. After stabilization in conventional mechanical ventilation, TLV was initiated with ultrafast MTH induction, followed by posthypothermic rewarming. Preliminary results in the two juvenile lambs reveal that the liquid ventilator Inolivent-6.0 can induce MTH by TLV in less than 2.5 min for systemic arterial blood and in less than 10 min for venous return, esophagus and eardrum. Rectal temperature reached MTH in respectively 19.4 and 17.0 min for both lambs. Experimental results were consistent with the model predictions. Moreover, blood gas analysis exhibited that the gas exchange in the lungs was maintained adequately for the entire experiments.

  7. [Intratympanic gentamycin in association with human fibrin glue in the treatment of Meniere's disease: preliminary results].

    Science.gov (United States)

    Casani, A P; Dallan, I; Sellari-Franceschini, S; Nuti, D

    2002-08-01

    The treatment of Menierè's disease (Md) with intratympanic gentamicin has rapidly become one of the most widespread alternatives to surgery in this disorder. Numerous studies, employing different protocols, have reported the use of this antibiotic in the treatment of disabling forms of Md, with success rates in the control of vestibular symptoms varying from 73 to 100%, associated with a rate of hearing complications varying from 0 to 75%. We have reported the results of a preliminary experience carried out in 10 patients affected by monolateral Md who were managed with ablation treatment effected with a mixture of gentamicin and human fibrin glue. Upon follow-up examination after one year, all of the patients presented a marked reduction in vestibular reflectivity on the side treated. The vertigo score was zero in all of the patients, showing that the vertigo symptoms were entirely under control. When patients were asked to rate their disability, vertigo was assessed as completely under control in 7 patients and substantially under control in the remaining 3. None of the patients presented any loss of hearing. On the basis of this experience, we propose a standardized protocol which, using an extremely low overall dose of gentamicin, enables elevated success rates to be obtained with the lowest possible number of injections, thus minimizing the risks to hearing. Intratympanic gentamicin associated with a fibrin carrier in Md appears to enable a standardized dose of the drug to be employed, resulting in a decided reduction in the number of administrations and in the overall dose of the drug applied. This makes it possible, with equal benefits in vertigo control, to significantly minimize any hearing loss.

  8. [Preliminary results concerning summer-time denitrification in the Jiulong River Estuary].

    Science.gov (United States)

    Chen, Neng-Wang; Wu, Jie-Zhong; Hong, Hua-Sheng

    2011-11-01

    Denitrification is an important process mitigating nitrogen (N) pollution in aquatic systems. Water samples in 13 sites throughout the Jiulong River Estuary were collected in July, 2010 in a preliminary investigation of the denitrification rate in this area. As end-products of denitrification, dissolved N2 was measured by determining N2 : Ar ratios using MIMS (HPR-40), while the concentration of nitrous oxide (N2O) dissolved in water was determined by Purge and Trap-Gas Chromatography. The results showed significant spatial variance of net increase of dissolved N2 (ranging between - 9.9 and 66.8 micromol x L(-1)) and N2O (ranging between 4.3 and 31.5 nmol x L(-1)) in the Jiulong River Estuary. The net increase of dissolved N2 and N2O declined gradually from river sites to sea sites. Dissolved N2O was supersaturated by 170%-562%. The air-water fluxes of N2 ranged between -2.9 and 53.2 mmol x (m2 x d) (-1), and N2O between 5.2 and 23.9 micromol x (m2 x d)(-1). The N2O yield shared only 0.03% - 1.2% (average 0.25%) of total N air-water flux. The results suggested that water temperature and nutrient (N and P) were the key factors influencing denitrification. The denitrification rate is controlled by nitrate level at fresh-water sites with salinity mixing.

  9. The Preliminary Results of GMSTech: A Software Development for Microseismic Characterization

    Science.gov (United States)

    Rohaman, Maman; Suhendi, Cahli; Verdhora Ry, Rexha; Sugiartono Prabowo, Billy; Widiyantoro, Sri; Nugraha, Andri Dian; Yudistira, Tedi; Mujihardi, Bambang

    2017-04-01

    The processing of microseismic data requires reliable software for imaging the condition of subsurface related to occurring microseismicity. In general, the currently available software is only specific for certain processing module and developed by the different developer. However, the software with integrated processing modules will give a better value because the users can use it easier and faster. We developed GMSTech (Ganesha Microseismic Technology), a C# language-based standing-alone software consisting several modules for processing of microseismic data. Its function is to solve a non-linear inverse problem and imaging the subsurface. C# library is supported by ILNumerics to reduce time consumption and give good visualization. In this preliminary result, we will present four developed modules: (1) hypocenter determination, (2) moment magnitude calculation, and (3) 3D seismic tomography. In the first module, we provide four methods for locating the microseismic events that can be chosen by a user independently: simulated annealing method, guided grid-search method, Geiger’s method, and joint hypocenter determination (JHD). The second module can be used for calculating moment magnitude using Brune method and to estimate the released energy of the event. At last, we also provided the module of 3-D seismic tomography for imaging the velocity structures based on delay time tomography. We demonstrated the software using both a synthetic data and a real data from a certain geothermal field in Indonesia. The results for all modules are reliable and remarkable, reviewed statistically by RMS error. We will keep examining the software using another set of data and developing further modules of processing.

