WorldWideScience

Sample records for boeing aircraft col

  1. Advanced composite elevator for Boeing 727 aircraft

    Science.gov (United States)

    1979-01-01

    Detail design activities are reported for a program to develop an advanced composites elevator for the Boeing 727 commercial transport. Design activities include discussion of the full scale ground test and flight test activities, the ancillary test programs, sustaining efforts, weight status, and the production status. Prior to flight testing of the advanced composites elevator, ground, flight flutter, and stability and control test plans were reviewed and approved by the FAA. Both the ground test and the flight test were conducted according to the approved plan, and were witnessed by the FAA. Three and one half shipsets have now been fabricated without any significant difficulty being encountered. Two elevator system shipsets were weighed, and results validated the 26% predicted weight reduction. The program is on schedule.

  2. Water Injection Feasibility for Boeing 747 Aircraft

    Science.gov (United States)

    Daggett, David L.

    2005-01-01

    Can water injection be offered at a reasonable cost to large airplane operators to reduce takeoff NO( sub x) emissions? This study suggests it may be possible. This report is a contract deliverable to NASA Glenn Research Center from the prime contractor, The Boeing Commercial Airplane Company of Seattle, WA. This study was supported by a separate contract to the Pratt & Whitney Engine Company of Hartford, CT (contract number NNC04QB58P). Aviation continues to grow and with it, environmental pressures are increasing for airports that service commercial airplanes. The feasibility and performance of an emissions-reducing technology, water injection, was studied for a large commercial airplane (e.g., Boeing 747 with PW4062 engine). The primary use of the water-injection system would be to lower NOx emissions while an important secondary benefit might be to improve engine turbine life. A tradeoff exists between engine fuel efficiency and NOx emissions. As engines improve fuel efficiency, by increasing the overall pressure ratio of the engine s compressor, the resulting increased gas temperature usually results in higher NOx emissions. Low-NO(sub x) combustors have been developed for new airplanes to control the increases in NO(sub x) emissions associated with higher efficiency, higher pressure ratio engines. However, achieving a significant reduction of NO(sub x) emissions at airports has been challenging. Using water injection during takeoff has the potential to cut engine NO(sub x) emissions some 80 percent. This may eliminate operating limitations for airplanes flying into airports with emission constraints. This study suggests an important finding of being able to offer large commercial airplane owners an emission-reduction technology that may also save on operating costs.

  3. Mechanical Systems Characterization of Boeing 747 Aging Systems Test Bed Aircraft

    National Research Council Canada - National Science Library

    2002-01-01

    As part of the Federal Aviation Administration (FAA) Aging Aircraft Program, the FAA purchased a Boeing 747 to be used as a test bed aircraft for investigating aging mechanical and electrical systems...

  4. 78 FR 61388 - TA-W-82,705, the Boeing Company Boeing Commercial Aircraft, (BCA) Including On-Site Leased...

    Science.gov (United States)

    2013-10-03

    ... Commercial Aircraft, (BCA) Including On-Site Leased Workers From Chipton Ross, Inc., CTS Technical Services... Services and Yoh Services Auburn, Washington; TA-W-82,705A, the Boeing Company Boeing Commercial Aircraft, (BCA) Including On-Site Leased Workers From Adecco, USA, Inc., Cascade Engineering, CDI Corporation...

  5. NASA's modified Boeing 747 Shuttle Carrier Aircraft with the Space Shuttle Endeavour on top lifts of

    Science.gov (United States)

    2001-01-01

    NASA's modified Boeing 747 Shuttle Carrier Aircraft with the Space Shuttle Endeavour on top lifts off from Edwards Air Force Base to begin its ferry flight back to the Kennedy Space Center in Florida.

  6. Boeing 767 Proximity Evaluation with F/A-18C and S-3B Aircraft

    National Research Council Canada - National Science Library

    Guidry, M

    2001-01-01

    ... under a Private Finance Initiative. Boeing contracted NAWCAD Patuxent River, Maryland, under a commercial service agreement to determine if an area of acceptable wake turbulence existed in the proximity of a 767 aircraft in order...

  7. Simulation model for the Boeing 720B aircraft-flight control system in continuous flight.

    Science.gov (United States)

    1971-08-01

    A mathematical model of the Boeing 720B aircraft and autopilot has been derived. The model is representative of the 720B aircraft for continuous flight within a flight envelope defined by a Mach number of .4 at 20,000 feet altitude in a cruise config...

  8. Dual-band infrared (DBIR) imaging inspections of Boeing 737 and KC-135 aircraft panels

    Energy Technology Data Exchange (ETDEWEB)

    Del Grande, N.K.; Dolan, K.W.; Durbin, P.F.; Gorvad, M.R.; Shapiro, A.B.

    1993-08-27

    We apply dual-band infrared (DBIR) imaging as a dynamic thermal tomography tool for wide area inspection of a Boeing 737 aircraft, and several Boeing KC-135 aircraft panels. Our analyses are discussed in this report. After flash-heating the aircraft skin, we record synchronized DBIR images every 40 ms, from onset to 8 seconds after the heat flash. We analyze selective DBIR image ratios which enhance surface temperature contrast and remove surface-emissivity clutter (from dirt, dents, tape, markings, ink, sealants, uneven paint, paint stripper, exposed metal and roughness variations). The Boeing 737 and KC-135 aircraft fuselage panels have varying percent thickness losses from corrosion. We established the correlation of percent thickness loss with surface temperature rise (above ambient) for a partially corroded F-18 wing box structure and several aluminum reference panels. Based on this correlation, lap splice temperatures rise 1{degrees}C per 24 {plus_minus} 5 % material loss at 0.4 s after the heat flash. We show tables, charts and temperature maps of typical lap splice material losses for the riveted (and bonded) Boeing 737, and the riveted (but unbonded) Boeing KC-135. We map the fuselage composite thermal inertia, based on the (inverse) slope of the surface temperature versus inverse square root of time. Composite thermal inertia maps characterize shallow skin defects within the lap splice at early times (<0.3 s) and deeper skin defects within the lap splice at late times (>0.4 s). Late time composite thermal inertia maps depict where corrosion-related thickness losses occur. Lap splice sites on a typical Boeing KC-135 panel with low composite thermal inertia values had high skin-thickness losses from corrosion.

  9. Advanced composite elevator for Boeing 727 aircraft. Volume 1: Technical summary

    Science.gov (United States)

    Chovil, D. V.; Harvey, S. T.; Mccarty, J. E.; Desper, O. E.; Jamison, E. S.; Syder, H.

    1981-01-01

    The design, development, analysis, and testing activities and results that were required to produce five and one-half shipsets of advanced composite elevators for Boeing 727 aircraft are summarized. During the preliminary design period, alternative concepts were developed. After selection of the best design, detail design and basic configuration improvements were evaluated. Five and one-half shipsets were manufactured. All program goals (except competitive cost demonstration) were accomplished when our design met or exceeded all requirements, criteria, and objectives.

  10. One of NASA's Two Modified Boeing 747 Shuttle Carrier (SCA) Aircraft in Flight over NASA Dryden Flig

    Science.gov (United States)

    1999-01-01

    One of NASA's Boeing 747 Shuttle Carrier Aircraft flies over the Dryden Flight Research Center main building at Edwards Air Force Base, Edwards, California, in May 1999. NASA uses two modified Boeing 747 jetliners, originally manufactured for commercial use, as Space Shuttle Carrier Aircraft (SCA). One is a 747-100 model, while the other is designated a 747-100SR (short range). The two aircraft are identical in appearance and in their performance as Shuttle Carrier Aircraft. The 747 series of aircraft are four-engine intercontinental-range swept-wing 'jumbo jets' that entered commercial service in 1969. The SCAs are used to ferry space shuttle orbiters from landing sites back to the launch complex at the Kennedy Space Center, and also to and from other locations too distant for the orbiters to be delivered by ground transportation. The orbiters are placed atop the SCAs by Mate-Demate Devices, large gantry-like structures which hoist the orbiters off the ground for post-flight servicing, and then mate them with the SCAs for ferry flights. Features which distinguish the two SCAs from standard 747 jetliners are: o Three struts, with associated interior structural strengthening, protruding from the top of the fuselage (two aft, one forward) on which the orbiter is attached o Two additional vertical stabilizers, one on each end of the standard horizontal stabilizer, to enhance directional stability o Removal of all interior furnishings and equipment aft of the forward No. 1 doors o Instrumentation used by SCA flight crews and engineers to monitor orbiter electrical loads during the ferry flights and also during pre- and post-ferry flight operations. The two SCAs are under the operational control of NASA's Johnson Space Center, Houston, Tex. NASA 905 NASA 905 was the first SCA. It was obtained from American Airlines in 1974. Shortly after it was accepted by NASA it was flown in a series of wake vortex research flights at the Dryden Flight Research Center in a study to

  11. Full-scale testing, production and cost analysis data for the advanced composite stabilizer for Boeing 737 aircraft. Volume 1: Technical summary

    Science.gov (United States)

    Aniversario, R. B.; Harvey, S. T.; Mccarty, J. E.; Parsons, J. T.; Peterson, D. C.; Pritchett, L. D.; Wilson, D. R.; Wogulis, E. R.

    1983-01-01

    The full scale ground test, ground vibration test, and flight tests conducted to demonstrate a composite structure stabilizer for the Boeing 737 aircraft and obtain FAA certification are described. Detail tools, assembly tools, and overall production are discussed. Cost analyses aspects covered include production costs, composite material usage factors, and cost comparisons.

  12. Barotrauma in Boeing 737 cabin crew.

    Science.gov (United States)

    Kortschot, H W; Oosterveld, W J

    1993-01-01

    Several aircrew members of a Boeing 737 aircraft were referred to our department because they suffered from a barotrauma. The fast rate of pressure change during the descent of a Boeing 737 aircraft, as compared to the Boeing 747, DC-10 and Airbus 310 aircrafts, is most likely the cause of the development of the barotraumata.

  13. On display during a technical exposition at Dryden are NASA's B-52 launch aircraft, Boeing's X-37, B

    Science.gov (United States)

    2000-01-01

    Aerospace industry representatives view actual and mock-up versions of 'X-Planes' intended to enhance access to space during a technical exposition on June 22, 2000 at Dryden Flight Research Center, Edwards, California. From left to right: NASA's B-52 launch aircraft, in service with NASA since 1959; a neutral-buoyancy model of the Boeing's X-37; the Boeing X-40A behind the MicroCraft X-43 mock-up; Orbital Science's X-34 and the modified Lockheed L-1011 airliner that was to launch the X-34. These X-vehicles are part of NASA's Access to Space plan intended to bring new technologies to bear in an effort to dramatically lower the cost of putting payloads in space, and near-space environments. The June 22, 2000 NASA Reusable Launch Vehicle (RLV) Technology Exposition included presentations on the history, present, and future of NASA's RLV program. Special Sessions for industry representatives highlighted the X-37 project and its related technologies. The X-37 project is managed by NASA's Marshall Space Flight Center, Huntsville, Alabama.

  14. Pilot Comments From the Boeing High Speed Research Aircraft, Cycle 3, Simulation Study of the Effects of Aeroservoelasticity (LaRC.3)

    Science.gov (United States)

    Bailey, Melvin L. (Editor)

    2000-01-01

    This is a compilation of pilot comments from the Boeing High Speed Research Aircraft, Cycle 3, simulation study (LaRC.3) of the effects of aeroservoelasticity, conducted from October to December 1997 at NASA Langley Research Center. This simulation study was conducted using the Visual Motion Simulator. The comments are from direct tape transcriptions and have been edited for spelling only. These comments were made on tape following the completion of each flight card, immediately after the pilot was satisfied with his practice and data recording runs. Six pilots were used in the evaluation and they are identified as pilots A through F.

  15. 78 FR 68985 - Special Conditions: Boeing Model 777-200, -300, and -300ER Series Airplanes; Aircraft Electronic...

    Science.gov (United States)

    2013-11-18

    ... computer network system, and a network extension device. The network extension device will improve domain... Series Airplanes; Aircraft Electronic System Security Protection From Unauthorized Internal Access AGENCY... and connectivity of the passenger service computer network systems to the airplane critical systems...

  16. The Aircraft Industry

    National Research Council Canada - National Science Library

    Fitzgerald, Tim; Baiche, Noureddine; Brewer, Mike; Collins, Al; Knapp, Kathy; Kott, Marilyn; McGill, Duncan; Mensah, Dunstan; Neighbors, Mark; Reardon, Dee

    2005-01-01

    .... As the airline companies prepare to buy new Boeing and Airbus passenger jets, they remain under intense pressure to cut costs in order to remain profitable, forcing aircraft and engine manufacturers...

  17. 77 FR 52201 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-08-29

    ...) software in the airplane information management system (AIMS) hardware. We are issuing this AD to prevent T... Joint Aircraft System Component (JASC)/Air Transport Association (ATA) of America Code 78, Exhaust. (e... information management system hardware, in accordance with the Accomplishment Instructions of Boeing Special...

  18. Nuclear containment structure subjected to commercial and fighter aircraft crash

    Energy Technology Data Exchange (ETDEWEB)

    Sadique, M.R., E-mail: rehan.sadique@gmail.com; Iqbal, M.A., E-mail: iqbalfce@iitr.ernet.in; Bhargava, P., E-mail: bhpdpfce@iitr.ernet.in

    2013-07-15

    Highlights: • Nuclear containment response has been studied against aircraft crash. • Concrete damaged plasticity and Johnson–Cook elasto-viscoplastic models were employed. • Boeing 747-400 and Boeing 767-400 aircrafts caused global failure of containment. • Airbus A320 and Boeing 707-320 aircrafts caused local damage. • Tension damage of concrete was found more prominent compared to compression damage. -- Abstract: The response of a boiling water reactor (BWR) nuclear containment vessel has been studied against commercial and fighter aircraft crash using a nonlinear finite element code ABAQUS. The aircrafts employed were Boeing 747-400, Boeing 767-400, Airbus A-320, Boeing 707-320 and Phantom F4. The containment was modeled as a three-dimensional deformable reinforced concrete structure while the loading of aircraft was assigned using the respective reaction–time curve. The location of strike was considered near the junction of dome and cylinder, and the angle of incidence, normal to the containment surface. The material behavior of the concrete was incorporated using the damaged plasticity model while that of the reinforcement, the Johnson–Cook elasto-viscoplastic model. The containment could not sustain the impact of Boeing 747-400 and Boeing 767-400 aircrafts and suffered rupture of concrete around the impact region leading to global failure. On the other hand, the maximum local deformation at the point of impact was found to be 0.998 m, 0.099 m, 0.092 m, 0.089 m, and 0.074 m against Boeing 747-400, Phantom F4, Boeing 767, Boeing 707-320 and Airbus A-320 aircrafts respectively. The results of the present study were compared with those of the previous analytical and numerical investigations with respect to the maximum deformation and overall behavior of the containment.

  19. Nuclear containment structure subjected to commercial and fighter aircraft crash

    International Nuclear Information System (INIS)

    Sadique, M.R.; Iqbal, M.A.; Bhargava, P.

    2013-01-01

    Highlights: • Nuclear containment response has been studied against aircraft crash. • Concrete damaged plasticity and Johnson–Cook elasto-viscoplastic models were employed. • Boeing 747-400 and Boeing 767-400 aircrafts caused global failure of containment. • Airbus A320 and Boeing 707-320 aircrafts caused local damage. • Tension damage of concrete was found more prominent compared to compression damage. -- Abstract: The response of a boiling water reactor (BWR) nuclear containment vessel has been studied against commercial and fighter aircraft crash using a nonlinear finite element code ABAQUS. The aircrafts employed were Boeing 747-400, Boeing 767-400, Airbus A-320, Boeing 707-320 and Phantom F4. The containment was modeled as a three-dimensional deformable reinforced concrete structure while the loading of aircraft was assigned using the respective reaction–time curve. The location of strike was considered near the junction of dome and cylinder, and the angle of incidence, normal to the containment surface. The material behavior of the concrete was incorporated using the damaged plasticity model while that of the reinforcement, the Johnson–Cook elasto-viscoplastic model. The containment could not sustain the impact of Boeing 747-400 and Boeing 767-400 aircrafts and suffered rupture of concrete around the impact region leading to global failure. On the other hand, the maximum local deformation at the point of impact was found to be 0.998 m, 0.099 m, 0.092 m, 0.089 m, and 0.074 m against Boeing 747-400, Phantom F4, Boeing 767, Boeing 707-320 and Airbus A-320 aircrafts respectively. The results of the present study were compared with those of the previous analytical and numerical investigations with respect to the maximum deformation and overall behavior of the containment

  20. NASA's Boeing 747 SCA with the Space Shuttle Endeavour on top climbs out after takeoff from Edwards

    Science.gov (United States)

    2001-01-01

    NASA's modified Boeing 747 Shuttle Carrier Aircraft with the Space Shuttle Endeavour on top climbs out after takeoff from Edwards Air Force Base on the first leg of its ferry flight back to the Kennedy Space Center in Florida.

  1. Will Boeing Change Health Care?

    Science.gov (United States)

    Stempniak, Marty

    2015-12-01

    Big employers like Boeing and Intel are directly contracting with hospitals in an effort to control health care prices. Some hospital CEOs see direct contracting as the future, while others wonder how they can participate.

  2. Data Mining of NASA Boeing 737 Flight Data: Frequency Analysis of In-Flight Recorded Data

    Science.gov (United States)

    Butterfield, Ansel J.

    2001-01-01

    Data recorded during flights of the NASA Trailblazer Boeing 737 have been analyzed to ascertain the presence of aircraft structural responses from various excitations such as the engine, aerodynamic effects, wind gusts, and control system operations. The NASA Trailblazer Boeing 737 was chosen as a focus of the study because of a large quantity of its flight data records. The goal of this study was to determine if any aircraft structural characteristics could be identified from flight data collected for measuring non-structural phenomena. A number of such data were examined for spatial and frequency correlation as a means of discovering hidden knowledge of the dynamic behavior of the aircraft. Data recorded from on-board dynamic sensors over a range of flight conditions showed consistently appearing frequencies. Those frequencies were attributed to aircraft structural vibrations.

  3. The DoD C-17 Versus the Boeing 777. A Comparison of Acquisition and Development

    Science.gov (United States)

    1999-10-01

    Standard Encyclopedia (New York: Unicorn Publishers, 1955), 102-103. 9. The World Book Encyclopedia (Kansas City, MO: Field Enterprises Educational...were some startup difficulties associated with innovative design...on the 777; the company’s goal was to deliver a fault-free aircraft on time. Startup problems with CATIA threatened Boeing’s delivery schedule

  4. Mutation analysis of COL4A3 and COL4A4 genes in a Chinese ...

    Indian Academy of Sciences (India)

    2016-10-24

    Oct 24, 2016 ... Autosomal-Dominant Alport Syndrome Family. LIWEI GUO1, DUAN LI2, ... COL4A3/COL4A4 locus in a large family from Northern Ireland and 3 years later there came the first report of a COL4A3 ... collagen, whose substitution mutation can interrupt the characteristic triple Gly-X-Y repeats in collagenous ...

  5. Recent progress in V/STOL aircraft technology

    Science.gov (United States)

    Roberts, L.; Deckert, W.; Hickey, D.

    1981-01-01

    Recent results from wind-tunnel and flight-tests investigations for V/STOL aircraft were reviewed. Primary emphasis is given to technical results relating to three types of subsonic aircraft: a quiet STOL aircraft; a tilt rotor aircraft, and a turbofan V/STOL aircraft. Comparison and correlation between theoretical and experimental results, and between wind-tunnel and flight-test results, is made. The quiet STOL aircraft technology results are primarily those derived from the NASA/Boeing Quiet Short Haul Aircraft (QSRA) program. The tilt rotor aircraft technology results are those obtained from the NASA/Army/Navy/Bell (XV-15-TRRA) aircraft flight investigations. The turbofan V/STOL aircraft technology results are from static ground facility and wind-tunnel investigations of a NASA/Navy/Grumman full-scale lift/cruise fan aircraft model, which features two tilting nacelles with TF-34 engines.

  6. Aircraft Age-Related Degradation Study on Single- and Three-Phase Circuit Breakers

    National Research Council Canada - National Science Library

    Peterson, Ronnie

    2002-01-01

    This report provides technical data and brief observations generated for a controlled series of tests on circuit breakers removed from an aging Boeing 727-232 and a McDonnell Douglas DC-10 aircraft...

  7. Boeing Aerospace Co., Seattle, WA

    International Nuclear Information System (INIS)

    Adamski, J.L.; Gallagher, W.J.; Kennedy, R.C.; Shoffstall, D.R.; Tyson, E.L.; Yeremian, A.D.

    1985-01-01

    A two stage subharmonic injector has been installed and tested on the Boeing S band linac. The injector is designed as a prototype front end for a high voltage linac for free electron laser research. This accelerator will require long macropulse trains of widely spaced high current micropulses. Single micropulse output beams of 1-2 nC, 10 ps width, 1% full width energy spread and normalized emittance of epsilon/sub n/ = βγπrphi = 0.01 cm-rad have been measured. The data are in good agreement with model predictions

  8. Innovations in Aircraft Design

    Science.gov (United States)

    1997-01-01

    The Boeing 777 carries with it basic and applied research, technology, and aerodynamic knowledge honed at several NASA field centers. Several Langley Research Center innovations instrumental to the development of the aircraft include knowledge of how to reduce engine and other noise for passengers and terminal residents, increased use of lightweight aerospace composite structures for increased fuel efficiency and range, and wind tunnel tests confirming the structural integrity of 777 wing-airframe integration. Test results from Marshall Space Flight Center aimed at improving the performance of the Space Shuttle engines led to improvements in the airplane's new, more efficient jet engines. Finally, fostered by Ames Research Center, the Boeing 777 blankets that protect areas of the plane from high temperatures and fire have a lineage to Advanced Flexible Reusable Surface Insulation used on certain areas of the Space Shuttle. According to Boeing Company estimates, the 777 has captured three-quarters of new orders for airplanes in its class since the program was launched.

  9. 78 FR 25662 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-05-02

    ...-0361; Directorate Identifier 2013-NM-026-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for all The Boeing Company Model 727... Federal holidays. For Boeing service information identified in this proposed AD, contact Boeing Commercial...

  10. 77 FR 731 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-01-06

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT..., 2012. ADDRESSES: For Boeing service information identified in this AD, contact Boeing Commercial...; telephone (206) 544-5000, extension 1; fax (206) 766-5680; email [email protected]boeing.com ; Internet https://www...

  11. Lidar investigation of wake vortices generated by a landing aircraft

    Science.gov (United States)

    Smalikho, Igor N.; Banakh, Viktor A.; Falits, Andrey V.

    2017-11-01

    The results of measurements of parameters of aircraft wake vortices by a Stream Line coherent Doppler lidar during the three-day experiment on the airfield of Tolmachevo Airport are presented. We have analyzed spatial dynamics and evolution of the wake vortices generated by aircrafts of various types: from the Airbus A319 passenger aircraft to the heavy Boeing B747-8 cargo aircraft entering the landing at Tolmachevo Airport. It is shown that the Stream Line lidar may well be used to obtain reliable information about the presence and intensity of aircraft wake vortices in the vicinity of the runway.

  12. Mutation analysis of COL4A3 and COL4A4 genes in a Chinese ...

    Indian Academy of Sciences (India)

    Autosomal dominant Alport syndrome (ADAS) accounts for 5% of all cases of Alport syndrome (AS), a primary basement membrane disorder arising from mutations in genes encoding the type IV collagen protein family.Mutationsin COL4A3 and COL4A4 genes were reported to be associated with ADAS. In this study, clinical ...

  13. Mutation analysis of COL4A3 and COL4A4 genes in a Chinese

    Indian Academy of Sciences (India)

    Autosomal dominant Alport syndrome (ADAS) accounts for 5% of all cases of Alport syndrome (AS), a primary basement membrane disorder arising from mutations in genes encoding the type IV collagen protein family.Mutationsin COL4A3 and COL4A4 genes were reported to be associated with ADAS. In this study, clinical ...

  14. Mutation analysis of COL4A3 and COL4A4 genes in a Chinese ...

    Indian Academy of Sciences (India)

    2016-10-24

    ,. People's Republic of China ... mutations in COL4A3 and COL4A4 genes which encode type IV collagen α3 and α4 chainsrespectively can .... hematuria and evidence for activation of the unfolded protein response. Focal and ...

  15. Advanced composite elevator for Boeing 727 aircraft, volume 2

    Science.gov (United States)

    Chovil, D. V.; Grant, W. D.; Jamison, E. S.; Syder, H.; Desper, O. E.; Harvey, S. T.; Mccarty, J. E.

    1980-01-01

    Preliminary design activity consisted of developing and analyzing alternate design concepts and selecting the optimum elevator configuration. This included trade studies in which durability, inspectability, producibility, repairability, and customer acceptance were evaluated. Preliminary development efforts consisted of evaluating and selecting material, identifying ancillary structural development test requirements, and defining full scale ground and flight test requirements necessary to obtain Federal Aviation Administration (FAA) certification. After selection of the optimum elevator configuration, detail design was begun and included basic configuration design improvements resulting from manufacturing verification hardware, the ancillary test program, weight analysis, and structural analysis. Detail and assembly tools were designed and fabricated to support a full-scope production program, rather than a limited run. The producibility development programs were used to verify tooling approaches, fabrication processes, and inspection methods for the production mode. Quality parts were readily fabricated and assembled with a minimum rejection rate, using prior inspection methods.

  16. Dynamic thermal tomography for nondestructive inspection of aging aircraft

    Energy Technology Data Exchange (ETDEWEB)

    Del Grande, N.K.; Dolan, K.W.; Durbin, P.F.; Gorvad, M.R.; Shapiro, A.B.

    1993-11-01

    The authors apply dual-band infrared (DBIR) imaging as a dynamic thermal tomography tool for wide area inspection of a Boeing 737 aircraft and several Boeing KC-135 aircraft panels. The analyses are discussed in this report. After flash-heating the aircraft skin, they record synchronized DBIR images every 40 ms, from onset to 8 seconds after the heat flash. They analyze selective DBIR image ratios which enhance surface temperature contrast and remove surface-emissivity clutter. The Boeing 737 and KC-135 aircraft fuselage panels have varying percent thickness losses from corrosion. They established the correlation of percent thickness loss with surface temperature rise (above ambient) for a partially corroded F-18 wing box structure and several aluminum plates which had 6 to 60% thickness losses at milled flat-bottom hole sites. Based on this correlation, lap splice temperatures rise 1C per 24 {plus_minus} 5% material loss at 0.4 s after the heat flash. They tabulate and map corrosion-related percent thickness loss effects for the riveted Boeing 737, and the riveted Boeing KKC-135. They map the fuselage composite thermal inertia, based on the (inverse) slope of the surface temperature versus inverse square root of time. Composite thermal inertia maps characterized shallow skin defects within the lap splice at early times (< 0.3 s) and deeper skin defects within the lap splice at late times (> 0.4 s). Late time composite thermal inertia maps depict where corrosion-related thickness losses occur (e.g., on the inside of the Boeing 737 lap splice, beneath the galley and the latrine). Lap splice sites on a typical Boeing KC-135 panel with low composite thermal inertia values had high skin-thickness losses from corrosion.

  17. Engineering--A Career for 330 Women at Boeing

    Science.gov (United States)

    Minor, Barbara

    1974-01-01

    Describes the efforts of the Boeing Company to encourage and hire women for engineering jobs. Much of the article is devoted to women employed by Boeing in engineering jobs and their comments about engineering as a career for women. (BR)

  18. 76 FR 77371 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2011-12-13

    ... checklist as published in the Boeing Quick Reference Handbook. If on the ground, check the Dispatch... 767-23-0167, dated February 28, 2002, approved for IBR January 17, 2012. (ix) Boeing Service Bulletin...

  19. Innovation ou Financiarisation ? : L’Évolution du Business Model basé sur l’Intégration de Systèmes chez Airbus et Boeing.

    OpenAIRE

    Sakinç, Mustafa Erdem

    2016-01-01

    This dissertation analyzes the dynamics of long-term success in commercial aircraft manufacturing in the US and Europe performed through a historical-comparative methodology employed for firm level analysis. The firm-level case studies are Airbus and Boeing, the two biggest firms in the commercial aircraft manufacturing industry. Through an analytical framework concentrated on business/productive models of corporate activity, the study identifies the social conditions that influence the compe...

  20. Technology Approach: DoD Versus Boeing (A Comparative Study)

    Science.gov (United States)

    2016-01-01

    BOEING (A Comparative Study) A. Lee Battershell This is an analysis of different approaches in the use of technology by Boeing and DoD to determine how...they may have affected development time for the C-17 and the Boeing 777. Boeing’s focus on cost, schedule, performance, and market competition is...military cargo plane, Boeing 777 passenger plane, Air Force tactical plane, strategic airlift capability, management structure 29Defense ARJ, January

  1. 77 FR 37831 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-06-25

    ... Revise Repetitive Interval CAL, Qantas Airways Ltd (Qantas), and Boeing asked that we revise the... discrepancies. Qantas and Boeing asked that the repetitive interval be changed to 7,500 flight hours or 36 months, whichever occurs first. Qantas and Boeing stated that, for low-utilization airplanes, it would...

  2. 77 FR 21426 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-04-10

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for all The Boeing... information identified in this AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management...

  3. 78 FR 21576 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-04-11

    ...-0300; Directorate Identifier 2011-NM-163-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 757.... For service information identified in this proposed AD, contact Boeing Commercial Airplanes, Attention...

  4. 78 FR 13463 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-02-28

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... published in the Federal Register. That AD applies to certain The Boeing Company Model 757 airplanes. That... repetitive inspections for that windshield. For certain The Boeing Company Model 757 airplanes, AD 2012-25-03...

  5. 78 FR 46538 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-08-01

    ...-0666; Directorate Identifier 2013-NM-060-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for all The Boeing Company Model 727... proposed AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707, MC...

  6. 78 FR 43839 - Airworthiness Directives; the Boeing Company

    Science.gov (United States)

    2013-07-22

    ...-0625; Directorate Identifier 2013-NM-013-AD] RIN 2120-AA64 Airworthiness Directives; the Boeing Company...: We propose to supersede an existing airworthiness directive (AD) that applies to certain The Boeing... AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P. O. Box 3707, MC 2H...

  7. 78 FR 49217 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2013-08-13

    ...-1069; Directorate Identifier 2012-NM-044-AD] RIN 2120-AA64 Airworthiness Directives; the Boeing Company... directive (AD), for all The Boeing Company Model 727 airplanes, which proposed to supersede an existing AD... information identified in this AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management...

  8. 78 FR 21569 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-04-11

    ...-0299; Directorate Identifier 2012-NM-072-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for all The Boeing Company Model 727... proposed AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707, MC...

  9. 77 FR 49708 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-08-17

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for all The Boeing.... ADDRESSES: For service information identified in this AD, contact Boeing Commercial Airplanes, Attention...

  10. 78 FR 27010 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-05-09

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... certain The Boeing Company Model 737-100, -200, -200C, - 300, -400, and -500 series airplanes. Those ADs..., December 18, 2000). ADDRESSES: For service information identified in this AD, contact Boeing Commercial...

  11. 78 FR 26286 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-05-06

    ...-0425; Directorate Identifier 2011-NM-273-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... directive (AD) for all The Boeing Company Model 717-200 airplanes. That NPRM proposed requiring repetitive... identified in this proposed AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management...

  12. 78 FR 3363 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2013-01-16

    ...-1318; Directorate Identifier 2012-NM-104-AD] RIN 2120-AA64 Airworthiness Directives; the Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 747... identified in this proposed AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P...

  13. 78 FR 56182 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-09-12

    ...-0859; Directorate Identifier 2012-NM-090-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... to rescind airworthiness directive (AD) 2008-06-03, which applies to certain The Boeing Company Model... ``Different Unsafe Condition'' FedEx, American Airlines, and Boeing requested clarification of the different...

  14. 78 FR 52836 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-08-27

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for all The Boeing..., contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707, MC 2H-65...

  15. 78 FR 27020 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-05-09

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are revising an existing airworthiness directive (AD) for all The Boeing... identified in this AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box...

  16. 78 FR 3365 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-01-16

    ...-1317; Directorate Identifier 2011-NM-194-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Airplanes... holidays. For service information identified in this proposed AD, contact Boeing Commercial Airplanes...

  17. 77 FR 58325 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-09-20

    ...-0987; Directorate Identifier 2012-NM-130-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 737... Friday, except Federal holidays. For service information identified in this proposed AD, contact Boeing...

  18. 78 FR 6202 - Airworthiness Directives; the Boeing Company

    Science.gov (United States)

    2013-01-30

    ... Airworthiness Directives; the Boeing Company AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for certain The Boeing Company Model...). ADDRESSES: For service information identified in this AD, contact Boeing Commercial Airplanes, Attention...

  19. 78 FR 78701 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-12-27

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for certain The Boeing..., contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707, MC 2H-65...

  20. 78 FR 27315 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-05-10

    ...-0369; Directorate Identifier 2012-NM-128-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for all The Boeing Company Model 757... proposed AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707, MC...

  1. 77 FR 34876 - Airworthiness Directives; The Boeing Company

    Science.gov (United States)

    2012-06-12

    ...-0595; Directorate Identifier 2012-NM-055-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 777... holidays. For service information identified in this proposed AD, contact Boeing [[Page 34877

  2. 77 FR 57536 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-09-18

    ...-0936; Directorate Identifier 2011-NM-269-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 737... Friday, except Federal holidays. For service information identified in this proposed AD, contact Boeing...

  3. 78 FR 57542 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-09-19

    ...-0789; Directorate Identifier 2013-NM-127-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... Boeing Company Model 777-200 and -300 series airplanes. AD 2012-12-08 requires an inspection for the part... proposed AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707, MC...

  4. 77 FR 5996 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-02-07

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for certain The Boeing... control system (ECS) wrapped with Boeing Material Specification (BMS) 8-39 or Aeronautical Materials...

  5. 78 FR 73739 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-12-09

    ...-0981; Directorate Identifier 2013-NM-032-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... all The Boeing Company Model MD-90- 30 airplanes. AD 97-11-07 and AD 99-18-23 currently require... holidays. For service information identified in this proposed AD, contact Boeing Commercial Airplanes...

  6. 77 FR 25647 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-05-01

    ...-0424; Directorate Identifier 2011-NM-004-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for all The Boeing Company Model 777... Friday, except Federal holidays. For service information identified in this proposed AD, contact Boeing...

  7. 76 FR 77937 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2011-12-15

    ...-1320; Directorate Identifier 2011-NM-208-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for all The Boeing Company Model 777..., contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707, MC 2H-65...

  8. 78 FR 27310 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2013-05-10

    ...-0368; Directorate Identifier 2012-NM-058-AD] RIN 2120-AA64 Airworthiness Directives; the Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 777... information identified in this proposed AD, contact Boeing Commercial Airplanes, Attention: Data & Services...

  9. 78 FR 52838 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-08-27

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for certain The Boeing... October 1, 2013. ADDRESSES: For service information identified in this AD, contact Boeing Commercial...

  10. 78 FR 55662 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2013-09-11

    ...-0706; Directorate Identifier 2013-NM-067-AD] RIN 2120-AA64 Airworthiness Directives; the Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain the Boeing Company Model DC-9... Federal holidays. For service information identified in this AD, contact Boeing Commercial Airplanes...

  11. 78 FR 73457 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2013-12-06

    ...-1023; Directorate Identifier 2013-NM-042-AD] RIN 2120-AA64 Airworthiness Directives; the Boeing Company... Boeing Company Model 747-100, 747-200B, 747-200F series airplanes. AD 84-19-01 requires repetitive... Friday, except Federal holidays. For service information identified in this proposed AD, contact Boeing...

  12. 77 FR 24835 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-04-26

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for certain The Boeing.... ADDRESSES: For service information identified in this AD, contact Boeing Commercial Airplanes, Attention...

  13. 77 FR 48423 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-08-14

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for certain The Boeing... identified in this AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box...

  14. 78 FR 52875 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2013-08-27

    ...-0701; Directorate Identifier 2013-NM-073-AD] RIN 2120-AA64 Airworthiness Directives; the Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for all the Boeing Company Model 727.... For service information identified in this proposed AD, contact Boeing Commercial Airplanes, Attention...

  15. 77 FR 58334 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-09-20

    ...-0985; Directorate Identifier 2011-NM-250-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 737... Friday, except Federal holidays. For service information identified in this proposed AD, contact Boeing...

  16. 77 FR 47267 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-08-08

    ... Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final...). ADDRESSES: For service information identified in this AD, contact Boeing Commercial Airplanes, Attention...). The SNPRM applied to all Boeing Model 747-100B SUD, 747-300, 747-400, and 747-400D series airplanes...

  17. 77 FR 63714 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-10-17

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for certain The Boeing..., contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707, MC 2H-65...

  18. 77 FR 21422 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-04-10

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... Boeing Company Model 747-100, 747-100B, 747-100B SUD, 747- 200B, 747-200C, 747-200F, 747-300, 747-400..., September 21, 2007). ADDRESSES: For service information identified in this AD, contact Boeing Commercial...

  19. 78 FR 26720 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-05-08

    ...-0366; Directorate Identifier 2011-NM-024-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... Boeing Company Model 747-100, 747- 100B, 747-100B SUD, 747-200B, 747-200C, 747-300, 747-400, 747-400D... identified in this proposed AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P...

  20. 77 FR 12170 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-02-29

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... the AD as of April 4, 2012. ADDRESSES: For service information identified in this AD, contact Boeing... 98124-2207; telephone 206- 544-5000, extension 1; fax 206-766-5680; email [email protected]boeing.com...

  1. 78 FR 15332 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-03-11

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... directive (AD) that applies to all The Boeing Company Model 737-300, -400, and - 500 series airplanes. The... Friday, except Federal holidays. For service information identified in this proposed AD, contact Boeing...

  2. 78 FR 28128 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2013-05-14

    ... Airworthiness Directives; the Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for all The Boeing... information identified in this AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management...

  3. 77 FR 71723 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-12-04

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... directive (AD) that applies to certain The Boeing Company Model 737-200, -200C, - 300, and -400 series... proposed AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707, MC...

  4. 77 FR 46343 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-08-03

    ...-0804; Directorate Identifier 2012-NM-094-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... certain The Boeing Company Model 747-100, 747-100B, 747-100B SUD, 747-200B, 747-200C, 747-200F, 747-300... Friday, except Federal holidays. For service information identified in this proposed AD, contact Boeing...

  5. 77 FR 40307 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-07-09

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... revising an earlier proposed airworthiness directive (AD) for certain The Boeing Company Model 747-400... proposed AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P. O. Box 3707, MC...

  6. 78 FR 24037 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-04-24

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for all The Boeing... AD until Boeing has released service information. (Specific modifications and solutions were not...

  7. 78 FR 21571 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-04-11

    ...-0304; Directorate Identifier 2013-NM-005-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 747... identified in this proposed AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P...

  8. 78 FR 57049 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2013-09-17

    ... Airworthiness Directives; the Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for certain The Boeing..., 2013. ADDRESSES: For service information identified in this AD, contact Boeing Commercial Airplanes...

  9. 78 FR 53078 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-08-28

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... (AD) for certain The Boeing Company Model 747-200B, -200C, -200F, -300, and 747SR series airplanes... holidays. For service information identified in this proposed AD, contact Boeing Commercial Airplanes...

  10. 77 FR 59728 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-10-01

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... Boeing Company Model DC-10-10, DC-10-10F, DC-10-15, DC- 10-30, DC-10-30F (KC-10A and KDC-10), DC-10-40... this AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, 3855 Lakewood...

  11. 77 FR 57541 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-09-18

    ...-0938; Directorate Identifier 2011-NM-271-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 737... proposed AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707, MC...

  12. 77 FR 57539 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-09-18

    ...-0935; Directorate Identifier 2011-NM-256-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 737... information identified in this proposed AD, contact Boeing Commercial Airplanes, Attention: Data & Services...

  13. 77 FR 43547 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-07-25

    ...-0723; Directorate Identifier 2011-NM-137-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 737... Federal holidays. For service information identified in this proposed AD, contact Boeing [[Page 43548...

  14. 78 FR 68693 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-11-15

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for certain The Boeing.... ADDRESSES: For service information identified in this AD, contact Boeing Commercial Airplanes, Attention...

  15. 77 FR 57529 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-09-18

    ...-0937; Directorate Identifier 2011-NM-270-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 737... identified in this proposed AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P...

  16. 77 FR 24831 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-04-26

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for certain The Boeing... directive (AD): 2012-08-17 The Boeing Company: Amendment 39-17034; Docket No. FAA- 2012-0110; Directorate...

  17. 78 FR 24673 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-04-26

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... (AD) for The Boeing Company Model 787-8 airplanes. That AD currently requires modification of the... information identified in this AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management...

  18. 78 FR 31867 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-05-28

    ...-0425; Directorate Identifier 2012-NM-224-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 747... Friday, except Federal holidays. For service information identified in this proposed AD, contact Boeing...

  19. 77 FR 12166 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-02-29

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... identified in this AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box...; email [email protected]boeing.com ; Internet https://www.myboeingfleet.com . You may review copies of the...

  20. 78 FR 73744 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-12-09

    ...-0268; Directorate Identifier 2011-NM-129-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... proposed rulemaking (SNPRM) for all The Boeing Company Model 737-600, -700, - 700C, -800, -900 and -900ER... information identified in this proposed AD, contact Boeing Commercial Airplanes, Attention: Data & Services...

  1. 77 FR 33619 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-06-07

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... Boeing Company Model 767-200, -300, and -400ER series airplanes. That AD currently requires replacing the... FR 8717, February 26, 2009). ADDRESSES: For service information identified in this AD, contact Boeing...

  2. 78 FR 73460 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2013-12-06

    ...-0978; Directorate Identifier 2013-NM-120-AD] RIN 2120-AA64 Airworthiness Directives; the Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 767... Federal holidays. For service information identified in this proposed AD, contact Boeing Commercial...

  3. 78 FR 11972 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-02-21

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for certain The Boeing... service information identified in this AD, contact Boeing Commercial Airplanes, Attention: Data & Services...

  4. 78 FR 15281 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-03-11

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for all The Boeing... April 15, 2013. ADDRESSES: For service information identified in this AD, contact Boeing Commercial...

  5. 77 FR 24355 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-04-24

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for certain The Boeing... this AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707, MC...

  6. 77 FR 55159 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-09-07

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... revising an earlier proposed airworthiness directive (AD) for certain The Boeing Company Model 737-700... p.m., Monday through Friday, except Federal holidays. For Boeing service information identified in...

  7. 78 FR 46540 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-08-01

    ...-0667; Directorate Identifier 2013-NM-062-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 747... Federal holidays. For service information identified in this proposed AD, contact Boeing Commercial...

  8. 77 FR 51724 - Airworthiness Directives; The Boeing Company

    Science.gov (United States)

    2012-08-27

    ...-0258; Directorate Identifier 2010-NM-191-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... directive (AD) for certain The Boeing Company Model 737-600, -700, -700C, -800, - 900, and -900ER series... information identified in this proposed AD, contact Boeing Commercial Airplanes, Attention: Data & Services...

  9. 78 FR 72836 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-12-04

    ...-0977; Directorate Identifier 2013-NM-190-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for all The Boeing Company Model 717-200... proposed AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, 3855 Lakewood...

  10. 78 FR 49237 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2013-08-13

    ...-0673; Directorate Identifier 2013-NM-057-AD] RIN 2120-AA64 Airworthiness Directives; the Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 707... Federal holidays. For service information identified in this proposed AD, contact Boeing Commercial...

  11. 78 FR 49229 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-08-13

    ...-0690; Directorate Identifier 2013-NM-088-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... Boeing Company Model 737-600, -700, - 700C, and -800 series airplanes. AD 2009-24-07 currently requires... holidays. For service information identified in this proposed AD, contact Boeing Commercial Airplanes...

  12. 77 FR 71731 - Airworthiness Directives; The Boeing Company

    Science.gov (United States)

    2012-12-04

    ...-1221; Directorate Identifier 2012-NM-151-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 777-200.... For service information identified in this proposed AD, contact Boeing Commercial Airplanes, Attention...

  13. 77 FR 61731 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-10-11

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... directive (AD) that applies to all The Boeing Company Model 727 airplanes. The existing AD currently... Friday, except Federal holidays. For service information identified in this proposed AD, contact Boeing...

  14. 78 FR 78703 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-12-27

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for certain The Boeing... service information identified in this AD, contact Boeing Commercial Airplanes, Attention: Data & Services...

  15. 78 FR 27001 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-05-09

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... Boeing Company Model 737-200, -200C, -300, -400, and - 500 series airplanes. That AD currently requires a...: For service information identified in this AD, contact Boeing Commercial Airplanes, Attention: Data...

  16. 77 FR 46340 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-08-03

    ...-0803; Directorate Identifier 2011-NM-214-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to supersede an existing airworthiness directive (AD) that applies to all The Boeing... holidays. For service information identified in this AD, contact Boeing Commercial Airplanes, Attention...

  17. 78 FR 58982 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-09-25

    ...-0796; Directorate Identifier 2013-NM-111-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to supersede airworthiness directive (AD) 2013-07- 07, which applies to all The Boeing... information identified in this AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management...

  18. 78 FR 28764 - Airworthiness Directives; The Boeing Company

    Science.gov (United States)

    2013-05-16

    ...-0421; Directorate Identifier 2013-NM-003-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 737-300... identified in this proposed AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P...

  19. 77 FR 21429 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-04-10

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for certain The Boeing... this AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707, MC...

  20. 78 FR 9 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-01-02

    ... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... Boeing Company Model 737-300, -400, and -500 series airplanes. That AD currently requires repetitive... information identified in this AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management...

  1. 78 FR 40060 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-07-03

    ...-0468; Directorate Identifier 2012-NM-147-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... Boeing Company Model 777-200 and -300 series airplanes equipped with Rolls-Royce engines. The existing AD... identified in this AD, Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707, MC...

  2. 77 FR 58330 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-09-20

    ...-0994; Directorate Identifier 2012-NM-119-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to supersede an existing airworthiness directive (AD) that applies to all The Boeing... replacement of any discrepant elevator tab control mechanism. Since we issued that AD, Boeing has developed a...

  3. 78 FR 40050 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-07-03

    ...-0540; Directorate Identifier 2012-NM-185-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... Boeing Company Model 747-100, 747- 100B, 747-100B SUD, 747-200B, 747-200C, 747-200F, 747-300, 747-400... Federal holidays. For service information identified in this AD, contact Boeing Commercial Airplanes...

  4. 78 FR 46532 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2013-08-01

    ...-0616; Directorate Identifier 2007-NM-353-AD] RIN 2120-AA64 Airworthiness Directives; the Boeing Company... directive (AD) for all The Boeing Company Model 767 airplanes. That NPRM proposed to require repetitive... Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707, MC 2H-65, Seattle, WA...

  5. 78 FR 75512 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-12-12

    ...-1027; Directorate Identifier 2013-NM-121-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 737... Friday, except Federal holidays. For service information identified in this proposed AD, contact Boeing...

  6. 77 FR 63266 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-10-16

    ...-1073; Directorate Identifier 2012-NM-078-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 767... holidays. For service information identified in this proposed AD, contact Boeing Commercial Airplanes...

  7. 77 FR 47329 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-08-08

    ...-0805; Directorate Identifier 2012-NM-117-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... propose to rescind an existing airworthiness directive (AD) that applies to certain The Boeing Company... service information identified in this proposed AD, contact Boeing Commercial Airplanes, Attention: Data...

  8. The Boeing prospective study and beyond.

    Science.gov (United States)

    Volinn, E; Spratt, K F; Magnusson, M; Pope, M H

    2001-07-15

    The Boeing prospective study was reviewed. The Boeing prospective study, comprising two articles, was a large field study that explored why workers would or would not report occupational back pain problems. The most immediate objective was to determine the extent to which conclusions drawn from the Boeing prospective study withstand critical examination. The ultimate purpose of this review was to develop guidelines for field studies of back pain in industry. For more than a century, researchers have noted great variability among individuals in the reporting of back pain, but the explanations posed for this variability have been inconsistent. Because findings gain credibility roughly to the extent that they bear on the world outside the laboratory, field studies in particular hold great potential for clarifying the underlying explanation for individual variability in back pain reporting. The Boeing prospective study was a large and ambitious field study that examined this issue. The Boeing prospective study was examined through the lens of research conducted since it was published. The review used both the methodological and substantive literature. The Boeing prospective study, based on a minority of workers originally solicited to participate in it (33-41%), accounted for 7% of the variation in why workers would or would not report a back pain problem. A number of issues that may have biased its results toward the null are examined. The highlighting of the Boeing prospective study's limitations may be instructive not so much to criticize this one particular study but, rather, to anticipate problems that in general may be encountered in field studies of back pain in industry. Looking beyond the Boeing prospective study, the following guidelines for the conduct of such studies may be proposed: 1) Study designs should be based on explanations from which testable hypotheses may be derived; 2) Subgroups within the more general category of "back pain" should be

  9. Modern trends of aircraft fly-by-wire systems

    Directory of Open Access Journals (Sweden)

    С. С. Юцкевич

    2013-07-01

    Full Text Available Specifics of civil aviation modern transport aircraft fly-by-wire control systems are described. A comparison of the systems-level hardware and software, expressed through modes of guidance, provision of aircraft Airbus A-320, Boeing B-777, Tupolev Tu-214, Sukhoi Superjet SSJ-100 are carried out. The possibility of transition from mechanical control wiring to control through fly-by-wire system in the backup channel is shown.

