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Sample records for born subventricular zone

  1. Glioblastoma Multiforme: Relationship to Subventricular Zone and Recurrence

    OpenAIRE

    Kimura, Margareth; Lee, Yeuh; Miller, Ryan; Castillo, Mauricio

    2013-01-01

    Neurogenesis in the adult mammalian brain is active in two areas: the subgranular zone in the dentate gyrus of the hippocampus and the subventricular zone. Cancer stem cells have been isolated from malignant brain tumors and it is widely believed they arise from transformed endogenous stem cells. We sought to determine if the initial location of glioblastoma (GB) as seen on conventional MRI and its relationship to the subventricular zone (SVZ) predicts the pattern of recurrence. We analyzed t...

  2. Subventricular zone cytoarchitecture changes in autism.

    Science.gov (United States)

    Kotagiri, Prasanti; Chance, Steven A; Szele, Francis G; Esiri, Margaret M

    2014-01-01

    Autism is thought to be a neurodevelopmental disorder with symptoms developing during neonatal neurogenesis in the subventricular zone (SVZ). Autism associated genes alter SVZ proliferation and cytoarchitecture, yet the response of the human SVZ in autism is unknown. Epilepsy drives neurogenesis in rodents, but it is unclear how epilepsy interacts with autism in SVZ responses. The striatal and septal SVZ derive from separate lineages in rodents and generate different interneuron types. Yet it is unclear if autism unevenly regulates the striatal and septal SVZ. The human SVZ was immunohistochemically examined post-mortem from individuals with autism (n = 11) and controls (n = 11). Autism showed a lower cell density in the septal, but not striatal, SVZ hypocellular gap only in the absence of epilepsy. There was a decline in septal hypocellular gap cells with age in autism, but no correlation with age in controls. In contrast, PCNA+ cell numbers increased only in autism with epilepsy both in the hypocellular gap and in the ependymal layer on the septal but not striatal side. Ependymal cells also became GFAP immunoreactive in autism irrespective of epilepsy co-morbidity; however, this only occurred on the striatal side. In examining these questions we also discovered a subset of ependymal, astrocyte ribbon and RMS cells which express PCNA and Ki67, PLP, and α-tubulin. These results are the first example of a neuropsychiatric disease differentially affecting the septal and striatal SVZ. Altered cell density in the hypocellular gap and proliferation marker expression suggest individuals with autism may follow a different growth-trajectory. PMID:24002902

  3. Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity.

    Science.gov (United States)

    Butti, Erica; Bacigaluppi, Marco; Rossi, Silvia; Cambiaghi, Marco; Bari, Monica; Cebrian Silla, Arantxa; Brambilla, Elena; Musella, Alessandra; De Ceglia, Roberta; Teneud, Luis; De Chiara, Valentina; D'Adamo, Patrizia; Garcia-Verdugo, Jose Manuel; Comi, Giancarlo; Muzio, Luca; Quattrini, Angelo; Leocani, Letizia; Maccarrone, Mauro; Centonze, Diego; Martino, Gianvito

    2012-11-01

    The functional significance of adult neural stem and progenitor cells in hippocampal-dependent learning and memory has been well documented. Although adult neural stem and progenitor cells in the subventricular zone are known to migrate to, maintain and reorganize the olfactory bulb, it is less clear whether they are functionally required for other processes. Using a conditional transgenic mouse model, selective ablation of adult neural stem and progenitor cells in the subventricular zone induced a dramatic increase in morbidity and mortality of central nervous system disorders characterized by excitotoxicity-induced cell death accompanied by reactive inflammation, such as 4-aminopyridine-induced epilepsy and ischaemic stroke. To test the role of subventricular zone adult neural stem and progenitor cells in protecting central nervous system tissue from glutamatergic excitotoxicity, neurophysiological recordings of spontaneous excitatory postsynaptic currents from single medium spiny striatal neurons were measured on acute brain slices. Indeed, lipopolysaccharide-stimulated, but not unstimulated, subventricular zone adult neural stem and progenitor cells reverted the increased frequency and duration of spontaneous excitatory postsynaptic currents by secreting the endocannabinod arachidonoyl ethanolamide, a molecule that regulates glutamatergic tone through type 1 cannabinoid receptor (CB(1)) binding. In vivo restoration of cannabinoid levels, either by administration of the type 1 cannabinoid receptor agonist HU210 or the inhibitor of the principal catabolic enzyme fatty acid amide hydrolase, URB597, completely reverted the increased morbidity and mortality of adult neural stem and progenitor cell-ablated mice suffering from epilepsy and ischaemic stroke. Our results provide the first evidence that adult neural stem and progenitor cells located within the subventricular zone exert an 'innate' homeostatic regulatory role by protecting striatal neurons from glutamate

  4. Subventricular zone cell migration: lessons from quantitative 2-photon microscopy

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    Rachel eJames

    2011-03-01

    Full Text Available Neuroblasts born in the adult subventricular zone (SVZ migrate long distances in the rostral migratory stream (RMS to the olfactory bulbs where they integrate into circuitry as functional interneurons. As very little was known about the dynamic parameters of SVZ neuroblast migration, we used two-photon time-lapse microscopy to analyze migration in acute slices. This involved analyzing 3-dimensional stacks of images over time and uncovered several novel aspects of SVZ migration: chains remain stable, cells can be immotile for extensive periods, morphology does not necessarily correlate with motility, neuroblasts exhibit local exploratory motility, dorsoventral migration occurs throughout the striatal SVZ and neuroblasts turn at distinctive angles. We investigated these novel findings in the SVZ and RMS from the population to the single cell level. In this review we also discuss some technical considerations when setting up a two-photon microscopic imaging system. Throughout the review we identify several unsolved questions about SVZ neuroblast migration that might be addressed with current or emerging techniques.

  5. Neuropeptide y promotes neurogenesis in murine subventricular zone

    DEFF Research Database (Denmark)

    Agasse, Fabienne; Bernardino, Liliana; Christiansen, Søren H; Ferreira, Raquel; Silva, Bruno; Grade, Sofia; Woldbye, David P D; Malva, João O; Kristiansen, Heidi

    2008-01-01

    Stem cells of the subventricular zone (SVZ) represent a reliable source of neurons for cell replacement. Neuropeptide Y (NPY) promotes neurogenesis in the hippocampal subgranular layer and the olfactory epithelium and may be useful for the stimulation of SVZ dynamic in brain repair purposes. We...... describe that NPY promotes SVZ neurogenesis. NPY (1 microM) treatments increased proliferation at 48 hours and neuronal differentiation at 7 days in SVZ cell cultures. NPY proneurogenic properties are mediated via the Y1 receptor. Accordingly, Y1 receptor is a major active NPY receptor in the mouse SVZ, as......-Jun-NH(2)-terminal kinase signal in growing axons, consistent with axonogenesis. NPY, as a promoter of SVZ neurogenesis, is a crucial factor for future development of cell-based brain therapy. Disclosure of potential conflicts of interest is found at the end of this article....

  6. Implications of irradiating the subventricular zone stem cell niche

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    Vivian Capilla-Gonzalez

    2016-03-01

    Full Text Available Radiation therapy is a standard treatment for brain tumor patients. However, it comes with side effects, such as neurological deficits. While likely multi-factorial, the effect may in part be associated with the impact of radiation on the neurogenic niches. In the adult mammalian brain, the neurogenic niches are localized in the subventricular zone (SVZ of the lateral ventricles and the dentate gyrus of the hippocampus, where the neural stem cells (NSCs reside. Several reports showed that radiation produces a drastic decrease in the proliferative capacity of these regions, which is related to functional decline. In particular, radiation to the SVZ led to a reduced long-term olfactory memory and a reduced capacity to respond to brain damage in animal models, as well as compromised tumor outcomes in patients. By contrast, other studies in humans suggested that increased radiation dose to the SVZ may be associated with longer progression-free survival in patients with high-grade glioma. In this review, we summarize the cellular and functional effects of irradiating the SVZ niche. In particular, we review the pros and cons of using radiation during brain tumor treatment, discussing the complex relationship between radiation dose to the SVZ and both tumor control and toxicity.

  7. Pbx1 is required for adult subventricular zone neurogenesis.

    Science.gov (United States)

    Grebbin, Britta Moyo; Hau, Ann-Christin; Groß, Anja; Anders-Maurer, Marie; Schramm, Jasmine; Koss, Matthew; Wille, Christoph; Mittelbronn, Michel; Selleri, Licia; Schulte, Dorothea

    2016-07-01

    TALE-homeodomain proteins function as components of heteromeric complexes that contain one member each of the PBC and MEIS/PREP subclasses. We recently showed that MEIS2 cooperates with the neurogenic transcription factor PAX6 in the control of adult subventricular zone (SVZ) neurogenesis in rodents. Expression of the PBC protein PBX1 in the SVZ has been reported, but its functional role(s) has not been investigated. Using a genetic loss-of-function mouse model, we now show that Pbx1 is an early regulator of SVZ neurogenesis. Targeted deletion of Pbx1 by retroviral transduction of Cre recombinase into Pbx2-deficient SVZ stem and progenitor cells carrying floxed alleles of Pbx1 significantly reduced the production of neurons and increased the generation of oligodendrocytes. Loss of Pbx1 expression in neuronally committed neuroblasts in the rostral migratory stream in a Pbx2 null background, by contrast, severely compromised cell survival. By chromatin immunoprecipitation from endogenous tissues or isolated cells, we further detected PBX1 binding to known regulatory regions of the neuron-specific genes Dcx and Th days or even weeks before the respective genes are expressed during the normal program of SVZ neurogenesis, suggesting that PBX1 might act as a priming factor to mark these genes for subsequent activation. Collectively, our results establish that PBX1 regulates adult neural cell fate determination in a manner beyond that of its heterodimerization partner MEIS2. PMID:27226325

  8. Modulation of subventricular zone oligodendrogenesis: a role for hemopressin?

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    Sara eXapelli

    2014-02-01

    Full Text Available Neural stem cells (NSCs from the subventricular zone (SVZ have been indicated as a source of new oligodendrocytes to use in regenerative medicine for myelin pathologies. Indeed, NSCs are multipotent cells that can self-renew and differentiate into all neural cell types of the central nervous system (CNS. In normal conditions, SVZ cells are poorly oligodendrogenic, nevertheless their oligodendrogenic potential is boosted following demyelination. Importantly, progressive restriction into the oligodendrocyte fate is specified by extrinsic and intrinsic factors, endocannabinoids being one of these factors. Although a role for endocannabinoids in oligodendrogenesis has already been foreseen, selective agonists and antagonists of cannabinoids receptors produce severe adverse side effects. Herein, we show that hemopressin, a modulator of CB1 receptors, increased oligodendroglial differentiation in SVZ neural stem/progenitor cell cultures derived from neonatal mice. The original results presented in this work suggest that hemopressin and derivatives may be of potential interest for the development of future strategies to treat demyelinating diseases.

  9. Neural stem cells, the subventricular zone and radiotherapy: implications for treating glioblastoma.

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    Smith, Andrew W; Mehta, Minesh P; Wernicke, A Gabriella

    2016-06-01

    Over the past decade, advances in neuroscience have suggested that neural stem cells resident in specific regions of the adult brain may be involved in development of both primary and recurrent glioblastoma. Neurogenesis and malignant transformation occurs in the subventricular zone adjacent to the lateral ventricles. This region holds promise as a potential target for therapeutic intervention with radiotherapy. However, irradiation of a larger brain volume is not without risk, and significant side effects have been observed. The current literature remains contradictory regarding the efficacy of deliberate intervention with radiation to the subventricular zone. This critical review discusses the connection between neural stem cells and development of glioblastoma, explores the behavior of tumors associated with the subventricular zone, summarizes the discordant literature with respect to the effects of irradiation, and reviews other targeted therapies to this intriguing region. PMID:27108274

  10. The path from the choroid plexus to the subventricular zone: go with the flow!

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    Ana Mendanha Falcao

    2012-08-01

    Full Text Available In adult mammals, under physiological conditions, neurogenesis, the process of generating new functional neurons from precursor cells, occurs mainly in two brain areas: the subgranular zone in the dentate gyrus of the hippocampus, and the subventricular zone (SVZ lining the walls of the brain lateral ventricles. Taking into account the location of the SVZ and the cytoarchitecture of this periventricular neural progenitor cell niche, namely the fact that the slow dividing primary progenitor cells (type B cells of the SVZ extend an apical primary cilium towards the brain ventricular space which is filled with cerebrospinal fluid (CSF, it becomes likely that the composition of the CSF can modulate both self-renewal, proliferation and differentiation of SVZ neural stem cells. The major site of CSF synthesis is the choroid plexus (CP; quite surprisingly, however, it is still largely unknown the contribution of molecules specifically secreted by the adult CP as modulators of the SVZ adult neurogenesis. This is even more relevant in light of recent evidence showing the ability of the CP to adapt its transcriptome and secretome to various physiologic and pathologic stimuli. By giving particular emphasizes to growth factors and axonal guidance molecules we will illustrate how CP-born molecules might play an important role in the SVZ niche cell population dynamics.

  11. Dopaminergic innervation of the human subventricular zone: a comparison between Huntington’s chorea and Parkinson’s disease

    OpenAIRE

    Parent, Martin; Bédard, C; Pourcher, E

    2013-01-01

    The subventricular zone retains its neurogenic capacity throughout life and, as such, is often considered a potential source for endogenous repair in neurodegenerative disorders. Because dopamine is believed to stimulate adult neurogenesis, we looked for possible variations in the dopaminergic innervation of the subventricular zone between cases of Huntington’s chorea and Parkinson’s diseases. Antibodies against tyrosine hydroxylase (TH) and proliferating cell nuclear antigen (PCNA) were used...

  12. Stem cell associated gene expression in glioblastoma multiforme: relationship to survival and the subventricular zone

    OpenAIRE

    Kappadakunnel, Melanie; Eskin, Ascia; DONG, JUN; Nelson, Stanley F.; Mischel, Paul S.; Liau, Linda M.; Ngheimphu, Phioanh; Lai, Albert; Cloughesy, Timothy F.; Goldin, Jonathan; Pope, Whitney B.

    2009-01-01

    Current therapies for glioblastoma (GBM) target bulk tumor through measures such as resection and radiotherapy. However, recent evidence suggests that targeting a subset of tumor cells, so-called cancer stem cells, may be critical for inhibiting tumor growth and relapse. The subventricular zone (SVZ), which lines the ventricles of the brain, is thought to be the origin for the majority of neural stem cells and potentially cancer stem cells. Therefore, we assessed the relationship between tumo...

  13. Rat Dlx5 is expressed in the subventricular zone and promotes neuronal differentiation

    OpenAIRE

    H.F. Shu; Gao, F. Y; Zhang, C. Q.; Liu, S.Y.; Z. Y. Zhang; Y.C. Song; Qiu, K. J.; Yang, H.(Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China; Department of Modern Physics, University of Science and Technology of China, Anhui, China; Department of Physics, Nanjing University, Jiangsu, China; School of Physics, Shandong University, Shandong, China; Department of Physics and Astronomy, Shanghai Key Laboratory for Particle Physics and Cosmology, Shanghai Jiao Tong University, Shanghai, China; Physics Department, Tsinghua University, 100084, Beijing, China)

    2010-01-01

    The molecular mechanisms and potential clinical applications of neural precursor cells have recently been the subject of intensive study. Dlx5, a homeobox transcription factor related to the distal-less gene in Drosophila, was shown to play an important role during forebrain development. The subventricular zone (SVZ) in the adult brain harbors the largest abundance of neural precursors. The anterior SVZ (SVZa) contains the most representative neural precursors in the SVZ. Further research is ...

  14. New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesis

    OpenAIRE

    Eiriz, Maria F.; Valero, Jorge; João O. Malva; Bernardino, Liliana

    2014-01-01

    The subventricular zone (SVZ) contains neural stem cells (NSCs) that generate new neurons throughout life. Many brain diseases stimulate NSCs proliferation, neuronal differentiation and homing of these newborns cells into damaged regions. However, complete cell replacement has never been fully achieved. Hence, the identification of proneurogenic factors crucial for stem cell-based therapies will have an impact in brain repair. Histamine, a neurotransmitter and immune mediator, has been recent...

  15. A model of ischemia-induced neuroblast activation in the adult subventricular zone.

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    Davide Vergni

    Full Text Available We have developed a rat brain organotypic culture model, in which tissue slices contain cortex-subventricular zone-striatum regions, to model neuroblast activity in response to in vitro ischemia. Neuroblast activation has been described in terms of two main parameters, proliferation and migration from the subventricular zone into the injured cortex. We observed distinct phases of neuroblast activation as is known to occur after in vivo ischemia. Thus, immediately after oxygen/glucose deprivation (6-24 hours, neuroblasts reduce their proliferative and migratory activity, whereas, at longer time points after the insult (2 to 5 days, they start to proliferate and migrate into the damaged cortex. Antagonism of ionotropic receptors for extracellular ATP during and after the insult unmasks an early activation of neuroblasts in the subventricular zone, which responded with a rapid and intense migration of neuroblasts into the damaged cortex (within 24 hours. The process is further enhanced by elevating the production of the chemoattractant SDf-1alpha and may also be boosted by blocking the activation of microglia. This organotypic model which we have developed is an excellent in vitro system to study neurogenesis after ischemia and other neurodegenerative diseases. Its application has revealed a SOS response to oxygen/glucose deprivation, which is inhibited by unfavorable conditions due to the ischemic environment. Finally, experimental quantifications have allowed us to elaborate a mathematical model to describe neuroblast activation and to develop a computer simulation which should have promising applications for the screening of drug candidates for novel therapies of ischemia-related pathologies.

  16. Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Niche

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    Chang, Eun Hyuk; Adorjan, Istvan; Mundim, Mayara V.; Sun, Bin; Dizon, Maria L. V.; Szele, Francis G.

    2016-01-01

    Traumatic brain injury (TBI) is common in both civilian and military life, placing a large burden on survivors and society. However, with the recognition of neural stem cells in adult mammals, including humans, came the possibility to harness these cells for repair of damaged brain, whereas previously this was thought to be impossible. In this review, we focus on the rodent adult subventricular zone (SVZ), an important neurogenic niche within the mature brain in which neural stem cells continue to reside. We review how the SVZ is perturbed following various animal TBI models with regards to cell proliferation, emigration, survival, and differentiation, and we review specific molecules involved in these processes. Together, this information suggests next steps in attempting to translate knowledge from TBI animal models into human therapies for TBI. PMID:27531972

  17. Roles of Wnt Signaling in the Neurogenic Niche of the Adult Mouse Ventricular-Subventricular Zone.

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    Hirota, Yuki; Sawada, Masato; Huang, Shih-Hui; Ogino, Takashi; Ohata, Shinya; Kubo, Akiharu; Sawamoto, Kazunobu

    2016-02-01

    In many animal species, the production of new neurons (neurogenesis) occurs throughout life, in a specialized germinal region called the ventricular-subventricular zone (V-SVZ). In this region, neural stem cells undergo self-renewal and generate neural progenitor cells and new neurons. In the olfactory system, the new neurons migrate rostrally toward the olfactory bulb, where they differentiate into mature interneurons. V-SVZ-derived new neurons can also migrate toward sites of brain injury, where they contribute to neural regeneration. Recent studies indicate that two major branches of the Wnt signaling pathway, the Wnt/β-catenin and Wnt/planar cell polarity pathways, play essential roles in various facets of adult neurogenesis. Here, we review the Wnt signaling-mediated regulation of adult neurogenesis in the V-SVZ under physiological and pathological conditions. PMID:26572545

  18. A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone

    DEFF Research Database (Denmark)

    Ribeiro Xavier, Anna L.; Kress, Benjamin T.; Goldman, Steven A.;

    2015-01-01

    Microglia are involved in synaptic pruning both in development and in the mature CNS. In this study, we investigated whether microglia might further contribute to circuit plasticity by modulating neuronal recruitment from the neurogenic subventricular zone (SVZ) of the adult mouse striatum. We...... expression of purinoceptors and lack of ATP-elicitable chemotaxis. Furthermore, the in vivo depletion of these microglia hampered the survival and migration of newly generated neuroblasts through the RMS to the olfactory bulb. SVZ and RMS microglia thus appear to comprise a functionally distinct class that...... is selectively adapted to the support and direction of neuronal integration into the olfactory circuitry. Therefore, this unique microglial subpopulation may serve as a novel target with which to modulate cellular addition from endogenous neural stem and progenitor cells of the adult brain...

  19. Aberrant Adult Neurogenesis in the Subventricular Zone-Rostral Migratory Stream-Olfactory Bulb System Following Subchronic Manganese Exposure.

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    Fu, Sherleen; Jiang, Wendy; Gao, Xiang; Zeng, Andrew; Cholger, Daniel; Cannon, Jason; Chen, Jinhui; Zheng, Wei

    2016-04-01

    Adult neurogenesis occurs in brain subventricular zone (SVZ). Our recent data reveal an elevated proliferation of BrdU(+) cells in SVZ following subchronic manganese (Mn) exposure in rats. This study was designed to distinguish Mn effect on the critical stage of adult neurogenesis, ie, proliferation, migration, survival and differentiation from the SVZ via the rostral migratory stream to the olfactory bulb (OB). Adult rats received a single ip-dose of BrdU at the end of 4-week Mn exposure to label proliferating cells. Immunostaining and cell-counting showed a 48% increase of BrdU(+) cells in Mn-exposed SVZ than in controls (Padult rats received 3 daily ip-injections of BrdU followed by subchronic Mn exposure. By 4-week post BrdU labeling, most of the surviving BrdU(+) cells in the OB were differentiated into NeuN(+) matured neurons. However, survival rates of BrdU/NeuN/DAPI triple-labeled cells in OB were 33% and 64% in Mn-exposed and control animals, respectively (Padult SVZ. In the OB, however, Mn exposure significantly reduces the surviving adult-born cells and markedly inhibits their differentiation into mature neurons, resulting in an overall decreased adult neurogenesis in the OB. PMID:26794142

  20. Imaging and recording subventricular zone progenitor cells in live tissue of postnatal mice

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    Benjamin Lacar

    2010-07-01

    Full Text Available The subventricular zone (SVZ is one of two regions where neurogenesis persists in the postnatal brain. The SVZ, located along the lateral ventricle, is the largest neurogenic zone in the brain that contains multiple cell populations including astrocyte-like cells and neuroblasts. Neuroblasts migrate in chains to the olfactory bulb where they differentiate into interneurons. Here, we discuss the experimental approaches to record the electrophysiology of these cells and image their migration and calcium activity in acute slices. Although these techniques were in place for studying glial cells and neurons in mature networks, the SVZ raises new challenges due to the unique properties of SVZ cells, the cellular diversity, and the architecture of the region. We emphasize different methods, such as the use of transgenic mice and in vivo electroporation that permit identification of the different SVZ cell populations for patch clamp recording or imaging. Electroporation also permits genetic labeling of cells using fluorescent reporter mice and modification of the system using either RNA interference technology or floxed mice. In this review, we aim to provide conceptual and technical details of the approaches to perform electrophysiological and imaging studies of SVZ cells.

  1. Notch1 Signaling Modulates Neuronal Progenitor Activity in the Subventricular Zone in Response to Aging and Focal Ischemia

    OpenAIRE

    Sun, Fen; Mao, XiaoOu; Xie, Lin; Ding, Meiping; Shao, Bei; Jin, Kunlin

    2013-01-01

    Neurogenesis diminishes with aging and ischemia-induced neurogenesis also occurs, but reduced in aged brain. Currently, the cellular and molecular pathways mediating these effects remain largely unknown. Our previous study has shown that Notch1 signaling regulates neurogenesis in subventricular zone (SVZ) of young-adult brain after focal ischemia, but whether a similar effect occurs in aged normal and ischemic animals is unknown. Here, we used normal and ischemic aged rat br...

  2. Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases

    OpenAIRE

    Maki, Takakuni; Liang, Anna C.; Miyamoto, Nobukazu; Lo, Eng H.; Arai, Ken

    2013-01-01

    White matter dysfunction is an important part of many CNS disorders including multiple sclerosis (MS) and vascular dementia. Within injured areas, myelin loss and oligodendrocyte death may trigger endogenous attempts at regeneration. However, during disease progression, remyelination failure may eventually occur due to impaired survival/proliferation, migration/recruitment, and differentiation of oligodendrocyte precursor cells (OPCs). The ventricular-subventricular zone (V-SVZ) and the subgr...

  3. Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases

    OpenAIRE

    Ken Arai

    2013-01-01

    White matter dysfunction is an important part of many CNS disorders including multiple sclerosis and vascular dementia. Within injured areas, myelin loss and oligodendrocyte death may trigger endogenous attempts at regeneration. However, during disease progression, remyelination failure may eventually occur due to impaired survival/proliferation, migration/recruitment, and differentiation of oligodendrocyte precursor cells (OPCs). The ventricular-subventricular zone (V-SVZ) and the subgranula...

  4. The Association of Subventricular Zone Involvement at Recurrence with Survival after Repeat Surgery in Patients with Recurrent Glioblastoma

    OpenAIRE

    Sonoda, Yukihiko; Saito, Ryuta; Kanamori, Masayuki; Kumabe, Toshihiro; UENOHARA, Hiroshi; TOMINAGA, Teiji

    2013-01-01

    Surgical resection is identified as an important prognostic factor for survival in patients undergoing initial resection of glioblastoma (GBM). However, in patients with tumor recurrence, the benefits of repeat surgery remain unclear. Recent reports have stated that the association between initial surgery for GBM and subventricular zone (SVZ) influences survival. The current study examined the relationship of SVZ involvement in recurrent GBM to survival time after reoperation. We conducted a ...

  5. Inflammation-induced subventricular zone dysfunction leads to olfactory deficits in a targeted mouse model of multiple sclerosis.

    OpenAIRE

    Tepavčević, Vanja; Lazarini, Françoise; Alfaro-Cervello, Clara; Kerninon, Christophe; Yoshikawa, Kazuaki; Garcia-Verdugo, José Manuel; Lledo, Pierre-Marie; Nait-Oumesmar, Brahim; Baron-Van Evercooren, Anne

    2011-01-01

    International audience Neural stem cells (NSCs) persist in defined brain niches, including the subventricular zone (SVZ), throughout adulthood and generate new neurons destined to support specific neurological functions. Whether brain diseases such as multiple sclerosis (MS) are associated with changes in adult NSCs and whether this might contribute to the development and/or persistence of neurological deficits remains poorly investigated. We examined SVZ function in mice in which we targe...

  6. Trimethyltin intoxication induces the migration of ventricular/subventricular zone cells to the injured murine hippocampus.

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    Weig, Blair C; Richardson, Jason R; Lowndes, Herbert E; Reuhl, Kenneth R

    2016-05-01

    Following the postnatal decline of cell proliferation in the mammalian central nervous system, the adult brain retains progenitor cells with stem cell-like properties in the subventricular zone (SVZ) and the subgranular zone (SGZ) of the hippocampus. Brain injury can stimulate proliferation and redirect the migration pattern of SVZ precursor cells to the injury site. Sublethal exposure to the neurotoxicant trimethyltin (TMT) causes dose-dependent necrosis and apoptosis in the hippocampus dentate gyrus and increases SGZ stem cell proliferation to generate new granule cells. To determine whether SVZ cells also contribute to the repopulation of the TMT-damaged dentate gyrus, 6-8 week old male C3H mice were injected with the carbocyanine dye spDiI and bromodeoxyuridine (80mg/kg; ip.) to label ventricular cells prior to TMT exposure. The presence of labeled cells in hippocampus was determined 7 and 28days after TMT exposure. No significant change in the number of BrdU(+) and spDiI(+) cells was observed in the dentate gyrus 7days after TMT treatment. However, 28days after TMT treatment there was a 3-4 fold increase in the number of spDiI-labeled cells in the hippocampal hilus and dentate gyrus. Few spDiI(+) cells stained positive for the mature phenotypic markers NeuN or GFAP, suggesting they may represent undifferentiated cells. A small percentage of migrating cells were BrdU(+)/spDiI(+), indicating some newly produced, SVZ- derived precursors migrated to the hippocampus. Taken together, these data suggest that TMT-induced injury of the hippocampus can stimulate the migration of ventricular zone-derived cells to injured dentate gyrus. PMID:27045884

  7. NMDA modulates oligodendrocyte differentiation of subventricular zone cells through PKC activation

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    Fabio eCavaliere

    2013-12-01

    Full Text Available Multipotent cells from the juvenile subventricular zone (SVZ possess the ability to differentiate into new neural cells. Depending on local signals, SVZ can generate new neurons, astrocytes or oligodendrocytes. We previously demonstrated that activation of NMDA receptors in SVZ progenitors increases the rate of oligodendrocyte differentiation. Here we investigated the mechanisms involved in NMDA receptor-dependent differentiation. Using functional studies performed with the reporter gene luciferase we found that activation of NMDA receptor stimulates PKC. In turn, stimulation of PKC precedes the activation of NADPH oxidase (NOX as demonstrated by translocation of the p67phox subunit to the cellular membrane. We propose that NOX2 is involved in the transduction of the signal from NMDA receptors through PKC activation as the inhibitor gp91 reduced their pro-differentiation effect. In addition, our data and that from other groups suggest that signaling through the NMDA receptor/PKC/NOX2 cascade generates ROS that activate the PI3/mTOR pathway and finally leads to the generation of new oligodendrocytes.

  8. Chromatin-based epigenetics of adult subventricular zone neural stem cells

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    Gabriel eGonzales-Roybal

    2013-10-01

    Full Text Available In specific regions of the adult mammalian brain, neural stem cells (NSCs generate new neurons throughout life. Emerging evidence indicate that chromatin-based transcriptional regulation is a key epigenetic mechanism for the life-long function of adult NSCs. In the adult mouse brain, NSCs in the subventricular zone (SVZ retain the ability to produce both neurons and glia for the life of the animal. In this review, we discuss the origin and function of SVZ NSCs as they relate to key epigenetic concepts of development and potential underlying mechanism of chromatin-based transcriptional regulation. A central point of discussion is how SVZ NSCs – which possess many characteristics of mature, non-neurogenic astrocytes – maintain a youthful ability to produce both neuronal and glial lineages. In addition to reviewing data regarding the function of chromatin-modifying factors in SVZ neurogenesis, we incorporate our growing understanding that long noncoding RNAs (lncRNAs serve as an important element to chromatin-based transcriptional regulation, including that of SVZ NSCs. Discoveries regarding the epigenetic mechanisms of adult SVZ NSCs may provide key insights into fundamental principles of adult stem cell biology as well as the more complex and dynamic developmental environment of the embryonic brain.

  9. The Adult Ventricular-Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis.

    Science.gov (United States)

    Lim, Daniel A; Alvarez-Buylla, Arturo

    2016-01-01

    A large population of neural stem/precursor cells (NSCs) persists in the ventricular-subventricular zone (V-SVZ) located in the walls of the lateral brain ventricles. V-SVZ NSCs produce large numbers of neuroblasts that migrate a long distance into the olfactory bulb (OB) where they differentiate into local circuit interneurons. Here, we review a broad range of discoveries that have emerged from studies of postnatal V-SVZ neurogenesis: the identification of NSCs as a subpopulation of astroglial cells, the neurogenic lineage, new mechanisms of neuronal migration, and molecular regulators of precursor cell proliferation and migration. It has also become evident that V-SVZ NSCs are regionally heterogeneous, with NSCs located in different regions of the ventricle wall generating distinct OB interneuron subtypes. Insights into the developmental origins and molecular mechanisms that underlie the regional specification of V-SVZ NSCs have also begun to emerge. Other recent studies have revealed new cell-intrinsic molecular mechanisms that enable lifelong neurogenesis in the V-SVZ. Finally, we discuss intriguing differences between the rodent V-SVZ and the corresponding human brain region. The rapidly expanding cellular and molecular knowledge of V-SVZ NSC biology provides key insights into postnatal neural development, the origin of brain tumors, and may inform the development regenerative therapies from cultured and endogenous human neural precursors. PMID:27048191

  10. Neurotoxic effects of ochratoxin A on the subventricular zone of adult mouse brain.

    Science.gov (United States)

    Paradells, Sara; Rocamonde, Brenda; Llinares, Cristina; Herranz-Pérez, Vicente; Jimenez, Misericordia; Garcia-Verdugo, Jose Manuel; Zipancic, Ivan; Soria, Jose Miguel; Garcia-Esparza, Ma Angeles

    2015-07-01

    Ochratoxin A (OTA), a mycotoxin that was discovered as a secondary metabolite of the fungal species Aspergillus and Penicillium, is a common contaminant in food and animal feed. This mycotoxin has been described as teratogenic, carcinogenic, genotoxic, immunotoxic and has been proven a potent neurotoxin. Other authors have previously reported the effects of OTA in different structures of the central nervous system as well as in some neurogenic regions. However, the impact of OTA exposure in the subventricular zone (SVZ) has not been assessed yet. To elucidate whether OTA affects neural precursors of the mouse SVZ we investigated, in vitro and in vivo, the effects of OTA exposure on the SVZ and on the neural precursors obtained from this neurogenic niche. In this work, we prove the cumulative effect of OTA exposure on proliferation, differentiation and depletion of neural stem cells cultured from the SVZ. In addition, we corroborated these results in vivo by immunohistochemistry and electron microscopy. As a result, we found a significant alteration in the proliferation process, which was evidenced by a decrease in the number of 5-bromo-2-deoxyuridine-positive cells and glial cells, as well as, a significant decrease in the number of neuroblasts in the SVZ. To summarize, in this study we demonstrate how OTA could be a threat to the developing and the adult SVZ through its impact in cell viability, proliferation and differentiation in a dose-dependent manner. PMID:25256750

  11. Anatomical Involvement of the Subventricular Zone Predicts Poor Survival Outcome in Low-Grade Astrocytomas.

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    Shuai Liu

    Full Text Available The subventricular zone (SVZ has been implicated in the origination, development, and biological behavior of gliomas. Tumor-SVZ contact is also postulated to be a poor prognostic factor in glioblastomas. We aimed to evaluate the prognostic consequence of the anatomical involvement of low-grade gliomas with the SVZ. To that end, we reviewed 143 patients with diffuse astrocytomas, and tumor lesions were manually delineated on magnetic resonance images. We initially investigated the prognostic role of SVZ contact in all patients. Additionally, we investigated the influence of the anatomical proximity of the tumor lesion centroids to the SVZ in the SVZ-involved patient cohorts, as well as location within the SVZ. We found SVZ contact with tumors to be a significant prognostic factor of overall survival in all patients with diffuse astrocytomas (p = 0.027. In the SVZ-involved cohort, a shorter distance from the tumor centroid to the SVZ (≤30 mm correlated with shorter overall survival (p = 0.022 on univariate analysis. However, there was no significant difference in overall survival with respect to the SVZ region involved with the tumor (p = 0.930. Multivariate analysis showed that a shorter distance between the tumor centroid and the SVZ (p = 0.039 was significantly associated with poor overall survival in SVZ-involved patients. Hence, this study helps establish the prognostic role of the anatomical interaction of tumors with the SVZ in low-grade astrocytomas.

  12. Experiment study of single low dose irradiation on subventricular zone cell

    International Nuclear Information System (INIS)

    Objective: To study the effects of whole brain irradiation on subventricular zone cells (SVZ) in juvenile rat. Methods: Six-week-old Wistar rats, whose brains are still growing, were irradiated with single dose of 1 Gy X-ray. Their body and brain weight were measured at days 30 or 60 after irradiation. The chronological changes of the SVZ were examined at 6 h, days 7, 14, 30 or 60 after irradiation by immunohistochemistry specifically to observe the neural stem cell using anti-nestin antibodies specific for these cells. Results: The rate of brain weight gain of irradiated rats significantly decreased in comparison to controls, although that of body weight gain was similar among them. Multiple apoptotic cell appeared in the SVZ at 6 h after irradiation with simultaneous reduction in nestin-positive cell (69% of the control). The cell levels recovered within a week, with the nestin-positive cells reaching maximal (180%) on day 14, returned to baseline levels within 30 days (96%) and remained unchanged for subsequent 60 days. Conclusions: Single low-dose X-ray administration reversibly affected the levels of neural stem cells in the SVZ region. The result suggest that continuous multiple administration of X-ray in clinical treatment may induce irreversible changes on neural stem cells, and cause brain growth retardation or dysfunction. (authors)

  13. New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesis.

    Directory of Open Access Journals (Sweden)

    Maria Francisca eEiriz

    2014-06-01

    Full Text Available The subventricular zone (SVZ contains neural stem cells (NSCs that generate new neurons throughout life. Many brain diseases stimulate NSCs proliferation, neuronal differentiation and homing of these newborns cells into damaged regions. However, complete cell replacement has never been fully achieved. Hence, the identification of proneurogenic factors crucial for stem cell-based therapies will have an impact in brain repair. Histamine, a neurotransmitter and immune mediator, has been recently described to modulate proliferation and commitment of NSCs. Histamine levels are increased in the brain parenchyma and at the cerebrospinal fluid (CSF upon inflammation and brain injury, thus being able to modulate neurogenesis. Herein, we add new data showing that in vivo administration of histamine in the lateral ventricles has a potent proneurogenic effect, increasing the production of new neuroblasts in the SVZ that ultimately reach the olfactory bulb (OB. This report emphasizes the multidimensional effects of histamine in the modulation of NSCs dynamics and sheds light into the promising therapeutic role of histamine for brain regenerative medicine.

  14. PDGF-responsive progenitors persist in the subventricular zone across the lifespan

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    Lisamarie Moore

    2014-02-01

    Full Text Available The SVZ (subventricular zone contains neural stem cells and progenitors of various potentialities. Although initially parsed into A, B, and C cells, this germinal zone is comprised of a significantly more diverse population of cells. Here, we characterized a subset of postnatal PRPs (PDGF-AA-responsive precursors that express functional PDGFα and β receptors from birth to adulthood. When grown in PDGF-AA, dissociated neonatal rat SVZ cells divided to produce non-adherent clusters of progeny. Unlike the self-renewing EGF/FGF-2-responsive precursors that produce neurospheres, these PRPs failed to self-renew after three passages; therefore, we refer to the colonies they produce as spheroids. Upon differentiation these spheroids could produce neurons, type 1 astrocytes and oligodendrocytes. When maintained in medium supplemented with BMP-4 they also produced type 2 astrocytes. Using lineage tracing methods, it became evident that there were multiple types of PRPs, including a subset that could produce neurons, oligodendrocytes, and type 1 and type 2 astrocytes; thus some of these PRPs represent a unique population of precursors that are quatropotential. Spheroids also could be generated from the newborn neocortex and they had the same potentiality as those from the SVZ. By contrast, the adult neocortex produced less than 20% of the numbers of spheroids than the adult SVZ and spheroids from the adult neocortex only differentiated into glial cells. Interestingly, SVZ spheroid producing capacity diminished only slightly from birth to adulthood. Altogether these data demonstrate that there are PRPs that persist in the SVZ that includes a unique population of quatropotential PRPs.

  15. Characterization of Seeding Conditions for Studies on Differentiation Patterns of Subventricular Zone Derived Neurospheres.

    Science.gov (United States)

    Sanchez-Mendoza, Eduardo H; Schlechter, Jana; Hermann, Dirk M; Doeppner, Thorsten R

    2016-01-01

    Stem cell research depends on extensive in vitro research. Poly-D-lysine (PDL) and polyornithine (PornT) are chemically synthesized amino acid chains promoting cell adhesion to solid substrates. Although, PDL and PornT are extensively used, there is no common agreement regarding the most optimal substance and its concentration. We therefore aimed at testing the effect of increasing concentrations (10, 50, and 100 μg/ml) for each compound and their corresponding mixtures (5+5 and 10+10 μg/ml) on the differentiation patterns of subventricular zone derived neurospheres. The latter were cultured for 24 h for protein and morphological analysis or for 8 h for migration analysis. No significant differences were found between increasing concentrations of PDL and PornT alone and the 10+10 condition in Western blots and immunocytochemistry. However, the mixed condition of 5+5 showed decreased glial fibrillary acidic protein and nestin expression with no changes in Akt, pAkt, GSK-3-beta, and pGSK-3-beta expression patterns. The various coating conditions also had no influence on migration of cells emerging from the neurosphere. Nevertheless, stimulation with recombinant human Erythropoietin (rhEpo) reduced migration by 20% regardless of the coating condition. We therefore conclude that a minimal concentration of 10 μg/ml of either compound should be used to produce reliable results with no alterations in protein levels as found for the 5+5 groups, and that the coating has no effect on the response of cells to chemical interventions. As such, a concentration of 10 μg/ml for either substance is sufficient when studying cellular processes of neurospheres in an in vitro or ex vivo environment. PMID:27013970

  16. Characterization of seeding conditions for studies on differentiation patterns of subventricular zone derived neurospheres

    Directory of Open Access Journals (Sweden)

    Eduardo H Sanchez-Mendoza

    2016-03-01

    Full Text Available Stem cell research depends on extensive in vitro research. Poly-D-Lysine (PDL and Polyornithine (PornT are chemically synthesized amino acid chains promoting cell adhesion to solid substrates. Although PDL and PornT are extensively used, there is no common agreement regarding the most optimal substance and its concentration. We therefore aimed at testing the effect of increasing concentrations (10, 50 and 100 µg/ml for each compound and their corresponding mixtures (5+5 and 10+10 µg/ml on the differentiation patterns of subventricular zone derived neurospheres. The latter were cultured for 24 h for protein and morphological analysis or for 8h for migration analysis. No significant differences were found between increasing concentrations of PDL and PornT alone and the 10+10 condition in Western blots and immunocytochemistry. However, the mixed condition of 5+5 showed decreased GFAP and nestin expression with no changes in Akt, pAkt, GSK-3-beta and pGSK-3-beta expression patterns. The various coating conditions also had no influence on migration of cells emerging from the neurosphere. Nevertheless, stimulation with recombinant human Erythropoietin (rhEpo reduced migration by 20% regardless of the coating condition. We therefore conclude that a minimal concentration of 10 µg/ml of either compound should be used to produce reliable results with no alterations in protein levels as found for the 5+5 group, and that the coating has no effect on the response of cells to chemical interventions. As such, a concentration of 10 µg/ml for either substance is sufficient when studying cellular processes of neurospheres in an in vitro or ex vivo environment.

  17. Glioblastoma Recurrence Patterns After Radiation Therapy With Regard to the Subventricular Zone

    Energy Technology Data Exchange (ETDEWEB)

    Adeberg, Sebastian, E-mail: Sebastian.adeberg@med.uni-heidelberg [Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg (Germany); König, Laila; Bostel, Tilman; Harrabi, Semi; Welzel, Thomas [Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg (Germany); Debus, Jürgen [Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg (Germany); Heidelberg Ion Therapy Center, Heidelberg (Germany); DKFZ Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center Heidelberg (Germany); Combs, Stephanie E. [Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg (Germany); Heidelberg Ion Therapy Center, Heidelberg (Germany)

    2014-11-15

    Purpose: We evaluated the influence of tumor location and tumor spread in primary glioblastoma (GBM), with respect to the subventricular zone (SVZ), on recurrence behavior, progression-free survival (PFS), and overall survival (OS). Methods and Materials: 607 patients (376 male and 231 female) with a median age of 61.3 years (range, 3.0-87.9 years) and primary GBM treated with radiation therapy (RT) from 2004 to 2012 at a single institution were included in this retrospective study. Preoperative images and follow-up examination results were assessed to evaluate tumor location. Tumors were classified according to the tumor location in relation to the SVZ. Results: The median PFS of the study population was 5.2 months (range, 1-91 months), and the median OS was 13.8 months (range, 1-102 months). Kaplan-Meier analysis showed that tumor location in close proximity to the SVZ was associated with a significant decline in PFS and OS (4.8 and 12.3 months, respectively; each P<.001). Furthermore, in cases where tumors were involved with the SVZ, distant cerebral progression (43.8%; P=.005) and multifocal progression (39.8%; P=.008) were more common. Interestingly, opening of the ventricle during the previous surgery showed no impact on PFS and OS. Conclusion: GBM in close proximity to the SVZ was associated with decreased survival and had a higher risk of multifocal or distant progression. Ventricle opening during surgery had no effect on survival rates.

  18. Glioblastoma Recurrence Patterns After Radiation Therapy With Regard to the Subventricular Zone

    International Nuclear Information System (INIS)

    Purpose: We evaluated the influence of tumor location and tumor spread in primary glioblastoma (GBM), with respect to the subventricular zone (SVZ), on recurrence behavior, progression-free survival (PFS), and overall survival (OS). Methods and Materials: 607 patients (376 male and 231 female) with a median age of 61.3 years (range, 3.0-87.9 years) and primary GBM treated with radiation therapy (RT) from 2004 to 2012 at a single institution were included in this retrospective study. Preoperative images and follow-up examination results were assessed to evaluate tumor location. Tumors were classified according to the tumor location in relation to the SVZ. Results: The median PFS of the study population was 5.2 months (range, 1-91 months), and the median OS was 13.8 months (range, 1-102 months). Kaplan-Meier analysis showed that tumor location in close proximity to the SVZ was associated with a significant decline in PFS and OS (4.8 and 12.3 months, respectively; each P<.001). Furthermore, in cases where tumors were involved with the SVZ, distant cerebral progression (43.8%; P=.005) and multifocal progression (39.8%; P=.008) were more common. Interestingly, opening of the ventricle during the previous surgery showed no impact on PFS and OS. Conclusion: GBM in close proximity to the SVZ was associated with decreased survival and had a higher risk of multifocal or distant progression. Ventricle opening during surgery had no effect on survival rates

  19. Identification and culture of neural stem cells isolated from adult rat subventricular zone following fluid percussion brain injury

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Objective To analyze proliferation and differentiation of glial fibrillary acid protein(GFAP)-and nestin-positive(GFAP+/nestin+)cells isolated from the subventricular zone following fluid percussion brain injury to determine whether GFAP+/nestin+ cells exhibit characteristics of neural stem cells.Methods Male Sprague-Dawley rats,aged 12 weeks and weighing 200-250 g,were randomly and evenly assigned to normal control group and model group.In the model group,a rat model of fluid percussion brain injury was es...

  20. Increased Subventricular Zone Radiation Dose Correlates With Survival in Glioblastoma Patients After Gross Total Resection

    International Nuclear Information System (INIS)

    Purpose: Neural progenitor cells in the subventricular zone (SVZ) have a controversial role in glioblastoma multiforme (GBM) as potential tumor-initiating cells. The purpose of this study was to examine the relationship between radiation dose to the SVZ and survival in GBM patients. Methods and Materials: The study included 116 patients with primary GBM treated at the Johns Hopkins Hospital between 2006 and 2009. All patients underwent surgical resection followed by adjuvant radiation therapy with intensity modulated radiation therapy (60 Gy/30 fractions) and concomitant temozolomide. Ipsilateral, contralateral, and bilateral SVZs were contoured on treatment plans by use of coregistered magnetic resonance imaging and computed tomography. Multivariate Cox regression was used to examine the relationship between mean SVZ dose and progression-free survival (PFS), as well as overall survival (OS). Age, Karnofsky Performance Status score, and extent of resection were used as covariates. The median age was 58 years (range, 29-80 years). Results: Of the patients, 12% underwent biopsy, 53% had subtotal resection (STR), and 35% had gross total resection (GTR). The Karnofsky Performance Status score was less than 90 in 54 patients and was 90 or greater in 62 patients. The median ipsilateral, contralateral, and bilateral mean SVZ doses were 48.7 Gy, 34.4 Gy, and 41.5 Gy, respectively. Among patients who underwent GTR, a mean ipsilateral SVZ dose of 40 Gy or greater was associated with a significantly improved PFS compared with patients who received less than 40 Gy (15.1 months vs 10.3 months; P=.028; hazard ratio, 0.385 [95% confidence interval, 0.165-0.901]) but not in patients undergoing STR or biopsy. The subgroup of GTR patients who received an ipsilateral dose of 40 Gy or greater also had a significantly improved OS (17.5 months vs 15.6 months; P=.027; hazard ratio, 0.385 [95% confidence interval, 0.165-0.895]). No association was found between SVZ radiation dose and PFS

  1. Increased Subventricular Zone Radiation Dose Correlates With Survival in Glioblastoma Patients After Gross Total Resection

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Linda [Department of Neurosurgery, The Johns Hopkins University, Baltimore, Maryland (United States); Duke University School of Medicine, Durham, North Carolina (United States); Guerrero-Cazares, Hugo [Department of Neurosurgery, The Johns Hopkins University, Baltimore, Maryland (United States); Ye, Xiaobu [Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University, Baltimore, Maryland (United States); Ford, Eric [Department of Radiation Oncology, University of Washington, Seattle, Washington (United States); McNutt, Todd; Kleinberg, Lawrence [Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University, Baltimore, Maryland (United States); Lim, Michael; Chaichana, Kaisorn [Department of Neurosurgery, The Johns Hopkins University, Baltimore, Maryland (United States); Quinones-Hinojosa, Alfredo, E-mail: aquinon2@jhmi.edu [Department of Neurosurgery, The Johns Hopkins University, Baltimore, Maryland (United States); Redmond, Kristin, E-mail: kjanson3@jhmi.edu [Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University, Baltimore, Maryland (United States)

    2013-07-15

    Purpose: Neural progenitor cells in the subventricular zone (SVZ) have a controversial role in glioblastoma multiforme (GBM) as potential tumor-initiating cells. The purpose of this study was to examine the relationship between radiation dose to the SVZ and survival in GBM patients. Methods and Materials: The study included 116 patients with primary GBM treated at the Johns Hopkins Hospital between 2006 and 2009. All patients underwent surgical resection followed by adjuvant radiation therapy with intensity modulated radiation therapy (60 Gy/30 fractions) and concomitant temozolomide. Ipsilateral, contralateral, and bilateral SVZs were contoured on treatment plans by use of coregistered magnetic resonance imaging and computed tomography. Multivariate Cox regression was used to examine the relationship between mean SVZ dose and progression-free survival (PFS), as well as overall survival (OS). Age, Karnofsky Performance Status score, and extent of resection were used as covariates. The median age was 58 years (range, 29-80 years). Results: Of the patients, 12% underwent biopsy, 53% had subtotal resection (STR), and 35% had gross total resection (GTR). The Karnofsky Performance Status score was less than 90 in 54 patients and was 90 or greater in 62 patients. The median ipsilateral, contralateral, and bilateral mean SVZ doses were 48.7 Gy, 34.4 Gy, and 41.5 Gy, respectively. Among patients who underwent GTR, a mean ipsilateral SVZ dose of 40 Gy or greater was associated with a significantly improved PFS compared with patients who received less than 40 Gy (15.1 months vs 10.3 months; P=.028; hazard ratio, 0.385 [95% confidence interval, 0.165-0.901]) but not in patients undergoing STR or biopsy. The subgroup of GTR patients who received an ipsilateral dose of 40 Gy or greater also had a significantly improved OS (17.5 months vs 15.6 months; P=.027; hazard ratio, 0.385 [95% confidence interval, 0.165-0.895]). No association was found between SVZ radiation dose and PFS

  2. Subcellular distribution of N-methyl-D-aspartic acid receptor subunit 1 in neural stem cells within subventricular zone of adult rats

    Institute of Scientific and Technical Information of China (English)

    Zhining Li; Wenlong Lü; Hongyan Dong; Hongbin Fan; Ruiguo Dong; Tiejun Xu

    2011-01-01

    The subcellular localization of N-methyl-D-aspartic acid receptor subunit 1 in neural stem cells of the subventricular zone of adult rats was detected using electron microscopy, following immunohistochemistry and immunogold-silver double staining. Results confirmed the presence of neural stem cells in the subventricular zone, which is a key neurogenic region in the central nervous system of adult mammals. The expression of N-methyl-D-aspartic acid receptor subunit 1 was higher than that of nestin and mainly distributed in the cell membrane, cytoplasm, rough endoplasmic reticulum and Golgi complex of neural stem cells.

  3. Reduced proliferation in the adult mouse subventricular zone increases survival of olfactory bulb interneurons.

    Directory of Open Access Journals (Sweden)

    Yi Sui

    Full Text Available Neurogenesis in the adult brain is largely restricted to the subependymal zone (SVZ of the lateral ventricle, olfactory bulb (OB and the dentate subgranular zone, and survival of adult-born cells in the OB is influenced by factors including sensory experience. We examined, in mice, whether survival of adult-born cells is also regulated by the rate of precursor proliferation in the SVZ. Precursor proliferation was decreased by depleting the SVZ of dopamine after lesioning dopamine neurons in the substantia nigra compacta with 6-hydroxydopamine. Subsequently, we examined the effect of reduced SVZ proliferation on the generation, migration and survival of neuroblasts and mature adult-born cells in the SVZ, rostral migratory stream (RMS and OB. Proliferating cells in the SVZ, measured by 5-bromo-2-deoxyuridine (BrdU injected 2 hours prior to death or by immunoreactivity against Ki67, were reduced by 47% or 36%, respectively, 7 days after dopamine depletion, and by 29% or 31% 42 days after dopamine depletion, compared to sham-treated animals. Neuroblast generation in the SVZ and their migration along the RMS were not affected, neither 7 nor 42 days after the 6-hydroxydopamine injection, since the number of doublecortin-immunoreactive neuroblasts in the SVZ and RMS, as well as the number of neuronal nuclei-immunoreactive cells in the OB, were stable compared to control. However, survival analysis 15 days after 6-hydroxydopamine and 6 days after BrdU injections showed that the number of BrdU+ cells in the SVZ was 70% higher. Also, 42 days after 6-hydroxydopamine and 30 days after BrdU injections, we found an 82% increase in co-labeled BrdU+/γ-aminobutyric acid-immunoreactive cell bodies in the granular cell layer, while double-labeled BrdU+/tyrosine hydroxylase-immunoreactive cell bodies in the glomerular layer increased by 148%. We conclude that the number of OB interneurons following reduced SVZ proliferation is maintained through an increased

  4. Altered speeds and trajectories of neurons migrating in the ventricular and subventricular zones of the reeler neocortex.

    Science.gov (United States)

    Britto, Joanne M; Tait, Karen J; Johnston, Leigh A; Hammond, Vicki E; Kalloniatis, Michael; Tan, Seong-Seng

    2011-05-01

    The Reelin signaling pathway is essential for proper cortical development, but it is unclear to whether Reelin function is primarily important for cortical layering or neuron migration. It has been proposed that Reelin is perhaps required only for somal translocation but not glial-dependent locomotion. This implies that the location of neurons responding to Reelin is restricted to the outer regions of the cortical plate (CP). To determine whether Reelin is required for migration outside of the CP, we used time-lapse imaging to track the behavior of cells undergoing locomotion in the germinal zones. We focused on the migratory activity in the ventricular/subventricular zones where the first transition of bipolar to multipolar migration occurs and where functional Reelin receptors are known to be expressed. Despite Reelin loss, neurons had no difficulty in undergoing radial migration and indeed displayed greater migratory speed. Additionally, compared with the wild-type, reeler neurons displayed altered trajectories with greater deviation from a radial path. These results suggest that Reelin loss has early consequences for migration in the germinal zones that are portrayed as defective radial trajectories and migratory speeds. Together, these abnormalities can give rise to the increased cell dispersion observed in the reeler cortex. PMID:20847150

  5. Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases

    Directory of Open Access Journals (Sweden)

    Ken Arai

    2013-12-01

    Full Text Available White matter dysfunction is an important part of many CNS disorders including multiple sclerosis and vascular dementia. Within injured areas, myelin loss and oligodendrocyte death may trigger endogenous attempts at regeneration. However, during disease progression, remyelination failure may eventually occur due to impaired survival/proliferation, migration/recruitment, and differentiation of oligodendrocyte precursor cells (OPCs. The ventricular-subventricular zone (V-SVZ and the subgranular zone are the main sources of neural stem/progenitor cells (NSPCs, which can give rise to neurons as well as OPCs. Under normal conditions in the adult brain, the V-SVZ progenitors generate a large number of neurons with a small number of oligodendrocyte lineage cells. However, after demyelination, the fate of V-SVZ-derived progenitor cells shifts from neurons to OPCs, and these newly generated OPCs migrate to the demyelinating lesions to ease white matter damage. In this mini-review, we will summarize the recent studies on extrinsic (e.g., vasculature, extracellular matrix, cerebrospinal fluid and intrinsic (e.g., transcription factors, epigenetic modifiers factors, which mediate oligodendrocyte generation from the V-SVZ progenitor cells. A deeper understanding of the mechanisms that regulate the fate of V-SVZ progenitor cells may lead to new therapeutic approaches for ameliorating white matter dysfunction and damage in CNS disorders.

  6. Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases

    Science.gov (United States)

    Maki, Takakuni; Liang, Anna C.; Miyamoto, Nobukazu; Lo, Eng H.; Arai, Ken

    2013-01-01

    White matter dysfunction is an important part of many CNS disorders including multiple sclerosis (MS) and vascular dementia. Within injured areas, myelin loss and oligodendrocyte death may trigger endogenous attempts at regeneration. However, during disease progression, remyelination failure may eventually occur due to impaired survival/proliferation, migration/recruitment, and differentiation of oligodendrocyte precursor cells (OPCs). The ventricular-subventricular zone (V-SVZ) and the subgranular zone (SGZ) are the main sources of neural stem/progenitor cells (NSPCs), which can give rise to neurons as well as OPCs. Under normal conditions in the adult brain, the V-SVZ progenitors generate a large number of neurons with a small number of oligodendrocyte lineage cells. However, after demyelination, the fate of V-SVZ-derived progenitor cells shifts from neurons to OPCs, and these newly generated OPCs migrate to the demyelinating lesions to ease white matter damage. In this mini-review, we will summarize the recent studies on extrinsic (e.g., vasculature, extracellular matrix (ECM), cerebrospinal fluid (CSF)) and intrinsic (e.g., transcription factors, epigenetic modifiers) factors, which mediate oligodendrocyte generation from the V-SVZ progenitor cells. A deeper understanding of the mechanisms that regulate the fate of V-SVZ progenitor cells may lead to new therapeutic approaches for ameliorating white matter dysfunction and damage in CNS disorders. PMID:24421755

  7. The multifaceted subventricular zone astrocyte: From a metabolic and pro-neurogenic role to acting as a neural stem cell.