  10. Gonioscopy-assisted transluminal trabeculotomy, ab interno trabeculotomy: technique report and preliminary results.

    Science.gov (United States)

    Grover, Davinder S; Godfrey, David G; Smith, Oluwatosin; Feuer, William J; Montes de Oca, Ildamaris; Fellman, Ronald L

    2014-04-01

    To introduce a minimally invasive, ab interno approach to a circumferential 360-degree trabeculotomy and to report the preliminary results. Retrospective, noncomparative cases series. Eighty-five eyes of 85 consecutive patients who sought treatment at Glaucoma Associates of Texas with uncontrolled open-angle glaucoma and underwent gonioscopy-assisted transluminal trabeculotomy (GATT) for whom there was at least 6 months of follow-up data. Retrospective chart review of patients who underwent GATT by 4 of the authors (D.S.G., D.G.G., O.S., R.L.F.) between October 2011 and October 2012. The surgery was performed in adults with various open-angle glaucomas. Intraocular pressure (IOP), glaucoma medications, visual acuity, and intraoperative as well as postoperative complications. Eighty-five patients with an age range of 24 to 88 years underwent GATT with at least 6 months of follow-up. In 57 patients with primary open-angle glaucoma, the IOP decreased by 7.7 mmHg (standard deviation [SD], 6.2 mm Hg; 30.0% [SD, 22.7%]) with an average decrease in glaucoma medications of 0.9 (SD, 1.3) at 6 months. In this group, the IOP decreased by 11.1 mmHg (SD, 6.1 mmHg; 39.8% [SD, 16.0%]) with 1.1 fewer glaucoma medications at 12 months. In the secondary glaucoma group of 28 patients, IOP decreased by 17.2 mmHg (SD, 10.8 mmHg; 52.7% [SD, 15.8%]) with an average of 2.2 fewer glaucoma medications at 6 months. In this group, the IOP decreased by 19.9 mmHg (SD, 10.2 mmHg; 56.8% [SD, 17.4%]) with an average of 1.9 fewer medications (SD, 2.1) at 12 months. Treatment was considered to have failed in 9% (8/85) of patients because of the need for further glaucoma surgery. The cumulative proportion of failure at 1 year ranged from 0.1 to 0.32, depending on the group. Lens status or concurrent cataract surgery did not have a statistically significant effect on IOP in eyes that underwent GATT at either 6 or 12 months (P > 0.35). The most common complication was transient hyphema, seen in

  11. Prospective evaluation of patient satisfaction after the use of brachytherapy specific educational materials for cervical cancer.

    Science.gov (United States)

    Rash, Dominique; Hess, Clayton; Lentz, Susan; Tait, Lauren; Michaud, Anthony; Mayadev, Jyoti

    2016-01-01

    Cervical cancer patients are faced with an enormous amount of medical information in a complex oncology field with sophisticated treatments including brachytherapy. We investigated the use of enhanced vs. standard brachytherapy-specific educational materials on patient-reported satisfaction during the informed consent process for intracavitary high-dose-rate brachytherapy. A single-institution, prospective, randomized trial was performed to study patient-reported satisfaction with novel educational materials for high-dose-rate brachytherapy in women undergoing definitive radiation for cervical cancer. Fourteen women receiving informed consent with a customized educational booklet were randomized between no further intervention and take-home educational materials. The weighted average for 10 of 11 survey questions was higher in the intervention arm but ranged between 4 (agree) and 5 (strongly agree) for all questions in both arms. The mean weighted patient satisfaction scores ± standard deviations in the control arm and the intervention arms were 54.3 ± 6.4 and 57.5 ± 2.7, respectively (p = 0.26). Knowledge acquisition is presumed to be part of the coping process for women facing increased stress during a cancer diagnosis. A brachytherapy-specific, visual, patient-educational booklet and take-home materials used to supplement the informed consent process for high-dose-rate brachytherapy resulted in high levels of patient-reported satisfaction among women treated with cervical cancer. Published by Elsevier Inc.

  12. Ruthenium-106 plaque brachytherapy for uveal melanoma: Factors associated with local tumor recurrence

    Science.gov (United States)

    Barker, Christopher A.; Francis, Jasmine H.; Cohen, Gil’ad N.; Marr, Brian P.; Wolden, Suzanne L.; McCormick, Beryl; Abramson, David H.

    2015-01-01

    PURPOSE Plaque brachytherapy is a common form of treatment for uveal melanoma, and the Collaborative Ocular Melanoma Study (COMS) employed I-125. Recently, Ru-106 has been reintroduced for plaque brachytherapy in the United States. We reviewed our experience treating uveal melanoma with Ru-106 plaque brachytherapy using COMS planning techniques, hypothesizing we would observe similar outcomes to those in the COMS. METHODS AND MATERIALS Medical records of patients undergoing Ru-106 plaque brachytherapy were reviewed retrospectively. Patient, tumor, and treatment characteristics were recorded. Outcomes including visual acuity, local tumor recurrence, salvage treatment, metastasis and survival were recorded. Cox regression analyses were used to determine factors associated with local tumor recurrence and enucleation. RESULTS Twenty-eight patients were studied. Median age was 60 and 50% were men. Median tumor base diameter and height were 9.4 and 2.6 mm. Ophthalmic complications were rare. Local tumor recurrence and enucleation occurred in 13 and 4 patients, respectively. Local tumor recurrence was associated with low visual acuity in the tumor-bearing eye, posterior tumors, small plaque size, and difference in plaque-tumor diameter brachytherapy using COMS planning techniques, we found a greater than expected rate of local tumor recurrence. Planning Ru-106 plaque brachytherapy should be done carefully at centers that have previously used COMS protocols and I-125. PMID:24880583

  13. Afterloading: The Technique That Rescued Brachytherapy

    Energy Technology Data Exchange (ETDEWEB)

    Aronowitz, Jesse N., E-mail: jesse.aronowitz@umassmemorial.org

    2015-07-01

    Although brachytherapy had been established as a highly effective modality for the treatment of cancer, its application was threatened by mid-20th century due to appreciation of the radiation hazard to health care workers. This review examines how the introduction of afterloading eliminated exposure and ushered in a brachytherapy renaissance.

  14. Intraoperative HDR Brachytherapy: Present and Future

    NARCIS (Netherlands)

    I.-K.K. Kolkman-Deurloo (Inger-Karina)

    2007-01-01

    textabstractRadiotherapy is one of the most effective modalities in cancer treatment, and can be applied either by external beam radiotherapy or by brachytherapy. Brachytherapy is a treatment modality in which tumors are irradiated by positioning radioactive sources very close to or in the tumor

  15. Low Noise Results From IMS Site Surveys: A Preliminary New High-Frequency Low Noise Model

    Science.gov (United States)

    Ebeling, C.; Astiz, L.; Starovoit, Y.; Tavener, N.; Perez, G.; Given, H. K.; Barrientos, S.; Yamamoto, M.; Hfaiedh, M.; Stewart, R.; Estabrook, C.