  10. Retratos de Colón

    Directory of Open Access Journals (Sweden)

    Enrique Uribe White

    1968-02-01

    Full Text Available Hay otro cuadro que prefiero, debido al persistente pensamiento de que puede ser un retrato póstumo de Colón, por alguien que lo conoció. por el año de 1520 Alejo Fernández de Córdoba pintó para la confradía de pilotos, conramaestres y dueños de barcos, en Sevilla un cuadro llamado Nuestra Señora del Buen Aire.

  11. SUPPLY CHAIN FEATURES OF THE AEROSPACE INDUSTRY PARTICULAR CASE AIRBUS AND BOEING

    Directory of Open Access Journals (Sweden)

    Daniela MOCENCO

    2015-10-01

    Full Text Available Aerospace sector is one of the most globalized industries in terms of market structure and production system. Through aircraft development programs aviation industry has introduced new solutions to develop its products. The role of the partners involved in the development programs for the new generation aircraft is becoming increasingly important. Supply chain management has become a key factor for major manufacturers in the industry. The new strategies introduced by the aircraft manufacturers have increased the complexity of the supply process, design and production from the aviation industry. This paper highlights a series of factors regarding the aircraft programs supply chain management. In the first part are described the problems encountered by the manufacturers and airlines during the development of the most recent aircraft launched A350XWB and B787 Dreamliner; the second part focuses on the organizational structure of the supply chain, suppliers role within supply chain and also there are described the effects of the new strategies adopted by Airbus and Boeing in the aircraft development; the last part focuses on the risks and challenges that aviation industry is facing.

  12. Col11a1 Regulates Bone Microarchitecture during Embryonic Development

    Directory of Open Access Journals (Sweden)

    Anthony Hafez

    2015-12-01

    Full Text Available Collagen XI alpha 1 (Col11a1 is an extracellular matrix molecule required for embryonic development with a role in both nucleating the formation of fibrils and regulating the diameter of heterotypic fibrils during collagen fibrillar assembly. Although found in many different tissues throughout the vertebrate body, Col11a1 plays an essential role in endochondral ossification. To further understand the function of Col11a1 in the process of bone formation, we compared skeletal mineralization in wild-type (WT mice and Col11a1-deficient mice using X-ray microtomography (micro-CT and histology. Changes in trabecular bone microstructure were observed and are presented here. Additionally, changes to the periosteal bone collar of developing long bones were observed and resulted in an increase in thickness in the case of Col11a1-deficient mice compared to WT littermates. Vertebral bodies were incompletely formed in the absence of Col11a1. The data demonstrate that Col11a1 depletion results in alteration to newly-formed bone and is consistent with a role for Col11a1 in mineralization. These findings indicate that expression of Col11a1 in the growth plate and perichondrium is essential for trabecular bone and bone collar formation during endochondral ossification. The observed changes to mineralized tissues further define the function of Col11a1.

  13. Capacity assessment of concrete containment vessels subjected to aircraft impact

    International Nuclear Information System (INIS)

    Andonov, Anton; Kostov, Marin; Iliev, Alexander

    2015-01-01

    Highlights: • An approach to assess the containment capacity to aircraft impact via fragility curves is proposed. • Momentum over Area was defined as most suitable reference parameter to describe the aircraft load. • The effect of the impact induced damages on the containment pressure capacity has been studied. • The studied containment shows no reduction of the pressure capacity for the investigated scenarios. • The effectiveness of innovative protective structure against aircraft impact has been evaluated. - Abstract: The paper describes the procedure and the results from the assessment of the vulnerability of a generic pre-stressed containment structure subjected to a large commercial aircraft impact. Impacts of Boeing 737, Boeing 767 and Boeing 747 have been considered. The containment vulnerability is expressed by fragility curves based on the results of a number of nonlinear dynamic analyses. Three reference parameters have been considered as impact intensity measure in the fragility curve definition: peak impact force (PIF), peak impact pressure (PIP) and Momentum over Area (MoA). Conclusions on the most suitable reference parameter as well on the vulnerability of such containment vessels are drawn. The influence of the aircraft impact induced damages on the containment ultimate pressure capacity is also assessed and some preliminary conclusions on this are drawn. The paper also addresses a conceptual design of a protective structure able to decrease the containment vulnerability and provide a preliminary assessment of the applicability of such concept.

  14. Capacity assessment of concrete containment vessels subjected to aircraft impact

    Energy Technology Data Exchange (ETDEWEB)

    Andonov, Anton, E-mail: anton.andonov@mottmac.com; Kostov, Marin; Iliev, Alexander

    2015-12-15

    Highlights: • An approach to assess the containment capacity to aircraft impact via fragility curves is proposed. • Momentum over Area was defined as most suitable reference parameter to describe the aircraft load. • The effect of the impact induced damages on the containment pressure capacity has been studied. • The studied containment shows no reduction of the pressure capacity for the investigated scenarios. • The effectiveness of innovative protective structure against aircraft impact has been evaluated. - Abstract: The paper describes the procedure and the results from the assessment of the vulnerability of a generic pre-stressed containment structure subjected to a large commercial aircraft impact. Impacts of Boeing 737, Boeing 767 and Boeing 747 have been considered. The containment vulnerability is expressed by fragility curves based on the results of a number of nonlinear dynamic analyses. Three reference parameters have been considered as impact intensity measure in the fragility curve definition: peak impact force (PIF), peak impact pressure (PIP) and Momentum over Area (MoA). Conclusions on the most suitable reference parameter as well on the vulnerability of such containment vessels are drawn. The influence of the aircraft impact induced damages on the containment ultimate pressure capacity is also assessed and some preliminary conclusions on this are drawn. The paper also addresses a conceptual design of a protective structure able to decrease the containment vulnerability and provide a preliminary assessment of the applicability of such concept.

  15. Control Reallocation Strategies for Damage Adaptation in Transport Class Aircraft

    Science.gov (United States)

    Gundy-Burlet, Karen; Krishnakumar, K.; Limes, Greg; Bryant, Don

    2003-01-01

    This paper examines the feasibility, potential benefits and implementation issues associated with retrofitting a neural-adaptive flight control system (NFCS) to existing transport aircraft, including both cable/hydraulic and fly-by-wire configurations. NFCS uses a neural network based direct adaptive control approach for applying alternate sources of control authority in the presence of damage or failures in order to achieve desired flight control performance. Neural networks are used to provide consistent handling qualities across flight conditions, adapt to changes in aircraft dynamics and to make the controller easy to apply when implemented on different aircraft. Full-motion piloted simulation studies were performed on two different transport models: the Boeing 747-400 and the Boeing C-17. Subjects included NASA, Air Force and commercial airline pilots. Results demonstrate the potential for improving handing qualities and significantly increased survivability rates under various simulated failure conditions.

  16. Detection of COL III in Parchment by Amino Acid Analysis

    DEFF Research Database (Denmark)

    Vestergaard Poulsen Sommer, Dorte; Larsen, René

    2016-01-01

    Cultural heritage parchments made from the reticular dermis of animals have been subject to studies of deterioration and conservation by amino acid analysis. The reticular dermis contains a varying mixture of collagen I and III (COL I and III). When dealing with the results of the amino acid...... analyses, till now the COL III content has not been taken into account. Based on the available amino acid sequences we present a method for determining the amount of COL III in the reticular dermis of new and historical parchments calculated from the ratio of Ile/Val. We find COL III contents between 7...... and 32 % in new parchments and between 0.2 and 40 % in the historical parchments. This is consistent with results in the literature. The varying content of COL III has a significant influence on the uncertainty of the amino acid analysis. Although we have not found a simple correlation between the COL...

  17. Boeing's High Voltage Solar Tile Test Results

    Science.gov (United States)

    Reed, Brian J.; Harden, David E.; Ferguson, Dale C.; Snyder, David B.

    2002-01-01

    Real concerns of spacecraft charging and experience with solar array augmented electrostatic discharge arcs on spacecraft have minimized the use of high voltages on large solar arrays despite numerous vehicle system mass and efficiency advantages. Boeing's solar tile (patent pending) allows high voltage to be generated at the array without the mass and efficiency losses of electronic conversion. Direct drive electric propulsion and higher power payloads (lower spacecraft weight) will benefit from this design. As future power demand grows, spacecraft designers must use higher voltage to minimize transmission loss and power cable mass for very large area arrays. This paper will describe the design and discuss the successful test of Boeing's 500-Volt Solar Tile in NASA Glenn's Tenney chamber in the Space Plasma Interaction Facility. The work was sponsored by NASA's Space Solar Power Exploratory Research and Technology (SERT) Program and will result in updated high voltage solar array design guidelines being published.

  18. Design and Test of a Blast Shield for Boeing 737 Overhead Compartment

    Directory of Open Access Journals (Sweden)

    Xinglai Dang

    2006-01-01

    Full Text Available This work demonstrates the feasibility of using a composite blast shield for hardening an overhead bin compartment of a commercial aircraft. If a small amount of explosive escapes detection and is brought onboard and stowed in an overhead bin compartment of a passenger aircraft, the current bins provide no protection against a blast inside the compartment. A blast from the overhead bin will certainly damage the fuselage and likely lead to catastrophic inflight structural failure. The feasibility of using an inner blast shield to harden the overhead bin compartment of a Boeing 737 aircraft to protect the fuselage skin in such a threat scenario has been demonstrated using field tests. The blast shield was constructed with composite material based on the unibody concept. The design was carried out using LS-DYNA finite element model simulations. Material panels were first designed to pass the FAA shock holing and fire tests. The finite element model included the full coupling of the overhead bin with the fuselage structure accounting for all the different structural connections. A large number of iterative simulations were carried out to optimize the fiber stacking sequence and shield thickness to minimize weight and achieve the design criterion. Three designs, the basic, thick, and thin shields, were field-tested using a frontal fuselage section of the Boeing 737–100 aircraft. The basic and thick shields protected the integrity of the fuselage skin with no skin crack. This work provides very encouraging results and useful data for optimization implementation of the blast shield design for hardening overhead compartments against the threat of small explosives.

  19. 78 FR 22439 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-04-16

    ... 737-100/-200 SRM 53-30-1, Figures 20, 21, 31, or 32; and Boeing 737-300/-400/-500 SRM 53-10-01, Repair... guidance on repairs may be found in Boeing 737-100/-200 SRM 53-30-1, Figure 20, 21, 31, or 32; or Boeing... 21, 2008), with revised method of compliance language. The inspections specified in paragraph (g) of...

  20. Sonic Boom Minimization Efforts on Boeing HSCT Baseline

    Science.gov (United States)

    Cheung, Samson H.; Fouladi, Kamran; Haglund, George; Tu, Eugene

    1999-01-01

    A team was formed to tackle the sonic boom softening issues of the current Boeing HSCT design. The team consisted of personnel from NASA Ames, NASA Langley, and Boeing company. The work described in this paper was done when the first author was at NASA Ames Research Center. This paper presents the sonic boom softening work on two Boeing High Speed Civil Transport (HSCT) baseline configurations, Reference-H and Boeing-1122. This presentation can be divided into two parts: parametric studies and sonic boom minimization by CFD optimization routines.

  1. AI Research and Application Development at Boeing's Huntsville Laboratories

    OpenAIRE

    Tanner, Steve; Carnes, Ray

    1993-01-01

    This article contains an overview of recent and ongoing projects at Boeing's Huntsville Advanced Computing Group (ACG). In addition, it contains an overview of some of the work being conducted by Boeing's Advanced Civil Space Systems Group. One aspect of ACG's charter is to support the efforts of other groups at Boeing. Thus, AI is not considered a stand-alone field but, instead, is considered an area that can be used to find both long- and short-term solutions for Boeing and its customers. A...

  2. Childhood presentation of COL4A1 mutations

    NARCIS (Netherlands)

    Shah, S.; Ellard, S.; Kneen, R.; Lim, M.; Osborne, N.; Rankin, J.; Stoodley, N.; van der Knaap, M.S.; Whitney, A.; Jardine, P.

    2012-01-01

    Aim To describe the clinical and radiological features of four new families with a childhood presentation of COL4A1 mutation. Method We retrospectively reviewed the clinical presentation. Investigations included radiological findings and COL4A1 mutation analysis of the four cases. Affected family

  3. Childhood presentation of COL4A1 mutations

    NARCIS (Netherlands)

    Shah, Siddharth; Ellard, Sian; Kneen, Rachel; Lim, Ming; Osborne, Nigel; Rankin, Julia; Stoodley, Neil; van der Knaap, Marjo; Whitney, Andrea; Jardine, Philip

    2012-01-01

    To describe the clinical and radiological features of four new families with a childhood presentation of COL4A1 mutation. We retrospectively reviewed the clinical presentation. Investigations included radiological findings and COL4A1 mutation analysis of the four cases. Affected family members were

  4. COL9A2 and COL9A3 mutations in canine autosomal recessive oculoskeletal dysplasia.

    Science.gov (United States)

    Goldstein, Orly; Guyon, Richard; Kukekova, Anna; Kuznetsova, Tatyana N; Pearce-Kelling, Susan E; Johnson, Jennifer; Aguirre, Gustavo D; Acland, Gregory M

    2010-08-01

    Oculoskeletal dysplasia segregates as an autosomal recessive trait in the Labrador retriever and Samoyed canine breeds, in which the causative loci have been termed drd1 and drd2, respectively. Affected dogs exhibit short-limbed dwarfism and severe ocular defects. The disease phenotype resembles human hereditary arthro-ophthalmopathies such as Stickler and Marshall syndromes, although these disorders are usually dominant. Linkage studies mapped drd1 to canine chromosome 24 and drd2 to canine chromosome 15. Positional candidate gene analysis then led to the identification of a 1-base insertional mutation in exon 1 of COL9A3 that cosegregates with drd1 and a 1,267-bp deletion mutation in the 5' end of COL9A2 that cosegregates with drd2. Both mutations affect the COL3 domain of the respective gene. Northern analysis showed that RNA expression of the respective genes was reduced in affected retinas. These models offer potential for studies such as protein-protein interactions between different members of the collagen gene family, regulation and expression of these genes in retina and cartilage, and even opportunities for gene therapy.

  5. 77 FR 10403 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-02-22

    ...-0145; Directorate Identifier 2011-NM-066-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... Boeing Company Model 767 airplanes. The existing AD currently requires revising the Airworthiness... of certain doors and flaps was done based on their fatigue-critical nature. This proposed AD would...

  6. 78 FR 57053 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-09-17

    ... Management Facility, U.S. Department of Transportation, Docket Operations, M-30, West Building Ground Floor..., 2011, instead of only the alternative method of compliance process. UPS asserted that Boeing Alert...) and (h) of this AD at the applicable time specified in the logic diagram in Figure 1 of Boeing Alert...

  7. 78 FR 23685 - Airworthiness Directives; The Boeing Company

    Science.gov (United States)

    2013-04-22

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011-0153; Directorate Identifier 2010-NM-022-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... airworthiness directive (AD) for certain The Boeing Company Model 777-200 and -300 series airplanes. The...

  8. 77 FR 47330 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-08-08

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011-0158; Directorate Identifier 2010-NM-118-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... to supersede an existing airworthiness directive (AD) that applies to certain The Boeing Company...

  9. 78 FR 23690 - Airworthiness Directives; The Boeing Company

    Science.gov (United States)

    2013-04-22

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011-0034; Directorate Identifier 2010-NM-021-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... airworthiness directive (AD) for certain The Boeing Company Model 777-200 series airplanes. The proposed AD...

  10. 78 FR 23691 - Airworthiness Directives; the Boeing Company

    Science.gov (United States)

    2013-04-22

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011-0033; Directorate Identifier 2010-NM-019-AD] RIN 2120-AA64 Airworthiness Directives; the Boeing Company... airworthiness directive (AD) for certain The Boeing Company Model 777-200 series airplanes. The proposed AD...

  11. Mutation analysis of the COL1A1 and COL1A2 genes in Vietnamese patients with osteogenesis imperfecta.

    Science.gov (United States)

    Ho Duy, Binh; Zhytnik, Lidiia; Maasalu, Katre; Kändla, Ivo; Prans, Ele; Reimann, Ene; Märtson, Aare; Kõks, Sulev

    2016-08-12

    The genetics of osteogenesis imperfecta (OI) have not been studied in a Vietnamese population before. We performed mutational analysis of the COL1A1 and COL1A2 genes in 91 unrelated OI patients of Vietnamese origin. We then systematically characterized the mutation profiles of these two genes which are most commonly related to OI. Genomic DNA was extracted from EDTA-preserved blood according to standard high-salt extraction methods. Sequence analysis and pathogenic variant identification was performed with Mutation Surveyor DNA variant analysis software. Prediction of the pathogenicity of mutations was conducted using Alamut Visual software. The presence of variants was checked against Dalgleish's osteogenesis imperfecta mutation database. The sample consisted of 91 unrelated osteogenesis imperfecta patients. We identified 54 patients with COL1A1/2 pathogenic variants; 33 with COL1A1 and 21 with COL1A2. Two patients had multiple pathogenic variants. Seventeen novel COL1A1 and 10 novel COL1A2 variants were identified. The majority of identified COL1A1/2 pathogenic variants occurred in a glycine substitution (36/56, 64.3 %), usually serine (23/36, 63.9 %). We found two pathogenic variants of the COL1A1 gene c.2461G > A (p.Gly821Ser) in four unrelated patients and one, c.2005G > A (p.Ala669Thr), in two unrelated patients. Our data showed a lower number of collagen OI pathogenic variants in Vietnamese patients compared to reported rates for Asian populations. The OI mutational profile of the Vietnamese population is unique and related to the presence of a high number of recessive mutations in non-collagenous OI genes. Further analysis of OI patients negative for collagen mutations, is required.

  12. Development of lightweight, fire-retardant, low smoke, high strength, thermally stable aircraft floor paneling

    Science.gov (United States)

    Anderson, R. A.; Karch, R. T.

    1978-01-01

    Boeing's participation in a NASA funded program (FIREMEN) to develop materials for use as floor panels possessing flammability, smoke and toxicity characteristics superior to current materials is outlined. The objectives of the program are to develop an aircraft floor paneling suitable for high traffic areas, e.g., aisle or galley and to install and certify the panel in a commercial aircraft for service evaluation.

  13. Threats to Aircraft Structural Safety Including a Compendium of Selected Structural Accidents/Incidents

    Science.gov (United States)

    2010-03-01

    Photos Illustrating Rivet Damage on 747SR Rear Pressure Bulkhead C10 C13 Photo of Boeing 747-200 C11 C14 Crack Location under Edge of Repair...Association AIB Accident Investigation Board AIDS Accident/Incident Data System API Armor Piercing Incendiary ASIP Aircraft Structural...transport aircraft be designed to be fail-safe in spite of the fact that some manufacturers have such self imposed design requirements. The lack of such a

  14. Evaluation the COL9A2 gene with high myopia

    Science.gov (United States)

    Zhang, Dingding; Huang, Maomin

    2017-11-01

    This paper investigates the association of the COL9A2 gene between high myopia and normal controls in the Han Chinese population. It shows that the frameshift mutation (D281fs) in the COL9A2 gene is not associated with high myopia in the Han Chinese population, and the two novel variants(c.143G>C and c.884G>A) may contribute to the development of high myopia.

  15. Final Technical Report. Project Boeing SGS

    Energy Technology Data Exchange (ETDEWEB)

    Bell, Thomas E. [The Boeing Company, Seattle, WA (United States)

    2014-12-31

    Boeing and its partner, PJM Interconnection, teamed to bring advanced “defense-grade” technologies for cyber security to the US regional power grid through demonstration in PJM’s energy management environment. Under this cooperative project with the Department of Energy, Boeing and PJM have developed and demonstrated a host of technologies specifically tailored to the needs of PJM and the electric sector as a whole. The team has demonstrated to the energy industry a combination of processes, techniques and technologies that have been successfully implemented in the commercial, defense, and intelligence communities to identify, mitigate and continuously monitor the cyber security of critical systems. Guided by the results of a Cyber Security Risk-Based Assessment completed in Phase I, the Boeing-PJM team has completed multiple iterations through the Phase II Development and Phase III Deployment phases. Multiple cyber security solutions have been completed across a variety of controls including: Application Security, Enhanced Malware Detection, Security Incident and Event Management (SIEM) Optimization, Continuous Vulnerability Monitoring, SCADA Monitoring/Intrusion Detection, Operational Resiliency, Cyber Range simulations and hands on cyber security personnel training. All of the developed and demonstrated solutions are suitable for replication across the electric sector and/or the energy sector as a whole. Benefits identified include; Improved malware and intrusion detection capability on critical SCADA networks including behavioral-based alerts resulting in improved zero-day threat protection; Improved Security Incident and Event Management system resulting in better threat visibility, thus increasing the likelihood of detecting a serious event; Improved malware detection and zero-day threat response capability; Improved ability to systematically evaluate and secure in house and vendor sourced software applications; Improved ability to continuously monitor

  16. Report on Boeing pipeline leak detection system

    International Nuclear Information System (INIS)

    Aichele, W.T.

    1978-08-01

    Testing was performed on both simulated (test) and existing (water) pipelines to evaluate the Boeing leak detection technique. This technique uses a transformer mounted around the pipe to induce a voltage level onto the pipeline. The induced ground potential is measured from a distant ground probe, inserted into the surrounding soil, with respect to the excited pipeline. The induced voltage level will depend on the soil characteristics, the distance from the excited pipeline, and the probe types. If liquid should leak from the excited pipeline, the escaping liquid will modify the induced potential of the soil surrounding the excited pipeline. This will change the response of the quiescent soil characteristics and cause the voltage level on the detecting probes in the area of the leak to increase. This voltage increase will indicate a soil anomaly. However, the liquid does not have to reach the detection probe to reveal an anomalous soil condition. Several different detection probes were used and evaluated for sensitivity and response time. Although not evaluated during this test, results indicate that a wire laid parallel to the pipe axis may be the best probe configuration. A general sensitivity figure for any of the probes cannot be made from these tests; however, the technique used will reliably detect a pipeline leak of ten gallons. An additional test was performed using the Boeing pipeline leak detection technique to locate the position and depth of an underground pipeline. This test showed that the location and depth of an excited pipeline could be determined from above the ground where other methods for pipeline location had previously failed

  17. Mutation analysis of the COL1A1 and COL1A2 genes in Vietnamese patients with osteogenesis imperfecta

    OpenAIRE

    Ho Duy, Binh; Zhytnik, Lidiia; Maasalu, Katre; Kändla, Ivo; Prans, Ele; Reimann, Ene; Märtson, Aare; Kõks, Sulev

    2016-01-01

    Background: The genetics of osteogenesis imperfecta (OI) have not been studied in a Vietnamese population before. We performed mutational analysis of the COL1A1 and COL1A2 genes in 91 unrelated OI patients of Vietnamese origin. We then systematically characterized the mutation profiles of these two genes which are most commonly related to OI.Methods: Genomic DNA was extracted from EDTA-preserved blood according to standard high-salt extraction methods. Sequence analysis and pathogenic variant...

  18. Crash Simulation of a Boeing 737 Fuselage Section Vertical Drop Test

    Science.gov (United States)

    Fasanella, Edwin L.; Jackson, Karen E.; Jones, Yvonne T.; Frings, Gary; Vu, Tong

    2004-01-01

    A 30-ft/s vertical drop test of a fuselage section of a Boeing 737 aircraft was conducted in October of 1999 at the FAA Technical Center in Atlantic City, NJ. This test was performed to evaluate the structural integrity of a conformable auxiliary fuel tank mounted beneath the floor and to determine its effect on the impact response of the airframe structure and the occupants. The test data were used to compare with a finite element simulation of the fuselage structure and to gain a better understanding of the impact physics through analytical/experimental correlation. To perform this simulation, a full-scale 3-dimensional finite element model of the fuselage section was developed using the explicit, nonlinear transient-dynamic finite element code, MSC.Dytran. The emphasis of the simulation was to predict the structural deformation and floor-level acceleration responses obtained from the drop test of the B737 fuselage section with the auxiliary fuel tank.

  19. Failure forecast of Boeing 737 bleed air system using artificial neural networks

    Science.gov (United States)

    Al-Wadiee, Waheed

    In this study, the failure rate of different types of bleed air control valves for the Boeing 737 aircraft is modeled. Two approaches are utilized to perform this work. In the first approach, Weibull model, in which different parameters are utilized and tested, is used. In the second one, a common type of the Artificial Neural Network (ANN) modeling is used. A Feed-forward back-propagation algorithm is implemented to train the network. Subsequently, the optimum number of neurons and layers that give the best result compared to the actual data are determined. Finally, the outputs from both models are compared against the actual data. The final results show a high level of accuracy of the ANN's predictions compared to the more traditional Weibull modeling. The developed verified model lends itself to applications that extend from scheduling replacements operations of these valves, to developing plans for inventory management in any aviation engines maintenance facility.

  20. Polymorphism analysis of COL4A3 and COL4A4 genes in Greek patients with keratoconus.

    Science.gov (United States)

    Kokolakis, Nikolaos S; Gazouli, Maria; Chatziralli, Irini P; Koutsandrea, Chryssanthi; Gatzioufas, Zisis; Peponis, Vasileios G; Droutsas, Konstantinos D; Kalogeropoulos, Christos; Anagnou, Nicholas; Miltsakakis, Dimitrios; Moschos, Marilita M

    2014-12-01

    In this study, we conducted the genotyping of D326Y in COL4A3 and M1327V, as well as F1644F in COL4A4 polymorphisms, in a case-control sample panel of Greek origin population. A case-control panel, with 45 keratoconus (KC) patients and 78 healthy controls, were surveyed. DNA from each individual was tested for the D326Y in COL4A3 and M1327V, as well as F1644F in COL4A4 polymorphisms by direct sequencing. When analyzing the Hardy-Weinberg equilibrium, we observed no significant deviation from expected numbers in both KC patients and controls. The genotype frequencies in the polymorphisms tested were not found to be significantly associated with KC development risk. The M1327V AA and F1644F TT genotypes were significantly over-represented in healthy individuals. We could hypothesize that mutations in COL4A3 and COL4A4 genes are not involved in KC risk in Greek population. Nevertheless, the M1327V AA and F1644F TT genotypes were significantly over-represented in healthy individuals, suggesting a protective role of these genotypes in KC development risk in our population.

  1. 77 FR 54856 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-09-06

    ... evaluation of structure'') of the FARs (14 CFR 25.571). During the reassessment, members of the airline industry participated with Boeing in working group sessions and developed the SSIP for Model 727, 727C, 727...

  2. Airport Pavement Design For The Boeing 777 Airplane

    Science.gov (United States)

    1995-10-22

    The purpose of this advisory circular is to provide thickness design standards : for pavements intended to serve the Boeing 777 airplane. A new method of design : based on layered elastic analysis has been developed to calculate design : thickness fo...

  3. 78 FR 61161 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-10-03

    ... new airworthiness directive (AD) for certain The Boeing Company Model DC-10-10 and MD-10-10F airplanes... reinstallation of a reduced life bolt on other Model DC-10-10 and MD-10-10 airplanes. Subsequent paragraphs have...) Applicability This AD applies to The Boeing Company Model DC-10-10 and MD-10- 10F airplanes, certificated in any...

  4. CID Aircraft slap-down

    Science.gov (United States)

    1984-01-01

    In this photograph the B-720 is seen during the moments of initial impact. The left wing is digging into the lakebed while the aircraft continues sliding towards wing openers. In 1984 NASA Dryden Flight Research Facility and the Federal Aviation Administration (FAA) teamed-up in a unique flight experiment called the Controlled Impact Demonstration (CID). The test involved crashing a Boeing 720 aircraft with four JT3C-7 engines burning a mixture of standard fuel with an additive, Anti-misting Kerosene (AMK), designed to supress fire. In a typical aircraft crash, fuel spilled from ruptured fuel tanks forms a fine mist that can be ignited by a number of sources at the crash site. In 1984 the NASA Dryden Flight Research Facility (after 1994 a full-fledged Center again) and the Federal Aviation Administration (FAA) teamed-up in a unique flight experiment called the Controlled Impact Demonstration (CID), to test crash a Boeing 720 aircraft using standard fuel with an additive designed to supress fire. The additive, FM-9, a high-molecular-weight long-chain polymer, when blended with Jet-A fuel had demonstrated the capability to inhibit ignition and flame propagation of the released fuel in simulated crash tests. This anti-misting kerosene (AMK) cannot be introduced directly into a gas turbine engine due to several possible problems such as clogging of filters. The AMK must be restored to almost Jet-A before being introduced into the engine for burning. This restoration is called 'degradation' and was accomplished on the B-720 using a device called a 'degrader.' Each of the four Pratt & Whitney JT3C-7 engines had a 'degrader' built and installed by General Electric (GE) to break down and return the AMK to near Jet-A quality. In addition to the AMK research the NASA Langley Research Center was involved in a structural loads measurement experiment, which included having instrumented dummies filling the seats in the passenger compartment. Before the final flight on December 1

  5. Cloning, Purification and Characterization of the Collagenase ColA Expressed by Bacillus cereus ATCC 14579.

    Directory of Open Access Journals (Sweden)

    Carmen M Abfalter

    Full Text Available Bacterial collagenases differ considerably in their structure and functions. The collagenases ColH and ColG from Clostridium histolyticum and ColA expressed by Clostridium perfringens are well-characterized collagenases that cleave triple-helical collagen, which were therefore termed as ´true´ collagenases. ColA from Bacillus cereus (B. cereus has been added to the collection of true collagenases. However, the molecular characteristics of B. cereus ColA are less understood. In this study, we identified ColA as a secreted true collagenase from B. cereus ATCC 14579, which is transcriptionally controlled by the regulon phospholipase C regulator (PlcR. B. cereus ATCC 14579 ColA was cloned to express recombinant wildtype ColA (ColAwt and mutated to a proteolytically inactive (ColAE501A version. Recombinant ColAwt was tested for gelatinolytic and collagenolytic activities and ColAE501A was used for the production of a polyclonal anti-ColA antibody. Comparison of ColAwt activity with homologous proteases in additional strains of B. cereus sensu lato (B. cereus s.l. and related clostridial collagenases revealed that B. cereus ATCC 14579 ColA is a highly active peptidolytic and collagenolytic protease. These findings could lead to a deeper insight into the function and mechanism of bacterial collagenases which are used in medical and biotechnological applications.

  6. Cloning, Purification and Characterization of the Collagenase ColA Expressed by Bacillus cereus ATCC 14579.

    Science.gov (United States)

    Abfalter, Carmen M; Schönauer, Esther; Ponnuraj, Karthe; Huemer, Markus; Gadermaier, Gabriele; Regl, Christof; Briza, Peter; Ferreira, Fatima; Huber, Christian G; Brandstetter, Hans; Posselt, Gernot; Wessler, Silja

    2016-01-01

    Bacterial collagenases differ considerably in their structure and functions. The collagenases ColH and ColG from Clostridium histolyticum and ColA expressed by Clostridium perfringens are well-characterized collagenases that cleave triple-helical collagen, which were therefore termed as ´true´ collagenases. ColA from Bacillus cereus (B. cereus) has been added to the collection of true collagenases. However, the molecular characteristics of B. cereus ColA are less understood. In this study, we identified ColA as a secreted true collagenase from B. cereus ATCC 14579, which is transcriptionally controlled by the regulon phospholipase C regulator (PlcR). B. cereus ATCC 14579 ColA was cloned to express recombinant wildtype ColA (ColAwt) and mutated to a proteolytically inactive (ColAE501A) version. Recombinant ColAwt was tested for gelatinolytic and collagenolytic activities and ColAE501A was used for the production of a polyclonal anti-ColA antibody. Comparison of ColAwt activity with homologous proteases in additional strains of B. cereus sensu lato (B. cereus s.l.) and related clostridial collagenases revealed that B. cereus ATCC 14579 ColA is a highly active peptidolytic and collagenolytic protease. These findings could lead to a deeper insight into the function and mechanism of bacterial collagenases which are used in medical and biotechnological applications.

  7. Amphibious Aircraft

    Data.gov (United States)

    National Aeronautics and Space Administration — A brief self composed research article on Amphibious Aircrafts discussing their use, origin and modern day applications along with their advantages and disadvantages...

  8. Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction.

    Directory of Open Access Journals (Sweden)

    Wei Yang

    2016-07-01

    Full Text Available Genome-wide association studies have revealed an association between coronary heart disease (CHD and genetic variation on chromosome 13q34, with the lead single nucleotide polymorphism rs4773144 residing in the COL4A2 gene in this genomic region. We investigated the functional effects of this genetic variant. Analyses of primary cultures of vascular smooth muscle cells (SMCs and endothelial cells (ECs from different individuals showed a difference between rs4773144 genotypes in COL4A2 and COL4A1 expression levels, being lowest in the G/G genotype, intermediate in A/G and highest in A/A. Chromatin immunoprecipitation followed by allelic imbalance assays of primary cultures of SMCs and ECs that were of the A/G genotype revealed that the G allele had lower transcriptional activity than the A allele. Electrophoretic mobility shift assays and luciferase reporter gene assays showed that a short DNA sequence encompassing the rs4773144 site interacted with a nuclear protein, with lower efficiency for the G allele, and that the G allele sequence had lower activity in driving reporter gene expression. Analyses of cultured SMCs from different individuals demonstrated that cells of the G/G genotype had higher apoptosis rates. Immunohistochemical and histological examinations of ex vivo atherosclerotic coronary arteries from different individuals disclosed that atherosclerotic plaques with the G/G genotype had lower collagen IV abundance and thinner fibrous cap, a hallmark of unstable, rupture-prone plaques. A study of a cohort of patients with angiographically documented coronary artery disease showed that patients of the G/G genotype had higher rates of myocardial infarction, a phenotype often caused by plaque rupture. These results indicate that the CHD-related genetic variant at the COL4A2 locus affects COL4A2/COL4A1 expression, SMC survival, and atherosclerotic plaque stability, providing a mechanistic explanation for the association between the genetic

  9. B-52 Launch Aircraft in Flight

    Science.gov (United States)

    2001-01-01

    the development of parachute recovery systems used to recover the space shuttle solid rocket booster casings. It also supported eight orbiter (space shuttle) drag chute tests in 1990. In addition, the B-52 served as the air launch platform for the first six Pegasus space boosters. During its many years of service, the B-52 has undergone several modifications. The first major modification was made by North American Aviation (now part of Boeing) in support of the X-15 program. This involved creating a launch-panel-operator station for monitoring the status of the test vehicle being carried, cutting a large notch in the right inboard wing flap to accommodate the vertical tail of the X-15 aircraft, and installing a wing pylon that enables the B-52 to carry research vehicles and test articles to be air-launched/dropped. Located on the right wing, between the inboard engine pylon and the fuselage, this wing pylon was subjected to extensive testing prior to its use. For each test vehicle the B-52 carried, minor changes were made to the launch-panel operator's station. Built originally by the Boeing Company, the NASA B-52 is powered by eight Pratt & Whitney J57-19 turbojet engines, each of which produce 12,000 pounds of thrust. The aircraft's normal launch speed has been Mach 0.8 (about 530 miles per hour) and its normal drop altitude has been 40,000 to 45,000 feet. It is 156 feet long and has a wing span of 185 feet.

  10. Design and evaluation of aircraft heat source systems for use with high-freezing point fuels

    Science.gov (United States)

    Pasion, A. J.

    1979-01-01

    The objectives were the design, performance and economic analyses of practical aircraft fuel heating systems that would permit the use of high freezing-point fuels on long-range aircraft. Two hypothetical hydrocarbon fuels with freezing points of -29 C and -18 C were used to represent the variation from current day jet fuels. A Boeing 747-200 with JT9D-7/7A engines was used as the baseline aircraft. A 9300 Km mission was used as the mission length from which the heat requirements to maintain the fuel above its freezing point was based.

  11. Aircraft Carriers

    DEFF Research Database (Denmark)

    Nødskov, Kim; Kværnø, Ole

    as their purchases of aircraft carrier systems, makes it more than likely that the country is preparing such an acquisition. China has territorial disputes in the South China Sea over the Spratly Islands and is also worried about the security of its sea lines of communications, by which China transports the majority...... of its foreign trade, as well as its oil imports, upon which the country is totally dependent. China therefore has good reasons for acquiring an aircraft carrier to enable it to protect its national interests. An aircraft carrier would also be a prominent symbol of China’s future status as a great power......, then the country will also acquire the capability to project military power into the region beyond Taiwan, which it does not possess today. In this way, China will have the military capability to permit a change of strategy from the mainly defensive, mainland, Taiwan-based strategy to a more assertive strategy...

  12. Tuberculose du col utérin simulant un cancer du col utérin : à propos ...

    African Journals Online (AJOL)

    Tuberculose du col utérin simulant un cancer du col utérin : à propos d'un cas, au Centre Hospitalier Universitaire Souro Sanou de Bobo-Dioulasso, Burkina Faso. A. Dembélé, V. Konségré, E. Birba, D.A. Somé, H. Zamané, A.S. Ouédraogo, S. Kiemtoré, S. Ouattara, A. Lamien-Sanou, M. Bambara, B. Bonané/Thiéba ...

  13. Experimental and Computational Sonic Boom Assessment of Boeing N+2 Low Boom Models

    Science.gov (United States)

    Durston, Donald A.; Elmiligui, Alaa; Cliff, Susan E.; Winski, Courtney S.; Carter, Melissa B.; Walker, Eric L.

    2015-01-01

    Near-field pressure signatures were measured and computational predictions made for several sonic boom models representing Boeing's Quiet Experimental Validation Concept (QEVC) supersonic transport, as well as three axisymmetric calibration models. Boeing developed the QEVC under a NASA Research Announcement (NRA) contract for Experimental Systems Validations for N+2 Supersonic Commercial Transport Aircraft, which was led by the NASA High Speed Project under the Fundamental Aeronautics Program. The concept was designed to address environmental and performance goals given in the NRA, specifically for low sonic boom loudness levels and high cruise efficiency, for an aircraft anticipated to enter service in the 2020 timeframe. Wind tunnel tests were conducted on the aircraft and calibration models during Phases I and II of the NRA contract from 2011 to 2013 in the NASA Ames 9- by 7-Foot and NASA Glenn 8- by 6-Foot Supersonic Wind Tunnels. Sonic boom pressure signatures were acquired primarily at Mach 1.6 and 1.8, and force and moment data were acquired from Mach 0.8 to 1.8. The sonic boom test data were obtained using a 2-in. flat-top pressure rail and a 14-in. round-top tapered "reflection factor 1" (RF1) pressure rail. Both rails capture an entire pressure signature in one data point, and successive signatures at varying positions along or above the rail were used to improve data quality through spatial averaging. The sonic boom data obtained by the rails were validated with high-fidelity numerical simulations of off-body pressures using the CFD codes USM3D, Cart3D, and OVERFLOW. The test results from the RF1 rail showed good agreement between the computational and experimental data when a variety of testing techniques including spatial averaging of a series of pressure signatures were employed, however, reflections off the 2-in. flat-top rail caused distortions in the signatures that did not agree with the CFD predictions. The 9 x 7 and 8 x 6 wind tunnels generally

  14. V-22 Osprey Joint Services Advanced Vertical Lift Aircraft (V-22)

    Science.gov (United States)

    2015-12-01

    Selected Acquisition Report (SAR) RCS: DD-A&T(Q&A)823-212 V-22 Osprey Joint Services Advanced Vertical Lift Aircraft (V-22) As of FY 2017...Logistics) V-22 December 2015 SAR March 21, 2016 12:02:38 UNCLASSIFIED 4 Col Dan Robinson PMA-275 (V-22 Osprey Joint Services Advanced Vertical Lift...Information Program Name V-22 Osprey Joint Services Advanced Vertical Lift Aircraft (V-22) DoD Component Navy Joint Participants United States

  15. Complete COL1A1 allele deletions in osteogenesis imperfecta

    NARCIS (Netherlands)

    van Dijk, Fleur S.; Huizer, Margriet; Kariminejad, Ariana; Marcelis, Carlo L.; Plomp, Astrid S.; Terhal, Paulien A.; Meijers-Heijboer, Hanne; Weiss, Marjan M.; van Rijn, Rick R.; Cobben, Jan M.; Pals, Gerard

    2010-01-01

    To identify a molecular genetic cause in patients with a clinical diagnosis of osteogenesis imperfecta (OI) type I/IV. The authors performed multiplex ligation-dependent probe amplification analysis of the COL1A1 gene in a group of 106 index patients. In four families with mild osteogenesis

  16. Complete COL1A1 allele deletions in osteogenesis imperfecta

    NARCIS (Netherlands)

    van Dijk, Fleur S.; Huizer, Margriet; Kariminejad, Ariana; Marcelis, Carlo L.; Plomp, Astrid S.; Terhal, Paulien A.; Meijers-Heijboer, Hanne; Weiss, Marjan M.; van Rijn, Rick R.; Cobben, Jan M.; Pals, Gerard

    2010-01-01

    Purpose: To identify a molecular genetic cause in patients with a clinical diagnosis of osteogenesis imperfecta (OI) type I/IV. Methods: The authors performed multiplex ligation-dependent probe amplification analysis of the COL1A1 gene in a group of 106 index patients. Results: In four families with

  17. EuroCirCol: A key to New Physics

    CERN Multimedia

    Johannes Gutleber

    2015-01-01

    Monday 1 June saw the start of EuroCirCol, the EC-funded part of the FCC study that will develop the conceptual design for an energy-frontier hadron collider.   Attendees at the EuroCirCol meeting at CERN. The EuroCirCol kick-off event at CERN on 2 to 4 June brought together 62 participants to constitute governance bodies, commit to the project plan and align the organisation, structures and processes of 16 institutions from 10 countries. The goal of the project is to conceive a post-LHC research infrastructure around a 100 km circular energy-frontier hadron collider capable of reaching 100 TeV collisions. The project officially started on 1 June and will run for four years. The total estimated budget of 11.2 MEUR includes a 2.99 MEUR contribution from the Horizon 2020 programme dedicated to the development of new world-class research infrastructures. EuroCirCol will deliver a design for a hadron collider as part of the broader Future Circular Collider (FCC) study. It will provide input to an...

  18. Resistance ability evaluation of safety-related structures for the simulated aircraft accident

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Jin; Kim, Sung Woon; Choi, Jang Kyu [Daewoo E and C Co., Ltd., Suwon (Korea, Republic of)] (and others)

    2003-03-15

    Aircraft accidents on nuclear safety-related structures can cause severe damage to the safety of NPP(Nuclear Power Plant)s. To assess the safety of nuclear safety-related structures, the local damage and the dynamic response of global structures should be investigated together. This study have compared several local damage assessment formulas suggested for aircraft as an impactor, and have set the assessment system of local damage for impact-proof design of NPP containment buildings. And the local damage of nuclear safety-related structures in operation in Korea for commercial aircraft as impactor have been estimated. Impact load-time functions of the aircraft crash have been decided to assessment the safety of nuclear safety-related structures against the intentional colliding of commercial aircraft. Boeing 747 and Boeing 767 is selected as target aircraft based on the operation frequencies and weights. Comparison of the fire analysis methods showed that the method considering heat convection and radiation is adequate for the temperature analysis of the aircraft fuel fire. Finally, the study covered the analysis of the major structural drawings and design drawings with which three-dimensional finite element model analysis is expected to be performed.

  19. Structural analysis at aircraft conceptual design stage

    Science.gov (United States)

    Mansouri, Reza

    In the past 50 years, computers have helped by augmenting human efforts with tremendous pace. The aircraft industry is not an exception. Aircraft industry is more than ever dependent on computing because of a high level of complexity and the increasing need for excellence to survive a highly competitive marketplace. Designers choose computers to perform almost every analysis task. But while doing so, existing effective, accurate and easy to use classical analytical methods are often forgotten, which can be very useful especially in the early phases of the aircraft design where concept generation and evaluation demands physical visibility of design parameters to make decisions [39, 2004]. Structural analysis methods have been used by human beings since the very early civilization. Centuries before computers were invented; the pyramids were designed and constructed by Egyptians around 2000 B.C, the Parthenon was built by the Greeks, around 240 B.C, Dujiangyan was built by the Chinese. Persepolis, Hagia Sophia, Taj Mahal, Eiffel tower are only few more examples of historical buildings, bridges and monuments that were constructed before we had any advancement made in computer aided engineering. Aircraft industry is no exception either. In the first half of the 20th century, engineers used classical method and designed civil transport aircraft such as Ford Tri Motor (1926), Lockheed Vega (1927), Lockheed 9 Orion (1931), Douglas DC-3 (1935), Douglas DC-4/C-54 Skymaster (1938), Boeing 307 (1938) and Boeing 314 Clipper (1939) and managed to become airborne without difficulty. Evidencing, while advanced numerical methods such as the finite element analysis is one of the most effective structural analysis methods; classical structural analysis methods can also be as useful especially during the early phase of a fixed wing aircraft design where major decisions are made and concept generation and evaluation demands physical visibility of design parameters to make decisions

  20. 77 FR 18719 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-03-28

    ... Boeing Company Model DC-10-10, DC-10- 10F, DC-10-15, DC-10-30, DC-10-30F (KC-10A and KDC-10), DC-10-40, DC- 10-40F, MD-10-10F, and MD-10-30F airplanes. The existing AD currently requires installing or..., December 31, 2009), for certain Boeing Model DC-10-10, DC- ] 10-10F, DC-10-15, DC-10-30, DC-10-30F (KC-10A...

  1. Boeing 120 MeV RF linac for FEL research

    International Nuclear Information System (INIS)

    Adamski, J.L.; Gallagher, W.J.; Kennedy, R.C.; Robinson, B.; Shoffstall, D.R.; Tyson, E.L.; Vetter, A.M.; Yeremian, A.D.

    1985-01-01

    A new electron linac for high power, visible wavelength, free electron laser research is under construction at the Boeing Radiation Laboratory in Seattle. The linac is a five section, traveling wave, L band structure with a specialized comb pulse format of widely separated high charge micropulses. The paper describes the accelerator design and prototyping of key components of the linac. These include a double subharmonic injector and a long pulse phase and amplitude stabilized RF source which have been tested on Boeing's 20 MeV S band linac

  2. Life cycle cost analysis of aging aircraft airframe maintenance

    Science.gov (United States)

    Sperry, Kenneth Robert

    Scope and method of study. The purpose of this study was to examine the relationship between an aircraft's age and its annual airframe maintenance costs. Common life cycle costing methodology has previously not recognized the existence of this cost growth potential, and has therefor not determined the magnitude nor significance of this cost element. This study analyzed twenty-five years of DOT Form 41-airframe maintenance cost data for the Boeing 727, 737, 747 and McDonnell Douglas DC9 and DC-10 aircraft. Statistical analysis included regression analysis, Pearson's r, and t-tests to test the null hypothesis. Findings and conclusion. Airframe maintenance cost growth was confirmed to be increasing after an aircraft's age exceeded its designed service objective of approximately twenty-years. Annual airframe maintenance cost growth increases were measured ranging from 3.5% annually for a DC-9, to approximately 9% annually for a DC-10 aircraft. Average measured coefficient of determination between age and airframe maintenance, exceeded .80, confirming a strong relationship between cost: and age. The statistical significance of the difference between airframe costs sampled in 1985, compared to airframe costs sampled in 1998 was confirmed by t-tests performed on each subject aircraft group. Future cost forecasts involving aging aircraft subjects must address cost growth due to aging when attempting to model an aircraft's economic service life.

  3. Finite-difference modeling of commercial aircraft using TSAR

    Energy Technology Data Exchange (ETDEWEB)

    Pennock, S.T.; Poggio, A.J.