    Science.gov (United States)

    Platel, J C; Bordey, A

    2016-05-26

    A few decades ago it was discovered that two regions of the adult brain retain the ability to generate new neurons. These regions include the subgranular zone of the hippocampal dentate gyrus and the ventricular-subventricular zone (V-SVZ) located at the border of the lateral ventricle. In the V-SVZ, it was discovered that neural progenitor cells (NPCs) share many features of mature astrocytes and are often referred as V-SVZ astrocytes. We will first describe the markers, the morphology, and the neurophysiological characteristics of the mouse V-SVZ astrocytes. We will then discuss the fact that V-SVZ astrocytes constitute a mixed population with respect to their neurogenic properties, e.g., quiescent versus activated state, neurogenic fate, and transcription factors expression. Finally, we will describe two functions of V-SVZ astrocytes, their metabolic coupling to blood vessels and their neurogenic-supportive role consisting of providing guidance and survival cues to migrating newborn neurons. PMID:26546469

  8. P2X7 Receptor Inhibition Increases CNTF in the Subventricular Zone, But Not Neurogenesis or Neuroprotection After Stroke in Adult Mice

    OpenAIRE

    Kang, Seong Su; Keasey, Matthew Phillip; Hagg, Theo

    2013-01-01

    Increasing endogenous ciliary neurotrophic factor (CNTF) expression with a pharmacological agent might be beneficial after stroke as CNTF both promotes neurogenesis and, separately, is neuroprotective. P2X7 purinergic receptor inhibition is neuroprotective in rats and increases CNTF release in rat CMT1A Schwann cells. We, first, investigated the role of P2X7 in regulating CNTF and neurogenesis in adult mouse subventricular zone (SVZ). CNTF expression was increased by daily intravenous injecti...

  9. Hyperbaric oxygen treatment promotes neural stem cell proliferation in the subventricular zone of neonatal rats with hypoxic-ischemic brain damage

    Institute of Scientific and Technical Information of China (English)

    Zhichun Feng; Jing Liu; Rong Ju

    2013-01-01

    Hyperbaric oxygen therapy for the treatment of neonatal hypoxic-ischemic brain damage has been used clinically for many years, but its effectiveness remains controversial. In addition, the mechanism of this potential neuroprotective effect remains unclear. This study aimed to investigate the influence of hyperbaric oxygen on the proliferation of neural stem cells in the subventricular zone of neonatal Sprague-Dawley rats (7 days old) subjected to hypoxic-ischemic brain damage. Six hours after modeling, rats were treated with hyperbaric oxygen once daily for 7 days. Immunohistochemistry revealed that the number of 5-bromo-2′-deoxyuridine positive and nestin positive cells in the subventricular zone of neonatal rats increased at day 3 after hypoxic-ischemic brain damage and peaked at day 5. After hyperbaric oxygen treatment, the number of 5-bromo-2′- deoxyuridine positive and nestin positive cells began to increase at day 1, and was significantly higher than that in normal rats and model rats until day 21. Hematoxylin-eosin staining showed that hyperbaric oxygen treatment could attenuate pathological changes to brain tissue in neonatal rats, and reduce the number of degenerating and necrotic nerve cells. Our experimental findings indicate that hyperbaric oxygen treatment enhances the proliferation of neural stem cells in the subventricular zone of neonatal rats with hypoxic-ischemic brain damage, and has therapeutic potential for promoting neurological recovery following brain injury.

  10. The 9-O-acetyl GD3 gangliosides are expressed by migrating chains of subventricular zone neurons in vitro

    Directory of Open Access Journals (Sweden)

    Miyakoshi L.M.

    2001-01-01

    Full Text Available Neurons from the anterior subventricular zone (SVZ of the cerebral cortex migrate tangentially to become interneurons in the olfactory bulb during development and in adult rodents. This migration was defined as neuronophilic, independent of a radial glial substrate. The cortical SVZ and the rostral migratory stream to the olfactory bulb were shown to be rich in 9-O-acetyl GD3 gangliosides (9-O-acGD3, which have been previously shown to be implicated in gliophilic migration in the rodent cerebral cortex and cerebellum. In the present study, we performed SVZ explant cultures using rats during their first postnatal week to analyze the expression of these gangliosides in chain migration of neuronal precursors. We characterized migrating chains of these neuroblasts through morphological analysis and immunocytochemistry for the neural cell adhesion molecule. By using the Jones monoclonal antibody which binds specifically to 9-O-acGD3 we showed that migrating chains from the SVZ explants express 9-O-acGD3 which is distributed in a punctate manner in individual cells. 9-O-acGD3 is also present in migrating chains that form in the absence of radial glia, typical of the neuronophilic chain migration of the SVZ. Our data indicate that 9-O-acetylated gangliosides may participate in neuronophilic as well as gliophilic migration.

  11. Indomethacin treatment reduces microglia activation and increases numbers of neuroblasts in the subventricular zone and ischaemic striatum after focal ischaemia

    Indian Academy of Sciences (India)

    ROSANA S LOPES; MARCELO M CARDOSO; ARTHUR O SAMPAIO; MARIO SANTOS BARBOSA Jr; CELICE C SOUZA; MICHELLE C DA SILVA; ELANE MAGNO N FERREIRA; MARCO AURELIOM FREIRE; RAFAEL RODRIGUES LIMA; WALACE GOMES-LEAL

    2016-09-01

    Neuroblasts from the subventricular zone (SVZ) migrate to striatum following stroke, but most of them die inthe ischaemic milieu and this can be related to exacerbated microglial activation. Here, we explored theeffects of the non-steroidal anti-inflammatory indomethacin on microglial activation, neuronal preservation andneuroblast migration following experimental striatal stroke in adult rats. Animals were submitted toendothelin-1 (ET-1)-induced focal striatal ischaemia and were treated with indomethacin or sterile saline(i.p.) for 7 days, being perfused after 8 or 14 days. Immunohistochemistry was performed to assess neuronalloss (anti-NeuN), microglial activation (anti-Iba1, ED1) and migrating neuroblasts (anti-DCX) by countingNeuN, ED1 and DCX-positive cells in the ischaemic striatum or SVZ. Indomethacin treatment reducedmicroglia activation and the number of ED1^{+} cells in both 8 and 14 days post injury as compared withcontrols. There was an increase in the number of DCX^{+} cells in both SVZ and striatum at the same survivaltimes. Moreover, there was a decrease in the number of NeuN^{+} cells in indomethacin-treated animals ascompared with the control group at 8 days but not after 14 days post injury. Our results suggest thatindomethacin treatment modulates microglia activation, contributing to increased neuroblast proliferation inthe SVZ and migration to the ischaemic striatum following stroke.

  12. A comparative study of the structural organization of spheres derived from the adult human subventricular zone and glioblastoma biopsies

    International Nuclear Information System (INIS)

    Sphere forming assays have been useful to enrich for stem like cells in a range of tumors. The robustness of this system contrasts the difficulties in defining a stem cell population based on cell surface markers. We have undertaken a study to describe the cellular and organizational composition of tumorspheres, directly comparing these to neurospheres derived from the adult human subventricular zone (SVZ). Primary cell cultures from brain tumors were found to contain variable fractions of cells positive for tumor stem cell markers (CD133 (2-93%)/SSEA1 (3-15%)/CXCR4 (1-72%)). All cultures produced tumors upon xenografting. Tumorspheres contained a heterogeneous population of cells, but were structurally organized with stem cell markers present at the core of spheres, with markers of more mature glial progenitors and astrocytes at more peripheral location. Ultrastructural studies showed that tumorspheres contained a higher fraction of electron dense cells in the core than the periphery (36% and 19%, respectively). Neurospheres also contained a heterogeneous cell population, but did not have an organization similar to tumorspheres. Although tumorspheres clearly display irregular and neoplastic cells, they establish an organized structure with an outward gradient of differentiation. We suggest that this organization is central in maintaining the tumor stem cell pool.

  13. In vivo and ex vivo magnetic resonance spectroscopy of the infarct and the subventricular zone in experimental stroke

    Science.gov (United States)

    Jiménez-Xarrié, Elena; Davila, Myriam; Gil-Perotín, Sara; Jurado-Rodríguez, Andrés; Candiota, Ana Paula; Delgado-Mederos, Raquel; Lope-Piedrafita, Silvia; García-Verdugo, José Manuel; Arús, Carles; Martí-Fàbregas, Joan

    2015-01-01

    Ex vivo high-resolution magic-angle spinning (HRMAS) provides metabolic information with higher sensitivity and spectral resolution than in vivo magnetic resonance spectroscopy (MRS). Therefore, we used both techniques to better characterize the metabolic pattern of the infarct and the neural progenitor cells (NPCs) in the ipsilateral subventricular zone (SVZi). Ischemic stroke rats were divided into three groups: G0 (non-stroke controls, n=6), G1 (day 1 after stroke, n=6), and G7 (days 6 to 8 after stroke, n=12). All the rats underwent MRS. Three rats per group were analyzed by HRMAS. The remaining rats were used for immunohistochemical studies. In the infarct, both techniques detected significant metabolic changes. The most relevant change was in mobile lipids (2.80 ppm) in the G7 group (a 5.53- and a 3.95-fold increase by MRS and HRMAS, respectively). In the SVZi, MRS did not detect any significant metabolic change. However, HRMAS detected a 2.70-fold increase in lactate and a 0.68-fold decrease in N-acetylaspartate in the G1 group. None of the metabolites correlated with the 1.37-fold increase in NPCs detected by immunohistochemistry in the G7 group. In conclusion, HRMAS improves the metabolic characterization of the brain in experimental ischemic stroke. However, none of the metabolites qualifies as a surrogate biomarker of NPCs. PMID:25605287

  14. Gypenosides Protected the Neural Stem Cells in the Subventricular Zone of Neonatal Rats that Were Prenatally Exposed to Ethanol

    Directory of Open Access Journals (Sweden)

    Lun Dong

    2014-11-01

    Full Text Available Fetal alcohol spectrum disorder (FASD can cause severe mental retardation in children who are prenatally exposed to ethanol. The effects of prenatal and early postnatal ethanol exposure on adult hippocampal neurogenesis have been investigated; however, the effects of prenatal ethanol exposure on the subventricular zone (SVZ have not. Gypenosides (GPs have been reported to have neuroprotective effects in addition to other bioactivities. The effects of GPs on neural stem cells (NSCs in the FASD model are unknown. Here, we test the effect of prenatal ethanol exposure on the neonatal SVZ, and the protection potential of GPs on NSCs in FASD rats. Our results show that prenatal ethanol exposure can suppress the cell proliferation and differentiation of neural stem cells in the neonatal SVZ and that GPs (400 mg/kg/day can significantly increase the cell proliferation and differentiation of neural stem cells inhibited by ethanol. Our data indicate that GPs have neuroprotective effects on the NSCs and can enhance the neurogenesis inhibited by ethanol within the SVZ of neonatal rats. These findings provide new evidence for a potential therapy involving GPs for the treatment of FASD.

  15. Anosmin-1 over-expression increases adult neurogenesis in the subventricular zone and neuroblast migration to the olfactory bulb.

    Science.gov (United States)

    García-González, Diego; Murcia-Belmonte, Verónica; Esteban, Pedro F; Ortega, Felipe; Díaz, David; Sánchez-Vera, Irene; Lebrón-Galán, Rafael; Escobar-Castañondo, Laura; Martínez-Millán, Luis; Weruaga, Eduardo; García-Verdugo, José Manuel; Berninger, Benedikt; de Castro, Fernando

    2016-01-01

    New subventricular zone (SVZ)-derived neuroblasts that migrate via the rostral migratory stream are continuously added to the olfactory bulb (OB) of the adult rodent brain. Anosmin-1 (A1) is an extracellular matrix protein that binds to FGF receptor 1 (FGFR1) to exert its biological effects. When mutated as in Kallmann syndrome patients, A1 is associated with severe OB morphogenesis defects leading to anosmia and hypogonadotropic hypogonadism. Here, we show that A1 over-expression in adult mice strongly increases proliferation in the SVZ, mainly with symmetrical divisions, and produces substantial morphological changes in the normal SVZ architecture, where we also report the presence of FGFR1 in almost all SVZ cells. Interestingly, for the first time we show FGFR1 expression in the basal body of primary cilia in neural progenitor cells. Additionally, we have found that A1 over-expression also enhances neuroblast motility, mainly through FGFR1 activity. Together, these changes lead to a selective increase in several GABAergic interneuron populations in different OB layers. These specific alterations in the OB would be sufficient to disrupt the normal processing of sensory information and consequently alter olfactory memory. In summary, this work shows that FGFR1-mediated A1 activity plays a crucial role in the continuous remodelling of the adult OB. PMID:25300351

  16. Severe instead of mild hyperglycemia inhibits neurogenesis in the subventricular zone of adult rats after transient focal cerebral ischemia.

    Science.gov (United States)

    Tan, S; Zhi, P K; Luo, Z K; Shi, J

    2015-09-10

    Accumulated evidence suggests that enhanced neurogenesis stimulated by ischemic injury contributes to stroke outcome. However, it is unclear whether hyperglycemia, which is frequently tested positive in patients with acute ischemic stroke, influences stroke-induced neurogenesis. The aim of the present study is to examine the effect of hyperglycemia on stroke-induced neurogenesis in a rat model of transient focal cerebral ischemia. For this purpose, adult male Sprague-Dawley rats (220-250 g) were subjected to 90 min of middle cerebral artery occlusion (MCAO). Glucose was administered during ischemia to produce target blood levels ranging from 4.83 ± 0.94 mM (normoglycemia) to 20.76 ± 1.56 mM. To label proliferating cells in ischemic ipsilateral subventricular zone (SVZ) of lateral ventricles, 5'-bromo-2'-deoxyuridine (BrdU) was injected 24h after MCAO. Brains were harvested 2h post-BrdU to evaluate the effects of hyperglycemia on infarct volume and SVZ cell proliferation. Rats that were severely hyperglycemic (19.26 ± 1.48 mM to 20.76 ± 1.56 mM) during ischemia had 24.26% increase in infarct volume (Pneurogenesis by a mechanism involving suppression of CREB and BDNF signaling. PMID:26126927

  17. Changes of evoked potential and expression of nestin in subventricular zones in rats after focal cerebral ischemia

    Institute of Scientific and Technical Information of China (English)

    GAO Jie; WANG Yong-tang; WANG Li-li; ZENG Ling; WU Ya-min; SHAO Yang

    2007-01-01

    Objective:To study the characteristics of latency of somatosensory evoked potential (SEP)and motor evoked potential (MEP) and the expression of nestin in subventricular zones (SVZ) after persistent focal cerebral ischemia in rats. Methods: The model of cerebral ischemia in rats was made by middle cerebral artery occlusion (MCAO). All animals of ischemia were sacrificed after 12 h, 1 d, 3 d, 7 d,and 14 d to observe the changes of latency of SEP and MEP and to detect the expression of nestin, with an immunohistochemical approach. Results: The latencies of P1 (positive wave 1), N1 (negative wave 1) and P2 (positive wave 2) in SEP were significantly prolonged after MCAO. The latencies of N1 and N2 waves in MEP were postponed gradually and no statistical difference of latency of N1 wave was found in rats at 7d and 14 d after MCAO. The expression of nestin increased at 12 h, and showed a significant augmentation at 3 d and peaked at 7 d, then declined slightly at 14 d after MCAO. Conclusion: The cerebral ischemia prolonged the latency of EP waves and the expression of nestin was up-regulated and reached the peak at 7d, showing the ischemia induced the proliferation of nervous stem cells. The SEP and MEP may evaluate the proliferation in SVZ after brain ischemia.

  18. Identification and characterization of neuroblasts in the subventricular zone and rostral migratory stream of the adult human brain

    Institute of Scientific and Technical Information of China (English)

    Congmin Wang; Qiangqiang Zhang; Yue Zhang; Rui Chen; Hongjun Song; Zhengang Yang; Fang Liu; Ying-Ying Liu; Cai-Hong Zhao; Yan You; Lei Wang; Jingxiao Zhang; Bin Wei; Tong Ma

    2011-01-01

    It is of great interest to identify new neurons in the adult human brain,but the persistence of neurogenesis in the subventricular zone (SVZ) and the existence of the rostral migratory stream (RMS)-like pathway in the adult human forebrain remain highly controversial.In the present study,we have described the general configuration of the RMS in adult monkey,fetal human and adult human brains.We provide evidence that neuroblasts exist continuously in the anterior ventral SVZ and RMS of the adult human brain.The neuroblasts appear singly or in pairs without forming chains; they exhibit migratory morphologies and co-express the immature neuronal markers doublecortin,polysialylated neural cell adhesion molecule and βI-tubulin.Few of these neuroblasts appear to be actively proliferating in the anterior ventral SVZ but none in the RMS,indicating that neuroblasts distributed along the RMS are most likely derived from the ventral SVZ.Interestingly,no neuroblasts are found in the adult human olfactory bulb.Taken together,our data suggest that the SVZ maintains the ability to produce neuroblasts in the adult human brain.

  19. A comparative study of the structural organization of spheres derived from the adult human subventricular zone and glioblastoma biopsies

    Energy Technology Data Exchange (ETDEWEB)

    Vik-Mo, Einar Osland, E-mail: e.o.vik-mo@medisin.uio.no [Vilhelm Magnus Laboratory for Neurosurgical Research, Institute for Surgical Research, Oslo University Hospital, Oslo (Norway); Department of Neurosurgery, Oslo University Hospital, Oslo (Norway); Sandberg, Cecilie [Vilhelm Magnus Laboratory for Neurosurgical Research, Institute for Surgical Research, Oslo University Hospital, Oslo (Norway); Joel, Mrinal [Vilhelm Magnus Laboratory for Neurosurgical Research, Institute for Surgical Research, Oslo University Hospital, Oslo (Norway); Department of Physiology, Institute of Basic Medical Sciences, University of Oslo (Norway); Stangeland, Biljana [Vilhelm Magnus Laboratory for Neurosurgical Research, Institute for Surgical Research, Oslo University Hospital, Oslo (Norway); Watanabe, Yasuhiro [Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago 683-8504 (Japan); Mackay-Sim, Alan [National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, QLD 4111 (Australia); Moe, Morten Carstens [Center for Eye Research, Department of Ophthalmology, Oslo University Hospital, Oslo (Norway); Murrell, Wayne [Vilhelm Magnus Laboratory for Neurosurgical Research, Institute for Surgical Research, Oslo University Hospital, Oslo (Norway); Langmoen, Iver Arne [Vilhelm Magnus Laboratory for Neurosurgical Research, Institute for Surgical Research, Oslo University Hospital, Oslo (Norway); Department of Neurosurgery, Oslo University Hospital, Oslo (Norway)

    2011-04-15

    Sphere forming assays have been useful to enrich for stem like cells in a range of tumors. The robustness of this system contrasts the difficulties in defining a stem cell population based on cell surface markers. We have undertaken a study to describe the cellular and organizational composition of tumorspheres, directly comparing these to neurospheres derived from the adult human subventricular zone (SVZ). Primary cell cultures from brain tumors were found to contain variable fractions of cells positive for tumor stem cell markers (CD133 (2-93%)/SSEA1 (3-15%)/CXCR4 (1-72%)). All cultures produced tumors upon xenografting. Tumorspheres contained a heterogeneous population of cells, but were structurally organized with stem cell markers present at the core of spheres, with markers of more mature glial progenitors and astrocytes at more peripheral location. Ultrastructural studies showed that tumorspheres contained a higher fraction of electron dense cells in the core than the periphery (36% and 19%, respectively). Neurospheres also contained a heterogeneous cell population, but did not have an organization similar to tumorspheres. Although tumorspheres clearly display irregular and neoplastic cells, they establish an organized structure with an outward gradient of differentiation. We suggest that this organization is central in maintaining the tumor stem cell pool.

  20. Congenitally acquired persistent lymphocytic choriomeningitis viral infection reduces neuronal progenitor pools in the adult hippocampus and subventricular zone.

    Directory of Open Access Journals (Sweden)

    Tony Sun

    Full Text Available Lymphocytic choriomeningitis virus (LCMV can be transmitted through congenital infection, leading to persistent infection of numerous organ systems including the central nervous system (CNS. Adult mice persistently infected with LCMV (LCMV-cgPi mice exhibit learning deficits, such as poor performance in spatial discrimination tests. Given that deficits in spatial learning have been linked to defects in adult neurogenesis, we investigated the impact of congenital LCMV infection on generation of neuroblasts from neural progenitor cells within neurogenic zones of adult mice. In LCMV-cgPi mice, QPCR and immunohistochemistry detected presence of LCMV glycoprotein-coding RNA and nucleoprotein in the hippocampal dentate gyrus and subventricular zone (SVZ, sites of neurogenesis that harbor populations of neuroblasts. Numbers of neuroblasts were reduced in LCMV-cgPi mice, as determined by IHC quantification, and analysis of BrdU incorporation by flow cytometry revealed lower numbers of BrdU-labeled neuroblasts. Additionally, TUNEL assays performed in situ showed increased numbers of apoptotic cells in the two neurogenic regions. Next, neurosphere cultures were infected in vitro with LCMV and differentiated to create a population of cells that consisted of both transit amplifying cells and neuroblasts. Immunocytochemical and TUNEL assays revealed increased numbers of TUNEL-positive cells that express nestin, suggesting that the drop in numbers of neuroblasts was due to a combination of impaired proliferation and apoptosis of progenitor cells. LCMV-cgPi mice exhibited transcriptional up-regulation several cytokines and chemokines, including gamma-interferon inducible chemokines CXCL9 and CXCL10. Chronic up-regulation of these chemokines can facilitate a pro-inflammatory niche that may contribute to defects in neurogenesis.

  1. SSEA-4 and YKL-40 positive progenitor subtypes in the subventricular zone of developing human neocortex

    DEFF Research Database (Denmark)

    Brøchner, Christian B; Møllgård, Kjeld

    2016-01-01

    The glycosphingolipid SSEA-4 and the glycoprotein YKL-40 have both been associated with human embryonic and neural stem cell differentiation. We investigated the distribution of SSEA-4 and YKL-40 positive cells in proliferative zones of human fetal forebrain using immunohistochemistry and double...... characterized by immunohistochemical combination of antibodies against SSEA-4 and YKL-40 and devoid of neuronal and microglial markers represent a yet unexplored astrogenic lineage illustrating the complexity of astroglial development. GLIA 2015....

  2. S phase entry of neural progenitor cells correlates with increased blood flow in the young subventricular zone.

    Directory of Open Access Journals (Sweden)

    Benjamin Lacar

    Full Text Available The postnatal subventricular zone (SVZ contains proliferating neural progenitor cells in close proximity to blood vessels. Insults and drug treatments acutely stimulate cell proliferation in the SVZ, which was assessed by labeling cells entering S phase. Although G1-to-S progression is metabolically demanding on a minute-to-hour time scale, it remains unknown whether increased SVZ cell proliferation is accompanied by a local hemodynamic response. This neurovascular coupling provides energy substrates to active neuronal assemblies. Transcardial dye perfusion revealed the presence of capillaries throughout the SVZ that constrict upon applications of the thromboxane A(2 receptor agonist U-46119 in acute brain slice preparations. We then monitored in vivo blood flow using laser Doppler flowmetry via a microprobe located either in the SVZ or a mature network. U-46119 injections into the lateral ventricle decreased blood flow in the SVZ and the striatum, which are near the ventricle. A 1-hour ventricular injection of epidermal and basic fibroblast growth factor (EGF and bFGF significantly increased the percentage of Sox2 transcription factor-positive cells in S phase 1.5 hours post-injection. This increase was accompanied by a sustained rise in blood flow in the SVZ but not in the striatum. Direct growth factor injections into the cortex did not alter local blood flow, ruling out direct effects on capillaries. These findings suggest that an acute increase in the number of G1-to-S cycling SVZ cells is accompanied by neurometabolic-vascular coupling, which may provide energy and nutrient for cell cycle progression.

  3. PPARβ/δ and PPARγ maintain undifferentiated phenotypes of mouse adult neural precursor cells from the subventricular zone.

    Science.gov (United States)

    Bernal, Carolina; Araya, Claudia; Palma, Verónica; Bronfman, Miguel

    2015-01-01

    The subventricular zone (SVZ) is one of the main niches of neural stem cells in the adult mammalian brain. Stem and precursor cells in this region are the source for neurogenesis and oligodendrogesis, mainly in the olfactory bulb and corpus callosum, respectively. The identification of the molecular components regulating the decision of these cells to differentiate or maintain an undifferentiated state is important in order to understand the modulation of neurogenic processes in physiological and pathological conditions. PPARs are a group of transcription factors, activated by lipid ligands, with important functions in cellular differentiation and proliferation in several tissues. In this work, we demonstrate that mouse adult neural precursor cells (NPCs), in situ and in vitro, express PPARβ/δ and PPARγ. Pharmacological activation of both PPARs isoforms induces proliferation and maintenance of the undifferentiated phenotype. Congruently, inhibition of PPARβ/δ and PPARγ results in a decrease of proliferation and loss of the undifferentiated phenotype. Interestingly, PPARγ regulates the level of EGFR in adult NPCs, concurrent with it is function described in embryonic NPCs. Furthermore, we describe for the first time that PPARβ/δ regulates SOX2 level in adult NPCs, probably through a direct transcriptional regulation, as we identified two putative PPAR response elements in the promoter region of Sox2. EGFR and SOX2 are key players in neural stem/precursor cells self-renewal. Finally, rosiglitazone, a PPARγ ligand, increases PPARβ/δ level, suggesting a possible cooperation between these two PPARs in the control of cell fate behavior. Our work contributes to the understanding of the molecular mechanisms associated to neural cell fate decision and places PPARβ/δ and PPARγ as interesting new targets of modulation of mammalian brain homeostasis. PMID:25852474

  4. Activation of type 1 cannabinoid receptor (CB1R promotes neurogenesis in murine subventricular zone cell cultures.

    Directory of Open Access Journals (Sweden)

    Sara Xapelli

    Full Text Available The endocannabinoid system has been implicated in the modulation of adult neurogenesis. Here, we describe the effect of type 1 cannabinoid receptor (CB1R activation on self-renewal, proliferation and neuronal differentiation in mouse neonatal subventricular zone (SVZ stem/progenitor cell cultures. Expression of CB1R was detected in SVZ-derived immature cells (Nestin-positive, neurons and astrocytes. Stimulation of the CB1R by (R-(+-Methanandamide (R-m-AEA increased self-renewal of SVZ cells, as assessed by counting the number of secondary neurospheres and the number of Sox2+/+ cell pairs, an effect blocked by Notch pathway inhibition. Moreover, R-m-AEA treatment for 48 h, increased proliferation as assessed by BrdU incorporation assay, an effect mediated by activation of MAPK-ERK and AKT pathways. Surprisingly, stimulation of CB1R by R-m-AEA also promoted neuronal differentiation (without affecting glial differentiation, at 7 days, as shown by counting the number of NeuN-positive neurons in the cultures. Moreover, by monitoring intracellular calcium concentrations ([Ca(2+]i in single cells following KCl and histamine stimuli, a method that allows the functional evaluation of neuronal differentiation, we observed an increase in neuronal-like cells. This proneurogenic effect was blocked when SVZ cells were co-incubated with R-m-AEA and the CB1R antagonist AM 251, for 7 days, thus indicating that this effect involves CB1R activation. In accordance with an effect on neuronal differentiation and maturation, R-m-AEA also increased neurite growth, as evaluated by quantifying and measuring the number of MAP2-positive processes. Taken together, these results demonstrate that CB1R activation induces proliferation, self-renewal and neuronal differentiation from mouse neonatal SVZ cell cultures.

  5. Adult mouse subventricular zone stem and progenitor cells are sessile and epidermal growth factor receptor negatively regulates neuroblast migration.

    Directory of Open Access Journals (Sweden)

    Yongsoo Kim

    Full Text Available BACKGROUND: The adult subventricular zone (SVZ contains stem and progenitor cells that generate neuroblasts throughout life. Although it is well accepted that SVZ neuroblasts are migratory, recent evidence suggests their progenitor cells may also exhibit motility. Since stem and progenitor cells are proliferative and multipotential, if they were also able to move would have important implications for SVZ neurogenesis and its potential for repair. METHODOLOGY/PRINCIPAL FINDINGS: We studied whether SVZ stem and/or progenitor cells are motile in transgenic GFP+ slices with two photon time lapse microscopy and post hoc immunohistochemistry. We found that stem and progenitor cells; mGFAP-GFP+ cells, bright nestin-GFP+ cells and Mash1+ cells were stationary in the SVZ and rostral migratory stream (RMS. In our search for motile progenitor cells, we uncovered a population of motile betaIII-tubulin+ neuroblasts that expressed low levels of epidermal growth factor receptor (EGFr. This was intriguing since EGFr drives proliferation in the SVZ and affects migration in other systems. Thus we examined the potential role of EGFr in modulating SVZ migration. Interestingly, EGFr(low neuroblasts moved slower and in more tortuous patterns than EGFr-negative neuroblasts. We next questioned whether EGFr stimulation affects SVZ cell migration by imaging Gad65-GFP+ neuroblasts in the presence of transforming growth factor alpha (TGF-alpha, an EGFr-selective agonist. Indeed, acute exposure to TGF-alpha decreased the percentage of motile cells by approximately 40%. CONCLUSIONS/SIGNIFICANCE: In summary, the present study directly shows that SVZ stem and progenitor cells are static, that EGFr is retained on some neuroblasts, and that EGFr stimulation negatively regulates migration. This result suggests an additional role for EGFr signaling in the SVZ.

  6. Neural progenitor cells isolated from the subventricular zone present hemichannel activity and form functional gap junctions with glial cells

    Science.gov (United States)

    Talaverón, Rocío; Fernández, Paola; Escamilla, Rosalba; Pastor, Angel M.; Matarredona, Esperanza R.; Sáez, Juan C.

    2015-01-01

    The postnatal subventricular zone (SVZ) lining the walls of the lateral ventricles contains neural progenitor cells (NPCs) that generate new olfactory bulb interneurons. Communication via gap junctions between cells in the SVZ is involved in NPC proliferation and in neuroblast migration towards the olfactory bulb. SVZ NPCs can be expanded in vitro in the form of neurospheres that can be used for transplantation purposes after brain injury. We have previously reported that neurosphere-derived NPCs form heterocellular gap junctions with host glial cells when they are implanted after mechanical injury. To analyze functionality of NPC-glial cell gap junctions we performed dye coupling experiments in co-cultures of SVZ NPCs with astrocytes or microglia. Neurosphere-derived cells expressed mRNA for at least the hemichannel/gap junction channel proteins connexin 26 (Cx26), Cx43, Cx45 and pannexin 1 (Panx1). Dye coupling experiments revealed that gap junctional communication occurred among neurosphere cells (incidence of coupling: 100%). Moreover, hemichannel activity was also detected in neurosphere cells as evaluated in time-lapse measurements of ethidium bromide uptake. Heterocellular coupling between NPCs and glial cells was evidenced in co-cultures of neurospheres with astrocytes (incidence of coupling: 91.0 ± 4.7%) or with microglia (incidence of coupling: 71.9 ± 6.7%). Dye coupling in neurospheres and in co-cultures was inhibited by octanol, a gap junction blocker. Altogether, these results suggest the existence of functional hemichannels and gap junction channels in postnatal SVZ neurospheres. In addition, they demonstrate that SVZ-derived NPCs can establish functional gap junctions with astrocytes or microglia. Therefore, cell-cell communication via gap junctions and hemichannels with host glial cells might subserve a role in the functional integration of NPCs after implantation in the damaged brain. PMID:26528139

  7. Chronic treatment with fluoxetine for more than 6 weeks decreases neurogenesis in the subventricular zone of adult mice

    Directory of Open Access Journals (Sweden)

    Ohira Koji

    2011-03-01

    Full Text Available Abstract Background Recent studies indicate that chronic treatment with serotonergic antidepressants upregulates adult neurogenesis of the dentate gyrus (DG. In contrast, some studies claimed that there was very little alteration of neurogenesis in the subventricular zone (SVZ by the antidepressants. Since almost all of those studies treated animals with drugs for 2 to 4 weeks as chronic treatment models of antidepressants, it is possible that antidepressant treatments for longer periods would affect adult neurogenesis in the SVZ. Results In the present study, we examined the effects of long-term (up to 9 weeks administration of fluoxetine (FLX, a selective serotonin reuptake inhibitor, on cell proliferation and survival in the DG and the SVZ of adult mice. As reported previously, in the DG of mice treated with FLX for 3, 6, or 9 weeks that were also injected with 5-bromodeoxyuridine (BrdU in the last 3 days before perfusion, the numbers of Ki67- and BrdU-positive cells, which are cell proliferation markers, were significantly upregulated even at 3 weeks after the onset of the FLX treatments, and these increases were sustained in mice treated with FLX for 9 weeks. On the other hand, in the SVZ, we found a small, insignificant decrease in the numbers of Ki67- and BrdU-positive cells at 3 weeks, followed by highly significant decreases in the numbers of Ki67- and BrdU-positive cells at both 6 and 9 weeks. Furthermore, among olfactory newly generated cells that survived for 3 weeks after BrdU injection, the number of new cells was decreased at 9 weeks of FLX treatment. Conclusions These results demonstrate that long-term (more than 6 weeks treatment with FLX has the opposite effect on neurogenesis in the SVZ than it does in the DG. The results also suggest that the decrease in neurogenesis in the SVZ might be involved in some aspects of the drugs' therapeutic effects on depression. In addition, our findings raise the possibility that some of the

  8. Age-related neurogenesis decline in the subventricular zone is associated with specific cell cycle regulation changes in activated neural stem cells.

    Science.gov (United States)

    Daynac, Mathieu; Morizur, Lise; Chicheportiche, Alexandra; Mouthon, Marc-André; Boussin, François D

    2016-01-01

    Although neural stem cells (NSCs) sustain continuous neurogenesis throughout the adult lifespan of mammals, they progressively exhibit proliferation defects that contribute to a sharp reduction in subventricular neurogenesis during aging. However, little is known regarding the early age-related events in neurogenic niches. Using a fluorescence-activated cell sorting technique that allows for the prospective purification of the main neurogenic populations from the subventricular zone (SVZ), we demonstrated an early decline in adult neurogenesis with a dramatic loss of progenitor cells in 4 month-old young adult mice. Whereas the activated and quiescent NSC pools remained stable up to 12 months, the proliferative status of activated NSCs was already altered by 6 months, with an overall extension of the cell cycle resulting from a specific lengthening of G1. Whole genome analysis of activated NSCs from 2- and 6-month-old mice further revealed distinct transcriptomic and molecular signatures, as well as a modulation of the TGFβ signalling pathway. Our microarray study constitutes a cogent identification of new molecular players and signalling pathways regulating adult neurogenesis and its early modifications. PMID:26893147

  9. Metallic gold treatment reduces proliferation of inflammatory cells, increases expression of VEGF and FGF, and stimulates cell proliferation in the subventricular zone following experimental traumatic brain injury

    DEFF Research Database (Denmark)

    Pedersen, Mie Østergaard; Larsen, Agnete; Pedersen, Dan Sonne;

    2009-01-01

    gold implants reduce inflammation and neuronal apoptosis, while generating an increased neuronal stem cell response following focal brain damage. In this study mice were subjected to a unilateral traumatic cryo-lesion with concomitant injection of 25-45 microm gold particles near the lesion. Placebo......-treated mice subjected to cryo-lesion served as controls. The effects of gold-treatment were investigated by examining gold-induced growth factor expression (VEGF and FGF) in the first two weeks after the insult, and the extent of the neurostimulatory effect of gold was explored by comparing cell proliferation...... a significant increase in cell proliferation in both the ipsilateral and the contralateral subventricular zone was found in response to gold-treatment. In conclusion: we confirmed the previously demonstrated anti-inflammatory effect of bio-liberated gold ions, and further show that metallic gold...

  10. Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson's disease.

    Science.gov (United States)

    Bertilsson, Göran; Patrone, Cesare; Zachrisson, Olof; Andersson, Annica; Dannaeus, Karin; Heidrich, Jessica; Kortesmaa, Jarkko; Mercer, Alex; Nielsen, Elisabet; Rönnholm, Harriet; Wikström, Lilian

    2008-02-01

    We investigated the effects of exendin-4 on neural stem/progenitor cells in the subventricular zone of the adult rodent brain and its functional effects in an animal model of Parkinson's disease. Our results showed expression of GLP-1 receptor mRNA or protein in the subventricular zone and cultured neural stem/progenitor cells isolated from this region. In vitro, exendin-4 increased the number of neural stem/progenitor cells, and the number of cells expressing the neuronal markers microtubule-associated protein 2, beta-III-tubulin, and neuron-specific enolase. When exendin-4 was given intraperitoneally to naïve rodents together with bromodeoxyuridine, a marker for DNA synthesis, both the number of bromodeoxyuridine-positive cells and the number of neuronal precursor cells expressing doublecortin were increased. Exendin-4 was tested in the 6-hydroxydopamine model of Parkinson's disease to investigate its possible functional effects in an animal model with neuronal loss. After unilateral lesion and a 5-week stabilization period, the rats were treated for 3 weeks with exendin-4. We found a reduction of amphetamine-induced rotations in animals receiving exendin-4 that persisted for several weeks after drug administration had been terminated. Histological analysis showed that exendin-4 significantly increased the number of both tyrosine hydroxylase- and vesicular monoamine transporter 2-positive neurons in the substantia nigra. In conclusion, our results show that exendin-4 is able to promote adult neurogenesis in vitro and in vivo, normalize dopamine imbalance, and increase the number of cells positive for markers of dopaminergic neurons in the substantia nigra in a model of Parkinson's disease. PMID:17803225

  11. RE1 silencing transcription factor/neuron-restrictive silencing factor regulates expansion of adult mouse subventricular zone-derived neural stem/progenitor cells in vitro.

    Science.gov (United States)

    Soldati, Chiara; Caramanica, Pasquale; Burney, Matthew J; Toselli, Camilla; Bithell, Angela; Augusti-Tocco, Gabriella; Stanton, Lawrence W; Biagioni, Stefano; Buckley, Noel J; Cacci, Emanuele

    2015-08-01

    Adult neural stem cell (aNSC) activity is tuned by external stimuli through the recruitment of transcription factors. This study examines the RE1 silencing transcription factor (REST) in neural stem/progenitor cells isolated from the subventricular zone of adult mouse brain and provides the first extensive characterization of REST-mediated control of the cellular and molecular properties. This study shows that REST knockdown affects the capacity of progenitor cells to generate neurospheres, reduces cell proliferation, and triggers cell differentiation despite the presence of growth factors. Genome- and transcriptome-wide analyses show that REST binding sites are significantly enriched in genes associated with synaptic transmission and nervous system development and function. Seeking candidate regulators of aNSC function, this study identifies a member of the bone morphogenetic protein (BMP) family, BMP6, the mRNA and protein of which increased after REST knockdown. The results of this study extend previous findings, demonstrating a reciprocal control of REST expression by BMPs. Administration of exogenous BMP6 inhibits aNSC proliferation and induces the expression of the astrocytic marker glial fibrillary acidic protein, highlighting its antimitogenic and prodifferentiative effects. This study suggests that BMP6 produced in a REST-regulated manner together with other signals can contribute to regulation of NSC maintenance and fate. PMID:25691247

  12. Neuroprotection by Exendin-4 Is GLP-1 Receptor Specific but DA D3 Receptor Dependent, Causing Altered BrdU Incorporation in Subventricular Zone and Substantia Nigra

    Directory of Open Access Journals (Sweden)

    A. Harkavyi

    2013-01-01

    Full Text Available Glucagon-like peptide-1 receptor (GLP-1R activation by exendin-4 (EX-4 is effective in preclinical models of Parkinson’s disease (PD and appears to promote neurogenesis even in severely lesioned rats. In the present study, we determined the effects of EX-4 on cellular BrdU incorporation in the rat subventricular zone (SVZ and substantia nigra (SN. We also determined the specificity of this effect with the GLP-1R antagonist EX-(9-39 as well as the potential role of dopamine (DA D3 receptors. Rats were administered 6-OHDA and 1 week later given EX-4 alone, with EX-(9-39 or nafadotride (D3 antagonist and BrdU. Seven days later, rats were challenged with apomorphine to evaluate circling. Extracellular DA was measured using striatal microdialysis and subsequently tissue DA measured. Tyrosine hydroxylase and BrdU were verified using immunohistochemistry. Apomorphine circling was reversed by EX-4 in lesioned rats, an effect reduced by EX-4, while both EX-(9-39 and NAF attenuated this. 6-OHDA decreased extracellular and tissue DA, both reversed by EX-4 but again attenuated by EX-(9-39 or NAF. Analysis of BrdU+ cells in the SVZ revealed increases in 6-OHDA-treated rats which were reversed by EX-4 and antagonised by either EX-(9-39 or NAF, while in the SN the opposite profile was seen.

  13. The Effect of Pro-Neurogenic Gene Expression on Adult Subventricular Zone Precursor Cell Recruitment and Fate Determination After Excitotoxic Brain Injury

    Science.gov (United States)

    Jones, Kathryn S; Connor, Bronwen J

    2016-01-01

    Despite the presence of on-going neurogenesis in the adult mammalian brain, neurons are generally not replaced after injury. Using a rodent model of excitotoxic cell loss and retroviral (RV) lineage tracing, we previously demonstrated transient recruitment of precursor cells from the subventricular zone (SVZ) into the lesioned striatum. In the current study we determined that these cells included migratory neuroblasts and oligodendrocyte precursor cells (OPC), with the predominant response from glial cells. We attempted to override this glial response by ectopic expression of the pro-neurogenic genes Pax6 or Dlx2 in the adult rat SVZ following quinolinic acid lesioning. RV-Dlx2 over-expression stimulated repair at a previously non-neurogenic time point by enhancing neuroblast recruitment and the percentage of cells that retained a neuronal fate within the lesioned area, compared to RV-GFP controls. RV-Pax6 expression was unsuccessful at inhibiting glial fate and intriguingly, increased OPC cell numbers with no change in neuronal recruitment. These findings suggest that gene choice is important when attempting to augment endogenous repair as the lesioned environment can overcome pro-neurogenic gene expression. Dlx2 over-expression however was able to partially overcome an anti-neuronal environment and therefore is a promising candidate for further study of striatal regeneration.

  14. Cell Sorting of Neural Stem and Progenitor Cells from the Adult Mouse Subventricular Zone and Live-imaging of their Cell Cycle Dynamics.

    Science.gov (United States)

    Daynac, Mathieu; Morizur, Lise; Kortulewski, Thierry; Gauthier, Laurent R; Ruat, Martial; Mouthon, Marc-André; Boussin, François D

    2015-01-01

    Neural stem cells (NSCs) in the subventricular zone of the lateral ventricles (SVZ) sustain olfactory neurogenesis throughout life in the mammalian brain. They successively generate transit amplifying cells (TACs) and neuroblasts that differentiate into neurons once they integrate the olfactory bulbs. Emerging fluorescent activated cell sorting (FACS) techniques have allowed the isolation of NSCs as well as their progeny and have started to shed light on gene regulatory networks in adult neurogenic niches. We report here a cell sorting technique that allows to follow and distinguish the cell cycle dynamics of the above-mentioned cell populations from the adult SVZ with a LeX/EGFR/CD24 triple staining. Isolated cells are then plated as adherent cells to explore in details their cell cycle progression by time-lapse video microscopy. To this end, we use transgenic Fluorescence Ubiquitination Cell Cycle Indicator (FUCCI) mice in which cells are red-fluorescent during G1 phase due to a G1 specific red-Cdt1 reporter. This method has recently revealed that proliferating NSCs progressively lengthen their G1 phase during aging, leading to neurogenesis impairment. This method is easily transposable to other systems and could be of great interest for the study of the cell cycle dynamics of brain cells in the context of brain pathologies. PMID:26436641

  15. Inhibition of the histone demethylase Kdm5b promotes neurogenesis and derepresses Reln (reelin) in neural stem cells from the adult subventricular zone of mice.

    Science.gov (United States)

    Zhou, Qiong; Obana, Edwin A; Radomski, Kryslaine L; Sukumar, Gauthaman; Wynder, Christopher; Dalgard, Clifton L; Doughty, Martin L

    2016-02-15

    The role of epigenetic regulators in the control of adult neurogenesis is largely undefined. We show that the histone demethylase enzyme Kdm5b (Jarid1b) negatively regulates neurogenesis from adult subventricular zone (SVZ) neural stem cells (NSCs) in culture. shRNA-mediated depletion of Kdm5b in proliferating adult NSCs decreased proliferation rates and reduced neurosphere formation in culture. When transferred to differentiation culture conditions, Kdm5b-depleted adult NSCs migrated from neurospheres with increased velocity. Whole-genome expression screening revealed widespread transcriptional changes with Kdm5b depletion, notably the up-regulation of reelin (Reln), the inhibition of steroid biosynthetic pathway component genes and the activation of genes with intracellular transport functions in cultured adult NSCs. Kdm5b depletion increased extracellular reelin concentration in the culture medium and increased phosphorylation of the downstream reelin signaling target Disabled-1 (Dab1). Sequestration of extracellular reelin with CR-50 reelin-blocking antibodies suppressed the increase in migratory velocity of Kdm5b-depleted adult NSCs. Chromatin immunoprecipitation revealed that Kdm5b is present at the proximal promoter of Reln, and H3K4me3 methylation was increased at this locus with Kdm5b depletion in differentiating adult NSCs. Combined the data suggest Kdm5b negatively regulates neurogenesis and represses Reln in neural stem cells from the adult SVZ. PMID:26739753

  16. A comparison of long-term survivors and short-term survivors with glioblastoma, subventricular zone involvement: a predictive factor for survival?

    International Nuclear Information System (INIS)

    Long-term survival is rare in patients with glioblastoma (GBM). We set out to determine prognostic factors for patients with favorable and poor prognosis in regard of tumor localization to the subventricular zone (SZV). We reviewed the clinical records, pre-operative and post-operative MRI imaging of 50 LTS long-term survivors (LTS) (> 3 years) and 50 short-term survivors (STS) (< 1 year) with glioblastoma. These groups were matched for clinical characteristics being consistently associated with prolonged or shortened survival. All patients had undergone initial surgery or biopsy to confirm GBM diagnosis followed by radio- or chemoradiotherapy. LTS had a median progression-free survival PFS of 25, 4 months (2, 3–97, 8 months) and overall-survival (OS) of 55, 9 months (38, 2-98, 6 months) compared to STS who had a significantly lower PFS of 4, 2 months (1, 4–10, 2 months) and OS of 6, 6 months (2, 2–11, 6 months) (each p < 0,001). Survival analysis showed that age under 60 years (p < 0,001), total resection status (p < 0,001) and tumor localization without SVZ contact (p = 0,05) were significant factors for prolonged survival. Our findings underline that survival in GBM patients is heterogeneous and influenced by multiple factors. This study confirms that tumor location with regard to the SVZ is significantly associated with survival

  17. CD133 is not present on neurogenic astrocytes in the adult subventricular zone, but on embryonic neural stem cells, ependymal cells, and glioblastoma cells.

    Science.gov (United States)

    Pfenninger, Cosima V; Roschupkina, Teona; Hertwig, Falk; Kottwitz, Denise; Englund, Elisabet; Bengzon, Johan; Jacobsen, Sten Eirik; Nuber, Ulrike A

    2007-06-15

    Human brain tumor stem cells have been enriched using antibodies against the surface protein CD133. An antibody recognizing CD133 also served to isolate normal neural stem cells from fetal human brain, suggesting a possible lineage relationship between normal neural and brain tumor stem cells. Whether CD133-positive brain tumor stem cells can be derived from CD133-positive neural stem or progenitor cells still requires direct experimental evidence, and an important step toward such investigations is the identification and characterization of normal CD133-presenting cells in neurogenic regions of the embryonic and adult brain. Here, we present evidence that CD133 is a marker for embryonic neural stem cells, an intermediate radial glial/ependymal cell type in the early postnatal stage, and for ependymal cells in the adult brain, but not for neurogenic astrocytes in the adult subventricular zone. Our findings suggest two principal possibilities for the origin of brain tumor stem cells: a derivation from CD133-expressing cells, which are normally not present in the adult brain (embryonic neural stem cells and an early postnatal intermediate radial glial/ependymal cell type), or from CD133-positive ependymal cells in the adult brain, which are, however, generally regarded as postmitotic. Alternatively, brain tumor stem cells could be derived from proliferative but CD133-negative neurogenic astrocytes in the adult brain. In the latter case, brain tumor development would involve the production of CD133. PMID:17575139

  18. Novel in vivo imaging techniques for trafficking the behavior of subventricular zone neural stem cells (SVZSC) and SVZSC induced functional repair

    Energy Technology Data Exchange (ETDEWEB)

    Anna-Liisa Brownell

    2003-11-28

    Adult progenitor cells hold promise for therapeutic treatment where there has been a disabling loss of function due to death of cells from trauma, disease or aging. However, it will be essential in clinical application to be able to follow the fate of the transplanted cells over time using in vivo tracking methods. We have developed protocol for labeling of progenitor cells to monitor cell trafficking by high resolution magnetic resonance imaging (MRI) and super high resolution positron emission tomography (PET). We have transfected rat subventricular zone stem cells (SVZ, progenitor cell line) and another control cell line (PC12, pheochromocytoma cells) utilizing super paramagnetic iron oxide and poly-L-lysine complex for MR imaging or radiolabeling with 18F-fluor deoxy-D- glucose for PET imaging. The labeled cells were transplanted into the rostral migratory stream (RMS) or striatum of normal or 6-hydroxydopamine lesioned Spraque-Dawley rats. Longitudinal MRI studies (up to 40 days) showed that transplantation site has significant impact to the fate of the cells; when SVZ cells were transplanted into the RMS, cells migrated several centimeter into the olfactory bulb; after transplantation into the striatum, the migration was minimal, only 2 mm. PC 12 cells grew a massive tumor after the striatal implantation and significantly smaller tumor after the RMS implantation. PET studies conducted immediately after transplantation verified the transplantation site. MRI studies were able to show the whole path of migration in one image, since part of the cells die during migration and will get detected because of iron content. Endpoint histological studies verified the cell survival and immunohistochemical studies revealed the differentiation of the transplanted cells into astrocytes and neurons.

  19. Distinct effects of pramipexole on the proliferation of adult mouse sub-ventricular zone-derived cells and the appearance of a neuronal phenotype.

    Science.gov (United States)

    Merlo, Sara; Canonico, Pier Luigi; Sortino, Maria Angela

    2011-05-01

    Pramipexole (PPX) is a dopamine agonist with an 8-fold higher affinity for D3 than D2 receptor, whose efficacy in the treatment of Parkinson's disease is based on dopamine agonistic activity. PPX has also been recently shown to be endowed with neuroprotective activity and neurogenic potential. The aim of this study was a more detailed characterization of PPX-induced neurogenesis. Both D2 and D3 receptors are expressed in floating and differentiated neurospheres obtained from the sub-ventricular zone (SVZ) of adult mice. Treatment of secondary neurospheres with 10 μM PPX causes a marked induction of cell proliferation, assessed by enhanced cell number and S phase population at cell cycle analysis. Stimulation of proliferation by PPX is still detectable in plated neurospheres before the onset of migration and differentiation, as by enhanced BrdU incorporation. This effect is sensitive to the selective D3 dopamine receptor antagonist U99194A, as well as to sulpiride. A 24 h treatment with PPX does not modify the morphology of neurosphere-derived cells, but causes an increase of glial fibrillary acidic protein (GFAP)-positive cells, an effect sensitive to both D2 and D3 antagonism. Differentiation toward the neuronal lineage is increased by PPX as shown by enhancement of the cell population positive to the early neuronal marker doublecortin (DCX) at 24 h and the mature neuronal marker microtubule associated protein (MAP2) at 72 h. This effect is not modified by treatment with U99194A and is mimicked by BDNF. Accordingly, PPX increases BDNF release with a mechanism involving D2 but not D3 receptors. PMID:21272591

  20. MicroRNA profiling in subventricular zone after stroke: MiR-124a regulates proliferation of neural progenitor cells through Notch signaling pathway.

    Directory of Open Access Journals (Sweden)

    Xian Shuang Liu

    Full Text Available BACKGROUND: The Notch signaling pathway regulates adult neurogenesis under physiological and pathophysiological conditions. MicroRNAs are small non-coding RNA molecules that regulate gene expression. The present study investigated the effect of miR-124a on the Notch signaling pathway in stroke-induced neurogenesis. METHODOLOGY AND PRINCIPAL FINDINGS: We found that adult rats subjected to focal cerebral ischemia exhibited substantial reduction of miR-124a expression, a neuron specific miRNA, in the neural progenitor cells of the subventricular zone (SVZ of the lateral ventricle, which was inversely associated with activation of Notch signals. In vitro, transfection of neural progenitor cells harvested from the SVZ of adult rat with miR-124a repressed Jagged-1 (JAG1, a ligand of Notch, in a luciferase construct containing the JAG1 target site. Introduction of miR-124a in neural progenitor cells significantly reduced JAG1 transcript and protein levels, leading to inactivation of Notch signals. Transfection of neural progenitor cells with miR-124a significantly reduced progenitor cell proliferation and promoted neuronal differentiation measured by an increase in the number of Doublecortin positive cells, a marker of neuroblasts. Furthermore, introduction of miR-124a significantly increased p27Kip1 mRNA and protein levels, a downstream target gene of the Notch signaling pathway. CONCLUSIONS: Collectively, our study demonstrated that in vivo, stroke alters miRNA expression in SVZ neural progenitor cells and that in vitro, miR-124a mediates stroke-induced neurogenesis by targeting the JAG-Notch signaling pathway.

  1. Increased doublecortin (DCX expression and incidence of DCX-immunoreactive multipolar cells in the subventricular zone-olfactory bulb system of suicides

    Directory of Open Access Journals (Sweden)

    Marissa E Maheu

    2015-06-01

    Full Text Available Postmortem studies have confirmed the occurrence of adult hippocampal neurogenesis in humans and implicated this process in antidepressant response, yet neurogenesis in other regions remains to be examined in the context of depression. Here we assess the extent of subventricular zone-olfactory bulb (SVZ-OB neurogenesis in adult humans having died by suicide. Protein expression of proliferative and neurogenic markers Sox2, proliferating cell nuclear antigen, and doublecortin (DCX were examined in postmortem SVZ and OB samples from depressed suicides and matched sudden-death controls. In the SVZ, DCX-immunoreactive (IR cells displayed phenotypes typical of progenitors, whereas in the olfactory tract (OT, they were multipolar with variable size and morphologies suggestive of differentiating cells. DCX expression was significantly increased in the OB of suicides, whereas SVZ DCX expression was higher among unmedicated, but not antidepressant-treated, suicides. Although very few DCX-IR cells were present in the control OT, they were considerably more common in suicides and correlated with OB DCX levels. Suicides also displayed higher DCX-IR process volumes. These results support the notion that OB neurogenesis is minimal in adult humans. They further indicate that the differentiation and migration of SVZ-derived neuroblasts may be altered in unmedicated suicides, leading to an accumulation of ectopically-differentiating cells in the OT. Normal SVZ DCX expression among suicides receiving antidepressants suggests a potentially novel mode of action of antidepressant medication. Given the modest group sizes and rarity of DCX-IR cells assessed here, a larger-scale characterization will be required before firm conclusions can be made regarding the identity of these cells.

  2. Hard-diet feeding recovers neurogenesis in the subventricular zone and olfactory functions of mice impaired by soft-diet feeding.

    Directory of Open Access Journals (Sweden)

    Chizuru Utsugi

    Full Text Available The subventricular zone (SVZ generates an immense number of neurons even during adulthood. These neurons migrate to the olfactory bulb (OB and differentiate into granule cells and periglomerular cells. The information broadcast by general odorants is received by the olfactory sensory neurons and transmitted to the OB. Recent studies have shown that a reduction of mastication impairs both neurogenesis in the hippocampus and brain functions. To examine these effects, we first measured the difference in Fos-immunoreactivity (Fos-ir at the principal sensory trigeminal nucleus (Pr5, which receives intraoral touch information via the trigeminal nerve, when female adult mice ingested a hard or soft diet to explore whether soft-diet feeding could mimic impaired mastication. Ingestion of a hard diet induced greater expression of Fos-ir cells at the Pr5 than did a soft diet or no diet. Bromodeoxyuridine-immunoreactive (BrdU-ir structures in sagittal sections of the SVZ and in the OB of mice fed a soft or hard diet were studied to explore the effects of changes in mastication on newly generated neurons. After 1 month, the density of BrdU-ir cells in the SVZ and OB was lower in the soft-diet-fed mice than in the hard-diet-fed mice. The odor preferences of individual female mice to butyric acid were tested in a Y-maze apparatus. Avoidance of butyric acid was reduced by the soft-diet feeding. We then explored the effects of the hard-diet feeding on olfactory functions and neurogenesis in the SVZ of mice impaired by soft-diet feeding. At 3 months of hard-diet feeding, avoidance of butyric acid was reversed and responses to odors and neurogenesis were recovered in the SVZ. The present results suggest that feeding with a hard diet improves neurogenesis in the SVZ, which in turn enhances olfactory function at the OB.