    2002-12-01

    Zimbabwe (Archaean granite). Based on a composite of the results from these five surveys, we propose a preliminary IMS Low-Noise Model (pIMS-LNM) consisting of a revision downward of Peterson's NLNM in the passband from 0.1 to about 0.7 s and an extension of Peterson's NLNM above 0.1 to 0.07 s. As these low noise results are derived from data recorded at temporary installations, improved resolution of this model will be possible when data from final installations become available. Preliminary International Monitoring System Low Noise Model (pIMS-LNM) for periods from 0.07 to 0.70 s. Decibels are relative to ground acceleration ((m/s2)2/Hz). Values presented in (Period, dB) format. Figure in bold is from Peterson's NLNM. [(0.07,-167.0),(0.08,-168.0),(0.09,-169.0),(0.10,-169.5), (0.11,-170.5),(0.13,-171.0),(0.14,-171.5),(0.17,-172.0), (0.20,-1 72.5),(0.25,-173.0),(0.30,-173.5),(0.40,-173.0), (0.50,-172.0),(0.60,-171.0),(0.70,-170.0),(0.80,-169.2)] Reference Peterson, J., 1993. Observations and Modeling of Seismic Background Noise, U.S. Geological Survey Open-File Report 93-322, 47 p.

  16. Development of volume equations using data obtained by upper stem dendrometry with Monte Carlo integration: preliminary results for eastern redcedar

    Science.gov (United States)

    Thomas B. Lynch; Rodney E. Will; Rider Reynolds

    2013-01-01

    Preliminary results are given for development of an eastern redcedar (Juniperus virginiana) cubic-volume equation based on measurements of redcedar sample tree stem volume using dendrometry with Monte Carlo integration. Monte Carlo integration techniques can be used to provide unbiased estimates of stem cubic-foot volume based on upper stem diameter...

  17. 77 FR 65361 - Folding Gift Boxes From the People's Republic of China: Preliminary Results of the Second Sunset...

    Science.gov (United States)

    2012-10-26

    ...\\ On May 2, 2012, pursuant to 19 CFR 351.218(d)(3), The Folding Gift Boxes Fair Trade Coalition...'') Review, 77 FR 19643 (April 2, 2012). \\4\\ The Folding Gift Boxes Fair Trade Coalition is comprised of... International Trade Administration Folding Gift Boxes From the People's Republic of China: Preliminary Results...

  18. A cognitive behavioural group therapy for patients diagnosed with mild cognitive impairment and their significant others: feasibility and preliminary results

    NARCIS (Netherlands)

    Joosten-Weyn Banningh, L.W.A.; Kessels, R.P.C.; Olde Rikkert, M.G.M.; Geleijns-Lanting, C.E.

    2008-01-01

    Objective: To evaluate the feasibility and present preliminary results of a cognitive behavioural group therapy for patients with mild cognitive impairment and their significant others. Design: One group pretest-posttest design. Subjects: Twenty-two patients with mild cognitive impairment and their

  19. A cognitive behavioural group therapy for patients diagnosed with mild cognitive impairment and their significant others: feasibility and preliminary results.

    NARCIS (Netherlands)

    Joosten-Weyn Banningh, E.W.A.; Kessels, R.P.C.; Olde Rikkert, M.G.M.; Geleijns-Lanting, C.E.; Kraaimaat, F.W.

    2008-01-01

    OBJECTIVE: To evaluate the feasibility and present preliminary results of a cognitive behavioural group therapy for patients with mild cognitive impairment and their significant others. DESIGN: One group pretest-posttest design. SUBJECTS: Twenty-two patients with mild cognitive impairment and their

  20. 75 FR 13495 - Saccharin from the People's Republic of China: Preliminary Results of the 2008-2009 Antidumping...

    Science.gov (United States)

    2010-03-22

    ..., i.e., Kaifeng Xinhua Fine Chemical Factory (``Kaifeng''). We preliminarily determine that Kaifeng...., Honey from the People's Republic of China: Preliminary Results and Partial Rescission of Antidumping Duty Administrative Review, 70 FR 74764, 74765 (December 16, 2005); unchanged in Honey from the People...

  1. 75 FR 55745 - Corrosion-Resistant Carbon Steel Flat Products From the Republic of Korea: Preliminary Results...

    Science.gov (United States)

    2010-09-14

    ... International Trade Administration Corrosion-Resistant Carbon Steel Flat Products From the Republic of Korea... corrosion-resistant carbon steel flat products (CORE) from the Republic of Korea (Korea) for the period of... preliminary results of the instant administrative review. See Corrosion-Resistant Carbon Steel Flat Products...

  2. Reflectance anisotropy measurements using a pushbroom spectrometer mounted on UAV and a laboratory goniometer – preliminary results

    NARCIS (Netherlands)

    Suomalainen, J.; Roosjen, P.; Bartholomeus, H.; Clevers, J.

    2015-01-01

    During 2014–2015 we have developed a new method to measure reflectance factor anisotropy using a pushbroom spectrometer mounted on a multicopter UAV. In this paper/presentation we describe the acquisition method and show the preliminary results of the experiment. To validate the measurements the

  3. 76 FR 49437 - Certain Circular Welded Non-Alloy Steel Pipe From Mexico: Preliminary Results of Antidumping Duty...

    Science.gov (United States)

    2011-08-10

    ... International Trade Administration Certain Circular Welded Non-Alloy Steel Pipe From Mexico: Preliminary Results... circular welded non-alloy steel pipe from Mexico. This administrative review covers mandatory respondents... Circumstances Review: Certain Circular Welded Non-Alloy Steel Pipe From Mexico, 75 FR 82374 (December 30, 2010...

  4. 77 FR 66954 - Carbon and Certain Alloy Steel Wire Rod From Mexico: Preliminary Results of Antidumping Duty...

    Science.gov (United States)

    2012-11-08

    ... International Trade Administration Carbon and Certain Alloy Steel Wire Rod From Mexico: Preliminary Results of... on carbon and certain alloy steel wire rod (wire rod) from Mexico. The period of review is October 1... certain alloy steel wire rod. The product is currently classified under the Harmonized Tariff Schedule of...

