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Sample records for body composition glucose

  1. Body composition in normal subjects: relation to lipid and glucose variables

    DEFF Research Database (Denmark)

    Rosenfalck, A M; Almdal, Thomas Peter; Gotfredsen, A;

    1996-01-01

    OBJECTIVE: To describe sex- and age-dependent values of total and regional body composition as determined by dual-energy X-ray absorptiometry (DXA) in normal subjects, and furthermore to relate body composition measurements to blood lipids, glucose and insulin concentrations. DESIGN: A cross...... subjects. In 87 of the subjects fasting blood glucose, S-insulin and lipid profile were measured. RESULTS: The study population was for each sex divided into five decades for which results on body composition and blood lipids are presented. Body weight increased 2 kg per age decade, representing......-sectional study. SUBJECTS: 173 (84 male and 89 female) healthy subjects, BMI Body composition parameters including data on total bone mineral content (TBMC), total bone mineral density (TBMD), lean body soft tissue mass (LTM), total and regional fat mass (FM) were estimated in all...

  2. Short-Term High-Intensity Interval Training on Body Composition and Blood Glucose in Overweight and Obese Young Women.

    Science.gov (United States)

    Kong, Zhaowei; Sun, Shengyan; Liu, Min; Shi, Qingde

    2016-01-01

    This study was to determine the effects of five-week high-intensity interval training (HIIT) on cardiorespiratory fitness, body composition, blood glucose, and relevant systemic hormones when compared to moderate-intensity continuous training (MICT) in overweight and obese young women. Methods. Eighteen subjects completed 20 sessions of HIIT or MICT for five weeks. HIIT involved 60 × 8 s cycling at ~90% of peak oxygen consumption ([Formula: see text]) interspersed with 12 s recovery, whereas MICT involved 40-minute continuous cycling at 65% of [Formula: see text]. [Formula: see text], body composition, blood glucose, and fasting serum hormones, including leptin, growth hormone, testosterone, cortisol, and fibroblast growth factor 21, were measured before and after training. Results. Both exercise groups achieved significant improvements in [Formula: see text] (+7.9% in HIIT versus +11.7% in MICT) and peak power output (+13.8% in HIIT versus +21.9% in MICT) despite no training effects on body composition or the relevant systemic hormones. Blood glucose tended to be decreased after the intervention (p = 0.062). The rating of perceived exertion in MICT was higher than that in HIIT (p = 0.042). Conclusion. Compared with MICT, short-term HIIT is more time-efficient and is perceived as being easier for improving cardiorespiratory fitness and fasting blood glucose for overweight and obese young women.

  3. Short-Term High-Intensity Interval Training on Body Composition and Blood Glucose in Overweight and Obese Young Women

    Directory of Open Access Journals (Sweden)

    Zhaowei Kong

    2016-01-01

    Full Text Available This study was to determine the effects of five-week high-intensity interval training (HIIT on cardiorespiratory fitness, body composition, blood glucose, and relevant systemic hormones when compared to moderate-intensity continuous training (MICT in overweight and obese young women. Methods. Eighteen subjects completed 20 sessions of HIIT or MICT for five weeks. HIIT involved 60 × 8 s cycling at ~90% of peak oxygen consumption (V˙O2peak interspersed with 12 s recovery, whereas MICT involved 40-minute continuous cycling at 65% of V˙O2peak. V˙O2peak, body composition, blood glucose, and fasting serum hormones, including leptin, growth hormone, testosterone, cortisol, and fibroblast growth factor 21, were measured before and after training. Results. Both exercise groups achieved significant improvements in V˙O2peak (+7.9% in HIIT versus +11.7% in MICT and peak power output (+13.8% in HIIT versus +21.9% in MICT despite no training effects on body composition or the relevant systemic hormones. Blood glucose tended to be decreased after the intervention (p=0.062. The rating of perceived exertion in MICT was higher than that in HIIT (p=0.042. Conclusion. Compared with MICT, short-term HIIT is more time-efficient and is perceived as being easier for improving cardiorespiratory fitness and fasting blood glucose for overweight and obese young women.

  4. Short-Term High-Intensity Interval Training on Body Composition and Blood Glucose in Overweight and Obese Young Women

    Science.gov (United States)

    Kong, Zhaowei; Sun, Shengyan; Liu, Min

    2016-01-01

    This study was to determine the effects of five-week high-intensity interval training (HIIT) on cardiorespiratory fitness, body composition, blood glucose, and relevant systemic hormones when compared to moderate-intensity continuous training (MICT) in overweight and obese young women. Methods. Eighteen subjects completed 20 sessions of HIIT or MICT for five weeks. HIIT involved 60 × 8 s cycling at ~90% of peak oxygen consumption (V˙O2peak) interspersed with 12 s recovery, whereas MICT involved 40-minute continuous cycling at 65% of V˙O2peak. V˙O2peak, body composition, blood glucose, and fasting serum hormones, including leptin, growth hormone, testosterone, cortisol, and fibroblast growth factor 21, were measured before and after training. Results. Both exercise groups achieved significant improvements in V˙O2peak (+7.9% in HIIT versus +11.7% in MICT) and peak power output (+13.8% in HIIT versus +21.9% in MICT) despite no training effects on body composition or the relevant systemic hormones. Blood glucose tended to be decreased after the intervention (p = 0.062). The rating of perceived exertion in MICT was higher than that in HIIT (p = 0.042). Conclusion. Compared with MICT, short-term HIIT is more time-efficient and is perceived as being easier for improving cardiorespiratory fitness and fasting blood glucose for overweight and obese young women.

  5. Activin B regulates islet composition and islet mass but not whole body glucose homeostasis or insulin sensitivity

    Science.gov (United States)

    Bonomi, Lara; Brown, Melissa; Ungerleider, Nathan; Muse, Meghan; Matzuk, Martin M.

    2012-01-01

    Based on the phenotype of the activin-like kinase-7 (ALK7)-null mouse, activins A and B have been proposed to play distinct roles in regulating pancreatic islet function and glucose homeostasis, with activin A acting to enhance islet function and insulin release while activin B antagonizes these actions. We therefore hypothesized that islets from activin B-null (BBKO) mice would have enhanced glucose-stimulated insulin secretion. In addition, we hypothesized that this enhanced islet function would translate into increased whole body glucose tolerance. We tested these hypotheses by analyzing glucose homeostasis, insulin secretion, and islet function in BBKO mice. No differences were observed in fasting glucose or insulin levels, glucose tolerance, or insulin sensitivity compared with weight-matched young or older males. Similarly, there were no significant differences in insulin secretion comparing islets from WT or BBKO males at either age. However, BBKO islets were more sensitive to activin A, myostatin (MSTN), and follistatin (FST) treatments, so that activin A and FST inhibited and MSTN enhanced glucose stimulated insulin secretion. While mean islet area and the distribution of islet areas were not different between the genotypes, islet mass, islet number, and the proportion of α-cells/islet were significantly reduced in BBKO islets. These results indicate that activin B does not antagonize activin A to influence whole body glucose homeostasis or β-cell function but does influence islet mass and proportion of α-cells/islet. Therefore, loss of activin B signaling alone does not account for the ALK7-null phenotype, but activin B may have important roles in modulating islet mass, islet number, and the cellular composition of islets. PMID:22739106

  6. Insulin Resistance in Nondiabetic Peritoneal Dialysis Patients: Associations with Body Composition, Peritoneal Transport, and Peritoneal Glucose Absorption.

    Science.gov (United States)

    Bernardo, Ana Paula; Oliveira, Jose C; Santos, Olivia; Carvalho, Maria J; Cabrita, Antonio; Rodrigues, Anabela

    2015-12-07

    Insulin resistance has been associated with cardiovascular disease in peritoneal dialysis patients. Few studies have addressed the impact of fast transport status or dialysis prescription on insulin resistance. The aim of this study was to test whether insulin resistance is associated with obesity parameters, peritoneal transport rate, and glucose absorption. Insulin resistance was evaluated with homeostasis model assessment method (HOMA-IR), additionally corrected by adiponectin (HOMA-AD). Enrolled patients were prevalent nondiabetics attending at Santo António Hospital Peritoneal Dialysis Unit, who were free of hospitalization or infectious events in the previous 3 months (51 patients aged 50.4 ± 15.9 years, 59% women). Leptin, adiponectin, insulin-like growth factor-binding protein 1 (IGFBP-1), and daily glucose absorption were also measured. Lean tissue index, fat tissue index (FTI), and relative fat mass (rel.FM) were assessed using multifrequency bioimpedance. Patients were categorized according to dialysate to plasma creatinine ratio at 4 hours, 3.86% peritoneal equilibration test, and obesity parameters. Obesity was present in 49% of patients according to rel.FM. HOMA-IR correlated better with FTI than with body mass index. Significant correlations were found in obese, but not in nonobese patients, between HOMA-IR and leptin, leptin/adiponectin ratio (LAR), and IGFBP-1. HOMA-IR correlated with HOMA-AD, but did not correlate with glucose absorption or transport rate. There were no significant differences in insulin resistance indices, glucose absorption, and body composition parameters between fast and nonfast transporters. A total of 18 patients (35.3%) who had insulin resistance presented with higher LAR and rel.FM (7.3 [12.3, interquartile range] versus 0.7 [1.4, interquartile range], Pinsulin resistance. FTI and LAR were independent correlates of HOMA-IR in multivariate analysis adjusted for glucose absorption and small-solute transport (r=0

  7. Variation in sequence and expression of the avian FTO, and association with glucose metabolism, body weight, fatness and body composition in chickens.

    Science.gov (United States)

    Jia, X; Nie, Q; Lamont, S J; Zhang, X

    2012-08-01

    The fat mass and obesity-associated gene (FTO), a crucial gene that affects human obesity and metabolism, has been widely studied in mammals but remains poorly characterized in birds. We aimed to identify variant FTO transcripts in domestic avian species, and to characterize the expression and biological functions of FTO in chickens. Variant FTO transcripts and their expression in birds were investigated using RACE and real-time quantitative reverse transcriptase-PCR technology. The effects of FTO on glucose metabolism, growth and body composition were determined by fasting and various diet treatments, as well as association analysis in a F₂ resource population. The function of cFTO1 was further studied by overexpression in chick embryo fibroblast (CEF) cells. Variant FTO transcripts were identified in chicken (cFTO1 to cFTO4), duck (dFTO1, dFTO2 and dFTO4) and goose (gFTO1, gFTO2 and gFTO5). In the chicken, the complete transcript (cFTO1) was predominantly expressed in the leg muscle, pituitary, hypothalamus and cerebellum. Fasting increased both cFTO1 and PGC1α gene expression in the cerebrum, liver, breast muscle and subcutaneous fat, but decreased expression in the pituitary and anterior hypothalamus. In all tested tissues in chickens, a high-glucose diet markedly increased cFTO1 and PGC1α expression. Feeding a high-fat diet increased both cFTO1 and PGC1α expression, except in the pituitary. Overexpression of cFTO1 in CEF cells significantly increased the expression of PGC1α (2.5-fold), STAT3 (2.2-fold) and HL (1.5-fold), a cluster of genes related to energy metabolism. A total of 65 single nucleotide polymorphisms (SNPs) were identified in chicken FTO, and 18 tested SNPs were significantly associated with traits of body weight, body composition and fatness. These data collectively indicate that FTO is related to glucose metabolism, body weight, fatness and body composition in birds, thus expanding knowledge of FTO function to non-mammalian species.

  8. Over-the-counter analgesics normalize blood glucose and body composition in mice fed a high fat diet.

    Science.gov (United States)

    Kendig, Eric L; Schneider, Scott N; Clegg, Deborah J; Genter, Mary Beth; Shertzer, Howard G

    2008-07-15

    Type 2 diabetes (noninsulin-dependent diabetes mellitus) develops from a pre-diabetic condition that is characterized by insulin resistance and glucose intolerance, and is exacerbated by obesity. In this study, we compared the ability of over-the-counter analgesic drugs (OTCAD) [acetaminophen (APAP); ibuprofen (IBU); naproxen (NAP); aspirin (ASA)], to protect against the development of a pre-diabetic state in mice fed a high fat diet. After 10 weeks on the high fat diet, mice had normal fasting blood glucose (FBG) levels, but exhibited impaired glucose tolerance. Treatment with 20 mg OTCADs/kg body weight improved glucose tolerance, with the order of efficacy, APAP=ASA>IBU, while NAP proved ineffective. Mice fed the high fat diet also exhibited increases in weight gain associated with an increase in body fat. OTCADs prevented in part this increase in body fat, in the order of efficacy, APAP=IBU>NAP=ASA. In isolated liver mitochondria, OTCADs inhibited succinate-dependent H2O2 production, while in white adipose tissue, APAP inhibited NADPH-oxidase mediated H2O2 production and lipid peroxidation. Thus, OTCADs diminish pro-oxidant processes that might otherwise exacerbate inflammation and a pre-diabetic state. We conclude that OTCADs, especially APAP and IBU, may be valuable tools to delay or prevent the development of type 2 diabetes from a pre-diabetic condition.

  9. Chronic maternal vitamin B12 restriction induced changes in body composition & glucose metabolism in the Wistar rat offspring are partly correctable by rehabilitation.

    Directory of Open Access Journals (Sweden)

    Kalle Anand Kumar

    Full Text Available Maternal under-nutrition increases the risk of developing metabolic diseases. We studied the effects of chronic maternal dietary vitamin B12 restriction on lean body mass (LBM, fat free mass (FFM, muscle function, glucose tolerance and metabolism in Wistar rat offspring. Prevention/reversibility of changes by rehabilitating restricted mothers from conception or parturition and their offspring from weaning was assessed. Female weaning Wistar rats (n = 30 were fed ad libitum for 12 weeks, a control diet (n = 6 or the same with 40% restriction of vitamin B12 (B12R (n = 24; after confirming deficiency, were mated with control males. Six each of pregnant B12R dams were rehabilitated from conception and parturition and their offspring weaned to control diet. While offspring of six B12R dams were weaned to control diet, those of the remaining six B12R dams continued on B12R diet. Biochemical parameters and body composition were determined in dams before mating and in male offspring at 3, 6, 9 and 12 months of their age. Dietary vitamin B12 restriction increased body weight but decreased LBM% and FFM% but not the percent of tissue associated fat (TAF% in dams. Maternal B12R decreased LBM% and FFM% in the male offspring, but their TAF%, basal and insulin stimulated glucose uptake by diaphragm were unaltered. At 12 months age, B12R offspring had higher (than controls fasting plasma glucose, insulin, HOMA-IR and impaired glucose tolerance. Their hepatic gluconeogenic enzyme activities were increased. B12R offspring had increased oxidative stress and decreased antioxidant status. Changes in body composition, glucose metabolism and stress were reversed by rehabilitating B12R dams from conception, whereas rehabilitation from parturition and weaning corrected them partially, highlighting the importance of vitamin B12 during pregnancy and lactation on growth, muscle development, glucose tolerance and metabolism in the offspring.