  3. Intranasal delivery of transforming growth factor-beta1 in mice after stroke reduces infarct volume and increases neurogenesis in the subventricular zone

    Directory of Open Access Journals (Sweden)

    Xu Gelin

    2008-12-01

    Full Text Available Abstract Background The effect of neurotrophic factors in enhancing stroke-induced neurogenesis in the adult subventricular zone (SVZ is limited by their poor blood-brain barrier (BBB permeability. Intranasal administration is a noninvasive and valid method for delivery of neuropeptides into the brain, to bypass the BBB. We investigated the effect of treatment with intranasal transforming growth factor-β1 (TGF-β1 on neurogenesis in the adult mouse SVZ following focal ischemia. The modified Neurological Severity Scores (NSS test was used to evaluate neurological function, and infarct volumes were determined from hematoxylin-stained sections. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL labeling was performed at 7 days after middle cerebral artery occlusion (MCAO. Immunohistochemistry was used to detect bromodeoxyuridine (BrdU and neuron- or glia-specific markers for identifying neurogenesis in the SVZ at 7, 14, 21, 28 days after MCAO. Results Intranasal treatment of TGF-β1 shows significant improvement in neurological function and reduction of infarct volume compared with control animals. TGF-β1 treated mice had significantly less TUNEL-positive cells in the ipsilateral striatum than that in control groups. The number of BrdU-incorporated cells in the SVZ and striatum was significantly increased in the TGF-β1 treated group compared with control animals at each time point. In addition, numbers of BrdU- labeled cells coexpressed with the migrating neuroblast marker doublecortin (DCX and the mature neuronal marker neuronal nuclei (NeuN were significantly increased after intranasal delivery of TGF-β1, while only a few BrdU labeled cells co-stained with glial fibrillary acidic protein (GFAP. Conclusion Intranasal administration of TGF-β1 reduces infarct volume, improves functional recovery and enhances neurogenesis in mice after stroke. Intranasal TGF-β1 may have therapeutic potential for cerebrovascular

  4. Novel in vivo imaging techniques for trafficking the behavior of subventricular zone neural stem cells (SVZSC) and SVZSC induced functional repair

    International Nuclear Information System (INIS)

    Adult progenitor cells hold promise for therapeutic treatment where there has been a disabling loss of function due to death of cells from trauma, disease or aging. However, it will be essential in clinical application to be able to follow the fate of the transplanted cells over time using in vivo tracking methods. We have developed protocol for labeling of progenitor cells to monitor cell trafficking by high resolution magnetic resonance imaging (MRI) and super high resolution positron emission tomography (PET). We have transfected rat subventricular zone stem cells (SVZ, progenitor cell line) and another control cell line (PC12, pheochromocytoma cells) utilizing super paramagnetic iron oxide and poly-L-lysine complex for MR imaging or radiolabeling with 18F-fluor deoxy-D- glucose for PET imaging. The labeled cells were transplanted into the rostral migratory stream (RMS) or striatum of normal or 6-hydroxydopamine lesioned Spraque-Dawley rats. Longitudinal MRI studies (up to 40 days) showed that transplantation site has significant impact to the fate of the cells; when SVZ cells were transplanted into the RMS, cells migrated several centimeter into the olfactory bulb; after transplantation into the striatum, the migration was minimal, only 2 mm. PC 12 cells grew a massive tumor after the striatal implantation and significantly smaller tumor after the RMS implantation. PET studies conducted immediately after transplantation verified the transplantation site. MRI studies were able to show the whole path of migration in one image, since part of the cells die during migration and will get detected because of iron content. Endpoint histological studies verified the cell survival and immunohistochemical studies revealed the differentiation of the transplanted cells into astrocytes and neurons

  5. Conical expansion of the outer subventricular zone and the role of neocortical folding in evolution and development

    Directory of Open Access Journals (Sweden)

    Eric eLewitus

    2013-08-01

    Full Text Available There is a basic rule to mammalian neocortical expansion: as it expands, so does it fold. The degree to which it folds, however, cannot strictly be attributed to its expansion. Across species, cortical volume does not keep pace with cortical surface area, but rather folds appear more rapidly than expected. As a result, larger brains quickly become disproportionately more convoluted than smaller brains. Both the absence (lissencephaly and presence (gyrencephaly of cortical folds is observed in all mammalian orders and, while there is likely some phylogenetic signature to the evolutionary appearance of gyri and sulci, there are undoubtedly universal trends to the acquisition of folds in an expanding neocortex. Whether these trends are governed by conical expansion of neocortical germinal zones, the distribution of cortical connectivity, or a combination of growth- and connectivity-driven forces remains an open question. But the importance of cortical folding for evolution of the uniquely mammalian neocortex, as well as for the incidence of neuropathologies in humans, is undisputed. In this hypothesis and theory article, we will summarize the development of cortical folds in the neocortex, consider the relative influence of growth- versus connectivity-driven forces for the acquisition of cortical folds between and within species, assess the genetic, cell-biological, and mechanistic implications for neocortical expansion, and discuss the significance of these implications for human evolution, development, and disease. We will argue that evolutionary increases in the density of neuron production, achieved via maintenance of a basal proliferative niche in the neocortical germinal zones, drive the conical migration of neurons towards the cortical surface and ultimately lead to the establishment of cortical folds in large-brained mammal species.

  6. Age-Dependent Increase of Brain Copper Levels and Expressions of Copper Regulatory Proteins in the Subventricular Zone and Choroid Plexus

    Directory of Open Access Journals (Sweden)

    Sherleen eFu

    2015-06-01

    Full Text Available Our recent data suggest a high accumulation of Cu in the subventricular zone (SVZ along the wall of brain ventricles. Anatomically, SVZ is in direct contact with cerebrospinal fluid (CSF, which is secreted by a neighboring tissue choroid plexus. Changes in Cu regulatory gene expressions in the SVZ and choroid plexus as the function of aging may determine Cu levels in the CSF and SVZ. This study was designed to investigate associations between age, Cu levels, and Cu regulatory genes in SVZ and plexus. The SVZ and choroid plexus were dissected from brains of 3-week, 10-week or 9-month old male rats. Analyses by atomic absorption spectroscopy revealed that the SVZ of adult and old animals contained the highest Cu level compared with other tested brain regions. Significant positive correlations between age and Cu levels in SVZ and plexus were observed; the SVZ Cu level of old animals was 7.5- and 5.8-fold higher than those of young and adult rats (p<0.01, respectively. Quantitation by qPCR of the transcriptional expressions of Cu regulatory proteins showed that the SVZ expressed the highest level of Cu storage protein MTs, while the choroid plexus expressed the high level of Cu transporter protein Ctr1. Noticeably, Cu levels in the SVZ were positively associated with type B slow proliferating cell marker Gfap (p<0.05, but inversely associated with type A proliferating neuroblast marker Dcx (p<0.05 and type C transit amplifying progenitor marker Nestin (p<0.01. Dmt1 had significant positive correlations with age and Cu levels in the plexus (p<0.01. These findings suggest that Cu levels in all tested brain regions are increased as the function of age. The SVZ shows a different expression pattern of Cu-regulatory genes from the choroid plexus. The age-related increase of MTs and decrease of Ctr1 may contribute to the high Cu level in this neurogenesis active brain region.

  7. Analysis of space-borne data for coastal zone information extraction of Goa Coast, India

    Digital Repository Service at National Institute of Oceanography (India)

    Kunte, P.D.; Wagle, B.G.

    Space-borne data covering the coastal zone of Goa State were processed using digital and visual image-processing techniques to extract information about the coastal zone. Digital image processing of thematic data included principal component...

  8. The carbocyanine dye DiD labels in vitro and in vivo neural stem cells of the subventricular zone as well as myelinated structures following in vivo injection in the lateral ventricle.

    Science.gov (United States)

    Carradori, Dario; Barreau, Kristell; Eyer, Joël

    2016-02-01

    Carbocyanines are fluorescent lipophilic cationic dyes used since the early 1980s as neuronal tracers. Several applications of these compounds have been developed thanks to their low cell toxicity, lateral diffusion within the cellular membranes, and good photostability. 1,1'-Dioctadecyl-3,3,3',3'-tetramethylindodicarbocyanine 4-chlorobenzenesulfonate (DiD) is an interesting component of this family because, in addition to the classic carbocyanine properties, it has a longer wavelength compared with its analogues. That makes DiD an excellent carbocyanine for labeling cells and tissues with significant intrinsic fluorescence. Drug encapsulation, drug delivery, and cellular transplantation are also fields using DiD-based systems where having detailed knowledge about its behavior as a single entity is important. Recently, promising studies concerned neural stem cells from the subventricular zone of the lateral ventricle in the brain (their natural niche) and their potential therapeutic use. Here, we show that DiD is able to label these stem cells in vitro and present basilar information concerning its pharmacokinetics, concentrations, and microscope protocols. Moreover, when DiD is injected in vivo in the cerebrospinal fluid present in the lateral ventricle of rat, it also labels stem cells as well as myelinated structures of the caudoputamen. This analysis provides a database to consult when planning experiments concerning DiD and neural stem cells from the subventricular zone. PMID:26566852

  9. Studying the Integration of Adult-born Neurons

    OpenAIRE

    Gu, Yan; Janoschka, Stephen; Ge, Shaoyu

    2011-01-01

    Neurogenesis occurs in adult mammalian brains in the sub-ventricular zone (SVZ) of the lateral ventricle and in the sub-granular zone (SGZ) of the hippocampal dentate gyrus throughout life. Previous reports have shown that adult hippocampal neurogenesis is associated with diverse brain disorders, including epilepsy, schizophrenia, depression and anxiety (1). Deciphering the process of normal and aberrant adult-born neuron integration may shed light on the etiology of these diseases and inform...

  10. Proliferation and Glia-Directed Differentiation of Neural Stem Cells in the Subventricular Zone of the Lateral Ventricle and the Migratory Pathway to the Lesions after Cortical Devascularization of Adult Rats

    Science.gov (United States)

    Wan, Feng; Bai, Hua-Jing; Liu, Jun-Qi; Tian, Mo; Wang, Yong-Xue; Niu, Xin; Si, Yin-Chu

    2016-01-01

    We investigated the effects of cortical devascularization on the proliferation, differentiation, and migration of neural stem cells (NSCs) in the subventricular zone (SVZ) of the lateral ventricle of adult rats. 60 adult male Wistar rats were randomly divided into control group and devascularized group. At 15 and 30 days after cerebral cortices were devascularized, rats were euthanized and immunohistochemical analysis was performed. The number of PCNA-, Vimentin-, and GFAP-positive cells in the bilateral SVZ of the lateral wall and the superior wall of the lateral ventricles of 15- and 30-day devascularized groups increased significantly compared with the control group (P < 0.05 and P < 0.01). The area density of PCNA-, Vimentin-, and GFAP-positive cells in cortical lesions of 15- and 30-day devascularized groups increased significantly compared with the control group (P < 0.05 and P < 0.01). PCNA-, GFAP-, and Vimentin-positive cells in the SVZ migrated through the rostral migratory stream (RMS), and PCNA-, GFAP-, and Vimentin-positive cells from both the ipsilateral and contralateral dorsolateral SVZ (dl-SVZ) migrated into the corpus callosum (CC) and accumulated, forming a migratory pathway within the CC to the lesioned site. Our study suggested that cortical devascularization induced proliferation, glia-directed differentiation, and migration of NSCs from the SVZ through the RMS or directly to the corpus callosum and finally migrating radially to cortical lesions. This may play a significant role in neural repair. PMID:27294116

  11. Phenytoin enhances the phosphorylation of epidermal growth factor receptor and fibroblast growth factor receptor in the subventricular zone and promotes the proliferation of neural precursor cells and oligodendrocyte differentiation.

    Science.gov (United States)

    Galvez-Contreras, Alma Y; Gonzalez-Castaneda, Rocio E; Campos-Ordonez, Tania; Luquin, Sonia; Gonzalez-Perez, Oscar

    2016-01-01

    Phenytoin is a widely used antiepileptic drug that induces cell proliferation in several tissues, such as heart, bone, skin, oral mucosa and neural precursors. Some of these effects are mediated via fibroblast growth factor receptor (FGFR) and epidermal growth factor receptor (EGFR). These receptors are strongly expressed in the adult ventricular-subventricular zone (V-SVZ), the main neurogenic niche in the adult brain. The aim of this study was to determine the cell lineage and cell fate of V-SVZ neural progenitors expanded by phenytoin, as well as the effects of this drug on EGFR/FGFR phosphorylation. Male BALB/C mice received 10 mg/kg phenytoin by oral cannula for 30 days. We analysed the proliferation of V-SVZ neural progenitors by immunohistochemistry and western blot. Our findings indicate that phenytoin enhanced twofold the phosphorylation of EGFR and FGFR in the V-SVZ, increased the number of bromodeoxyuridine (BrdU)+/Sox2+ and BrdU+/doublecortin+ cells in the V-SVZ, and expanded the population of Olig2-expressing cells around the lateral ventricles. After phenytoin removal, a large number of BrdU+/Receptor interacting protein (RIP)+ cells were observed in the olfactory bulb. In conclusion, phenytoin enhanced the phosphorylation of FGFR and EGFR, and promoted the expression of neural precursor markers in the V-SVZ. In parallel, the number of oligodendrocytes increased significantly after phenytoin removal. PMID:26370587

  12. The functional significance of newly born neurons integrated into olfactory bulb circuits

    OpenAIRE

    Sakamoto, Masayuki; Kageyama, Ryoichiro; Imayoshi, Itaru

    2014-01-01

    The olfactory bulb (OB) is the first central processing center for olfactory information connecting with higher areas in the brain, and this neuronal circuitry mediates a variety of odor-evoked behavioral responses. In the adult mammalian brain, continuous neurogenesis occurs in two restricted regions, the subventricular zone (SVZ) of the lateral ventricle and the hippocampal dentate gyrus. New neurons born in the SVZ migrate through the rostral migratory stream and are integrated into the ne...

  13. Mosaic Subventricular Origins of Forebrain Oligodendrogenesis.

    Science.gov (United States)

    Azim, Kasum; Berninger, Benedikt; Raineteau, Olivier

    2016-01-01

    In the perinatal as well as the adult CNS, the subventricular zone (SVZ) of the forebrain is the largest and most active source of neural stem cells (NSCs) that generates neurons and oligodendrocytes (OLs), the myelin forming cells of the CNS. Recent advances in the field are beginning to shed light regarding SVZ heterogeneity, with the existence of spatially segregated microdomains that are intrinsically biased to generate phenotypically distinct neuronal populations. Although most research has focused on this regionalization in the context of neurogenesis, newer findings underline that this also applies for the genesis of OLs under the control of specific patterning molecules. In this mini review, we discuss the origins as well as the mechanisms that induce and maintain SVZ regionalization. These come in the flavor of specific signaling ligands and subsequent initiation of transcriptional networks that provide a basis for subdividing the SVZ into distinct lineage-specific microdomains. We further emphasize canonical Wnts and FGF2 as essential signaling pathways for the regional genesis of OL progenitors from NSCs of the dorsal SVZ. This aspect of NSC biology, which has so far received little attention, may unveil new avenues for appropriately recruiting NSCs in demyelinating diseases. PMID:27047329

  14. Mosaic subventricular origins of forebrain oligodendroglia

    Directory of Open Access Journals (Sweden)

    Kasum eAzim

    2016-03-01

    Full Text Available In the perinatal as well as the adult CNS, the subventricular zone (SVZ of the forebrain is the largest and most active source of neural stem cells (NSCs that generates neurons and oligodendrocytes (OLs, the myelin forming cells of the CNS. Recent advances in the field are beginning to shed light regarding SVZ heterogeneity, with the existence of spatially segregated microdomains that are intrinsically biased to generate phenotypically distinct neuronal populations. Although most research has focused on this regionalization in the context of neurogenesis, newer findings underline that this also applies for the genesis of OLs under the control of specific patterning molecules. In this mini review, we discuss the origins as well as the mechanisms that induce and maintain SVZ regionalization. These come in the flavor of specific signaling ligands and subsequent initiation of transcriptional networks that provide a basis for subdividing the SVZ into distinct lineage-specific microdomains. We further emphasize canonical Wnt and FGF2 as essential signaling pathways for the regional genesis of OL progenitors from NSCs of the dorsal SVZ. This aspect of NSC biology, which has so far received little attention, may unveil new avenues for appropriately recruiting NSCs in demyelinating diseases.

  15. 缺氧缺血对人类胚胎脑室管膜下区神经细胞亚群的影响%Effects of hypoxia-ischemia on different neural cells in subventricular zone of human fetus

    Institute of Scientific and Technical Information of China (English)

    张燕舞; 陈燕惠

    2008-01-01

    higher survival rate than neurons and oligodendrocyte progenitors.%目的 研究缺氧缺血对妊娠中期人类胚胎脑室管膜下区(subventricular zone,SVZ)神经细胞亚群的影响.方法 取即刻解离的妊娠中期人类胚胎脑SVZ细胞,分缺氧缺血组(HI组)和对照组短时培养.以氧糖缺失法(OGD)制备缺氧缺血损伤细胞模型.培养前以细胞成活率评价损伤程度,培养后以细胞特异性标志蛋白nestin、MAP2、GFAP、PDGFRa及RCA120的抗体通过免疫荧光细胞化学法分别鉴定神经干细胞(NSCs)、神经元、星形胶质细胞、少突胶质祖细胞及小胶质细胞,比较其百分含量.结果 HI组的细胞成活率(63.41%±0.06%),明显低于正常组(98.9%±0.01%)(P<0.001),短时培养后HI组中细胞亚群中含量最高的是GFAP(+)的星形胶质细胞56.48%±0.03%,其次为神经干细胞NSCs 22.47%±0.03%而PDGFRa(+)的少突胶质祖细胞含量最低;在对照组中最高则为MAP2(+)的神经元48.81%±0.03%,其次为GFAP(+)的星形胶质细胞32.31%±0.03%.含量最少的为小胶质细胞1.15%±0.01%.结论 妊娠中期人类胚胎脑SVZ含有NSCs、神经元、星形胶质细胞、少突胶质祖细胞和小胶质细胞,缺氧缺血对SVZ神经细胞损伤明显,不同细胞对缺氧缺血损伤的耐受性不同:NSCs、星形胶质细胞对缺氧缺血损伤的耐受性相对强于神经元、少突胶质祖细胞.

  16. Diffraction of multilayer gratings and zone plates in the x-ray region using the Born approximation

    International Nuclear Information System (INIS)

    New devices combining the Bragg reflection from periodic multilayer structures with Fraunhofer or Fresnel diffraction arising from lateral patterning of the multilayer are now available for x-ray optics. Using Green's-function method, the authors establish an integral equation for the scattered amplitude that is valid in the framework of both Fraunhofer and Fresnel diffraction. The scattered amplitude is given in the first and the second Born approximations for multilayer mirrors, laminar and sawtooth-profile multilayer gratings, and linear multilayer zone plates. The main diffractive properties of these devices are deduced. The efficiencies are computed in the first and/or in the second Born approximation and are compared with efficiencies obtained from a rigorous electromagnetic theory when they are available. 18 refs., 10 figs., 1 tab

  17. Iatrogenic Blood-borne Viral Infections in Refugee Children from War and Transition Zones

    OpenAIRE

    Goldwater, Paul N.

    2013-01-01

    Pediatric infectious disease clinicians in industrialized countries may encounter iatrogenically transmitted HIV, hepatitis B virus, and hepatitis C virus infections in refugee children from Central Asia, Southeast Asia, and sub-Saharan Africa. The consequences of political collapse and/or civil war—work migration, prostitution, intravenous drug use, defective public health resources, and poor access to good medical care—all contribute to the spread of blood-borne viruses. Inadequate infectio...

  18. Satisfaction with emergency obstetric and new born care services among clients using public health facilities in Jimma Zone, Oromia Regional State, Ethiopia; a cross sectional study

    OpenAIRE

    Kumsa, Alemayehu; Tura, Gurmessa; Nigusse, Aderajew; Kebede, Getahun

    2016-01-01

    Background The 2005 report of United Nations Millennium Project of Transforming Health Systems for women and children concluded that universal access to Emergency Obstetric and New born Care could reduce maternal deaths by 74 %. Even though some studies investigated quality of Emergency Obstetric and New born Care in different parts of the world, there is scarcity of data regarding this issue in Ethiopia, particularly in Jimma zone. Therefore, the aim of this study was to assess satisfaction ...

  19. The prevalence of serum antibodies to tick-borne infections in Mbale District, Uganda: The effect of agro-ecological zone, grazing management and age of cattle

    Directory of Open Access Journals (Sweden)

    C. Rubaire-Akiiki

    2004-03-01

    Full Text Available Between August and October 2000, a cross-sectional study was conducted in smallholder dairy farms in Mbale District, Uganda to assess the prevalence of ticks and tick-borne diseases under different grazing systems and agro-ecological zones and understand the circumstances under which farmers operated. A questionnaire was administered to obtain information on dairy farm circumstances and practices. A total of 102 farms were visited and sera and ticks were collected from 478 animals. Sero-prevalence of tick-borne diseases was determined using an enzyme-linked immunoassay. Acaricides were used indiscriminately but the intensity of their use varied with the grazing system and zone. Cattle from different farms mixed for various reasons. During the dry seasons farmers have to get additional fodder from outside their farms that can result in importation of ticks. The prevalence of ticks and serum antibodies to tick-borne infections differed across the grazing systems and zones. The highest serum antibody prevalence (>60% was recorded in the lowland zone under the free range and tethering grazing systems. The lowest tick challenge and serum antibody levels (<50% were recorded in the midland and upland zones under a zero-grazing system. These findings suggest that endemic stability to East Coast Fever, babesiosis and anaplasmosis is most likely to have existed in the lowland zone, particularly, under the tethering and free-range grazing systems. Also, endemic stability for babesiosis existed in the upland zones. Endemic instability for East Coast Fever existed in the midland and upland zones. These structured observational studies are instrumental in planning of control strategies for ticks and tick borne diseases since production systems and the cattle population at high risk of the diseases in the district have been identified.

  20. The prevalence of serum antibodies to tick-borne infections in Mbale District, Uganda: the effect of agro-ecological zone, grazing management and age of cattle.

    Science.gov (United States)

    Rubaire-Akiiki, C; Okello-Onen, J; Nasinyama, G W; Vaarst, M; Kabagambe, E K; Mwayi, W; Musunga, D; Wandukwa, W

    2004-01-01

    Between August and October 2000, a cross-sectional study was conducted in smallholder dairy farms in Mbale District, Uganda to assess the prevalence of ticks and tick-borne diseases under different grazing systems and agro-ecological zones and understand the circumstances under which farmers operated. A questionnaire was administered to obtain information on dairy farm circumstances and practices. A total of 102 farms were visited and sera and ticks were collected from 478 animals. Sero-prevalence of tick-borne diseases was determined using an enzyme-linked immunoassay. Acaricides were used indiscriminately but the intensity of their use varied with the grazing system and zone. Cattle from different farms mixed for various reasons. During the dry seasons farmers have to get additional fodder from outside their farms that can result in importation of ticks. The prevalence of ticks and serum antibodies to tick-borne infections differed across the grazing systems and zones. The highest serum antibody prevalence (>60%) was recorded in the lowland zone under the free range and tethering grazing systems. The lowest tick challenge and serum antibody levels (<50%) were recorded in the midland and upland zones under a zero-grazing system. These findings suggest that endemic stability to East Coast Fever, babesiosis and anaplasmosis is most likely to have existed in the lowland zone, particularly, under the tethering and free-range grazing systems. Also, endemic stability for babesiosis existed in the upland zones. Endemic instability for East Coast Fever existed in the midland and upland zones. These structured observational studies are instrumental in planning of control strategies for ticks and tick borne diseases since production systems and the cattle population at high risk of the diseases in the district have been identified. PMID:15861224

  1. Urban Market Gardening and Rodent-Borne Pathogenic Leptospira in Arid Zones: A Case Study in Niamey, Niger.

    Directory of Open Access Journals (Sweden)

    Gauthier Dobigny

    Full Text Available Leptospirosis essentially affects human following contact with rodent urine-contaminated water. As such, it was mainly found associated with rice culture, recreational activities and flooding. This is also the reason why it has mainly been investigated in temperate as well as warm and humid regions, while arid zones have been only very occasionally monitored for this disease. In particular, data for West African countries are extremely scarce. Here, we took advantage of an extensive survey of urban rodents in Niamey, Niger, in order to look for rodent-borne pathogenic Leptospira species presence and distribution across the city. To do so, we used high throughput bacterial 16S-based metabarcoding, lipL32 gene-targeting RT-PCR, rrs gene sequencing and VNTR typing as well as GIS-based multivariate spatial analysis. Our results show that leptospires seem absent from the core city where usual Leptospira reservoir rodent species (namely R. rattus and M. natalensis are yet abundant. On the contrary, L. kirschneri was detected in Arvicanthis niloticus and Cricetomys gambianus, two rodent species that are restricted to irrigated cultures within the city. Moreover, the VNTR profiles showed that rodent-borne leptospires in Niamey belong to previously undescribed serovars. Altogether, our study points towards the importance of market gardening in maintain and circulation of leptospirosis within Sahelian cities. In Africa, irrigated urban agriculture constitutes a pivotal source of food supply, especially in the context of the ongoing extensive urbanization of the continent. With this in mind, we speculate that leptospirosis may represent a zoonotic disease of concern also in arid regions that would deserve to be more rigorously surveyed, especially in urban agricultural settings.

  2. Urban Market Gardening and Rodent-Borne Pathogenic Leptospira in Arid Zones: A Case Study in Niamey, Niger.

    Science.gov (United States)

    Dobigny, Gauthier; Garba, Madougou; Tatard, Caroline; Loiseau, Anne; Galan, Max; Kadaouré, Ibrahima; Rossi, Jean-Pierre; Picardeau, Mathieu; Bertherat, Eric

    2015-01-01

    Leptospirosis essentially affects human following contact with rodent urine-contaminated water. As such, it was mainly found associated with rice culture, recreational activities and flooding. This is also the reason why it has mainly been investigated in temperate as well as warm and humid regions, while arid zones have been only very occasionally monitored for this disease. In particular, data for West African countries are extremely scarce. Here, we took advantage of an extensive survey of urban rodents in Niamey, Niger, in order to look for rodent-borne pathogenic Leptospira species presence and distribution across the city. To do so, we used high throughput bacterial 16S-based metabarcoding, lipL32 gene-targeting RT-PCR, rrs gene sequencing and VNTR typing as well as GIS-based multivariate spatial analysis. Our results show that leptospires seem absent from the core city where usual Leptospira reservoir rodent species (namely R. rattus and M. natalensis) are yet abundant. On the contrary, L. kirschneri was detected in Arvicanthis niloticus and Cricetomys gambianus, two rodent species that are restricted to irrigated cultures within the city. Moreover, the VNTR profiles showed that rodent-borne leptospires in Niamey belong to previously undescribed serovars. Altogether, our study points towards the importance of market gardening in maintain and circulation of leptospirosis within Sahelian cities. In Africa, irrigated urban agriculture constitutes a pivotal source of food supply, especially in the context of the ongoing extensive urbanization of the continent. With this in mind, we speculate that leptospirosis may represent a zoonotic disease of concern also in arid regions that would deserve to be more rigorously surveyed, especially in urban agricultural settings. PMID:26437456

  3. The prevalence of serum antibodies to tick-borne infections in Mbale District, Uganda: The effect of agro-ecological zone, grazing management and age of cattle

    OpenAIRE

    Rubaire-Akiiki, C.; J.Okello-Onen; G.W. Nasinyama; Vaarst, M; Kabagambe, E. K.; W. Mwayi; Musunga, D.; Wandukwa, W.

    2004-01-01

    Between August and October 2000, a cross-sectional study was conducted in smallholder dairy farms in Mbale District, Uganda to assess the prevalence of ticks and tick-borne diseases under different grazing systems and agro-ecological zones and understand the circumstances under which farmers operated. A questionnaire was administered to obtain information on dairy farm circumstances and practices. A total of 102 farms were visited and sera and ticks were collected from 478 animals. Sero-preva...

  4. Genetic Methods to Identify and Manipulate Newly born Neurons in the Adult Brain

    Directory of Open Access Journals (Sweden)

    Itaru eImayoshi

    2011-05-01

    Full Text Available Although mammalian neurogenesis is mostly completed by the perinatal period, new neurons are continuously generated in the subventricular zone of the lateral ventricle and the subgranular zone of the hippocampal dentate gyrus. Since the discovery of adult neurogenesis, many extensive studies have been performed on various aspects of adult neurogenesis, including proliferation and fate-specification of adult neural stem cells, and the migration, maturation and synaptic integration of newly born neurons. Furthermore, recent research has shed light on the intensive contribution of adult neurogenesis to olfactory-related and hippocampus-mediated brain functions. The field of adult neurogenesis progressed tremendously thanks to technical advances that facilitate the identification and selective manipulation of newly born neurons among billions of pre-existing neurons in the adult central nervous system. In this review, we introduce recent advances in the methodologies for visualizing newly generated neurons and manipulating neurogenesis in the adult brain. Particularly, the application of site-specific recombinases and Tet inducible system in combination with transgenic or gene targeting strategy is discussed in further detail.

  5. Urban market gardening and rodent-borne pathogenic leptospira in arid zones : a case study in Niamey, Niger

    OpenAIRE

    Gauthier Dobigny; Madougou Garba; Caroline Tatard; Anne Loiseau; Max Galan; Ibrahima Kadaouré; Jean-Pierre Rossi; Mathieu Picardeau; Eric Bertherat

    2015-01-01

    Leptospirosis essentially affects human following contact with rodent urine-contaminated water. As such, it was mainly found associated with rice culture, recreational activities and flooding. This is also the reason why it has mainly been investigated in temperate as well as warm and humid regions, while arid zones have been only very occasionally monitored for this disease. In particular, data for West African countries are extremely scarce. Here, we took advantage of an extensive survey of...

  6. U-Pb Zircon geochronology and Sr-Nd isotopic characteristic of Late Neo proterozoic Born award granitoids (Taknar zone exotic block), Iran

    International Nuclear Information System (INIS)

    The study area (Born award granite) is located in northeast of Iran (Khorasan Razavi province), about 280 km southwest of Mashhad city. Taknar zone is an exotic block, bordered by two major faults, Great Kavir fault (Drouneh) to the south and Rivash fault in the north. A complex of granite, granodiorite, monzonite and diorite crop out at the center of Taknar zone. They are named as Bornaward granite. Published data using Rb-Sr whole-rock and biotite isotopic methods on granitoid rocks (Born award granite) gave ages of 154 to 111 Ma. The results of U-Pb zircon dating of granodiorite is 552.69 ± 10.89 Ma and granite is 538.22 - 1.82, + 4.28 Ma (Late Neo proterozoic time). Both granite and granodiorite are classified as belonging to the ilmenite-series of reduced S-type granitoids. Chemically, they are per-aluminous, high-K calc-alkaline with relatively enriched in LILE, Rb, K and depleted in Sr, Ba, Nb, Ti, Ta, Y and Yb. Chondrite-normalized Rare Earth Element plots indicate minor enrichments of light Rare Earth Element in composition with heavy Rare Earth Element, with (La/Yb)N between 3.5-5.6 and high total Rare Earth Element (193-252) with strong negative anomaly of Eu. They have a initial 87Sr/86Sr and 143Nd/144Nd ranging from 0.713566 to 0.716888 and 0.511791 to 0.511842, respectively, when recalculated to an age of 553 and 538 Ma, consistent with the new radiometric results. Initial εNd isotope values for granite and granodiorite range from -2,62 to -2,01. Granite and granodiorite of Born award yields a TDM age of 1.4-1.41 Ga. This indicates that the granites and granodiorite being derived from partial melting of distinct basement source regions with very high initial 87Sr/86Sr.

  7. The functional significance of newly born neurons integrated into olfactory bulb circuits

    Directory of Open Access Journals (Sweden)

    Masayuki eSakamoto

    2014-05-01

    Full Text Available The olfactory bulb (OB is the first central processing center for olfactory information connecting with higher areas in the brain, and this neuronal circuitry mediates a variety of odor-evoked behavioral responses. In the adult mammalian brain, continuous neurogenesis occurs in two restricted regions, the subventricular zone (SVZ of the lateral ventricle and the hippocampal dentate gyrus. New neurons born in the SVZ migrate through the rostral migratory stream and are integrated into the neuronal circuits of the OB throughout life. The significance of this continuous supply of new neurons in the OB has been implicated in plasticity and memory regulation. Two decades of huge investigation in adult neurogenesis revealed the biological importance of integration of new neurons into the olfactory circuits. In this review, we highlight the recent findings about the physiological functions of newly generated neurons in rodent OB circuits and then discuss the contribution of neurogenesis in the brain function. Finally, we introduce cutting edge technologies to monitor and manipulate the activity of new neurons.

  8. Impaired cell proliferation in the subventricular zone in an Alzheimer's disease model.

    Czech Academy of Sciences Publication Activity Database

    Rodríguez Arellano, Jose Julio; Jones, V. C.; Verkhratsky, Alexei

    2009-01-01

    Roč. 20, č. 10 (2009), s. 907-912. ISSN 0959-4965 R&D Projects: GA ČR GA309/09/1696 Institutional research plan: CEZ:AV0Z50390512 Keywords : adult neurogenesis * Alzheimer's disease * cell proliferation Subject RIV: FH - Neurology Impact factor: 1.805, year: 2009

  9. RAE-1 is expressed in the adult subventricular zone and controls cell proliferation of neurospheres

    DEFF Research Database (Denmark)

    Popa, Natalia; Cédile, Oriane; Pollet-Villard, Xavier;

    2011-01-01

    Improving and controlling the capacity of endogenous or grafted adult neural stem cells to repair the nervous system relies on a better knowledge of interactions between immune cells and neural stem cells. Class I major histocompatibility complex (MHC) family members comprise numerous proteins pl...... reveal an unexpected role of RAE-1 in regulating adult SVZ neurogenesis by supporting stem/progenitor cells proliferation.......Improving and controlling the capacity of endogenous or grafted adult neural stem cells to repair the nervous system relies on a better knowledge of interactions between immune cells and neural stem cells. Class I major histocompatibility complex (MHC) family members comprise numerous proteins...... of two MHC class I-related members by neural stem/progenitor cells: retinoic acid early induced transcript (RAE)-1 and CD1d. The expression of RAE-1 but not CD1d disappears when differentiation of neurosphere cells is induced. Interestingly, RAE-1 transcripts are expressed in the brain during...

  10. Characterization of Seeding Conditions for Studies on Differentiation Patterns of Subventricular Zone Derived Neurospheres

    OpenAIRE

    Sanchez-Mendoza, Eduardo H.; Schlechter, Jana; Hermann, Dirk M.; Doeppner, Thorsten R.

    2016-01-01

    Stem cell research depends on extensive in vitro research. Poly-D-lysine (PDL) and polyornithine (PornT) are chemically synthesized amino acid chains promoting cell adhesion to solid substrates. Although, PDL and PornT are extensively used, there is no common agreement regarding the most optimal substance and its concentration. We therefore aimed at testing the effect of increasing concentrations (10, 50, and 100 μg/ml) for each compound and their corresponding mixtures (5+5 and 10+10 μg/ml) ...

  11. Characterization of seeding conditions for studies on differentiation patterns of subventricular zone derived neurospheres

    OpenAIRE

    Sanchez-Mendoza, Eduardo H.; Jana eSchlechter; Dirk Matthias Hermann; Thorsten Roland Doeppner

    2016-01-01

    Stem cell research depends on extensive in vitro research. Poly-D-Lysine (PDL) and Polyornithine (PornT) are chemically synthesized amino acid chains promoting cell adhesion to solid substrates. Although PDL and PornT are extensively used, there is no common agreement regarding the most optimal substance and its concentration. We therefore aimed at testing the effect of increasing concentrations (10, 50 and 100 µg/ml) for each compound and their corresponding mixtures (5+5 and 10+10 µg/ml) on...

  12. Novel primate miRNAs co-evolved with ancient target genes in germinal zone specific expression patterns

    OpenAIRE

    Arcila, ML; Betizeau, M; Cambronne, XA; Guzman, E; Doerflinger, N; Bouhallier, F; Zhou, H; Wu, B; N. Rani; Bassett, DS; Borello, U; Huissoud, C.; Goodman, RH; Dehay, C; Kosik, KS

    2014-01-01

    Major nonprimate-primate differences in corticogenesis include the dimensions, precursor lineages, and developmental timing of the germinal zones (GZs). microRNAs (miRNAs) of laser-dissected GZ compartments and cortical plate (CP) from embryonic E80 macaque visual cortex were deep sequenced. The CP and the GZ including ventricular zone (VZ) and outer and inner subcompartments of the outer subventricular zone (OSVZ) in area 17 displayed unique miRNA profiles. miRNAs present in primate, but abs...

  13. Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal

    OpenAIRE

    Fietz, Simone A.; Lachmann, Robert; Brandl, Holger; Kircher, Martin; Samusik, Nikolay; Schröder, Roland; Lakshmanaperumal, Naharajan; Henry, Ian; Vogt, Johannes; Riehn, Axel; Distler, Wolfgang; Nitsch, Robert; Enard, Wolfgang; Pääbo, Svante; Huttner, Wieland B.

    2012-01-01

    The expansion of the neocortex during mammalian brain evolution results primarily from an increase in neural progenitor cell divisions in its two principal germinal zones during development, the ventricular zone (VZ) and the subventricular zone (SVZ). Using mRNA sequencing, we analyzed the transcriptomes of fetal human and embryonic mouse VZ, SVZ, and cortical plate. In mouse, the transcriptome of the SVZ was more similar to that of the cortical plate than that of the VZ, whereas in human the...

  14. Tick-borne protozoa

    Science.gov (United States)

    Tick-borne protozoa impose a significant health burden on humans and animals throughout the world. The virulence of tick-borne protozoa, and the geographic distribution of their tick vectors and vertebrate hosts remain in flux as they adapt to changing environmental and climatic conditions. Babesios...

  15. Food-borne Zoonoses

    Science.gov (United States)

    Background: The awareness of food borne illness has shifted over the years as international agribusiness and transportation have steadily increased. At least 30 food borne agents have been identified, with one-third emerging in the last 3 decades. Despite an increased emphasis on control measures, t...

  16. The male sex pheromone darcin stimulates hippocampal neurogenesis and cell proliferation in the subventricular zone in female mice

    Directory of Open Access Journals (Sweden)

    Emma Hoffman

    2015-04-01

    Full Text Available The integration of newly generated neurons persists throughout life in the mammalian olfactory bulb and hippocampus, regions involved in olfactory and spatial learning. Social cues can be potent stimuli for increasing adult neurogenesis; for example, odors from dominant but not subordinate male mice increase neurogenesis in both brain regions of adult females. However, little is known about the role of neurogenesis in social recognition or the assessment of potential mates. Dominant male mice scent-mark territories using urine that contains a number of pheromones including darcin (MUP20, a male-specific major urinary protein that stimulates rapid learned attraction to the spatial location and individual odor signature of the scent owner. Here we investigate whether exposure to darcin stimulates neurogenesis in the female brain. Hippocampal neurons and cellular proliferation in the lateral ventricles that supply neurons to the olfactory bulbs increased in females exposed for seven days to male urine containing at least 0.5µg/µl darcin. Darcin was effective whether presented alone or in the context of male urine, but other information in male urine appeared to modulate the proliferative response. When exposed to urine from wild male mice, hippocampal proliferation increased only if urine was from the same individual over seven days, suggesting that consistency of individual scent signatures is important. While seven days exposure to male scent initiated the first stages of increased neurogenesis, this caused no immediate increase in female attraction to the scent or in the strength or robustness of spatial learning in short-term conditioned place preference tests. The reliable and consistent stimulation of neurogenesis by a pheromone important in rapid social learning suggests that this may provide an excellent model to explore the relationship between the integration of new neurons and plasticity in spatial and olfactory learning in a socially-relevant context.

  17. The male sex pheromone darcin stimulates hippocampal neurogenesis and cell proliferation in the subventricular zone in female mice.

    Science.gov (United States)

    Hoffman, Emma; Pickavance, Lucy; Thippeswamy, Thimmasettappa; Beynon, Robert J; Hurst, Jane L

    2015-01-01

    The integration of newly generated neurons persists throughout life in the mammalian olfactory bulb and hippocampus, regions involved in olfactory and spatial learning. Social cues can be potent stimuli for increasing adult neurogenesis; for example, odors from dominant but not subordinate male mice increase neurogenesis in both brain regions of adult females. However, little is known about the role of neurogenesis in social recognition or the assessment of potential mates. Dominant male mice scent-mark territories using urine that contains a number of pheromones including darcin (MUP20), a male-specific major urinary protein that stimulates rapid learned attraction to the spatial location and individual odor signature of the scent owner. Here we investigate whether exposure to darcin stimulates neurogenesis in the female brain. Hippocampal neurons and cellular proliferation in the lateral ventricles that supply neurons to the olfactory bulbs increased in females exposed for 7 days to male urine containing at least 0.5 μg/μl darcin. Darcin was effective whether presented alone or in the context of male urine, but other information in male urine appeared to modulate the proliferative response. When exposed to urine from wild male mice, hippocampal proliferation increased only if urine was from the same individual over 7 days, suggesting that consistency of individual scent signatures is important. While 7 days exposure to male scent initiated the first stages of increased neurogenesis, this caused no immediate increase in female attraction to the scent or in the strength or robustness of spatial learning in short-term conditioned place preference tests. The reliable and consistent stimulation of neurogenesis by a pheromone important in rapid social learning suggests that this may provide an excellent model to explore the relationship between the integration of new neurons and plasticity in spatial and olfactory learning in a socially-relevant context. PMID:25972792

  18. Depletion of neural stem cells from the subventricular zone of adult mouse brain using cytosine b‐Arabinofuranoside

    OpenAIRE

    Ghanbari, Amir; Esmaeilpour, Tahereh; Bahmanpour, Soghra; Golmohammadi, Mohammad Ghasem; Sharififar, Sharareh; Azari, Hassan

    2015-01-01

    Abstract Introduction Neural stem cells (NSCs) reside along the ventricular axis of the mammalian brain. They divide infrequently to maintain themselves and the down‐stream progenitors. Due to the quiescent property of NSCs, attempts to deplete these cells using antimitotic agents such as cytosine b‐Aarabinofuranoside (Ara‐C) have not been successful. We hypothesized that implementing infusion gaps in Ara‐C kill paradigms would recruit the quiescent NSCs and subsequently eliminate them from t...

  19. Tick-borne encephalitis

    Czech Academy of Sciences Publication Activity Database

    Růžek, Daniel; Bilski, B.; Günther, G.

    Florida : CRC Press, 2013, s. 211-237. ISBN 9781466567207 Institutional support: RVO:60077344 Keywords : tick-borne encephalitis * neuroviral Infections * viruses Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine

  20. Vector-borne Infections

    Centers for Disease Control (CDC) Podcasts

    2011-04-18

    This podcast discusses emerging vector-borne pathogens, their role as prominent contributors to emerging infectious diseases, how they're spread, and the ineffectiveness of mosquito control methods.  Created: 4/18/2011 by National Center for Emerging Zoonotic and Infectious Diseases (NCEZID).   Date Released: 4/27/2011.

  1. Vector-borne diseases.

    Science.gov (United States)

    Gubler, D J

    2009-08-01

    Vector-borne diseases have been the scourge of man and animals since the beginning of time. Historically, these are the diseases that caused the great plagues such as the 'Black Death' in Europe in the 14th Century and the epidemics of yellow fever that plagued the development of the New World. Others, such as Nagana, contributed to the lack of development in Africa for many years. At the turn of the 20th Century, vector-borne diseases were among the most serious public and animal health problems in the world. For the most part, these diseases were controlled by the middle of the 20th Century through the application of knowledge about their natural history along with the judicious use of DDT (dichlorodiphenyltrichloroethane) and other residual insecticides to interrupt the transmission cycle between arthropod and vertebrate host. However, this success initiated a period of complacency in the 1960s and 1970s, which resulted in the redirection of resources away from prevention and control of vector-borne diseases. The 1970s was also a time in which there were major changes to public health policy. Global trends, combined with changes in animal husbandry, urbanisation, modern transportation and globalisation, have resulted in a global re-emergence of epidemic vector-borne diseases affecting both humans and animals over the past 30 years. PMID:20128467

  2. Vector-borne Infections

    OpenAIRE

    Rosenberg, Ronald; Ben Beard, C.

    2011-01-01

    Infections with vector-borne pathogens are a major source of emerging diseases. The ability of vectors to bridge spatial and ecologic gaps between animals and humans increases opportunities for emergence. Small adaptations of a pathogen to a vector can have profound effects on the rate of transmission to humans.

  3. Tick-Borne Encephalitis (TBE)

    Science.gov (United States)

    ... Search The CDC Cancel Submit Search The CDC Tick-borne Encephalitis (TBE) Note: Javascript is disabled or ... CDC.gov . Recommend on Facebook Tweet Share Compartir Tick-borne encephalitis, or TBE, is a human viral ...

  4. The Born Rule Dies

    CERN Document Server

    Page, Don N

    2009-01-01

    The Born rule may be stated mathematically as the rule that probabilities in quantum theory are expectation values of a complete orthogonal set of projection operators. This rule works for single laboratory settings in which the observer can distinguish all the different possible outcomes corresponding to the projection operators. However, theories of inflation suggest that the universe may be so large that any laboratory, no matter how precisely it is defined by its internal state, may exist in a large number of very distantly separated copies throughout the vast universe. In this case, no observer within the universe can distinguish all possible outcomes for all copies of the laboratory. Then normalized probabilities for the local outcomes that can be locally distinguished cannot be given by the expectation values of any projection operators. Thus the Born rule dies and must be replaced by another rule for observational probabilities in cosmology. The freedom of what this new rule is to be is the measure pr...

  5. Where was Joseph Babinski born?

    Directory of Open Access Journals (Sweden)

    H A G Teive

    2011-01-01

    Full Text Available There is controversy in the neurological literature about where Joseph Babinski was born, including a myth propounded by various important authors that he was born in Lima, Peru. However, according to the most consistent biographical data, he was in fact born in Paris, France, and became a medical celebrity there and in Poland as well as around the world.

  6. Born-Infeld Cosmologies

    CERN Document Server

    García-Salcedo, R; Garcia-Salcedo, Ricardo; Breton, Nora

    2000-01-01

    We present a model for an inhomogeneous and anisotropic early universe filled with a nonlinear electromagnetic field of Born-Infeld (BI) type. The effects of the BI field are compared with the linear case (Maxwell). Since the curvature invaria nts are well behaved then we conjecture that our model does not present an initial big bang singularity. The existence of the BI field modifies the curvature invariants at t=0 as well as sets bounds on the amplitude of the conformal metric function

  7. Outdoor Workers and Tick-Borne Diseases

    Science.gov (United States)

    ... and Scorpions Poisonous Plants Venomous Spiders Venomous Snakes Vector-Borne Diseases Mosquito-Borne Diseases Tick-Borne Diseases Lyme Disease ... and Scorpions Poisonous Plants Venomous Spiders Venomous Snakes Vector-Borne Diseases Mosquito-Borne Diseases Tick-Borne Diseases Lyme Disease ...

  8. Born In Bradford Mobile Application

    OpenAIRE

    Lee, Stella; Walda, Martin; Vasiliki, Delimpasi

    2015-01-01

    The Born In Bradford mobile application is an Android mobile application and a working prototype that enables interaction with a sample cohort of the Born in Bradford study. It provides an interface and visualization for several surveys participated in by mothers and their children. This data is stored in the Born In Bradford database. A subset of this data is provided for mothers and children. The mobile application provides a way to engage the mothers and promote their consistency in partic...

  9. Early Recollections of First-Borns.

    Science.gov (United States)

    Fakouri, M. Ebrahim; Hafner, James L.

    1984-01-01

    Compared the early recollections of 50 first-borns and 98 later-borns. The first-borns mentioned significantly more nonfamily members, illness/injury, hospital/doctor's office. Later-borns mentioned significantly more siblings than did first-borns. Findings were discussed in the context of Adler's personality theory. (JAC)

  10. Born-Infeld cosmology with scalar Born-Infeld matter

    CERN Document Server

    Jana, Soumya

    2016-01-01

    Cosmology in Eddington-inspired Born-Infeld gravity is investigated using a scalar Born-Infeld field (eg. tachyon condensate) as matter. In this way, both in the gravity and matter sectors we have Born-Infeld-like structures characterised by their actions and via two separate constants, $\\kappa$ and $\\alpha_T^2$ respectively. With a particular choice of the form of $\\dot{\\phi}$ (time derivative of the Born-Infeld scalar), analytical cosmological solutions are found. Thereafter, we explore some of the unique features of the corresponding cosmological spacetimes. For $\\kappa>0$, our solution has a de Sitter-like expansion both at early and late times, with an intermediate deceleration sandwiched between the accelerating phases. On the other hand, when $\\kappa0$ solution, are as good as in $\\Lambda$CDM cosmology. However, the $\\kappa<0$ solution has to be discarded due to the occurrence of a bounce at an unacceptably low redshift.

  11. Born : vastutustundlikud tulevikus edukad / Kerstin Born ; interv. Kristo Kiviorg

    Index Scriptorium Estoniae

    Born, Kerstin

    2007-01-01

    Vastutustundliku ettevõtluse Euroopa organisatsiooni CSR Europe'i juht Kerstin Born vastab küsimustele ettevõtete vastutustundlikkuse kohta ühiskonnas. Vt. samas: Käivitus vastutustundliku ettevõtluse indeks

  12. Born Rule and Noncontextual Probability

    CERN Document Server

    Logiurato, Fabrizio

    2012-01-01

    The probabilistic rule that links the formalism of Quantum Mechanics (QM) to the real world was stated by Born in 1926. Since then, there were many attempts to derive the Born postulate as a theorem, Gleason's one being the most prominent. The Gleason derivation, however, is generally considered as rather intricate and its physical meaning, in particular in relation with the noncontextuality of probability (NP), is not quite evident. More recently, we are witnessing a revival of interest on possible demonstrations of the Born rule, like Zurek's and Deutsch's based on the decoherence and on the theory of decisions, respectively. Despite an ongoing debate about the presence of hidden assumptions and circular reasonings, these have the merit of prompting more physically oriented approaches to the problem. Here we suggest a new proof of the Born rule based on the noncontextuality of probability. Within the theorem we also demonstrate the continuity of probability with respect to the amplitudes, which has been sug...

  13. Conditional reduction of adult born doublecortin-positive neurons reversibly impairs selective behaviours

    Directory of Open Access Journals (Sweden)

    Lillian eGarrett

    2015-11-01

    Full Text Available Adult neurogenesis occurs in the adult mammalian subventricular zone (SVZ along the walls of the lateral ventricles and the subgranular zone (SGZ of the hippocampal dentate gyrus. While a burgeoning body of research implicates adult neurogenesis in olfactory bulb (OB - and hippocampal-related behaviors, the precise function continues to elude. To further assess the behavioral importance of adult neurogenesis, we herein generated a novel inducible transgenic mouse model of adult neurogenesis reduction where mice with CreERT2 under doublecortin (DCX promoter control were crossed with mice where diphtheria toxin A (DTA was driven by the Rosa26 promoter. Activation of DTA, through the administration of tamoxifen (TAM, results in a specific reduction of DCX+ immature neurons in both the hippocampal dentate gyrus and OB. We show that the decrease of DCX+ cells causes impaired social discrimination ability in both young adult (from 3 months and middle (from 10 months aged mice. Furthermore, these animals showed an age-independent altered coping behavior in the Forced Swim Test without clear changes in anxiety-related behavior. Notably, these behavior changes were reversible on repopulating the neurogenic zones with DCX+ cells on cessation of the tamoxifen treatment, demonstrating the specificity of this effect. Overall, these results support the notion that adult neurogenesis plays a role in social memory and in stress coping but not necessarily in anxiety-related behavior.

  14. Antimicrobial Impacts of Essential Oils on Food Borne-Pathogens.

    Science.gov (United States)

    Ozogul, Yesim; Kuley, Esmeray; Ucar, Yilmaz; Ozogul, Fatih

    2015-01-01

    The antimicrobial activity of twelve essential oil (pine oil, eucalyptus, thyme, sage tea, lavender, orange, laurel, lemon, myrtle, lemon, rosemary and juniper) was tested by a disc diffusion method against food borne pathogens (Escherichia coli, Salmonella paratyphi A, Klebsiella pneumoniae, Yersinia enterocolitica, Pseudomonas aeruginosa, Aeromonas hydrophila, Campylobacter jejuni, Enterococcus faecalis, Staphylococcus aureus). The major components in essential oils were monoterpenes hydrocarbons, α-pinene, limonene; monoterpene phenol, carvacrol and oxygenated monoterpenes, camphor, 1,8-cineole, eucalyptol, linalool and linalyl acetate. Although the antimicrobial effect of essential oils varied depending on the chemical composition of the essential oils and specific microorganism tested, majority of the oils exhibited antibacterial activity against one or more strains. The essential oil with the lowest inhibition zones was juniper with the values varied from 1.5 to 6 mm. However, the components of essential oil of thyme and pine oil are highly active against food borne pathogen, generating the largest inhibition zones for both gram negative and positive bacteria (5.25-28.25 mm vs. 12.5-30 mm inhibition zones). These results indicate the possible use of the essential oils on food system as antimicrobial agents against food-borne pathogen. The article also offers some promising patents on applications of essential oils on food industry as antimicrobial agent. PMID:26072990

  15. Melanin-concentrating hormone (MCH) immunoreactivity in non-neuronal cells within the raphe nuclei and subventricular region of the brainstem of the cat.

    Science.gov (United States)

    Torterolo, Pablo; Lagos, Patricia; Sampogna, Sharon; Chase, Michael H

    2008-05-19

    Neurons that utilize melanin-concentrating hormone (MCH) as a neuromodulator are localized within the postero-lateral hypothalamus and zona incerta. These neurons project diffusely throughout the central nervous system and have been implicated in critical physiological processes such as energy homeostasis and sleep. In the present report, we examined the distribution of MCH immunoreactivity in the brainstem of the cat. In addition to MCH+ axons, we found MCH-immunoreactive cells that have not been previously described either in the midbrain raphe nuclei or in the periaqueductal and periventricular areas. These MCH+ cells constituted: 1. ependymal cells that lined the fourth ventricle and aqueduct, 2. ependymal cells with long basal processes that projected deeply into the subventricular (subaqueductal) parenchyma, and, 3. cells in subventricular regions and the midbrain raphe nuclei. The MCH+ cells in the midbrain raphe nuclei were closely related to neuronal processes of serotonergic neurons. Utilizing Neu-N and GFAP immunohistochemistry we determined that the preceding MCH+ cells were neither neurons nor astrocytes. However, we found that vimentin, an intermediate-filament protein that is used as a marker for tanycytes, was specifically co-localized with MCH in these cells. We conclude that MCH is present in tanycytes whose processes innervate the midbrain raphe nuclei and adjacent subependymal regions. Because tanycytes are specialized cells that transport substances from the cerebrospinal fluid (CSF) to neural parenchyma, we suggest that MCH is absorbed from the CSF by tanycytes and subsequently liberate to act upon neurons of brainstem nuclei. PMID:18410908

  16. Adult Neurogenesis in the Mammalian Hippocampus: Why the Dentate Gyrus?

    Science.gov (United States)

    Drew, Liam J.; Fusi, Stefano; Hen, René

    2013-01-01

    In the adult mammalian brain, newly generated neurons are continuously incorporated into two networks: interneurons born in the subventricular zone migrate to the olfactory bulb, whereas the dentate gyrus (DG) of the hippocampus integrates locally born principal neurons. That the rest of the mammalian brain loses significant neurogenic capacity…

  17. GABA(A) Increases Calcium in Subventricular Zone Astrocyte-Like Cells Through L- and T-Type Voltage-Gated Calcium Channels

    DEFF Research Database (Denmark)

    Young, Stephanie Z; Platel, Jean-Claude; Nielsen, Jakob V;

    2010-01-01

    induced Ca(2+) increases in 40-50% of SVZ astrocytes. GABA(A)-induced Ca(2+) increases were prevented with nifedipine and mibefradil, blockers of L- and T-type voltage-gated calcium channels (VGCC). The L-type Ca(2+) channel activator BayK 8644 increased the percentage of GABA(A)-responding astrocyte...

  18. The neural elements in the lining of the ventricular-subventricular zone: making an old story new by high-resolution scanning electron microscopy

    Directory of Open Access Journals (Sweden)

    Carlos Alexandre Dos Santos Haemmerle

    2015-10-01

    Full Text Available The classical description of the neural elements that compose the lining of brain ventricles introduces us to the single layer of ependymal cells. However, new findings, especially in the lateral ventricle - the major niche for the generation of new neurons in the adult brain - have provided information about additional cell elements that influence the organization of this part of the ventricular system and produce important contributions to neurogenesis. To complement the cell neurochemistry findings, we present a three-dimensional in situ description that demonstrates the anatomical details of the different types of ciliated cells and the innervation of these elements. After processing adult rat brains for ultrastructural analysis by high-resolution scanning electron microscopy and transmission electron microscopy, we observed a heterogeneous pattern of cilia distribution at the different poles of the lateral ventricle surface. Furthermore, we describe the particular three-dimensional aspects of the ciliated cells of the lateral ventricle, in addition the fiber bundles and varicose axons surrounding these cells. Therefore, we provide a unique ultrastructural description of the three-dimensional in situ organization of the lateral ventricle surface, highlighting its innervation, to corroborate the available neurochemical and functional findings regarding the factors that regulate this neurogenic niche.