  5. 78 FR 48647 - Certain Circular Welded Non-Alloy Steel Pipe from Mexico: Preliminary Results and Partial...

    Science.gov (United States)

    2013-08-09

    ... International Trade Administration Certain Circular Welded Non-Alloy Steel Pipe from Mexico: Preliminary Results... antidumping duty order on certain circular welded non-alloy steel pipe from Mexico. This administrative review... Order The products covered by the order are circular welded non-alloy steel pipes and tubes, of circular...

  6. 76 FR 55352 - Light-Walled Rectangular Pipe and Tube From Mexico: Preliminary Results and Partial Rescission of...

    Science.gov (United States)

    2011-09-07

    ... Data Submitted by Maquilacero S.A. de C.V. for the Preliminary Results of the Antidumping Duty... discounts, commissions to selling agents, and post-sale warehousing). But, as with Maquilacero, we were... Memorandum to the File for ``Analysis of Data Submitted by Regiomontana de Perfiles y Tubos S.A. de C.V. for...

  7. 76 FR 66271 - Stainless Steel Plate in Coils From Belgium: Notice of Preliminary Results of Antidumping Duty...

    Science.gov (United States)

    2011-10-26

    ... International Trade Administration Stainless Steel Plate in Coils From Belgium: Notice of Preliminary Results of... Stainless Belgium N.V. (``Aperam''), the Department of Commerce (``the Department'') initiated a changed circumstances review (``CCR'') of the antidumping duty order of stainless steel plate in coils (``SSPC'') from...

  8. 76 FR 44305 - Honey From Argentina: Extension of Time Limit for Preliminary Results of Antidumping Duty New...

    Science.gov (United States)

    2011-07-25

    ... International Trade Administration Honey From Argentina: Extension of Time Limit for Preliminary Results of... initiation a new shipper review of the antidumping duty order on honey from Argentina, covering the period of December 1, 2009, through November 30, 2010, and a single exporter of Argentine honey, Villamora S.A...

  9. 77 FR 46694 - Certain Pasta From Turkey: Notice of Preliminary Results of the 2010-2011 Antidumping Duty...

    Science.gov (United States)

    2012-08-06

    ... International Trade Administration Certain Pasta From Turkey: Notice of Preliminary Results of the 2010-2011... review of the antidumping duty order on certain pasta (pasta) from Turkey for the period of review (POR... foreign like product by Marsan were made at prices below the cost of production (COP) during the POR, in...

  10. Cross-cultural aspects of ICT use by older people: preliminary results of a four-country ethnographical study

    DEFF Research Database (Denmark)

    Blat, Josep; Sayago, Sergio; Kälviäinen, Mirja

    2011-01-01

    addresses this issue by drawing on an ethnographical study of ICT use conducted with over 120 people, aged 67-71, in four European countries: Finland, Denmark, Italy and Spain, over a 6-month period. The preliminary results show that making a social, independent and worth use of ICT are common aspects...

  11. 77 FR 17410 - Solid Urea From the Russian Federation: Extension of Time Limit for Preliminary Results of...

    Science.gov (United States)

    2012-03-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE International Trade Administration Solid Urea From the Russian Federation: Extension of Time Limit for Preliminary Results of Antidumping Duty Administrative Review AGENCY: Import Administration, International Trade Administration, Department of Commerce...

  12. 76 FR 17380 - Solid Urea From the Russian Federation: Extension of Time Limit for Preliminary Results of...

    Science.gov (United States)

    2011-03-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE International Trade Administration Solid Urea From the Russian Federation: Extension of Time Limit for Preliminary Results of Antidumping Duty Administrative Review AGENCY: Import Administration, International Trade Administration, Department of Commerce...

  13. Classroom Interaction in Effective and Ineffective Schools: Preliminary Results from Phase III of the Louisiana School Effectiveness Study

    Science.gov (United States)

    Stringfield, Samuel; Teddlie, Charles; Suarez, Sandra

    2017-01-01

    A major focus in Phase III of the Louisiana School Effectiveness Study is on the relationship between classroom interaction patterns and school effectiveness. This paper presents observations on similarities and differences between prior teacher and school effectiveness studies, the LSES-III methodology, and preliminary results from one of the…

  14. 78 FR 77653 - Fresh Garlic From the People's Republic of China: Preliminary Results and Partial Rescission of...

    Science.gov (United States)

    2013-12-24

    ... International Trade Administration Fresh Garlic From the People's Republic of China: Preliminary Results and... antidumping duty order on fresh garlic from the People's Republic of China (PRC) covering the period of review... order includes all grades of garlic, whole or separated into constituent cloves. Fresh garlic that are...

  15. 78 FR 67112 - Fresh Garlic From the People's Republic of China: Preliminary Results of New Shipper Review of...

    Science.gov (United States)

    2013-11-08

    ... International Trade Administration Fresh Garlic From the People's Republic of China: Preliminary Results of New... Co., Ltd. (Goodman) under the antidumping duty order on fresh garlic from the People's Republic of... Order The products covered by the order are all grades of garlic, whole or separated into constituent...

  16. 76 FR 2648 - Hand Trucks and Certain Parts Thereof From the People's Republic of China: Preliminary Results of...

    Science.gov (United States)

    2011-01-14

    ... Issues and Decision Memorandum at Comment 1. \\10\\ See Fresh Garlic from the People's Republic of China: Preliminary Results of New Shipper Review, 75 FR 24578 (May 5, 2010), unchanged in Fresh Garlic From the... under Sub-Classification 34 of the ISIC-Revision 3 standard by countries determined to be both...

  17. Paleomagnetism of the Todos Santos Formation in the Maya Block, Chiapas, Mexico: Preliminary Results

    Science.gov (United States)

    Godinez-Urban, A.; Molina-Garza, R. S.; Iriondo, A.; Geissman, J. W.