  10. Chronic maternal vitamin B12 restriction induced changes in body composition & glucose metabolism in the Wistar rat offspring are partly correctable by rehabilitation.

    Science.gov (United States)

    Kumar, Kalle Anand; Lalitha, Anumula; Reddy, Umakar; Chandak, Giriraj Ratan; Sengupta, Shantanu; Raghunath, Manchala

    2014-01-01

    Maternal under-nutrition increases the risk of developing metabolic diseases. We studied the effects of chronic maternal dietary vitamin B12 restriction on lean body mass (LBM), fat free mass (FFM), muscle function, glucose tolerance and metabolism in Wistar rat offspring. Prevention/reversibility of changes by rehabilitating restricted mothers from conception or parturition and their offspring from weaning was assessed. Female weaning Wistar rats (n = 30) were fed ad libitum for 12 weeks, a control diet (n = 6) or the same with 40% restriction of vitamin B12 (B12R) (n = 24); after confirming deficiency, were mated with control males. Six each of pregnant B12R dams were rehabilitated from conception and parturition and their offspring weaned to control diet. While offspring of six B12R dams were weaned to control diet, those of the remaining six B12R dams continued on B12R diet. Biochemical parameters and body composition were determined in dams before mating and in male offspring at 3, 6, 9 and 12 months of their age. Dietary vitamin B12 restriction increased body weight but decreased LBM% and FFM% but not the percent of tissue associated fat (TAF%) in dams. Maternal B12R decreased LBM% and FFM% in the male offspring, but their TAF%, basal and insulin stimulated glucose uptake by diaphragm were unaltered. At 12 months age, B12R offspring had higher (than controls) fasting plasma glucose, insulin, HOMA-IR and impaired glucose tolerance. Their hepatic gluconeogenic enzyme activities were increased. B12R offspring had increased oxidative stress and decreased antioxidant status. Changes in body composition, glucose metabolism and stress were reversed by rehabilitating B12R dams from conception, whereas rehabilitation from parturition and weaning corrected them partially, highlighting the importance of vitamin B12 during pregnancy and lactation on growth, muscle development, glucose tolerance and metabolism in the offspring.

  11. Tamoxifen affects glucose and lipid metabolism parameters, causes browning of subcutaneous adipose tissue and transient body composition changes in C57BL/6NTac mice.

    Science.gov (United States)

    Hesselbarth, Nico; Pettinelli, Chiara; Gericke, Martin; Berger, Claudia; Kunath, Anne; Stumvoll, Michael; Blüher, Matthias; Klöting, Nora

    2015-08-28

    Tamoxifen is a selective estrogen receptor (ER) modulator which is widely used to generate inducible conditional transgenic mouse models. Activation of ER signaling plays an important role in the regulation of adipose tissue (AT) metabolism. We therefore tested the hypothesis that tamoxifen administration causes changes in AT biology in vivo. 12 weeks old male C57BL/6NTac mice were treated with either tamoxifen (n = 18) or vehicle (n = 18) for 5 consecutive days. Tamoxifen treatment effects on body composition, energy homeostasis, parameters of AT biology, glucose and lipid metabolism were investigated up to an age of 18 weeks. We found that tamoxifen treatment causes: I) significantly increased HbA1c, triglyceride and free fatty acid serum concentrations (p body composition changes. Tamoxifen may induce changes in body composition, whole body glucose and lipid metabolism and has significant effects on AT biology, which need to be considered when using Tamoxifen as a tool to induce conditional transgenic mouse models. Our data further suggest that tamoxifen-treated wildtype mice should be characterized in parallel to experimental transgenic models to control for tamoxifen administration effects.

  12. Tamoxifen affects glucose and lipid metabolism parameters, causes browning of subcutaneous adipose tissue and transient body composition changes in C57BL/6NTac mice

    Energy Technology Data Exchange (ETDEWEB)

    Hesselbarth, Nico; Pettinelli, Chiara [Department of Medicine, University of Leipzig, D-04103 Leipzig (Germany); Gericke, Martin [Institute of Anatomy, University of Leipzig, D-04103 Leipzig (Germany); Berger, Claudia [IFB Adiposity Disease, Core Unit Animal Models, University of Leipzig, D-04103 Leipzig (Germany); Kunath, Anne [German Center for Diabetes Research (DZD), Leipzig (Germany); Stumvoll, Michael; Blüher, Matthias [Department of Medicine, University of Leipzig, D-04103 Leipzig (Germany); Klöting, Nora, E-mail: nora.kloeting@medizin.uni-leipzig.de [IFB Adiposity Disease, Core Unit Animal Models, University of Leipzig, D-04103 Leipzig (Germany)

    2015-08-28

    Tamoxifen is a selective estrogen receptor (ER) modulator which is widely used to generate inducible conditional transgenic mouse models. Activation of ER signaling plays an important role in the regulation of adipose tissue (AT) metabolism. We therefore tested the hypothesis that tamoxifen administration causes changes in AT biology in vivo. 12 weeks old male C57BL/6NTac mice were treated with either tamoxifen (n = 18) or vehicle (n = 18) for 5 consecutive days. Tamoxifen treatment effects on body composition, energy homeostasis, parameters of AT biology, glucose and lipid metabolism were investigated up to an age of 18 weeks. We found that tamoxifen treatment causes: I) significantly increased HbA{sub 1c}, triglyceride and free fatty acid serum concentrations (p < 0.01), II) browning of subcutaneous AT and increased UCP-1 expression, III) increased AT proliferation marker Ki67 mRNA expression, IV) changes in adipocyte size distribution, and V) transient body composition changes. Tamoxifen may induce changes in body composition, whole body glucose and lipid metabolism and has significant effects on AT biology, which need to be considered when using Tamoxifen as a tool to induce conditional transgenic mouse models. Our data further suggest that tamoxifen-treated wildtype mice should be characterized in parallel to experimental transgenic models to control for tamoxifen administration effects. - Highlights: • Tamoxifen treatment causes significantly increased HbA{sub 1c}, triglyceride and free fatty acid serum concentrations. • Tamoxifen induces browning of subcutaneous AT and increased UCP-1 expression. • Tamoxifen changes adipocyte size distribution, and transient body composition.

  13. The effect of 30 months of low-dose replacement therapy with recombinant human growth hormone (rhGH) on insulin and C-peptide kinetics, insulin secretion, insulin sensitivity, glucose effectiveness, and body composition in GH-deficient adults

    DEFF Research Database (Denmark)

    Rosenfalck, A M; Maghsoudi, S; Fisker, S;

    2000-01-01

    (frequently sampled iv glucose tolerance test) glucose tolerance test, and body composition was estimated by dual-energy x-ray absorptiometry. Treatment with rhGH induced persistent favorable changes in body composition, with a 10% increase in lean body mass (P ...The aim of the present study was to evaluate the long-term (30 months) metabolic effects of recombinant human GH (rhGH) given in a mean dose of 6.7 microg/kg x day (= 1.6 IU/day), in 11 patients with adult GH deficiency. Glucose metabolism was evaluated by an oral glucose tolerance test and an iv...... in glucose tolerance, beta-cell response was still inappropriate. Our conclusion is that long-term rhGH-replacement therapy in GH deficiency adults induced a significant deterioration in glucose tolerance, profound changes in kinetics of C-peptide, and insulin and prehepatic insulin secretion, despite...

  14. Zooplankton body composition

    OpenAIRE

    Kiørboe, Thomas

    2013-01-01

    I compiled literature on zooplankton body composition, from protozoans to gelatinous plankton, and report allometric relations and average body composition. Zooplankton segregate into gelatinous and non-gelatinousforms, with few intermediate taxa (chaetognaths, polychaetes, and pteropods). In most groups body composition is size independent. Exceptions are protozoans, chaetognaths, and pteropods, where larger individuals becomeincreasingly watery. I speculate about the dichotomy in body compo...

  15. Zooplankton body composition

    DEFF Research Database (Denmark)

    Kiørboe, Thomas

    2013-01-01

    I compiled literature on zooplankton body composition, from protozoans to gelatinous plankton, and report allometric relations and average body composition. Zooplankton segregate into gelatinous and non-gelatinous forms, with few intermediate taxa (chaetognaths, polychaetes, and pteropods). In most...

  16. Glucocorticoid receptor gene haplotypes are not associated with birth anthropometry, blood pressure, glucose and insulin concentrations, and body composition in subjects born small for gestational age.

    Science.gov (United States)

    Manenschijn, L; van den Akker, E L T; Ester, W A; Leunissen, R W J; Willemsen, R H; van Rossum, E F C; Koper, J W; Lamberts, S W J; Hokken-Koelega, A C S

    2010-12-01

    Smaller size at birth has been associated with an increased risk of metabolic and cardiovascular disorders in adult life. Fetal programming of the hypothalamic-pituitary-adrenal axis has been suggested as a possible explanation. Fetal glucocorticoid (GC) overexposure has effects that suggest a role of GCs in this programming. The effects of GCs are mediated through the GC receptor (GR or NR3C1). Several functional polymorphisms have been described, which are associated with relative GC resistance or hypersensitivity. Our aim is to compare frequencies of GR haplotypes, characterized by the R23K, N363S, Bcl1, or 9β polymorphisms, in subjects born small for gestational age (SGA) and associate birth anthropometry data, response to GH treatment, blood pressure, glucose and insulin concentrations, and body composition with these haplotypes. In total, 418 SGA subjects and 697 healthy controls were enrolled in this study. Methods Anthropometry data were obtained, as well as blood samples to determine fasting glucose and insulin concentrations. Dual energy X-ray absorptiometry scans were used to measure the amount of fat and lean mass. No differences were found between GR haplotype frequencies in SGA children compared with healthy controls. No associations were found between GR haplotypes and birth length and birth weight, growth response during GH treatment, blood pressure, glucose and insulin concentrations, and body composition. GR haplotypes and their effect on GC sensitivity do not seem to play a significant role in GH-induced catch-up growth and the risk factors of developing metabolic and cardiovascular disorders in adult life of SGA children.

  17. Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet.

    Science.gov (United States)

    Chen, Nora; Bezzina, Rebecca; Hinch, Edward; Lewandowski, Paul A; Cameron-Smith, David; Mathai, Michael L; Jois, Markandeya; Sinclair, Andrew J; Begg, Denovan P; Wark, John D; Weisinger, Harrison S; Weisinger, Richard S

    2009-11-01

    The mechanisms of how tea and epigallocatechin-3-gallate (EGCG) lower body fat are not completely understood. This study investigated long-term administration of green tea (GT), black tea (BT), or isolated EGCG (1 mg/kg per day) on body composition, glucose tolerance, and gene expression related to energy metabolism and lipid homeostasis; it was hypothesized that all treatments would improve the indicators of metabolic syndrome. Rats were fed a 15% fat diet for 6 months from 4 weeks of age and were supplied GT, BT, EGCG, or water. GT and BT reduced body fat, whereas GT and EGCG increased lean mass. At 16 weeks GT, BT, and EGCG improved glucose tolerance. In the liver, GT and BT increased the expression of genes involved in fatty acid synthesis (SREBP-1c, FAS, MCD, ACC) and oxidation (PPAR-alpha, CPT-1, ACO); however, EGCG had no effect. In perirenal fat, genes that mediate adipocyte differentiation were suppressed by GT (Pref-1, C/EBP-beta, and PPAR-gamma) and BT (C/EBP-beta), while decreasing LPL, HSL, and UCP-2 expression; EGCG increased expression of UCP-2 and PPAR-gamma genes. Liver triacylglycerol content was unchanged. The results suggest that GT and BT suppressed adipocyte differentiation and fatty acid uptake into adipose tissue, while increasing fat synthesis and oxidation by the liver, without inducing hepatic fat accumulation. In contrast, EGCG increased markers of thermogenesis and differentiation in adipose tissue, while having no effect on liver or muscle tissues at this dose. These results show novel and separate mechanisms by which tea and EGCG may improve glucose tolerance and support a role for these compounds in obesity prevention.

  18. Relationships between abdominal fat distribution assessed by computer tomography, body composition, serum lipids, plasma glucose and cardiorespiratory functions in obese children

    Energy Technology Data Exchange (ETDEWEB)

    Torigoe, Katsumi; Numata, Osamu; Sudo, Shouji; Matsunaga, Masamichi; Kyo, Shigeharu; Yoshida, Hiroshi; Onozuka, Yutaka; Imai, Chihaya [Nagaoka Red Cross Hospital, Niigata (Japan)

    1995-03-01

    Visceral abdominal fat to subcutaneous abdominal fat ratio (V/S ratio) is a predictor for cardiac disease, metabolic disease, and hypertension in obese adults. This study determined the histopathological value of V/S ratio in obese children using computed tomography (CT). The subjects were 37 boys and 26 girls with overweight by more than 20%, whose ages ranged from 3 to 16 years. Although the percentage of standard body weight (SBW), percentage of body fat (BF), and body mass index (BMI) were correlated with each other, there was no correlation between the V/S ratio and the three predictors. Thus, the V/S ratio is completely different from the other obesity predictors in children. The V/S ratio in children of 20% or more overweight of SBW was 0.28{+-}0.11. The V/S ratio of 0.4, used as an obesity predictor in adults, was not considered suitable in the case of children. Liver function, serum lipid levels, and serum glucose correlated with the percentage of SBW, BMI, and the percentage of BF, but not correlated with the V/S ratio. According to the V/S ratio, the patients were divided into the group of V/S ratio of less than 0.28 (group I, n=34) and the group of V/S ratio of 0.28 or more (group II, n=27). There was no significant difference in age, percentage of SBW, BMI, and percentage of BF. Triglyceride was significantly higher in group II than group I, but there was no significant difference in plasma glucose and other lipids, body composition, blood pressure or respiratory function. Of note, the V/S ratio of 0.4 or more was seen in only 9 of the 61 children (14.7%). These findings suggest that the V/S ratio for children is a predictor different from that in the case of adults. (N.K.).

  19. Comparison of 5% versus 15% sucrose intakes as part of a eucaloric diet in overweight and obese subjects: effects on insulin sensitivity, glucose metabolism, vascular compliance, body composition and lipid profile. A randomised controlled trial.

    Science.gov (United States)

    Lewis, Anthony S; McCourt, Hannah J; Ennis, Cieran N; Bell, Patrick M; Courtney, C Hamish; McKinley, Michelle C; Young, Ian S; Hunter, Steven J

    2013-05-01

    The effect of dietary sucrose on insulin resistance and the pathogenesis of diabetes and vascular disease is unclear. We assessed the effect of 5% versus 15% sucrose intakes as part of a weight maintaining, eucaloric diet in overweight/obese subjects. Thirteen subjects took part in a randomised controlled crossover study (M:F 9:4, median age 46 years, range 37-56 years, BMI 31.7±0.9 kg/m(2)). Subjects completed two 6 week dietary periods separated by 4 week washout. Diets were designed to have identical macronutrient profile. Insulin action was assessed using a two-step hyperinsulinaemic euglycaemic clamp; glucose tolerance, vascular compliance, body composition and lipid profiles were also assessed. There was no change in weight or body composition between diets. There was no difference in peripheral glucose utilization or suppression of endogenous glucose production. Fasting glucose was significantly lower after the 5% diet. There was no demonstrated effect on lipid profiles, blood pressure or vascular compliance. A low-sucrose diet had no beneficial effect on insulin resistance as measured by the euglycaemic glucose clamp. However, reductions in fasting glucose, one hour insulin and insulin area under the curve with the low sucrose diet on glucose tolerance testing may indicate a beneficial effect and further work is required to determine if this is the case. Clinical Trial Registration number ISRCTN50808730. Copyright © 2013 Elsevier Inc. All rights reserved.