    1994-11-15

    Future aircraft may have systems controlled by fiber optic cables, to reduce susceptibility to electromagnetic interference. However, the digital systems associated with the fiber optic network could still experience upset due to powerful radio stations, radars, and other electromagnetic sources, with potentially serious consequences. We are modeling the electromagnetic behavior of commercial transport aircraft in support of the NASA Fly-by-Light/Power-by-Wire program, using the TSAR finite-difference time-domain code initially developed for the military. By comparing results obtained from TSAR with data taken on a Boeing 757 at the Air Force Phillips Lab., we hope to show that FDTD codes can serve as an important tool in the design and certification of U.S. commercial aircraft, helping American companies to produce safe, reliable air transportation.

  4. Comprehensive analysis of transport aircraft flight performance

    Science.gov (United States)

    Filippone, Antonio

    2008-04-01

    This paper reviews the state-of-the art in comprehensive performance codes for fixed-wing aircraft. The importance of system analysis in flight performance is discussed. The paper highlights the role of aerodynamics, propulsion, flight mechanics, aeroacoustics, flight operation, numerical optimisation, stochastic methods and numerical analysis. The latter discipline is used to investigate the sensitivities of the sub-systems to uncertainties in critical state parameters or functional parameters. The paper discusses critically the data used for performance analysis, and the areas where progress is required. Comprehensive analysis codes can be used for mission fuel planning, envelope exploration, competition analysis, a wide variety of environmental studies, marketing analysis, aircraft certification and conceptual aircraft design. A comprehensive program that uses the multi-disciplinary approach for transport aircraft is presented. The model includes a geometry deck, a separate engine input deck with the main parameters, a database of engine performance from an independent simulation, and an operational deck. The comprehensive code has modules for deriving the geometry from bitmap files, an aerodynamics model for all flight conditions, a flight mechanics model for flight envelopes and mission analysis, an aircraft noise model and engine emissions. The model is validated at different levels. Validation of the aerodynamic model is done against the scale models DLR-F4 and F6. A general model analysis and flight envelope exploration are shown for the Boeing B-777-300 with GE-90 turbofan engines with intermediate passenger capacity (394 passengers in 2 classes). Validation of the flight model is done by sensitivity analysis on the wetted area (or profile drag), on the specific air range, the brake-release gross weight and the aircraft noise. A variety of results is shown, including specific air range charts, take-off weight-altitude charts, payload-range performance

  5. 77 FR 69747 - Airworthiness Directives; The Boeing Company Model Airplanes

    Science.gov (United States)

    2012-11-21

    ....'' SWA states that this would eliminate any confusion as to whether the subject inspection is to be done... 737-600 is a next generation (NG) airplane, not a 737 ``Classic'' airplane. Boeing also asked that the.... operators airplanes Various inspections (retained 4 work-hours x $85 per $0 $340 per inspection 296 $100,640...

  6. 77 FR 50577 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-08-22

    ... is a grammatical error. We agree with the commenters' requests. We inadvertently specified ``total... by the AD. We have made no change to the AD in this regard. Request To Correct Grammatical Errors Boeing asked that we correct grammatical errors in the ``Differences'' and ``Relevant Service Information...

  7. 78 FR 14934 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-03-08

    .... Request To Correct Certain Paragraph Identifiers United Airlines (UAL), Japan Airlines (JAL), and UPS... changed the second SNPRM in this regard. Request To Clarify Certain Language in the ``Comments'' Section of the First SNPRM (77 FR 39188, July 2, 2012) Boeing asked that the language in the ``Comments...

  8. 77 FR 38547 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-06-28

    ... cracking, misdrilled fastener holes, elongated fastener holes, corrosion, oil-cans, and existing repairs..., corrosion, oil-cans, and existing repairs), or for certain discrepancies, contacting Boeing for repair... Designated Engineering Representative (DER). We have revised the date of the document specified in paragraph...

  9. 77 FR 40828 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-07-11

    ...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model DC-10-10 and MD-10-10F airplanes. This proposed AD was prompted by a report that the safe life limit on...-140, 1200 New Jersey Avenue SE., Washington, DC 20590. Hand Delivery: Deliver to Mail address above...

  10. Boeing vallandas ebaeetilise finantsjuhi / Annika Matson, Raivo Sormunen

    Index Scriptorium Estoniae

    Matson, Annika, 1976-

    2003-01-01

    USA lennukitootja Boeing finantsjuht Mike Sears vallandati USA Õhujõududes hankespetsialistina töötanud Darleen Druyuni palkamise ning sel viisil Boeingut puudutavate lepingute mõjutamise tõttu. Diagramm: Boeingu käive kannatab skandaali tõttu

  11. Boeing to Rank Colleges by Measuring Graduates' Job Success

    Science.gov (United States)

    Basken, Paul

    2008-01-01

    Boeing Company, the Chicago-based aerospace giant, has spent the past year matching internal data from employee evaluations with information about the colleges its engineers attended. It has used that analysis to create a ranking system, which it plans to unveil in the coming month, that will show which colleges have produced the workers it…

  12. Gezondheidsrisico's brand EL AL-Boeing

    NARCIS (Netherlands)

    van Bruggen M; Janssen PJCM; Kliest JJG; Meulenbelt J; Smetsers RCGM; Uijt de Haag PAM; de Mik G; Elzinga G; IEM; CSR; VIC; LSO; SB4; DIR

    1998-01-01

    Op verzoek van het ministerie van VWS heeft het RIVM onderzoek verricht naar mogelijke gezondheidsrisico's van de verbranding of verspreiding van stoffen en goederen die zich aan boord bevonden van de in 1992 verongelukte El Al-Boeing. Allereerst heeft het RIVM de in de ladinglijst genoemde

  13. With Direct Contracting Boeing Cuts Out the Middleman.

    Science.gov (United States)

    Burns, Joseph

    2017-11-01

    The company has more than 15,000 employees - or about a third of the eligible employees in those four locations - enrolled in direct contracts. Boeing has dubbed the direct contracts its Preferred Partnership health plan. Should insurers worry that other large companies will cut them out?

  14. The Boeing Company's Manufacturing Technology Student Internship. Evaluation Report.

    Science.gov (United States)

    Owens, Thomas R.

    The Boeing Company contracted with the Northwest Regional Educational Laboratory to evaluate its student internship program, part of a "school-to-work" effort modeled after the nationally recognized Tech Prep initiative. The company's involvement in the Tech Prep Program has been implemented in three phases: (1) the initial phase helped…

  15. 77 FR 31758 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2012-05-30

    ... the loss of automatic speed control, and consequent loss of control of the airplane. Since the... are reopening the comment period to allow the public the chance to comment on this proposed change... and the loss of automatic speed control, and may lead to loss of control of the airplane.'' Boeing...

  16. 78 FR 6200 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-01-30

    ... FR 11416, February 27, 2012) and replace the words ``other products of this same type design'' in the paragraph ``FAA's Determination,'' with the words ``the Boeing 737 Next Generation (737NG) airplane prior to... significant economic impact, positive or negative, on a substantial number of small entities under the...

  17. Tras la estela de Colón

    OpenAIRE

    Carmen Martínez Martin

    2011-01-01

    El más trascendental y conocido de los viajes de exploración llevado a cabo en la era de los grandes descubrimientos fue el protagonizado por Cristóbal Colón, quien, con el apoyo de la corona de Castilla, logró atravesar el océano Atlántico y descubrir el nuevo mundo.

  18. On display during a technical exposition at NASA Dryden are L to R: Boeing's X-37, the flight-articl

    Science.gov (United States)

    2000-01-01

    Aerospace industry representatives view actual and mock-up versions of 'X-Planes' intended to enhance access to space during a technical exposition on June 22, 2000 at Dryden Flight Research Center, Edwards, California. From left to right: NASA's B-52 launch aircraft, in service with NASA since 1959; a neutral-buoyancy model of the Boeing's X-37; the Boeing X-40A behind the MicroCraft X-43 mock-up; Orbital Science's X-34 and the modified Lockheed L-1011 airliner that was to launch the X-34. These X-vehicles are part of NASA's Access to Space plan intended to bring new technologies to bear in an effort to dramatically lower the cost of putting payloads in space, and near-space environments. The June 22, 2000 NASA Reusable Launch Vehicle (RLV) Technology Exposition included presentations on the history, present, and future of NASA's RLV program. Special Sessions for industry representatives highlighted the X-37 project and its related technologies. The X-37 project is managed by NASA's Marshall Space Flight Center, Huntsville, Alabama.

  19. VASCOMP 2. The V/STOL aircraft sizing and performance computer program. Volume 6: User's manual, revision 3

    Science.gov (United States)

    Schoen, A. H.; Rosenstein, H.; Stanzione, K.; Wisniewski, J. S.

    1980-01-01

    This report describes the use of the V/STOL Aircraft Sizing and Performance Computer Program (VASCOMP II). The program is useful in performing aircraft parametric studies in a quick and cost efficient manner. Problem formulation and data development were performed by the Boeing Vertol Company and reflects the present preliminary design technology. The computer program, written in FORTRAN IV, has a broad range of input parameters, to enable investigation of a wide variety of aircraft. User oriented features of the program include minimized input requirements, diagnostic capabilities, and various options for program flexibility.

  20. Dietary Lecithin Decreases Skeletal Muscle COL1A1 and COL3A1 Gene Expression in Finisher Gilts

    Directory of Open Access Journals (Sweden)

    Henny Akit

    2016-06-01

    Full Text Available The purpose of this study was to investigate the effect of dietary lecithin on skeletal muscle gene expression of collagen precursors and enzymes involved in collagen synthesis and degradation. Finisher gilts with an average start weight of 55.9 ± 2.22 kg were fed diets containing either 0, 4, 20 or 80 g/kg soybean lecithin prior to harvest for six weeks and the rectus abdominis muscle gene expression profile was analyzed by quantitative real-time PCR. Lecithin treatment down-regulated Type I (α1 procollagen (COL1A1 and Type III (α1 procollagen (COL3A1 mRNA expression ( p < 0.05, respectively, indicating a decrease in the precursors for collagen synthesis. The α-subunit of prolyl 4-hydroxylase (P4H mRNA expression also tended to be down-regulated ( p = 0.056, indicating a decrease in collagen synthesis. Decreased matrix metalloproteinase-1 (MMP-1 mRNA expression may reflect a positive regulatory response to the reduced collagen synthesis in muscle from the pigs fed lecithin ( p = 0.035. Lecithin had no effect on tissue inhibitor metalloproteinase-1 (TIMP-1, matrix metalloproteinase-13 (MMP-13 and lysyl oxidase mRNA expression. In conclusion, lecithin down-regulated COL1A1 and COL3A1 as well as tended to down-regulate α-subunit P4H expression. However, determination of muscle collagen content and solubility are required to support the gene functions.

  1. Damage assessment of nuclear containment against aircraft crash

    Energy Technology Data Exchange (ETDEWEB)

    Iqbal, Mohd Ashraf, E-mail: iqbal_ashraf@rediffmail.com; Sadique, Md. Rehan, E-mail: rehan.sadique@gmail.com; Bhargava, Pradeep, E-mail: bhpdpfce@iitr.ac.in; Bhandari, N.M., E-mail: nmbcefce@iitr.ac.in

    2014-10-15

    Highlights: • Damage assessment of nuclear containment is studied against aircraft crash. • Four impact locations have been identified at the outer containment shell. • The mid of the total height has been found to be most vulnerable location. • The crown of dome has been found to be the strongest location. • Phantom F4 caused more localized and severe damage compared to other aircrafts. - Abstract: The behavior of nuclear containment structure has been studied against aircraft crash with an emphasis on the influence of strike location. The impact locations identified on the BWR Mark III type nuclear containment structure are mid-height, junction of dome and cylinder, crown of dome and arc of dome. The containment at each of the above locations has been impacted normally by Phantom F-4, Boeing 707-320 and Airbus A320 aircrafts. The loading of the aircraft has been assigned through the corresponding reaction-time response curve. ABAQUS/Explicit finite element code has been used to carry out the three-dimensional numerical simulations. The concrete damaged plasticity model was used to simulate the behavior of concrete while the behavior of steel reinforcement was incorporated using the Johnson–Cook elasto-viscoplastic material model. The mid-height of containment has been found to experience most severe deformation against each aircraft. Phantom F4 has been found to be most disastrous at each location. The results have been compared with those of the available studies with respect to the containment deformation.

  2. Evolution of civil aircraft industry development

    Directory of Open Access Journals (Sweden)

    Aram I. Afyan

    2017-01-01

    Full Text Available Civil aircraft industry market is а complex multistage system of manufacturers and consumers, which affects countries all over the world. The globalization and world economic growth caused inevitable merger of national markets into one system where the key role belongs to few corporations. In the article the author analyze peculiarities of civil aircraft industry global market shaping. Main reasons of aircraft industry centers appearance are considered through socio political and economic development of the industry. Factors that caused national specialization of manufacturing countries are examined along with peculiarities of Boeing leadership. The main stages of the industry development are described starting from the beginning of the 20th century up to the present day. The author highlights specific characters of European manufacturers development and their merger into one multinational conglomerate. Besides, modern market status is examined through benchmark study of the main competitors. Main tendencies of the industry are segmentation and new aviation industry clusters appearance. Key actors of regional aviation are described, which are Embraer and Bombardier. Reasons of their appearance and development are analyzed. Main pretenders for the aviation industry global market entrance are outlined.

  3. COL9A2 and COL9A3 mutations in canine autosomal recessive Oculo-skeletal Dysplasia

    Science.gov (United States)

    Goldstein, Orly; Guyon, Richard; Kukekova, Anna; Pearce-Kelling, Sue; Johnson, Jennifer; Aguirre, Gustavo D.; Acland, Gregory M.

    2010-01-01

    Oculo-skeletal dysplasia segregates in two canine breeds, the Labrador retriever and samoyed, in which the causative loci have been termed drd1 and drd2, respectively. Affected dogs exhibit short-limbed dwarfism together with severe ocular defects, and this phenotype is inherited as an autosomal recessive trait in both breeds. The clinical and pathological appearance resembles human hereditary arthro-ophthalmopathies such as Stickler syndrome, or Marshall Syndrome, although these human disorders are usually dominant. Linkage studies in drd1-informative pedigrees mapped the locus to canine chromosome 24, and led to the identification of an insertional mutation in exon 1 of the gene COL9A3 that cosegregates with the disease. The drd2 locus was similarly mapped to canine chromosome 15 and shown to cosegregate with a 1,267 bp deletion mutation in the 5′ end of COL9A2. Both mutations affect the COL3 domain of the respective gene. Northern analysis showed reduced RNA expression in affected retina compared to normal. These models offer potential for studies such as protein-protein interactions between different members of the collagen gene family; regulation and expression of these genes in retina and cartilage, and even opportunities for gene therapy. PMID:20686772

  4. Aircraft Steels

    Science.gov (United States)

    2009-02-19

    70 mm (0.4 x 0.4 x 2.8 in.) in L orientation with a Charpy notch at the mid-length for SCC test under four-point bending (ASTM F 1624- 95) TESTS ...MAXIMUM STRESS INTENSITY, Kmax, IN HIGH STRENGTH STEELS For the fatigue test in 3.5% NaCl solution, the FCG per cycle, da/dN, is converted to the...NAWCADPAX/TR-2009/12 AIRCRAFT STEELS by E. U. Lee R. Taylor C. Lei H. C. Sanders 19 February 2009

  5. Acoustic Source Localization in Aircraft Interiors Using Microphone Array Technologies

    Science.gov (United States)

    Sklanka, Bernard J.; Tuss, Joel R.; Buehrle, Ralph D.; Klos, Jacob; Williams, Earl G.; Valdivia, Nicolas

    2006-01-01

    Using three microphone array configurations at two aircraft body stations on a Boeing 777-300ER flight test, the acoustic radiation characteristics of the sidewall and outboard floor system are investigated by experimental measurement. Analysis of the experimental data is performed using sound intensity calculations for closely spaced microphones, PATCH Inverse Boundary Element Nearfield Acoustic Holography, and Spherical Nearfield Acoustic Holography. Each method is compared assessing strengths and weaknesses, evaluating source identification capability for both broadband and narrowband sources, evaluating sources during transient and steady-state conditions, and quantifying field reconstruction continuity using multiple array positions.

  6. Specific problems concerning aircraft impact on nuclear containment vessels

    International Nuclear Information System (INIS)

    Fuzier, J.P.; Cheyrezy, M.H.; Dufour, C.J.

    1977-01-01

    Due to the high population density, in Belgium PWR power plants are designed against aircraft impacts (BOEING 707 crashing at 360 km per hour and STARFIGHTER F 104 G crashing at 540 km per hour). A double wall is used for the containment shield. The lack of relevant data and specifications for such a loading on the non-prestressed external wall led the authors to determine the suitable safety criteria, the most appropriate materials to be used and the corresponding limit state design through dynamic and plastic analysis. (Auth.)

  7. Mutation Analysis of COL1A1 and COL1A2 in Fetuses with Osteogenesis Imperfecta Type II/III.

    Science.gov (United States)

    Wang, Wenbo; Wu, Qichang; Cao, Lin; Sun, Li; Xu, Yasong; Guo, Qiwei

    2015-01-27

    Aim: To analyze COL1A1/2 mutations in prenatal-onset OI for determine the proportion of mutations in type I collagen genes among prenatal onset OI and to provide additional data for genotype-phenotype analyses. Material and Methods: Ten cases of severe fetal short-limb dwarfism detected by antenatal ultrasonography were referred to our center. Before the termination of pregnancy, cordocentesis was performed for fetal karyotype and COL1A1/2 gene sequencing analysis. Postmortem radiographic examination was performed at all instances for definitive diagnosis. Results: COL1A1 and COL1A2 SNP and mutations were identified in all the cases. Among these, one synonymous SNP and four synonymous SNPs were recognized in COL1A1/2, respectively, seven cases have distinct heterozygous mutations and six new COL1A1/2 gene mutations were identified. Conclusion: There has been substantial progress in the identification of the molecular defects responsible for skeletal dysplasias. With the constant increase in the number of identified mutations in COL1A1 and COL1A2, genotype-phenotype correlation is becoming increasingly pertinent. © 2015 S. Karger AG, Basel.

  8. Hull loss accident model for narrow body commercial aircraft

    Directory of Open Access Journals (Sweden)

    Somchanok Tiabtiamrat

    2010-10-01

    Full Text Available Accidents with narrow body aircraft were statistically evaluated covering six families of commercial aircraft includingBoeing B737, Airbus A320, McDonnell Douglas MD80, Tupolev TU134/TU154 and Antonov AN124. A risk indicator for eachflight phase was developed based on motion characteristics, duration time, and the presence of adverse weather conditions.The estimated risk levels based on these risk indicators then developed from the risk indicator. Regression analysis indicatedvery good agreement between the estimated risk level and the accident ratio of hull loss cases per number of delivered aircraft.The effect of time on the hull loss accident ratio per delivered aircraft was assessed for B737, A320 and MD80. Equationsrepresenting the effect of time on hull loss accident ratio per delivered aircraft were proposed for B737, A320, and MD80,while average values of hull loss accident ratio per delivered aircraft were found for TU134, TU154, and AN 124. Accidentprobability equations were then developed for each family of aircraft that the probability of an aircraft in a hull loss accidentcould be estimated for any aircraft family, flight phase, presence of adverse weather factor, hour of day, day of week, monthof year, pilot age, and pilot flight hour experience. A simplified relationship between estimated hull loss accident probabilityand unsafe acts by human was proposed. Numerical investigation of the relationship between unsafe acts by human andfatality ratio suggested that the fatality ratio in hull loss accident was dominated primarily by the flight phase media.

  9. Active Flow Control (AFC) and Insect Accretion and Mitigation (IAM) System Design and Integration on the Boeing 757 ecoDemonstrator

    Science.gov (United States)

    Alexander, Michael G.; Harris, F. Keith; Spoor, Marc A.; Boyland, Susannah R.; Farrell, Thomas E.; Raines, David M.

    2016-01-01

    This paper presents a systems overview of how the Boeing and NASA team designed, analyzed, fabricated, and integrated the Active Flow Control (AFC) technology and Insect Accretion Mitigation (IAM) systems on the Boeing 757 ecoDemonstrator. The NASA Environmentally Responsible Aviation (ERA) project partnered with Boeing to demonstrate these two technology systems on a specially outfitted Boeing 757 ecoDemonstrator during the spring of 2015. The AFC system demonstrated attenuation of flow separation on a highly deflected rudder and increased the side force generated. This AFC system may enable a smaller vertical tail to provide the control authority needed in the event of an engine failure during takeoff while still operating in a conventional manner over the rest of the flight envelope. The AFC system consisted of ducting to obtain air from the Auxiliary Power Unit (APU), a control valve to modulate the system mass flow, a heat exchanger to lower the APU air temperature, and additional ducting to deliver the air to the AFC actuators located on the vertical tail. The IAM system demonstrated how to mitigate insect residue adhesion on a wing's leading edge. Something as small as insect residue on a leading edge can cause turbulent wedges that interrupt laminar flow, resulting in an increase in drag and fuel use. The IAM system consisted of NASA developed Engineered Surfaces (ES) which were thin aluminum sheet substrate panels with coatings applied to the exterior. These ES were installed on slats 8 and 9 on the right wing of the 757 ecoDemonstrator. They were designed to support panel removal and installation in one crew shift. Each slat accommodated 4 panels. Both the AFC and IAM flight test were the culmination of several years of development and produced valuable data for the advancement of modern aircraft designs.

  10. Development of pressure containment and damage tolerance technology for composite fuselage structures in large transport aircraft

    Science.gov (United States)

    Smith, P. J.; Thomson, L. W.; Wilson, R. D.

    1986-01-01

    NASA sponsored composites research and development programs were set in place to develop the critical engineering technologies in large transport aircraft structures. This NASA-Boeing program focused on the critical issues of damage tolerance and pressure containment generic to the fuselage structure of large pressurized aircraft. Skin-stringer and honeycomb sandwich composite fuselage shell designs were evaluated to resolve these issues. Analyses were developed to model the structural response of the fuselage shell designs, and a development test program evaluated the selected design configurations to appropriate load conditions.

  11. Colágeno na cartilagem osteoartrótica

    Directory of Open Access Journals (Sweden)

    Ana Paula P. Velosa

    2003-06-01

    Full Text Available A cartilagem articular é um tecido altamente especializado, composto por células, os condrócitos, e um conjunto de macromoléculas, como o colágeno e os proteoglicanos. O colágeno é uma proteína fibrilar que garante resistência ao tecido, enquanto os proteoglicanos têm a função de mola biológica, sendo responsáveis pela compressibilidade da cartilagem. A complexa interação entre estas duas proteínas garante a elasticidade. Estas características específicas da cartilagem são essenciais para amortecer as grandes forças de impacto a que as articulações diartrodiais estão submetidas, sem muito gasto de energia, visto tratar-se de um tecido avascular. Em processos artrósicos ocorre um desequilíbrio entre a produção de componentes da matriz extracelular e destruição pelas metaloproteases, levando à degradação e perda do tecido cartilaginoso. A fase inicial da osteoartrose é marcada por perda de fragmentos de proteoglicanos para o líquido sinovial, aumento dos colágenos tipo II e tipo VI, aparecimento dos colágenos I e III, não típicos da cartilagem, e diminuição do colágeno tipo IX, que é importante para manter a integridade da matriz extracelular, além do entumescimento da cartilagem. Como conseqüência, a cartilagem perde suas características específicas, levando a alterações na função articular. A evolução da doença promove diminuição significativa das proteínas, até mesmo do colágeno tipo XI, que tem localização mais interna na estrutura da fibrila heterotípica, e, portanto levando até a exposição do osso. Até o momento, o tratamento da osteoartrose está baseado principalmente no controle da dor e/ou inflamação, não diminuindo ou impedindo a degradação da cartilagem articular. Neste aspecto a perspectiva de tratamento futuro da osteoartrose estaria na utilização de inibidores das metaloproteases associadas a condroprotetores interferindo no "turnover" da cartilagem e

  12. COL F.F. PIENAAR'S BOER WAR DIARY (PART I)

    OpenAIRE

    J. Picard

    2012-01-01

    In 1902, Filip Pienaar, a young Boer officer in exile at the Monastery of Tomar in Portugal, recorded his Boer war experiences. These were published by Methuen in 1902, under the title With Steyn and De Wet, The book was banned one month after publication, The author, Lt Col F.F. Pienaar, later joined the Union Defence Force, served in the German South West Africa Campaign and later became South Africa's first ambassador to Portugal in 1939, from where he also conducted correspondence with hi...

  13. Boes Skov prøveudgravningsrapport (trial excavation report)

    DEFF Research Database (Denmark)

    Løvschal, Mette; Vinter, Michael

    Formålet med den arkæologiske forundersøgelse på matrikel 2n var at tilvejebringe viden om, hvorvidt der var bevarede spor af bronze- jernalderbebyggelse, som kunne sættes i forbindelse med de registrerede oldtidsagre i Boes Skov, om en lokal forhøjning var rester af en nedpløjet gravhøj, samt i...

  14. Identification and characterization of CONSTANS-like (COL) gene family in upland cotton (Gossypium hirsutum L.).

    Science.gov (United States)

    Cai, Darun; Liu, Hui; Sang, Na; Huang, Xianzhong

    2017-01-01

    The CONSTANS/FLOWERING LOCUS T (CO/FT) regulon plays a central role in the control of flowering time in photoperiod-sensitive plants. Flowering time in wild cotton (Gossypium spp.) has strict photoperiod sensitivity, but domesticated cotton is day-neutral. Information on the molecular characterization of the CO and CO-like (COL) genes in cotton is very limited. In this study, we identified 42 COL homologs (GhCOLs) in the G. hirsutum genome, and many of them were previously unreported. We studied their chromosome distribution, phylogenetic relationships, and structures of genes and proteins. Our results showed that GhCOLs were classified into three groups, and 14 COLs in group I showed conserved structure when compared with other plants. Two homoeologous pairs, GhCOL1-A and GhCOL1-D in Group I, showed the highest sequence similarity to Arabidopsis thaliana CO and rice CO homologous gene Heading date1 (Hd1). Tissue-specific expression showed that 42 GhCOL genes may function as tissue-specific regulators in different cells or organs. We cloned and sequenced the 14 GhCOL genes in Group I related to flowering induction to study their diurnal expression pattern, and found that their expression showed distinct circadian regulation. Most of them peaked at dawn and decreased rapidly to their minima at dusk, then started to accumulate until following dawn under long- or short-day conditions. Transgenic study in the Arabidopsis co-2 mutant demonstrated that GhCOL1-A and GhCOL1-D fully rescued the late-flowering phenotype, whereas GhCOL3-A, GhCOL3-D, GhCOL7-A, and GhCOL7-D partially rescued the late-flowering phenotype, and the other five homoeologous pairs in Group I did not promote flowering. These results indicate that GhCOL1-A and GhCOL1-D were potential flowering inducers, and are candidate genes for research in flowering regulation in cotton.

  15. Identification and characterization of CONSTANS-like (COL gene family in upland cotton (Gossypium hirsutum L..

    Directory of Open Access Journals (Sweden)

    Darun Cai

    Full Text Available The CONSTANS/FLOWERING LOCUS T (CO/FT regulon plays a central role in the control of flowering time in photoperiod-sensitive plants. Flowering time in wild cotton (Gossypium spp. has strict photoperiod sensitivity, but domesticated cotton is day-neutral. Information on the molecular characterization of the CO and CO-like (COL genes in cotton is very limited. In this study, we identified 42 COL homologs (GhCOLs in the G. hirsutum genome, and many of them were previously unreported. We studied their chromosome distribution, phylogenetic relationships, and structures of genes and proteins. Our results showed that GhCOLs were classified into three groups, and 14 COLs in group I showed conserved structure when compared with other plants. Two homoeologous pairs, GhCOL1-A and GhCOL1-D in Group I, showed the highest sequence similarity to Arabidopsis thaliana CO and rice CO homologous gene Heading date1 (Hd1. Tissue-specific expression showed that 42 GhCOL genes may function as tissue-specific regulators in different cells or organs. We cloned and sequenced the 14 GhCOL genes in Group I related to flowering induction to study their diurnal expression pattern, and found that their expression showed distinct circadian regulation. Most of them peaked at dawn and decreased rapidly to their minima at dusk, then started to accumulate until following dawn under long- or short-day conditions. Transgenic study in the Arabidopsis co-2 mutant demonstrated that GhCOL1-A and GhCOL1-D fully rescued the late-flowering phenotype, whereas GhCOL3-A, GhCOL3-D, GhCOL7-A, and GhCOL7-D partially rescued the late-flowering phenotype, and the other five homoeologous pairs in Group I did not promote flowering. These results indicate that GhCOL1-A and GhCOL1-D were potential flowering inducers, and are candidate genes for research in flowering regulation in cotton.

  16. Study of the Engine Bird Ingestion Experience of the Boeing 737 Aircraft

    Science.gov (United States)

    1991-10-01

    BRAZIL S FGN 4700 0 4786 1 4888 1 14374 2 PVK PREVEZA/LEFKAS, GREECE N FGN 0 0 0 0 0 0 0 0 PVU PUERTO VALLARTA , MEXICO N FGN 880 0 888 0 540 0 2308 0 A...3 17604 0 18875 1 55447 4 PEK BEIJIN, P. R. CHINA N FGN 9169 2 9152 0 8951 0 27272 2 PEN PUERTO MALDONADO, PERU S FGN 0 0 92 0 64 0 156 0 PEN PENANG...1468 0 PLZ PORT ELIZABETH, SOUTH AFRICA S FGN 12531 1 14399 2 13797 3 40727 6 PMA PEMBA ISLAND, TANZANIA S FGN 8 0 0 0 0 0 8 0 PMC PUERTO MONtT, CHILE S

  17. Engine Bird Ingestion Experience of the Boeing 747 Aircraft - Expanded Data Base (October 1986 - September 1989).

    Science.gov (United States)

    1992-07-01

    0 0 0 0 PVR PUERTO VALLARTA , MEXICO N FGN 880 0 888 0 540 0 2308 0 A- 12 AIRPORT APTDEF HEMISPHR COMUS STGFY87 INGI STGFY88 ING2 STGFY89 ING3 STG737...2 PEN PUERTO MALDONADO, PERU S FGN 0 0 92 0 64 0 156 0 PEN PENANG, MALAYSIA N FGN 9062 2 9591 0 10330 0 28983 2 PER PERTH, WA, AUSTRALIA S FGN 1178 0...PEMBA ISLAND, TANZANIA S FGN 8 0 0 0 0 0 8 0 PMC PUERTO MONTT, CHILE S FGN 1400 0 1565 0 1861 0 4826 0 PHE PORTSMOUTH, UK N FGN 0 0 0 2 0 0 0 2 PM! PALMA

  18. Study of the Engine Bird Ingestion Experience of the Boeing 737 Aircraft

    Science.gov (United States)

    1989-10-01

    DEL DELHI. INOIA N NO -4- 15967 ODE STAPLETON INTL. DENVER. CO. USA N YES CO 112673 oFW DALLAS/FT WORTH. TX. USA N YES TX 51136 DHA DHAHRAN. SAUDI...4- 4- mR + 4- 4- YES RING BILLED GLL 11112 1 16.196-4 BID I 91D II OZ I CTY PRS AIRPOT LOE US ] KID ENGINE Be (5101 COE lTY POMM16 L A pYy TROL IrSD EM...0- + 14- t LIN LIN LNUE, KAMI, Wi YS T 9 + O -0- W NO NEDI BIRD + I -0- 4- 1 mGDOMA, MIA O JTO +-0- A 3-0- -0-4- NO + GLL 14106 I 10. B4- DHA ’)F0

  19. Statistical loads data for Boeing 737-400 aircraft in commercial operations

    Science.gov (United States)

    1998-08-01

    The primary objective of this research is to support the FAA Airborne Data Monitoring Systems Research Program by developing new and improved methods and criteria for processing and presenting large commercial transport airplane flight and ground loa...

  20. Study of the Engine Bird Ingestion Experience of the Boeing 737 Aircraft (October 1986- September 1988)

    Science.gov (United States)

    1990-05-01

    HKNA JOMO KENYATTA OVERCAST NONE SEVERAL 1 FAO FARO, PORTUGA CLEAR NONE IBZ IBIZA, SPAIN NONE 1 ABTL TOWNSVILLE, Ai CLEAR NONE ONE SPARROW* 1 BHX...PAKISTAN NO JT80 XUS YES JT8D LA LHR LONDON-HEATHROW, ENGLAND NO CFM56 3 k HKNA JOMO KENYATTA , KENYA NO JT80 1 FAO FARO, PORTUGAL NO JT8D IBZ IBIZA

  1. The global decentralization of commercial aircraft production: Implications for United States-based manufacturing activity

    Science.gov (United States)

    Pritchard, David John

    This research explores the role of industrial offset agreements and international subcontracting patterns in the global decentralization of US commercial aircraft production. Particular attention is given to the manufacturing processes involved in the design and assembly of large passenger jets (100 seats or more). It is argued that the current geography of aircraft production at the global level has been shaped by a new international distribution of input costs and technological capability. Specifically, low-cost producers within several of the newly emerging markets (NEMs) have acquired front-end manufacturing expertise as a direct result of industrial offset contracts and/or other forms of technology transfer (e.g. international joint-ventures, imports of advanced machine tools). The economic and technological implications of industrial offset (compensatory trade) are examined with reference to the commercial future of US aircraft production. Evidence gathered via personal interviews with both US and foreign producers suggests that the current Western duopoly (Boeing and Airbus) faces a rather uncertain future. In particular, the dissertation shows that the growth of subcontracting and industrial offset portends the transformation of Boeing from an aircraft manufacturer to a systems integrator. The economic implications of this potential reconfiguration of the US aircraft industry are discussed in the context of several techno-market futures, some of which look rather bleak for US workers in this industry.

  2. BOES: Building Occupancy Estimation System using sparse ambient vibration monitoring

    Science.gov (United States)

    Pan, Shijia; Bonde, Amelie; Jing, Jie; Zhang, Lin; Zhang, Pei; Noh, Hae Young

    2014-04-01

    In this paper, we present a room-level building occupancy estimation system (BOES) utilizing low-resolution vibration sensors that are sparsely distributed. Many ubiquitous computing and building maintenance systems require fine-grained occupancy knowledge to enable occupant centric services and optimize space and energy utilization. The sensing infrastructure support for current occupancy estimation systems often requires multiple intrusive sensors per room, resulting in systems that are both costly to deploy and difficult to maintain. To address these shortcomings, we developed BOES. BOES utilizes sparse vibration sensors to track occupancy levels and activities. Our system has three major components. 1) It extracts features that distinguish occupant activities from noise prone ambient vibrations and detects human footsteps. 2) Using a sequence of footsteps, the system localizes and tracks individuals by observing changes in the sequences. It uses this tracking information to identify when an occupant leaves or enters a room. 3) The entering and leaving room information are combined with detected individual location information to update the room-level occupancy state of the building. Through validation experiments in two different buildings, our system was able to achieve 99.55% accuracy for event detection, less than three feet average error for localization, and 85% accuracy in occupancy counting.

  3. Status of Advanced Stitched Unitized Composite Aircraft Structures

    Science.gov (United States)

    Jegley, Dawn C.; Velicki, Alex

    2013-01-01

    NASA has created the Environmentally Responsible Aviation (ERA) Project to explore and document the feasibility, benefits and technical risk of advanced vehicle configurations and enabling technologies that will reduce the impact of aviation on the environment. A critical aspect of this pursuit is the development of a lighter, more robust airframe that will enable the introduction of unconventional aircraft configurations that have higher lift-to-drag ratios, reduced drag, and lower community noise levels. The primary structural concept being developed under the ERA project in the Airframe Technology element is the Pultruded Rod Stitched Efficient Unitized Structure (PRSEUS) concept. This paper describes how researchers at NASA and The Boeing Company are working together to develop fundamental PRSEUS technologies that could someday be implemented on a transport size aircraft with high aspect ratio wings or unconventional shapes such as a hybrid wing body airplane design.

  4. Cisto gigante de colédoco Giant choledochal cyst

    Directory of Open Access Journals (Sweden)

    Olival Cirilo Lucena da Fonseca-Neto

    2007-12-01

    Full Text Available INTRODUÇÃO: A doença cística das vias biliares é anomalia congênita que pode acometer as vias biliares intra e/ou extra-hepáticas. A extra-hepática inclui os cistos de colédoco e a intra-hepática é conhecida por Doença de Caroli. Os cistos de colédoco de tamanho gigante são muito raros. OBJETIVO: Relatar o caso de um cisto de colédoco de tamanho gigante em uma paciente feminina. RELATO DE CASO: Mulher de 19 anos foi admitida com história de icterícia e acolia fecal há sete dias. Referia dor epigástrica associada com ingestão de dieta rica em gordura. Nos antecedentes pessoais relatou dois episódios de icterícia, aos 8 e 14 anos, que progrediram espontaneamente. No exame físico apresentava icterícia (+3/+4 e uma massa palpável indolor em mesogástrio foram os únicos achados. A ultrassonografia demonstrou grande formação cística de paredes finas adjacente ao hepatocolédoco, pâncreas e rim direito que media 18,5 x 10,2 cm. A colangioressonância confirmou o grande cisto de colédoco e hepatojejunoanastomose em "Y" de Roux após excisão do cisto e colecistectomia foi realizada. A formação cística media 20 x 15,5 x 12,5 cm e com um volume médio de 1000 mL. A paciente encontra-se em acompanhamento ambulatorial sem alterações hepatobiliares após o sétimo mês da operação. CONCLUSÃO: O cisto de colédoco deve fazer parte do diagnóstico diferencial em pacientes adultos jovens com icterícia e massa palpável; no entanto, a diferenciação entre ele e neoplasia maligna deve ser pesquisada.BACKGROUND: Choledochal cyst represents a rare congenital anomaly, eventually associated with intra and extrahepatic biliary tract disorders. Extrahepatic diseases include choledochal cysts and congenital dilation of the lower intrahepatic bile duct is known as Caroli's disease. Giant choledochal cyst constitutes a very rare abnormality. AIM:To report a giant choledochal cyst in a female patient. CASE REPORT: A 19-year

  5. The Influence of Human Factor in Aircraft Maintenance

    Directory of Open Access Journals (Sweden)

    Darko Virovac

    2017-06-01

    during aircraft maintenance. In the EASA approved aircraft maintenance organisation, which includes in its working system the human factor as well, the tendency is to apply the approach by continuous monitoring and analysis of errors in aircraft maintenance. Such approach achieves advance prevention or reduction of the occurrence of harmful events, such as accidents, incidents, injuries and in a wider sense damages related to aircraft operation and maintenance. The research presented in this paper is a result of gathering and systematization of errors caused by human factors over the last five years in one organisation for aircraft maintenance certified according to the European standards. The study encompasses an analysis of 28 (twenty-eight investigations of individual cases and provides insight into the main factors of errors. The results of analyses on the cause of occurrence of human error show similar results like the Boeing study which was carried out for the world fleet.

  6. Dryden B-52 Launch Aircraft in Flight over Dryden

    Science.gov (United States)

    1996-01-01

    parachute recovery systems used to recover the space shuttle solid rocket booster casings. It also supported eight orbiter (space shuttle) drag chute tests in 1990. In addition, the B-52 served as the air launch platform for the first six Pegasus space boosters. During its many years of service, the B-52 has undergone several modifications. The first major modification was made by North American Aviation (now part of Boeing) in support of the X-15 program. This involved creating a launch-panel-operator station for monitoring the status of the test vehicle being carried, cutting a large notch in the right inboard wing flap to accommodate the vertical tail of the X-15 aircraft, and installing a wing pylon that enables the B-52 to carry research vehicles and test articles to be air-launched/dropped. Located on the right wing, between the inboard engine pylon and the fuselage, this wing pylon was subjected to extensive testing prior to its use. For each test vehicle the B-52 carried, minor changes were made to the launch-panel operator's station. Built originally by the Boeing Company, the NASA B-52 is powered by eight Pratt & Whitney J57-19 turbojet engines, each of which produce 12,000 pounds of thrust. The aircraft's normal launch speed has been Mach 0.8 (about 530 miles per hour) and its normal drop altitude has been 40,000 to 45,000 feet. It is 156 feet long and has a wing span of 185 feet. The heaviest load it has carried was the No. 2 X-15 aircraft at 53,100 pounds. Project manager for the aircraft is Roy Bryant.

  7. The SOFIA Aircraft and its Modification

    Science.gov (United States)

    Kunz, Nans

    2002-01-01

    The primary focus of this paper is to describe the challenges involved in creating this highly modified aircraft that carries a twenty ton telescope to the Stratosphere and then loiters at this desired altitude to act as the observatory "dome" or platform. When the aircraft has reached its nominal cruise condition in the stratosphere of Mach 0.84, a large cavity door opens (the dome opens), exposing a large portion of the interior of the fuselage containing the telescope optics, directly to the Universe. The breadth of topics covered in this paper includes; the relevant criteria and the evaluation process that resulted in the selection of a Boeing 747-SP, the evolution of the design concept, a description of the structural modification including the analysis methods and tools, the aerodynamic issues associated with an open port cavity and how they were addressed, the aero-loads/disturbances imparted to the telescope and how they were measured in the wind tunnel and extrapolated to full size. For completeness, this paper also provides a brief overview of the SOFIA project including the joint project arrangement between NASA and DLR, a top level overview of the science objectives and the resulting requirements, and finally the current project status.

  8. Mutations in the COL1A1 and COL1A2 genes associated with osteogenesis imperfecta (OI) types I or III.

    Science.gov (United States)

    Augusciak-Duma, Aleksandra; Witecka, Joanna; Sieron, Aleksander L; Janeczko, Magdalena; Pietrzyk, Jacek J; Ochman, Karolina; Galicka, Anna; Borszewska-Kornacka, Maria K; Pilch, Jacek; Jakubowska-Pietkiewicz, Elzbieta

    2018-03-15

    Although over 85% of osteogenesis imperfecta (OI) cases are associated with mutations in the procollagen type I genes (COL1A1 or COL1A2), no hot spots for the mutations were associated with particular clinical phenotypes. Eight patients that were studied here, diagnosed with OI by clinical standards, are from the Polish population with no ethnic background indicated. Previously unpublished mutations were found in six out of those eight patients. Genotypes for polymorphisms (Sp1 - rs1800012 and PvuII - rs412777), linked to bone formation and metabolism were determined. Mutations were found in exons 2, 22, 50 and in introns 13 and 51 of the COL1A1 gene. In COL1A2, one mutation was identified in exon 22. Deletion type mutations in COL1A1 that resulted in OI type I had no effect on collagen type I secretion, nor on its intracellular accumulation. Also, a single base substitution in I13 (c.904-9 G>T) was associated with the OI type I. The OI type III was associated with a single base change in I51 of COL1A1, possibly causing an exon skipping. Also, a missense mutation in COL1A2 changing Gly→ Cys in the central part of the triple helical domain of the collagen type I molecule caused OI type III. It affected secretion of the heterotrimeric form of procollagen type I. However, no intracellular accumulation of procollagen chains could be detected. Mutation in COL1A2 affected its incorporation into procollagen type I. The results obtained shall help in genetic counseling of OI patients and provide a rational support for making informed, life important decisions by them and their families.

  9. Dryden B-52 Launch Aircraft on Edwards AFB Runway

    Science.gov (United States)

    1996-01-01

    booster casings. It also supported eight orbiter (space shuttle) drag chute tests in 1990. In addition, the B-52 served as the air launch platform for the first six Pegasus space boosters. During its many years of service, the B-52 has undergone several modifications. The first major modification was made by North American Aviation (now part of Boeing) in support of the X-15 program. This involved creating a launch-panel-operator station for monitoring the status of the test vehicle being carried, cutting a large notch in the right inboard wing flap to accommodate the vertical tail of the X-15 aircraft, and installing a wing pylon that enables the B-52 to carry research vehicles and test articles to be air-launched/dropped. Located on the right wing, between the inboard engine pylon and the fuselage, this wing pylon was subjected to extensive testing prior to its use. For each test vehicle the B-52 carried, minor changes were made to the launch-panel operator's station. Built originally by the Boeing Company, the NASA B-52 is powered by eight Pratt & Whitney J57-19 turbojet engines, each of which produce 12,000 pounds of thrust. The aircraft's normal launch speed has been Mach 0.8 (about 530 miles per hour) and its normal drop altitude has been 40,000 to 45,000 feet. It is 156 feet long and has a wing span of 185 feet. The heaviest load it has carried was the No. 2 X-15 aircraft at 53,100 pounds. Project manager for the aircraft is Roy Bryant.

  10. Dryden B-52 Launch Aircraft on Dryden Ramp

    Science.gov (United States)

    1996-01-01

    booster casings. It also supported eight orbiter (space shuttle) drag chute tests in 1990. In addition, the B-52 served as the air launch platform for the first six Pegasus space boosters. During its many years of service, the B-52 has undergone several modifications. The first major modification was made by North American Aviation (now part of Boeing) in support of the X-15 program. This involved creating a launch-panel-operator station for monitoring the status of the test vehicle being carried, cutting a large notch in the right inboard wing flap to accommodate the vertical tail of the X-15 aircraft, and installing a wing pylon that enables the B-52 to carry research vehicles and test articles to be air-launched/dropped. Located on the right wing, between the inboard engine pylon and the fuselage, this wing pylon was subjected to extensive testing prior to its use. For each test vehicle the B-52 carried, minor changes were made to the launch-panel operator's station. Built originally by the Boeing Company, the NASA B-52 is powered by eight Pratt & Whitney J57-19 turbojet engines, each of which produce 12,000 pounds of thrust. The aircraft's normal launch speed has been Mach 0.8 (about 530 miles per hour) and its normal drop altitude has been 40,000 to 45,000 feet. It is 156 feet long and has a wing span of 185 feet. The heaviest load it has carried was the No. 2 X-15 aircraft at 53,100 pounds. Project manager for the aircraft is Roy Bryant.

  11. EuroCirCol kick-off event

    CERN Multimedia

    Hardre, Julie

    2015-01-01

    The EuroCirCol (http://cern.ch/eurocircol) kick-off event at CERN on June 2-4 brought together 62 participants to constitute governance bodies, commit to the project plan and align the organisation, structures and processes of 16 institutions from 10 countries. The goal of the project is to conceive a post-LHC research infrastructure around a 100 km circular energy-frontier hadron collider capable of reaching 100 TeV collisions. The project officially started on June 1 and will run for four years. The total estimated budget of 11.2 million Euros includes a 2.99 million Euro contribution from the Horizon 2020 programme on developing new world-class research infrastructures (http://cordis.europa.eu/project/rcn/194962_en.html).

  12. Propulsion controlled aircraft computer

    Science.gov (United States)

    Cogan, Bruce R. (Inventor)

    2010-01-01

    A low-cost, easily retrofit Propulsion Controlled Aircraft (PCA) system for use on a wide range of commercial and military aircraft consists of an propulsion controlled aircraft computer that reads in aircraft data including aircraft state, pilot commands and other related data, calculates aircraft throttle position for a given maneuver commanded by the pilot, and then displays both current and calculated throttle position on a cockpit display to show the pilot where to move throttles to achieve the commanded maneuver, or is automatically sent digitally to command the engines directly.

  13. Entomopathogenic fungi in predatory beetles (Col: Carabidae and Staphylinidae) from agricultural fields

    DEFF Research Database (Denmark)

    Steenberg, T; Langer, V; Esbjerg, P

    1995-01-01

    Prevalence of entomopathogenic fungi was studied in overwintering ground beetles (Col.: Carabidae) and rove beetles (Col.: Staphylinidae) collected from fields of lucerne, white cabbage and white cabbage undersown with white clover. In general infection levels in adult ground beetles and rove bee...

  14. A genetic variant in COL11A1 is functionally associated with lumbar ...

    Indian Academy of Sciences (India)

    This study aimed to explore whether the genetic variant of COL11A1 is functionally associated with the development of lumbar disc herniation (LDH) in Chinese population. SNP rs1676486 of COL11A1 was genotyped in 647 patients and 532 healthy controls. The differences of genotype and allele distributions between ...

  15. Novel COL4A1 mutations cause cerebral small vessel disease by haploinsufficiency

    NARCIS (Netherlands)

    Lemmens, R.; Maugeri, A.; Niessen, H.W.M.; Goris, A.; Tousseyn, T.; Demaerel, P.; Corveleyn, A.; Robberecht, W.; van der Knaap, M.S.; Thijs, V.N.; Zwijnenburg, P.J.G.

