WorldWideScience

Sample records for boeing aircraft col

  1. 78 FR 61388 - TA-W-82,705, the Boeing Company Boeing Commercial Aircraft, (BCA) Including On-Site Leased...

    Science.gov (United States)

    2013-10-03

    ... Employment and Training Administration TA-W-82,705, the Boeing Company Boeing Commercial Aircraft, (BCA..., Washington; TA-W-82,705A, the Boeing Company Boeing Commercial Aircraft, (BCA) Including On-Site Leased... International, Volt Services and Yoh Services Everett, Washington; TA-W-82,705B, The Boeing Company...

  2. Advanced composite elevator for Boeing 727 aircraft

    Science.gov (United States)

    1979-01-01

    Detail design activities are reported for a program to develop an advanced composites elevator for the Boeing 727 commercial transport. Design activities include discussion of the full scale ground test and flight test activities, the ancillary test programs, sustaining efforts, weight status, and the production status. Prior to flight testing of the advanced composites elevator, ground, flight flutter, and stability and control test plans were reviewed and approved by the FAA. Both the ground test and the flight test were conducted according to the approved plan, and were witnessed by the FAA. Three and one half shipsets have now been fabricated without any significant difficulty being encountered. Two elevator system shipsets were weighed, and results validated the 26% predicted weight reduction. The program is on schedule.

  3. Advanced composite elevator for Boeing 727 aircraft. Volume 1: Technical summary

    Science.gov (United States)

    Chovil, D. V.; Harvey, S. T.; Mccarty, J. E.; Desper, O. E.; Jamison, E. S.; Syder, H.

    1981-01-01

    The design, development, analysis, and testing activities and results that were required to produce five and one-half shipsets of advanced composite elevators for Boeing 727 aircraft are summarized. During the preliminary design period, alternative concepts were developed. After selection of the best design, detail design and basic configuration improvements were evaluated. Five and one-half shipsets were manufactured. All program goals (except competitive cost demonstration) were accomplished when our design met or exceeded all requirements, criteria, and objectives.

  4. Parametric Evaluation of Absorption Losses and Comparison of Numerical Results to Boeing 707 Aircraft Experimental HIRF Results

    Science.gov (United States)

    Kitaygorsky, J.; Amburgey, C.; Elliott, J. R.; Fisher, R.; Perala, R. A.

    A broadband (100 MHz-1.2 GHz) plane wave electric field source was used to evaluate electric field penetration inside a simplified Boeing 707 aircraft model with a finite-difference time-domain (FDTD) method using EMA3D. The role of absorption losses inside the simplified aircraft was investigated. It was found that, in this frequency range, none of the cavities inside the Boeing 707 model are truly reverberant when frequency stirring is applied, and a purely statistical electromagnetics approach cannot be used to predict or analyze the field penetration or shielding effectiveness (SE). Thus it was our goal to attempt to understand the nature of losses in such a quasi-statistical environment by adding various numbers of absorbing objects inside the simplified aircraft and evaluating the SE, decay-time constant τ, and quality factor Q. We then compare our numerical results with experimental results obtained by D. Mark Johnson et al. on a decommissioned Boeing 707 aircraft.

  5. Auxiliary power unit noise of Boeing B737 and B747 aircraft

    Science.gov (United States)

    Kwan, Jimmy S. W.; Yang, S. J. Eric

    Most modern civil aircraft have an Auxiliary Power Unit (APU) which provides compressed air for engine starting and the air-conditioning system on ground and electrical power for aircraft use both on-ground and in-fligth. It is basically a gas turbine engine and it consists of a compressor section, a turbine section, and an accessory drive section. For Boeing B737 and B747 aircraft, the APU is located inside a compartment in the tail section of the aircraft and is completely enclosed by a sound-reduction fire-proof titanium shroud. APU noise is one of the major noise sources at many airports and is extremely important for a densely populated city such as Hong Kong. The noise from APU can affect many people, including ground crew aircraft maintenance staff, and people living in the vicinity of the airport. However, there is very little information available in the literature about APU noise. This paper describes the noise measurement method and presents the measurement results for APUs of one B747 and two B737 aircraft under both 'loaded' and 'no-load' conditions.

  6. The design, development, and flight test results of the Boeing 737 aircraft antennas for the ICAO demonstration of the TRSB microwave landing system

    Science.gov (United States)

    Campbell, T. G.; White, W. E.; Gilreath, M. C.

    1976-01-01

    The Research Support Flight System, a modified Boeing 737, was used to evaluate the performance of several aircraft antennas and locations for the Time Reference Scanning Beam (TRSB) Microwave Landing System (MLS). These tests were conducted at the National Aviation Facilities Experimental Center (NAFEC), Atlantic City, New Jersey on December 18, 1975. The flight tests measured the signal strength and all pertinent MLS data during a straight-in approach, a racetrack approach, and ICAO approach profiles using the independent antenna-receiver combinations simultaneously on the aircraft. Signal drop-outs were experienced during the various approaches but only a small percentage could be attributed to antenna pattern effects.

  7. 78 FR 70848 - Special Conditions: Boeing Model 777-200, -300, and -300ER Series Airplanes; Aircraft Electronic...

    Science.gov (United States)

    2013-11-27

    .... The Boeing Model 777-200 airplanes are long-range, wide-body, twin-engine jet airplanes with a maximum... networks connected to systems that perform functions required for the safe operation of the airplane. This... allow increased connectivity to, or access by, external airplane sources, airline operations,...

  8. 78 FR 70849 - Special Conditions: Boeing Model 777-200, -300, and -300ER Series Airplanes; Aircraft Electronic...

    Science.gov (United States)

    2013-11-27

    .... The Boeing Model 777-200 airplanes are long-range, wide-body, twin-engine jet airplanes with a maximum... networks connected to systems that perform functions required for the safe operation of the airplane. This... required for safe flight and operations. 2. The applicant must establish appropriate procedures to...

  9. Boeing and EGAT Unveil World's First Large Cargo Freighter——Evergreen Aviation Technologies transforms Boeing747-400 for 787 Dreamliner cargo

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Evergreen Aviation Technologies Corporation (EGAT), a subsidiary of the Evergreen Group, and The Boeing Company unveiled the first of three Boeing 747-400 Large Cargo Freighters (LCF) modified to exacting specifications to transport giant-sized Boeing 787 "Dreamliner" assemblages.Boeing selected EGAT to perform the specialized aircraft conversions and work began in 2005. The three-aircraft conversion program will be completed in 2007.

  10. "Air Queen" Boeing 747’s Anniversary

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正>The world’s well-known Boeing 747 aircraft completed its maiden flight on February 9, 1969, rewriting the history of the world’s civil aviation.Since 1970 when it was put into operation, Boeing 747s,dubbed as "air queen," have carried 3.6 billion passengers by flying for 64.8

  11. Boeing-AX Jet-Effects Model

    Science.gov (United States)

    1994-01-01

    This model of the Boeing A/FX (Advanced Attack/Fighter) Aircraft was photographed between test runs in NASA Langley Research Center's 16-Foot Transonic Tunnel. Testing was conducted to determine the effects of the jet exhaust on the aerodynamic characteristics of the aircraft afterbody. The A/FX program was a Navy effort to obtain a next-generation replacement for the A-6 and F/A-18. The A/FX program evolved into the current multi-service JSF (Joint Strike Fighter) program.

  12. Aircraft

    Science.gov (United States)

    Hibbs, B.D.; Lissaman, P.B.S.; Morgan, W.R.; Radkey, R.L.

    1998-09-22

    This disclosure provides a solar rechargeable aircraft that is inexpensive to produce, is steerable, and can remain airborne almost indefinitely. The preferred aircraft is a span-loaded flying wing, having no fuselage or rudder. Travelling at relatively slow speeds, and having a two-hundred foot wingspan that mounts photovoltaic cells on most all of the wing`s top surface, the aircraft uses only differential thrust of its eight propellers to turn. Each of five sections of the wing has one or more engines and photovoltaic arrays, and produces its own lift independent of the other sections, to avoid loading them. Five two-sided photovoltaic arrays, in all, are mounted on the wing, and receive photovoltaic energy both incident on top of the wing, and which is incident also from below, through a bottom, transparent surface. The aircraft is capable of a top speed of about ninety miles per hour, which enables the aircraft to attain and can continuously maintain altitudes of up to sixty-five thousand feet. Regenerative fuel cells in the wing store excess electricity for use at night, such that the aircraft can sustain its elevation indefinitely. A main spar of the wing doubles as a pressure vessel that houses hydrogen and oxygen gases for use in the regenerative fuel cell. The aircraft has a wide variety of applications, which include weather monitoring and atmospheric testing, communications, surveillance, and other applications as well. 31 figs.

  13. 波音777飞机高升力控制系统余度管理分析%Redundancy Management for High Lift Control System Based on Boeing 777 Aircraft

    Institute of Scientific and Technical Information of China (English)

    杜永良; 潘妍红

    2012-01-01

    It is prevalent that flight control system design using redundancy concept to improve mission reliability. The efficiency of redundancy components are mainly decided by redundancy management strategies and methods. Based on Boeing 777 aircraft High lift control system architecture, redundancy management methods was studied in this paper by the combination of online monitor and signal voting. The wire disposing methods, hardware design methods and software design methods are fully considered in the process of designing redundancy management meth- ods, as a result, not only the flap/slat electronic unit hardware but also its software are simplified, the system relia- bility is also improved. The design concept and methods use in this paper can be importance reference to similar system design.%飞行控制系统普遍采用余度技术来提高自身的任务可靠性。余度部件效能的发挥程度主要取决于余度管理策略和方法。根据波音777飞机高升力控制系统的基本构架。通过在线监控与信号表决相结合的方法对系统余度管理方法进行研究。在余度管理方法的设计过程中,充分考虑了布线技术、硬件设计技术及与软件相结合的方法,不但简化了襟缝翼控制器的硬件设计,同时也简化了控制器软件的设计难度,提高了系统可靠性,所用到的方法对同类系统设计有一定的参考价值。

  14. Nuclear containment structure subjected to commercial and fighter aircraft crash

    Energy Technology Data Exchange (ETDEWEB)

    Sadique, M.R., E-mail: rehan.sadique@gmail.com; Iqbal, M.A., E-mail: iqbalfce@iitr.ernet.in; Bhargava, P., E-mail: bhpdpfce@iitr.ernet.in

    2013-07-15

    Highlights: • Nuclear containment response has been studied against aircraft crash. • Concrete damaged plasticity and Johnson–Cook elasto-viscoplastic models were employed. • Boeing 747-400 and Boeing 767-400 aircrafts caused global failure of containment. • Airbus A320 and Boeing 707-320 aircrafts caused local damage. • Tension damage of concrete was found more prominent compared to compression damage. -- Abstract: The response of a boiling water reactor (BWR) nuclear containment vessel has been studied against commercial and fighter aircraft crash using a nonlinear finite element code ABAQUS. The aircrafts employed were Boeing 747-400, Boeing 767-400, Airbus A-320, Boeing 707-320 and Phantom F4. The containment was modeled as a three-dimensional deformable reinforced concrete structure while the loading of aircraft was assigned using the respective reaction–time curve. The location of strike was considered near the junction of dome and cylinder, and the angle of incidence, normal to the containment surface. The material behavior of the concrete was incorporated using the damaged plasticity model while that of the reinforcement, the Johnson–Cook elasto-viscoplastic model. The containment could not sustain the impact of Boeing 747-400 and Boeing 767-400 aircrafts and suffered rupture of concrete around the impact region leading to global failure. On the other hand, the maximum local deformation at the point of impact was found to be 0.998 m, 0.099 m, 0.092 m, 0.089 m, and 0.074 m against Boeing 747-400, Phantom F4, Boeing 767, Boeing 707-320 and Airbus A-320 aircrafts respectively. The results of the present study were compared with those of the previous analytical and numerical investigations with respect to the maximum deformation and overall behavior of the containment.

  15. Strategická analýza společností Airbus a Boeing

    OpenAIRE

    Engelmajer, Tomáš

    2009-01-01

    The market for large commercial aircraft is in turn dominated by the duopoly of Airbus SAS, a division of EADS, and Boeing Commercial Airplanes, a division of The Boeing Company. My Aim is to describe the current strategic and financial situation of the two largest companies in the aerospace industry with a particular focus on the divisions supplying Large Commercial Aircraft. I describe the production of civil airliners in the whole context of the current global economic situation and the fu...

  16. Valuation of the Boeing Company

    OpenAIRE

    Khan, Mohammed Masud

    2015-01-01

    In this paper I have conducted a comprehensive analysis of the Boeing Company based on popular valuation methods to determine if the share price of Boeing is undervalued, overvalued, or correctly valued. My initial finding is that, the equity price of Boeing differs slightly from the current market price. According to the discounted cash flow analysis, a fair price of Boeing is USD 101.893 which is approximately 26 % lower than the current market price (USD 128,358 as per 31/12/2014). Rather ...

  17. Environmentamb-Col

    OpenAIRE

    2010-01-01

    Environmentamb-col es una organización privada para el tratamiento de residuos sólidos de la industria de Cundinamarca. Su propósito es mejorar la calidad del ambiente y desarrollar conciencia ecológica en la población urbana y rural. Ubicada en la cabecera del municipio de Chocontá, la organización cuenta con una planta de tratamiento de residuos, donde se recicla y separa el material desechado

  18. Will Boeing Change Health Care?

    Science.gov (United States)

    Stempniak, Marty

    2015-12-01

    Big employers like Boeing and Intel are directly contracting with hospitals in an effort to control health care prices. Some hospital CEOs see direct contracting as the future, while others wonder how they can participate.

  19. Data Mining of NASA Boeing 737 Flight Data: Frequency Analysis of In-Flight Recorded Data

    Science.gov (United States)

    Butterfield, Ansel J.

    2001-01-01

    Data recorded during flights of the NASA Trailblazer Boeing 737 have been analyzed to ascertain the presence of aircraft structural responses from various excitations such as the engine, aerodynamic effects, wind gusts, and control system operations. The NASA Trailblazer Boeing 737 was chosen as a focus of the study because of a large quantity of its flight data records. The goal of this study was to determine if any aircraft structural characteristics could be identified from flight data collected for measuring non-structural phenomena. A number of such data were examined for spatial and frequency correlation as a means of discovering hidden knowledge of the dynamic behavior of the aircraft. Data recorded from on-board dynamic sensors over a range of flight conditions showed consistently appearing frequencies. Those frequencies were attributed to aircraft structural vibrations.

  20. Northwest to Accelerate Retirement of Dc10 Aircraft

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Northwest Airlines announced that it will accelerate the retirement of its remaining 12DC10-30 aircraft in service. The airline said that during the next seven months,it will replace DC10 aircraft with new Airbus A330s and Boeing 747-400aircraft being returned to service.Currently, seven routes are served with the DC10.

  1. ASDAR (aircraft to satellite data relay) flight test report

    Science.gov (United States)

    Domino, E. J.; Lovell, R. R.; Conroy, M. J.; Culp, D. H.

    1977-01-01

    The aircraft to Satellite Data Relay (ASDAR), an airborne data collection system that gathers meteorological data from existing aircraft instrumentation and relays it to ground user via a geo-synchronous meteorological satellite, is described and the results of the first test flight on a commercial Boeing 747 aircraft are presented. The flight test was successful and verified system performance in the anticipated environment.

  2. 波音757飞机维护CBT课件的开发与研制%Development of the CBT Courseware for theManitenance of the Boeing 757 Aircraft

    Institute of Scientific and Technical Information of China (English)

    官颂

    2001-01-01

    With a brief introcuction to the concept of the CBT courseware the paper makes an exposition of the whole process of how to develop the maintenance CBT courseware for the Boeing 757 aircraft the technical difficulties and the approaches to its realization in making the multimedia software by making use of Authorware as well as the techniques of developing the multimedia courseware by using model knowledge object libraries variables and functions.%阐述了CBT课件的基本概念和波音757飞机维护CBT课件的开发制作过程,以及利用 Authorware开发软件制作多媒体课件的技术难点和实现方法,使用模板、知识对象、库、变量和函数等开发多媒体课件的技巧。

  3. Aircraft Survivability. Susceptibility Reduction. Fall 2010

    Science.gov (United States)

    2010-01-01

    to determine the degree of control available with manual manipulation of engine throttles for various transport aircraft. Simulations included...Boeing 727, 737, 747, 757, 767, 777, MD-11, MD-90, C-17, and Airbus A320 and A300 transport aircraft. Preliminary missile impact effects were...shown, for most aircraft tested, that using only manual TOC it is very difficult to make a safe runway landing due to difficulty in controlling the

  4. Approaching BOE%初识"京东方(BOE)"

    Institute of Scientific and Technical Information of China (English)

    编辑部

    2006-01-01

    @@ "京东方"是京东方科技集团股份有限公司(Bejing Orient Electron Technology Group CO., LTD)的简称,其英文名称缩写为BOE.京东方的前身是享有"中国电子工业摇篮"美誉的北京电子管厂.该厂在20世纪80年代陷入重重危机,濒临破产.

  5. 78 FR 25662 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-05-02

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for all The Boeing Company Model 727... Federal holidays. For Boeing service information identified in this proposed AD, contact Boeing...

  6. Boeing Technology Exposition & Exchange Brochure & Flyer

    OpenAIRE

    Phantom Works and Integrated Defense Systems / Advanced Systems

    2008-01-01

    Not open to the public - No foreign Nationals, Attendance Restricted by U.S. Export Regulations. The Expo is open only to Active Duty U.S. Military, U.S. GOvernment Civilian Personnel and Boeing invited Support Contractors, who are U.S. persons, will be required to sign a Proprietary Information Agreement with The Boeing Company. For more information visit: http://www.boeing.com/techexpo The documents attached include a NPS tri-fold brochure and a Tech Expo Flyer. Brochure regarding ...

  7. Flight Services and Aircraft Access: Active Flow Control Vertical Tail and Insect Accretion and Mitigation Flight Test

    Science.gov (United States)

    Whalen, Edward A.

    2016-01-01

    This document serves as the final report for the Flight Services and Aircraft Access task order NNL14AA57T as part of NASA Environmentally Responsible Aviation (ERA) Project ITD12A+. It includes descriptions of flight test preparations and execution for the Active Flow Control (AFC) Vertical Tail and Insect Accretion and Mitigation (IAM) experiments conducted on the 757 ecoDemonstrator. For the AFC Vertical Tail, this is the culmination of efforts under two task orders. The task order was managed by Boeing Research & Technology and executed by an enterprise-wide Boeing team that included Boeing Research & Technology, Boeing Commercial Airplanes, Boeing Defense and Space and Boeing Test and Evaluation. Boeing BR&T in St. Louis was responsible for overall Boeing project management and coordination with NASA. The 757 flight test asset was provided and managed by the BCA ecoDemonstrator Program, in partnership with Stifel Aircraft Leasing and the TUI Group. With this report, all of the required deliverables related to management of this task order have been met and delivered to NASA as summarized in Table 1. In addition, this task order is part of a broader collaboration between NASA and Boeing.

  8. Subsonic Ultra Green Aircraft Research

    Science.gov (United States)

    Bradley, Marty K.; Droney, Christopher K.

    2011-01-01

    This Final Report summarizes the work accomplished by the Boeing Subsonic Ultra Green Aircraft Research (SUGAR) team in Phase 1, which includes the time period of October 2008 through March 2010. The team consisted of Boeing Research and Technology, Boeing Commercial Airplanes, General Electric, and Georgia Tech. The team completed the development of a comprehensive future scenario for world-wide commercial aviation, selected baseline and advanced configurations for detailed study, generated technology suites for each configuration, conducted detailed performance analysis, calculated noise and emissions, assessed technology risks, and developed technology roadmaps. Five concepts were evaluated in detail: 2008 baseline, N+3 reference, N+3 high span strut braced wing, N+3 gas turbine battery electric concept, and N+3 hybrid wing body. A wide portfolio of technologies was identified to address the NASA N+3 goals. Significant improvements in air traffic management, aerodynamics, materials and structures, aircraft systems, propulsion, and acoustics are needed. Recommendations for Phase 2 concept and technology projects have been identified.

  9. 77 FR 58330 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-09-20

    ..., email: rse.boecom@boeing.com . The report must include the inspection results including a description of..., Attention: Manager, Airline Support, email: rse.boecom@boeing.com . The report must include the...

  10. 78 FR 52875 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2013-08-27

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; the Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for all the Boeing Company Model 727.... For service information identified in this proposed AD, contact Boeing Commercial Airplanes,...

  11. 77 FR 59728 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-10-01

    ...-125-AD; Amendment 39-17198; AD 2012-19-03] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... superseding an existing airworthiness directive (AD) for certain The Boeing Company Model DC-10-10, DC-10-10F..., August 3, 2006). ADDRESSES: For service information identified in this AD, contact Boeing...

  12. 78 FR 56182 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-09-12

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company... to rescind airworthiness directive (AD) 2008-06-03, which applies to certain The Boeing Company Model..., American Airlines, and Boeing requested clarification of the different unsafe condition introduced by...

  13. 77 FR 21426 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-04-10

    ...-020-AD; Amendment 39-17013; AD 2012-07-07] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for all The Boeing Company Model 747 airplanes. This AD was prompted..., contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707, MC...

  14. 78 FR 49217 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2013-08-13

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; the Boeing Company... directive (AD), for all The Boeing Company Model 727 airplanes, which proposed to supersede an existing AD... information identified in this AD, contact Boeing Commercial Airplanes, Attention: Data & Services...

  15. 78 FR 58982 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-09-25

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to supersede airworthiness directive (AD) 2013-07- 07, which applies to all The Boeing... information identified in this AD, contact Boeing Commercial Airplanes, Attention: Data & Services...

  16. 78 FR 49229 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-08-13

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company... Boeing Company Model 737-600, -700, - 700C, and -800 series airplanes. AD 2009-24-07 currently requires... holidays. For service information identified in this proposed AD, contact Boeing Commercial...

  17. 78 FR 58962 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-09-25

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company... Boeing Company Model 747 series airplanes. ] AD 89-12-10 currently requires replacement of certain... information identified in this proposed AD, contact Boeing Commercial Airplanes, Attention: Data &...

  18. 77 FR 12170 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-02-29

    ...-135-AD; Amendment 39-16940; AD 2012-02-17] RIN 2120-AA64 Airworthiness Directives; The Boeing Company.... ADDRESSES: For service information identified in this AD, contact Boeing Commercial Airplanes, Attention...-5000, extension 1; fax 206-766-5680; email me.boecom@boeing.com ; Internet...

  19. 77 FR 21429 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-04-10

    ...-208-AD; Amendment 39-17012; AD 2012-07-06] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 777 airplanes. This AD was...: For service information identified in this AD, contact Boeing Commercial Airplanes, Attention:...

  20. 78 FR 73460 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2013-12-06

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; the Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 767... Federal holidays. For service information identified in this proposed AD, contact Boeing...

  1. 77 FR 24835 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-04-26

    ...-217-AD; Amendment 39-17031; AD 2012-08-14] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 767 airplanes. This AD was... this AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707,...

  2. 78 FR 3365 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-01-16

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Airplanes... holidays. For service information identified in this proposed AD, contact Boeing Commercial...

  3. 78 FR 49237 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2013-08-13

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; the Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 707... Federal holidays. For service information identified in this proposed AD, contact Boeing...

  4. 78 FR 52838 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-08-27

    ...-354-AD; Amendment 39-17533; AD 2013-15-17] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 737-600, -700, -700C, -800, -900... information identified in this AD, contact Boeing Commercial Airplanes, Attention: Data & Services...

  5. 78 FR 52836 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-08-27

    ...-352-AD; Amendment 39-17529; AD 2013-15-13] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for all The Boeing Company Model 757 airplanes. This AD was prompted... October 1, 2013. ADDRESSES: For service information identified in this AD, contact Boeing...

  6. 78 FR 24037 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-04-24

    ...-257-AD; Amendment 39-17441; AD 2013-08-23] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for all The Boeing Company Model DC-10-10, DC-10-10F, DC-10-15, DC-10... Service Information Two commenters requested that we delay issuing the AD until Boeing has...

  7. 77 FR 731 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-01-06

    ...-256-AD; Amendment 39-16904; AD 2011-27-03] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... publications listed in the AD as of February 10, 2012. ADDRESSES: For Boeing service information identified in this AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707,...

  8. 77 FR 54856 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-09-06

    ... respect to maintaining fail-safe design and damage tolerance of the structure of The Boeing Company Model... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for all The Boeing Company Model 727,...

  9. 78 FR 76047 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-12-16

    ...-074-AD; Amendment 39-17695; AD 2013-24-18] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 747-200B, -200C, -200F, -300... (AD): 2013-24-18 The Boeing Company: Amendment 39-17695; Docket No. FAA- 2013-0704;...

  10. 78 FR 53078 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-08-28

    ... Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice... certain The Boeing Company Model 747-200B, -200C, -200F, -300, and 747SR series airplanes. This proposed... directive (AD): The Boeing Company: Docket No. FAA-2013-0704; Directorate Identifier 2013-NM-074-AD....

  11. 78 FR 21569 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-04-11

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for all The Boeing Company Model 727... the following new airworthiness directive (AD): The Boeing Company: Docket No....

  12. 78 FR 57053 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-09-17

    ...-243-AD; Amendment 39-17572; AD 2013-17-08] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... superseding airworthiness directive (AD) 2010-20-08, which applied to certain The Boeing Company Model 747-100... (75 ] FR 61337, October 5, 2010), and adding the following new AD: 2013-17-08 The Boeing...

  13. 78 FR 13463 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-02-28

    ...-042-AD; Amendment 39-17284; AD 2012-25-03] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... applies to certain The Boeing Company Model 757 airplanes. That AD incorrectly identified certain actions... windshield. For certain The Boeing Company Model 757 airplanes, AD 2012-25-03 also specifies...

  14. 77 FR 42962 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-07-23

    ...-255-AD; Amendment 39-17117; AD 2012-14-03] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 777-200 and -300 series... the following new airworthiness directive (AD): 2012-14-03 The Boeing Company: Amendment...

  15. 78 FR 25898 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-05-03

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company... Boeing Company Model 747 series airplanes. The existing AD currently requires inspection of the fuselage... Boeing Company Model 747 series airplanes. AD 90-23-14 superseded AD 85-17-05, Amendment 39-5123...

  16. 78 FR 28764 - Airworthiness Directives; The Boeing Company

    Science.gov (United States)

    2013-05-16

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 737-300... the following new airworthiness directive (AD): The Boeing Company: Docket No....

  17. 78 FR 27001 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-05-09

    ...-277-AD; Amendment 39-17442; AD 2013-09-01] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... superseding an existing airworthiness directive (AD) for certain The Boeing Company Model 737-200, -200C, -300...), and adding the following new AD: 2013-09-01 The Boeing Company: Amendment 39-17442; Docket No....

  18. 76 FR 78574 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2011-12-19

    ... Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice... all The Boeing Company Model 767 airplanes. This proposed AD was prompted by reports of cracks of the... fitting, and contacting The Boeing Company for repair instructions and doing the repair. The...

  19. 77 FR 23166 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-04-18

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for all The Boeing Company Model DC-10-10.... 39.13 by adding the following new airworthiness directive (AD): The Boeing Company: Docket No....

  20. 78 FR 59293 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-09-26

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 777... directive (AD): The Boeing Company: Docket No. FAA-2013-0830; Directorate Identifier 2013-NM-128-AD. ]...

  1. 77 FR 76230 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-12-27

    ...-268-AD; Amendment 39-17286; AD 2012-25-05] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 737-600, -700, -700C, -800, -900... airworthiness directive (AD): 2012-25-05 The Boeing Company: Amendment 39-17286; Docket No. FAA-...

  2. 78 FR 73744 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-12-09

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company... proposed rulemaking (SNPRM) for all The Boeing Company Model 737-600, -700, - 700C, -800, -900 and -900ER... stabilizer; hence, this SNPRM should apply to all The Boeing Company Model 737-600, -700, -700C, -800,...

  3. 77 FR 71723 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-12-04

    ... Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice... (AD) that applies to certain The Boeing Company Model 737-200, -200C, - 300, and -400 series airplanes...-13 R1, Amendment 39-12317 (66 FR 36146, July 11, 2001), for certain The Boeing Company Model...

  4. 78 FR 26233 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-05-06

    ...-17418; AD 2013-08-01] RIN 2120-AA64 Airworthiness Directives; The Boeing Company Airplanes AGENCY... airworthiness directive (AD) for certain The Boeing Company Model 737-600, -700, -700C, -800, -900, and -900ER...): 2013-08-01 The Boeing Company: Amendment 39-17418; Docket No. FAA- 2011-1231; Directorate...

  5. 78 FR 46540 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-08-01

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 747... FAA amends Sec. 39.13 by adding the following new airworthiness directive (AD): The Boeing...

  6. 78 FR 27020 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-05-09

    ... revising an existing airworthiness directive (AD) for all The Boeing Company Model 737-100, -200, -200C..., January 9, 2013) and the FAA's response to each comment. Supportive Comment The Boeing Company stated that..., 2012), and adding the following new AD: 2012-18-13 R1 The Boeing Company: Amendment 39-17429; Docket...

  7. 78 FR 4042 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-01-18

    ...-181-AD; Amendment 39-17299; AD 2012-26-04] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... superseding an existing airworthiness directive (AD) for certain The Boeing Company Model 757-200, -200PF, and...), and adding the following new AD: 2012-26-04 The Boeing Company: Amendment 39-17299; Docket No....

  8. 77 FR 61550 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-10-10

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company... would have superseded an existing AD that applies to certain The Boeing Company Model 737-200, -200C... FR 54206, September 8, 2004), and adding the following new AD: The Boeing Company: Docket No....

  9. 78 FR 4047 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-01-18

    ...-029-AD; Amendment 39-17295; AD 2012-25-13] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 747-100, 747-200B, 747-200C, 747... The Boeing Company: Amendment 39-17295; Docket No. FAA- 2012-0299; Directorate Identifier...

  10. 78 FR 40060 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-07-03

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company... Boeing Company Model 777-200 and -300 series airplanes equipped with Rolls-Royce engines. The existing AD... 2006-26-06, Amendment 39-14864 (71 FR 77586, December 27, 2006), for certain The Boeing Company...

  11. 78 FR 37497 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-06-21

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company... to rescind an existing airworthiness directive (AD) that applies to certain The Boeing Company Model...'s response. Requests To Clarify ``Different Unsafe Condition'' UPS and Boeing...

  12. 77 FR 49708 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-08-17

    ...-066-AD; Amendment 39-17159; AD 2012-16-12] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for all The Boeing Company Model 707 airplanes, and Model 720 and... airworthiness directive (AD): 2012-16-12 The Boeing Company: Amendment 39-17159; Docket No. FAA-...

  13. 77 FR 47329 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-08-08

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company... propose to rescind an existing airworthiness directive (AD) that applies to certain The Boeing Company...), for certain The Boeing Company Model 767-200, -300, -300F, and -400ER series airplanes. That...

  14. 78 FR 68345 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-11-14

    ...-187-AD; Amendment 39-17658; AD 2013-23-03] RIN 2120-AA64 Airworthiness Directives; The Boeing Company.... SUMMARY: We are adopting a new airworthiness directive (AD) for certain The Boeing Company Model 747-100....13 by adding the following new airworthiness directive (AD): 2013-23-03 The Boeing Company:...

  15. 77 FR 34876 - Airworthiness Directives; The Boeing Company

    Science.gov (United States)

    2012-06-12

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 777.... 39.13 by adding the following new airworthiness directive (AD): The Boeing Company: Docket No....

  16. 77 FR 24355 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-04-24

    ...-265-AD; Amendment 39-17026; AD 2012-08-09] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 777-200, -200LR, -300, -300ER... to The Boeing Company Model 777-200, -200LR, - 300, -300ER, and 777F series airplanes,...

  17. 77 FR 51724 - Airworthiness Directives; The Boeing Company

    Science.gov (United States)

    2012-08-27

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company... directive (AD) for certain The Boeing Company Model 737-600, -700, -700C, -800, - 900, and -900ER series... apply to certain The Boeing Company Model 737-600, -700, -700C, - 800, -900, and -900ER series...

  18. 78 FR 4051 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-01-18

    ... superseding an existing airworthiness directive (AD) for certain The Boeing Company Model 747-100, 747-100B..., 2009), and adding the following new AD: 2013-01-02 The Boeing Company: Amendment 39-17316; Docket No...-16059 (74 FR 55763, October 29, 2009). (c) Applicability This AD applies to The Boeing Company Model...

  19. 77 FR 41041 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-07-12

    ...-17111; AD 2012-13-09] RIN 2120-AA64 Airworthiness Directives; The Boeing Company Airplanes AGENCY... airworthiness directive (AD) for certain The Boeing Company Model 747-100, 747-100B, 747-100B SUD, 747-200B, 747...): 2012-13-09 The Boeing Company: Amendment 39-17111; Docket No. FAA- 2010-1115; Directorate...

  20. 78 FR 43839 - Airworthiness Directives; the Boeing Company

    Science.gov (United States)

    2013-07-22

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; the Boeing Company..., 1994), and adding the following new AD: The Boeing Company: Docket No. FAA-2013-0625; Directorate..., 1994). (c) Applicability This AD applies to The Boeing Company Model 747-100, 747-200B, and...

  1. 77 FR 46340 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-08-03

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company... FR 71212, December 17, 2007), and adding the following new AD: The Boeing Company: Docket No. FAA... 39-15307 (72 FR 71212, December 17, 2007). (c) Applicability This AD applies to The Boeing...

  2. 78 FR 46532 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2013-08-01

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; the Boeing Company... directive (AD) for all The Boeing Company Model 767 airplanes. That NPRM proposed to require repetitive... directive (AD): The Boeing Company: Docket No. FAA-2008-0616; Directorate Identifier 2007-NM-353-AD....

  3. 78 FR 21576 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-04-11

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 757... directive (AD): The Boeing Company: Docket No. FAA-2013-0300; Directorate Identifier 2011-NM-163-AD....

  4. 78 FR 12231 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-02-22

    ...-016-AD; Amendment 39-17366; AD 2013-02-51] RIN 2120-AA64 Airworthiness Directives; The Boeing Company.... SUMMARY: We are adopting a new airworthiness directive (AD) for all The Boeing Company Model 787-8... airworthiness directive (AD): 2013-02-51 The Boeing Company: Amendment 39-17366; Docket No. FAA-...

  5. 77 FR 43547 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-07-25

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 737... amends Sec. 39.13 by adding the following new airworthiness directive (AD): The Boeing Company: Docket...

  6. 78 FR 55662 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2013-09-11

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; the Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain the Boeing Company Model DC-9.... 39.13 by adding the following new airworthiness directive (AD): The Boeing Company: Docket No....

  7. 78 FR 35749 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-06-14

    ...-151-AD; Amendment 39-17474; AD 2013-11-14] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 777-200 and -300 series...): 2013-11-14 The Boeing Company: Amendment 39-17474; Docket No. FAA- 2012-1221; Directorate...

  8. 78 FR 25905 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-05-03

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 727... the following new airworthiness directive (AD): The Boeing Company: Docket No....

  9. 78 FR 68693 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-11-15

    ...-087-AD; Amendment 39-17659; AD 2013-23-04] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 737-600, -700, -800, -900, and...): 2013-23-04 The Boeing Company: Amendment 39-17659; Docket No. FAA- 2012-0426; Directorate...

  10. 78 FR 57542 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-09-19

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company... Boeing Company Model 777-200 and -300 series airplanes. AD 2012-12-08 requires an inspection for the part..., 2012) (``AD 2012-12-08''), for certain The Boeing Company Model 777-200 and -300 series airplanes....

  11. 78 FR 73739 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-12-09

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company... all The Boeing Company Model MD-90- 30 airplanes. AD 97-11-07 and AD 99-18-23 currently require..., 1997), for all The Boeing Company Model MD-90-30 airplanes. AD 97-11-07 requires revising...

  12. 77 FR 33619 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-06-07

    ...-087-AD; Amendment 39-17074; AD 2012-11-11] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... superseding an existing airworthiness directive (AD) for certain The Boeing Company Model 767-200, -300, and... (74 FR 8717, February 26, 2009), and adding the following new AD: 2012-11-11 The Boeing...

  13. 77 FR 40307 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-07-09

    ... Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... earlier proposed airworthiness directive (AD) for certain The Boeing Company Model 747-400, -400D, and... directive (AD): The Boeing Company: Docket No. FAA-2008-0620; Directorate Identifier 2007-NM-357-AD....

  14. 78 FR 72836 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-12-04

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for all The Boeing Company Model 717-200... FAA amends Sec. 39.13 by adding the following new airworthiness directive (AD): The Boeing...

  15. 77 FR 55159 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-09-07

    ... Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... earlier proposed airworthiness directive (AD) for certain The Boeing Company Model 737-700, -700C, -800... certain The Boeing Company Model 737-700, -700C, -800, and -900ER series airplanes, Model 747-400F...

  16. 78 FR 78703 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-12-27

    ...-067-AD; Amendment 39-17708; AD 2013-25-12] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model DC-9-10, DC-9-30, and DC-9-40... The Boeing Company: Amendment 39-17708; Docket No. FAA-2013-0706; Directorate Identifier...

  17. 77 FR 24831 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-04-26

    ...-148-AD; Amendment 39-17034; AD 2012-08-17] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 737-100, -200, -200C, -300, -400... airworthiness directive (AD): 2012-08-17 The Boeing Company: Amendment 39-17034; Docket No. FAA-...

  18. 77 FR 6518 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-02-08

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 777... directive (AD): The Boeing Company: Docket No. FAA-2012-0104; Directorate Identifier 2011-NM-279-AD....

  19. 77 FR 61548 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-10-10

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 727... directive (AD): The Boeing Company: Docket No. FAA-2012-1041; Directorate Identifier 2011-NM-272-AD....

  20. 77 FR 6522 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-02-08

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 777... directive (AD): The Boeing Company: Docket No. FAA-2012-0105; Directorate Identifier 2011-NM-123-AD....

  1. 77 FR 24357 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-04-24

    ...-002-AD; Amendment 39-17030; AD 2012-08-13] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 777-200 and -300 series... Boeing Company and United Airlines both support the NPRM (76 FR 68366, November 4, 2011). Request...

  2. 78 FR 21854 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-04-12

    ... Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice... certain The Boeing Company Model 747-400 and -400F series airplanes. This proposed AD was prompted by a... FAA amends Sec. 39.13 by adding the following new airworthiness directive (AD): The Boeing...

  3. 78 FR 20229 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-04-04

    ...-119-AD; Amendment 39-17402; AD 2013-06-05] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... superseding an existing airworthiness directive (AD) for all The Boeing Company Model 737-600, -700, -700C... AD: 2013-06-05 The Boeing Company: Amendment 39-17402; Docket No. FAA- 2012-0994;...

  4. 77 FR 41045 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-07-12

    ...-279-AD; Amendment 39-17107; AD 2012-13-05] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 777-200, -200LR, -300, -300ER... airworthiness directive (AD): 2012-13-05 The Boeing Company: Amendment 39-17107; Docket No. FAA-...

  5. 78 FR 28128 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2013-05-14

    ...-351-AD; Amendment 39-17450; AD 2013-09-08] RIN 2120-AA64 Airworthiness Directives; the Boeing Company... new airworthiness directive (AD) for all The Boeing Company Model 737-300, -400, and -500 series... the Boeing Company: Amendment 39-17450; Docket No. FAA- 2008-0614; Directorate Identifier...

  6. 78 FR 78701 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-12-27

    ...-003-AD; Amendment 39-17701; AD 2013-25-05] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 737-300, -400, and -500 series... airworthiness directive (AD): 2013-25-05 The Boeing Company: Amendment 39-17701; Docket No. FAA-...

  7. 77 FR 42964 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-07-23

    ...-103-AD; Amendment 39-17095; AD 2012-12-15] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... superseding an existing airworthiness directive (AD) for The Boeing Company Model 757 Airplanes. That AD... (73 FR 25974, May 8, 2008), and adding the following new AD: 2012-12-15 The Boeing Company:...

  8. 77 FR 75827 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-12-26

    ...-190-AD; Amendment 39-17292; AD 2012-25-11] RIN 2120-AA64 Airworthiness Directives; The Boeing Company.... SUMMARY: We are superseding an existing airworthiness directive (AD) for certain The Boeing Company Model... certain The Boeing Company Model 757-200, -200CB, and -300 series airplanes. AD 2012-15-15...

  9. 77 FR 65506 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-10-29

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company... Boeing Company Model 757-200 and - 200PF series airplanes. The existing AD currently requires... 11, 2003), and adding the following new AD: The Boeing Company: Docket No. FAA-2012-1109;...

  10. 77 FR 11789 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-02-28

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 737.... 39.13 by adding the following new airworthiness directive (AD): The Boeing Company: Docket No....

  11. 78 FR 26286 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-05-06

    ... airworthiness directive (AD) for all The Boeing Company Model 717-200 airplanes. That NPRM proposed requiring... rulemaking (NPRM) to amend 14 CFR part 39 to include an AD that would apply to all The Boeing Company Model... directive (AD): The Boeing Company: Docket No. FAA-2012-0425; Directorate Identifier 2011-NM-273-AD....

  12. 78 FR 4055 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-01-18

    ...-130-AD; Amendment 39-17317; AD 2013-01-03] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 737-300, 737-400, 737-500, and... airworthiness directive (AD): 2013-01-03 The Boeing Company: Amendment 39-17317; Docket No. ]...

  13. 77 FR 31167 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-05-25

    ...-17059; AD 2012-10-10] RIN 2120-AA64 Airworthiness Directives; The Boeing Company Airplanes AGENCY... airworthiness directive (AD) for certain The Boeing Company Model 777 airplanes. This AD was prompted by reports... airworthiness directive (AD): 2012-10-10 The Boeing Company: Amendment 39-17059; Docket No. FAA-...

  14. 78 FR 14469 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-03-06

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company... Boeing Company Model 747-100, 747- 100B, 747-100B SUD, 747-200B, 747-200C, 747-200F, 747-300, 747-400... 61337, October 5, 2010), and adding the following new AD: The Boeing Company: Docket No....

  15. 77 FR 71485 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-12-03

    ... adopting a new airworthiness directive (AD) for certain The Boeing Company Model 737-100, -200, -200C, -300... airworthiness directive (AD): 2012-23-14 The Boeing Company: Amendment 39-17270; Docket No. FAA- 2012-0857... ADs None. (c) Applicability (1) This AD applies to The Boeing Company Model 737-100, -200, -...

  16. 77 FR 29857 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-05-21

    ...-009-AD; Amendment 39-17052; AD 2012-10-03] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... superseding an existing airworthiness directive (AD) for certain The Boeing Company Model 747 series airplanes... following new AD: 2012-10-03 The Boeing Company: Amendment 39-17052; Docket No. FAA- 2011-0645;...

  17. 78 FR 6202 - Airworthiness Directives; the Boeing Company

    Science.gov (United States)

    2013-01-30

    ...-191-AD; Amendment 39-17326; AD 2013-02-05] RIN 2120-AA64 Airworthiness Directives; the Boeing Company... airworthiness directive (AD) for certain The Boeing Company Model 737-600, -700, -700C, -800, -900, and -900ER...): 2013-02-05 The Boeing Company: Amendment 39-17326; Docket No. FAA-2011-0258; Directorate...

  18. 77 FR 48423 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-08-14

    ...-213-AD; Amendment 39-17154; AD 2012-16-07] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 737-500 series airplanes. This... The Boeing Company: Amendment 39-17154; Docket No. FAA- 2012-0336; Directorate Identifier...

  19. 77 FR 60296 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-10-03

    ...-074-AD; Amendment 39-17206; AD 2012-19-11] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 737 airplanes. This AD was... the Latest Service Information Delta (DAL), AAL, and The Boeing Company requested that the proposed...

  20. 77 FR 22686 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-04-17

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 737.... 39.13 by adding the following new airworthiness directive (AD): The Boeing Company: Docket No....

  1. 77 FR 47267 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-08-08

    ...-17142; AD 2012-15-13] RIN 2120-AA64 Airworthiness Directives; The Boeing Company Airplanes AGENCY... following new AD: 2012-15-13 The Boeing Company: Amendment 39-17142; Docket No. FAA- 2009-0607; Directorate..., 2007). (c) Applicability This AD applies to all The Boeing Company Model 747-100B SUD, 747-300,...

  2. 78 FR 15332 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-03-11

    ... Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice... (AD) that applies to all The Boeing Company Model 737-300, -400, and - 500 series airplanes. The... (73 FR 15397, March 24, 2008), for all The Boeing Company Model 737-300, - 400, and -500...

  3. 78 FR 63130 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-10-23

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 777F.... 39.13 by adding the following new airworthiness directive (AD): The Boeing Company: Docket No....

  4. Advanced composite elevator for Boeing 727 aircraft, volume 2

    Science.gov (United States)

    Chovil, D. V.; Grant, W. D.; Jamison, E. S.; Syder, H.; Desper, O. E.; Harvey, S. T.; Mccarty, J. E.

    1980-01-01

    Preliminary design activity consisted of developing and analyzing alternate design concepts and selecting the optimum elevator configuration. This included trade studies in which durability, inspectability, producibility, repairability, and customer acceptance were evaluated. Preliminary development efforts consisted of evaluating and selecting material, identifying ancillary structural development test requirements, and defining full scale ground and flight test requirements necessary to obtain Federal Aviation Administration (FAA) certification. After selection of the optimum elevator configuration, detail design was begun and included basic configuration design improvements resulting from manufacturing verification hardware, the ancillary test program, weight analysis, and structural analysis. Detail and assembly tools were designed and fabricated to support a full-scope production program, rather than a limited run. The producibility development programs were used to verify tooling approaches, fabrication processes, and inspection methods for the production mode. Quality parts were readily fabricated and assembled with a minimum rejection rate, using prior inspection methods.

  5. Aircraft noise prediction

    Science.gov (United States)

    Filippone, Antonio

    2014-07-01

    This contribution addresses the state-of-the-art in the field of aircraft noise prediction, simulation and minimisation. The point of view taken in this context is that of comprehensive models that couple the various aircraft systems with the acoustic sources, the propagation and the flight trajectories. After an exhaustive review of the present predictive technologies in the relevant fields (airframe, propulsion, propagation, aircraft operations, trajectory optimisation), the paper addresses items for further research and development. Examples are shown for several airplanes, including the Airbus A319-100 (CFM engines), the Bombardier Dash8-Q400 (PW150 engines, Dowty R408 propellers) and the Boeing B737-800 (CFM engines). Predictions are done with the flight mechanics code FLIGHT. The transfer function between flight mechanics and the noise prediction is discussed in some details, along with the numerical procedures for validation and verification. Some code-to-code comparisons are shown. It is contended that the field of aircraft noise prediction has not yet reached a sufficient level of maturity. In particular, some parametric effects cannot be investigated, issues of accuracy are not currently addressed, and validation standards are still lacking.

  6. Modern trends of aircraft fly-by-wire systems

    Directory of Open Access Journals (Sweden)

    С. С. Юцкевич

    2013-07-01

    Full Text Available Specifics of civil aviation modern transport aircraft fly-by-wire control systems are described. A comparison of the systems-level hardware and software, expressed through modes of guidance, provision of aircraft Airbus A-320, Boeing B-777, Tupolev Tu-214, Sukhoi Superjet SSJ-100 are carried out. The possibility of transition from mechanical control wiring to control through fly-by-wire system in the backup channel is shown.