  20. [Acute-phase serum proteins and adipocytokines in women with type 2 diabetes mellitus: Relationships with body composition and blood glucose fluctuations].

    Science.gov (United States)

    Klimontov, V V; Tyan, N V; Fazullina, O N; Myakina, N E; Orlov, N B; Konenkov, V I

    To estimate the relationships between the serum concentrations of acute-phase proteins (APPs) and adipocytokines, body composition (BC), and blood glucose (BG) fluctuations in women with type 2 diabetes mellitus (T2DM). A total of 165 women with T2DM and 22 with a normal body mass index (BMI) at the age of 40 to 70 years were examined. The concentrations of high-sensitivity C-reactive protein (hs-CRP) and acid α1-glycoprotein (α1-AGP) were determined by ELISA. The levels of interleukins 6, 8, and 18 (IL-6, IL-8, IL-18), tumor necrosis factor-α (TNF-α), and plasminogen activator inhibitor type 1 (PAI-1) were measured by a multiplex analysis. Dual energy X-ray absorptiometry was used to estimate BC parameters. BG fluctuations were estimated via continuous glucose monitoring. The levels of hs-CRP, α1-AGP, IL-6, IL-8, IL-18, TNF-α, and PAI-1 were significantly higher in the obese women with T2DM than those in the control group. In the diabetic normal weight women, only hs-CRP, α1-AGP, and IL-8 concentrations exceeded those in the controls. The level of hs-CRP (other than α1-AGP) correlated positively with BMI, the mass of adipose tissue, body trunk (android), and gynoid fats. A multivariate regression analysis showed that adipose tissue mass and trunk fat proportion were independent predictors of hs-CRP levels. The concentrations of IL-6, IL-8, IL-18, PAI-1, and TNF-α correlated positively with waist-to-hip ratio, but demonstrated no associations with BMI and BC. Only the serum α1-AGP level showed a positive association with mean BG and its variability parameters. In the women with T2DM, the serum concentrations of APPs and adipocytokines correlate differently with the mass of adipose tissue, its distribution, and BG fluctuations. The findings indicate the multifactorial genesis of chronic inflammation in these patients.

  1. The effect of a fibre supplement compared to a healthy diet on body composition, lipids, glucose, insulin and other metabolic syndrome risk factors in overweight and obese individuals.

    Science.gov (United States)

    Pal, Sebely; Khossousi, Alireza; Binns, Colin; Dhaliwal, Satvinder; Ellis, Vanessa

    2011-01-01

    Optimum levels and types of dietary fibre that provide the greatest beneficial effects on metabolic syndrome risk factors in overweight and obese individuals have yet to be determined in clinical trials. The present parallel design study compared the effects of fibre intake from a healthy diet v. a fibre supplement (psyllium) or a healthy diet plus fibre supplement on fasting lipids, glucose, insulin and body composition. Overweight/obese adults were randomised to either control (with placebo), fibre supplement (FIB), healthy eating plus placebo (HLT) or healthy eating plus fibre supplement (HLT-FIB). There was a significant increase in fibre intake in HLT-FIB, HLT and FIB groups up to 59, 31 and 55 g, respectively, at 12 weeks when compared to control (20 g). Weight, BMI and % total body fat were significantly reduced in FIB and HLT-FIB groups, with weight and BMI significantly reduced in the HLT group compared with control at 12 weeks. HLT-FIB and HLT groups had significant reductions in TAG and insulin compared with control at 6 and 12 weeks, and in insulin compared with the FIB group at 12 weeks. The HLT-FIB, HLT and FIB groups all had significant reductions in total cholesterol and LDL-cholesterol compared with control after 6 and 12 weeks. The present study demonstrated that simply adding psyllium fibre supplementation to a normal diet was sufficient to obtain beneficial effects in risk factors. However, a high-fibre diet consisting of a psyllium supplement plus fibre from a healthy diet provided the greatest improvements in metabolic syndrome risk factors.

  2. 成人身体成分与血脂、血糖关系的探讨%Analysis of the relationship between body composition and fasting serum lipids, fasting blood glucose in adult

    Institute of Scientific and Technical Information of China (English)

    李秋桂; 姬芳勤

    2014-01-01

    目的:分析成人身体成分与血脂、血糖指标之间的关系方法选择成年体检者490名,排除严重心脑肝肾疾病,肿瘤患者,急性炎症患者及长期服药者等。通过Biospace InBody 220人体成分分析仪对身体水分、蛋白质、无机盐、体脂肪、体重、骨骼肌肉量、体质指数、体脂百分比、腰臀脂肪比等指标进行测定。同时测定空腹血糖、血脂指标。所有指标的测定均由我院医护人员经过统一培训后进行操作。结果男女性别年龄无差异(p>0.05)。除体脂肪外,男女性别间身体水分、蛋白质、无机盐、体重、骨骼肌肉量、体质指数、体脂百分比、腰臀脂肪比均有显著差异(均p<0.001)。蛋白质、体脂肪、体重、骨骼肌肉量、体质指数、体脂百分比、腰臀脂肪比与空腹血糖呈正相关(均p<0.05)。身体水分、蛋白质、无机盐、体脂肪、体重、骨骼肌肉量、体质指数、体脂百分比、腰臀脂肪比均可对血脂(总胆固醇、甘油三酯)产生影响(均p<0.05)。剔除性别因素后,对身体成分与血糖、血脂各指标进行偏相关分析,体脂肪、体重、体质指数、体脂百分比、腰臀脂肪比仍然与血糖、总胆固醇、甘油三酯呈正相关(均p<0.05)。结论成人身体成分与血糖、血脂指标密切相关。通过身体成分的分析,可尽早预防代谢相关性疾病。%Objective To analyze the relationship between body composition and fasting serum lipids, fasting blood glucose in adult. Methods Select 490 adult, eliminate the subjects who has the serious cardiovascular diseases, liver diseases , kidney diseases, cancer and the subjects with acute inflammation and long term medication etc. Body moisture, protein, inorganic salt, fat, skeletal muscle weight, body mass index, percentage of body fat, waist and hip fat ratio was determined by Biospace InBody 220. Measure the

  3. 正常糖代谢肥胖女性体成分改变及β细胞功能分析%Association of body composition and β-cell function in obese females with normal glucose metabolism

    Institute of Scientific and Technical Information of China (English)

    严孙杰; 沈喜妹; 颜晓芳; 易如海; 吴佩文; 杨立勇; 张松菁

    2009-01-01

    Objective To explore the relationship between body composition and β-cell function in obese females with normal glucose metabolism. Methods Seventy-five obese women with normal blood glucose and without family history of diabetes were investigated. They were assigned to 4 groups based on body mass index (BMI). Body fat content was measured by dual-energy X-ray absorptiometry (DEXA), and intravenous glucose tolerance test (IVGTT) was performed. The acute insulin response (AIR), the area under the curve (AUC) of insulin (AUCins) and homeostasis model assessment (HOMA) for β-cell function (HOMA2-% B) were calculated. Insulin resistance index(HOMA2-IR) and the ratio of AUCins to AUC of glucose (AUCins/AUCglu) were calculated to assess insulin resistance. Results Women with higher BMI appeared to have more total body fat content and trunk fat content. The similar distribution was also found in other parameters, including the plasma glucose levels at 0 and 10 min, AUCins, AIR, AUCins/AUCglu and the difference of insulin level between 0 and 10 min [INS (10-0)] during IVGTF. AUCins, AIR, AUCins/AUCglu and [INS (10-0)] were positively correlated with the age, BMI,total body fat content and trunk fat content. After adjustment of age, the trunk fat content was independently associated with the AIR in a good linear manner. Conclusion The obese females show change in body composition with more trunk fat content. They show significant insulin resistance with compensated elevation of insulin secretion. Body composition assessment is a valid and more accurate method than BMI and waist circumference in predicting early damaged β-cell function in obese patients.%目的 了解无糖尿病家族史、正常糖代谢肥胖女性体成分改变及胰岛β细胞功能变化.方法 双能X线骨密度仪(DXEA)检测75名入选对象体成分,并行静脉葡萄糖耐量试验(IVGTT),按体重指数(BMI)水平分为4组.以胰岛素曲线下面积(AUCins)、胰岛素急性时相分

  4. Body composition in clinical practice.

    Science.gov (United States)

    Andreoli, Angela; Garaci, Francesco; Cafarelli, Francesco Pio; Guglielmi, Giuseppe

    2016-08-01

    Nutritional status is the results of nutrients intake, absorption and utilization, able to influence physiological and pathological conditions. Nutritional status can be measured for individuals with different techniques, such as CT Body Composition, quantitative Magnetic Resonance Imaging, Ultrasound, Dual-Energy X-Ray Absorptiometry and Bioimpendance. Because obesity is becoming a worldwide epidemic, there is an increasing interest in the study of body composition to monitor conditions and delay in development of obesity-related diseases. The emergence of these evidence demonstrates the need of standard assessment of nutritional status based on body weight changes, playing an important role in several clinical setting, such as in quantitative measurement of tissues and their fluctuations in body composition, in survival rate, in pathologic condition and illnesses. Since body mass index has been shown to be an imprecise measurement of fat-free and fat mass, body cell mass and fluids, providing no information if weight changes, consequently there is the need to find a better way to evaluate body composition, in order to assess fat-free and fat mass with weight gain and loss, and during ageing. Monitoring body composition can be very useful for nutritional and medical interventional. This review is focused on the use of Body Composition in Clinical Practice.

  5. Impact of Glucose Tolerance Status, Sex, and Body Size on Glucose Absorption Patterns During OGTTs

    DEFF Research Database (Denmark)

    Faerch, K.; Pacini, G.; Nolan, J. J.;

    2013-01-01

    OBJECTIVEWe studied whether patterns of glucose absorption during oral glucose tolerance tests (OGTTs) were abnormal in individuals with impaired glucose regulation and whether they were related to sex and body size (height and fat-free mass). We also examined how well differences in insulin......), isolated impaired fasting glucose (i-IFG), or isolated impaired glucose tolerance (i-IGT). Insulin sensitivity and -cell function were measured with the euglycemic-hyperinsulinemic clamp and intravenous glucose tolerance tests, respectively. Surrogate markers of both conditions were calculated from OGTTs...... size were taken into account (P > 0.28). Faster glucose absorption was related to higher fasting (P = 0.001) and lower 2-h (P = 0.001) glucose levels and to greater height and fat-free mass (P

  6. Assessment methods of body composition

    Directory of Open Access Journals (Sweden)

    Karaba-Jakovljević Dea

    2016-01-01

    Full Text Available Body composition assessment has an important role in many fields of medicine, in evaluation of health status of the individual, as well as in sports sciences as a part of physiological profile of athletes. There are several methods for body composition assessment, which provide indirect data on the body structure. For instance in anthropometry, simple techniques such as skinfold measurements provide simply, quick and nonexpensive assessment of body fat mass. Bioelectric impedance analysis (BIA is described as a method with rising validity, especially for measurement in regional body composition. The value of BIA in routine clinical terms is still limited, while DXA has potential of becoming new golden standard for body composition assessment. More sophisiticated methods such is MRI have advantage over other techniques for estimation of regional body composition, since it provides the only accurate and viable approach for the estimation of intra-abdominal adipose tissue. This method is limited to experimental studies on smaller group of individuals, since it is expensive and not available to routine assessment. Combination of more methods may be the best approach for obtaining accurate results and informations about health status of individual.

  7. Energy expenditure, body composition and insulin response to glucose in male twins discordant for the Trp64Arg polymorphism of the beta3-adrenergic receptor gene

    DEFF Research Database (Denmark)

    Højlund, K; Christiansen, C; Bjørnsbo, K S;

    2006-01-01

    and environmental background, the Trp64Arg polymorphism of the beta3AR gene is associated with lower fat mass, fasting insulin levels and an appropriate insulin response to glucose. Thus, heterozygosity for the Trp64Arg variant is unlikely to increase the risk of obesity, insulin resistance or type 2 diabetes.......AIM: The tryptophan to arginine change in position 64 (Trp64Arg) polymorphism of the beta3-adrenergic receptor (beta3AR) gene has been associated with an increased prevalence of obesity, insulin resistance and type 2 diabetes. In this, decreased rates of energy expenditure and impaired insulin......-ray absorptiometry scanning and energy expenditure by indirect and direct calorimetry. RESULTS: Twins heterozygous for the Trp64Arg polymorphism showed significantly lower fat mass independent of the method used, and significantly lower fasting insulin and glucose concentrations compared with their homozygous wild...

  8. Assessing plasma glucose and lipid levels, body weight and acute ...

    African Journals Online (AJOL)

    Assessing plasma glucose and lipid levels, body weight and acute toxicity following oral ... Diabetes was induced in male and female Wistar rats with alloxan ... had good hypoglycemic activity and good effects on cardiovascular risk factors.

  9. Postpartum changes in body composition.

    Science.gov (United States)

    Cho, Geum Joon; Yoon, Hyo Jin; Kim, Eung-Ju; Oh, Min-Jeong; Seo, Hong-Seog; Kim, Hai-Joong

    2011-12-01

    Parity is associated with weight retention and has long-lasting and detrimental effects on the health of women. Previous studies have shown that increasing parity was independently associated with an increased prevalence of metabolic syndrome. Postpartum weight is made up of several components including uterine and mammary tissues, body water (intracellular (ICW) and extracellular water (ECW)), and fat. These components change in variable amounts postpartum, thereby distinctly affecting the interpretation of individual weight retention; however, it is unclear which components contribute to weight retention. The aims of this longitudinal study were to evaluate changes in body composition during the postpartum period and to investigate their effects on weight retention. This prospective study examined 41 healthy, pregnant women who gave birth at Korea University Guro Hospital. We measured body composition at 2 days, 2 weeks, and 6 weeks postpartum using bioelectrical impedance analysis. Weight decreased during this postpartum period (P < 0.001); the postpartum weight retention from prepregnancy to 6 weeks postpartum was 4.43 ± 4.0 kg. Among various body composition components, ECW, ICW, total body water, and fat-free mass (FFM) decreased postpartum. However, fat mass (FM) and visceral fat area, the components that experienced the greatest changes, increased postpartum. Our results demonstrate that the postpartum period is associated with a preferential accumulation of adipose tissue in the visceral compartment, even though overall body weight is decreased. Further studies are needed to evaluate the changes in body composition over longer time periods and their long-term effects on health.