    2008-12-01

    Preliminary results of a paleomagnetic study on jurassic volcanic rocks (U-Pb 188.8 +/- 3.2Ma) locally interbedded with red beds assigned to the Todos Santos Formation, sampled in the Homoclinal Tectonic Province of the Neogene Fold Belt, Chiapas-Mexico, reveal multi component magnetizations acquired during pre- and post- folding of these rocks. The samples responded well to thermal demagnetization, but not so to AF demagnetization, suggesting that a high coercivity mineral phase like hematite is the main remanence carrier. The post-folding B-component direction of Dec=174.3 Inc=-30.6 (k=46; alpha95=13.6; N=4) represents a recent Tertiary? overprint; while the pre-folding C-component direction of Dec=329.9 Inc=7.8 (k=12.5; alpha95=16.3; N=8) is in agreement with a previously reported small data set for the Todos Santos Formation. When compared to the North American reference direction (Jurassic Kayenta Formation) the observed direction indicates a counterclockwise rotation of 35.9 +/- 16.6 degrees, and moderate north to south latitudinal displacement. If a reference pole from NE North America is used, the amount of counterclockwise rotation and latitudinal displacement are both slightly reduced. If the assumption that Jurassic strata in Chiapas reflect displacement of the Maya Block, then these data are consistent with reconstructions of the Maya Block in the Gulf of Mexico region. Other sites sampled in Jurassic strata suggest that in addition to the interpreted regional rotation, local (vertical-axis) rotations may have affected the region in more recent times.

  18. Scintigraphic test of gastric emptying and motility: preliminary results in patients with chronic gastritis

    Energy Technology Data Exchange (ETDEWEB)

    Hausmann, T. [Abt. Nuklearmedizin und Spezielle Biophysik, Medizinische Hochschule Hannover (Germany); Mueller-Schauenburg, W. [Abt. Nuklearmedizin, Univ. Tuebingen (Germany); Goeke, M. [Abt. Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover (Germany); Luebeck, M. [Abt. Nuklearmedizin, Univ.-Krankenhaus Eppendorf, Hamburg (Germany); Gratz, K.F. [Abt. Nuklearmedizin und Spezielle Biophysik, Medizinische Hochschule Hannover (Germany); Meier, P. [Abt. Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover (Germany); Manns, M. [Abt. Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover (Germany); Hundeshagen, H. [Abt. Nuklearmedizin und Spezielle Biophysik, Medizinische Hochschule Hannover (Germany)

    1995-11-01

    To record gastric peristalsis using a conventional scintigraphic gastric emptying test the frame rate was increased to 1 frame per 3 s at 10, 30, and 50 min postprandially. The gastric contraction frequency was obtained from the first harmonic of a Fourier transform of a gastric region of interest (ROI) curve. The propagation of gastric contractions was better revealed from computed functional images of the phase and amplitude distribution as compared with the multiple scintigraphic images. The maximal count-rate changes per pixel were calculated as an estimate of the most prominent regional contractile activity of the gastric wall. Among 12 patients with chronic gastritis the group with more severe dyspeptic complaints (n = 6) had significantly higher count-rate changes per pixel when compared with the group with minor complaints (20.0, 21.1 and 14.2 vs 12.9, 12.0, and 10.4 counts/pixel X s at 10, 30, and 50 min. respectively; p < 0.05). The mean half-times of gastric emptying (61, SD 11 vs 54, SD 13 min) and the mean gastric contraction frequencies (2.99, SD 0.19; 3.09, SD 0.33; 3.07, SD 0.10 vs 3.15, SD 0.15; 3.17, SD 0.13; 3.23, SD 0.20 cycles/min at 10, 30, and 50 min, respectively) did not show significant differences between both groups. Our preliminary results agree with the hypothesis of the occurrence of more powerful, nonexpulsive gastric-wall contractions in patients with more severe dyspeptic complaints. Hence, additional quantification of gastric motility allowed a more detailed evaluation of gastric-motor-activity disorders that were for so long not accessible to conventional gastric-emptying tests. (orig.)

  19. Preliminary Results from Electric Arc Furnace Off-Gas Enthalpy Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Nimbalkar, Sachin U [ORNL; Thekdi, Arvind [E3M Inc; Keiser, James R [ORNL; Storey, John Morse [ORNL

    2015-01-01

    This article describes electric arc furnace (EAF) off-gas enthalpy models developed at Oak Ridge National Laboratory (ORNL) to calculate overall heat availability (sensible and chemical enthalpy) and recoverable heat values (steam or power generation potential) for existing EAF operations and to test ORNL s new EAF waste heat recovery (WHR) concepts. ORNL s new EAF WHR concepts are: Regenerative Drop-out Box System and Fluidized Bed System. The two EAF off-gas enthalpy models described in this paper are: 1.Overall Waste Heat Recovery Model that calculates total heat availability in off-gases of existing EAF operations 2.Regenerative Drop-out Box System Model in which hot EAF off-gases alternately pass through one of two refractory heat sinks that store heat and then transfer it to another gaseous medium These models calculate the sensible and chemical enthalpy of EAF off-gases based on the off-gas chemical composition, temperature, and mass flow rate during tap to tap time, and variations in those parameters in terms of actual values over time. The models provide heat transfer analysis for the aforementioned concepts to confirm the overall system and major component sizing (preliminary) to assess the practicality of the systems. Real-time EAF off-gas composition (e.g., CO, CO2, H2, and H2O), volume flow, and temperature data from one EAF operation was used to test the validity and accuracy of the modeling work. The EAF off-gas data was used to calculate the sensible and chemical enthalpy of the EAF off-gases to generate steam and power. The article provides detailed results from the modeling work that are important to the success of ORNL s EAF WHR project. The EAF WHR project aims to develop and test new concepts and materials that allow cost-effective recovery of sensible and chemical heat from high-temperature gases discharged from EAFs.