  19. Effect of leukemia inhibitory factor on long-term propagation of precursor cells derived from rat forebrain subventricular zone and ventral mesencephalon

    DEFF Research Database (Denmark)

    Andersen, Rikke K; Zimmer, Jens; Wahlberg, Lars U; Meyer, Morten

    2008-01-01

    different immunohistochemical markers, we observed a distinct compartmentalization of cells within the spheres. In SVZ-derived NTS an outer compartment of proliferating (nestin(+)/Ki67(+)), preferentially neurogenic (beta-tubulin III(+)/MAP2(+)) cells, surrounded by an inner compartment of glial (GFAP...

  20. Born-Infeld Phantom Gravastars

    OpenAIRE

    Bilic, Neven; Tupper, Gary B.; Viollier, Raoul D.

    2005-01-01

    We construct new gravitational vacuum star solutions with a Born-Infeld phantom replacing the de Sitter interior. The model allows for a wide range of masses and radii required by phenomenology, and can be motivated from low energy string theory.

  1. Horizon structure and shadow of rotating Einstein-Born-Infeld black holes

    Science.gov (United States)

    Atamurotov, Farruh

    2016-07-01

    We investigate the horizon structure of the rotating Einstein-Born-Infeld solution which goes over to the Einstein-Maxwell's Kerr-Newman solution as the Born-Infeld parameter goes to innity ( ! 1). We nd that for a given , mass M and charge Q, there exist critical spinning parameter aE and rEH, which corresponds to an extremal Einstein-Born-Infeld black hole with degenerate horizons, and aE decreases and rEH increases with increase in the Born-Infeld parameter . While a shadow as an optical appearance due to its strong gravitational eld. We also investigate the shadow cast by the rotating Einstein- Born-Infeld black hole and demonstrate that the null geodesic equations can be integrated that allows us to investigate the shadow cast by a black hole which is found to be a dark zone covered by a circle. Interestingly, the shadows of Einstein-Born-Infeld black hole is slightly smaller than for the Reissner-Nordstrom black hole which are concentric circles, for different values of the Born-Infeld parameter , whose radius decreases with increase in the value of parameter . The shadows for the rotating Einstein-Born-Infeld solution are also included.

  2. Born-Infeld gravity in three dimensions

    International Nuclear Information System (INIS)

    In this paper we explore different aspects of three dimensional Born-Infeld as well as Born-Infeld-Chern-Simons gravity. We show that the models have anti-de Sitter and anti-de Sitter wave vacuum solutions. Moreover, we observe that although Born-Infeld-Chern-Simons gravity admits a logarithmic solution, Born-Infeld gravity does not, though it has a limiting logarithmic solution as we approach the critical point.

  3. Brand Building of Born Globals

    OpenAIRE

    Cederäng, Jesper; Norberg, Markus

    2008-01-01

    Abstract The purpose of this thesis was to increase the understanding of two early internationalizing firms (Born Globals) brand building efforts. By performing case studies on these companies we wished to discover similarities and differences in their marketing efforts. The companies that we studied were CTEK Sweden AB, a battery charger manufacturer and POC Sweden AB, who designs advanced protective gear for the alpine ski market. The theoretical framework was divided according to the four ...

  4. Detection of Water Borne Protozoa

    DEFF Research Database (Denmark)

    Al-Sabi, Mohammad Nafi Solaiman; Enemark, Heidi L.; Kurtzhals, J.A.L.

    Protozoa of several species play a key role in water borne outbreaks of diarrhea worldwide. Identification of such protozoa depends mainly on parasite detection. However, water contains several hundreds of thousands of microorganisms belonging to different taxa. The exact identification of...... pathogenic protozoa relies on selective isolation and detection that is conducted by experienced technicians. Advanced techniques such as immuno-fluorescent dyes, polymerase chain reaction, and many other techniques, may be used for species-specific identification of pathogenic protozoa. Each diagnostic...... parasitic protozoa from other organisms in the aquatic environment....

  5. Born Under a Lucky Star?

    OpenAIRE

    Nobuyuki Hanaki; Alan Kirman; Matteo Marsili

    2009-01-01

    This paper suggests that people can learn to behave in a way which makes them unlucky or lucky. Learning from experience will lead them to make choices which may lead to "luckier" outcomes than others. By so doing they may reinforce the choices of those who find themselves with unlucky outcomes. In this situation, people have reasonably learned to behave as they do and their behaviour is consistent with their experience. The lucky ones were not "born under a lucky star" they learned to be lucky.

  6. Mosquito-borne viruses in Europe

    Czech Academy of Sciences Publication Activity Database

    Hubálek, Zdeněk

    Berlin: Umweltbundesamt, 2007, s. 23-27. [Vector-borne diseases: impact of climate change on vectors and rodent reservoirs. Berlin (DE), 27.09.2007-28.09.2007] R&D Projects: GA AV ČR IAA600930611 Institutional research plan: CEZ:AV0Z60930519 Keywords : Vector-borne diseases * Europe Subject RIV: EE - Microbiology, Virology http://www.umweltbundesamt.de/gesundheit-e/veranstaltungen/vector-borne-diseases/06_%20Hubalek.pdf

  7. Tick borne encephalitis without cerebrospinal fluid pleocytosis

    OpenAIRE

    Stupica, Daša; Strle, Franc; Avšič-Županc, Tatjana; Logar, Mateja; Pečavar, Blaž; Bajrović, Fajko F.

    2014-01-01

    Background Tick borne encephalitis is the most frequent vector-transmitted infectious disease of the central nervous system in Europe and Asia. The disease caused by European subtype of tick borne encephalitis virus has typically a biphasic clinical course with the second phase presenting as meningitis, meningoencephalitis, or meningoencephalomyelitis. Cerebrospinal fluid pleocytosis is considered a condition sine qua non for the diagnosis of neurologic involvement in tick borne encephalitis,...

  8. Conceptualizing Innovation in Born Global Firms

    DEFF Research Database (Denmark)

    Zijdemans, Erik; Tanev, Stoyan

    2014-01-01

    This research provides insights from recent literature on innovativeness in the environment of born globals. This article will be relevant to researchers interested in born globals and their business environments and, more specifically, the role that innovation plays in their foundation and...... development. After discussing the internationalization of born globals as an innovation itself and the positive effect that innovation and internationalization have on each other, this article elaborates on the effect of innovativeness on the development of the company and, more in depth, the role of...... knowledge acquisition, networking capabilities and the lean startup approach in born global innovation. Finally, the article addresses the issue of quantifying and measuring innovativeness....

  9. Pulsars are Born as Magnetars

    CERN Document Server

    Heras, Ricardo

    2013-01-01

    This paper suggests the idea that all neutron stars experienced at birth an ultrafast decay of their magnetic fields from their initial values to their current surface values. If the electromagnetic energy radiated during this field decay is converted into kinetic energy of the neutron star via the radiation reaction mechanism then the decay time is of the order of 10^(-4)s provided that the initial magnetic fields lie in the range of 10^(14)-10^(16)G. This means that all neutron stars are born with magnetic fields typical of magnetars. According to this model the neutron stars acquire their observed high space velocities during the birth ultrafast decay of their magnetic fields. The origin of this field decay points to magnetic instabilities occurring at the end of the birth process.

  10. Blood Borne Hepatitis at Hajj

    Directory of Open Access Journals (Sweden)

    Harunor Rashid

    2006-06-01

    Full Text Available An pilgrims estimated 2.5 million Muslims from all over the world are expected to converge in Mecca, Saudi Arabia by the end of this December for Hajj pilgrimage. Overcrowding during the largest annual mass gathering of such enormous proportions inevitably increases exposure to and risk of a variety of infections, some with pandemic potential (1. Adopting simple measures and offering appropriate immunisations to the pilgrims can prevent many of these infections. Knowledge of the nature and extent of infections however is important to implement the effective protective measures.As part of the rites of Hajj, men shave their heads although trimming the hair is also acceptable; women cut a lock of their hair. Communal use of razors or blades carries the risk of blood borne infections such as Hepatitis B, hepatitis C or HIV(2. To minimise this risk the Saudi authorities require all barbers looking after the pilgrims to be licensed but many pilgrims use the services of opportunistic makeshift barbers or help by shaving each other, often reusing their razors at the risk of transmitting blood borne virus infections. Unlike the respiratory infections that have a short incubation, infection with blood borne viruses takes much longer to manifest or indeed may remain undetected for many years while it may progress to chronic liver disease.Studies on barbers have shown a high prevalence of carriage and disease among barbers. Extrapolating from various studies Memish et al. (2003 estimated that about 10% of the barbers are carriers of hepatitis C and 4% carry hepatitis B, over a tenth of whom are in active carrier stage (3. Many pilgrims will come from areas of the world with a high endemicity of blood borne infections such as hepatitis B and/or C. To our knowledge there have not been any studies to establish the exact incidence of viral hepatitis among the pilgrims. There is an urgent need to understand the true epidemiology and to measure the burden of

  11. [Climate- and vector-borne diseases

    DEFF Research Database (Denmark)

    Bygbjerg, I.C.; Schioler, K.L.; Konradsen, F.

    2009-01-01

    The predicted changes in climate have raised concerns that vector-borne diseases may emerge or expand in tempered regions. Malaria, leishmaniasis and tick-borne illnesses are discussed in terms of climate change and their endemic potential, especially in Denmark. While climate may play an important...

  12. Literacy Skills of Children Born Preterm

    Science.gov (United States)

    Holm, Alison; Crosbie, Sharon

    2010-01-01

    Most children born preterm are considered neurologically normal and free of disability. However in follow-up studies at school age, preterm children, born without major impairment, have been shown to have lower cognitive abilities and associated academic, social and behavioural difficulties. This study investigated the literacy, phonological…

  13. Coastal zone

    International Nuclear Information System (INIS)

    The report entitled Climate Change Impacts and Adaptation : A Canadian Perspective, presents a summary of research regarding the impacts of climate change on key sectors over the past five years as it relates to Canada. This chapter on the coastal zone focuses on the impact of climate change on Canada's marine and Great Lakes coasts with tips on how to deal with the impacts associated with climate change in sensitive environments. This report is aimed at the sectors that will be most affected by adaptation decisions in the coastal zone, including fisheries, tourism, transportation and water resources. The impact of climate change in the coastal zone may include changes in water levels, wave patterns, storm surges, and thickness of seasonal ice cover. The Intergovernmental Panel on Climate Change projects global average sea level will rise between 9 and 88 centimetres between 1990 to 2100, but not all areas of Canada will experience the same rate of future sea level change. The main physical impact would be shoreline change that could result in a range of biophysical and socio-economic impacts, some beneficial, some negative. The report focuses on issues related to infrastructure and communities in coastal regions. It is noted that appropriate human adaptation will play a vital role in reducing the extent of potential impacts by decreasing the vulnerability of average zone to climate change. The 3 main trends in coastal adaptation include: (1) increase in soft protection, retreat and accommodation, (2) reliance on technology such as geographic information systems to manage information, and (3) awareness of the need for coastal adaptation that is appropriate for local conditions. 61 refs., 7 figs

  14. Calculation of distribution of effective reflection area for space-borne laser retro-reflector array

    Institute of Scientific and Technical Information of China (English)

    HU; Jingfu; LI; Xin; YANG; Fumin; CHEN; Wanzhen

    2004-01-01

    The effective area of space-borne laser retro-reflector directly influences the intensity of the return signals for satellite laser ranging. The configuration of the retro-reflector array determines the effective area. The formula for the effective area of the space-borne retro-reflector array with different inclination angles at arbitrary celestial zone was deduced in this paper. As an example, the calculation result about effective area for the retro-reflector array of the Shenzhou-IV orbital module was given.

  15. Horizon structure of rotating Einstein-Born-Infeld black holes and shadow

    Science.gov (United States)

    Atamurotov, Farruh; Ghosh, Sushant G.; Ahmedov, Bobomurat

    2016-05-01

    We investigate the horizon structure of the rotating Einstein-Born-Infeld solution which goes over to the Einstein-Maxwell's Kerr-Newman solution as the Born-Infeld parameter goes to infinity (β → ∞). We find that for a given β , mass M, and charge Q, there exist a critical spinning parameter aE and rHE, which corresponds to an extremal Einstein-Born-Infeld black hole with degenerate horizons, and aE decreases and rHE increases with increase of the Born-Infeld parameter β , while ahole with outer and inner horizons. Similarly, the effect of β on the infinite redshift surface and in turn on the ergo-region is also included. It is well known that a black hole can cast a shadow as an optical appearance due to its strong gravitational field. We also investigate the shadow cast by the both static and rotating Einstein-Born-Infeld black hole and demonstrate that the null geodesic equations can be integrated, which allows us to investigate the shadow cast by a black hole which is found to be a dark zone covered by a circle. Interestingly, the shadow of an Einstein-Born-Infeld black hole is slightly smaller than for the Reissner-Nordstrom black hole, which consists of concentric circles, for different values of the Born-Infeld parameter β , whose radius decreases with increase of the value of the parameter β . Finally, we have studied observable distortion parameter for shadow of the rotating Einstein-Born-Infeld black hole.

  16. New neurons in the adult brain : The role of sleep and consequences of sleep loss

    NARCIS (Netherlands)

    Meerlo, Peter; Mistiberger, Ralph E.; Jacobs, Barry L.; Heller, H. Craig; McGinty, Dennis; Mistlberger, Ralph E.

    2009-01-01

    Research over the last few decades has firmly established that new neurons are generated in selected areas of the adult mammalian brain, particularly the dentate gyrus of the hippocampal formation and the subventricular zone of the lateral ventricles. The function of adult-born neurons is still a ma

  17. A brain slice culture model for studies of endogenous and exogenous precursor cell migration in the rostral migratory stream

    DEFF Research Database (Denmark)

    Tanvig, Mette; Blaabjerg, Morten; Andersen, Rikke K;

    2009-01-01

    The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone (SVZ) cells reach the olfactory bulb (OB) in rodents. This migration has been well studied in vivo, but an organotypic in vitro model would facilitate more experimental investigations. Here we introduce...

  18. Potato soil-borne diseases. A review

    OpenAIRE

    Fiers, Marie; Edel-Hermann, Veronique; Chatot, Catherine; Le Hingrat, Yves; ALABOUVETTE, Claude; Steinberg, Christian

    2012-01-01

    Potato crop is the fourth main food crop in the world and it will certainly feed a big part of the global population in the next years. The economical outlets for this crop are great; however, numerous diseases either soil- or air-borne can cause huge losses in the production. Worldwide, about 40 soil-borne diseases affect potato and cause severe damages especially on tubers, the economically most important part of the plant. The occurrence and development of soil-borne diseases depend on ver...

  19. Tick-Borne Diseases: The Big Two

    Science.gov (United States)

    ... Ticks and Diseases Tick-borne Diseases: The Big Two Past Issues / Spring - Summer 2010 Table of Contents ... muscle pain. The red-spotted rash usually happens 2 to 5 days after the fever begins. Antibiotics ...

  20. Photonic processes in Born-Infeld theory

    Science.gov (United States)

    Dávila, José Manuel; Schubert, Christian; Trejo, María Anabel

    2014-12-01

    We study the processes of photon-photon scattering and photon splitting in a magnetic field in Born-Infeld theory. In both cases we combine the terms from the tree-level Born-Infeld Lagrangian with the usual one-loop QED contributions, where those are approximated by the Euler-Heisenberg Lagrangian, including also the interference terms. For photon-photon scattering we obtain the total cross-section in the low-energy approximation. For photon splitting we compute the total absorption coefficient in the hexagon (weak field) approximation, and also show that, due to the non-birefringence property of Born-Infeld theory, the selection rules found by Adler for the QED case continue to hold in this more general setting. We discuss the bounds on the free parameter of Born-Infeld theory that may be obtained from this type of processes.

  1. Photonic processes in Born-Infeld theory

    CERN Document Server

    Davila, Jose Manuel; Trejo, Maria Anabel

    2013-01-01

    We study the processes of photon-photon scattering and photon splitting in a magnetic field in Born-Infeld theory. In both cases we combine the terms from the tree-level Born-Infeld Lagrangian with the usual one-loop QED contributions, where those are approximated by the Euler-Heisenberg Lagrangian, including also the interference terms. For photon-photon scattering we obtain the total cross section in the low-energy approximation. For photon splitting we compute the total absorption coefficient in the hexagon (weak field) approximation, and also show that, due to the non-birefringence property of Born-Infeld theory, the selection rules found by Adler for the QED case continue to hold in this more general setting. We discuss the bounds on the free parameter of Born-Infeld theory that may be obtained from this type of processes.

  2. Born-Infeld Gravity in any Dimension

    OpenAIRE

    Nieto, J.A.

    2004-01-01

    We develop a Born-Infeld type theory for gravity in any dimension. We show that in four dimensions our formalism allows a self-dual (or anti-self dual) Born-Infeld gravity description. Moreover, we show that such a self-dual action is reduced to both the Deser-Gibbons and the Jacobson-Smolin-Samuel action of Ashtekar formulation. A supersymmetric generalization of our approach is outlined.

  3. Flea-borne rickettsioses: ecologic considerations.

    OpenAIRE

    Azad, A F; Radulovic, S; Higgins, J. A.; Noden, B. H.; Troyer, J. M.

    1997-01-01

    Ecologic and economic factors, as well as changes in human behavior, have resulted in the emergence of new and the reemergence of existing but forgotten infectious diseases during the past 20 years. Flea-borne disease organisms (e.g., Yersinia pestis, Rickettsia typhi, R. felis, and Bartonella henselae) are widely distributed throughout the world in endemic-disease foci, where components of the enzootic cycle are present. However, flea-borne diseases could reemerge in epidemic form because of...

  4. 2D Born-Infeld electrostatic fields

    OpenAIRE

    Ferraro, Rafael

    2003-01-01

    The electrostatic configurations of the Born-Infeld field in the 2-dimensional Euclidean plane are obtained by means of a non-analytical complex mapping which captures the structure of equipotential and field lines. The electrostatic field reaches the Born-Infeld limit value when the field lines become tangent to an epicycloid around the origin. The total energy by unit of length remains finite.

  5. Foreign-born Peers and Academic Performance.

    Science.gov (United States)

    Conger, Dylan

    2015-04-01

    The academic performance of foreign-born youth in the United States is well studied, yet little is known about whether and how foreign-born students influence their classmates. In this article, I develop a set of expectations regarding the potential consequences of immigrant integration across schools, with a distinction between the effects of sharing schools with immigrants who are designated as English language learners (ELL) and those who are not. I then use administrative data on multiple cohorts of Florida public high school students to estimate the effect of immigrant shares on immigrant and native-born students' academic performance. The identification strategy pays careful attention to the selection problem by estimating the effect of foreign-born peers from deviations in the share foreign-born across cohorts of students attending the same school in different years. The assumption underlying this approach is that students choose schools based on the composition of the entire school, not on the composition of each entering cohort. The results of the analysis, which hold under several robustness checks, indicate that foreign-born peers (both those who are ELL and those who are non-ELL) have no effect on their high school classmates' academic performance. PMID:25651879

  6. Born Sensitivity Kernels in Spherical Geometry for Meridional Flows

    Science.gov (United States)

    Jackiewicz, Jason; Boening, Vincent; Roth, Markus; Kholikov, Shukur

    2016-05-01

    Measuring meridional flows deep in the solar convection zone is challenging because of their small amplitudes compared to other background signals. Typically such inferences are made using a ray theory that is best suited for slowly-varying flows. The implementation of finite-frequency Born theory has been shown to be more accurate for modeling flows of complex spatial structure in the near-surface region. Only until recently were such functions available in spherical geometry, which is necessary for applications to meridional flows. Here we compare these sensitivity kernels with corresponding ray kernels in a forward and inverse problem using numerical simulations. We show that they are suitable for inverting travel-time measurements and are more sensitive to small-scale variations of deep circulations.

  7. Urbanization, land tenure security and vector-borne Chagas disease

    Science.gov (United States)

    Levy, Michael Z.; Barbu, Corentin M.; Castillo-Neyra, Ricardo; Quispe-Machaca, Victor R.; Ancca-Juarez, Jenny; Escalante-Mejia, Patricia; Borrini-Mayori, Katty; Niemierko, Malwina; Mabud, Tarub S.; Behrman, Jere R.; Naquira-Velarde, Cesar

    2014-01-01

    Modern cities represent one of the fastest growing ecosystems on the planet. Urbanization occurs in stages; each stage characterized by a distinct habitat that may be more or less susceptible to the establishment of disease vector populations and the transmission of vector-borne pathogens. We performed longitudinal entomological and epidemiological surveys in households along a 1900 × 125 m transect of Arequipa, Peru, a major city of nearly one million inhabitants, in which the transmission of Trypanosoma cruzi, the aetiological agent of Chagas disease, by the insect vector Triatoma infestans, is an ongoing problem. The transect spans a cline of urban development from established communities to land invasions. We find that the vector is tracking the development of the city, and the parasite, in turn, is tracking the dispersal of the vector. New urbanizations are free of vector infestation for decades. T. cruzi transmission is very recent and concentrated in more established communities. The increase in land tenure security during the course of urbanization, if not accompanied by reasonable and enforceable zoning codes, initiates an influx of construction materials, people and animals that creates fertile conditions for epidemics of some vector-borne diseases. PMID:24990681

  8. Assessment of changes of vector borne diseases with wetland characteristics using multivariate analysis.

    Science.gov (United States)

    Sheela, A M; Sarun, S; Justus, J; Vineetha, P; Sheeja, R V

    2015-04-01

    Vector borne diseases are a threat to human health. Little attention has been paid to the prevention of these diseases. We attempted to identify the significant wetland characteristics associated with the spread of chikungunya, dengue fever and malaria in Kerala, a tropical region of South West India using multivariate analyses (hierarchical cluster analysis, factor analysis and multiple regression). High/medium turbid coastal lagoons and inland water-logged wetlands with aquatic vegetation have significant effect on the incidence of chikungunya while dengue influenced by high turbid coastal beaches and malaria by medium turbid coastal beaches. The high turbidity in water is due to the urban waste discharge namely sewage, sullage and garbage from the densely populated cities and towns. The large extent of wetland is low land area favours the occurrence of vector borne diseases. Hence the provision of pollution control measures at source including soil erosion control measures is vital. The identification of vulnerable zones favouring the vector borne diseases will help the authorities to control pollution especially from urban areas and prevent these vector borne diseases. Future research should cover land use cover changes, climatic factors, seasonal variations in weather and pollution factors favouring the occurrence of vector borne diseases. PMID:25412801

  9. Tornado-borne missile speeds. Final report

    International Nuclear Information System (INIS)

    An investigation of the question of tornado-borne missile speeds was carried out, with a view to identify pertinent areas of uncertainty and to estimate credible tornado-borne missile speeds - within the limitations inherent in the present state of the art. The investigation consists of two parts: (1) a study in which a rational model for the missile motion is proposed, and numerical experiments are carried out corresponding to various assumptions on the initial conditions of the missile motion, the structure of the tornado flow, and the aerodynamic properties of the missile; (2) a theoretical and experimental study of tornado-borne missile aerodynamics, conducted by Colorado State Univ. (CSU) to be covered in a separate report by CSU. In the present report, the factors affecting missile motion and their influence upon such motion are examined

  10. On transparent potentials: a Born approximation study

    International Nuclear Information System (INIS)

    In the frame of the scattering inverse problem at fixed energy, a class of potentials transparent in Born approximation is obtained. All these potentials are spherically symmetric and are oscillating functions of the reduced radial variable. Amongst them, the Born approximation of the transparent potential of the Newton-Sabatier method is found. In the same class, quasi-transparent potentials are exhibited. Very general features of potentials transparent in Born approximation are then stated. And bounds are given for the exact scattering amplitudes corresponding to most of the potentials previously exhibited. These bounds, obtained at fixed energy, and for large values of the angular momentum, are found to be independent on the energy

  11. [Conflicts and vector-borne diseases

    DEFF Research Database (Denmark)

    Bygbjerg, Ib Christian

    2010-01-01

    Based on literature and personal experiences, vector-borne diseases and conflicts are reviewed. Simple rapid diagnostic tests for three important parasitoses are available. Resort is often made to case definitions and to presumptive treatment. Resistance is an emerging problem. Vaccines are still...... not available for most diseases. Promising preventive methods, including long-lasting impregnated bed-nets and tents, are available. War has been an impetus for disclosing life-cycles of vector-borne diseases and for control methods; peace, reconciliation and poverty reduction are required to achieve...

  12. Pap Tests and Foreign-Born Women

    Centers for Disease Control (CDC) Podcasts

    2007-11-26

    Foreign-born women living in the U.S. are less likely to have Pap tests to detect cervical cancer than women born in this country. The problem is worse for women from certain countries or regions. Find out why this is a disturbing trend, who these women are and why they are less likely to get a Pap test, and what CDC is doing about it.  Created: 11/26/2007 by National Breast and Cervical Cancer Early Detection Program.   Date Released: 12/7/2007.

  13. Photonic processes in Born-Infeld theory

    OpenAIRE

    Davila, Jose Manuel; Schubert, Christian; Trejo, Maria Anabel

    2013-01-01

    We study the processes of photon-photon scattering and photon splitting in a magnetic field in Born-Infeld theory. In both cases we combine the terms from the tree-level Born-Infeld Lagrangian with the usual one-loop QED contributions, where those are approximated by the Euler-Heisenberg Lagrangian, including also the interference terms. For photon-photon scattering we obtain the total cross section in the low-energy approximation. For photon splitting we compute the total absorption coeffici...

  14. Born Toon Soon: Preterm birth matters

    OpenAIRE

    Howson, Christopher P; Mary V Kinney; McDougall, Lori; Joy E Lawn

    2013-01-01

    Urgent action is needed to address preterm birth given that the first country-level estimates show that globally 15 million babies are born too soon and rates are increasing in most countries with reliable time trend data. As the first in a supplement entitled "Born Too Soon", this paper focuses on the global policy context. Preterm birth is critical for progress on Millennium Development Goal 4 (MDG) for child survival by 2015 and beyond, and gives added value to maternal health (MDG 5) inve...

  15. Molecular Scattering and Born-Oppenheimer Approximation

    OpenAIRE

    Vania, Sordoni

    2008-01-01

    In this paper, we study the scattering wave operators for a diatomic molecules by using the Born-Oppenheimer approximation. Assuming that the ratio h^2 between the electronic and nuclear masses is small, we construct adiabatic wave operators that, under some non trapping conditions, approximate the two-cluster wave operators up to any powers of the parameter h

  16. Group Analysis of Born-Infeld Equation

    OpenAIRE

    Nadjafikhah, Mehdi; Hejazi, Seyed Reza

    2010-01-01

    Lie symmetry group method is applied to study the Born-Infeld equation. The symmetry group and its optimal system are given, and group invariant solutions associated to the symmetries are obtained. Finally the structure of the Lie algebra symmetries is determined.

  17. Relativistic bound states at Born level

    CERN Document Server

    Hoyer, Paul

    2012-01-01

    Theoretical and phenomenological studies indicate that the QCD coupling \\alpha_s(Q^2) freezes in the infrared. Hadrons may then be described by a perturbative expansion around "Born" states bound only by a confining potential. A linear potential results from the QCD equations of motion when Gauss' law for A^0 is solved with F_{\\mu\

  18. Scientific Discoveries the Year I Was Born

    Science.gov (United States)

    Cherif, Abour

    2012-01-01

    The author has successfully used a learning activity titled "The Year I Was Born" to motivate students to conduct historical research and present key scientific discoveries from their birth year. The activity promotes writing, helps students enhance their scientific literacy, and also improves their attitude toward the learning of science. As one…

  19. Spatial distribution and cellular composition of adult brain proliferative zones in the teleost, Gymnotus omarorum

    Directory of Open Access Journals (Sweden)

    Daniel A Peterson

    2014-09-01

    Full Text Available Proliferation of stem/progenitor cells during development provides for the generation of mature cell types in the CNS. While adult brain proliferation is highly restricted in the mammals, it is widespread in teleosts. The extent of adult neural proliferation in the weakly electric fish, Gymnotus omarorum has not yet been described. To address this, we used double thymidine analog pulse-chase labeling of proliferating cells to identify brain proliferation zones, characterize their cellular composition, and analyze the fate of newborn cells in adult G. omarorum. Short thymidine analog chase periods revealed the ubiquitous distribution of adult brain proliferation, similar to other teleosts, particularly Apteronotus leptorhynchus. Proliferating cells were abundant at the ventricular-subventricular lining of the ventricular-cisternal system, adjacent to the telencephalic subpallium, the diencephalic preoptic region and hypothalamus, and the mesencephalic tectum opticum and torus semicircularis. Extraventricular proliferation zones, located distant from the ventricular-cisternal system surface, were found in all divisions of the rombencephalic cerebellum. We also report a new adult proliferation zone at the caudal-lateral border of the electrosensory lateral line lobe. All proliferation zones showed a heterogeneous cellular composition. The use of short (24hs and long (30d chase periods revealed abundant fast cycling cells (potentially intermediate amplifiers, sparse slow cycling (potentially stem cells, cells that appear to have entered a quiescent state, and cells that might correspond to migrating newborn neural cells. Their abundance and migration distance differed among proliferation zones: greater numbers and longer range and/or pace of migrating cells were associated with subpallial and cerebellar proliferation zones.

  20. Investigations of Temperature and Backscatter Correlation in the Dry Snow Zone of the Greenland Ice Sheet

    OpenAIRE

    Moon, Kevin R.; Long, David G.

    2012-01-01

    Due to system degradation, satellite-borne scatterometers require post-launch calibrations to maintain accuracy. The dry snow zone of the Greenland ice sheet has been used for calibration due to its relatively constant backscatter properties. However, we recently discovered that some of the variation in the dry snow zone backscatter is seasonal. This paper uses correlation analysis to investigate the relationship between temperature and backscatter in the dry snow zone. The correlation coeffi...

  1. Zone distillation: justification

    International Nuclear Information System (INIS)

    The features of zone distillation (with zone melting of refined material and with pulling of condensate) as a new purification method are shown. The method is based on similarity of equations of distillation and crystallization refining. The analogy between some distillation and condensation methods (particularly between zone distillation and zone re-crystallization) is should up

  2. The Asset Portfolios of Native-Born and Foreign-Born Households

    OpenAIRE

    Cobb-Clark, Deborah A.; Vincent A. Hildebrand

    2008-01-01

    This paper analyses the net worth and asset portfolios of native- and foreign-born Australian families using HILDA (wave 2) data. Specifically, we estimate a system of asset equations with an adding-up constraint imposed to control for variation in households' total net worth. Our results indicate that after accounting for differences in human capital and income levels, single immigrants have a wealth advantage of almost $185,000 relative to single native-born individuals. Although the wealth...

  3. The Eco-Epidemiology of Tick-Borne Hemoparasitic Diseases Using Geographic Information Systems

    Directory of Open Access Journals (Sweden)

    Javad Rafinejad

    2013-12-01

    Full Text Available Background: Tick-borne diseases are of the most important diseases in the world including Iran. This survey was conducted to understand the eco-epidemiology of tick-borne hemoparasitic diseases in Qazvin province, Iran, using Geospatial Information System (GIS. Materials and Methods: DNA samples were extracted from livestock blood samples collected from different regions of Qazvin province. 18S rRNA-based PCR targeted Theileria/ Babesia species were done. Initial parameters for mapping the local tick-borne hemoparasitic diseases and raster files were obtained from Iran Meteorological Organization and Iranian Space Agency. Mapping of the parameters in relation to prevalence of these diseases were done. Statistical analysis was used for weighting parameters ranking and predicting spatial distribution in different climatic zones. Results: Vapor pressure, precipitation, and altitude are of several environmental factors correlated with tick abundances. Based on the generated maps and the results of this survey, some predicting results could be used for predicting tick-borne diseases and their control. 9.7% of ruminant blood samples (N=16 were infected with protozoa pathogens from the genera Theileria and all of the specimens were negative regarding to Babesia genera. Conclusion: Results showed that prediction of a very high prevalence of Theileria/ Babesia species and mapping endangered area is possible in different parts of Iran. Based on the environmental conditions, key factors exist for host-seeking and range expansion of ticks.

  4. Differences in the self-reported racism experiences of US-born and foreign-born Black pregnant women

    OpenAIRE

    Dominguez, Tyan Parker; Strong, Emily Ficklin; Krieger, Nancy; Gillman, Matthew W; Rich-Edwards, Janet W

    2009-01-01

    Differential exposure to minority status stressors may help explain differences in United States (US)-born and foreign-born Black women’s birth outcomes. We explored self-reports of racism recorded in a survey of 185 US-born and 114 foreign-born Black pregnant women enrolled in Project Viva, a prospective cohort study of pregnant women in Boston, Massachusetts, USA. Self-reported prevalence of personal racism and group racism was significantly higher among US-born than foreign-born Black preg...

  5. Geometrical dynamics of Born-Infeld objects

    Energy Technology Data Exchange (ETDEWEB)

    Cordero, Ruben [Departamento de Fisica, Escuela Superior de Fisica y Matematicas del I.P.N., Unidad Adolfo Lopez Mateos, Edificio 9, 07738 Mexico, D.F. (Mexico); Molgado, Alberto [Facultad de Ciencias, Universidad de Colima, Bernal DIaz del Castillo 340, Col. Villas San Sebastian, Colima (Mexico); Rojas, Efrain [Facultad de Fisica e Inteligencia Artificial, Universidad Veracruzana, 91000 Xalapa, Veracruz (Mexico)

    2007-03-21

    We present a geometrically inspired study of the dynamics of Dp-branes. We focus on the usual non-polynomial Dirac-Born-Infeld action for the worldvolume swept out by the brane in its evolution in general background spacetimes. We emphasize the form of the resulting equations of motion which are quite simple and resemble Newton's second law, complemented with a conservation law for a worldvolume bicurrent. We take a closer look at the classical Hamiltonian analysis which is supported by the ADM framework of general relativity. The constraints and their algebra are identified as well as the geometrical role they play in phase space. In order to illustrate our results, we review the dynamics of a D1-brane immersed in a AdS{sub 3} x S{sup 3} background spacetime. We exhibit the mechanical properties of Born-Infeld objects paving the way to a consistent quantum formulation.

  6. Risk based surveillance for vector borne diseases

    DEFF Research Database (Denmark)

    Bødker, Rene

    and new exotic diseases like Usutu and West Nile Virus may lead to outbreaks in the region. In the worst case the combined effect of climate change and globalization may potentially lead to European outbreaks of important zoonotic mosquito borne infections like Rift Valley Fever in cattle and Japanese...... Encephalitis in swine. Being able to model the impact of climate and environmental change on the transmission intensity of vector borne diseases is potentially a powerful tool to both monitor and prevent outbreaks in a cost effective way. The recent unexpected outbreaks of bluetongue and Schmallenberg virus...... is the direct result of climate change. The potential for virus transmission by biting midges was here modeled monthly for the Baltic See Region and the rest of Europe. The results showed that Baltic See Region has a lower transmission potential than most other areas in Europe. And the model identified...

  7. Attitude determination for balloon-borne experiments

    CERN Document Server

    Gandilo, N N; Amiri, M; Angile, F E; Benton, S J; Bock, J J; Bond, J R; Bryan, S A; Chiang, H C; Contaldi, C R; Crill, B P; Devlin, M J; Dober, B; Dore, O P; Farhang, M; Filippini, J P; Fissel, L M; Fraisse, A A; Fukui, Y; Galitzki, N; Gambrel, A E; Golwala, S; Gudmundsson, J E; Halpern, M; Hasselfield, M; Hilton, G C; Holmes, W A; Hristov, V V; Irwin, K D; Jones, W C; Kermish, Z D; Klein, J; Korotkov, A L; Kuo, C L; MacTavish, C J; Mason, P V; Matthews, T G; Megerian, K G; Moncelsi, L; Morford, T A; Mroczkowski, T K; Nagy, J M; Netterfield, C B; Novak, G; Nutter, D; O'Brient, R; Pascale, E; Poidevin, F; Rahlin, A S; Reintsema, C D; Ruhl, J E; Runyan, M C; Savini, G; Scott, D; Shariff, J A; Soler, J D; Thomas, N E; Trangsrud, A; Truch, M D; Tucker, C E; Tucker, G S; Tucker, R S; Turner, A D; Ward-Thompson, D; Weber, A C; Wiebe, D V; Young, E Y

    2014-01-01

    An attitude determination system for balloon-borne experiments is presented. The system provides pointing information in azimuth and elevation for instruments flying on stratospheric balloons over Antarctica. In-flight attitude is given by the real-time combination of readings from star cameras, a magnetometer, sun sensors, GPS, gyroscopes, tilt sensors and an elevation encoder. Post-flight attitude reconstruction is determined from star camera solutions, interpolated by the gyroscopes using an extended Kalman Filter. The multi-sensor system was employed by the Balloon-borne Large Aperture Submillimeter Telescope for Polarimetry (BLASTPol), an experiment that measures polarized thermal emission from interstellar dust clouds. A similar system was designed for the upcoming flight of SPIDER, a Cosmic Microwave Background polarization experiment. The pointing requirements for these experiments are discussed, as well as the challenges in designing attitude reconstruction systems for high altitude balloon flights. ...

  8. Advanced sleep phase in adolescents born preterm.

    Science.gov (United States)

    Hibbs, Anna Maria; Storfer-Isser, Amy; Rosen, Carol; Ievers-Landis, Carolyn E; Taveras, Elsie M; Redline, Susan

    2014-09-01

    The objective of this article is to evaluate whether sleep patterns and quality differed between adolescents born preterm and term, and to further explore whether differences in sleep patterns were explained by differences in mediating factors such as mood, behavior, or socioeconomic status. Five hundred and one 16- to 19-year-old children in the longitudinal Cleveland Children's Sleep and Health Study cohort underwent overnight polysomnography (PSG), wore wrist actigraphs, and completed sleep logs for 1 week. The modified Epworth Sleepiness Scale, the Adolescent Sleep Hygiene Scale, and the Adolescent Sleep-Wake Scale were used to further assess sleep. Adolescents born preterm demonstrated significantly (p parenting styles on children's sleep. PMID:24283662

  9. Symbiotic control of mosquito borne disease.

    Science.gov (United States)

    Ricci, Irene; Valzano, Matteo; Ulissi, Ulisse; Epis, Sara; Cappelli, Alessia; Favia, Guido

    2012-11-01

    It is well accepted that the symbiotic relationships insects have established with several microorganisms have had a key role in their evolutionary success. Bacterial symbiosis is also prevalent in insects that are efficient disease vectors, and numerous studies have sought to decrypt the basic mechanisms of the host-symbiont relationships and develop ways to control vector borne diseases. 'Symbiotic control', a new multifaceted approach that uses symbiotic microorganisms to control insect pests or reduce vector competence, seems particularly promising. Three such approaches currently at the cutting edge are: (1) the disruption of microbial symbionts required by insect pests; (2) the manipulation of symbionts that can express anti-pathogen molecules within the host; and (3) the introduction of endogenous microbes that affect life-span and vector capacity of the new hosts in insect populations. This work reviews current knowledge on microbial symbiosis in mosquitoes that holds promise for development of symbiotic control for mosquito borne diseases. PMID:23265608

  10. Geometrical dynamics of Born-Infeld objects

    International Nuclear Information System (INIS)

    We present a geometrically inspired study of the dynamics of Dp-branes. We focus on the usual non-polynomial Dirac-Born-Infeld action for the worldvolume swept out by the brane in its evolution in general background spacetimes. We emphasize the form of the resulting equations of motion which are quite simple and resemble Newton's second law, complemented with a conservation law for a worldvolume bicurrent. We take a closer look at the classical Hamiltonian analysis which is supported by the ADM framework of general relativity. The constraints and their algebra are identified as well as the geometrical role they play in phase space. In order to illustrate our results, we review the dynamics of a D1-brane immersed in a AdS3 x S3 background spacetime. We exhibit the mechanical properties of Born-Infeld objects paving the way to a consistent quantum formulation

  11. Non-linear 3-D Born shear waveform tomography in Southeast Asia

    Science.gov (United States)

    Panning, Mark P.; Cao, Aimin; Kim, Ahyi; Romanowicz, Barbara A.

    2012-07-01

    Southeast (SE) Asia is a tectonically complex region surrounded by many active source regions, thus an ideal test bed for developments in seismic tomography. Much recent development in tomography has been based on 3-D sensitivity kernels based on the first-order Born approximation, but there are potential problems with this approach when applied to waveform data. In this study, we develop a radially anisotropic model of SE Asia using long-period multimode waveforms. We use a theoretical 'cascade' approach, starting with a large-scale Eurasian model developed using 2-D Non-linear Asymptotic Coupling Theory (NACT) sensitivity kernels, and then using a modified Born approximation (nBorn), shown to be more accurate at modelling waveforms, to invert a subset of the data for structure in a subregion (longitude 75°-150° and latitude 0°-45°). In this subregion, the model is parametrized at a spherical spline level 6 (˜200 km). The data set is also inverted using NACT and purely linear 3-D Born kernels. All three final models fit the data well, with just under 80 per cent variance reduction as calculated using the corresponding theory, but the nBorn model shows more detailed structure than the NACT model throughout and has much better resolution at depths greater than 250 km. Based on variance analysis, the purely linear Born kernels do not provide as good a fit to the data due to deviations from linearity for the waveform data set used in this modelling. The nBorn isotropic model shows a stronger fast velocity anomaly beneath the Tibetan Plateau in the depth range of 150-250 km, which disappears at greater depth, consistent with other studies. It also indicates moderate thinning of the high-velocity plate in the middle of Tibet, consistent with a model where Tibet is underplated by Indian lithosphere from the south and Eurasian lithosphere from the north, in contrast to a model with continuous underplating by Indian lithosphere across the entire plateau. The nBorn

  12. Outbreaks of food-borne and waterborne viral gastroenteritis.

    OpenAIRE

    Hedberg, C W; Osterholm, M T

    1993-01-01

    Norwalk virus infection is the epidemiologic prototype for outbreaks of food-borne and waterborne gastroenteritis. Around the world, Norwalk virus and Norwalk-like viruses appear to be major causes of food-borne and waterborne illness. Assessment of the overall significance of viral agents to the epidemiology of food-borne and waterborne illness is hampered by the lack of surveillance throughout much of the world. In areas where food-borne and waterborne illness surveillance is conducted, out...

  13. Distribution of tick-borne diseases in China

    OpenAIRE

    Wu, Xian-Bo; Na, Ren-Hua; Wei, Shan-Shan; Zhu, Jin-Song; Peng, Hong-Juan

    2013-01-01

    Abstract As an important contributor to vector-borne diseases in China, in recent years, tick-borne diseases have attracted much attention because of their increasing incidence and consequent significant harm to livestock and human health. The most commonly observed human tick-borne diseases in China include Lyme borreliosis (known as Lyme disease in China), tick-borne encephalitis (known as Forest encephalitis in China), Crimean-Congo hemorrhagic fever (known as Xinjiang hemorrhagic fever in...

  14. Quantum heat transfer: A Born Oppenheimer method

    OpenAIRE

    Wu, Lian-Ao; Segal, Dvira

    2010-01-01

    We develop a Born-Oppenheimer type formalism for the description of quantum thermal transport along hybrid nanoscale objects. Our formalism is suitable for treating heat transfer in the off-resonant regime, where e.g., the relevant vibrational modes of the interlocated molecule are high relative to typical bath frequencies, and at low temperatures when tunneling effects dominate. A general expression for the thermal energy current is accomplished, in the form of a generalized Landauer formula...

  15. Dynamics of Born-Infeld membranes

    Energy Technology Data Exchange (ETDEWEB)

    Cordero, R [Departamento de Fisica, Escuela Superior de Fisica y Matematicas del I.P.N., Unidad Adolfo Lopez Mateos, Edificio 9, 07738 Mexico, D.F. (Mexico); Molgado, A [Facultad de Ciencias, Universidad de Colima, Bernal DIaz del Castillo 340, Col. Villas San Sebastian, Colima (Mexico); Rojas, E [Facultad de Fisica e Inteligencia Artificial, Universidad Veracruzana, 91000 Xalapa, Veracruz (Mexico)

    2007-11-15

    We present a geometrical inspired study of the dynamics of Dp-branes. We focus on the usual nonpolynomial Dirac-Born-Infeld action for the worldvolume swept out by the brane in its evolution in general background spacetimes. We emphasize the form of the resulting equations of motion which are quite simple and resemble Newton's second law, complemented with a conservation law for a worldvolume bicurrent.

  16. Climate change and mosquito-borne disease.

    OpenAIRE

    Reiter, P.

    2001-01-01

    Global atmospheric temperatures are presently in a warming phase that began 250--300 years ago. Speculations on the potential impact of continued warming on human health often focus on mosquito-borne diseases. Elementary models suggest that higher global temperatures will enhance their transmission rates and extend their geographic ranges. However, the histories of three such diseases--malaria, yellow fever, and dengue--reveal that climate has rarely been the principal determinant of their pr...

  17. Suppression of soil-borne plant pathogens

    OpenAIRE

    Agtmaal, van, E.L.

    2015-01-01

    Soil borne plant pathogens considerably reduce crop yields worldwide and are difficult to control due to their ”masked” occurrence  in the heterogeneous soil environment. This hampers the efficacy of chemical - and microbiological control agents.   Outbreaks of crop diseases are not only dependent on the presence of pathogen propagules in the soil, but are also influenced by soil-related properties like physico-chemical characteristics, microbial activity and commun...

  18. Teenagers born at extremely low birth weight

    OpenAIRE

    Whitfield, Michael F.; Grunau, Ruth E

    2006-01-01

    Adolescence constitutes a major transition for extremely low birth weight (ELBW) teenagers. Recent studies of ELBW teenagers born in the 1980s have provided information about the growth and developmental characteristics of these individuals in adolescence and in early adulthood. ELBW teenagers are shorter and lighter than their full-term peers, and have a smaller head circumference. Cognitive and academic vulnerabilities documented during the school years, particularly difficulties with nonve...

  19. Operatorial quantization of Born-Infeld Skyrmions

    CERN Document Server

    Neto, J A; Oliveira, W; Neto, Jorge Ananias; Oliveira, Emanuel R. de; Oliveira, Wilson

    1999-01-01

    The SU(2) collective coordinates quantization of the Born-Infeld Skyrmions Lagrangean is performed. The obtainment of the classical Hamiltonian from this special Lagrangean is made by using an approximate way: it is derived from the expansion of this non-polynomial Lagrangean up to second-order variable in the collective coordinates, using for this some causality arguments. Because this system presents constraints, we use the Dirac Hamiltonian method and the Faddeev-Jackiw Lagrangean approach to quantize this model.

  20. Inside the boardroom of born globals

    OpenAIRE

    Solberg, Carl Arthur; Bretteville, Trine

    2012-01-01

    This study addresses the roles of the board of directors and explores the relationships between the founder(s) and investors over the life cycle of the born global. More specifically, we posit that different interests between the founder and professional investors make the BG particularly vulnerable to faulty processes within the board. These issues are explored in three Norwegian BGs with different risk and ownership profiles. We find that: 1) conflicts are much more rife in fast growing BGs...

  1. Dynamics of Born-Infeld membranes

    International Nuclear Information System (INIS)

    We present a geometrical inspired study of the dynamics of Dp-branes. We focus on the usual nonpolynomial Dirac-Born-Infeld action for the worldvolume swept out by the brane in its evolution in general background spacetimes. We emphasize the form of the resulting equations of motion which are quite simple and resemble Newton's second law, complemented with a conservation law for a worldvolume bicurrent

  2. Antigenic variation in vector-borne pathogens.

    OpenAIRE

    Barbour, A. G.; Restrepo, B I

    2000-01-01

    Several pathogens of humans and domestic animals depend on hematophagous arthropods to transmit them from one vertebrate reservoir host to another and maintain them in an environment. These pathogens use antigenic variation to prolong their circulation in the blood and thus increase the likelihood of transmission. By convergent evolution, bacterial and protozoal vector-borne pathogens have acquired similar genetic mechanisms for successful antigenic variation. Borrelia spp. and Anaplasma marg...

  3. Integrated epidemiology for vector-borne zoonoses

    OpenAIRE

    Wardrop, Nicola

    2015-01-01

    The development and application of interventions for the control of vector-borne zoonoses requires broad understanding of epidemiological linkages between vector, animal infection and human infection. However, there are significant gaps in our understanding of these linkages and a lack of appropriate data poses a considerable barrier to addressing this issue. A move towards strengthened surveillance of vectors and disease in both animal and human hosts, in combination with linked human-animal...

  4. Symbiotic control of mosquito borne disease

    OpenAIRE

    Ricci, Irene; Valzano, Matteo; Ulissi, Ulisse; Epis, Sara; Cappelli, Alessia; Favia, Guido

    2012-01-01

    It is well accepted that the symbiotic relationships insects have established with several microorganisms have had a key role in their evolutionary success. Bacterial symbiosis is also prevalent in insects that are efficient disease vectors, and numerous studies have sought to decrypt the basic mechanisms of the host–symbiont relationships and develop ways to control vector borne diseases. ‘Symbiotic control’, a new multifaceted approach that uses symbiotic microorganisms to control insect pe...

  5. Mosquito-borne viruses in Europe

    Czech Academy of Sciences Publication Activity Database

    Hubálek, Zdeněk

    2008-01-01

    Roč. 103, Suppl. 1 (2008), S29-S43. ISSN 0932-0113. [Vector-borne diseases: impact of climate change on vectors and rodent reservoirs. Berlin, 27.09.2007-28.09.2007] R&D Projects: GA AV ČR IAA600930611 Institutional research plan: CEZ:AV0Z60930519 Keywords : moboviruses * epidemiology Subject RIV: EE - Microbiology, Virology Impact factor: 1.473, year: 2008

  6. Geometrical dynamics of Born-Infeld objects

    OpenAIRE

    Cordero, Ruben; Molgado, Alberto; Rojas, Efrain

    2007-01-01

    We present a geometrical inspired study of the dynamics of $Dp$-branes. We focus on the usual nonpolynomial Dirac-Born-Infeld action for the worldvolume swept out by the brane in its evolution in general background spacetimes. We emphasize the form of the resulting equations of motion which are quite simple and resemble Newton's second law, complemented with a conservation law for a worldvolume bicurrent. We take a closer look at the classical Hamiltonian analysis which is supported by the AD...

  7. Promotion of Cortical Neurogenesis from the Neural Stem Cells in the Adult Mouse Subcallosal Zone.

    Science.gov (United States)

    Kim, Joo Yeon; Choi, Kyuhyun; Shaker, Mohammed R; Lee, Ju-Hyun; Lee, Boram; Lee, Eunsoo; Park, Jae-Yong; Lim, Mi-Sun; Park, Chang-Hwan; Shin, Ki Soon; Kim, Hyun; Geum, Dongho; Sun, Woong

    2016-04-01

    Neurogenesis occurs spontaneously in the subventricular zone (SVZ) of the lateral ventricle in adult rodent brain, but it has long been debated whether there is sufficient adult neurogenesis in human SVZ. Subcallosal zone (SCZ), a posterior continuum of SVZ closely associated with posterior regions of cortical white matter, has also been reported to contain adult neural stem cells (aNSCs) in both rodents and humans. However, little is known whether SCZ-derived aNSC (SCZ-aNSCs) can produce cortical neurons following brain injury. We found that SCZ-aNSCs exhibited limited neuronal differentiation potential in culture and after transplantation in mice. Neuroblasts derived from SCZ initially migrated toward injured cortex regions following brain injury, but later exhibited apoptosis. Overexpression of anti-apoptotic bcl-xL in the SCZ by retroviral infection rescued neuroblasts from cell death in the injured cortex, but neuronal maturation was still limited, resulting in atrophy. In combination with Bcl-xL, infusion of brain-derived neurotropic factor rescued atrophy, and importantly, a subset of such SCZ-aNSCs differentiated and attained morphological and physiological characteristics of mature, excitatory neurons. These results suggest that the combination of anti-apoptotic and neurotrophic factors might enable the use of aNSCs derived from the SCZ in cortical neurogenesis for neural replacement therapy. Stem Cells 2016;34:888-901. PMID:26701067

  8. Modulation of adult-born neurons in the inflamed hippocampus

    Directory of Open Access Journals (Sweden)

    Susanna Rosi

    2013-09-01

    Full Text Available Throughout life new neurons are continuously added to the hippocampal circuitry involved with spatial learning and memory. These new cells originate from neural precursors in the subgranular zone of the dentate gyrus, migrate into the granule cell layer and integrate into neural networks encoding spatial and contextual information. This process can be influenced by several environmental and endogenous factors and is modified in different animal models of neurological disorders. Neuroinflammation, as defined by the presence of activated microglia, is a common key factor to the progression of neurological disorders. Analysis of the literature shows that microglial activation impacts not only the production, but also the migration and the recruitment of new neurons. The impact of microglia on adult-born neurons appears much more multifaceted than ever envisioned before, combining both supportive and detrimental effects that are dependent upon the activation phenotype and the factors being released. The development of strategies aimed to change microglia toward states that promote functional neurogenesis could therefore offer novel therapeutic opportunities against neurological disorders associated with cognitive deficits and neuroinflammation. The present review summarizes the current knowledge on how production, distribution and recruitment of new neurons into behaviorally relevant neural networks are modified in the inflamed hippocampus.

  9. OUTCOMES OF TICK-BORNE ENCEPHALITIS IN THE TOMSK REGION

    Directory of Open Access Journals (Sweden)

    T. S. Pinegina

    2016-01-01

    Full Text Available The results of the study outcomes of tick-borne encephalitis in adults in the Tomsk Region. Patients conducted a comprehensive clinical and laboratory examination. Revealed the prevalence of autonomic disorders in individuals who have had at different periods of tick-borne encephalitis, which is regarded as the effects of tick-borne infection. Residual effects of tick-borne encephalitis occurs mainly in the form of light paresis after suffering a focal forms. Among the chronic (progredient forms of tick-borne encephalitis often formed hyperkinetic options. Most of the study revealed the presence of precipitating factors that could have an influence on the outcome. Fundamental diffe rences in all-clinical and immunological analyses at patients with various outcomes of tick-borne encephalitis it wasn't noted. KEY WORDS: tick-borne encephalitis, Tomsk Region, the outcomes.

  10. Born with Protection against Whooping Cough

    Centers for Disease Control (CDC) Podcasts

    2015-01-22

    This podcast provides information about whooping cough, a disease that can be deadly for babies, and CDC’s recommendation that all women receive the Tdap vaccine during the third trimester of every pregnancy so their babies can be born with protection from this serious disease.  Created: 1/22/2015 by National Center for Immunization and Respiratory Diseases (NCIRD), Division of Bacterial Diseases (DBD), Meningitis and Vaccine Preventable Diseases Branch (MVPDB).   Date Released: 1/22/2015.

  11. Anisotropy in Born-Infeld brane cosmology

    OpenAIRE

    Haghani, Z.; Sepangi, H. R.; shahidi, S.

    2011-01-01

    The accelerated expansion of the universe together with its present day isotropy has posed an interesting challenge to the numerous model theories presented over the years to describe them. In this paper, we address the above questions in the context of a brane-world model where the universe is filled with a Born-Infeld matter. We show that in such a model, the universe evolves from a highly anisotropic state to its present isotropic form which has entered an accelerated expanding phase.

  12. Dirac Born Infeld (DBI) Cosmic Strings

    OpenAIRE

    Babichev, Eugeny; Brax, Philippe; Caprini, Chiara; Martin, Jerome; Steer, Daniele

    2008-01-01

    Motivated by brane physics, we consider the non-linear Dirac-Born-Infeld (DBI) extension of the Abelian-Higgs model and study the corresponding cosmic string configurations. The model is defined by a potential term, assumed to be of the mexican hat form, and a DBI action for the kinetic terms. We show that it is a continuous deformation of the Abelian-Higgs model, with a single deformation parameter depending on a dimensionless combination of the scalar coupling constant, the vacuum expectati...

  13. Born expansions for charged particle scattering

    International Nuclear Information System (INIS)

    High-order terms in Born expansions of scattering amplitudes in powers of charge are frequently divergent when long-range Coulomb interactions are present asymptotically. Expansions which are free from these logarithmic divergences have been constructed recently. This paper illustrates these expansions with the simplest example, namely the non-relativistic Rutherford scattering of two charged particles. This approach represents an adequate framework for the calculation of transition amplitudes and a comprehensive starting point for the development of consistent perturbation approximations in multi-channel descriptions of strongly interacting atomic systems

  14. POLAR: a space borne GRB polarimeter

    OpenAIRE

    Lamanna, G; Fouque, N.; Hermel, R.; Vialle, J. P.; Hofer, H; Lechanoine-Leluc, C.; Orsi, S.; Pohl, M.; Rapin, D.; Gierlik, S.M.; Marcinkowski, R.; Courvoisier, T.; Haas, D.; Produit, N.; Hajdas, W.

    2008-01-01

    The direction and the level of polarization of high energy photons emitted by astrophysics sources are valuable observables for the understanding of the corresponding emission mechanisms, source geometry and strength of magnetic fields at work. POLAR is a novel compact space-borne detector conceived for a precise measurement of hard X-ray polarization and optimized for the detection of Gamma-Ray Burst (GRB) photons in the energy range 50-500 keV. In POLAR, the GRB photons undergo Compton scat...