  10. Correlation between macrosomia body indices and maternal fasting blood glucose.

    Science.gov (United States)

    Song, Y; Zhang, S; Song, W

    2014-05-01

    To explore the significance of neonatal body indices in identifying pathological macrosomia, we implemented a retrospective study of 254 neonates, including: 100 macrosomia of diabetic pregnancies, 77 macrosomia of healthy pregnancies and 77 normal neonates of healthy pregnancies, using their birth weight, body length, head circumference and chest circumference, to calculate neonatal body indices, multiple regression analysis of the correlation between newborn body indices and maternal fasting blood glucose. The Quetelet Index and Kaup Index of diabetic macrosomia is higher than that of non-diabetic macrosomia; HC:CC (ratio between head circumference and chest circumference) is reversed (p macrosomia.

  11. Glucose and ketone body kinetics in diabetic ketoacidosis.

    Science.gov (United States)

    Miles, J M; Gerich, J E

    1983-07-01

    The hyperglycaemia and hyperketonaemia of diabetic ketoacidosis are initiated primarily by overproduction of these substrates; subsequent maintenance of hyperglycaemia occurs, in large part, due to impaired utilization of glucose, whereas overproduction of ketone bodies continues to be the major mechanism for maintenance of hyperketonaemia. Insulin deficiency results in increased rates of lipolysis and provides increased substrate (free fatty acids) for ketogenesis. Hyperglucagonaemia can augment ketogenesis further in the setting of insulin deficiency. It is likely that other counter-insulin hormones (growth hormone, catecholamines) also contribute to the pathogenesis of DKA, though their role is less well defined. Insulin corrects DKA largely via suppression of lipolysis (and thus ketone body production); insulin suppresses glucose production at lower levels than it does ketone body production.

  12. The effect of 30 months of low-dose replacement therapy with recombinant human growth hormone (rhGH) on insulin and C-peptide kinetics, insulin secretion, insulin sensitivity, glucose effectiveness, and body composition in GH-deficient adults

    DEFF Research Database (Denmark)

    Rosenfalck, A M; Maghsoudi, S; Fisker, S

    2000-01-01

    the insulin sensitivity index, calculated from the frequently sampled iv glucose tolerance test, only decreased slightly. The clearance of C-peptide and insulin increased 100% and 60%, respectively, and the prehepatic insulin secretion was tripled during rhGH treatment; but related to the impairment...... an increase in lean body mass and a reduction of fat mass. Therefore, rhGH treatment may precipitate diabetes in some patients already susceptible to the disorder....

  13. Effect of Body Composition on Walking Economy

    OpenAIRE

    Maciejczyk Marcin; Wiecek Magdalena; Szymura Jadwiga; Szygula Zbigniew

    2016-01-01

    Purpose. The aim of the study was to evaluate walking economy and physiological responses at two walking speeds in males with similar absolute body mass but different body composition. Methods. The study involved 22 young men with similar absolute body mass, BMI, aerobic performance, calf and thigh circumference. The participants differed in body composition: body fat (HBF group) and lean body mass (HLBM group). In the graded test, maximal oxygen uptake (VO2max) and maximal heart rate were me...

  14. Nutritional aspects and body composition in motocross

    OpenAIRE

    Mňuk, Josef

    2015-01-01

    Title: Nutritional aspects and body composition in motocross Objectives: The goal of this work is monitoring nutritional habits and parameters for the assessment of body composition and somatotype for Czech junior national team in motocross and enduro. Methotds: There was used four day record of consumed food to map out nutritional habits, which was evaluted by software Nutirs. The input data of body composition were obtained by Bioimpendance InBody 230. Following were also measured selected ...

  15. A refractometry-based glucose analysis of body fluids.

    Science.gov (United States)

    Zirk, Kai; Poetzschke, Harald

    2007-05-01

    In principle, refractometry appears to be a suitable method for the measurement of glucose concentrations in body fluids (such as blood and the intercellular fluid), even though the refractive index of the measured samples, as an additive property, is not specific. But, if certain conditions are fulfilled, the glucose content can be calculated using the refractive index in combination with values from a further measurement. This study describes the determination of the glucose content using refractometry in human blood serum derivates, which were selected - due to their ready availability - to be used as a model for interstitial fluid. Refractometry of body fluids requires the elimination of disturbing components from the measurement sample. First of all, a homogenous fluid (i.e. consisting of one phase) is required, so that all cells and components in suspension need to be separated out. Furthermore, certain dissolved macromolecular components which are known to disturb the measurement process must also be removed. In human serum samples which had been ultrafiltrated with a range of ultrafilters of different pore sizes, a comparative evaluation showed that only ultrafiltration through a filter with a separation limit of between 3 and 30kDa resulted in maximal reduction of the refractive index (compared to native serum), whereas ultrafilters with greater separation limits did not. The total content of osmotically active solutes (the tonicity) also exerts a clear influence. However, exemplary measurements in blood plasma fluid from one volunteer showed that the electrical conductivity is (without an additive component) directly proportional to the osmolality: physiological changes in the state of body hydration (hyperhydration and dehydration) do not lead to any considerable changes in the relation between ionised and uncharged solute particles, but instead result in a sufficiently clear dilution or concentration of the blood fluid's low molecular components. This

  16. Development of methods for body composition studies

    Energy Technology Data Exchange (ETDEWEB)

    Mattsson, Soeren [Department of Radiation Physics, Lund University, Malmoe University Hospital, SE-205 02 Malmoe (Sweden); Thomas, Brian J [School of Physical and Chemical Sciences, Queensland University of Technology, Brisbane, QLD 4001 (Australia)

    2006-07-07

    This review is focused on experimental methods for determination of the composition of the human body, its organs and tissues. It summarizes the development and current status of fat determinations from body density, total body water determinations through the dilution technique, whole and partial body potassium measurements for body cell mass estimates, in vivo neutron activation analysis for body protein measurements, dual-energy absorptiometry (DEXA), computed tomography (CT) and magnetic resonance imaging (MRI, fMRI) and spectroscopy (MRS) for body composition studies on tissue and organ levels, as well as single- and multiple-frequency bioimpedance (BIA) and anthropometry as simple easily available methods. Methods for trace element analysis in vivo are also described. Using this wide range of measurement methods, together with gradually improved body composition models, it is now possible to quantify a number of body components and follow their changes in health and disease. (review)

  17. Effect of abomasal glucose infusion on splanchnic and whole-body glucose metabolism in periparturient dairy cows

    DEFF Research Database (Denmark)

    Larsen, Mogens; Kristensen, Niels Bastian

    2009-01-01

    Six periparturient Holstein cows fitted with ruminal cannulas and permanent indwelling catheters in the hepatic portal vein, hepatic vein, mesenteric vein, and an artery were used to study the effects of abomasal glucose infusion on splanchnic and whole-body glucose metabolism.......Six periparturient Holstein cows fitted with ruminal cannulas and permanent indwelling catheters in the hepatic portal vein, hepatic vein, mesenteric vein, and an artery were used to study the effects of abomasal glucose infusion on splanchnic and whole-body glucose metabolism....

  18. Composition of Solar System Small Bodies

    CERN Document Server

    Vernazza, Pierre

    2016-01-01

    The aim of the chapter is to summarize our understanding of the compositional distribution across the different reservoirs of small bodies (main belt asteroids, giant planet trojans, irregular satellites of the giant planets, TNOs, comets). We then use this information to i) discuss current dynamical models (Nice and Grand Tack models), ii) mention possible caveats in these models if any, and iii) draw a preliminary version of the primordial compositional gradient across the solar system before planetary migrations occured. Note that the composition of both planetary satellites (the regular ones) and that of the transient populations (NEOs, centaurs) is not discussed here. We strictly focus on the composition of the main reservoirs of small bodies. The manuscript's objective is to provide a global and synthetic view of small bodies' compositions rather than a very detailed one, for specific reviews regarding the composition of small bodies, see papers by Burbine (2014) for asteroids, Emery et al. (2015) for J...

  19. Carbon nanotube composites for glucose biosensor incorporated with reverse iontophoresis function for noninvasive glucose monitoring

    Directory of Open Access Journals (Sweden)

    Tai-Ping Sun

    2010-05-01

    Full Text Available Tai-Ping Sun1,2,5, Hsiu-Li Shieh2, Congo Tak-Shing Ching1,2,5, Yan-Dong Yao3, Su-Hua Huang4, Chia-Ming Liu1, Wei-Hao Liu1, Chung-Yuan Chen21Graduate Institute of Biomedicine and Biomedical Technology, 2Department of Electrical Engineering, National Chi Nan University, Nantou, Taiwan, ROC; 3Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong; 4Department of Biotechnology, Asia University, Taichung, Taiwan, ROC; 5These authors contributed equally to this workAbstract: This study aims to develop an amperometric glucose biosensor, based on carbon nanotubes material for reverse iontophoresis, fabricated by immobilizing a mixture of glucose oxidase (GOD and multiwalled carbon nanotubes (MWCNT epoxy-composite, on a planar screen-printed carbon electrode. MWCNT was employed to ensure proper incorporation into the epoxy mixture and faster electron transfer between the GOD and the transducer. Results showed this biosensor possesses a low detection potential (+500 mV, good sensitivity (4 μA/mM and an excellent linear response range (r2 = 0.999; 0–4 mM of glucose detection at +500 mV (versus Ag/AgCl. The response time of the biosensor was about 25 s. In addition, the biosensor could be used in conjunction with reverse iontophoresis technique. In an actual evaluation model, an excellent linear relationship (r2 = 0.986 was found between the glucose concentration of the actual model and the biosensor’s current response. Thus, a glucose biosensor based on carbon nanotube composites and incorporated with reverse iontophoresis function was developed.Keywords: amperometric, carbon nanotubes, glucose monitoring, biosensors, reverse iontophoresis

  20. Body composition and risk for metabolic alterations in female adolescents

    Directory of Open Access Journals (Sweden)

    Eliane Rodrigues de Faria

    2014-06-01

    Full Text Available OBJECTIVE: To study anthropometrical and body composition variables as predictors of risk for metabolic alterations and metabolic syndrome in female adolescents.METHODS: Biochemical, clinical and corporal composition data of 100 adolescents from 14 to 17 years old, who attended public schools in Viçosa, Southeastern Brazil, were collected.RESULTS: Regarding nutritional status, 83, 11 and 6% showed eutrophia, overweight/obesity and low weight, respectively, and 61% presented high body fat percent. Total cholesterol presented the highest percentage of inadequacy (57%, followed by high-density lipoprotein (HDL - 50%, low-density lipoprotein (LDL - 47% and triacylglycerol (22%. Inadequacy was observed in 11, 9, 3 and 4% in relation to insulin resistance, fasting insulin, blood pressure and glycemia, respectively. The highest values of the fasting insulin and the Homeostasis Model Assessment-Insulin Resistance(HOMA-IR were verified at the highest quartiles of body mass index (BMI, waist perimeter, waist-to-height ratio and body fat percent. Body mass index, waist perimeter, and waist-to-height ratio were the better predictors for high levels of HOMA-IR, blood glucose and fasting insulin. Waist-to-hip ratio was associated to arterial hypertension diagnosis. All body composition variables were effective in metabolic syndrome diagnosis.CONCLUSIONS: Waist perimeter, BMI and waist-to-height ratio showed to be good predictors for metabolic alterations in female adolescents and then should be used together for the nutritional assessment in this age range.

  1. Impacts of parturition and body condition score on glucose uptake capacity of bovine monocyte subsets.

    Science.gov (United States)

    Eger, Melanie; Hussen, Jamal; Drong, Caroline; Meyer, Ulrich; von Soosten, Dirk; Frahm, Jana; Daenicke, Sven; Breves, Gerhard; Schuberth, Hans-Joachim

    2015-07-15

    The peripartal period of dairy cows is associated with a higher incidence of infectious diseases like mastitis or metritis, particularly in high-yielding animals. The onset of lactation induces a negative energy balance and a shift of glucose distribution toward the udder. Glucose is used as primary fuel by monocytes which give rise to macrophages, key cells in the defense against pathogens. The aim of this study was to analyze whether animals with high or low body condition score (BCS) differ in composition and glucose uptake capacities of bovine monocyte subsets. Blood samples were taken from 27 dairy cows starting 42 days before parturition until day 56 after parturition. The cows were allocated to two groups according to their BCS. A feeding regime was applied, in which the BCS high group received higher amounts of concentrate before parturition and concentrate feeding was more restricted in the BCS high group after parturition compared with the BCS low group, to promote postpartal lipolysis and enhance negative energy balance in the BCS high group. Blood cell counts of classical (cM), intermediate (intM) and nonclassical monocytes (ncM) were increased at day 7 after calving. In the BCS low group intM numbers were significantly higher compared to the BCS high group at day 7 after parturition. Within the BCS low group cows suffering from mastitis or metritis showed significantly higher numbers of cM, intM and ncM at day 7 after parturition. Classical monocytes and intM showed similar glucose uptake capacities while values for ncM were significantly lower. Compared with antepartal capacities and irrespective of BCS and postpartal mastitis or metritis, glucose uptake of all monocyte subsets decreased after parturition. In conclusion, whereas glucose uptake capacity of bovine monocyte subsets is altered by parturition, it is not linked to the energy supply of the animals or to postpartal infectious diseases.

  2. Assessing body composition in infants and toddlers

    Science.gov (United States)

    The objective of this study was to compare different body composition techniques in infants and toddlers. Anthropometric measures including mid-upper arm circumference (MAC), triceps skinfold thickness (TSF), and weight-for-height or -length Z-scores (WHZ), and measures of body fat mass assessed wit...

  3. Measurement of Body Composition in Children.

    Science.gov (United States)

    Lohman, T. G.

    1982-01-01

    Identification and treatment of obesity in children is believed to be an important factor in its control during the adult years. Laboratory and field methods for body composition measurement are described along with estimates of body fat content from anthropometric dimensions. (CJ)

  4. Body composition in Egyptian Turner syndrome girls

    Directory of Open Access Journals (Sweden)

    Moushira Erfan Zaki

    2013-01-01

    Full Text Available Objective: This cross-sectional study was undertaken to construct the new body fat % curve and provide body composition reference data for adolescent girls with Turner syndrome (TS. They diagnosed cytogenetically by blood karyotyping and not treated with growth hormone (GH. Materials and Methods: The study included 70 TS girls from age 13 years to age 17 years. Body composition was measured by bioelectrical impedance. Smoothed centile charts were derived by using the least mean square (LMS method. Results: The new body fat curves reflect the increase of body fat mass (FM from age 13 years to age 17 years. Body FM % of Egyptian TS girls was lower when compared with age-matched American untreated TS girls. Conclusion: This study presents the new body fat curves and reference values of body composition for untreated Egyptian TS adolescent girls. The present charts can be used for direct assessment of body FM % for Egyptian TS girls and evaluation for cases on GH treatment or other growth promoting therapy.