  7. SUPPLY CHAIN FEATURES OF THE AEROSPACE INDUSTRY PARTICULAR CASE AIRBUS AND BOEING

    Directory of Open Access Journals (Sweden)

    Daniela MOCENCO

    2015-10-01

    Full Text Available Aerospace sector is one of the most globalized industries in terms of market structure and production system. Through aircraft development programs aviation industry has introduced new solutions to develop its products. The role of the partners involved in the development programs for the new generation aircraft is becoming increasingly important. Supply chain management has become a key factor for major manufacturers in the industry. The new strategies introduced by the aircraft manufacturers have increased the complexity of the supply process, design and production from the aviation industry. This paper highlights a series of factors regarding the aircraft programs supply chain management. In the first part are described the problems encountered by the manufacturers and airlines during the development of the most recent aircraft launched A350XWB and B787 Dreamliner; the second part focuses on the organizational structure of the supply chain, suppliers role within supply chain and also there are described the effects of the new strategies adopted by Airbus and Boeing in the aircraft development; the last part focuses on the risks and challenges that aviation industry is facing.

  8. Air Canada Selects Boeing 777s and 787 Dreamliners

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

      ACE Aviation Holdings Inc.,the parent company of Air Canada, and Boeing today announced a wide-body fleet renewal plan for the airline that includes up to 36 Boeing 777s and up to 60 Boeing 787Dreamliners. Air Canada will use the airplanes to modernize its existing fleet and improve operating efficiencies, creating one of the world's youngest and most simplified airline fleets.……

  9. Air Canada Selects Boeing 777s and 787 Dreamliners

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ ACE Aviation Holdings Inc.,the parent company of Air Canada, and Boeing today announced a wide-body fleet renewal plan for the airline that includes up to 36 Boeing 777s and up to 60 Boeing 787Dreamliners. Air Canada will use the airplanes to modernize its existing fleet and improve operating efficiencies, creating one of the world's youngest and most simplified airline fleets.

  10. 78 FR 15281 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-03-11

    ... adopting a new airworthiness directive (AD) for all The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD... airworthiness directive (AD): 2013-05-02 The Boeing Company: Amendment 39-17374; Docket No. FAA- 2011-0909... ADs None. (c) Applicability This AD applies to The Boeing Company Model DC-9-81 (MD-81), DC- 9-82...

  11. 77 FR 46343 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-08-03

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company... Boeing Company Model 747-100, 747-100B, 747-100B SUD, 747-200B, 747-200C, 747-200F, 747-300, 747-400, 747... 2009-22-08, Amendment 39-16059 (74 FR 55763, October 29, 2009), for certain The Boeing Company...

  12. Boeing's variable geometry chevron: morphing aerospace structures for jet noise reduction

    Science.gov (United States)

    Calkins, Frederick T.; Mabe, James H.; Butler, George W.

    2006-03-01

    Boeing is applying cutting edge smart material actuators to the next generation morphing technologies for aircraft. This effort has led to the Variable Geometry Chevrons (VGC), which utilize compact, light weight, and robust shape memory alloy (SMA) actuators. These actuators morph the shape of chevrons on the trailing edge of a jet engine in order to optimize acoustic and performance objectives at multiple flight conditions. We have demonstrated a technical readiness level of 7 by successfully flight testing the VGCs on a Boeing 777-300ER with GE-115B engines. In this paper we describe the VGC design, development and performance during flight test. Autonomous operation of the VGCs, which did not require a control system or aircraft power, was demonstrated. A parametric study was conducted showing the influence of VGC configurations on shockcell generated cabin noise reduction during cruise. The VGC system provided a robust test vehicle to explore chevron configurations for community and shockcell noise reduction. Most importantly, the VGC concept demonstrated an exciting capability to optimize jet nozzle performance at multiple flight conditions.

  13. Capacity assessment of concrete containment vessels subjected to aircraft impact

    Energy Technology Data Exchange (ETDEWEB)

    Andonov, Anton, E-mail: anton.andonov@mottmac.com; Kostov, Marin; Iliev, Alexander

    2015-12-15

    Highlights: • An approach to assess the containment capacity to aircraft impact via fragility curves is proposed. • Momentum over Area was defined as most suitable reference parameter to describe the aircraft load. • The effect of the impact induced damages on the containment pressure capacity has been studied. • The studied containment shows no reduction of the pressure capacity for the investigated scenarios. • The effectiveness of innovative protective structure against aircraft impact has been evaluated. - Abstract: The paper describes the procedure and the results from the assessment of the vulnerability of a generic pre-stressed containment structure subjected to a large commercial aircraft impact. Impacts of Boeing 737, Boeing 767 and Boeing 747 have been considered. The containment vulnerability is expressed by fragility curves based on the results of a number of nonlinear dynamic analyses. Three reference parameters have been considered as impact intensity measure in the fragility curve definition: peak impact force (PIF), peak impact pressure (PIP) and Momentum over Area (MoA). Conclusions on the most suitable reference parameter as well on the vulnerability of such containment vessels are drawn. The influence of the aircraft impact induced damages on the containment ultimate pressure capacity is also assessed and some preliminary conclusions on this are drawn. The paper also addresses a conceptual design of a protective structure able to decrease the containment vulnerability and provide a preliminary assessment of the applicability of such concept.

  14. Design and Test of a Blast Shield for Boeing 737 Overhead Compartment

    Directory of Open Access Journals (Sweden)

    Xinglai Dang

    2006-01-01

    Full Text Available This work demonstrates the feasibility of using a composite blast shield for hardening an overhead bin compartment of a commercial aircraft. If a small amount of explosive escapes detection and is brought onboard and stowed in an overhead bin compartment of a passenger aircraft, the current bins provide no protection against a blast inside the compartment. A blast from the overhead bin will certainly damage the fuselage and likely lead to catastrophic inflight structural failure. The feasibility of using an inner blast shield to harden the overhead bin compartment of a Boeing 737 aircraft to protect the fuselage skin in such a threat scenario has been demonstrated using field tests. The blast shield was constructed with composite material based on the unibody concept. The design was carried out using LS-DYNA finite element model simulations. Material panels were first designed to pass the FAA shock holing and fire tests. The finite element model included the full coupling of the overhead bin with the fuselage structure accounting for all the different structural connections. A large number of iterative simulations were carried out to optimize the fiber stacking sequence and shield thickness to minimize weight and achieve the design criterion. Three designs, the basic, thick, and thin shields, were field-tested using a frontal fuselage section of the Boeing 737–100 aircraft. The basic and thick shields protected the integrity of the fuselage skin with no skin crack. This work provides very encouraging results and useful data for optimization implementation of the blast shield design for hardening overhead compartments against the threat of small explosives.

  15. 78 FR 73457 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2013-12-06

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; the Boeing Company... Boeing Company Model 747-100, 747-200B, 747-200F series airplanes. AD 84-19-01 requires repetitive... Friday, except Federal holidays. For service information identified in this proposed AD, contact...

  16. 78 FR 11972 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-02-21

    ...-077-AD; Amendment 39-17362; AD 2013-04-05] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 737-200, -200C, -300, -400, and... the AD as of March 28, 2013. ADDRESSES: For service information identified in this AD, contact...

  17. 78 FR 26720 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-05-08

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company... Boeing Company Model 747-100, 747- 100B, 747-100B SUD, 747-200B, 747-200C, 747-300, 747-400, 747-400D... Friday, except Federal holidays. For service information identified in this proposed AD, contact...

  18. 78 FR 27315 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-05-10

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for all The Boeing Company Model 757... Friday, except Federal holidays. For service information identified in this proposed AD, contact...

  19. 77 FR 58325 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-09-20

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 737... Friday, except Federal holidays. For service information identified in this proposed AD, contact...

  20. 78 FR 24673 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-04-26

    ...-080-AD; Amendment 39-17436; AD 2013-08-12] RIN 2120-AA64 Airworthiness Directives; The Boeing Company.... SUMMARY: We are superseding an existing airworthiness directive (AD) for The Boeing Company Model 787-8... through Friday, except Federal holidays. For service information identified in this AD, contact...

  1. 78 FR 75512 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-12-12

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 737... Friday, except Federal holidays. For service information identified in this proposed AD, contact...

  2. 78 FR 31867 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-05-28

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 747... Friday, except Federal holidays. For service information identified in this proposed AD, contact...

  3. 77 FR 58334 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-09-20

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 737... Friday, except Federal holidays. For service information identified in this proposed AD, contact...

  4. 77 FR 37770 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-06-25

    .... Request To Clarify the Applicability Regarding the Installation of Winglets American Airlines (American... for airplanes covered by the applicability of the NPRM are affected by the installation of winglets... winglets. Aviation Partners Boeing (APB) stated it has reviewed Boeing Alert Service Bulletin...

  5. With US$5 Billion,China Purchases 42 Boeing Planes

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ On August 8, Air China, China Eastern Airlines, Shanghai Airlines, Xiamen Airlines signed the final Purchase agreement of 42 Boeing planes with Boeing. The price in catalogue is US$5.04 billion. The first plane will be delivered in 2008.

  6. With US$5 Billion,China Purchases 42 Boeing Planes

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

      On August 8, Air China, China Eastern Airlines, Shanghai Airlines, Xiamen Airlines signed the final Purchase agreement of 42 Boeing planes with Boeing. The price in catalogue is US$5.04 billion. The first plane will be delivered in 2008.……

  7. 77 FR 46943 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-08-07

    ... thread between ST Aerospace and The Boeing Company was forwarded to the FAA by The Boeing Company as an.... \\1\\ Depending on work package. Authority for This Rulemaking Title 49 of the United States Code... Code 25, Equipment/Furnishings. (e) Unsafe Condition This AD was prompted by a report of an...

  8. 78 FR 60679 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-10-02

    ...-273-AD; Amendment 39-17604; AD 2013-19-22] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for all The Boeing Company Model 717-200 airplanes. This AD was... result in damage to the adjacent structure and consequent loss of structural integrity of the...

  9. 77 FR 54848 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-09-06

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 737... not electrically bonded to primary structure of the airplane. This proposed AD would...

  10. 78 FR 17290 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-03-21

    ...-056-AD; Amendment 39-17375; AD 2013-05-03] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 777-200, -200LR, -300, and... measuring the electrical resistance of the bond from the adapter plate to the airplane structure, and...

  11. 77 FR 69744 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-11-21

    ... NPRM (76 FR 69685, November 9, 2011) to clarify that structural inspections of fuselage structure are...-239-AD; Amendment 39-17255; AD 2012-22-17] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 767-200 and -300...

  12. 77 FR 50414 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-08-21

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 737... structure, which could result in uncontrolled decompression of the airplane. DATES: We must receive...

  13. 77 FR 40481 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-07-10

    ...-134-AD; Amendment 39-17110; AD 2012-13-08] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... superseding an existing airworthiness directive (AD) for certain The Boeing Company Model 747-100, 747-100B... of each affected tension tie and of the surrounding structure, and related investigative...

  14. 77 FR 37793 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2012-06-25

    ...-124-AD; Amendment 39-17099; AD 2012-12-19] RIN 2120-AA64 Airworthiness Directives; the Boeing Company... new airworthiness directive (AD) for certain the Boeing Company Model 777-200, -200LR, and -300ER... ceiling support structure of Section 41, in airplanes incorporating the overhead space utilization...

  15. 78 FR 52419 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-08-23

    ...-128-AD; Amendment 39-17555; AD 2013-16-17] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for all The Boeing Company Model 727, 727C, 727-100, 727-100C, 727... any cracked structure. We are issuing this AD to detect and correct fatigue cracking of the...

  16. 78 FR 49906 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-08-16

    ...-026-AD; Amendment 39-17527; AD 2013-15-11] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for all The Boeing Company Model 727 airplanes. This AD was prompted... structure and result in loss of airplane control due to lack of horizontal stabilizer support. DATES:...

  17. 77 FR 65803 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-10-31

    ...-050-AD; Amendment 39-17234; AD 2012-21-18] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model MD-90-30 airplanes. This AD was... AD to detect and correct such cracking, which could result in the wing structure not supporting...

  18. 77 FR 65611 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-10-30

    ...-17229; AD 2012-21-13] RIN 2120-AA64 Airworthiness Directives; The Boeing Company Airplanes AGENCY... airworthiness directive (AD) for certain The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD... result in the wing structure not supporting the limit load condition, which could lead to loss...

  19. 77 FR 45515 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-08-01

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model MD-90... could result in the wing structure not supporting the limit load condition, which could lead to loss...

  20. 78 FR 17294 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-03-21

    ...-054-AD; Amendment 39-17377; AD 2013-05-05] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 777-200, -200LR, -300, and... smoke and heat damage to airplane structure and equipment during ground operations, and...

  1. 78 FR 59304 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-09-26

    ... the following new airworthiness directive (AD): The Boeing Company: Docket No. FAA-2013-0831...) Affected ADs None. (c) Applicability This AD applies to The Boeing Company Model 737-100, -200, - 200C... TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The...

  2. 77 FR 65501 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-10-29

    ... certain The Boeing Company Model 707 airplanes, and Model 720 and 720B series airplanes. The existing AD... Boeing Company Model 707-100 long body, - 200, -100B long body, and -100B short body series airplanes... TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The...

  3. 77 FR 47330 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-08-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company... to supersede an existing airworthiness directive (AD) that applies to certain The Boeing...

  4. 78 FR 63135 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-10-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company... a new airworthiness directive (AD) for certain The Boeing Company Model 767 airplanes equipped...

  5. Aircraft landing using GPS

    Science.gov (United States)

    Lawrence, David Gary

    The advent of the Global Positioning System (GPS) is revolutionizing the field of navigation. Commercial aviation has been particularly influenced by this worldwide navigation system. From ground vehicle guidance to aircraft landing applications, GPS has the potential to impact many areas of aviation. GPS is already being used for non-precision approach guidance; current research focuses on its application to more critical regimes of flight. To this end, the following contributions were made: (1) Development of algorithms and a flexible software architecture capable of providing real-time position solutions accurate to the centimeter level with high integrity. This architecture was used to demonstrate 110 automatic landings of a Boeing 737. (2) Assessment of the navigation performance provided by two GPS-based landing systems developed at Stanford, the Integrity Beacon Landing System, and the Wide Area Augmentation System. (3) Preliminary evaluation of proposed enhancements to traditional techniques for GPS positioning, specifically, dual antenna positioning and pseudolite augmentation. (4) Introduction of a new concept for positioning using airport pseudolites. The results of this research are promising, showing that GPS-based systems can potentially meet even the stringent requirements of a Category III (zero visibility) landing system. Although technical and logistical hurdles still exist, it is likely that GPS will soon provide aircraft guidance in all phases of flight, including automatic landing, roll-out, and taxi.

  6. KC-46 Tanker Aircraft: Program Generally on Track, but Upcoming Schedule Remains Challenging

    Science.gov (United States)

    2014-04-01

    10 Currently, Air Force fixed- wing aircraft refuel with the “flying boom.” The boom is a rigid, telescoping tube that an operator on the tanker...related to aerial refueling—the centerline drogue system and wing aerial refueling pod. Boeing still considers the instability of these components to be

  7. Col11a1 Regulates Bone Microarchitecture during Embryonic Development

    Directory of Open Access Journals (Sweden)

    Anthony Hafez

    2015-12-01

    Full Text Available Collagen XI alpha 1 (Col11a1 is an extracellular matrix molecule required for embryonic development with a role in both nucleating the formation of fibrils and regulating the diameter of heterotypic fibrils during collagen fibrillar assembly. Although found in many different tissues throughout the vertebrate body, Col11a1 plays an essential role in endochondral ossification. To further understand the function of Col11a1 in the process of bone formation, we compared skeletal mineralization in wild-type (WT mice and Col11a1-deficient mice using X-ray microtomography (micro-CT and histology. Changes in trabecular bone microstructure were observed and are presented here. Additionally, changes to the periosteal bone collar of developing long bones were observed and resulted in an increase in thickness in the case of Col11a1-deficient mice compared to WT littermates. Vertebral bodies were incompletely formed in the absence of Col11a1. The data demonstrate that Col11a1 depletion results in alteration to newly-formed bone and is consistent with a role for Col11a1 in mineralization. These findings indicate that expression of Col11a1 in the growth plate and perichondrium is essential for trabecular bone and bone collar formation during endochondral ossification. The observed changes to mineralized tissues further define the function of Col11a1.

  8. Final Technical Report. Project Boeing SGS

    Energy Technology Data Exchange (ETDEWEB)

    Bell, Thomas E. [The Boeing Company, Seattle, WA (United States)

    2014-12-31

    Boeing and its partner, PJM Interconnection, teamed to bring advanced “defense-grade” technologies for cyber security to the US regional power grid through demonstration in PJM’s energy management environment. Under this cooperative project with the Department of Energy, Boeing and PJM have developed and demonstrated a host of technologies specifically tailored to the needs of PJM and the electric sector as a whole. The team has demonstrated to the energy industry a combination of processes, techniques and technologies that have been successfully implemented in the commercial, defense, and intelligence communities to identify, mitigate and continuously monitor the cyber security of critical systems. Guided by the results of a Cyber Security Risk-Based Assessment completed in Phase I, the Boeing-PJM team has completed multiple iterations through the Phase II Development and Phase III Deployment phases. Multiple cyber security solutions have been completed across a variety of controls including: Application Security, Enhanced Malware Detection, Security Incident and Event Management (SIEM) Optimization, Continuous Vulnerability Monitoring, SCADA Monitoring/Intrusion Detection, Operational Resiliency, Cyber Range simulations and hands on cyber security personnel training. All of the developed and demonstrated solutions are suitable for replication across the electric sector and/or the energy sector as a whole. Benefits identified include; Improved malware and intrusion detection capability on critical SCADA networks including behavioral-based alerts resulting in improved zero-day threat protection; Improved Security Incident and Event Management system resulting in better threat visibility, thus increasing the likelihood of detecting a serious event; Improved malware detection and zero-day threat response capability; Improved ability to systematically evaluate and secure in house and vendor sourced software applications; Improved ability to continuously monitor

  9. Engineering student takes third place in Boeing competition

    OpenAIRE

    Nystrom, Lynn A.

    2010-01-01

    Onur Bilgen of Ankara, Turkey, a recent Ph.D. recipient in the mechanical engineering department at Virginia Tech, has won third place in the Boeing competition for Engineering Student of the Year 2010.

  10. 77 FR 70355 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-11-26

    ... Federal Regulations is sold by the Superintendent of Documents. #0;Prices of new books are listed in the... the airline or by Boeing engineering, could either be approved by the Manager of the Seattle...

  11. Boeing's Marc Sheffler receives College of Engineering Service Award

    OpenAIRE

    Nystrom, Lynn A.

    2009-01-01

    In 2007, Marc Sheffler arranged for his company, Boeing, to present a $50,000 check to the Design Team Endowment Fund, founded by the Student Engineers' Council at Virginia Tech. A few months later he supplemented that check with another $15,000 check from Boeing for the same cause. In 2009, he presented the Student Engineers' Council with yet another $20,000 for the Design Team Endowment.

  12. Boeing infrared sensor (BIRS) calibration facility

    Science.gov (United States)

    Hazen, John D.; Scorsone, L. V.

    1990-01-01

    The Boeing Infrared Sensor (BIRS) Calibration Facility represents a major capital investment in optical and infrared technology. The facility was designed and built for the calibration and testing of the new generation large aperture long wave infrared (LWIR) sensors, seekers, and related technologies. Capability exists to perform both radiometric and goniometric calibrations of large infrared sensors under simulated environmental operating conditions. The system is presently configured for endoatmospheric calibrations with a uniform background field which can be set to simulate the expected mission background levels. During calibration, the sensor under test is also exposed to expected mission temperatures and pressures within the test chamber. Capability exists to convert the facility for exoatmospheric testing. The configuration of the system is described along with hardware elements and changes made to date are addressed.

  13. Detection of COL III in Parchment by Amino Acid Analysis

    DEFF Research Database (Denmark)

    Vestergaard Poulsen Sommer, Dorte; Larsen, René

    2016-01-01

    Cultural heritage parchments made from the reticular dermis of animals have been subject to studies of deterioration and conservation by amino acid analysis. The reticular dermis contains a varying mixture of collagen I and III (COL I and III). When dealing with the results of the amino acid...... analyses, till now the COL III content has not been taken into account. Based on the available amino acid sequences we present a method for determining the amount of COL III in the reticular dermis of new and historical parchments calculated from the ratio of Ile/Val. We find COL III contents between 7...... and 32 % in new parchments and between 0.2 and 40 % in the historical parchments. This is consistent with results in the literature. The varying content of COL III has a significant influence on the uncertainty of the amino acid analysis. Although we have not found a simple correlation between the COL...

  14. An environmentally safe and effective paint removal process for aircraft

    Science.gov (United States)

    Kozol, Joseph

    2001-03-01

    To reduce hazardous waste from fleet and depot aircraft paint stripping and to conform to regulations banning toxic chemical paint strippers, the U.S. Naval Air Systems Team (materials division, depots, and head-quarters) teamed with the U.S. Air Force at Warner Robins Air Logistics Center for concept development, characterization, and demonstration of a mature, advanced paint-removal system, the Boeing xenon/flashlamp CO2 (Flashjet®) process. Extensive metallic and composite-materials testing was conducted. This paper describes the development and characterization program leading to authorization of the process for use on fixed-wing navy aircraft.

  15. col, pepino, lechuga, zanahoria y remolacha

    Directory of Open Access Journals (Sweden)

    Roberto Valdés Roque

    2006-01-01

    Full Text Available El objetivo del presente trabajo fue conformar los complejos tecnológicos para cultivos varios (hortalizas menores: cebolla, ajo, col, pepino, lechuga, zanahoria y remolacha. Para la conformación de los mismos se realizó una revisión bibliográfica relacionada con las temáticas de mecanización, donde se obtuvieron los criterios y orientaciones fundamentales para la selección de los equipos componentes de los complejos tecnológicos, así como las características técnicas que deben tener con el propósito de cumplir las exigencias agrotécnicas de los cultivos. Estos objetivos fueron cumplidos como puede apreciarse en los resultados y las conclusiones.

  16. Advanced turboprop testbed systems study. Volume 1: Testbed program objectives and priorities, drive system and aircraft design studies, evaluation and recommendations and wind tunnel test plans

    Science.gov (United States)

    Bradley, E. S.; Little, B. H.; Warnock, W.; Jenness, C. M.; Wilson, J. M.; Powell, C. W.; Shoaf, L.

    1982-01-01

    The establishment of propfan technology readiness was determined and candidate drive systems for propfan application were identified. Candidate testbed aircraft were investigated for testbed aircraft suitability and four aircraft selected as possible propfan testbed vehicles. An evaluation of the four candidates was performed and the Boeing KC-135A and the Gulfstream American Gulfstream II recommended as the most suitable aircraft for test application. Conceptual designs of the two recommended aircraft were performed and cost and schedule data for the entire testbed program were generated. The program total cost was estimated and a wind tunnel program cost and schedule is generated in support of the testbed program.

  17. Trust Control of VTOL Aircraft Part Deux

    Science.gov (United States)

    Dugan, Daniel C.

    2014-01-01

    Thrust control of Vertical Takeoff and Landing (VTOL) aircraft has always been a debatable issue. In most cases, it comes down to the fundamental question of throttle versus collective. Some aircraft used throttle(s), with a fore and aft longitudinal motion, some had collectives, some have used Thrust Levers where the protocol is still "Up is Up and Down is Down," and some have incorporated both throttles and collectives when designers did not want to deal with the Human Factors issues. There have even been combinations of throttles that incorporated an arc that have been met with varying degrees of success. A previous review was made of nineteen designs without attempting to judge the merits of the controller. Included in this paper are twelve designs entered in competition for the 1961 Tri-Service VTOL transport. Entries were from a Bell/Lockheed tiltduct, a North American tiltwing, a Vanguard liftfan, and even a Sikorsky tiltwing. Additional designs were submitted from Boeing Wichita (direct lift), Ling-Temco-Vought with its XC-142 tiltwing, Boeing Vertol's tiltwing, Mcdonnell's compound and tiltwing, and the Douglas turboduct and turboprop designs. A private party submitted a re-design of the Breguet 941 as a VTOL transport. It is important to document these 53 year-old designs to preserve a part of this country's aviation heritage.

  18. Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis

    Science.gov (United States)

    Malone, Andrew F; Phelan, Paul J; Hall, Gentzon; Cetincelik, Umran; Homstad, Alison; Alonso, Andrea; Jiang, Ruiji; Lindsey, Thomas; Wu, Guanghong; Sparks, Matthew A; Smith, Stephen R; Webb, Nicholas J A; Kalra, Philip; Adeyemo, Adebowale; Shaw, Andrey S; Conlon, Peter J; Jennette, J Charles; Howell, David N; Winn, Michelle P; Gbadegesin, Rasheed A

    2014-01-01

    Focal segmental glomerulosclerosis (FSGS) is a histological lesion with many causes including inherited genetic defects with significant proteinuria being the predominant clinical finding at presentation. Mutations in COL4A3 and COL4A4 are known to cause Alport syndrome, thin basement membrane nephropathy, and to result in pathognomonic glomerular basement membrane findings. Secondary FSGS is known to develop in classic Alport Syndrome at later stages of the disease. Here, we present seven families with rare or novel variants in COL4A3 or COL4A4 (six with single and one with two heterozygous variants) from a cohort of 70 families with a diagnosis of hereditary FSGS. The predominant clinical findings at diagnosis were proteinuria associated with hematuria. In all seven families, there were individuals with nephrotic range proteinuria with histologic features of FSGS by light microscopy. In one family, electron microscopy showed thin glomerular basement membrane, but four other families had variable findings inconsistent with classical Alport nephritis. There was no recurrence of disease after kidney transplantation. Families with COL4A3 and COL4A4 variants that segregated with disease represent 10% of our cohort. Thus, COL4A3 and COL4A4 variants should be considered in the interpretation of next-generation sequencing data from such patients. Furthermore, this study illustrates the power of molecular genetic diagnostics in the clarification of renal phenotypes. PMID:25229338

  19. CID Aircraft slap-down

    Science.gov (United States)

    1984-01-01

    In this photograph the B-720 is seen during the moments of initial impact. The left wing is digging into the lakebed while the aircraft continues sliding towards wing openers. In 1984 NASA Dryden Flight Research Facility and the Federal Aviation Administration (FAA) teamed-up in a unique flight experiment called the Controlled Impact Demonstration (CID). The test involved crashing a Boeing 720 aircraft with four JT3C-7 engines burning a mixture of standard fuel with an additive, Anti-misting Kerosene (AMK), designed to supress fire. In a typical aircraft crash, fuel spilled from ruptured fuel tanks forms a fine mist that can be ignited by a number of sources at the crash site. In 1984 the NASA Dryden Flight Research Facility (after 1994 a full-fledged Center again) and the Federal Aviation Administration (FAA) teamed-up in a unique flight experiment called the Controlled Impact Demonstration (CID), to test crash a Boeing 720 aircraft using standard fuel with an additive designed to supress fire. The additive, FM-9, a high-molecular-weight long-chain polymer, when blended with Jet-A fuel had demonstrated the capability to inhibit ignition and flame propagation of the released fuel in simulated crash tests. This anti-misting kerosene (AMK) cannot be introduced directly into a gas turbine engine due to several possible problems such as clogging of filters. The AMK must be restored to almost Jet-A before being introduced into the engine for burning. This restoration is called 'degradation' and was accomplished on the B-720 using a device called a 'degrader.' Each of the four Pratt & Whitney JT3C-7 engines had a 'degrader' built and installed by General Electric (GE) to break down and return the AMK to near Jet-A quality. In addition to the AMK research the NASA Langley Research Center was involved in a structural loads measurement experiment, which included having instrumented dummies filling the seats in the passenger compartment. Before the final flight on December 1

  20. The experimental determination of atmospheric absorption from aircraft acoustic flight tests

    Science.gov (United States)

    Miller, R. L.; Oncley, P. B.

    1971-01-01

    A method for determining atmospheric absorption coefficients from acoustic flight test data is presented. Measurements from five series of acoustic flight tests were included in the study. The number of individual flights totaled 24: six Boeing 707 flights performed in May 1969 in connection with the turbofan nacelle modification program, eight flights from Boeing tests conducted during the same period, and 10 flights of the Boeing 747 airplane. The effects of errors in acoustic, meteorological, and aircraft performance and position measurements are discussed. Tabular data of the estimated sample variance of the data for each test are given for source directivity angles from 75 deg to 120 deg and each 1/3-octave frequency band. Graphic comparisons are made of absorption coefficients derived from ARP 866, using atmospheric profile data, with absorption coefficients determined by the experimental method described in the report.

  1. Experimental and Computational Sonic Boom Assessment of Boeing N+2 Low Boom Models

    Science.gov (United States)

    Durston, Donald A.; Elmiligui, Alaa; Cliff, Susan E.; Winski, Courtney S.; Carter, Melissa B.; Walker, Eric L.

    2015-01-01

    Near-field pressure signatures were measured and computational predictions made for several sonic boom models representing Boeing's Quiet Experimental Validation Concept (QEVC) supersonic transport, as well as three axisymmetric calibration models. Boeing developed the QEVC under a NASA Research Announcement (NRA) contract for Experimental Systems Validations for N+2 Supersonic Commercial Transport Aircraft, which was led by the NASA High Speed Project under the Fundamental Aeronautics Program. The concept was designed to address environmental and performance goals given in the NRA, specifically for low sonic boom loudness levels and high cruise efficiency, for an aircraft anticipated to enter service in the 2020 timeframe. Wind tunnel tests were conducted on the aircraft and calibration models during Phases I and II of the NRA contract from 2011 to 2013 in the NASA Ames 9- by 7-Foot and NASA Glenn 8- by 6-Foot Supersonic Wind Tunnels. Sonic boom pressure signatures were acquired primarily at Mach 1.6 and 1.8, and force and moment data were acquired from Mach 0.8 to 1.8. The sonic boom test data were obtained using a 2-in. flat-top pressure rail and a 14-in. round-top tapered "reflection factor 1" (RF1) pressure rail. Both rails capture an entire pressure signature in one data point, and successive signatures at varying positions along or above the rail were used to improve data quality through spatial averaging. The sonic boom data obtained by the rails were validated with high-fidelity numerical simulations of off-body pressures using the CFD codes USM3D, Cart3D, and OVERFLOW. The test results from the RF1 rail showed good agreement between the computational and experimental data when a variety of testing techniques including spatial averaging of a series of pressure signatures were employed, however, reflections off the 2-in. flat-top rail caused distortions in the signatures that did not agree with the CFD predictions. The 9 x 7 and 8 x 6 wind tunnels generally

  2. Aircraft Design

    Science.gov (United States)

    Bowers, Albion H. (Inventor); Uden, Edward (Inventor)

    2016-01-01

    The present invention is an aircraft wing design that creates a bell shaped span load, which results in a negative induced drag (induced thrust) on the outer portion of the wing; such a design obviates the need for rudder control of an aircraft.

  3. B-52 Launch Aircraft in Flight

    Science.gov (United States)

    2001-01-01

    the development of parachute recovery systems used to recover the space shuttle solid rocket booster casings. It also supported eight orbiter (space shuttle) drag chute tests in 1990. In addition, the B-52 served as the air launch platform for the first six Pegasus space boosters. During its many years of service, the B-52 has undergone several modifications. The first major modification was made by North American Aviation (now part of Boeing) in support of the X-15 program. This involved creating a launch-panel-operator station for monitoring the status of the test vehicle being carried, cutting a large notch in the right inboard wing flap to accommodate the vertical tail of the X-15 aircraft, and installing a wing pylon that enables the B-52 to carry research vehicles and test articles to be air-launched/dropped. Located on the right wing, between the inboard engine pylon and the fuselage, this wing pylon was subjected to extensive testing prior to its use. For each test vehicle the B-52 carried, minor changes were made to the launch-panel operator's station. Built originally by the Boeing Company, the NASA B-52 is powered by eight Pratt & Whitney J57-19 turbojet engines, each of which produce 12,000 pounds of thrust. The aircraft's normal launch speed has been Mach 0.8 (about 530 miles per hour) and its normal drop altitude has been 40,000 to 45,000 feet. It is 156 feet long and has a wing span of 185 feet.

  4. Resistance ability evaluation of safety-related structures for the simulated aircraft accident

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Jin; Kim, Sung Woon; Choi, Jang Kyu [Daewoo E and C Co., Ltd., Suwon (Korea, Republic of)] (and others)

    2003-03-15

    Aircraft accidents on nuclear safety-related structures can cause severe damage to the safety of NPP(Nuclear Power Plant)s. To assess the safety of nuclear safety-related structures, the local damage and the dynamic response of global structures should be investigated together. This study have compared several local damage assessment formulas suggested for aircraft as an impactor, and have set the assessment system of local damage for impact-proof design of NPP containment buildings. And the local damage of nuclear safety-related structures in operation in Korea for commercial aircraft as impactor have been estimated. Impact load-time functions of the aircraft crash have been decided to assessment the safety of nuclear safety-related structures against the intentional colliding of commercial aircraft. Boeing 747 and Boeing 767 is selected as target aircraft based on the operation frequencies and weights. Comparison of the fire analysis methods showed that the method considering heat convection and radiation is adequate for the temperature analysis of the aircraft fuel fire. Finally, the study covered the analysis of the major structural drawings and design drawings with which three-dimensional finite element model analysis is expected to be performed.

  5. SearchCol: Metaheuristic Search by Column Generation

    Science.gov (United States)

    Alvelos, Filipe; de Sousa, Amaro; Santos, Dorabella

    We propose a general framework for the combination of column generation (CG) with metaheuristics (MHs) aiming to solve combinatorial optimization problems amenable for decomposition approaches, "SearchCol". The combination of the two approaches is based on representing the solution of the problem as the selection of a subset of solutions of smaller (sub)problems which are generated by CG. In each iteration of a SearchCol algorithm, CG provides the optimal solution (primal and dual) to the MH which returns a (incumbent) solution used for defining the (perturbed) CG problem of the next iteration. We describe the SearchCol framework and a general SearchCol algorithm based on local search.

  6. Structural changes in mixed Col I/Col V collagen gels probed by SHG microscopy: implications for probing stromal alterations in human breast cancer.

    Science.gov (United States)

    Ajeti, Visar; Nadiarnykh, Oleg; Ponik, Suzanne M; Keely, Patricia J; Eliceiri, Kevin W; Campagnola, Paul J

    2011-08-01

    Second Harmonic Generation (SHG) microscopy has been previously used to describe the morphology of collagen in the extracellular matrix (ECM) in different stages of invasion in breast cancer. Here this concept is extended by using SHG to provide quantitative discrimination of self-assembled collagen gels, consisting of mixtures of type I (Col I) and type V (Col V) isoforms which serve as models of changes in the ECM during invasion in vivo. To investigate if SHG is sensitive to changes due to Col V incorporation into Col I fibrils, gels were prepared with 0-20% Col V with the balance consisting of Col I. Using the metrics of SHG intensity, fiber length, emission directionality, and depth-dependent intensities, we found similar responses for gels comprised of 100% Col I, and 95% Col I/5% Col V, where these metrics were all significantly different from those of the 80% Col I/20% Col V gels. Specifically, the gels of lower Col V content produce brighter SHG, are characterized by longer fibers, and have a higher forward/backward emission ratio. These attributes are all consistent with more highly organized collagen fibrils/fibers and are in agreement with previous TEM characterization as well as predictions based on phase matching considerations. These results suggest that SHG can be developed to discriminate Col I/Col V composition in tissues to characterize and follow breast cancer invasion.

  7. 76 FR 81879 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2011-12-29

    ... available in the AD docket shortly after receipt. FOR FURTHER INFORMATION CONTACT: Ivan Li, Aerospace...., Renton, Washington 98057-3356; phone: (425) 917-6437; fax: (425) 917-6590; email: ivan.li@faa.gov... clips, and contacting Boeing for repair instructions and doing the repair for main upper sill web...

  8. 77 FR 73282 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-12-10

    ... compliance time, as proposed in the NPRM (77 FR 11789, February 28, 2012). Korean Air Lines (KAL), Air... Language Boeing requested we revise the sentence in the Summary section of the NPRM (77 FR 11789, February... language that describes the precipitating event. Regardless of whether the flight crew adhered...

  9. 77 FR 12166 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-02-29

    ... number six auxiliary slat track, causing electrical wires in the bundle to arc, which damaged both the..., contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707, MC 2H-65... wires in the bundle to arc, which damaged both the auxiliary slat track and power feeder wires....

  10. 78 FR 72791 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-12-04

    ... result in arc-through of the conduit, and consequent fire or explosion of the fuel tank. DATES: This AD..., contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707, MC 2H-65... result in arc-through of the conduit, and consequent fire or explosion of the fuel tank. (f)...

  11. Boeing to Rank Colleges by Measuring Graduates' Job Success

    Science.gov (United States)

    Basken, Paul

    2008-01-01

    Boeing Company, the Chicago-based aerospace giant, has spent the past year matching internal data from employee evaluations with information about the colleges its engineers attended. It has used that analysis to create a ranking system, which it plans to unveil in the coming month, that will show which colleges have produced the workers it…

  12. 77 FR 46932 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-08-07

    .... Request To Address Effects of NPRM (76 FR 78574, December 19, 2011) on Winglets Aviation Partners Boeing... Service Bulletin 767-57A0126, dated August 12, 2011, and has determined that the installation of winglets... the installation of these winglets does not affect accomplishing the NPRM. American Airlines...

  13. 78 FR 21236 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-04-10

    ..., August 16, 2012) on Winglets Aviation Partners Boeing (APB) stated that it has reviewed the NPRM (77 FR... that the installation of winglets, per Supplemental Type Certificate (STC) ST01518SE, ``does not affect them.'' We infer that APB means the installation of these winglets does not affect accomplishing...

  14. 78 FR 28729 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-05-16

    ... Regarding the Installation of Winglets Aviation Partners Boeing (APB) stated that it has reviewed the NPRM... installation of winglets per Supplemental Type Certificate (STC) ST01518SE (http://rgl.faa.gov/Regulatory--and... commenter's statement that the installation of winglets as specified in STC ST01518SE...

  15. 78 FR 61164 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-10-03

    ... bushings, and inner cylinder bushings. For all airplanes, this AD requires a maintenance program revision... proposed to require a maintenance program revision, one-time inspections of the MLG truck beam, and related..., 2013) to specify the repetitive interval for the lubrication schedule (as referenced in Boeing...

  16. 77 FR 36139 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-06-18

    ... significant economic impact, positive or negative, on a substantial number of small entities under the... current inspections for cracking of the frame, HFEC inspections for cracking of the reinforcement angle..., and reinforcement angle, in accordance with the Accomplishment Instructions of Boeing Alert...

  17. 78 FR 22439 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-04-16

    ... Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed... all The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500 series airplanes. The existing... around the galley service doorway hinge cutouts, add inspections of certain repaired structure at...

  18. 77 FR 61542 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-10-10

    ... flange of the inboard track at the rear spar attachment of each outboard flap, and eventual rework of the... the rear spar attachment of each outboard flap, and eventual rework of the flap track assembly and..., repair or rework the flap track per the ``Repair and Rework Instructions'' specified in Boeing AOM...

  19. Gezondheidsrisico's brand EL AL-Boeing

    NARCIS (Netherlands)

    van Bruggen M; Janssen PJCM; Kliest JJG; Meulenbelt J; Smetsers RCGM; Uijt de Haag PAM; de Mik G; Elzinga G; IEM; CSR; VIC; LSO; SB4; DIR

    1998-01-01

    Op verzoek van het ministerie van VWS heeft het RIVM onderzoek verricht naar mogelijke gezondheidsrisico's van de verbranding of verspreiding van stoffen en goederen die zich aan boord bevonden van de in 1992 verongelukte El Al-Boeing. Allereerst heeft het RIVM de in de ladinglijst genoemde st

  20. 78 FR 42895 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-07-18

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM... to detect WFD before it becomes a hazard to flight. We will not grant any extensions of...

  1. Boeing vallandas ebaeetilise finantsjuhi / Annika Matson, Raivo Sormunen

    Index Scriptorium Estoniae

    Matson, Annika, 1976-

    2003-01-01

    USA lennukitootja Boeing finantsjuht Mike Sears vallandati USA Õhujõududes hankespetsialistina töötanud Darleen Druyuni palkamise ning sel viisil Boeingut puudutavate lepingute mõjutamise tõttu. Diagramm: Boeingu käive kannatab skandaali tõttu

  2. The Boeing Company's Manufacturing Technology Student Internship. Evaluation Report.

    Science.gov (United States)

    Owens, Thomas R.

    The Boeing Company contracted with the Northwest Regional Educational Laboratory to evaluate its student internship program, part of a "school-to-work" effort modeled after the nationally recognized Tech Prep initiative. The company's involvement in the Tech Prep Program has been implemented in three phases: (1) the initial phase helped…

  3. Boeing Company gives again to engineering design team endowment

    OpenAIRE

    Owczarski, Mark

    2008-01-01

    In 2007 Virginia Tech's Student Engineers' Council announced the creation of an endowment to benefit student design teams at the university. During the fall semester of 2007, The Boeing Company increased the size of this endowment with a gift of $50,000 from its Global Corporate Citizenship disaster relief team budget and a second gift of $15,000 from its grants program.

  4. Amphibious Aircraft

    Data.gov (United States)

    National Aeronautics and Space Administration — A brief self composed research article on Amphibious Aircrafts discussing their use, origin and modern day applications along with their advantages and disadvantages...

  5. Detection of COL III in parchment by amino acid analysis.

    Science.gov (United States)

    Sommer, Dorte V P; Larsen, René

    2016-01-01

    Cultural heritage parchments made from the reticular dermis of animals have been subject to studies of deterioration and conservation by amino acid analysis. The reticular dermis contains a varying mixture of collagen I and III (COL I and III). When dealing with the results of the amino acid analyses, till now the COL III content has not been taken into account. Based on the available amino acid sequences, we present a method for determining the amount of COL III in the reticular dermis of new and historical parchments calculated from the ratio of Ile/Val. We find COL III contents between 7 and 32 % in new parchments and between 0.2 and 40 % in the historical parchments. This is consistent with results in the literature. The varying content of COL III has a significant influence on the uncertainty of the amino acid analysis. Although we have not found a simple correlation between the COL III content and the degree of deterioration, our results show that this question must be taken into consideration in future studies of the chemical and physical deterioration of parchment measured by amino acid analysis and other analytical methods.

  6. Flight dynamics and control modelling of damaged asymmetric aircraft

    Science.gov (United States)

    Ogunwa, T. T.; Abdullah, E. J.

    2016-10-01

    This research investigates the use of a Linear Quadratic Regulator (LQR) controller to assist commercial Boeing 747-200 aircraft regains its stability in the event of damage. Damages cause an aircraft to become asymmetric and in the case of damage to a fraction (33%) of its left wing or complete loss of its vertical stabilizer, the loss of stability may lead to a fatal crash. In this study, aircraft models for the two damage scenarios previously mentioned are constructed using stability derivatives. LQR controller is used as a direct adaptive control design technique for the observable and controllable system. Dynamic stability analysis is conducted in the time domain for all systems in this study.

  7. Finite-difference modeling of commercial aircraft using TSAR

    Energy Technology Data Exchange (ETDEWEB)

    Pennock, S.T.; Poggio, A.J.

    1994-11-15

    Future aircraft may have systems controlled by fiber optic cables, to reduce susceptibility to electromagnetic interference. However, the digital systems associated with the fiber optic network could still experience upset due to powerful radio stations, radars, and other electromagnetic sources, with potentially serious consequences. We are modeling the electromagnetic behavior of commercial transport aircraft in support of the NASA Fly-by-Light/Power-by-Wire program, using the TSAR finite-difference time-domain code initially developed for the military. By comparing results obtained from TSAR with data taken on a Boeing 757 at the Air Force Phillips Lab., we hope to show that FDTD codes can serve as an important tool in the design and certification of U.S. commercial aircraft, helping American companies to produce safe, reliable air transportation.

  8. Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis

    OpenAIRE

    Malone, Andrew F.; Phelan, Paul J.; Hall, Gentzon; Cetincelik, Umran; Homstad, Alison; Alonso, Andrea; Jiang, Ruiji; Lindsey, Thomas; Wu, Guanghong; Sparks, Matthew A.; Smith, Stephen R.; Webb, Nicholas J. A.; Kalra, Philip; Adeyemo, Adebowale; Shaw, Andrey S.

    2014-01-01

    Focal segmental glomerulosclerosis (FSGS) is a histological lesion with many causes including inherited genetic defects with significant proteinuria being the predominant clinical finding at presentation. Mutations in COL4A3 and COL4A4 are known to cause Alport syndrome, thin basement membrane nephropathy, and to result in pathognomonic glomerular basement membrane findings. Secondary FSGS is known to develop in classic Alport Syndrome at later stages of the disease. Here, we present seven fa...

  9. Structural analysis at aircraft conceptual design stage

    Science.gov (United States)

    Mansouri, Reza

    In the past 50 years, computers have helped by augmenting human efforts with tremendous pace. The aircraft industry is not an exception. Aircraft industry is more than ever dependent on computing because of a high level of complexity and the increasing need for excellence to survive a highly competitive marketplace. Designers choose computers to perform almost every analysis task. But while doing so, existing effective, accurate and easy to use classical analytical methods are often forgotten, which can be very useful especially in the early phases of the aircraft design where concept generation and evaluation demands physical visibility of design parameters to make decisions [39, 2004]. Structural analysis methods have been used by human beings since the very early civilization. Centuries before computers were invented; the pyramids were designed and constructed by Egyptians around 2000 B.C, the Parthenon was built by the Greeks, around 240 B.C, Dujiangyan was built by the Chinese. Persepolis, Hagia Sophia, Taj Mahal, Eiffel tower are only few more examples of historical buildings, bridges and monuments that were constructed before we had any advancement made in computer aided engineering. Aircraft industry is no exception either. In the first half of the 20th century, engineers used classical method and designed civil transport aircraft such as Ford Tri Motor (1926), Lockheed Vega (1927), Lockheed 9 Orion (1931), Douglas DC-3 (1935), Douglas DC-4/C-54 Skymaster (1938), Boeing 307 (1938) and Boeing 314 Clipper (1939) and managed to become airborne without difficulty. Evidencing, while advanced numerical methods such as the finite element analysis is one of the most effective structural analysis methods; classical structural analysis methods can also be as useful especially during the early phase of a fixed wing aircraft design where major decisions are made and concept generation and evaluation demands physical visibility of design parameters to make decisions

  10. Active Flow Control (AFC) and Insect Accretion and Mitigation (IAM) System Design and Integration on the Boeing 757 ecoDemonstrator

    Science.gov (United States)

    Alexander, Michael G.; Harris, F. Keith; Spoor, Marc A.; Boyland, Susannah R.; Farrell, Thomas E.; Raines, David M.

    2016-01-01

    This paper presents a systems overview of how the Boeing and NASA team designed, analyzed, fabricated, and integrated the Active Flow Control (AFC) technology and Insect Accretion Mitigation (IAM) systems on the Boeing 757 ecoDemonstrator. The NASA Environmentally Responsible Aviation (ERA) project partnered with Boeing to demonstrate these two technology systems on a specially outfitted Boeing 757 ecoDemonstrator during the spring of 2015. The AFC system demonstrated attenuation of flow separation on a highly deflected rudder and increased the side force generated. This AFC system may enable a smaller vertical tail to provide the control authority needed in the event of an engine failure during takeoff while still operating in a conventional manner over the rest of the flight envelope. The AFC system consisted of ducting to obtain air from the Auxiliary Power Unit (APU), a control valve to modulate the system mass flow, a heat exchanger to lower the APU air temperature, and additional ducting to deliver the air to the AFC actuators located on the vertical tail. The IAM system demonstrated how to mitigate insect residue adhesion on a wing's leading edge. Something as small as insect residue on a leading edge can cause turbulent wedges that interrupt laminar flow, resulting in an increase in drag and fuel use. The IAM system consisted of NASA developed Engineered Surfaces (ES) which were thin aluminum sheet substrate panels with coatings applied to the exterior. These ES were installed on slats 8 and 9 on the right wing of the 757 ecoDemonstrator. They were designed to support panel removal and installation in one crew shift. Each slat accommodated 4 panels. Both the AFC and IAM flight test were the culmination of several years of development and produced valuable data for the advancement of modern aircraft designs.