  15. Paced-mating increases the number of adult new born cells in the internal cellular (granular layer of the accessory olfactory bulb.

    Directory of Open Access Journals (Sweden)

    Rebeca Corona

    Full Text Available The continuous production and addition of new neurons during life in the olfactory bulb is well accepted and has been extensively studied in rodents. This process could allow the animals to adapt to a changing environment. Olfactory neurogenesis begins in the subventricular zone where stem cells proliferate and give rise to young undifferentiated neuroblasts that migrate along the rostral migratory stream to the olfactory bulb (OB. Olfaction is crucial for the expression of sexual behavior in rodents. In female rats, the ability to control the rate of sexual interactions (pacing has important physiological and behavioral consequences. In the present experiment we evaluated if pacing behavior modifies the rate of new cells that reach the main and accessory olfactory bulb. The BrdU marker was injected before and after different behavioral tests which included: females placed in a mating cage (control, females allowed to pace the sexual interaction, females that mated but were not able to control the rate of the sexual interaction and females exposed to a sexually active male. Subjects were sacrificed fifteen days after the behavioral test. We observed a significant increase in the density of BrdU positive cells in the internal cellular layer of the accessory olfactory bulb when females paced the sexual interaction in comparison to the other 3 groups. No differences in the cell density in the main olfactory bulb were found. These results suggest that pacing behavior promotes an increase in density of the new cells in the accessory olfactory bulb.

  16. Novel primate miRNAs co-evolved with ancient target genes in germinal zone specific expression patterns

    Science.gov (United States)

    Arcila, Mary L; Betizeau, Marion; Cambronne, Xiaolu A; Guzman, Elmer; Doerflinger, Nathalie; Bouhallier, Frantz; Zhou, Hongjun; Wu, Bian; Rani, Neha; Bassett, Dani S; Borello, Ugo; Huissoud, Cyril; Goodman, Richard H; Dehay, Colette; Kosik, Kenneth S

    2014-01-01

    Summary Major non primate-primate differences in corticogenesis include the dimensions, precursor lineages and developmental timing of the germinal zones (GZ). microRNAs (miRNAs) of laser dissected GZ compartments and cortical plate (CP) from embryonic E80 macaque visual cortex were deep sequenced. The CP and the GZ including Ventricular Zone (VZ), outer and inner subcompartments of the Outer SubVentricular Zone (OSVZ) in area 17 displayed unique miRNA profiles. miRNAs present in primate, but absent in rodent, contributed disproportionately to the differential expression between GZ sub-regions. Prominent among the validated targets of these miRNAs were cell-cycle and neurogenesis regulators. Co-evolution between the emergent miRNAs and their targets suggested that novel miRNAs became integrated into ancient gene circuitry to exert additional control over proliferation. We conclude that multiple cell-cycle regulatory events contribute to the emergence of primate-specific cortical features, including the OSVZ, generated enlarged supragranular layers, largely responsible for the increased primate cortex computational abilities. PMID:24583023

  17. Novel primate miRNAs coevolved with ancient target genes in germinal zone-specific expression patterns.

    Science.gov (United States)

    Arcila, Mary L; Betizeau, Marion; Cambronne, Xiaolu A; Guzman, Elmer; Doerflinger, Nathalie; Bouhallier, Frantz; Zhou, Hongjun; Wu, Bian; Rani, Neha; Bassett, Danielle S; Borello, Ugo; Huissoud, Cyril; Goodman, Richard H; Dehay, Colette; Kosik, Kenneth S

    2014-03-19

    Major nonprimate-primate differences in cortico-genesis include the dimensions, precursor lineages, and developmental timing of the germinal zones (GZs). microRNAs (miRNAs) of laser-dissected GZ compartments and cortical plate (CP) from embryonic E80 macaque visual cortex were deep sequenced. The CP and the GZ including ventricular zone (VZ) and outer and inner subcompartments of the outer subventricular zone (OSVZ) in area 17 displayed unique miRNA profiles. miRNAs present in primate, but absent in rodent, contributed disproportionately to the differential expression between GZ subregions. Prominent among the validated targets of these miRNAs were cell-cycle and neurogenesis regulators. Coevolution between the emergent miRNAs and their targets suggested that novel miRNAs became integrated into ancient gene circuitry to exert additional control over proliferation. We conclude that multiple cell-cycle regulatory events contribute to the emergence of primate-specific cortical features, including the OSVZ, generated enlarged supragranular layers, largely responsible for the increased primate cortex computational abilities. PMID:24583023

  18. Dynamical theory of stratified Fresnel linear zone plates

    International Nuclear Information System (INIS)

    A dynamical theory is given for calculating the performances of stratified Fresnel linear zone plates (SFLZP's). The Born expansion extended to the Fresnel diffraction is used to prove a fundamental theorem giving the diffraction efficiency and the diffraction pattern of transmission or reflection SFLZP's. The method is valuable as long as the wavelength is smaller than the characteristic parameter of the zone plate. It allows us to evaluate the performances of reflection multilayer SFLZPs, i.e., the so-called Bragg-Fresnel optics recently developed for x-ray optics. 17 refs., 8 figs

  19. Health Beliefs of College Students Born in the United States, China, and India

    Science.gov (United States)

    Rothstein, William G.; Rajapaksa, Sushama

    2003-01-01

    The authors surveyed 243 urban public university students who were born in the United States, China, and India to compare the health beliefs of the China-born, India-born, and US-born students. Although the China- and India-born students shared beliefs in many preventive and therapeutic practices of Western medicine with the US-born students, they…

  20. Second order Born calculation for charge transfer

    International Nuclear Information System (INIS)

    Charge transfer cross sections, from the ground state of the target to the ground state of the projectile, have been computed in a second order Born approximation for protons incident upon hydrogen at energies of 1, 10, and 50 MeV. The exact second order matrix element is evaluated numerically, and the results are compared to a standard peaking approximation (SP), as well as to a new peaking approximation (LP) developed herein. At 50 MeV two distinct second order effects are evident in the differential cross section. For very small (center of mass) scattering angles (THETA approx. = .0320) the second order cross section is smaller than the first order cross section, while at larger angles (THETA approx. = .0540) a second Born peak occurs. This peak can be kinematically associated with a classical two step process which gives rise to the well known dominating v-11 asymptotic velocity dependence of the total cross section. The reduction of the differential cross section at smaller angles serves to decrease the total cross section, as is predicted by the asymptotic expression. At 10 MeV second order effects become less important, and at 1 MeV the kinematic peak has all but disappeared, while the second order cross section has here become larger than the first order cross section. At intermediate energies experimental results indicate that the first order cross section used here is itself too large

  1. Biosensors: tool for food borne pathogen detection

    Directory of Open Access Journals (Sweden)

    Heena Sharma

    2013-12-01

    Full Text Available A paramount and alluring sphere of research, now-a-days, is food analysis, because of the breakneck augmentation of food enterprise and highly hightened maneuverability of today's populations. The management of food quality is very indispensable both for consumer safeguard as well as the food corporations. The biosensors' application in the field of food analysis is quite propitious for the revealing of food borne pathogens. Biosensor, an analytical device, transforms a biological response into an electrical signal. Bioreceptors and transducers are the two main components of a biosensor. Bioreceptor or biorecognition element is the one which leads to the recognition of target analyte and a transducer, for the conversion of recognized event into a measurable electrical signal. The development of biosensors improved the sensitivity and selectivity of detection techniques for food borne pathogens and is rapid, reliable, effective and highly suitable when used in in situ analysis. Since the security in the food supply becomes crucial because of increased perception among consumers and vying nature of food industries, the necessity for expeditious, low volume and sensitive biosensor devices has productively increased. Nevertheless, till date, a very few biosensor systems are available commercially such as Biacore, SpreetaTM, Reichert SR 7000, Analyte 2000, RAPTOR etc. Since, there is ever growing concern regarding safe food and water supply, it is very obvious that the demand for rapid detecting biosensors will also be increasing at par.

  2. CMB-lensing beyond the Born approximation

    CERN Document Server

    Marozzi, Giovanni; Di Dio, Enea; Durrer, Ruth

    2016-01-01

    We investigate the weak lensing corrections to the cosmic microwave background temperature anisotropies considering effects beyond the Born approximation. To this aim, we use the small deflection angle approximation, to connect the lensed and unlensed power spectra, via expressions for the deflection angles up to third order in the gravitational potential. While the small deflection angle approximation has the drawback to be reliable only for multipoles $\\ell\\lesssim 2500$, it allows us to consistently take into account the non-Gaussian nature of cosmological perturbation theory beyond the linear level. The contribution to the lensed temperature power spectrum coming from the non-Gaussian nature of the deflection angle at higher order is a new effect which has not been taken into account in the literature so far. It turns out to be the leading contribution among the post-Born lensing corrections. On the other hand, the effect is smaller than corrections coming from non-linearities in the matter power spectrum...

  3. Extended Born-Infeld dynamics and cosmology

    International Nuclear Information System (INIS)

    We introduce an extension of the Born-Infeld action for a scalar field and show that it can act as unifying dark matter, providing an explanation for both structure formation and the accelerated expansion of the universe. We investigate the cosmological dynamics of this theory in a particular case, referred to as the 'Milne-Born-Infeld' (MBI) Lagrangian. We show that this model, whose equation of state has effectively a single free parameter, is consistent with recent type Ia supernovae data, providing a fit as good as for the ΛCDM model with the same number of degrees of freedom. Furthermore, this parameter is tightly constrained by current data, making the model easily testable with other observables. Contrary to previous candidates for unifying dark matter, the sound velocity of the MBI model is vanishing both close to the dark-matter state as well as near the cosmological constant state. This could avoid the problems on the matter power spectrum that were present in previous adiabatic dark-matter/dark-energy unification models. We also present a short discussion on the causal propagation in nonlinear scalar field theories such as the one proposed here

  4. The Born rule fails in cosmology

    International Nuclear Information System (INIS)

    The Born rule may be stated mathematically as the rule that probabilities in quantum theory are expectation values of a complete orthogonal set of projection operators. This rule works for single laboratory settings in which the observer can distinguish all the different possible outcomes corresponding to the projection operators. However, theories of inflation suggest that the universe may be so large that any laboratory, no matter how precisely it is defined by its internal state, may exist in a large number of very distantly separated copies throughout the vast universe. In this case, no observer within the universe can distinguish all possible outcomes for all copies of the laboratory. Then normalized probabilities for the local outcomes that can be locally distinguished cannot be given by the expectation values of any projection operators. Thus the Born rule fails and must be replaced by another rule for observational probabilities in cosmology. The freedom of what this new rule is to be is the measure problem in cosmology. A particular volume-averaged form is proposed

  5. Neurodevelopmental outcomes of infants born prematurely.

    Science.gov (United States)

    Aylward, Glen P

    2014-01-01

    Long-term follow-up of infants born prematurely is necessary to determine neurodevelopmental outcomes, particularly with the expansion of interest from major disabilities to high prevalence/low severity dysfunctions. Models of pathogenesis include changes due to developmental disruptions and to injury, the magnitude and type of change influenced by the infant's age, and central nervous system recovery and reorganization. Alterations in neurogenesis, migration, myelination, cell death, and synaptogenesis occur even in the absence of insult. Despite increased knowledge regarding these processes, the functional significance of brain abnormalities is unclear. Because of methodologic problems in follow-up studies, it is difficult to characterize outcome definitively. Nonetheless, an acceptable degree of agreement across studies is found with regard to specific neurodevelopmental outcomes: motor/neurologic function, visuomotor integrative skills, IQ, academic achievement, language, executive function, and attention-deficit hyperactivity disorder/behavioral issues. In general, children born prematurely have more problems in these areas than do their normal birth weight counterparts. Suggestions for improved analyses and clarification of outcomes include use of cluster analysis, structural equation modeling, growth curve analysis, developmental epidemiologic approaches, and better control of background variables using risk indexes and factor scores. Better assessment techniques measuring functions documented to be at higher risk of problems are discussed. PMID:25007063

  6. Extended Born-Infeld Dynamics and Cosmology

    CERN Document Server

    Novello, M; Werneck, L S; Romero, C A

    2005-01-01

    We introduce an extension of the Born-Infeld action for a scalar field and show that it can act as unifying-dark-matter, providing an explanation for both structure formation and the accelerated expansion of the universe. We investigate the cosmological dynamics of this theory in a particular case, referred as the "Milne-Born-Infeld" (MBI) Lagrangian. We show that this model, whose equation of state has effectively a single free parameter, is consistent with recent type Ia supernovae data, providing a fit as good as for the $\\Lambda$CDM model with the same number of degrees of freedom. Furthermore, this parameter is tightly constrained by current data, making the model easily testable with other observables. Contrary to previous candidates for unifying-dark-matter, the sound velocity of the MBI model is vanishing both close to the dark matter state as well as near the cosmological constant state. This could avoid the problems on the matter power spectrum that were present in previous adiabatic dark-matter/dar...

  7. Methods for case studies of waste-borne polluted groundwater zones

    International Nuclear Information System (INIS)

    The processes of deterioration and self-purification in the ground can be evaluated by comparing the chemical, isotope-chemical, microbiological and hygienic properties of the groundwater upstream and downstream of the pollution source. During the investigations at three waste sites the necessary information was collected using the following procedures: (a) construction of a net of observation wells; (b) determination of groundwater direction and velocity using hydrologic and radiohydrometric methods (ksub(f)-determination by pumping-tests and single-well methods, construction of groundwater contours); (c) chemical and physical measurements of water samples from observation wells; (d) microbiological determinations in water and sediments of wells, ponds, creeks, or even of aquifer material itself; (e) evaluation of the data using feasible statistical and graphical tools (electronic data processing) and (f) study of the distribution of stable isotopes in leachates and groundwaters. (author)

  8. Cardiometabolic Risk Factors in Young Adults Who Were Born Preterm

    Science.gov (United States)

    Sipola-Leppänen, Marika; Vääräsmäki, Marja; Tikanmäki, Marjaana; Matinolli, Hanna-Maria; Miettola, Satu; Hovi, Petteri; Wehkalampi, Karoliina; Ruokonen, Aimo; Sundvall, Jouko; Pouta, Anneli; Eriksson, Johan G.; Järvelin, Marjo-Riitta; Kajantie, Eero

    2015-01-01

    Adults who were born preterm with a very low birth weight have higher blood pressure and impaired glucose regulation later in life compared with those born at term. We investigated cardiometabolic risk factors in young adults who were born at any degree of prematurity in the Preterm Birth and Early Life Programming of Adult Health and Disease (ESTER) Study, a population-based cohort study of individuals born in 1985–1989 in Northern Finland. In 2009–2011, 3 groups underwent clinical examination: 134 participants born at less than 34 gestational weeks (early preterm), 242 born at 34–36 weeks (late preterm), and 344 born at 37 weeks or later (controls). Compared with controls, adults who were born preterm had higher body fat percentages (after adjustment for sex, age, and cohort (1985–1986 or 1987–1989), for those born early preterm, difference = 6.2%, 95% confidence interval (CI): 0.4, 13.2; for those born late preterm, difference = 8.0%, 95% CI: 2.4, 13.8), waist circumferences, blood pressure (for those born early preterm, difference = 3.0 mm Hg, 95% CI: 0.9, 5.1; for those born late preterm, difference = 1.7, 95% CI: −0.1, 3.4), plasma uric acid levels (for those born early preterm, difference = 20.1%, 95% CI: 7.9, 32.3; for those born late preterm, difference = 20.2%, 95% CI: 10.7, 30.5), alanine aminotransferase levels, and aspartate transaminase levels. They were also more likely to have metabolic syndrome (for those born early preterm, odds ratio = 3.7, 95% CI: 1.6, 8.2; for those born late preterm, odds ratio = 2.5, 95% CI: 1.2, 5.3). Elevated levels of conventional and emerging risk factors suggest a higher risk of cardiometabolic disease later in life. These risk factors are also present in the large group of adults born late preterm. PMID:25947956

  9. Canine vector-borne diseases in Brazil

    Directory of Open Access Journals (Sweden)

    Dantas-Torres Filipe

    2008-08-01

    Full Text Available Abstract Canine vector-borne diseases (CVBDs are highly prevalent in Brazil and represent a challenge to veterinarians and public health workers, since some diseases are of great zoonotic potential. Dogs are affected by many protozoa (e.g., Babesia vogeli, Leishmania infantum, and Trypanosoma cruzi, bacteria (e.g., Anaplasma platys and Ehrlichia canis, and helminths (e.g., Dirofilaria immitis and Dipylidium caninum that are transmitted by a diverse range of arthropod vectors, including ticks, fleas, lice, triatomines, mosquitoes, tabanids, and phlebotomine sand flies. This article focuses on several aspects (etiology, transmission, distribution, prevalence, risk factors, diagnosis, control, prevention, and public health significance of CVBDs in Brazil and discusses research gaps to be addressed in future studies.

  10. Human sparganosis, a neglected food borne zoonosis.

    Science.gov (United States)

    Liu, Quan; Li, Ming-Wei; Wang, Ze-Dong; Zhao, Guang-Hui; Zhu, Xing-Quan

    2015-10-01

    Human sparganosis is a food borne zoonosis caused by the plerocercoid larvae (spargana) of various diphyllobothroid tapeworms of the genus Spirometra. Human infections are acquired by ingesting the raw or undercooked meat of snakes or frogs, drinking untreated water, or using raw flesh in traditional poultices. More than 1600 cases of sparganosis have been documented worldwide, mostly in east and southeast Asia. Sporadic cases have been reported in South America, Europe, and Africa, and several cases have been described in travellers returning from endemic regions. Epidemiological data suggest that the increased effect of sparganosis on human health is because of greater consumption of raw meat of freshwater frogs and snakes. This Review provides information about the Spirometra parasites and their lifecycles, summarises clinical features, diagnosis, and treatment of human sparganosis, and describes geographical distribution and infection characteristics of Spirometra parasites in host animals. PMID:26364132

  11. Generalized Fibonacci zone plates

    CERN Document Server

    Ke, Jie; Zhu, Jianqiang

    2015-01-01

    We propose a family of zone plates which are produced by the generalized Fibonacci sequences and their axial focusing properties are analyzed in detail. Compared with traditional Fresnel zone plates, the generalized Fibonacci zone plates present two axial foci with equal intensity. Besides, we propose an approach to adjust the axial locations of the two foci by means of different optical path difference, and further give the deterministic ratio of the two focal distances which attributes to their own generalized Fibonacci sequences. The generalized Fibonacci zone plates may allow for new applications in micro and nanophotonics.

  12. Born Too Soon: Accelerating actions for prevention and care of 15 million newborns born too soon

    OpenAIRE

    Lawn, JE; Kinney, MV; Belizan, JM; Mason, E.; McDougall, L; Larson, J; Lackritz, E; Friberg, IK; Howson, CP; the Born Too Soon Preterm Birth Action Group (see acknowledgemen

    2013-01-01

    DECLARATION This article is part of a supplement jointly funded by Save the Children's Saving Newborn Lives programme through a grant from The Bill & Melinda Gates Foundation and March of Dimes Foundation and published in collaboration with the Partnership for Maternal, Newborn and Child Health and the World Health Organization (WHO). The original article was published in PDF format in the WHO Report "Born Too Soon: the global action report on preterm birth" (ISBN 978 92 4 150343 30), which i...

  13. Fault zone hydrogeology

    Science.gov (United States)

    Bense, V. F.; Gleeson, T.; Loveless, S. E.; Bour, O.; Scibek, J.

    2013-12-01

    Deformation along faults in the shallow crust (evaluation of the impact of faults to fluid flow patterns remains a challenge and requires a multidisciplinary research effort of structural geologists and hydrogeologists. However, we find that these disciplines often use different methods with little interaction between them. In this review, we document the current multi-disciplinary understanding of fault zone hydrogeology. We discuss surface- and subsurface observations from diverse rock types from unlithified and lithified clastic sediments through to carbonate, crystalline, and volcanic rocks. For each rock type, we evaluate geological deformation mechanisms, hydrogeologic observations and conceptual models of fault zone hydrogeology. Outcrop observations indicate that fault zones commonly have a permeability structure suggesting they should act as complex conduit-barrier systems in which along-fault flow is encouraged and across-fault flow is impeded. Hydrogeological observations of fault zones reported in the literature show a broad qualitative agreement with outcrop-based conceptual models of fault zone hydrogeology. Nevertheless, the specific impact of a particular fault permeability structure on fault zone hydrogeology can only be assessed when the hydrogeological context of the fault zone is considered and not from outcrop observations alone. To gain a more integrated, comprehensive understanding of fault zone hydrogeology, we foresee numerous synergistic opportunities and challenges for the discipline of structural geology and hydrogeology to co-evolve and address remaining challenges by co-locating study areas, sharing approaches and fusing data, developing conceptual models from hydrogeologic data, numerical modeling, and training interdisciplinary scientists.

  14. Rickettsia slovaca and R. raoultii in Tick-borne Rickettsioses

    OpenAIRE

    Parola, Philippe; Rovery, Clarisse; Rolain, Jean Marc; Brouqui, Philippe; Davoust, Bernard; Raoult, Didier

    2009-01-01

    Tick-borne lymphadenopathy (TIBOLA), also called Dermacentor-borne necrosis erythema and lymphadenopathy (DEBONEL), is defined as the association of a tick bite, an inoculation eschar on the scalp, and cervical adenopathies. We identified the etiologic agent for 65% of 86 patients with TIBOLA/DEBONEL as either Rickettsia slovaca (49/86, 57%) or R. raoultii (7/86, 8%).

  15. Non-linear electrostatic waves in Born-Infeld plasmas

    International Nuclear Information System (INIS)

    Motivated by the suggestion that Born-Infeld plasmas could have significance for electron acceleration in neutron star crusts, we obtain an upper bound on the amplitude of electrostatic waves propagating parallel to a longitudinal magnetic field in a Born-Infeld plasma.

  16. Non-linear electrostatic waves in Born-Infeld plasmas

    OpenAIRE

    Burton, D. A.; Wen, H

    2010-01-01

    Motivated by the suggestion that Born-Infeld plasmas could have significance for electron acceleration in neutron star crusts, we obtain an upper bound on the amplitude of electrostatic waves propagating parallel to a longitudinal magnetic field in a Born-Infeld plasma.

  17. Air-borne geophysical prospecting using Helicopter

    International Nuclear Information System (INIS)

    The air-borne geophysical prospecting can investigate geological properties widely and quickly. In this investigation, we applied 3-types of geophysical prospecting, those were Electro-magnetic, Magnetic, and Radiometric method. We can measure apparent resistivity of ground on Electro-magnetic method, radioactivity on Radiometric method, and magnetization on Magnetic method. We can measure also resistivity distribution in the depth direction by measuring electro magnetic response to various frequencies. Conducting measurement, analysis and interpretation of above-mentioned 3-geophysical properties, we solved the geological structure from the distribution of geophysical properties in this area. We also tried to study and discuss comparison and correspondence with the present geological map. The air-borne Electro-magnetic method showed that the regions distributed with Sarabetsu Formation and Isachi Formation, which mainly consists of sandstone and conglomerate, have high apparent resistivity about 30-500 Ω·m. The regions distributed with Kowama Formation, Wakkanai Formation and Mashihoro Formation (Upper Mudstone Layer), which mainly consists of mudrock, have low resistivity 1-10 Ω·m in the depth over than dozens of meters, though some area dozens of meter below the surface have high resistivity about 50-200 Ω·m. Magnetic method showed that magnetization tends to decrease from southwest to northeast and this result corresponded with previous large scale magnetic intensity map (Geological Survey of Japan, 1992). High magnetic anomaly area, which spread from north-northwest to south-southeast, is found on a boundary between Sarabetsu and Isachi formation. Mashihoro formation, which is located east side of Nukanan fault, has also high magnetic anomaly area. Radiometric method showed that high radioactivity areas are distributed in alluvial depressions along Tenshio river and small river in the hill, while low radioactivity area are distributed in Tertiary

  18. Exact second Born electron capture for p+He

    International Nuclear Information System (INIS)

    Formulation and exact numerical calculation of differential and total 1s-1s electron-capture cross sections with the use of the second Born approximation with the free-wave Green's function are presented. At energies above 15 MeV there appears in the differential cross section a peak characteristic of a second Born or two-step process. For total cross sections, our calculations show that below 7 MeV the second-order cross section is larger than the first-order cross section, indicating a breakdown of second-order Born approximation with the free-wave Green's function. Results using the peaking approximation of Drisko converge to our exact second Born results only at energies well above 30 MeV. According to our exact second-Born calculations, observation of the angular distribution above 15 MeV should reveal structure related to at least one two-step mechanism for electron capture

  19. Atopic diseases in twins born after assisted reproduction

    DEFF Research Database (Denmark)

    Jäderberg, Ida; Thomsen, Simon F; Kyvik, Kirsten Ohm; Skytthe, Axel; Backer, Vibeke

    2012-01-01

    Jäderberg I, Thomsen SF, Kyvik KO, Skytthe A, Backer V. Atopic diseases in twins born after assisted reproduction. Paediatric and Perinatal Epidemiology 2012; 26: 140-145. We examined the risk of atopic diseases in twins born after assisted reproduction. Data on atopic diseases and assisted...... reproduction in 9694 twin pairs, 3-20 years of age, from the Danish Twin Registry were collected via multidisciplinary questionnaires. The risk of atopic diseases in twins born after assisted reproduction was compared with the risk in twins born after spontaneous conception using logistic regression and...... variance components analysis. Children born after assisted reproduction did not have a different risk of atopic outcomes (adjusted odds ratios [95% confidence intervals] for asthma: 0.95 [0.85, 1.07], P = 0.403; hay fever: 1.01 [0.86, 1.18], P = 0.918; and atopic dermatitis: 1.02 [0.81, 1.11], P = 0...

  20. The Lived Experiences of Canadian-Born and Foreign-Born Chinese Canadian Post-Secondary Students in Northern Ontario

    Science.gov (United States)

    Wang, Fei

    2016-01-01

    This phenomenological study provided an in-depth description of the internal meaning of the lived experiences of Canadian-born and foreign-born Chinese students in Canada and uncovered the differences in their social experiences. The study used semi-structured interviews to allow the participants to express their views on their lives in Northern…

  1. Young Adult Outcomes of Children Born to Teen Mothers: Effects of Being Born during Their Teen or Later Years

    Science.gov (United States)

    Lipman, Ellen L.; Georgiades, Katholiki; Boyle, Michael H.

    2011-01-01

    Objective: Children of teen mothers exhibit adverse outcomes through adolescence. It is unclear whether these adverse outcomes extend to adulthood and apply to all of her children, or only those born when she was a teen. We examine the associations between young adult functioning and being born to a teen mother aged less than or equal to 20 years…

  2. New neurons in the adult brain: The role of sleep and consequences of sleep loss

    OpenAIRE

    Meerlo, Peter; Mistlberger, Ralph E.; Jacobs, Barry L.; Heller, H Craig; McGinty, Dennis

    2008-01-01

    Research over the last few decades has firmly established that new neurons are generated in selected areas of the adult mammalian brain, particularly the dentate gyrus of the hippocampal formation and the subventricular zone of the lateral ventricles. The function of adult-born neurons is still a matter of debate. In the case of the hippocampus, integration of new cells in to the existing neuronal circuitry may be involved in memory processes and the regulation of emotionality. In recent year...

  3. Birthdate of parvalbumin-neurons in the Parvafox-nucleus of the lateral hypothalamus

    OpenAIRE

    Bilella, Alessandro; Alvarez-Bolado, Gonzalo; Celio, Marco R.

    2016-01-01

    The Parvafox-nucleus in the lateral hypothalamus is characterized by the presence of two distinct neural populations, the Parvalbumin (Parv) and the Foxb1-expressing ones. Foxb1-neurons are born at day 10 in the subventricular zone of the mouse mammillary region. It would be interesting to know if the subpopulation of Parv- neurons develop independently at different times and then meet the Foxb1- expressing neurons in the lateral hypothalamus, their final settling place. The aim of this ...

  4. Blood-Borne Infections in Tattooed People

    Directory of Open Access Journals (Sweden)

    Hashemi-Shahri

    2016-04-01

    Full Text Available Background Tattoos are associated with blood-borne infections that result from viruses such as the hepatitis B virus (HBV, the hepatitis C virus (HCV, and the human immunodeficiency virus (HIV. This association is equally evident among people without major risk factors and among those with major risk factors like injected drug users (IDUs. Objectives In this study we evaluated all tattooed patients admitted to our hospital (the Boo-Ali hospital in southeastern Iran between February 2006 to January 2015. Patients and Methods The patients enrolled in our study were admitted to infectious disease wards for different illnesses (e. g., Pneumonia, Sepsis, Tuberculosis, etc..We only studied the patients who agreed to be included in our study. When we found at least one tattooed area, regardless of its size, we took a blood sample and tested it for the presence of HIV, HBV, and HCV. Results Among the 63 patients with tattoos (21% female, 79% male, age range:16 to 79-years-old, four patients (6.3% tested positive for HBsAg and PCR-HBV, seven patients (11% tested positive for HCV, and five (7.9% tested positive for HIV. The last group consisted in IDUs and all five had several tattooed areas on their bodies. Conclusions Upon our results, tattooed people even with a small size of tattoo on the body are more at risk for HCV, HBV, and HIV infection.

  5. BAT-BORNE RABIES IN LATIN AMERICA

    Directory of Open Access Journals (Sweden)

    Luis E. Escobar

    2015-02-01

    Full Text Available The situation of rabies in America is complex: rabies in dogs has decreased dramatically, but bats are increasingly recognized as natural reservoirs of other rabies variants. Here, bat species known to be rabies-positive with different antigenic variants, are summarized in relation to bat conservation status across Latin America. Rabies virus is widespread in Latin American bat species, 22.5%75 of bat species have been confirmed as rabies-positive. Most bat species found rabies positive are classified by the International Union for Conservation of Nature as “Least Concern”. According to diet type, insectivorous bats had the most species known as rabies reservoirs, while in proportion hematophagous bats were the most important. Research at coarse spatial scales must strive to understand rabies ecology; basic information on distribution and population dynamics of many Latin American and Caribbean bat species is needed; and detailed information on effects of landscape change in driving bat-borne rabies outbreaks remains unassessed. Finally, integrated approaches including public health, ecology, and conservation biology are needed to understand and prevent emergent diseases in bats.

  6. Born Pupils? Natural Pedagogy and Cultural Pedagogy.

    Science.gov (United States)

    Heyes, Cecilia

    2016-03-01

    The theory of natural pedagogy is an important focus of research on the evolution and development of cultural learning. It proposes that we are born pupils; that human children genetically inherit a package of psychological adaptations that make them receptive to teaching. In this article, I first examine the components of the package-eye contact, contingencies, infant-directed speech, gaze cuing, and rational imitation-asking in each case whether current evidence indicates that the component is a reliable feature of infant behavior and a genetic adaptation for teaching. I then discuss three fundamental insights embodied in the theory: Imitation is not enough for cumulative cultural inheritance, the extra comes from blind trust, and tweaking is a powerful source of cognitive change. Combining the results of the empirical review with these insights, I argue that human receptivity to teaching is founded on nonspecific genetic adaptations for social bonding and social learning and acquires its species- and functionally specific features through the operation of domain-general processes of learning in sociocultural contexts. We engage, not in natural pedagogy, but in cultural pedagogy. PMID:26993279

  7. Bat-borne rabies in Latin America.

    Science.gov (United States)

    Escobar, Luis E; Peterson, A Townsend; Favi, Myriam; Yung, Verónica; Medina-Vogel, Gonzalo

    2015-01-01

    The situation of rabies in America is complex: rabies in dogs has decreased dramatically, but bats are increasingly recognized as natural reservoirs of other rabies variants. Here, bat species known to be rabies-positive with different antigenic variants, are summarized in relation to bat conservation status across Latin America. Rabies virus is widespread in Latin American bat species, 22.5%75 of bat species have been confirmed as rabies-positive. Most bat species found rabies positive are classified by the International Union for Conservation of Nature as "Least Concern". According to diet type, insectivorous bats had the most species known as rabies reservoirs, while in proportion hematophagous bats were the most important. Research at coarse spatial scales must strive to understand rabies ecology; basic information on distribution and population dynamics of many Latin American and Caribbean bat species is needed; and detailed information on effects of landscape change in driving bat-borne rabies outbreaks remains unassessed. Finally, integrated approaches including public health, ecology, and conservation biology are needed to understand and prevent emergent diseases in bats. PMID:25651328

  8. Paratransgenic Control of Vector Borne Diseases

    Directory of Open Access Journals (Sweden)

    Ivy Hurwitz, Annabeth Fieck, Amber Read, Heidi Hillesland, Nichole Klein, Angray Kang, Ravi Durvasula

    2011-01-01

    Full Text Available Conventional methodologies to control vector borne diseases with chemical pesticides are often associated with environmental toxicity, adverse effects on human health and the emergence of insect resistance. In the paratransgenic strategy, symbiotic or commensal microbes of host insects are transformed to express gene products that interfere with pathogen transmission. These genetically altered microbes are re-introduced back to the insect where expression of the engineered molecules decreases the host's ability to transmit the pathogen. We have successfully utilized this strategy to reduce carriage rates of Trypanosoma cruzi, the causative agent of Chagas disease, in the triatomine bug, Rhodnius prolixus, and are currently developing this methodology to control the transmission of Leishmania donovani by the sand fly Phlebotomus argentipes. Several effector molecules, including antimicrobial peptides and highly specific single chain antibodies, are currently being explored for their anti-parasite activities in these two systems. In preparation for eventual field use, we are actively engaged in risk assessment studies addressing the issue of horizontal gene transfer from the modified bacteria to environmental microbes.

  9. Entanglement in the Born-Oppenheimer Approximation

    CERN Document Server

    Izmaylov, Artur F

    2016-01-01

    The role of electron-nuclear entanglement on the validity of the Born-Oppenheimer (BO) approximation is investigated. While nonadiabatic couplings generally lead to entanglement and to a failure of the BO approximation, surprisingly the degree of electron-nuclear entanglement is found to be uncorrelated with the degree of validity of the BO approximation. This is because while the degree of entanglement of BO states is determined by their deviation from the corresponding states in the crude BO approximation, the accuracy of the BO approximation is dictated, instead, by the deviation of the BO states from the exact electron-nuclear states. In fact, in the context of a minimal avoided crossing model, extreme cases are identified where an adequate BO state is seen to be maximally entangled, and where the BO approximation fails but the associated BO state remains approximately unentangled. Further, the BO states are found to not preserve the entanglement properties of the exact electron-nuclear eigenstates, and t...

  10. The neonate was born with holoprosencephaly

    Directory of Open Access Journals (Sweden)

    reza saeidi

    2014-12-01

    Full Text Available holoprosencephaly is a rare congenital brain malformation resulting from failure of diverticulation and cleavage of primitive prosencephalon which occurs at 4 - 8th week of gestation and is usually associated with multiple midline facial anomalies. it is the most common forebrain developmental anomaly in humans with prevalence of 1/16,000 in live borns, an incidence as high as 1:250 in conceptuses, and a worldwide distribution6. The etiology of HPE is very heterogeneous. First, this pathology can be caused by environmental or metabolic factors. The only formally recognized environmental factors are insulin-dependent diabetes mellitus (1% risk of HPE and maternal alcoholism with a risk that cumulates with smoking . Clinical expression is variable, extending in unbroken sequence from a small brain with a single cerebral ventricle and cyclopia to clinically unaffected carriers in familial holoprosencephaly. Here. we report a boy 39 weeks neonatal case of holoprosencephaly with Antenatal ultrasonographic diagnosis, with microcephaly, hypotelorism, flat nose, a single nostril, a midline cleft lip and palate microcephaly.

  11. Quality of Cancer Care Among Foreign-Born and US-Born Patients With Lung or Colorectal Cancer

    DEFF Research Database (Denmark)

    Nielsen, Signe Smith; He, Yulei; Ayanian, John Z.;

    2010-01-01

      BACKGROUND: Disparities in care have been documented for foreign-born cancer patients in the United States. However, few data are available regarding patients with lung and colorectal cancer. In the current study, the authors assessed whether patient-reported quality and receipt of recommended...... care differed between US-born and foreign-born cancer patients. METHODS: The authors collected surveys and medical records for a population-based cohort including white, Hispanic, and Asian adults (2205 US-born and 890 foreign-born individuals) with lung or colorectal cancer diagnosed in California...... from 2003 through 2005. Logistic regression was used to assess the association between nativity and patient-reported quality of care and receipt of recommended treatments (adjuvant chemotherapy for stage III colon cancer, adjuvant chemotherapy and radiotherapy for stage II/III rectal cancer, and...

  12. SIGNR1-Negative Red Pulp Macrophages Protect against Acute Streptococcal Sepsis after Leishmania donovani-Induced Loss of Marginal Zone Macrophages

    NARCIS (Netherlands)

    Kirby, A.C.; Beattie, L.; Maroof, A.; Rooijen, van N.; Kaye, P.M.

    2009-01-01

    Marginal zone macrophages in the murine spleen play an important role in the capture of blood-borne pathogens and are viewed as an essential component of host defense against the development of pneumococcal sepsis. However, we and others have previously described the loss of marginal zone macrophage

  13. Phase zone photon sieve

    Institute of Scientific and Technical Information of China (English)

    Jia Jia; Xie Chang-Qing

    2009-01-01

    A novel diffractive optical element, named phase zone photon sieve (PZPS), is presented. There are three kinds of phase plates in PZPSs: PZPS1, PZPS2, and PZPS3. Each of the PZPSs has its own structure and is made on quartz substrate by etching. The three PZPSs have stronger diffraction peak intensity than a photon sieve (PS) when the margin pinhole and zone line width are kept the same. The PZPS3 can produce a smaller central diffractive spot than the ordinary PS with the same number of zones on the Fresnel zone plate. We have given the design method for and the simulation of PZPS and PS. PZPS has potential applications in optical maskless lithography.

  14. BLM Solar Energy Zones

    Data.gov (United States)

    Bureau of Land Management, Department of the Interior — Priority development areas for utility-scale solar energy facilities as identified in the Solar PEIS Record of Decision. An additional Solar Energy Zone identified...

  15. Phase zone photon sieve

    International Nuclear Information System (INIS)

    A novel diffractive optical element, named phase zone photon sieve (PZPS), is presented. There are three kinds of phase plates in PZPSs: PZPS1, PZPS2, and PZPS3. Each of the PZPSs has its own structure and is made on quartz substrate by etching. The three PZPSs have stronger diffraction peak intensity than a photon sieve (PS) when the margin pinhole and zone line width are kept the same. The PZPS3 can produce a smaller central diffractive spot than the ordinary PS with the same number of zones on the Fresnel zone plate. We have given the design method for and the simulation of PZPS and PS. PZPS has potential applications in optical maskless lithography. (classical areas of phenomenology)

  16. : Seizure onset zone imaging

    OpenAIRE

    David, Olivier; Blauwblomme, Thomas; Job, Anne-Sophie; Chabardès, Stéphan; Hoffmann, Dominique,; Minotti, Lorella; Kahane, Philippe

    2011-01-01

    International audience Stereo-electroencephalography is used to localize the seizure onset zone and connected neuronal networks in surgical candidates suffering from intractable focal epilepsy. The concept of an epileptogenicity index has been proposed recently to represent the likelihood of various regions being part of the seizure onset zone. It quantifies low-voltage fast activity, the electrophysiological signature of seizure onset usually assessed visually by neurologists. Here, we re...

  17. Planetary Science with Balloon-Borne Telescopes

    Science.gov (United States)

    Kremic, Tibor; Cheng, Andy; Hibbitts, Karl; Young, Eliot

    2015-01-01

    of the residual motion from the gondola that was not addressed by the gondolas coarse pointing systems. The mission met its primary science and engineering objectives. The results of the BOPPS mission will feed into the body of science knowledge but also feed into future planning for more science from balloon-borne platforms. A notional platform called Gondola for High-Altitude Planetary Science (GHAPS) has been explored and this concept platform can address a number of important decadal questions. This paper provides a summary of the assessment of potential balloon borne observations for planetary science purposes including where potential science contributions can be expected, the necessary performance characteristics of the platform, and other features required or desired. The BOPPS mission is summarized including descriptions of the main elements and key science and engineering results. The paper then briefly describes GHAPS, and the salient features that can make it a valuable tool for future planetary observations.

  18. Flux compactifications in Einstein-Born-Infeld theories

    CERN Document Server

    Ramadhan, Handhika S; Iqbal, Muhammad

    2015-01-01

    We investigate the flux compactification mechanism in simple toy models of Einstein-Born-Infeld theories. These are the direct generalizations of the Einstein-Maxwell flux compactifications that recently gained fame as a toy model for tunneling in the landscape. Our investigation reveals that the Born-Infeld form does not significantly modify the qualitative result of the Einstein-Maxwell theory. for the case of Einstein-Higgs theory, however, we found that the effect of Born-Infeld nonlinearity is to render all q>1 extradimensional compactification unstable against semiclassical tunneling to nothing.

  19. Flux compactifications in Einstein-Born-Infeld theories

    Science.gov (United States)

    Ramadhan, Handhika S.; Cahyo, Brian A.; Iqbal, Muhammad

    2015-07-01

    We investigate the flux compactification mechanism in simple toy models of Einstein-Born-Infeld theories. These are the direct generalizations of the Einstein-Maxwell flux compactifications that recently gained fame as a toy model for tunneling in the landscape. Our investigation reveals that the Born-Infeld form does not significantly modify the qualitative result of the Einstein-Maxwell theory. For the case of Einstein-Higgs theory, however, we found that the effect of Born-Infeld nonlinearity is to render all q >1 extradimensional compactification unstable against semiclassical tunneling to nothing.

  20. Born-Infeld electrostatics in the complex plane

    CERN Document Server

    Ferraro, Rafael

    2010-01-01

    The complex method to obtain 2-dimensional Born-Infeld electrostatic solutions is presented in a renewed form. The solutions are generated by a holomorphic seed that makes contact with the Coulombian complex potential. The procedure is exemplified by solving the Born-Infeld multipolar configurations. Besides, it is shown that the attractive force between two equal but opposite charges is lower than its Coulombian partner; it decreases up to vanish when the charges approach each other below a distance ruled by the Born-Infeld constant.

  1. Born Too Soon: Care for the preterm baby

    OpenAIRE

    Joy E Lawn; Davidge, Ruth; Paul, Vinod K; Xylander, Severin von; de Graft Johnson, Joseph; Costello, Anthony; Mary V Kinney; Segre, Joel; Molyneux, Liz

    2013-01-01

    As part of a supplement entitled "Born Too Soon", this paper focuses on care of the preterm newborn. An estimated 15 million babies are born preterm, and the survival gap between those born in high and low income countries is widening, with one million deaths a year due to direct complications of preterm birth, and around one million more where preterm birth is a risk factor, especially amongst those who are also growth restricted. Most premature babies (>80%) are between 32 and 37 weeks of g...

  2. Nonlinear Electrodynamics with Singularities (Modernized Born-Infeld Electrodynamics)

    OpenAIRE

    Chernitskii, Alexander A.

    1997-01-01

    Born-Infeld nonlinear electrodynamics are considered. Main attention is given to existence of singular point at static field configuration that M.Born and L.Infeld are considered as a model of electron. It is shown that such singularities are forbidden within the framework of the Born-Infeld model. It is proposed a modernized action that make possible an existence of the singularities. It is obtained main relations in view of the singularities. In initial approximation this model gives the us...

  3. First-born siblings show better second language skills than later born siblings.

    Science.gov (United States)

    Keller, Karin; Troesch, Larissa M; Grob, Alexander

    2015-01-01

    We examined the extent to which three sibling structure variables number of siblings, birth order, and presence of an older sibling at school age are linked to the second language skills of bilingual children. The research questions were tested using an ethnically heterogeneous sample of 1209 bilingual children with German as a second language. Controlling for children's age, sex, nationality, number of children's books at home, family language and parental German language skills, hierarchical regression analyses showed an inverse relationship between the number of siblings and second language skills: the more siblings a child had, the lower was his/her second language proficiency. This relationship was mediated by attendance in early education institutions. Moreover, first-born siblings showed better second language skills than later born siblings. The current study revealed that the resource dilution model, i.e., the decrease in resources for every additional sibling, holds for second language acquisition. Moreover, the results indicate that bilingual children from families with several children benefit from access to early education institutions. PMID:26089806

  4. First-born siblings show better second language skills than later born siblings

    Directory of Open Access Journals (Sweden)

    Karin eKeller

    2015-06-01

    Full Text Available We examined the extent to which three sibling structure variables number of siblings, birth order and presence of an older sibling at school age are linked to the second language skills of bilingual children. The research questions were tested using an ethnically heterogeneous sample of 1209 bilingual children with German as a second language. Controlling for children’s age, sex, nationality, number of children’s books at home, family language and parental German language skills, hierarchical regression analyses showed an inverse relationship between the number of siblings and second language skills: The more siblings a child had, the lower was his/her second language proficiency. This relationship was mediated by attendance in early education institutions. Moreover, first-born siblings showed better second language skills than later born siblings.The current study revealed that the resource dilution model, i.e., the decrease in resources for every additional sibling, holds for second language acquisition. Moreover, the results indicate that bilingual children from families with several children benefit from access to early education institutions.

  5. 75 FR 3859 - Safety Zone; Baltimore Captain of Port Zone

    Science.gov (United States)

    2010-01-25

    ..., 2008 issue of the Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Baltimore Captain of Port Zone AGENCY... establishing a temporary safety zone in all navigable waters of the Captain of the Port Baltimore zone....

  6. The shape of things to come? Obesity prevalence among foreign-born vs. US-born Mexican youth in California

    OpenAIRE

    Buttenheim, Alison M; Pebley, Anne R.; Hsih, Katie; Chung, Chang Y.; Goldman, Noreen

    2012-01-01

    Obesity among the Mexican-origin adult population in the US has been associated with longer stays in the US and with being US- vs. Mexican-born, two proxies for acculturation. This pattern is less clear for Mexican-origin children and young adults: recent evidence suggests that it may be reversed, with foreign-born Mexican youth in the US at higher risk of obesity than their US-born Mexican–American counterparts. The objective of this study is to evaluate the hypothesis that the immigrant adv...

  7. Born Globals and Active Online Internationalization : A closer look on the effects of active online internationalization for Swedish Born Globals

    OpenAIRE

    Jallow, Antouman; Abraha, Adam

    2013-01-01

    Research pertaining to the role of active online internationalization (AOI) in the context of Born Globals has been shown to be an under-researched area of study. This compelled us to explore the possible benefits and challenges that may come from pursuing AOI for Swedish Born Globals. Our theoretical framework combined literature concerning Born Globals and their rapid internationalization with the notion of learning advantages of newness and literature regarding AOI into a theoretical model...

  8. Surface-Borne Time-of-Reception Measurements (STORM) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Invocon proposes the Surface-borne Time-Of-Reception Measurements (STORM) system as a method to locate the position of lightning strikes on aerospace vehicles....

  9. Thin-shell wormholes in Einstein-Born-Infeld theory

    CERN Document Server

    Eiroa, Ernesto F

    2015-01-01

    We construct spherically symmetric thin-shell wormholes with a generalized Chaplygin gas at the throat, in Born-Infeld electrodynamics coupled to Einstein gravity. We analyze their stability under radial perturbations.

  10. Developmental milestones in post-term born children

    DEFF Research Database (Denmark)

    Olesen, Annette Wind; Olsen, Jørn; Zhu, Jinliang

    DEVELOPMENTAL MILESTONES IN POST-TERM BORN CHILDREN Annette Wind Olesen (1), Jorn Olsen (2), Jinliang Zhu (2) (1)Institute of Regional Health Research, University of Southern Denmark, (2)The Danish Epidemiology Science Centre, Aarhus University Objective: To examine the timing of reaching...... developmental milestones in children born post-term. Design: Cohort study. Material: The Danish National Birth Cohort; children born between 1997 and 2003. Data was obtained from a cohort of 92,892 pregnancies participating in the first pregnancy interview. All singletons born in gestational week 39-45 were...... identified. The study was then restricted to children who participated in an interview at age of approximately 18 months and had information on at least one developmental milestone, e.g. sitting without support, using two word sentences. We excluded children of mothers with chronic diseases from the final...

  11. Metabolic syndrome in children born small-for-gestational age

    Directory of Open Access Journals (Sweden)

    María Isabel Hernández

    2011-11-01

    Full Text Available Being born small-for-gestational age and a rapid increase in weight during early childhood and infancy has been strongly linked with chronic diseases, including metabolic syndrome, which has been related to intrauterine life environment and linked to epigenetic fetal programming. Metabolic syndrome includes waist circumference > 90th percentile for age, sex and race, higher levels of blood pressure, triglycerides and fasting glucose, and low levels of HDL-cholesterol. Insulin resistance may be present as early as 1 year of age, and obesity and/or type 2 diabetes are more prevalent in those born SGA than those born AGA. The programming of adaptive responses in children born SGA includes an association with increased blood pressure, changes in endothelial function, arterial properties and coronary disease. Early interventions should be directed to appropriate maternal nutrition, before and during pregnancy, promotion of breast feeding, and prevention of rapid weight gain during infancy, and to promote a healthy lifestyle.

  12. Girl with Zika Birth Defect Born At New Jersey Hospital

    Science.gov (United States)

    ... medlineplus/news/fullstory_159145.html Girl With Zika Birth Defect Born at New Jersey Hospital The mother was ... Jersey hospital to a baby girl with the birth defect characteristic of the disease, officials said. The baby ...

  13. Heat Engines for Dilatonic Born-Infeld Black Holes

    CERN Document Server

    Bhamidipati, Chandrasekhar

    2016-01-01

    In the context of dilaton coupled Einstein gravity with negative cosmological constant and a Born-Infeld field, we study heat engines where charged black hole is the working substance and the mechanical work is done via the $pdV$ terms present in the first law of extended gravitational thermodynamics. Efficiency is analyzed as a function of dilaton and Born-Infeld couplings, and results compared with Einstein-Maxwell theory.

  14. Ray-Born Modelling and Full Waveform Inversion

    OpenAIRE

    Tengesdal, Hans Christian

    2013-01-01

    Seismic forward modelling is used to simulate seismic wave propagation in the subsurface. Common modelling techniques include methods such as the ray-Born approximation and the finite difference method. In this thesis I present a comparison between the ray-Born approximation and the finite difference method. This comparison consists of computing synthetic seismograms using both methods for several seismic velocity models and performing a comparison between them. The main ...

  15. Complex method for approximated solutions to Born-Infeld equation

    CERN Document Server

    Ferraro, Rafael

    2015-01-01

    We display the method to solve the Born-Infeld equation in the complex plane. As the exact solution is obtained in an implicit form, we turn it into an explicit form by means of a perturbative procedure which takes care of secular behaviors common to this kind of approximations. We apply the method to build solutions to Born-Infeld electrodynamics. In particular, we study BI electromagnetic waves at interfaces, with the aim of searching for effects susceptible of experimental detection.

  16. Transmission mechanisms of an emerging insect-borne rickettsial pathogen

    OpenAIRE

    Brown, Lisa D.; Kaikhushroo H Banajee; Lane D Foil; Macaluso, Kevin R.

    2016-01-01

    Background Vector-borne pathogens must overcome arthropod infection and escape barriers (e.g. midgut and salivary glands) during the extrinsic incubation period (EIP) before subsequent transmission to another host. This particular timespan is undetermined for the etiological agent of flea-borne spotted fever (Rickettsia felis). Artificial acquisition of R. felis by blood-feeding cat fleas revealed dissemination to the salivary glands after seven days; however, this length of time is inconsist...

  17. How can newly born rapidly rotating neutron stars become magnetars?

    OpenAIRE

    Cheng, Quan; Yu, Yun-Wei

    2014-01-01

    In a newly born (high-temperature and Keplerian rotating) neutron star, r-mode instability can lead to stellar differential rotation, which winds the seed poloidal magnetic field ($\\sim 10^{11}$ G) to generate an ultra-high ($\\sim 10^{17}$ G) toroidal field component. Subsequently, by succumbing to the Tayler instability, the toroidal field could be partially transformed into a new poloidal field. Through such dynamo processes, the newly born neutron star with sufficiently rapid rotation coul...

  18. Emerging Vector-borne Diseases in a Changing Environment

    OpenAIRE

    ÖZER, Nurdan

    2005-01-01

    Vector-borne infectious diseases are emerging or resurging as a result of changes in public health policy, demographic and societal changes, insecticide and drug resistance, shift in emphasis from prevention to emergency response, genetic changes in pathogens in the last two decades of the twentieth century. Climate changes also can influence the emergence and reemergence of these diseases which are malaria, dengue, yellow fever, plague, filariasis, louse-borne typhus, lyme disease, trypanoso...

  19. Emerging Vector-Borne Diseases – Incidence through Vectors

    OpenAIRE

    Savić, Sara; Vidić, Branka; Grgić, Zivoslav; Potkonjak, Aleksandar; Spasojevic, Ljubica

    2014-01-01

    Vector-borne diseases use to be a major public health concern only in tropical and subtropical areas, but today they are an emerging threat for the continental and developed countries also. Nowadays, in intercontinental countries, there is a struggle with emerging diseases, which have found their way to appear through vectors. Vector-borne zoonotic diseases occur when vectors, animal hosts, climate conditions, pathogens, and susceptible human population exist at the same time, at the same pla...

  20. Success Factors in Western and Chinese Born Global Companies

    OpenAIRE

    Svante Andersson; Mike Danilovic; Hanjun Huang

    2015-01-01

    Born Global firms are becoming increasingly more important in terms of internationalization, innovation, ability to grow and providing employment. Most of the previous research about Born Globals is done in North America, Europe or Australia, all these being developed industrialized countries but not developing countries or emerging markets. However, the emerging markets in general, and the Chinese in particular, have become very important for the world economy. Our aim is t...

  1. Black holes in Born-Infeld extended new massive gravity

    International Nuclear Information System (INIS)

    In this paper we find different types of black holes for the Born-Infeld extended new massive gravity. Our solutions include (un)charged warped (anti-)de Sitter black holes for four and six derivative expanded action. We also look at the black holes in unexpanded Born-Infeld action. In each case we calculate the entropy, angular momentum and mass of the black holes. We also find the central charges for the conformal field theory duals.

  2. Arthropod Borne Diseases in Imposed War during 1980-88

    OpenAIRE

    Khoobdel, M; A Mehrabi Tavana; H Vatandoost; MR Abaei

    2008-01-01

    Background: Personnel of military forces have close contact with natural habitat and usually encounter with bite of arthropods and prone to be infected with arthropod borne diseases. The imposed war against Iran was one of the most important and the longest war in the Middle East and even in the world and military people faced various diseases. The aim of this study was to review prevalence of arthropod borne diseases and to collect relevant information and valuable experiences during the imp...

  3. Air travel and vector-borne disease movement.

    Science.gov (United States)

    Tatem, A J; Huang, Z; Das, A; Qi, Q; Roth, J; Qiu, Y

    2012-12-01

    Recent decades have seen substantial expansions in the global air travel network and rapid increases in traffic volumes. The effects of this are well studied in terms of the spread of directly transmitted infections, but the role of air travel in the movement of vector-borne diseases is less well understood. Increasingly however, wider reaching surveillance for vector-borne diseases and our improving abilities to map the distributions of vectors and the diseases they carry, are providing opportunities to better our understanding of the impact of increasing air travel. Here we examine global trends in the continued expansion of air transport and its impact upon epidemiology. Novel malaria and chikungunya examples are presented, detailing how geospatial data in combination with information on air traffic can be used to predict the risks of vector-borne disease importation and establishment. Finally, we describe the development of an online tool, the Vector-Borne Disease Airline Importation Risk (VBD-Air) tool, which brings together spatial data on air traffic and vector-borne disease distributions to quantify the seasonally changing risks for importation to non-endemic regions. Such a framework provides the first steps towards an ultimate goal of adaptive management based on near real time flight data and vector-borne disease surveillance. PMID:22444826

  4. Caracterización de la proliferación celular en las zonas subventriculares y de la evolución del infarto mediante espectroscopía de resonancia magnética en un modelo preclínico de isquemia cerebral

    OpenAIRE

    Jiménez Xarrié, Elena

    2013-01-01

    El ictus es una patología con una elevada incidencia en la población y los pacientes afectados sufren secuelas que les causan algún tipo de discapacidad. A nivel terapéutico, la posibilidad de incidir sobre la evolución de la enfermedad es a día de hoy aún escasa. Se ha descrito que la neurogénesis, la generación de nuevas neuronas con capacidad para migrar a la zona afectada, aumenta en las zonas subventriculares (ZSVs) y el hipocampo tras un infarto cerebral, en modelos animales y en humano...

  5. Zones of emotional labour

    DEFF Research Database (Denmark)

    Strøbæk, Pernille Solveig

    2011-01-01

    The paper suggests that due to the difficult nature of their work public family law caseworkers are to be included in the definition of emotional labour even though they are omitted by Hochschild. Based upon a review of the structures involved in emotional labour an explorative qualitative study is...... put forth among 25 Danish public family law caseworkers. The study points to personal, professional, and social zones of emotional labour through which the caseworkers carry out their work. Emotional labour zones mark emotion structures that may be challenging due to complex emotional intersections...

  6. ZoneLib

    DEFF Research Database (Denmark)

    Jessen, Jan Jacob; Schiøler, Henrik

    2006-01-01

    We present a dynamic model for climate in a livestock building divided into a number of zones, and a corresponding modular Simulink library (ZoneLib). While most literature in this area consider air flow as a control parameter we show how to model climate dynamics using actual control signals...... for the ventilation equipment. To   overcome a shortcoming in Simulink to solve algebraic equations and matrix inversions, we have developed the library inspired by the so called dynamic node technique. We present simulation results using the presented library, and concludes with visions for further...