  5. Effect of abomasal glucose infusion on splanchnic and whole-body glucose metabolism in periparturient dairy cows.

    Science.gov (United States)

    Larsen, M; Kristensen, N B

    2009-03-01

    Six periparturient Holstein cows fitted with ruminal cannulas and permanent indwelling catheters in the hepatic portal vein, hepatic vein, mesenteric vein, and an artery were used to study the effects of abomasal glucose infusion on splanchnic and whole-body glucose metabolism. The experimental design was a split plot, with cow as the whole plot, treatment as the whole-plot factor, and days in milk (DIM) as the subplot factor. Cows were assigned to 1 of 2 treatments: the control (no infusion) or infusion (1,500 g/d of glucose infused into the abomasum from the day of calving). Cows were sampled at 12 d prepartum and at 4, 15, and 29 DIM. To study portal-drained visceral uptake of arterial glucose, [U-(13)C]glucose was continuously infused into the jugular vein on sampling days. Postpartum, voluntary dry matter intake and milk yield increased at a lower rate with the infusion compared with the control. The net portal flux of glucose increased with the infusion compared with the control, and 67 +/- 5% of the infused glucose was recovered as increased portal flux of glucose. The net hepatic flux of glucose was lower with the infusion compared with the control; however, the net hepatic flux of glucose per kilogram of dry matter intake was not affected by treatment. The arterial concentrations of glucose and insulin decreased and concentrations of nonesterified fatty acids increased from prepartum to 4 DIM with the control, but these effects were not observed with the infusion. The arterial concentration of beta-hydroxybutyrate decreased more from prepartum to 4 DIM with the infusion, compared with the control. Uptake of arterial [U-(13)C]glucose in the portal-drained viscera was affected neither by the infusion nor by the DIM and averaged 2.5 +/- 0.2%. The whole-body glucose supply changed to be less dependent on the recycling of lactate (Cori cycle) with the infusion. It was concluded that small intestinal glucose absorption is an efficient source of glucose to the

  6. BIOSENSORS: A SENSITIVE STRATEGY TO DETECT GLUCOSE IN BODY FLUIDS

    Directory of Open Access Journals (Sweden)

    Riddhi Patel

    2015-03-01

    Full Text Available Over the past decades diabetes is one of the leading causes of mortality and morbidity in the world, thus inventing glucose biosensors with accurate continuous monitoring is of growing concern amongst the scientists worldwide. This manuscript reviews the development of glucose biosensors over the last 50 years since the invention of the first glucose sensing electrode and various approaches considered to develop accurate and modern techniques of glucose sensing. This review provides brief introduction to principles of various glucose biosensors with systemization and classification of glucose monitoring principles. Thus the main aim of this manuscript is to check history of glucose biosensors, comment on their current status and commercial aspects, and examine future challenges.

  7. Body Composition Changes Associated With Methadone Treatment

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    Sadek

    2016-02-01

    Full Text Available Background Methadone is associated with a statistically significant increase in BMI in the first 2 years of treatment. Objectives To evaluate the changes of body composition (bone mass, % fat, % muscle mass, % water, and basal metabolic rate related to this increase. Patients and Methods Changes in body composition were monitored, via bioelectrical impedance, in 29 patients in methadone treatment for opiate dependency (age 18 to 44, mean = 29.3, SD = 7.0, 13 men, 16 women. Results Within one year from admission to treatment, a statistically significant (t-tests, P < 0.05 increase was noted in their body mass index (BMI, % of body fat, average body mass, and average basal metabolic rate, and relative decrease in their % of muscle mass and % of bone mass. Neither absolute bone mass nor muscle mass changed significantly. Conclusions Physicians involved in care of methadone patients should recommend dietary and lifestyle changes to improve their overall health.

  8. Effect of Body Composition on Walking Economy

    Directory of Open Access Journals (Sweden)

    Maciejczyk Marcin

    2016-12-01

    Full Text Available Purpose. The aim of the study was to evaluate walking economy and physiological responses at two walking speeds in males with similar absolute body mass but different body composition. Methods. The study involved 22 young men with similar absolute body mass, BMI, aerobic performance, calf and thigh circumference. The participants differed in body composition: body fat (HBF group and lean body mass (HLBM group. In the graded test, maximal oxygen uptake (VO2max and maximal heart rate were measured. Walking economy was evaluated during two walks performed at two different speeds (4.8 and 6.0 km ‧ h-1. Results. The VO2max was similar in both groups, as were the physiological responses during slow walking. The absolute oxygen uptake or oxygen uptake relative to body mass did not significantly differentiate the studied groups. The only indicator significantly differentiating the two groups was oxygen uptake relative to LBM. Conclusions. Body composition does not significantly affect walking economy at low speed, while during brisk walking, the economy is better in the HLBM vs. HBF group, provided that walking economy is presented as oxygen uptake relative to LBM. For this reason, we recommend this manner of oxygen uptake normalization in the evaluation of walking economy.

  9. Skeletal and body composition evaluation

    Science.gov (United States)

    Mazess, R. B.

    1983-01-01

    Research on radiation detectors for absorptiometry; analysis of errors affective single photon absorptiometry and development of instrumentation; analysis of errors affecting dual photon absorptiometry and development of instrumentation; comparison of skeletal measurements with other techniques; cooperation with NASA projects for skeletal evaluation in spaceflight (Experiment MO-78) and in laboratory studies with immobilized animals; studies of postmenopausal osteoporosis; organization of scientific meetings and workshops on absorptiometric measurement; and development of instrumentation for measurement of fluid shifts in the human body were performed. Instrumentation was developed that allows accurate and precise (2% error) measurements of mineral content in compact and trabecular bone and of the total skeleton. Instrumentation was also developed to measure fluid shifts in the extremities. Radiation exposure with those procedures is low (2-10 MREM). One hundred seventy three technical reports and one hundred and four published papers of studies from the University of Wisconsin Bone Mineral Lab are listed.

  10. Contemporary methods of body composition measurement

    DEFF Research Database (Denmark)

    Fosbøl, Marie Ø; Zerahn, Bo

    2015-01-01

    . This review is focused on currently applied methods for in vivo measurement of body composition, including densitometry, bioimpedance analysis, dual-energy X-ray absorptiometry, computed tomography (CT), magnetic resonance techniques and anthropometry. Multicompartment models including quantification of trace......Reliable and valid body composition assessment is important in both clinical and research settings. A multitude of methods and techniques for body composition measurement exist, all with inherent problems, whether in measurement methodology or in the assumptions upon which they are based...... elements by in vivo neutron activation analysis, which are regarded as gold standard methods, are also summarized. The choice of a specific method or combination of methods for a particular study depends on various considerations including accuracy, precision, subject acceptability, convenience, cost...

  11. Evaluation of body composition. Current issues.

    Science.gov (United States)

    Heyward, V H

    1996-09-01

    In the selection of body composition field methods and prediction equations, exercise and health practitioners must consider their clients' demographics. Factors, such as age, gender, level of adiposity, physical activity and ethnicity influence the choice of method and equation. Also, it is important to evaluate the relative worth of prediction equations in terms of the criterion method used to derive reference measures of body composition for equation development. Given that hydrodensitometry, hydrometry and dual-energy x-ray absorptiometry are subject to measurement error and violation of basic assumptions underlying their use, none of these should be considered as a 'gold standard' method for in vivo body composition assessment. Reference methods, based on whole-body, 2-component body composition models, are limited, particularly for individuals whose fat-free body (FFB) density and hydration differ from values assumed for 2-component models. Use of field method prediction equations developed from 2-component model (Siri equation) reference measures of body composition will systematically underestimate relative body fatness of American Indian women, Black men and women, and Hispanic women because the average FFB density of these ethnic groups exceeds the assumed value (1.1 g/ml). Thus, some researchers have developed prediction equations based on multicomponent model estimates of body composition that take into account interindividual variability in the water, mineral, and protein content of the FFB. One multicomponent model approach adjusts body density (measured via hydrodensitometry) for total body water (measured by hydrometry) and/or total body mineral estimated from bone mineral (measured via dual-energy x-ray absorptiometry). Skinfold (SKF), bioelectrical impedance analysis (BIA), and near-infrared interactance (NIR) are 3 body composition methods used in clinical settings. Unfortunately, the overwhelming majority of field method prediction equations

  12. Childhood body composition in relation to body mass index.

    Science.gov (United States)

    Maynard, L M; Wisemandle, W; Roche, A F; Chumlea, W C; Guo, S S; Siervogel, R M

    2001-02-01

    The aim is to describe body composition in relation to body mass index (BMI; body weight/stature(2)) to provide health care professionals insight into the meaning, significance, and limitations of BMI as an index of adiposity during childhood. Data from 387 healthy, white children 8 to 18 years of age from the Fels Longitudinal Study were analyzed. Measurements were scheduled annually and each child was examined 1 to 11 times, totaling 1748 observations. Total body fat (TBF) and fat-free mass (FFM) were determined from hydrodensitometry. Stature and weight were measured using standard methods and BMI and the components of BMI, TBF/stature(2), and FFM/stature(2) were calculated. Analyses included correlations between BMI and body composition variables; age-related patterns of BMI, TBF/stature(2), and FFM/stature(2); and annual changes in BMI, TBF/stature(2), and FFM/stature(2). Generally, correlations between BMI and body composition variables were strong and significantly different from zero. Means for BMI throughout childhood were similar for boys and girls, although significantly larger values were observed for girls at ages 12 to 13 years. Age-related patterns of TBF/stature(2) and FFM/stature(2) differed between sexes. In each sex, annual increases in BMI were driven primarily by increases in FFM/stature(2) until late adolescence, with increases in TBF/stature(2) contributing to a larger proportion of the BMI increases in girls than in boys. Unlike adults, annual increases in BMI during childhood are generally attributed to the lean rather than to the fat component of BMI. Because the properties of BMI vary during childhood, health care professionals must consider factors such as age and sex when interpreting BMI.

  13. Maternal Physical Activity and Insulin Action in Pregnancy and Their Relationships With Infant Body Composition

    OpenAIRE

    Pomeroy, Jeremy; Renström, Frida; Gradmark, Anna M.; Mogren, Ingrid; Persson, Margareta; Bluck, Les; Wright, Antony; Kahn, Steven E; Domellöf, Magnus; Franks, Paul W.

    2013-01-01

    OBJECTIVE We sought to assess the association between maternal gestational physical activity and insulin action and body composition in early infancy. RESEARCH DESIGN AND METHODS At 28–32 weeks' gestation, pregnant women participating in an observational study in Sweden underwent assessments of height, weight, and body composition, an oral glucose tolerance test, and 10 days of objective physical activity assessment. Thirty mothers and infants returned at 11–19 weeks postpartum. Infants under...

  14. Control of blood glucose in type 2 diabetes without weight loss by modification of diet composition

    Directory of Open Access Journals (Sweden)

    Gannon Mary C

    2006-03-01

    Full Text Available Abstract Background Over the past several years our research group has taken a systematic, comprehensive approach to determining the effects on body function (hormonal and non-hormonal of varying the amounts and types of proteins, carbohydrates and fats in the diet. We have been particularly interested in the dietary management of type 2 diabetes. Our objective has been to develop a diet for people with type 2 diabetes that does not require weight loss, oral agents, or insulin, but that still controls the blood glucose concentration. Our overall goal is to enable the person with type 2 diabetes to control their blood glucose by adjustment in the composition rather than the amount of food in their diet. Methods This paper is a brief summary and review of our recent diet-related research, and the rationale used in the development of diets that potentially are useful in the treatment of diabetes. Results We determined that, of the carbohydrates present in the diet, absorbed glucose is largely responsible for the food-induced increase in blood glucose concentration. We also determined that dietary protein increases insulin secretion and lowers blood glucose. Fat does not significantly affect blood glucose, but can affect insulin secretion and modify the absorption of carbohydrates. Based on these data, we tested the efficacy of diets with various protein:carbohydrate:fat ratios for 5 weeks on blood glucose control in people with untreated type 2 diabetes. The results were compared to those obtained in the same subjects after 5 weeks on a control diet with a protein:carbohydrate:fat ratio of 15:55:30. A 30:40:30 ratio diet resulted in a moderate but significant decrease in 24-hour integrated glucose area and % total glycohemoglobin (%tGHb. A 30:20:50 ratio diet resulted in a 38% decrease in 24-hour glucose area, a reduction in fasting glucose to near normal and a decrease in %tGHb from 9.8% to 7.6%. The response to a 30:30:40 ratio diet was similar

  15. Body composition and functional limitation in COPD

    Directory of Open Access Journals (Sweden)

    Katz Patricia P

    2007-01-01

    Full Text Available Abstract Background Low body mass index has been associated with increased mortality in severe COPD. The impact of body composition earlier in the disease remains unclear. We studied the impact of body composition on the risk of functional limitation in COPD. Methods We used bioelectrical impedance to estimate body composition in a cohort of 355 younger adults with COPD who had a broad spectrum of severity. Results Among women, a higher lean-to-fat ratio was associated with a lower risk of self-reported functional limitation after controlling for age, height, pulmonary function impairment, race, education, and smoking history (OR 0.45 per 0.50 increment in lean-to-fat ratio; 95% CI 0.28 to 0.74. Among men, a higher lean-to-fat ratio was associated with a greater distance walked in 6 minutes (mean difference 40 meters per 0.50 ratio increment; 95% CI 9 to 71 meters. In women, the lean-to-fat ratio was associated with an even greater distance walked (mean difference 162 meters per 0.50 increment; 95% CI 97 to 228 meters. In women, higher lean-to-fat ratio was also associated with better Short Physical Performance Battery Scores. In further analysis, the accumulation of greater fat mass, and not the loss of lean mass, was most strongly associated with functional limitation among both sexes. Conclusion Body composition is an important non-pulmonary impairment that modulates the risk of functional limitation in COPD, even after taking pulmonary function into account. Body composition abnormalities may represent an important area for screening and preventive intervention in COPD.

  16. Top 10 Research Questions Related to Body Composition

    Science.gov (United States)

    Going, Scott; Lee, Vinson; Blew, Rob; Laddu, Deepika; Hetherington-Rauth, Megan

    2014-01-01

    An understanding of body composition is crucial to understanding human health, disease, and function. Research in body composition has focused on the development of assessment methods, description of normal changes in body composition with growth and development and aging, and the changes that occur in body composition in response to challenges…

  17. MUSCLE FIBRE TYPE COMPOSITION AND BODY COMPOSITION IN HAMMER THROWERS

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    Gerasimos Terzis

    2010-03-01

    Full Text Available Aim of the present study was to describe the muscle fibre type composition and body composition of well-trained hammer throwers. Six experienced hammer throwers underwent the following measurements: one repetition maximum in squat, snatch, and clean, standing broad jump, backward overhead shot throw and the hammer throw. Dual x-ray absorptiometry was used for body composition analysis. Fibre type composition and cross sectional area was determined in muscle biopsy samples of the right vastus lateralis. Eight physical education students served as a control group. One repetition maximum in squat, snatch and clean for the hammer throwers was 245 ± 21, 132 ± 13 and 165 ± 12kg, respectively. Lean body mass was higher in hammer throwers (85.9 ± 3. 9kg vs. 62.7 ± 5.1kg (p < 0.01. The percentage area of type II muscle fibres was 66.1 ± 4% in hammer throwers and 51 ± 8% in the control group (p < 0.05. Hammer throwers had significantly larger type IIA fibres (7703 ± 1171 vs. 5676 ± 1270μm2, p < 0.01. Hammer throwing performance correlated significantly with lean body mass (r = 0.81, p < 0.05. These data indicate that hammer throwers have larger lean body mass and larger muscular areas occupied by type II fibres, compared with relatively untrained subjects. Moreover, it seems that the enlarged muscle mass of the hammer throwers contributes significantly to the hammer throwing performance

  18. A comparison between the body composition, carcass ...

    African Journals Online (AJOL)

    Jasper

    The body composition, carcass characteristics and retail cuts of 61 Dormers (21 rams ... rams were more developed in the neck and head area than ewes, while ... 200 volts) the sheep were exsanguinated and the carcasses suspended to bleed. ... After 48 hours in the cooler the carcasses were partitioned into South African ...