    2013-01-01

    Mutations in COL4A1 have been identified in families with hereditary small vessel disease of the brain presumably due to a dominant-negative mechanism. Here, we report on two novel mutations in COL4A1 in two families with porencephaly, intracerebral hemorrhage and severe white matter disease caused

  16. A genetic variant in COL11A1 is functionally associated with lumbar ...

    Indian Academy of Sciences (India)

    WENJUN LIU

    2017-12-14

    Dec 14, 2017 ... Abstract. This study aimed to explore whether the genetic variant of COL11A1 is functionally associated with the development of lumbar disc herniation (LDH) in Chinese population. SNP rs1676486 of COL11A1 was genotyped in 647 patients and 532 healthy controls. The differences of genotype and ...

  17. Database on aircraft accidents

    International Nuclear Information System (INIS)

    Nishio, Masahide; Koriyama, Tamio

    2013-11-01

    The Reactor Safety Subcommittee in the Nuclear Safety and Preservation Committee published 'The criteria on assessment of probability of aircraft crash into light water reactor facilities' as the standard method for evaluating probability of aircraft crash into nuclear reactor facilities in July 2002. In response to this issue, Japan Nuclear Energy Safety Organization has been collecting open information on aircraft accidents of commercial airplanes, self-defense force (SDF) airplanes and US force airplanes every year since 2003, sorting out them and developing the database of aircraft accidents for the latest 20 years to evaluate probability of aircraft crash into nuclear reactor facilities. In this report the database was revised by adding aircraft accidents in 2011 to the existing database and deleting aircraft accidents in 1991 from it, resulting in development of the revised 2012 database for the latest 20 years from 1992 to 2011. Furthermore, the flight information on commercial aircrafts was also collected to develop the flight database for the latest 20 years from 1992 to 2011 to evaluate probability of aircraft crash into reactor facilities. The method for developing the database of aircraft accidents to evaluate probability of aircraft crash into reactor facilities is based on the report 'The criteria on assessment of probability of aircraft crash into light water reactor facilities' described above. The 2012 revised database for the latest 20 years from 1992 to 2011 shows the followings. The trend of the 2012 database changes little as compared to the last year's report. (1) The data of commercial aircraft accidents is based on 'Aircraft accident investigation reports of Japan transport safety board' of Ministry of Land, Infrastructure, Transport and Tourism. The number of commercial aircraft accidents is 4 for large fixed-wing aircraft, 58 for small fixed-wing aircraft, 5 for large bladed aircraft and 99 for small bladed aircraft. The relevant accidents

  18. The BOEING double subharmonic electron injector - performance measurements

    International Nuclear Information System (INIS)

    Adamski, J.L.; Gallagher, W.J.; Kennedy, R.C.; Stoffstall, D.R.; Tyson, E.L.; Yeremian, A.D.

    1985-01-01

    A two stage subharmonic injector has been installed and tested on the Boeing S band linac. The injector is designed as a prototype front end for a high voltage linac for free electron laser research. This accelerator will require long macropulse trains of widely spaced high current micropulses. Single micropulse output beams of 1-2 nC, 10 ps width, 1% full width energy spread and normalized emittance of epsilon /SUB n/ = βγπr/phi/ = 0.01 cm-rad have been measured. The data are in good agreement with model predictions

  19. Boeing Low-Thrust Geosynchronous Transfer Mission Experience

    Science.gov (United States)

    Poole, Mark; Ho, Monte

    2007-01-01

    Since 2000, Boeing 702 satellites have used electric propulsion for transfer to geostationary orbits. The use of the 25cm Xenon Ion Propulsion System (25cm XIPS) results in more than a tenfold increase in specific impulse with the corresponding decrease in propellant mass needed to complete the mission when compared to chemical propulsion[1]. In addition to more favorable mass properties, with the use of XIPS, the 702 has been able to achieve orbit insertions with higher accuracy than it would have been possible with the use of chemical thrusters. This paper describes the experience attained by using the 702 XIPS ascent strategy to transfer satellite to geosynchronous orbits.

  20. STS-65 crewmembers participate in bench review at Boeing Building

    Science.gov (United States)

    1994-01-01

    Attired in clean suits, STS-65 Payload Commander (PLC) Richard J. Hieb (left) and Payload Specialist Chiaki Mukai examine the contents of a stowage locker during a bench review at Boeing's Flight Equipment Processing Facility (FEPF) near the Johnson Space Center (JSC). In the background, Commander Robert D. Cabana inspects additional equipment to be carried aboard the Space Shuttle Columbia, Orbiter Vehicle (OV) 102, for the scheduled July flight of the second International Microgravity Laboratory (IML-2) mission. Mukai represents Japan's National Space Development Agency (NASDA). Photo taken by NASA JSC contract photographer Scott A. Wickes.

  1. Subsonic Ultra Green Aircraft Research. Phase II - Volume I; Truss Braced Wing Design Exploration

    Science.gov (United States)

    Bradley, Marty K.; Droney, Christopher K.; Allen, Timothy J.

    2015-01-01

    This report summarizes the Truss Braced Wing (TBW) work accomplished by the Boeing Subsonic Ultra Green Aircraft Research (SUGAR) team, consisting of Boeing Research and Technology, Boeing Commercial Airplanes, General Electric, Georgia Tech, Virginia Tech, NextGen Aeronautics, and Microcraft. A multi-disciplinary optimization (MDO) environment defined the geometry that was further refined for the updated SUGAR High TBW configuration. Airfoil shapes were tested in the NASA TCT facility, and an aeroelastic model was tested in the NASA TDT facility. Flutter suppression was successfully demonstrated using control laws derived from test system ID data and analysis models. Aeroelastic impacts for the TBW design are manageable and smaller than assumed in Phase I. Flutter analysis of TBW designs need to include pre-load and large displacement non-linear effects to obtain a reasonable match to test data. With the updated performance and sizing, fuel burn and energy use is reduced by 54% compared to the SUGAR Free current technology Baseline (Goal 60%). Use of the unducted fan version of the engine reduces fuel burn and energy by 56% compared to the Baseline. Technology development roadmaps were updated, and an airport compatibility analysis established feasibility of a folding wing aircraft at existing airports.

  2. Subsonic Ultra Green Aircraft Research: Phase 2. Volume 2; Hybrid Electric Design Exploration

    Science.gov (United States)

    Bradley, Marty K.; Droney, Christopher K.

    2015-01-01

    This report summarizes the hybrid electric concept design, analysis, and modeling work accomplished by the Boeing Subsonic Ultra Green Aircraft Research (SUGAR) team, consisting of Boeing Research and Technology, Boeing Commercial Airplanes, General Electric, and Georgia Tech.Performance and sizing tasks were conducted for hybrid electric versions of a conventional tube-and-wing aircraft and a hybrid wing body. The high wing Truss Braced Wing (TBW) SUGAR Volt was updated based on results from the TBW work (documented separately) and new engine performance models. Energy cost and acoustic analyses were conducted and technology roadmaps were updated for hybrid electric and battery technology. NOx emissions were calculated for landing and takeoff (LTO) and cruise. NPSS models were developed for hybrid electric components and tested using an integrated analysis of superconducting and non-superconducting hybrid electric engines. The hybrid electric SUGAR Volt was shown to produce significant emissions and fuel burn reductions beyond those achieved by the conventionally powered SUGAR High and was able to meet the NASA goals for fuel burn. Total energy utilization was not decreased but reduced energy cost can be achieved for some scenarios. The team was not able to identify a technology development path to meet NASA's noise goals

  3. Homebuilt aircraft crashes.

    Science.gov (United States)

    Hasselquist, A; Baker, S P

    1999-06-01

    While the number of general aviation crashes has decreased over the 5 yr prior to 1993, the total number of homebuilt aircraft crashes has increased by nearly 25%. Research was undertaken to analyze these crashes and identify causal factors or unique problems associated with homebuilt aircraft. Some 200 National Transportation Safety Board computer records and two-page descriptive briefs were analyzed for homebuilt aircraft crashes during 1993. Using descriptive epidemiology, variables were looked at in detail and comparisons were made with general aviation crashes during the-same year. Despite accounting for only 3% of all hours flown in general aviation certified aircraft for 1993, homebuilt aircraft accounted for 10% of the crashes and experienced a higher fatal crash rate. Crashes due to mechanical failure and crashes on takeoff and climb were more common in homebuilt aircraft as compared with general aviation. Other significant causal factors for homebuilt aircraft crashes included: minimal flight time in type specific aircraft, improper maintenance and improper design or assembly. Greater emphasis needs to be placed on educating homebuilt aircraft owners in the importance of following Federal Aviation Administration guidelines for certification and air worthiness testing. Understanding the aircraft's specifications and design limitations prior to the initial flight and properly maintaining the aircraft should also help to reverse the trend in the number of these crashes and subsequent lives lost. A system for assuring that all home-built aircraft are certified and more accurate reporting of flight hours are needed for accurate tracking of homebuilt aircraft crash rates.

  4. Database on aircraft accidents

    International Nuclear Information System (INIS)

    Nishio, Masahide; Koriyama, Tamio

    2012-09-01

    The Reactor Safety Subcommittee in the Nuclear Safety and Preservation Committee published the report 'The criteria on assessment of probability of aircraft crash into light water reactor facilities' as the standard method for evaluating probability of aircraft crash into nuclear reactor facilities in July 2002. In response to the report, Japan Nuclear Energy Safety Organization has been collecting open information on aircraft accidents of commercial airplanes, self-defense force (SDF) airplanes and US force airplanes every year since 2003, sorting out them and developing the database of aircraft accidents for latest 20 years to evaluate probability of aircraft crash into nuclear reactor facilities. This year, the database was revised by adding aircraft accidents in 2010 to the existing database and deleting aircraft accidents in 1991 from it, resulting in development of the revised 2011 database for latest 20 years from 1991 to 2010. Furthermore, the flight information on commercial aircrafts was also collected to develop the flight database for latest 20 years from 1991 to 2010 to evaluate probability of aircraft crash into reactor facilities. The method for developing the database of aircraft accidents to evaluate probability of aircraft crash into reactor facilities is based on the report 'The criteria on assessment of probability of aircraft crash into light water reactor facilities' described above. The 2011 revised database for latest 20 years from 1991 to 2010 shows the followings. The trend of the 2011 database changes little as compared to the last year's one. (1) The data of commercial aircraft accidents is based on 'Aircraft accident investigation reports of Japan transport safety board' of Ministry of Land, Infrastructure, Transport and Tourism. 4 large fixed-wing aircraft accidents, 58 small fixed-wing aircraft accidents, 5 large bladed aircraft accidents and 114 small bladed aircraft accidents occurred. The relevant accidents for evaluating

  5. Screening of the COL2A1 mutation in idiopathic osteonecrosis of the femoral head.

    Science.gov (United States)

    Sakamoto, Yuma; Yamamoto, Takuaki; Miyake, Noriko; Matsumoto, Naomichi; Iida, Aritoshi; Nakashima, Yasuharu; Iwamoto, Yukihide; Ikegawa, Shiro

    2017-04-01

    Idiopathic osteonecrosis of the femoral head (idiopathic ONFH) is an ischemic disorder resulting in necrosis of the subchondral bone of the femoral head. COL2A1 mutations, including c.3508G>A, have been reported to be involved in its etiology. However, the etiological role of COL2A1 mutations in idiopathic ONFH remains controversial, because the pathology of idiopathic ONFH is ischemic necrosis, not epiphyseal dysplasia usually seen in the diseases caused by COL2A1 mutations. The purpose of this study is to examine whether COL2A1 mutations have causal relation with idiopathic ONFH or not. We recruited 1,451 Japanese patients with idiopathic ONFH, including steroid-, alcohol-, and neither steroid nor alcohol-associated (neither-associated) ONFH. The diagnosis was based on the criteria of the Japanese Research Committee on idiopathic ONFH of the Ministry of Health, Labour and Welfare. By whole-exome sequencing, entire COL2A1 coding regions and flanking introns were analyzed in 49 neither-associated ONFH patients. In addition, the c.3508G>A mutation of COL2A1 was checked in all idiopathic ONFH patients using the invader assay. Whole-exome sequencing did not detect any COL2A1 mutations in the 49 patients. The c.3508G>A mutation was not found in any of the 1,451 patients. In conclusion, COL2A1 is unlikely to cause idiopathic ONFH. Epiphyseal dysplasia of the femoral head caused by COL2A1 mutations may radiographically mimic idiopathic ONFH. COL2A1 mutations should prompt clinical re-evaluation of the patient's phenotype. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:768-774, 2017. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

  6. Aircraft Survivability. Spring 2011

    Science.gov (United States)

    2011-01-01

    panel exhibiting telltale signs and critical fragments were identified and collected. The weapon employed against the aircraft was correctly assessed...701C engines (for FCR- equipped Apache Longbows), and a fully integrated cockpit. In addition, the aircraft received improved survivability...sustained analytical contributions to improve the survivability and effectiveness of US military aircraft and weapon systems. These contributions

  7. NASA Boeing 757 HIRF test series low power on-the-ground tests

    Energy Technology Data Exchange (ETDEWEB)

    Poggio, A.J.; Pennock, S.T.; Zacharias, R.A.; Avalle, C.A.; Carney, H.L. [National Aeronautics and Space Administration, Langley AFB, VA (United States). Langley Research Center

    1996-08-01

    The data acquisition phase of a program intended to provide data for the validation of computational, analytical, and experimental techniques for the assessment of electromagnetic effects in commercial transports; for the checkout of instrumentation for following test programs; and for the support of protection engineering of airborne systems has been completed. Funded by the NASA Fly-By-Light/ Power-By-Wire Program, the initial phase involved on-the-ground electromagnetic measurements using the NASA Boeing 757 and was executed in the LESLI Facility at the USAF Phillips Laboratory. The major participants in this project were LLNL, NASA Langley Research Center, Phillips Laboratory, and UIE, Inc. The tests were performed over a five week period during September through November, 1994. Measurements were made of the fields coupled into the aircraft interior and signals induced in select structures and equipment under controlled illumination by RF fields. A characterization of the ground was also performed to permit ground effects to be included in forthcoming validation exercises. This report and the associated test plan that is included as an appendix represent a definition of the overall on-the-ground test program. They include descriptions of the test rationale, test layout, and samples of the data. In this report, a detailed description of each executed test is provided, as is the data identification (data id) relating the specific test with its relevant data files. Samples of some inferences from the data that will be useful in protection engineering and EM effects mitigation are also presented. The test plan which guided the execution of the tests, a test report by UIE Inc., and the report describing the concrete pad characterization are included as appendices.

  8. Fetal origin of brain damage in 2 infants with a COL4A1 mutation: fetal and neonatal MRI

    NARCIS (Netherlands)

    Vermeulen, R. J.; Peeters-Scholte, C.; van Vugt, J. J. M.; van Vught, J. J. M. G.; Barkhof, F.; Rizzu, P.; van der Schoor, S. R. D.; van der Knaap, M. S.

    2011-01-01

    Mutations in the gene COL4A1, encoding collagen IV A1, are associated with familial porencephaly. Previously, COL4A1 mutation-associated antenatal hemorrhages have been suggested by early post-natal imaging. We describe 2 children with fetal intracerebral hemorrhages and a COL4A1 mutation. There was

  9. Novel COL4A1 mutations cause cerebral small vessel disease by haploinsufficiency.

    Science.gov (United States)

    Lemmens, Robin; Maugeri, Alessandra; Niessen, Hans W M; Goris, An; Tousseyn, Thomas; Demaerel, Philippe; Corveleyn, Anniek; Robberecht, Wim; van der Knaap, Marjo S; Thijs, Vincent N; Zwijnenburg, Petra J G

    2013-01-15

    Mutations in COL4A1 have been identified in families with hereditary small vessel disease of the brain presumably due to a dominant-negative mechanism. Here, we report on two novel mutations in COL4A1 in two families with porencephaly, intracerebral hemorrhage and severe white matter disease caused by haploinsufficiency. Two families with various clinical presentations of cerebral microangiopathy and autosomal dominant inheritance were examined. Clinical, neuroradiological and genetic investigations were performed. Electron microscopy of the skin was also performed. In one of the families, sequence analysis revealed a one base deletion, c.2085del, leading to a frameshift and a premature stopcodon, p.(Gly696fs). In the other family, a splice site mutation was identified, c.2194-1G>A, which most likely leads to skipping of an exon with a frameshift and premature termination as a result. In fibroblasts of affected individuals from both the families, nonsense-mediated decay (NMD) of the mutant COL4A1 messenger RNAs (mRNAs) and a clear reduction of COL4A1 protein expression were demonstrated, indicating haploinsufficiency of COL4A1. Moreover, thickening of the capillary basement membrane in the skin was documented, similar to reports in patients with COL4A1 missense mutations. These findings suggest haploinsufficiency, a different mechanism from the commonly assumed dominant-negative effect, for COL4A1 mutations as a cause of (antenatal) intracerebral hemorrhage and white matter disease.

  10. The NASA Dryden 747 Shuttle Carrier Aircraft crew poses in an engine inlet

    Science.gov (United States)

    2000-01-01

    The NASA Dryden 747 Shuttle Carrier Aircraft crew poses in an engine inlet; Standing L to R - aircraft mechanic John Goleno and SCA Team Leader Pete Seidl; Kneeling L to R - aircraft mechanics Todd Weston and Arvid Knutson, and avionics technician Jim Bedard NASA uses two modified Boeing 747 jetliners, originally manufactured for commercial use, as Space Shuttle Carrier Aircraft (SCA). One is a 747-100 model, while the other is designated a 747-100SR (short range). The two aircraft are identical in appearance and in their performance as Shuttle Carrier Aircraft. The 747 series of aircraft are four-engine intercontinental-range swept-wing 'jumbo jets' that entered commercial service in 1969. The SCAs are used to ferry space shuttle orbiters from landing sites back to the launch complex at the Kennedy Space Center, and also to and from other locations too distant for the orbiters to be delivered by ground transportation. The orbiters are placed atop the SCAs by Mate-Demate Devices, large gantry-like structures which hoist the orbiters off the ground for post-flight servicing, and then mate them with the SCAs for ferry flights.

  11. Auralization of Hybrid Wing Body Aircraft Flyover Noise from System Noise Predictions

    Science.gov (United States)

    Rizzi, Stephen A.; Aumann, Aric R.; Lopes, Leonvard V.; Burley, Casey L.

    2013-01-01

    System noise assessments of a state-of-the-art reference aircraft (similar to a Boeing 777-200ER with GE90-like turbofan engines) and several hybrid wing body (HWB) aircraft configurations were recently performed using NASA engine and aircraft system analysis tools. The HWB aircraft were sized to an equivalent mission as the reference aircraft and assessments were performed using measurements of airframe shielding from a series of propulsion airframe aeroacoustic experiments. The focus of this work is to auralize flyover noise from the reference aircraft and the best HWB configuration using source noise predictions and shielding data based largely on the earlier assessments. For each aircraft, three flyover conditions are auralized. These correspond to approach, sideline, and cutback operating states, but flown in straight and level flight trajectories. The auralizations are performed using synthesis and simulation tools developed at NASA. Audio and visual presentations are provided to allow the reader to experience the flyover from the perspective of a listener in the simulated environment.

  12. 77 FR 54798 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-09-06

    ... NPRM (76 FR 62667, October 11, 2011): Conflict With Aircraft Maintenance Manual (AMM) UPS also stated..., October 11, 2011) would put the UPS mechanics in an untenable situation. Mechanics following AMM...

  13. Collimation and material science studies (ColMat) at GSI.

    CERN Document Server

    Stadlmann, J; Kollmus, H; Krause, M; Mustafin, E; Petzenhauser, I; Spiller, P; Strasik, I; Tahir, N; Tomut, M; Trautmann, C

    2010-01-01

    Within the frame of the EuCARD program, the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt is performing accelerator R&D in workpackage 8: ColMat. The coordinated effort is focussed on materials aspects important for building the FAIR accelerator facility at GSI and the LHC upgrade at CERN. Accelerator components and especially protection devices have to be operated in high dose environments. The radiation hazard occurs either by the primary proton and ion beams or the secondary radiation after initial beam loss. Detailed numerical simulations have been carried out to study the damage caused to solid targets by the full impact of the LHC beam as well as the SPS beam. Tungsten, copper and graphite as possible collimator materials have been studied. Experimental an theoretical studies on radiation damage on materials used for the LHC upgrade and the FAIR accelerators are performed at the present GSI experimental facilities. Technical decisions based on these results will have an impact on the F...

  14. Boeing Delta II rocket for FUSE launch arrives at CCAS

    Science.gov (United States)

    1999-01-01

    At Launch Pad 17A, Cape Canaveral Air Station (CCAS), the first stage of a Boeing Delta II rocket is raised for its journey up the launch tower. The rocket is targeted to launch NASA's Far Ultraviolet Spectroscopic Explorer (FUSE), developed by The Johns Hopkins University under contract to Goddard Space Flight Center, Greenbelt, Md. FUSE will investigate the origin and evolution of the lightest elements in the universe, hydrogen and deuterium. In addition, the FUSE satellite will examine the forces and process involved in the evolution of the galaxies, stars and planetary systems by investigating light in the far ultraviolet portion of the electromagnetic spectrum. FUSE is scheduled to be launched June 23 at CCAS.

  15. Potential for Sonic Boom Reduction of the Boeing HSCT

    Science.gov (United States)

    Haglund, George T.

    1999-01-01

    The HSR sonic boom technology program includes a goal of reducing the objectionable aspects of sonic boom. Earlier HSCT sonic boom studies considered achieving significant sonic boom reduction by the use of arrow-wing planforms and detailed shaping of the airplane to produce shaped waveforms (non N-waves) at the ground. While these design efforts were largely successful, the added risk and cost of the airplanes were judged to be unacceptable. The objective of the current work is to explore smaller configuration refinements that could lead to reduced sonic boom impact, within design and operational constraints. A somewhat modest target of 10% reduction in sonic boom maximum overpressure was selected to minimize the effect on the configuration performance. This work was a joint NASA/Industry effort, utilizing the respective strengths of team members at Boeing, NASA Langley, and NASA Ames. The approach used was to first explore a wide range of modifications and airplane characteristics for their effects on sonic boom and drag, using classical Modified Linear Theory (MLT) methods. CFD methods were then used to verify promising, modifications and to analyze modifications for which the MLT methods were not appropriate. The tea m produced a list of configuration changes with their effects on sonic boom and, in some cases, an estimate of the drag penalty. The most promising modifications were applied to produce a boom-softened derivative of the baseline Boeing High Speed Civil Transport (HSCT) configuration. This boom-softened configuration was analyzed in detail for the reduce sonic boom impact and also for the effect of the configuration modifications on drag, weight, and overall performance relative to the baseline.

  16. The ColM Family, Polymorphic Toxins Breaching the Bacterial Cell Wall

    Directory of Open Access Journals (Sweden)

    Maarten G. K. Ghequire

    2018-02-01

    Full Text Available Bacteria host an arsenal of antagonism-mediating molecules to combat for ecologic space. Bacteriocins represent a pivotal group of secreted antibacterial peptides and proteins assisting in this fight, mainly eliminating relatives. Colicin M, a model for peptidoglycan-interfering bacteriocins in Gram-negative bacteria, appears to be part of a set of polymorphic toxins equipped with such a catalytic domain (ColM targeting lipid II. Diversifying recombination has enabled parasitism of different receptors and has also given rise to hybrid bacteriocins in which ColM is associated with another toxin module. Remarkably, ColM toxins have recruited a diverse array of immunity partners, comprising cytoplasmic membrane-associated proteins with different topologies. Together, these findings suggest that different immunity mechanisms have evolved for ColM, in contrast to bacteriocins with nuclease activities.

  17. Is the COL5A1 rs12722 gene polymorphism associated with running economy?

    Directory of Open Access Journals (Sweden)

    Rômulo Bertuzzi

    Full Text Available The COL5A1 rs12722 polymorphism is considered to be a novel genetic marker for endurance running performance. It has been postulated that COL5A1 rs12722 may influence the elasticity of tendons and the energetic cost of running. To date, there are no experimental data in the literature supporting the relationship between range of motion, running economy, and the COL5A1 rs12722 gene polymorphism. Therefore, the main purpose of the current study was to analyze the influence of the COL5A1rs12722 polymorphism on running economy and range of motion. One hundred and fifty (n = 150 physically active young men performed the following tests: a a maximal incremental treadmill test, b two constant-speed running tests (10 km · h(-1 and 12 km · h(-1 to determine the running economy, and c a sit-and-reach test to determine the range of motion. All of the subjects were genotyped for the COL5A1 rs12722 single-nucleotide polymorphism. The genotype frequencies were TT = 27.9%, CT = 55.8%, and CC = 16.3%. There were no significant differences between COL5A1 genotypes for running economy measured at 10 km · h(-1 (p = 0.232 and 12 km · h(-1 (p = 0.259. Similarly, there were no significant differences between COL5A1 genotypes for range of motion (p = 0.337. These findings suggest that the previous relationship reported between COL5A1 rs12722 genotypes and running endurance performance might not be mediated by the energetic cost of running.

  18. Is the COL5A1 rs12722 Gene Polymorphism Associated with Running Economy?

    Science.gov (United States)

    Bertuzzi, Rômulo; Pasqua, Leonardo A.; Bueno, Salomão; Lima-Silva, Adriano Eduardo; Matsuda, Monique; Marquezini, Monica; Saldiva, Paulo H.

    2014-01-01

    The COL5A1 rs12722 polymorphism is considered to be a novel genetic marker for endurance running performance. It has been postulated that COL5A1 rs12722 may influence the elasticity of tendons and the energetic cost of running. To date, there are no experimental data in the literature supporting the relationship between range of motion, running economy, and the COL5A1 rs12722 gene polymorphism. Therefore, the main purpose of the current study was to analyze the influence of the COL5A1rs12722 polymorphism on running economy and range of motion. One hundred and fifty (n = 150) physically active young men performed the following tests: a) a maximal incremental treadmill test, b) two constant-speed running tests (10 km•h−1 and 12 km•h−1) to determine the running economy, and c) a sit-and-reach test to determine the range of motion. All of the subjects were genotyped for the COL5A1 rs12722 single-nucleotide polymorphism. The genotype frequencies were TT = 27.9%, CT = 55.8%, and CC = 16.3%. There were no significant differences between COL5A1 genotypes for running economy measured at 10 km•h−1 (p = 0.232) and 12 km•h−1 (p = 0.259). Similarly, there were no significant differences between COL5A1 genotypes for range of motion (p = 0.337). These findings suggest that the previous relationship reported between COL5A1 rs12722 genotypes and running endurance performance might not be mediated by the energetic cost of running. PMID:25188268

  19. 75 FR 27662 - Special Conditions: Boeing 747-468, Installation of a Medical Lift

    Science.gov (United States)

    2010-05-18

    ... substantive public contact with FAA personnel concerning these special conditions. You can inspect the docket... Boeing on December 22, 1988. 8. Special Condition No. 25-ANM-25, which established lightning-and radio...

  20. Neural Network Autopilot System for a Mathematical Model of the Boeing 747

    National Research Council Canada - National Science Library

    Cottrill, Gerald

    1998-01-01

    .... Five on-line learning neural network autopilot systems, trained with the Standard and Extended Back-Progagation algorithms, were applied to a six degree-of-freedom non-linear simulation of a Boeing 747-200...

  1. Estonian Airi Boeing sattus kaks korda hädaolukorda / Krister Kivi

    Index Scriptorium Estoniae

    Kivi, Krister, 1975-

    2011-01-01

    Estonian Airi Boeing ES-ABL sattus 2011. aasta algus kahel korral ohtlikku olukorda. Lennuamet tegi Estonian Airile ettekirjutuse, kuid seda pole ameti kodulehel avaldatud. Lennufirma kapteni ja lennuohutuse inspektori Andreas Kari, lennuameti selgitusi

  2. Vaporized Hydrogen Peroxide (VHP) Decontamination of a Section of a Boeing 747 Cabin

    National Research Council Canada - National Science Library

    Shaffstall, Robert M; Garner, Robert P; Bishop, Joshua; Cameron-Landis, Lora; Eddington, Donald L; Hau, Gwen; Spera, Shawn; Mielnik, Thaddeus; Thomas, James A

    2006-01-01

    ... (an FAA-owned Boeing 747). When exposed to an appropriate concentration of VHP vapor in the cabin test section, biological indicators inoculated with 106 colony forming units of Geobacillus stearothermophilus spores...

  3. ATM Technology Demonstration-1 Phase II Boeing Configurable Graphical Display (CGD) Software Design Description

    Science.gov (United States)

    Wilber, George F.

    2017-01-01

    This Software Description Document (SDD) captures the design for developing the Flight Interval Management (FIM) system Configurable Graphics Display (CGD) software. Specifically this SDD describes aspects of the Boeing CGD software and the surrounding context and interfaces. It does not describe the Honeywell components of the CGD system. The SDD provides the system overview, architectural design, and detailed design with all the necessary information to implement the Boeing components of the CGD software and integrate them into the CGD subsystem within the larger FIM system. Overall system and CGD system-level requirements are derived from the CGD SRS (in turn derived from the Boeing System Requirements Design Document (SRDD)). Display and look-and-feel requirements are derived from Human Machine Interface (HMI) design documents and working group recommendations. This Boeing CGD SDD is required to support the upcoming Critical Design Review (CDR).

  4. Inerting a Boeing 747SP Center Wing Tank Scale Model With Nitrogen-Enriched Air

    National Research Council Canada - National Science Library

    Cavage, William

    2002-01-01

    Tests were performed in a 0.24 scale model of a Boeing 747SP center wing tank to validate the existing assumptions for inerting complex geometric spaces, which were developed from previous experiments, and to facilitate design...

  5. Raptors and aircraft

    Science.gov (United States)

    Smith, D.G.; Ellis, D.H.; Johnson, T.H.; Glinski, Richard L.; Pendleton, Beth Giron; Moss, Mary Beth; LeFranc, Maurice N.=; Millsap, Brian A.; Hoffman, Stephen W.

    1988-01-01

    Less than 5% of all bird strikes of aircraft are by raptor species, but damage to airframe structure or jet engine dysfunction are likely consequences. Beneficial aircraft-raptor interactions include the use of raptor species to frighten unwanted birds from airport areas and the use of aircraft to census raptor species. Many interactions, however, modify the raptor?s immediate behavior and some may decrease reproduction of sensitive species. Raptors may respond to aircraft stimuli by exhibiting alarm, increased heart rate, flushing or fleeing and occasionally by directly attacking intruding aircraft. To date, most studies reveal that raptor responses to aircraft are brief and do not limit reproduction; however, additional study is needed.

  6. Luftfahrtindustrie: Implikationen der WTO-Berufungsentscheidungen für Airbus und Boeing

    OpenAIRE

    Wittig, Stephan

    2012-01-01

    In dem seit mehr als sieben Jahren andauernden Handelsstreit zwischen der EU und den USA über Subventionen für die Flugzeughersteller Airbus und Boeing hat die Berufungsinstanz der Welthandelsorganisation, der WTO-Appellate Body, am 12. März 2012 ihren Abschlussbericht über US-amerikanische Subventionen für Boeing veröffentlicht. Stephan Wittig, University of Cambridge, analysiert die Entscheidung.

  7. Sulfuric Acid and Soot Particles in Aircraft Exhaust

    Science.gov (United States)

    Pueschel, Rudolf F.; Verma, S.; Ferry, G. V.; Goodman, J.; Strawa, A. W.; Gore, Warren J. Y. (Technical Monitor)

    1997-01-01

    Aircraft have become the fastest, fairly convenient and, in most cases of long-distance travel, most economical mode of travel. This is reflected in the increase of commercial air traffic at a rate of 6% per year since 1978. Future annual growth rates of passenger miles of 4% for domestic and 6% for international routes are projected. A still larger annual increase of 8.5% is expected for the Asia/Pacific region. To meet that growth, Boeing predicts the addition of 15,900 new aircraft to the world's fleets, valued at more than $1.1 trillion, within the next 20 years. The largest concern of environmental consequences of aircraft emissions deals with ozone (O3), because: (1) the O3 layer protects the blaspheme from short-ultraviolet radiation that can cause damage to human, animal and plant life, and possibly affect agricultural production and the marine food chain; (2) O3 is important for the production of the hydroxyl radical (OH) which, in turn, is responsible for the destruction of other greenhouse gases, e.g., methane (CH4) and for the removal of other pollutants, and (3) O3 is a greenhouse gas. Additional information is contained in the original extended abstract.

  8. Sulfuric Acid and Soot Particle Formation in Aircraft Exhaust

    Science.gov (United States)

    Pueschel, Rudolf F.; Verma, S.; Ferry, G. V.; Howard, S. D.; Vay, S.; Kinne, S. A.; Baumgardner, D.; Dermott, P.; Kreidenweis, S.; Goodman, J.; hide

    1997-01-01

    A combination of CN counts, Ames wire impactor size analyses and optical particle counter data in aircraft exhaust results in a continuous particle size distribution between 0.01 micrometer and 1 micrometer particle radius sampled in the exhaust of a Boeing 757 research aircraft. The two orders of magnitude size range covered by the measurements correspond to 6-7 orders of magnitude particle concentration. CN counts and small particle wire impactor data determine a nucleation mode, composed of aircraft-emitted sulfuric acid aerosol, that contributes between 62% and 85% to the total aerosol surface area and between 31% and 34% to its volume. Soot aerosol comprises 0.5% of the surface area of the sulfuric acid aerosol. Emission indices are: EIH2SO4 = 0.05 g/kgFUEL and (0.2-0.5) g/kgFUEL (for 75 ppmm and 675 ppmm fuel-S, respectively), 2.5E4sulfur (gas) to H2SO4 (particle) conversion efficiency is between 10% and 25%.

  9. Numerical modeling of interaction of the aircraft engine with concrete protective structures

    Science.gov (United States)

    Radchenko, P. A.; Batuev, S. P.; Radchenko, A. V.; Plevkov, V. S.

    2018-01-01

    The paper presents numerical modeling results considering interaction of Boeing 747 aircraft engine with nuclear power station protective shell. Protective shell has been given as a reinforced concrete structure with complex scheme of reinforcement. The engine has been simulated by cylinder projectile made from titanium alloy. The interaction velocity has comprised 180 m/s. The simulation is three-dimensional solved by finite element method using the author’s own software package EFES. Fracture and fragmentation of materials have been considered in calculations. Program software has been assessed to be used in calculation of multiple-contact objectives.

  10. Development and validation of bonded composite doubler repairs for commercial aircraft.

    Energy Technology Data Exchange (ETDEWEB)

    Roach, Dennis Patrick; Rackow, Kirk A.

    2007-07-01

    A typical aircraft can experience over 2,000 fatigue cycles (cabin pressurizations) and even greater flight hours in a single year. An unavoidable by-product of aircraft use is that crack, impact, and corrosion flaws develop throughout the aircraft's skin and substructure elements. Economic barriers to the purchase of new aircraft have placed even greater demands on efficient and safe repair methods. The use of bonded composite doublers offers the airframe manufacturers and aircraft maintenance facilities a cost effective method to safely extend the lives of their aircraft. Instead of riveting multiple steel or aluminum plates to facilitate an aircraft repair, it is now possible to bond a single Boron-Epoxy composite doubler to the damaged structure. The FAA's Airworthiness Assurance Center at Sandia National Labs (AANC), Boeing, and Federal Express completed a pilot program to validate and introduce composite doubler repair technology to the U.S. commercial aircraft industry. This project focused on repair of DC-10 fuselage structure and its primary goal was to demonstrate routine use of this repair technology using niche applications that streamline the design-to-installation process. As composite doubler repairs gradually appear in the commercial aircraft arena, successful flight operation data is being accumulated. These commercial aircraft repairs are not only demonstrating the engineering and economic advantages of composite doubler technology but they are also establishing the ability of commercial maintenance depots to safely adopt this repair technique. This report presents the array of engineering activities that were completed in order to make this technology available for widespread commercial aircraft use. Focused laboratory testing was conducted to compliment the field data and to address specific issues regarding damage tolerance and flaw growth in composite doubler repairs. Fatigue and strength tests were performed on a simulated wing

  11. Mutations in COL1A1 and COL1A2 and dental aberrations in children and adolescents with osteogenesis imperfecta - A retrospective cohort study.

    Directory of Open Access Journals (Sweden)

    Kristofer Andersson

    Full Text Available Osteogenesis imperfecta (OI is a heterogeneous group of disorders of connective tissue, caused mainly by mutations in the collagen I genes (COL1A1 and COL1A2. Dentinogenesis imperfecta (DGI and other dental aberrations are common features of OI. We investigated the association between collagen I mutations and DGI, taurodontism, and retention of permanent second molars in a retrospective cohort of 152 unrelated children and adolescents with OI. The clinical examination included radiographic evaluations. Teeth from 81 individuals were available for histopathological evaluation. COL1A1/2 mutations were found in 104 individuals by nucleotide sequencing. DGI was diagnosed clinically and radiographically in 29% of the individuals (44/152 and through isolated histological findings in another 19% (29/152. In the individuals with a COL1A1 mutation, 70% (7/10 of those with a glycine substitution located C-terminal of p.Gly305 exhibited DGI in both dentitions while no individual (0/7 with a mutation N-terminal of this point exhibited DGI in either dentition (p = 0.01. In the individuals with a COL1A2 mutation, 80% (8/10 of those with a glycine substitution located C terminal of p.Gly211 exhibited DGI in both dentitions while no individual (0/5 with a mutation N-terminal of this point (p = 0.007 exhibited DGI in either dentition. DGI was restricted to the deciduous dentition in 20 individuals. Seventeen had missense mutations where glycine to serine was the most prevalent substitution (53%. Taurodontism occurred in 18% and retention of permanent second molars in 31% of the adolescents. Dental aberrations are strongly associated with qualitatively changed collagen I. The varying expressivity of DGI is related to the location of the collagen I mutation. Genotype information may be helpful in identifying individuals with OI who have an increased risk of dental aberrations.

  12. Mutations in COL1A1 and COL1A2 and dental aberrations in children and adolescents with osteogenesis imperfecta – A retrospective cohort study

    Science.gov (United States)

    Dahllöf, Göran; Lindahl, Katarina; Kindmark, Andreas; Grigelioniene, Giedre; Åström, Eva; Malmgren, Barbro

    2017-01-01

    Osteogenesis imperfecta (OI) is a heterogeneous group of disorders of connective tissue, caused mainly by mutations in the collagen I genes (COL1A1 and COL1A2). Dentinogenesis imperfecta (DGI) and other dental aberrations are common features of OI. We investigated the association between collagen I mutations and DGI, taurodontism, and retention of permanent second molars in a retrospective cohort of 152 unrelated children and adolescents with OI. The clinical examination included radiographic evaluations. Teeth from 81 individuals were available for histopathological evaluation. COL1A1/2 mutations were found in 104 individuals by nucleotide sequencing. DGI was diagnosed clinically and radiographically in 29% of the individuals (44/152) and through isolated histological findings in another 19% (29/152). In the individuals with a COL1A1 mutation, 70% (7/10) of those with a glycine substitution located C-terminal of p.Gly305 exhibited DGI in both dentitions while no individual (0/7) with a mutation N-terminal of this point exhibited DGI in either dentition (p = 0.01). In the individuals with a COL1A2 mutation, 80% (8/10) of those with a glycine substitution located C terminal of p.Gly211 exhibited DGI in both dentitions while no individual (0/5) with a mutation N-terminal of this point (p = 0.007) exhibited DGI in either dentition. DGI was restricted to the deciduous dentition in 20 individuals. Seventeen had missense mutations where glycine to serine was the most prevalent substitution (53%). Taurodontism occurred in 18% and retention of permanent second molars in 31% of the adolescents. Dental aberrations are strongly associated with qualitatively changed collagen I. The varying expressivity of DGI is related to the location of the collagen I mutation. Genotype information may be helpful in identifying individuals with OI who have an increased risk of dental aberrations. PMID:28498836

  13. Scoliosis in osteogenesis imperfecta caused by COL1A1/COL1A2 mutations - genotype-phenotype correlations and effect of bisphosphonate treatment.

    Science.gov (United States)

    Sato, Atsuko; Ouellet, Jean; Muneta, Takeshi; Glorieux, Francis H; Rauch, Frank

    2016-05-01

    Bisphosphonates are widely used to treat children with osteogenesis imperfecta (OI), a bone fragility disorder that is most often caused by mutations in COL1A1 or COL1A2. However, it is unclear whether this treatment decreases the risk of developing scoliosis. We retrospectively evaluated spine radiographs and charts of 437 patients (227 female) with OI caused by mutations in COL1A1 or COL1A2 and compared the relationship between scoliosis, genotype and bisphosphonate treatment history. At the last follow-up (mean age 11.9 [SD: 5.9] years), 242 (55%) patients had scoliosis. The prevalence of scoliosis was highest in OI type III (89%), followed by OI type IV (61%) and OI type I (36%). Moderate to severe scoliosis (Cobb angle ≥25°) was rare in individuals with COL1A1 haploinsufficiency mutations but was present in about two fifth of patients with triple helical glycine substitutions or C-propeptide mutations. During the first 2 to 4years of bisphosphonate therapy, patients with OI type III had lower Cobb angle progression rates than before bisphosphonate treatment, whereas in OI types I and IV bisphosphonate treatment was not associated with a change in Cobb angle progression rates. At skeletal maturity, the prevalence of scoliosis (Cobb angle >10°) was similar in patients who had started bisphosphonate treatment early in life (before 5.0years of age) and in patients who had started therapy later (after the age of 10.0years) or had never received bisphosphonate therapy. Bisphosphonate treatment decreased progression rate of scoliosis in OI type III but there was no evidence of a positive effect on scoliosis in OI types I and IV. The prevalence of scoliosis at maturity was not influenced by the bisphosphonate treatment history in any OI type. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Mutations in COL1A1 and COL1A2 and dental aberrations in children and adolescents with osteogenesis imperfecta - A retrospective cohort study.

    Science.gov (United States)

    Andersson, Kristofer; Dahllöf, Göran; Lindahl, Katarina; Kindmark, Andreas; Grigelioniene, Giedre; Åström, Eva; Malmgren, Barbro

    2017-01-01

    Osteogenesis imperfecta (OI) is a heterogeneous group of disorders of connective tissue, caused mainly by mutations in the collagen I genes (COL1A1 and COL1A2). Dentinogenesis imperfecta (DGI) and other dental aberrations are common features of OI. We investigated the association between collagen I mutations and DGI, taurodontism, and retention of permanent second molars in a retrospective cohort of 152 unrelated children and adolescents with OI. The clinical examination included radiographic evaluations. Teeth from 81 individuals were available for histopathological evaluation. COL1A1/2 mutations were found in 104 individuals by nucleotide sequencing. DGI was diagnosed clinically and radiographically in 29% of the individuals (44/152) and through isolated histological findings in another 19% (29/152). In the individuals with a COL1A1 mutation, 70% (7/10) of those with a glycine substitution located C-terminal of p.Gly305 exhibited DGI in both dentitions while no individual (0/7) with a mutation N-terminal of this point exhibited DGI in either dentition (p = 0.01). In the individuals with a COL1A2 mutation, 80% (8/10) of those with a glycine substitution located C terminal of p.Gly211 exhibited DGI in both dentitions while no individual (0/5) with a mutation N-terminal of this point (p = 0.007) exhibited DGI in either dentition. DGI was restricted to the deciduous dentition in 20 individuals. Seventeen had missense mutations where glycine to serine was the most prevalent substitution (53%). Taurodontism occurred in 18% and retention of permanent second molars in 31% of the adolescents. Dental aberrations are strongly associated with qualitatively changed collagen I. The varying expressivity of DGI is related to the location of the collagen I mutation. Genotype information may be helpful in identifying individuals with OI who have an increased risk of dental aberrations.

  15. ColVI myopathies: where do we stand, where do we go?

    Directory of Open Access Journals (Sweden)

    Allamand Valérie

    2011-09-01

    Full Text Available Abstract Collagen VI myopathies, caused by mutations in the genes encoding collagen type VI (ColVI, represent a clinical continuum with Ullrich congenital muscular dystrophy (UCMD and Bethlem myopathy (BM at each end of the spectrum, and less well-defined intermediate phenotypes in between. ColVI myopathies also share common features with other disorders associated with prominent muscle contractures, making differential diagnosis difficult. This group of disorders, under-recognized for a long time, has aroused much interest over the past decade, with important advances made in understanding its molecular pathogenesis. Indeed, numerous mutations have now been reported in the COL6A1, COL6A2 and COL6A3 genes, a large proportion of which are de novo and exert dominant-negative effects. Genotype-phenotype correlations have also started to emerge, which reflect the various pathogenic mechanisms at play in these disorders: dominant de novo exon splicing that enables the synthesis and secretion of mutant tetramers and homozygous nonsense mutations that lead to premature termination of translation and complete loss of function are associated with early-onset, severe phenotypes. In this review, we present the current state of diagnosis and research in the field of ColVI myopathies. The past decade has provided significant advances, with the identification of altered cellular functions in animal models of ColVI myopathies and in patient samples. In particular, mitochondrial dysfunction and a defect in the autophagic clearance system of skeletal muscle have recently been reported, thereby opening potential therapeutic avenues.

  16. 78 FR 20229 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-04-04

    ... replacement of any discrepant elevator tab control mechanism. This new AD requires replacing the left and... vibration; and reports of gaps in elevator tab control mechanisms and analysis indicating that additional... Equipment Branch, ANM-130S, FAA, Seattle Aircraft Certification Office (ACO), 1601 Lind Avenue SW., Renton...

  17. 77 FR 24357 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-04-24

    ... to increased lightning-induced currents and subsequent damage to composite structures, hydraulic... lightning-induced currents and subsequent damage to composite structures, hydraulic tubes, and actuator..., ANM-130S, Seattle Aircraft Certification Office (ACO), FAA, 1601 Lind Avenue SW., Renton, Washington...

  18. 77 FR 20511 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-04-05

    ... any cold-bonding methods that would be applicable to the composite TR inner wall on the affected airplanes. Current SRM repair methods for composite structure involve either autoclave or vacuum bag/heat... Parker, Aerospace Engineer, Propulsion Branch, ANM-140S, FAA, Seattle Aircraft Certification Office (ACO...

  19. CID Aircraft post-impact lakebed skid

    Science.gov (United States)

    1984-01-01

    Moments after hitting and sliding through the wing openers the aircraft burst into flame, with a spectacular fireball seen emanating from the right inboard engine area. In a typical aircraft crash, fuel spilled from ruptured fuel tanks forms a fine mist that can be ignited by a number of sources at the crash site. In 1984 the NASA Dryden Flight Research Facility (after 1994 a full-fledged Center again) and the Federal Aviation Administration (FAA) teamed-up in a unique flight experiment called the Controlled Impact Demonstration (CID), to test crash a Boeing 720 aircraft using standard fuel with an additive designed to supress fire. The additive, FM-9, a high-molecular-weight long-chain polymer, when blended with Jet-A fuel had demonstrated the capability to inhibit ignition and flame propagation of the released fuel in simulated crash tests. This anti-misting kerosene (AMK) cannot be introduced directly into a gas turbine engine due to several possible problems such as clogging of filters. The AMK must be restored to almost Jet-A before being introduced into the engine for burning. This restoration is called 'degradation' and was accomplished on the B-720 using a device called a 'degrader.' Each of the four Pratt & Whitney JT3C-7 engines had a 'degrader' built and installed by General Electric (GE) to break down and return the AMK to near Jet-A quality. In addition to the AMK research the NASA Langley Research Center was involved in a structural loads measurement experiment, which included having instrumented dummies filling the seats in the passenger compartment. Before the final flight on December 1, 1984, more than four years of effort passed trying to set-up final impact conditions considered survivable by the FAA. During those years while 14 flights with crews were flown the following major efforts were underway: NASA Dryden developed the remote piloting techniques necessary for the B-720 to fly as a drone aircraft; General Electric installed and tested four

  20. Aircraft operations management manual

    Science.gov (United States)

    1992-01-01

    The NASA aircraft operations program is a multifaceted, highly diverse entity that directly supports the agency mission in aeronautical research and development, space science and applications, space flight, astronaut readiness training, and related activities through research and development, program support, and mission management aircraft operations flights. Users of the program are interagency, inter-government, international, and the business community. This manual provides guidelines to establish policy for the management of NASA aircraft resources, aircraft operations, and related matters. This policy is an integral part of and must be followed when establishing field installation policy and procedures covering the management of NASA aircraft operations. Each operating location will develop appropriate local procedures that conform with the requirements of this handbook. This manual should be used in conjunction with other governing instructions, handbooks, and manuals.