  7. Grid zone drone

    OpenAIRE

    McCarthy, Clive; Cooper, Graham; Field, James; Thayne, Martyn; Vickers, Richard

    2014-01-01

    From 16th – 19th October 2014, co_LAB presented its newest creation, Grid Zone Drone, at Kinetica – an international exhibition providing a global platform for galleries, curatorial groups, design studios and artists working with new media art. 2014 marked the third consecutive year that the University of Lincoln has been represented at the global art fair. Grid Zone Drone represents a continuation of the group’s research into ‘drone culture’, and explores the detachment of the drone withi...

  8. Neighborhood Amenities, Satisfaction, and Perceived Livability of Foreign-Born and Native-Born U.S. Residents

    Directory of Open Access Journals (Sweden)

    Yanmei LI

    2012-05-01

    Full Text Available Neighborhood amenities and satisfaction have been widely discussed in previous research, but little attention has focused on how they relate to residents’ nativity status. This research will contribute to the scanty literature in this specific matter and help us further understand the place identity of immigrants. Using the 2007 American Housing Survey, bivariate and multivariate regression analysis, this research finds that the difference in neighborhood amenities between native-born and foreign-born residents reflects the differences in demand for favorable amenities and convenience, respectively. Compared to native-born residents, foreign-born residents tend to live in neighborhoods with less desirable amenities, but residents are more satisfied with the livability of their neighborhoods. However, when controlling for residential characteristics the difference in perceived neighborhood livability becomes insignificant. This indicates that consistent with some of the previous studies socioeconomic characteristics, instead of nativity status, determine the disparities in neighborhood amenities, neighborhood satisfaction, and perceived neighborhood livability among foreign-born and native-born residents.

  9. Evaluation of the antibacterial activity of essential oil and aqueous and ethanolic extracts of Quercus infectoria leaves on food-borne pathogenic bacteria.

    Directory of Open Access Journals (Sweden)

    Nabi Shariatifar

    2014-10-01

    Full Text Available Food-borne pathogens are group of micro-organisms that cause food-borne illness thus, the research for finding effective natural product against this infection is necessary. The purpose of this study was to determine antibacterial activity of essential oil and ethanolic and aqueous extracts Quercus infectoria against some important food borne bacteria. In this study, antibacterial activity of extracts and essential oil was evaluated against bacteria (Escherichia coli, Staphylococcus aureus, Bacillus cereus, Yersinia entercolitica, Salmonella typhi and Vibrio cholera using disc diffusion method. Then broth micro-dilution method was used to determine their minimal inhibitory concentration (MIC and minimal bactericidal concentration (MBC. The data was expressed as the mean and the standard deviation; and they were statistically analyzed by ANOVA using SPSS software (P<0.05. Result showed that ethanol extract of Quercus infectoria was found to be the most effective against B. cereus strains (inhibition zone=16.85±0.65 mm than Yersinia entercolitica strains (inhibition zone=14.15 ±0.75mm. Aqueous extract of Quercus infectoria was found to be the most effective against B. cereus strains (inhibition zone=7.25±0.45 mm than Yersinia entercolitica strains (inhibition zone=14.45 ±0.21mm. The MIC values of the essential oil, ethanolic and aqueous extracts against B. cereus were 0.064, 0.512, 0.256 μg/ml and against salmonella typhi were 0.256, 0.1024, 0.1024μg/ml, respectively. Essential oil and extracts of Quercus infectoria leave showed a good antimicrobial activity against food borne pathogens. Therefore, they can be used in food preservation systems to inhibit the growth of these bacteria and improve food quality and safety.

  10. DNS zones revisited

    NARCIS (Netherlands)

    Wanrooij, van Ward; Pras, Aiko; Delgado Kloos, Carlos

    2005-01-01

    Recent research [Pap04b] suggests DNS reliability and performance is not up to the levels it should be due to misconfigurations. This paper checks the configuration of nameserver zones against additional requirements, recommendations and best-practices. It shows that almost one in four domains fails

  11. Differential regulation of cell proliferation in neurogenic zones in mice lacking cystine transport by xCT

    International Nuclear Information System (INIS)

    The cystine/glutamate exchanger (xCT) supplies intracellular cyst(e)ine for the production of glutathione, a major cellular anti-oxidant. xCT is enriched in brain regions associated with neurogenesis. Previous studies have shown that the malfunction of this protein greatly attenuates cell proliferation in vitro and is associated with brain atrophy in vivo. Using mice that are homozygous for a function-blocking deletion in xCT (Sut mice), we examined in vivo the role of xCT in cell proliferation in neurogenic regions of the subventricular zone (SVZ) and denate gyrus (DG) in the adult brain. Our results indicate that a high level of cellular proliferation in the adult brain persists even in the absence of functional xCT. Furthermore, in both young adult and middle-aged mice (3 and 11 months old), rates of SVZ cell proliferation were comparable between Sut and wild-type controls, although there was trend towards reduced proliferation in Sut mice (12% and 9% reduction, respectively). To our surprise, rates of cell proliferation in the DG were elevated in both 3- and 11-month-old Sut mice relative to controls (22% and 28% increase, respectively). These results demonstrate that xCT expression plays a role in regulating cellular proliferation in the DG, but not the SVZ of adult mice. Furthermore, unlike previous in vitro studies, our in vivo observations clearly indicate that xCT is not essential for ongoing cellular proliferation

  12. Firms' degree of born-globalness, international entrepreneurial orientation and export performance

    DEFF Research Database (Denmark)

    Servais, Per; Kuivalainen, Olli; Sundqvist, Sanna

    2007-01-01

    Despite the recent increase in 'born-global' studies, there has been little research on how the scale and scope of being a born-global firm affects performance: most of the earlier research takes no account either the number of or the distances between the countries on firm or export performance...... these two born-global pathways. The results of our empirical study on 185 Finnish exporting firms show that those that qualified as true born-globals had better export performance. Furthermore, depending on the degree of born-globalness, different dimensions of EO were of importance........ This article begins with a review of the existing literature on born-globals, and subsequently explores the relationship between entrepreneurial orientation (EO) and two different born-global strategies, namely true born-global and apparently born-global (born-international), and the effectiveness of...

  13. Zoning Districts, Countywide Zoning Shapefile, Published in unknown, Cleveland County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Zoning Districts dataset as of unknown. It is described as 'Countywide Zoning Shapefile'. Data by this publisher are often provided in State Plane coordinate...

  14. Empowerment Zones and Enterprise Districts - MDC_EnterpriseZone

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — Polygon feature class of Miami Dade County Enterprise Zones. Enterprise Zones are special areas in the county where certain incentives from the State are available...

  15. Twin Convergence Zones

    Science.gov (United States)

    2002-01-01

    NASA's QuikSCAT satellite has confirmed a 30-year old largely unproven theory that there are two areas near the equator where the winds converge year after year and drive ocean circulation south of the equator. By analyzing winds, QuikSCAT has found a year-round southern and northern Intertropical Convergence Zone. This find is important to climate modelers and weather forecasters because it provides more detail on how the oceans and atmosphere interact near the equator. The Intertropical Convergence Zone (ITCZ) is the region that circles the Earth near the equator, where the trade winds of both the Northern and Southern Hemispheres come together. North of the equator, strong sun and warm water of the equator heats the air in the ITCZ, drawing air in from north and south and causing the air to rise. As the air rises it cools, releasing the accumulated moisture in an almost perpetual series of thunderstorms. Satellite data, however, has confirmed that there is an ITCZ north of the equator and a parallel ITCZ south of the equator. Variation in the location of the ITCZ is important to people around the world because it affects the north-south atmospheric circulation, which redistributes energy. It drastically affects rainfall in many equatorial nations, resulting in the wet and dry seasons of the tropics rather than the cold and warm seasons of higher latitudes. Longer term changes in the ITCZ can result in severe droughts or flooding in nearby areas. 'The double ITCZ is usually only identified in the Pacific and Atlantic Oceans on a limited and seasonal basis,' said Timothy Liu, of NASA's Jet Propulsion Laboratory and California Institute of Technology, Pasadena, Calif., and lead researcher on the project. In the eastern Pacific Ocean, the southern ITCZ is usually seen springtime. In the western Atlantic Ocean, the southern ITCZ was recently clearly identified only in the summertime. However, QuikSCAT's wind data has seen the southern ITCZ in all seasons across the

  16. Cross sections for electron-hydrogen collisions in the Born approximation to the reactance matrix

    International Nuclear Information System (INIS)

    Born partial-wave integrals have been performed for a range of energies and total cross sections are presented for electron-hydrogen-atom excitation both in the conventional first Born approximation (Born I) and the unitarised Born approximation (Born II). Exchange effects are not included. With the exception of exact resonance-allowed transitions (n = n', lambda = 1) results are presented for all transitions between hydrogen-atom states whose principal quantum number is less than or equal to 4. (author)

  17. Oral health of children born small for gestational age.

    LENUS (Irish Health Repository)

    O'Connell, A C

    2010-10-01

    We sought to evaluate the oral health status of children born small for gestational age (SGA). Children now aged 4-8 years who were born SGA (birth weight < -2 SDS) were examined using standardised criteria. The parents completed a structured oral health questionnaire. Twenty females and 25 males, mean age 72.1 months, and mean birth weight 2.1 kg, participated in the study. Poor appetite was a concern; 32 (71%) children snacked between meals and 14 (30%) used carbonated beverages more than 3 times daily. Erosion was present in 9 (20%) children. Dental decay occurred in 22 (47%) children with 92% being untreated. Eight children had more than 5 decayed teeth. It is essential that clinicians working with children born SGA include oral health within the general health surveillance and refer these children for a dental assessment within the first 2 years to support parents in establishing safe feeding patterns for their children.

  18. Born reciprocity in string theory and the nature of spacetime

    International Nuclear Information System (INIS)

    After many years, the deep nature of spacetime in string theory remains an enigma. In this Letter we incorporate the concept of Born reciprocity in order to provide a new point of view on string theory in which spacetime is a derived dynamical concept. This viewpoint may be thought of as a dynamical chiral phase space formulation of string theory, in which Born reciprocity is implemented as a choice of a Lagrangian submanifold of the phase space, and amounts to a generalization of T-duality. In this approach the fundamental symmetry of string theory contains phase space diffeomorphism invariance and the underlying string geometry should be understood in terms of dynamical bi-Lagrangian manifolds and an apparently new geometric structure, somewhat reminiscent of para-quaternionic geometry, which we call Born geometry.

  19. Born approximation in linear-time invariant system

    CERN Document Server

    Gumjudpai, Burin

    2015-01-01

    Linear-time invariant (LTI) oscillation systems such as forced mechanical vibration, series RLC and parallel RLC circuits can be solved by using simplest initial conditions or employing of Green's function of which knowledge of initial condition of the force term is needed. Here we show a mathematical connection of the LTI system and the Helmholtz equation form of the time-independent Schr\\"{o}dinger equation in quantum mechanical scattering problem. We apply Born approximation in quantum mechanics to obtain LTI general solution in form of infinite Born series which can be expressed as a series of one-dimensional Feynman graphs. Conditions corresponding to the approximation are given for the case of harmonic driving force. The Born series of the harmonic forced oscillation case are derived by directly applying the approximation to the LTI system or by transforming the LTI system to Helmholtz equation prior to doing the approximation.

  20. Control of ground-borne noise and vibration

    Science.gov (United States)

    Wilson, G. P.; Saurenman, H. J.; Nelson, J. T.

    1983-03-01

    Ground-borne noise and vibration created by train operations is one of the major environmental problems faced by rail transit systems. In the past 10-20 years there have been a number of developments in the control and prediction of ground-borne noise and vibration although it is evident that further research is needed. In this paper the focus is on two methods of controlling the vibration radiated by the transit structure. First is the use of floating slab trackbeds, a method that has proven to be very effective at reducing vibration at frequencies above the resonance frequency of the floating slab system. Second is to modify the design of transit car bogies such that the wheel/rail forces are reduced. Although this method is still in the exploratory phase it has been shown that proper design of the bogie suspension can significantly reduce the levels of ground-borne noise and vibration.

  1. Developmental delay at 12 months in children born extremely preterm

    DEFF Research Database (Denmark)

    Lando, Ane; Klamer, Anja; Jonsbo, Finn;

    2005-01-01

    for comparison. The interview was conducted by NICU staff. To validate the R-PDQ, parents of 22 children in the preterm group and parents of 19 children in the reference group conducted an Ages and Stages Questionnaire (ASQ) when their children had reached the age of 3-3(1/2) y. RESULTS: The R-PDQ was......AIM: To evaluate the feasibility and validity of a structured telephone interview to assess the development of children born extremely preterm. METHODS: The parents of 88 children born with a gestational age below 28 wk admitted to the neonatal intensive care unit (NICU) at Rigshospitalet......, Copenhagen, were interviewed by telephone when their child was 1 y of age, corrected for preterm birth. A fully structured questionnaire on psychomotor function was used (Revised Prescreening Developmental Questionnaire (R-PDQ)). The parents of 30 children born at term without complications were interviewed...

  2. Born reciprocity in string theory and the nature of spacetime

    Energy Technology Data Exchange (ETDEWEB)

    Freidel, Laurent, E-mail: lfreidel@perimeterinstitute.ca [Perimeter Institute for Theoretical Physics, 31 Caroline St., N, Ontario N2L 2Y5, Waterloo (Canada); Leigh, Robert G., E-mail: rgleigh@uiuc.edu [Department of Physics, University of Illinois, 1110 West Green St., Urbana, IL 61801 (United States); Minic, Djordje, E-mail: dminic@vt.edu [Department of Physics, Virginia Tech, Blacksburg, VA 24061 (United States)

    2014-03-07

    After many years, the deep nature of spacetime in string theory remains an enigma. In this Letter we incorporate the concept of Born reciprocity in order to provide a new point of view on string theory in which spacetime is a derived dynamical concept. This viewpoint may be thought of as a dynamical chiral phase space formulation of string theory, in which Born reciprocity is implemented as a choice of a Lagrangian submanifold of the phase space, and amounts to a generalization of T-duality. In this approach the fundamental symmetry of string theory contains phase space diffeomorphism invariance and the underlying string geometry should be understood in terms of dynamical bi-Lagrangian manifolds and an apparently new geometric structure, somewhat reminiscent of para-quaternionic geometry, which we call Born geometry.

  3. Born Reciprocity in String Theory and the Nature of Spacetime

    CERN Document Server

    Freidel, Laurent; Minic, Djordje

    2013-01-01

    After many years, the deep nature of spacetime in string theory remains an enigma. In this letter we incorporate the concept of Born reciprocity in order to provide a new point of view on string theory in which spacetime is a derived dynamical concept. This viewpoint may be thought of as a dynamical chiral phase space formulation of string theory, in which Born reciprocity is implemented as a choice of a Lagrangian submanifold of the phase space, and amounts to a generalization of T-duality. In this approach the fundamental symmetry of string theory contains phase space diffeomorphism invariance and the underlying string geometry should be understood in terms of dynamical bi-Lagrangian manifolds and an apparently new geometric structure, somewhat reminiscent of para-quaternionic geometry, which we call Born geometry.

  4. Nordic climate change: data for modeling vector borne diseases

    DEFF Research Database (Denmark)

    Kristensen, Birgit; Bødker, Rene

    derivatives were calculated in order to assess the geographical and seasonal variation in the area. In order to evaluate the response of vector borne diseases to possible future climate changes and the subsequent potential spread into new areas, daily temperature predictions (mean, min and max) for three 20......The distribution of vector species is generally restricted by a range of different climatic and geographical factors, while the development and spread of the vector-borne diseases (veterinary and zoonotic) is often primarily temperature driven. Thus temperature and its derivatives are key factors...... in the modelling of vector-borne diseases. This puts a high demand on the quality and accuracy of the temperature data to be used as input in such models. In order to best capture the local temporal and spatial variation in the temperature surfaces, accurate daily temperature data were used in the present project...

  5. Ethnic Identity and Its Relation to Personal Self-Esteem: A Comparison of Canadian-Born and Foreign-Born Chinese Adolescents.

    Science.gov (United States)

    Lay, Clarry; Verkuyten, Maykel

    1999-01-01

    Examines ethnic identity and its relation to personal self-esteem by comparing Chinese adolescents who immigrated to Canada and Canadian-born Chinese adolescents. Finds that aspects of collective self-esteem were positively related to personal self-esteem for the foreign-born group, not the Canadian-born group. (CMK)

  6. Perceived Job Skill Limitations and Participation in Education and Training Opportunities: Differences between Us Native-Born and Non-Native-Born Individuals

    Science.gov (United States)

    Smith, M. Cecil; Smith, Thomas J.

    2010-01-01

    Data from the 2003 National Assessment of Adult Literacy were examined to determine if non-native-born adults in the US differ from their native-born counterparts in (1) participation in work-related training or education, and (2) perceptions that specific skills limit their job opportunities. Results indicated that non-native-born persons were…

  7. Cape Verde Frontal Zone

    OpenAIRE

    Zenk, Walter; Klein, Birgit; Schröder, Michael

    1991-01-01

    The term Cape Verde Frontal Zone is introduced to characterize the southeastern corner of the subtropical gyre circulation in the North Atlantic Ocean far west of the upwelling area off the Mauretanean shelf. Two water mass fronts, one overlying the other, are identified with a quasi-synoptic set of CTD-OZ and nutrient data from November 1986. In the warm water sphere we encounter North and South Atlantic Central Water (NACWISACW) superimposed on extensions of Mediterranean outflow and Antarc...

  8. Emerging vector borne diseases – incidence through vectors

    Directory of Open Access Journals (Sweden)

    Sara eSavic

    2014-12-01

    Full Text Available Vector borne diseases use to be a major public health concern only in tropical and subtropical areas, but today they are an emerging threat for the continental and developed countries also. Nowdays, in intercontinetal countries, there is a struggle with emerging diseases which have found their way to appear through vectors. Vector borne zoonotic diseases occur when vectors, animal hosts, climate conditions, pathogens and susceptible human population exist at the same time, at the same place. Global climate change is predicted to lead to an increase in vector borne infectious diseases and disease outbreaks. It could affect the range and popultion of pathogens, host and vectors, transmission season, etc. Reliable surveilance for diseases that are most likely to emerge is required. Canine vector borne diseases represent a complex group of diseases including anaplasmosis, babesiosis, bartonellosis, borreliosis, dirofilariosis, erlichiosis, leishmaniosis. Some of these diseases cause serious clinical symptoms in dogs and some of them have a zoonotic potential with an effect to public health. It is expected from veterinarians in coordination with medical doctors to play a fudamental role at primeraly prevention and then treatment of vector borne diseases in dogs. The One Health concept has to be integrated into the struggle against emerging diseases.During a four year period, from 2009-2013, a total number of 551 dog samples were analysed for vector borne diseases (borreliosis, babesiosis, erlichiosis, anaplasmosis, dirofilariosis and leishmaniasis in routine laboratory work. The analysis were done by serological tests – ELISA for borreliosis, dirofilariosis and leishmaniasis, modified Knott test for dirofilariosis and blood smear for babesiosis, erlichiosis and anaplasmosis. This number of samples represented 75% of total number of samples that were sent for analysis for different diseases in dogs. Annually, on avarege more then half of the samples

  9. Persistence mechanisms in tick-borne diseases : tick-borne diseases

    Directory of Open Access Journals (Sweden)

    A.F. Barbet

    2009-09-01

    Full Text Available The use of new, highly sensitive diagnostic methods has revealed persistent infections to be a common feature of different tick-borne diseases, such as babesiosis, anaplasmosis and heartwater. Antigenic variation can contribute to disease persistence through the continual elaboration of new surface structures, and we know in several instances how this is achieved. Known or suspected mechanisms of persistence in babesial parasites include cytoadhesion and rapid variation of the adhesive ligand in Babesia bovis and genetic diversity in several merozoite stage proteins of different Babesia spp. In Anaplasma, extensive variation in the pfam01617 gene family accompanies cycling of organism levels in chronic infection. One result from the pioneering research at Onderstepoort is the definition of a related polymorphic gene family that is likely involved in immunity against heartwater disease. We are beginning to understand the sizes of the antigenic repertoires and full definition is close, with the possibility of applying simultaneous high-throughput sequencing to the order of 1 000 small genomes. We also, for the first time, can consider modifying these genomes and looking at effects on persistence and virulence. However, important biological questions remain unanswered; for example, why we are seeing a new emerging Anaplasma infection of humans and is infection of endothelial cells by Anaplasma significant to persistence in vivo.

  10. Radiant zone heated particulate filter

    Science.gov (United States)

    Gonze, Eugene V [Pinckney, MI

    2011-12-27

    A system includes a particulate matter (PM) filter including an upstream end for receiving exhaust gas and a downstream end. A radiant zoned heater includes N zones, where N is an integer greater than one, wherein each of the N zones includes M sub-zones, where M is an integer greater than or equal to one. A control module selectively activates at least a selected one of the N zones to initiate regeneration in downstream portions of the PM filter from the one of the N zones, restricts exhaust gas flow in a portion of the PM filter that corresponds to the selected one of the N zones, and deactivates non-selected ones of the N zones.

  11. Higher-order symplectic Born-Oppenheimer molecular dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Niklasson, Anders [Los Alamos National Laboratory; Bock, Nicolas [Los Alamos National Laboratory; Challacombe, Matt [Los Alamos National Laboratory; Odell, Anders [RIT; Delin, Anna [RIT; Johansson, Borje [RIT

    2009-01-01

    The extended Lagrangian formulation of time-reversible Born-Oppenheimer molecular dynamics (TR-BOMD) enables the use of geometric integrators in the propagation of both the nuclear and the electronic degrees of freedom on the Born-Oppenheimer potential energy surface. Different symplectic integrators up to the 6th order have been adapted and optimized to TR-BOMD in the framework of ab initio self-consistent-field theory. It is shown how the accuracy can be significantly improved compared to a conventional Verlet integration at the same level of computational cost, in particular for the case of very high accuracy requirements.

  12. Thermodynamics of Third Order Lovelock-Born-Infeld Black Holes

    Institute of Scientific and Technical Information of China (English)

    李鹏; 岳瑞宏; 邹德成

    2011-01-01

    We here explore black holes in the third order Lovelock gravity coupling with nonlinear Born-Infeld electro- magnetic field. Considering special second and third order coefficients (&g = 363 = a2), we analyze the thermodynamics of third order Lovelock-Born-Infeld black holes and, in 7-dimensional AdS space-time, discuss the stability of black holes in different event horizon structures. We find that the cosmological constant A plays an important role in the distribution of black hole stable regions.

  13. Wormhole geometries in Eddington-Inspired Born-Infeld gravity

    Science.gov (United States)

    Harko, Tiberiu; Lobo, Francisco S. N.; Mak, M. K.; Sushkov, Sergey V.

    2015-10-01

    Eddington-inspired Born-Infeld (EiBI) gravity is a recently proposed modified theory of gravity, based on the classic work of Eddington and Born-Infeld nonlinear electrodynamics. In this paper, we consider the possibility that wormhole geometries are sustained in EiBI gravity. We present the gravitational field equations for an anisotropic stress-energy tensor and consider the generic conditions, for the auxiliary metric, at the wormhole throat. In addition to this, we obtain an exact solution for an asymptotically flat wormhole.

  14. Dirac-Born-Infeld-Einstein theory with Weyl invariance

    CERN Document Server

    Maki, Takuya; Shiraishi, Kiyoshi

    2011-01-01

    Weyl invariant gravity has been investigated as the fundamental theory of the vector inflation. Accordingly, we consider a Weyl invariant extension of Dirac-Born-Infeld type gravity. We find that an appropriate choice of the metric removes the scalar degree of freedom which is at the first sight required by the local scale invariance of the action, and then a vector field acquires mass. Then nonminimal couplings of the vector field and curvatures are induced. We find that the Dirac-Born-Infeld type gravity is a suitable theory to the vector inflation scenario.

  15. Born-Infeld Type Extension of (Non-)Critical Gravity

    OpenAIRE

    Yi, Sang-Heon

    2012-01-01

    We consider the Born-Infeld type extension of (non-)critical gravity which is higher curvature gravity on Anti de-Sitter space with specific combinations of scalar curvature and Ricci tensor. This theory may also be viewed as a natural extension of three-dimensional Born-Infeld new massive gravity to arbitrary dimensions. We show that this extension is consistent with holographic $c$-theorem and scalar graviton modes are absent in this theory. After showing that ghost modes in the theory can ...

  16. Development and Potential of Space-Borne Doppler Wind Lidar

    Institute of Scientific and Technical Information of China (English)

    LIU Zhishen; SUN Dapeng; WU Dong; Juergen Streicher; Ines Leike

    2003-01-01

    The advantage of lidar over other wind sensors is presented in this paper. With more than 20 years research, the development of the space-borne wind lidar is reviewed. Longer-term investigation has made many technologies suitable for the wind lidar measurement from an orbital platform become mature. However, there are still some problems to be solved. In order to obtain the optimal performance in wind detection, great importance is being attached to the simulation of a virtual space-borne wind lidar system on computer as developed by NASA and ESA.

  17. Climate change and vector-borne diseases: a regional analysis.

    OpenAIRE

    Githeko, A. K.; Lindsay, S. W.; U. E. Confalonieri; Patz, J A

    2000-01-01

    Current evidence suggests that inter-annual and inter-decadal climate variability have a direct influence on the epidemiology of vector-borne diseases. This evidence has been assessed at the continental level in order to determine the possible consequences of the expected future climate change. By 2100 it is estimated that average global temperatures will have risen by 1.0-3.5 degrees C, increasing the likelihood of many vector-borne diseases in new areas. The greatest effect of climate chang...

  18. Born Global Sourcers – buying internationally right from the inception

    DEFF Research Database (Denmark)

    Rask, Morten; Servais, Per

    time researchers has identified various types of INV’s and based on the empirical work by Rasmussen et al (2010) a particular type of international new venture is isolated. The Born Global sourcers which is firms who conducts international purchasing from or near their establishment but who only to a......This article focuses on a particular type of international New Ventures (INV) the so-called Born Global Sourcers. Through the research development of the INV and by studying overview articles in the field it is concluded that nearly all research is centered on INV’s outward activities. At the same...

  19. Blasting of broken marble zones

    OpenAIRE

    Dambov, Risto; Stojceski, Igor; Dambov, Ilija

    2015-01-01

    On receipt of marble blocks appear deformed zones with presence of cracks and other deformities and very small cracks with different azimuth in the rocky massif. The fastest and economical way to bring this zone are removed by applying the methods of blasting. Before blasting, these tables - zones are limited by the block, making the cuts with diamond wire because explosive action may cause of surrounding quality marble blocks. Keywords: blasting, crashed zones, cracks, marble ...

  20. Trends and Disparities in Mortality Among Spanish-Born and Foreign-Born Populations Residing in Spain, 1999–2008

    OpenAIRE

    Moncho, Joaquin; Pereyra Zamora, Pamela; Nolasco, Andreu; Tamayo Fonseca, Nayara; Melchor-Alós, Inmaculada; Maciá Soler, Loreto

    2015-01-01

    Spain’s immigrant population has increased 380 % in the last decade, accounting for 13.1 % of the total population. This fact has led her to become during 2009 the eighth recipient country of international immigrants in the world. The aim of this article is to describe the evolution of mortality and the main causes of death among the Spanish-born and foreign-born populations residing in Spain between 1999 and 2008. Age-standardised mortality rates (ASRs), average age and comparative mortality...

  1. The Foreign-Born Parent Network, 1996-1997.

    Science.gov (United States)

    Foreign Born Network, 1997

    1997-01-01

    These six issues of a bimonthly newsletter for foreign-born parents of children in United States schools, contain articles on the following topics: the organization's activities; helping children become both bilingual and biliterate; the experience of bilingual parents; fostering links between home and school; the language of discipline; bilingual…

  2. Singular inflation from Born-Infeld-f(R) gravity

    CERN Document Server

    Elizalde, Emilio

    2016-01-01

    Accelerating dynamics from Born-Infeld-$f(R)$ gravity are studied in a simplified conformal approach without matter. Explicit unification of inflation with late-time acceleration is realized within this singular inflation approach, which is similar to Odintsov-Oikonomou singular $f(R)$ inflation. Our model turns out to be consistent with the latest release of Planck data.

  3. Roadside ecology and epidemiology of tick-borne diseases.

    Science.gov (United States)

    Haemig, Paul D; Waldenstrom, Jonas; Olsen, Bjorn

    2008-01-01

    When humans, pets and livestock walk along roads, they may encounter questing ticks and tick-borne pathogens. A new field of environmental science called road ecology can help researchers study the complex epidemiology of tick-borne diseases in the unique roadside environment. This paper reviews some of the important ways that roads alter the distribution, abundance and behaviour of wildlife species that are involved in the enzootic cycles of tick-borne diseases. Compared to the surrounding landscape, roadways often constitute a different environment and hence there is no assurance that disease risk along roads will be the same as in the adjacent landscape, or that disease control measures taken in the surrounding landscape will work in the adjacent roadway. Since roadways have their own special ecological conditions, are used extensively by the human populace and play strategic roles in community security, we believe that roadways should be one of the habitats where tick-borne diseases are studied. It is amazing that at this late period of human history, epidemiological research along such important corridors has been almost completely ignored. PMID:18618374

  4. Arthropod Borne Diseases in Imposed War during 1980-88

    Directory of Open Access Journals (Sweden)

    M Khoobdel

    2008-06-01

    Full Text Available Background: Personnel of military forces have close contact with natural habitat and usually encounter with bite of arthropods and prone to be infected with arthropod borne diseases. The imposed war against Iran was one of the most important and the longest war in the Middle East and even in the world and military people faced various diseases. The aim of this study was to review prevalence of arthropod borne diseases and to collect relevant information and valuable experiences during the imposed war.Methods: The present survey is a historical research and cross-sectional study, focused on arthropod fauna, situation of different arthropod borne diseases and also the ways which military personnel used to protect themselves against them. The information was adopted from valid military health files and also interviewing people who participated in the war.Results: Scabies, cutaneous leishmaniasis, sandfly fever and pediculosis were more prevalent among other arthropod -borne diseases in Iran-Iraq war. Measures to control arthropods and diseases at wartime mainly included: scheduled spraying of pesticides, leishmanization and treatment of patients.Conclusion: Although measures used during the war to control arthropods were proper, however, due to needs and importance of military forces to new equipment and technologies, it is recommended to use deltamethrin-impreg­nated bed net, permethrin treated military uniforms and various insect repellents in future.

  5. On Born's deformed reciprocal complex gravitational theory and noncommutative gravity

    International Nuclear Information System (INIS)

    Born's reciprocal relativity in flat spacetimes is based on the principle of a maximal speed limit (speed of light) and a maximal proper force (which is also compatible with a maximal and minimal length duality) and where coordinates and momenta are unified on a single footing. We extend Born's theory to the case of curved spacetimes and construct a deformed Born reciprocal general relativity theory in curved spacetimes (without the need to introduce star products) as a local gauge theory of the deformed Quaplectic group that is given by the semi-direct product of U(1,3) with the deformed (noncommutative) Weyl-Heisenberg group corresponding to noncommutative generators [Za,Zb]≠0. The Hermitian metric is complex-valued with symmetric and nonsymmetric components and there are two different complex-valued Hermitian Ricci tensors Rμν,Sμν. The deformed Born's reciprocal gravitational action linear in the Ricci scalars R,S with Torsion-squared terms and BF terms is presented. The plausible interpretation of Zμ=EμaZa as noncommuting p-brane background complex spacetime coordinates is discussed in the conclusion, where Eμa is the complex vielbein associated with the Hermitian metric Gμν=g(μν)+ig[μν]=EμaE-barνbηab. This could be one of the underlying reasons why string-theory involves gravity

  6. Transmission ecology of rodent-borne diseases: New frontiers.

    Science.gov (United States)

    Bordes, Frédéric; Blasdell, Kim; Morand, Serge

    2015-09-01

    Rodents are recognized reservoir hosts for many human zoonotic pathogens. The current trends resulting from anthropocene defaunation suggest that in the future they, along with other small mammals, are likely to become the dominant mammals in almost all human-modified environments. Recent intricate studies on bat-borne emerging diseases have highlighted that many gaps exist in our understanding of the zoonotic transmission of rodent-borne pathogens. This has emphasized the need for scientists interested in rodent-borne diseases to integrate rodent ecology into their analysis of rodent-borne pathogen transmission in order to identify in more detail the mechanisms of spillover and chains of transmission. Further studies are required to better understand the true impact of rodent abundance and the importance of pathogen sharing and circulation in multi-host- multi-pathogen communities. We also need to explore in more depth the roles of generalist and abundant species as the potential links between pathogen-sharing, co-infections and disease transmission. PMID:26176684

  7. The Well-Being of Children Born to Teen Mothers

    Science.gov (United States)

    Levine, Judith A.; Emery, Clifton R.; Pollack, Harold

    2007-01-01

    Children born to early child bearers are more likely than other children to display problem behaviors or poor academic performance, but it is unclear whether early childbearing plays a causal role in these outcomes. Using multiple techniques to control for background factors, we analyze 2,908 young children and 1,736 adolescents and young adults…

  8. Behavioral and social development of children born extremely premature

    DEFF Research Database (Denmark)

    Esbjørn, Barbara Hoff; Hansen, Bo Mølholm; Munck, Hanne; Mortensen, Erik Lykke

    2004-01-01

    A cohort of extremely prematurely born children and matched term controls was assessed at 5 years of age. The parents completed a questionnaire on their behavioral and social development. The purpose was to illuminate whether the children's general intellectual ability and parental sensitivity were...

  9. Tick-borne encephalitis virus in horses, Austria, 2011

    Czech Academy of Sciences Publication Activity Database

    Rushton, J. O.; Lecollinet, S.; Hubálek, Zdeněk; Svobodová, Petra; Lussy, H.; Nowotny, N.

    2013-01-01

    Roč. 19, č. 4 (2013), s. 635-637. ISSN 1080-6040 Institutional support: RVO:68081766 Keywords : tick-borne encephalitis virus (TBEV) * strains Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine Impact factor: 7.327, year: 2013

  10. Possible Tick-Borne Human Enterovirus Resulting in Aseptic Meningitis

    OpenAIRE

    Freundt, Eric C.; Beatty, Douglas C.; Stegall-Faulk, Teresa; Wright, Stephen M.

    2005-01-01

    Enterovirus-specific genetic sequences were isolated from two Amblyomma americanum tick pools. Identical genetic sequences were later obtained from cerebrospinal fluid of a patient with aseptic meningitis and a recent history of tick attachment. These observations suggest the possibility of an emerging tick-borne human enterovirus associated with aseptic meningitis.

  11. Towards a Supersymmetric Non-Abelian Born-Infeld Theory

    NARCIS (Netherlands)

    Bergshoeff, E.A.; Roo, M. de; Sevrin, A.

    2001-01-01

    We define an iterative procedure to obtain a non-abelian generalization of the Born-Infeld action. This construction is made possible by the use of the severe restrictions imposed by kappa-symmetry. We have calculated all bosonic terms in the action up to terms quartic in the Yang-Mills field streng

  12. Arthropod Borne Diseases in Imposed War during 1980-88

    Directory of Open Access Journals (Sweden)

    M Khoobdel

    2008-08-01

    Full Text Available Background: Personnel of military forces have close contact with natural habitat and usually encounter with bite of arthropods and prone to be infected with arthropod borne diseases. The imposed war against Iran was one of the most important and the longest war in the Middle East and even in the world and military people faced various diseases. The aim of this study was to review prevalence of arthropod borne diseases and to collect relevant information and valuable experiences during the imposed war. Methods: The present survey is a historical research and cross-sectional study, focused on arthropod fauna, situation of different arthropod borne diseases and also the ways which military personnel used to protect themselves against them. The information was adopted from valid military health files and also interviewing people who participated in the war. Results: Scabies, cutaneous leishmaniasis, sandfly fever and pediculosis were more prevalent among other arthropod -borne diseases in Iran-Iraq war. Measures to control arthropods and diseases at wartime mainly included: scheduled spraying of pesticides, leishmanization and treatment of patients. Conclusion: Although measures used during the war to control arthropods were proper, however, due to needs and importance of military forces to new equipment and technologies, it is recommended to use deltamethrin-impreg­nated bed net, permethrin treated military uniforms and various insect repellents in future.

  13. Balloon-borne gamma-ray telescope with nuclear emulsion

    OpenAIRE

    Takahashi, Satoru; Group, for the Emulsion Gamma-ray Telescope

    2010-01-01

    By detecting the beginning of electron pairs with nuclear emulsion, precise gamma-ray direction and gamma-ray polarization can be detected. With recent advancement in emulsion scanning system, emulsion analyzing capability is becoming powerful. Now we are developing the balloon-borne gamma-ray telescope with nuclear emulsion. Overview and status of our telescope is described.

  14. Photosensitized inactivation of infectious blood-borne human parasites

    Science.gov (United States)

    Judy, Millard M.; Sogandares-Bernal, Franklin M.; Matthews, James Lester

    1995-05-01

    Blood-borne viruses and protozoan parasites that are infectious to humans pose risk world-wide of infection transmission through blood and blood product transfusion. Blood-borne infectious viruses include human immunodeficiency virus (HIV-I), which causes AIDS; hepatitis C virus, which can cause chronic hepatitis; and cytomegalovirus, which can be dangerous to immunocompromised patients, e.g., the newborn, transplant recipients, and AIDS patients. Infectious blood-borne protozoan parasites include Trypanosoma cruzi, which causes Chagas' disease, endemic throughout Central and South America; the Trypanosoma species causing African sleeping sickness endemic in Central Africa; and Plasmodium falciparum, which causes malignant and increasingly drug- resistant human malaria prevalent throughout the tropics. Some researchers have focused on using photosensitizers to inactivate HIV-I and other viruses in whole blood, packed red cells, and platelet concentrates without compromising blood product function. Our group previously has reported photosensitized in vitro inactivation of P. falciparum and the mouse malaria organism Plasmodium berghei in whole blood using hematoporphyrin derivative (HPD) and of T. cruzi using benzoporphyrin derivatives BPDMA and BPDDA, dihematoporphyrin ether (DHE), and hydroxyethylvinyldeuteroporphyrin (HEVD). These results suggest that continued investigation is warranted to evaluate the potential for photosensitized inactivation of blood-borne parasites in blood banking.

  15. New England’s foreign-born population today

    OpenAIRE

    Ross Gittell; Timothy Lord

    2009-01-01

    Since the 1600s, immigrants have been drawn to New England, and even now parts of the region would be losing population and economic vitality if not for the foreign-born population. UNH’s Carsey Institute analyzes the demographics.

  16. Risk Factors for Retinopathy of Prematurity in Premature Born Children

    OpenAIRE

    Alajbegovic-Halimic, Jasmina; Zvizdic, Denisa; Alimanovic-Halilovic, Emina; Dodik, Irena; Duvnjak, Sanela

    2015-01-01

    Introduction: Retinopathy of Prematurity (ROP) represent disease of the eye in premature born children which affects immature blood vessels of the retina during their development. The emergence of retinopathy of prematurity depends on the interaction of multiple factors, such as: gestational age, low birth weight, hypoxia, duration of oxygen supplementation, respiratory distress syndrome, twin pregnancy, anemia, blood transfusions, sepsis, intraventricular hemorrhage, hypotension, hypothermia...

  17. Tick vaccines and the transmission of tick-borne pathogens.

    Science.gov (United States)

    de la Fuente, J; Kocan, K M; Blouin, E F

    2007-08-01

    Ticks transmit pathogens that cause diseases which greatly impact both human and animal health. Vaccines developed against Boophilus spp. using Bm86 and Bm95 tick gut antigens demonstrated the feasibility of using vaccines for control of tick infestations. These vaccines also reduced transmission of tick-borne pathogens by decreasing exposure of susceptible hosts to ticks. The recently discovered tick antigens, 64P putative cement protein and subolesin involved in the regulation of tick feeding and reproduction, were also shown to reduce tick infestations. These antigens, together with the TROSPA receptor for Burrelia burgdorferi OspA were effective against tick-borne pathogens by reducing the infection levels in ticks and/or the transmission of the pathogen. Development of a vaccine targeted at both the tick vector and pathogen would contribute greatly to the control of tick infestations and the transmission of tick-borne diseases. These results have demonstrated that tick vaccines can be developed for control tick infestations and show promise for the prevention of the transmission of tick-borne pathogens. PMID:17682852

  18. Seed borne diseases - a challenge for organic cereal production

    OpenAIRE

    Borgen, Anders; Kristensen, Lars,

    2000-01-01

    Seed borne diseases are to be considered serious in organic agriculture, and direct seed treatment methods will some times be necessary. Hot water treatment, mustard extracts and acetic acid can provide efficient control methods. Discussions on the feasibility of the different methods in organic agriculture is needed.

  19. Impact of climate variability on vector-borne disease transmission

    Science.gov (United States)

    We will discuss the impact of climate variability on vector borne diseases and demonstrate that global climate teleconnections can be used to anticipate and forecast, in the case of Rift Valley fever, epidemics and epizootics. In this context we will examine significant worldwide weather anomalies t...

  20. COMMUNITY LEVEL ANALYSIS OF VECTOR-BORNE DISEASE

    Science.gov (United States)

    Ecological community structure is particularly important in vector-borne zoonotic diseases with complex life cycles. Single population models, such as the so-called Ross-Macdonald model (Baily, 1982), have been important in developing and characterizing our current understanding...

  1. The Alliance Capability of Technology-Based Born Globals

    DEFF Research Database (Denmark)

    Oxtorp, Liliya Altshuler; Elg, Ulf

    2015-01-01

    organisational skills that enable the firms to successfully initiate, manage and finish their R&D alliances with MNEs. The in-depth longitudinal methodology adds insight and value to the study. It is discussed how the specific aspects of the alliance capability can help born globals to counteract the challenges...

  2. Lovelock gravities from Born-Infeld gravity theory

    CERN Document Server

    Concha, P K; Rodríguez, E K

    2016-01-01

    We present a Born-Infeld gravity theory based on generalizations of Maxwell symmetries denoted as $\\mathfrak{C}_{m}$. We analyze different configuration limits allowing to recover diverse Lovelock gravity actions in six dimensions. Further, the generalization to higher even dimensions is also considered.

  3. Acrylic polymer nanocomposite resins for water borne coating applications

    NARCIS (Netherlands)

    Nobel, M.L.

    2007-01-01

    Due to environmental and safety regulations the use of volatile organic components (VOC's) containing lacquers for exterior automotive purposes is under growing pressure. As a consequence there is a demand for more environmentally friendly alternatives like water borne coatings, high solid coatings,

  4. Soliton solutions of Chiral Born-Infeld Theory and baryons

    OpenAIRE

    Pavlovsky, Oleg V.

    2003-01-01

    Finite-energy topological spherically symmetrical solutions of Chiral Born-Infeld Theory are studied. Properties of these solution are obtained, and a possible physical interpretation is also given. We compute static properties of baryons (mass,main radius, magnetic main radius, axial coupling constant) whose solutions can be interpreted as the baryons of QCD.

  5. Born-Oppenheimer approximation for a harmonic molecule

    OpenAIRE

    Fernandez, Francisco M.

    2008-01-01

    We apply the Born-Oppenheimer approximation to a harmonic diatomic molecule with one electron. We compare the exact and approximate results not only for the internal degrees of freedom but also for the motion of the center of mass. We address the problem of identical nuclei and discuss other applications of the model and its limitations.

  6. Bacterial food-borne pathogens in Indian food

    International Nuclear Information System (INIS)

    Food technology and food processing techniques have made tremendous advances in preservation of food and ensuring safety of food by killing food-borne pathogens. In addition to old techniques such as pasteurization, canning, dehydration, fermentation and salting, a number of new techniques such as radiation processing, high pressure technology and pulsed electric field technology are being applied for preservation of food and to ensure food safety. Total Quality Management (TQM) concepts have been developed to take care of food safety from farm to table. Hazard Analysis at Critical Control Points (HACCP) is being applied for mass scale production of food to make food free from pathogens. Despite these advances, food-borne diseases have become one of the most widespread public health problems in the world. About two thirds of all the outbreaks are traced to microbial contaminated food. According to World Health Organization (WHO) estimates, food-borne and waterborne diarrhoeal diseases kill an estimated 2 million people annually, including many children. Food safety is a major concern not only for developing countries but also for the developed countries. A number of factors such as emergence of new food-borne pathogens, development of drug resistance in pathogens, changing life style, globalization of the food supply etc. are responsible for the continuous persistence of food-borne diseases. The food-borne disease outbreaks due to E. coli O157:H7, Listeria monocytogenes, Salmonella and Campylobacter, are responsible for recall of many foods resulting in heavy losses to food industry. Due to consumer demand, a number of Ready-To-Eat (RTE) minimally processed foods are increasingly marketed; however, there is increased risk of foodborne diseases with these products. Food Technology Division of Bhabha Atomic Research Centre, Mumbai, has been working on food-borne bacterial pathogens particularly Salmonella, Campylobacter, Listeria monocytogenes, Vibrio and Aeromonasf

  7. Practical solutions to implementing "Born Semantic" data systems

    Science.gov (United States)

    Leadbetter, A.; Buck, J. J. H.; Stacey, P.

    2015-12-01

    The concept of data being "Born Semantic" has been proposed in recent years as a Semantic Web analogue to the idea of data being "born digital"[1], [2]. Within the "Born Semantic" concept, data are captured digitally and at a point close to the time of creation are annotated with markup terms from semantic web resources (controlled vocabularies, thesauri or ontologies). This allows heterogeneous data to be more easily ingested and amalgamated in near real-time due to the standards compliant annotation of the data. In taking the "Born Semantic" proposal from concept to operation, a number of difficulties have been encountered. For example, although there are recognised methods such as Header, Dictionary, Triples [3] for the compression, publication and dissemination of large volumes of triples these systems are not practical to deploy in the field on low-powered (both electrically and computationally) devices. Similarly, it is not practical for instruments to output fully formed semantically annotated data files if they are designed to be plugged into a modular system and the data to be centrally logged in the field as is the case on Argo floats and oceanographic gliders where internal bandwidth becomes an issue [2]. In light of these issues, this presentation will concentrate on pragmatic solutions being developed to the problem of generating Linked Data in near real-time systems. Specific examples from the European Commission SenseOCEAN project where Linked Data systems are being developed for autonomous underwater platforms, and from work being undertaken in the streaming of data from the Irish Galway Bay Cable Observatory initiative will be highlighted. Further, developments of a set of tools for the LogStash-ElasticSearch software ecosystem to allow the storing and retrieval of Linked Data will be introduced. References[1] A. Leadbetter & J. Fredericks, We have "born digital" - now what about "born semantic"?, European Geophysical Union General Assembly, 2014

  8. Saturated Zone Colloid Transport

    International Nuclear Information System (INIS)

    This scientific analysis provides retardation factors for colloids transporting in the saturated zone (SZ) and the unsaturated zone (UZ). These retardation factors represent the reversible chemical and physical filtration of colloids in the SZ. The value of the colloid retardation factor, Rcol is dependent on several factors, such as colloid size, colloid type, and geochemical conditions (e.g., pH, Eh, and ionic strength). These factors are folded into the distributions of Rcol that have been developed from field and experimental data collected under varying geochemical conditions with different colloid types and sizes. Attachment rate constants, katt, and detachment rate constants, kdet, of colloids to the fracture surface have been measured for the fractured volcanics, and separate Rcol uncertainty distributions have been developed for attachment and detachment to clastic material and mineral grains in the alluvium. Radionuclides such as plutonium and americium sorb mostly (90 to 99 percent) irreversibly to colloids (BSC 2004 [DIRS 170025], Section 6.3.3.2). The colloid retardation factors developed in this analysis are needed to simulate the transport of radionuclides that are irreversibly sorbed onto colloids; this transport is discussed in the model report ''Site-Scale Saturated Zone Transport'' (BSC 2004 [DIRS 170036]). Although it is not exclusive to any particular radionuclide release scenario, this scientific analysis especially addresses those scenarios pertaining to evidence from waste-degradation experiments, which indicate that plutonium and americium may be irreversibly attached to colloids for the time scales of interest. A section of this report will also discuss the validity of using microspheres as analogs to colloids in some of the lab and field experiments used to obtain the colloid retardation factors. In addition, a small fraction of colloids travels with the groundwater without any significant retardation. Radionuclides irreversibly sorbed

  9. Parapapillary atrophy: histological gamma zone and delta zone.

    Directory of Open Access Journals (Sweden)

    Jost B Jonas

    Full Text Available BACKGROUND: To examine histomorphometrically the parapapillary region in human eyes. METHODOLOGY/PRINCIPAL FINDINGS: The histomorphometric study included 65 human globes (axial length:21-37 mm. On anterior-posterior histological sections, we measured the distance Bruch's membrane end (BME-optic nerve margin ("Gamma zone", BME-retinal pigment epithelium (RPE ("Beta zone", BME-beginning of non-occluded choriocapillaris, and BME-beginning of photoreceptor layer. "Delta zone" was defined as part of gamma zone in which blood vessels of at least 50 µm diameter were not present over a length of >300 µm. Beta zone (mean length:0.35±0.52 mm was significantly (P = 0.01 larger in the glaucoma group than in the non-glaucomatous group. It was not significantly (P = 0.28 associated with axial length. Beta zone was significantly (P = 0.004 larger than the region with occluded choriocapillaris. Gamma zone (mean length:0.63±1.25 mm was associated with axial length (P50 µm diameter within gamma zone was present only in highly axially elongated globes and was not related with glaucoma. Beta zone (Bruch's membrane without RPE was correlated with glaucoma but not with globe elongation. Since the region with occluded choriocapillaris was smaller than beta zone, complete loss of RPE may have occurred before complete choriocapillaris closure.

  10. DNA microarray technique for detecting food-borne pathogens

    Directory of Open Access Journals (Sweden)

    Xing GAO

    2012-08-01

    Full Text Available Objective To study the application of DNA microarray technique for screening and identifying multiple food-borne pathogens. Methods The oligonucleotide probes were designed by Clustal X and Oligo 6.0 at the conserved regions of specific genes of multiple food-borne pathogens, and then were validated by bioinformatic analyses. The 5' end of each probe was modified by amino-group and 10 Poly-T, and the optimized probes were synthesized and spotted on aldehyde-coated slides. The bacteria DNA template incubated with Klenow enzyme was amplified by arbitrarily primed PCR, and PCR products incorporated into Aminoallyl-dUTP were coupled with fluorescent dye. After hybridization of the purified PCR products with DNA microarray, the hybridization image and fluorescence intensity analysis was acquired by ScanArray and GenePix Pro 5.1 software. A series of detection conditions such as arbitrarily primed PCR and microarray hybridization were optimized. The specificity of this approach was evaluated by 16 different bacteria DNA, and the sensitivity and reproducibility were verified by 4 food-borne pathogens DNA. The samples of multiple bacteria DNA and simulated water samples of Shigella dysenteriae were detected. Results Nine different food-borne bacteria were successfully discriminated under the same condition. The sensitivity of genomic DNA was 102 -103pg/ μl, and the coefficient of variation (CV of the reproducibility of assay was less than 15%. The corresponding specific hybridization maps of the multiple bacteria DNA samples were obtained, and the detection limit of simulated water sample of Shigella dysenteriae was 3.54×105cfu/ml. Conclusions The DNA microarray detection system based on arbitrarily primed PCR can be employed for effective detection of multiple food-borne pathogens, and this assay may offer a new method for high-throughput platform for detecting bacteria.

  11. Tick-borne encephalitis virus infection in humans

    Directory of Open Access Journals (Sweden)

    Hrnjaković-Cvjetković Ivana

    2016-01-01

    Full Text Available Introduction. Tick-borne meningoencephalitis virus is a flavivirus that causes the most important vector-borne central nervous system infection in many countries of Europe and Asia. There are three subtypes of tick-borne encephalitis virus: European, Siberian and the Far-Eastern subtype. Transmission. In endemic areas, the virus remains in transmissive cycles between Ixodes ticks and small rodents. Clinical picture. In most cases (70−98% infection goes asymptomatically. In about one-third of meningitis cases, meningoencephalitis or meningomyelitis is developed. Postencephalytic syndrome may be the complication of the infection, presenting with neurological symptoms. Diagnosis. Etiologic diagnosis of tick-borne meningoencephalitis is only made on basis of laboratory analyses. Reverse transcription-polymerase chain reaction is used for determining the presence of virus in the blood and cerebrospinal fluid. Antibodies in blood and cerebrospinal fluid can be detected by serological tests. Prevention. The most efficient way to control this potentially severe disease with possible serious long-term consequences is vaccination. It should be recommended to persons who live or travel to endemic areas. Conclusion. In Serbia, tick-borne encephalitis virus infection belongs to the list of reportable diseases; however, there are no reported cases because the diagnostics is not performed routinely. We believe that the significance of this zoonosis must be examined in our country and some of its parts because of preliminary positive serological findings found out in Vojvodina as well as because of reported cases in neighboring countries such as Hungary and Croatia and its worldwide distribution.

  12. The Near Zone to Far Zone Transformation (N2F)

    Energy Technology Data Exchange (ETDEWEB)

    Blackfield, Donald T. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Poole, Brian R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-03-11

    N2F is a C/C++ code used to calculate the far zone electromagnetic (EM) field, given E and H near zone field data. The method used by N2F can be found in Ref. 1 and 2. N2F determines the far field EΦ and Eθ in spherical coordinates for near zone data calculated in either Cartesian or Cylindrical geometry.

  13. NOVEL ZONING RULE FOR DESIGNING SQUARE FRESNEL ZONE PLATE

    OpenAIRE

    Minin, I.; Minin, O.; Petosa, A.; Thirakoune, S.

    2006-01-01

    An improved zoning rule is presented for designing a square Fresnel zone plate lens (FZPL). This new rule results in a higher gain when the FZPL is used as an antenna element or can enhance the focusing properties of the square FZPL when used to collimate an incident plane wave. The derivation of this improved zoning rule is presented along with simulated results for some typical cases.

  14. International Network for Capacity Building for the Control of Emerging Viral Vector-Borne Zoonotic Diseases: Arbo-Zoonet

    NARCIS (Netherlands)

    Ahmed, J.; Bouloy, M.; Ergonul, O.; Fooks, A.R.; Paweska, J.; Chevalier, V.; Drosten, C.; Moormann, R.J.M.; Tordo, N.; Vatansever, Z.; Calistri, P.; Estrada-Pena, A.; Mirazimi, A.; Unger, H.; Yin, H.; Seitzer, U.

    2009-01-01

    Arboviruses are arthropod-borne viruses, which include West Nile fever virus (WNFV), a mosquito-borne virus, Rift Valley fever virus (RVFV), a mosquito-borne virus, and Crimean-Congo haemorrhagic fever virus (CCHFV), a tick-borne virus. These arthropod-borne viruses can cause disease in different do

  15. Empowerment Zones and Enterprise Districts - Volusia County Enterprise Zones

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — Florida's Enterprise Zone Program encourages economic growth and investment in distressed areas by offering tax advantages and incentives to businesses that are...

  16. Nairu en zone heureuse

    OpenAIRE

    Reynès, Frédéric; Lemoine, Matthieu; Veroni, Paola

    2007-01-01

    Cette étude spéciale propose des estimations du niveau non inflationniste du taux de chômage (Nairu) pour la zone euro agrégée, pour la France, l’Italie et l’Allemagne. Une équation d’inflation, qui dépend de l’écart du taux de chômage au Nairu, est estimée par le filtre de Kalman. Le modèle le plus simple, qui considère le Nairu comme une marche aléatoire, a des capacités prédictives limitées. Il diagnostique un taux de chômage inférieur au Nairu à l’horizon de notre prévision. Il est con...

  17. The zone of alienation

    International Nuclear Information System (INIS)

    Ten years after the nuclear disaster, people still live and die in Chernobyl. Thousands of people continue to live and work there. Roughly 500 have moved back into their old homes inside the alienation zone. Fewer than half still alive. Medical researchers in the area insist that immune systems are weakened by doses of radiation far lower than previously thought. However, an European Union sponsored study concluded that Chernobyl's toll has been exaggerated. Thus, while 760 children in the contaminated area have developed thyroid cancer, only three have died as a result. Yet in and around Chernobyl, people carry on their lives and the Ukrainian Government says it can't afford to close the plant without billions of dollars in Western aid. ills

  18. Saturated Zone Colloid Transport

    Energy Technology Data Exchange (ETDEWEB)

    H. S. Viswanathan

    2004-10-07

    This scientific analysis provides retardation factors for colloids transporting in the saturated zone (SZ) and the unsaturated zone (UZ). These retardation factors represent the reversible chemical and physical filtration of colloids in the SZ. The value of the colloid retardation factor, R{sub col} is dependent on several factors, such as colloid size, colloid type, and geochemical conditions (e.g., pH, Eh, and ionic strength). These factors are folded into the distributions of R{sub col} that have been developed from field and experimental data collected under varying geochemical conditions with different colloid types and sizes. Attachment rate constants, k{sub att}, and detachment rate constants, k{sub det}, of colloids to the fracture surface have been measured for the fractured volcanics, and separate R{sub col} uncertainty distributions have been developed for attachment and detachment to clastic material and mineral grains in the alluvium. Radionuclides such as plutonium and americium sorb mostly (90 to 99 percent) irreversibly to colloids (BSC 2004 [DIRS 170025], Section 6.3.3.2). The colloid retardation factors developed in this analysis are needed to simulate the transport of radionuclides that are irreversibly sorbed onto colloids; this transport is discussed in the model report ''Site-Scale Saturated Zone Transport'' (BSC 2004 [DIRS 170036]). Although it is not exclusive to any particular radionuclide release scenario, this scientific analysis especially addresses those scenarios pertaining to evidence from waste-degradation experiments, which indicate that plutonium and americium may be irreversibly attached to colloids for the time scales of interest. A section of this report will also discuss the validity of using microspheres as analogs to colloids in some of the lab and field experiments used to obtain the colloid retardation factors. In addition, a small fraction of colloids travels with the groundwater without any significant

  19. Speech and oromotor outcome in adolescents born preterm: relationship to motor tract integrity.

    OpenAIRE

    Northam, G. B.; Liégeois, F.; Chong, W.K.; Baker, K; Tournier, J. D.; Wyatt, J. S.; Baldeweg, T; Morgan, A.