  20. Work-nonwork interference: Preliminary results on the psychometric properties of a new instrument

    Directory of Open Access Journals (Sweden)

    Eileen Koekemoer

    2010-03-01

    Full Text Available Orientation: Recently, a new work-nonwork interference instrument was developed to measure the interference between work and nonwork roles in the South African context (Koekemoer, Mostert & Rothmann, 2010. However, no information is available on the psychometric properties of this instrument.Research purpose: The objectives of this study were to investigate the internal validity (construct, discriminant and convergent validity, reliability and external validity (relationship with theoretically relevant variables, including job characteristics, home characteristics, burnout, ill health and life satisfaction of the instrument.Motivation for the study: Work-family interaction is a key topic receiving significant research attention. In order to facilitate comparison across work-family studies, the use of psychometrically sound instruments is of great importance.Research design, approach and method: A cross-sectional survey design was used for the target population of married employees with children working at a tertiary institution in the North West province (n = 366. In addition to the new instrument, job characteristics, home characteristics, burnout, ill health and life satisfaction were measured.Main findings: The results provided evidence for construct, discriminant and convergent validity, reliability and significant relations with external variables.Practical/managerial implications: The new instrument can be used by researchers and managers as a test under development to investigate the interference between work and different nonwork roles (i.e. parental role, spousal role, work role, domestic role and specific relations with antecedents (e.g. job/home characteristics and well-being (e.g. burnout, ill health and life satisfaction.Contribution/value-add: This study provides preliminary information on the psychometric properties of a new instrument that measures the interference between work and nonwork.

  1. Large-scale dynamic compaction demonstration using WIPP salt: Fielding and preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Ahrens, E.H.; Hansen, F.D. [Sandia National Labs., Albuquerque, NM (United States). Nuclear Waste Technology Repository Isolation Systems

    1995-10-01

    Reconsolidation of crushed rock salt is a phenomenon of great interest to programs studying isolation of hazardous materials in natural salt geologic settings. Of particular interest is the potential for disaggregated salt to be restored to nearly an impermeable state. For example, reconsolidated crushed salt is proposed as a major shaft seal component for the Waste Isolation Pilot Plant (WIPP) Project. The concept for a permanent shaft seal component of the WIPP repository is to densely compact crushed salt in the four shafts; an effective seal will then be developed as the surrounding salt creeps into the shafts, further consolidating the crushed salt. Fundamental information on placement density and permeability is required to ensure attainment of the design function. The work reported here is the first large-scale compaction demonstration to provide information on initial salt properties applicable to design, construction, and performance expectations. The shaft seals must function for 10,000 years. Over this period a crushed salt mass will become less permeable as it is compressed by creep closure of salt surrounding the shaft. These facts preclude the possibility of conducting a full-scale, real-time field test. Because permanent seals taking advantage of salt reconsolidation have never been constructed, performance measurements have not been made on an appropriately large scale. An understanding of potential construction methods, achievable initial density and permeability, and performance of reconsolidated salt over time is required for seal design and performance assessment. This report discusses fielding and operations of a nearly full-scale dynamic compaction of mine-run WIPP salt, and presents preliminary density and in situ (in place) gas permeability results.

  2. Repetitive transcranial magnetic stimulation as an adjuvant method in the treatment of depression: Preliminary results

    Directory of Open Access Journals (Sweden)

    Jovičić Milica

    2014-01-01

    Full Text Available Introduction. Repetitive transcranial magnetic stimulation (rTMS is a method of brain stimulation which is increasingly used in both clinical practice and research. Up-to-date studies have pointed out a potential antidepressive effect of rTMS, but definitive superiority over placebo has not yet been confirmed. Objective. The aim of the study was to examine the effect of rTMS as an adjuvant treatment with antidepressants during 18 weeks of evaluation starting from the initial application of the protocol. Methods. Four patients with the diagnosis of moderate/severe major depression were included in the study. The protocol involved 2000 stimuli per day (rTMS frequency of 10 Hz, intensity of 120% motor threshold administered over the left dorsolateral prefrontal cortex (DLPFC for 15 days. Subjective and objective depressive symptoms were measured before the initiation of rTMS and repeatedly evaluated at week 3, 6, 12 and 18 from the beginning of the stimulation. Results. After completion of rTMS protocol two patients demonstrated a reduction of depressive symptoms that was sustained throughout the 15-week follow-up period. One patient showed a tendency of remission during the first 12 weeks of the study, but relapsed in week 18. One patient showed no significant symptom reduction at any point of follow-up. Conclusion. Preliminary findings suggest that rTMS has a good tolerability and can be efficient in accelerating the effect of antidepressants, particularly in individuals with shorter duration of depressive episodes and moderate symptom severity. [Projekat Ministarstva nauke Republike Srbije, br. III41029 i br. ON175090

  3. {sup 18}F-FDG positron emission tomography in the early diagnosis of enterocolitis: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Kresnik, E.; Gallowitsch, H.J.; Igerc, I.; Kumnig, G.; Gomez, I.; Lind, P. [Nuclear Medicine and Special Endocrinology, PET Centre, General Hospital, St. Veiterstrasse 47, 9020 Klagenfurt (Austria); Mikosch, P.; Alberer, D.; Hebenstreit, A. [Department of Internal Medicine and Gastroenterology, General Hospital, Klagenfurt (Austria); Wuertz, F. [Department of Pathology, General Hospital, Klagenfurt (Austria); Kogler, D.; Gasser, J. [Department of Radiology, General Hospital, Klagenfurt (Austria)

    2002-10-01

    Collagenous and eosinophilic colitis are rare diseases characterised by chronic watery diarrhoea. Radiographic evaluation of the gastrointestinal tract and colonoscopy are usually non-diagnostic since as many as one-third of patients will have minor abnormalities. To date a few investigators have reported increased fluorine-18 fluorodeoxyglucose ({sup 18}F-FDG) uptake on positron emission tomography (PET) in patients with acute enterocolitis, but there have been no reports on the use of {sup 18}F-FDG PET for the diagnosis of collagenous or eosinophilic colitis in an early clinical stage. The aim of this preliminary study was to evaluate the usefulness of {sup 18}F-FDG PET in the early diagnosis of patients with colitis. We investigated five women (mean age 61.2{+-}12.1 years) who had been diagnosed as having colitis in an early clinical stage. In all but one of the patients, the diagnosis of colitis was based on biopsy. Magnetic resonance colonography, ultrasonography and colonoscopy were performed in all but one of the patients. Two women were identified as having collagenous colitis in an early clinical stage. Another two patients had eosinophilic colitis. The morphological imaging methods, magnetic resonance colonography and ultrasonography, yielded no suspicious findings, and the results of colonoscopy similarly showed no abnormalities. One patient had colitis due to bacterial infection. In all patients {sup 18}F-FDG PET showed a pathological increase in tracer uptake in the large bowel, suggestive of colitis. In four of the five patients, colitis was confirmed by histology, and in one, by bacterial analysis. {sup 18}F-FDG PET was able to detect colitis in an early clinical stage, when morphological imaging methods and colonoscopy were non-diagnostic. The early performance of {sup 18}F-FDG PET imaging in patients with possible colitis is encouraging. (orig.)