  1. Turboelectric Distributed Propulsion in a Hybrid Wing Body Aircraft

    Science.gov (United States)

    Felder, James L.; Brown, Gerald V.; DaeKim, Hyun; Chu, Julio

    2011-01-01

    The performance of the N3-X, a 300 passenger hybrid wing body (HWB) aircraft with turboelectric distributed propulsion (TeDP), has been analyzed to see if it can meet the 70% fuel burn reduction goal of the NASA Subsonic Fixed Wing project for N+3 generation aircraft. The TeDP system utilizes superconducting electric generators, motors and transmission lines to allow the power producing and thrust producing portions of the system to be widely separated. It also allows a small number of large turboshaft engines to drive any number of propulsors. On the N3-X these new degrees of freedom were used to (1) place two large turboshaft engines driving generators in freestream conditions to maximize thermal efficiency and (2) to embed a broad continuous array of 15 motor driven propulsors on the upper surface of the aircraft near the trailing edge. That location maximizes the amount of the boundary layer ingested and thus maximizes propulsive efficiency. The Boeing B777-200LR flying 7500 nm (13890 km) with a cruise speed of Mach 0.84 and an 118100 lb payload was selected as the reference aircraft and mission for this study. In order to distinguish between improvements due to technology and aircraft configuration changes from those due to the propulsion configuration changes, an intermediate configuration was included in this study. In this configuration a pylon mounted, ultra high bypass (UHB) geared turbofan engine with identical propulsion technology was integrated into the same hybrid wing body airframe. That aircraft achieved a 52% reduction in mission fuel burn relative to the reference aircraft. The N3-X was able to achieve a reduction of 70% and 72% (depending on the cooling system) relative to the reference aircraft. The additional 18% - 20% reduction in the mission fuel burn can therefore be attributed to the additional degrees of freedom in the propulsion system configuration afforded by the TeDP system that eliminates nacelle and pylon drag, maximizes boundary

  2. Down syndrome related muscle hypotonia: association with COL6A3 functional SNP rs2270669

    Directory of Open Access Journals (Sweden)

    Arpita eDey

    2013-04-01

    Full Text Available Down syndrome (DS, the principal cause for intellectual disability, is also associated with hormonal, immunological, and gastrointestinal abnormalities. Muscle hypotonia (MH and congenital heart diseases (CHD are also frequently observed. Collagen molecules are essential components for maintaining muscle integrity and are formed by the assembly of three chains, alpha 1-3. The type VI collagen is crucial for cardiac as well as skeletal muscles. The COL 1 (VI and 2 (VI chains are encoded by genes located at the 21st chromosome and are expected to have higher dosage in individuals with DS. The  3 (VI chain is encoded by the COL6A3 located at the chromosome 2. We hypothesized that apart from COL6A1 and COL6A2, COL6A3 may also have some role in the MH of subjects with DS. To find out the relevance of COL6A3 in DS associated MH and CHD, we genotyped two SNPs in COL6A3, rs2270669 and rs2270668, in individuals with DS. Subjects with DS were recruited based on the Diagnostic and Statistical Manual for Mental Disorders-IV and having trisomy of the 21st chromosome. Parents of individuals with DS and ethnically matched controls were enrolled for comparison. Informed written consent was obtained for participation. Peripheral blood was used for isolation of genomic DNA. Target genetic loci were studied by DNA sequence analysis. Data obtained was subjected to population- as well as family-based statistical analysis. rs2270668 was found to be nonpolymorphic in the studied population. rs2270669 showed significant association of the ‘C’ allele and ‘CC’ genotype with DS probands having MH (P=0.02. Computational analysis showed that rs2270669 may induce structural and functional alterations in the COL 3 (VI. Interaction of COL3 (VI with different proteins, crucial for muscle integrity, was also noticed by computational methods. This pioneering study on COL6A3 with DS related MH thus indicates that rs2270669 ‘C’ could be considered as a

  3. A COL11A2 mutation in Labrador retrievers with mild disproportionate dwarfism.

    Directory of Open Access Journals (Sweden)

    Mirjam Frischknecht

    Full Text Available We describe a mild form of disproportionate dwarfism in Labrador Retrievers, which is not associated with any obvious health problems such as secondary arthrosis. We designate this phenotype as skeletal dysplasia 2 (SD2. It is inherited as a monogenic autosomal recessive trait with incomplete penetrance primarily in working lines of the Labrador Retriever breed. Using 23 cases and 37 controls we mapped the causative mutation by genome-wide association and homozygosity mapping to a 4.44 Mb interval on chromosome 12. We re-sequenced the genome of one affected dog at 30x coverage and detected 92 non-synonymous variants in the critical interval. Only two of these variants, located in the lymphotoxin A (LTA and collagen alpha-2(XI chain gene (COL11A2, respectively, were perfectly associated with the trait. Previously described COL11A2 variants in humans or mice lead to skeletal dysplasias and/or deafness. The dog variant associated with disproportionate dwarfism, COL11A2:c.143G>C or p.R48P, probably has only a minor effect on collagen XI function, which might explain the comparatively mild phenotype seen in our study. The identification of this candidate causative mutation thus widens the known phenotypic spectrum of COL11A2 mutations. We speculate that non-pathogenic COL11A2 variants might even contribute to the heritable variation in height.

  4. Case of Small Vessel Disease Associated with COL4A1 Mutations following Trauma

    Directory of Open Access Journals (Sweden)

    Joao McONeil Plancher

    2015-06-01

    Full Text Available With this case report, we would like to heighten the awareness of clinicians about COL4A1 as a single-gene disorder causing cerebral small vessel disease and describe a previously unreported pathogenic missense substitution in COL4A1 (p.Gly990Val and a new clinical presentation. We identified a heterozygous putatively pathogenic mutation of COL4A1 in a 50-year-old female with a history of congenital cataracts and glaucoma who presented with multiple diffusion-positive infarcts and areas of contrast enhancement following mild head trauma. We believe that this presentation of multiple areas of acute brain and vascular injury in the setting of mild head trauma is a new manifestation of this genetic disorder. Imaging findings of multiple acute infarcts and regions of contrast enhancement with associated asymptomatic old deep microhemorrhages and leukomalacia in adults after head trauma should raise a high suspicion for a COL4A1 genetic disorder. Radiographic patterns of significant leukoaraiosis and deep microhemorrhages can also be seen in patients with long-standing vasculopathy associated with hypertension, which our patient lacked. Our findings demonstrate the utility of genetic screening for COL4A1 mutations in young patients who have small vessel vasculopathy on brain imaging but who do not have significant cardiovascular risk factors.

  5. COL Application Content Guide for HTGRs: Revision to RG 1.206, Part 1 - Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Wayne Moe

    2012-08-01

    A combined license (COL) application is required by the Nuclear Regulatory Commission (NRC) for all proposed nuclear plants. The information requirements for a COL application are set forth in 10 CFR 52.79, “Contents of Applications; Technical Information in Final Safety Analysis Report.” An applicant for a modular high temperature gas-cooled reactor (HTGR) must develop and submit for NRC review and approval a COL application which conforms to these requirements. The technical information necessary to allow NRC staff to evaluate a COL application and resolve all safety issues related to a proposed nuclear plant is detailed and comprehensive. To this, Regulatory Guide (RG) 1.206, “Combined License Applications for Nuclear Power Plants” (LWR Edition), was developed to assist light water reactor (LWR) applicants in incorporating and effectively formatting required information for COL application review (Ref. 1). However, the guidance prescribed in RG 1.206 presumes a LWR design proposal consistent with the systems and functions associated with large LWR power plants currently operating under NRC license.

  6. Ares I Aerodynamic Testing at the Boeing Polysonic Wind Tunnel

    Science.gov (United States)

    Pinier, Jeremy T.; Niskey, Charles J.; Hanke, Jeremy L.; Tomek, William G.

    2011-01-01

    Throughout three full design analysis cycles, the Ares I project within the Constellation program has consistently relied on the Boeing Polysonic Wind Tunnel (PSWT) for aerodynamic testing of the subsonic, transonic and supersonic portions of the atmospheric flight envelope (Mach=0.5 to 4.5). Each design cycle required the development of aerodynamic databases for the 6 degree-of-freedom (DOF) forces and moments, as well as distributed line-loads databases covering the full range of Mach number, total angle-of-attack, and aerodynamic roll angle. The high fidelity data collected in this facility has been consistent with the data collected in NASA Langley s Unitary Plan Wind Tunnel (UPWT) at the overlapping condition ofMach=1.6. Much insight into the aerodynamic behavior of the launch vehicle during all phases of flight was gained through wind tunnel testing. Important knowledge pertaining to slender launch vehicle aerodynamics in particular was accumulated. In conducting these wind tunnel tests and developing experimental aerodynamic databases, some challenges were encountered and are reported as lessons learned in this paper for the benefit of future crew launch vehicle aerodynamic developments.

  7. Predicting visibility of aircraft.

    Science.gov (United States)

    Watson, Andrew; Ramirez, Cesar V; Salud, Ellen

    2009-05-20

    Visual detection of aircraft by human observers is an important element of aviation safety. To assess and ensure safety, it would be useful to be able to be able to predict the visibility, to a human observer, of an aircraft of specified size, shape, distance, and coloration. Examples include assuring safe separation among aircraft and between aircraft and unmanned vehicles, design of airport control towers, and efforts to enhance or suppress the visibility of military and rescue vehicles. We have recently developed a simple metric of pattern visibility, the Spatial Standard Observer (SSO). In this report we examine whether the SSO can predict visibility of simulated aircraft images. We constructed a set of aircraft images from three-dimensional computer graphic models, and measured the luminance contrast threshold for each image from three human observers. The data were well predicted by the SSO. Finally, we show how to use the SSO to predict visibility range for aircraft of arbitrary size, shape, distance, and coloration.

  8. Tropospheric sampling with aircraft

    Energy Technology Data Exchange (ETDEWEB)

    Daum, P.H.; Springston, S.R.

    1991-03-01

    Aircraft constitute a unique environment which places stringent requirements on the instruments used to measure the concentrations of atmospheric trace gases and aerosols. Some of these requirements such as minimization of size, weight, and power consumption are general; others are specific to individual techniques. This review presents the basic principles and considerations governing the deployment of trace gas and aerosol instrumentation on an aircraft. An overview of common instruments illustrates these points and provides guidelines for designing and using instruments on aircraft-based measurement programs.

  9. CID Aircraft pre-impact lakebed skid

    Science.gov (United States)

    1984-01-01

    The B-720 is seen viewed moments after impact and just before hitting the wing openers. In a typical aircraft crash, fuel spilled from ruptured fuel tanks forms a fine mist that can be ignited by a number of sources at the crash site. In 1984 the NASA Dryden Flight Research Facility (after 1994 a full-fledged Center again) and the Federal Aviation Administration (FAA) teamed-up in a unique flight experiment called the Controlled Impact Demonstration (CID), to test crash a Boeing 720 aircraft using standard fuel with an additive designed to supress fire. The additive, FM-9, a high-molecular-weight long-chain polymer, when blended with Jet-A fuel had demonstrated the capability to inhibit ignition and flame propagation of the released fuel in simulated crash tests. This anti-misting kerosene (AMK) cannot be introduced directly into a gas turbine engine due to several possible problems such as clogging of filters. The AMK must be restored to almost Jet-A before being introduced into the engine for burning. This restoration is called 'degradation' and was accomplished on the B-720 using a device called a 'degrader.' Each of the four Pratt & Whitney JT3C-7 engines had a 'degrader' built and installed by General Electric (GE) to break down and return the AMK to near Jet-A quality. In addition to the AMK research the NASA Langley Research Center was involved in a structural loads measurement experiment, which included having instrumented dummies filling the seats in the passenger compartment. Before the final flight on December 1, 1984, more than four years of effort passed trying to set-up final impact conditions considered survivable by the FAA. During those years while 14 flights with crews were flown the following major efforts were underway: NASA Dryden developed the remote piloting techniques necessary for the B-720 to fly as a drone aircraft; General Electric installed and tested four degraders (one on each engine); and the FAA refined AMK (blending, testing, and

  10. The effects of the aircraft cabin environment on passengers during simulated flights

    DEFF Research Database (Denmark)

    Strøm-Tejsen, Peter

    2007-01-01

    A 3-row, 21-seat section of a simulated Boeing 767 aircraft cabin has been built in a climate chamber, simulating the cabin environment not only in terms of materials and geometry, but also in terms of cabin air and wall temperatures and ventilation with very dry air. This realistic simulation en...... of air quality, air freshness, and thermal sensation, improving these perceptions when temperature was lowered....... of the symptoms commonly associated with the aircraft cabin. It suggests that it would be beneficial to remove ozone at levels less than currently specified. The last study, investigating the influence of air temperature on passenger comfort and symptoms, showed that cabin air temperature affected the perception...

  11. Description and flight performance of two systems for two-segment approach. [for aircraft noise abatement

    Science.gov (United States)

    Wehrend, W. R.; Shigemoto, F. H.; Bourquin, K. R.

    1974-01-01

    This paper describes two different avionic systems which were designed and developed to provide guidance and control for two-segment noise abatement approaches. The concept of a low-cost retrofit avionic system evolved into a special-purpose two-segment computer which required a DME collocated with the ILS glide-slope transmitter. This system was evaluated in a Boeing 727-200 aircraft. The second system is an area navigation (RNAV) system modified to include the two-segment approach. This system is more sophisticated than the first system and does not restrict usage to any specific navigation ground aid. The modified RNAV system is a Collins ANS-70A and is currently being evaluated in a DC-8-61 aircraft.

  12. Traitement chirurgical des fractures du col du femur de l'adulte par ...

    African Journals Online (AJOL)

    Patients et méthodes : Il s'est agi d'une étude rétrospective de 8 ans allant du 1er janvier 2006 au 31 décembre 2013 et portant sur 44 cas de fractures du col fémoral traités par des prothèses cervico-céphaliques de Moore ou de Thompson. Résultats : Quarante-quatre (44) cas de fractures du col fémoral étaient inclus dans ...

  13. Role of commercial aircraft in global monitoring systems.

    Science.gov (United States)

    Steinberg, R

    1973-04-27

    The role of commercial aircraft in monitoring meteorological parameters and atmospheric constituents has been limited in the former case and virtually nonexistent in the latter. I have tried to point out that this situation can and should be changed now. The new family of wide-bodied jets such as the 747, DC-10, and L-1011 aircraft can be used to supply important global atmospheric and tropical meteorological data for which there is a pressing need. While scientists are not in total agreement on the magnitude of the effect of particulates and gases on the atmosphere, there is almost unanimous concurrence that we are severely limited in information, and that global baseline concentrations must be established for particulates and gases in the troposphere and lower stratosphere as soon as possible. Also, more synoptic meteorological information from the tropical troposphere is highly desirable. In the final analysis, commercial aircraft may offer the most inexpensive way to monitor our atmosphere in the near future. Much of the instrumentation technology is here and the rest is certainly within our grasp. The fact of the matter is that there are now over 220 Boeing 747's and Douglas DC-10's in service, flying an average of 10 hours a day. Long-range flights, such as those from Tokyo to Anchorage to London in the Northern Hemisphere and from Hawaii to Pago Pago to Sydney in the Southern Hemisphere, are commonplace. These aircraft are equipped with inertial navigation systems and central air data computers coupled to advanced data storage systems which can readily be interrogated by satellite. This means that there is now a large amount of snyoptic weather information which can be obtained with a minimum of effort and cost. Likewise, a start at obtaining measurements of atmospheric constituents on a global basis can be made now. All we need to do is make the effort.

  14. Development of Stitched Composite Structure for Advanced Aircraft

    Science.gov (United States)

    Jegley, Dawn; Przekop, Adam; Rouse, Marshall; Lovejoy, Andrew; Velicki, Alex; Linton, Kim; Wu, Hsi-Yung; Baraja, Jaime; Thrash, Patrick; Hoffman, Krishna

    2015-01-01

    NASA has created the Environmentally Responsible Aviation Project to develop technologies which will reduce the impact of aviation on the environment. A critical aspect of this pursuit is the development of a lighter, more robust airframe that will enable the introduction of unconventional aircraft configurations. NASA and The Boeing Company are working together to develop a structural concept that is lightweight and an advancement beyond state-of-the-art composites. The Pultruded Rod Stitched Efficient Unitized Structure (PRSEUS) is an integrally stiffened panel design where elements are stitched together and designed to maintain residual load-carrying capabilities under a variety of damage scenarios. With the PRSEUS concept, through-the-thickness stitches are applied through dry fabric prior to resin infusion, and replace fasteners throughout each integral panel. Through-the-thickness reinforcement at discontinuities, such as along flange edges, has been shown to suppress delamination and turn cracks, which expands the design space and leads to lighter designs. The pultruded rod provides stiffening away from the more vulnerable skin surface and improves bending stiffness. A series of building blocks were evaluated to explore the fundamental assumptions related to the capability and advantages of PRSEUS panels. These building blocks addressed tension, compression, and pressure loading conditions. The emphasis of the development work has been to assess the loading capability, damage arrestment features, repairability, post-buckling behavior, and response of PRSEUS flat panels to out-of plane pressure loading. The results of this building-block program from coupons through an 80%-scale pressure box have demonstrated the viability of a PRSEUS center body for the Hybrid Wing Body (HWB) transport aircraft. This development program shows that the PRSEUS benefits are also applicable to traditional tube-andwing aircraft, those of advanced configurations, and other

  15. Depreciation of aircraft

    Science.gov (United States)

    Warner, Edward P

    1922-01-01

    There is a widespread, and quite erroneous, impression to the effect that aircraft are essentially fragile and deteriorate with great rapidity when in service, so that the depreciation charges to be allowed on commercial or private operation are necessarily high.

  16. Aircraft Fire Protection Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — The Navy Aircraft Protection Laboratory provides complete test support for all Navy air vehicle fire protection systems.The facility allows for the simulation of a...

  17. Aircraft electromagnetic compatibility

    Science.gov (United States)

    Clarke, Clifton A.; Larsen, William E.

    1987-06-01

    Illustrated are aircraft architecture, electromagnetic interference environments, electromagnetic compatibility protection techniques, program specifications, tasks, and verification and validation procedures. The environment of 400 Hz power, electrical transients, and radio frequency fields are portrayed and related to thresholds of avionics electronics. Five layers of protection for avionics are defined. Recognition is given to some present day electromagnetic compatibility weaknesses and issues which serve to reemphasize the importance of EMC verification of equipment and parts, and their ultimate EMC validation on the aircraft. Proven standards of grounding, bonding, shielding, wiring, and packaging are laid out to help provide a foundation for a comprehensive approach to successful future aircraft design and an understanding of cost effective EMC in an aircraft setting.

  18. The Aircraft Industry, 2006

    National Research Council Canada - National Science Library

    Daniel, Keith

    2006-01-01

    .... and global economic growth. The overall outlook for the industry is positive. Orders for commercial aircraft are up from a boom in air travel that is likely to continue well into the next decade...

  19. Solar thermal aircraft

    Science.gov (United States)

    Bennett, Charles L.

    2007-09-18

    A solar thermal powered aircraft powered by heat energy from the sun. A heat engine, such as a Stirling engine, is carried by the aircraft body for producing power for a propulsion mechanism, such as a propeller. The heat engine has a thermal battery in thermal contact with it so that heat is supplied from the thermal battery. A solar concentrator, such as reflective parabolic trough, is movably connected to an optically transparent section of the aircraft body for receiving and concentrating solar energy from within the aircraft. Concentrated solar energy is collected by a heat collection and transport conduit, and heat transported to the thermal battery. A solar tracker includes a heliostat for determining optimal alignment with the sun, and a drive motor actuating the solar concentrator into optimal alignment with the sun based on a determination by the heliostat.

  20. The Aircraft Morphing Program

    Science.gov (United States)

    Wlezien, R. W.; Horner, G. C.; McGowan, A. R.; Padula, S. L.; Scott, M. A.; Silcox, R. J.; Simpson, J. O.

    1998-01-01

    In the last decade smart technologies have become enablers that cut across traditional boundaries in materials science and engineering. Here we define smart to mean embedded actuation, sensing, and control logic in a tightly coupled feedback loop. While multiple successes have been achieved in the laboratory, we have yet to see the general applicability of smart devices to real aircraft systems. The NASA Aircraft Morphing program is an attempt to couple research across a wide range of disciplines to integrate smart technologies into high payoff aircraft applications. The program bridges research in seven individual disciplines and combines the effort into activities in three primary program thrusts. System studies are used to assess the highest- payoff program objectives, and specific research activities are defined to address the technologies required for development of smart aircraft systems. In this paper we address the overall program goals and programmatic structure, and discuss the challenges associated with bringing the technologies to fruition.

  1. Essentials of aircraft armaments

    CERN Document Server

    Kaushik, Mrinal

    2017-01-01

    This book aims to provide a complete exposure about armaments from their design to launch from the combat aircraft. The book details modern ammunition and their tactical roles in warfare. The proposed book discusses aerodynamics, propulsion, structural as well as navigation, control, and guidance of aircraft armament. It also introduces the various types of ammunition developed by different countries and their changing trends. The book imparts knowledge in the field of design, and development of aircraft armaments to aerospace engineers and covers the role of the United Nations in peacekeeping and disarmament. The book will be very useful to researchers, students, and professionals working in design and manufacturing of aircraft armaments. The book will also serve air force and naval aspirants, and those interested in working on defence research and developments organizations. .

  2. 2002 Industry Studies: Aircraft

    National Research Council Canada - National Science Library

    Anderson, W

    2002-01-01

    .... Nevertheless, the events of 2001 significantly diminished the industry's vitality. Still leading U.S. business in export dollars, the industry has been forced to look for new markets as worldwide aircraft sales have dropped...

  3. Aircraft Fire Safety

    Science.gov (United States)

    1982-05-01

    fabrics of seats, carpets, drapes, lap robes, and sound deadening insulation. Also of concern are the polymeric based plastics used in interior walls...intumescent paints and foams is considered to be feasible; cabin transparencies with improved fire resistance and structure integrity over thermoformed...aircraft fire safety as well as provide a sound basis for further : long-term imp-ovem nts in new aircraft. REFERENCES 1. Final Report of the Special

  4. The Boeing 120 MeV RF linac for FEL research

    International Nuclear Information System (INIS)

    Adamski, J.L.; Gallagher, W.J.; Kennedy, R.C.; Robinson, B.; Shoffstall, D.R.; Tyson, E.L.; Vetter, A.M.; Yeremian, A.D.

    1985-01-01

    A new electron linac for high power, visible wavelength, free electron laser research is under construction at the Boeing Radiation Laboratory in Seattle. The linac is a five section, traveling wave, L band structure with a specialized ''comb'' pulse format of widely separated high charge micropulses. The paper describes the accelerator design and prototyping of key components of the linac. These include a double subharmonic injector and a long pulse phase and amplitude stabilized RF source which have been tested on Boeing's 20 MeV S band linac

  5. A mouse model for dominant collagen VI disorders: heterozygous deletion of Col6a3 Exon 16.

    Science.gov (United States)

    Pan, Te-Cheng; Zhang, Rui-Zhu; Arita, Machiko; Bogdanovich, Sasha; Adams, Sheila M; Gara, Sudheer Kumar; Wagener, Raimund; Khurana, Tejvior S; Birk, David E; Chu, Mon-Li

    2014-04-11

    Dominant and recessive mutations in collagen VI genes, COL6A1, COL6A2, and COL6A3, cause a continuous spectrum of disorders characterized by muscle weakness and connective tissue abnormalities ranging from the severe Ullrich congenital muscular dystrophy to the mild Bethlem myopathy. Herein, we report the development of a mouse model for dominant collagen VI disorders by deleting exon 16 in the Col6a3 gene. The resulting heterozygous mouse, Col6a3(+/d16), produced comparable amounts of normal Col6a3 mRNA and a mutant transcript with an in-frame deletion of 54 bp of triple-helical coding sequences, thus mimicking the most common molecular defect found in dominant Ullrich congenital muscular dystrophy patients. Biosynthetic studies of mutant fibroblasts indicated that the mutant α3(VI) collagen protein was produced and exerted a dominant-negative effect on collagen VI microfibrillar assembly. The distribution of the α3(VI)-like chains of collagen VI was not altered in mutant mice during development. The Col6a3(+/d16) mice developed histopathologic signs of myopathy and showed ultrastructural alterations of mitochondria and sarcoplasmic reticulum in muscle and abnormal collagen fibrils in tendons. The Col6a3(+/d16) mice displayed compromised muscle contractile functions and thereby provide an essential preclinical platform for developing treatment strategies for dominant collagen VI disorders.

  6. Influência do ambiente no desenvolvimento de colônias iniciais de formigas cortadeiras (Atta sexdens rubropilosa

    Directory of Open Access Journals (Sweden)

    Roberto da Silva Camargo

    2013-08-01

    Full Text Available Anualmente, as colônias maduras de Atta spp. produzem formigas aladas, machos e fêmeas, que abandonam a colônia na qual foram produzidas para formarem novas colônias e, dessa forma, continuarem a perpetuação da espécie. A fundação de colônias de Atta spp. sempre envolve grande esforço da rainha, única responsável pelo cultivo do fungo e pelos cuidados consigo mesma e com sua prole. Nesse período de fundação ocorre o consumo de grande parte de suas reservas. O presente estudo investigou como o ambiente influencia o desenvolvimento das colônias recém-fundadas de Atta sexdens rubropilosa. Para tanto, foram comparadas colônias de campo coletadas cinco meses após a revoada e colônias mantidas em laboratório desde o voo nupcial. Foram analisados o peso e o tamanho da população (número de operárias, de larvas, de pupas e de ovos, o tamanho das operárias, o volume e peso do jardim de fungo e o esforço para a fundação dos ninhos (teor de lipídeos e peso das rainhas. Comparadas às colônias de campo, as colônias de laboratório apresentaram maiores valores no tamanho e no peso da população, no volume e no peso do jardim de fungo. As medidas das operárias, por classe de tamanho, não variaram entre as colônias de campo e de laboratório. O esforço da fundação dos ninhos foi maior nas colônias de campo, cujas rainhas apresentaram menor porcentagem de lipídeos e menor peso em relação às colônias de laboratório. Esses resultados demonstram que o ambiente exerce forte influência no desenvolvimento das colônias durante a fase de fundação, bem como sobre o status fisiológico das rainhas, sendo, portanto, a sobrevivência, o desenvolvimento e o sucesso da colônia reflexos das condições do ambiente e do esforço da rainha.

  7. A genetic variant in COL11A1 is functionally associated with lumbar ...

    Indian Academy of Sciences (India)

    WENJUN LIU

    2017-12-14

    Dec 14, 2017 ... target for a novel treatment modality of LDH. Keywords. lumbar disc herniation; COL11A1; polymorphism; pathogenesis. Introduction. Lumbar disc ... treatments, due to the high cost and disability resulted from symptomatic LDH. Therefore, to facilitate preven- tative and therapeutic measures for LDH, it is ...

  8. Severe Hemolytic Jaundice in a Neonate with a Novel COL4A1 Mutation.

    Science.gov (United States)

    Tomotaki, Seiichi; Mizumoto, Hiroshi; Hamabata, Takayuki; Kumakura, Akira; Shiota, Mitsutaka; Arai, Hiroshi; Haginoya, Kazuhiro; Hata, Daisuke

    2016-12-01

    We report our experience with a preterm infant with severe hemolytic jaundice who required exchange transfusion just after birth. The patient was negative for alloimmune hemolysis as a result of maternal-fetal blood type incompatibility, and tests for inherited defects in erythrocyte metabolism, membrane function, and hemoglobin synthesis were normal. We also performed a bone marrow examination, but could not identify the cause of hemolysis. The patient had several other complications, including porencephaly, epilepsy, elevated serum levels of creatine kinase, and persistent microscopic hematuria. Later, we detected a genetic mutation in COL4A1, which was recently found to be associated with hemolytic anemia. We therefore believe that all of the patient's clinical features, including hemolytic anemia, were due to the mutation in COL4A1. Genetic testing for COL4A1 mutations is recommended in neonates who exhibit hemolytic disease of unknown etiology, especially when other complications compatible with COL4A1-related disorders are present. Copyright © 2014. Published by Elsevier B.V.

  9. The COL5A1 gene and musculoskeletal soft-tissue injuries ...

    African Journals Online (AJOL)

    Among other variants the BstUI restriction fragment length polymorphism (RFLP) within the COL5A1 gene has been shown to be over-represented in asymptomatic participants when compared with those with chronic Achilles tendinopathy, and in asymptomatic female participants when compared with those with ACL ...

  10. Two-step method for curing Escherichia coli of ColE1-derived plasmids

    DEFF Research Database (Denmark)

    Hove-Jensen, Bjarne

    2008-01-01

    To cure Escherichia coli for plasmids derived from the ColE1 replicon advantage is taken of the fact that maintenance of this replicon requires a wild-type allele of polA, encoding DNA polymerase I. Curing is achieved by cotransduction of a mutant polA allele with metE::Tn10, fadAB::Tn10 or other...

  11. Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil: Role of COL1A1

    Science.gov (United States)

    Almeida, Lucas; Oliveira, Joyce; Guimarães, Luiz Henrique; Carvalho, Edgar M; Blackwell, Jenefer M

    2015-01-01

    Previous studies have demonstrated a role for wound healing genes in resolution of cutaneous lesions caused by Leishmania spp. in both mice and humans, including the gene FLI1 encoding Friend leukaemia virus integration 1. Reduction of Fli1 expression in mice has been shown to result in up-regulation of collagen type I alpha 1 (Col1a1) and alpha 2 (Col1a2) genes and, conversely, in down-regulation of the matrix metalloproteinase 1 (Mmp1) gene, suggesting that Fli1 suppression is involved in activation of the profibrotic gene program. Here we examined single nucleotide polymorphisms (SNPs) in these genes as risk factors for cutaneous (CL) and mucosal leishmaniasis (ML), and leishmaniasis per se, caused by L. braziliensis in humans. SNPs were genotyped in 168 nuclear families (250 CL; 87 ML cases) and replicated in 157 families (402 CL; 39 ML cases). Family-based association tests (FBAT) showed the strongest association between SNPs rs1061237 (combined P=0.002) and rs2586488 (combined P=0.027) at COL1A1 and CL disease. This contributes to our further understanding of the role of wound healing in the resolution of CL disease, providing potential for therapies modulating COL1A1 via drugs acting on FLI1. PMID:25562121

  12. Severe Hemolytic Jaundice in a Neonate with a Novel COL4A1 Mutation

    Directory of Open Access Journals (Sweden)

    Seiichi Tomotaki

    2016-12-01

    Full Text Available We report our experience with a preterm infant with severe hemolytic jaundice who required exchange transfusion just after birth. The patient was negative for alloimmune hemolysis as a result of maternal–fetal blood type incompatibility, and tests for inherited defects in erythrocyte metabolism, membrane function, and hemoglobin synthesis were normal. We also performed a bone marrow examination, but could not identify the cause of hemolysis. The patient had several other complications, including porencephaly, epilepsy, elevated serum levels of creatine kinase, and persistent microscopic hematuria. Later, we detected a genetic mutation in COL4A1, which was recently found to be associated with hemolytic anemia. We therefore believe that all of the patient's clinical features, including hemolytic anemia, were due to the mutation in COL4A1. Genetic testing for COL4A1 mutations is recommended in neonates who exhibit hemolytic disease of unknown etiology, especially when other complications compatible with COL4A1-related disorders are present.

  13. Indicadores ácido-base de origen natural: el extracto acuoso de la col lombarda.

    OpenAIRE

    Milla González, Miguel

    2014-01-01

    Después de hacer un breve repaso del concepto “indicador ácido-base” y su empleo en las volumetrías de este tipo, se lleva a cabo un experimento de laboratorio utilizando el extracto de la col morada para ver los cambios de color de dicho extracto al modificar el pH del medio.

  14. Col F.F. Pienaar's Boer war diary (Part I) | Picard | Scientia Militaria ...

    African Journals Online (AJOL)

    Scientia Militaria: South African Journal of Military Studies. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 23, No 3 (1993) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. Col F.F. Pienaar's Boer war diary ...

  15. Lt Col F.F. Pienaar's boer war diary | Picard | Scientia Militaria: South ...

    African Journals Online (AJOL)

    Scientia Militaria: South African Journal of Military Studies. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 23, No 4 (1993) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. Lt Col F.F. Pienaar's boer war ...

  16. Effects of a malfunctional column on conventional and FeedCol-simulated moving bed chromatography performance.

    Science.gov (United States)

    Song, Ji-Yeon; Oh, Donghoon; Lee, Chang-Ha

    2015-07-17

    The effects of a malfunctional column on the performance of a simulated moving bed (SMB) process were studied experimentally and theoretically. The experimental results of conventional four-zone SMB (2-2-2-2 configuration) and FeedCol operation (2-2-2-2 configuration with one feed column) with one malfunctional column were compared with simulation results of the corresponding SMB processes with a normal column configuration. The malfunctional column in SMB processes significantly deteriorated raffinate purity. However, the extract purity was equivalent or slightly improved compared with the corresponding normal SMB operation because the complete separation zone of the malfunctional column moved to a lower flow rate range in zones II and III. With the malfunctional column configuration, FeedCol operation gave better experimental performance (up to 7%) than conventional SMB operation because controlling product purity with FeedCol operation was more flexible through the use of two additional operating variables, injection time and injection length. Thus, compared with conventional SMB separation, extract with equivalent or slightly better purity could be produced from FeedCol operation even with a malfunctional column, while minimizing the decrease in raffinate purity (less than 2%). Copyright © 2015 Elsevier B.V. All rights reserved.

  17. DICE/ColDICE: 6D collisionless phase space hydrodynamics using a lagrangian tesselation

    Science.gov (United States)

    Sousbie, Thierry

    2018-01-01

    DICE is a C++ template library designed to solve collisionless fluid dynamics in 6D phase space using massively parallel supercomputers via an hybrid OpenMP/MPI parallelization. ColDICE, based on DICE, implements a cosmological and physical VLASOV-POISSON solver for cold systems such as dark matter (CDM) dynamics.

  18. Population haplotype analysis and evolutionary relations of the COL2A1 gene

    NARCIS (Netherlands)

    Meulenbelt, I.; Williams, G.J.; Koppele, J.M.T.E.; Giessen, G.C.D.E. van; Slagboom, P.E.

    1996-01-01

    We have determined the allele frequencies mad pairwise linkage disequilibria of restriction fragment length polymorphisms (RFLPs) distributed over the entire COL2A1 gene (spanning 23 · 6 kb) in a population of unrelated Dutch Caucasians. Pairwise linkage disequilibrium analysis of RFLP sites between

  19. Open Rotor Noise Shielding by Blended-Wing-Body Aircraft

    Science.gov (United States)

    Guo, Yueping; Czech, Michael J.; Thomas, Russell H.

    2015-01-01

    This paper presents an analysis of open rotor noise shielding by Blended Wing Body (BWB) aircraft by using model scale test data acquired in the Boeing Low Speed Aeroacoustic Facility (LSAF) with a legacy F7/A7 rotor model and a simplified BWB platform. The objective of the analysis is the understanding of the shielding features of the BWB and the method of application of the shielding data for noise studies of BWB aircraft with open rotor propulsion. By studying the directivity patterns of individual tones, it is shown that though the tonal energy distribution and the spectral content of the wind tunnel test model, and thus its total noise, may differ from those of more advanced rotor designs, the individual tones follow directivity patterns that characterize far field radiations of modern open rotors, ensuring the validity of the use of this shielding data. Thus, open rotor tonal noise shielding should be categorized into front rotor tones, aft rotor tones and interaction tones, not only because of the different directivities of the three groups of tones, but also due to the differences in their source locations and coherence features, which make the respective shielding characteristics of the three groups of tones distinctly different from each other. To reveal the parametric trends of the BWB shielding effects, results are presented with variations in frequency, far field emission angle, rotor operational condition, engine installation geometry, and local airframe features. These results prepare the way for the development of parametric models for the shielding effects in prediction tools.

  20. Composite Structure Modeling and Analysis of Advanced Aircraft Fuselage Concepts

    Science.gov (United States)

    Mukhopadhyay, Vivek; Sorokach, Michael R.

    2015-01-01

    NASA Environmentally Responsible Aviation (ERA) project and the Boeing Company are collabrating to advance the unitized damage arresting composite airframe technology with application to the Hybrid-Wing-Body (HWB) aircraft. The testing of a HWB fuselage section with Pultruded Rod Stitched Efficient Unitized Structure (PRSEUS) construction is presently being conducted at NASA Langley. Based on lessons learned from previous HWB structural design studies, improved finite-element models (FEM) of the HWB multi-bay and bulkhead assembly are developed to evaluate the performance of the PRSEUS construction. In order to assess the comparative weight reduction benefits of the PRSEUS technology, conventional cylindrical skin-stringer-frame models of a cylindrical and a double-bubble section fuselage concepts are developed. Stress analysis with design cabin-pressure load and scenario based case studies are conducted for design improvement in each case. Alternate analysis with stitched composite hat-stringers and C-frames are also presented, in addition to the foam-core sandwich frame and pultruded rod-stringer construction. The FEM structural stress, strain and weights are computed and compared for relative weight/strength benefit assessment. The structural analysis and specific weight comparison of these stitched composite advanced aircraft fuselage concepts demonstrated that the pressurized HWB fuselage section assembly can be structurally as efficient as the conventional cylindrical fuselage section with composite stringer-frame and PRSEUS construction, and significantly better than the conventional aluminum construction and the double-bubble section concept.

  1. OPTIMAL AIRCRAFT TRAJECTORIES FOR SPECIFIED RANGE

    Science.gov (United States)

    Lee, H.

    1994-01-01

    cruise cost is specified, an optimum trajectory can easily be generated; however, the range obtained for a particular optimum cruise cost is not known a priori. For short range flights, the program iteratively varies the optimum cruise cost until the computed range converges to the specified range. For long-range flights, iteration is unnecessary since the specified range can be divided into a cruise segment distance and full climb and descent distances. The user must supply the program with engine fuel flow rate coefficients and an aircraft aerodynamic model. The program currently includes coefficients for the Pratt-Whitney JT8D-7 engine and an aerodynamic model for the Boeing 727. Input to the program consists of the flight range to be covered and the prevailing flight conditions including pressure, temperature, and wind profiles. Information output by the program includes: optimum cruise tables at selected weights, optimal cruise quantities as a function of cruise weight and cruise distance, climb and descent profiles, and a summary of the complete synthesized optimal trajectory. This program is written in FORTRAN IV for batch execution and has been implemented on a CDC 6000 series computer with a central memory requirement of approximately 100K (octal) of 60 bit words. This aircraft trajectory optimization program was developed in 1979.

  2. Familial Ehlers-Danlos syndrome with lethal arterial events caused by a mutation in COL5A1.

    Science.gov (United States)

    Monroe, Glen R; Harakalova, Magdalena; van der Crabben, Saskia N; Majoor-Krakauer, Danielle; Bertoli-Avella, Aida M; Moll, Frans L; Oranen, Björn I; Dooijes, Dennis; Vink, Aryan; Knoers, Nine V; Maugeri, Alessandra; Pals, Gerard; Nijman, Isaac J; van Haaften, Gijs; Baas, Annette F

    2015-06-01

    Different forms of Ehlers-Danlos syndrome (EDS) exist, with specific phenotypes and associated genes. Vascular EDS, caused by heterozygous mutations in the COL3A1 gene, is characterized by fragile vasculature with a high risk of catastrophic vascular events at a young age. Classic EDS, caused by heterozygous mutations in the COL5A1 or COL5A2 genes, is characterized by fragile, hyperextensible skin and joint laxity. To date, vessel rupture in four unrelated classic EDS patients with a confirmed COL5A1 mutation has been reported. We describe familial occurrence of a phenotype resembling vascular EDS in a mother and her two sons, who all died at an early age from arterial ruptures. Diagnostic Sanger sequencing in the proband failed to detect aberrations in COL3A1, COL1A1, COL1A2, TGFBR1, TGFBR2, SMAD3, and ACTA2. Next, the proband's DNA was analyzed using a next-generation sequencing approach targeting 554 genes linked to vascular disease (VASCULOME project). A novel heterozygous mutation in COL5A1 was detected, resulting in an essential glycine substitution at the C-terminal end of the triple helix domain (NM_000093.4:c.4610G>T; p.Gly1537Val). This mutation was also present in DNA isolated from autopsy material of the index's brother. No material was available from the mother, but the mutation was excluded in her parents, siblings and in the father of her sons, suggesting that the COL5A1 mutation occurred in the mother's genome de novo. In conclusion, we report familial occurrence of lethal arterial events caused by a COL5A1 mutation. © 2015 Wiley Periodicals, Inc.

  3. Responses of Pseudomonas putida to Zinc Excess Determined at the Proteome Level: Pathways Dependent and Independent of ColRS.

    Science.gov (United States)

    Mumm, Karl; Ainsaar, Kadi; Kasvandik, Sergo; Tenson, Tanel; Hõrak, Rita

    2016-12-02

    Zinc is an important micronutrient for bacteria, but its excess is toxic. Recently, the ColRS two-component system was shown to detect and respond to zinc excess and to contribute to zinc tolerance of Pseudomonas putida. Here, we applied a label-free whole-cell proteome analysis to compare the zinc-induced responses of P. putida and colR knockout. We identified dozens of proteins that responded to zinc in a ColR-independent manner, among others, known metal efflux systems CzcCBA1, CzcCBA2, CadA2 and CzcD. Nine proteins were affected in a ColR-dependent manner, and besides known ColR targets, four new candidates for ColR regulon were identified. Despite the relatively modest ColR-dependent changes of wild-type, colR deficiency resulted in drastic proteome alterations, with 122 proteins up- and 62 down-regulated by zinc. This zinc-promoted response had remarkable overlap with the alternative sigma factor AlgU-controlled regulon in P. aeruginosa. The most prominent hallmark was a high induction of alginate biosynthesis proteins and regulators. This response likely alleviates the zinc stress, as the AlgU-regulated alginate regulator AmrZ was shown to contribute to zinc tolerance of colR knockout. Thus, the ColRS system is important for zinc homeostasis, and in its absence, alternative stress response pathways are activated to support the zinc tolerance.

  4. Influence of the COL5A1 rs12722 on musculoskeletal injuries in professional soccer players.

    Science.gov (United States)

    Massidda, M; Bachis, V; Corrias, L; Piras, F; Scorcu, M; Calò, C M

    2015-11-01

    The aim of this study was to investigate whether COL5A1 rs12722 polymorphism is associated with musculoskeletal injuries in elite soccer players. Fifty-four male professional soccer players of European origin (25.9±4.3 years) were recruited from a team participating at the Official Italian Professional Championship during four consecutive seasons (2009-2013). The incidence and severity of musculoskeletal injuries and its relationship to COL5A1 rs12722 polymorphism were analyzed. DNA was extracted from buccal swab. The cohort was genotyped for the COL5A1 rs12722 single nucleotide polymorphism (SNP) through PCR and enzyme digestion with BstUI, and musculoskeletal injuries data were collected during the four seasons. Injuries were categorized under 5 degrees of severity based on the number of days' absence, while musculoskeletal injuries incidence was calculated per 1,000 hours of exposure to training and matches ((∑ injuries/∑ exposure hours) x 1000). No significant differences were found among genotypes for incidence of musculoskeletal injuries (P=0.683). Participants with TT genotype (3.71±0.5, N.=4) showed a trend (P=0.193) versus an higher severity of injuries than individuals with TC (2.98±0.8, N.=10) or CC (2.75±0.95, n=4) genotypes. The COL5A1 rs12722 accounted for 44% of severity of injuries (P=0.002). In conclusion, the COL5A1 rs12722 was found to be associated with severity of musculoskeletal injuries but not with incidence of musculoskeletal injuries in top-level soccer players.

  5. IDENTIFICATION OF AIRCRAFT HAZARDS

    Energy Technology Data Exchange (ETDEWEB)

    K.L. Ashley

    2005-03-23

    Aircraft hazards were determined to be potentially applicable to a repository at Yucca Mountain in the ''Monitored Geological Repository External Events Hazards Screening Analysis'' (BSC 2004, Section 6.4.1). That determination was conservatively based on limited knowledge of flight data in the area of concern and on crash data for aircraft of the type flying near Yucca Mountain. The purpose of this report is to identify specific aircraft hazards that may be applicable to a Monitored Geologic Repository (MGR) at Yucca Mountain using NUREG-0800, ''Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants'' (NRC 1987, Section 3.5.1.6), as guidance for the inclusion or exclusion of identified aircraft hazards. NUREG-0800 is being used here as a reference because some of the same considerations apply. The intended use of this report is to provide inputs for further screening and analysis of the identified aircraft hazards based on the criteria that apply to Category 1 and 2 event sequence analyses as defined in 10 CFR 63.2 (see Section 4). The scope of this technical report includes the evaluation of military, private, and commercial use of airspace in the 100-mile regional setting of the MGR at Yucca Mountain with the potential for reducing the regional setting to a more manageable size after consideration of applicable screening criteria (see Section 7).

  6. Identification of Aircraft Hazards

    International Nuclear Information System (INIS)

    K. Ashley

    2006-01-01

    Aircraft hazards were determined to be potentially applicable to a repository at Yucca Mountain in ''Monitored Geological Repository External Events Hazards Screening Analysis'' (BSC 2005 [DIRS 174235], Section 6.4.1). That determination was conservatively based upon limited knowledge of flight data in the area of concern and upon crash data for aircraft of the type flying near Yucca Mountain. The purpose of this report is to identify specific aircraft hazards that may be applicable to a monitored geologic repository (MGR) at Yucca Mountain, using NUREG-0800, ''Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants'' (NRC 1987 [DIRS 103124], Section 3.5.1.6), as guidance for the inclusion or exclusion of identified aircraft hazards. The intended use of this report is to provide inputs for further screening and analysis of identified aircraft hazards based upon the criteria that apply to Category 1 and Category 2 event sequence analyses as defined in 10 CFR 63.2 [DIRS 176544] (Section 4). The scope of this report includes the evaluation of military, private, and commercial use of airspace in the 100-mile regional setting of the repository at Yucca Mountain with the potential for reducing the regional setting to a more manageable size after consideration of applicable screening criteria (Section 7)

  7. IDENTIFICATION OF AIRCRAFT HAZARDS

    International Nuclear Information System (INIS)

    K.L. Ashley

    2005-01-01

    Aircraft hazards were determined to be potentially applicable to a repository at Yucca Mountain in the ''Monitored Geological Repository External Events Hazards Screening Analysis'' (BSC 2004, Section 6.4.1). That determination was conservatively based on limited knowledge of flight data in the area of concern and on crash data for aircraft of the type flying near Yucca Mountain. The purpose of this report is to identify specific aircraft hazards that may be applicable to a Monitored Geologic Repository (MGR) at Yucca Mountain using NUREG-0800, ''Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants'' (NRC 1987, Section 3.5.1.6), as guidance for the inclusion or exclusion of identified aircraft hazards. NUREG-0800 is being used here as a reference because some of the same considerations apply. The intended use of this report is to provide inputs for further screening and analysis of the identified aircraft hazards based on the criteria that apply to Category 1 and 2 event sequence analyses as defined in 10 CFR 63.2 (see Section 4). The scope of this technical report includes the evaluation of military, private, and commercial use of airspace in the 100-mile regional setting of the MGR at Yucca Mountain with the potential for reducing the regional setting to a more manageable size after consideration of applicable screening criteria (see Section 7)

  8. Identification of Aircraft Hazards

    Energy Technology Data Exchange (ETDEWEB)

    K. Ashley

    2006-12-08

    Aircraft hazards were determined to be potentially applicable to a repository at Yucca Mountain in ''Monitored Geological Repository External Events Hazards Screening Analysis'' (BSC 2005 [DIRS 174235], Section 6.4.1). That determination was conservatively based upon limited knowledge of flight data in the area of concern and upon crash data for aircraft of the type flying near Yucca Mountain. The purpose of this report is to identify specific aircraft hazards that may be applicable to a monitored geologic repository (MGR) at Yucca Mountain, using NUREG-0800, ''Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants'' (NRC 1987 [DIRS 103124], Section 3.5.1.6), as guidance for the inclusion or exclusion of identified aircraft hazards. The intended use of this report is to provide inputs for further screening and analysis of identified aircraft hazards based upon the criteria that apply to Category 1 and Category 2 event sequence analyses as defined in 10 CFR 63.2 [DIRS 176544] (Section 4). The scope of this report includes the evaluation of military, private, and commercial use of airspace in the 100-mile regional setting of the repository at Yucca Mountain with the potential for reducing the regional setting to a more manageable size after consideration of applicable screening criteria (Section 7).