    2012-01-01

    Objective To assess speech abilities in adolescents born preterm and investigate whether there is an association between specific speech deficits and brain abnormalities. Study design Fifty adolescents born prematurely (

  20. Block the Buzzing, Bites, and Bumps: Preventing Mosquito-Borne Illnesses

    Science.gov (United States)

    ... Subscribe Block the Buzzing, Bites, and Bumps Preventing Mosquito-Borne Illnesses Summer can be a bummer if ... find better ways to diagnose, treat, and prevent mosquito-borne illnesses. And we can all take simple ...

  1. Large baby syndrome in singletons born after frozen embryo transfer (FET)

    DEFF Research Database (Denmark)

    Pinborg, Anja; Henningsen, AA; Loft, A;

    2013-01-01

    Are singletons born after frozen embryo transfer (FET) at increased risk of being born large for gestational age (LGA) and if so, is this caused by intrinsic maternal factors or related to the freezing/thawing procedures?...

  2. Contaminants in Vadose Zone Environments

    Energy Technology Data Exchange (ETDEWEB)

    Wellman, Dawn M.; Freshley, Mark D.; Johnson, Timothy C.; Miracle, Ann L.

    2012-11-01

    Contaminants in vadose zone environments pose a long-term source and threat to groundwater resources, human health, and the environment. Several technical, regulatory, and policy challenges and opportunities are associated with contamination in vadose zone environments, particularly in remediation. In this special issue, ten papers present novel approaches to characterize, monitor, remediate, and predict the transport and fate of contaminants in vadose zone environments.

  3. Learning About Intervention Target Zones

    OpenAIRE

    Michael W. Klein; Karen K. Lewis

    1991-01-01

    This paper provides a framework for evaluating how market participants' beliefs about foreign exchange target zones change as they learn about central bank intervention policy. In order to examine this behavior, we first generalize the standard target zone model to allow for intra-marginal intervention. Intra-marginal intervention implies that the position of market participants' beliefs about the target zone can be determined from their beliefs about the likelihood of intervention. As an app...

  4. Street Prostitution Zones and Crime

    OpenAIRE

    Bisschop, Paul; Kastoryano, Stephen; Van der Klaauw, Bas

    2015-01-01

    This paper studies the effects of introducing legal street prostitution zones on both registered and perceived crime. We exploit a unique setting in the Netherlands where legal street prostitution zones were opened in nine cities under different regulation systems. We provide evidence that the opening of these zones was not in response to changes in crime. Our difference-in-difference analysis using data on the largest 25 Dutch cities between 1994 and 2011 shows that opening a legal street pr...

  5. Race, Ethnicity, and Discriminatory Zoning

    OpenAIRE

    Allison Shertzer; Tate Twinam; Randall P. Walsh

    2014-01-01

    Zoning has been cited as a discriminatory policy tool by critics, who argue that ordinances are used to deter the entry of minority residents into majority neighborhoods through density restrictions (exclusionary zoning) and locate manufacturing activity in minority neighborhoods (environmental racism). However, identifying discrimination in these regulations is complicated by the fact that land use and zoning have been co-evolving for nearly a century in most American cities, rendering resid...

  6. Problems of Chernobyl Exclusion Zone

    International Nuclear Information System (INIS)

    The collection comprises the results of researches and design activity in the ChNPP exclusion zone, aimed at the development of technologies, equipment and devices for radioactive waste management and ChNPP accident clean-up, at studying the composition and structure of the Exclusion zone soil activity solid bearers, form transformation of the fission products of fuel fallout radionuclide composition in the ChNPP near zone, the spatial distribution of radionuclides and other radioecological issues.. Much attention is paid to medical and biological aspects of the accident influence on the flora, fauna and people's health, labour conditions and incidence of the workers of the Exclusion zone

  7. Coulomb-Born-Oppenheimer approximation in Ps-H scattering

    Indian Academy of Sciences (India)

    Hasi Ray

    2006-02-01

    To improve the Coulomb-Born approximation (CBA) theory of ionization in positronium (Ps) and atom scattering, the effect of exchange is introduced. The nine-dimensional exchange amplitude for ionization of Ps in Ps-H scattering is reduced to a two-dimensional integral using the present Coulomb-Born-Oppenheimer approximation (CBOA). The methodology is extremely useful to evaluate ionization parameters for different target systems and for different types of ionization processes. It is then applied to evaluate the Ps-ionization cross-section and to estimate the effect of exchange on Ps-ionization in Ps-H system. We establish the importance of exchange at lower energy region.

  8. Anxiety in adolescents born preterm or with very low birthweight

    DEFF Research Database (Denmark)

    Sømhovd, Mikael Julius; Hansen, Bo Mølholm; Brok, Jesper Sune;

    2012-01-01

    , and full articles identified through the searches. Subsequently two authors independently extracted data. Results We included six studies with 1519 adolescents (787 very preterm/VLBW, 732 comparisons). The general risk of developing clinically significant anxiety problems was nearly doubled (p<0......Aim To determine if adolescents who are born very preterm (<32wks; of gestation) and/or with very low birthweight (VLBW; <1500g) have a higher risk of experiencing clinically significant anxiety problems. Method We used a systematic review and meta-analysis. We searched the databases ISI Web of...... identified articles. We selected casecontrol studies of adolescents 11 to 20 years old who were very preterm/VLBW and had a matched reference group born at term with normal birthweight that reported a validated anxiety outcome measure. For data extraction, two authors independently reviewed titles, abstracts...

  9. A shock absorber model for structure-borne noise analyses

    Science.gov (United States)

    Benaziz, Marouane; Nacivet, Samuel; Thouverez, Fabrice

    2015-08-01

    Shock absorbers are often responsible for undesirable structure-borne noise in cars. The early numerical prediction of this noise in the automobile development process can save time and money and yet remains a challenge for industry. In this paper, a new approach to predicting shock absorber structure-borne noise is proposed; it consists in modelling the shock absorber and including the main nonlinear phenomena responsible for discontinuities in the response. The model set forth herein features: compressible fluid behaviour, nonlinear flow rate-pressure relations, valve mechanical equations and rubber mounts. The piston, base valve and complete shock absorber model are compared with experimental results. Sensitivity of the shock absorber response is evaluated and the most important parameters are classified. The response envelope is also computed. This shock absorber model is able to accurately reproduce local nonlinear phenomena and improves our state of knowledge on potential noise sources within the shock absorber.

  10. A differential equation for the Generalized Born radii.

    Science.gov (United States)

    Fogolari, Federico; Corazza, Alessandra; Esposito, Gennaro

    2013-06-28

    The Generalized Born (GB) model offers a convenient way of representing electrostatics in complex macromolecules like proteins or nucleic acids. The computation of atomic GB radii is currently performed by different non-local approaches involving volume or surface integrals. Here we obtain a non-linear second-order partial differential equation for the Generalized Born radius, which may be solved using local iterative algorithms. The equation is derived under the assumption that the usual GB approximation to the reaction field obeys Laplace's equation. The equation admits as particular solutions the correct GB radii for the sphere and the plane. The tests performed on a set of 55 different proteins show an overall agreement with other reference GB models and "perfect" Poisson-Boltzmann based values. PMID:23676843

  11. Rationale for wind-borne missile criteria for DOE facilities

    Energy Technology Data Exchange (ETDEWEB)

    McDonald, J R; Murray, R

    1999-09-01

    High winds tend to pick up and transport various objects and debris, which are referred to as wind-borne missiles or tornado missiles, depending on the type of storm. Missiles cause damage by perforating the building envelope or by collapsing structural elements such as walls, columns or frames. The primary objectives of this study are as follows: (1) to provide a basis for wind-borne or tornado missile criteria for the design and evaluation of DOE facilities, and (2) to provide guidelines for the design and evaluation of impact-resistant missile barriers for DOE facilities The first objective is accomplished through a synthesis of information from windstorm damage documentation experience and computer simulation of missile trajectories. The second objective is accomplished by reviewing the literature, which describes various missile impact tests, and by conducting a series of impact tests at a Texas Tech University facility to fill in missing information.

  12. Tick-borne lymphadenopathy (TIBOLA acquired in Southwestern Germany

    Directory of Open Access Journals (Sweden)

    Wölfel Silke

    2011-06-01

    Full Text Available Abstract Background Tick-borne lymphadenopathy (TIBOLA was first described in 1997 in a patient in France. The causative agent, Rickettsia slovaca, is transmitted by Dermacentor ticks. Case presentation In southwestern Germany we encountered a patient with a tick bite at the dorsal scalp that resulted in an eschar and nuchal lymphadenopathy. Additionally, fever, malaise as well as elevated inflammatory markers and transaminases occurred. The characteristic clinical picture along with positive antibody testing for rickettsiae of the tick-borne spotted fever group strongly suggest the diagnosis TIBOLA. Conclusion Human rickettsioses are emerging infections. Clinicians should be aware of TIBOLA as a newly described rickettsial disease. As in our case, TIBOLA may be encountered in regions/countries where R. slovaca and Dermacentor ticks are prevalent but autochthonous acquisition was not described before.

  13. Topological vortices in generalized Born-Infeld-Higgs electrodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Casana, R. [Universidade Federal do Maranhao, Departamento de Fisica, Sao Luis, Maranhao (Brazil); Hora, E. da [Universidade Federal do Maranhao, Departamento de Fisica, Sao Luis, Maranhao (Brazil); Universidade Federal do Maranhao, Coordenadoria Interdisciplinar de Ciencia e Tecnologia, Sao Luis, Maranhao (Brazil); Rubiera-Garcia, D. [Fudan University, Department of Physics, Center for Field Theory and Particle Physics, Shanghai (China); Santos, C. dos [Faculdade de Ciencias da Universidade do Porto, Centro de Fisica e Departamento de Fisica e Astronomia, Porto (Portugal)

    2015-08-15

    A consistent BPS formalism to study the existence of topological axially symmetric vortices in generalized versions of the Born-Infeld-Higgs electrodynamics is implemented. Such a generalization modifies the field dynamics via the introduction of three nonnegative functions depending only in the Higgs field, namely,G(vertical stroke φ vertical stroke), w(vertical stroke φ vertical stroke), and V (vertical stroke φ vertical stroke). A set of first-order differential equations is attained when these functions satisfy a constraint related to the Ampere law. Such a constraint allows one to minimize the system's energy in such way that it becomes proportional to the magnetic flux. Our results provides an enhancement of the role of topological vortex solutions in Born-Infeld-Higgs electrodynamics. Finally, we analyze a set of models entailing the recovery of a generalized version of Maxwell-Higgs electrodynamics in a certain limit of the theory. (orig.)

  14. Two-Field Born-Infeld with Diverse Dualities

    CERN Document Server

    Ferrara, S; Yeranyan, A

    2016-01-01

    We elaborate on how to build, in a systematic fashion, two-field Abelian extensions of the Born-Infeld Lagrangian. These models realize the non-trivial duality groups that are allowed in this case, namely U(2), SU(2) and U(1)xU(1). For each class, we also construct an explicit example. They all involve an overall square root and reduce to the Born-Infeld model if the two fields are identified, but differ in quartic and higher interactions. The U(1)xU(1) and SU(2) examples recover some recent results obtained with different techniques, and we show that the U(1)xU(1) model admits an N=1 supersymmetric completion. The U(2) example includes some unusual terms that are not analytic at the origin of field space.

  15. Analysis of the Time Reversible Born-Oppenheimer Molecular Dynamics

    CERN Document Server

    Lin, Lin; Shao, Sihong

    2013-01-01

    We analyze the time reversible Born-Oppenheimer molecular dynamics (TRBOMD) scheme, which preserves the time reversibility of the Born-Oppenheimer molecular dynamics even with non-convergent self-consistent field iteration. In the linear response regime, we derive the stability condition as well as the accuracy of TRBOMD for computing physical properties such as the phonon frequency obtained from the molecular dynamic simulation. We connect and compare TRBOMD with the Car-Parrinello molecular dynamics in terms of accuracy and stability. We further discuss the accuracy of TRBOMD beyond the linear response regime for non-equilibrium dynamics of nuclei. Our results are demonstrated through numerical experiments using a simplified one dimensional model for Kohn-Sham density functional theory.

  16. Electronic Flux Density beyond the Born-Oppenheimer Approximation.

    Science.gov (United States)

    Schild, Axel; Agostini, Federica; Gross, E K U

    2016-05-19

    In the Born-Oppenheimer approximation, the electronic wave function is typically real-valued and hence the electronic flux density (current density) seems to vanish. This is unfortunate for chemistry, because it precludes the possibility to monitor the electronic motion associated with the nuclear motion during chemical rearrangements from a Born-Oppenheimer simulation of the process. We study an electronic flux density obtained from a correction to the electronic wave function. This correction is derived via nuclear velocity perturbation theory applied in the framework of the exact factorization of electrons and nuclei. To compute the correction, only the ground state potential energy surface and the electronic wave function are needed. For a model system, we demonstrate that this electronic flux density approximates the true one very well, for coherent tunneling dynamics as well as for over-the-barrier scattering, and already for mass ratios between electrons and nuclei that are much larger than the true mass ratios. PMID:26878256

  17. Weak Measurements, Quantum State Collapse and the Born Rule

    CERN Document Server

    Patel, Apoorva

    2015-01-01

    Projective measurement is used as a fundamental axiom in quantum mechanics, even though it is discontinuous and cannot predict which measured operator eigenstate will be observed in which experimental run. The probabilistic Born rule gives it an ensemble interpretation, predicting proportions of various outcomes over many experimental runs. Understanding gradual weak measurements requires replacing this scenario with a dynamical evolution equation for the collapse of the quantum state in individual experimental runs. We propose such an equation, which combines attraction towards the measured operator eigenstates with stochastic white noise, and for a specific ratio of the two reproduces the Born rule. The irreducible measurement noise then becomes a fundamental property of quantum mechanics, and a necessary ingredient for any attempt to generate quantum mechanics from an underlying theory.

  18. Analysis of Time Reversible Born-Oppenheimer Molecular Dynamics

    Directory of Open Access Journals (Sweden)

    Lin Lin

    2013-12-01

    Full Text Available We analyze the time reversible Born-Oppenheimer molecular dynamics (TRBOMD scheme, which preserves the time reversibility of the Born-Oppenheimer molecular dynamics even with non-convergent self-consistent field iteration. In the linear response regime, we derive the stability condition, as well as the accuracy of TRBOMD for computing physical properties, such as the phonon frequency obtained from the molecular dynamics simulation. We connect and compare TRBOMD with Car-Parrinello molecular dynamics in terms of accuracy and stability. We further discuss the accuracy of TRBOMD beyond the linear response regime for non-equilibrium dynamics of nuclei. Our results are demonstrated through numerical experiments using a simplified one-dimensional model for Kohn-Sham density functional theory.

  19. Born-Infeld electrodynamics in very special relativity

    CERN Document Server

    Bufalo, R

    2015-01-01

    In this work we discuss the properties of a modified Born-Infeld electrodynamics in the framework of very special relativity (VSR). This proposal allows us to study VSR mass effects in a gauge-invariant context of nonlinear electrodynamics. It is analyzed in detail the electrostatic solutions for two different cases, as well as the VSR dispersion relations are found to be of a \\emph{massive} particle with nonlinear modifications. Afterwards, the field energy and static potential are computed, in the latter we find from the VSR contribution a novel long-range $1/L^3$ correction to the Coulomb potential, in contrast to the $1/L^5$ correction of the usual Born-Infeld theory.

  20. Global from the Start: The Characteristics of Born-Global Firms in the Technology Sector

    OpenAIRE

    Stoyan Tanev

    2012-01-01

    This article provides insights from recent research on firms that are "born global". A born-global firm is a venture launched to exploit a global niche from the first day of its operations. The insights in this article are relevant to technology entrepreneurs and top management teams of new technology firms. After discussing various definitions for the term "born global" and identifying the main characteristics of born-global firms, this article lists a few salient characteristics of firms th...

  1. County Differences in Mortality among Foreign-Born Compared to Native Swedes 1970-1999

    OpenAIRE

    Björn Albin; Katarina Hjelm; Jan Ekberg; Sölve Elmståhl

    2012-01-01

    Background. Regional variations in mortality and morbidity have been shown in Europe and USA. Longitudinal studies have found increased mortality, dissimilarities in mortality pattern, and differences in utilization of healthcare between foreign- and native-born Swedes. No study has been found comparing mortality among foreign-born and native-born Swedes in relation to catchment areas/counties. Methods. The aim was to describe and compare mortality among foreign-born persons and native Swedes...

  2. Cosmological constraints for an Eddington-Born-Infeld field

    CERN Document Server

    De Felice, Antonio; Jhingan, Sanjay

    2012-01-01

    We consider the Eddington-Born-Infeld (EBI) model here without assuming any cosmological constant. The EBI scalar field is supposed to play a role of both dark matter and dark energy. Different eras in cosmology are reconstructed for the model. A comparison is drawn with $\\Lambda$CDM model using Supernova Ia, WMAP7 and BAO data. It seems that the EBI field in this form does not give good fit to observational data in comparison to the $\\Lambda$CDM model.

  3. What About Quantum Theory? Bayes and the Born Interpretation

    OpenAIRE

    Tipler, Frank J.

    2006-01-01

    I show that probabilities in quantum mechanics are a measure of belief in the presence of human ignorance, just like all other probabilities. The Born interpretation of the square of modulus of the wave function arises from the interaction of a quantum system with an observer, and probabilities will not arise unless the observer is unable to access all the information available in the system's wave function. Quantum mechanics generally does not permit all the information to be obtained, even ...

  4. Food-borne bacteremic illnesses in febrile neutropenic children

    OpenAIRE

    Anselm Chi-wai Lee; Nellie Dawn Siao-ping Ong

    2011-01-01

    Bacteremia following febrile neutropenia is a serious complication in children with malignancies. Preventive measures are currently targeted at antimicrobial prophylaxis, amelioration of drug-induced neutropenia, and nosocomial spread of pathogens, with little attention to community-acquired infections. A retrospective study was conducted at a pediatric oncology center during a 3-year period to identify probable cases of food-borne infections with bacteremia. Twenty-one bacteremic illnesses a...

  5. Epidemiology of tick-borne borreliosis in Morocco

    OpenAIRE

    Diatta, Georges; Souidi, Yassine; Granjon, Laurent; Arnathau, Céline; Durand, Patrick; Chauvancy, Gilles; Mané, Youssouph; Sarih, M'Hammed; BELGHYTI, Driss; Renaud, François; Trape, Jean-François

    2012-01-01

    Background: The presence in Morocco of Argasid ticks of the Ornithodoros erraticus complex, the vector of tick-borne relapsing fever (TBRF) in North Africa, has been known since 1919, but the disease is rarely diagnosed and few epidemiological data are available. Methodology/Principal Findings: Between 2006 and 2011, we investigated the presence of Ornithodoros ticks in rodent burrows in 34 sites distributed across Morocco. We also collected small mammals in 10 sites and we investigated TBRF ...

  6. Innovation, organizational capabilities, and the born-global firm

    OpenAIRE

    Gary A Knight; S Tamer Cavusgil

    2004-01-01

    We investigate born-global firms as early adopters of internationalization – that is, companies that expand into foreign markets and exhibit international business prowess and superior performance, from or near their founding. Our explication highlights the critical role of innovative culture, as well as knowledge and capabilities, in this unique breed of international, entrepreneurial firm. Case studies are analyzed to better understand the early internationalization phenomenon and reveal ke...

  7. Memory Processes in Learning Disability Subtypes of Children Born Preterm

    OpenAIRE

    McCoy, Thomasin E; Conrad, Amy L.; Richman, Lynn C.; Nopoulos, Peg C.; Bell, Edward F.

    2012-01-01

    The purpose of this study was to evaluate immediate auditory and visual memory processes in learning disability subtypes of 40 children born preterm. Three subgroups of children were examined: (a) primary language disability group (n = 13), (b) perceptual-motor disability group (n = 14), and (c) no learning disability diagnosis group without identified language or perceptual-motor learning disability (n = 13). Between-group comparisons indicate no significant differences in immediate auditory...

  8. Prevalence of vector-borne pathogens in dogs from Haiti.

    Science.gov (United States)

    Starkey, Lindsay A; Newton, Kassie; Brunker, Jill; Crowdis, Kelly; Edourad, Emile Jean Pierre; Meneus, Pedro; Little, Susan E

    2016-07-15

    Canine vector-borne pathogens are common on some Caribbean islands, but survey data in Haiti are lacking. To determine the prevalence of selected vector-borne pathogens in dogs from Haiti, we tested blood samples collected from 210 owned dogs, 28 (13.3%) of which were infested with Rhipicephalus sanguineus ticks at the time of blood collection. No other tick species were identified on these dogs. A commercially available ELISA identified antibodies to Ehrlichia spp. in 69 (32.9%), antibodies to Anaplasma spp. in 37 (17.6%), and antigen of Dirofilaria immitis in 55 (26.2%); antibodies to Borrelia burgdorferi were not detected in any sample. Molecular assays of whole blood from 207 of the dogs confirmed infection with Ehrlichia canis (15; 7.2%), Anaplasma platys (13; 6.3%), D. immitis (46; 22.2%), Wolbachia spp. (45; 21.7%), Babesia vogeli (16; 7.7%), and Hepatozoon canis (40; 19.3%), but Anaplasma phagocytophilum, Babesia canis, Babesia rossi, Babesia gibsoni, Ehrlichia chaffeensis, Ehrlichia ewingii, or Hepatozoon americanum were not detected. Co-infection with two or more vector-borne pathogens was detected by serology in 42 (20.0%) dogs and by molecular assays in 22 (10.6%) dogs; one dog was co-infected with B. vogeli and E. canis as detected by PCR with D. immitis detected by serology (antigen). Overall, evidence of past or current infection with at least one vector-borne pathogen was identified in 142/210 (67.6%) dogs in this study, underscoring the common nature of these pathogens, some of which are zoonotic, in Haiti. PMID:27270383

  9. Global Change and Human Vulnerability to Vector-Borne Diseases

    OpenAIRE

    Sutherst, Robert W.

    2004-01-01

    Global change includes climate change and climate variability, land use, water storage and irrigation, human population growth and urbanization, trade and travel, and chemical pollution. Impacts on vector-borne diseases, including malaria, dengue fever, infections by other arboviruses, schistosomiasis, trypanosomiasis, onchocerciasis, and leishmaniasis are reviewed. While climate change is global in nature and poses unknown future risks to humans and natural ecosystems, other local changes ar...

  10. Weyl invariant Dirac-Born-Infeld-Einstein theory

    CERN Document Server

    Kan, Nahomi; Shiraishi, Kiyoshi

    2010-01-01

    We consider a Weyl invariant extension of Dirac-Born-Infeld type gravity. An appropriate choice of the metric hides the scalar degree of freedom which is required by the local scale invariance of the action at the first sight, and then a vector field acquires mass. Moreover, nonminimal couplings of the vector field and curvatures are induced, which may be suitable to the vector inflation scenario.

  11. Motion Compensation for Aircraft-Borne Interferometric SAR

    OpenAIRE

    Bullock, R J

    2003-01-01

    This research has studied data driven techniques for roll compensation for aircraft-borne InSAR, for platforms where an accurate Inertial Navigation Unit (INU) is inappropriate due to limitations on weight or cost, such as a low-cost civilian mapping system or a miniature UAV. It is shown that for unknown topography, roll errors cannot simply be filtered from the interferogram due to a fundamental ambiguity between aircraft roll effects and certain types of undulating terrain. ...

  12. Neural correlates of executive attention in adults born very preterm

    Science.gov (United States)

    Daamen, Marcel; Bäuml, Josef G.; Scheef, Lukas; Meng, Chun; Jurcoane, Alina; Jaekel, Julia; Sorg, Christian; Busch, Barbara; Baumann, Nicole; Bartmann, Peter; Wolke, Dieter; Wohlschläger, Afra; Boecker, Henning

    2015-01-01

    Very preterm birth is associated with an increased prevalence of attention problems and may especially impair executive attention, i.e., top-down control of attentional selection in situations where distracting information interferes with the processing of task-relevant stimuli. While there are initial findings linking structural brain alterations in preterm-born individuals with attention problems, the functional basis of these problems are not well understood. The present study used an fMRI adaptation of the Attentional Network Test to examine the neural correlates of executive attention in a large sample of N = 86 adults born very preterm and/or with very low birth weight (VP/VLBW), and N = 100 term-born controls. Executive attention was measured by comparing task behavior and brain activations associated with the processing of incongruent vs. congruent arrow flanker stimuli. Consistent with subtle impairments of executive attention, the VP/VLBW group showed lower accuracy and a tendency for increased response times during the processing of incongruent stimuli. Both groups showed similar activation patters, especially within expected fronto-cingulo-parietal areas, but no significant between-group differences. Our results argue for a maintained attention-relevant network organization in high-functioning preterm born adults in spite of subtle deficits in executive attention. Gestational age and neonatal treatment variables showed associations with task behavior, and brain activation in the dorsal ACC and lateral occipital areas, suggesting that the degree of prematurity (and related neonatal complications) has subtle modulatory influences on executive attention processing. PMID:26640769

  13. Millisecond newly born pulsars as efficient accelerators of electrons

    OpenAIRE

    Zaza Osmanov; Swadesh Mahajan; George Machabeli; Nino Chkheidze

    2015-01-01

    The newly born millisecond pulsars are investigated as possible energy sources for creating ultra-high energy electrons. The transfer of energy from the star rotation to high energy electrons takes place through the Landau damping of centrifugally driven (via a two stream instability) electrostatic Langmuir waves. Generated in the bulk magnetosphere plasma, such waves grow to high amplitudes, and then damp, very effectively, on relativistic electrons driving them to even higher energies. We s...

  14. Approaches towards tick and tick-borne diseases control

    OpenAIRE

    Ana Domingos; Sandra Antunes; Lara Borges; Virgilio Estolio do Rosario

    2013-01-01

    Ticks are obligate haematophagous ectoparasites of wild and domestic animals as well as humans, considered to be second worldwide to mosquitoes as vectors of human diseases. Tick-borne diseases are responsible worldwide for great economic losses in terms of mortality and morbidity of livestock animals. This review concerns to the different tick and tick-parasites control methods having a major focus on vaccines. Control of tick infestations has been mainly based on the use of acaricides, a co...

  15. Adiposity in children born small for gestational age.

    Science.gov (United States)

    Tappy, L

    2006-12-01

    Epidemiological studies indicate that children born small for gestational age (SGA) have an increased risk of metabolic and cardiovascular disorders as adults. This suggests that foetal undernutrition leads to permanent metabolic alterations, which predispose to metabolic abnormalities upon exposure to environmental factors such as low physical activity and/or high-energy intake in later life (thrifty phenotype hypothesis). However, this relationship is not restricted to foetal undernutrition or intrauterine growth retardation, but is also found for children born premature, or for high birth weight children. Furthermore, early post-natal nutrition, and more specifically catch-up growth, appear to modulate cardiovascular risk as well. Intrauterine growth retardation can be induced in animal models by energy/protein restriction, or ligation of uterine arteries. In such models, altered glucose homeostasis, including low beta-cell mass, low insulin secretion and insulin resistance is observed after a few weeks of age. In humans, several studies have confirmed that children born SGA have insulin resistance as adolescents and young adults. Alterations of glucose homeostasis and increased lipid oxidation can indeed be observed already in non-diabetic children born SGA at early pubertal stages. These children also have alterations of stature and changes in body composition (increased fat mass), which may contribute to the pathogenesis of insulin resistance. Permanent metabolic changes induced by foetal/early neonatal nutrition (metabolic inprinting) may involve modulation of gene expression through DNA methylation, or alterations of organ structure. It is also possible that events occurring during foetal/neonatal development lead to long-lasting alterations of the hypothalamo-pituitary-adrenal axis or the hypothalamo-pituitary-insulin-like growth factor-1 axis. PMID:17133233

  16. Feed-borne transmission and case clustering of BSE.

    OpenAIRE

    Hagenaars, T J; Ferguson, N. M.; Donnelly, C A; Ghani, A.C.; Anderson, R M

    2000-01-01

    An unresolved issue in the epidemiology of bovine spongiform encephalopathy (BSE) in the UK is what precisely determines the degree to which cases of disease in cattle are clustered within herds throughout the course of the epidemic. This paper presents an analysis of feed-borne transmission at the herd level and tests various models of case-clustering mechanisms, associated with heterogeneity in exposure to infectious feed, against observed epidemic pattern. We use an age-structured metapopu...

  17. Elimination of vector-borne transmission of Chagas disease

    OpenAIRE

    AC Silveira; MC Vinhaes

    1999-01-01

    The control of the vector-borne transmission of Chagas disease in Brazil was organized as a national program in 1975, when two large entomological and sero-epidemiological surveys were conducted in the country in order to identify areas at highest risk of transmission and to guide inerventions regarding the chemical treatment of domestic vectors of the disease. The authors present the baseline data gathered through these studies and compare them with more recent data. The evaluation performed...

  18. The epidemic threshold of vector-borne diseases with seasonality

    OpenAIRE

    Bacaër, Nicolas; Guernaoui, S.

    2006-01-01

    Cutaneous leishmaniasis is a vector-borne disease transmitted to humans by sandflies. In this paper, we develop a mathematical model which takes into account the seasonality of the vector population and the distribution of the latent period from infection to symptoms in humans. Parameters are fitted to real data from the province of Chichaoua, Morocco. We also introduce a generalization of the definition of the basic reproduction number R-0 which is adapted to periodic environments. This R-0 ...

  19. Resurgent vector-borne diseases as a global health problem.

    OpenAIRE

    Gubler, D. J.

    1998-01-01

    Vector-borne infectious diseases are emerging or resurging as a result of changes in public health policy, insecticide and drug resistance, shift in emphasis from prevention to emergency response, demographic and societal changes, and genetic changes in pathogens. Effective prevention strategies can reverse this trend. Research on vaccines, environmentally safe insecticides, alternative approaches to vector control, and training programs for health-care workers are needed.

  20. Pure spinor superfields and Born-Infeld theory

    CERN Document Server

    Cederwall, Martin

    2011-01-01

    We present a method for introducing and analysing higher-derivative deformations of maximally supersymmetric field theories. Such terms are built in the pure spinor superfield framework, using a set of operators representing physical fields. The action for abelian Born-Infeld theory becomes polynomial in this language, and contains only a four-point interaction in addition to the free action. Simplifications also occur in the non-abelian case.

  1. Nucleoside Inhibitors of Tick-Borne Encephalitis Virus

    Czech Academy of Sciences Publication Activity Database

    Eyer, L.; Valdés, James J.; Gil, V.A.; Nencka, Radim; Hřebabecký, Hubert; Šála, Michal; Salát, J.; Černý, Jiří; Palus, Martin; De Clercq, E.; Růžek, Daniel

    2015-01-01

    Roč. 59, č. 9 (2015), s. 5483-5493. ISSN 0066-4804 R&D Projects: GA ČR GAP502/11/2116; GA MŠk(CZ) EE2.3.30.0032 Institutional support: RVO:60077344 ; RVO:61388963 Keywords : tick-borne encephalitis virus * infection * molecular analyses Subject RIV: EE - Microbiology, Virology; CC - Organic Chemistry (UOCHB-X) Impact factor: 4.476, year: 2014

  2. The virial theorem in Eddington-Born-Infeld gravity

    OpenAIRE

    Santos, Noelia S.; Santos, Janilo

    2015-01-01

    We consider the possibility that the Eddington-Born-Infeld (EBI) modified gravity provides an alternative explanation for the mass discrepancy in clusters of galaxies. For this purpose we derive the modified Einstein field equations, finding an additional "geometrical mass" term which provides an effective contribution to the gravitational binding energy. Using some approximations and assumptions for weak gravitational fields, and taking into account the collisionless relativistic Boltzmann e...

  3. Tick-borne encephalitis virus infection of cultured mouse macrophages

    Czech Academy of Sciences Publication Activity Database

    Ahantarig, A.; Růžek, Daniel; Vancová, Marie; Janowitz, A.; Šťastná, Hana; Tesařová, Martina; Grubhoffer, Libor

    2009-01-01

    Roč. 52, č. 5 (2009), s. 283-290. ISSN 0300-5526 R&D Projects: GA ČR GA524/06/1479; GA MŠk(CZ) LC06009 Institutional research plan: CEZ:AV0Z60220518 Keywords : tick-borne encephalitis * macrophages * electron microscopy Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine Impact factor: 1.106, year: 2009

  4. Air-borne contact dermatitis caused exclusively by xanthium strumarium

    OpenAIRE

    Pasricha J; Verma Kaushal; D′Souza Pascal

    1995-01-01

    Most cases having air-borne contact dermatitis (ABCD) in India are considered to be caused by Parthenium hysterophorus. In some cases however, other plants have also been noticed to give positive patch test reactions. We are reporting two cases presenting as ABCD who showed positive patch tests with Xanthium strumarium while the patch tests with Parthenium hysterophorus were negative. It is therefore necessary to realise that every case of ABCD is not caused by Parthenium, and patch testing w...

  5. Interpretation of second Born amplitudes in electron capture

    International Nuclear Information System (INIS)

    Exact sound Born amplitudes for 1s-1s electron capture are presented and interpreted in terms of contributions from intermediate states off the energy shell and on the energy shell. The classical model of Thomas corresponds to two-step scattering via one particular on-shell intermediate state. In the high-velocity limit for 1s-1s capture, this on-shell intermediate state of the Thomas model accounts for one-half of the total cross section, i.e., the second Born cross section. The other half comes from off-energy-shell intermediate states near the on-shell Thomas state. Above 5 MeV both the off-shell and on-shell amplitudes have a simple structure near the Thomas peak. Below 1 MeV, contributions from a broader range of intermediate states are evident in the amplitudes. Although the contribution from the Thomas state is not large below 1 MeV, other second Born effects are significant

  6. Cognitive ability in adolescents born small for gestational age

    DEFF Research Database (Denmark)

    Jensen, Rikke Beck; Juul, Anders; Larsen, Torben;

    2015-01-01

    BACKGROUND: Small size at birth may be associated with impaired cognitive ability later in life. The aim of this study was to examine the effect of being born small for gestational age (SGA), with or without intrauterine growth restriction (IUGR) on cognitive ability in late adolescence. STUDY...... cognitive ability in late adolescence. Full-scale IQ was positively related to head circumference (HC) in adolescence (B: 1.30, 95% CI: 0.32-2.28, p=0.01). HC at birth and three months was positively associated with full-scale IQ. Catch-up growth in the group of SGA children was associated with a...... significantly increased height, larger HC, increased levels of insulin-like growth factor-I (IGF-I) and increased full-scale IQ compared to those born SGA without catch-up growth. CONCLUSION: SGA and IUGR may not be harmful for adult cognitive ability, at least not in individuals born at near-term. However...

  7. Arthropod-borne infections in travelled dogs in Europe

    Directory of Open Access Journals (Sweden)

    Hamel Dietmar

    2013-01-01

    Full Text Available Pet animal movement is ever increasing within the European Union and in that context canine vectorborne infections gained a considerable importance. Information on these infections in travelled dogs is nevertheless limited. A first prospective study on vector-borne infections was conducted in 106 dogs travelling from Germany to countries in South and South-East Europe. The dogs were screened prior to and consecutively up to three times after travel by haematological (Giemsa-stained buffy coat smears, Knott’s-Test, molecular biological (PCR as well as serological (IFAT, DiroChek®-ELISA methods for arthropod-borne infections. Seven animals were seropositive for antibodies against Babesia canis sspp., Leishmania spp. and/or Ehrlichia canis prior to travel to Italy, Spain, France, Croatia, Greece, or Hungary. In the consecutive screening after return there was no increase in the number of seropositive dogs. None was positive in direct methods. The mean duration of the stay was 17 days and 51% of the dogs were prophylactically treated with ectoparasiticidal formulations. Preliminary data from this study on canine vector-borne infections indicate a low risk for infection during a limited single stay in endemic countries.

  8. Food-borne bacteremic illnesses in febrile neutropenic children.

    Science.gov (United States)

    Lee, Anselm Chi-Wai; Siao-Ping Ong, Nellie Dawn

    2011-08-31

    Bacteremia following febrile neutropenia is a serious complication in children with malignancies. Preventive measures are currently targeted at antimicrobial prophylaxis, amelioration of drug-induced neutropenia, and nosocomial spread of pathogens, with little attention to community-acquired infections. A retrospective study was conducted at a pediatric oncology center during a 3-year period to identify probable cases of food-borne infections with bacteremia. Twenty-one bacteremic illnesses affecting 15 children receiving chemotherapy or hematopoietic stem cell transplantation were reviewed. Three (14%) episodes were highly suspected of a food-borne origin: a 17-year-old boy with osteosarcoma contracted Sphingomonas paucimobilis septicemia after consuming nasi lemak bought from a street hawker; a 2-year-old boy with acute lymphoblastic leukemia developed Chryseobacterium meningosepticum septicemia after a sushi dinner; a 2-year-old girl was diagnosed with acute lymphoblastic leukemia and Lactobacillus bacteremia suspected to be of probiotic origin. All of them were neutropenic at the time of the infections and the bacteremias were cleared with antibiotic treatment. Food-borne sepsis may be an important, but readily preventable, cause of bloodstream infections in pediatric oncology patients, especially in tropical countries with an abundance of culinary outlets. PMID:22184532

  9. Food-borne bacteremic illnesses in febrile neutropenic children

    Directory of Open Access Journals (Sweden)

    Anselm Chi-wai Lee

    2011-08-01

    Full Text Available Bacteremia following febrile neutropenia is a serious complication in children with malignancies. Preventive measures are currently targeted at antimicrobial prophylaxis, amelioration of drug-induced neutropenia, and nosocomial spread of pathogens, with little attention to community-acquired infections. A retrospective study was conducted at a pediatric oncology center during a 3-year period to identify probable cases of food-borne infections with bacteremia. Twenty-one bacteremic illnesses affecting 15 children receiving chemotherapy or hematopoietic stem cell transplantation were reviewed. Three (14% episodes were highly suspected of a food-borne origin: a 17-year-old boy with osteosarcoma contracted Sphingomonas paucimobilis septicemia after consuming nasi lemak bought from a street hawker; a 2-year-old boy with acute lymphoblastic leukemia developed Chryseobacterium meningosepticum septicemia after a sushi dinner; a 2-year-old girl was diagnosed with acute lymphoblastic leukemia and Lactobacillus bacteremia suspected to be of probiotic origin. All of them were neutropenic at the time of the infections and the bacteremias were cleared with antibiotic treatment. Food-borne sepsis may be an important, but readily preventable, cause of bloodstream infections in pediatric oncology patients, especially in tropical countries with an abundance of culinary outlets.

  10. Observational constraints on electromagnetic Born-Infeld cosmology

    International Nuclear Information System (INIS)

    The cosmological model consisting of an electromagnetic Born-Infeld (BI) field coupled to a Robertson-Walker geometry is tested with the standard probes of SNIa, GRBs and direct Hubble parameter. The analysis shows that the inclusion of the nonlinear electromagnetic component does not contribute in a significative way to the observed expansion. The BI electromagnetic matter is considered with an abundance of ΩBI, that our best fit leads to ΩBI = 0.037 when tested with SNIa and the Hubble parameter data (0.1 BI = 0.304, which may indicate that this electrodynamics was important at epochs close to the appearance of large structure (z ≈ 7), although this late result has not as much reliability as that corresponding to the first two probes, since we know that the dispersion in GRBs data is still considerable. In view of these results we can rule out the electromagnetic Born-Infeld matter as the origin of the present accelerated expansion, this conclusion concerns exclusively the Born-Infeld theory

  11. Adult psychological functioning of individuals born with craniofacial anomalies.

    Science.gov (United States)

    Sarwer, D B; Bartlett, S P; Whitaker, L A; Paige, K T; Pertschuk, M J; Wadden, T A

    1999-02-01

    This study represents an initial investigation into the adult psychological functioning of individuals born with craniofacial disfigurement. A total of 24 men and women born with a craniofacial anomaly completed paper and pencil measures of body image dissatisfaction, self-esteem, quality of life, and experiences of discrimination. An age- and gender-matched control group of 24 non-facially disfigured adults also completed the measures. As expected, craniofacially disfigured adults reported greater dissatisfaction with their facial appearance than did the control group. Craniofacially disfigured adults also reported significantly lower levels of self-esteem and quality of life. Dissatisfaction with facial appearance, self-esteem, and quality of life were related to self-ratings of physical attractiveness. More than one-third of craniofacially disfigured adults (38 percent) reported experiences of discrimination in employment or social settings. Among disfigured adults, psychological functioning was not related to number of surgeries, although the degree of residual facial deformity was related to increased dissatisfaction with facial appearance and greater experiences of discrimination. Results suggest that adults who were born with craniofacial disfigurement, as compared with non-facially disfigured adults, experience greater dissatisfaction with facial appearance and lower self-esteem and quality of life; however, these experiences do not seem to be universal. PMID:9950526

  12. Impact of post-Born lensing on the CMB

    CERN Document Server

    Pratten, Geraint

    2016-01-01

    Lensing of the CMB is affected by post-Born lensing, producing corrections to the convergence power spectrum and introducing field rotation. We show numerically that the lensing convergence power spectrum is affected at the $\\lesssim 0.2\\%$ level on accessible scales, and that this correction and the field rotation are negligible for observations with arcminute beam and noise levels $\\gtrsim 1 \\mu {\\text{K}}\\,{\\text{arcmin}} $. The field rotation generates $\\sim 2.5\\%$ of the total lensing B-mode polarization amplitude ($0.2\\%$ in power on small scales), but has a blue spectrum on large scales, making it highly subdominant to the convergence B modes on scales where they are a source of confusion for the signal from primordial gravitational waves. Since the post-Born signal is non-linear, it also generates a bispectrum with the convergence. We show that the post-Born contributions to the bispectrum substantially change the shape predicted from large-scale structure non-linearities alone, and hence must be incl...

  13. Review of vector-borne diseases in Hong Kong.

    Science.gov (United States)

    Ma, Siu-keung Edmond; Wong, Wang Christine; Leung, Chi-wah Ryan; Lai, Sik-to Thomas; Lo, Yee-chi Janice; Wong, Kai-hay Howard; Chan, Man-chung; Que, Tak-lun; Chow, Ka-wai Mary; Yuen, Ming-chi; Lau, Tin-wai Winnie; Simon, John

    2011-05-01

    The epidemiology of vector-borne diseases in Hong Kong has changed over the past decade but still poses a significant public health risk. We provided a comprehensive review of the epidemiological information and analysed the trends of major vector-borne diseases, including the vector situation in Hong Kong. The incidence of malaria has dropped dramatically in the past few decades and is now mainly an imported disease acquired from malaria endemic countries. Locally acquired dengue fever occurred in 2002 and 2003, and thereafter all cases were imported, mainly from Southeast Asia areas. Only a few local cases of Japanese encephalitis were reported in the past decade. In contrast, there is a notable increase in scrub typhus and spotted fever cases. The emergence of chikungunya fever in Asia and Indian Ocean countries also resulted in importation of human cases. Given the heavy traffic between this international city and other parts of the world, as well as the presence of vectors in this densely populated area, vigilance should be maintained against these infections. Comprehensive public health measures encompassing disease surveillance, vector surveillance and control measures with support from all sectors of the community are required to combat the old and newly emerging vector-borne diseases in Hong Kong. PMID:21679886

  14. Critical behavior of Born-Infeld dilaton black holes

    Science.gov (United States)

    Dehghani, M. H.; Sheykhi, A.; Dayyani, Z.

    2016-01-01

    We explore the critical behavior of (n +1 )-dimensional topological Born-Infeld-dilaton black holes in an extended phase space. We treat the cosmological constant and the Born-Infeld (BI) parameter as the thermodynamic pressure and BI vacuum polarization which can vary. We obtain thermodynamic quantities of the system such as pressure, temperature, Gibbs free energy, and investigate the behavior of these quantities. We also study the analogy of the van der Waals liquid-gas system with the Born-Infeld-dilaton black holes in canonical ensemble in which we can treat the black hole charge as a fixed external parameter. Moreover, we show that the critical values of pressure, temperature and volume are physical provided the coupling constant of dilaton gravity is less than 1 and the horizon is sphere. Finally, we calculate the critical exponents and show that although thermodynamic quantities depend on the dilaton coupling constant, BI parameter and the dimension of the spacetime, they are universal and are independent of metric parameters.

  15. SIGNR1-Negative Red Pulp Macrophages Protect against Acute Streptococcal Sepsis after Leishmania donovani-Induced Loss of Marginal Zone Macrophages

    OpenAIRE

    Kirby, Alun C.; Beattie, Lynette; Maroof, Asher; van Rooijen, Nico; Kaye, Paul M.

    2009-01-01

    Marginal zone macrophages in the murine spleen play an important role in the capture of blood-borne pathogens and are viewed as an essential component of host defense against the development of pneumococcal sepsis. However, we and others have previously described the loss of marginal zone macrophages associated with the splenomegaly that follows a variety of viral and protozoal infections; this finding raises the question of whether these infected mice would become more susceptible to seconda...

  16. The Training Requirements of Foreign-Born Workers in Different Countries

    Science.gov (United States)

    Ryan, Chris; Sinning, Mathias

    2012-01-01

    The training requirements of foreign-born workers may be different from those of native-born workers in similar jobs. Over recent decades Australian immigration policy has focused predominantly on accepting high-skilled migrants. Although this focus has resulted in the successful integration of foreign-born workers into the Australian labour…

  17. Foreign-Born Instructors in the U.S.: Intercultural Competence, Teaching Strategies, and Job Satisfaction

    Science.gov (United States)

    Wasilik, Oksana

    2011-01-01

    This study examines intercultural competence, teaching strategies, and job satisfaction of foreign-born instructors in a small U.S. higher education institution. The research questions addressed by this study are: (1) How do foreign-born instructors score on intercultural competence? (2) How do foreign-born instructors' teaching strategies differ…

  18. Certain Cancers Seem Less Likely for Kids of Hispanic Moms Born Outside U.S.

    Science.gov (United States)

    ... Likely for Kids of Hispanic Moms Born Outside U.S. Analyzing immigrant population can help identify tumor causes, ... 2012. The analysis was limited to children of U.S.-born white, U.S.-born Hispanic, or non-U.S.- ...

  19. Educational Needs of School-Aged Children Born Very and Extremely Preterm: A Review

    Science.gov (United States)

    Hornby, Garry; Woodward, Lianne J.

    2009-01-01

    Recent decades have witnessed dramatically improved survival rates for infants born prematurely, especially those born very and extremely preterm. Follow-up studies concerned with long-term neurodevelopmental outcomes for children born preterm indicate that these children are at high risk for a range of cognitive, learning, neuromotor, and…

  20. Pan-European Chikungunya surveillance: designing risk stratified surveillance zones.

    Science.gov (United States)

    Tilston, Natasha; Skelly, Chris; Weinstein, Phil

    2009-01-01

    The first documented transmission of Chikungunya within Europe took place in Italy during the summer of 2007. Chikungunya, a viral infection affecting millions of people across Africa and Asia, can be debilitating and no prophylactic treatment exists. Although imported cases are reported frequently across Europe, 2007 was the first confirmed European outbreak and available evidence suggests that Aedes albopictus was the vector responsible and the index case was a visitor from India. This paper proposed pan-European surveillance zones for Chikungunya, based on the climatic conditions necessary for vector activity and viral transmission. Pan-European surveillance provides the best hope for an early-warning of outbreaks, because national boundaries do not play a role in defining the risk of this new vector borne disease threat. A review of climates, where Chikungunya has been active, was used to inform the delineation of three pan-European surveillance zones. These vary in size each month across the June-September period of greatest risk. The zones stretch across southern Europe from Portugal to Turkey. Although the focus of this study was to define the geography of potential surveillance zones based on the climatic limits on the vector and virus, a preliminary examination of inward bound airline passengers was also undertaken. This indicated that France and Italy are likely to be at greater risk due to the number of visitors they receive from Chikungunya active regions, principally viraemic visitors from India. Therefore this study represents a first attempt at creating risk stratified surveillance zones, which we believe could be usefully refined with the use of higher resolution climate data and more complete air travel data. PMID:19878588

  1. Pan-European Chikungunya surveillance: designing risk stratified surveillance zones

    Directory of Open Access Journals (Sweden)

    Skelly Chris

    2009-10-01

    Full Text Available Abstract The first documented transmission of Chikungunya within Europe took place in Italy during the summer of 2007. Chikungunya, a viral infection affecting millions of people across Africa and Asia, can be debilitating and no prophylactic treatment exists. Although imported cases are reported frequently across Europe, 2007 was the first confirmed European outbreak and available evidence suggests that Aedes albopictus was the vector responsible and the index case was a visitor from India. This paper proposed pan-European surveillance zones for Chikungunya, based on the climatic conditions necessary for vector activity and viral transmission. Pan-European surveillance provides the best hope for an early-warning of outbreaks, because national boundaries do not play a role in defining the risk of this new vector borne disease threat. A review of climates, where Chikungunya has been active, was used to inform the delineation of three pan-European surveillance zones. These vary in size each month across the June-September period of greatest risk. The zones stretch across southern Europe from Portugal to Turkey. Although the focus of this study was to define the geography of potential surveillance zones based on the climatic limits on the vector and virus, a preliminary examination of inward bound airline passengers was also undertaken. This indicated that France and Italy are likely to be at greater risk due to the number of visitors they receive from Chikungunya active regions, principally viraemic visitors from India. Therefore this study represents a first attempt at creating risk stratified surveillance zones, which we believe could be usefully refined with the use of higher resolution climate data and more complete air travel data.

  2. Culture and Household Decision Making: Balance of Power and Labor Supply Choices of US-born and Foreign-born Couples

    OpenAIRE

    Oreffice, Sonia

    2014-01-01

    This study investigates how spouses' cultural backgrounds mediate the role of intra-household bargaining in the labor supply decisions of foreign-born and US-born couples, in a collective-household framework. Using data from the 2000 US Census, I show that the hours worked by US-born couples, and by those foreign-born coming from countries with gender roles similar to the US, are significantly related to common bargaining power forces such as differences between spouses in age and non-labor i...

  3. The Internationalization Process within Born Global Companies : How Swedish Born Globals Utilize Resources in the Internationalization Process

    OpenAIRE

    Huhta, Fredrik; Huhta, Henrik

    2014-01-01

    The purpose with this thesis is to explain and explore how born global companies utilize important resources in the internationalization process. The globalized world that we live in today has increased the information sharing and new technologies have changed the way companies approach the international market. Evidence in previous literature has revealed that companies have a faster approach to the international market and tend to skip the incremental internationalization process that the t...

  4. Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the adult rat brain

    Science.gov (United States)

    Rivera, Patricia; Blanco, Eduardo; Bindila, Laura; Alen, Francisco; Vargas, Antonio; Rubio, Leticia; Pavón, Francisco J.; Serrano, Antonia; Lutz, Beat; Rodríguez de Fonseca, Fernando; Suárez, Juan

    2015-01-01

    Chronic alcohol exposure reduces endocannabinoid activity and disrupts adult neurogenesis in rodents, which results in structural and functional alterations. Cannabinoid receptor agonists promote adult neural progenitor cell (NPC) proliferation. We evaluated the protective effects of the selective CB1 receptor agonist ACEA, the selective CB2 receptor agonist JWH133 and the fatty-acid amide-hydrolase (FAAH) inhibitor URB597, which enhances endocannabinoid receptor activity, on NPC proliferation in rats with forced consumption of ethanol (10%) or sucrose liquid diets for 2 weeks. We performed immunohistochemical and stereological analyses of cells expressing the mitotic phosphorylation of histone-3 (phospho-H3+) and the replicating cell DNA marker 5-bromo-2'-deoxyuridine (BrdU+) in the main neurogenic zones of adult brain: subgranular zone of dentate gyrus (SGZ), subventricular zone of lateral ventricles (SVZ) and hypothalamus. Animals were allowed ad libitum ethanol intake (7.3 ± 1.1 g/kg/day) after a controlled isocaloric pair-feeding period of sucrose and alcoholic diets. Alcohol intake reduced the number of BrdU+ cells in SGZ, SVZ, and hypothalamus. The treatments (URB597, ACEA, JWH133) exerted a differential increase in alcohol consumption over time, but JWH133 specifically counteracted the deleterious effect of ethanol on NPC proliferation in the SVZ and SGZ, and ACEA reversed this effect in the SGZ only. JWH133 also induced an increased number of BrdU+ cells expressing neuron-specific β3-tubulin in the SVZ and SGZ. These results indicated that the specific activation of CB2 receptors rescued alcohol-induced impaired NPC proliferation, which is a potential clinical interest for the risk of neural damage in alcohol dependence. PMID:26483633

  5. Zone refining of plutonium metal

    International Nuclear Information System (INIS)

    The zone refining process was applied to Pu metal containing known amounts of impurities. Rod specimens of plutonium metal were melted into and contained in tantalum boats, each of which was passed horizontally through a three-turn, high-frequency coil in such a manner as to cause a narrow molten zone to pass through the Pu metal rod 10 times. The impurity elements Co, Cr, Fe, Ni, Np, U were found to move in the same direction as the molten zone as predicted by binary phase diagrams. The elements Al, Am, and Ga moved in the opposite direction of the molten zone as predicted by binary phase diagrams. As the impurity alloy was zone refined, δ-phase plutonium metal crystals were produced. The first few zone refining passes were more effective than each later pass because an oxide layer formed on the rod surface. There was no clear evidence of better impurity movement at the slower zone refining speed. Also, constant or variable coil power appeared to have no effect on impurity movement during a single run (10 passes). This experiment was the first step to developing a zone refining process for plutonium metal

  6. Management of coastal zone vegetation

    Digital Repository Service at National Institute of Oceanography (India)

    Untawale, A.G.

    stream_size 14 stream_content_type text/plain stream_name Trg_Course_Coast_Zone_Manage_1993_22.pdf.txt stream_source_info Trg_Course_Coast_Zone_Manage_1993_22.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset...

  7. Instrumentation for coastal zone management

    Digital Repository Service at National Institute of Oceanography (India)

    Joseph, A.

    stream_size 11 stream_content_type text/plain stream_name Trg_Course_Coast_Zone_Manage_1993_91.pdf.txt stream_source_info Trg_Course_Coast_Zone_Manage_1993_91.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset...

  8. Fresnel zone plate coded imaging

    International Nuclear Information System (INIS)

    The author introduced the principle of the Fresnel-zone-plate coded imaging, and design a Fresnel zone plate coded image camera with high spatial resolution. A experimental simulation with two-aperture visible light source is made. The result shows that this coded image camera can reveal the source distribution truly

  9. Excavation damaged zone

    Energy Technology Data Exchange (ETDEWEB)

    Popp, T.; Salzer, K.; Minkley, W. [Institut fur Gebirgsmechanik GmbH, Leipzig (Germany); Gibert, D.; Nicollin, F.; Kergosien, B. [Rennes-1 Univ., GdR FORPRO (CNRS/ANDRA GdR 788) and Geosciences Rennes (CNRS/UR1 UMR 6118) (France); Bossart, P. [Federal Office for Topography, Wabern (Switzerland); Nussbaum, C. [Institut Geotechnique SA, St-Ursanne (Switzerland); Robinet, J.C.; Nguyen, M.T. [EGC Euro-Geomat-Consulting, 45 - Orleans (France); Barnichon, J.D.; Plas, F. [ANDRA - Agence Nationale pour la Gestion des Dechets Radioactifs, 92 - Chatenay Malabry (France); Ghorbani, A.; Cosenza, P.; Florsch, N. [Pierre et Marie Curie Univ., UMR 7619 Sisyphe, 75 - Paris (France); Revil, A.; Jougnot, D. [Aix-Marseille-2, UMR 6635, CNRS-CEREGE, 13 (France); Schmutz, M. [EGID, M. de Montaigne Univ., 33 - Pessac (France); Contrucci, I.; Klein, E. [Institut National de l' Environnement Industriel et des Risques (INERIS), Ecole des Mines de Nancy, 54 - Nancy (France); Cabrera, J.; Ben-Slimane, K.; Rejeb, A.; Matray, J.M.; Savoye, S. [Institut de Radioprotection et de Surete Nucleaire (IRSN), 92 - Fontenay-aux-Roses (France); Maiolino, S. [Ecole Polytechnique, Lab. de Mecanique des Solides, UMR 7649, LMS, 91 - Palaiseau (France); CETE de Lyon/LRPC de Lyon/Meca Roches/ ERA, 69 - Bron (France); Yong, S.; Loew, S.; Fidelibus, C.; Lemy, F. [Engineering Geology, ETH Zurich, Zurich (Switzerland); Frank, E. [Swiss Federal Nuclear Safety Inspectorate (HSK), Villigen (Switzerland); Chun-Liang, Zhang; Tilmann, Rothfuchs [Gesellschaft fur Anlagen- und Reaktorsicherheit (GRS) mbH, Braunschweig (Germany)

    2007-07-01

    This session gathers 10 articles (posters) dealing with: the influence of bedding planes to EDZ evolution and the coupled HM properties of Opalinus Clay; the electrical tomography monitoring of the EDZ during the excavation of the gallery 04 in the Mont Terri rock laboratory; the seismic endoscopy and tomography of the EDZ of the gallery 04 in the Mont Terri rock laboratory; a elastoplastic damage model for saturated and unsaturated stiffness clays: description and application to the modelling of EDZ around drifts in Callovo-Oxfordian argillites; the non-invasive monitoring of water content and microcracks in argillites using spectral induced polarization; EDZ investigations by ultrasonic borehole logging in drifts of different ages excavated in argillaceous formations of the Tournemire experimental station (Aveyron, France); the excavation damaged zones in the argillaceous Tournemire site: characterisation and failure mechanisms; the hardening-based degradation factor: influence of mean stress and stiffness; the disturbance in the EDZ in the Opalinus clay at Mont Terri; and the experimental study on self-sealing capacity of clay rocks.