  4. Preliminary results of geologic and remote sensing studies of Rima Mozart

    Science.gov (United States)

    Coombs, C. R.; Hawke, B. R.

    1987-01-01

    In order to better understand the processes responsible for the formation of lunar sinuous rilles, a study of Rima Mozart was conducted using a variety of geologic, photographic, and remote sensing data. The apparent source of this rille is located in a highlands unit of known composition and it is hypothesized that thermal and mechanical erosion played an important role in the formation of Rima Mozart. Excellent photographic, topographic, multispectral, and radar data exist for this rille. The preliminary results of an analysis of this data are presented. Photographic data indicates the presence of two volcanic source vents for Rima Mozart: Kathleen and Ann. It is suggested that Rima Mozart, like many other lunar sinuous rilles, was most likely formed by a combination of events. Rima Mozart does follow a pre-existing, dominant NW/SE structural trend suggesting the influence of structural features on the rille, however, the tectonic influence is not the sole source for the formation of the rille, as suggested by the presence of the two source vents and the spatter around Ann. It is suggested that the rille formation began with an explosive eruption at Kathleen which later calmed down to a pulsating, high volume, low-viscosity lava flow. The rapid effusion rate of the magma as well as its high temperature and turbid nature helped carve the sinuous rille into the fractured and structurally weak Apennine Bench Formation underneath. Similar eruptions and subsequent flows were also created at Ann and joined to the main channel by a NE-trending secondary rille.

  5. The preliminary results: Internal seismic velocity structure imaging beneath Mount Lokon

    Energy Technology Data Exchange (ETDEWEB)

    Firmansyah, Rizky, E-mail: rizkyfirmansyah@hotmail.com [Geophysical Engineering, Faculty of Mining and Petroleum Engineering, Institut Teknologi Bandung, Bandung, 40132 (Indonesia); Nugraha, Andri Dian, E-mail: nugraha@gf.itb.ac.id [Global Geophysical Group, Faculty of Mining and Petroleum Engineering, Institut Teknologi Bandung, Bandung, 40132 (Indonesia); Kristianto, E-mail: kris@vsi.esdm.go.id [Center for Volcanology and Geological Hazard Mitigation (CVGHM), Geological Agency, Bandung, 40122 (Indonesia)

    2015-04-24

    Historical records that before the 17{sup th} century, Mount Lokon had been dormant for approximately 400 years. In the years between 1350 and 1400, eruption ever recorded in Empung, came from Mount Lokon’s central crater. Subsequently, in 1750 to 1800, Mount Lokon continued to erupt again and caused soil damage and fall victim. After 1949, Mount Lokon dramatically increased in its frequency: the eruption interval varies between 1 – 5 years, with an average interval of 3 years and a rest interval ranged from 8 – 64 years. Then, on June 26{sup th}, 2011, standby alert set by the Center for Volcanology and Geological Hazard Mitigation. Peak activity happened on July 4{sup th}, 2011 that Mount Lokon erupted continuously until August 28{sup th}, 2011. In this study, we carefully analyzed micro-earthquakes waveform and determined hypocenter location of those events. We then conducted travel time seismic tomographic inversion using SIMULPS12 method to detemine Vp, Vs and Vp/Vs ratio structures beneath Lokon volcano in order to enhance our subsurface geological structure. During the tomographic inversion, we started from 1-D seismic velocities model obtained from VELEST33 method. Our preliminary results show low Vp, low Vs, and high Vp/Vs are observed beneath Mount Lokon-Empung which are may be associated with weak zone or hot material zones. However, in this study we used few station for recording of micro-earthquake events. So, we suggest in the future tomography study, the adding of some seismometers in order to improve ray coverage in the region is profoundly justified.

  6. Effect of observation on lower limb prosthesis gait biomechanics: Preliminary results.

    Science.gov (United States)

    Malchow, Connor; Fiedler, Goeran

    2016-12-01

    The Hawthorne effect, a subcategory of reactivity, causes human behavior to change when under observation. Such an effect may apply to gait variation of persons with prosthetics or orthotics devices. This study investigated whether the presence of observers directly affects the gait pattern of users of lower limb prostheses. Within-subject intervention study. Primary outcome measures were gait parameters of initial double support time and upper body lateral tilt angle, which were collected with a mobile sensor attached to the subjects' back. To make subjects feel unwatched, a certain amount of deception was necessary, and two different conditions were created and statistically compared against each other: one in which the subjects were initially unaware of the attention of observers and another one in which the same subjects were aware of a group of observers. Data from two subjects using trans-femoral prosthesis are reported. Findings included a change in step initial double support percentage by up to 14.2% (p = 0.019). Considerable changes were also noted in secondary outcome measures including speed, stride length, and stride symmetry. A reactivity effect of observation exists in prosthetics gait analysis. More comprehensive studies may be motivated by these preliminary findings. Results of this study suggest that users of lower limb prostheses walk differently when their gait is being assessed (e.g. in the prosthetist's office) than in situations without observers. This may in part explain the clinical experience that modifications of prosthetic fit or alignment provide only short-term betterment. © The International Society for Prosthetics and Orthotics 2015.

  7. Microendoscopic anterior approach for irreducible atlantoaxial dislocation: surgical techniques and preliminary results.