  19. Writing Bodies: Somatic Mind in Composition Studies.

    Science.gov (United States)

    Fleckenstein, Kristie S.

    1999-01-01

    Discusses the somatic mind, a permeable materiality in which mind and body resolve into a single entity which is (re)formed by the constantly shifting boundaries of discursive and corporeal intertextualities. Addresses its importance in composition studies. Critiques the poststructuralist disregard of corporeality. (CR)

  20. Body composition phenotypes and obesity paradox.

    Science.gov (United States)

    Prado, Carla M; Gonzalez, M Cristina; Heymsfield, Steven B

    2015-11-01

    The obesity paradox is a highly controversial concept that may be attributed to methodological limitations related to its identification. One of the primary concerns is the use of BMI to define obesity. This index does not differentiate lean versus adipose tissue compartments (i.e. body composition) confounding health consequences for morbidity and mortality, especially in clinical populations. This review will describe the past year's evidence on the obesity paradox phenomenon, primarily focusing on the role of abnormal body composition phenotypes in explaining the controversies observed in the literature. In spite of the substantial number of articles investigating the obesity paradox phenomenon, less than 10% used a direct measure of body composition and when included, it was not fully explored (only adipose tissue compartment evaluated). When lean tissue or muscle mass is taken into account, the general finding is that a high BMI has no protective effect in the presence of low muscle mass and that it is the latter that associates with poor prognosis. In view of the body composition variability of patients with identical BMI, it is unreasonable to rely solely on this index to identify obesity. The consequences of a potential insubstantial obesity paradox are mixed messages related to patient-related prognostication.

  1. Muscle fibre type composition and body composition in hammer throwers.

    Science.gov (United States)

    Terzis, Gerasimos; Spengos, Konstantinos; Kavouras, Stavros; Manta, Panagiota; Georgiadis, Giorgos

    2010-01-01

    Aim of the present study was to describe the muscle fibre type composition and body composition of well-trained hammer throwers. Six experienced hammer throwers underwent the following measurements: one repetition maximum in squat, snatch, and clean, standing broad jump, backward overhead shot throw and the hammer throw. Dual x-ray absorptiometry was used for body composition analysis. Fibre type composition and cross sectional area was determined in muscle biopsy samples of the right vastus lateralis. Eight physical education students served as a control group. One repetition maximum in squat, snatch and clean for the hammer throwers was 245 ± 21, 132 ± 13 and 165 ± 12kg, respectively. Lean body mass was higher in hammer throwers (85.9 ± 3. 9kg vs. 62.7 ± 5.1kg (p < 0.01). The percentage area of type II muscle fibres was 66.1 ± 4% in hammer throwers and 51 ± 8% in the control group (p < 0.05). Hammer throwers had significantly larger type IIA fibres (7703 ± 1171 vs. 5676 ± 1270μm(2), p < 0.01). Hammer throwing performance correlated significantly with lean body mass (r = 0.81, p < 0.05). These data indicate that hammer throwers have larger lean body mass and larger muscular areas occupied by type II fibres, compared with relatively untrained subjects. Moreover, it seems that the enlarged muscle mass of the hammer throwers contributes significantly to the hammer throwing performance. Key pointsWell-trained hammer throwers had increased lean body mass, higher type IIA muscle fibres cross sectional areas, as well as higher bone mineral density, compared to controls.Increased lean body mass was closely related with hammer throwing performance.The relative high percentage of type IIX muscle fibres in vastus lateralis in hammer throwers warrants further investigation.

  2. KDT501, a derivative from hops, normalizes glucose metabolism and body weight in rodent models of diabetes.

    Directory of Open Access Journals (Sweden)

    Veera R Konda

    Full Text Available AIMS/HYPOTHESIS: We developed KDT501, a novel substituted 1,3-cyclopentadione chemically derived from hop extracts, and evaluated it in various in vitro and in vivo models of diabetes and insulin sensitivity. METHODS: KDT501 was evaluated for anti-inflammatory effects in monocyte/macrophage cells; agonistic activity for peroxisome proliferator-activated receptors (PPAR; lipogenesis and gene expression profile in human subcutaneous adipocytes. Body composition, glucose, insulin sensitivity, and lipids were assessed in diet-induced obesity (DIO mice and Zucker Diabetic Fatty (ZDF rats after oral administration. RESULTS: KDT501 mediated lipogenesis in 3T3L1 and human subcutaneous adipocytes; however, the gene expression profile of KDT501 differed from that of the full PPARγ agonist rosiglitazone, suggesting that KDT501 has pleiotropic biological activities. In addition, KDT501 showed only modest, partial PPARγ agonist activity and exhibited anti-inflammatory effects in monocytes/macrophages that were not observed with rosiglitazone. In a DIO mouse model, oral administration of KDT501 significantly reduced fed blood glucose, glucose/insulin AUC following an oral glucose bolus, and body fat. In ZDF rats, oral administration of KDT501 significantly reduced fed glucose, fasting plasma glucose, and glucose AUC after an oral glucose bolus. Significant, dose-dependent reductions of plasma hemoglobin A1c, weight gain, total cholesterol, and triglycerides were also observed in animals receiving KDT501. CONCLUSION: These results indicate that KDT501 produces a unique anti-diabetic profile that is distinct in its spectrum of pharmacological effects and biological mechanism from both metformin and pioglitazone. KDT501 may thus constitute a novel therapeutic agent for the treatment of Type 2 diabetes and associated conditions.

  3. Obesity, body composition, and prostate cancer

    Directory of Open Access Journals (Sweden)

    Fowke Jay H

    2012-01-01

    Full Text Available Abstract Background Established risk factors for prostate cancer have not translated to effective prevention or adjuvant care strategies. Several epidemiologic studies suggest greater body adiposity may be a modifiable risk factor for high-grade (Gleason 7, Gleason 8-10 prostate cancer and prostate cancer mortality. However, BMI only approximates body adiposity, and may be confounded by centralized fat deposition or lean body mass in older men. Our objective was to use bioelectric impedance analysis (BIA to measure body composition and determine the association between prostate cancer and total body fat mass (FM fat-free mass (FFM, and percent body fat (%BF, and which body composition measure mediated the association between BMI or waist circumference (WC with prostate cancer. Methods The study used a multi-centered recruitment protocol targeting men scheduled for prostate biopsy. Men without prostate cancer at biopsy served as controls (n = 1057. Prostate cancer cases were classified as having Gleason 6 (n = 402, Gleason 7 (n = 272, or Gleason 8-10 (n = 135 cancer. BIA and body size measures were ascertained by trained staff prior to diagnosis, and clinical and comorbidity status were determined by chart review. Analyses utilized multivariable linear and logistic regression. Results Body size and composition measures were not significantly associated with low-grade (Gleason 6 prostate cancer. In contrast, BMI, WC, FM, and FFM were associated with an increased risk of Gleason 7 and Gleason 8-10 prostate cancer. Furthermore, BMI and WC were no longer associated with Gleason 8-10 (ORBMI = 1.039 (1.000, 1.081, ORWC = 1.016 (0.999, 1.033, continuous scales with control for total body FFM (ORBMI = 0.998 (0.946, 1.052, ORWC = 0.995 (0.974, 1.017. Furthermore, increasing FFM remained significantly associated with Gleason 7 (ORFFM = 1.030 (1.008, 1.052 and Gleason 8-10 (ORFFM = 1.044 (1.014, 1.074 after controlling for FM. Conclusions Our results

  4. Obesity, body composition, and prostate cancer.

    Science.gov (United States)

    Fowke, Jay H; Motley, Saundra S; Concepcion, Raoul S; Penson, David F; Barocas, Daniel A

    2012-01-18

    Established risk factors for prostate cancer have not translated to effective prevention or adjuvant care strategies. Several epidemiologic studies suggest greater body adiposity may be a modifiable risk factor for high-grade (Gleason 7, Gleason 8-10) prostate cancer and prostate cancer mortality. However, BMI only approximates body adiposity, and may be confounded by centralized fat deposition or lean body mass in older men. Our objective was to use bioelectric impedance analysis (BIA) to measure body composition and determine the association between prostate cancer and total body fat mass (FM) fat-free mass (FFM), and percent body fat (%BF), and which body composition measure mediated the association between BMI or waist circumference (WC) with prostate cancer. The study used a multi-centered recruitment protocol targeting men scheduled for prostate biopsy. Men without prostate cancer at biopsy served as controls (n = 1057). Prostate cancer cases were classified as having Gleason 6 (n = 402), Gleason 7 (n = 272), or Gleason 8-10 (n = 135) cancer. BIA and body size measures were ascertained by trained staff prior to diagnosis, and clinical and comorbidity status were determined by chart review. Analyses utilized multivariable linear and logistic regression. Body size and composition measures were not significantly associated with low-grade (Gleason 6) prostate cancer. In contrast, BMI, WC, FM, and FFM were associated with an increased risk of Gleason 7 and Gleason 8-10 prostate cancer. Furthermore, BMI and WC were no longer associated with Gleason 8-10 (OR(BMI) = 1.039 (1.000, 1.081), OR(WC) = 1.016 (0.999, 1.033), continuous scales) with control for total body FFM (OR(BMI) = 0.998 (0.946, 1.052), OR(WC) = 0.995 (0.974, 1.017)). Furthermore, increasing FFM remained significantly associated with Gleason 7 (OR(FFM) = 1.030 (1.008, 1.052)) and Gleason 8-10 (OR(FFM) = 1.044 (1.014, 1.074)) after controlling for FM. Our results suggest that associations between BMI and

  5. Beyond the body mass index: tracking body composition in the pathogenesis of obesity and the metabolic syndrome.

    Science.gov (United States)

    Müller, M J; Lagerpusch, M; Enderle, J; Schautz, B; Heller, M; Bosy-Westphal, A

    2012-12-01

    Body composition is related to various physiological and pathological states. Characterization of individual body components adds to understand metabolic, endocrine and genetic data on obesity and obesity-related metabolic risks, e.g. insulin resistance. The obese phenotype is multifaceted and can be characterized by measures of body fat, leg fat, liver fat and skeletal muscle mass rather than by body mass index. The contribution of either whole body fat or fat distribution or individual fat depots to insulin resistance is moderate, but liver fat has a closer association with (hepatic) insulin resistance. Although liver fat is associated with visceral fat, its effect on insulin resistance is independent of visceral adipose tissue. In contrast to abdominal fat, appendicular or leg fat is inversely related to insulin resistance. The association between 'high fat mass + low muscle mass' (i.e. 'sarcopenic adiposity') and insulin resistance deserves further investigation and also attention in daily clinical practice. In addition to cross-sectional data, longitudinal assessment of body composition during controlled under- and overfeeding of normal-weight healthy young men shows that small decreases and increases in fat mass are associated with corresponding decreases and increases in insulin secretion as well as increases and decreases in insulin sensitivity. However, even under controlled conditions, there is a high intra- and inter-individual variance in the changes of (i) body composition; (ii) the 'body composition-glucose metabolism relationship' and (iii) glucose metabolism itself. Combining individual body components with their related functional aspects (e.g. the endocrine, metabolic and inflammatory profiles) will provide a suitable basis for future definitions of a 'metabolically healthy body composition'. © 2012 The Authors. obesity reviews © 2012 International Association for the Study of Obesity.

  6. Methods for nurses to measure body composition.

    Science.gov (United States)

    Moran, Jose Maria; Lavado-Garcia, Jesus Maria; Pedrera-Zamorano, Juan Diego

    2011-01-01

    Among the methods available for assessing body composition, traditional methods like hydrodensitometry and skin-fold measurements are well known. In this review, we focus on the impedance and interactance methods, which use systems that are usually inexpensive, easily transportable and simple to operate. We also discuss the usefulness of dual energy X-ray absorptiometry, particularly for the measurement of fat distribution. Nurses need to be skilled in the use of the equipment and familiar with the techniques.

  7. Body Fat Content, Distribution and Blood Glucose Concentration ...

    African Journals Online (AJOL)

    Changes in blood glucose level are accompanied by changes in insulin levels which may result to insulin resistance. Raised blood ... To overcome these problems information about causes of diabetes ... Department of Food Technology, Nutrition and Consumer Science; .... determine the significance association between.

  8. Body composition in postpubertal boy cyclists.

    Science.gov (United States)

    Rico, H; Revilla, M; Villa, L F; Gómez-Castresana, F; Alvarez del Buergo, M

    1993-09-01

    Twenty-two young male cyclists aged 15 to 19 years (mean 16.2 +/- 0.4 years) were studied in order to assess the effect of physical training on the body composition of adolescents. The subjects had been training on the road 10 hours per week for over 2 years, and were compared to 22 sedentary normal subjects of similar age range (mean 16.9 +/- 0.3 years). Food and calcium intake was similar in both groups. The total body bone mineral content and total body bone mineral density were lower in the group of cyclist adolescents (p cycling in male adolescents may be associated with a lower bone mass gain. In our opinion, the recommendable nature, quantity and quality of exercise at these ages must be better defined, through additional experimentally-designed studies, in order to prevent negative effects over bone mass gain.

  9. Cinnamon improves insulin sensitivity and alters body composition in an animal model of the metabolic syndrome

    Science.gov (United States)

    Polyphenols from cinnamon (CN) have been described recently as insulin sensitizers and antioxidants, but their effects on the glucose/insulin system in vivo have not been totally investigated. The aim of this study was to determine the effects of CN on insulin resistance and body composition, using ...

  10. Local forearm and whole-body respiratory quotient in humans after an oral glucose load

    DEFF Research Database (Denmark)

    Simonsen, L; Bülow, J; Madsen, J

    1993-01-01

    The effects of an oral glucose load of 75 g on the local forearm and whole-body energy thermogenesis were measured in normal subjects during the 4 h after the glucose intake. Simultaneous assessment of substrate metabolism in the forearm was performed. Energy expenditure (EE) increased after...... the glucose load and had not returned to baseline level at the end of the experiment. Whole-body respiratory quotient (RQ) was, on average, 0.80 (SD 0.05) in the baseline condition and increased to a maximum of 0.91 (0.03) and then decreased to baseline level at the end of the experiment. The local forearm.......17) to 0.63 (0.17) 30 min after the glucose load (P body RQ...