  11. The NASA/Industry Design Analysis Methods for Vibrations (DAMVIBS) Program - Boeing helicopters airframe finite element modeling

    Science.gov (United States)

    Gabel, R.; Lang, P.; Reed, D.

    1992-01-01

    Finite-element modeling of the airframe vibration of the Army/Boeing CH-47D helicopter is conducted with comparisons to experimental data in an effort to improve the design process. A NASTRAN FEM is developed that is fully representative of the test configuration and includes the support fixture, shakers, and the aircraft/shaker suspension system. The analysis is conducted with specific attention given to the prediction of reasonable forced amplitudes throughout the airframe. Reasonable correlation is noted between the FEM and experimental results, although improved correlation can be obtained by including more accurate damping values and secondary effects such as stringer shear loading. It is shown that the general stress model does not provide an adequate dynamic analysis on which to base design improvements. A more detailed model is required that emphasizes highly detailed helicopter elements and employs a finer mesh particularly in the description of the mass distribution.

  12. Air Force KC-X Tanker Aircraft Program: Background and Issues for Congress

    Science.gov (United States)

    2009-12-22

    Air Force is expected late next month.... Sen. Richard Shelby, R- Ala ., a Northrop supporter, and Rep. Norman Dicks, D-Wash., a Boeing supporter...from $2.1 billion per year to $3 billion per year by 2040 due to increasing depot maintenance and forecasted modernization programs in avionics and...China avionics access doors Source: Teal Group Note: Commercial variants of both aircraft types are powered by engines manufactured by either

  13. Conceptual Design and Structural Optimization of NASA Environmentally Responsible Aviation (ERA) Hybrid Wing Body Aircraft

    Science.gov (United States)

    Quinlan, Jesse R.; Gern, Frank H.

    2016-01-01

    Simultaneously achieving the fuel consumption and noise reduction goals set forth by NASA's Environmentally Responsible Aviation (ERA) project requires innovative and unconventional aircraft concepts. In response, advanced hybrid wing body (HWB) aircraft concepts have been proposed and analyzed as a means of meeting these objectives. For the current study, several HWB concepts were analyzed using the Hybrid wing body Conceptual Design and structural optimization (HCDstruct) analysis code. HCDstruct is a medium-fidelity finite element based conceptual design and structural optimization tool developed to fill the critical analysis gap existing between lower order structural sizing approaches and detailed, often finite element based sizing methods for HWB aircraft concepts. Whereas prior versions of the tool used a half-model approach in building the representative finite element model, a full wing-tip-to-wing-tip modeling capability was recently added to HCDstruct, which alleviated the symmetry constraints at the model centerline in place of a free-flying model and allowed for more realistic center body, aft body, and wing loading and trim response. The latest version of HCDstruct was applied to two ERA reference cases, including the Boeing Open Rotor Engine Integration On an HWB (OREIO) concept and the Boeing ERA-0009H1 concept, and results agreed favorably with detailed Boeing design data and related Flight Optimization System (FLOPS) analyses. Following these benchmark cases, HCDstruct was used to size NASA's ERA HWB concepts and to perform a related scaling study.

  14. The Glass Ceiling for Remotely Piloted Aircraft

    Science.gov (United States)

    2013-08-01

    Views July–August 2013 Air & Space Power Journal | 101 The Glass Ceiling for Remotely Piloted Aircraft Lt Col Lawrence Spinetta, PhD, USAF Those...number. 1. REPORT DATE AUG 2013 2. REPORT TYPE 3. DATES COVERED 00-00-2013 to 00-00-2013 4. TITLE AND SUBTITLE The Glass Ceiling for Remotely...promotion to flag rank. By design or effect, a bottleneck exists that guarantees a glass ceiling (i.e., a barrier to advancement) for RPA officers. This

  15. Aircraft cybernetics

    Science.gov (United States)

    1977-01-01

    The use of computers for aircraft control, flight simulation, and inertial navigation is explored. The man-machine relation problem in aviation is addressed. Simple and self-adapting autopilots are described and the assets and liabilities of digital navigation techniques are assessed.

  16. Mapeig col·laboratiu de conflictes socioambientals

    OpenAIRE

    Pérez López, Alfons

    2011-01-01

    L’objectiu general del MCA és desenvolupar una eina que permeti, per una banda, representar i publicar informació en base cartogràfica de conflictes socioambientals per fer-los visibles i despertar la consciència pública, enfortint i apoderant els afectats i afectades, organitzacions socials que els/les hi donen suport; i d’altra banda, que permeti treballar conjuntament i de manera col·laborativa, la informació dels conflictes socioambientals. Els objectius específics del mapatge col·l...

  17. Damage assessment of nuclear containment against aircraft crash

    Energy Technology Data Exchange (ETDEWEB)

    Iqbal, Mohd Ashraf, E-mail: iqbal_ashraf@rediffmail.com; Sadique, Md. Rehan, E-mail: rehan.sadique@gmail.com; Bhargava, Pradeep, E-mail: bhpdpfce@iitr.ac.in; Bhandari, N.M., E-mail: nmbcefce@iitr.ac.in

    2014-10-15

    Highlights: • Damage assessment of nuclear containment is studied against aircraft crash. • Four impact locations have been identified at the outer containment shell. • The mid of the total height has been found to be most vulnerable location. • The crown of dome has been found to be the strongest location. • Phantom F4 caused more localized and severe damage compared to other aircrafts. - Abstract: The behavior of nuclear containment structure has been studied against aircraft crash with an emphasis on the influence of strike location. The impact locations identified on the BWR Mark III type nuclear containment structure are mid-height, junction of dome and cylinder, crown of dome and arc of dome. The containment at each of the above locations has been impacted normally by Phantom F-4, Boeing 707-320 and Airbus A320 aircrafts. The loading of the aircraft has been assigned through the corresponding reaction-time response curve. ABAQUS/Explicit finite element code has been used to carry out the three-dimensional numerical simulations. The concrete damaged plasticity model was used to simulate the behavior of concrete while the behavior of steel reinforcement was incorporated using the Johnson–Cook elasto-viscoplastic material model. The mid-height of containment has been found to experience most severe deformation against each aircraft. Phantom F4 has been found to be most disastrous at each location. The results have been compared with those of the available studies with respect to the containment deformation.

  18. Development of pressure containment and damage tolerance technology for composite fuselage structures in large transport aircraft

    Science.gov (United States)

    Smith, P. J.; Thomson, L. W.; Wilson, R. D.

    1986-01-01

    NASA sponsored composites research and development programs were set in place to develop the critical engineering technologies in large transport aircraft structures. This NASA-Boeing program focused on the critical issues of damage tolerance and pressure containment generic to the fuselage structure of large pressurized aircraft. Skin-stringer and honeycomb sandwich composite fuselage shell designs were evaluated to resolve these issues. Analyses were developed to model the structural response of the fuselage shell designs, and a development test program evaluated the selected design configurations to appropriate load conditions.

  19. 75 FR 52242 - Airworthiness Directives; The Boeing Company Model 737-600, -700, -700C, -800, -900, and -900ER...

    Science.gov (United States)

    2010-08-25

    ...: Manager, Airline Support, e- mail: rse.boecom@boeing.com . The report must include the inspection results..., Airline Support, e-mail: rse.boecom@boeing.com . The report must include the inspection results...

  20. The global decentralization of commercial aircraft production: Implications for United States-based manufacturing activity

    Science.gov (United States)

    Pritchard, David John

    This research explores the role of industrial offset agreements and international subcontracting patterns in the global decentralization of US commercial aircraft production. Particular attention is given to the manufacturing processes involved in the design and assembly of large passenger jets (100 seats or more). It is argued that the current geography of aircraft production at the global level has been shaped by a new international distribution of input costs and technological capability. Specifically, low-cost producers within several of the newly emerging markets (NEMs) have acquired front-end manufacturing expertise as a direct result of industrial offset contracts and/or other forms of technology transfer (e.g. international joint-ventures, imports of advanced machine tools). The economic and technological implications of industrial offset (compensatory trade) are examined with reference to the commercial future of US aircraft production. Evidence gathered via personal interviews with both US and foreign producers suggests that the current Western duopoly (Boeing and Airbus) faces a rather uncertain future. In particular, the dissertation shows that the growth of subcontracting and industrial offset portends the transformation of Boeing from an aircraft manufacturer to a systems integrator. The economic implications of this potential reconfiguration of the US aircraft industry are discussed in the context of several techno-market futures, some of which look rather bleak for US workers in this industry.

  1. Complete COL1A1 allele deletions in osteogenesis imperfecta

    NARCIS (Netherlands)

    van Dijk, Fleur S.; Huizer, Margriet; Kariminejad, Ariana; Marcelis, Carlo L.; Plomp, Astrid S.; Terhal, Paulien A.; Meijers-Heijboer, Hanne; Weiss, Marjan M.; van Rijn, Rick R.; Cobben, Jan M.; Pals, Gerard

    2010-01-01

    Purpose: To identify a molecular genetic cause in patients with a clinical diagnosis of osteogenesis imperfecta (OI) type I/IV. Methods: The authors performed multiplex ligation-dependent probe amplification analysis of the COL1A1 gene in a group of 106 index patients. Results: In four families with

  2. EuroCirCol: A key to New Physics

    CERN Multimedia

    Johannes Gutleber

    2015-01-01

    Monday 1 June saw the start of EuroCirCol, the EC-funded part of the FCC study that will develop the conceptual design for an energy-frontier hadron collider.   Attendees at the EuroCirCol meeting at CERN. The EuroCirCol kick-off event at CERN on 2 to 4 June brought together 62 participants to constitute governance bodies, commit to the project plan and align the organisation, structures and processes of 16 institutions from 10 countries. The goal of the project is to conceive a post-LHC research infrastructure around a 100 km circular energy-frontier hadron collider capable of reaching 100 TeV collisions. The project officially started on 1 June and will run for four years. The total estimated budget of 11.2 MEUR includes a 2.99 MEUR contribution from the Horizon 2020 programme dedicated to the development of new world-class research infrastructures. EuroCirCol will deliver a design for a hadron collider as part of the broader Future Circular Collider (FCC) study. It will provide input to an...

  3. 75 FR 15328 - Airworthiness Directives; The Boeing Company Model 757 Airplanes

    Science.gov (United States)

    2010-03-29

    ...: Nicholas Wilson, Aerospace Engineer, Cabin Safety and Environmental Systems Branch, ANM-150S, FAA, Seattle... Boeing Service Bulletin 757-35A0015, Revision 2, dated June 15, 2000. The commenter states that this... condition. The commenter also states that, since Boeing Service Bulletin 757-35A0015, dated September...

  4. RFID Transponders' Radio Frequency Emissions in Aircraft Communication and Navigation Radio Bands

    Science.gov (United States)

    Nguyen, Truong X.; Ely, Jay J.; Williams, Reuben A.; Koppen, Sandra V.; Salud, Maria Theresa P.

    2006-01-01

    Radiated emissions in aircraft communication and navigation bands are measured from several active radio frequency identification (RFID) tags. The individual tags are different in design and operations. They may also operate in different frequency bands. The process for measuring the emissions is discussed, and includes tag interrogation, reverberation chamber testing, and instrument settings selection. The measurement results are described and compared against aircraft emission limits. In addition, interference path loss for the cargo bays of passenger aircraft is measured. Cargo bay path loss is more appropriate for RFID tags than passenger cabin path loss. The path loss data are reported for several aircraft radio systems on a Boeing 747 and an Airbus A320.

  5. No association between polymorphisms and haplotypes of COL1A1 and COL1A2 genes and osteoporotic fracture in postmenopausal Chinese women

    Institute of Scientific and Technical Information of China (English)

    Wei-wei HU; Miao LI; Yu-juan LIU; Zhen-Iin ZHANG; Jin-wei HE; Hao ZHANG; Chun WANG; Jie-mei GU; Hua YUE; Yao-hua KE; Yun-qiu HU; Wen-zhen FU

    2011-01-01

    Aim: To study whether genetic polymorphisms of COL1A1 and COL1A2 genes affected the onset of fracture in postmenopausal Chinese women.Methods: SNPs in COL1A1 and COL1A2 genes were identified via direct sequencing in 32 unrelated postmenopausal Chinese women.Ten SNPs were genotyped in 1252 postmenopausal Chinese women. The associations were examined using both single-SNP and hapIotype tests using logistic regression.Results: Twenty four (4 novel) and 28 (7 novel) SNPs were identified in COL1A1 and COL1A2 gene, respectively. The distribution frequencies of 2 SNPs in COL1A1 (rs2075554 and rs2586494) and 3 SNPs in COL1A2 (rs42517, rs1801182, and rs42524) were significantly different from those documented for the European Caucasian population. No significant difference was observed between fracture and control groups with respect to allele frequency or genotype distribution in 9 selected SNPs and haplotype. No significant association was found between fragility fracture and each SNP or haplotype. The results remained the same after additional corrections for other risk factors such as weight, height, and bone mineral density.Conclusion: Our results show no association between common genetic variations of COL1A1 and COL1A2 genes and fracture, suggesting the complex genetic background of osteoporotic fractures.

  6. Scaling Trajectories in Civil Aircraft (1913-1997)

    CERN Document Server

    Frenken, Koen

    2010-01-01

    Using entropy statistics we analyse scaling patterns in terms of changes in the ratios among product characteristics of 143 designs in civil aircraft. Two allegedly dominant designs, the piston propeller DC3 and the turbofan Boeing 707, are shown to have triggered a scaling trajectory at the level of the respective firms. Along these trajectories different variables have been scaled at different moments in time: this points to the versatility of a dominant design which allows a firm to react to a variety of user needs. Scaling at the level of the industry took off only after subsequently reengineered models were introduced, like the piston propeller Douglas DC4 and the turbofan Boeing 767. The two scaling trajectories in civil aircraft corresponding to the piston propeller and the turbofan paradigm can be compared with a single, less pronounced scaling trajectory in helicopter technology for which we have data during the period 1940-1996. Management and policy implications can be specified in terms of the pha...

  7. Engine Bird Ingestion Experience of the Boeing 747 Aircraft - Expanded Data Base (October 1986 - September 1989).

    Science.gov (United States)

    1992-07-01

    has occurred, Is approximately one-half of one percent. Engtine Damare Some types of engine damage are correlated with other types of damage. The...0 GUM GUAM, GUAM N FGN 289 0 366 0 145 0 800 0 GVA GENEVA, SWITZERLAND N FGN 10594 0 10520 1 11863 0 32977 1 GWL GWALIOR, INDIZ N FGN 1460 0 1422 1

  8. Study of the Engine Bird Ingestion Experience of the Boeing 737 Aircraft

    Science.gov (United States)

    1989-10-01

    338 AST AL BNA. SAUDI ARABIA N NO 4- 1148 ABV A8UJA. NIGERIA N NO 4- 1248 ASZ ABERDEEd, SCOTLAND N NO -4- 1519 ACA ACAPULCO. MEXICO N NO 6- 126 AC...NO -4- 1966 AGS AUGUSTA. GA. USA N YES GA 1579 A1B ASMA . SAUDI ARABIA N NO -4- 2626 A4U AL HOCEIMA, MOROCCO N NO -4- 292 AJA AJACCIO. CORSICA. FRANCE...Cru CHEIGOU. P.R. CHINA N NO -4- 2138 CUM CANCUM, MEXICO N NO -- 634 CUR CURACAO. NETH ANTILLES N NO -4- 20 cyc CINCINNATI. OH. USA N YES OH 14496 coo

  9. Artificial Icing Test, Utility Tactical Transport Aircraft System (UTTAS), Boeing Vertol YUH-61A Helicopter

    Science.gov (United States)

    1977-01-01

    or approval of the use of the commercial hardware and software . L IL UNCLASSIFIED SECURITY CLASSIFICATION OF: THIS PAGE ("Oen flea. nt REPORT...gravity normal acceleration Copilot/ Enineer Station Instrumentation controls and lights On-board camera controls and lights Data recorder switch Event

  10. Subsonic Ultra Green Aircraft Research. Phase II - Volume I; Truss Braced Wing Design Exploration

    Science.gov (United States)

    Bradley, Marty K.; Droney, Christopher K.; Allen, Timothy J.

    2015-01-01

    This report summarizes the Truss Braced Wing (TBW) work accomplished by the Boeing Subsonic Ultra Green Aircraft Research (SUGAR) team, consisting of Boeing Research and Technology, Boeing Commercial Airplanes, General Electric, Georgia Tech, Virginia Tech, NextGen Aeronautics, and Microcraft. A multi-disciplinary optimization (MDO) environment defined the geometry that was further refined for the updated SUGAR High TBW configuration. Airfoil shapes were tested in the NASA TCT facility, and an aeroelastic model was tested in the NASA TDT facility. Flutter suppression was successfully demonstrated using control laws derived from test system ID data and analysis models. Aeroelastic impacts for the TBW design are manageable and smaller than assumed in Phase I. Flutter analysis of TBW designs need to include pre-load and large displacement non-linear effects to obtain a reasonable match to test data. With the updated performance and sizing, fuel burn and energy use is reduced by 54% compared to the SUGAR Free current technology Baseline (Goal 60%). Use of the unducted fan version of the engine reduces fuel burn and energy by 56% compared to the Baseline. Technology development roadmaps were updated, and an airport compatibility analysis established feasibility of a folding wing aircraft at existing airports.

  11. Subsonic Ultra Green Aircraft Research: Phase 2. Volume 2; Hybrid Electric Design Exploration

    Science.gov (United States)

    Bradley, Marty K.; Droney, Christopher K.

    2015-01-01

    This report summarizes the hybrid electric concept design, analysis, and modeling work accomplished by the Boeing Subsonic Ultra Green Aircraft Research (SUGAR) team, consisting of Boeing Research and Technology, Boeing Commercial Airplanes, General Electric, and Georgia Tech.Performance and sizing tasks were conducted for hybrid electric versions of a conventional tube-and-wing aircraft and a hybrid wing body. The high wing Truss Braced Wing (TBW) SUGAR Volt was updated based on results from the TBW work (documented separately) and new engine performance models. Energy cost and acoustic analyses were conducted and technology roadmaps were updated for hybrid electric and battery technology. NOx emissions were calculated for landing and takeoff (LTO) and cruise. NPSS models were developed for hybrid electric components and tested using an integrated analysis of superconducting and non-superconducting hybrid electric engines. The hybrid electric SUGAR Volt was shown to produce significant emissions and fuel burn reductions beyond those achieved by the conventionally powered SUGAR High and was able to meet the NASA goals for fuel burn. Total energy utilization was not decreased but reduced energy cost can be achieved for some scenarios. The team was not able to identify a technology development path to meet NASA's noise goals

  12. A comparative study on in vitro osteogenic priming potential of electron spun scaffold PLLA/HA/Col, PLLA/HA, and PLLA/Col for tissue engineering application.

    Science.gov (United States)

    Balaji Raghavendran, Hanumantha Rao; Puvaneswary, Subramaniam; Talebian, Sepehr; Murali, Malliga R; Raman Murali, Malliga; Naveen, Sangeetha V; Vasudevaraj Naveen, Sangeetha; Krishnamurithy, G; McKean, Robert; Kamarul, Tunku

    2014-01-01

    A comparative study on the in vitro osteogenic potential of electrospun poly-L-lactide/hydroxyapatite/collagen (PLLA/HA/Col, PLLA/HA, and PLLA/Col) scaffolds was conducted. The morphology, chemical composition, and surface roughness of the fibrous scaffolds were examined. Furthermore, cell attachment, distribution, morphology, mineralization, extracellular matrix protein localization, and gene expression of human mesenchymal stromal cells (hMSCs) differentiated on the fibrous scaffolds PLLA/Col/HA, PLLA/Col, and PLLA/HA were also analyzed. The electrospun scaffolds with a diameter of 200-950 nm demonstrated well-formed interconnected fibrous network structure, which supported the growth of hMSCs. When compared with PLLA/H%A and PLLA/Col scaffolds, PLLA/Col/HA scaffolds presented a higher density of viable cells and significant upregulation of genes associated with osteogenic lineage, which were achieved without the use of specific medium or growth factors. These results were supported by the elevated levels of calcium, osteocalcin, and mineralization (PCol/HA scaffolds exhibited superior osteoinductivity, when compared with PLLA/Col or PLLA/HA scaffolds. These findings indicated that the fibrous structure and synergistic action of Col and nano-HA with high-molecular-weight PLLA played a vital role in inducing osteogenic differentiation of hMSCs. The data obtained in this study demonstrated that the developed fibrous PLLA/Col/HA biocomposite scaffold may be supportive for stem cell based therapies for bone repair, when compared with the other two scaffolds.

  13. Tras la estela de Colón

    OpenAIRE

    Carmen Martínez Martin

    2011-01-01

    El más trascendental y conocido de los viajes de exploración llevado a cabo en la era de los grandes descubrimientos fue el protagonizado por Cristóbal Colón, quien, con el apoyo de la corona de Castilla, logró atravesar el océano Atlántico y descubrir el nuevo mundo.

  14. Dietary Lecithin Decreases Skeletal Muscle COL1A1 and COL3A1 Gene Expression in Finisher Gilts

    Directory of Open Access Journals (Sweden)

    Henny Akit

    2016-06-01

    Full Text Available The purpose of this study was to investigate the effect of dietary lecithin on skeletal muscle gene expression of collagen precursors and enzymes involved in collagen synthesis and degradation. Finisher gilts with an average start weight of 55.9 ± 2.22 kg were fed diets containing either 0, 4, 20 or 80 g/kg soybean lecithin prior to harvest for six weeks and the rectus abdominis muscle gene expression profile was analyzed by quantitative real-time PCR. Lecithin treatment down-regulated Type I (α1 procollagen (COL1A1 and Type III (α1 procollagen (COL3A1 mRNA expression ( p < 0.05, respectively, indicating a decrease in the precursors for collagen synthesis. The α-subunit of prolyl 4-hydroxylase (P4H mRNA expression also tended to be down-regulated ( p = 0.056, indicating a decrease in collagen synthesis. Decreased matrix metalloproteinase-1 (MMP-1 mRNA expression may reflect a positive regulatory response to the reduced collagen synthesis in muscle from the pigs fed lecithin ( p = 0.035. Lecithin had no effect on tissue inhibitor metalloproteinase-1 (TIMP-1, matrix metalloproteinase-13 (MMP-13 and lysyl oxidase mRNA expression. In conclusion, lecithin down-regulated COL1A1 and COL3A1 as well as tended to down-regulate α-subunit P4H expression. However, determination of muscle collagen content and solubility are required to support the gene functions.

  15. 78 FR 57049 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2013-09-17

    ... Aircraft System Component (JASC)/Air Transport Association (ATA) of America Code 57, Wings. (e) Unsafe... and corrective actions if necessary, and if necessary, a detailed inspection to determine the nut type..., Seattle Aircraft Certification Office, 1601 Lind Avenue SW., Renton, Washington 98057-3356; phone:...

  16. NASA Boeing 757 HIRF test series low power on-the-ground tests

    Energy Technology Data Exchange (ETDEWEB)

    Poggio, A.J.; Pennock, S.T.; Zacharias, R.A.; Avalle, C.A.; Carney, H.L. [National Aeronautics and Space Administration, Langley AFB, VA (United States). Langley Research Center

    1996-08-01

    The data acquisition phase of a program intended to provide data for the validation of computational, analytical, and experimental techniques for the assessment of electromagnetic effects in commercial transports; for the checkout of instrumentation for following test programs; and for the support of protection engineering of airborne systems has been completed. Funded by the NASA Fly-By-Light/ Power-By-Wire Program, the initial phase involved on-the-ground electromagnetic measurements using the NASA Boeing 757 and was executed in the LESLI Facility at the USAF Phillips Laboratory. The major participants in this project were LLNL, NASA Langley Research Center, Phillips Laboratory, and UIE, Inc. The tests were performed over a five week period during September through November, 1994. Measurements were made of the fields coupled into the aircraft interior and signals induced in select structures and equipment under controlled illumination by RF fields. A characterization of the ground was also performed to permit ground effects to be included in forthcoming validation exercises. This report and the associated test plan that is included as an appendix represent a definition of the overall on-the-ground test program. They include descriptions of the test rationale, test layout, and samples of the data. In this report, a detailed description of each executed test is provided, as is the data identification (data id) relating the specific test with its relevant data files. Samples of some inferences from the data that will be useful in protection engineering and EM effects mitigation are also presented. The test plan which guided the execution of the tests, a test report by UIE Inc., and the report describing the concrete pad characterization are included as appendices.

  17. Aircraft Carriers

    DEFF Research Database (Denmark)

    Nødskov, Kim; Kværnø, Ole

    in Asia and will balance the carrier acquisitions of the United States, the United Kingdom, Russia and India. China’s current military strategy is predominantly defensive, its offensive elements being mainly focused on Taiwan. If China decides to acquire a large carrier with offensive capabilities......, then the country will also acquire the capability to project military power into the region beyond Taiwan, which it does not possess today. In this way, China will have the military capability to permit a change of strategy from the mainly defensive, mainland, Taiwan-based strategy to a more assertive strategy...... catapult with which to launch the fi ghter aircraft, not to mention the possible development of a nuclear power plant for the ship. The Russian press has indicated that China is negotiating to buy SU-33 fi ghters, which Russia uses on the Kuznetsov carrier. The SU-33 is, in its modernized version...

  18. Aircraft Electric Secondary Power

    Science.gov (United States)

    1983-01-01

    Technologies resulted to aircraft power systems and aircraft in which all secondary power is supplied electrically are discussed. A high-voltage dc power generating system for fighter aircraft, permanent magnet motors and generators for aircraft, lightweight transformers, and the installation of electric generators on turbine engines are among the topics discussed.

  19. Mutation Analysis of COL1A1 and COL1A2 in Fetuses with Osteogenesis Imperfecta Type II/III.

    Science.gov (United States)

    Wang, Wenbo; Wu, Qichang; Cao, Lin; Sun, Li; Xu, Yasong; Guo, Qiwei

    2015-01-27

    Aim: To analyze COL1A1/2 mutations in prenatal-onset OI for determine the proportion of mutations in type I collagen genes among prenatal onset OI and to provide additional data for genotype-phenotype analyses. Material and Methods: Ten cases of severe fetal short-limb dwarfism detected by antenatal ultrasonography were referred to our center. Before the termination of pregnancy, cordocentesis was performed for fetal karyotype and COL1A1/2 gene sequencing analysis. Postmortem radiographic examination was performed at all instances for definitive diagnosis. Results: COL1A1 and COL1A2 SNP and mutations were identified in all the cases. Among these, one synonymous SNP and four synonymous SNPs were recognized in COL1A1/2, respectively, seven cases have distinct heterozygous mutations and six new COL1A1/2 gene mutations were identified. Conclusion: There has been substantial progress in the identification of the molecular defects responsible for skeletal dysplasias. With the constant increase in the number of identified mutations in COL1A1 and COL1A2, genotype-phenotype correlation is becoming increasingly pertinent. © 2015 S. Karger AG, Basel.

  20. Colágeno na cartilagem osteoartrótica

    Directory of Open Access Journals (Sweden)

    Ana Paula P. Velosa

    2003-06-01

    Full Text Available A cartilagem articular é um tecido altamente especializado, composto por células, os condrócitos, e um conjunto de macromoléculas, como o colágeno e os proteoglicanos. O colágeno é uma proteína fibrilar que garante resistência ao tecido, enquanto os proteoglicanos têm a função de mola biológica, sendo responsáveis pela compressibilidade da cartilagem. A complexa interação entre estas duas proteínas garante a elasticidade. Estas características específicas da cartilagem são essenciais para amortecer as grandes forças de impacto a que as articulações diartrodiais estão submetidas, sem muito gasto de energia, visto tratar-se de um tecido avascular. Em processos artrósicos ocorre um desequilíbrio entre a produção de componentes da matriz extracelular e destruição pelas metaloproteases, levando à degradação e perda do tecido cartilaginoso. A fase inicial da osteoartrose é marcada por perda de fragmentos de proteoglicanos para o líquido sinovial, aumento dos colágenos tipo II e tipo VI, aparecimento dos colágenos I e III, não típicos da cartilagem, e diminuição do colágeno tipo IX, que é importante para manter a integridade da matriz extracelular, além do entumescimento da cartilagem. Como conseqüência, a cartilagem perde suas características específicas, levando a alterações na função articular. A evolução da doença promove diminuição significativa das proteínas, até mesmo do colágeno tipo XI, que tem localização mais interna na estrutura da fibrila heterotípica, e, portanto levando até a exposição do osso. Até o momento, o tratamento da osteoartrose está baseado principalmente no controle da dor e/ou inflamação, não diminuindo ou impedindo a degradação da cartilagem articular. Neste aspecto a perspectiva de tratamento futuro da osteoartrose estaria na utilização de inibidores das metaloproteases associadas a condroprotetores interferindo no "turnover" da cartilagem e

  1. Phenomena of Foamed Concrete under Rolling of Aircraft Wheels

    Science.gov (United States)

    Jiang, Chun-shui; Yao, Hong-yu; Xiao, Xian-bo; Kong, Xiang-jun; Shi, Ya-jie

    2014-04-01

    Engineered Material Arresting System (EMAS) is an effective technique to reduce hazards associated with aircraft overrunning runway. In order to ascertain phenomena of the foamed concrete used for EMAS under rolling of aircraft wheel, a specially designed experimental setup was built which employed Boeing 737 aircraft wheels bearing actual vertical loads to roll through the foamed concrete. A number of experiments were conducted upon this setup. It is discovered that the wheel rolls the concrete in a pure rolling manner and crushes the concrete downwards, instead of crushing it forward, as long as the concrete is not higher than the wheel axle. The concrete is compressed into powder in-situ by the wheel and then is brought to bottom of the wheel. The powder under the wheel is loose and thus is not able to sustain wheel braking. It is also found that after being rolled by the wheel the concrete exhibits either of two states, i.e. either 'crushed through' whole thickness of the concrete or 'crushed halfway', depending on combination of strength of the concrete, thickness of the concrete, vertical load the wheel carries, tire dimension and tire pressure. A new EMAS design concept is developed that if an EMAS design results in the 'crushed through' state for the main gears while the 'crushed halfway' state for the nose gear, the arresting bed would be optimal to accommodate the large difference in strength between the nose gear and the main gear of an aircraft.

  2. Estonian Airi Boeing sattus kaks korda hädaolukorda / Krister Kivi

    Index Scriptorium Estoniae

    Kivi, Krister, 1975-

    2011-01-01

    Estonian Airi Boeing ES-ABL sattus 2011. aasta algus kahel korral ohtlikku olukorda. Lennuamet tegi Estonian Airile ettekirjutuse, kuid seda pole ameti kodulehel avaldatud. Lennufirma kapteni ja lennuohutuse inspektori Andreas Kari, lennuameti selgitusi

  3. Predicting Aircraft Availability

    Science.gov (United States)

    2013-06-01

    dedicate this research to my wife and children. Your patience, love, and understanding enabled me to make the most out of this year at ASAM . I couldn’t...their support, there would not have been anything to analyze. Lastly, I would like to thank all my professors during the ASAM school year. They...Lt Col Dan Mattioda Sponsor: Col MaryAnn Hixon Advanced Study of Air Mobrlity ( ASAM ) I Motivation An update to theM model incorporating the

  4. Aeroelastic Optimization of Generalized Tube and Wing Aircraft Concepts Using HCDstruct Version 2.0

    Science.gov (United States)

    Quinlan, Jesse R.; Gern, Frank H.

    2017-01-01

    Major enhancements were made to the Higher-fidelity Conceptual Design and structural optimization (HCDstruct) tool developed at NASA Langley Research Center (LaRC). Whereas previous versions were limited to hybrid wing body (HWB) configurations, the current version of HCDstruct now supports the analysis of generalized tube and wing (TW) aircraft concepts. Along with significantly enhanced user input options for all air- craft configurations, these enhancements represent HCDstruct version 2.0. Validation was performed using a Boeing 737-200 aircraft model, for which primary structure weight estimates agreed well with available data. Additionally, preliminary analysis of the NASA D8 (ND8) aircraft concept was performed, highlighting several new features of the tool.

  5. Active fault-tolerant control strategy of large civil aircraft under elevator failures

    Directory of Open Access Journals (Sweden)

    Wang Xingjian

    2015-12-01

    Full Text Available Aircraft longitudinal control is the most important actuation system and its failures would lead to catastrophic accident of aircraft. This paper proposes an active fault-tolerant control (AFTC strategy for civil aircraft with different numbers of faulty elevators. In order to improve the fault-tolerant flight control system performance and effective utilization of the control surface, trimmable horizontal stabilizer (THS is considered to generate the extra pitch moment. A suitable switching mechanism with performance improvement coefficient is proposed to determine when it is worthwhile to utilize THS. Furthermore, AFTC strategy is detailed by using model following technique and the proposed THS switching mechanism. The basic fault-tolerant controller is designed to guarantee longitudinal control system stability and acceptable performance degradation under partial elevators failure. The proposed AFTC is applied to Boeing 747-200 numerical model and simulation results validate the effectiveness of the proposed AFTC approach.

  6. Active fault-tolerant control strategy of large civil aircraft under elevator failures

    Institute of Scientific and Technical Information of China (English)

    Wang Xingjian; Wang Shaoping; Yang Zhongwei; Zhang Chao

    2015-01-01

    Aircraft longitudinal control is the most important actuation system and its failures would lead to catastrophic accident of aircraft. This paper proposes an active fault-tolerant control (AFTC) strategy for civil aircraft with different numbers of faulty elevators. In order to improve the fault-tolerant flight control system performance and effective utilization of the control surface, trim-mable horizontal stabilizer (THS) is considered to generate the extra pitch moment. A suitable switching mechanism with performance improvement coefficient is proposed to determine when it is worthwhile to utilize THS. Furthermore, AFTC strategy is detailed by using model following technique and the proposed THS switching mechanism. The basic fault-tolerant controller is designed to guarantee longitudinal control system stability and acceptable performance degradation under partial elevators failure. The proposed AFTC is applied to Boeing 747-200 numerical model and simulation results validate the effectiveness of the proposed AFTC approach.

  7. The BOES spectropolarimeter for Zeeman measurements of stellar magnetic fields

    CERN Document Server

    Kim, Kang-Min; Valyavin, Gennady G; Plachinda, Sergei; Jang, Jeong Gyun; Jang, Be-Ho; Seong, Hyeon Cheol; Lee, Byeong-Cheol; Kang, Dong-Il; Park, Byeong-Gon; Yoon, Tae Seog; Vogt, Steven S

    2007-01-01

    We introduce a new polarimeter installed on the high-resolution fiber-fed echelle spectrograph (called BOES) of the 1.8-m telescope at the Bohyunsan Optical Astronomy Observatory, Korea. The instrument is intended to measure stellar magnetic fields with high-resolution (R $\\sim$ 60000) spectropolarimetric observations of intrinsic polarization in spectral lines. In this paper we describe the spectropolarimeter and present test observations of the longitudinal magnetic fields in some well-studied F-B main sequence magnetic stars (m_v < 8.8^m). The results demonstrate that the instrument has a high precision ability of detecting the fields of these stars with typical accuracies ranged from about 2G to a few tens of gauss.

  8. Rapid evaluation of buildings and infrastructure to accidental and deliberate aircraft impact

    Energy Technology Data Exchange (ETDEWEB)

    Tennant, D., E-mail: tennant@wai.com [Weidlinger Associates, Inc., 6301 Indian School Road NE, Suite 501, Albuquerque, NM 87122 (United States); Levine, H., E-mail: levine@ca.wai.com [Weidlinger Associates, Inc., 399 W. El Camino Real, Suite 200, Mountain View, CA 94040 (United States); Mould, J.; Vaughan, D. [Weidlinger Associates, Inc., 399 W. El Camino Real, Suite 200, Mountain View, CA 94040 (United States)

    2014-04-01

    Recent events involving the impact of large transport aircraft such as the Boeing 767 and 757 into the World Trade Center Towers and the Pentagon have revealed the vulnerability of such structures to terrorist attack. Incidents involving smaller general aviation aircraft have shown the damage that this class of plane can do beyond a protected perimeter. These incidents have elicited inquiries with regard to the effects of impacts of these aircraft types into other critical facilities including aboveground and below ground storage facilities, nuclear power plants, damns and other military and civilian installations. A significant capability to evaluate these threats has been developed during the past 10 years. Small medium and large aircraft have been impacted into buried and aboveground reinforced concrete and light steel frame storage facilities. Both explicit aircraft models and Riera functions (a simplified aircraft impact loading function) have been used to generate an extensive data base. The effects of engines impacting have been studied separately as penetrators. Illustrated in this paper is validation of computational tools for impacts into structures and the initial development of a generalized evaluation tool for rapid evaluation of threats and consequence of aircraft impact into protected facilities.

  9. A plume capture technique for the remote characterization of aircraft engine emissions.

    Science.gov (United States)

    Johnson, G R; Mazaheri, M; Ristovski, Z D; Morawska, L

    2008-07-01

    A technique for capturing and analyzing plumes from unmodified aircraft or other combustion sources under real world conditions is described and applied to the task of characterizing plumes from commercial aircraft during the taxiing phase of the Landing/Take-Off (LTO) cycle. The method utilizes a Plume Capture and Analysis System (PCAS) mounted in a four-wheel drive vehicle which is positioned in the airfield 60 to 180 m downwind of aircraft operations. The approach offers low test turnaround times with the ability to complete careful measurements of particle and gaseous emission factors and sequentially scanned particle size distributions without distortion due to plume concentration fluctuations. These measurements can be performed for individual aircraft movements at five minute intervals. A Plume Capture Device (PCD) collected samples of the naturally diluted plume in a 200 L conductive membrane conforming to a defined shape. Samples from over 60 aircraft movements were collected and analyzed in situ for particulate and gaseous concentrations and for particle size distribution using a Scanning Particle Mobility Sizer (SMPS). Emission factors are derived for particle number, NO(x), and PM2.5 for a widely used commercial aircraft type, Boeing 737 airframes with predominantly CFM56 class engines, during taxiing. The practical advantages of the PCAS include the capacity to perform well targeted and controlled emission factor and size distribution measurements using instrumentation with varying response times within an airport facility, in close proximity to aircraft during their normal operations.

  10. Propulsion controlled aircraft computer

    Science.gov (United States)

    Cogan, Bruce R. (Inventor)

    2010-01-01

    A low-cost, easily retrofit Propulsion Controlled Aircraft (PCA) system for use on a wide range of commercial and military aircraft consists of an propulsion controlled aircraft computer that reads in aircraft data including aircraft state, pilot commands and other related data, calculates aircraft throttle position for a given maneuver commanded by the pilot, and then displays both current and calculated throttle position on a cockpit display to show the pilot where to move throttles to achieve the commanded maneuver, or is automatically sent digitally to command the engines directly.

  11. Cisto gigante de colédoco Giant choledochal cyst

    Directory of Open Access Journals (Sweden)

    Olival Cirilo Lucena da Fonseca-Neto

    2007-12-01

    Full Text Available INTRODUÇÃO: A doença cística das vias biliares é anomalia congênita que pode acometer as vias biliares intra e/ou extra-hepáticas. A extra-hepática inclui os cistos de colédoco e a intra-hepática é conhecida por Doença de Caroli. Os cistos de colédoco de tamanho gigante são muito raros. OBJETIVO: Relatar o caso de um cisto de colédoco de tamanho gigante em uma paciente feminina. RELATO DE CASO: Mulher de 19 anos foi admitida com história de icterícia e acolia fecal há sete dias. Referia dor epigástrica associada com ingestão de dieta rica em gordura. Nos antecedentes pessoais relatou dois episódios de icterícia, aos 8 e 14 anos, que progrediram espontaneamente. No exame físico apresentava icterícia (+3/+4 e uma massa palpável indolor em mesogástrio foram os únicos achados. A ultrassonografia demonstrou grande formação cística de paredes finas adjacente ao hepatocolédoco, pâncreas e rim direito que media 18,5 x 10,2 cm. A colangioressonância confirmou o grande cisto de colédoco e hepatojejunoanastomose em "Y" de Roux após excisão do cisto e colecistectomia foi realizada. A formação cística media 20 x 15,5 x 12,5 cm e com um volume médio de 1000 mL. A paciente encontra-se em acompanhamento ambulatorial sem alterações hepatobiliares após o sétimo mês da operação. CONCLUSÃO: O cisto de colédoco deve fazer parte do diagnóstico diferencial em pacientes adultos jovens com icterícia e massa palpável; no entanto, a diferenciação entre ele e neoplasia maligna deve ser pesquisada.BACKGROUND: Choledochal cyst represents a rare congenital anomaly, eventually associated with intra and extrahepatic biliary tract disorders. Extrahepatic diseases include choledochal cysts and congenital dilation of the lower intrahepatic bile duct is known as Caroli's disease. Giant choledochal cyst constitutes a very rare abnormality. AIM:To report a giant choledochal cyst in a female patient. CASE REPORT: A 19-year

  12. A Study on the Dynamic Mechanism of the Formation of Mesoscale Vortex in Col Field

    Institute of Scientific and Technical Information of China (English)

    JIANG Yongqiang; WANG Yuan; HUANG Hong

    2012-01-01

    The mesoscale vortex associated with a mesoscale low-level jet (mLLJ) usually causes heavy rainfall in the col field.The col field is defined as a region between two highs and two lows,with the isobaric surface similar to a col.Using a two-dimensional shallow water model,the meso-β scale vortex couplets (MβVCs)induced by eight types of mesoscale wind perturbations in an ideal col field were numerically simulated.With the sizes of ~100 km,the MβVCs induced by northerly perturbation (NP) and southerly perturbation (SP)moved toward the col point.The sizes of MβVCs induced by southwesterly perturbation (SWP),southeasterly perturbation (SEP),northwesterly perturbation (NWP),and northeasterly perturbation (NEP) were relatively small for the perturbations moving toward dilatation axis.The MβVC induced by easterly perturbation (EP) and westerly perturbation (WP) could not develop because they quickly moved away from the col point,before the circulation could form.The size of the circulation was determined by the distance between the vortex and the col point.The closer to the col point the vortex was,the larger the size of vortex.The comparisons of maximum vorticity and vorticity root mean square error (RMSE) of the NP,the SWP,and the WP show that the maximum vorticity and the vorticity RMSE of the NP decreased slower than other perturbations.Therefore,the weak environment of the col field favors the maintenance of vorticity and the formation of vortex.When a mesoscalc vortex forms near the col point or moves toward the col point,it may maintain a quasi-stationary state in the stable col field.

  13. Unmanned Aircraft System / Remotely Piloted Aircraft (UAS/RPA) Human Factors and Human Systems Integration Research Workshop Held in Dayton, Ohio on November 8-9, 2011

    Science.gov (United States)

    2012-05-25

    WWII, while it may take only 10 minutes today. At the same time there has been a vast reduction in the number of aircraft and aircrew needed to...with functions that are not common to their platform. Another UAS project conducted at NAWC-TSD was a heuristic -based usability analysis of Open...hours outside the box. The brief by Lt Col Tvaryanas continued by discussing current UAS shiftwork heuristics and compared the effects of rapid vs

  14. 红花水煎液内服对硬皮小鼠皮肤COL-Ⅰ、COL-Ⅲ表达的影响

    Institute of Scientific and Technical Information of China (English)

    杨欢欢; 吕军影; 黄李平; 严煜林; 何雪萍

    2014-01-01

    目的 观察红花对硬皮小鼠皮肤COL-Ⅰ、COL-Ⅲ表达的影响,探讨红花抗皮肤纤维化的作用机制.方法 采用博来霉素诱导建立硬皮小鼠模型,分别采用生理盐水(模型组)、青霉胺、低中高不同剂量红花水煎液内服治疗硬皮小鼠,共28 d.对照组小鼠背部皮下注射磷酸盐缓冲液.HE染色观察皮肤病理改变并测量真皮厚度,免疫组化检测COL-Ⅰ、COL-Ⅲ的含量表达.结果 造模各组硬皮小鼠真皮厚度增厚,纤维增粗、膨大,数量增多,排列紊乱,COL-Ⅰ、COL-Ⅲ的含量表达降低,模型组尤为显著,与对照组比较差异均有统计学意义(P<0.05);与模型组比较,青霉胺和红花水煎液各剂量组药物干预后真皮厚度及COL-Ⅰ、COL-Ⅲ的表达均有不同程度降低,差异显著(P<0.05);与青霉胺组比较,红花水煎液中、高剂量组真皮厚度及COL-Ⅰ、COL-Ⅲ的表达明显降低,差异有统计学意义(P<0.05).结论 红花水煎液内服可降低硬皮小鼠皮肤COL-Ⅰ、COL-Ⅲ的表达,从而改善硬皮小鼠皮肤纤维化程度.

  15. Unmanned aircraft systems

    Science.gov (United States)

    Unmanned platforms have become increasingly more common in recent years for acquiring remotely sensed data. These aircraft are referred to as Unmanned Airborne Vehicles (UAV), Remotely Piloted Aircraft (RPA), Remotely Piloted Vehicles (RPV), or Unmanned Aircraft Systems (UAS), the official term used...

  16. Subsonic Ultra Green Aircraft Research: Phase II- Volume III-Truss Braced Wing Aeroelastic Test Report

    Science.gov (United States)

    Bradley, Marty K.; Allen, Timothy J.; Droney, Christopher

    2014-01-01

    This Test Report summarizes the Truss Braced Wing (TBW) Aeroelastic Test (Task 3.1) work accomplished by the Boeing Subsonic Ultra Green Aircraft Research (SUGAR) team, which includes the time period of February 2012 through June 2014. The team consisted of Boeing Research and Technology, Boeing Commercial Airplanes, Virginia Tech, and NextGen Aeronautics. The model was fabricated by NextGen Aeronautics and designed to meet dynamically scaled requirements from the sized full scale TBW FEM. The test of the dynamically scaled SUGAR TBW half model was broken up into open loop testing in December 2013 and closed loop testing from January 2014 to April 2014. Results showed the flutter mechanism to primarily be a coalescence of 2nd bending mode and 1st torsion mode around 10 Hz, as predicted by analysis. Results also showed significant change in flutter speed as angle of attack was varied. This nonlinear behavior can be explained by including preload and large displacement changes to the structural stiffness and mass matrices in the flutter analysis. Control laws derived from both test system ID and FEM19 state space models were successful in suppressing flutter. The control laws were robust and suppressed flutter for a variety of Mach, dynamic pressures, and angle of attacks investigated.

  17. An Energy Efficient MAC Proto col for Linear WSNs

    Institute of Scientific and Technical Information of China (English)

    DAI Guoyong; MIAO Chunyu; YING Kezhen; WANG Kai; CHEN Qingzhang

    2015-01-01

    Wireless sensor networks (WSNs) have been employed as an ideal solution in many applications for data gathering in harsh environment. Energy consumption is a key issue in wireless sensor networks since nodes are often battery operated. Medium access control (MAC) pro-tocol plays an important role in energy efficiency in wire-less sensor networks because nodes’ access to the shared medium is coordinated by the MAC layer. An energy ef-ficient MAC protocol is designed for data gathering in linear wireless sensor networks. In order to enhance the performance, when a source node transmits data to the sink, proper relay nodes are selected for forwarding data according to the energy consumption factor and residual energy balance factor. Some simulation experiments are conducted and the results show that, the proposed proto-col provides better energy efficiency and long lifetime than the existing DMAC protocol.