  9. Design, analysis, and control of large transport aircraft utilizing engine thrust as a backup system for the primary flight controls

    Science.gov (United States)

    Gerren, Donna S.

    1993-01-01

    A review of accidents that involved the loss of hydraulic flight control systems serves as an introduction to this project. In each of the accidents--involving transport aircraft such as the DC-10, the C-5A, the L-1011, and the Boeing 747--the flight crew attempted to control the aircraft by means of thrust control. Although these incidents had tragic endings, in the absence of control power due to primary control system failure, control power generated by selective application of engine thrust has proven to be a viable alternative. NASA Dryden has demonstrated the feasibility of controlling an aircraft during level flight, approach, and landing conditions using an augmented throttles-only control system. This system has been successfully flown in the flight test simulator for the B-720 passenger transport and the F-15 air superiority fighter and in actual flight tests for the F-15 aircraft. The Douglas Aircraft Company is developing a similar system for the MD-11 aircraft. The project's ultimate goal is to provide data for the development of thrust control systems for mega-transports (600+ passengers).

  10. TCV software test and validation tools and technique. [Terminal Configured Vehicle program for commercial transport aircraft operation

    Science.gov (United States)

    Straeter, T. A.; Williams, J. R.

    1976-01-01

    The paper describes techniques for testing and validating software for the TCV (Terminal Configured Vehicle) program which is intended to solve problems associated with operating a commercial transport aircraft in the terminal area. The TCV research test bed is a Boeing 737 specially configured with digital computer systems to carry out automatic navigation, guidance, flight controls, and electronic displays research. The techniques developed for time and cost reduction include automatic documentation aids, an automatic software configuration, and an all software generation and validation system.

  11. Computed and Experimental Flutter/LCO Onset for the Boeing Truss-Braced Wing Wind-Tunnel Model

    Science.gov (United States)

    Bartels, Robert E.; Scott, Robert C.; Funk, Christie J.; Allen, Timothy J.; Sexton, Bradley W.

    2014-01-01

    This paper presents high fidelity Navier-Stokes simulations of the Boeing Subsonic Ultra Green Aircraft Research truss-braced wing wind-tunnel model and compares the results to linear MSC. Nastran flutter analysis and preliminary data from a recent wind-tunnel test of that model at the NASA Langley Research Center Transonic Dynamics Tunnel. The simulated conditions under consideration are zero angle of attack, so that structural nonlinearity can be neglected. It is found that, for Mach number greater than 0.78, the linear flutter analysis predicts flutter onset dynamic pressure below the wind-tunnel test and that predicted by the Navier-Stokes analysis. Furthermore, the wind-tunnel test revealed that the majority of the high structural dynamics cases were wing limit cycle oscillation (LCO) rather than flutter. Most Navier-Stokes simulated cases were also LCO rather than hard flutter. There is dip in the wind-tunnel test flutter/LCO onset in the Mach 0.76-0.80 range. Conditions tested above that Mach number exhibited no aeroelastic instability at the dynamic pressures reached in the tunnel. The linear flutter analyses do not show a flutter/LCO dip. The Navier-Stokes simulations also do not reveal a dip; however, the flutter/LCO onset is at a significantly higher dynamic pressure at Mach 0.90 than at lower Mach numbers. The Navier-Stokes simulations indicate a mild LCO onset at Mach 0.82, then a more rapidly growing instability at Mach 0.86 and 0.90. Finally, the modeling issues and their solution related to the use of a beam and pod finite element model to generate the Navier-Stokes structure mode shapes are discussed.

  12. TUMOR-SPECIFIC EXPRESSION AND ALTERNATIVE SPLICING OF THE COL6A3 GENE IN PANCREATIC CANCER

    Science.gov (United States)

    Arafat, Hwyda; Lazar, Melissa; Salem, Khalifa; Chipitsyna, Galina; Gong, Qiaoke; Pan, Te-Cheng; Zhang, Rui-Zhu; Yeo, Charles J.; Chu, Mon-Li

    2011-01-01

    Introduction Pancreatic ductal adenocarcinoma (PDA) is a highly lethal disease in which a prominent desmoplastic reaction is a defining characteristic. Fibrillar collagens, such as collagen I and to a lesser extent, collagen III and V comprise the majority of this stromal fibrosis. Type VI collagen (COL6) forms a microfibrillar network associated with type I collagen fibrils. The expression of COL6 has been linked to inflammation and survival. Importantly, tumor-specific alternative splicing in COL6A3 has been identified in several cancers by genome exon arrays. We evaluated the expression and localization of COL6A3 in PDA and premalignant lesions and explored the presence of alternative splicing events. Methods We analyzed paired PDA-normal (n=18), IPMN (n=5), pancreatic cystadenoma (n=5), and eight PDA cell lines with RT-PCR, using unique primers that identify total COL6A3 gene and alternative splicing sites in several of its exons. Western blot analysis and immunohistochemistry were used to analyze the expression levels and localization of COL6A3 protein in the different lesions, and in two animal models of PDA. Results COL6A3 protein levels were significantly upregulated in 77% of the paired PDA-adjacent tissue examined. COL6A3 was mainly present in the desmoplastic stroma of PDA, with high deposition around the malignant ducts and in between the sites of stromal fatty infiltration. Analysis of the COL6A3 splice variants showed tumor-specific consistent inclusion of exons 3 and 6 in 17 of the 18 (94%) paired PDA-adjacent tissues. Inclusion of exon 4 was exclusively tumor-specific, with barely detectable expression in the adjacent tissues. IPMN and pancreatic cystadenomas showed no expression of any of the examined exons. Total COL6A3 mRNA and exon 6 were identified in six PDA cell lines, but only two cell lines (MIA PACA-2 and ASPC-1) expressed exons 3 and 4. In both the xenograft and transgenic models of PDA, COL6A3 immunoreactivity was present in the stroma

  13. 78 FR 70848 - Special Conditions: Boeing Model 777-200, -300, and -300ER Series Airplanes; Aircraft Electronic...

    Science.gov (United States)

    2013-11-27

    ... unintentional corruption of data and systems critical to the safety and maintenance of the airplane. The... comment are unnecessary, and good cause exists for adopting these special conditions upon publication in...

  14. 78 FR 70849 - Special Conditions: Boeing Model 777-200, -300, and -300ER Series Airplanes; Aircraft Electronic...

    Science.gov (United States)

    2013-11-27

    ... unintentional corruption of data and systems critical to the safety and maintenance of the airplane. The... comment are unnecessary, and good cause exists for adopting these special conditions upon publication in...

  15. 78 FR 68986 - Special Conditions: Boeing Model 777-200, -300, and -300ER Series Airplanes; Aircraft Electronic...

    Science.gov (United States)

    2013-11-18

    ... vulnerabilities from intentional or unintentional corruption of data and systems critical to the safety and... comment are unnecessary, and good cause exists for adopting these special conditions upon publication in...

  16. Design, ancillary testing, analysis and fabrication data for the advanced composite stabilizer for Boeing 737 aircraft. Volume 1: Technical summary

    Science.gov (United States)

    Aniversario, R. B.; Harvey, S. T.; Mccarty, J. E.; Parsons, J. T.; Peterson, D. C.; Pritchett, L. D.; Wilson, D. R.; Wogulis, E. R.

    1983-01-01

    The horizontal stabilizer of the 737 transport was redesigned. Five shipsets were fabricated using composite materials. Weight reduction greater than the 20% goal was achieved. Parts and assemblies were readily produced on production-type tooling. Quality assurance methods were demonstrated. Repair methods were developed and demonstrated. Strength and stiffness analytical methods were substantiated by comparison with test results. Cost data was accumulated in a semiproduction environment. FAA certification was obtained.

  17. 75 FR 68688 - Airworthiness Directives; The Boeing Company Model 757 Airplanes

    Science.gov (United States)

    2010-11-09

    ... airplanes. This AD requires changing the lower fixed leading edge panel assemblies immediately outboard of... have drain holes and unsealed panel assemblies in the fixed leading edge adjacent to the inboard end of... Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707, MC 2H-65, Seattle...

  18. The Boeing Company Applied Academics Project Evaluation: Year Four. Evaluation Report.

    Science.gov (United States)

    Wang, Changhua; Owens, Thomas R.

    This paper describes fourth-year outcomes (1993-94) of the Boeing Company-funded Applied Academics Project. Since the 1990-91 school year, the company has provided funds to improve and expand applied academics in 60 Washington high schools. Data were collected from pre- and post-surveys of students enrolled in the project's Applied Mathematics…

  19. The Boeing Company's Manufacturing Technology Student Internship. Final Evaluation Report for 1996.

    Science.gov (United States)

    Owens, Tom

    A study evaluated The Boeing Company's Student Internship Program for students enrolled in a manufacturing technology program. The programs in the Seattle (Washington) and Portland (Oregon) areas provided students with three progressive internship levels offered in the summers of grades 11, 12, and 13 (the first year of community college). The…

  20. The Boeing Company's Manufacturing Technology Student Internship. Evaluation Report (1994-95).

    Science.gov (United States)

    Wang, Changhua; Owens, Thomas R.

    An evaluation was conducted of the Boeing Company's summer internship program for students enrolled in a manufacturing technology program after grades 11, 12, and 13 (first year of community college). The evaluation included the following activities: a review of documents describing the internship structure, student selection process, and…

  1. The trapped-particle instability in the Boeing 1kW FEL oscillator

    International Nuclear Information System (INIS)

    Ramos, L.; Blau, J.; Colson, W.B.

    1995-01-01

    The new design for the Boeing High Average Power Free Electron Laser will operate at 1KW average power (0.63 μm) with a peak current of 132A. Simulations are used to investigate the trapped-particle instability and diffraction effects. Incorporating large desynchronism may prove to be a useful method of controlling the trapped-particle instability

  2. Boeing--A Case Study Example of Enterprise Project Management from a Learning Organization Perspective.

    Science.gov (United States)

    Szymczak, Conrad C.; Walker, Derek H. T.

    2003-01-01

    The evolution of the Boeing Company illustrates how to achieve an enterprise project management culture through organizational learning. Project management can be a survival technique for adapting to change as well as a proactive mechanism. An organizational culture that supports commitment and enthusiasm and a knowledge management infrastructure…

  3. 75 FR 7557 - Airworthiness Directives; The Boeing Company Model 767 Airplanes

    Science.gov (United States)

    2010-02-22

    ... inspection of the ceiling area for any visible cosmetic and/or tie-rod chafing that could be caused by a... shorts in many systems, including the spar fuel shut off valve, oxygen mask deployment, and burned wires... causing minor cosmetic damage and tie-rod chafing. Boeing conducted a quality assurance investigation and...

  4. 75 FR 70863 - Airworthiness Directives; The Boeing Company Model 747 Airplanes

    Science.gov (United States)

    2010-11-19

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company... the electrical bond resistance between the motor operated valve (MOV) actuators and airplane structure..., without change, to http://www.regulations.gov , including any personal information you provide. We will...

  5. 76 FR 21815 - Airworthiness Directives; The Boeing Company Model 737 Airplanes

    Science.gov (United States)

    2011-04-19

    ... [email protected] ; Internet https://www.myboeingfleet.com . You may review copies of the... AD Docket You may examine the AD docket on the Internet at http://www.regulations.gov ; or in person... there is no distinction of dependence on airplane configuration for the initial compliance times. Boeing...

  6. 76 FR 68366 - Airworthiness Directives; The Boeing Company Model 777-200 and -300 Series Airplanes

    Science.gov (United States)

    2011-11-04

    ... new bonding jumpers, and measuring the resistance of the modified installation to verify resistance is... comments we receive, without change, to http://www.regulations.gov , including any personal information you... to the other end of the jumpers to the vertical stabilizer. Boeing has determined that the root cause...

  7. MODELLING OF SOME AIRCRAFT PARAMETERS

    African Journals Online (AJOL)

    . There has, therefore, been a wide range reaction against aircraft noise in particular by community residents living close to the airports. Research has, thus, been mainly on effect of aircraft noise particularly and environmental noise and ...

  8. Prohibition of Oxidizers Aboard Aircraft

    Science.gov (United States)

    1996-12-30

    RSPA proposes to amend the Hazardous Material Regulations to prohibit the carriage of oxidizers, including compressed oxygen, in passenger carrying aircraft and in Class D compartments on cargo aircraft. This proposal specifically analyzes the prohib...

  9. Safety hazard of aircraft icing

    Science.gov (United States)

    Mclean, J. C., Jr.

    1979-01-01

    The problem of aircraft icing is reported as well as the type of aircraft affected, the pilots involved, and an identification of the areas where reduction in icing accidents are readily accomplished.

  10. Composite materials for aircraft structures

    National Research Council Canada - National Science Library

    Baker, A. A; Dutton, Stuart; Kelly, Donald

    2004-01-01

    ... materials for aircraft structures / Alan Baker, Stuart Dutton, and Donald Kelly- 2nd ed. p. cm. - (Education series) Rev. ed. of: Composite materials for aircraft structures / edited by B. C. Hos...

  11. Further Evolution of Composite Doubler Aircraft Repairs Through a Focus on Niche Applications

    Energy Technology Data Exchange (ETDEWEB)

    ROACH,DENNIS P.

    2000-07-15

    The number of commercial airframes exceeding twenty years of service continues to grow. A typical aircraft can experience over 2,000 fatigue cycles (cabin pressurizations) and even greater flight hours in a single year. An unavoidable by-product of aircraft use is that crack and corrosion flaws develop throughout the aircraft's skin and substructure elements. Economic barriers to the purchase of new aircraft have created an aging aircraft fleet and placed even greater demands on efficient and safe repair methods. The use of bonded composite doublers offers the airframe manufacturers and aircraft maintenance facilities a cost effective method to safety extend the lives of their aircraft. Instead of riveting multiple steel or aluminum plates to facilitate an aircraft repair, it is now possible to bond a single Boron-Epoxy composite doubler to the damaged structure. The FAA's Airworthiness Assurance Center at Sandia National Labs (AANC) is conducting a program with Boeing and Federal Express to validate and introduce composite doubler repair technology to the US commercial aircraft industry. This project focuses on repair of DC-10 structure and builds on the foundation of the successful L-1011 door corner repair that was completed by the AANC, Lockheed-Martin, and Delta Air Lines. The L-1011 composite doubler repair was installed in 1997 and has not developed any flaws in over three years of service, As a follow-on effort, this DC-1O repair program investigated design, analysis, performance (durability, flaw containment, reliability), installation, and nondestructive inspection issues. Current activities are demonstrating regular use of composite doubler repairs on commercial aircraft. The primary goal of this program is to move the technology into niche applications and to streamline the design-to-installation process. Using the data accumulated to date, the team has designed, analyzed, and developed inspection techniques for an array of composite doubler

  12. Long Range Aircraft Trajectory Prediction

    OpenAIRE

    Magister, Tone

    2009-01-01

    The subject of the paper is the improvement of the aircraft future trajectory prediction accuracy for long-range airborne separation assurance. The strategic planning of safe aircraft flights and effective conflict avoidance tactics demand timely and accurate conflict detection based upon future four–dimensional airborne traffic situation prediction which is as accurate as each aircraft flight trajectory prediction. The improved kinematics model of aircraft relative flight considering flight ...

  13. Safety assessment of a nuclear power plant building subjected to an aircraft crash

    Energy Technology Data Exchange (ETDEWEB)

    Thai, Duc-Kien; Kim, Seung-Eock, E-mail: sekim@sejong.ac.kr

    2015-11-15

    Highlights: • Numerical analysis of a nuclear auxiliary building under aircraft crash is conducted. • The analysis result of impact force is verified using the Riera function. • The safety assessment is performed with regard to different impact scenarios. • Discussions and conclusions on safety of the nuclear building are presented. - Abstract: This paper presents a safety assessment of a nuclear building subjected to an aircraft crash using numerical analysis. For impact simulation, the reinforced concrete (RC) Primary Auxiliary Building (PAB) of the Korea Standard Nuclear Power Plant (KSNP) is fully modeled and an aircraft model of a Boeing 767-400 is used. The Riera function is used to verify the analysis result of impact force–time history. The IRIS test is used to verify the structural behavior of the RC wall under impact loading. The safety assessment of the building is performed with regard to different impact scenarios. The safety of the nuclear building under aircraft crash, including (1) global structural safety, (2) local structural safety, and (3) vibration safety are evaluated and discussed. The results show that the global and local structural safety of the PAB is ensured in all impact scenarios. However, the vibration safety of the building is not ensured. In accordance, the regulatory guide of United States Nuclear Regulatory Commission (U.S. NRC), shutdown of the nuclear power plant is required.

  14. Numerical analysis of nuclear power plant structure subjected to aircraft crash

    Science.gov (United States)

    Saberi, Reza; Alinejad, Majid; Mahdavi, Mir Omid; Sepanloo, Kamran

    2017-12-01

    An aircraft crashing into a nuclear containment may induce a series of disasters related to containment capacity, including local penetration and perforation of the containment, intensive vibrations, and fire ignited after jet fuel leakage. In this study, structural safety of a reinforced concrete containment vessel (RCCV) has been studied against the direct hit of Airbus A320, Boeing 707-320 and Phantom F4 aircrafts. ABAQUS/explicit finite element code has been used to carry out the three-dimensional numerical simulations. The impact locations identified on the nuclear containment structure are mid height of containment, center of the cylindrical portion, junction of dome and cylinder, and over the cylindrical portion close to the foundation level. The loading of the aircraft has been assigned through the corresponding reaction-time response curve. The concrete damaged plasticity model was predicted to simulate the behavior of concrete while the behavior of steel reinforcement was incorporated using elastoplastic material model. Dynamic loading conditions were considered using dynamic increase factor. The mid height of containment and center of cylindrical portion have been found to experience most severe deformation against each aircraft crash. It has also been found that compression damage in concrete is not critical at none of the impact locations.

  15. On the dominant noise components of tactical aircraft: Laboratory to full scale

    Science.gov (United States)

    Tam, Christopher K. W.; Aubert, Allan C.; Spyropoulos, John T.; Powers, Russell W.

    2018-05-01

    This paper investigates the dominant noise components of a full-scale high performance tactical aircraft. The present study uses acoustic measurements of the exhaust jet from a single General Electric F414-400 turbofan engine installed in a Boeing F/A-18E Super Hornet aircraft operating from flight idle to maximum afterburner. The full-scale measurements are to the ANSI S12.75-2012 standard employing about 200 microphones. By comparing measured noise spectra with those from hot supersonic jets observed in the laboratory, the dominant noise components specific to the F/A-18E aircraft at different operating power levels are identified. At intermediate power, it is found that the dominant noise components of an F/A-18E aircraft are essentially the same as those of high temperature supersonic laboratory jets. However, at military and afterburner powers, there are new dominant noise components. Their characteristics are then documented and analyzed. This is followed by an investigation of their origin and noise generation mechanisms.

  16. Aircraft parameter estimation

    Indian Academy of Sciences (India)

    With the evolution of high performance modern aircraft and spiraling developmental and experimental costs, the importance of flight validated databases for flight control design applications and for flight simulators has increased significantly in the recent past. Ground-based and in-flight simulators are increasingly used not ...

  17. Aircraft Capability Management

    Science.gov (United States)

    Mumaw, Randy; Feary, Mike

    2018-01-01

    This presentation presents an overview of work performed at NASA Ames Research Center in 2017. The work concerns the analysis of current aircraft system management displays, and the initial development of an interface for providing information about aircraft system status. The new interface proposes a shift away from current aircraft system alerting interfaces that report the status of physical components, and towards displaying the implications of degradations on mission capability. The proposed interface describes these component failures in terms of operational consequences of aircraft system degradations. The research activity was an effort to examine the utility of different representations of complex systems and operating environments to support real-time decision making of off-nominal situations. A specific focus was to develop representations that provide better integrated information to allow pilots to more easily reason about the operational consequences of the off-nominal situations. The work is also seen as a pathway to autonomy, as information is integrated and understood in a form that automated responses could be developed for the off-nominal situations in the future.

  18. 2001 Industry Studies: Aircraft

    Science.gov (United States)

    2001-01-01

    period following deregulation, the average number of seats per airplane-mile in all but the transpacific market went down. Even with the Pacific...timely fashion, aircraft will be grounded upon delivery and future sales will be in jeopardy. 13 Despite the problems encountered during the development of

  19. Aircraft Lightning Protection Handbook

    Science.gov (United States)

    1989-09-01

    of the Streamers may propagate onward from two or oncoming leader, more extremities of the aircraft at the same time. If ncnesw" Omw so, the incoming...however, come in two broad cat- is so small that such a spark would leave little or no egories based on their distillation temperature ranges; other

  20. COL1A1 and COL1A2 sequencing results in cohort of patients undergoing evaluation for potential child abuse.

    Science.gov (United States)

    Zarate, Yuri A; Clingenpeel, Rachel; Sellars, Elizabeth A; Tang, Xinyu; Kaylor, Julie A; Bosanko, Katherine; Linam, Leann E; Byers, Peter H

    2016-07-01

    Child abuse is a major public health concern that can explain a proportion of fractures in children. Osteogenesis imperfecta (OI) is the most common inherited syndrome that predisposes to skeletal fractures. We conducted a retrospective analysis of data from clinical, laboratory, and radiographic information from children evaluated for child abuse in which molecular testing for COL1A1 and COL1A2 genes was conducted. A total of 43 patients underwent molecular testing for OI. Pathogenic variants predicted to result in a mild form of OI were found in two patients (5%), both clinically suspected to have this diagnosis. None of the cases in whom OI molecular testing was ordered when maltreatment concerns were thought to be more likely (0/35) were identified to have pathogenic variants. After reviewing each individual case, the final diagnosis was child abuse for 34 cases (77%), and additional radiographic and laboratory studies did not identify any with inherited metabolic predisposition to fracture or rickets. We conclude that routine testing for OI in the setting of child abuse when no other suggestive clinical findings are present has a low yield. A careful review of the medical history and a detailed clinical evaluation help identify those at risk for genetic alterations. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  1. Bone mineral properties in growing Col1a2(+/G610C) mice, an animal model of osteogenesis imperfecta.

    Science.gov (United States)

    Masci, Marco; Wang, Min; Imbert, Laurianne; Barnes, Aileen M; Spevak, Lyudmila; Lukashova, Lyudmila; Huang, Yihe; Ma, Yan; Marini, Joan C; Jacobsen, Christina M; Warman, Matthew L; Boskey, Adele L

    2016-06-01

    The Col1a2(+/G610C) knock-in mouse, models osteogenesis imperfecta in a large old order Amish family (OOA) with type IV OI, caused by a G-to-T transversion at nucleotide 2098, which alters the gly-610 codon in the triple-helical domain of the α2(I) chain of type I collagen. Mineral and matrix properties of the long bones and vertebrae of male Col1a2(+/G610C) and their wild-type controls (Col1a2(+/+)), were characterized to gain insight into the role of α2-chain collagen mutations in mineralization. Additionally, we examined the rescuability of the composition by sclerostin inhibition initiated by crossing Col1a2(+/G610C) with an LRP(+/A214V) high bone mass allele. At age 10-days, vertebrae and tibia showed few alterations by micro-CT or Fourier transform infrared imaging (FTIRI). At 2-months-of-age, Col1a2(+/G610C) tibias had 13% fewer secondary trabeculae than Col1a2(+/+), these were thinner (11%) and more widely spaced (20%) than those of Col1a2(+/+) mice. Vertebrae of Col1a2(+/G610C) mice at 2-months also had lower bone volume fraction (38%), trabecular number (13%), thickness (13%) and connectivity density (32%) compared to Col1(a2+/+). The cortical bone of Col1a2(+/G610C) tibias at 2-months had 3% higher tissue mineral density compared to Col1a2(+/+); Col1a2(+/G610C) vertebrae had lower cortical thickness (29%), bone area (37%) and polar moment of inertia (38%) relative to Col1a2(+/+). FTIRI analysis, which provides information on bone chemical composition at ~7μm-spatial resolution, showed tibias at 10-days did not differ between genotypes. Comparing identical bone types in Col1a2(+/G610C) to Col1a2(+/+) at 2-months-of-age, tibias showed higher mineral-to-matrix ratio in trabeculae (17%) and cortices (31%). and in vertebral cortices (28%). Collagen maturity was 42% higher at 10-days-of-age in Col1a2(+/G610C) vertebral trabeculae and in 2-month tibial cortices (12%), vertebral trabeculae (42%) and vertebral cortices (12%). Higher acid-phosphate substitution

  2. High Himalayan meteorology: Weather at the South Col of Mount Everest

    Science.gov (United States)

    Moore, G. W. K.; Semple, John L.

    2004-09-01

    Mount Everest is often referred to as the earth's `third' pole. As such it is relatively inaccessible and little is known about its meteorology. In 1998, a portable weather station was operated at the mountain's South Col, elevation 7,986 m. We believe that this represents the highest elevation at which continuous weather data has ever been collected and thus represents a valuable dataset with which to investigate the meteorology of the high Himalaya. In this paper, we compare the observations with reanalyses from the National Centers for Environmental Prediction and the European Center for Medium-Range Weather Forecasts. We find that both reanalyses capture much of the synoptic-scale variability in the temperature and pressure at the South Col site, especially in the pre-monsoon season. Furthermore, we show that an observed weather event was the result of convection associated with a jet streak and an intrusion of stratospheric air into the upper-troposphere.

  3. A Colônia do Sacramento, o "Jardim da América"

    OpenAIRE

    Possomai, Paulo César

    2004-01-01

    A semelhança entre o clima da Colônia do Sacramento e o de Portugal levou vários cronistas a retratar os arredores da fortaleza como um jardim europeu. Entretan­to, o desenvolvimento agrícola em Sacramento não foi espontâneo, mas fruto da ação do governador, que proibiu a caça ao gado selvagem, principal recurso econômico da região, aos colonos que não cultivassem seus lotes. The resemblance between the climate of the Colônia do Sacramento and that of Portugal led many chroniclers to portr...

  4. Mutation-based growth charts for SEDC and other COL2A1 related dysplasias

    DEFF Research Database (Denmark)

    Terhal, Paulien A; van Dommelen, Paula; Le Merrer, Martine

    2012-01-01

    From data collected via a large international collaborative study, we have constructed a growth chart for patients with molecularly confirmed congenital spondylo-epiphyseal dysplasia (SEDC) and other COL2A1 related dysplasias. The growth chart is based on longitudinal height measurements of 79...... patients with glycine substitutions in the triple-helical domain of COL2A1. In addition, measurements of 27 patients with other molecular defects, such as arginine to cysteine substitutions, splice mutations, and mutations in the C-terminal propeptide have been plotted on the chart. Height of the patients...... progressively deviate from that of normal children: compared to normal WHO charts, the mean length/height is -2.6 SD at birth, -4.2 SD at 5 years, and -5.8 SD in adulthood. The mean adult height (male and female combined) of patients with glycine substitutions in the triple-helical region is 138.2 cm...

  5. Geografia Rural das Novas Colônias do Alto Uruguai

    Directory of Open Access Journals (Sweden)

    Raymond Pébayle

    2014-05-01

    Full Text Available Versa sobre a geografia rural das Novas Colônis do Alto Uruguai. Artigo publicado no Boulletin de L'Association de Géographes Français nº 350-351, janeiro-fevereiro de 1967. Artigo dividido em: Paisagens rurais e sistemas de cultura; Uma sociedade rural em crise; O pêso de um isolamento. Trad.: Gilberto Lazare Rocha

  6. The following problem is from the Math Olympiad col-lection [1 ...

    Indian Academy of Sciences (India)

    The following problem is from the Math Olympiad col- lection [1]. Problem A In a chess board with 64 squares, if a set ... identified by S == {1,2,. ,k},k::; 00. Let P == ((Pij)) be a stochastic matrix, i.e., i) for each i, j, .... for all y in B(:co~/'), Now use the connectedness of S to conclude that for any Yo in S, Yo -1= ;1'0 there is a finite.

  7. Colômbia 2010: Guerra, Paz e Eleições

    Directory of Open Access Journals (Sweden)

    Luiz Antônio Gusmão

    2009-02-01

    Full Text Available

    O enfraquecimento das Farc deve polarizar as

    eleições de 2010 na Colômbia entre recrudescimento

    do combate e abertura à negociação.

  8. Vaporized Hydrogen Peroxide (VHP) Decontamination of a Section of a Boeing 747 Cabin

    National Research Council Canada - National Science Library

    Shaffstall, Robert M; Garner, Robert P; Bishop, Joshua; Cameron-Landis, Lora; Eddington, Donald L; Hau, Gwen; Spera, Shawn; Mielnik, Thaddeus; Thomas, James A

    2006-01-01

    The use of STERIS Corporation's Vaporized Hydrogen Peroxide (VHP)* technology as a potential biocide for aircraft decontamination was demonstrated in a cabin section of the Aircraft Environment Research Facility...

  9. El rol del professor en l’aprenentatge col·laboratiu mediat per ordinador

    Directory of Open Access Journals (Sweden)

    Ingrid Noguera-Fructuoso

    2009-10-01

    Full Text Available En aquest article es presenten els resultats d'una investigació sobre el canvi de rol que es produeix en el professorat en l'ús de les TIC com a eina per a l'aprenentatge col·laboratiu en educació primària i secundària. L'interès es focalitza en l'ús concret d'una eina dissenyada per a l'aprenentatge col·laboratiu, el BSCL, sota el model pedagògic de qüestionament progressiu. En primer lloc, es duu a terme una revisió teòrica. En segon lloc, s'exposen les preguntes d'investigació, la justificació d'aquesta, es descriu el disseny i l'enfocament metodològic escollit, l'estudi de casos. Els resultats obtinguts revelen que hi ha una tendència cap al canvi de rol en el professorat en l'ús del BSCL com a eina per a l'aprenentatge col·laboratiu així com l'eficàcia del model de qüestionament progressiu en la construcció de coneixement de l'alumnat.

  10. Stimulation of Escherichia coli F-18Col- Type-1 fimbriae synthesis by leuX

    DEFF Research Database (Denmark)

    Newman, Joseph V.; Burghoff, Robert L.; Pallesen, Lars

    1994-01-01

    Escherichia coli F-18, a normal human fecal isolate, is an excellent colonizer of the streptomycin-treated mouse large intestine. E. coli F-18Col-, a derivative of E. coli F-18 which no longer makes the E. coli F-18 colicin, colonizes the large intestine as well as E. coli F-18 when fed to mice...... alone but is eliminated when fed together with E. coli F-18. Recently we randomly cloned E. coli F-18 DNA into E. coli F-18Col- and let the mouse intestine select the best colonizer. In this way, we isolated a 6.5-kb E. coli F-18 DNA sequence that simultaneously stimulated synthesis of type 1 fimbriae...... and enhanced E. coli F-18Col- colonizing ability. In the present investigation we show that the gene responsible for stimulation of type 1 fimbriae synthesis appears to be leuX, which encodes a tRNA specific for the rare leucine codon UUG. Moreover, it appears that expression of leuX may be regulated by two...

  11. Noise Scaling and Community Noise Metrics for the Hybrid Wing Body Aircraft

    Science.gov (United States)

    Burley, Casey L.; Brooks, Thomas F.; Hutcheson, Florence V.; Doty, Michael J.; Lopes, Leonard V.; Nickol, Craig L.; Vicroy, Dan D.; Pope, D. Stuart

    2014-01-01

    An aircraft system noise assessment was performed for the hybrid wing body aircraft concept, known as the N2A-EXTE. This assessment is a result of an effort by NASA to explore a realistic HWB design that has the potential to substantially reduce noise and fuel burn. Under contract to NASA, Boeing designed the aircraft using practical aircraft design princip0les with incorporation of noise technologies projected to be available in the 2020 timeframe. NASA tested 5.8% scale-mode of the design in the NASA Langley 14- by 22-Foot Subsonic Tunnel to provide source noise directivity and installation effects for aircraft engine and airframe configurations. Analysis permitted direct scaling of the model-scale jet, airframe, and engine shielding effect measurements to full-scale. Use of these in combination with ANOPP predictions enabled computations of the cumulative (CUM) noise margins relative to FAA Stage 4 limits. The CUM margins were computed for a baseline N2A-EXTE configuration and for configurations with added noise reduction strategies. The strategies include reduced approach speed, over-the-rotor line and soft-vane fan technologies, vertical tail placement and orientation, and modified landing gear designs with fairings. Combining the inherent HWB engine shielding by the airframe with added noise technologies, the cumulative noise was assessed at 38.7 dB below FAA Stage 4 certification level, just 3.3 dB short of the NASA N+2 goal of 42 dB. This new result shows that the NASA N+2 goal is approachable and that significant reduction in overall aircraft noise is possible through configurations with noise reduction technologies and operational changes.

  12. Collision With Trees on Final Approach Federal Express Flight 1478 Boeing 727-232, N497FE, Tallahassee, Florida

    National Research Council Canada - National Science Library

    2002-01-01

    This report explains the accident involving Federal Express flight 1478, a Boeing 727-232F, N497FE, which struck trees on short final approach and crashed short of runway 9 at the Tallahassee Regional...

  13. Effects of reinforcement ratio and arrangement on the structural behavior of a nuclear building under aircraft impact

    International Nuclear Information System (INIS)

    Thai, Duc-Kien; Kim, Seung-Eock; Lee, Hyuk-Kee

    2014-01-01

    Highlights: • Numerical analysis of RC nuclear building model under aircraft impact was conducted. • The analysis result shows similar behavior as compared to the Riera function. • The effects of reinforcement ratio and arrangement were enumerated. • The appropriate number of layer of longitudinal rebar was recommended. - Abstract: This study presents the effectiveness of the rebar ratio and the arrangement of reinforced concrete (RC) structures on the structural behavior of nuclear buildings under aircraft impact using a finite element (FE) approach. A simplified model of a fictitious nuclear building using RC structures was fully modeled. The aircraft model of a Boeing 767-400 was used for impact simulation and was developed and verified with a conventional impact force–time history curve. The IRIS Punching test was used to validate the damage prediction capabilities of the RC wall under impact loading. With regard to the different rebar ratios and rebar arrangements of a nuclear RC building, the structural behavior of a building under aircraft impact was investigated. The structural behavior investigated included plastic deformation, displacement, energy dissipation, perforation/penetration depth and scabbing area. The results showed that the rebar ratio has a significant effect on withstanding aircraft impact and reducing local damage. With four layers of rebar, the RC wall absorbed and dissipated the impact energy more than once with only two layers of rebar for the same rebar ratio

  14. Plan, formulate, discuss and correlate a NASTRAN finite element vibrations model of the Boeing Model 360 helicopter airframe

    Science.gov (United States)

    Gabel, R.; Lang, P. F.; Smith, L. A.; Reed, D. A.

    1989-01-01

    Boeing Helicopter, together with other United States helicopter manufacturers, participated in a finite element applications program to emplace in the United States a superior capability to utilize finite element analysis models in support of helicopter airframe design. The activities relating to planning and creating a finite element vibrations model of the Boeing Model 36-0 composite airframe are summarized, along with the subsequent analytical correlation with ground shake test data.

  15. Volume da gota dos colírios lubrificantes: estudo farmacoeconômico

    Directory of Open Access Journals (Sweden)

    Alexandre Xavier da Costa

    2015-12-01

    Full Text Available RESUMO Objetivo: Determinar o volume médio das gotas produzidas pelos colírios lubrificantes em diferentes ângulos de inclinação e determinar o custo médio do tratamento. Métodos: Determinação do volume da gota de 3 frascos originais dos colírios lubrificantes Artelac®, Hylo Comod®, Lacrima® Plus, Systane® UL, Lacrifilm®, Hyabak®, Lacribell®, Ecofilm®, Mirugell®, Plenigell®, Fresh Tears®, Optive® e Endura® à inclinação de 90º e 45º. Determinou-se o número médio de gotas em cada frasco e foi feita avaliação farmacoeconômica dos colírios. Resultados: O volume das gotas variou de 32,2 a 64,0 µL a 45o e de 29,1 a 65,1 µL a 90o. A diferença entre as gotas em cada inclinação foi de 2 a 24% e o custo anual dos colírios de acordo com a inclinação variou de R$2,73 a R$130,73. A Duração Máxima de Tratamento (DMT foi de 29,3 a 51,4 dias na inclinação de 45o, e de 28,8 a 48,4 dias a 90º, sendo que a diferença na DMT foi de 0,5 até 8 dias a mais ou a menos, de acordo com a marca. Conclusão: Nenhum dos colírios estudados apresentou gotas ideais para o olho humano, levando a um desperdício do produto e maior custo para o fabricante e para o consumidor. Percebemos que existe uma variação significativa no volume da gota de acordo com a inclinação do frasco, e que uma variação maior do que 10% traria impactos financeiros para o paciente.

  16. : Le cancer du col de l'utérus, nouvelles stratégies de dépistage ?

    OpenAIRE

    Heard , Isabelle; Costagliola , Dominique

    2008-01-01

    National audience; Le cancer du col de l'utérus reste le deuxième cancer le plus fréquent chez les femmes dans le monde, alors que son dépistage, par le frottis, existe depuis plus de 50 ans. En France, le cancer du col de l'utérus est le huitième cancer féminin avec 3 387 nouveaux cas estimés en 2000

  17. Entomopathogenic fungi in predatory beetles (Col: Carabidae and Staphylinidae) from agricultural fields

    DEFF Research Database (Denmark)

    Steenberg, T; Langer, V; Esbjerg, P

    1995-01-01

    Prevalence of entomopathogenic fungi was studied in overwintering ground beetles (Col.: Carabidae) and rove beetles (Col.: Staphylinidae) collected from fields of lucerne, white cabbage and white cabbage undersown with white clover. In general infection levels in adult ground beetles and rove...... angustatus. Beauveria bassiana was the predominant fungus isolated from ground beetles and rove beetles from all studied sites. Other fungal species included the hyphomycetes Metarhizium anisopliae, Paecilomyces farinosus and Verticillium lecanii as well as Zoophthora radicans and Zoophthora philonthi...

  18. Aircraft engine pollution reduction.

    Science.gov (United States)

    Rudey, R. A.

    1972-01-01

    The effect of engine operation on the types and levels of the major aircraft engine pollutants is described and the major factors governing the formation of these pollutants during the burning of hydrocarbon fuel are discussed. Methods which are being explored to reduce these pollutants are discussed and their application to several experimental research programs are pointed out. Results showing significant reductions in the levels of carbon monoxide, unburned hydrocarbons, and oxides of nitrogen obtained from experimental combustion research programs are presented and discussed to point out potential application to aircraft engines. An experimental program designed to develop and demonstrate these and other advanced, low pollution combustor design methods is described. Results that have been obtained to date indicate considerable promise for reducing advanced engine exhaust pollutants to levels significantly below current engines.

  19. CHROMagar COL-APSE: a selective bacterial culture medium for the isolation and differentiation of colistin-resistant Gram-negative pathogens.

    Science.gov (United States)

    Abdul Momin, Muhd Haziq F; Bean, David C; Hendriksen, Rene S; Haenni, Marisa; Phee, Lynette M; Wareham, David W

    2017-11-01

    A selective chromogenic culture medium for the laboratory isolation and differentiation of colistin resistant Acinetobacter, Pseudomonas, Stenotrophomonas and Enterobacteriaceae spp. (CHROMagar COL-APSE) was developed, evaluated and compared to an existing selective bacterial culture medium (SuperPolymyxin). The medium was challenged with 84 isolates, including polymyxin B (POL B)-susceptible and -resistant type strains and colistin (COL)-resistant organisms recovered from human and animal samples. Susceptibility to COL and POL B was determined by agar dilution and broth microtitre dilution. The lower limit for the detection of COL-resistant organisms was also calculated for both CHROMagar COL-APSE and SuperPolymyxin media. The ability to isolate and correctly differentiate COL-resistant organisms within mixed cultures was also assessed and compared using both media. Using CHROMagar COL-APSE, Gram-negative pathogens (n=71) with intrinsic (n=8) or acquired COL (n=63) resistance were recovered with 100 % specificity down to the lower limit of detection of 10 1 colony-forming units (c.f.u.). The growth on SuperPolymyxin was similar, but notably weaker for COL-resistant non-fermentative bacteria (Acinetobacter, Pseudomonas and Stenotrophomonas). CHROMagar COL-APSE was also more sensitive in supporting the growth of Enterobacteriaceae with COL resistance associated with the carriage of mcr-1. CHROMagar COL-APSE is a sensitive and specific medium for the growth of COL-resistant bacterial pathogens. Due to the low limit of detection (10 1  c.f.u.), it may be useful as a primary isolation medium in the surveillance and recovery of COL-resistant bacteria from complex human, veterinary and environmental samples, especially those with plasmid-mediated MCR-1 or novel mechanisms of polymyxin resistance.

  20. Aircraft EMP Isolation Study.

    Science.gov (United States)

    1980-07-01

    technology are to be seen in the insulated column structures of modern Van de Graaff accelerators. These columns are plane assemblies of glass or...reviewed by the Public Affairs Office and is releasable to the National Technical Information Service (NTIS). At NTIS, it will be available to the general ...the aircraft tail and the high-energy, high-voltage impulse generator . 23 The recommended means of isolation consist of: (1) short dielectric columns on

  1. Ehlers-Danlos syndrome type IV is associated with a novel G984R COL3A1 mutation.

    Science.gov (United States)

    Deng, Yao; Wei, Shijie; Hu, Shijun; Chen, Jinlan; Tan, Zhiping; Yang, Yifeng

    2015-07-01

    Ehlers-Danlos syndrome type IV is an autosomal dominant connective tissue disease. Mutations in COL3A1 have been identified to underlie this disease; however, to the best of our knowledge, no COL3A1 mutations have been reported in Ehlers-Danlos syndrome type IV patients with an ascending aortic aneurysm. In order to develop further understanding of COL3A1 mutations, an Ehlers-Danlos syndrome type IV patient diagnosed with an ascending aortic aneurysm and a familial history of sudden mortality was analyzed. Genomic DNA was isolated from the peripheral blood of the patient and his family members. All coding exons of eight aneurysm-related genes (FBN1, TGFBR1, TGFBR 2, MYH11, ACTA2, SLC2A10, NOTCH1 and COL3A1) were amplified using polymerase chain reaction (PCR). The PCR products were sequenced with the ABI 3100 Genetic Analyzer, and a mutation was predicted and identified using Polyphen-2, SIFT and Mutation Taster. The novel mutation was identified as c.2950G>A in COL3A1, which results in p.G984R. All three programs predicted this mutation to be deleterous to the protein function. The novel mutation identified in this study is potentially responsible for Ehlers-Danlos syndrome type IV in this patient, and expands the spectrum of COL3A1 mutations.

  2. Aircraft specific exhaust emissions

    Energy Technology Data Exchange (ETDEWEB)

    Lecht, M.; Deidewig, F.; Doepelheuer, A. [Deutsche Forschungsanstalt fuer Luft- und Raumfahrt e.V. (DLR), Koeln (Germany). Inst. fuer Antriebstechnik

    1997-12-01

    The objective of this work to calculate essential species of aircraft emissions has been approached by a combination of different tasks. First of all engine performance and emission correlation has been modelled taking sea level static measurements from the engine certification process as a reference. At second a flight simulation program has been modified to couple aircraft and engine performance along a flight mission profile. By this for a selected number of aircraft/engine combinations the emissions of NO{sub x}, CO and HC as well as fuel burn for short, medium and long haul flights have been calculated and finally adapted to a specified format of flight distance and altitude increments. Sensitivity studies of the change of emissions along the cruise section showed a 30% decrease of the NO{sub x} emission rate until the end of cruise. Differences of ambient air temperature from ISA conditions will have a substantial impact on NO{sub x}, CO and HC emissions rather than on mission fuel. (orig.) 144 figs., 42 tabs., 497 refs.

  3. Management strategies in the aerospace industry. Particular case: The Boeing Company

    Directory of Open Access Journals (Sweden)

    Daniela MOCENCO

    2015-03-01

    Full Text Available The present paper aims to provide an overview of the aviation industry in the United States (US. The study focuses on Boeing Company analyzing the organizational architecture and management strategies applied throughout its evolution. The paper is structured in three parts: the first part presents the scientific references; part two focuses on the structure, management strategies and performances of the company; the last part is devoted to conclusions

  4. Salapärane Boeing tõi Eestisse konteinereid / Ester Vilgats

    Index Scriptorium Estoniae

    Vilgats, Ester

    2005-01-01

    Ilmunud ka: Pärnu Postimees 8. nov., lk. 3, Postimees : na russkom jazõke 10. nov. lk. 10. Pärnu lennujaama juhataja Erki Teemägi ja Kaitsepolitsei Pärnu osakonna politseidirektor Kalev Kont kinnitasid, et Pärnu lennuväljal 12. jaanuaril 2003. aastal maandunud Boeing 737 vedas kaubakonteinereid, mitte terroristidest sõjavange, nagu väitis ajaleht Washington Post. Vt. samas: Neeme Raud. Inimõiguslased ootavad euroliidu sekkumist

  5. Dual-band infrared imaging for quantitative corrosion detection in aging aircraft

    Energy Technology Data Exchange (ETDEWEB)

    Del Grande, N.K.

    1993-11-01

    Aircraft skin thickness-loss from corrosion has been measured using dual-band infrared (DBIR) imaging on a flash-heated Boeing 737 fuselage structure. We mapped surface temperature differences of 0.2 to 0.6 {degrees}C for 5 to 14% thickness losses within corroded lap splices at 0.4 seconds after the heat flash. Our procedure mapped surface temperature differences at sites without surface-emissivity clutter (from dirt, dents, tape, markings, ink, sealants, uneven paint, paint stripper, exposed metal and roughness variations). We established the correlation of percent thickness loss with surface temperature rise using a partially corroded F-18 wing box and several aluminum panels which had thickness losses from milled flat-bottom holes. We mapped the lap splice composite thermal inertia, (kpc){sup {1/2}}, which characterized shallow skin defects within the lap splice at early times (<0.3 s) and deeper skin defects within the lap splice at late times (>0.4 s). Corrosion invaded the inside of the Boeing 737 lap splice, beneath the galley and the latrine, where we observed ``pillowing`` from volume build-up of corrosion by-products.

  6. Dual-band infrared imaging for quantitative corrosion detection in aging aircraft

    Energy Technology Data Exchange (ETDEWEB)

    Del Grande, N.K. [Lawrence Livermore National Lab., CA (United States)

    1993-12-31

    Aircraft skin thickness-loss from corrosion has been measured using dual-band infrared (DBIR) imaging on a flash-heated Boeing 737 fuselage structure. The authors mapped surface temperature differences of 0.2 to 0.6 C for 5 to 14 % thickness losses within corroded lap splices at 0.4 seconds after the heat flash. The procedure mapped surface temperature differences at sites without surface-emissivity clutter (from dirt, dents, tape, markings, ink, sealants, uneven paint, paint stripper, exposed metal and roughness variations). They established the correlation of percent thickness loss with surface temperature rise using a partially corroded F-18 wing box and several aluminum panels which had thickness losses from milled flat-bottom holes. The authors mapped the lap splice composite thermal inertia, (k{rho}c){sup 1/2}, which characterized shallow skin defects within the lap splice at early times (<0.3 s) and deeper skin defects within the lap splice at late times (>0.4 s). Corrosion invaded the inside of the Boeing 737 lap splice, beneath the galley and the latrine, where they observed ``pillowing`` from volume build-up of corrosion by-products.

  7. Aircraft cockpit vision: Math model

    Science.gov (United States)

    Bashir, J.; Singh, R. P.

    1975-01-01

    A mathematical model was developed to describe the field of vision of a pilot seated in an aircraft. Given the position and orientation of the aircraft, along with the geometrical configuration of its windows, and the location of an object, the model determines whether the object would be within the pilot's external vision envelope provided by the aircraft's windows. The computer program using this model was implemented and is described.

  8. Homozygosity and Heterozygosity for Null Col5a2 Alleles Produce Embryonic Lethality and a Novel Classic Ehlers-Danlos Syndrome-Related Phenotype.