  11. Body Composition at 3-years of Age

    DEFF Research Database (Denmark)

    Ejlerskov, Katrine Tschentscher

    by nutrition this was included in the analyses. Results: In paper I, we showed that a simple model including bioelectrical impedance, height and weight was as good to predict fat-free mass as a more comprehensive model including the sum of subscapularis and triceps skinfolds as well. Prediction error for FFM...... were strongly related to body composition at 3 years. No measures of adiposity (BMI, fat mass, fat mass index and skinfold thickness) were significantly associated to weight gain after 5 months of age. Two interesting effects modifications by full breastfeeding on the effect of birth weight and early...

  12. Dynamic modeling of methylprednisolone effects on body weight and glucose regulation in rats

    Science.gov (United States)

    Fang, Jing; DuBois, Debra C.; He, Yang; Almon, Richard R.

    2012-01-01

    Influences of methylprednisolone (MPL) and food consumption on body weight (BW), and the effects of MPL on glycemic control including food consumption and the dynamic interactions among glucose, insulin, and free fatty acids (FFA) were evaluated in normal male Wistar rats. Six groups of animals received either saline or MPL via subcutaneous infusions at the rate of 0.03, 0.1, 0.2, 0.3 and 0.4 mg/kg/h for different treatment periods. BW and food consumption were measured twice a week. Plasma concentrations of MPL and corticosterone (CST) were determined at animal sacrifice. Plasma glucose, insulin, and FFA were measured at various times after infusion. Plasma MPL concentrations were simulated by a two-compartment model and used as the driving force in the pharmacodynamic (PD) analysis. All data were modeled using ADAPT 5. The MPL treatments caused reduction of food consumption and body weights in all dosing groups. The steroid also caused changes in plasma glucose, insulin, and FFA concentrations. Hyper-insulinemia was achieved rapidly at the first sampling time of 6 h; significant elevations of FFA were observed in all drug treatment groups; whereas only modest increases in plasma glucose were observed in the low dosing groups (0.03 and 0.1 mg/kg/h). Body weight changes were modeled by dual actions of MPL: inhibition of food consumption and stimulation of weight loss, with food consumption accounting for the input of energy for body weight. Dynamic models of glucose and insulin feedback interactions were extended to capture the major metabolic effects of FFA: stimulation of insulin secretion and inhibition of insulin-stimulated glucose utilization. These models of body weight and glucose regulation adequately captured the experimental data and reflect significant physiological interactions among glucose, insulin, and FFA. These mechanism-based PD models provide further insights into the multi-factor control of this essential metabolic system. PMID:21394487

  13. Effect of dietary fiber in lowering serum glucose and body weight in sprague dawley rats

    Directory of Open Access Journals (Sweden)

    Muhammad Imran Chohan

    2011-08-01

    Full Text Available Introduction:The present study evaluated the hypoglycemic perspectives and weight loss significance of dietary fiber. Dietary fiber was supplemented in commercial wheat flour (atta for the preparation of chapaties, a staple diet of South Asia. Male Sprague Dawley rats (n = 100 were randomly divided into 4 diet groups (n = 25 per group. The control group was fed basal diet that included commercial wheat flour chapati, cornstarch, corn oil, salt and vitamin mixture in such a way that 10% of the protein was available from the final diet. To the basal diet of other 3 groups, chapaties supplemented with 2% guar gum (GG 2%, 3% guar gum (GG 3% and 5% chickpea + 1% guar gum (CP5%+GG1% were added, respectively. All diets were fed to the rats for a period of 8 weeks to perceive the impact of respective compositions. Rats fed on CP 5% + GG1%, showed maximum glucose reduction (14.57% followed by GG 3% (11.64% and GG 2% (9.60% as compared to control diet. Likewise, rats fed on 3% GG showed maximum decline (7.90% in body weight. It was concluded that chapaties prepared from selected treatments provide an additional dietary fiber that could be supportive for diabetic and obese individuals.Results:The results indicated that addition of dietary fiber influenced the physical characteristics of chapati non-significantly. Maximum glucose concentration was found to be 112.50 mg/dL in control group followed by 101.70 and 99.41 mg/dL in groups fed on guar gum 2% and guar gum 3%, respectively. Lowest glucose concentration (96.11 mg/dL was observed in rats fed on the combination of chickpea 5 %+ guar gum 1%. Maximum serum protein concentration was found to be 6.39 g/dL in rats fed on combination of chickpea 5 % + guar gum 1% whilst the remaining three groups showed non significant variations with respect to each other. Means for serum Functional Foods in Health and Disease 2011; 8:261-278 protein were 6.33, 6.30 and 6.32 g/dL for control, guar gum 3%, and guar gum 2

  14. Ultrasound: Which role in body composition?

    Science.gov (United States)

    Bazzocchi, Alberto; Filonzi, Giacomo; Ponti, Federico; Albisinni, Ugo; Guglielmi, Giuseppe; Battista, Giuseppe

    2016-08-01

    Ultrasound is a non-invasive, fast, relatively inexpensive and available tool for estimating adiposity in clinical practice, and in several research settings. It does not expose patients to ionizing radiation risks, making the method ideal for the evaluation, and for follow-up studies. Several parameters and indexes based on adipose tissue thickness have been introduced and tested, and these have been correlated with clinical and laboratoristic parameters. Moreover, ultrasound can also be directed to the estimation of adipose tissue and intracellular fat indirectly, at cellular-molecular level: an opportunity for many radiologists who already and sometimes unconsciously perform "body composition" assessment when looking at the liver, at muscle as well as at other organs. However, standardized procedure and parameters are needing to improve accuracy and reproducibility. The purposes of this review are: 1) to provide a complete overview of the most used and shared measurements of adiposity; 2) to analyze technical conditions, accuracy, and clinical meaning of ultrasound in the study of body composition; 3) to provide some elements for the use of ultrasound in the evaluation of intra-cellular lipids accumulation, in two hot spots: liver and skeletal muscle.

  15. Body composition in remission of childhood cancer

    Science.gov (United States)

    Tseytlin, G. Ja; Anisimova, A. V.; Godina, E. Z.; Khomyakova, I. A.; Konovalova, M. V.; Nikolaev, D. V.; Rudnev, S. G.; Starunova, O. A.; Vashura, A. Yu

    2012-12-01

    Here, we describe the results of a cross-sectional bioimpedance study of body composition in 552 Russian children and adolescents aged 7-17 years in remission of various types of cancer (remission time 0-15 years, median 4 years). A sample of 1500 apparently healthy individuals of the same age interval was used for comparison. Our data show high frequency of malnutrition in total cancer patients group depending on type of cancer. 52.7% of patients were malnourished according to phase angle and percentage fat mass z-score with the range between 42.2% in children with solid tumors located outside CNS and 76.8% in children with CNS tumors. The body mass index failed to identify the proportion of patients with malnutrition and showed diagnostic sensitivity 50.6% for obesity on the basis of high percentage body fat and even much less so for undernutrition - 13.4% as judged by low phase angle. Our results suggest an advantage of using phase angle as the most sensitive bioimpedance indicator for the assessment of metabolic alterations, associated risks, and the effectiveness of rehabilitation strategies in childhood cancer patients.

  16. Role of glucose and ketone bodies in the metabolic control of experimental brain cancer.

    Science.gov (United States)

    Seyfried, T N; Sanderson, T M; El-Abbadi, M M; McGowan, R; Mukherjee, P

    2003-10-06

    Brain tumours lack metabolic versatility and are dependent largely on glucose for energy. This contrasts with normal brain tissue that can derive energy from both glucose and ketone bodies. We examined for the first time the potential efficacy of dietary therapies that reduce plasma glucose and elevate ketone bodies in the CT-2A syngeneic malignant mouse astrocytoma. C57BL/6J mice were fed either a standard diet unrestricted (SD-UR), a ketogenic diet unrestricted (KD-UR), the SD restricted to 40% (SD-R), or the KD restricted to 40% of the control standard diet (KD-R). Body weights, tumour weights, plasma glucose, beta-hydroxybutyrate (beta-OHB), and insulin-like growth factor 1 (IGF-1) were measured 13 days after tumour implantation. CT-2A growth was rapid in both the SD-UR and KD-UR groups, but was significantly reduced in both the SD-R and KD-R groups by about 80%. The results indicate that plasma glucose predicts CT-2A growth and that growth is dependent more on the amount than on the origin of dietary calories. Also, restriction of either diet significantly reduced the plasma levels of IGF-1, a biomarker for angiogenesis and tumour progression. Owing to a dependence on plasma glucose, IGF-1 was also predictive of CT-2A growth. Ketone bodies are proposed to reduce stromal inflammatory activities, while providing normal brain cells with a nonglycolytic high-energy substrate. Our results in a mouse astrocytoma suggest that malignant brain tumours are potentially manageable with dietary therapies that reduce glucose and elevate ketone bodies.

  17. Lower Maternal Body Condition During Pregnancy Affects Skeletal Muscle Structure and Glut-4 Protein Levels But Not Glucose Tolerance in Mature Adult Sheep

    OpenAIRE

    Costello, Paula M.; Hollis, Lisa J.; Cripps, Roselle L.; Bearpark, Natasha; Patel, Harnish P.; Sayer, Avan Aihie; Cooper, Cyrus; Hanson, Mark A.; Ozanne, Susan E.; Lucy R Green

    2013-01-01

    Suboptimal maternal nutrition and body composition are implicated in metabolic disease risk in adult offspring. We hypothesized that modest disruption of glucose homeostasis previously observed in young adult sheep offspring from ewes of a lower body condition score (BCS) would deteriorate with age, due to changes in skeletal muscle structure and insulin signaling mechanisms. Ewes were fed to achieve a lower (LBCS, n = 10) or higher (HBCS, n = 14) BCS before and during pregnancy. Baseline pla...

  18. Body Composition at 3-years of Age

    DEFF Research Database (Denmark)

    Ejlerskov, Katrine Tschentscher

    are physiologically plausible and should be investigated in other study settings. Results from paper III showed that total and free IGF-I at both 9 and 36 months were positively related to most measures of anthropometry and body composition at 3 years. We found no clear associations between IGF-I levels and early...... development of obesity. It is possible that IGF-I levels are related to later risk of obesity through increased tempo of weight gain and linear growth leading to early adiposity rebound but this was not visible at 3 years. We had expected that intake of protein and cow’s milk was positively associated...... obesity risk is speculative. A continuation of the SKOT cohort with a follow-up visit when the children have reached 7 - 8 years of age would be highly relevant and enable further elaboration on the findings presented in paper II and III. At this age most children have passed the adiposity rebound...

  19. Insulin resistance, exercise capacity and body composition in subjects with two hypertensive parents

    DEFF Research Database (Denmark)

    Andersen, U B; Dige-Petersen, H; Ibsen, H

    1999-01-01

    for the difference between the means; -0.5; -7.9), but the insulin sensitivity index was similar: 312 versus 362 I(2) min(-1) pmol(-1) kg(-1) (28; -129). The two groups were similar in terms of body composition, exercise capacity and composition of usual diet. Resting and 24-h diastolic blood pressures were...... being highly selected as to confounding factors. The increased blood pressure in the hypertension prone subjects could not be attributed to differences in body composition, exercise capacity or dietary habits....... parents were both normotensive, were studied. Subjects or parents with diabetes and morbid obesity were excluded. METHODS: The study comprised (1) a frequent sampling oral glucose tolerance test; (2) an isoglycemic hyperinsulinemic clamp study; (3) an analysis of body composition by dual-energy X...

  20. Body composition and energy metabolism in elderly people.

    NARCIS (Netherlands)

    Visser, M.

    1995-01-01

    This thesis describes several studies related to the three components of energy balance in elderly people: body composition, energy expenditure, and energy intake.Body composition. The applicability of the body mass index, skinfold thickness method, and multi-frequency bioelectrical impedance was te

  1. Glucose sensing by carotid body glomus cells: potential implications in disease

    Directory of Open Access Journals (Sweden)

    Lin eGao

    2014-10-01

    Full Text Available The carotid body (CB is a key chemoreceptor organ in which glomus cells sense changes in blood O2, CO2, and pH levels. CB glomus cells have also been found to detect hypoglycemia in both non-primate mammals and humans. O2 and low-glucose responses share a common final pathway involving membrane depolarization, extracellular calcium influx, increase in cytosolic calcium concentration, and neurotransmitter secretion, which stimulates afferent sensory fibers to evoke sympathoadrenal activation. On the other hand, hypoxia and low glucose induce separate signal transduction pathways. Unlike O2 sensing, the response of the CB to low glucose is not altered by rotenone, with the low glucose-activated background cationic current unaffected by hypoxia. Responses of the CB to hypoglycemia and hypoxia can be potentiated by each other. The counter-regulatory response to hypoglycemia by the CB is essential for the brain, an organ that is particularly sensitive to low glucose. CB glucose sensing could be altered in diabetic patients, particularly those under insulin treatment, as well as in other medical conditions such as sleep apnea or obstructive pulmonary diseases, where chronic hypoxemia presents with plastic modifications in CB structure and function. The current review will focus on the following main aspects: 1 the CB as a low glucose sensor in both in vitro and in vivo models; 2 molecular and ionic mechanisms of low glucose sensing by glomus cells, 3 the interplay between low glucose and O2 sensing in CB, and 4 the role of CB low glucose sensing in the pathophysiology of cardiorespiratory and metabolic diseases, and how this may serve as a potential therapeutic target.

  2. Diet-induced thermogenesis and glucose oxidation in broiler chickens: influence of genotype and diet composition.

    Science.gov (United States)

    Swennen, Q; Janssens, G P J; Collin, A; Le Bihan-Duval, E; Verbeke, K; Decuypere, E; Buyse, J

    2006-04-01

    The main objectives of this study were to explore the role of diet-induced thermogenesis in the regulation of voluntary feed intake and to determine the glucose oxidation of broiler chicken strains, known to differ in glucose-insulin balance. From 2 to 7 wk of age, male broiler chickens of a fat and a lean line were reared on 1 of 2 isoenergetic diets with constant gross energy and carbohydrate levels but with substitutions between fat and protein. The low protein (LP/HF) diet contained 126 g of protein/kg and 106 g of fat/kg, whereas the low fat (LF/HP) diet contained 242 g of protein/kg and 43 g of fat/kg. There was no significant effect of the genetic background of the broilers on the glucose oxidation rate (as measured by stable isotope breath test) or protein oxidation (as measured by plasma uric acid levels). Considering the difference in carcass composition (fat content) of both lines, this leads to the hypothesis that the lines differ predominantly in fat metabolism. Although there was no line effect on plasma triglyceride and free fatty acid concentrations, it was hypothesized that there might be differences in fat oxidation or de novo lipogenesis, or both, between the genotypes. Diet-induced thermogenesis per metabolic body weight (kg of BW0.75) per 24 h, expressed per gram of feed intake, was not significantly influenced by genetic background or by diet composition. Therefore, a model linking feed intake to diet-induced thermogenesis, as postulated for adult mammals, could not be corroborated for growing broiler chickens.