  18. EuroCirCol kick-off event

    CERN Multimedia

    Hardre, Julie

    2015-01-01

    The EuroCirCol (http://cern.ch/eurocircol) kick-off event at CERN on June 2-4 brought together 62 participants to constitute governance bodies, commit to the project plan and align the organisation, structures and processes of 16 institutions from 10 countries. The goal of the project is to conceive a post-LHC research infrastructure around a 100 km circular energy-frontier hadron collider capable of reaching 100 TeV collisions. The project officially started on June 1 and will run for four years. The total estimated budget of 11.2 million Euros includes a 2.99 million Euro contribution from the Horizon 2020 programme on developing new world-class research infrastructures (http://cordis.europa.eu/project/rcn/194962_en.html).

  19. Differentiation of Col I and Col III isoforms in stromal models of ovarian cancer by analysis of second harmonic generation polarization and emission directionality.

    Science.gov (United States)

    Tilbury, Karissa; Lien, Chi-Hsiang; Chen, Shean-Jen; Campagnola, Paul J

    2014-01-21

    A profound remodeling of the extracellular matrix occurs in many epithelial cancers. In ovarian cancer, the minor collagen isoform of Col III becomes upregulated in invasive disease. Here we use second harmonic generation (SHG) imaging microscopy to probe structural differences in fibrillar models of the ovarian stroma comprised of mixtures of Col I and III. The SHG intensity and forward-backward ratios decrease with increasing Col III content, consistent with decreased phasematching due to more randomized structures. We further probe the net collagen α-helix pitch angle within the gel mixtures using what is believed to be a new pixel-based polarization-resolved approach that combines and extends previous analyses. The extracted pitch angles are consistent with those of peptide models and the method has sufficient sensitivity to differentiate Col I from the Col I/Col III mixtures. We further developed the pixel-based approach to extract the SHG signal polarization anisotropy from the same polarization-resolved image matrix. Using this approach, we found that increased Col III results in decreased alignment of the dipole moments within the focal volume. Collectively, the SHG measurements and analysis all indicate that incorporation of Col III results in decreased organization across several levels of collagen organization. Furthermore, the findings suggest that the collagen isoforms comingle within the same fibrils, in good agreement with ultrastructural data. The pixel-based polarization analyses (both excitation and emission) afford determination of structural properties without the previous requirement of having well-aligned fibers, and the approaches should be generally applicable in tissue.

  20. COL4A3 expression correlates with pathogenesis, pathologic behaviors, and prognosis of gastric carcinomas.

    Science.gov (United States)

    Nie, Xiao-cui; Wang, Jian-Ping; Zhu, Wan; Xu, Xiao-yan; Xing, Ya-nan; Yu, Miao; Liu, Yun-peng; Takano, Yasuo; Zheng, Hua-chuan

    2013-01-01

    COL4A3 protein belongs to type IV collagen family and is closely linked to kidney diseases and cancer. To clarify the roles of COL4A3 in gastric carcinogenesis and subsequent progression, its expression was examined by immunohistochemistry on tissue microarrays containing gastric carcinomas, adjacent intestinal metaplasia, pure intestinal metaplasia, and gastritis. Gastric carcinoma tissue and cell lines were studied for COL4A3 expression by Western blotting and reverse transcription-polymerase chain reaction. We found that COL4A3 was differentially expressed in GES-1, AGS, BGC-823, GT-3 TKB, HGC-27, KATO-III, MGC-803, MKN28, MKN45, SCH, SGC-7901, and STKM-2 at both messenger RNA and protein levels. Carcinomas showed statistically lower COL4A3 expression than matched nonneoplastic mucosa (P carcinoma (P carcinoma than gastritis (P carcinomas regardless of invasion into the muscularis propria (P carcinomas showed COL4A3 expression. Kaplan-Meier analysis indicated that COL4A3 expression was negatively associated with a favorable prognosis of overall, advanced, and intestinal-type gastric carcinomas (P carcinoma. COL4A3 overexpression might be used as a marker of gastric intestinal metaplasia and mucinous and signet ring cell carcinoma.

  1. Development and validation of bonded composite doubler repairs for commercial aircraft.

    Energy Technology Data Exchange (ETDEWEB)

    Roach, Dennis Patrick; Rackow, Kirk A.

    2007-07-01

    A typical aircraft can experience over 2,000 fatigue cycles (cabin pressurizations) and even greater flight hours in a single year. An unavoidable by-product of aircraft use is that crack, impact, and corrosion flaws develop throughout the aircraft's skin and substructure elements. Economic barriers to the purchase of new aircraft have placed even greater demands on efficient and safe repair methods. The use of bonded composite doublers offers the airframe manufacturers and aircraft maintenance facilities a cost effective method to safely extend the lives of their aircraft. Instead of riveting multiple steel or aluminum plates to facilitate an aircraft repair, it is now possible to bond a single Boron-Epoxy composite doubler to the damaged structure. The FAA's Airworthiness Assurance Center at Sandia National Labs (AANC), Boeing, and Federal Express completed a pilot program to validate and introduce composite doubler repair technology to the U.S. commercial aircraft industry. This project focused on repair of DC-10 fuselage structure and its primary goal was to demonstrate routine use of this repair technology using niche applications that streamline the design-to-installation process. As composite doubler repairs gradually appear in the commercial aircraft arena, successful flight operation data is being accumulated. These commercial aircraft repairs are not only demonstrating the engineering and economic advantages of composite doubler technology but they are also establishing the ability of commercial maintenance depots to safely adopt this repair technique. This report presents the array of engineering activities that were completed in order to make this technology available for widespread commercial aircraft use. Focused laboratory testing was conducted to compliment the field data and to address specific issues regarding damage tolerance and flaw growth in composite doubler repairs. Fatigue and strength tests were performed on a simulated wing

  2. Ares I Aerodynamic Testing at the Boeing Polysonic Wind Tunnel

    Science.gov (United States)

    Pinier, Jeremy T.; Niskey, Charles J.; Hanke, Jeremy L.; Tomek, William G.

    2011-01-01

    Throughout three full design analysis cycles, the Ares I project within the Constellation program has consistently relied on the Boeing Polysonic Wind Tunnel (PSWT) for aerodynamic testing of the subsonic, transonic and supersonic portions of the atmospheric flight envelope (Mach=0.5 to 4.5). Each design cycle required the development of aerodynamic databases for the 6 degree-of-freedom (DOF) forces and moments, as well as distributed line-loads databases covering the full range of Mach number, total angle-of-attack, and aerodynamic roll angle. The high fidelity data collected in this facility has been consistent with the data collected in NASA Langley s Unitary Plan Wind Tunnel (UPWT) at the overlapping condition ofMach=1.6. Much insight into the aerodynamic behavior of the launch vehicle during all phases of flight was gained through wind tunnel testing. Important knowledge pertaining to slender launch vehicle aerodynamics in particular was accumulated. In conducting these wind tunnel tests and developing experimental aerodynamic databases, some challenges were encountered and are reported as lessons learned in this paper for the benefit of future crew launch vehicle aerodynamic developments.

  3. Chemically modified tetracycline (COL-3) improves survival if given 12 but not 24 hours after cecal ligation and puncture.

    Science.gov (United States)

    Halter, Jeffrey M; Pavone, Lucio A; Steinberg, Jay M; Gatto, Louis A; DiRocco, Joseph; Landas, Steve; Nieman, Gary F

    2006-12-01

    Sepsis can result in excessive and maladaptive inflammation that is responsible for more than 215,00 deaths per year in the United State alone. Current strategies for reducing the morbidity and mortality associated with sepsis rely on treatment of the syndrome rather than prophylaxis. We have been investigating a modified tetracycline, COL-3, which can be given prophylactically to patients at high risk for developing sepsis. Our group has shown that COL-3 is very effect at preventing the sequelae of sepsis if given before or immediately after injury in both rat and porcine sepsis models. In this study, we wanted to determine the "treatment window" for COL-3 after injury at which it remains protective. Sepsis was induced by cecal ligation and puncture (CLP). Rats were anesthetized and placed into five groups: CLP (n = 20) = CLP without COL-3, sham (n = 5) = surgery without CLP or COL-3, COL3@6h (n = 10) = COL-3 given by gavage 6 h after CLP, COL3@12h (n = 10) = COL-3 given by gavage 12 h after CLP, and COL3@24h (n = 20) = COL-3 given by gavage 24 h after CLP. COL-3 that was given at 6 and 12 h after CLP significantly improved survival as compared with the CLP and the CLP@24h groups. Improved survival was associated with a significant improvement in lung pathology assessed morphologically. These data suggest that COL-3 can be given up to 12 h after trauma and remain effective.

  4. 78 FR 46538 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-08-01

    ...-resistant access doors. This proposed AD would require an inspection of the left- and right-hand wing fuel... Engineer, Propulsion Branch, ANM-140S, FAA, Seattle Aircraft Certification Office, 1601 Lind Avenue SW... identified previously is likely to exist or develop in other products of these same type designs. Proposed...

  5. 78 FR 22802 - Airworthiness Directives; the Boeing Company Airplanes

    Science.gov (United States)

    2013-04-17

    ... in-flight resulting in decreased airplane control and performance, possible runway excursions, and... Tran, Aerospace Engineer, Propulsion Branch, ANM-140S, Seattle Aircraft Certification Office (ACO), FAA... motor switcher or shutoff solenoid valves because of overheating. This let the air motor shutoff...

  6. NASA-UVa light aerospace alloy and structures technology program supplement: Aluminum-based materials for high speed aircraft

    Science.gov (United States)

    Starke, E. A., Jr. (Editor)

    1995-01-01

    This report on the NASA-UVa light aerospace alloy and structure technology program supplement: Aluminum-Based Materials for High Speed Aircraft covers the period from July 1, 1992. The objective of the research is to develop aluminum alloys and aluminum matrix composites for the airframe which can efficiently perform in the HSCT environment for periods as long as 60,000 hours (certification for 120,000 hours) and, at the same time, meet the cost and weight requirements for an economically viable aircraft. Current industry baselines focus on flight at Mach 2.4. The research covers four major materials systems: (1) Ingot metallurgy 2XXX, 6XXX, and 8XXX alloys, (2) Powder metallurgy 2XXX alloys, (3) Rapidly solidified, dispersion strengthened Al-Fe-X alloys, and (4) Discontinuously reinforced metal matrix composites. There are ten major tasks in the program which also include evaluation and trade-off studies by Boeing and Douglas aircraft companies.

  7. Transcriptional regulation of acetylcholinesterase-associated collagen ColQ in fast- and slow-twitch muscle fibers.

    Science.gov (United States)

    Ting, Annie K L; Siow, Nina L; Kong, L W; Tsim, Karl W K

    2005-12-15

    The presence of a collagenous protein (ColQ) characterizes the collagen-tailed forms of acetylcholinesterase (AChE) and butyrylcholinesterase at vertebrate neuromuscular junctions, which is tethered in the synaptic basal lamina. ColQ subunits, differing mostly by their signal sequences, are encoded by transcripts ColQ-1 and ColQ-1a, which are differentially expressed in slow- and fast-twitch muscles in mammals, respectively. Both ColQ transcripts are derived from a single COLQ gene. Transcripts encoding ColQ increased during myogenic differentiation of C2C12 cells; the increase was in parallel with AChE catalytic subunit. Quantitative PCR analysis indicated that the increase during the myotube formation was due to the up regulation of ColQ-1 transcript instead of ColQ-1a. In order to reveal the regulatory mechanism of ColQ transcripts, two distinct promoters, pColQ-1 and pColQ-1a, were isolated from human COLQ gene. The ColQ promoters showed a muscle fiber type-specific expression pattern, and which was in line with the expression of endogenous transcript. After in vivo DNA transfection, pColQ-1 showed strong activity in slow-twitch muscle (e.g. soleus), while pColQ-1a was preferably expressed in fast-twitch muscle (e.g. tibialis). Mutation analysis of the ColQ promoters suggested that the muscle fiber type-specific expression pattern of ColQ transcripts was regulated by a slow upsteam regulatory element (SURE) and a fast intronic regulatory element (FIRE). These results explain the specific expression patterns of collagen-tailed AChE in slow and fast muscle fibers.

  8. Turboelectric Distributed Propulsion in a Hybrid Wing Body Aircraft

    Science.gov (United States)

    Felder, James L.; Brown, Gerald V.; DaeKim, Hyun; Chu, Julio

    2011-01-01

    The performance of the N3-X, a 300 passenger hybrid wing body (HWB) aircraft with turboelectric distributed propulsion (TeDP), has been analyzed to see if it can meet the 70% fuel burn reduction goal of the NASA Subsonic Fixed Wing project for N+3 generation aircraft. The TeDP system utilizes superconducting electric generators, motors and transmission lines to allow the power producing and thrust producing portions of the system to be widely separated. It also allows a small number of large turboshaft engines to drive any number of propulsors. On the N3-X these new degrees of freedom were used to (1) place two large turboshaft engines driving generators in freestream conditions to maximize thermal efficiency and (2) to embed a broad continuous array of 15 motor driven propulsors on the upper surface of the aircraft near the trailing edge. That location maximizes the amount of the boundary layer ingested and thus maximizes propulsive efficiency. The Boeing B777-200LR flying 7500 nm (13890 km) with a cruise speed of Mach 0.84 and an 118100 lb payload was selected as the reference aircraft and mission for this study. In order to distinguish between improvements due to technology and aircraft configuration changes from those due to the propulsion configuration changes, an intermediate configuration was included in this study. In this configuration a pylon mounted, ultra high bypass (UHB) geared turbofan engine with identical propulsion technology was integrated into the same hybrid wing body airframe. That aircraft achieved a 52% reduction in mission fuel burn relative to the reference aircraft. The N3-X was able to achieve a reduction of 70% and 72% (depending on the cooling system) relative to the reference aircraft. The additional 18% - 20% reduction in the mission fuel burn can therefore be attributed to the additional degrees of freedom in the propulsion system configuration afforded by the TeDP system that eliminates nacelle and pylon drag, maximizes boundary

  9. Collimation and material science studies (ColMat) at GSI.

    CERN Document Server

    Stadlmann, J; Kollmus, H; Krause, M; Mustafin, E; Petzenhauser, I; Spiller, P; Strasik, I; Tahir, N; Tomut, M; Trautmann, C

    2010-01-01

    Within the frame of the EuCARD program, the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt is performing accelerator R&D in workpackage 8: ColMat. The coordinated effort is focussed on materials aspects important for building the FAIR accelerator facility at GSI and the LHC upgrade at CERN. Accelerator components and especially protection devices have to be operated in high dose environments. The radiation hazard occurs either by the primary proton and ion beams or the secondary radiation after initial beam loss. Detailed numerical simulations have been carried out to study the damage caused to solid targets by the full impact of the LHC beam as well as the SPS beam. Tungsten, copper and graphite as possible collimator materials have been studied. Experimental an theoretical studies on radiation damage on materials used for the LHC upgrade and the FAIR accelerators are performed at the present GSI experimental facilities. Technical decisions based on these results will have an impact on the F...

  10. Downregulation of Col1a1 induces differentiation in mouse spermatogonia

    Institute of Scientific and Technical Information of China (English)

    Sun-Hong Chen; Ding Li; Chen Xu

    2012-01-01

    Col1a1 (one of the subunit of collagen type Ⅰ) is a collagen,which belongs to a family of extracellular matrix (ECM) proteins that play an important role in cellular proliferation and differentiation.However,the role of Col1a1 in spermatogenesis,especially in the control of proliferation and differentiation of spermatogonial stem cells (SSCs),remains unknown.In this study,we explored effects of downregulation of Col1a1 on differentiation and proliferation of mouse spermatogonia.Loss-of-function study revealed that Oct4 and Plzf,markers of SSC self-renewal,were significantly decreased,whereas the expression of c-kit and haprin,hallmarks of SSC differentiation,was enhanced after Col1a1 knockdown.Cell cycle analyses indicated that two-thirds of spermatogonia were arrested in S phase after Col1a1 knockdown.In vivo experiments,DNA injection and electroporation of the testes showed that spermatogonia self-renewal ability was impaired remarkably with the loss-of-function of Col1a1.Our data suggest that silencing of Col1a1 can suppress spermatogonia self-renewal and promote spermatogonia differentiation.

  11. Aircraft Noise Prediction

    OpenAIRE

    2014-01-01

    This contribution addresses the state-of-the-art in the field of aircraft noise prediction, simulation and minimisation. The point of view taken in this context is that of comprehensive models that couple the various aircraft systems with the acoustic sources, the propagation and the flight trajectories. After an exhaustive review of the present predictive technologies in the relevant fields (airframe, propulsion, propagation, aircraft operations, trajectory optimisation), the paper add...

  12. Wavelength-Dependent Second Harmonic Generation Circular Dichroism for Differentiation of Col I and Col III Isoforms in Stromal Models of Ovarian Cancer Based on Intrinsic Chirality Differences.

    Science.gov (United States)

    Campbell, Kirby R; Campagnola, Paul J

    2017-03-02

    Extensive remodeling of the extracellular matrix (ECM) occurs in many epithelial cancers. For example, in ovarian cancer, upregulation of collagen isoform type III has been linked to invasive forms of the disease, and this change may be a potential biomarker. To examine this possibility, we implemented wavelength-dependent second harmonic generation circular dichroism (SHG-CD) imaging microscopy to quantitatively determine changes in chirality in ECM models comprised of different Col I/Col III composition. In these models, Col III was varied between 0 and 40%, and we found increasing Col III results in reduced net chirality, consistent with structural biology studies of Col I and III in tissues where the isoforms comingle in the same fibrils. We further examined the wavelength dependence of the SHG-CD to both optimize the response and gain insight into the underlying mechanism. We found using shorter SHG excitation wavelengths resulted in increased SHG-CD sensitivity, where this is consistent with the electric-dipole-coupled oscillator model suggested previously for the nonlinear chirality response from thin films. Moreover, the sensitivity is further consistent with the wavelength dependency of SHG intensity fit to a two-state model of the two-photon absorption in collagen. We also provide experimental calibration protocols to implement the SHG-CD modality on a laser scanning microscope. We last suggest that the technique has broad applicability in probing a wide range of diseased states with changes in collagen molecular structure.

  13. Engine Company Evaluation of Feasibility of Aircraft Retrofit Water-Injected Turbomachines

    Science.gov (United States)

    Becker, Arthur

    2006-01-01

    This study supports the NASA Glenn Research Center and the U.S. Air Force Research Laboratory in their efforts to evaluate the effect of water injection on aircraft engine performance and emissions. In this study, water is only injected during the takeoff and initial climb phase of a flight. There is no water injection during engine start or ground operations, nor during climb, cruise, descent, or landing. This study determined the maintenance benefit of water injection during takeoff and initial climb and evaluated the feasibility of retrofitting a current production engine, the PW4062 (Pratt & Whitney, East Hartford, CT), with a water injection system. Predicted NO(x) emissions based on a 1:1 water-tofuel ratio are likely to be reduced between 30 to 60 percent in Environmental Protection Agency parameter (EPAP). The maintenance cost benefit for an idealized combustor water injection system installed on a PW4062 engine in a Boeing 747-400ER aircraft (The Boeing Company, Chicago, IL) is computed to be $22 per engine flight hour (EFH). Adding water injection as a retrofit kit would cost up to $375,000 per engine because of the required modifications to the fuel system and addition of the water supply system. There would also be significant nonrecurring costs associated with the development and certification of the system that may drive the system price beyond affordability.

  14. Cable Tensiometer for Aircraft

    Science.gov (United States)

    Nunnelee, Mark (Inventor)

    2008-01-01

    The invention is a cable tensiometer that can be used on aircraft for real-time, in-flight cable tension measurements. The invention can be used on any aircraft cables with high precision. The invention is extremely light-weight, hangs on the cable being tested and uses a dual bending beam design with a high mill-volt output to determine tension.

  15. “热敷药”对硬皮病小鼠模型COL-Ⅰ、COL-Ⅲ蛋白含量的影响%Effects of Refu Yao on Mice Models with Scleroderma of COL-Ⅰ and COL- Ⅲ

    Institute of Scientific and Technical Information of China (English)

    闫小宁; 韩世荣; 李文彬; 李美红; 刘燕婷

    2011-01-01

    Objective To study the effects of traditional Chinese herbs Refu Yao on mice models with scleroderma of COL-I and COL- M. Methods 60 BALB/C mice models were randomly divided into six groups with ten mice in each group. Mice models with scleroderma were established in mice by repeated local injections of bleomycin for five weeks. Then 10%, 20% and 40% Refu Yao were given to the mice models of high -concentration group, mid -concentration group and low concentration group for one month. Than the pathological change of skin tissue was observed, and the COL-I and COL- DI expression in lesions were detected by immunohistochemical detection. Results Compared with the model group, there was significant improvement in the skin tissue of high-concentration group and mid-concentration group. The content of COL-I and COL- ID was decreased remarkably by Refu Yao, and the difference was significance (PCOL-I and COL- DI, and it can also improve fibrosis in the skin.%目的 观察“热敷药”对硬皮病小鼠模型Ⅰ型胶原、Ⅲ型胶原(COL-Ⅰ、COL-Ⅲ)含量的影响.方法 60只BALB/c小鼠按照随机原则分为空白组、模型组、西药组、小浓度组、中浓度组、大浓度组各10只,采用博莱霉素皮下注射形成硬皮病模型,造模完成后,根据分组分别给予10%、20%、40%“热敷药”药糊及肝素钠软膏外用,1次/d,连续1个月,空白组及模型组不用药.完成后观察各组皮肤组织病理变化,免疫组化检测皮损COL-Ⅰ、COL-Ⅲ蛋白含量.结果 与模型组相比较,高、中浓度组硬皮痛小鼠模型COL-Ⅰ、COL-Ⅲ蛋白含量明显降低,差异较显著(P<0.05);结论 “热敷药”具有改善硬皮病小鼠模型皮肤硬化,降低COL-Ⅰ、COL-Ⅲ的作用.

  16. 75 FR 75 - Special Conditions: Boeing Model 787-8 Airplane; Overhead Crew Rest Compartment

    Science.gov (United States)

    2010-01-04

    ... Model 787-8 Airplane; Overhead Crew Rest Compartment AGENCY: Federal Aviation Administration (FAA), DOT... installation of an overhead crew rest compartment. The applicable airworthiness regulations do not contain... Design Features Crew rest compartments have been installed and certificated on several Boeing...

  17. 75 FR 8279 - Airworthiness Directives; The Boeing Company Model 747 Airplanes

    Science.gov (United States)

    2010-02-24

    .... For airplanes with previously installed repairs, before further flight, do rework (i.e., replace any... contact Boeing for repair or rework data, the data must be approved in accordance with the procedures specified in paragraph (x) of this AD and the repair or rework must be done before further flight. (i)...

  18. The Boeing Company's Manufacturing Technology Student Internship. Evaluation Report (1994-95).

    Science.gov (United States)

    Wang, Changhua; Owens, Thomas R.

    An evaluation was conducted of the Boeing Company's summer internship program for students enrolled in a manufacturing technology program after grades 11, 12, and 13 (first year of community college). The evaluation included the following activities: a review of documents describing the internship structure, student selection process, and…

  19. The Boeing Company gives $50,000 to Student Design Team Endowment

    OpenAIRE

    Nystrom, Lynn A.

    2007-01-01

    Last April, Virginia Tech's Student Engineers' Council (SEC) announced the creation of an endowment to benefit student design teams at the university. With the beginning of the fall semester, The Boeing Company increased the size of this endowment with a gift of $50,000 from its Global Corporate Citizenship (GCC) disaster relief team budget.

  20. The Boeing Company's Manufacturing Technology Student Internship. Final Evaluation Report for 1996.

    Science.gov (United States)

    Owens, Tom

    A study evaluated The Boeing Company's Student Internship Program for students enrolled in a manufacturing technology program. The programs in the Seattle (Washington) and Portland (Oregon) areas provided students with three progressive internship levels offered in the summers of grades 11, 12, and 13 (the first year of community college). The…

  1. The Boeing Company Applied Academics Project Evaluation: Year Four. Evaluation Report.

    Science.gov (United States)

    Wang, Changhua; Owens, Thomas R.

    This paper describes fourth-year outcomes (1993-94) of the Boeing Company-funded Applied Academics Project. Since the 1990-91 school year, the company has provided funds to improve and expand applied academics in 60 Washington high schools. Data were collected from pre- and post-surveys of students enrolled in the project's Applied Mathematics…

  2. Computed and Experimental Flutter/LCO Onset for the Boeing Truss-Braced Wing Wind-Tunnel Model

    Science.gov (United States)

    Bartels, Robert E.; Scott, Robert C.; Funk, Christie J.; Allen, Timothy J.; Sexton, Bradley W.

    2014-01-01

    This paper presents high fidelity Navier-Stokes simulations of the Boeing Subsonic Ultra Green Aircraft Research truss-braced wing wind-tunnel model and compares the results to linear MSC. Nastran flutter analysis and preliminary data from a recent wind-tunnel test of that model at the NASA Langley Research Center Transonic Dynamics Tunnel. The simulated conditions under consideration are zero angle of attack, so that structural nonlinearity can be neglected. It is found that, for Mach number greater than 0.78, the linear flutter analysis predicts flutter onset dynamic pressure below the wind-tunnel test and that predicted by the Navier-Stokes analysis. Furthermore, the wind-tunnel test revealed that the majority of the high structural dynamics cases were wing limit cycle oscillation (LCO) rather than flutter. Most Navier-Stokes simulated cases were also LCO rather than hard flutter. There is dip in the wind-tunnel test flutter/LCO onset in the Mach 0.76-0.80 range. Conditions tested above that Mach number exhibited no aeroelastic instability at the dynamic pressures reached in the tunnel. The linear flutter analyses do not show a flutter/LCO dip. The Navier-Stokes simulations also do not reveal a dip; however, the flutter/LCO onset is at a significantly higher dynamic pressure at Mach 0.90 than at lower Mach numbers. The Navier-Stokes simulations indicate a mild LCO onset at Mach 0.82, then a more rapidly growing instability at Mach 0.86 and 0.90. Finally, the modeling issues and their solution related to the use of a beam and pod finite element model to generate the Navier-Stokes structure mode shapes are discussed.

  3. TCV software test and validation tools and technique. [Terminal Configured Vehicle program for commercial transport aircraft operation

    Science.gov (United States)

    Straeter, T. A.; Williams, J. R.

    1976-01-01

    The paper describes techniques for testing and validating software for the TCV (Terminal Configured Vehicle) program which is intended to solve problems associated with operating a commercial transport aircraft in the terminal area. The TCV research test bed is a Boeing 737 specially configured with digital computer systems to carry out automatic navigation, guidance, flight controls, and electronic displays research. The techniques developed for time and cost reduction include automatic documentation aids, an automatic software configuration, and an all software generation and validation system.

  4. Aircraft operations management manual

    Science.gov (United States)

    1992-01-01

    The NASA aircraft operations program is a multifaceted, highly diverse entity that directly supports the agency mission in aeronautical research and development, space science and applications, space flight, astronaut readiness training, and related activities through research and development, program support, and mission management aircraft operations flights. Users of the program are interagency, inter-government, international, and the business community. This manual provides guidelines to establish policy for the management of NASA aircraft resources, aircraft operations, and related matters. This policy is an integral part of and must be followed when establishing field installation policy and procedures covering the management of NASA aircraft operations. Each operating location will develop appropriate local procedures that conform with the requirements of this handbook. This manual should be used in conjunction with other governing instructions, handbooks, and manuals.

  5. Changes of the MHC - Ⅱ and Col - Ⅰ , Col - Ⅲ in the Healing Process of Acute Skeletal Muscle Injury of Rats%大鼠骨骼肌急性拉伤修复过程中MHC-Ⅱ和COL -Ⅰ、COL -Ⅲ变化的研究

    Institute of Scientific and Technical Information of China (English)

    廖远朋

    2011-01-01

    目的:通过研究大鼠骨骼肌急性拉伤修复过程中MHC -Ⅱ和COL-Ⅰ、COL -Ⅲ的变化,了解拉伤愈合过程中肌纤维再生过程及纤维化过程.方法:将56只SD大鼠分为对照组、即刻组、第1、2、3、4、5周组,造成腓肠肌急性拉伤模型后对各组进行取材并检测MHC -Ⅱ和COL-Ⅰ、COL -Ⅲ.结果:MHC-Ⅱ水平第1周降到最低,第2周开始增加,第3周恢复正常;Col-Ⅰ水平第1周降到最低,随后逐渐增加,在第3周超过正常,持续到第5周;Col-Ⅲ从第1周开始上升,第3周达到峰值,随后逐渐下降.结论:骨骼肌急性拉伤后,骨骼肌的再生过程约在损伤l周后开始,伤后3周达到高峰,并持续5周以上.纤维化过程在损伤后1周以内开始,并持续到5周以后.其中Col-Ⅲ的水平恢复早;Col-Ⅰ的恢复较晚,但在高水平维持时间更长.

  6. Is the COL5A1 rs12722 gene polymorphism associated with running economy?

    Directory of Open Access Journals (Sweden)

    Rômulo Bertuzzi

    Full Text Available The COL5A1 rs12722 polymorphism is considered to be a novel genetic marker for endurance running performance. It has been postulated that COL5A1 rs12722 may influence the elasticity of tendons and the energetic cost of running. To date, there are no experimental data in the literature supporting the relationship between range of motion, running economy, and the COL5A1 rs12722 gene polymorphism. Therefore, the main purpose of the current study was to analyze the influence of the COL5A1rs12722 polymorphism on running economy and range of motion. One hundred and fifty (n = 150 physically active young men performed the following tests: a a maximal incremental treadmill test, b two constant-speed running tests (10 km · h(-1 and 12 km · h(-1 to determine the running economy, and c a sit-and-reach test to determine the range of motion. All of the subjects were genotyped for the COL5A1 rs12722 single-nucleotide polymorphism. The genotype frequencies were TT = 27.9%, CT = 55.8%, and CC = 16.3%. There were no significant differences between COL5A1 genotypes for running economy measured at 10 km · h(-1 (p = 0.232 and 12 km · h(-1 (p = 0.259. Similarly, there were no significant differences between COL5A1 genotypes for range of motion (p = 0.337. These findings suggest that the previous relationship reported between COL5A1 rs12722 genotypes and running endurance performance might not be mediated by the energetic cost of running.

  7. COL11A1 in FAP polyps and in sporadic colorectal tumors

    Directory of Open Access Journals (Sweden)

    Iselius Lennart

    2001-10-01

    Full Text Available Abstract Background We previously reported that the α-1 chain of type 11 collagen (COL11A1, not normally expressed in the colon, was up-regulated in stromal fibroblasts in most sporadic colorectal carcinomas. Patients with germline mutations in the APC gene show, besides colonic polyposis, symptoms of stromal fibroblast involvement, which could be related to COL11A1 expression. Most colorectal carcinomas are suggested to be a result of an activated Wnt- pathway, most often involving an inactivation of the APC gene or activation of β-catenin. Methods We used normal and polyp tissue samples from one FAP patient and a set of 37 sporadic colorectal carcinomas to find out if the up-regulation of COL11A1 was associated with an active APC/β-catenin pathway. Results In this study we found a statistically significant difference in COL11A1 expression between normal tissue and adenomas from one FAP patient, and all adenomas gave evidence for an active APC/β-catenin pathway. An active Wnt pathway has been suggested to involve stromal expression of WISP-1. We found a strong correlation between WISP-1 and COL11A1 expression in sporadic carcinomas. Conclusions Our results suggest that expression of COL11A1 in colorectal tumors could be associated with the APC/β-catenin pathway in FAP and sporadic colorectal cancer.

  8. Genetic polymorphisms in COL18A1 influence the development of osteosarcoma.

    Science.gov (United States)

    Guo, Zhihao; Zhang, Tianji; Wu, Juntao; Wang, Hongwei; Liu, Xiaotan; Tian, Linqiang

    2015-01-01

    We conducted a case-control study to investigate the association of COL18A1 D104N polymorphism in the development of osteosarcoma in a Chinese population. Between May 2012 and May 2014, 141 patients with pathologically proven osteosarcoma and 341 were selected into this study. Genotyping of COL18A1 D104N was analyzed using polymerase chain reaction (PCR) coupled with restriction fragment length polymorphism (RFLP). By logistic regression analysis, we found that individuals with the NN genotype of COL18A1 D104N were significantly associated with an increased risk of osteosarcoma when compared with the DD genotype (OR=20.97, 95% CI=2.74-933.42). In dominant model, the NN+DN genotype of COL18A1 D104N had a 1.99 fold risk of osteosarcoma when compared with the DD genotype. Moreover, the NN genotype was correlated with a 20.45 fold risk of osteosarcoma when compared with the DN+DD genotype in recessive model. However, we did not find significant interaction between COL18A1 D104N polymorphism and Enneking stage, histological subtype, tumor metastasis and tumor location of patients with osteosarcoma. In conclusion, our study suggests that the homozygous DN and NN genotypes of COL18A1 D104N were associated with the risk of osteosarcoma.

  9. A Novel COL4A5 Mutation Identified in a Chinese Han Family Using Exome Sequencing

    Directory of Open Access Journals (Sweden)

    Xiaofei Xiu

    2014-01-01

    Full Text Available Alport syndrome (AS is a monogenic disease of the basement membrane (BM, resulting in progressive renal failure due to glomerulonephropathy, variable sensorineural hearing loss, and ocular anomalies. It is caused by mutations in the collagen type IV alpha-3 gene (COL4A3, the collagen type IV alpha-4 gene (COL4A4, and the collagen type IV alpha-5 gene (COL4A5, which encodes type IV collagen α3, α4, and α5 chains, respectively. To explore the disease-related gene in a four-generation Chinese Han pedigree of AS, exome sequencing was conducted on the proband, and a novel deletion mutation c.499delC (p.Pro167Glnfs*36 in the COL4A5 gene was identified. This mutation, absent in 1,000 genomes project, HapMap, dbSNP132, YH1 databases, and 100 normal controls, cosegregated with patients in the family. Neither sensorineural hearing loss nor typical COL4A5-related ocular abnormalities (dot-and-fleck retinopathy, anterior lenticonus, and the rare posterior polymorphous corneal dystrophy were present in patients of this family. The phenotypes of patients in this AS family were characterized by early onset-age and rapidly developing into end-stage renal disease (ESRD. Our discovery broadens the mutation spectrum in the COL4A5 gene associated with AS, which may also shed new light on genetic counseling for AS.

  10. Open Rotor Noise Shielding by Blended-Wing-Body Aircraft

    Science.gov (United States)

    Guo, Yueping; Czech, Michael J.; Thomas, Russell H.

    2015-01-01

    This paper presents an analysis of open rotor noise shielding by Blended Wing Body (BWB) aircraft by using model scale test data acquired in the Boeing Low Speed Aeroacoustic Facility (LSAF) with a legacy F7/A7 rotor model and a simplified BWB platform. The objective of the analysis is the understanding of the shielding features of the BWB and the method of application of the shielding data for noise studies of BWB aircraft with open rotor propulsion. By studying the directivity patterns of individual tones, it is shown that though the tonal energy distribution and the spectral content of the wind tunnel test model, and thus its total noise, may differ from those of more advanced rotor designs, the individual tones follow directivity patterns that characterize far field radiations of modern open rotors, ensuring the validity of the use of this shielding data. Thus, open rotor tonal noise shielding should be categorized into front rotor tones, aft rotor tones and interaction tones, not only because of the different directivities of the three groups of tones, but also due to the differences in their source locations and coherence features, which make the respective shielding characteristics of the three groups of tones distinctly different from each other. To reveal the parametric trends of the BWB shielding effects, results are presented with variations in frequency, far field emission angle, rotor operational condition, engine installation geometry, and local airframe features. These results prepare the way for the development of parametric models for the shielding effects in prediction tools.

  11. Design, analysis, and control of large transport aircraft utilizing engine thrust as a backup system for the primary flight controls

    Science.gov (United States)

    Gerren, Donna S.

    1993-01-01

    A review of accidents that involved the loss of hydraulic flight control systems serves as an introduction to this project. In each of the accidents--involving transport aircraft such as the DC-10, the C-5A, the L-1011, and the Boeing 747--the flight crew attempted to control the aircraft by means of thrust control. Although these incidents had tragic endings, in the absence of control power due to primary control system failure, control power generated by selective application of engine thrust has proven to be a viable alternative. NASA Dryden has demonstrated the feasibility of controlling an aircraft during level flight, approach, and landing conditions using an augmented throttles-only control system. This system has been successfully flown in the flight test simulator for the B-720 passenger transport and the F-15 air superiority fighter and in actual flight tests for the F-15 aircraft. The Douglas Aircraft Company is developing a similar system for the MD-11 aircraft. The project's ultimate goal is to provide data for the development of thrust control systems for mega-transports (600+ passengers).

  12. Simulation and Flight Evaluation of a Parameter Estimation Input Design Method for Hybrid-Wing-Body Aircraft

    Science.gov (United States)

    Taylor, Brian R.; Ratnayake, Nalin A.

    2010-01-01

    As part of an effort to improve emissions, noise, and performance of next generation aircraft, it is expected that future aircraft will make use of distributed, multi-objective control effectors in a closed-loop flight control system. Correlation challenges associated with parameter estimation will arise with this expected aircraft configuration. Research presented in this paper focuses on addressing the correlation problem with an appropriate input design technique and validating this technique through simulation and flight test of the X-48B aircraft. The X-48B aircraft is an 8.5 percent-scale hybrid wing body aircraft demonstrator designed by The Boeing Company (Chicago, Illinois, USA), built by Cranfield Aerospace Limited (Cranfield, Bedford, United Kingdom) and flight tested at the National Aeronautics and Space Administration Dryden Flight Research Center (Edwards, California, USA). Based on data from flight test maneuvers performed at Dryden Flight Research Center, aerodynamic parameter estimation was performed using linear regression and output error techniques. An input design technique that uses temporal separation for de-correlation of control surfaces is proposed, and simulation and flight test results are compared with the aerodynamic database. This paper will present a method to determine individual control surface aerodynamic derivatives.

  13. Predicting Visibility of Aircraft

    Science.gov (United States)

    Watson, Andrew; Ramirez, Cesar V.; Salud, Ellen

    2009-01-01

    Visual detection of aircraft by human observers is an important element of aviation safety. To assess and ensure safety, it would be useful to be able to be able to predict the visibility, to a human observer, of an aircraft of specified size, shape, distance, and coloration. Examples include assuring safe separation among aircraft and between aircraft and unmanned vehicles, design of airport control towers, and efforts to enhance or suppress the visibility of military and rescue vehicles. We have recently developed a simple metric of pattern visibility, the Spatial Standard Observer (SSO). In this report we examine whether the SSO can predict visibility of simulated aircraft images. We constructed a set of aircraft images from three-dimensional computer graphic models, and measured the luminance contrast threshold for each image from three human observers. The data were well predicted by the SSO. Finally, we show how to use the SSO to predict visibility range for aircraft of arbitrary size, shape, distance, and coloration. PMID:19462007

  14. Optimizing Unmanned Aircraft System Scheduling

    Science.gov (United States)

    2008-06-01

    COL_MISSION_NAME)) If Trim( CStr (rMissions(iRow, COL_MISSION_REQUIRED))) <> "" Then If CLng(rMissions(iRow, COL_MISSION_REQUIRED)) > CLng...logFN, "s:" & CStr (s) & " " For iRow = 1 To top Print #logFN, stack(iRow) & "," Next iRow Print #logFN...340" 60 Print #logFN, "m:" & CStr (s) & " " For iRow = 1 To top Print #logFN, lMissionPeriod(iRow

  15. Tropospheric sampling with aircraft

    Energy Technology Data Exchange (ETDEWEB)

    Daum, P.H.; Springston, S.R.

    1991-03-01

    Aircraft constitute a unique environment which places stringent requirements on the instruments used to measure the concentrations of atmospheric trace gases and aerosols. Some of these requirements such as minimization of size, weight, and power consumption are general; others are specific to individual techniques. This review presents the basic principles and considerations governing the deployment of trace gas and aerosol instrumentation on an aircraft. An overview of common instruments illustrates these points and provides guidelines for designing and using instruments on aircraft-based measurement programs.

  16. Lightning hazards to aircraft

    Science.gov (United States)

    Corn, P. B.

    1978-01-01

    Lightning hazards and, more generally, aircraft static electricity are discussed by a representative for the Air Force Flight Dynamics Laboratory. An overview of these atmospheric electricity hazards to aircraft and their systems is presented with emphasis on electrical and electronic subsystems. The discussion includes reviewing some of the characteristics of lightning and static electrification, trends in weather and lightning-related mishaps, some specific threat mechanisms and susceptible aircraft subsystems and some of the present technology gaps. A roadmap (flow chart) is presented to show the direction needed to address these problems.

  17. SOLAR AIRCRAFT DESIGN

    OpenAIRE

    RAHMATI, Sadegh; GHASED, Amir

    2015-01-01

    Abstract. Generally domain Aircraft uses conventional fuel. These fuel having limited life, high cost and pollutant. Also nowadays price of petrol and other fuels are going to be higher, because of scarcity of those fuels. So there is great demand of use of non-exhaustible unlimited source of energy like solar energy. Solar aircraft is one of the ways to utilize solar energy. Solar aircraft uses solar panel to collect the solar radiation for immediate use but it also store the remaining part ...

  18. Scoliosis in osteogenesis imperfecta caused by COL1A1/COL1A2 mutations - genotype-phenotype correlations and effect of bisphosphonate treatment.

    Science.gov (United States)

    Sato, Atsuko; Ouellet, Jean; Muneta, Takeshi; Glorieux, Francis H; Rauch, Frank

    2016-05-01

    Bisphosphonates are widely used to treat children with osteogenesis imperfecta (OI), a bone fragility disorder that is most often caused by mutations in COL1A1 or COL1A2. However, it is unclear whether this treatment decreases the risk of developing scoliosis. We retrospectively evaluated spine radiographs and charts of 437 patients (227 female) with OI caused by mutations in COL1A1 or COL1A2 and compared the relationship between scoliosis, genotype and bisphosphonate treatment history. At the last follow-up (mean age 11.9 [SD: 5.9] years), 242 (55%) patients had scoliosis. The prevalence of scoliosis was highest in OI type III (89%), followed by OI type IV (61%) and OI type I (36%). Moderate to severe scoliosis (Cobb angle ≥25°) was rare in individuals with COL1A1 haploinsufficiency mutations but was present in about two fifth of patients with triple helical glycine substitutions or C-propeptide mutations. During the first 2 to 4years of bisphosphonate therapy, patients with OI type III had lower Cobb angle progression rates than before bisphosphonate treatment, whereas in OI types I and IV bisphosphonate treatment was not associated with a change in Cobb angle progression rates. At skeletal maturity, the prevalence of scoliosis (Cobb angle >10°) was similar in patients who had started bisphosphonate treatment early in life (before 5.0years of age) and in patients who had started therapy later (after the age of 10.0years) or had never received bisphosphonate therapy. Bisphosphonate treatment decreased progression rate of scoliosis in OI type III but there was no evidence of a positive effect on scoliosis in OI types I and IV. The prevalence of scoliosis at maturity was not influenced by the bisphosphonate treatment history in any OI type.

  19. Market Dominance, Efficiency, Innovation, and Globalization: A Case Study of the Tanker Competition Between Boeing and Northrop Grumman/EADS

    Science.gov (United States)

    2008-04-23

    corporate practices in the post- Enron world, to more up-to- date and open government procurement practices. These trends have resulted in the coalescence of...tankers from Boeing for $23.5 billion following a Pentagon procurement scandal , in which one of the key Air Force procurement officials, Darleen Druyen...and the CFO of Boeing, Michael Sears, went to jail. The scandal was brought to light partially with the assistance of Senator McCain’s office (Wolf

  20. Plan, formulate, discuss and correlate a NASTRAN finite element vibrations model of the Boeing Model 360 helicopter airframe

    Science.gov (United States)

    Gabel, R.; Lang, P. F.; Smith, L. A.; Reed, D. A.

    1989-01-01

    Boeing Helicopter, together with other United States helicopter manufacturers, participated in a finite element applications program to emplace in the United States a superior capability to utilize finite element analysis models in support of helicopter airframe design. The activities relating to planning and creating a finite element vibrations model of the Boeing Model 36-0 composite airframe are summarized, along with the subsequent analytical correlation with ground shake test data.

  1. Two different forms of lethal chondrodysplasias caused by COL2A1 gene mutations

    Energy Technology Data Exchange (ETDEWEB)

    Winterpacht, A.; Hilbert, K.; Schwarze, U. [Univ. of Mainz (Germany)] [and others

    1994-09-01

    Two bone dysplasia families seem to be due to mutations in the type II procollagen gene (COL2A1): the so-called spondyloepiphyseal dysplasia congenita (SEDC) group with achondrogenesis II, hypochondrogenesis, SEDC, osteoarthrosis and the Stickler-Kniest pattern that include different forms of Kniest and Stickler dysplasia. Both groups comprise a clinical spectrum ranging from lethal to mild. COL2A1-mutations have been identified in lethal forms of the SEDC family but not in lethal forms of the Stickler/Kniest group. We now report a COL2A-1 mutation in an additional case of hypochondrogenesis (patient S) and in a lethal case of Kniest dysplasia (patient B). We amplified all 54 exons of the COL2A1 gene in both patients and screened the PCR products for mutations by SSCP analysis and sequencing. In patient B, we identified an 18 bp deletion in exon 34 which removes 6 amino acids from the mature protein. In patient S, we were able to identify a two base pair exchange (GG to AT) in exon 31, which leads to the very unusual conversion of Gly to Ile. To our knowledge, this is the first report of a Gly to Ile conversion in the COL2A1 gene, and the first report of a COL2A1 gene mutation in a lethal form of Kniest dysplasia. On the basis of the known COL2A1 gene mutations and the genotype-phenotype correlations established so far, we provide molecular data (an in frame deletion in patient B and a Gly conversion in patient S) that support their clinical classification as Kniest dysplasia and hypochondrogenesis, respectively.

  2. Depreciation of aircraft

    Science.gov (United States)

    Warner, Edward P

    1922-01-01

    There is a widespread, and quite erroneous, impression to the effect that aircraft are essentially fragile and deteriorate with great rapidity when in service, so that the depreciation charges to be allowed on commercial or private operation are necessarily high.

  3. Essentials of aircraft armaments

    CERN Document Server

    Kaushik, Mrinal

    2017-01-01

    This book aims to provide a complete exposure about armaments from their design to launch from the combat aircraft. The book details modern ammunition and their tactical roles in warfare. The proposed book discusses aerodynamics, propulsion, structural as well as navigation, control, and guidance of aircraft armament. It also introduces the various types of ammunition developed by different countries and their changing trends. The book imparts knowledge in the field of design, and development of aircraft armaments to aerospace engineers and covers the role of the United Nations in peacekeeping and disarmament. The book will be very useful to researchers, students, and professionals working in design and manufacturing of aircraft armaments. The book will also serve air force and naval aspirants, and those interested in working on defence research and developments organizations. .

  4. Solar thermal aircraft

    Science.gov (United States)

    Bennett, Charles L.

    2007-09-18

    A solar thermal powered aircraft powered by heat energy from the sun. A heat engine, such as a Stirling engine, is carried by the aircraft body for producing power for a propulsion mechanism, such as a propeller. The heat engine has a thermal battery in thermal contact with it so that heat is supplied from the thermal battery. A solar concentrator, such as reflective parabolic trough, is movably connected to an optically transparent section of the aircraft body for receiving and concentrating solar energy from within the aircraft. Concentrated solar energy is collected by a heat collection and transport conduit, and heat transported to the thermal battery. A solar tracker includes a heliostat for determining optimal alignment with the sun, and a drive motor actuating the solar concentrator into optimal alignment with the sun based on a determination by the heliostat.

  5. Aircraft electromagnetic compatibility

    Science.gov (United States)

    Clarke, Clifton A.; Larsen, William E.