    Science.gov (United States)

    Wu, Yao-Sen; Chi, Yong-Long; Wang, Xiang-Yang; Xu, Hua-Zi; Lin, Yan; Mao, Fang-Min; Huang, Qi-Shan; Ni, Wen-Fei

    2010-04-01

    Surgical techniques and preliminary results. To describe and evaluate the safety and efficacy of a new minimal invasive technique for the irreducible atlantoaxial dislocation (IADD). Endoscope has been widely used in minimal invasive spinal surgery. However, there are no clinical reports regarding anterior approach for IADD in the literature. Ten consecutive patients with IADD were treated by anterior release with microendoscopic aide and subsequently reduction, anterior transarticular screw fixation and morselized autologous bone grafts. There were 3 cases of odontoid dysplasia, 4, chronic odontoid fracture, 1, odontoid absence, 1 fasilar impression, and 1 malunion of odontoid fracture. According to Symon and Lavender's classification of disability, 6 cases were moderate disability, 3 severe nonbedbound, and 1 severe bedridden. The procedure was performed by the same surgeon (Yong-Long Chi). The new technique was performed successfully in all cases. All the patients underwent transarticular screw fixation and anterior morselized autograft fusion. The average operation time was 120 min (range, 90 to 150 min) and the mean estimated blood loss was 150 mL (range, 100 to 250 mL). Postoperative radiographs demonstrated that 9 cases restored anatomic position and 1 had partial reduction. According to the postoperative computed tomography all the screws were appropriately placed. Follow-up after surgery, longest is 16 months and minimal 8 months with a mean of 12 months, neurologic status was improved in all patients. There was no loss of fixation and solid fusion was achieved in all cases. Surgical technique of microendoscopic anterior release, reduction, fixation, and fusion is safe and reliable minimally invasive for treating IADD.

  8. Factors associated with idiopathic adolescent scoliosis in female population - preliminary results

    Directory of Open Access Journals (Sweden)

    Talić Goran

    2017-01-01

    Full Text Available Introduction/Objective. Idiopathic scoliosis (IS is an orthopedic condition of multifactorial origin. The aim of our study was to evaluate the factors that are associated with IS in female population and factors associated with varicose veins in females with IS. Methods. This retrospective-prospective cross-section study included 89 patients (the study group and 87 controls. The following parameters were analyzed: body weight, body height, presence and the degree of varicose veins (the first, second, and third degree, and age (group in the range of 17–26 years, in the range of 27–36 years, and in the range of 37–46 years. Results. The study group has significantly lower body weight (p = 0.046, significantly higher proportion of varicose veins (p < 0.001 compared to controls, significantly lower proportion of patients aged 27–36 years (p = 0.014, and significantly higher proportion of patients aged 37–46 years (p = 0.025 compared to controls. There is significantly higher proportion of patients in the study group with the first degree of varicose veins (p = 0.007. There is weak positive correlation between body weight and body height in the group of patients without varicose veins (R = 0.456 and in the group with the second degree of varicose veins (R = 0.291, while for the group with the first degree of varicose veins there is moderate positive correlation (R = 0.543. Conclusion. Our preliminary findings point out that lower body weight and presence of varicose veins are significantly associated with IS. The group of patients with IS above 37 years of age tends to have significantly higher proportion of varicose veins.

  9. The Electrically Evoked Auditory Change Complex: Preliminary Results from Nucleus Cochlear Implant Users

    Science.gov (United States)

    Brown, Carolyn J.; Etler, Christine; He, Shuman; O’Brien, Sara; Erenberg, Sheryl; Kim, Jae-Ryong; Dhuldhoya, Aayesha N.; Abbas, Paul J.

    2009-01-01

    amplitude was shown to increase as the separation between the two stimulating electrodes increased. While preliminary in nature, these results demonstrate the feasibility of recording the EACC in response to changes in stimulating electrode position from individual cochlear implant users. PMID:18596644

  10. 78 FR 41364 - Chlorinated Isocyanurates From the People's Republic of China: Preliminary Results of Antidumping...

    Science.gov (United States)

    2013-07-10

    ... China: No Sales Certification,'' September 18, 2012. \\3\\ See Non-Market Economy Antidumping Proceedings... International Trade Administration Chlorinated Isocyanurates From the People's Republic of China: Preliminary... isos) from the People's Republic of China (PRC). The period of review (POR) is June 1, 2011, through...

  11. 78 FR 26748 - Certain Activated Carbon From the People's Republic of China: Preliminary Results of Antidumping...

    Science.gov (United States)

    2013-05-08

    ... International Trade Administration Certain Activated Carbon From the People's Republic of China: Preliminary... duty order on certain activated carbon from the People's Republic of China (``PRC'') for the period of... The merchandise subject to the order is certain activated carbon.\\1\\ The products are currently...

  12. 78 FR 34640 - Certain Lined Paper Products From the People's Republic of China: Preliminary Results and...

    Science.gov (United States)

    2013-06-10

    ... International Trade Administration Certain Lined Paper Products From the People's Republic of China: Preliminary... certain lined paper products (``CLPP'') from the People's Republic of China (``PRC''). The period of... the People's Republic of China; Notice of Antidumping Duty Orders: Certain Lined Paper Products from...

  13. 75 FR 16439 - Certain Welded Carbon Steel Standard Pipe From Turkey: Preliminary Results of Countervailing Duty...

    Science.gov (United States)

    2010-04-01

    ... military pension fund. On November 20, 2009, the Department postponed the deadline for the preliminary... of a direct transfer of funds from the GOT, under section 771(5)(D)(i) of the Act. A benefit exists... loans constitute a financial contribution in the form of a direct transfer of funds from the GOT, under...

  14. 78 FR 15683 - Certain Preserved Mushrooms From the People's Republic of China: Preliminary Results of...

    Science.gov (United States)

    2013-03-12

    ... International Trade Administration Certain Preserved Mushrooms From the People's Republic of China: Preliminary... order on certain preserved mushrooms (mushrooms) from the People's Republic of China (PRC) covering the... Co., Ltd. should be equated with Zhejiang Iceman Group Co., Ltd. See Certain Preserved Mushrooms From...

  15. 76 FR 12704 - Certain Preserved Mushrooms From the People's Republic of China: Preliminary Results of...

    Science.gov (United States)

    2011-03-08

    ... International Trade Administration Certain Preserved Mushrooms From the