    Science.gov (United States)

    Park, Arick C; Phillips, Charlotte L; Pfeiffer, Ferris M; Roenneburg, Drew A; Kernien, John F; Adams, Sheila M; Davidson, Jeffrey M; Birk, David E; Greenspan, Daniel S

    2015-07-01

    Null alleles for the COL5A1 gene and missense mutations for COL5A1 or the COL5A2 gene underlie cases of classic Ehlers-Danlos syndrome, characterized by fragile, hyperextensible skin and hypermobile joints. However, no classic Ehlers-Danlos syndrome case has yet been associated with COL5A2 null alleles, and phenotypes that might result from such alleles are unknown. We describe mice with null alleles for the Col5a2. Col5a2(-/-) homozygosity is embryonic lethal at approximately 12 days post conception. Unlike previously described mice null for Col5a1, which die at 10.5 days post conception and virtually lack collagen fibrils, Col5a2(-/-) embryos have readily detectable collagen fibrils, thicker than in wild-type controls. Differences in Col5a2(-/-) and Col5a1(-/-) fibril formation and embryonic survival suggest that α1(V)3 homotrimers, a rare collagen V isoform that occurs in the absence of sufficient levels of α2(V) chains, serve functional roles that partially compensate for loss of the most common collagen V isoform. Col5a2(+/-) adults have skin with marked hyperextensibility and reduced tensile strength at high strain but not at low strain. Col5a2(+/-) adults also have aortas with increased compliance and reduced tensile strength. Results thus suggest that COL5A2(+/-) humans, although unlikely to present with frank classic Ehlers-Danlos syndrome, are likely to have fragile connective tissues with increased susceptibility to trauma and certain chronic pathologic conditions. Copyright © 2015 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  9. Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects.

    Directory of Open Access Journals (Sweden)

    Tamar R Grossman

    2011-11-01

    Full Text Available A significant current challenge in human genetics is the identification of interacting genetic loci mediating complex polygenic disorders. One of the best characterized polygenic diseases is Down syndrome (DS, which results from an extra copy of part or all of chromosome 21. A short interval near the distal tip of chromosome 21 contributes to congenital heart defects (CHD, and a variety of indirect genetic evidence suggests that multiple candidate genes in this region may contribute to this phenotype. We devised a tiered genetic approach to identify interacting CHD candidate genes. We first used the well vetted Drosophila heart as an assay to identify interacting CHD candidate genes by expressing them alone and in all possible pairwise combinations and testing for effects on rhythmicity or heart failure following stress. This comprehensive analysis identified DSCAM and COL6A2 as the most strongly interacting pair of genes. We then over-expressed these two genes alone or in combination in the mouse heart. While over-expression of either gene alone did not affect viability and had little or no effect on heart physiology or morphology, co-expression of the two genes resulted in ≈50% mortality and severe physiological and morphological defects, including atrial septal defects and cardiac hypertrophy. Cooperative interactions between DSCAM and COL6A2 were also observed in the H9C2 cardiac cell line and transcriptional analysis of this interaction points to genes involved in adhesion and cardiac hypertrophy. Our success in defining a cooperative interaction between DSCAM and COL6A2 suggests that the multi-tiered genetic approach we have taken involving human mapping data, comprehensive combinatorial screening in Drosophila, and validation in vivo in mice and in mammalian cells lines should be applicable to identifying specific loci mediating a broad variety of other polygenic disorders.

  10. Studying Impact Damage on Carbon-Fiber Reinforced Aircraft Composite Panels with Sonicir

    Science.gov (United States)

    Han, Xiaoyan; Zhao, Xinyue; Zhang, Ding; He, Qi; Song, Yuyang; Lubowicki, Anthony; Newaz, Golam.; Favro, Lawrence D.; Thomas, Robert L.

    2011-06-01

    Composites are becoming more important materials in commercial aircraft structures such as the fuselage and wings with the new B787 Dreamliner from Boeing which has the target to utilize 50% by weight of composite materials. Carbon-fiber reinforced composites are the material of choice in aircraft structures. This is due to their light weight and high strength (high strength-to-weight ratio), high specific stiffness, tailorability of properties, design flexibility etc. Especially, by reducing the aircraft's body weight by using such lighter structures, the cost of fuel can be greatly reduced with the high jet fuel price for commercial airlines. However, these composites are prone to impact damage and the damage may occur without any observable sign on the surface, yet resulting in delaminations and disbonds that may occur well within the layers. We are studying the impact problem with carbon-fiber reinforced composite panels and developing SonicIR for this application as a fast and wide-area NDE technology. In this paper, we present our results in studying composite structures including carbon-fiber reinforced composite materials, and preliminary quantitative studies on delamination type defect depth identification in the panels.

  11. Modeling of aircraft exhaust emissions and infrared spectra for remote measurement of nitrogen oxides

    Directory of Open Access Journals (Sweden)

    K. Beier

    Full Text Available Infrared (IR molecular spectroscopy is proposed to perform remote measurements of NOx concentrations in the exhaust plume and wake of aircraft. The computer model NIRATAM is applied to simulate the physical and chemical properties of the exhaust plume and to generate low resolution IR spectra and synthetical thermal images of the aircraft in its natural surroundings. High-resolution IR spectra of the plume, including atmospheric absorption and emission, are simulated using the molecular line-by-line radiation model FASCODE2. Simulated IR spectra of a Boeing 747-400 at cruising altitude for different axial and radial positions in the jet region of the exhaust plume are presented. A number of spectral lines of NO can be identified that can be discriminated from lines of other exhaust gases and the natural atmospheric background in the region around 5.2 µm. These lines can be used to determine NO concentration profiles in the plume. The possibility of measuring nitrogen dioxide NO2 is also discussed briefly, although measurements turn out to be substantially less likely than those of NO. This feasibility study compiles fundamental data for the optical and radiometric design of an airborne Fourier transform spectrometer and the preparation of in-flight measurements for monitoring of aircraft pollutants.

  12. Modeling of aircraft exhaust emissions and infrared spectra for remote measurement of nitrogen oxides

    Directory of Open Access Journals (Sweden)

    K. Beier

    1994-08-01

    Full Text Available Infrared (IR molecular spectroscopy is proposed to perform remote measurements of NOx concentrations in the exhaust plume and wake of aircraft. The computer model NIRATAM is applied to simulate the physical and chemical properties of the exhaust plume and to generate low resolution IR spectra and synthetical thermal images of the aircraft in its natural surroundings. High-resolution IR spectra of the plume, including atmospheric absorption and emission, are simulated using the molecular line-by-line radiation model FASCODE2. Simulated IR spectra of a Boeing 747-400 at cruising altitude for different axial and radial positions in the jet region of the exhaust plume are presented. A number of spectral lines of NO can be identified that can be discriminated from lines of other exhaust gases and the natural atmospheric background in the region around 5.2 µm. These lines can be used to determine NO concentration profiles in the plume. The possibility of measuring nitrogen dioxide NO2 is also discussed briefly, although measurements turn out to be substantially less likely than those of NO. This feasibility study compiles fundamental data for the optical and radiometric design of an airborne Fourier transform spectrometer and the preparation of in-flight measurements for monitoring of aircraft pollutants.

  13. Studying impact damage on carbon-fiber reinforced aircraft composite panels with sonicir

    International Nuclear Information System (INIS)

    Han Xiaoyan; Zhang Ding; He Qi; Song Yuyang; Lubowicki, Anthony; Zhao Xinyue; Newaz, Golam.; Favro, Lawrence D.; Thomas, Robert L.

    2011-01-01

    Composites are becoming more important materials in commercial aircraft structures such as the fuselage and wings with the new B787 Dreamliner from Boeing which has the target to utilize 50% by weight of composite materials. Carbon-fiber reinforced composites are the material of choice in aircraft structures. This is due to their light weight and high strength (high strength-to-weight ratio), high specific stiffness, tailorability of properties, design flexibility etc. Especially, by reducing the aircraft's body weight by using such lighter structures, the cost of fuel can be greatly reduced with the high jet fuel price for commercial airlines. However, these composites are prone to impact damage and the damage may occur without any observable sign on the surface, yet resulting in delaminations and disbonds that may occur well within the layers. We are studying the impact problem with carbon-fiber reinforced composite panels and developing SonicIR for this application as a fast and wide-area NDE technology. In this paper, we present our results in studying composite structures including carbon-fiber reinforced composite materials, and preliminary quantitative studies on delamination type defect depth identification in the panels.

  14. Chemistry in aircraft plumes

    Energy Technology Data Exchange (ETDEWEB)

    Kraabol, A.G.; Stordal, F.; Knudsen, S. [Norwegian Inst. for Air Research, Kjeller (Norway); Konopka, P. [Deutsche Forschungsanstalt fuer Luft- und Raumfahrt e.V. (DLR), Wessling (Germany). Inst. fuer Physik der Atmosphaere

    1997-12-31

    An expanding plume model with chemistry has been used to study the chemical conversion of NO{sub x} to reservoir species in aircraft plumes. The heterogeneous conversion of N{sub 2}O{sub 5} to HNO{sub 3}(s) has been investigated when the emissions take place during night-time. The plume from an B747 has been simulated. During a ten-hour calculation the most important reservoir species was HNO{sub 3} for emissions at noon. The heterogeneous reactions had little impact on the chemical loss of NO{sub x} to reservoir species for emissions at night. (author) 4 refs.

  15. Hydrogen aircraft technology

    Science.gov (United States)

    Brewer, G. D.

    1991-01-01

    A comprehensive evaluation is conducted of the technology development status, economics, commercial feasibility, and infrastructural requirements of LH2-fueled aircraft, with additional consideration of hydrogen production, liquefaction, and cryostorage methods. Attention is given to the effects of LH2 fuel cryotank accommodation on the configurations of prospective commercial transports and military airlifters, SSTs, and HSTs, as well as to the use of the plentiful heatsink capacity of LH2 for innovative propulsion cycles' performance maximization. State-of-the-art materials and structural design principles for integral cryotank implementation are noted, as are airport requirements and safety and environmental considerations.

  16. Commercial Aircraft Protection

    Energy Technology Data Exchange (ETDEWEB)

    Ehst, David A. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-10-26

    This report summarizes the results of theoretical research performed during 3 years of P371 Project implementation. In results of such research a new scientific conceptual technology of quasi-passive individual infrared protection of heat-generating objects – Spatial Displacement of Thermal Image (SDTI technology) was developed. Theoretical substantiation and description of working processes of civil aircraft individual IR-protection system were conducted. The mathematical models and methodology were presented, there were obtained the analytical dependencies which allow performing theoretical research of the affect of intentionally arranged dynamic field of the artificial thermal interferences with variable contrast onto main parameters of optic-electronic tracking and homing systems.

  17. Exclusion of COL2A1 and VDR as Developmental Dysplasia of the Hip Genes

    OpenAIRE

    Rubini, Michele; Cavallaro, Alessandra; Calzolari, Elisa; Bighetti, Giulia; Sollazzo, Vincenzo

    2008-01-01

    Developmental dysplasia of the hip (DDH) is a spectrum of disorders affecting the proximal femur and/or acetabulum leading to an abnormal formation of the hip. Genetic factors are involved in the etiology of DDH. Early recognition of DDH affords the best results from treatment and a better knowledge of the genetics of DDH could enhance early diagnosis. Variants in the Type II collagen (COL2A1) and vitamin D receptor (VDR) genes have been associated with patients with osteoarthritis of the hip...

  18. La Wiki com a suport del treball col·laboratiu, setembre 2012

    OpenAIRE

    Deumal López, Glòria; Gil García, Enric

    2012-01-01

    Què és una wiki?, com s'estructura una wiki, com construir col·laborativament una wiki, com iniciar-se personalment en l'edició d'una wiki i exemples. ¿Qué es una wiki?, cómo se estructura una wiki, cómo construir colaborativamente una wiki, cómo iniciarse personalmente en la edición de una wiki y ejemplos. What is a wiki?, How to structure a wiki, how to collaboratively build a wiki, how to start editing a wiki and examples.

  19. Colágeno asimilable. Fuente de prevención de enfermedades osteoarticuladas

    OpenAIRE

    Parra Parra, Yolanda; Quesada Martínez, María Inmaculada; Pérez Collado, Elisa María

    2015-01-01

    Cartel presentado en la Segunda Conferencia Internacional de Comunicación en Salud, celebrada el 23 de octubre de 2015 en la Universidad Carlos III de Madrid Introducción: El colágeno es la proteína más abundante de nuestro cuerpo humano y uno de sus componentes esencial de articulaciones, cartílago, ligamento, tendones, huesos, piel. Su especial estructura lo hacen único, presenta una estructura fibrosa, que aporta gran resistencia y flexibilidad a los tejidos de los que forma parte. Cu...

  20. Identification and characterization of the human type II collagen gene (COL2A1).

    OpenAIRE

    Cheah, Kathryn; Stoker, N.G.; Griffin, J.R.; Grosveld, Frank; Solomon, E.

    1985-01-01

    textabstractThe gene contained in the human cosmid clone CosHcol1, previously designated an alpha 1(I) collagen-like gene, has now been identified. CosHcol1 hybridizes strongly to a single 5.9-kilobase mRNA species present only in tissue in which type II collagen is expressed. DNA sequence analysis shows that this clone is highly homologous to the chicken alpha 1(II) collagen gene. These data together suggest that CosHcol1 contains the human alpha 1(II) collagen gene COL2A1. The clone appears...

  1. A crise Armada Colômbia-Equador no contexto da Guerra contra o Terrorismo Internacional

    Directory of Open Access Journals (Sweden)

    TATIANA WAISBERG

    2010-10-01

    Full Text Available A recente crise armada entre Colômbia e Equador trouxe a América do Sul ao foco da mídia internacional. As FARC representam o maior barril de pólvora da América Latina, além de um determinante ator a ser combatido na luta contra o terrorismo internacional. Nesse sentido, o presente artigo busca analisar, sob o prisma da segurança e do direito internacional o papel das FARC em âmbito global e as maneiras segundo as quais elas são combatidas.

  2. X-38 vehicle #131R arrives at NASA Dryden via NASA'S Super Guppy transport aircraft

    Science.gov (United States)

    2000-01-01

    NASA's Super Guppy transport aircraft landed at Edwards Air Force Base, Calif. on July 11, 2000, to deliver the latest version of the X-38 drop vehicle to Dryden. The X-38s are intended as prototypes for a possible 'crew lifeboat' for the International Space Station. The X-38 vehicle 131R will demonstrate a huge 7,500 square-foot parafoil that will that will enable the potential crew return vehicle to land on the length of a football field after returning from space. The crew return vehicle is intended to serve as a possible emergency transport to carry a crew to safety in the event of problems with the International Space Station. The Super Guppy evolved from the 1960s-vintage Pregnant Guppy, used for transporting outsized sections of the Apollo moon rocket. The Super Guppy was modified from 1950s-vintage Boeing C-97. NASA acquired its Super Guppy from the European Space Agency in 1997.

  3. Aviation industry-research in aircraft finance

    OpenAIRE

    Ehrenthal, Joachim C.F.

    2010-01-01

    Aircraft values are key to aircraft financing decisions: Aircraft values act as a source of security for providers of debt capital and lessors failing to re-place aircraft, and as a source of upside potential to equity investors. Yet, aircraft values cannot be precisely and continuously monitored. This is because neither actual primary nor secondary aircraft transaction prices are disclosed. Various types of third party valuation estimates exist, but relying solely on third party appraisa...

  4. ERGONOMIC DESIGN OF AIRCRAFT COCKPIT

    Directory of Open Access Journals (Sweden)

    CÎMPIAN Ionuţ

    2012-09-01

    Full Text Available This paper presents a model for an ergonomic design of an aircraft cockpit with the specification and verification with respect to the new European Aviation Safety Agency (EASA and Federal Aviation Administration (FAA requirements. The goal is to expressing the concepts on which the aircraft cockpit design are based.

  5. ERGONOMIC DESIGN OF AIRCRAFT COCKPIT

    Directory of Open Access Journals (Sweden)

    CÎMPIAN Ionuţ

    2011-06-01

    Full Text Available This paper presents a model for an ergonomic design of an aircraft cockpit with the specification and verification with respect to the new European Aviation Safety Agency (EASA and Federal Aviation Administration (FAA requirements. The goal is to expressing the concepts on which the aircraft cockpit design is based.

  6. SUPPLY CHAIN FEATURES OF THE AEROSPACE INDUSTRY PARTICULAR CASE AIRBUS AND BOEING

    OpenAIRE

    Daniela MOCENCO

    2015-01-01

    Aerospace sector is one of the most globalized industries in terms of market structure and production system. Through aircraft development programs aviation industry has introduced new solutions to develop its products. The role of the partners involved in the development programs for the new generation aircraft is becoming increasingly important. Supply chain management has become a key factor for major manufacturers in the industry. The new strategies introduced by the aircraft manufacturer...

  7. Loss of Col3a1, the gene for Ehlers-Danlos syndrome type IV, results in neocortical dyslamination.

    Directory of Open Access Journals (Sweden)

    Sung-Jin Jeong

    Full Text Available It has recently been discovered that Collagen III, the encoded protein of the type IV Ehlers-Danlos Syndrome (EDS gene, is one of the major constituents of the pial basement membrane (BM and serves as the ligand for GPR56. Mutations in GPR56 cause a severe human brain malformation called bilateral frontoparietal polymicrogyria, in which neurons transmigrate through the BM causing severe mental retardation and frequent seizures. To further characterize the brain phenotype of Col3a1 knockout mice, we performed a detailed histological analysis. We observed a cobblestone-like cortical malformation, with BM breakdown and marginal zone heterotopias in Col3a1⁻/⁻ mouse brains. Surprisingly, the pial BM appeared intact at early stages of development but starting as early as embryonic day (E 11.5, prominent BM defects were observed and accompanied by neuronal overmigration. Although collagen III is expressed in meningeal fibroblasts (MFs, Col3a1⁻/⁻ MFs present no obvious defects. Furthermore, the expression and posttranslational modification of α-dystroglycan was undisturbed in Col3a1⁻/⁻ mice. Based on the previous finding that mutations in COL3A1 cause type IV EDS, our study indicates a possible common pathological pathway linking connective tissue diseases and brain malformations.

  8. Aircraft agility maneuvers

    Science.gov (United States)

    Cliff, Eugene M.; Thompson, Brian G.

    1992-01-01

    A new dynamic model for aircraft motions is presented. This model can be viewed as intermediate between a point-mass model, in which the body attitude angles are control-like, and a rigid-body model, in which the body-attitude angles evolve according to Newton's Laws. Specifically, consideration is given to the case of symmetric flight, and a model is constructed in which the body roll-rate and the body pitch-rate are the controls. In terms of this body-rate model a minimum-time heading change maneuver is formulated. When the bounds on the body-rates are large the results are similar to the point-mass model in that the model can very quickly change the applied forces and produce an acceleration to turn the vehicle. With finite bounds on these rates, the forces change in a smooth way. This leads to a measurable effect of agility.

  9. Commercial aircraft composite technology

    CERN Document Server

    Breuer, Ulf Paul

    2016-01-01

    This book is based on lectures held at the faculty of mechanical engineering at the Technical University of Kaiserslautern. The focus is on the central theme of societies overall aircraft requirements to specific material requirements and highlights the most important advantages and challenges of carbon fiber reinforced plastics (CFRP) compared to conventional materials. As it is fundamental to decide on the right material at the right place early on the main activities and milestones of the development and certification process and the systematic of defining clear requirements are discussed. The process of material qualification - verifying material requirements is explained in detail. All state-of-the-art composite manufacturing technologies are described, including changes and complemented by examples, and their improvement potential for future applications is discussed. Tangible case studies of high lift and wing structures emphasize the specific advantages and challenges of composite technology. Finally,...

  10. 1,25-Dihydroxyvitamin D3 inhibition of col1a1 promoter expression in calvariae from neonatal transgenic mice

    Science.gov (United States)

    Bedalov, A.; Salvatori, R.; Dodig, M.; Kapural, B.; Pavlin, D.; Kream, B. E.; Clark, S. H.; Woody, C. O.; Rowe, D. W.; Lichtler, A. C.

    1998-01-01

    We studied the effect of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on organ cultures of transgenic mouse calvariae containing segments of the Col1a1 promoter extending to -3518, -2297, -1997, -1794, -1763, and -1719 bp upstream of the transcription start site fused to the chloramphenicol acetyltransferase (CAT) reporter gene. 1,25(OH)2D3 had a dose-dependent inhibitory effect on the expression of the -3518 bp promoter construct (ColCAT3.6), with maximal inhibition of about 50% at 10 nM. This level of inhibition was consistent with the previously observed effect on the endogenous Col1a1 gene in bone cell models. All of the shorter constructs were also inhibited by 10 nM 1,25(OH)2D3, suggesting that the sequences required for 1, 25(OH)2D3 inhibition are downstream of -1719 bp. The inhibitory effect of 1,25(OH)2D3 on transgene mRNA was maintained in the presence of the protein synthesis inhibitor cycloheximide, suggesting that the inhibitory effect on Col1a1 gene transcription does not require de novo protein synthesis. We also examined the in vivo effect of 1,25(OH)2D3 treatment of transgenic mice on ColCAT activity, and found that 48 h treatment caused a dose-dependent inhibition of CAT activity in calvariae comparable to that observed in organ cultures. In conclusion, we demonstrated that 1,25(OH)2D3 inhibits Col1A1 promoter activity in transgenic mouse calvariae, both in vivo and in vitro. The results indicate that there is a 1, 25(OH)2D3 responsive element downstream of -1719 bp. The inhibitory effect does not require new protein synthesis.

  11. Stickler syndrome caused by COL2A1 mutations: genotype-phenotype correlation in a series of 100 patients

    DEFF Research Database (Denmark)

    Hoornaert, Kristien P; Vereecke, Inge; Dewinter, Chantal

    2010-01-01

    Stickler syndrome is an autosomal dominant connective tissue disorder caused by mutations in different collagen genes. The aim of our study was to define more precisely the phenotype and genotype of Stickler syndrome type 1 by investigating a large series of patients with a heterozygous mutation...... in COL2A1. In 188 probands with the clinical diagnosis of Stickler syndrome, the COL2A1 gene was analyzed by either a mutation scanning technique or bidirectional fluorescent DNA sequencing. The effect of splice site alterations was investigated by analyzing mRNA. Multiplex ligation...... with Stickler syndrome....

  12. Influence of Machine-Derived Smoke Yields on Biomarker of Exposure (BOE Levels in Cigarette Smokers*

    Directory of Open Access Journals (Sweden)

    Scherer Gerhard

    2015-01-01

    Full Text Available Individual uptake of tobacco smoke constituents by smoking is highly variable in cigarette smokers and cannot be predicted by smoking behaviour variables and machine-derived smoke yields. It is well established that uptake of smoke constituents is best described by a series of bio-markers of exposure (BOEs such as metabolites of nico-tine, tobacco-specific nitrosamines (TSNAs, polycyclic aromatic hydrocarbons (PAHs, aromatic amines, benzene, 1,3-butadiene, acrolein, hydrogen cyanide, 2,5-dimethyl-furan and other smoke constituents.

  13. A Boeing Delta II rocket with boosters mated sits at LP17A, CCAS

    Science.gov (United States)

    1999-01-01

    At Pad 17A, Cape Canaveral Air Station, a Boeing Delta II rocket waits with its four solid rocket boosters for final preparations to launch the Stardust satellite on Feb. 6, 1999. The rocket will carry Stardust into space for a close encounter with the comet Wild 2 in January 2004. Using a medium called aerogel, Stardust will capture comet particles flying off the nucleus of the comet, plus collect interstellar dust for later analysis. The collected samples will return to Earth in a Sample Return Capsule to be jettisoned as Stardust swings by Earth in January 2006.

  14. A History of Full-Scale Aircraft and Rotorcraft Crash Testing and Simulation at NASA Langley Research Center

    Science.gov (United States)

    Jackson, Karen E.; Boitnott, Richard L.; Fasanella, Edwin L.; Jones, Lisa E.; Lyle, Karen H.

    2004-01-01

    This paper summarizes 2-1/2 decades of full-scale aircraft and rotorcraft crash testing performed at the Impact Dynamics Research Facility (IDRF) located at NASA Langley Research Center in Hampton, Virginia. The IDRF is a 240-ft.-high steel gantry that was built originally as a lunar landing simulator facility in the early 1960's. It was converted into a full-scale crash test facility for light aircraft and rotorcraft in the early 1970 s. Since the first full-scale crash test was preformed in February 1974, the IDRF has been used to conduct: 41 full-scale crash tests of General Aviation (GA) aircraft including landmark studies to establish baseline crash performance data for metallic and composite GA aircraft; 11 full-scale crash tests of helicopters including crash qualification tests of the Bell and Sikorsky Advanced Composite Airframe Program (ACAP) prototypes; 48 Wire Strike Protection System (WSPS) qualification tests of Army helicopters; 3 vertical drop tests of Boeing 707 transport aircraft fuselage sections; and, 60+ crash tests of the F-111 crew escape module. For some of these tests, nonlinear transient dynamic codes were utilized to simulate the impact response of the airframe. These simulations were performed to evaluate the capabilities of the analytical tools, as well as to validate the models through test-analysis correlation. In September 2003, NASA Langley closed the IDRF facility and plans are underway to demolish it in 2007. Consequently, it is important to document the contributions made to improve the crashworthiness of light aircraft and rotorcraft achieved through full-scale crash testing and simulation at the IDRF.

  15. 40 CFR 87.6 - Aircraft safety.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Aircraft safety. 87.6 Section 87.6... POLLUTION FROM AIRCRAFT AND AIRCRAFT ENGINES General Provisions § 87.6 Aircraft safety. The provisions of... met within the specified time without creating a safety hazard. ...

  16. Recerca de la imatge social del col·lectiu gitano

    OpenAIRE

    Sagué Rustell, Laia

    2013-01-01

    D’ençà de la invasió de l’Islam a l’Índia, del segle XIII fins a l’actualitat, el poble rom ha patit discriminacions i persecucions de tot tipus. En uns inicis, per l’esclavitud del segle XIV fins als skin-heads i altres formes racistes d’avui en dia, passant per l’Holocaust nazi del segle XX, on es calcula que van morir entre un 70 i un 80 per cent de la població gitana. En aquest article el que es vol és contrastar la imatge social que té la població del col·lectiu romanó amb la imatge q...

  17. An integrated DEA-COLS-SFA algorithm for optimization and policy making of electricity distribution units

    International Nuclear Information System (INIS)

    Azadeh, A.; Ghaderi, S.F.; Omrani, H.; Eivazy, H.

    2009-01-01

    This paper presents an integrated data envelopment analysis (DEA)-corrected ordinary least squares (COLS)-stochastic frontier analysis (SFA)-principal component analysis (PCA)-numerical taxonomy (NT) algorithm for performance assessment, optimization and policy making of electricity distribution units. Previous studies have generally used input-output DEA models for benchmarking and evaluation of electricity distribution units. However, this study proposes an integrated flexible approach to measure the rank and choose the best version of the DEA method for optimization and policy making purposes. It covers both static and dynamic aspects of information environment due to involvement of SFA which is finally compared with the best DEA model through the Spearman correlation technique. The integrated approach would yield in improved ranking and optimization of electricity distribution systems. To illustrate the usability and reliability of the proposed algorithm, 38 electricity distribution units in Iran have been considered, ranked and optimized by the proposed algorithm of this study.

  18. Management of choledochal cyst Tratamento do cisto de colédoco

    Directory of Open Access Journals (Sweden)

    Orlando Jorge Martins Torres

    2007-09-01

    Full Text Available BACKGROUND: Choledochal cysts are rare diseases in adults. The risk of malignant transformation is well documented to be age-related and early complete cyst excision is currently advocated. Type IVa cyst management is more controversial. Extensive intrahepatic involvement of the biliary system may preclude complete excision. AIM: The aim of this study was to present a case of type IVa choledochal cyst in a young female patient. CASE REPORT: An 18-year-old female, complaining of right upper quadrant pain, nausea, vomiting, fever, and jaundice was admitted. The diagnosis of type IVa choledochal cyst was made by computerized tomography. The patient was underwent cholecystectomy, excision of the anterior wall of the cyst, and Roux-en-Y hepaticojejunostomy. No postoperative complication was noted and the patient was discharged five days after operation. CONCLUSION: Total cyst excision is the ideal treatment of choledochal cysts in adults. However, in IVa type, due to the extensive intrahepatic involvement of the biliary system, the anatomy of the cyst, and the surgeon's judgment will determine the surgical approach taken for the patient.RACIONAL: A doença de cistos de colédoco em adultos é rara. O risco de transformação maligna é bem documentado, sendo relacionado a idade, além da completa excisão do cisto ser aconselhada. O manuseio e gestão do cisto tipo IVa gera maior controvérsia. O envolvimento intra-hepático extensivo do sistema biliar pode prevenir a sua completa excisão. OBJETIVOS: Relatar o caso de um cisto de colédoco do tipo IVa em paciente feminina. RELATO DE CASO: Paciente feminina, 18 anos de idade, foi admitida com queixa de dor no quadrante superior direito, náusea, vômitos, febre e icterícia. O diagnóstico de cisto de colédoco do tipo IVa foi realizado através de tomografia computadorizada. A paciente foi submetida à colecistectomia, excisão da parede anterior do cisto e hepatojejunostomia em Y-de-Roux. Nenhuma

  19. A new simulation model for assessing aircraft emergency evacuation considering passenger physical characteristics

    International Nuclear Information System (INIS)

    Liu, Yu; Wang, Weijie; Huang, Hong-Zhong; Li, Yanfeng; Yang, Yuanjian

    2014-01-01

    Conducting a real aircraft evacuation trial is oftentimes unaffordable as it is extremely expensive and may cause severe injury to participants. Simulation models as an alternative have been used to overcome the aforementioned issues in recent years. This paper proposes a new simulation model for emergency evacuation of civil aircraft. Its unique features and advantages over the existing models are twofold: (1) passengers' critical physical characteristics, e.g. waist size, gender, age, and disabilities, which impact the movement and egress time of individual evacuee from a statistical viewpoint, are taken into account in the new model. (2) Improvements are made to enhance the accuracy of the simulation model from three aspects. First, the staggered mesh discretization method together with the agent-based approach is utilized to simulate movements of individual passengers in an emergency evacuation process. Second, each node discretized to represent cabin space in the new model can contain more than one passenger if they are moving in the same direction. Finally, each individual passenger is able to change his/her evacuation route in a real-time manner based upon the distance from the current position to the target exit and the queue length. The effectiveness of the proposed simulation model is demonstrated on Boeing 767-300 aircraft. - Highlights: • A new simulation model of aircraft emergency evacuation is developed. • Some critical physical characteristics of passengers', e.g. waist size, gender, age, and disabilities, are taken into account in the new model. • An agent-based approach along with a multi-level fine network representation is used. • Passengers are able to change their evacuation routes in a real-time manner based upon distance and length of queue

  20. Aerothermodynamics of aircraft engine components

    National Research Council Canada - National Science Library

    Oates, Gordon C

    1985-01-01

    ....A45A37 1985 ISBN 0-915928-97-3 2. Aircraft gas turbines. 629.134'353 85-13355 Copyright © 1985 by the American Institute of Aeronautics and Astronautics, Inc. All rights reserved. Printed in the ...

  1. Western Pacific Typhoon Aircraft Fixes

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Western Pacific typhoon aircraft reconnaissance data from the years 1946 - 1965 and 1978, excluding 1952, were transcribed from original documents, or copy of...

  2. Aircraft Evaluation Using Stochastic Duels

    Science.gov (United States)

    2017-09-01

    LEFT BLANK xix EXECUTIVE SUMMARY In this thesis, we present a modeling paradigm for evaluating fighter aircraft using stochastic duels... EVALUATION USING STOCHASTIC DUELS by Jason W.C. Gay September 2017 Thesis Advisor: Moshe Kress Co-Advisor: Michael Atkinson Second Reader...DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE AIRCRAFT EVALUATION USING STOCHASTIC DUELS 6. AUTHOR(S) Jason W.C. Gay 7. PERFORMING

  3. Aircraft ditching loads simulation tool

    OpenAIRE

    Bonanni, A.; Vandewaeter, L.; Havill, C.; Kanyoo, P.; Taunton, D.J.; Blake, J.I.R.; Cropper, E.; Hancock, S.

    2015-01-01

    The present work presents a novel methodology developed for calculating the steady loads acting on aircraft structures in the event of ditching in water. It represents the preliminary result of Stirling Dynamics as part of a NATEP research project. The overall objective of the project is to expand the capabilities of the Stirling Dynamics proprietary software SD-GLOAD (originally designed for ground and crash loads dynamic simulations) to aircraft ditching simulations. The methodology present...

  4. Neural networks for aircraft control

    Science.gov (United States)

    Linse, Dennis

    1990-01-01

    Current research in Artificial Neural Networks indicates that networks offer some potential advantages in adaptation and fault tolerance. This research is directed at determining the possible applicability of neural networks to aircraft control. The first application will be to aircraft trim. Neural network node characteristics, network topology and operation, neural network learning and example histories using neighboring optimal control with a neural net are discussed.

  5. Commercial transport aircraft composite structures

    Science.gov (United States)

    Mccarty, J. E.

    1983-01-01

    The role that analysis plays in the development, production, and substantiation of aircraft structures is discussed. The types, elements, and applications of failure that are used and needed; the current application of analysis methods to commercial aircraft advanced composite structures, along with a projection of future needs; and some personal thoughts on analysis development goals and the elements of an approach to analysis development are discussed.

  6. Advanced technology composite aircraft structures

    Science.gov (United States)

    Ilcewicz, Larry B.; Walker, Thomas H.

    1991-01-01

    Work performed during the 25th month on NAS1-18889, Advanced Technology Composite Aircraft Structures, is summarized. The main objective of this program is to develop an integrated technology and demonstrate a confidence level that permits the cost- and weight-effective use of advanced composite materials in primary structures of future aircraft with the emphasis on pressurized fuselages. The period from 1-31 May 1991 is covered.

  7. A very mild form of non-Herlitz junctional epidermolysis bullosa : BP180 rescue by outsplicing of mutated exon 30 coding for the COL15 domain

    NARCIS (Netherlands)

    Pasmooij, AMG; van Zalen, S; Nijenhuis, AM; Kloosterhuis, AJ; Zuiderveen, J; Jonkman, MF; Pas, HH

    Mutations in the gene COL17A1 cause non-Herlitz junctional epidermolysis bullosa. Here, we describe a patient who, despite two heterozygous mutations in COL17A1, has an extremely mild form of the disease missing most of the characteristic clinical features. DNA analysis revealed a frame-shift

  8. A founder synonymous COL7A1 mutation in three Danish families with dominant dystrophic epidermolysis bullosa pruriginosa identifies exonic regulatory sequences required for exon 87 splicing

    DEFF Research Database (Denmark)

    Covaciu, C; Grosso, F; Pisaneschi, E

    2011-01-01

    shoulders. DEB-Pr is caused by either dominant (DDEB-Pr) or recessive mutations in the COL7A1 gene encoding type VII collagen (COLVII). The full spectrum of COL7A1 mutations in DEB-Pr remains elusive and the genotype-phenotype correlation is largely incomplete. Here, we report and functionally characterize...

  9. Negative Staining for COL4A5 Correlates With Worse Prognosis and More Severe Ultrastructural Alterations in Males With Alport Syndrome

    Directory of Open Access Journals (Sweden)

    Samar M. Said

    2017-01-01

    Discussion: Thus, the COL4A5 expression pattern has an important prognostic value and it correlates with the severity of ultrastructural glomerular basement membrane alterations in males with AS. Loss of COL4A5 staining is uncommon in patients with AS diagnosed in their adulthood.

  10. Automated Aircraft Icing Forecast Technique.

    Science.gov (United States)

    1984-05-31

    an Air Weather Service detachment forecaster. Many thanks are due to Lt Col Robert G. Feddes who alerted me to this opportunity to automate and test...Safety Board, Washington, DC, Report No. NTSB-SR-81-1, 16 pp. Feddes, Robert G., 1974: A Synoptic-Scale Model for Simulating Condensed Atmospheric...AFOSR/TR-80/1279, 9pp. Hobbs, P. V., T. J. Matejka, P. H. Herzegh, J. D. Locatelli, and R. A. Houze , Jr., 1980b: The Mesoscale and Microscale

  11. Asymptomatic parental mosaicism for osteogenesis imperfect associated with a new splice site mutation in COL1A2

    DEFF Research Database (Denmark)

    Frederiksen, Anja Lisbeth; Dunø, Morten; Johnsen, Iben Birgit Gade

    2016-01-01

    Recurrent lethal perinatal osteogenesis imperfecta may result from asymptomatic parental mosaicism. A previously unreported mutation in COL1A2 leads to recurrent cases of fetal osteogenesis imperfecta Sillence type IIA, which emphasizes the importance of clinical and genetic evaluation of mosaicism...

  12. SSCP and segregation analysis of the human type X collagen gene (COL10A1) in heritable forms of chondrodysplasia

    Energy Technology Data Exchange (ETDEWEB)

    Sweetman, W.A.; Rash, B.; Thomas, J.T.; Boot-Handford, R.; Grant, M.E.; Wallis, G.A. (Univ. of Manchester (United Kingdom)); Sykes, B. (Univ. of Oxford (United Kingdom)); Beighton, P. (Univ. of Cape Town (South Africa)); Hecht, J.T. (Univ. of Texas, Houston, TX (United States)); Zabell, B. (Johannes Gutenburg Universitaet, Mainz (Germany))

    1992-10-01

    Type X collagen is a homotrimeric, short chain, nonfibrillar collagen that is expressed exclusively by hypertrophic chondrocytes at the sites of endochondral ossification. The distribution and pattern of expression of the type X collagen gene (COL10A1) suggests that mutations altering the structure and synthesis of the protein may be responsible for causing heritable forms of chondrodysplasia. The authors investigated whether mutations within the human COL10A1 gene were responsible for causing the disorders achondroplasia, hypochondroplasia, pseudoachondroplasia, and thanatophoric dysplasia, by analyzing the coding regions of the gene by using PCR and the single-stranded conformational polymorphism technique. By this approach, seven sequence changes were identified within and flanking the coding regions of the gene of the affected persons. The authors demonstrated that six of these sequence changes were not responsible for causing these forms of chondrodysplasia but were polymorphic in nature. The sequence changes were used to demonstrate discordant segregation between the COL10A1 locus and achondroplasia and pseudoachondroplasia, in nuclear families. This lack of segregation suggests that mutations within or near the COL101A1 locus are not responsible for these disorders. The seventh sequence change resulted in a valine-to-methionine substitution in the carboxyl-terminal domain of the molecule and was identified in only two hypochondroplasic individuals from a single family. Segregation analysis in this family was inconclusive, and the significance of this substitution remains uncertain. 47 refs., 3 figs., 2 tabs.

  13. Linkage analysis in a family with Stickler syndrome leads to the exclusion of the COL2A1 locus

    Energy Technology Data Exchange (ETDEWEB)

    Mottes, M.; Zolezzi, F.; Pignatti, P.F. [Univ. of Verona (Italy)

    1994-09-01

    Hereditary arthro-ophtalmopathy (AO) or Stickler Syndrome (MIM No. 10830) is a dominantly inherited disorder characterized by vitro-retinal degeneration and other connective tissue disturbances. Mutations in the COL2A1 gene, coding for type II collagen chains, have been described in a few patients. The wide spectrum of clinical manifestations is presumably due to genetic heterogeneity, since only about 50% of the Stickler families so far studied show cosegregation of the disease with the COL2A1 locus. We have investigated a large pedigree (19 individuals of whom 9 are affected) in which severe myopia with vitro-retinal degeneration consegregated with joint laxity, recurrent inguinal hernias, and degenerative changes of the hip and the knee. The 3{prime} end COL2A1 VNTR polymorphism was utilized for linkage analysis. In order to get the maximum informativity, we have analyzed the allelic microheterogeneity of this VNTR, due to the repeat sequence variation, by means of a single strand polymorphism. Mendelian inheritance of the different single strands was observed as expected. Discordance of segregation between the disease and the COL2A1 locus was thus established inequivocally in this family.

  14. Detection of mutations in the COL4A5 gene by SSCP in X-linked Alport syndrome

    DEFF Research Database (Denmark)

    Hertz, Jens Michael; Juncker, I; Persson, U

    2001-01-01

    of type IV-collagen. We performed mutation analysis of the COL4A5 gene by PCR-SSCP analysis of each of the 51 exons with flanking intronic sequences in 81 patients suspected of X-linked Alport syndrome including 29 clear X-linked cases, 37 cases from families with a pedigree compatible with X...

  15. MLPA and cDNA analysis improves COL4A5 mutation detection in X-linked Alport syndrome

    DEFF Research Database (Denmark)

    Hertz, JM; Juncker, I; Marcussen, N

    2008-01-01

    for 10-15% of mutations. We have established a method for mutation analysis of COL4A5 based on reverse transcriptase-polymerase chain reaction analysis of mRNA from cultured skin fibroblasts and multiplex ligation-dependent probe amplification (MLPA) on genomic DNA. One advantage of using skin biopsies...

  16. Molecular characterization of CONSTANS-Like (COL) genes in banana (Musa acuminata L. AAA Group, cv. Grand Nain).

    Science.gov (United States)

    Chaurasia, Akhilesh Kumar; Patil, Hemant Bhagwan; Azeez, Abdul; Subramaniam, Vadakanthara Ramakrishnan; Krishna, Bal; Sane, Aniruddha Prafullachandra; Sane, Prafullachandra Vishnu

    2016-01-01

    The CONSTANS (CO) family is an important regulator of flowering in photoperiod sensitive plants. But information regarding their role in day neutral plants is limited. We report identification of nine Group I type CONSTANS-like (COL) genes of banana and their characterization for their age dependent, diurnal and tissue-specific expression. Our studies show that the Group I genes are conserved in structure to members in other plants. Expression of these genes shows a distinct circadian regulation with a peak during light period. Developmental stage specific expression reveals high level transcript accumulation of two genes, MaCOL3a and MaCOL3b, well before flowering and until the initiation of flowering. A decrease in their transcript levels after initiation of flowering is followed by an increase in transcription of other members that coincides with the continued development of the inflorescence and fruiting. CO binding cis-elements are observed in at least three FT -like genes in banana suggesting possible CO-FT interactions that might regulate flowering. Distinct tissue specific expression patterns are observed for different family members in mature leaves, apical inflorescence, bracts, fruit skin and fruit pulp suggesting possible roles other than flowering. This is the first exhaustive study of the COL genes belonging to Group I of banana.

  17. Dramatic response after functional hemispherectomy in a patient with epileptic encephalopathy carrying a de novo COL4A1 mutation.

    Science.gov (United States)

    Hino-Fukuyo, Naomi; Kikuchi, Atsuo; Iwasaki, Masaki; Sato, Yuko; Kubota, Yuki; Kobayashi, Tomoko; Nakayama, Tojo; Haginoya, Kazuhiro; Arai-Ichinoi, Natsuko; Niihori, Tetsuya; Sato, Ryo; Suzuki, Tasuku; Kudo, Hiroki; Funayama, Ryo; Nakayama, Keiko; Aoki, Yoko; Kure, Shigeo

    2017-04-01

    We describe the first case of a successful functional hemispherectomy in a patient with epileptic encephalopathy and a de novo collagen type IV alpha 1 (COL4A1) mutation. A 4-year-old girl was COL4A1 mutation-positive and suffered from drug-resistant epilepsy, hemiplegia, and developmental delay. Magnetic resonance imaging detected no porencephaly, and she had no cataract or renal abnormality. Following a presurgical evaluation for epilepsy, she underwent a functional hemispherectomy. She has been seizure free with no intracranial hemorrhage or other perioperative complications. Patients with a COL4A1 mutation have an increased risk for intracranial hemorrhage because of disrupted integrity in the vascular basement membrane due to the mutation. After weighing the risks and benefits to these patients, epilepsy surgery may not be absolutely contraindicated. Furthermore, pediatric neurologists should be aware of an undiagnosed COL4A1 mutation when a patient presents with an unexplained neurological phenotype, such as mild hemiparesis, even in the absence of porencephaly. Copyright © 2016 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

  18. Asymptomatic parental mosaicism for osteogenesis imperfecta associated with a new splice site mutation in COL1A2

    OpenAIRE

    Frederiksen, Anja Lisbeth; Duno, Morten; Johnsen, Iben B. G.; Nielsen, Morten Frost; Kr?ig?rd, Anne Bruun

    2016-01-01

    Key Clinical Message Recurrent lethal perinatal osteogenesis imperfecta may result from asymptomatic parental mosaicism. A previously unreported mutation in COL1A2 leads to recurrent cases of fetal osteogenesis imperfecta Sillence type IIA, which emphasizes the importance of clinical and genetic evaluation of mosaicism in asymptomatic parents as verified mosaicism highly increases recurrence risk.

  19. A novel de novo COL1A1 mutation in a Thai boy with osteogenesis imperfecta born to consanguineous parents

    Directory of Open Access Journals (Sweden)

    Siraprapa Tongkobpetch

    2017-09-01

    Full Text Available Abstract Osteogenesis imperfecta (OI is genetically heterogeneous. Mutations in COL1A1 and COL1A2 are responsible for at least 90% of the cases, which are transmitted in an autosomal dominant manner or are de novo events. We identified a Thai boy with OI whose parents were first cousins. Because the proband was the product of a consanguineous marriage, we hypothesized that he might be homozygous for a mutation in a known gene causing a recessive form of OI. Using whole exome sequencing (WES, we did not find any pathogenic mutations in any known gene responsible for an autosomal recessive form of OI. Instead, we identified a COL1A1 frameshift mutation, c.1290delG (p.Gly431Valfs*110 in heterozygosis. By Sanger sequencing, the mutation was confirmed in the proband, and not detected in his parents, indicating that it was a de novo mutation. These findings had implication for genetic counseling. In conclusion, we expanded the mutational spectrum of COL1A1 and provided another example of a de novo pathogenic mutation in heterozygosis in a patient born to consanguineous parents.

  20. Identification of a candidate mutation in the COL1A2 gene of a Chow Chow with osteogenesis imperfecta.

    Science.gov (United States)

    Quist, E M; Doan, R; Pool, R R; Porter, B F; Bannasch, D L; Dindot, S V

    2017-09-19

    Osteogenesis imperfecta (OI) is a genetic disease that occurs in humans and animals. Individuals with OI exhibit signs of extreme bone fragility and osteopenia with frequent fractures and perinatal lethality in severe cases. In this study, we report the clinical diagnosis of OI in a dog and the use targeted next-generation sequencing to identify a candidate autosomal dominant mutation in the COL1A2 gene. A five-month old male Chow Chow was examined with a fractured left humerus and resolving, bilateral femoral fractures. Radiographs revealed generalized osteopenia and bilateral humeral, radial, and femoral fractures. Targeted next-generation sequencing of genes associated with OI in humans (COL1A1, COL1A2, LEPRE1, SERPINH1, and CRTAP) revealed a G>A heterozygous mutation in the splice donor site of exon 18 of the COL1A2 gene (c.936+1G>A). The splice donor mutation was not detected among 91 control dogs representing 21 breeds. A comparative analysis of exon 18 and the exon-intron junction further showed that the mutated splice donor site is conserved among vertebrates. Altogether, these findings reveal a candidate autosomal splice donor site mutation causing OI in an individual Chow Chow. © The American Genetic Association 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  1. Laser aircraft. [using kerosene

    Science.gov (United States)

    Hertzberg, A.; Sun, K.; Jones, W. S.

    1979-01-01

    The concept of a laser-powered aircraft is discussed. Laser flight would be completely compatible with existing airports and air-traffic control, with the airplane using kerosene only power, up to a cruising altitude of 9 km where the laser satellite would lock on and beam laser energy to it. Two major components make up the laser turbofan, a heat exchanger for converting laser radiation into thermal energy, and conventional turbomachinery. The laser power satellite would put out 42 Mw using a solar-powered thermal engine to generate electrical power for the closed-cycle supersonic electric discharge CO laser, whose radiators, heat exchangers, supersonic diffuser, and ducting will amount to 85% of the total subsystem mass. Relay satellites will be used to intercept the beam from the laser satellite, correct outgoing beam aberrations, and direct the beam to the next target. A 300-airplane fleet with transcontinental range is projected to save enough kerosene to equal the energy content of the entire system, including power and relay satellites, in one year.