    1987-06-01

    Illustrated are aircraft architecture, electromagnetic interference environments, electromagnetic compatibility protection techniques, program specifications, tasks, and verification and validation procedures. The environment of 400 Hz power, electrical transients, and radio frequency fields are portrayed and related to thresholds of avionics electronics. Five layers of protection for avionics are defined. Recognition is given to some present day electromagnetic compatibility weaknesses and issues which serve to reemphasize the importance of EMC verification of equipment and parts, and their ultimate EMC validation on the aircraft. Proven standards of grounding, bonding, shielding, wiring, and packaging are laid out to help provide a foundation for a comprehensive approach to successful future aircraft design and an understanding of cost effective EMC in an aircraft setting.

  6. Aircraft Fire Protection Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — The Navy Aircraft Protection Laboratory provides complete test support for all Navy air vehicle fire protection systems.The facility allows for the simulation of a...

  7. Aircraft Fire Protection Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — The Navy Aircraft Protection Laboratory provides complete test support for all Navy air vehicle fire protection systems. The facility allows for the simulation of a...

  8. Position of glycine substitutions in the triple helix of COL6A1, COL6A2, and COL6A3 is correlated with severity and mode of inheritance in collagen VI myopathies.

    Science.gov (United States)

    Butterfield, Russell J; Foley, A Reghan; Dastgir, Jahannaz; Asman, Stephanie; Dunn, Diane M; Zou, Yaqun; Hu, Ying; Donkervoort, Sandra; Flanigan, Kevin M; Swoboda, Kathryn J; Winder, Thomas L; Weiss, Robert B; Bönnemann, Carsten G

    2013-11-01

    Glycine substitutions in the conserved Gly-X-Y motif in the triple helical (TH) domain of collagen VI are the most commonly identified mutations in the collagen VI myopathies including Ullrich congenital muscular dystrophy, Bethlem myopathy, and intermediate (INT) phenotypes. We describe clinical and genetic characteristics of 97 individuals with glycine substitutions in the TH domain of COL6A1, COL6A2, or COL6A3 and add a review of 97 published cases, for a total of 194 cases. Clinical findings include severe, INT, and mild phenotypes even from patients with identical mutations. INT phenotypes were most common, accounting for almost half of patients, emphasizing the importance of INT phenotypes to the overall phenotypic spectrum. Glycine substitutions in the TH domain are heavily clustered in a short segment N-terminal to the 17th Gly-X-Y triplet, where they are acting as dominants. The most severe cases are clustered in an even smaller region including Gly-X-Y triplets 10-15, accounting for only 5% of the TH domain. Our findings suggest that clustering of glycine substitutions in the N-terminal region of collagen VI is not based on features of the primary sequence. We hypothesize that this region may represent a functional domain within the triple helix.

  9. Safety assessment of a nuclear power plant building subjected to an aircraft crash

    Energy Technology Data Exchange (ETDEWEB)

    Thai, Duc-Kien; Kim, Seung-Eock, E-mail: sekim@sejong.ac.kr

    2015-11-15

    Highlights: • Numerical analysis of a nuclear auxiliary building under aircraft crash is conducted. • The analysis result of impact force is verified using the Riera function. • The safety assessment is performed with regard to different impact scenarios. • Discussions and conclusions on safety of the nuclear building are presented. - Abstract: This paper presents a safety assessment of a nuclear building subjected to an aircraft crash using numerical analysis. For impact simulation, the reinforced concrete (RC) Primary Auxiliary Building (PAB) of the Korea Standard Nuclear Power Plant (KSNP) is fully modeled and an aircraft model of a Boeing 767-400 is used. The Riera function is used to verify the analysis result of impact force–time history. The IRIS test is used to verify the structural behavior of the RC wall under impact loading. The safety assessment of the building is performed with regard to different impact scenarios. The safety of the nuclear building under aircraft crash, including (1) global structural safety, (2) local structural safety, and (3) vibration safety are evaluated and discussed. The results show that the global and local structural safety of the PAB is ensured in all impact scenarios. However, the vibration safety of the building is not ensured. In accordance, the regulatory guide of United States Nuclear Regulatory Commission (U.S. NRC), shutdown of the nuclear power plant is required.

  10. Automatic aircraft recognition

    Science.gov (United States)

    Hmam, Hatem; Kim, Jijoong

    2002-08-01

    Automatic aircraft recognition is very complex because of clutter, shadows, clouds, self-occlusion and degraded imaging conditions. This paper presents an aircraft recognition system, which assumes from the start that the image is possibly degraded, and implements a number of strategies to overcome edge fragmentation and distortion. The current vision system employs a bottom up approach, where recognition begins by locating image primitives (e.g., lines and corners), which are then combined in an incremental fashion into larger sets of line groupings using knowledge about aircraft, as viewed from a generic viewpoint. Knowledge about aircraft is represented in the form of whole/part shape description and the connectedness property, and is embedded in production rules, which primarily aim at finding instances of the aircraft parts in the image and checking the connectedness property between the parts. Once a match is found, a confidence score is assigned and as evidence in support of an aircraft interpretation is accumulated, the score is increased proportionally. Finally a selection of the resulting image interpretations with the highest scores, is subjected to competition tests, and only non-ambiguous interpretations are allowed to survive. Experimental results demonstrating the effectiveness of the current recognition system are given.

  11. Further Evolution of Composite Doubler Aircraft Repairs Through a Focus on Niche Applications

    Energy Technology Data Exchange (ETDEWEB)

    ROACH,DENNIS P.

    2000-07-15

    The number of commercial airframes exceeding twenty years of service continues to grow. A typical aircraft can experience over 2,000 fatigue cycles (cabin pressurizations) and even greater flight hours in a single year. An unavoidable by-product of aircraft use is that crack and corrosion flaws develop throughout the aircraft's skin and substructure elements. Economic barriers to the purchase of new aircraft have created an aging aircraft fleet and placed even greater demands on efficient and safe repair methods. The use of bonded composite doublers offers the airframe manufacturers and aircraft maintenance facilities a cost effective method to safety extend the lives of their aircraft. Instead of riveting multiple steel or aluminum plates to facilitate an aircraft repair, it is now possible to bond a single Boron-Epoxy composite doubler to the damaged structure. The FAA's Airworthiness Assurance Center at Sandia National Labs (AANC) is conducting a program with Boeing and Federal Express to validate and introduce composite doubler repair technology to the US commercial aircraft industry. This project focuses on repair of DC-10 structure and builds on the foundation of the successful L-1011 door corner repair that was completed by the AANC, Lockheed-Martin, and Delta Air Lines. The L-1011 composite doubler repair was installed in 1997 and has not developed any flaws in over three years of service, As a follow-on effort, this DC-1O repair program investigated design, analysis, performance (durability, flaw containment, reliability), installation, and nondestructive inspection issues. Current activities are demonstrating regular use of composite doubler repairs on commercial aircraft. The primary goal of this program is to move the technology into niche applications and to streamline the design-to-installation process. Using the data accumulated to date, the team has designed, analyzed, and developed inspection techniques for an array of composite doubler

  12. A COL11A2 mutation in Labrador retrievers with mild disproportionate dwarfism.

    Directory of Open Access Journals (Sweden)

    Mirjam Frischknecht

    Full Text Available We describe a mild form of disproportionate dwarfism in Labrador Retrievers, which is not associated with any obvious health problems such as secondary arthrosis. We designate this phenotype as skeletal dysplasia 2 (SD2. It is inherited as a monogenic autosomal recessive trait with incomplete penetrance primarily in working lines of the Labrador Retriever breed. Using 23 cases and 37 controls we mapped the causative mutation by genome-wide association and homozygosity mapping to a 4.44 Mb interval on chromosome 12. We re-sequenced the genome of one affected dog at 30x coverage and detected 92 non-synonymous variants in the critical interval. Only two of these variants, located in the lymphotoxin A (LTA and collagen alpha-2(XI chain gene (COL11A2, respectively, were perfectly associated with the trait. Previously described COL11A2 variants in humans or mice lead to skeletal dysplasias and/or deafness. The dog variant associated with disproportionate dwarfism, COL11A2:c.143G>C or p.R48P, probably has only a minor effect on collagen XI function, which might explain the comparatively mild phenotype seen in our study. The identification of this candidate causative mutation thus widens the known phenotypic spectrum of COL11A2 mutations. We speculate that non-pathogenic COL11A2 variants might even contribute to the heritable variation in height.

  13. COL Application Content Guide for HTGRs: Revision to RG 1.206, Part 1 - Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Wayne Moe

    2012-08-01

    A combined license (COL) application is required by the Nuclear Regulatory Commission (NRC) for all proposed nuclear plants. The information requirements for a COL application are set forth in 10 CFR 52.79, “Contents of Applications; Technical Information in Final Safety Analysis Report.” An applicant for a modular high temperature gas-cooled reactor (HTGR) must develop and submit for NRC review and approval a COL application which conforms to these requirements. The technical information necessary to allow NRC staff to evaluate a COL application and resolve all safety issues related to a proposed nuclear plant is detailed and comprehensive. To this, Regulatory Guide (RG) 1.206, “Combined License Applications for Nuclear Power Plants” (LWR Edition), was developed to assist light water reactor (LWR) applicants in incorporating and effectively formatting required information for COL application review (Ref. 1). However, the guidance prescribed in RG 1.206 presumes a LWR design proposal consistent with the systems and functions associated with large LWR power plants currently operating under NRC license.

  14. Case of Small Vessel Disease Associated with COL4A1 Mutations following Trauma

    Directory of Open Access Journals (Sweden)

    Joao McONeil Plancher

    2015-06-01

    Full Text Available With this case report, we would like to heighten the awareness of clinicians about COL4A1 as a single-gene disorder causing cerebral small vessel disease and describe a previously unreported pathogenic missense substitution in COL4A1 (p.Gly990Val and a new clinical presentation. We identified a heterozygous putatively pathogenic mutation of COL4A1 in a 50-year-old female with a history of congenital cataracts and glaucoma who presented with multiple diffusion-positive infarcts and areas of contrast enhancement following mild head trauma. We believe that this presentation of multiple areas of acute brain and vascular injury in the setting of mild head trauma is a new manifestation of this genetic disorder. Imaging findings of multiple acute infarcts and regions of contrast enhancement with associated asymptomatic old deep microhemorrhages and leukomalacia in adults after head trauma should raise a high suspicion for a COL4A1 genetic disorder. Radiographic patterns of significant leukoaraiosis and deep microhemorrhages can also be seen in patients with long-standing vasculopathy associated with hypertension, which our patient lacked. Our findings demonstrate the utility of genetic screening for COL4A1 mutations in young patients who have small vessel vasculopathy on brain imaging but who do not have significant cardiovascular risk factors.

  15. Análises dos efeitos do colágeno bovino e derivados na proliferação celular e biossíntese de colágeno em fibroblastos humanos.

    OpenAIRE

    Vergimari Rodrigues

    2009-01-01

    O colágeno é a proteína fibrosa predominante da matriz extracelular e é a maior proteína constituinte do tecido conectivo. Alterações nas taxas de colágeno tipo I na derme ocorrem durante o envelhecimento. A introdução de um agente eficaz para a manutenção da pele durante o envelhecimento é importante, possibilitando a redução destes efeitos. Neste projeto foram avaliados os efeitos proliferativos e de biossíntese de colágeno, em fibroblastos humanos de derme normal tratados com colágeno bovi...

  16. An Operational Hygiene Study for Ozone in the Cabin of the Canadian Forces (CC137) Boeing 707 Aircraft,

    Science.gov (United States)

    1982-08-01

    Biological Effects At high concentrations, ozone is a bluish gas with a characteristic pungent odour, often described as "smelling like" new mown...a sensation of irritation to the eyes within 6 minutes at a concentration of 2 - 3.7 ppm. Chronical- ly, 03 has been reported to result in bronchioli

  17. 78 FR 68985 - Special Conditions: Boeing Model 777-200, -300, and -300ER Series Airplanes; Aircraft Electronic...

    Science.gov (United States)

    2013-11-18

    ... and connectivity of the passenger service computer network systems to the airplane critical systems... perform functions required for the safe operation of the airplane. This proposed data network and design... computer network system, and a network extension device. The network extension device will improve...

  18. 78 FR 68986 - Special Conditions: Boeing Model 777-200, -300, and -300ER Series Airplanes; Aircraft Electronic...

    Science.gov (United States)

    2013-11-18

    ... following novel or unusual design features: An onboard computer network system, and a network extension... and connectivity capabilities of the airplane's onboard network computer systems, which may allow access to or by external computer systems and networks. This onboard network system will be composed of...

  19. 波音飞机OIL CANNING损伤研究%Research on Oil Canning Damage of Boeing Aircraft

    Institute of Scientific and Technical Information of China (English)

    郭跃军

    2014-01-01

    根据对波音飞机Oil Canning损伤处理的经验,并参考波音手册和相关文献资料的说明,对波音飞机Oil Canning损伤的成因、特征和修理进行深入研究,旨在使业界同行能够准确判断此损伤并采取正确合理的处理措施,保障航空安全,提高维修效率。

  20. 75 FR 3250 - The Boeing Company Commercial Aircraft Group, Including On-Site Leased Workers From Comforce...

    Science.gov (United States)

    2010-01-20

    ... Workers From Comforce Corporation, Adecco, Multax, Inconen, CTS, Hi-Tec, Woods, Ciber, Kelly Services... On-Site Leased Workers From Comforce Corporation, Adecco, Multax, Inconen, CTS, Hi-Tec, Woods, Ciber..., Adecco, Multax, Inconen, CTS, Hi-Tec, Woods, Ciber, Kelly Services, Analysts International Corp,...

  1. Immunological characterization of recombinantWuchereria bancrofti cuticular collagen (COL-4) as putative vaccine candidate for human lymphatic filariasis

    Institute of Scientific and Technical Information of China (English)

    Chakkaravarthy Arunkumar; Pandurangan Pandiaraja; P. R. Prince; Perumal Kaliraj

    2014-01-01

    Objective:To elucidate immunoprophylactic potential of recombinantWuchereria bancrofti(W. bancrofti) cuticular collagen(COL-4) inBALB/c mice and filarial clinical samples.Methods:col-4 gene wasPCR amplified fromW. bancroftiL3 cDNA library and cloned in pRSETB vector. RecombinantCOL-4 was over expressed in salt inducible system and was purified by nickel affinity chromatography.Humoral and cellular responses were measured byELISA and peripheral blood mononuclear cells(PBMC) of various filarial clinical samples respectively using purified recombinantCOL-4 antigen.Then the protective immune responses ofCOL-4 immunizedBALB/c mice were characterized.Results:Sequence analysis ofCOL-4 with human host proteins reveals lack of homology.The recombinantCOL-4 was found to be at15 kDa fusion protein.The affinity purifiedCOL-4 showed significant reactivity with putatively immune sera and in a similar fashion it demonstrated marked proliferation inPBMC samples.Immunization studies in experimental filarial host(mice) elicited significant titers with protective antibody isotype profile(IgM and IgG).Cellular immune responses were also significant in terms of splenocytes proliferation assay on mice samples.Conclusions:Our immunological findings in experimental host suggestTh2 mediated immune response.Hence, we propose thatW. bancroftiCOL-4 could be an efficacious vaccine candidate against lymphatic filariasis.

  2. Integration of structural health monitoring solutions onto commercial aircraft via the Federal Aviation Administration structural health monitoring research program

    Science.gov (United States)

    Swindell, Paul; Doyle, Jon; Roach, Dennis

    2017-02-01

    The Federal Aviation Administration (FAA) started a research program in structural health monitoring (SHM) in 2011. The program's goal was to understand the technical gaps of implementing SHM on commercial aircraft and the potential effects on FAA regulations and guidance. The program evolved into a demonstration program consisting of a team from Sandia National Labs Airworthiness Assurance NDI Center (AANC), the Boeing Corporation, Delta Air Lines, Structural Monitoring Systems (SMS), Anodyne Electronics Manufacturing Corp (AEM) and the FAA. This paper will discuss the program from the selection of the inspection problem, the SHM system (Comparative Vacuum Monitoring-CVM) that was selected as the inspection solution and the testing completed to provide sufficient data to gain the first approved use of an SHM system for routine maintenance on commercial US aircraft.

  3. Salapärane Boeing tõi Eestisse konteinereid / Ester Vilgats

    Index Scriptorium Estoniae

    Vilgats, Ester

    2005-01-01

    Ilmunud ka: Pärnu Postimees 8. nov., lk. 3, Postimees : na russkom jazõke 10. nov. lk. 10. Pärnu lennujaama juhataja Erki Teemägi ja Kaitsepolitsei Pärnu osakonna politseidirektor Kalev Kont kinnitasid, et Pärnu lennuväljal 12. jaanuaril 2003. aastal maandunud Boeing 737 vedas kaubakonteinereid, mitte terroristidest sõjavange, nagu väitis ajaleht Washington Post. Vt. samas: Neeme Raud. Inimõiguslased ootavad euroliidu sekkumist

  4. Management strategies in the aerospace industry. Particular case: The Boeing Company

    Directory of Open Access Journals (Sweden)

    Daniela MOCENCO

    2015-03-01

    Full Text Available The present paper aims to provide an overview of the aviation industry in the United States (US. The study focuses on Boeing Company analyzing the organizational architecture and management strategies applied throughout its evolution. The paper is structured in three parts: the first part presents the scientific references; part two focuses on the structure, management strategies and performances of the company; the last part is devoted to conclusions

  5. Management strategies in the aerospace industry. Particular case: The Boeing Company

    OpenAIRE

    Daniela MOCENCO

    2015-01-01

    The present paper aims to provide an overview of the aviation industry in the United States (US). The study focuses on Boeing Company analyzing the organizational architecture and management strategies applied throughout its evolution. The paper is structured in three parts: the first part presents the scientific references; part two focuses on the structure, management strategies and performances of the company; the last part is devoted to conclusions

  6. A novel COL11A1 missense mutation in siblings with non-ocular Stickler syndrome.

    Science.gov (United States)

    Kohmoto, Tomohiro; Tsuji, Atsumi; Morita, Kei-Ichi; Naruto, Takuya; Masuda, Kiyoshi; Kashimada, Kenichi; Enomoto, Keisuke; Morio, Tomohiro; Harada, Hiroyuki; Imoto, Issei

    2016-01-01

    Stickler syndrome (STL) is an autosomal, dominantly inherited, clinically variable and genetically heterogeneous connective tissue disorder characterized by ocular, auditory, orofacial and skeletal abnormalities. We conducted targeted resequencing using a next-generation sequencer for molecular diagnosis of a 2-year-old girl who was clinically suspected of having STL with Pierre Robin sequence. We detected a novel heterozygous missense mutation, NM_001854.3:n.4838G>A [NM_001854.3 (COL11A1_v001):c.4520G>A], in COL11A1, resulting in a Gly to Asp substitution at position 1507 [NM_001854.3(COL11A1_i001)] within one of the collagen-like domains of the triple helical region. The same mutation was detected in her 4-year-old brother with cleft palate and high-frequency sensorineural hearing loss.

  7. A 6.4 hr positive superhump period in TV Col

    CERN Document Server

    Retter, A

    1999-01-01

    Re-examination of photometric data of TV Col (Hellier, 1993) reveals positive superhumps in addition to the negative superhumps previously known. The superhump period is 0.265+/-0.005 day - about 16 percent longer than the orbital period - which obeys the relation between superhump-period excess and orbital period (Stolz and Schoembs 1984). As a confirmed permanent superhumper, the accretion disc of TV Col is naturally thermally stable. Therefore, our result supports the idea of Hellier and Buckley (1993) that the short-term outbursts seen in its light curve are mass transfer events rather than thermal instabilities in the disc. At 5.5-hr, TV Col has a longer orbital period than any known superhumper, and thus a mass ratio which is probably outside the range at which superhumps can occur according to current theory.

  8. Using binary optical elements (BOEs) to generate rectangular spots for illumination in micro flow cytometer

    Science.gov (United States)

    Zhao, Jingjing; You, Zheng

    2016-01-01

    This work introduces three rectangular quasi-flat-top spots, which are provided by binary optical elements (BOEs) and utilized for the illumination in a microflow cytometer. The three spots contain, respectively, one, two, and three rectangles (R1, R2, and R3). To test the performance of this mechanism, a microflow cytometer is established by integrating the BOEs and a three-dimensional hydrodynamic focusing chip. Through the experiments of detecting fluorescence microbeads, the three spots present good fluorescence coefficients of variation in comparison with those derived from commercial instruments. Benefiting from a high spatial resolution, when using R1 spot, the micro flow cytometer can perform a throughput as high as 20 000 events per second (eps). Illuminated by R2 or R3 spot, one bead emits fluorescence twice or thrice, thus the velocity can be measured in real time. Besides, the R3 spot provides a long-time exposure, which is conducive to improving fluorescence intensity and the measurement stability. In brief, using the spots shaped and homogenized by BOEs for illumination can increase the performance and the functionality of a micro flow cytometer. PMID:27733892

  9. HANAC Syndrome Col4a1 Mutation Causes Neonate Glomerular Hyperpermeability and Adult Glomerulocystic Kidney Disease.

    Science.gov (United States)

    Chen, Zhiyong; Migeon, Tiffany; Verpont, Marie-Christine; Zaidan, Mohamad; Sado, Yoshikazu; Kerjaschki, Dontscho; Ronco, Pierre; Plaisier, Emmanuelle

    2016-04-01

    Hereditary angiopathy, nephropathy, aneurysms, and muscle cramps (HANAC) syndrome is an autosomal dominant syndrome caused by mutations in COL4A1 that encodes the α1 chain of collagen IV, a major component of basement membranes. Patients present with cerebral small vessel disease, retinal tortuosity, muscle cramps, and kidney disease consisting of multiple renal cysts, chronic kidney failure, and sometimes hematuria. Mutations producing HANAC syndrome localize within the integrin binding site containing CB3[IV] fragment of the COL4A1 protein. To investigate the pathophysiology of HANAC syndrome, we generated mice harboring the Col4a1 p.Gly498Val mutation identified in a family with the syndrome. Col4a1 G498V mutation resulted in delayed glomerulogenesis and podocyte differentiation without reduction of nephron number, causing albuminuria and hematuria in newborns. The glomerular defects resolved within the first month, but glomerular cysts developed in 3-month-old mutant mice. Abnormal structure of Bowman's capsule was associated with metalloproteinase induction and activation of the glomerular parietal epithelial cells that abnormally expressed CD44,α-SMA, ILK, and DDR1. Inflammatory infiltrates were observed around glomeruli and arterioles. Homozygous Col4a1 G498V mutant mice additionally showed dysmorphic papillae and urinary concentration defects. These results reveal a developmental role for the α1α1α2 collagen IV molecule in the embryonic glomerular basement membrane, affecting podocyte differentiation. The observed association between molecular alteration of the collagenous network in Bowman's capsule of the mature kidney and activation of parietal epithelial cells, matrix remodeling, and inflammation may account for glomerular cyst development and CKD in patients with COL4A1-related disorders.

  10. Solid Oxide Fuel Cell APU Feasibility Study for a Long Range Commercial Aircraft Using UTC ITAPS Approach. Volume 1; Aircraft Propulsion and Subsystems Integration Evaluation

    Science.gov (United States)

    Srinivasan, Hari; Yamanis, Jean; Welch, Rick; Tulyani, Sonia; Hardin, Larry

    2006-01-01

    The objective of this contract effort was to define the functionality and evaluate the propulsion and power system benefits derived from a Solid Oxide Fuel Cell (SOFC) based Auxiliary Power Unit (APU) for a future long range commercial aircraft, and to define the technology gaps to enable such a system. The study employed technologies commensurate with Entry into Service (EIS) in 2015. United Technologies Corporation (UTC) Integrated Total Aircraft Power System (ITAPS) methodologies were used to evaluate system concepts to a conceptual level of fidelity. The technology benefits were captured as reductions of the mission fuel burn and emissions. The baseline aircraft considered was the Boeing 777-200ER airframe with more electric subsystems, Ultra Efficient Engine Technology (UEET) engines, and an advanced APU with ceramics for increased efficiency. In addition to the baseline architecture, four architectures using an SOFC system to replace the conventional APU were investigated. The mission fuel burn savings for Architecture-A, which has minimal system integration, is 0.16 percent. Architecture-B and Architecture-C employ greater system integration and obtain fuel burn benefits of 0.44 and 0.70 percent, respectively. Architecture-D represents the highest level of integration and obtains a benefit of 0.77 percent.

  11. COL4A1 Mutations and Cerebral Small Vessel Disease%COL4A1基因突变与脑血管病

    Institute of Scientific and Technical Information of China (English)

    陈宇

    2010-01-01

    Ⅳ型胶原蛋自基因α1(αl type IV collagen,COUA1)编码IV型胶原的αl链,是构成所有组织基底膜的主要成分.COL4A1基因突变可引起脑内小动脉病变,在一定的环境压力下引发脑内小血管的阻塞或破裂,造成脑出血(intracerrbral hemorrhage,ICH).本文综述了COL4A1与α1链的结构,构成Ⅳ型胶原的方式,Ⅳ型胶原在基底膜中的作用以及目前发现的COL4A1突变引发的人类脑血管方面的疾病,并对发病机理进行了简要综述.

  12. Noise Scaling and Community Noise Metrics for the Hybrid Wing Body Aircraft

    Science.gov (United States)

    Burley, Casey L.; Brooks, Thomas F.; Hutcheson, Florence V.; Doty, Michael J.; Lopes, Leonard V.; Nickol, Craig L.; Vicroy, Dan D.; Pope, D. Stuart

    2014-01-01

    An aircraft system noise assessment was performed for the hybrid wing body aircraft concept, known as the N2A-EXTE. This assessment is a result of an effort by NASA to explore a realistic HWB design that has the potential to substantially reduce noise and fuel burn. Under contract to NASA, Boeing designed the aircraft using practical aircraft design princip0les with incorporation of noise technologies projected to be available in the 2020 timeframe. NASA tested 5.8% scale-mode of the design in the NASA Langley 14- by 22-Foot Subsonic Tunnel to provide source noise directivity and installation effects for aircraft engine and airframe configurations. Analysis permitted direct scaling of the model-scale jet, airframe, and engine shielding effect measurements to full-scale. Use of these in combination with ANOPP predictions enabled computations of the cumulative (CUM) noise margins relative to FAA Stage 4 limits. The CUM margins were computed for a baseline N2A-EXTE configuration and for configurations with added noise reduction strategies. The strategies include reduced approach speed, over-the-rotor line and soft-vane fan technologies, vertical tail placement and orientation, and modified landing gear designs with fairings. Combining the inherent HWB engine shielding by the airframe with added noise technologies, the cumulative noise was assessed at 38.7 dB below FAA Stage 4 certification level, just 3.3 dB short of the NASA N+2 goal of 42 dB. This new result shows that the NASA N+2 goal is approachable and that significant reduction in overall aircraft noise is possible through configurations with noise reduction technologies and operational changes.

  13. A Comparison of Force-Time History Analysis Methods for Simplified Aircraft Impact Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Sangshup; Hahm, Daegi; Choi, In Kil [Korea Atomic Energy Research institute, Daejeon (Korea, Republic of)

    2013-10-15

    In this paper, by comparing the various F-T History analysis method, we are about to propose the most reliable simplified method under the same condition with M-T Interaction analysis method. To find the suitable loading area applied aircraft crash, the studies for a various loading area (Case 1, 2, 3) ware performed using F-T History analysis method, and the former results were compared to the result of Case 4 using M-T Interaction analysis method. The various results according to the proposed loading area were pointed out. Thus, the results for a simplified loading area applied impact load may be fairly sensitive to the assumption associated with loading area. Finally, we can conclude that the Case 3 shows conservative and the most similar results with realistic simulation using M-T Interaction analysis method, i. e., Case 4. The reaction force-time relationship for accidental strike of Boeing 707-320 aircraft against a rigid surface was proposed by Riera. After that, the aircraft impact analysis has been studied significantly in the last few decades. The only way to acquire an exact solution of the aircraft impact analysis is direct impact test. However, for the large commercial aircraft impact, this direct test has been hardly performed because the scale of aircraft and impacted wall is very huge. Up to date, the numerical simulation using Missile-Target (M-T) Interaction analysis method is known as the only way to obtain a relatively accurate solution. However, because of its massive computational efforts and modeling complexity, this method is inadequate and inefficient to the application of the fragility analysis and risk assessments which is required many times of iterative simulations. Thus, a more simplified and conservative analysis method is required. The simplified method such as Force-Time (F-T) History analysis method has been studied by Riera, Sugano et al., Mullapudi et al. and etc.

  14. Identification of Aircraft Hazards

    Energy Technology Data Exchange (ETDEWEB)

    K. Ashley

    2006-12-08

    Aircraft hazards were determined to be potentially applicable to a repository at Yucca Mountain in ''Monitored Geological Repository External Events Hazards Screening Analysis'' (BSC 2005 [DIRS 174235], Section 6.4.1). That determination was conservatively based upon limited knowledge of flight data in the area of concern and upon crash data for aircraft of the type flying near Yucca Mountain. The purpose of this report is to identify specific aircraft hazards that may be applicable to a monitored geologic repository (MGR) at Yucca Mountain, using NUREG-0800, ''Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants'' (NRC 1987 [DIRS 103124], Section 3.5.1.6), as guidance for the inclusion or exclusion of identified aircraft hazards. The intended use of this report is to provide inputs for further screening and analysis of identified aircraft hazards based upon the criteria that apply to Category 1 and Category 2 event sequence analyses as defined in 10 CFR 63.2 [DIRS 176544] (Section 4). The scope of this report includes the evaluation of military, private, and commercial use of airspace in the 100-mile regional setting of the repository at Yucca Mountain with the potential for reducing the regional setting to a more manageable size after consideration of applicable screening criteria (Section 7).

  15. IDENTIFICATION OF AIRCRAFT HAZARDS

    Energy Technology Data Exchange (ETDEWEB)

    K.L. Ashley

    2005-03-23

    Aircraft hazards were determined to be potentially applicable to a repository at Yucca Mountain in the ''Monitored Geological Repository External Events Hazards Screening Analysis'' (BSC 2004, Section 6.4.1). That determination was conservatively based on limited knowledge of flight data in the area of concern and on crash data for aircraft of the type flying near Yucca Mountain. The purpose of this report is to identify specific aircraft hazards that may be applicable to a Monitored Geologic Repository (MGR) at Yucca Mountain using NUREG-0800, ''Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants'' (NRC 1987, Section 3.5.1.6), as guidance for the inclusion or exclusion of identified aircraft hazards. NUREG-0800 is being used here as a reference because some of the same considerations apply. The intended use of this report is to provide inputs for further screening and analysis of the identified aircraft hazards based on the criteria that apply to Category 1 and 2 event sequence analyses as defined in 10 CFR 63.2 (see Section 4). The scope of this technical report includes the evaluation of military, private, and commercial use of airspace in the 100-mile regional setting of the MGR at Yucca Mountain with the potential for reducing the regional setting to a more manageable size after consideration of applicable screening criteria (see Section 7).

  16. Aircraft Operations Classification System

    Science.gov (United States)

    Harlow, Charles; Zhu, Weihong

    2001-01-01

    Accurate data is important in the aviation planning process. In this project we consider systems for measuring aircraft activity at airports. This would include determining the type of aircraft such as jet, helicopter, single engine, and multiengine propeller. Some of the issues involved in deploying technologies for monitoring aircraft operations are cost, reliability, and accuracy. In addition, the system must be field portable and acceptable at airports. A comparison of technologies was conducted and it was decided that an aircraft monitoring system should be based upon acoustic technology. A multimedia relational database was established for the study. The information contained in the database consists of airport information, runway information, acoustic records, photographic records, a description of the event (takeoff, landing), aircraft type, and environmental information. We extracted features from the time signal and the frequency content of the signal. A multi-layer feed-forward neural network was chosen as the classifier. Training and testing results were obtained. We were able to obtain classification results of over 90 percent for training and testing for takeoff events.

  17. Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil: Role of COL1A1

    OpenAIRE

    Almeida, Lucas; Oliveira, Joyce; Guimarães, Luiz Henrique; Carvalho, Edgar M.; Blackwell, Jenefer M.; Castellucci, Léa

    2015-01-01

    Previous studies have demonstrated a role for wound healing genes in resolution of cutaneous lesions caused by Leishmania spp. in both mice and humans, including the gene FLI1 encoding Friend leukaemia virus integration 1. Reduction of Fli1 expression in mice has been shown to result in up-regulation of collagen type I alpha 1 (Col1a1) and alpha 2 (Col1a2) genes and, conversely, in down-regulation of the matrix metalloproteinase 1 (Mmp1) gene, suggesting that Fli1 suppression is involved in a...

  18. Effects of reinforcement ratio and arrangement on the structural behavior of a nuclear building under aircraft impact

    Energy Technology Data Exchange (ETDEWEB)

    Thai, Duc-Kien; Kim, Seung-Eock, E-mail: sekim@sejong.ac.kr; Lee, Hyuk-Kee

    2014-09-15

    Highlights: • Numerical analysis of RC nuclear building model under aircraft impact was conducted. • The analysis result shows similar behavior as compared to the Riera function. • The effects of reinforcement ratio and arrangement were enumerated. • The appropriate number of layer of longitudinal rebar was recommended. - Abstract: This study presents the effectiveness of the rebar ratio and the arrangement of reinforced concrete (RC) structures on the structural behavior of nuclear buildings under aircraft impact using a finite element (FE) approach. A simplified model of a fictitious nuclear building using RC structures was fully modeled. The aircraft model of a Boeing 767-400 was used for impact simulation and was developed and verified with a conventional impact force–time history curve. The IRIS Punching test was used to validate the damage prediction capabilities of the RC wall under impact loading. With regard to the different rebar ratios and rebar arrangements of a nuclear RC building, the structural behavior of a building under aircraft impact was investigated. The structural behavior investigated included plastic deformation, displacement, energy dissipation, perforation/penetration depth and scabbing area. The results showed that the rebar ratio has a significant effect on withstanding aircraft impact and reducing local damage. With four layers of rebar, the RC wall absorbed and dissipated the impact energy more than once with only two layers of rebar for the same rebar ratio.

  19. Advanced Aircraft Material

    Directory of Open Access Journals (Sweden)

    Vivek Kumar Prince

    2013-06-01

    Full Text Available There has been long debate on “advanced aircraft material” from past decades & researchers too came out with lots of new advanced material like composites and different aluminum alloys. Now days a new advancement that is in great talk is third generation Aluminum-lithium alloy. Newest Aluminum-lithium alloys are found out to have low density, higher elastic modulus, greater stiffness, greater cryogenic toughness, high resistance to fatigue cracking and improved corrosion resistance properties over the earlier used aircraft material as mentioned in Table 3 [1-5]. Comparison had been made with nowadays used composite material and is found out to be more superior then that

  20. Aircraft Fuel Systems Career Ladder.

    Science.gov (United States)

    1985-09-01

    type fittings remove and install fuel cells clean work areas inspect aircraft for safety pin installation purge tanks or cells using blow purge method...INSPECT AIRCRAFT FOR SAFETY PIN INSTALLATION 84 H254 PURGE TANKS OR CELLS USING BLOW PURGE METHOD 83 H227 CHECK AIRCRAFT FOR LIQUID OXYGEN (LOX...H243 INSPECT AIRCRAFT FOR SAFETY PIN INSTALLATION 52 M483 MIX SEALANTS BY HAND 48 K372 CONNECT OR DISCONNECT WIGGINS TYPE FITTINGS 48 H236 DISCONNECT

  1. Entomopathogenic fungi in predatory beetles (Col: Carabidae and Staphylinidae) from agricultural fields

    DEFF Research Database (Denmark)

    Steenberg, T; Langer, V; Esbjerg, P

    1995-01-01

    Prevalence of entomopathogenic fungi was studied in overwintering ground beetles (Col.: Carabidae) and rove beetles (Col.: Staphylinidae) collected from fields of lucerne, white cabbage and white cabbage undersown with white clover. In general infection levels in adult ground beetles and rove bee...... (Zygomycetes: Entomophthorales). Two individuals of Anotylus rugosus were found to have a dual infection of Zoophthora philonthi and Beauveria bassiana...

  2. Las cuentas del cuarto viaje de Cristóbal Colón

    Directory of Open Access Journals (Sweden)

    Gil, Juan

    2003-12-01

    Full Text Available The payroll of the fourth voyage of Christopher Columbus is here published for the fisrt time, signed by Admiral himself. A commentary is also furnished.

    Se publican por primera vez, con comentario, las cuentas del cuarto viaje de Cristóbal Colón, firmadas por el propio almirante.

  3. Fibrochondrogenesis results from mutations in the COL11A1 type XI collagen gene.

    Science.gov (United States)

    Tompson, Stuart W; Bacino, Carlos A; Safina, Nicole P; Bober, Michael B; Proud, Virginia K; Funari, Tara; Wangler, Michael F; Nevarez, Lisette; Ala-Kokko, Leena; Wilcox, William R; Eyre, David R; Krakow, Deborah; Cohn, Daniel H

    2010-11-12

    Fibrochondrogenesis is a severe, autosomal-recessive, short-limbed skeletal dysplasia. In a single case of fibrochondrogenesis, whole-genome SNP genotyping identified unknown ancestral consanguinity by detecting three autozygous regions. Because of the predominantly skeletal nature of the phenotype, the 389 genes localized to the autozygous intervals were prioritized for mutation analysis by correlation of their expression with known cartilage-selective genes via the UCLA Gene Expression Tool, UGET. The gene encoding the α1 chain of type XI collagen (COL11A1) was the only cartilage-selective gene among the three candidate intervals. Sequence analysis of COL11A1 in two genetically independent fibrochondrogenesis cases demonstrated that each was a compound heterozygote for a loss-of-function mutation on one allele and a mutation predicting substitution for a conserved triple-helical glycine residue on the other. The parents who were carriers of missense mutations had myopia. Early-onset hearing loss was noted in both parents who carried a loss-of-function allele, suggesting COL11A1 as a locus for mild, dominantly inherited hearing loss. These findings identify COL11A1 as a locus for fibrochondrogenesis and indicate that there might be phenotypic manifestations among carriers.

  4. Stimulation of Escherichia coli F-18Col- Type-1 fimbriae synthesis by leuX

    DEFF Research Database (Denmark)

    Newman, Joseph V.; Burghoff, Robert L.; Pallesen, Lars

    1994-01-01

    alone but is eliminated when fed together with E. coli F-18. Recently we randomly cloned E. coli F-18 DNA into E. coli F-18Col- and let the mouse intestine select the best colonizer. In this way, we isolated a 6.5-kb E. coli F-18 DNA sequence that simultaneously stimulated synthesis of type 1 fimbriae...

  5. Phase I and pharmacokinetic study of COL-3 in patients with recurrent high-grade gliomas.

    Science.gov (United States)

    Rudek, Michelle A; New, Pamela; Mikkelsen, Tom; Phuphanich, Surasak; Alavi, Jane B; Nabors, Louis B; Piantadosi, Steven; Fisher, Joy D; Grossman, Stuart A

    2011-11-01

    COL-3 is a chemically modified tetracycline that targets multiple aspects of matrix metalloproteinase regulation. This phase I clinical trial was conducted to determine the maximum tolerated dose (MTD) of COL-3 in adults with recurrent high-grade glioma, to describe the effects of enzyme-inducing antiseizure drugs (EIADs) on its pharmacokinetics, and to obtain preliminary evidence of activity. Adults with recurrent high-grade glioma were stratified by EIAD use. COL-3 was given orally daily without interruption until disease progression or treatment-related dose-limiting toxicity (DLT). Three patients in each EIAD group were evaluated at each dose level beginning with 25 mg/m(2)/day and escalated by 25 mg/m(2)/day. Toxicity, response, and pharmacokinetics were assessed. Thirty-three patients were evaluated. The MTD was 75 mg/m(2)/day in the -EIAD patients while one was not determined in +EIAD patients. The common toxicities observed were anemia, ataxia, diarrhea, hypokalemia, CNS hemorrhage, and myalgia. One partial response was observed. -EIAD patients tended to have a higher steady-state trough concentration that was apparent only at the 100 mg/m(2)/day dose level (P = 0.01). This study suggests that: (a) EIAD use does affect the pharmacokinetics of COL-3 at higher doses; and (b) there was not enough suggestion of single-agent activity to warrant further study in recurrent high-grade gliomas.

  6. Two-step method for curing Escherichia coli of ColE1-derived plasmids

    DEFF Research Database (Denmark)

    Hove-Jensen, Bjarne

    2008-01-01

    To cure Escherichia coli for plasmids derived from the ColE1 replicon advantage is taken of the fact that maintenance of this replicon requires a wild-type allele of polA, encoding DNA polymerase I. Curing is achieved by cotransduction of a mutant polA allele with metE::Tn10, fadAB::Tn10 or other...

  7. Effects of a malfunctional column on conventional and FeedCol-simulated moving bed chromatography performance.

    Science.gov (United States)

    Song, Ji-Yeon; Oh, Donghoon; Lee, Chang-Ha

    2015-07-17

    The effects of a malfunctional column on the performance of a simulated moving bed (SMB) process were studied experimentally and theoretically. The experimental results of conventional four-zone SMB (2-2-2-2 configuration) and FeedCol operation (2-2-2-2 configuration with one feed column) with one malfunctional column were compared with simulation results of the corresponding SMB processes with a normal column configuration. The malfunctional column in SMB processes significantly deteriorated raffinate purity. However, the extract purity was equivalent or slightly improved compared with the corresponding normal SMB operation because the complete separation zone of the malfunctional column moved to a lower flow rate range in zones II and III. With the malfunctional column configuration, FeedCol operation gave better experimental performance (up to 7%) than conventional SMB operation because controlling product purity with FeedCol operation was more flexible through the use of two additional operating variables, injection time and injection length. Thus, compared with conventional SMB separation, extract with equivalent or slightly better purity could be produced from FeedCol operation even with a malfunctional column, while minimizing the decrease in raffinate purity (less than 2%).

  8. Evidence for large superhumps in TX Col and V4742 Sgr

    CERN Document Server

    Retter, A; Liu, A; Bos, Marc; Liu, Alexander; Retter, Alon

    2004-01-01

    Since the discovery of the largest positive superhump period in TV Col, we have started a program to search for superhumps in CVs with large orbital periods. Here, we summarize preliminary results of TX Col and V4742 Sgr. TX Col is an intermediate polar with a 5.7-h orbital period. V4742 Sgr is a recent nova with no known periods. CCD unfiltered continuous photometry of these 2 objects was carried out during 56 nights in 2002-3. In TX Col, in addition to the orbital period of 5.7 h, we found peaks at 7.1 h and 5.0 h. These are interpreted as positive and negative superhumps correspondingly, although the effects of the quasi-periodic oscillations at about 2 h were not taken into consideration. In the light curve of V4742 Sgr 2 long periods are detected -- 6.1 and 5.4 h as well as a short-term period at 1.6 h. This result suggests that V4742 Sgr is an intermediate polar candidate and a permanent superhump system with a large orbital period (5.4 h) and a superhump period excess of 13 percent. If these results ar...

  9. Effects of clinorotation on COL1A1- EGFP gene expression

    Institute of Scientific and Technical Information of China (English)

    DAI Zhongquan; LI Yinghui; DING Bai; ZHANG Yuguo; LIU Weiquan; LIU Pengpeng

    2004-01-01

    Bone-formation related gene plays a critical role in bone loss induced by space microgravity, however the exact mechanism is unclear. In this study, we aim to investigate the effect of microgravity on the activity of α 1(I) collagen (COL1A1) gene promoter and the expression of osteoblast-related genes. COL1A1 promoter was digested by restriction enzymes resulting in three DNA fragments. The fragments were ligated with the enhanced green fluorescent protein report gene, and subcloned into expression vectors. ROS17/2.8 cells transfected by these vectors were screened by G418, and enhanced green fluorescent protein (EGFP) positive colonies were isolated and cultured under clinostat condition. EGFP and Collagen type I expression level were detected by fluorescence intensity analysis and immunocytochemistry methods respectively. The results showed that the expression of EGFP and collagen type I was increased 24 h, 48 h after the cells were cultured under stimulated microgravity, illustrating that the activity of COL1A1 promoter might be increased. In conclusion, osteoblasts can compensatively increase the expression of type I collagen by enhancing the activity of COL1A1 promoter under short-term simulated microgravity conditions.

  10. NOVEL SPLICING MUTATION OF COL1A1 GENE CAUSING OSTEOGENESIS IMPERFECTA TYPE I IN CHINESE PEDIGREE

    Institute of Scientific and Technical Information of China (English)

    WU Xiao-lin; GU Ming-min; CUI Bing; LI Xi-hua; LU Zhen-yu; WANG Zhu-gang; YUAN Wen-tao; SONG Huai-dong

    2007-01-01

    Objective To detect the peculiar mutation in a Chinese family with osteogenesis imperfecta,COL1A1 and COL1A2 being analysed. Methods A genome screen was undertaken covering COL1A1 at 17q21-22 and COL1A2 at 7q22.1. The Linkage ( Version 5.1 ) was used for 2-point analysis. DNA sequencing was used to screen and identify the mutation. Results A linkage to the markers on chromosome 17q21-22 was observed. Sequence analysis of COL1A1 revealed a splicing mutation ( IVS8-2A > G) that converted the 3' end of intron 8 from AG to GG. Conclusion This mutation ( IVS 8-2A > G) is novel, and has not yet been registered in the Human Type Ⅰ and Type Ⅲ Collagen Mutations Database.

  11. Col-F, a fluorescent probe for ex vivo confocal imaging of collagen and elastin in animal tissues.

    Science.gov (United States)

    Biela, Ewa; Galas, Jerzy; Lee, Brian; Johnson, Gary L; Darzynkiewicz, Zbigniew; Dobrucki, Jurek W

    2013-06-01

    A new low-molecular-weight fluorescent probe, Col-F, that exhibits affinity to collagen and elastin, was used successfully in imaging of extracellular matrix in freshly excised animal tissues. Col-F readily penetrates between live cells into tissues and binds to fibers of collagen and elastin by a noncovalent mechanism. Fibers of collagen and elastin have been stained in a variety of tissues, including tendon, skeletal muscle, connective tissue, and arteries. Cells migrating in a Col-F-stained collagenous biomaterial were also imaged. No phototoxic effects were detected when live keratocytes were imaged in the in vitro culture in the presence of Col-F. In conclusion, Col-F provides a simple and convenient tool for fluorescence three-dimensional imaging of intricate collagenous and elastic structures in live and fixed animal tissues, as well as in collagen-containing biomaterials.

  12. Aircraft Oxygen Generation

    Science.gov (United States)

    2012-02-01

    aircraft use some form of on-board oxygen generation provided by one of two corporations that dominate this market . A review of safety incident data...manufacture of synthetic resins (e.g., Bakelite), and for 161 making dyestuffs, flavorings, perfumes , and other chemicals. Some are used as

  13. Robots for Aircraft Maintenance

    Science.gov (United States)

    1993-01-01

    Marshall Space Flight Center charged USBI (now Pratt & Whitney) with the task of developing an advanced stripping system based on hydroblasting to strip paint and thermal protection material from Space Shuttle solid rocket boosters. A robot, mounted on a transportable platform, controls the waterjet angle, water pressure and flow rate. This technology, now known as ARMS, has found commercial applications in the removal of coatings from jet engine components. The system is significantly faster than manual procedures and uses only minimal labor. Because the amount of "substrate" lost is minimal, the life of the component is extended. The need for toxic chemicals is reduced, as is waste disposal and human protection equipment. Users of the ARMS work cell include Delta Air Lines and the Air Force, which later contracted with USBI for development of a Large Aircraft Paint Stripping system (LARPS). LARPS' advantages are similar to ARMS, and it has enormous potential in military and civil aircraft maintenance. The technology may also be adapted to aircraft painting, aircraft inspection techniques and paint stripping of large objects like ships and railcars.