  10. Emergency planning zone reduction

    International Nuclear Information System (INIS)

    This paper describes the process used by a large industrial Department of Energy (DOE) site to communicate changing hazards to its stakeholders and install the confidence necessary to implement the resulting emergency planning changes. Over the last decade as the sites missions have shifted from full-scale production to a greater emphasis on environmental restoration and waste management, the off-site threat from its operations has substantially decreased. The challenge was to clearly communicate the reduced hazards, install confidence in the technical analysis that documented the hazard reduction, and obtain stakeholder buy-in on the path forward to change the emergency management program. The most significant change to the emergency management program was the proposed reduction of the sites Emergency Planning Zone (EPZ). As the EPZ is defined as an area for which planning is needed to protect the public in the event of an accident, the process became politically challenging. An overview of how the site initially approached this problem and then learned to more substantially involve the state and local emergency preparedness agencies and the local Citizens Advisory Board will be presented. (author)

  11. Childbearing characteristics of U.S.- and foreign-born Hispanic mothers.

    OpenAIRE

    Ventura, S J; Taffel, S M

    1985-01-01

    This study compares maternal and infant health and sociodemographic characteristics of U.S.-born and foreign- or Puerto Rican-born Hispanic mothers and their babies, using data from the national vital statistics system and the 1980 National Natality Survey. While nearly half of all Hispanic mothers and Mexican and Puerto Rican mothers were born in the United States, less than 10 percent of Cuban and other Hispanic mothers were U.S. born. Compared with foreign- or Puerto Rican-born Hispanic mo...

  12. Perinatal outcomes in 6,338 singletons born after intrauterine insemination in Denmark, 2007 to 2012

    DEFF Research Database (Denmark)

    Malchau, Sara Sofia; Loft, Anne; Henningsen, Anna-Karina Aaris;

    2014-01-01

    OBJECTIVE: To study perinatal outcomes in singletons born after intrauterine insemination (IUI) compared with children born after in vitro fertilization (IVF), intracytoplasmic sperm injection, and spontaneous conception (SC), and to assess predictors of poor outcome in singletons born after IUI......, exploring the effect of ovarian stimulation. DESIGN: National cohort study, 2007-2012. SETTING: Danish national registries. PATIENT(S): Four thousand two hundred twenty-eight singletons born after insemination with partner semen (IUI-H) and 1,881 singletons born after insemination with donor semen...

  13. Suboptimal care and maternal mortality among foreign-born women in Sweden

    DEFF Research Database (Denmark)

    Esscher, Annika; Binder-Finnema, Pauline; Bødker, Birgit;

    2014-01-01

    that occurred in Sweden from 1988-2010. METHODS: A subset of maternal death records (n = 75) among foreign-born women from low- and middle-income countries and Swedish-born women were audited using structured implicit review. One case of foreign-born maternal death was matched with two native born...... incongruent language and suboptimal interpreter system or usage. Inadequate care occurred more often among the foreign-born (p = 0.04), whereas delays in consultation/referral and miscommunication between health care providers where equally common between the two groups. CONCLUSIONS: Suboptimal care factors...

  14. Global from the Start: The Characteristics of Born-Global Firms in the Technology Sector

    Directory of Open Access Journals (Sweden)

    Stoyan Tanev

    2012-03-01

    Full Text Available This article provides insights from recent research on firms that are "born global". A born-global firm is a venture launched to exploit a global niche from the first day of its operations. The insights in this article are relevant to technology entrepreneurs and top management teams of new technology firms. After discussing various definitions for the term "born global" and identifying the main characteristics of born-global firms, this article lists a few salient characteristics of firms that are born global in the technology sector. The article concludes by identifying opportunities for future research.

  15. Global from the Start: The Characteristics of Born-Global Firms in the Technology Sector

    DEFF Research Database (Denmark)

    Tanev, Stoyan

    2016-01-01

    This article provides insights from recent research on firms that are “born global”. A born-global firm is a venture launched to exploit a global niche from the first day of its operations. The insights in this article are relevant to technology entrepreneurs and top management teams of new...... technology firms. After discussing various definitions for the term “born global” and identifying the main characteristics of born-global firms, this article lists a few salient characteristics of firms that are born global in the technology sector. The article concludes by identifying opportunities for...

  16. Cancer in children and young adults born after assisted reproductive technology

    DEFF Research Database (Denmark)

    Sundh, Karin Jerhamre; Henningsen, Anna-Karina A; Källen, Karin;

    2014-01-01

    children born after spontaneous conception (1.8/1000 children, 18.8/100 000 person-years). Leukaemia was the most common type of cancer (n = 278, 0.62/1000 children) but no significantly increased incidence was found among children born after ART. An increased risk was observed for 2 of 12 cancer groups......STUDY QUESTION: Do children and young adults born after assisted reproductive technology (ART) have an increased risk of cancer? SUMMARY ANSWER: Children born after ART showed no overall increase in the rate of cancer when compared with children born as a result of spontaneous conception. WHAT...... IS KNOWN ALREADY: Children born after ART have more adverse perinatal outcomes, i.e. preterm births, low birthweights and birth defects. Previous studies have shown divergent results regarding the risk of cancer among children born after ART. STUDY DESIGN, SIZE, DURATION: A retrospective Nordic population...

  17. Bionomics of temperate and tropical Culicoides midges: knowledge gaps and consequences for transmission of Culicoides-borne viruses.

    Science.gov (United States)

    Purse, B V; Carpenter, S; Venter, G J; Bellis, G; Mullens, B A

    2015-01-01

    Culicoides midges are abundant hematophagous flies that vector arboviruses of veterinary and medical importance. Dramatic changes in the epidemiology of Culicoides-borne arboviruses have occurred since 1998, including the emergence of exotic viruses in northern temperate regions, increases in global disease incidence, and enhanced virus diversity in tropical zones. Drivers may include changes in climate, land use, trade, and animal husbandry. New Culicoides species and new wild reservoir hosts have been implicated in transmission, highlighting the dynamic nature of pathogen-vector-host interactions. Focusing on potential vector species worldwide and key elements of vectorial capacity, we review the sensitivity of Culicoides life cycles to abiotic and biotic factors. We consider implications for designing control measures and understanding impacts of environmental change in different ecological contexts. Critical geographical, biological, and taxonomic knowledge gaps are prioritized. Recent developments in genomics and mathematical modeling may enhance ecological understanding of these complex arbovirus systems. PMID:25386725

  18. 49 CFR 71.8 - Mountain zone.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Mountain zone. 71.8 Section 71.8 Transportation Office of the Secretary of Transportation STANDARD TIME ZONE BOUNDARIES § 71.8 Mountain zone. The fourth zone, the mountain standard time zone, includes that part of the United States that is west of...

  19. Mechanical properties of fracture zones

    International Nuclear Information System (INIS)

    Available data on mechanical characteristics of fracture zones are compiled and discussed. The aim is to improve the basis for adequate representation of fracture zones in geomechanical models. The sources of data researched are primarily borehole investigations and case studies in rock engineering, involving observations of fracture zones subjected to artificial load change. Boreholes only yield local information about the components of fracture zones, i.e. intact rock, fractures and various low-strength materials. Difficulties are therefore encountered in evaluating morphological and mechanical properties of fracture zones from borehole data. Although often thought of as macroscopically planar features, available field data consistently show that fracture zones are characterized by geometrical irregularities such as thickness variations, surface undulation and jogs. These irregularities prevail on all scales. As a result, fracture zones are on all scales characterized by large, in-plane variation of strength- and deformational properties. This has important mechanical consequences in terms of non-uniform stress transfer and complex mechanisms of shear deformation. Field evidence for these findings, in particular results from the underground research laboratory in Canada and from studies of induced fault slip in deep mines, is summarized and discussed. 79 refs

  20. Special Economic Zones In India

    Directory of Open Access Journals (Sweden)

    Dilip Khanderao Patil

    2013-07-01

    Full Text Available A Special Economic Zone (SEZ is a geographical region that has economic laws that are more liberal than a country's typical economic laws. The category 'SEZ' covers a broad range of more specific zone types, including Free Trade Zones (FTZ, Export processing zones (EPZ, Free Zones (FZ, Industrial Estates (IE, Free ports, Urban Enterprise Zones and others. Usually the goal of a structure is to increase foreign direct investment by foreign investors; typically an international business or a Multi National Corporation (MNC. The total physical exports from SEZs in India as on 31st December, 2012 i.e. in the first three quarters of the current financial year, has been to the tune of Rs. 3,53,195 crore approximately registering a growth of 35.34% over the exports of corresponding period of the previous financial year. The total investment in SEZs till 31st December, 2012 is Rs.2,38,990 crore approximately, including Rs.2,18,919 crore in the newly notified zones.

  1. INCIDENCE OF NEONATAL HYPERBILIRUBINEMEA IN TERM NEW BORNS AT KBNTGH

    Directory of Open Access Journals (Sweden)

    Mujumdar

    2015-11-01

    Full Text Available AIM AND SCOPE: We conducted this study to estimate the incidence of hyperbilirubinemia in term new born with birth weight >2.5 kgs born at neonatal care unit of KBNTGH, and to determine the underlying causes, which would be of value in identifying and implementing strategies to prevent morbidity from this condition. BACKGROUND: Management of hyperbilirubinemia remains a challenge for neonatal medicine because of the risk for serious neurological complications related to the toxicity of bilirubin. MATERIALS AND METHODS: From January 2014 to January 2015, we screened 525 newborns born at KBNTGH (Khaja Bandanawaz Teaching & General Hospital attached to Khaja Bandanawaz Institute of Medical Scienceswith complaints of yellowish discoloration of skin were screened for jaundice. Infants aged 3–5 days and with unconjugated hyperbilirubinemia were included for assessment if they had a peak serum total bilirubin level exceeding 10 mg/dl. Sex, birth weight, gestational age, breast feeding, type of birth, presence of facial bruising (Including cephalohematoma and ABO group were noted. Patients with Toxoplasma or Cytomegalovirus infection, hepatic insufficiency, or suspected drug-induced hyperbilirubinemia were excluded from more detailed analysis. RESULTS: Our year-long nursery sample examined otherwise healthy-appearing term infants with birth weigth>2.5kgs for the prevalence of hyperbilirubinemia (Defined as bilirubin levels exceeding 6 mg/dL [11mol/L]. We found hyperbilirubinemia in 19% (100/525. Among the patients with hyperbilirubinemia, 1.2% had peak levels of bilirubin 20 mg/dL, levels which are generally considered to be potentially neurotoxic. CONCLUSIONS: In our clinic experience, hyperbilirubinemia was generally a serious medical issue and one whose etiology can usually be well defined.

  2. An Epidemiological Investigation of Male-Female Differences in Drinking and Drinking-Related Problems between US-Born and Foreign-Born Latino and Asian Americans

    Directory of Open Access Journals (Sweden)

    Hui G. Cheng

    2013-01-01

    Full Text Available Background. It has been widely documented that males were more likely to drinking alcohol and have alcohol use disorders (AUD. The degrees of the male-female differences in drinking and AUD have varied across countries. The reasons behind these variations have not been fully understood. The current study compared the estimated male-female differences across US-born and foreign-born Latino and Asian Americans with respect to alcohol drinking behavior and AUD. Method. Data come from the National Latino and Asian American Study (NLAAS, a national household survey of adults with Latinos and Asian decent in the United States. Male-female differences were estimated for drinking behavior and AUD among drinkers for US-born and foreign-born individuals, respectively. Zero-inflated Poisson regressions were utilized to estimate male-female differences in the number of AUD clinical features once it occurs. Results. Larger male-female differences were found for foreign-born individuals as compared to US-born individuals, especially the occurrence of AUD among drinkers. Once AUD clinical feature occurs, there was no male-female difference for foreign-born individuals, while there was a males excess in the number of clinical features for US-born individuals. Conclusion. Results from this study supports the importance of sociocultural influence in drinking and AUD. Implications for prevention and intervention programs were discussed.

  3. Dietary Sodium Intakes and Food Sources of Sodium in Canadian-Born and Asian-Born Individuals of Chinese Ethnicity at a Canadian University Campus

    Science.gov (United States)

    Yu, Yan Han; Farmer, Anna; Mager, Diana; Willows, Noreen

    2014-01-01

    Objective: To document the sodium intake and food sources of sodium of Canadian-born Chinese (CBC) and Asian-born Chinese (ABC) individuals at a Canadian university campus. Participants: Healthy adults aged 18-58 years originating from Canada, China, Hong Kong, or Taiwan were recruited from the University of Alberta (n = 40 CBC, n = 41 ABC)…

  4. Perceptions of Clinical Education Preparedness at a Large Urban US University: Is There a Difference between US-Born and Non-US Born Students?

    Science.gov (United States)

    Cohen, Timmerie; Justice, M. Ferell; Dempsey, Melanie C.

    2014-01-01

    This research compared three clinical preparedness domains, communication ability, social comfort, and clinical confidence, between US-born and non-US born radiation sciences students. The aim of the study was to determine if there were perceived differences in clinical preparedness between them. Student's place of birth was found to be an…

  5. Problems of Chernobyl exclusion zone

    International Nuclear Information System (INIS)

    The collection comprises the results of researches and design activity in the ChNPP exclusion zone with the aim to develop technology, equipment and instruments for RAW management and accident clean-up, studying of the composition and structure of the activity solid bearers in the soil of the exclusion zone and transformation of the radionuclides in the nearest zone of ChNPP. Much attention is paid to medical and biological problems of the accident influence on the flora, fauna and people's health labour conditions and incidence of the people involved

  6. Problems of Chornobyl Exclusion Zone

    International Nuclear Information System (INIS)

    The collection comprises the results of researches and design activity in the ChNPP exclusion zone with the aim to develop technology, equipment and instruments for RAW management and accident clean-up, studying of the composition and structure of the activity solid bearers in the soil of the exclusion zone and transformation of the radionuclides in the nearest zone of ChNPP. Much attention is paid to medical and biological problems of the accident influence on the flora, fauna and people's health, labour conditions and incidence of the people involved.

  7. Preservation of ebooks: from digitized to born-digital

    OpenAIRE

    Derrot, Sophie; Moreux, Jean-Philippe; Oury, Clément; Reecht, Stéphane

    2014-01-01

    The scope of digital curation at the BnF covers documents digitized from BnF collections as well as born-digital material bought by the BnF or collected under its legal deposit mandate. It is therefore critical for the library to investigate if common approaches may be adopted for similar document types, whatever their origin may be. This paper proposes to focus on the case of electronic books (or ebooks), by comparing the way BnF teams intend to ensure the long term preservation of those dir...

  8. Domain wall universe in the Einstein-Born-Infeld theory

    OpenAIRE

    Lee, Bum-Hoon(Center for Quantum Spacetime, Sogang University, Seoul, 121-742, Republic of Korea); Lee, Wonwoo; Minamitsuji, Masato

    2009-01-01

    In this Letter, we discuss the dynamics of a domain wall universe embedded into the charged black hole spacetime of the Einstein-Born-Infeld (EBI) theory. There are four kinds of possible spacetime structures, i.e., those with no horizon, the extremal one, those with two horizons (as the Reissner-Nordstr$\\rm{\\ddot o}$m black hole), and those with a single horizon (as the Schwarzshild black hole). We derive the effective cosmological equations on the wall. In contrast to the previous works, we...

  9. Generalized extended Lagrangian Born-Oppenheimer molecular dynamics

    International Nuclear Information System (INIS)

    Extended Lagrangian Born-Oppenheimer molecular dynamics based on Kohn-Sham density functional theory is generalized in the limit of vanishing self-consistent field optimization prior to the force evaluations. The equations of motion are derived directly from the extended Lagrangian under the condition of an adiabatic separation between the nuclear and the electronic degrees of freedom. We show how this separation is automatically fulfilled and system independent. The generalized equations of motion require only one diagonalization per time step and are applicable to a broader range of materials with improved accuracy and stability compared to previous formulations

  10. Particle detection technology for space-borne astroparticle experiments

    CERN Document Server

    Pohl, Martin

    2014-01-01

    I review the transfer of technology from accelerator-based equipment to space-borne astroparticle detectors. Requirements for detection, identification and measurement of ions, electrons and photons in space are recalled. The additional requirements and restrictions imposed by the launch process in manned and unmanned space flight, as well as by the hostile environment in orbit, are analyzed. Technology readiness criteria and risk mitigation strategies are reviewed. Recent examples are given of missions and instruments in orbit, under construction or in the planning phase.

  11. Minimization of structure-borne noise in lightweight buildings

    DEFF Research Database (Denmark)

    Niu, Bin; Olhoff, Niels

    2012-01-01

    This paper deals with the problem of minimizing the structure-borne noise induced in a room by machinery vibration. A generalized system consisting of the machine, the base plate, resilient mounts, the floor plate and the room cavity is developed for analysis and optimization. Topological design of...... the base plate is studied for optimizing machinery installation. Furthermore, periodic mounts are optimized for the noise reduction. Finally, a modular model of a lightweight building is developed for design optimization of dimensions and connections of modules in the building for decreasing machinery...... vibration transmission....

  12. Balloon-borne video cassette recorders for digital data storage

    International Nuclear Information System (INIS)

    A high-speed, high-capacity digital data storage system has been developed for a new balloon-borne gamma-ray telescope. The system incorporates sophisticated, yet easy to use and economical consumer products: the portable video cassette recorder (VCR) and a relatively newer item - the digital audio processor. The in-flight recording system employs eight VCRs and will provide a continuous data storage rate of 1.4 megabits/sec throughout a 40 hour balloon flight. Data storage capacity is 25 gigabytes and power consumption is only 10 watts

  13. Non-BPS Dirac-Born-Infeld Solitons

    OpenAIRE

    Ioannidou, Theodora; Papadopoulos, George; Sutcliffe, Paul(Department of Mathematical Sciences, Durham University, South Road, Durham, DH1 3LE, U.K.)

    1999-01-01

    We show that CPn sigma model solitons solve the field equations of a Dirac-Born-Infeld (DBI) action and, furthermore, we prove that the non-BPS soliton/anti-soliton solutions of the sigma model also solve the DBI equations. Using the moduli space approximation we compare the dynamics of the BPS sigma model solitons with that of the associated DBI solitons. We find that for the CP1 case the metric on the moduli space of sigma model solitons is identical to that of the moduli space of DBI solit...

  14. Nativity concentration and internal migration among the foreign-born.

    Science.gov (United States)

    Kritz, M M; Nogle, J M

    1994-08-01

    Are immigrants who live in states where large numbers of their compatriots reside more or less likely to migrate than those who live in other states? Using 1980 U.S. Census data to address that question, the analysis shows that nativity concentration deters interstate migration but not migration within the same state. Residing in a state where fellow nationals live is a more important determinant of internal migration than human capital, immigration status, or a state's unemployment rate. New York State residence in 1975 also promotes interstate migration. This research suggests that social dimensions should be taken into account in modeling internal migration of the foreign-born. PMID:7828769

  15. A Recursive Born Approach to Nonlinear Inverse Scattering

    CERN Document Server

    Kamilov, Ulugbek S; Mansour, Hassan; Boufounos, Petros T

    2016-01-01

    The Iterative Born Approximation (IBA) is a well-known method for describing waves scattered by semi-transparent objects. In this paper, we present a novel nonlinear inverse scattering method that combines IBA with an edge-preserving total variation (TV) regularizer. The proposed method is obtained by relating iterations of IBA to layers of a feedforward neural network and developing a corresponding error backpropagation algorithm for efficiently estimating the permittivity of the object. Simulations illustrate that, by accounting for multiple scattering, the method successfully recovers the permittivity distribution where the traditional linear inverse scattering fails.

  16. Spatial model for transmission of mosquito-borne diseases

    Science.gov (United States)

    Kon, Cynthia Mui Lian; Labadin, Jane

    2015-05-01

    In this paper, a generic model which takes into account spatial heterogeneity for the dynamics of mosquito-borne diseases is proposed. The dissemination of the disease is described by a system of reaction-diffusion partial differential equations. Host human and vector mosquito populations are divided into susceptible and infectious classes. Diffusion is considered to occur in all classes of both populations. Susceptible humans are infected when bitten by infectious mosquitoes. Susceptible mosquitoes bite infectious humans and become infected. The biting rate of mosquitoes is considered to be density dependent on the total human population in different locations. The system is solved numerically and results are shown.

  17. European activities in balloon-borne infrared astronomy

    International Nuclear Information System (INIS)

    Infrared and submillimeter astronomy contributes essentially to the understanding of basic astrophysical processes (e.g. formation and evolution of stars and galaxies, origin of the universe). Atmospheric emission and absorption place severe constraints on the wavelength range and sensitivity of corresponding ground-based measurements. Since no infrared astronomical satellite is in operation yet, balloon-borne instruments are the ones with the highest sensitivity. Approximately ten European groups are active in this field and have produced important scientific results within the last ten years. Their work can be divided into four groups: investigation of the solar system; stellar evolution; galactic evolution and origin of the universe. (Auth.)

  18. The Neutron Star Born in the Antlia Supernova Remnant

    OpenAIRE

    Tetzlaff, Nina; Torres, Guillermo; Neuhaeuser, Ralph; Hohle, Markus Matthias

    2013-01-01

    Among all known young nearby neutron stars, we search for the neutron star that was born in the same supernova event that formed the Antlia supernova remnant (SNR). We also look for a runaway star that could have been the former companion to the neutron star (if it exists) and then got ejected due to the same supernova. We find the pulsar PSR J0630-2834 to be the best candidate for a common origin with the Antlia SNR. In that scenario the SNR is ~1.2 Myr old and is presently located at a dist...

  19. A stellar endgame -- the born-again Sakurai's object

    OpenAIRE

    Asplund, M.; Gustafsson, B.; Lambert, D. L.; Rao, N. K.

    1997-01-01

    The surface chemical composition of this remarkable star shows that it is hydrogen-deficient, carbon-rich and enriched in the light s-process elements. Spectra taken in May and October 1996 indicate a decrease in the surface hydrogen abundance by 0.7 dex in five months along with an increase in the abundances of Li, Sr, Y and Zr. The abundance changes are in agreement with the hypothesis of the star being a rapidly evolving ``born-again'' AGB star experiencing a final He-shell flash, similar ...

  20. Matrix Theory Star Products from the Born-Infeld Action

    OpenAIRE

    Cornalba, Lorenzo; Schiappa, Ricardo

    1999-01-01

    We conjecture that the Sen-Seiberg limit of the Type IIA D2-brane action in a flat spacetime background can be resummed, at all orders in \\alpha', to define an associative star product on the membrane. This star product can be independently constrained from the equivalent Matrix theory description of the corresponding M2-brane, by carefully analyzing the known BPS conditions. Higher derivative corrections to the Born-Infeld action on the IIA side are reinterpreted, after the Sen-Seiberg limit...

  1. Tick-Borne Relapsing Fever Spirochetes in the Americas

    Directory of Open Access Journals (Sweden)

    Job E. Lopez

    2016-08-01

    Full Text Available Relapsing fever spirochetes are tick- and louse-borne pathogens that primarily afflict those in impoverished countries. Historically the pathogens have had a significant impact on public health, yet currently they are often overlooked because of the nonspecific display of disease. In this review, we discuss aspects of relapsing fever (RF spirochete pathogenesis including the: (1 clinical manifestation of disease; (2 ability to diagnose pathogen exposure; (3 the pathogen’s life cycle in the tick and mammal; and (4 ecological factors contributing to the maintenance of RF spirochetes in nature.

  2. Molecular epidemiology of two international sprout-borne Salmonella outbreaks.

    OpenAIRE

    Puohiniemi, R; Heiskanen, T.; Siitonen, A.

    1997-01-01

    Sprout-borne Salmonella outbreaks in Finland have increased during the last 10 years. The latest two were caused by Salmonella enterica serovar Bovismorbificans (antigenic structure 6,8:r:1,5) in 1994 and S. enterica serovar Stanley (4,5, 12:d:1,2) in 1995. In this study, the restriction fragment length polymorphism of genomic DNA after pulsed-field gel electrophoresis (PFGE) and antimicrobial resistance profiles of the outbreak and nonoutbreak strains were compared. In each separate outbreak...

  3. Pointing System for the Balloon-Borne Astronomical Payloads

    CERN Document Server

    Nirmal, K; Mathew, Joice; Sarpotdar, Mayuresh; Suresh, Ambily; Prakash, Ajin; Safonova, Margarita; Murthy, Jayant

    2016-01-01

    We describe the development and implementation of a light-weight, fully autonomous 2-axis pointing and stabilization system designed for balloon-borne astronomical payloads. The system is developed using off-the-shelf components such as Arduino Uno controller, HMC 5883L magnetometer, MPU-9150 Inertial Measurement Unit (IMU) and iWave GPS receiver unit. It is a compact and rugged system which can also be used to take images/video in a moving vehicle, or in areal photography. The system performance is evaluated from the ground, as well as in conditions simulated to imitate the actual flight by using a tethered launch.

  4. Air-borne contact dermatitis caused exclusively by xanthium strumarium

    Directory of Open Access Journals (Sweden)

    Pasricha J

    1995-01-01

    Full Text Available Most cases having air-borne contact dermatitis (ABCD in India are considered to be caused by Parthenium hysterophorus. In some cases however, other plants have also been noticed to give positive patch test reactions. We are reporting two cases presenting as ABCD who showed positive patch tests with Xanthium strumarium while the patch tests with Parthenium hysterophorus were negative. It is therefore necessary to realise that every case of ABCD is not caused by Parthenium, and patch testing with Parthenium alone can lead to serious mistakes.

  5. Air-borne contact dermatitis caused exclusively by xanthium strumarium.

    Science.gov (United States)

    Pasricha, J S; Verma, K K; D'Souza, P

    1995-01-01

    Most cases having air-borne contact dermatitis (ABCD) in India are considered to be caused by Parthenium hysterophorus. In some cases however, other plants have also been noticed to give positive patch test reactions. We are reporting two cases presenting as ABCD who showed positive patch tests with Xanthium strumarium while the patch tests with Parthenium hysterophorus were negative. It is therefore necessary to realise that every case of ABCD is not caused by Parthenium, and patch testing with Parthenium alone can lead to serious mistakes. PMID:20953020

  6. Computed tomography of the head of new born premature infants

    International Nuclear Information System (INIS)

    Evaluation of the extracerebral space on CT resulted as follows: The existence of the etracerebral space in the parieto-occipital region (PO-ECS) was physiological findings characteristic to premature infants. Its incidence was higher and the width of the space was greater, in those of premature infants. Generally PO-ECS disappeared around 40 weeks of gestation, while it tended to remaine beyond 40 weeks in premature infants born after less than 30 weeks of pregnancy. The appearance and disappearance of the PO-ECS may present some approach to learning the development of the brain in premature infants. (Ueda, J.)

  7. ShoreZone Survey Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset is a point file showing GPS trackline data collected during a ShoreZone aerial imaging survey. This flight trackline is recorded at 1-second intervals...

  8. Offshore Wind Technology Depth Zones

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Coastal bathymetric depth, measured in meters at depth values of: -30, -60, -900 Shallow Zone (0-30m): Technology has been demonstrated on a commercial scale at...

  9. NEPR Geographic Zone Map 2015

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This geographic zone map was created by interpreting satellite and aerial imagery, seafloor topography (bathymetry model), and the new NEPR Benthic Habitat Map...

  10. Development Zones Flourish in Beijing

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ Based on the Beijing Municipal Government's plans for developing the city and neighboring suburbs,and after more than 10 years in development,the Beijing Development Zones have taken shape,each with their own characteristics.

  11. The Balloon-Borne Exoplanet Experiment (EchoBeach)

    Science.gov (United States)

    Pascale, E.

    2013-09-01

    The Balloon-Borne Exoplanet Experiment (EchoBeach) is a proposed sub-orbital spectroscopic instrument. Its primary scientific goal is to detect and characterize the atmospheres of transiting exoplanets in the Mid-IR part of the electromagnetic spectrum from 4 to 20 μm using a 1.6m diameter telescope. It is in this wavelength range where the contrast between the star and planet emission grows exponentially, and this spectral region is key to answering important questions about the existence and composition of exp-atmospheres. Due to the Earth atmospheric absorption and emission, bservations at these wavelength are impossible from the ground or even at aircraft altitudes, but become available to balloon-born instrumentation flying in the upper stratosphere. At present we have high fidelity Mid-IR spectra of just two exoplanets of any type. EchoBeach can greatly improve on this by observing a multitude of transiting exoplanets, well in advance of any planned space-mission.

  12. Stability of a Tick-Borne Flavivirus in Milk

    Science.gov (United States)

    Offerdahl, Danielle K.; Clancy, Niall G.; Bloom, Marshall E.

    2016-01-01

    The tick-borne flaviviruses (TBFV) occur worldwide and the tick-borne encephalitis virus (TBEV) members of the group often cause severe, debilitating neurological disease in humans. Although the primary route of infection is through the bite of an infected tick, alimentary infection through the consumption of TBEV-contaminated dairy products is also well-documented and is responsible for some disease in endemic areas. Experimental infection of goats, cattle, and sheep with TBEV shows that the virus can be excreted in the milk of infected animals. Additionally, the virus remains infectious after exposure to low pH levels, similar to those found in the stomach. To evaluate the survival of virus in milk, we studied the stability of the BSL-2 TBFV, Langat virus, in unpasteurized goat milk over time and after different thermal treatments. Virus was stable in milk maintained under refrigeration conditions; however, there was a marked reduction in virus titer after incubation at room temperature. High temperature, short time pasteurization protocols completely inactivated the virus. Interestingly, simulation of a typical thermal regime utilized for cheese did not completely inactivate the virus in milk. These findings stress the importance of proper milk handling and pasteurization processes in areas endemic for TBEV.

  13. On the mathematical treatment of the Born-Oppenheimer approximation

    Energy Technology Data Exchange (ETDEWEB)

    Jecko, Thierry, E-mail: thierry.jecko@u-cergy.fr [AGM, UMR 8088 du CNRS, Université de Cergy-Pontoise, Département de mathématiques, site de Saint Martin, 2 avenue Adolphe Chauvin, F-95000 Pontoise (France)

    2014-05-15

    Motivated by the paper by Sutcliffe and Woolley [“On the quantum theory of molecules,” J. Chem. Phys. 137, 22A544 (2012)], we present the main ideas used by mathematicians to show the accuracy of the Born-Oppenheimer approximation for molecules. Based on mathematical works on this approximation for molecular bound states, in scattering theory, in resonance theory, and for short time evolution, we give an overview of some rigorous results obtained up to now. We also point out the main difficulties mathematicians are trying to overcome and speculate on further developments. The mathematical approach does not fit exactly to the common use of the approximation in Physics and Chemistry. We criticize the latter and comment on the differences, contributing in this way to the discussion on the Born-Oppenheimer approximation initiated by Sutcliffe and Woolley. The paper neither contains mathematical statements nor proofs. Instead, we try to make accessible mathematically rigourous results on the subject to researchers in Quantum Chemistry or Physics.

  14. Dualities in M-theory and Born-Infeld Theory

    Energy Technology Data Exchange (ETDEWEB)

    Brace, Daniel, M

    2001-08-01

    We discuss two examples of duality. The first arises in the context of toroidal compactification of the discrete light cone quantization of M-theory. In the presence of nontrivial moduli coming from the M-theory three form, it has been conjectured that the system is described by supersymmetric Yang-Mills gauge theory on a noncommutative torus. We are able to provide evidence for this conjecture, by showing that the dualities of this M-theory compactification, which correspond to T-duality in Type IIA string theory, are also dualities of the noncommutative supersymmetric Yang-Mills description. One can also consider this as evidence for the accuracy of the Matrix Theory description of M-theory in this background. The second type of duality is the self-duality of theories with U(1) gauge fields. After discussing the general theory of duality invariance for theories with complex gauge fields, we are able to find a generalization of the well known U(1) Born-Infeld theory that contains any number of gauge fields and which is invariant under the maximal duality group. We then find a supersymmetric extension of our results, and also show that our results can be extended to find Born-Infeld type actions in any even dimensional spacetime.

  15. White matter and cognition in adults who were born preterm.

    Directory of Open Access Journals (Sweden)

    Matthew P G Allin

    Full Text Available BACKGROUND AND PURPOSE: Individuals born very preterm (before 33 weeks of gestation, VPT are at risk of damage to developing white matter, which may affect later cognition and behaviour. METHODS: We used diffusion tensor MRI (DT-MRI to assess white matter microstructure (fractional anisotropy; FA in 80 VPT and 41 term-born individuals (mean age 19.1 years, range 17-22, and 18.5 years, range 17-22 years, respectively. VPT individuals were part of a 1982-1984 birth cohort which had been followed up since birth; term individuals were recruited by local press advertisement. General intellectual function, executive function and memory were assessed. RESULTS: The VPT group had reduced FA in four clusters, and increased FA in four clusters relative to the Term group, involving several association tracts of both hemispheres. Clusters of increased FA were associated with more severe neonatal brain injury in the VPT group. Clusters of reduced FA were associated with lower birth weight and perinatal hypoxia, and with reduced adult cognitive performance in the VPT group only. CONCLUSIONS: Alterations of white matter microstructure persist into adulthood in VPT individuals and are associated with cognitive function.

  16. HOW CAN NEWLY BORN RAPIDLY ROTATING NEUTRON STARS BECOME MAGNETARS?

    International Nuclear Information System (INIS)

    In a newly born (high-temperature and Keplerian rotating) neutron star, r-mode instability can lead to stellar differential rotation, which winds the seed poloidal magnetic field (∼1011 G) to generate an ultra-high (∼1017 G) toroidal field component. Subsequently, by succumbing to the Tayler instability, the toroidal field could be partially transformed into a new poloidal field. Through such dynamo processes, the newly born neutron star with sufficiently rapid rotation could become a magnetar on a timescale of ∼102 – 3 s, with a surface dipolar magnetic field of ∼1015 G. Accompanying the field amplification, the star could spin down to a period of ∼5 ms through gravitational wave radiation due to the r-mode instability and, in particular, the non-axisymmetric stellar deformation caused by the toroidal field. This scenario provides a possible explanation for why the remnant neutron stars formed in gamma-ray bursts and superluminous supernovae could be millisecond magnetars

  17. NEWLY BORN PULSARS AS SOURCES OF ULTRAHIGH ENERGY COSMIC RAYS

    International Nuclear Information System (INIS)

    Newly born pulsars offer favorable sites for the injection of heavy nuclei, and for their further acceleration to ultrahigh energies. Once accelerated in the pulsar wind, nuclei have to escape from the surrounding supernova envelope. We examine this escape analytically and numerically and discuss the pulsar source scenario in light of the latest ultrahigh energy cosmic ray (UHECR) data. Our calculations show that, at early times, when protons can be accelerated to energies E > 1020 eV, the young supernova shell tends to prevent their escape. In contrast, because of their higher charge, iron-peaked nuclei are still accelerated to the highest observed energies at later times, when the envelope has become thin enough to allow their escape. Ultrahigh energy iron nuclei escape newly born pulsars with millisecond periods and dipole magnetic fields of ∼1012-1013 G, embedded in core-collapse supernovae. Due to the production of secondary nucleons, the envelope crossing leads to a transition of composition from light to heavy elements at a few EeV, as observed by the Auger Observatory. The escape also results in a softer spectral slope than that initially injected via unipolar induction, which allows for a good fit to the observed UHECR spectrum. We conclude that the acceleration of iron-peaked elements in a reasonably small fraction (∼< 0.01%) of extragalactic rotation-powered young pulsars would reproduce satisfactorily the current UHECR data. Possible signatures of this scenario are also discussed.

  18. Tick-borne infections in human and animal population worldwide

    Directory of Open Access Journals (Sweden)

    José Brites-Neto

    2015-03-01

    Full Text Available The abundance and activity of ectoparasites and its hosts are affected by various abiotic factors, such as climate and other organisms (predators, pathogens and competitors presenting thus multiples forms of association (obligate to facultative, permanent to intermittent and superficial to subcutaneous developed during long co-evolving processes. Ticks are ectoparasites widespread globally and its eco epidemiology are closely related to the environmental conditions. They are obligatory hematophagous ectoparasites and responsible as vectors or reservoirs at the transmission of pathogenic fungi, protozoa, viruses, rickettsia and others bacteria during their feeding process on the hosts. Ticks constitute the second vector group that transmit the major number of pathogens to humans and play a role primary for animals in the process of diseases transmission. Many studies on bioecology of ticks, considering the information related to their population dynamics, to the host and the environment, comes possible the application and efficiency of tick control measures in the prevention programs of vector-borne diseases. In this review were considered some taxonomic, morphological, epidemiological and clinical fundamental aspects related to the tick-borne infections that affect human and animal populations.

  19. Long-term outcomes in children born after assisted conception.

    Science.gov (United States)

    Eisenberg, Esther

    2012-04-01

    Millions of children have been born worldwide through assisted reproductive technology (ART), and access is increasing yearly. Our current knowledge and understanding of the long-term risks and/or benefits to the children conceived is incomplete. Investigations of the health, disease, cognitive, developmental, and behavioral outcomes are often confounded by other factors, including multiple gestations, prematurity, and low birthweight. Reports of the long-term health and psychosocial adjustment of children conceived with ART show generally good outcomes. Many of the major long-term problems observed in the children may be associated with multiple gestations, preterm delivery, and low birthweight or with subfertility of the parents. Evidence in the male infants conceived with the aid of intracytoplasmic sperm injection suggests an increased risk of reproductive tract anomalies such as hypospadias. Outcome data on health of children born after cryopreservation of cleavage stage embryos are reassuring. Measuring long-term outcomes is the first step to improving and optimizing health in the offspring conceived with medical and technological assistance. PMID:22549712

  20. Stability of a tick-borne flavivirus in milk

    Directory of Open Access Journals (Sweden)

    Danielle K Offerdahl

    2016-05-01

    Full Text Available The tick-borne flaviviruses (TBFV occur worldwide and the tick-borne encephalitis virus members of the group (TBEV often cause severe, debilitating neurological disease in humans. Although the primary route of infection is through the bite of an infected tick, alimentary infection through the consumption of TBEV-contaminated dairy products is also well-documented and is responsible for some disease in endemic areas. Experimental infection of goats, cattle, and sheep with TBEV shows that virus can be excreted in the milk of infected animals. Additionally, the virus remains infectious after exposure to low pH levels, similar to those found in the stomach. To evaluate survival of virus in milk, we studied the stability of the BSL-2 TBFV, Langat virus, in unpasteurized goat milk over time and after different thermal treatments. Virus was stable in milk maintained under refrigeration conditions; however, there was a marked reduction in virus titer after incubation at room temperature. High temperature, short time pasteurization protocols completely inactivated the virus. Interestingly, simulation of a typical thermal regime utilized for cheese did not completely inactivate the virus in milk. These findings stress the importance of proper milk handling and pasteurization processes in areas endemic for TBEV.

  1. THE ROLE OF INTERNET IN THE BORN GLOBAL COMPANIES

    Directory of Open Access Journals (Sweden)

    Marcus Vinicius de Oliveira Brasil

    2013-06-01

    Full Text Available The process of internationalization of global companies occurs connected to the high integration through the nets of computers, especially the Internet. The technological advances have revolutionized the forms of transacting products and services. Innovation becomes the key word for this new phase established in the economy by the computer science in which the Internet is able to establish a larger integration among the enterprises, consumers and suppliers. How can the Internet contribute to the process of Internationalization of Born Globals? This theoretical paper aims to discuss the role of innovations with internet in Born Globals firms to the process of internationalization. The literature review on the subject shows that the advances of technology will require new studies about the internationalization’s process. In spite of that, the influence of the electronic business has progressed in commercial transactions. The global world requires workers who are more and more prepared to face such reality. The enterprises will have to adapt, otherwise they may fail to reduce costs and to improve their logistics. The consumers can have personalized products, while their needs are met in a more comfortable, immediate way and with less intermediates. The electronic markets revolutionize the economy by meeting old needs in a more modern and practical way.

  2. Born in Bradford, a cohort study of babies born in Bradford, and their parents: Protocol for the recruitment phase

    Directory of Open Access Journals (Sweden)

    Raynor Pauline

    2008-09-01

    Full Text Available Abstract Background Bradford, one of the most deprived cities in the United Kingdom, has a wide range of public health problems associated with socioeconomic deprivation, including an infant mortality rate almost double that for England and Wales. Infant mortality is highest for babies of Pakistani origin, who comprise almost half the babies born in Bradford. The Born in Bradford cohort study aims to examine environmental, psychological and genetic factors that impact on health and development perinatally, during childhood and subsequent adult life, and those that influence their parents' health and wellbeing. This protocol outlines methods for the recruitment phase of the study. Methods Most Bradford women attend for antenatal care and give birth at the Bradford Royal Infirmary, which has approximately 5,800 births per year. Women are eligible for recruitment if they plan to give birth here. Babies born from March 2007 are eligible to participate, recruitment is planned to continue until 2010. Fathers of babies recruited are invited to participate. Women are usually recruited when they attend for a routine oral glucose tolerance test at 26–28 weeks gestation. Recruitment of babies is at birth. Fathers are recruited whenever possible during the antenatal period, or soon after the birth. The aim is to recruit 10,000 women, their babies, and the babies' fathers. At recruitment women have blood samples taken, are interviewed to complete a semi-structured questionnaire, weighed, and have height, arm circumference and triceps skinfold measured. Umbilical cord blood is collected at birth. Within two weeks of birth babies have their head, arm and abdominal circumference measured, along with subscapular and triceps skinfold thickness. Fathers self-complete a questionnaire at recruitment, have height and weight measured, and provide a saliva sample. Participants are allocated a unique study number. NHS numbers will be used to facilitate record linkage

  3. Stepped conical zone plate antenna

    Science.gov (United States)

    Wiltse, James C.

    2001-07-01

    The Fresnel zone plate lens was invented and developed for optical frequencies. However, fabrication difficulties at the short optical wavelengths have prevented obtain good efficiencies. At longer microwave or millimeter-wavelengths fabrication is easier and phase correcting zone plate antennas have been used to obtain good efficiencies. This paper describes a new type of phase correcting zone plate having even better efficiency, namely a diffraction efficiency of 99 percent compared to a true lens, and an overall efficiency much better than a true lens. For the usual zone plate antenna employed at microwave or millimeter wavelengths, path length adjustment is accomplished by cutting different depths in a dielectric plate or by using two or more dielectrics having different dielectric constants. The new design uses a tilted cut in a dielectric plate, which more accurately matches the shape of a true lens and produces much lower phase error. The construction is still near and can be made for example, by a milling machine with a tilted bit. For a circular zone plate, the lens is a stepped conical or tapered shape. Because the phase steps are small, the far-field antenna pattern is excellent and sidelobe-levels are very low. Analysis of typical configurations will be given, showing that phase errors are small, lower than those for an eighth-wave corrected phase zone plate.

  4. Understanding the Fluvial Critical Zone

    Science.gov (United States)

    Bätz, N.; Lane, S. N.; Temme, A. J. A. M.; Lang, F.

    2012-04-01

    Geomorphological modelling has evolved significantly the representation of the link between river morphology, flow processes and sediment transport; notably recently, with an emphasis upon the interactions between vegetation dynamics and morphodynamics. Nevertheless, vegetation dynamics have tended to be treated as a simplistic "black box" in which time replaces the more complex underlying processes. Thus, riparian vegetation dynamics not only result from interactions between surface-flow, topography and vegetation resistance to disturbance, but also soil development within the fluvial zone, which affects nutrient and water supply. More generally labeled the critical zone, there is a lack of considering the "critical fluvial zone" in geomorphological models. Understanding the key drivers of this system, thus the processes interrelating vegetation, topography, soil (formation), subsurface- and surface-flow, are crucial to understand how riverine landscapes respond to increasing human pressure and to climate change. In this poster, we consider the likely nature of a braided river critical fluvial zone. Braided rivers in deglaciated forelands provide an opportunity to study the fluvial critical zone due to their dynamic properties, the restricted physical size, the simple ecosystems and the space-for-time relation caused by glacier retreatment after the "Little Ice Age". The poster aims to commence a discussion on the fluvial critical zone, showing first results about: a) the system understanding of a braided river set in a recently deglaciated alpine foreland; b) methodological approaches to quantify the identified interrelating key processes; c) how quantitative understanding can be integrated into fluvial geomorphological modelling.

  5. Content and the forms of heavy metals in bottom sediments in the zone of industrial pollution sources ,

    OpenAIRE

    Voytyuk Y.Y.; Kurayeva I.V.; Kroyik H.A.; Karmazynenko S.P.; Matsibora O.V.

    2014-01-01

    Regularities in the distribution of heavy metals in sediments in the zone of influence of the steel industry in Mariupol are installed. The study results of the forms of occurrence of Zn, Pb, Cu, Cr, Ni are represented. Ecological and geochemical assessment of sediment contamination by heavy metals is performed. The main sources of pollution of bottom sediments are air borne emissions from industrial plants, hydrogenous pollution in industrial sewage entering the water, sewage sludge, ash dum...

  6. The galactic habitable zone of the Milky Way and M31 from chemical evolution models with gas radial flows

    CERN Document Server

    Spitoni, E; Sozzetti, A

    2014-01-01

    The galactic habitable zone is defined as the region with sufficient abundance of heavy elements to form planetary systems in which Earth-like planets could be born and might be capable of sustaining life, after surviving to close supernova explosion events. Galactic chemical evolution models can be useful for studying the galactic habitable zones in different systems. We apply detailed chemical evolution models including radial gas flows to study the galactic habitable zones in our Galaxy and M31. We compare the results to the relative galactic habitable zones found with "classical" (independent ring) models, where no gas inflows were included. For both the Milky Way and Andromeda, the main effect of the gas radial inflows is to enhance the number of stars hosting a habitable planet with respect to the "classical" model results, in the region of maximum probability for this occurrence, relative to the classical model results. These results are obtained by taking into account the supernova destruction process...

  7. Born modeling for heterogeneous media using the Gaussian beam summation based Green's function

    Science.gov (United States)

    Huang, Xingguo; Sun, Hui; Sun, Jianguo

    2016-08-01

    Born approximation is a commonly used approximation in the simulation of seismic wave propagation. Calculation of the Green's function in Born approximation integral is essential for Born modeling. We derive a new Born formula based on the Gaussian beam representations of Green's functions. This procedure can be used to mitigate the problems like the caustic, shadow region, and multivalued traveltime caused by multipathing that traditional geometric ray theory cannot deal with. However, due to the characteristic of complex traveltime in the Gaussian beam, we present a new isochronous stack method for Gaussian beam based Born modeling. Additionally, two basic issues, background velocity and integral region selection, are discussed. Numerical results demonstrate the accuracy and efficiency of the Gaussian beam based Born theory and implementation.

  8. WAS THE SUN BORN IN A MASSIVE CLUSTER?

    International Nuclear Information System (INIS)

    A number of authors have argued that the Sun must have been born in a cluster of no more than several thousand stars, on the basis that, in a larger cluster, close encounters between the Sun and other stars would have truncated the outer solar system or excited the outer planets into eccentric orbits. However, this dynamical limit is in tension with meteoritic evidence that the solar system was exposed to a nearby supernova during or shortly after its formation; a several-thousand-star cluster is much too small to produce a massive star whose lifetime is short enough to have provided the enrichment. In this paper, we revisit the dynamical limit in the light of improved observations of the properties of young clusters. We use a series of scattering simulations to measure the velocity-dependent cross-section for disruption of the outer solar system by stellar encounters, and use this cross-section to compute the probability of a disruptive encounter as a function of birth cluster properties. We find that, contrary to prior work, the probability of disruption is small regardless of the cluster mass, and that it actually decreases rather than increases with cluster mass. Our results differ from prior work for three main reasons: (1) unlike in most previous work, we compute a velocity-dependent cross-section and properly integrate over the cluster mass-dependent velocity distribution of incoming stars; (2) we recognize that ∼90% of clusters have lifetimes of a few crossing times, rather than the 10-100 Myr adopted in many earlier models; and (3) following recent observations, we adopt a mass-independent surface density for embedded clusters, rather than a mass-independent radius as assumed many earlier papers. Our results remove the tension between the dynamical limit and the meteoritic evidence, and suggest that the Sun was born in a massive cluster. A corollary to this result is that close encounters in the Sun's birth cluster are highly unlikely to truncate the

  9. Investigation on Satellite-borne High-power Solid-state Power Amplifier Technology and Experiment

    OpenAIRE

    Wu Xiao-po; Zhao Hai-yang; Xi Song-tao

    2014-01-01

    Based on the research and development efforts of satellite-borne lumped solid-state transmitters, the design of a satellite-borne high-power microwave amplifier module is introduced. Focusing on satellite-borne applications, aspects of the high-power density thermal design, multipactor proof design, EMC design and so on, which are critical technologies for a solid-state power amplifier, are discussed. Subsequently, experiments are used to verify the concept.

  10. Investigation on Satellite-borne High-power Solid-state Power Amplifier Technology and Experiment

    Directory of Open Access Journals (Sweden)

    Wu Xiao-po

    2014-06-01

    Full Text Available Based on the research and development efforts of satellite-borne lumped solid-state transmitters, the design of a satellite-borne high-power microwave amplifier module is introduced. Focusing on satellite-borne applications, aspects of the high-power density thermal design, multipactor proof design, EMC design and so on, which are critical technologies for a solid-state power amplifier, are discussed. Subsequently, experiments are used to verify the concept.

  11. Variables influencing survival in four generations of captive-born muskoxen

    OpenAIRE

    Lent, P.C.; Davis, W J

    1993-01-01

    Since 1967, four generations of muskoxen have been born in captivity in Alaska (399 live births, 18 abortions and 47 stillbirths), all derived from 20 females and 8 males captured on Nunivak Island. Analysis of juvenile survival was accomplished by dividing individuals into 7 classes (not born live, born live but not surviving 48 hours, survived 48 hours but < 1 week, survived 1 week but < 1 month, survived 1 month but < 6 months, survived 6 months but < 2 years, survived 2 years)...

  12. Staphylococcus aureus and Staphylococcal Food-Borne Disease: An Ongoing Challenge in Public Health

    OpenAIRE

    Jhalka Kadariya; Smith, Tara C.; Dipendra Thapaliya

    2014-01-01

    Staphylococcal food-borne disease (SFD) is one of the most common food-borne diseases worldwide resulting from the contamination of food by preformed S. aureus enterotoxins. It is one of the most common causes of reported food-borne diseases in the United States. Although several Staphylococcal enterotoxins (SEs) have been identified, SEA, a highly heat-stable SE, is the most common cause of SFD worldwide. Outbreak investigations have found that improper food handling practices in the retail ...

  13. Growth phases and survival of born globals - Case: Finnish software firms

    OpenAIRE

    Hashimoto, Shiho

    2011-01-01

    Objectives of the Research This study was part of the “Born Global Growth and Survival” joint project by Aalto University School of Economics and University of Vaasa. Based on a literature review and an empirical research, the growth phases of Born Global firms and factors that influence the growth and survival of these firms are introduced. This particular thesis contributes by focusing specifically on the Born Global firms in the software business. The literature review covers such t...

  14. The Effects of Human Movement on the Persistence of Vector-Borne Diseases*

    OpenAIRE

    C. Cosner; Beier, J. C.; Cantrell, R. S.; Impoinvil, D.; Kapitanski, L.; Potts, M. D.; Troyo, A.; S. Ruan

    2009-01-01

    With the recent resurgence of vector-borne diseases due to urbanization and development there is an urgent need to understand the dynamics of vector-borne diseases in rapidly changing urban environments. For example, many empirical studies have produced the disturbing finding that diseases continue to persist in modern city centers with zero or low rates of transmission. We develop spatial models of vector-borne disease dynamics on a network of patches to examine how the movement of humans in...

  15. Eddington-Born-Infeld action for dark energy and dark matter

    OpenAIRE

    Banados, Maximo

    2008-01-01

    We argue that Einstein gravity coupled to a Born-Infeld theory provides an attractive candidate to represent dark matter and dark energy. For cosmological models, the Born-Infeld field has an equation of state which interpolates between matter, w=0 (small times), and a cosmological constant w=-1 (large times). On galactic scales, the Born-Infeld field predicts asymptotically flat rotation curves.

  16. Violation of the Born Rule: Implications for the Classical Electromagnetic Field

    OpenAIRE

    Kastner, R. E.

    2016-01-01

    It is shown that violation of the Born Rule leads to a breakdown of the correspondence between the quantum electromagnetic field and its classical counterpart. Specifically, the relationship of the quantum coherent state to the classical electromagnetic field turns out to imply that if the Born Rule were violated, this could result in apparent deviations from the energy conservation law applying to the field and its sources (Poynting's Theorem). The result suggests that the Born Rule is just ...

  17. Ecommerce drivers and marketing partnerships in successful export marketing of Finnish born globals

    OpenAIRE

    Penttinen, Jukka

    2015-01-01

    This study examines the utilization of ecommerce and marketing partnerships as part of born global internationalization strategies. The study will combine the existing literature of born global internationalization, export marketing strategies and ecommerce as part of internationalization to form an understanding on how two Finnish health and welfare sector born globals internationalize, and how ecommerce drivers affect their internationalization. Because of the explorative nature of the stud...

  18. Globalization of Finnish ICT Born Globals: Creating new market space with disruptive innovation strategy

    OpenAIRE

    Myllymäki, Arttu

    2010-01-01

    ABSTRACT Objective Objective of this Master’s thesis is to research Finnish ICT Born Global companies that have globalized their operations leveraging disruptive technologies and how disruptive innovation influences the globalization? This topic has become increasingly relevant as many Born Globals do in fact, leverage disruptive innovation as a strategic approach. However, Born Global theory has not really been approached previously from the this type of value innovation perspective ...

  19. Genetic aftermath of the Chernobyl accident in the populations of Byelorus zones

    International Nuclear Information System (INIS)

    Since the Chernobyl nuclear accident, various long-term surveys have been made on congenital malformations, abnormal embryos and fetuses, multiple congenital malformations and others in Byelorus zones. This report introduces the outcome of these surveys. Legal abortuses at the gestation of 5-12 weeks and newborns were reviewed for teratogenetic and mutagenic analyses. Approximately 50 kinds of abnormal diseases were observed in legal abortuses; urogenital system disease was the most common, followed by gastrointestinal and neurological diseases. There was no significant difference in malformation frequency in legal abortuses in Minsk and Gomel before and after the Chernobyul accident. There was neither specific teratogenetic effect nor fetus growth that was thought to be attributed to radiation exposure directly due to the Chernobyl accident. However, the incidence (per 1000 deliveries) of children born with obligatory registered malformations was increased in all Byelorus zones. This tendency was noticeable especially in the newborn born in the zone of cesium-137 of 15 Ci/km2 (555 kBq/m2), which was much more than that expected by the ICRP. The correlation between some congenital malformations and ionizing radiation has been shown only indirectly by an increase in dominant hereditary abnormality in the contaminated areas. Further collection of materials, registration and statistical analysis will provide more reliable information to evaluate genetic aftermath of the Chernobyl accident objectively. (N.K.)

  20. Profile of tuberculosis among the foreign-born population in Japan, 2007–2014

    Science.gov (United States)

    Uchimura, Kazuhiro; Izumi, Kiyohiko; Ohkado, Akihiro; Ishikawa, Nobukatsu

    2016-01-01

    The proportion of foreign-born people among the newly notified tuberculosis (TB) patients has been increasing in recent years and potentially poses a new challenge to TB control in Japan. In this report, we analysed the data from the Japan TB surveillance system between 2007 and 2014 to gain an overview of the trends and characteristics of foreign-born TB patients in Japan. We found that the proportion of foreign-born TB patients was especially high among the younger age groups – 44.1% among the 20–29 years age group in 2014. The largest groups of foreign-born patients were from China and the Philippines; however, the number of those from Nepal and Viet Nam was on the rise. Students comprised the second largest professional category group for TB after regular workers, and its proportion increased over the study period. Compared to Japan-born TB patients, foreign-born patients were more likely to be diagnosed through routine medical check-ups. Treatment successes and patients still on treatment were significantly lower among foreign-born patients than their Japan-born counterparts; and transferred-out and unknown outcomes were higher. Our results indicated that distinctive subgroups within the foreign-born population in Japan, especially students and regular workers, might have a higher risk of developing TB. Measures to ensure early diagnosis and treatment adherence should be adapted to such populations. PMID:27508086