  2. Aircraft exhaust sulfur emissions

    Energy Technology Data Exchange (ETDEWEB)

    Brown, R.C.; Anderson, M.R.; Miake-Lye, R.C.; Kolb, C.E. [Aerodyne Research, Inc., Billerica, MA (United States). Center for Chemical and Environmental Physics; Sorokin, A.A.; Buriko, Y.I. [Scientific Research Center `Ecolen`, Moscow (Russian Federation)

    1997-12-31

    The extent to which fuel sulfur is converted to SO{sub 3} during combustion and the subsequent turbine flow in supersonic and subsonic aircraft engines is estimated numerically. The analysis is based on: a flamelet model with non-equilibrium sulfur chemistry for the combustor, and a one-dimensional, two-stream model with finite rate chemical kinetics for the turbine. The results indicate that between 2% and 10% of the fuel sulfur is emitted as SO{sub 3}. It is also shown that, for a high fuel sulfur mass loading, conversion in the turbine is limited by the level of atomic oxygen at the combustor exit, leading to higher SO{sub 2} oxidation efficiency at lower fuel sulfur loadings. While SO{sub 2} and SO{sub 3} are the primary oxidation products, the model results further indicate H{sub 2}SO{sub 4} levels on the order of 0.1 ppm for supersonic expansions through a divergent nozzle. This source of fully oxidized S(6) (SO{sub 3} + H{sub 2}SO{sub 4}) exceeds previously calculated S(6) levels due to oxidation of SO{sub 2} by OH in the exhaust plume outside the engine nozzle. (author) 26 refs.

  3. CHROMagar COL-APSE: a selective bacterial culture medium for the isolation and differentiation of colistin-resistant Gram-negative pathogens

    DEFF Research Database (Denmark)

    Abdul Momin, Muhd Haziq F; Bean, David C; Hendriksen, Rene S.

    2017-01-01

    Purpose. A selective chromogenic culture medium for the laboratory isolation and differentiation of colistin resistant Acinetobacter, Pseudomonas, Stenotrophomonas and Enterobacteriaceae spp. (CHROMagar COL-APSE) was developed, evaluated and compared to an existing selective bacterial culture...... for the growth of COL-resistant bacterial pathogens. Due to the low limit of detection (101 c.f.u.), it may be useful as a primary isolation medium in the surveillance and recovery of COL-resistant bacteria from complex human, veterinary and environmental samples, especially those with plasmid-mediated MCR-1...... medium (SuperPolymyxin). Methodology. The medium was challenged with 84 isolates, including polymyxin B (POL B)-susceptible and -resistant type strains and colistin (COL)-resistant organisms recovered from human and animal samples. Susceptibility to COL and POL B was determined by agar dilution and broth...

  4. Speech systems for autonomous unmanned aircraft: enabling autonomous unmanned aircraft to communicate in civil airspace

    CSIR Research Space (South Africa)

    Burger, CR

    2011-09-01

    Full Text Available Airspace control is currently based largely on the exchange of speech between aircraft and Air Traffic Service Units, or between aircraft themselves. ICAO regulatory guidelines make no distinction between unmanned and manned aircraft, implying...

  5. Ball lightning risk to aircraft

    Science.gov (United States)

    Doe, R.; Keul, A.

    2009-04-01

    Lightning is a rare but regular phenomenon for air traffic. Aircraft are designed to withstand lightning strikes. Research on lightning and aircraft can be called detailed and effective. In the last 57 years, 18 reported lightning aviation disasters with a fatality figure of at least 714 persons occurred. For comparison, the last JACDEC ten-year average fatality figure was 857. The majority encountered lightning in the climb, descent, approach and/or landing phase. Ball lightning, a metastable, rare lightning type, is also seen from and even within aircraft, but former research only reported individual incidents and did not generate a more detailed picture to ascertain whether it constitutes a significant threat to passenger and aircraft safety. Lacking established incident report channels, observations were often only passed on as "air-travel lore". In an effort to change this unsatisfactory condition, the authors have collected a first international dataset of 38 documented ball lightning aircraft incidents from 1938 to 2001 involving 13 reports over Europe, 13 over USA/Canada, and 7 over Russia. 18 (47%) reported ball lightning outside the aircraft, 18 (47%) inside, 2 cases lacked data. 8 objects caused minor damage, 8 major damage (total: 42%), only one a crash. No damage was reported in 18 cases. 3 objects caused minor crew injury. In most cases, ball lightning lasted several seconds. 11 (29%) incidents ended with an explosion of the object. A cloud-aircraft lightning flash was seen in only 9 cases (24%) of the data set. From the detailed accounts of air personnel in the last 70 years, it is evident that ball lightning is rarely, but consistently observed in connection with aircraft and can also occur inside the airframe. Reports often came from multiple professional witnesses and in several cases, damages were investigated by civil or military authorities. Although ball lightning is no main air traffic risk, the authors suggest that incident and accident

  6. A rapid and efficient newly established method to detect COL1A1–PDGFB gene fusion in dermatofibrosarcoma protuberans

    International Nuclear Information System (INIS)

    Yokoyama, Yoko; Shimizu, Akira; Okada, Etsuko; Ishikawa, Osamu; Motegi, Sei-ichiro

    2012-01-01

    Highlights: ► We developed new method to rapidly identify COL1A1–PDGFB fusion in DFSP. ► New PCR method using a single primer pair detected COL1A1–PDGFB fusion in DFSP. ► This is the first report of DFSP with a novel COL1A1 breakpoint in exon 5. -- Abstract: The detection of fusion transcripts of the collagen type 1α1 (COL1A1) and platelet-derived growth factor-BB (PDGFB) genes by genetic analysis has recognized as a reliable and valuable molecular tool for the diagnosis of dermatofibrosarcoma protuberans (DFSP). To detect the COL1A1–PDGFB fusion, almost previous reports performed reverse transcription polymerase chain reaction (RT-PCR) using multiplex forward primers from COL1A1. However, it has possible technical difficulties with respect to the handling of multiple primers and reagents in the procedure. The objective of this study is to establish a rapid, easy, and efficient one-step method of PCR using only a single primer pair to detect the fusion transcripts of the COL1A1 and PDGFB in DFSP. To validate new method, we compared the results of RT-PCR in five patients of DFSP between the previous method using multiplex primers and our established one-step RT-PCR using a single primer pair. In all cases of DFSP, the COL1A1–PDGFB fusion was detected by both previous method and newly established one-step PCR. Importantly, we detected a novel COL1A1 breakpoint in exon 5. The newly developed method is valuable to rapidly identify COL1A1–PDGFB fusion transcripts in DFSP.

  7. Novel PAX9 and COL1A2 missense mutations causing tooth agenesis and OI/DGI without skeletal abnormalities.

    Science.gov (United States)

    Wang, Shih-Kai; Chan, Hui-Chen; Makovey, Igor; Simmer, James P; Hu, Jan C-C

    2012-01-01

    Inherited dentin defects are classified into three types of dentinogenesis imperfecta (DGI) and two types of dentin dysplasia (DD). The genetic etiology of DD-I is unknown. Defects in dentin sialophosphoprotein (DSPP) cause DD type II and DGI types II and III. DGI type I is the oral manifestation of osteogenesis imperfecta (OI), a systemic disease typically caused by defects in COL1A1 or COL1A2. Mutations in MSX1, PAX9, AXIN2, EDA and WNT10A can cause non-syndromic familial tooth agenesis. In this study a simplex pattern of clinical dentinogenesis imperfecta juxtaposed with a dominant pattern of hypodontia (mild tooth agenesis) was evaluated, and available family members were recruited. Mutational analyses of the candidate genes for DGI and hypodontia were performed and the results validated. A spontaneous novel mutation in COL1A2 (c.1171G>A; p.Gly391Ser) causing only dentin defects and a novel mutation in PAX9 (c.43T>A; p.Phe15Ile) causing hypodontia were identified and correlated with the phenotypic presentations in the family. Bone radiographs of the proband's dominant leg and foot were within normal limits. We conclude that when no DSPP mutation is identified in clinically determined isolated DGI cases, COL1A1 and COL1A2 should be considered as candidate genes. PAX9 mutation p.Phe15Ile within the N-terminal β-hairpin structure of the PAX9 paired domain causes tooth agenesis.

  8. Targeted deletion of RANKL in M cell inducer cells by the Col6a1-Cre driver.

    Science.gov (United States)

    Nagashima, Kazuki; Sawa, Shinichiro; Nitta, Takeshi; Prados, Alejandro; Koliaraki, Vasiliki; Kollias, George; Nakashima, Tomoki; Takayanagi, Hiroshi

    2017-11-04

    The gut-associated lymphoid tissues (GALTs), including Peyer's patches (PPs), cryptopatches (CPs) and isolated lymphoid follicles (ILFs), establish a host-microbe symbiosis by the promotion of immune reactions against gut microbes. Microfold cell inducer (MCi) cells in GALTs are the recently identified mesenchymal cells that express the cytokine RANKL and initiate bacteria-specific immunoglobulin A (IgA) production via induction of microfold (M) cell differentiation. In the previous study, the Twist2-Cre driver was utilized for gene deletion in mesenchymal cells including MCi cells. In order to investigate MCi cells more extensively, it will be necessary to develop experimental tools in addition to the Twist2-Cre driver mice and characterize such drivers in specificity and efficiency. Here we show that M cell differentiation and IgA production are impaired in the targeted deletion of RANKL by the Col6a1-Cre driver. We compared Col6a1-Cre with Twist2-Cre in terms of the specificity for mesenchymal cells in GALTs. Col6a1-Cre CAG-CAT-EGFP mice exhibited EGFP expression in podoplanin + CD31 - cells including MCi cells, while Twist2-Cre mice were shown to target endothelial cells and podoplanin + CD31 - cells. Tnfsf11 fl/Δ Col6a1-Cre mice exhibited the absence of M cells and severe IgA reduction together with an alteration in gut microbial composition. Moreover, we analyzed germ free mice to test whether changes in the microbiota are the cause of M cell deficiency. M cell differentiation was normal in the CPs/ILFs of germ free mice, indicating that MCi cells induce M cells independently of microbial colonization. This study demonstrates that Col6a1-Cre driver mice are as useful as Twist2-Cre driver mice for functional analyses of GALT-resident mesenchymal cells, including MCi cells. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. 77 FR 28533 - Special Conditions: Boeing, Model 737-800; Large Non-Structural Glass in the Passenger Compartment

    Science.gov (United States)

    2012-05-15

    ...-0499; Notice No. 25-12-01-SC] Special Conditions: Boeing, Model 737-800; Large Non-Structural Glass in... associated with the installation of large non-structural glass items in the cabin area of an executive... non-structural glass items in the cabin area of the executive interior occupied by passengers and crew...

  10. 76 FR 30523 - Special Conditions: Boeing Model 747-8/-8F Airplanes, Interaction of Systems and Structures

    Science.gov (United States)

    2011-05-26

    .... Boeing has proposed the addition of an Outboard Aileron Modal Suppression (OAMS) system to the fly-by..., these special conditions apply to fly-by-wire active flutter suppression systems that are intended to... to be a stable limit cycle oscillation (LCO), with the system operative and inoperative. (An LCO is...

  11. 75 FR 47180 - Airworthiness Directives; The Boeing Company Model 767-200, -300, and -300F Series Airplanes

    Science.gov (United States)

    2010-08-05

    ... 763 inclusive, except line number 758, which was accomplished in production. Subject (d) Air Transport... supplier part Nos. Boeing specification part No. Puritan Sierra Engineering Spencer Fluid Bennett Hydraflow... Archives and Records Administration (NARA). For information on the availability of this material at NARA...

  12. 75 FR 55455 - Airworthiness Directives; The Boeing Company Model 737-700 (IGW) Series Airplanes Equipped With...

    Science.gov (United States)

    2010-09-13

    ... should address the following actions. (1) Permanently drain auxiliary fuel tanks, and clear them of fuel... them at the pneumatic source, and secure them. (4) Disconnect all fuel feed and fuel vent plumbing... Airworthiness Directives; The Boeing Company Model 737-700 (IGW) Series Airplanes Equipped With Auxiliary Fuel...

  13. 75 FR 59167 - Airworthiness Directives; The Boeing Company Model 737-600, -700, -700C, -800, -900, and -900ER...

    Science.gov (United States)

    2010-09-27

    ... 2 and number 3 upper compression pads, and at the lower aft edge. A flight test at Boeing showed... upper compression pads 2 and 3 as applicable, inspecting for discrepancies of the inner wall of the... insulation blankets and heat transfer through the upper compression pad area and the fireseal bracket support...

  14. 75 FR 1527 - Airworthiness Directives; The Boeing Company Model 737-300, -400, and -500 Series Airplanes

    Science.gov (United States)

    2010-01-12

    ... station (STA) 827 and STA 847, and repair if necessary. This AD results from a report of a hole in the... three commenters. Support for the NPRM Boeing and the National Transportation Safety Board concur with.... ] Unsafe Condition (e) This AD results from a report of a hole in the fuselage skin common to stringer S-1...

  15. 78 FR 76731 - Special Conditions: Boeing Model 777-200, -300, and -300ER Series Airplanes; Rechargeable Lithium...

    Science.gov (United States)

    2013-12-19

    ... series airplanes have fly-by-wire controls, fully software-configurable avionics, and fiber-optic... Series Airplanes; Rechargeable Lithium Ion Batteries and Battery Systems AGENCY: Federal Aviation... Boeing Model 777- 200, -300, and -300ER series airplanes. These airplanes as modified by the ARINC...

  16. 76 FR 5061 - Special Conditions: TTF Aerospace, LLC, Modification to Boeing Model 767-300 Series Airplanes...

    Science.gov (United States)

    2011-01-28

    ..., will have a novel or unusual design features associated with the pilot lower lobe crew rest module (CRM... people to take part in this rulemaking by sending written comments, data, or views. The most helpful...) for installation of a lower lobe pilot crew rest module (CRM) in Boeing Model 767-300 series airplanes...

  17. 75 FR 71346 - Special Conditions: Boeing Model 787-8 Airplane; Lightning Protection of Fuel Tank Structure To...

    Science.gov (United States)

    2010-11-23

    ... Federal Aviation Administration 14 CFR Part 25 Special Conditions: Boeing Model 787-8 Airplane; Lightning... fuel vapor ignition caused by lightning strikes. The applicable airworthiness regulations do not... meet the requirements of that regulation for some areas of lightning protection for fuel tank structure...

  18. The Boeing Company's Tech Prep Story: A Community College Bridge to the School-to-Work Strategy.

    Science.gov (United States)

    Gayton, Carver; Parnell, Dale

    1996-01-01

    Reviews the Boeing Tech Prep Program, an associate degree program combining high school and community college vocational and academic curricula. Describes the three phases of the program's development: the provision of seed grants to schools, the development of an associate degree program, and the institution of an internship program. (MAB)

  19. 75 FR 82337 - Airworthiness Directives; The Boeing Company Model 777-200, -300, and -300ER Series Airplanes

    Science.gov (United States)

    2010-12-30

    ... airplane, and changing the wiring; and performing certain bonding resistance measurements and reworking the... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company... certain wiring changes. This proposed AD was prompted by results from fuel system reviews conducted by the...

  20. 76 FR 3856 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Science.gov (United States)

    2011-01-21

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company.... This proposed AD would require, depending on airplane configuration, doing certain wiring changes... new relays having a GFI feature, performing certain bonding resistance measurements, and modifying...

  1. 75 FR 81508 - Airworthiness Directives; The Boeing Company Model 777-200, -200LR, -300, and -300ER Series...

    Science.gov (United States)

    2010-12-28

    ... Directives; The Boeing Company Model 777-200, - 200LR, -300, and -300ER Series Airplanes AGENCY: Federal... installing new panels in the main equipment center, making certain wiring changes, installing new GFI relays... other airplanes, this proposed AD would require doing certain bond resistance measurements, and...

  2. 76 FR 24345 - Airworthiness Directives; The Boeing Company Model 777-200, -200LR, -300, and -300ER Series...

    Science.gov (United States)

    2011-05-02

    ...-146-AD; Amendment 39-16677; AD 2011-09-15] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... the main equipment center, making certain wiring changes, installing new GFI relays in the new panels..., this AD requires doing certain bond resistance measurements, and corrective actions if necessary. This...

  3. Aircraft Cabin Environmental Quality Sensors

    Energy Technology Data Exchange (ETDEWEB)

    Gundel, Lara; Kirchstetter, Thomas; Spears, Michael; Sullivan, Douglas

    2010-05-06

    The Indoor Environment Department at Lawrence Berkeley National Laboratory (LBNL) teamed with seven universities to participate in a Federal Aviation Administration (FAA) Center of Excellence (COE) for research on environmental quality in aircraft. This report describes research performed at LBNL on selecting and evaluating sensors for monitoring environmental quality in aircraft cabins, as part of Project 7 of the FAA's COE for Airliner Cabin Environmental Research (ACER)1 effort. This part of Project 7 links to the ozone, pesticide, and incident projects for data collection and monitoring and is a component of a broader research effort on sensors by ACER. Results from UCB and LBNL's concurrent research on ozone (ACER Project 1) are found in Weschler et al., 2007; Bhangar et al. 2008; Coleman et al., 2008 and Strom-Tejsen et al., 2008. LBNL's research on pesticides (ACER Project 2) in airliner cabins is described in Maddalena and McKone (2008). This report focused on the sensors needed for normal contaminants and conditions in aircraft. The results are intended to complement and coordinate with results from other ACER members who concentrated primarily on (a) sensors for chemical and biological pollutants that might be released intentionally in aircraft; (b) integration of sensor systems; and (c) optimal location of sensors within aircraft. The parameters and sensors were selected primarily to satisfy routine monitoring needs for contaminants and conditions that commonly occur in aircraft. However, such sensor systems can also be incorporated into research programs on environmental quality in aircraft cabins.

  4. Transition to Glass: Pilot Training for High-Technology Transport Aircraft

    Science.gov (United States)

    Wiener, Earl L.; Chute, Rebecca D.; Moses, John H.

    1999-01-01

    This report examines the activities of a major commercial air carrier between 1993 and late 1996 as it acquired an advanced fleet of high-technology aircraft (Boeing 757). Previously, the airline's fleet consisted of traditional (non-glass) aircraft, and this report examines the transition from a traditional fleet to a glass one. A total of 150 pilots who were entering the B-757 transition training volunteered for the study, which consisted of three query phases: (1) first day of transition training, (2) 3 to 4 months after transition training, and (3) 12 to 14 months after initial operating experience. Of these initial 150 pilots, 99 completed all three phases of the study, with each phase consisting of probes on attitudes and experiences associated with their training and eventual transition to flying the line. In addition to the three questionnaires, 20 in-depth interviews were conducted. Although the primary focus of this study was on the flight training program, additional factors such as technical support, documentation, and training aids were investigated as well. The findings generally indicate that the pilot volunteers were highly motivated and very enthusiastic about their training program. In addition, the group had low levels of apprehension toward automation and expressed a high degree of satisfaction toward their training. However, there were some concerns expressed regarding the deficiencies in some of the training aids and lack of a free-play flight management system training device.

  5. Modelling exhaust plume mixing in the near field of an aircraft

    Directory of Open Access Journals (Sweden)

    F. Garnier

    Full Text Available A simplified approach has been applied to analyse the mixing and entrainment processes of the engine exhaust through their interaction with the vortex wake of an aircraft. Our investigation is focused on the near field, extending from the exit nozzle until about 30 s after the wake is generated, in the vortex phase. This study was performed by using an integral model and a numerical simulation for two large civil aircraft: a two-engine Airbus 330 and a four-engine Boeing 747. The influence of the wing-tip vortices on the dilution ratio (defined as a tracer concentration shown. The mixing process is also affected by the buoyancy effect, but only after the jet regime, when the trapping in the vortex core has occurred. In the early wake, the engine jet location (i.e. inboard or outboard engine jet has an important influence on the mixing rate. The plume streamlines inside the vortices are subject to distortion and stretching, and the role of the descent of the vortices on the maximum tracer concentration is discussed. Qualitative comparison with contrail photograph shows similar features. Finally, tracer concentration of inboard engine centreline of B-747 are compared with other theoretical analyses and measured data.

  6. 75 FR 38391 - Special Conditions: Boeing 757-200 With Enhanced Flight Vision System

    Science.gov (United States)

    2010-07-02

    ...;Prices of new books are listed in the first FEDERAL REGISTER issue of each #0;week. #0; #0; #0; #0;#0..., Washington, on June 11, 2010. Jeffrey Duven, Acting Manager, Transport Airplane Directorate, Aircraft...

  7. Strain fields in Boeing 737 fuselage lap splices : field and laboratory measurements with analytical correlations

    Science.gov (United States)

    1995-06-01

    In support of the Federal Aviation Administration Technical Center's (FAATC) National Aging Aircraft Research Program (NAARP), Sandia National Laboratories and the John A. Volpe National Transportation Systems Center (Volpe Center) are conducting res...

  8. Airfoil optimization for morphing aircraft

    Science.gov (United States)

    Namgoong, Howoong

    Continuous variation of the aircraft wing shape to improve aerodynamic performance over a wide range of flight conditions is one of the objectives of morphing aircraft design efforts. This is being pursued because of the development of new materials and actuation systems that might allow this shape change. The main purpose of this research is to establish appropriate problem formulations and optimization strategies to design an airfoil for morphing aircraft that include the energy required for shape change. A morphing aircraft can deform its wing shape, so the aircraft wing has different optimum shapes as the flight condition changes. The actuation energy needed for moving the airfoil surface is modeled and used as another design objective. Several multi-objective approaches are applied to a low-speed, incompressible flow problem and to a problem involving low-speed and transonic flow. The resulting solutions provide the best tradeoff between low drag, high energy and higher drag, low energy sets of airfoil shapes. From this range of solutions, design decisions can be made about how much energy is needed to achieve a desired aerodynamic performance. Additionally, an approach to model aerodynamic work, which would be more realistic and may allow using pressure on the airfoil to assist a morphing shape change, was formulated and used as part of the energy objective. These results suggest that it may be possible to design a morphing airfoil that exploits the airflow to reduce actuator energy.

  9. Evaluation of two transport aircraft and several ground test vehicle friction measurements obtained for various runway surface types and conditions. A summary of test results from joint FAA/NASA Runway Friction Program

    Science.gov (United States)

    Yager, Thomas J.; Vogler, William A.; Baldasare, Paul

    1990-01-01

    Tests with specially instrumented NASA Boeing 737 and 727 aircraft together with several different ground friction measuring devices were conducted for a variety of runway surface types and conditions. These tests are part of joint FAA/NASA Aircraft/Ground Vehicle Runway Friction Program aimed at obtaining a better understanding of aircraft ground handling performance under adverse weather conditions and defining relationships between aircraft and ground vehicle tire friction measurements. Aircraft braking performance on dry, wet, snow and ice-covered runway conditions is discussed as well as ground vehicle friction data obtained under similar runway conditions. For a given contaminated runway surface condition, the correlation between ground vehicles and aircraft friction data is identified. The influence of major test parameters on friction measurements such as speed, test tire characteristics, type and amount of surface contaminant, and ambient temperature are discussed. The effect of surface type on wet friction levels is also evaluated from comparative data collected on grooved and ungrooved concrete and asphalt surfaces.

  10. CFD simulation of contrail formation in the near field of a commercial aircraft: Effect of fuel sulfur content

    Directory of Open Access Journals (Sweden)

    J.C. Khou

    2017-12-01

    Full Text Available Aircraft contrails may contribute to the global radiative forcing. In this context, the investigation of contrail formation in the near field of an aircraft may be helpful in developing strategies to reduce undesirable impacts. In this study, three-dimensional Reynolds-Averaged Navier-Stokes (RANS simulations of contrails produced by commercial aircraft during cruise flights were performed. A realistic geometry (herein a Boeing 737 was taken into account, including the engine core and bypass flows, which allows several parametrical studies and avoids using parameterizations to describe the plume's dilution. The objective was to simulate the early development of contrails in a fresh plume whose dilution was obtained with a spatial simulation of jet/vortex interaction. A coupling was carried out with a chemical and a microphysical model implemented in the numerical simulation code CEDRE to simulate particle growth using an Eulerian approach. The implemented microphysics model can simulate water condensation onto soot particles, taking into account their activation by adsorption of sulfur species. Our simulations show that sulfur dioxide is converted into sulfur trioxide and sulfuric acid at a rate of conversion close to 3 %, which is in good agreement with other studies. Ice-crystal growth was faster when the fuel sulfur content (FSC increased, allowing a visible contrail to appear earlier. These promising results confirm in situ observations and highlight the model's ability to simulate typical plume chemistry and complex microphysics/chemistry interactions coupled with detailed jet/vortex dynamics.

  11. Aircraft Skin Restoration and Evaluation

    Science.gov (United States)

    Yandouzi, M.; Gaydos, S.; Guo, D.; Ghelichi, R.; Jodoin, B.

    2014-12-01

    The recent development of the cold spray technology has made possible the deposition of low porosity and oxide-free coatings with good adhesion and with almost no change in the microstructure of the coated parts. This focuses on the use of low-pressure cold spray process to repair damaged Al-based aircraft skin, aiming at obtaining dense coatings with strong adhesion to the Al2024-T3 alloy. In order to prove the feasibility of using of the cold spray process as a repair process for aircraft skin, series of characterisation/tests including microstructures, microhardness, adhesion strength, three-point bending, surface finish, fatigue test, and corrosion resistance were performed. The obtained results revealed that the low-pressure cold spray process is a suitable for the repair of aircraft skin.

  12. Hydrogen aircraft and airport safety

    International Nuclear Information System (INIS)

    Schmidtchen, U.; Behrend, E.; Pohl, H.-W.; Rostek, N.

    1997-01-01

    First flight tests with a hydrogen demonstrator aircraft, currently under investigation in the scope of the German-Russia Cryoplane project, are scheduled for 1999. Regular service with regional aircraft may begin around 2005, followed by larger Airbus-type airliners around 2010-2015. The fuel storage aboard such airliners will be of the order of 15 t or roughly 200 m 3 LH 2 . This paper investigates a number of safety problems associated with the handling and air transport of so much hydrogen. The same is done for the infrastructure on the airport. Major risks are identified, and appropriate measures in design and operation are recommended. It is found that hydrogen aircraft are no more dangerous than conventional ones - safer in some respects. (author)

  13. ROCK inhibition stimulates SOX9/Smad3-dependent COL2A1 expression in inner meniscus cells.

    Science.gov (United States)

    Furumatsu, Takayuki; Maehara, Ami; Ozaki, Toshifumi

    2016-07-01

    Proper functioning of the meniscus depends on the composition and organization of its fibrocartilaginous extracellular matrix. We previously demonstrated that the avascular inner meniscus has a more chondrocytic phenotype compared with the outer meniscus. Inhibition of the Rho family GTPase ROCK, the major regulator of the actin cytoskeleton, stimulates the chondrogenic transcription factor Sry-type HMG box (SOX) 9-dependent α1(II) collagen (COL2A1) expression in inner meniscus cells. However, the crosstalk between ROCK inhibition, SOX9, and other transcription modulators on COL2A1 upregulation remains unclear in meniscus cells. The aim of this study was to investigate the role of SOX9-related transcriptional complex on COL2A1 expression under the inhibition of ROCK in human meniscus cells. Human inner and outer meniscus cells were prepared from macroscopically intact lateral menisci. Cells were cultured in the presence or absence of ROCK inhibitor (ROCKi, Y27632). Gene expression, collagen synthesis, and nuclear translocation of SOX9 and Smad2/3 were analyzed. Treatment of ROCKi increased the ratio of type I/II collagen double positive cells derived from the inner meniscus. In real-time PCR analyses, expression of SOX9 and COL2A1 genes was stimulated by ROCKi treatment in inner meniscus cells. ROCKi treatment also induced nuclear translocation of SOX9 and phosphorylated Smad2/3 in immunohistological analyses. Complex formation between SOX9 and Smad3 was increased by ROCKi treatment in inner meniscus cells. Chromatin immunoprecipitation analyses revealed that association between SOX9/Smad3 transcriptional complex with the COL2A1 enhancer region was increased by ROCKi treatment. This study demonstrated that ROCK inhibition stimulated SOX9/Smad3-dependent COL2A1 expression through the immediate nuclear translocation of Smad3 in inner meniscus cells. Our results suggest that ROCK inhibition can stimulates type II collagen synthesis through the cooperative activation

  14. Boeing Crew Exploration Vehicle Environmental Control and Life Support System Architecture Overview

    Science.gov (United States)

    Saiidi, Mo; Lewis, John F.

    2007-01-01

    The Boeing Company under the teaming agreement with the Northrop Grumman Systems Corporation and in compliance with the NASA Phase 1 contract, had the responsibilities for the CEV architecture development of the Environmental control and life support (ECLS) system under the NASA Phase 1 contract. The ECLS system was comprised of the various subsystems which provided for a shirt-sleeve habitable environment for crew to live and work in the crew module of the CEV. This architecture met the NASA requirements to ferry cargo and crew to ISS, and Lunar sortie missions, with extensibility to long duration missions to Moon and MARS. This paper provides a summary overview of the CEV ECLS subsystems which was proposed in compliance with the contract activities.

  15. After 24-hour scrub, the Boeing Delta II rocket carrying Stardust launches on time

    Science.gov (United States)

    1999-01-01

    Into a pristine blue sky, the Boeing Delta II rocket carrying the Stardust spacecraft leaves clouds of exhaust behind as it lifts off at 4:04:15 p.m. EST from Launch Pad 17-A, Cape Canaveral Air Station. Stardust is destined for a close encounter with the comet Wild 2 in January 2004. Using a silicon-based substance called aerogel, Stardust will capture comet particles flying off the nucleus of the comet. The spacecraft also will bring back samples of interstellar dust. These materials consist of ancient pre-solar interstellar grains and other remnants left over from the formation of the solar system. Scientists expect their analysis to provide important insights into the evolution of the sun and planets and possibly into the origin of life itself. The collected samples will return to Earth in a sample return capsule to be jettisoned as Stardust swings by Earth in January 2006.

  16. Langley's Computational Efforts in Sonic-Boom Softening of the Boeing HSCT

    Science.gov (United States)

    Fouladi, Kamran

    1999-01-01

    NASA Langley's computational efforts in the sonic-boom softening of the Boeing high-speed civil transport are discussed in this paper. In these efforts, an optimization process using a higher order Euler method for analysis was employed to reduce the sonic boom of a baseline configuration through fuselage camber and wing dihedral modifications. Fuselage modifications did not provide any improvements, but the dihedral modifications were shown to be an important tool for the softening process. The study also included aerodynamic and sonic-boom analyses of the baseline and some of the proposed "softened" configurations. Comparisons of two Euler methodologies and two propagation programs for sonic-boom predictions are also discussed in the present paper.

  17. STS-65 crewmembers and backup participate in bench review at Boeing Building

    Science.gov (United States)

    1994-01-01

    STS-65 crewmembers, wearing clean suits, look over equipment to be carried aboard the Space Shuttle Columbia, Orbiter Vehicle (OV) 102, for the scheduled July flight of the second International Microgravity Laboratory (IML-2) mission. Surrounding a table full of equipment at Boeing's Flight Equipment Processing Facility near the Johnson Space Center (JSC), are (left to right) Mission Specialist (MS) Leroy Chiao, MS Donald A. Thomas, Commander Robert D. Cabana, Payload Specialist Chiaki Mukai, Payload Commander (PLC) Richard J. Hieb, and backup (alternate) payload specialist Jean-Jacques Favier. Mukai represents Japan's National Space Development Agency (NASDA) and Favier represents France's Centre National d'Etudes Spatiales. Photo taken by NASA JSC contract photographer Scott A. Wickes.

  18. Linkage mapping of the gene for Type III collagen (COL3A1) to human chromosome 2q using a VNTR polymorphism

    Energy Technology Data Exchange (ETDEWEB)

    Tiller, G.E.; Polumbo, P.A.; Summar, M.L. (Vanderbilt Univ. Medical Center, Nashville, TN (United States))

    1994-03-15

    The gene for the [alpha]1(III) chain of type III collagen, COL3A1, has been previously mapped to human chromosome 2q24.3-q31 by in situ hybridization. Physical mapping by pulsed-field gel electrophoresis has demonstrated that COL3A1 lies within 35 kb of COL5A2. The authors genotyped the CEPH families at the COL3A2 locus using a pentanucleotide repeat polymorphism within intron 25. They demonstrated significant linkage to 18 anonymous markers as well as the gene for carbamyl phosphate synthetase (CPSI), which had been previously mapped to this region. No recombination was seen between COL3A1 and COL5A2 (Z = 9.93 at [theta] = 0) or D2S24 (Z = 10.55 at [theta] = 0). The locus order is (D2S32-D2S138-D2S148)-(D2S24-COL5A2-COL3A1)-(D2S118-D2S161), with odds of 1:2300 for the next most likely order. These relationships are consistent with the physical mapping of COL3A1 to the distal portion of 2q and place it proximal to CPSI by means of multipoint analysis. These linkage relationships should prove useful in further studies of Ehlers-Danlos syndrome type IV and carbamyl phosphate synthetase I deficiency and provide an additional framework for localizing other genes in this region. 13 refs., 2 figs., 1 tab.

  19. An apple B-box protein, MdCOL11, is involved in UV-B- and temperature-induced anthocyanin biosynthesis.

    Science.gov (United States)

    Bai, Songling; Saito, Takanori; Honda, Chikako; Hatsuyama, Yoshimichi; Ito, Akiko; Moriguchi, Takaya

    2014-11-01

    Our studies showed that an apple B-box protein, MdCOL11, the homolog of AtBBX22, is involved in UV-B- and temperature-induced anthocyanin biosynthesis in apple peel. Anthocyanin is responsible for the red pigmentation in apple peel and a R2R3 MYB gene, MdMYBA/1/10, a homolog of MdMYBA, controls its accumulation. Arabidopsis PAP1 is under the control of a series of upstream factors involved in light signal transduction and photomorphogenesis, such as ELONGATED HYPOCOTYL 5 (HY5) and B-box family (BBX) proteins. In this study, we identified and characterized the homolog of Arabidopsis BBX22 in apple, designated as MdCOL11. Overexpression of MdCOL11 in Arabidopsis enhanced the accumulation of anthocyanin. In apples, MdCOL11 was differentially expressed in all tissues, with the highest expression in petals and the lowest expression in the xylem. Transcripts of MdCOL11 noticeably accumulated at the ripening stage, concomitant with increases in the expressions of anthocyanin biosynthesis-related genes. In an in vitro treatment experiment, MdCOL11 was upregulated in an ultra-violet (UV)-B- and temperature-dependent manner, together with the inductions of anthocyanin biosynthesis-related genes and anthocyanin accumulation in apple peel. Furthermore, a dual-luciferase assay indicated that (1) MdCOL11 regulated the expression of MdMYBA and (2) MdCOL11 was a target of MdHY5. Taken together, our results suggest that MdCOL11 is involved in MdHY5-mediated signal transduction and regulates anthocyanin accumulation in apple peel, which sheds new light on anthocyanin accumulation in apples.

  20. Alternative general-aircraft engines

    Science.gov (United States)

    Tomazic, W. A.

    1976-01-01

    The most promising alternative engine (or engines) for application to general aircraft in the post-1985 time period was defined, and the level of technology was cited to the point where confident development of a new engine can begin early in the 1980's. Low emissions, multifuel capability, and fuel economy were emphasized. Six alternative propulsion concepts were considered to be viable candidates for future general-aircraft application: the advanced spark-ignition piston, rotary combustion, two- and four-stroke diesel, Stirling, and gas turbine engines.

  1. Future aircraft networks and schedules

    Science.gov (United States)

    Shu, Yan

    2011-07-01

    Because of the importance of air transportation scheduling, the emergence of small aircraft and the vision of future fuel-efficient aircraft, this thesis has focused on the study of aircraft scheduling and network design involving multiple types of aircraft and flight services. It develops models and solution algorithms for the schedule design problem and analyzes the computational results. First, based on the current development of small aircraft and on-demand flight services, this thesis expands a business model for integrating on-demand flight services with the traditional scheduled flight services. This thesis proposes a three-step approach to the design of aircraft schedules and networks from scratch under the model. In the first step, both a frequency assignment model for scheduled flights that incorporates a passenger path choice model and a frequency assignment model for on-demand flights that incorporates a passenger mode choice model are created. In the second step, a rough fleet assignment model that determines a set of flight legs, each of which is assigned an aircraft type and a rough departure time is constructed. In the third step, a timetable model that determines an exact departure time for each flight leg is developed. Based on the models proposed in the three steps, this thesis creates schedule design instances that involve almost all the major airports and markets in the United States. The instances of the frequency assignment model created in this thesis are large-scale non-convex mixed-integer programming problems, and this dissertation develops an overall network structure and proposes iterative algorithms for solving these instances. The instances of both the rough fleet assignment model and the timetable model created in this thesis are large-scale mixed-integer programming problems, and this dissertation develops subproblem schemes for solving these instances. Based on these solution algorithms, this dissertation also presents

  2. Dryden F-8 Research Aircraft Fleet 1973 in flight, DFBW and SCW

    Science.gov (United States)

    1973-01-01

    F-8 Digital Fly-By-Wire (left) and F-8 Supercritical Wing in flight. These two aircraft fundamentally changed the nature of aircraft design. The F-8 DFBW pioneered digital flight controls and led to such computer-controlled airacrft as the F-117A, X-29, and X-31. Airliners such as the Boeing 777 and Airbus A320 also use digital fly-by-wire systems. The other aircraft is a highly modified F-8A fitted with a supercritical wing. Dr. Richard T. Whitcomb of Langley Research Center originated the supercritical wing concept in the late 1960s. (Dr. Whitcomb also developed the concept of the 'area rule' in the early 1950s. It singificantly reduced transonic drag.) The F-8 Digital Fly-By-Wire (DFBW) flight research project validated the principal concepts of all-electric flight control systems now used on nearly all modern high-performance aircraft and on military and civilian transports. The first flight of the 13-year project was on May 25, 1972, with research pilot Gary E. Krier at the controls of a modified F-8C Crusader that served as the testbed for the fly-by-wire technologies. The project was a joint effort between the NASA Flight Research Center, Edwards, California, (now the Dryden Flight Research Center) and Langley Research Center. It included a total of 211 flights. The last flight was December 16, 1985, with Dryden research pilot Ed Schneider at the controls. The F-8 DFBW system was the forerunner of current fly-by-wire systems used in the space shuttles and on today's military and civil aircraft to make them safer, more maneuverable, and more efficient. Electronic fly-by-wire systems replaced older hydraulic control systems, freeing designers to design aircraft with reduced in-flight stability. Fly-by-wire systems are safer because of their redundancies. They are more maneuverable because computers can command more frequent adjustments than a human pilot can. For airliners, computerized control ensures a smoother ride than a human pilot alone can provide

  3. Cartografia e deficiência visual: experiências no Colégio Pedro II

    Directory of Open Access Journals (Sweden)

    Rafael Medeiros de Andrade

    2014-01-01

    Full Text Available O processo de construção de uma escola inclusiva perpassa um conjunto de esforços cognitivos e técnicos por parte da comunidade escolar que são necessários para a adequada educação e desenvolvimento do aluno. No que diz respeito ao ensino de Geografia para alunos deficientes visuais, fazem parte deste conjunto de medidas o domínio do sistema Braille, a confecção de materiais e mapas táteis, a gravação de textos em áudio e, entre outras, a realização de trabalhos de campo. O presente relato de experiência refere-se à um projeto de dedicação exclusiva, implementado no Colégio Pedro II de 2008 a 2010, cujo objetivo foi aprimorar o ensino de Geografia para os alunos deficientes visuais. Conclui-se que a adoção dessas medidas representa o início de um longo trabalho de toda comunidade escolar que não pode ser resumido à existência de alguns materiais táteis. Deve, por outro lado, envolver um processo de construção e adequação instrumental, acompanhado da capacitação profissional e da sensibilização da comunidade escolar.

  4. Osteoporosis and Related Genes: VDR, ESR And COL1A1

    Directory of Open Access Journals (Sweden)

    Sabriye Kocaturk Sel

    2011-08-01

    Full Text Available Osteoporosis is now considered as one of the major and growing health care problems around the world. Osteoporosis is the most prevalent metabolic bone disease among developed countries and it is defined as a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility. Bone is a highly metabolically active tissue in which the processes of osteoblastic bone formation and osteoclastic bone resorption are continuous throughout life. Coupling of osteoblast and osteoclast action ensures that a normal bone structure is maintained. A loss of bone homeostasis may result in a decrease in bone mass leading to osteoporosis or in a defect in the mineralization of bone. Numerous genetic, hormonal, nutritional and life-style factors contribute to the acquisition and maintenance of bone mass. Among them, genetic variations explain as much as 50-80% of the variance for bone mineral density (BMD in the population. Many genes that could be related to osteoporosis have been studied and of them all Vitamin D receptor (VDR, estrogen receptor alpha (ESRα and collagen 1 alpha 1 chain (COL1A1 genes have been the most focused on. [Archives Medical Review Journal 2011; 20(4.000: 246-269

  5. Xarxa interclase: un projecte col·laboratiu mitjançant tecnologies digitals

    Directory of Open Access Journals (Sweden)

    Françoise Olmo Cazevieille

    2015-12-01

    Full Text Available Focalitzem aquest treball en l'aportació de les tecnologies de la informació i la comunicació (TIC a la pràctica i el desenvolupament d'una llengua estrangera i en els avantatges que ofereixen per a la creació d'activitats basades en la col·laboració i la interacció. Sense aquestes, tant els treballs en equip amb nadius com la cerca d'informació sobre temes especialitzats en la llengua estudiada serien complexos de dur a terme. En aquest article presentem el procediment seguit en un projecte didàctic, Xarxa interclasse, entre dues assignatures basades en l'aprenentatge de llengües estrangeres per a fins específics en un mateix campus universitari.?Es pretén, d'una banda, acostar l'educació superior a les exigències de la societat actual i, d'altra banda, aconseguir una docència motivadora i una participació activa dels discents on la tecnologia s'integra com a element pedagògic.

  6. 47 CFR 32.2113 - Aircraft.

    Science.gov (United States)

    2010-10-01

    ... FOR TELECOMMUNICATIONS COMPANIES Instructions for Balance Sheet Accounts § 32.2113 Aircraft. This account shall include the original cost of aircraft and any associated equipment and furnishings installed...

  7. Military Airlift: The Joint Cargo Aircraft Program

    National Research Council Canada - National Science Library

    Knight, William

    2007-01-01

    Joint Cargo Aircraft (JCA) is a joint acquisition program between the Army and the Air Force designed to procure a commercial off-the-shelf aircraft, capable of meeting Army requirements for "direct support" to maneuver units...

  8. Military Airlift: The Joint Cargo Aircraft Program

    National Research Council Canada - National Science Library

    Hess, Allan

    2008-01-01

    Joint Cargo Aircraft (JCA) is a joint acquisition program between the Army and Air Force intended to procure a commercial off-the-shelf aircraft capable of meeting Army and Air Force requirements for intra-theater airlift...

  9. Estimation of nuclear power plant aircraft hazards

    International Nuclear Information System (INIS)

    Gottlieb, P.

    1978-01-01

    The standard procedures for estimating aircraft risk to nuclear power plants provide a conservative estimate, which is adequate for most sites, which are not close to airports or heavily traveled air corridors. For those sites which are close to facilities handling large numbers of aircraft movements (airports or corridors), a more precise estimate of aircraft impact frequency can be obtained as a function of aircraft size. In many instances the very large commercial aircraft can be shown to have an acceptably small impact frequency, while the very small general aviation aircraft will not produce sufficiently serious impact to impair the safety-related functions. This paper examines the in between aircraft: primarily twin-engine, used for business, pleasure, and air taxi operations. For this group of aircraft the total impact frequency was found to be approximately once in one million years, the threshold above which further consideration of specific safety-related consequences would be required

  10. Versatile Electric Propulsion Aircraft Testbed, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — An all-electric aircraft testbed is proposed to provide a dedicated development environment for the rigorous study and advancement of electrically powered aircraft....

  11. Different NaCl-Induced Calcium Signatures in the Arabidopsis thaliana Ecotypes Col-0 and C24

    KAUST Repository

    Schmöckel, Sandra M.

    2015-02-27

    A common feature of stress signalling pathways are alterations in the concentration of cytosolic free calcium ([Ca2+]cyt), which allow the specific and rapid transmission of stress signals through a plant after exposure to a stress, such as salinity. Here, we used an aequorin based bioluminescence assay to compare the NaCl-induced changes in [Ca2+]cyt of the Arabidopsis ecotypes Col-0 and C24. We show that C24 lacks the NaCl specific component of the [Ca2+]cyt signature compared to Col-0. This phenotypic variation could be exploited as a screening methodology for the identification of yet unknown components in the early stages of the salt signalling pathway.

  12. La col·lecció de primats del Museu de Ciències Naturals de Barcelona (Espanya)

    OpenAIRE

    Veracini, C.; García-Franquesa, E.

    2010-01-01

    L'MCNB conserva un total de 309 exemplars de primats no humans. La col·lecció consta de 102 exemplars dissecats, 33 pells, 73 esquelets, 24 esquelets postcranials, vuit esquelets muntats, 54 cranis, tres animals sencers en alcohol i 31 mostres d'altres tipus (ossos o altres). Els darrers anys s'ha portat a terme una revisió completa i una reorganització de la col·lecció. Amb 39 gèneres, aquesta inclou una àmplia gamma de primats no humans. Conté mostres d'Àfrica, Àsia i Amèrica del Sud i Cent...

  13. A novel splicing mutation in COL1A1 gene caused type I osteogenesis imperfecta in a Chinese family.

    Science.gov (United States)

    Peng, Hao; Zhang, Yuhui; Long, Zhigao; Zhao, Ding; Guo, Zhenxin; Xue, Jinjie; Xie, Zhiguo; Xiong, Zhimin; Xu, Xiaojuan; Su, Wei; Wang, Bing; Xia, Kun; Hu, Zhengmao

    2012-07-10

    Osteogenesis imperfect (OI) is a heritable connective tissue disorder with bone fragility as a cardinal manifestation, accompanied by short stature, dentinogenesis imperfecta, hyperlaxity of ligaments and skin, blue sclerae and hearing loss. Dominant form of OI is caused by mutations in the type I procollagen genes, COL1A1/A2. Here we identified a novel splicing mutation c.3207+1G>A (GenBank ID: JQ236861) in the COL1A1 gene that caused type I OI in a Chinese family. RNA splicing analysis proved that this mutation created a new splicing site at c.3200, and then led to frameshift. This result further enriched the mutation spectrum of type I procollagen genes. Copyright © 2012 Elsevier B.V. All rights reserved.

  14. 75 FR 81427 - Airworthiness Directives; The Boeing Company Model 747-200C, -200F, -400, -400D, and -400F Series...

    Science.gov (United States)

    2010-12-28

    ... Certain Language in Paragraph (k) of the NPRM Boeing asked that we revise the language in paragraph (k) of... Information Japan Airlines (JAL) asked that we delay issuance until the manufacturer can release Revision 2 of...

  15. Aircraft height estimation using 2-D radar

    CSIR Research Space (South Africa)

    Hakl, H

    2010-01-01

    Full Text Available A method to infer height information from an aircraft tracked with a single 2-D search radar is presented. The method assumes level flight in the target aircraft and a good estimate of the speed of the aircraft. The method yields good results...

  16. 31 CFR 560.528 - Aircraft safety.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Aircraft safety. 560.528 Section 560..., Authorizations and Statements of Licensing Policy § 560.528 Aircraft safety. Specific licenses may be issued on a... the safety of civil aviation and safe operation of U.S.-origin commercial passenger aircraft. ...

  17. Unmanned Cargo Aircraft : From Anywhere to Everywhere

    NARCIS (Netherlands)

    Heerkens, Hans

    2017-01-01

    While unmanned aircraft have been in use for decades, their suitability for transporting cargo is only now slowly being recognised. The first prototypes of unmanned cargo aircraft (UCA) are currently being tested. There are two categories of UCA: short-distance aircraft for delivering packages and

  18. Policy and the evaluation of aircraft noise

    NARCIS (Netherlands)

    Kroesen, M.; Molin, E.J.E.; Van Wee, G.P.

    2010-01-01

    In this paper, we hypothesize and test the ideas that (1) people’s subjectivity in relation to aircraft noise is shaped by the policy discourse, (2) this results in a limited number of frames towards aircraft noise, (3) the frames inform people how to think and feel about aircraft noise and (4) the

  19. 14 CFR 91.117 - Aircraft speed.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Aircraft speed. 91.117 Section 91.117... speed. (a) Unless otherwise authorized by the Administrator, no person may operate an aircraft below 10... than the maximum speed prescribed in this section, the aircraft may be operated at that minimum speed. ...

  20. Impact analysis of composite aircraft structures

    Science.gov (United States)

    Pifko, Allan B.; Kushner, Alan S.

    1993-01-01

    The impact analysis of composite aircraft structures is discussed. Topics discussed include: background remarks on aircraft crashworthiness; comments on modeling strategies for crashworthiness simulation; initial study of simulation of progressive failure of an aircraft component constructed of composite material; and research direction in composite characterization for impact analysis.