  14. Aircraft Emissions Characterization

    Science.gov (United States)

    1988-03-01

    sample from each trap through a heated (1500C) six-port valve ’ Carle Instruments Model 5621) and onto the analytical column. The coLoponents in each...Environmental Protection, Vol. II. Aircraft Engine Emissions, Int. Civil Aviation Organ., 1981. 7. Nebel , G. J., "Benzene in Auto Exhaust," J. Air Poll

  15. Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment.

    Science.gov (United States)

    Barkan, Dalit; El Touny, Lara H; Michalowski, Aleksandra M; Smith, Jane Ann; Chu, Isabel; Davis, Anne Sally; Webster, Joshua D; Hoover, Shelley; Simpson, R Mark; Gauldie, Jack; Green, Jeffrey E

    2010-07-15

    Breast cancer that recurs as metastatic disease many years after primary tumor resection and adjuvant therapy seems to arise from tumor cells that disseminated early in the course of disease but did not develop into clinically apparent lesions. These long-term surviving, disseminated tumor cells maintain a state of dormancy, but may be triggered to proliferate through largely unknown factors. We now show that the induction of fibrosis, associated with deposition of type I collagen (Col-I) in the in vivo metastatic microenvironment, induces dormant D2.0R cells to form proliferative metastatic lesions through beta1-integrin signaling. In vitro studies using a three-dimensional culture system modeling dormancy showed that Col-I induces quiescent D2.0R cells to proliferate through beta1-integrin activation of SRC and focal adhesion kinase, leading to extracellular signal-regulated kinase (ERK)-dependent myosin light chain phosphorylation by myosin light chain kinase and actin stress fiber formation. Blocking beta1-integrin, Src, ERK, or myosin light chain kinase by short hairpin RNA or pharmacologic approaches inhibited Col-I-induced activation of this signaling cascade, cytoskeletal reorganization, and proliferation. These findings show that fibrosis with Col-I enrichment at the metastatic site may be a critical determinant of cytoskeletal reorganization in dormant tumor cells, leading to their transition from dormancy to metastatic growth. Thus, inhibiting Col-I production, its interaction with beta1-integrin, and downstream signaling of beta1-integrin may be important strategies for preventing or treating recurrent metastatic disease.

  16. Braking performance of aircraft tires

    Science.gov (United States)

    Agrawal, Satish K.

    This paper brings under one cover the subject of aircraft braking performance and a variety of related phenomena that lead to aircraft hydroplaning, overruns, and loss of directional control. Complex processes involving tire deformation, tire slipping, and fluid pressures in the tire-runway contact area develop the friction forces for retarding the aircraft; this paper describes the physics of these processes. The paper reviews the past and present research efforts and concludes that the most effective way to combat the hazards associated with aircraft landings and takeoffs on contaminated runways is by measuring and displaying in realtime the braking performance parameters in the aircraft cockpit.

  17. Studying Impact Damage on Carbon-Fiber Reinforced Aircraft Composite Panels with Sonicir

    Science.gov (United States)

    Han, Xiaoyan; Zhao, Xinyue; Zhang, Ding; He, Qi; Song, Yuyang; Lubowicki, Anthony; Newaz, Golam.; Favro, Lawrence D.; Thomas, Robert L.

    2011-06-01

    Composites are becoming more important materials in commercial aircraft structures such as the fuselage and wings with the new B787 Dreamliner from Boeing which has the target to utilize 50% by weight of composite materials. Carbon-fiber reinforced composites are the material of choice in aircraft structures. This is due to their light weight and high strength (high strength-to-weight ratio), high specific stiffness, tailorability of properties, design flexibility etc. Especially, by reducing the aircraft's body weight by using such lighter structures, the cost of fuel can be greatly reduced with the high jet fuel price for commercial airlines. However, these composites are prone to impact damage and the damage may occur without any observable sign on the surface, yet resulting in delaminations and disbonds that may occur well within the layers. We are studying the impact problem with carbon-fiber reinforced composite panels and developing SonicIR for this application as a fast and wide-area NDE technology. In this paper, we present our results in studying composite structures including carbon-fiber reinforced composite materials, and preliminary quantitative studies on delamination type defect depth identification in the panels.

  18. Modeling of aircraft exhaust emissions and infrared spectra for remote measurement of nitrogen oxides

    Directory of Open Access Journals (Sweden)

    K. Beier

    Full Text Available Infrared (IR molecular spectroscopy is proposed to perform remote measurements of NOx concentrations in the exhaust plume and wake of aircraft. The computer model NIRATAM is applied to simulate the physical and chemical properties of the exhaust plume and to generate low resolution IR spectra and synthetical thermal images of the aircraft in its natural surroundings. High-resolution IR spectra of the plume, including atmospheric absorption and emission, are simulated using the molecular line-by-line radiation model FASCODE2. Simulated IR spectra of a Boeing 747-400 at cruising altitude for different axial and radial positions in the jet region of the exhaust plume are presented. A number of spectral lines of NO can be identified that can be discriminated from lines of other exhaust gases and the natural atmospheric background in the region around 5.2 µm. These lines can be used to determine NO concentration profiles in the plume. The possibility of measuring nitrogen dioxide NO2 is also discussed briefly, although measurements turn out to be substantially less likely than those of NO. This feasibility study compiles fundamental data for the optical and radiometric design of an airborne Fourier transform spectrometer and the preparation of in-flight measurements for monitoring of aircraft pollutants.

  19. Implementation of Extreme STOL Capability in Cruise Efficient Aircraft Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Aerotonomy, Incorporated, the Georgia Tech Research Institute, and the Boeing Company propose here to continue work towards the development of commercially viable...

  20. Skeletal phenotypes in adult patients with osteogenesis imperfecta-correlations with COL1A1/COL1A2 genotype and collagen structure

    DEFF Research Database (Denmark)

    Hald, J D; Folkestad, L; Harsløf, T

    2016-01-01

    Osteogenesis imperfecta (OI) is characterized by a high fracture rate and great heterogeneity. This cross-sectional study presents skeletal investigations and protein analyses in 85 adult OI patients. We find significant differences in bone mass, architecture, and fracture rate that correlate well...... of this study was to improve our understanding of clinical manifestations by investigating anthropometry and skeletal phenotypes (DXA, HRpQCT) in an adult OI population and compare the findings to underlying COL-1 genotype and structure. METHODS: The study comprised 85 OI patients aged 45 (19-78) years...

  1. Effects of Different Exercise Modes on the MHC- Ⅱ, COL- I and COL-Ⅲ in Healing Process of Acute Skeletal Muscle Injury of Rats%不同运动方式对大鼠骨骼肌急性拉伤修复过程中MHC-Ⅱ,COL-Ⅰ、COL-Ⅲ的影响

    Institute of Scientific and Technical Information of China (English)

    廖远朋; 矫玮

    2011-01-01

    Purpose To investigate the effect of eccentric and concentric exercises on the fibrosis and the regeneration in acute skeletal muscle sprain healing process. Methods One hundred and twenty adult female SD rats were divided randomly into 6 groups: blank control group (BC, ? = 8) , immediate after acute sprain group (IM? N = 8) , first week after acute sprain group (1W? N = 8) , natural-healing group (NH, n = 32) , concentric-exercise group (CE, n = 32) and eccentric-exercise group (EE, n = 32) . One week after the acute muscle sprain, the CE group and EE group were respectively carried on concentric exercise and eccentric exercise for a total of 4 weeks. Gastrocnemius inIM group. 1W group, and BC group was drawn immediate. 7 days and 18 days after the acute muscle sprain, and in the others was drawn 14 days, 21 days, 28 days and 35 days after the acute muscle sprain, respectively. The MHC-II (myosin heavy chain-II) , and collagen type I (COL-1 ) and type III (COL-HI) were detected through immunohistochemistry. Results The concentric exercise accelerated the synthesis of MHC- II and the eccentric exercise accelerated the synthesis of COL-M in the whole process of healing, especially in early stage; both of the eccentric and concentric exercise decreased COL-1. Conclusion The concentric exercise promotes and accelerates the regeneration process by increasing the MHC- II; and both of them inhibit the fibrosis process, especially the concentric exercise. Eccentric exercises endows the injured muscle with better strength and mechanical stability in early stage and promotes the fibrosis process in the later stage of the healing process by increasing COL- M.%目的:了解不同运动方式(离心运动、向心运动)对骨骼肌拉伤愈合过程中肌肉再生和纤维化过程的影响.方法:将120只成年雌性SD大鼠随机分为空白组(BC组,n=8)、即刻组(IM组,n=8)、第1周组(1W组,n=8)、自然愈合组(NC组,n=32)、向心运动组(CE组,n=32)

  2. 19 CFR 10.183 - Duty-free entry of civil aircraft, aircraft engines, ground flight simulators, parts, components...

    Science.gov (United States)

    2010-04-01

    ... Duty-free entry of civil aircraft, aircraft engines, ground flight simulators, parts, components, and... aircraft, aircraft engines, and ground flight simulators, including their parts, components, and... United States (HTSUS) by meeting the following requirements: (1) The aircraft, aircraft engines,...

  3. Numerical simulation of aircraft crash on nuclear containment structure

    Energy Technology Data Exchange (ETDEWEB)

    Iqbal, M.A., E-mail: iqbalfce@iitr.ernet.in [Department of Civil Engineering, Indian Institute of Technology Roorkee, Roorkee 247667 (India); Rai, S.; Sadique, M.R.; Bhargava, P. [Department of Civil Engineering, Indian Institute of Technology Roorkee, Roorkee 247667 (India)

    2012-02-15

    Highlights: Black-Right-Pointing-Pointer The deformation was more localised at the center of cylindrical portion. Black-Right-Pointing-Pointer The peak deflection at the junction of dome and cylinder was found to be 67 mm. Black-Right-Pointing-Pointer The peak deflection at midpoint of the cylindrical portion was found to be 88.9 mm. Black-Right-Pointing-Pointer The strain rate was found to be an important parameter to effect the deformation. Black-Right-Pointing-Pointer The model without strain rate and 290 s{sup -1} strain rate predicted very high deformations. - Abstract: Numerical simulations were carried with ABAQUS/Explicit finite element code in order to predict the response of BWR Mark III type nuclear containment against Boeing 707-320 aircraft crash. The load of the aircraft was applied using and force history curve. The damaged plasticity model was used to predict the behavior of concrete while the Johnson-Cook elasto-viscoplastic material model was used to incorporate the behavior of steel reinforcement. The crash was considered to occur at two different locations i.e., the midpoint of the cylindrical portion and the junction of dome and cylinder. The midpoint of the cylindrical portion experienced more deformation. The strain rate in the material model was varied and found to have a significant effect on the response of containment. The results of the present investigation were compared with those of the studies available in literature and a close agreement with the previous results was found in terms of maximum target deformation.

  4. Influence of Machine-Derived Smoke Yields on Biomarker of Exposure (BOE Levels in Cigarette Smokers*

    Directory of Open Access Journals (Sweden)

    Scherer Gerhard

    2015-01-01

    Full Text Available Individual uptake of tobacco smoke constituents by smoking is highly variable in cigarette smokers and cannot be predicted by smoking behaviour variables and machine-derived smoke yields. It is well established that uptake of smoke constituents is best described by a series of bio-markers of exposure (BOEs such as metabolites of nico-tine, tobacco-specific nitrosamines (TSNAs, polycyclic aromatic hydrocarbons (PAHs, aromatic amines, benzene, 1,3-butadiene, acrolein, hydrogen cyanide, 2,5-dimethyl-furan and other smoke constituents.

  5. Boeing 777 Airplane ACARS and Analysis of Missing of Malaysia Airline MH370%波音777飞机ACARS系统及马航MH370航班失联事件分析

    Institute of Scientific and Technical Information of China (English)

    安乐

    2015-01-01

    The missing of Malaysia Airline’ s MH370 caused a lot of speculation from the media and the public. One focus of speculation is how the ACARS aboard the Boeing 777 airplane which flew MH370 was closed. From the professional point of view, this paper firstly describes the architecture and human-machine interface of Boeing 777 airplane ACARS with System modeling language ( SysML) modeling approach. Then the paper gives the in-depth analysis of the scenario of how the ACARS on MH370 was closed. At last, this paper presents the problems that exposed in this missing event and corresponding remedies.%马来西亚航空公司MH370客机失联事件一度引发媒体与公众的诸多猜测,猜测的焦点之一就是执飞的波音777飞机的飞机通信寻址与报告系统( Aircraft Communication Addressing and Reporting System,简称ACARS)功能是如何被关闭的。从专业角度出发,首先采用SysML建模的方式描述了波音777飞机ACARS系统的详细架构和人机接口,并据此深入分析了马航MH370航班失联事件中ACARS被关闭的情景。最后,提出了此次事件暴露出的现代民用飞机设计中存在的问题以及改进方法。

  6. Aerodynamic Analysis of the Truss-Braced Wing Aircraft Using Vortex-Lattice Superposition Approach

    Science.gov (United States)

    Ting, Eric Bi-Wen; Reynolds, Kevin Wayne; Nguyen, Nhan T.; Totah, Joseph J.

    2014-01-01

    The SUGAR Truss-BracedWing (TBW) aircraft concept is a Boeing-developed N+3 aircraft configuration funded by NASA ARMD FixedWing Project. This future generation transport aircraft concept is designed to be aerodynamically efficient by employing a high aspect ratio wing design. The aspect ratio of the TBW is on the order of 14 which is significantly greater than those of current generation transport aircraft. This paper presents a recent aerodynamic analysis of the TBW aircraft using a conceptual vortex-lattice aerodynamic tool VORLAX and an aerodynamic superposition approach. Based on the underlying linear potential flow theory, the principle of aerodynamic superposition is leveraged to deal with the complex aerodynamic configuration of the TBW. By decomposing the full configuration of the TBW into individual aerodynamic lifting components, the total aerodynamic characteristics of the full configuration can be estimated from the contributions of the individual components. The aerodynamic superposition approach shows excellent agreement with CFD results computed by FUN3D, USM3D, and STAR-CCM+. XXXXX Demand for green aviation is expected to increase with the need for reduced environmental impact. Most large transports today operate within the best cruise L/D range of 18-20 using the conventional tube-and-wing design. This configuration has led to marginal improvements in aerodynamic efficiency over this past century, as aerodynamic improvements tend to be incremental. A big opportunity has been shown in recent years to significantly reduce structural weight or trim drag, hence improved energy efficiency, with the use of lightweight materials such as composites. The Boeing 787 transport is an example of a modern airframe design that employs lightweight structures. High aspect ratio wing design can provide another opportunity for further improvements in energy efficiency. Historically, the study of high aspect ratio wings has been intimately tied to the study of

  7. SUPPLY CHAIN FEATURES OF THE AEROSPACE INDUSTRY PARTICULAR CASE AIRBUS AND BOEING

    OpenAIRE

    Daniela MOCENCO

    2015-01-01

    Aerospace sector is one of the most globalized industries in terms of market structure and production system. Through aircraft development programs aviation industry has introduced new solutions to develop its products. The role of the partners involved in the development programs for the new generation aircraft is becoming increasingly important. Supply chain management has become a key factor for major manufacturers in the industry. The new strategies introduced by the aircraft manufacturer...

  8. High mutation detection rate in the COL4A5 collagen gene in suspected Alport syndrome using PCR and direct DNA sequencing

    DEFF Research Database (Denmark)

    Martin, P; Heiskari, N; Zhou, J

    1998-01-01

    Approximately 85% of patients with Alport syndrome (hereditary nephritis) have been estimated to have mutations in the X chromosomal COL4A5 collagen gene; the remaining cases are autosomal with mutations in the COL4A3 or COL4A4 genes located on chromosome 2. In the present work, the promoter...

  9. Aircraft Data Acquisition

    OpenAIRE

    Elena BALMUS

    2016-01-01

    The introduction of digital systems instead of analog ones has created a major separation in the aviation technology. Although the digital equipment made possible that the increasingly faster controllers take over, we should say that the real world remains essentially analogue [4]. Fly-by-wire designers attempting to control and measure the real feedback of an aircraft were forced to find a way to connect the analogue environment to their digital equipment. In order to manage the implications...

  10. Airline and Aircraft Reliability

    OpenAIRE

    Hauka, Maris; Paramonovs, Jurijs

    2014-01-01

    Development of the inspection programme of fatigue-prone aircraft construction under limitation of airline fatigue failure rate. The highest economical effectiveness of airline under limitation of fatigue failure rate and failure probability is discussed. For computing is used exponential regression, Monte Carlo method, Log Normal distribution, Markov chains and semi-Markov process theory. The minimax approach is offered for processing the results of full-scale fatigue approval test of an air...

  11. Slotted Aircraft Wing

    Science.gov (United States)

    McLean, James D. (Inventor); Witkowski, David P. (Inventor); Campbell, Richard L. (Inventor)

    2006-01-01

    A swept aircraft wing includes a leading airfoil element and a trailing airfoil element. At least one full-span slot is defined by the wing during at least one transonic condition of the wing. The full-span slot allows a portion of the air flowing along the lower surface of the leading airfoil element to split and flow over the upper surface of the trailing airfoil element so as to achieve a performance improvement in the transonic condition.

  12. COL1A1/COL1A2基因突变分析与成骨不全的产前基因诊断%Gene mutation analysis of COL1A1/COL1A2 and prenatal genetic diagnosis of osteogenesis imperfecta

    Institute of Scientific and Technical Information of China (English)

    李焕铮; 唐少华; 毛义建; 谢丙乐

    2012-01-01

    Objective: In this study, the patients with OI pregnancy history were required to have ultrasound ( US) examination and COL1A1/COL1A2 gene mutation detection. It is helpful to establish a clinical protocol for OI patient and provide the technical security for prenatal diagnosis. Methods: The pregnant woman with Oi pregnancy history must be monitored by US. According to ultra-sonography of fetal femur and long bone, it was diagnosed as OI. Amniotic fluid was drawn from pregnant woman with ultrasound abnormality. The sample was detected for COL1A1 and C0L1A2 mutations using direct sequencing. According to the result of new mutation detection, the COL1A1 and C0L1A2 genetic mutation for all family members were detected and analyzed. Identification of maternal blood contamination must be done before tests. Results; The ultrasound imaging showed that the fetus' femur was short, tibiofibula was angled bend, skull was thinning and multiple fractures were found. So we consider fetus was OI. The sample was identified without maternal blood contamination by STR. The COL1A1 of fetus was identified with 19 SNP loci, but no mutation was found. The C0L1A2 was identified with 13 SNP loci, and a G and A heterozygosis mutation at the exon 36 was found. The pregnant woman was found with the same mutation, but the clinical picture was different. Other members were tested with no detectable mutation. Conclusion; The pregnant woman with OI pregnancy history would be monitored by US and detected by genetic tests. It is very import for the sake of birth defects prevention.%目的 对有成骨不全(Osteogenesis Imperfecta,OI)孕史的患者,进行系统B超及COLtA1/COL1A2基因检测,希望建立OI患儿产前诊断方案,为OI患儿进行产前诊断提供技术保障.方法 对于有OI孕史的孕妇,进行系统B超监测;根据胎儿股骨、长骨的超声影像学表现,初诊为成骨不全.抽取羊水,采用直接测序法对羊水DNA的COL1A1和COL1A2基因全编码外显子

  13. Porencephaly in a fetus and HANAC in her father: variable expression of COL4A1 mutation.

    Science.gov (United States)

    Takenouchi, Toshiki; Ohyagi, Masaki; Torii, Chiharu; Kosaki, Rika; Takahashi, Takao; Kosaki, Kenjiro

    2015-01-01

    COL4A1-associated disorders encompass a wide range of hereditary vasculopathy, including porencephaly and HANAC (adult-onset hemorrhagic stroke with cerebral aneurysm and retinal arterial tortuosity, renal cysts, and thenar muscle cramp). It remains elusive whether or not porencephaly and HANAC are molecularly distinctive disorders due to different classes of mutations. We report on a girl with porencephaly and an episode of microangiopathic hemolysis in infancy and her father with HANAC, both of whom had a heterozygous missense mutation of COL4A1 (c.3715G>A, p.G1239R). The current observation implies phenotypic diversities of COL4A1 mutations.

  14. Interaction of Aircraft Wakes From Laterally Spaced Aircraft

    Science.gov (United States)

    Proctor, Fred H.

    2009-01-01

    Large Eddy Simulations are used to examine wake interactions from aircraft on closely spaced parallel paths. Two sets of experiments are conducted, with the first set examining wake interactions out of ground effect (OGE) and the second set for in ground effect (IGE). The initial wake field for each aircraft represents a rolled-up wake vortex pair generated by a B-747. Parametric sets include wake interactions from aircraft pairs with lateral separations of 400, 500, 600, and 750 ft. The simulation of a wake from a single aircraft is used as baseline. The study shows that wake vortices from either a pair or a formation of B-747 s that fly with very close lateral spacing, last longer than those from an isolated B-747. For OGE, the inner vortices between the pair of aircraft, ascend, link and quickly dissipate, leaving the outer vortices to decay and descend slowly. For the IGE scenario, the inner vortices ascend and last longer, while the outer vortices decay from ground interaction at a rate similar to that expected from an isolated aircraft. Both OGE and IGE scenarios produce longer-lasting wakes for aircraft with separations less than 600 ft. The results are significant because concepts to increase airport capacity have been proposed that assume either aircraft formations and/or aircraft pairs landing on very closely spaced runways.

  15. Explorant el treball a la blogosfera: la paradoxa de l’aprenentatge col·laboratiu

    Directory of Open Access Journals (Sweden)

    Jorge Lizandra Mora

    2016-06-01

    Full Text Available Amb l’objectiu de solucionar diversos problemes que sorgiren en la posada en pràctica d’una experiència d’innovació basada en la creació d’una blogosfera, es portà a terme una investigació educativa i qualitativa a partir de la col·laboració docent i de les opinions de l’alumnat. A més dels aspectes positius, es detectaren dificultats amb la gestió del treball en equipo i de familiarització amb la ferramenta a les que els propis estudiants proposaren diverses solucions. Abordar aquesta circumstància de forma col·laborativa i donant veu a l’alumnat ha permès que l’experiència concloguera exitosament, resultant ser una bona pràctica educativa.

  16. Structural constraints on the evolution of the collagen fibril: convergence on a 1014-residue COL domain.

    Science.gov (United States)

    Slatter, David Anthony; Farndale, Richard William

    2015-05-01

    Type I collagen is the fundamental component of the extracellular matrix. Its α1 gene is the direct descendant of ancestral fibrillar collagen and contains 57 exons encoding the rod-like triple-helical COL domain. We trace the evolution of the COL domain from a primordial collagen 18 residues in length to its present 1014 residues, the limit of its possible length. In order to maintain and improve the essential structural features of collagen during evolution, exons can be added or extended only in permitted, non-random increments that preserve the position of spatially sensitive cross-linkage sites. Such sites cannot be maintained unless the twist of the triple helix is close to 30 amino acids per turn. Inspection of the gene structure of other long structural proteins, fibronectin and titin, suggests that their evolution might have been subject to similar constraints.

  17. Somatic mosaicism and the phenotypic expression of COL2A1 mutations.

    Science.gov (United States)

    Nagendran, Sonali; Richards, Allan J; McNinch, Annie; Sandford, Richard N; Snead, Martin P

    2012-05-01

    Mutations in COL2A1, the gene for type II-collagen, can result in a wide variety of phenotypes depending upon the nature of the mutation. Dominant negative mutations tend to result in severe and often lethal skeletal dysplasias such as achondrogenesis type 2, Kniest dysplasia, and spondyloepiphyseal dysplasia congenita. Stickler syndrome, a condition characterized by ophthalmological and orofacial features, deafness and arthritis, usually, but not exclusively, results from haploinsufficiency. Overlapping features of all these disorders can also be seen in the same family. Rare reports have demonstrated that phenotypic variability can be explained in some families by somatic mosaicism. Here, we describe five further examples of somatic mosaicism of COL2A1 mutations illustrating the importance of detailed clinical evaluation and molecular testing even in clinically normal parents of affected individuals.

  18. Estudio del proceso de transformación del colágeno en gelatina

    OpenAIRE

    Bonmatí Limorte, María del Carmen; León Albert, Gerardo

    1983-01-01

    Se ha realizado un estudio del proceso de transformación de colágeno en gelatina utilizando la viscosidad reducida como parámetro de control. Se ha observado una gran influencia de la temperatura y del tiempo de calentamiento sobre este proceso, así como sobre la temperatura de desnaturalización. Se han determinado igualmente las entalpia y entropía de desnaturalización.

  19. Views of Astronaut (Col.) Joe Engle and son Jon with L-5 Piper Cub

    Science.gov (United States)

    1981-01-01

    Views of Astronaut (Col.) Joe Engle and son Jon with L-5 Piper Cub at Clover Airport. Photos includes Jon Engle sitting on side door frame working on portion of wing. Joe Engle is behind him working on a wing strut (34329); Joe Engle works on tightening bolt (34330); Jon Engle works on portion of wing which connects to the cockpit. Joe Engle works on connecting strut to wing (34331).

  20. Colômbia 2010: Guerra, Paz e Eleições

    Directory of Open Access Journals (Sweden)

    Luiz Antônio Gusmão

    2009-02-01

    Full Text Available

    O enfraquecimento das Farc deve polarizar as

    eleições de 2010 na Colômbia entre recrudescimento

    do combate e abertura à negociação.

  1. Synergistic interaction of platelet derived growth factor (PDGF) with the surface of PLLA/Col/HA and PLLA/HA scaffolds produces rapid osteogenic differentiation.

    Science.gov (United States)

    Raghavendran, Hanumantha Rao Balaji; Mohan, Saktiswaren; Genasan, Krishnamurithy; Murali, Malliga Raman; Naveen, Sangeetha Vasudevaraj; Talebian, Sepehr; McKean, Robert; Kamarul, Tunku

    2016-03-01

    Scaffolds with structural features similar to the extracellular matrix stimulate rapid osteogenic differentiation in favorable microenvironment and with growth factor supplementation. In this study, the osteogenic potential of electrospun poly-l-lactide/hydroxyapatite/collagen (PLLA/Col/HA, PLLA/HA and PLLA/Col) scaffolds were tested in vitro with the supplementation of platelet derived growth factor-BB (PDGF-BB). Cell attachment and topography, mineralization, extracellular matrix protein localization, and gene expression of the human mesenchymal stromal cells were compared between the fibrous scaffolds PLLA/Col/HA, PLLA/Col, and PLLA/HA. The levels of osteocalcin, calcium, and mineralization were significantly greater in the PLLA/Col/HA and PLLA/HA compared with PLLA/Col. High expression of fibronectin, intracellular adhesion molecule, cadherin, and collagen 1 (Col1) suggests that PLLA/Col/HA and PLLA/HA scaffolds had superior osteoinductivity than PLLA/Col. Additionally, osteopontin, osteocalcin, osterix, Runt-related transcription factor 2 (Runx2), and bone morphogenic protein (BMP2) expression were higher in PLLA/Col/HA and PLLA/HA compared with PLLA/Col. In comparison with PLLA/Col, the PLLA/Col/HA and PLLA/HA scaffolds presented a significant upregulation of the genes Runx2, Col 1, Integrin, osteonectin (ON), bone gamma-carboxyglutamic acid-containing protein (BGALP), osteopontin (OPN), and BMP2. The upregulation of these genes was further increased with PDGF-BB supplementation. These results show that PDGF-BB acts synergistically with PLLA/Col/HA and PLLA/HA to enhance the osteogenic differentiation potential. Therefore, this combination can be used for the rapid expansion of bone marrow stromal cells into bone-forming cells for tissue engineering.

  2. Generation of Col2a1-EGFP iPS cells for monitoring chondrogenic differentiation.

    Directory of Open Access Journals (Sweden)

    Taku Saito

    Full Text Available Induced pluripotent stem cells (iPSC are a promising cell source for cartilage regenerative medicine; however, the methods for chondrocyte induction from iPSC are currently developing and not yet sufficient for clinical application. Here, we report the establishment of a fluorescent indicator system for monitoring chondrogenic differentiation from iPSC to simplify screening for effective factors that induce chondrocytes from iPSC. We generated iPSC from embryonic fibroblasts of Col2a1-EGFP transgenic mice by retroviral transduction of Oct4, Sox2, Klf4, and c-Myc. Among the 30 clones of Col2a1-EGFP iPSC we established, two clones showed high expression levels of embryonic stem cell (ESC marker genes, similar to control ESC. A teratoma formation assay showed that the two clones were pluripotent and differentiated into cell types from all three germ layers. The fluorescent signal was observed during chondrogenic differentiation of the two clones concomitant with the increase in chondrocyte marker expression. In conclusion, Col2a1-EGFP iPSC are useful for monitoring chondrogenic differentiation and will contribute to research in cartilage regenerative medicine.

  3. A COL4A5 mutation with glomerular disease and signs of chronic thrombotic microangiopathy.

    Science.gov (United States)

    Wuttke, Matthias; Seidl, Maximilian; Malinoc, Angelica; Prischl, Friedrich C; Kuehn, E Wolfgang; Walz, Gerd; Köttgen, Anna

    2015-12-01

    COL4A5 mutations are a known cause of Alport syndrome, which typically manifests with haematuria, hearing loss and ocular symptoms. Here we report on a 16-year-old male patient with a negative family history who presented with proteinuria, progressive renal failure and haemolysis, but without overt haematuria or hearing loss. A renal biopsy revealed features of atypical IgA nephropathy, while a second biopsy a year later showed features of focal segmental glomerulosclerosis, but was finally diagnosed as chronic thrombotic microangiopathy. Targeted sequencing of candidate genes for steroid-resistant nephrotic syndrome and congenital thrombotic microangiopathy was negative. Despite all therapeutic efforts, including angiotensin-converting enzyme inhibition, immunosuppressive therapy, plasma exchanges and rituximab, the patient progressed to end-stage renal disease. When a male cousin presented with nephrotic syndrome years later, whole-exome sequencing identified a shared disruptive COL4A5 mutation (p.F222C) that showed X-linked segregation. Thus, mutations in COL4A5 give rise to a broader spectrum of clinical presentation than commonly suspected, highlighting the benefits of comprehensive rather than candidate genetic testing in young patients with otherwise unexplained glomerular disease. Our results are in line with an increasing number of atypical presentations of single-gene disorders identified through genome-wide sequencing.

  4. Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations.

    Science.gov (United States)

    Gray, Ryan S; Wilm, Thomas P; Smith, Jeff; Bagnat, Michel; Dale, Rodney M; Topczewski, Jacek; Johnson, Stephen L; Solnica-Krezel, Lilianna

    2014-02-01

    Congenital vertebral malformations (CVM) occur in 1 in 1000 live births and in many cases can cause spinal deformities, such as scoliosis, and result in disability and distress of affected individuals. Many severe forms of the disease, such as spondylocostal dystostosis, are recessive monogenic traits affecting somitogenesis, however the etiologies of the majority of CVM cases remain undetermined. Here we demonstrate that morphological defects of the notochord in zebrafish can generate congenital-type spine defects. We characterize three recessive zebrafish leviathan/col8a1a mutant alleles ((m531, vu41, vu105)) that disrupt collagen type VIII alpha1a (col8a1a), and cause folding of the embryonic notochord and consequently adult vertebral column malformations. Furthermore, we provide evidence that a transient loss of col8a1a function or inhibition of Lysyl oxidases with drugs during embryogenesis was sufficient to generate vertebral fusions and scoliosis in the adult spine. Using periodic imaging of individual zebrafish, we correlate focal notochord defects of the embryo with vertebral malformations (VM) in the adult. Finally, we show that bends and kinks in the notochord can lead to aberrant apposition of osteoblasts normally confined to well-segmented areas of the developing vertebral bodies. Our results afford a novel mechanism for the formation of VM, independent of defects of somitogenesis, resulting from aberrant bone deposition at regions of misshapen notochord tissue.

  5. Guidance Systems of Fighter Aircraft

    Directory of Open Access Journals (Sweden)

    K.N. Rajanikanth

    2005-07-01

    Full Text Available Mission performance of a fighter aircraft is crucial for survival and strike capabilities in todays' aerial warfare scenario. The guidance functions of such an aircraft play a vital role inmeeting the requirements and accomplishing the mission success. This paper presents the requirements of precision guidance for various missions of a fighter aircraft. The concept ofguidance system as a pilot-in-loop system is pivotal in understanding and designing such a system. Methodologies of designing such a system are described.

  6. Guidance Systems of Fighter Aircraft

    OpenAIRE

    K.N. Rajanikanth; Rao, R S; P. S. Subramanyam; Ajai Vohra

    2005-01-01

    Mission performance of a fighter aircraft is crucial for survival and strike capabilities in todays' aerial warfare scenario. The guidance functions of such an aircraft play a vital role inmeeting the requirements and accomplishing the mission success. This paper presents the requirements of precision guidance for various missions of a fighter aircraft. The concept ofguidance system as a pilot-in-loop system is pivotal in understanding and designing such a system. Methodologies of designing s...

  7. Preliminary Research on Boeing 737 NG Pacific Conditioners RNAV Operation%波音737NG太平洋调机RNAV运行可行性初探

    Institute of Scientific and Technical Information of China (English)

    方学东; 肖真真

    2011-01-01

    Due to early voyage of the property parameters, such as restraint, Boeing 737 aircraft was operated according to Seattle-Hawaii-Marshall islands- Saipan island route. The performance of B737-NG was improved to increase the aircraft flight distance. Without pay load, the MAX Range could be achieved to make Hawaii-Saipan non-stop RNAV operation possibly. Through analysis the premise condition and airborne navigation equipment performance of the RNAV operation.. In the great circle route model , planning on the Hawaiian-Saipan direct route, with B737-800 for example, quantitative calculation the fuel consumption. Hawaii-Saipan direct route than traditional Hawaiian-Marshall islands-Saipan routes shorten 688 kilometers. In the strong dead wind condition , the wind speed is 50 kn/h, oil sailing less than 15 tons. After related training of flight crew and equipped with full-time navigator, the civil aviation Boeing 737-NG has the feasibility of non-stop flight , reduce a take-off and landing and the time will shorter 0. 8 hour.%波音737的早期机型由于受到航程等性能参数的制约,按照西雅图—夏威夷—马绍尔群岛—塞班岛的航路运行.波音737NG对飞机的性能进行了改进,增大了飞机的航程.调机飞行时,波音737NG无业载情况下可达到最大航程,为夏威夷—塞班岛的直飞RNAV运行提供了可能性.通过RNAV运行的前提条件和机载导航设备性能分析,在大圆航线模型下对夏威夷—塞班岛直飞航线进行了航路规划,并以B737-800机型为实例,对耗油量等进行了定量计算.夏威夷—塞班岛直飞航线比传统夏威夷—马绍尔群岛—塞班岛航线缩短688 km,在50 km/h强顶风状态下飞行,航行用油小于15t,说明在机组经过相关培训并配备专职领航员的条件下,波音737NG太平洋调机具有夏威夷—塞班岛直飞的可行性,减少一次起降并缩短约0.8h飞行时间.

  8. Scheduling of an aircraft fleet

    Science.gov (United States)

    Paltrinieri, Massimo; Momigliano, Alberto; Torquati, Franco

    1992-01-01

    Scheduling is the task of assigning resources to operations. When the resources are mobile vehicles, they describe routes through the served stations. To emphasize such aspect, this problem is usually referred to as the routing problem. In particular, if vehicles are aircraft and stations are airports, the problem is known as aircraft routing. This paper describes the solution to such a problem developed in OMAR (Operative Management of Aircraft Routing), a system implemented by Bull HN for Alitalia. In our approach, aircraft routing is viewed as a Constraint Satisfaction Problem. The solving strategy combines network consistency and tree search techniques.

  9. 75 FR 50859 - Airworthiness Directives; The Boeing Company Model 737-600, -700, -700C, -800, and -900 Series...

    Science.gov (United States)

    2010-08-18

    ... Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707, MC 2H-65, Seattle... assembly and through the housing. AirTran asserts that an arc of this significance would trip the currently... conditions identified in the NPRM. CAL contends that the use of arc fault circuit interrupters (AFCIs) is...

  10. 75 FR 38014 - Airworthiness Directives; The Boeing Company Model 737-200, -300, -400, and -500 Series Airplanes

    Science.gov (United States)

    2010-07-01

    ...., Washington, DC 20590. FOR FURTHER INFORMATION CONTACT: Nicholas Wilson, Aerospace Engineer, Cabin Safety and... Boeing Special Attention Service Bulletin 737-35-1099, Revision 1, dated April 23, 2009, which refers to B/E Aerospace Service Bulletin 174080-35-01, dated February 6, 2006; Revision 1, dated May 1,...

  11. 76 FR 44246 - Special Conditions: Boeing Model 747-8 Series Airplanes; Overhead Flight Attendant Rest Compartment

    Science.gov (United States)

    2011-07-25

    ... detection and fire suppression systems) in conjunction with an OFAR fire to be a catastrophic event. Based... airplanes. These airplanes will have novel or unusual design features associated with the installation of an... issued for other novel or unusual design features of Boeing 747-8 airplanes. DATES: Effective...

  12. 75 FR 43803 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Science.gov (United States)

    2010-07-27

    ... FR 67027, December 1, 2003). (3) For service information identified in this AD, contact Boeing... spindles, and to prevent severe flap asymmetry, which could result in reduced control or loss of..., 2010. On December 4, 2003 (68 FR 67027, December 1, 2003), the Director of the Federal...

  13. 78 FR 76731 - Special Conditions: Boeing Model 777-200, -300, and -300ER Series Airplanes; Rechargeable Lithium...

    Science.gov (United States)

    2013-12-19

    ... Series Airplanes; Rechargeable Lithium Ion Batteries and Battery Systems AGENCY: Federal Aviation... lithium ion batteries and battery system that will be used on an International Communications Group (ICG... uses rechargeable lithium ion batteries and battery systems in the Boeing Model 777-200, -300,...

  14. The Boeing Company's Tech Prep Story: A Community College Bridge to the School-to-Work Strategy.

    Science.gov (United States)

    Gayton, Carver; Parnell, Dale

    1996-01-01

    Reviews the Boeing Tech Prep Program, an associate degree program combining high school and community college vocational and academic curricula. Describes the three phases of the program's development: the provision of seed grants to schools, the development of an associate degree program, and the institution of an internship program. (MAB)

  15. Volume da gota dos colírios lubrificantes: estudo farmacoeconômico

    Directory of Open Access Journals (Sweden)

    Alexandre Xavier da Costa

    2015-12-01

    Full Text Available RESUMO Objetivo: Determinar o volume médio das gotas produzidas pelos colírios lubrificantes em diferentes ângulos de inclinação e determinar o custo médio do tratamento. Métodos: Determinação do volume da gota de 3 frascos originais dos colírios lubrificantes Artelac®, Hylo Comod®, Lacrima® Plus, Systane® UL, Lacrifilm®, Hyabak®, Lacribell®, Ecofilm®, Mirugell®, Plenigell®, Fresh Tears®, Optive® e Endura® à inclinação de 90º e 45º. Determinou-se o número médio de gotas em cada frasco e foi feita avaliação farmacoeconômica dos colírios. Resultados: O volume das gotas variou de 32,2 a 64,0 µL a 45o e de 29,1 a 65,1 µL a 90o. A diferença entre as gotas em cada inclinação foi de 2 a 24% e o custo anual dos colírios de acordo com a inclinação variou de R$2,73 a R$130,73. A Duração Máxima de Tratamento (DMT foi de 29,3 a 51,4 dias na inclinação de 45o, e de 28,8 a 48,4 dias a 90º, sendo que a diferença na DMT foi de 0,5 até 8 dias a mais ou a menos, de acordo com a marca. Conclusão: Nenhum dos colírios estudados apresentou gotas ideais para o olho humano, levando a um desperdício do produto e maior custo para o fabricante e para o consumidor. Percebemos que existe uma variação significativa no volume da gota de acordo com a inclinação do frasco, e que uma variação maior do que 10% traria impactos financeiros para o paciente.

  16. Stickler syndrome caused by COL2A1 mutations: genotype-phenotype correlation in a series of 100 patients

    DEFF Research Database (Denmark)

    Hoornaert, Kristien P; Vereecke, Inge; Dewinter, Chantal;

    2010-01-01

    in COL2A1. In 188 probands with the clinical diagnosis of Stickler syndrome, the COL2A1 gene was analyzed by either a mutation scanning technique or bidirectional fluorescent DNA sequencing. The effect of splice site alterations was investigated by analyzing mRNA. Multiplex ligation......-dependent amplification analysis was used for the detection of intragenic deletions. We identified 77 different COL2A1 mutations in 100 affected individuals. Analysis of the splice site mutations showed unusual RNA isoforms, most of which contained a premature stop codon. Vitreous anomalies and retinal detachments were...... found more frequently in patients with a COL2A1 mutation compared with the mutation-negative group (P90% of the mutations were predicted to result in nonsense-mediated decay. On the basis of binary regression analysis, we developed a scoring system that may be useful when evaluating patients...

  17. Optics in aircraft engines

    Science.gov (United States)

    Vachon, James; Malhotra, Subhash

    The authors describe optical IR&D (independent research and development) programs designed to demonstrate and evaluate optical technologies for incorporation into next-generation military and commercial aircraft engines. Using a comprehensive demonstration program to validate this technology in an on-engine environment, problems encountered can be resolved early and risk can be minimized. In addition to specific activities related to the optics demonstration on the fighter engine, there are other optical programs underway, including a solenoid control system, a light off detection system, and an optical communication link. Research is also underway in simplifying opto-electronics and exploiting multiplexing to further reduce cost and weight.

  18. Aircraft propeller control

    Science.gov (United States)

    Day, Stanley G. (Inventor)

    1990-01-01

    In the invention, the speeds of both propellers in a counterrotating aircraft propeller pair are measured. Each speed is compared, using a feedback loop, with a demanded speed and, if actual speed does not equal demanded speed for either propeller, pitch of the proper propeller is changed in order to attain the demanded speed. A proportional/integral controller is used in the feedback loop. Further, phase of the propellers is measured and, if the phase does not equal a demanded phase, the speed of one propeller is changed, by changing pitch, until the proper phase is attained.

  19. Commercial Aircraft Protection

    Energy Technology Data Exchange (ETDEWEB)

    Ehst, David A. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-10-26

    This report summarizes the results of theoretical research performed during 3 years of P371 Project implementation. In results of such research a new scientific conceptual technology of quasi-passive individual infrared protection of heat-generating objects – Spatial Displacement of Thermal Image (SDTI technology) was developed. Theoretical substantiation and description of working processes of civil aircraft individual IR-protection system were conducted. The mathematical models and methodology were presented, there were obtained the analytical dependencies which allow performing theoretical research of the affect of intentionally arranged dynamic field of the artificial thermal interferences with variable contrast onto main parameters of optic-electronic tracking and homing systems.

  20. Chemistry in aircraft plumes

    Energy Technology Data Exchange (ETDEWEB)

    Kraabol, A.G.; Stordal, F.; Knudsen, S. [Norwegian Inst. for Air Research, Kjeller (Norway); Konopka, P. [Deutsche Forschungsanstalt fuer Luft- und Raumfahrt e.V. (DLR), Wessling (Germany). Inst. fuer Physik der Atmosphaere

    1997-12-31

    An expanding plume model with chemistry has been used to study the chemical conversion of NO{sub x} to reservoir species in aircraft plumes. The heterogeneous conversion of N{sub 2}O{sub 5} to HNO{sub 3}(s) has been investigated when the emissions take place during night-time. The plume from an B747 has been simulated. During a ten-hour calculation the most important reservoir species was HNO{sub 3} for emissions at noon. The heterogeneous reactions had little impact on the chemical loss of NO{sub x} to reservoir species for emissions at night. (author) 4 refs.

  1. Hydrogen aircraft technology

    Science.gov (United States)

    Brewer, G. D.

    1991-01-01

    A comprehensive evaluation is conducted of the technology development status, economics, commercial feasibility, and infrastructural requirements of LH2-fueled aircraft, with additional consideration of hydrogen production, liquefaction, and cryostorage methods. Attention is given to the effects of LH2 fuel cryotank accommodation on the configurations of prospective commercial transports and military airlifters, SSTs, and HSTs, as well as to the use of the plentiful heatsink capacity of LH2 for innovative propulsion cycles' performance maximization. State-of-the-art materials and structural design principles for integral cryotank implementation are noted, as are airport requirements and safety and environmental considerations.

  2. The ColRS system of Xanthomonas oryzae pv. oryzae is required for virulence and growth in iron-limiting conditions.

    Science.gov (United States)

    Subramoni, Sujatha; Pandey, Alok; Vishnu Priya, M R; Patel, Hitendra Kumar; Sonti, Ramesh V

    2012-09-01

    Xanthomonas oryzae pv. oryzae, the causal agent of bacterial blight of rice, produces siderophores only under iron-limiting conditions. We screened 15 400 mTn5-induced mutants of X. oryzae pv. oryzae and isolated 27 mutants that produced siderophores even under iron-replete conditions. We found that the mTn5 insertions in 25 of these mutants were in or close to six genes. Mutants with insertions in five of these genes [colS, XOO1806 (a conserved hypothetical protein), acnB, prpR and prpB] exhibited a deficiency for growth on iron-limiting medium and a decrease in virulence. Insertions in a sixth gene, XOO0007 (a conserved hypothetical protein), were found to affect the ability to grow on iron-limiting medium, but did not affect the virulence. Targeted gene disruptants for colR (encoding the predicted cognate regulatory protein for ColS) also exhibited a deficiency for growth on iron-limiting medium and a decrease in virulence. colR and colS mutants were defective in the elicitation of hypersensitive response symptoms on the nonhost tomato. In addition, colR and colS mutants induced a rice basal defence response, suggesting that they are compromised in the suppression of host innate immunity. Quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis demonstrated that a functional ColRS system is required for the optimal expression of several genes encoding components of the type 3 secretion system (T3SS) of X. oryzae pv. oryzae. Our results demonstrate the role of several novel genes, including colR/colS, in the promotion of growth on iron-limiting medium and the virulence of X. oryzae pv. oryzae.

  3. The 1989-1990 eruption of Redoubt Volcano, Alaska: impacts on aircraft operations

    Science.gov (United States)

    Casadevall, T.J.

    1994-01-01

    The December 1989-June 1990 eruption of Redoubt Volcano affected commercial and military air operations in the vicinity of Anchorage, Alaska. These effects were due to the direct impact of volcanic ash on jet aircraft, as well as to the rerouting and cancellations of flight operations owing to eruptive activity. Between December and February, five commercial jetliners were damaged from ash encounters. The most serious incident took place on December 15, 1989 when a Boeing 747-400 aircraft temporarily lost power of all four engines after encountering an ash cloud as the airplane descended for a landing in Anchorage. While there were no injuries to passengers, the damage to engines, avionics, and aircraft structure from this encounter is estimated at $80 million. Four additional encounters between jet aircraft and Redoubt ash clouds occurred in the Anchorage area on December 15 and 16, 1989 and February 21, 1990; none resulted in engine failure. Two additional encounters took place on December 17, 1989 when jet airliners encountered the Redoubt cloud over west Texas. At the time of these encounters, the cloud was up to 55 hours old and had traveled in excess of 2,900 nautical miles (5,300 km). Following the December 15 encounters, Anchorage International Airport remained open, however, most airline companies canceled operations for up to several days. As communications between Federal agencies and airlines improved, and as a better understanding of the nature and behavior of ash-rich eruption clouds was achieved, most airlines resumed normal service by early January 1990. The resulting loss of revenue at Anchorage International Airport during several months following the eruption is estimated to total $2.6 million. The impact on general aviation and military operations consisted mostly of cancellation and rerouting of flights. ?? 1994.

  4. An Object-Oriented Computer Code for Aircraft Engine Weight Estimation

    Science.gov (United States)

    Tong, Michael T.; Naylor, Bret A.

    2009-01-01

    Reliable engine-weight estimation at the conceptual design stage is critical to the development of new aircraft engines. It helps to identify the best engine concept amongst several candidates. At NASA Glenn Research Center (GRC), the Weight Analysis of Turbine Engines (WATE) computer code, originally developed by Boeing Aircraft, has been used to estimate the engine weight of various conceptual engine designs. The code, written in FORTRAN, was originally developed for NASA in 1979. Since then, substantial improvements have been made to the code to improve the weight calculations for most of the engine components. Most recently, to improve the maintainability and extensibility of WATE, the FORTRAN code has been converted into an object-oriented version. The conversion was done within the NASA's NPSS (Numerical Propulsion System Simulation) framework. This enables WATE to interact seamlessly with the thermodynamic cycle model which provides component flow data such as airflows, temperatures, and pressures, etc., that are required for sizing the components and weight calculations. The tighter integration between the NPSS and WATE would greatly enhance system-level analysis and optimization capabilities. It also would facilitate the enhancement of the WATE code for next-generation aircraft and space propulsion systems. In this paper, the architecture of the object-oriented WATE code (or WATE++) is described. Both the FORTRAN and object-oriented versions of the code are employed to compute the dimensions and weight of a 300-passenger aircraft engine (GE90 class). Both versions of the code produce essentially identical results as should be the case.

  5. MISSILES AND AIRCRAFT (PART1

    Directory of Open Access Journals (Sweden)

    C.M. Meyer

    2012-02-01

    Full Text Available Many sources maintain that the role played by air power in the 1973 Yom Kippur War was important. Other interpretations state that control of air space over the battlefield areas, (either by aircraft or anti-aircraft defences, was vital.

  6. Study and progress of collagen Ⅳ gene COL4A1 mutations%Ⅳ型胶原基因COL4A1突变的研究进展

    Institute of Scientific and Technical Information of China (English)

    安丽梅; 夏欣一

    2011-01-01

    Ⅳ型胶原蛋白基因α1 (COL4A1)编码Ⅳ型胶原的α1链,是各种组织基底膜的主要结构成分.基底膜由胶原、层粘连蛋白、蛋白多糖和巢蛋白组成,在所有胶原成分中,最重要的是Ⅳ型胶原.COL4A1基因突变能引起多种疾病,在一定的环境压力下会引发HANAC综合征、肾病、孔洞脑、白内障等疾病.本文主要从COL4A1的结构、组成及在基底膜中的作用等方面,对COI4A1基因突变引发的人类疾病及其发病机制进行综述.%α1 type IV collagen (COL4A1) encodes the α1 chain of type Ⅳ collagen. Collagen type Ⅳ is the most abundant structural BM component in a variety of tissues. In general, Basement membranes ( BMs) are composed of collagens, laminins, perle-can, and nidogens. Collagen IV is important to BM. Mutations in COL4A1 gene have been linked to a spectrum of diverse diseases caused by abnormalities of these molecules in the kidney, brain and eyes. In this review, we will cover, after a short overview of the molecular basis of the COL4A1 and the main BM components, the current knowledge of diseases caused by COL4A1 mutations and summarize the possible mechanisms of mutations and human diseases.

  7. 75 FR 81427 - Airworthiness Directives; The Boeing Company Model 747-200C, -200F, -400, -400D, and -400F Series...

    Science.gov (United States)

    2010-12-28

    ... Certain Language in Paragraph (k) of the NPRM Boeing asked that we revise the language in paragraph (k) of... Information Japan Airlines (JAL) asked that we delay issuance until the manufacturer can release Revision 2...

  8. Mission Analysis and Conceptual Design of a Space Ambulance Utilizing the Boeing X-37B Platform

    Science.gov (United States)

    Blaesser, Nathaniel James

    This paper discusses the concept of operations and modifications for a crew return vehicle from the International Space Station based on the Boeing X-37B platform. The modifications necessary include accommodating a three person crew, adding an environmental control and life support system and modifying the propulsion system to be more conducive to a fast evacuation. Two crew seating configurations were considered and traded for vehicle mass, crew envelope and ease of loading and unloading the injured patient. Computer models were generated to determine key parameters, and the models were validated using physical mock-ups. The mission is considerably shorter than the design reference mission, meaning that there are significant reductions in propellant mass and volume. The results showed that by utilizing the space saved from smaller propellant tanks, and combining the crew's oxygen supply with the propulsion system, the vehicle can be retooled without modifying the outer mold line..

  9. Modelling exhaust plume mixing in the near field of an aircraft

    Directory of Open Access Journals (Sweden)

    F. Garnier

    Full Text Available A simplified approach has been applied to analyse the mixing and entrainment processes of the engine exhaust through their interaction with the vortex wake of an aircraft. Our investigation is focused on the near field, extending from the exit nozzle until about 30 s after the wake is generated, in the vortex phase. This study was performed by using an integral model and a numerical simulation for two large civil aircraft: a two-engine Airbus 330 and a four-engine Boeing 747. The influence of the wing-tip vortices on the dilution ratio (defined as a tracer concentration shown. The mixing process is also affected by the buoyancy effect, but only after the jet regime, when the trapping in the vortex core has occurred. In the early wake, the engine jet location (i.e. inboard or outboard engine jet has an important influence on the mixing rate. The plume streamlines inside the vortices are subject to distortion and stretching, and the role of the descent of the vortices on the maximum tracer concentration is discussed. Qualitative comparison with contrail photograph shows similar features. Finally, tracer concentration of inboard engine centreline of B-747 are compared with other theoretical analyses and measured data.

  10. Lewis icing research tunnel test of the aerodynamic effects of aircraft ground deicing/anti-icing fluids

    Science.gov (United States)

    Runyan, L. James; Zierten, Thomas A.; Hill, Eugene G.; Addy, Harold E., Jr.

    1992-01-01

    A wind tunnel investigation of the effect of aircraft ground deicing/anti-icing fluids on the aerodynamic characteristics of a Boeing 737-200ADV airplane was conducted. The test was carried out in the NASA Lewis Icing Research Tunnel. Fluids tested include a Newtonian deicing fluid, three non-Newtonian anti-icing fluids commercially available during or before 1988, and eight new experimental non-Newtonian fluids developed by four fluid manufacturers. The results show that fluids remain on the wind after liftoff and cause a measurable lift loss and drag increase. These effects are dependent on the high-lift configuration and on the temperature. For a configuration with a high-lift leading-edge device, the fluid effect is largest at the maximum lift condition. The fluid aerodynamic effects are related to the magnitude of the fluid surface roughness, particularly in the first 30 percent chord. The experimental fluids show a significant reduction in aerodynamic effects.

  11. A novel COL11A1 mutation affecting splicing in a patient with Stickler syndrome.

    Science.gov (United States)

    Kohmoto, Tomohiro; Naruto, Takuya; Kobayashi, Haruka; Watanabe, Miki; Okamoto, Nana; Masuda, Kiyoshi; Imoto, Issei; Okamoto, Nobuhiko

    2015-01-01

    Stickler syndrome is a clinically and genetically heterogeneous collagenopathy characterized by ocular, auditory, skeletal and orofacial abnormalities, commonly occurring as an autosomal dominant trait. We conducted target resequencing to analyze candidate genes associated with known clinical phenotypes from a 4-year-old girl with Stickler syndrome. We detected a novel heterozygous intronic mutation (NM_001854.3:c.3168+5G>A) in COL11A1 that may impair splicing, which was suggested by in silico prediction and a minigene assay.

  12. Colágeno asimilable. Fuente de prevención de enfermedades osteoarticuladas

    OpenAIRE

    Parra Parra, Yolanda; Quesada Martínez, María Inmaculada; Pérez Collado, Elisa María

    2015-01-01

    Cartel presentado en la Segunda Conferencia Internacional de Comunicación en Salud, celebrada el 23 de octubre de 2015 en la Universidad Carlos III de Madrid Introducción: El colágeno es la proteína más abundante de nuestro cuerpo humano y uno de sus componentes esencial de articulaciones, cartílago, ligamento, tendones, huesos, piel. Su especial estructura lo hacen único, presenta una estructura fibrosa, que aporta gran resistencia y flexibilidad a los tejidos de los que forma parte. Cu...

  13. Col-OSSOS: A new ugrJ taxonomy for trans-Neptunian objects

    Science.gov (United States)

    Fraser, Wesley Cristopher; Bannister, Michele T.; Marsset, Michael; Pike, Rosemary E.; Schwamb, Megan E.; Kavelaars, J. J.; Benecchi, Susan D.; Delsanti, Audrey; Lehner, Matt J.; Wang, Shiang-Yu; Thirouin, Audrey; Guilbert-Lepoutre, Aurelie; Peixinho, Nuno; Vernazza, Pierre

    2016-10-01

    The surfaces of trans-Neptunian objects (TNOs) are poorly understood. Very little has been discerned about the compositions of most small TNOs. In recent years however, some concrete knowledge about the surface colour distribution of TNOs has come to light. It is now generally accepted that small TNOs fall into at least three classes of object based on their surface colours and albedo. Despite nearly two decades of gathering TNO surface information however, a taxonomy has still not been agreed upon. From Col-OSSOS u, g, r, and J photometry, we find significantly different clustering of (u-g) colour in the optically red, dynamically cold TNOs as compared to similarly optically coloured dynamically excited TNOs. One of the goals of the Colours of the Outer Solar System Origins Survey is the development of a robust TNO taxonomy. This 4 year program which started in 2014B is simultaneously using the Gemini-North and Canada-France-Hawaii telescopes to gather near simultaneous u, g, r, and J spectral photometry of all targets in the Outer Solar System Origins Survey (OSSOS) brighter than r'=23.6 (120 expected). The focus of Col-OSSOS is completeness and consistency, with the same SNR=25 being reached in all bands, for all targets brighter than our depth limit. Col-OSSOS will provide the first brightness-complete, compositional-dynamical map of the Outer Solar System, from which key hypotheses about the Solar System's cosmogony can be tested. After an overview of the survey's design and techniques, we will present the observed colours from the first complete block. Even with just ~30 targets, the precise photometry afforded by Col-OSSOS has already revealed the existence of 3 separate TNO taxons or classes, which become obvious when their (u-g), (g-r), and (r-J) colours are considered together. In particular, the so-called cold classical TNOs, which stand out because of their dynamically quiescent orbits, while possessing similar (g-r) and (r-J) colours as other red TNOs

  14. Influencia de pesticidas en las poblaciones de Colémbolos

    OpenAIRE

    Durán Vicente, Alberto M.

    2013-01-01

    El efecto de los insecticidas en las poblaciones de Colémbolos fue investigado en una finca de frutales en la localidad de Nitra (Eslovaquia). El estudio se hizo en dos parcelas, una en la que se aplicaron insecticidas de manera esporádica y controlada, y la otra, en la cual no se habian utilizado pesticidas desde hacía años. Los tratamientos fueron establecidos para investigar la influencia de los insectos presentes sobre y bajo la capa superficial del suelo, en la sucesión vegetal. Lo...

  15. Commercial aircraft composite technology

    CERN Document Server

    Breuer, Ulf Paul

    2016-01-01

    This book is based on lectures held at the faculty of mechanical engineering at the Technical University of Kaiserslautern. The focus is on the central theme of societies overall aircraft requirements to specific material requirements and highlights the most important advantages and challenges of carbon fiber reinforced plastics (CFRP) compared to conventional materials. As it is fundamental to decide on the right material at the right place early on the main activities and milestones of the development and certification process and the systematic of defining clear requirements are discussed. The process of material qualification - verifying material requirements is explained in detail. All state-of-the-art composite manufacturing technologies are described, including changes and complemented by examples, and their improvement potential for future applications is discussed. Tangible case studies of high lift and wing structures emphasize the specific advantages and challenges of composite technology. Finally,...

  16. Aircraft control system

    Science.gov (United States)

    Lisoski, Derek L. (Inventor); Kendall, Greg T. (Inventor)

    2007-01-01

    A solar rechargeable, long-duration, span-loaded flying wing, having no fuselage or rudder. Having a two-hundred foot wingspan that mounts photovoltaic cells on most all of the wing's top surface, the aircraft uses only differential thrust of its eight propellers to turn, pitch and yaw. The wing is configured to deform under flight loads to position the propellers such that the control can be achieved. Each of five segments of the wing has one or more motors and photovoltaic arrays, and produces its own lift independent of the other segments, to avoid loading them. Five two-sided photovoltaic arrays, in all, are mounted on the wing, and receive photovoltaic energy both incident on top of the wing, and which is incident also from below, through a bottom, transparent surface.

  17. Aircraft recognition and pose estimation

    Science.gov (United States)

    Hmam, Hatem; Kim, Jijoong

    2000-05-01

    This work presents a geometry based vision system for aircraft recognition and pose estimation using single images. Pose estimation improves the tracking performance of guided weapons with imaging seekers, and is useful in estimating target manoeuvres and aim-point selection required in the terminal phase of missile engagements. After edge detection and straight-line extraction, a hierarchy of geometric reasoning algorithms is applied to form line clusters (or groupings) for image interpretation. Assuming a scaled orthographic projection and coplanar wings, lateral symmetry inherent in the airframe provides additional constraints to further reject spurious line clusters. Clusters that accidentally pass all previous tests are checked against the original image and are discarded. Valid line clusters are then used to deduce aircraft viewing angles. By observing that the leading edges of wings of a number of aircraft of interest are within 45 to 65 degrees from the symmetry axis, a bounded range of aircraft viewing angles can be found. This generic property offers the advantage of not requiring the storage of complete aircraft models viewed from all aspects, and can handle aircraft with flexible wings (e.g. F111). Several aircraft images associated with various spectral bands (i.e. visible and infra-red) are finally used to evaluate the system's performance.

  18. NASA-UVA Light Aerospace Alloy and Structure Technology Program Supplement: Aluminum-Based Materials for High Speed Aircraft

    Science.gov (United States)

    Starke, E. A., Jr.

    1997-01-01

    This is the final report of the study "Aluminum-Based Materials for High Speed Aircraft" which had the objectives (1) to identify the most promising aluminum-based materials with respect to major structural use on the HSCT and to further develop those materials and (2) to assess the materials through detailed trade and evaluation studies with respect to their structural efficiency on the HSCT. The research team consisted of ALCOA, Allied-Signal, Boeing, McDonnell Douglas, Reynolds Metals and the University of Virginia. Four classes of aluminum alloys were investigated: (1) I/M 2XXX containing Li and I/M 2XXX without Li, (2) I/M 6XXX, (3) two P/M 2XXX alloys, and (4) two different aluminum-based metal matrix composites (MMC). The I/M alloys were targeted for a Mach 2.0 aircraft and the P/M and MMC alloys were targeted for a Mach 2.4 aircraft. Design studies were conducted using several different concepts including skin/stiffener (baseline), honeycomb sandwich, integrally stiffened and hybrid adaptations (conventionally stiffened thin-sandwich skins). Alloy development included fundamental studies of coarsening behavior, the effect of stress on nucleation and growth of precipitates, and fracture toughness as a function of temperature were an integral part of this program. The details of all phases of the research are described in this final report.

  19. 40 CFR 87.6 - Aircraft safety.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Aircraft safety. 87.6 Section 87.6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF AIR POLLUTION FROM AIRCRAFT AND AIRCRAFT ENGINES General Provisions § 87.6 Aircraft safety. The provisions...

  20. 14 CFR 21.6 - Manufacture of new aircraft, aircraft engines, and propellers.

    Science.gov (United States)

    2010-01-01

    ... Manufacture of new aircraft, aircraft engines, and propellers. (a) Except as specified in paragraphs (b) and (c) of this section, no person may manufacture a new aircraft, aircraft engine, or propeller based on... provisions of §§ 21.183(c), 21.184(b), or 21.185(c); and (2) New aircraft engines or propellers...

  1. 78 FR 54385 - Airworthiness Directives; Various Aircraft Equipped With Rotax Aircraft Engines 912 A Series Engine

    Science.gov (United States)

    2013-09-04

    ... Aircraft Equipped With Rotax Aircraft Engines 912 A Series Engine AGENCY: Federal Aviation Administration... directive (AD) for various aircraft equipped with Rotax Aircraft Engines 912 A Series Engine. This AD...; phone: +43 7246 601 0; fax: +43 7246 601 9130; Internet: http://www.rotax-aircraft-engines.com . You...

  2. Auto-imunidade e colágeno V Autoimmunity and collagen V

    Directory of Open Access Journals (Sweden)

    Cristiane Carla de Oliveira

    2006-06-01

    Full Text Available As proteínas da matriz extracelular (MEC e seus componentes estão sendo amplamente estudados na literatura médica, assim como sua relação com o remodelamento tecidual presente nas doenças reumáticas. Neste artigo, mostramos a importância do estudo do colágeno do tipo V no entendimento da etiologia da esclerodermia, no que se refere ao desencadeamento da auto-imunidade nesta enfermidade. Estudos em nosso laboratório demonstram que a sensibilização com colágeno do tipo V em coelhos pode resultar em um modelo animal de esclerodermia. Diante destes fatos, sugerimos que pesquisas neste campo podem ser de grande valia no desenvolvimento de novas condutas terapêuticas.The extracellular matrix (ECM proteins and their components have been widely studied in medical literature, as well its relationship with the tecidual remodeling present in the rheumatic disease. In this paper we show the importance of understanding the role of type V collagen as an important trigger of rheumatic autoimmune diseases. Studies in our laboratory demonstrate that type V collagen sensibilization in rabbits, could result in an animal scleroderma model. In this way we suggested that researches in this field can be worthy in development of new therapeutic procedures.

  3. Artificial Autopolyploidization Modifies the Tricarboxylic Acid Cycle and GABA Shunt in Arabidopsis thaliana Col-0.

    Science.gov (United States)

    Vergara, Fredd; Kikuchi, Jun; Breuer, Christian

    2016-05-23

    Autopolyploidy is a process whereby the chromosome set is multiplied and it is a common phenomenon in angiosperms. Autopolyploidy is thought to be an important evolutionary force that has led to the formation of new plant species. Despite its relevance, the consequences of autopolyploidy in plant metabolism are poorly understood. This study compares the metabolic profiles of natural diploids and artificial autotetraploids of Arabidopsis thaliana Col-0. Different physiological parameters are compared between diploids and autotetraploids using nuclear magnetic resonance (NMR), elemental analysis (carbon:nitrogen balance) and quantitative real-time PCR (qRT-PCR). The main difference between diploid and autotetraploid A. thaliana Col-0 is observed in the concentration of metabolites related to the tricarboxylic acid cycle (TCA) and γ-amino butyric acid (GABA) shunt, as shown by multivariate statistical analysis of NMR spectra. qRT-PCR shows that genes related to the TCA and GABA shunt are also differentially expressed between diploids and autotetraploids following similar trends as their corresponding metabolites. Solid evidence is presented to demonstrate that autopolyploidy influences core plant metabolic processes.

  4. Artificial Autopolyploidization Modifies the Tricarboxylic Acid Cycle and GABA Shunt in Arabidopsis thaliana Col-0

    Science.gov (United States)

    Vergara, Fredd; Kikuchi, Jun; Breuer, Christian

    2016-05-01

    Autopolyploidy is a process whereby the chromosome set is multiplied and it is a common phenomenon in angiosperms. Autopolyploidy is thought to be an important evolutionary force that has led to the formation of new plant species. Despite its relevance, the consequences of autopolyploidy in plant metabolism are poorly understood. This study compares the metabolic profiles of natural diploids and artificial autotetraploids of Arabidopsis thaliana Col-0. Different physiological parameters are compared between diploids and autotetraploids using nuclear magnetic resonance (NMR), elemental analysis (carbon:nitrogen balance) and quantitative real-time PCR (qRT-PCR). The main difference between diploid and autotetraploid A. thaliana Col-0 is observed in the concentration of metabolites related to the tricarboxylic acid cycle (TCA) and γ-amino butyric acid (GABA) shunt, as shown by multivariate statistical analysis of NMR spectra. qRT-PCR shows that genes related to the TCA and GABA shunt are also differentially expressed between diploids and autotetraploids following similar trends as their corresponding metabolites. Solid evidence is presented to demonstrate that autopolyploidy influences core plant metabolic processes.

  5. Loss of Col3a1, the gene for Ehlers-Danlos syndrome type IV, results in neocortical dyslamination.

    Directory of Open Access Journals (Sweden)

    Sung-Jin Jeong

    Full Text Available It has recently been discovered that Collagen III, the encoded protein of the type IV Ehlers-Danlos Syndrome (EDS gene, is one of the major constituents of the pial basement membrane (BM and serves as the ligand for GPR56. Mutations in GPR56 cause a severe human brain malformation called bilateral frontoparietal polymicrogyria, in which neurons transmigrate through the BM causing severe mental retardation and frequent seizures. To further characterize the brain phenotype of Col3a1 knockout mice, we performed a detailed histological analysis. We observed a cobblestone-like cortical malformation, with BM breakdown and marginal zone heterotopias in Col3a1⁻/⁻ mouse brains. Surprisingly, the pial BM appeared intact at early stages of development but starting as early as embryonic day (E 11.5, prominent BM defects were observed and accompanied by neuronal overmigration. Although collagen III is expressed in meningeal fibroblasts (MFs, Col3a1⁻/⁻ MFs present no obvious defects. Furthermore, the expression and posttranslational modification of α-dystroglycan was undisturbed in Col3a1⁻/⁻ mice. Based on the previous finding that mutations in COL3A1 cause type IV EDS, our study indicates a possible common pathological pathway linking connective tissue diseases and brain malformations.

  6. COL-3, a chemically modified tetracycline, inhibits lipopolysaccharide-induced microglia activation and cytokine expression in the brain.

    Science.gov (United States)

    Edan, Rawan Abdulhameed; Luqmani, Yunus A; Masocha, Willias

    2013-01-01

    Microglia activation results in release of proinflammatory molecules including cytokines, which contribute to neuronal damage in the central nervous system (CNS) if not controlled. Tetracycline antibiotics such as minocycline inhibit microglial activation and cytokine expression during CNS inflammation. In the present study we found that administration of chemically modified tetracycline-3 (COL-3), inhibits lipopolysaccharide (LPS)-induced microglial and p38 MAPK activation, as well as the increase in TNF-α, but not IL-1β expression, in the brains of BALB/c mice. COL-3 has been described to have no antibacterial activity. We observed that COL-3 had no activity against a Gram-negative bacteria, Escherichia coli; however surprisingly, COL-3 had antibacterial activity against a Gram-positive bacteria Staphylococcus aureus, with a minimum inhibitory concentration of 1 mg/ml. Our data show that COL-3 has some antibacterial activity against S. aureus, inhibits LPS-induced neuroinflammation, and displays potential as a therapeutic agent for treatment of conditions involving CNS inflammation.

  7. COL-3, a chemically modified tetracycline, inhibits lipopolysaccharide-induced microglia activation and cytokine expression in the brain.

    Directory of Open Access Journals (Sweden)

    Rawan Abdulhameed Edan

    Full Text Available Microglia activation results in release of proinflammatory molecules including cytokines, which contribute to neuronal damage in the central nervous system (CNS if not controlled. Tetracycline antibiotics such as minocycline inhibit microglial activation and cytokine expression during CNS inflammation. In the present study we found that administration of chemically modified tetracycline-3 (COL-3, inhibits lipopolysaccharide (LPS-induced microglial and p38 MAPK activation, as well as the increase in TNF-α, but not IL-1β expression, in the brains of BALB/c mice. COL-3 has been described to have no antibacterial activity. We observed that COL-3 had no activity against a Gram-negative bacteria, Escherichia coli; however surprisingly, COL-3 had antibacterial activity against a Gram-positive bacteria Staphylococcus aureus, with a minimum inhibitory concentration of 1 mg/ml. Our data show that COL-3 has some antibacterial activity against S. aureus, inhibits LPS-induced neuroinflammation, and displays potential as a therapeutic agent for treatment of conditions involving CNS inflammation.

  8. VTOL to Transonic Aircraft Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The cyclogyro, an aircraft propulsion concept with the potential for VTOL to the lower bounds of transonic flight, is conceptually simple but structurally and...

  9. Western Pacific Typhoon Aircraft Fixes

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Western Pacific typhoon aircraft reconnaissance data from the years 1946 - 1965 and 1978, excluding 1952, were transcribed from original documents, or copy of...

  10. Fire resistant aircraft seat program

    Science.gov (United States)

    Fewell, L. A.

    1979-01-01

    Foams, textiles, and thermoformable plastics were tested to determine which materials were fire retardant, and safe for aircraft passenger seats. Seat components investigated were the decorative fabric cover, slip covers, fire blocking layer, cushion reinforcement, and the cushioning layer.

  11. Causes of aircraft electrical failures

    Science.gov (United States)

    Galler, Donald; Slenski, George

    1991-08-01

    The results of a survey of data on failures of aircraft electronic and electrical components that was conducted to identify problematic components are reported. The motivation for the work was to determine priorities for future work on the development of accident investigation techniques for aircraft electrical components. The primary source of data was the Airforce Mishap Database, which is maintained by the Directorate of Aerospace Safety at Norton Air Force Base. Published data from the Air Force Avionics Integrity Program (AVIP) and Hughes Aircraft were also reviewed. Statistical data from these three sources are presented. Two major conclusions are that problems with interconnections are major contributors to aircraft electrical equipment failures, and that environmental factors, especially corrosion, are significant contributors to connector problems.

  12. Aircraft recognition and tracking device

    Science.gov (United States)

    Filis, Dimitrios P.; Renios, Christos I.

    2011-11-01

    The technology of aircraft recognition and tracking has various applications in all areas of air navigation, be they civil or military, spanning from air traffic control and regulation at civilian airports to anti-aircraft weapon handling and guidance for military purposes.1, 18 The system presented in this thesis is an alternative implementation of identifying and tracking flying objects, which benefits from the optical spectrum by using an optical camera built into a servo motor (pan-tilt unit). More specifically, through the purpose-developed software, when a target (aircraft) enters the field of view of the camera18, it is both detected and identified.5, 22 Then the servo motor, being provided with data on target position and velocity, tracks the aircraft while it is in constant communication with the camera (Fig. 1). All the features are so designed as to operate under real time conditions.

  13. Structural Dynamics of Maneuvering Aircraft.

    Science.gov (United States)

    1987-09-01

    AD-RI92 376 STRUCTURAL DYNAMICS OF MANEUVERING RIRCRAFT(U) CONRAD I TECHNOLOGIES INC KING OF PRUSSIA PR M M REDDI SEP 97 CTI-8601 NRDC-88014-69...REPORT NO. NADC-8014-60 STRUCTURAL DYNAMICS OF MANEUVERING AIRCRAFT M. Mahadeva Reddi .4 Conrad Technologies, Inc. 650 S. Henderson Rd. D T IQ King of...NO A0 CCESSION NO. R02303001 107601 11. TITLE (Include Security Classfication) (u) STRUCTURAL DYNAMICS OF MANEUVERING AIRCRAFT 12. PERSONAL AUTHORS) M

  14. Application of winglets and/or wing tip extensions with active load control on the Boeing 747

    Science.gov (United States)

    Allison, R. L.; Perkin, B. R.; Schoenman, R. L.

    1978-01-01

    The application of wing tip modifications and active control technology to the Boeing 747 airplane for the purpose of improving fuel efficiency is considered. Wing tip extensions, wing tip winglets, and the use of the outboard ailerons for active wing load alleviation are described. Modest performance improvements are indicated. A costs versus benefits approach is taken to decide which, if any, of the concepts warrant further development and flight test leading to possible incorporation into production airplanes.

  15. 大型民机企业人力资源能力建设评价研究*%Research on Human Resource Construction Evaluation of Large Aircraft Corporation

    Institute of Scientific and Technical Information of China (English)

    杨生斌; 孙振杰; 孔莹

    2013-01-01

    Large aircraft corporations need strong human resources to support,in view of "I am the Lord", "the Lord manufacturers and suppliers" develop-ment model in China's large aircraft corporations, the importance of corporations internal human resources con-struction is indicated. Through using the benchmarking corporations Boeing and Airbus company human resource practices, from investment, performance and output three aspects, the large aircraft corporations human resources construction evaluation index system and evaluation model are constructed so as to improve human resources con-struction standard of large aircraft corporations in China.%大型民机企业需要强有力的人力资源做支撑,针对我国大型民机企业“以我为主”、“主制造商+供应商”的发展模式,明确企业内部人力资源能力建设的重要性。通过借鉴标杆企业波音和空客的人力资源实践,从投入、表现和产出3方面入手构建了大型民机企业人力资源能力建设评价指标体系和评价模型,以期促进我国大型民机企业人力资源能力不断提升。

  16. A sensitive method for determination of COL-3, a chemically modified tetracycline, in human plasma using high-performance liquid chromatography and ultraviolet detection.

    Science.gov (United States)

    Rudek, Michelle A; Hartke, Carol; Zabelina, Yelena; Zhao, Ming; New, Pamela; Baker, Sharyn D

    2005-04-01

    COL-3, 6-deoxy-6-desmethyl-4-desdimethylamino-tetracycline, is a matrix metalloproteinase inhibitor currently in clinical development. A HPLC-UV method to quantitate COL-3 in human plasma was developed. COL-3 was extracted from plasma using solid-phase extraction cartridges. COL-3 is separated on a Waters Symmetry Shield RP8 (3.9 mm x150 mm, 5 microm) column with EDTA (0.001 M) in sodium acetate (0.01 M, pH 3.5)-acetonitrile mobile phase using a gradient profile at a flow rate of 1 ml/min for 22 min. Carryover was eliminated by using an extended needle wash of methanol:acetonitrile:dichloromethane (1:1:1, v/v/v). Detection of COL-3 and the internal standard, chrysin, was observed at 350 nm. COL-3 and chrysin elute at 8.9 and 9.9 min, respectively. The lower limit of quantitation in human plasma of COL-3 was 75 ng/ml, linearity was observed from 75 to 10,000 ng/ml. A 30,000 ng/ml sample that was diluted 1:50 with plasma was accurately quantitated. This method is rapid, widely applicable, and suitable for quantifying COL-3 in patient samples enabling further clinical pharmacology characterization of COL-3.

  17. Aircraft vibration and flutter

    Directory of Open Access Journals (Sweden)

    R. R. Aggarwal

    1958-04-01

    Full Text Available "The paper outlines the theoretical and experimental procedure one has to adopt for flutter prevention during the various stages (project, design and prototype of the development of modern aircraft. With the advent of high speed, the aerodynamic coefficients have to be calculated with due regards to the effects of compressibility, finite aspect ratio of the lifting surfaces, sweep back and other peculiar shapes of the wings. The use of thin, small aspect ratio with external masses, necessitates the computation of higher frequency modes of vibration. Single degree of freedom flutter and the effect of control surface non-linearities has also become very important. Thus, it is shown how the availability of high speed computing machines, improved experimental technique for model and full scale testing has not kept pace with the uncertainties associated with the transonic speeds, low aspect ratio and the high frequency modes. Cross-checking of theoretical and experimental results at every stage seem to be the only answer."

  18. Aircraft exhaust sulfur emissions

    Energy Technology Data Exchange (ETDEWEB)

    Brown, R.C.; Anderson, M.R.; Miake-Lye, R.C.; Kolb, C.E. [Aerodyne Research, Inc., Billerica, MA (United States). Center for Chemical and Environmental Physics; Sorokin, A.A.; Buriko, Y.I. [Scientific Research Center `Ecolen`, Moscow (Russian Federation)

    1997-12-31

    The extent to which fuel sulfur is converted to SO{sub 3} during combustion and the subsequent turbine flow in supersonic and subsonic aircraft engines is estimated numerically. The analysis is based on: a flamelet model with non-equilibrium sulfur chemistry for the combustor, and a one-dimensional, two-stream model with finite rate chemical kinetics for the turbine. The results indicate that between 2% and 10% of the fuel sulfur is emitted as SO{sub 3}. It is also shown that, for a high fuel sulfur mass loading, conversion in the turbine is limited by the level of atomic oxygen at the combustor exit, leading to higher SO{sub 2} oxidation efficiency at lower fuel sulfur loadings. While SO{sub 2} and SO{sub 3} are the primary oxidation products, the model results further indicate H{sub 2}SO{sub 4} levels on the order of 0.1 ppm for supersonic expansions through a divergent nozzle. This source of fully oxidized S(6) (SO{sub 3} + H{sub 2}SO{sub 4}) exceeds previously calculated S(6) levels due to oxidation of SO{sub 2} by OH in the exhaust plume outside the engine nozzle. (author) 26 refs.

  19. Parabolic aircraft solidification experiments

    Science.gov (United States)

    Workman, Gary L. (Principal Investigator); Smith, Guy A.; OBrien, Susan

    1996-01-01

    A number of solidification experiments have been utilized throughout the Materials Processing in Space Program to provide an experimental environment which minimizes variables in solidification experiments. Two techniques of interest are directional solidification and isothermal casting. Because of the wide-spread use of these experimental techniques in space-based research, several MSAD experiments have been manifested for space flight. In addition to the microstructural analysis for interpretation of the experimental results from previous work with parabolic flights, it has become apparent that a better understanding of the phenomena occurring during solidification can be better understood if direct visualization of the solidification interface were possible. Our university has performed in several experimental studies such as this in recent years. The most recent was in visualizing the effect of convective flow phenomena on the KC-135 and prior to that were several successive contracts to perform directional solidification and isothermal casting experiments on the KC-135. Included in this work was the modification and utilization of the Convective Flow Analyzer (CFA), the Aircraft Isothermal Casting Furnace (ICF), and the Three-Zone Directional Solidification Furnace. These studies have contributed heavily to the mission of the Microgravity Science and Applications' Materials Science Program.

  20. 1,25-Dihydroxyvitamin D3 inhibition of col1a1 promoter expression in calvariae from neonatal transgenic mice

    Science.gov (United States)

    Bedalov, A.; Salvatori, R.; Dodig, M.; Kapural, B.; Pavlin, D.; Kream, B. E.; Clark, S. H.; Woody, C. O.; Rowe, D. W.; Lichtler, A. C.

    1998-01-01

    We studied the effect of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on organ cultures of transgenic mouse calvariae containing segments of the Col1a1 promoter extending to -3518, -2297, -1997, -1794, -1763, and -1719 bp upstream of the transcription start site fused to the chloramphenicol acetyltransferase (CAT) reporter gene. 1,25(OH)2D3 had a dose-dependent inhibitory effect on the expression of the -3518 bp promoter construct (ColCAT3.6), with maximal inhibition of about 50% at 10 nM. This level of inhibition was consistent with the previously observed effect on the endogenous Col1a1 gene in bone cell models. All of the shorter constructs were also inhibited by 10 nM 1,25(OH)2D3, suggesting that the sequences required for 1, 25(OH)2D3 inhibition are downstream of -1719 bp. The inhibitory effect of 1,25(OH)2D3 on transgene mRNA was maintained in the presence of the protein synthesis inhibitor cycloheximide, suggesting that the inhibitory effect on Col1a1 gene transcription does not require de novo protein synthesis. We also examined the in vivo effect of 1,25(OH)2D3 treatment of transgenic mice on ColCAT activity, and found that 48 h treatment caused a dose-dependent inhibition of CAT activity in calvariae comparable to that observed in organ cultures. In conclusion, we demonstrated that 1,25(OH)2D3 inhibits Col1A1 promoter activity in transgenic mouse calvariae, both in vivo and in vitro. The results indicate that there is a 1, 25(OH)2D3 responsive element downstream of -1719 bp. The inhibitory effect does not require new protein synthesis.

  1. Computational fluid dynamics modeling of transport and deposition of pesticides in an aircraft cabin.

    Science.gov (United States)

    Isukapalli, Sastry S; Mazumdar, Sagnik; George, Pradeep; Wei, Binnian; Jones, Byron; Weisel, Clifford P

    2013-04-01

    Spraying of pesticides in aircraft cabins is required by some countries as part of a disinsection process to kill insects that pose a public health threat. However, public health concerns remain regarding exposures of cabin crew and passengers to pesticides in aircraft cabins. While large scale field measurements of pesticide residues and air concentrations in aircraft cabins scenarios are expensive and time consuming, Computational Fluid Dynamics (CFD) models provide an effective alternative for characterizing concentration distributions and exposures. This study involved CFD modeling of a twin-aisle 11 row cabin mockup with heated manikins, mimicking a part of a fully occupied Boeing 767 cabin. The model was applied to study the flow and deposition of pesticides under representative scenarios with different spraying patterns (sideways and overhead) and cabin air exchange rates (low and high). Corresponding spraying experiments were conducted in the cabin mockup, and pesticide deposition samples were collected at the manikin's lap and seat top for a limited set of five seats. The CFD model performed well for scenarios corresponding to high air exchange rates, captured the concentration profiles for middle seats under low air exchange rates, and underestimated the concentrations at window seats under low air exchange rates. Additionally, both the CFD and experimental measurements showed no major variation in deposition characteristics between sideways and overhead spraying. The CFD model can estimate concentration fields and deposition profiles at very high resolutions, which can be used for characterizing the overall variability in air concentrations and surface loadings. Additionally, these model results can also provide a realistic range of surface and air concentrations of pesticides in the cabin that can be used to estimate potential exposures of cabin crew and passengers to these pesticides.

  2. Space and Missile Systems Center Compliance Specifications and Standards

    Science.gov (United States)

    2015-07-31

    mike.wadzinski@mda.mil Alfredo Colón NASA Headquarters alfredo.colon@nasa.gov Jacqueline Kaiser USAF 50th Space Wing jacqueline.kaiser@us.af.mil Timothy Kalt HQ...Lum The Boeing Company joan.l.lu,@boeing.com Beth Snyder The Boeing Company beth.snyder@boeing.com Robert Adkisson The Boeing Company robert.w.adkisson

  3. A novel missense mutation of COL5A2 in a patient with Ehlers–Danlos syndrome

    Science.gov (United States)

    Watanabe, Miki; Nakagawa, Ryuji; Naruto, Takuya; Kohmoto, Tomohiro; Suga, Ken-ichi; Goji, Aya; Kagami, Shoji; Masuda, Kiyoshi; Imoto, Issei

    2016-01-01

    Ehlers–Danlos syndrome (EDS) is a group of inherited connective tissue disorders characterized by hyperextensible skin, joint hypermobility and soft tissue fragility. For molecular diagnosis, targeted exome sequencing was performed on a 9-year-old male patient who was clinically suspected to have EDS. The patient presented with progressive kyphoscoliosis, joint hypermobility and hyperextensible skin without scars. Ultimately, classical EDS was diagnosed by identifying a novel, mono-allelic mutation in COL5A2 [NM_000393.3(COL5A2_v001):c.682G>A, p.Gly228Arg]. PMID:27656288

  4. A novel missense mutation of COL5A2 in a patient with Ehlers-Danlos syndrome.

    Science.gov (United States)

    Watanabe, Miki; Nakagawa, Ryuji; Naruto, Takuya; Kohmoto, Tomohiro; Suga, Ken-Ichi; Goji, Aya; Kagami, Shoji; Masuda, Kiyoshi; Imoto, Issei

    2016-01-01

    Ehlers-Danlos syndrome (EDS) is a group of inherited connective tissue disorders characterized by hyperextensible skin, joint hypermobility and soft tissue fragility. For molecular diagnosis, targeted exome sequencing was performed on a 9-year-old male patient who was clinically suspected to have EDS. The patient presented with progressive kyphoscoliosis, joint hypermobility and hyperextensible skin without scars. Ultimately, classical EDS was diagnosed by identifying a novel, mono-allelic mutation in COL5A2 [NM_000393.3(COL5A2_v001):c.682G>A, p.Gly228Arg].

  5. Actividad Antioxidante de extractos de Calendula officinalis asociados a soportes de colágeno tipo I

    OpenAIRE

    Flórez Cabrera, Adriana Matilde

    2014-01-01

    En este trabajo se evaluó la actividad antioxidante de los metabolitos secundarios presentes en dos extractos, oleoso e hidroglicólico, de flores de Calendula officinalis liberados de forma controlada por soportes de colágeno tipo I con micropartículas de gelatina-colágeno desarrollados mediante ingeniería de tejidos, con el fin determinar su posible aplicación en heridas cutáneas crónicas con elevadas concentraciones de especies reactivas de oxígeno. Se realizaron pruebas de citotoxicida...

  6. Aircraft Cabin Environmental Quality Sensors

    Energy Technology Data Exchange (ETDEWEB)

    Gundel, Lara; Kirchstetter, Thomas; Spears, Michael; Sullivan, Douglas

    2010-05-06

    The Indoor Environment Department at Lawrence Berkeley National Laboratory (LBNL) teamed with seven universities to participate in a Federal Aviation Administration (FAA) Center of Excellence (COE) for research on environmental quality in aircraft. This report describes research performed at LBNL on selecting and evaluating sensors for monitoring environmental quality in aircraft cabins, as part of Project 7 of the FAA's COE for Airliner Cabin Environmental Research (ACER)1 effort. This part of Project 7 links to the ozone, pesticide, and incident projects for data collection and monitoring and is a component of a broader research effort on sensors by ACER. Results from UCB and LBNL's concurrent research on ozone (ACER Project 1) are found in Weschler et al., 2007; Bhangar et al. 2008; Coleman et al., 2008 and Strom-Tejsen et al., 2008. LBNL's research on pesticides (ACER Project 2) in airliner cabins is described in Maddalena and McKone (2008). This report focused on the sensors needed for normal contaminants and conditions in aircraft. The results are intended to complement and coordinate with results from other ACER members who concentrated primarily on (a) sensors for chemical and biological pollutants that might be released intentionally in aircraft; (b) integration of sensor systems; and (c) optimal location of sensors within aircraft. The parameters and sensors were selected primarily to satisfy routine monitoring needs for contaminants and conditions that commonly occur in aircraft. However, such sensor systems can also be incorporated into research programs on environmental quality in aircraft cabins.

  7. COOH-terminal collagen Q (COLQ) mutants causing human deficiency of endplate acetylcholinesterase impair the interaction of ColQ with proteins of the basal lamina.

    Science.gov (United States)

    Arredondo, Juan; Lara, Marian; Ng, Fiona; Gochez, Danielle A; Lee, Diana C; Logia, Stephanie P; Nguyen, Joanna; Maselli, Ricardo A

    2014-05-01

    Collagen Q (ColQ) is a key multidomain functional protein of the neuromuscular junction (NMJ), crucial for anchoring acetylcholinesterase (AChE) to the basal lamina (BL) and accumulating AChE at the NMJ. The attachment of AChE to the BL is primarily accomplished by the binding of the ColQ collagen domain to the heparan sulfate proteoglycan perlecan and the COOH-terminus to the muscle-specific receptor tyrosine kinase (MuSK), which in turn plays a fundamental role in the development and maintenance of the NMJ. Yet, the precise mechanism by which ColQ anchors AChE at the NMJ remains unknown. We identified five novel mutations at the COOH-terminus of ColQ in seven patients from five families affected with endplate (EP) AChE deficiency. We found that the mutations do not affect the assembly of ColQ with AChE to form asymmetric forms of AChE or impair the interaction of ColQ with perlecan. By contrast, all mutations impair in varied degree the interaction of ColQ with MuSK as well as basement membrane extract (BME) that have no detectable MuSK. Our data confirm that the interaction of ColQ to perlecan and MuSK is crucial for anchoring AChE to the NMJ. In addition, the identified COOH-terminal mutants not only reduce the interaction of ColQ with MuSK, but also diminish the interaction of ColQ with BME. These findings suggest that the impaired attachment of COOH-terminal mutants causing EP AChE deficiency is in part independent of MuSK, and that the COOH-terminus of ColQ may interact with other proteins at the BL.

  8. Management of choledochal cyst Tratamento do cisto de colédoco

    Directory of Open Access Journals (Sweden)

    Orlando Jorge Martins Torres

    2007-09-01

    Full Text Available BACKGROUND: Choledochal cysts are rare diseases in adults. The risk of malignant transformation is well documented to be age-related and early complete cyst excision is currently advocated. Type IVa cyst management is more controversial. Extensive intrahepatic involvement of the biliary system may preclude complete excision. AIM: The aim of this study was to present a case of type IVa choledochal cyst in a young female patient. CASE REPORT: An 18-year-old female, complaining of right upper quadrant pain, nausea, vomiting, fever, and jaundice was admitted. The diagnosis of type IVa choledochal cyst was made by computerized tomography. The patient was underwent cholecystectomy, excision of the anterior wall of the cyst, and Roux-en-Y hepaticojejunostomy. No postoperative complication was noted and the patient was discharged five days after operation. CONCLUSION: Total cyst excision is the ideal treatment of choledochal cysts in adults. However, in IVa type, due to the extensive intrahepatic involvement of the biliary system, the anatomy of the cyst, and the surgeon's judgment will determine the surgical approach taken for the patient.RACIONAL: A doença de cistos de colédoco em adultos é rara. O risco de transformação maligna é bem documentado, sendo relacionado a idade, além da completa excisão do cisto ser aconselhada. O manuseio e gestão do cisto tipo IVa gera maior controvérsia. O envolvimento intra-hepático extensivo do sistema biliar pode prevenir a sua completa excisão. OBJETIVOS: Relatar o caso de um cisto de colédoco do tipo IVa em paciente feminina. RELATO DE CASO: Paciente feminina, 18 anos de idade, foi admitida com queixa de dor no quadrante superior direito, náusea, vômitos, febre e icterícia. O diagnóstico de cisto de colédoco do tipo IVa foi realizado através de tomografia computadorizada. A paciente foi submetida à colecistectomia, excisão da parede anterior do cisto e hepatojejunostomia em Y-de-Roux. Nenhuma

  9. Detecten Hepatozoon sp. en una colònia felina de Barcelona

    OpenAIRE

    Ortuño Romero, Anna M.

    2009-01-01

    En un estudi realitzat pel Departament de Sanitat i Anatomia Animals de la Facultat de Veterinària de la UAB, amb el suport del Servei de Salut Pública de la Diputació de Barcelona, s’ha detectat la presència d’Hepatozoon sp. en colònies de gats de carrer. Un fet important donat que és el primer cop que aquests paràsits intracel·lulars són identificats en felins del nord d’Espanya, i perquè, a més a més, evidencia la importància d’establir programes sanitaris que permetin detectar i controlar...

  10. Mutation-based growth charts for SEDC and other COL2A1 related dysplasias

    DEFF Research Database (Denmark)

    Terhal, Paulien A; van Dommelen, Paula; Le Merrer, Martine

    2012-01-01

    patients with glycine substitutions in the triple-helical domain of COL2A1. In addition, measurements of 27 patients with other molecular defects, such as arginine to cysteine substitutions, splice mutations, and mutations in the C-terminal propeptide have been plotted on the chart. Height of the patients...... progressively deviate from that of normal children: compared to normal WHO charts, the mean length/height is -2.6 SD at birth, -4.2 SD at 5 years, and -5.8 SD in adulthood. The mean adult height (male and female combined) of patients with glycine substitutions in the triple-helical region is 138.2 cm...... with amino-terminal substitutions, while patients with splice mutations are relatively tall. However, there are exceptions and specific mutations can have a strong or a relatively mild negative effect on growth. The observation of significant difference in adult height between affected members of the same...

  11. Investigation on Painting Materials in "Madonna col Bambino e S. Giovannino" by Botticelli

    Science.gov (United States)

    Bersani, D.; Lottici, P. P.; Casoli, A.; Ferrari, M.; Lottini, S.; Cauzzi, D.

    A study on the painting materials (pigments and binders) of the famous painting "Madonna col Bambino e S. Giovannino" by Sandro Botticelli, located in the Museo Civico of Piacenza (Italy), was performed before a recent restoration. The painting materials were investigated by the analysis of five millimetric samples taken in damaged regions. The pigments were determined using the micro-Raman spectroscopy, with the 632.8nm line of a He-Ne laser. Despite the strong fluorescence background, the nature of the ground layer (gypsum and anhydrite) and of most pigments (i.e. goethite, lapis lazuli, white lead) was determined. Gas chromatography coupled with mass spectroscopy (GC/MS) was used to determine the organic binder media, and in particular proteinaceous and lipid materials. Egg and animal glue were found, while no siccative oils were detected.

  12. Research Pilot Milt Thompson in M2-F2 Aircraft Attached to B-52 Mothership

    Science.gov (United States)

    1966-01-01

    Technology) research vehicle, and the DAST (drones for aerodynamic and structural testing). The aircraft supported the development of parachute recovery systems used to recover the space shuttle solid rocket booster casings. It also supported eight orbiter (space shuttle) drag chute tests in 1990. In addition, the B-52 served as the air launch platform for the first six Pegasus space boosters. During its many years of service, the B-52 has undergone several modifications. The first major modification was made by North American Aviation (now part of Boeing) in support of the X-15 program. This involved creating a launch-panel-operator station for monitoring the status of the test vehicle being carried, cutting a large notch in the right inboard wing flap to accommodate the vertical tail of the X-15 aircraft, and installing a wing pylon that enables the B-52 to carry research vehicles and test articles to be air-launched/dropped. Located on the right wing, between the inboard engine pylon and the fuselage, this wing pylon was subjected to extensive testing prior to its use. For each test vehicle the B-52 carried, minor changes were made to the launch-panel operator's station. Built originally by the Boeing Company, the NASA B-52 is powered by eight Pratt & Whitney J57-19 turbojet engines, each of which produce 12,000 pounds of thrust. The aircraft's normal launch speed has been Mach 0.8 (about 530 miles per hour) and its normal drop altitude has been 40,000 to 45,000 feet. It is 156 feet long and has a wing span of 185 feet. The heaviest load it has carried was the No. 2 X-15 aircraft at 53,100 pounds. Project manager for the aircraft is Roy Bryant.

  13. Aberrations of 6q13 mapped to the COL12A1 locus in chondromyxoid fibroma.

    Science.gov (United States)

    Yasuda, Taketoshi; Nishio, Jun; Sumegi, Janos; Kapels, Kayla M; Althof, Pamela A; Sawyer, Jeffrey R; Reith, John D; Bridge, Julia A

    2009-11-01

    Chondromyxoid fibroma, a rare benign bone tumor, may be mistaken for chondrosarcoma. Although cytogenetic studies of chondromyxoid fibroma are few, rearrangements of the long arm of chromosome 6, frequently expressed as an inv(6)(p25q13), are prominent. In this study, conventional cytogenetic analysis of 16 chondromyxoid fibroma samples from 14 patients revealed rearrangements of chromosome 6 in 10 of 11 clonally abnormal specimens. In addition to 6q13 rearrangements, recurrent 6p25 and 6q25 anomalies were detected. Notably, an identical t(6;9)(q25;q22) translocation was identified in two cases, suggesting that it represents a distinct translocation of chondromyxoid fibroma. In an effort to further define the aberrant 6q13 breakpoint and identify the molecular consequences, a fluorescence in situ hybridization (FISH)-based positional cloning strategy on chondromyxoid fibroma abnormal metaphase and interphase cells using a series of bacterial and plasmid artificial chromosome (BAC/PAC) probe combinations spanning a 6.1 Mb region was employed. The breakpoint on 6q13 was located within the COL12A1 gene, a collagen gene purportedly involved in another benign bone tumor, subungual exostosis. The findings of this study expand our knowledge of chromosomal alterations in chondromyxoid fibroma, identify COL12A1 as the likely gene candidate within the recurrent 6q13 breakpoint, and provide an alternative approach for detecting 6q13 anomalies in nondividing cells of chondromyxoid fibroma. The latter could potentially be utilized as an adjunct in diagnostically challenging cases.

  14. 一成骨不全家系的COL1A1基因突变检测%Mutation Detection of COL1A1 Gene in a Pedigree with Osteogenesis Imperfecta

    Institute of Scientific and Technical Information of China (English)

    秦炜; 何隽祥; 施瑾; 邢清和; 高建军; 钱学庆; 刘壮俊; 舒安利; 贺林

    2005-01-01

    成骨不全(Osteogenesis imperfecta,OI)是一种由于Ⅰ型胶原形成障碍,导致骨脆性增强为主要症状的常染色体显性遗传性疾病.临床上主要表现为骨质脆弱、蓝巩膜、耳聋和中等程度的关节畸形等症状.成骨不全基因分别定位于17q21.31-q22和7q22.1,其致病基因分别为COL1A1和COL1A2.对一常染色体显性遗传的成骨不全家系进行连锁分析,在COL1A1遗传位点发现紧密连锁(LOD=9.31;θ=.00).突变检测发现在COL1A1基因第26内含子5′端剪接位点处存在一由GT转换为AT的致病突变,该突变引起的异常剪接是导致成骨不全的致病原因之一.%Osteogenesis imperfecta(OI)is heritable bone fragility,which is inherited as an autosomal dominant trait clinical presentation.Clinical symptom,in general,is dominantly inherited OI with blue sclerae,hearing loss and mild-moderate skeletal deformity.Genetic loci of OI have been mapped to17q21.31-q22 and 7q22.1,in which COL1A1 and COL1A2 are known to be the causal genes.In this work,we performed linkage analysis in a kindred with autosomal dominant hereditary OI.A tight linkage to the markers on chromosome 17q21.31-q22 (maximum two-point lod score:9.31 at θ=.00) was observed.Sequence analysis of COL1A1 revealed a single-base mutation that converted the consensus sequence at the 5′end of intron 26 from GT to AT to form an abnormal splicing site leading to OI.

  15. Frequency of COL4A3/COL4A4 mutations amongst families segregating glomerular microscopic hematuria and evidence for activation of the unfolded protein response. Focal and segmental glomerulosclerosis is a frequent development during ageing.

    Directory of Open Access Journals (Sweden)

    Louiza Papazachariou

    Full Text Available Familial glomerular hematuria(s comprise a genetically heterogeneous group of conditions which include Alport Syndrome (AS and thin basement membrane nephropathy (TBMN. Here we investigated 57 Greek-Cypriot families presenting glomerular microscopic hematuria (GMH, with or without proteinuria or chronic kidney function decline, but excluded classical AS. We specifically searched the COL4A3/A4 genes and identified 8 heterozygous mutations in 16 families (28,1%. Eight non-related families featured the founder mutation COL4A3-p.(G1334E. Renal biopsies from 8 patients showed TBMN and focal segmental glomerulosclerosis (FSGS. Ten patients (11.5% reached end-stage kidney disease (ESKD at ages ranging from 37-69-yo (mean 50,1-yo. Next generation sequencing of the patients who progressed to ESKD failed to reveal a second mutation in any of the COL4A3/A4/A5 genes, supporting that true heterozygosity for COL4A3/A4 mutations predisposes to CRF/ESKD. Although this could be viewed as a milder and late-onset form of autosomal dominant AS, we had no evidence of ultrastructural features or extrarenal manifestations that would justify this diagnosis. Functional studies in cultured podocytes transfected with wild type or mutant COL4A3 chains showed retention of mutant collagens and differential activation of the unfolded protein response (UPR cascade. This signifies the potential role of the UPR cascade in modulating the final phenotype in patients with collagen IV nephropathies.

  16. OsCOL10, a CONSTANS-Like Gene, Functions as a Flowering Time Repressor Downstream of Ghd7 in Rice.

    Science.gov (United States)

    Tan, Junjie; Jin, Mingna; Wang, Jiachang; Wu, Fuqing; Sheng, Peike; Cheng, Zhijun; Wang, Jiulin; Zheng, Xiaoming; Chen, Liping; Wang, Min; Zhu, Shanshan; Guo, Xiuping; Zhang, Xin; Liu, Xuanming; Wang, Chunming; Wang, Haiyang; Wu, Chuanyin; Wan, Jianmin

    2016-04-01

    Flowering time, or heading date, is a critical agronomic trait that determines the cropping season and regional adaptability, and ultimately grain yield in rice. A number of genes involved in photoperiodic flowering have been cloned and their roles in modulating expression of the flowering genes have been characterized to a certain extent. However, much less is known about the pathway in transmitting the day length response signal(s) to induce transition to reproductive growth. Here, we report a constitutive flowering repressor OsCOL10, which encodes a member of the CONSTANS-like (COL) family. Transgenic rice plants overexpressing OsCOL10 (driven by a strong promoter or by fusing it to the activation domain of VP64) showed delayed flowering time under both short and long days.OsCOL10 is affected by the circadian clock and is preferentially expressed in leaf mesophyll cells; it is localized to the nucleus and has transcriptional activation activity. Further studies show that OsCOL10 represses the expression of theFT-like genes RFT1 and Hd3a through Ehd1. Transcripts of OsCOL10 are more abundant in plants carrying a functional Ghd7 allele or overexpressing Ghd7 than in Ghd7-deficient plants, thus placing OsCOL10 downstream of Ghd7.Taking these findings together, we conclude that OsCOL10 functions as a flowering time repressor that links Ghd7 and Ehd1 in rice.

  17. An Analysis of 20 Years of Space Weathering Effects on the Boeing 376 Spacecraft

    Science.gov (United States)

    Frith, James; Anz-Meador, Phillip; Cowardin, Heather; Buckalew, Brent; Lederer, Susan

    2015-01-01

    The Boeing HS-376 spin stabilized spacecraft was a popular design that was launched continuously into geosynchronous orbit starting in 1980, with the last launch occurring in 2003. Over 50 of the HS-376 buses were produced to fulfill a variety of different communication missions for countries all over the world. The design of the bus is easily approximated as a telescoping cylinder that is covered with solar cells and an Earth-facing antenna that is despun at the top of the cylinder. The similarity in design and the number of spacecraft launched over a long period of time make the HS-376 a prime target for studying the effects of solar weathering on solar panels as a function of time. A selection of primarily non-operational HS-376 spacecraft launched over a 20-year time period were observed using the United Kingdom Infrared Telescope on Mauna Kea and multi-band, near-infrared photometry produced. Each spacecraft was observed for an entire night cycling through ZYJHK filters and time-varying colors produced to compare near-infrared color as a function of launch date. The resulting analysis shown here may help in the future to set launch date constraints on the parent object of unidentified debris objects or other unknown spacecraft.

  18. Wide field nulling imager for TPF: the Boeing-SVS hypertelescope concept

    Science.gov (United States)

    Guyon, Olivier

    2003-02-01

    The Terrestrial Planet Finder (TPF) mission is aimed at providing direct images of Earth-like planets orbiting nearby stars and characterizing their atmospheres (low resolution spectroscopy). The BOEING/SVS hypertelescope concept, NRLA (Non-Redundant Linear Array), uses a 35m baseline interferometric rotating array of six 2.3-meter telescopes operating in the infrared (7 to 12 microns) to produce wide field images of exoplanetary systems. The full (u,v) plane coverage of the array offers very good imaging capabilities, which is essential to unambiguously confirm the detection of planets, and also provides an outstanding capability for high resolution/high dynamic range imaging for general astrophysics. Thanks to a novel approach combining pupil densification, phase mask coronagraphy and pupil redilution, this concept combines wide field of view imaging and interferometric nulling of the central star. We first briefly present the techniques used by this concept (phase mask coronagraphy, pupil densification and redilution, aperture synthesis imaging) and demonstrate how they can be used to overcome the limitations commonly encountered by interferometers (low (u,v) plane coverage, small field of view, low dynamical range). A complete computer simulation of the concept has been written and is used to study the performance of the array for exoplanet imaging and spectroscopy. We show that with this concept, detection (S/N=5) of Earth-like planets at 10pc with a 5 microns spectral bandwidth can be achieved in less than an hour (for a 100% quantum efficiency).

  19. Ditching Investigation of a 1/24-Scale Model of the Boeing B-47 Airplane

    Science.gov (United States)

    Fisher, Lloyd J.; Windham, John O.

    1950-01-01

    An investigation of a 1/24-scale dynamically similar model of the Boeing B-47 airplane was made to determine the ditching characteristics and proper ditching technique for the airplane. Various conditions of damage, landing attitude, flap setting, and speed were investigated. The behavior of the model was determined from visual observations, motion-picture records, and time-history deceleration records. The results of the investigation are presented in table form, photographs, and curves. The airplane should be ditched at the lowest speed and highest attitude consistent with adequate control; the flaps should be full down. The airplane will probably make a deep but fairly smooth run. The fuselage bottom will be damaged and partially filled with water; consequently, crew members should be assigned ditching stations near an exit in the upper or forward part of the fuselage. The nacelles may be expected to be torn away from the wing. In calm water the maximum decelerations will be about 3g and the landing run will be about 6 fuselage lengths.

  20. Ditching Investigation of a 1/20-Scale Model of the Boeing Stratocruiser Airplane (C-97)

    Science.gov (United States)

    Fisher, Lloyd J.; Windham, John O.

    1955-01-01

    An investigation of a 1/20-scale dynamically similar model of the Boeing Stratocruiser airplane (C-97) was made to determine the ditching characteristics and proper technique for ditching the airplane. Scale-strength bottoms were used to determine probable damage to the fuselage and the effect of damage on behavior. The behavior of the model was determined from visual observations, motion-picture records, and time-history deceleration records. Data are presented in a table, photographs, and curves. It was concluded that the airplane should be ditched at a medium nose-high landing attitude (near 6 deg) with landing flaps full down. The airplane will probably make a smooth run of medium depth with light spray and may even trim up slightly in the water. The fuselage will probably be damaged and the lower compartment filled with water. In calm water, the maximum longitudinal deceleration will be about 4g and the landing run will be about four fuselage lengths.

  1. Site Environmental Report for Calendar Year 2003 DOE Operations at The Boeing Company, Rocketdyne Propulsion & Power

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Ning [The Boeing Company, Canoga Park, CA (US). Rocketdyne Propulsion and Power; Rutherford, Phil [The Boeing Company, Canoga Park, CA (US). Rocketdyne Propulsion and Power; Samuels, Sandy [The Boeing Company, Canoga Park, CA (US). Rocketdyne Propulsion and Power; Lee, Majelle [The Boeing Company, Canoga Park, CA (US). Rocketdyne Propulsion and Power

    2004-09-30

    This Annual Site Environmental Report (ASER) for 2003 describes the environmental conditions related to work performed for the Department of Energy (DOE) at Area IV of Boeing Rocketdyne’s Santa Susana Field Laboratory (SSFL). In the past, the Energy Technology Engineering Center (ETEC), a government-owned, company-operated test facility, was located in Area IV. The operations at ETEC included development, fabrication, and disassembly of nuclear reactors, reactor fuel, and other radioactive materials. Other activities at ETEC involved the operation of large-scale liquid metal facilities that were used for testing liquid metal fast breeder components. All nuclear work was terminated in 1988; all subsequent radiological work has been directed toward decontamination and decommissioning (D&D) of the former nuclear facilities and their associated sites. Closure of the liquid metal test facilities began in 1996. Results of the radiological monitoring program for the calendar year 2003 continue to indicate that there are no significant releases of radioactive material from Area IV of SSFL. All potential exposure pathways are sampled and/or monitored, including air, soil, surface water, groundwater, direct radiation, transfer of property (land, structures, waste), and recycling.

  2. Site Environmental Report for Calendar Year 2001. DOE Operations at The Boeing Company, Rocketdyne Propulsion & Power

    Energy Technology Data Exchange (ETDEWEB)

    Rutherford, Phil [The Boeing Company, Canoga Park, CA (United States); Samuels, Sandy [The Boeing Company, Canoga Park, CA (United States); Leee, Majelle [The Boeing Company, Canoga Park, CA (United States)

    2002-09-01

    This Annual Site Environmental Report (ASER) for 2001 describes the environmental conditions related to work performed for the Department of Energy (DOE) at Area IV of the Boeing Rocketdyne Santa Susana Field Laboratory (SSFL). In the past, these operations included development, fabrication, and disassembly of nuclear reactors, reactor fuel, and other radioactive materials under the former Atomics International (AI) Division. Other activities included the operation of large-scale liquid metal facilities for testing of liquid metal fast breeder components at the Energy Technology Engineering Center (ETEC), a government-owned, company-operated test facility within Area IV. All nuclear work was terminated in 1988, and subsequently, all radiological work has been directed toward decontamination and decommissioning (D&D) of the previously used nuclear facilities and associated site areas. Closure of the sodium test facilities began in 1996. Results of the radiological monitoring program for the calendar year of 2001 continue to indicate that there are no significant releases of radioactive material from Area IV of SSFL. All potential exposure pathways are sampled and/or monitored, including air, soil, surface water, groundwater, direct radiation, transfer of property (land, structures, waste), and recycling. All radioactive wastes are processed for disposal at DOE disposal sites and other sites approved by DOE and licensed for radioactive waste. Liquid radioactive wastes are not released into the environment and do not constitute an exposure pathway. No structural debris from buildings, released for unrestricted use, was transferred to municipal landfills or recycled in 2001.

  3. Site Environmental Report for Calendar Year 1999. DOE Operations at The Boeing Company, Rocketdyne

    Energy Technology Data Exchange (ETDEWEB)

    None

    2000-09-01

    OAK A271 Site Environmental Report for Calendar Year 1999. DOE Operations at The Boeing Company, Rocketdyne. This Annual Site Environmental Report (ASER) for 1999 describes the environmental conditions related to work performed for the Department of Energy (DOE) at Area IV of the Rocketdyne Santa Susana Field Laboratory (SSFL). In the past, these operations included development, fabrication, and disassembly of nuclear reactors, reactor fuel, and other radioactive materials under the former Atomics International Division. Other activities included the operation of large-scale liquid metal facilities for testing of liquid metal fast breeder components at the Energy Technology Engineering Center (ETEC), a government-owned, company-operated test facility within Area IV. All nuclear work was terminated in 1988, and subsequently, all radiological work has been directed toward decontamination and decommissioning (D&D) of the previously used nuclear facilities and associated site areas. Large-scale D&D activities of the sodium test facilities began in 1996. This Annual Site Environmental Report provides information showing that there are no indications of any potential impact on public health and safety due to the operations conducted at the SSFL. All measures and calculations of off-site conditions demonstrate compliance with applicable regulations, which provide for protection of human health and the environment.

  4. An overview of Boeing flywheel energy storage systems with high-temperature superconducting bearings

    Science.gov (United States)

    Strasik, M.; Hull, J. R.; Mittleider, J. A.; Gonder, J. F.; Johnson, P. E.; McCrary, K. E.; McIver, C. R.

    2010-03-01

    An overview summary of recent Boeing work on high-temperature superconducting (HTS) bearings is presented. A design is presented for a small flywheel energy storage system that is deployable in a field installation. The flywheel is suspended by a HTS bearing whose stator is conduction cooled by connection to a cryocooler. At full speed, the flywheel has 5 kW h of kinetic energy, and it can deliver 3 kW of three-phase 208 V power to an electrical load. The entire system, which includes a containment structure, is compatible with transportation by forklift or crane. Laboratory measurements of the bearing loss are combined with the parasitic loads to estimate the efficiency of the system. Improvements in structural composites are expected to enable the operation of flywheels with very high rim velocities. Small versions of such flywheels will be capable of very high rotational rates and will likely require the low loss inherent in HTS bearings to achieve these speeds. We present results of experiments with small-diameter rotors that use HTS bearings for levitation and rotate in vacuum at kHz rates. Bearing losses are presented as a function of rotor speed.

  5. Stardust is lifted in the launch tower for mating with a Boeing Delta II rocket

    Science.gov (United States)

    1999-01-01

    Workers inside the launch tower at Pad 17-A, Cape Canaveral Air Station, watch as the third stage of a Boeing Delta II rocket is lowered for mating with the second stage below it. The Stardust spacecraft, above it out of sight, is connected to the rocket's third stage. Stardust, targeted for liftoff on Feb. 6, is destined for a close encounter with the comet Wild 2 in January 2004. Using a silicon-based substance called aerogel, Stardust will capture comet particles flying off the nucleus of the comet. The spacecraft also will bring back samples of interstellar dust. These materials consist of ancient pre-solar interstellar grains and other remnants left over from the formation of the solar system. Scientists expect their analysis to provide important insights into the evolution of the sun and planets and possibly into the origin of life itself. The collected samples will return to Earth in a sample return capsule to be jettisoned as Stardust swings by Earth in January 2006.

  6. EHLERS-DANLOS SYNDROME TYPE-IV - PHENOTYPIC CONSEQUENCES OF A SPLICING MUTATION IN ONE COL3A1 ALLELE

    NARCIS (Netherlands)

    SILLENCE, DO; CHIODO, AA; CAMPBELL, PE; COLE, WG

    1991-01-01

    The features of a child with Ehlers-Danlos syndrome type IV (EDS IV) resulting from a mutation in one COL3A1 allele were studied. The child was heterozygous for a G- to A-transition at the splice donor site of intron 41. It resulted in the splicing out of the exon 41 encoded sequence from alpha-1(II

  7. Mutations in the codon for a conserved arginine-1563 in the COL4A5 collagen gene in Alport syndrome

    DEFF Research Database (Denmark)

    Zhou, J; Gregory, M C; Hertz, Jens Michael

    1993-01-01

    We have screened 110 unrelated Alport syndrome kindreds for mutations in the exon 48 region of the COL4A5 collagen gene. Denaturing gradient gel electrophoresis (DGGE) of the PCR-amplified region of exon 48 revealed sequence variants in DNA from affected males and carriers of three unrelated kind...

  8. Asymptomatic parental mosaicism for osteogenesis imperfect associated with a new splice site mutation in COL1A2

    DEFF Research Database (Denmark)

    Frederiksen, Anja Lisbeth; Dunø, Morten; Johnsen, Iben Birgit Gade;

    2016-01-01

    Recurrent lethal perinatal osteogenesis imperfecta may result from asymptomatic parental mosaicism. A previously unreported mutation in COL1A2 leads to recurrent cases of fetal osteogenesis imperfecta Sillence type IIA, which emphasizes the importance of clinical and genetic evaluation of mosaicism...... in asymptomatic parents as verified mosaicism highly increases recurrence risk....

  9. Asymptomatic parental mosaicism for osteogenesis imperfecta associated with a new splice site mutation in COL1A2

    OpenAIRE

    2016-01-01

    Key Clinical Message Recurrent lethal perinatal osteogenesis imperfecta may result from asymptomatic parental mosaicism. A previously unreported mutation in COL1A2 leads to recurrent cases of fetal osteogenesis imperfecta Sillence type IIA, which emphasizes the importance of clinical and genetic evaluation of mosaicism in asymptomatic parents as verified mosaicism highly increases recurrence risk.

  10. Autosomal dominant rhegmatogenous retinal detachment associated with an Arg453Ter mutation in the COL2A1 gene.

    NARCIS (Netherlands)

    Go, S.L.; Maugeri, A.; Mulder, J.J.S.; Driel, M.A. van; Cremers, F.P.M.; Hoyng, C.B.

    2003-01-01

    PURPOSE: To investigate the clinical features and molecular causes of autosomal dominant rhegmatogenous retinal detachment (RRD) in two large families. METHODS: Clinical examination and linkage analysis of both families using markers flanking the COL2A1 gene associated with Stickler syndrome type 1,

  11. Molecular characterization of CONSTANS-Like (COL) genes in banana (Musa acuminata L. AAA Group, cv. Grand Nain).

    Science.gov (United States)

    Chaurasia, Akhilesh Kumar; Patil, Hemant Bhagwan; Azeez, Abdul; Subramaniam, Vadakanthara Ramakrishnan; Krishna, Bal; Sane, Aniruddha Prafullachandra; Sane, Prafullachandra Vishnu

    2016-01-01

    The CONSTANS (CO) family is an important regulator of flowering in photoperiod sensitive plants. But information regarding their role in day neutral plants is limited. We report identification of nine Group I type CONSTANS-like (COL) genes of banana and their characterization for their age dependent, diurnal and tissue-specific expression. Our studies show that the Group I genes are conserved in structure to members in other plants. Expression of these genes shows a distinct circadian regulation with a peak during light period. Developmental stage specific expression reveals high level transcript accumulation of two genes, MaCOL3a and MaCOL3b, well before flowering and until the initiation of flowering. A decrease in their transcript levels after initiation of flowering is followed by an increase in transcription of other members that coincides with the continued development of the inflorescence and fruiting. CO binding cis-elements are observed in at least three FT -like genes in banana suggesting possible CO-FT interactions that might regulate flowering. Distinct tissue specific expression patterns are observed for different family members in mature leaves, apical inflorescence, bracts, fruit skin and fruit pulp suggesting possible roles other than flowering. This is the first exhaustive study of the COL genes belonging to Group I of banana.

  12. Mobilization properties of small ColE1-like plasmids carrying kanamycin resistance gene isolated from Salmonella enterica serotypes

    Science.gov (United States)

    Background: Previously we isolated and characterized various groups of small kanamycin resistance (KanR) ColE1-like plasmids from different serotypes of Salmonella enterica isolates. These plasmids all carried the aph(3)-I gene encoding the aminoglycoside phosphotransferase responsible for the kanam...

  13. Localized and generalized forms of blistering in junctional epidermolysis bullosa due to COL17A1 mutations in the Netherlands

    NARCIS (Netherlands)

    Pasmooij, A. M. G.; Pas, H. H.; Jansen, G. H. L.; Lemmink, H. H.; Jonkman, M. F.

    2007-01-01

    Background Mutations in the gene COL17A1 coding for type XVII collagen cause non-Herlitz junctional epidermolysis bullosa (nH-JEB). Objectives Here we give an overview of the genotype-phenotype correlation in 12 patients from the Netherlands with type XVII collagen-deficient nH-JEB. Patient and meth

  14. 75 FR 38950 - Airworthiness Directives; The Boeing Company Model 727 Airplanes

    Science.gov (United States)

    2010-07-07

    ... Aircraft Certification Office (ACO), 1601 Lind Avenue, SW., Renton, Washington 98057-3356; telephone (425... wing-to-body fairings. The airplane has never had any decals installed in inspection areas since delivery. The existing repairs on the airplane span at least 3 rows above/forward and 3 rows below/aft...

  15. One Novel Frameshift Mutation on Exon 64 of COL7A1 Gene in an Iranian Individual Suffering Recessive Dystrophic Epidermolysis Bullosa.

    Science.gov (United States)

    Khaniani, Mahmoud Shekari; Sohrabi, Nasrin; Derakhshan, Neda Mansoori; Derakhshan, Sima Mansoori

    2015-01-01

    Recessive dystrophic epidermolysis bullosa (RDEB) is an extremely rare subtype of bullous dermatosis caused by the COL7A1 gene mutation. After genomic DNA extraction from the peripheral blood sample of all subjects (3 pedigree members and 3 unrelated control individuals), COL7A1 gene screening was performed by PCR amplification and direct DNA sequencing of all of the coding exons and flanking intronic regions. Genetic analysis of the COL7A1 gene in an affected individual revealed a novel mutation: c.5493delG (p.K1831Nfs*10) in exon 64 of the COL7A1 gene in homozygous state. This mutation was not discovered in 3 unrelated Iranian control individuals. These data suggest that c.5493delG may influence the phenotype of RDEB. The result of this case report contributes to the expanding database on COL7A1 mutations.

  16. Modular Electric Propulsion Test Bed Aircraft Project

    Data.gov (United States)

    National Aeronautics and Space Administration — An all electric aircraft test bed is proposed to provide a dedicated development environment for the rigorous study and advancement of electrically powered aircraft....

  17. Versatile Electric Propulsion Aircraft Testbed Project

    Data.gov (United States)

    National Aeronautics and Space Administration — An all-electric aircraft testbed is proposed to provide a dedicated development environment for the rigorous study and advancement of electrically powered aircraft....

  18. Introduction to unmanned aircraft systems

    CERN Document Server

    Marshall, Douglas M; Hottman, Stephen B; Shappee, Eric; Most, Michael Thomas

    2011-01-01

    Introduction to Unmanned Aircraft Systems is the editors' response to their unsuccessful search for suitable university-level textbooks on this subject. A collection of contributions from top experts, this book applies the depth of their expertise to identify and survey the fundamentals of unmanned aircraft system (UAS) operations. Written from a nonengineering civilian operational perspective, the book starts by detailing the history of UASs and then explores current technology and what is expected for the future. Covering all facets of UAS elements and operation-including an examination of s

  19. Future aircraft networks and schedules

    Science.gov (United States)

    Shu, Yan

    2011-07-01

    Because of the importance of air transportation scheduling, the emergence of small aircraft and the vision of future fuel-efficient aircraft, this thesis has focused on the study of aircraft scheduling and network design involving multiple types of aircraft and flight services. It develops models and solution algorithms for the schedule design problem and analyzes the computational results. First, based on the current development of small aircraft and on-demand flight services, this thesis expands a business model for integrating on-demand flight services with the traditional scheduled flight services. This thesis proposes a three-step approach to the design of aircraft schedules and networks from scratch under the model. In the first step, both a frequency assignment model for scheduled flights that incorporates a passenger path choice model and a frequency assignment model for on-demand flights that incorporates a passenger mode choice model are created. In the second step, a rough fleet assignment model that determines a set of flight legs, each of which is assigned an aircraft type and a rough departure time is constructed. In the third step, a timetable model that determines an exact departure time for each flight leg is developed. Based on the models proposed in the three steps, this thesis creates schedule design instances that involve almost all the major airports and markets in the United States. The instances of the frequency assignment model created in this thesis are large-scale non-convex mixed-integer programming problems, and this dissertation develops an overall network structure and proposes iterative algorithms for solving these instances. The instances of both the rough fleet assignment model and the timetable model created in this thesis are large-scale mixed-integer programming problems, and this dissertation develops subproblem schemes for solving these instances. Based on these solution algorithms, this dissertation also presents

  20. 14 CFR 43.7 - Persons authorized to approve aircraft, airframes, aircraft engines, propellers, appliances, or...

    Science.gov (United States)

    2010-01-01

    ..., airframes, aircraft engines, propellers, appliances, or component parts for return to service after... Administrator, may approve an aircraft, airframe, aircraft engine, propeller, appliance, or component part for..., airframe, aircraft engine, propeller, appliance, or component part for return to service as provided...

  1. 77 FR 1626 - Airworthiness Directives; Various Aircraft Equipped With Rotax Aircraft Engines 912 A Series Engine

    Science.gov (United States)

    2012-01-11

    ... Equipped With Rotax Aircraft Engines 912 A Series Engine AGENCY: Federal Aviation Administration (FAA), DOT... various aircraft equipped with Rotax Aircraft Engines 912 A series engine. This AD results from mandatory... Rotax Aircraft Engines BRP has issued Alert Service Bulletin ASB- 912-059 and ASB-914-042...

  2. 76 FR 31465 - Airworthiness Directives; Various Aircraft Equipped With Rotax Aircraft Engines 912 A Series Engine

    Science.gov (United States)

    2011-06-01

    ... Aircraft Equipped With Rotax Aircraft Engines 912 A Series Engine AGENCY: Federal Aviation Administration...://www.rotax-aircraft-engines.com . You may review copies of the referenced service information at the... by examining the MCAI in the AD docket. Relevant Service Information Rotax Aircraft Engines...

  3. Identification and molecular characterization of two novel mutations in COL1A2 in two Chinese families with osteogenesis imperfecta

    Institute of Scientific and Technical Information of China (English)

    Zhenping Xu; Yulei Li; Xiangyang Zhang; Fanming Zeng; Mingxiong Yuan; Mugen Liu; Qing Kenneth Wang; Jing Yu Liu

    2011-01-01

    Osteogenesis imperfecta (OI, also known as brittle bone disease) is caused mostly by mutations in two type Ⅰ collagen genes, COL1A1 and COL1A2 encoding the pro-α1 (Ⅰ) and pro-α2 (Ⅰ) chains of type Ⅰ collagen, respectively. Two Chinese families with autosomal dominant OI were identified and characterized. Linkage analysis revealed linkage of both families to COL1A2 on chromosome 7q21.3-q22.1. Mutational analysis was carried out using direct DNA sequence analysis. Two novel missense mutations, c.3350A>G and c.3305G>C, were identified in exon 49 of COL1A2 in the two families, respectively. The c.3305G>C mutation resulted in substitution of a glycine residue (G) by an alanine residue (A) at codon 1102 (p.G1102A), which was found to be mutated into serine (S), argine (R), aspartic acid (D), or valine (V) in other families. The c.3350A>G variant may be a de novo mutation resulting in p.Y1117C. Both mutations co-segregated with OI in respective families, and were not found in 100 normal controls. The G1102 and Y1117 residues were evolutionarily highly conserved from zebrafish to humans. Mutational analysis did not identify any mutation in the COX-2 gene (a modifier gene of OI). This study identifies two novel mutations p.G1102A and p.Y1117C that cause OI, significantly expands the spectrum of COL1A2 mutations causing OI, and has a significant implication in prenatal diagnosis of OI.

  4. Novel PAX9 and COL1A2 missense mutations causing tooth agenesis and OI/DGI without skeletal abnormalities.

    Directory of Open Access Journals (Sweden)

    Shih-Kai Wang

    Full Text Available Inherited dentin defects are classified into three types of dentinogenesis imperfecta (DGI and two types of dentin dysplasia (DD. The genetic etiology of DD-I is unknown. Defects in dentin sialophosphoprotein (DSPP cause DD type II and DGI types II and III. DGI type I is the oral manifestation of osteogenesis imperfecta (OI, a systemic disease typically caused by defects in COL1A1 or COL1A2. Mutations in MSX1, PAX9, AXIN2, EDA and WNT10A can cause non-syndromic familial tooth agenesis. In this study a simplex pattern of clinical dentinogenesis imperfecta juxtaposed with a dominant pattern of hypodontia (mild tooth agenesis was evaluated, and available family members were recruited. Mutational analyses of the candidate genes for DGI and hypodontia were performed and the results validated. A spontaneous novel mutation in COL1A2 (c.1171G>A; p.Gly391Ser causing only dentin defects and a novel mutation in PAX9 (c.43T>A; p.Phe15Ile causing hypodontia were identified and correlated with the phenotypic presentations in the family. Bone radiographs of the proband's dominant leg and foot were within normal limits. We conclude that when no DSPP mutation is identified in clinically determined isolated DGI cases, COL1A1 and COL1A2 should be considered as candidate genes. PAX9 mutation p.Phe15Ile within the N-terminal β-hairpin structure of the PAX9 paired domain causes tooth agenesis.

  5. Control del colapso del colágeno: desproteinización Control of the collagen network collapse: collagen remoral

    Directory of Open Access Journals (Sweden)

    E Osario Ruiz

    2004-06-01

    Full Text Available La penetración de la resina y su reacción con los componentes de los tejidos dentales desmineralizados es el mecanismo micromecánico con el cual los materiales restauradores de resina se unen al diente. Los monómeros penetran en la dentina acondicionada y se concentran en la región superficial contribuyendo a la unión. El refuerzo de esta zona con resina se conoce como hibridación, e implica la impregnación de la red de colágeno y el encapsulamiento de los cristales de hidroxiapatita. Han surgido dudas en cuanto a la contribución de la red de colágeno en el ensamblaje de la unión y en la fuerza interfacial, ya que el aumento del grosor de la red de colágeno no aumenta dicha fuerza y la remoción del colágeno con hipoclorito sódico al 5% en solución acuosa da valores similares de fuerza a los que se obtienen cuando la red de colágeno está presenteResin penetration into and its reaction with the components of conditioned, mineralised dental tissues is known to be the fundamental micromechanical mechanism by which restorative materials can be successfully bonded to teeth. Monomers penetrated into conditioned dentin and concentrated in a superficial region of resin-reinforced dentin contributing significantly to the bond. The reinforcement, known as hybridization, involved impregnation, co-mingling and envelopment of collagen bundles and encapsulation of hydroxyapatite crystallites. A doubt raised concerning the quantitative contribution which the collagen network made to interfacial bond strength. lncreasing the thickness of the collagen network did not influence the assembly strength, and removal of the collagen with 5% sodium hypochlorite provided similar values to those recorded when the network was present.

  6. Analyses of Aircraft Responses to Atmospheric Turbulence

    OpenAIRE

    Van Staveren, W.H.J.J.

    2003-01-01

    The response of aircraft to stochastic atmospheric turbulence plays an important role in aircraft-design (load calculations), Flight Control System (FCS) design and flight-simulation (handling qualities research and pilot training). In order to simulate these aircraft responses, an accurate mathematical model is required. Two classical models will be discussed in this thesis, that is the Delft University of Technology (DUT) model and the Four Point Aircraft (FPA) model. Although they are well...

  7. THE AIRPORT DE-ICING OF AIRCRAFTS

    Directory of Open Access Journals (Sweden)

    Robert KONIECZKA

    2015-03-01

    Full Text Available This article provides a summary of the issues involved in de-icing several kinds of aircrafts before flight. The basic risks of an iced aircraft and the factors that can influence its intensity are stated. It discusses the methods for de-icing and protecting against ice formation on small aircrafts, helicopters, and large aircrafts. It also classifies the fluids and other methods used for these de-icing operations, and explains the characteristics and limitations of their use.

  8. Residents' Annoyance Responses to Aircraft Noise Events

    OpenAIRE

    United States, National Aeronautics and Space Administration

    1983-01-01

    In a study conducted in the vicinity of Salt Lake City International Airport, community residents reported their annoyance with individual aircraft flyovers during rating sessions conducted in their homes. Annoyance ratings were obtained at different times of the day. Aircraft noise levels were measured, and other characteristics of the aircraft were noted by trained observers. Metrics commonly used for assessing aircraft noise were compared, but none performed significantly better than A-...

  9. Chemical chaperone treatment reduces intracellular accumulation of mutant collagen IV and ameliorates the cellular phenotype of a COL4A2 mutation that causes haemorrhagic stroke.

    Science.gov (United States)

    Murray, Lydia S; Lu, Yinhui; Taggart, Aislynn; Van Regemorter, Nicole; Vilain, Catheline; Abramowicz, Marc; Kadler, Karl E; Van Agtmael, Tom

    2014-01-15

    Haemorrhagic stroke accounts for ∼20% of stroke cases and porencephaly is a clinical consequence of perinatal cerebral haemorrhaging. Here, we report the identification of a novel dominant G702D mutation in the collagen domain of COL4A2 (collagen IV alpha chain 2) in a family displaying porencephaly with reduced penetrance. COL4A2 is the obligatory protein partner of COL4A1 but in contrast to most COL4A1 mutations, the COL4A2 mutation does not lead to eye or kidney disease. Analysis of dermal biopsies from a patient and his unaffected father, who also carries the mutation, revealed that both display basement membrane (BM) defects. Intriguingly, defective collagen IV incorporation into the dermal BM was observed in the patient only and was associated with endoplasmic reticulum (ER) retention of COL4A2 in primary dermal fibroblasts. This intracellular accumulation led to ER stress, unfolded protein response activation, reduced cell proliferation and increased apoptosis. Interestingly, the absence of ER retention of COL4A2 and ER stress in cells from the unaffected father indicate that accumulation and/or clearance of mutant COL4A2 from the ER may be a critical modifier for disease development. Our analysis also revealed that mutant collagen IV is degraded via the proteasome. Importantly, treatment of patient cells with a chemical chaperone decreased intracellular COL4A2 levels, ER stress and apoptosis, demonstrating that reducing intracellular collagen accumulation can ameliorate the cellular phenotype of COL4A2 mutations. Importantly, these data highlight that manipulation of chaperone levels, intracellular collagen accumulation and ER stress are potential therapeutic options for collagen IV diseases including haemorrhagic stroke.

  10. Molecular evolution and phylogenetic analysis of eight COL superfamily genes in group I related to photoperiodic regulation of flowering time in wild and domesticated cotton (Gossypium) species.

    Science.gov (United States)

    Zhang, Rui; Ding, Jian; Liu, Chunxiao; Cai, Caiping; Zhou, Baoliang; Zhang, Tianzhen; Guo, Wangzhen

    2015-01-01

    Flowering time is an important ecological trait that determines the transition from vegetative to reproductive growth. Flowering time in cotton is controlled by short-day photoperiods, with strict photoperiod sensitivity. As the CO-FT (CONSTANS-FLOWER LOCUS T) module regulates photoperiodic flowering in several plants, we selected eight CONSTANS genes (COL) in group I to detect their expression patterns in long-day and short-day conditions. Further, we individually cloned and sequenced their homologs from 25 different cotton accessions and one outgroup. Finally, we studied their structures, phylogenetic relationship, and molecular evolution in both coding region and three characteristic domains. All the eight COLs in group I show diurnal expression. In the orthologous and homeologous loci, each gene structure in different cotton species is highly conserved, while length variation has occurred due to insertions/deletions in intron and/or exon regions. Six genes, COL2 to COL5, COL7 and COL8, exhibit higher nucleotide diversity in the D-subgenome than in the A-subgenome. The Ks values of 98.37% in all allotetraploid cotton species examined were higher in the A-D and At-Dt comparison than in the A-At and D-Dt comparisons, and the Pearson's correlation coefficient (r) of Ks between A vs. D and At vs. Dt also showed positive, high correlations, with a correlation coefficient of at least 0.797. The nucleotide polymorphism in wild species is significantly higher compared to G. hirsutum and G. barbadense, indicating a genetic bottleneck associated with the domesticated cotton species. Three characteristic domains in eight COLs exhibit different evolutionary rates, with the CCT domain highly conserved, while the B-box and Var domain much more variable in allotetraploid species. Taken together, COL1, COL2 and COL8 endured greater selective pressures during the domestication process. The study improves our understanding of the domestication-related genes/traits during cotton

  11. 中国汉族病理性近视人群的COL9A2基因突变分析%Analysis of COL9A2 gene mutations in a Chinese Han population with pathological myopia

    Institute of Scientific and Technical Information of China (English)

    陈蓉; 龚波; 李倩; 曾光群; 郝(芳); 李宁; 石毅; 张丁丁

    2014-01-01

    目的 对COL9A2基因进行突变分析,探讨中国汉族病理性近视的分子发病机制.方法 选取400例病理性近视患者和400名正常对照,对其中200例患者和200名对照的COL9A2基因全部外显子进行Sanger测序;对检测到的变异位点,应用SNaPshot方法在另外200例患者和200名对照中进行基因分型.结果 通过Sanger测序,在200例病理性近视患者中未检出已报道的D281fs移码突变,但1例患者检测出COL9A2基因第2外显子c.143G>C杂合错义突变,另外1例患者检测出COL9A2基因第17外显子c.884G>A杂合错义突变,在正常对照中未检测到c.143G>C和c.884G>A突变.同时在外显子编码区检测到COL9A2基因rs2228564 SNP位点,其等位基因频率在患者组与正常对照组间的差异无统计学意义(P>0.05).应用SNaPshot方法对另外的200例患者和200名正常对照的这些位点进行基因分型验证,1例患者检测到COL9A2基因第2外显子c.143G>C突变,2例患者检测到COL9A2基因第17外显子c.884G>A突变,rs2228564 SNP位点的等位基因频率在两组间的差异无统计学意义(P>0.05).结论 中国汉族病理性近视与COL9A2基因D281fs移码突变可能无关,COL9A2基因第2外显子c.143G>C突变和第17外显子c.884G>A突变可能与病理性近视的发病有关.%Objective To analyze the mutation of COL9A2 gene and investigate the molecular pathogenesis of pathological myopia in a Han Chinese population.Methods Mutation in the coding region of the COL9A2 gene was screened by Sanger sequencing in 200 subjects with pathological myopia and 200 normal controls.The detected variants were genotyped by SNaPshot method in another 200 myopic cases and 200 normal controls.Results Sanger sequencing has failed to detect the reported D281fs frameshift mutation in the 200 cases.A novel variant,c.143G>C heterozygous missense mutation in exon 2,was identified in a myopic subject,and another novel variant,c.884G

  12. Quantitative Inspection Technologies for Aging Military Aircraft

    Science.gov (United States)

    2013-11-01

    177 Figure 133. Aircraft Mockup With EDM Notches Marked As Red Dots And Numbered In Magnified Photos...178 ix Approved for public release; distribution is unlimited Figure 134. First Test Of The Pantograph Scanner On The Mockup Aircraft...180 Figure 137. CAD Model Of Arc Scanner And Simulated Aircraft Fitting Mockup Panel ..................................... 181 Figure 138

  13. Policy and the evaluation of aircraft noise

    NARCIS (Netherlands)

    Kroesen, M.; Molin, E.J.E.; Van Wee, G.P.

    2010-01-01

    In this paper, we hypothesize and test the ideas that (1) people’s subjectivity in relation to aircraft noise is shaped by the policy discourse, (2) this results in a limited number of frames towards aircraft noise, (3) the frames inform people how to think and feel about aircraft noise and (4) the

  14. 19 CFR 122.37 - Precleared aircraft.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Precleared aircraft. 122.37 Section 122.37 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Landing Requirements § 122.37 Precleared aircraft. (a) Application. This section applies when aircraft carrying...

  15. 19 CFR 122.64 - Other aircraft.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Other aircraft. 122.64 Section 122.64 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Clearance of Aircraft and Permission To Depart § 122.64 Other aircraft. Clearance or permission to depart shall be...

  16. Analyses of Aircraft Responses to Atmospheric Turbulence

    NARCIS (Netherlands)

    Van Staveren, W.H.J.J.

    2003-01-01

    The response of aircraft to stochastic atmospheric turbulence plays an important role in aircraft-design (load calculations), Flight Control System (FCS) design and flight-simulation (handling qualities research and pilot training). In order to simulate these aircraft responses, an accurate mathemat

  17. 14 CFR 91.117 - Aircraft speed.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Aircraft speed. 91.117 Section 91.117... speed. (a) Unless otherwise authorized by the Administrator, no person may operate an aircraft below 10... than the maximum speed prescribed in this section, the aircraft may be operated at that minimum speed....

  18. MATE. Multi Aircraft Training Environment

    DEFF Research Database (Denmark)

    Hauland, G.; Bove, T.; Andersen, Henning Boje

    2002-01-01

    . The cockpit switches and instruments in MATE are computer-generated graphics. The graphics are back projected onto semi-transparent touch screen panels in a hybrid cockpit mock-up. Thus, the MATE is relativelycheap, it is always available, it is reconfigurable (e.g. between types of aircraft...

  19. Aircraft Lightning Electromagnetic Environment Measurement

    Science.gov (United States)

    Ely, Jay J.; Nguyen, Truong X.; Szatkowski, George N.

    2011-01-01

    This paper outlines a NASA project plan for demonstrating a prototype lightning strike measurement system that is suitable for installation onto research aircraft that already operate in thunderstorms. This work builds upon past data from the NASA F106, FAA CV-580, and Transall C-180 flight projects, SAE ARP5412, and the European ILDAS Program. The primary focus is to capture airframe current waveforms during attachment, but may also consider pre and post-attachment current, electric field, and radiated field phenomena. New sensor technologies are being developed for this system, including a fiber-optic Faraday polarization sensor that measures lightning current waveforms from DC to over several Megahertz, and has dynamic range covering hundreds-of-volts to tens-of-thousands-of-volts. A study of the electromagnetic emission spectrum of lightning (including radio wave, microwave, optical, X-Rays and Gamma-Rays), and a compilation of aircraft transfer-function data (including composite aircraft) are included, to aid in the development of other new lightning environment sensors, their placement on-board research aircraft, and triggering of the onboard instrumentation system. The instrumentation system will leverage recent advances in high-speed, high dynamic range, deep memory data acquisition equipment, and fiber-optic interconnect.

  20. Human Response to Aircraft Noise

    NARCIS (Netherlands)

    Kroesen, M.

    2011-01-01

    How can it be that one person is extremely annoyed by the sounds of aircrafts, while his neighbour claims not to be bothered at all? The present thesis attempts to explain this observation by applying a range of quantitative methods to field data gathered among residents living near large airports.