  3. Fructose in Breast Milk Is Positively Associated with Infant Body Composition at 6 Months of Age.

    Science.gov (United States)

    Goran, Michael I; Martin, Ashley A; Alderete, Tanya L; Fujiwara, Hideji; Fields, David A

    2017-02-16

    Dietary sugars have been shown to promote excess adiposity among children and adults; however, no study has examined fructose in human milk and its effects on body composition during infancy. Twenty-five mother-infant dyads attended clinical visits to the Oklahoma Health Sciences Center at 1 and 6 months of infant age. Infants were exclusively breastfed for 6 months and sugars in breast milk (i.e., fructose, glucose, lactose) were measured by Liquid chromatography-mass spectrometry (LC-MS/MS) and glucose oxidase. Infant body composition was assessed using dual-energy X-ray absorptiometry at 1 and 6 months. Multiple linear regression was used to examine associations between breast milk sugars and infant body composition at 6 months of age. Fructose, glucose, and lactose were present in breast milk and stable across visits (means = 6.7 μg/mL, 255.2 μg/mL, and 7.6 g/dL, respectively). Despite its very low concentration, fructose was the only sugar significantly associated with infant body composition. A 1-μg/mL higher breast milk fructose was associated with a 257 g higher body weight (p = 0.02), 170 g higher lean mass (p = 0.01), 131 g higher fat mass (p = 0.05), and 5 g higher bone mineral content (p = 0.03). In conclusion, fructose is detectable in human breast milk and is positively associated with all components of body composition at 6 months of age.

  4. Fructose in Breast Milk Is Positively Associated with Infant Body Composition at 6 Months of Age

    Directory of Open Access Journals (Sweden)

    Michael I. Goran

    2017-02-01

    Full Text Available Dietary sugars have been shown to promote excess adiposity among children and adults; however, no study has examined fructose in human milk and its effects on body composition during infancy. Twenty-five mother–infant dyads attended clinical visits to the Oklahoma Health Sciences Center at 1 and 6 months of infant age. Infants were exclusively breastfed for 6 months and sugars in breast milk (i.e., fructose, glucose, lactose were measured by Liquid chromatography-mass spectrometry (LC-MS/MS and glucose oxidase. Infant body composition was assessed using dual-energy X-ray absorptiometry at 1 and 6 months. Multiple linear regression was used to examine associations between breast milk sugars and infant body composition at 6 months of age. Fructose, glucose, and lactose were present in breast milk and stable across visits (means = 6.7 μg/mL, 255.2 μg/mL, and 7.6 g/dL, respectively. Despite its very low concentration, fructose was the only sugar significantly associated with infant body composition. A 1-μg/mL higher breast milk fructose was associated with a 257 g higher body weight (p = 0.02, 170 g higher lean mass (p = 0.01, 131 g higher fat mass (p = 0.05, and 5 g higher bone mineral content (p = 0.03. In conclusion, fructose is detectable in human breast milk and is positively associated with all components of body composition at 6 months of age.

  5. Combination of the sodium-glucose cotransporter-2 inhibitor empagliflozin with orlistat or sibutramine further improves the body-weight reduction and glucose homeostasis of obese rats fed a cafeteria diet.

    Science.gov (United States)

    Vickers, Steven P; Cheetham, Sharon C; Headland, Katie R; Dickinson, Keith; Grempler, Rolf; Mayoux, Eric; Mark, Michael; Klein, Thomas

    2014-01-01

    The present study assessed the potential of the sodium glucose-linked transporter (SGLT)-2 inhibitor empagliflozin to decrease body weight when administered alone or in combination with the clinically effective weight-loss agents orlistat and sibutramine in obese rats fed a cafeteria diet. Female Wistar rats were exposed to a cafeteria diet to induce obesity. Empagliflozin was dosed once daily (10, 30, and 60 mg/kg) for 28 days. Combination studies were subsequently performed using a submaximal empagliflozin dose (10 mg/kg) with either sibutramine or orlistat. Body weight, food, and water intake were recorded daily. The effect of drug treatment on glucose tolerance, relevant plasma parameters, and carcass composition was determined. Empagliflozin dose-dependently reduced body weight, plasma leptin, and body fat though increased urinary glucose excretion. The combination of empagliflozin and orlistat significantly reduced body weight compared to animals treated with either drug alone, and significantly improved glucose tolerance, plasma insulin, and leptin compared to vehicle-treated controls. The effect of sibutramine to improve glycemic control in an oral glucose-tolerance test was also significantly increased, with empagliflozin and combination treatment leading to a reduction in carcass fat greater than that observed with either drug alone. These data demonstrate that empagliflozin reduces body weight in cafeteria-fed obese rats. In combination studies, empagliflozin further improved the body-weight or body-fat loss of animals in comparison to orlistat or sibutramine alone. Such studies may indicate improved strategies for the treatment of obese patients with prediabetes or type 2 diabetes.

  6. Combination of the sodium-glucose cotransporter-2 inhibitor empagliflozin with orlistat or sibutramine further improves the body-weight reduction and glucose homeostasis of obese rats fed a cafeteria diet

    Directory of Open Access Journals (Sweden)

    Vickers SP

    2014-07-01

    Full Text Available Steven P Vickers,1 Sharon C Cheetham,1 Katie R Headland,1 Keith Dickinson,1 Rolf Grempler,2 Eric Mayoux,2 Michael Mark,2 Thomas Klein2 1RenaSci, BioCity Nottingham, Nottingham, UK; 2Boehringer Ingelheim Pharma, Biberach an der Riss, Germany Abstract: The present study assessed the potential of the sodium glucose-linked transporter (SGLT-2 inhibitor empagliflozin to decrease body weight when administered alone or in combination with the clinically effective weight-loss agents orlistat and sibutramine in obese rats fed a cafeteria diet. Female Wistar rats were exposed to a cafeteria diet to induce obesity. Empagliflozin was dosed once daily (10, 30, and 60 mg/kg for 28 days. Combination studies were subsequently performed using a submaximal empagliflozin dose (10 mg/kg with either sibutramine or orlistat. Body weight, food, and water intake were recorded daily. The effect of drug treatment on glucose tolerance, relevant plasma parameters, and carcass composition was determined. Empagliflozin dose-dependently reduced body weight, plasma leptin, and body fat though increased urinary glucose excretion. The combination of empagliflozin and orlistat significantly reduced body weight compared to animals treated with either drug alone, and significantly improved glucose tolerance, plasma insulin, and leptin compared to vehicle-treated controls. The effect of sibutramine to improve glycemic control in an oral glucose-tolerance test was also significantly increased, with empagliflozin and combination treatment leading to a reduction in carcass fat greater than that observed with either drug alone. These data demonstrate that empagliflozin reduces body weight in cafeteria-fed obese rats. In combination studies, empagliflozin further improved the body-weight or body-fat loss of animals in comparison to orlistat or sibutramine alone. Such studies may indicate improved strategies for the treatment of obese patients with prediabetes or type 2 diabetes. Keywords

  7. Effects of Whole Body Vibration Training on Body Composition in Adolescents with Down Syndrome

    Science.gov (United States)

    Gonzalez-Aguero, Alejandro; Matute-Llorente, Angel; Gomez-Cabello, Alba; Casajus, Jose A.; Vicente-Rodriguez, German

    2013-01-01

    The present study aimed to determine the effect of 20 weeks of whole body vibration (WBV) on the body composition of adolescents with Down syndrome (DS). Thirty adolescent with DS were divided into two groups: control and WBV. Whole body, upper and lower limbs body fat and lean body mass were measured with dual energy X-ray absorptiometry (DXA)…

  8. Effects of Whole Body Vibration Training on Body Composition in Adolescents with Down Syndrome

    Science.gov (United States)

    Gonzalez-Aguero, Alejandro; Matute-Llorente, Angel; Gomez-Cabello, Alba; Casajus, Jose A.; Vicente-Rodriguez, German

    2013-01-01

    The present study aimed to determine the effect of 20 weeks of whole body vibration (WBV) on the body composition of adolescents with Down syndrome (DS). Thirty adolescent with DS were divided into two groups: control and WBV. Whole body, upper and lower limbs body fat and lean body mass were measured with dual energy X-ray absorptiometry (DXA)…

  9. Glycemic control and variability in association with body mass index and body composition over 18months in youth with type 1 diabetes.

    Science.gov (United States)

    Lipsky, Leah M; Gee, Benjamin; Liu, Aiyi; Nansel, Tonja R

    2016-10-01

    The impact of adiposity on glycemic control in type 1 diabetes patients has important implications for preventing complications. This study examined associations of glycemic outcomes with body mass index (BMI, kg/m(2)) and body composition in youth with type 1 diabetes. This is a secondary analysis of an 18-month randomized controlled dietary intervention trial (N=136, baseline age=12.3±2.5y, HbA1c=8.1±1.0% (65±11mmol/mol)). Measured height and weight every 3months were abstracted from medical records. Body composition was assessed by dual energy X-ray absorptiometry (DXA) at baseline, 12 and 18months. Glycated hemoglobin (HbA1c) and glycemic variability assessed by masked 3-day continuous blood glucose monitoring (CGM) were obtained every 3months. 1,5-Anhydroglucitol (1,5-AG) was assessed every 6months. Adjusted random effects models for repeated measures estimated associations of time-varying BMI and body composition with time-varying glycemic outcomes. There was no treatment effect on glycemic outcomes. HbA1c was not associated with BMI or body composition indicators. 1,5-AG was inversely associated with BMI and adiposity indicators (%fat, trunk fat mass and trunk %fat), adjusting for developmental covariates. Adiposity indicators were positively associated with %glucose >180mg/dL and >126mg/dL when adjusting for developmental covariates, and %glucose >126mg/dL when additionally adjusting for diabetes-related covariates. Fewer consistent relationships were observed for 3-day mean glucose and %glucose BMI and body composition variables were not associated with standard deviation of glycemic values or mean amplitude of glycemic excursions. The role of greater BMI and adiposity in diabetes management in youth with type 1 diabetes may relate specifically to increased hyperglycemic excursions. Published by Elsevier Ireland Ltd.

  10. Determination of body composition from skinfold thickness: a validation study.

    OpenAIRE

    Reilly, J J; Wilson, J.; Durnin, J V

    1995-01-01

    Measurement of body composition is proving increasingly important in clinical nutrition and research. Skinfold thickness is a simple means of estimating body composition which is widely used in children, but there is little information on its validity. There has been a proliferation of equations for estimation of body composition from skinfolds, but some doubt as to their general applicability. The aim of the present study was to validate five currently used equations for this purpose in a sa...

  11. Body Composition and Somatotype of Male and Female Nordic Skiers

    Science.gov (United States)

    Sinning, Wayne E.; And Others

    1977-01-01

    Anthropometric measurements (body composition and somatotype characteristics) for male and female Nordic skiers showed small values for measures of variance, suggesting that the subjects represented a select body type for the sport. (Author/MJB)

  12. Metabolic Rather Than Body Composition Measurements Are Associated With Lower Serum Natriuretic Peptide Concentrations in Normal Weight and Obese Men

    DEFF Research Database (Denmark)

    Asferg, Camilla L; Nielsen, Søren J; Andersen, Ulrik B

    2014-01-01

    men (BMI ≥ 30kg/m(2)), we determined body composition (total, android, and gynoid fat mass) by dual energy x-ray absorptiometry scanning, and we measured fasting serum concentrations of midregional proatrial NP (MR-proANP) and insulin, as well as fasting plasma glucose concentrations. RESULTS: Mean.......0001) and plasma glucose concentrations (β = -0.21; P = 0.02) but not with total (β = 0.00), android (β = -0.01), or gynoid (β = 0.03) fat mass percentage (P > 0.76). No significant interaction effects between metabolic measurements or body composition measurements and weight status on MR-proANP concentrations...

  13. Correlation between birth weight and maternal body composition.

    LENUS (Irish Health Repository)

    Kent, Etaoin

    2013-01-01

    To estimate which maternal body composition parameters measured using multifrequency segmental bioelectric impedance analysis in the first trimester of pregnancy are predictors of increased birth weight.

  14. Body composition in MesoAmerica.

    Science.gov (United States)

    Solomons, N W; Mazariegos, M

    1995-03-01

    The fundamental paradigm for the region is short stature. Adult height is on the order of 160 cm for men and 140 cm for women. The timing of this delayed growth has been fixed to the first two years of life, when as much as 2 Z-scores of stature may be loss to the median of the NCHS reference. In the elderly of the region, we have the issue of being initially short and then suffering further loss of stature with age. The height/armspan ratio has proven instructive for exploring that change in height with age. It appears to be less than in Europeans. Demands of a rigorous agricultural lifestyle, the energy content and density of the diet, and the ravages of recurrent infection and parasitism comprise the environmental determinants of body composition in poor MesoAmerican population. They are conducive to a low storage of fat, with lean body mass being subject to response to infections. Because of the basic short stature but muscular maturity of children and adults, one questions whether the assumptions of proportionality of weight for height from the NCHS reference data apply, or whether MesoAmericans should be normally greater in weight for height than a comparably short North American. For some at the lower end of the stature scale, no international reference standards actually exist for adults. All than can be measured with microtoise, calliper, flexible tape and balance has long been recorded in MesoAmerican populations. Certain high-cost and facility- dependent technologies, such as nuclear magnetic resonance imaging and whole-body neutron activation analysis, are beyond the scientific economies of any part of the region. Dual energy x-ray absorbitometry instruments are available for clinical diagnosis in Mexico, Guatemala and Costa Rica, and could be turned to research ends. Underwater weighing has been practiced variously in MesoAmerica. Researchers in Guatemala have pioneered in the investigative use of bioelectrical impedance analysis to all ages from low

  15. REVIEW: Development of methods for body composition studies

    Science.gov (United States)

    Mattsson, Sören; Thomas, Brian J.

    2006-07-01

    This review is focused on experimental methods for determination of the composition of the human body, its organs and tissues. It summarizes the development and current status of fat determinations from body density, total body water determinations through the dilution technique, whole and partial body potassium measurements for body cell mass estimates, in vivo neutron activation analysis for body protein measurements, dual-energy absorptiometry (DEXA), computed tomography (CT) and magnetic resonance imaging (MRI, fMRI) and spectroscopy (MRS) for body composition studies on tissue and organ levels, as well as single- and multiple-frequency bioimpedance (BIA) and anthropometry as simple easily available methods. Methods for trace element analysis in vivo are also described. Using this wide range of measurement methods, together with gradually improved body composition models, it is now possible to quantify a number of body components and follow their changes in health and disease.

  16. Modification of corporal weight, body fat distribution, blood lipids and glucose levels in oral contraceptive users.

    Science.gov (United States)

    Carranza-Lira, S; Bueno Fontal, J P

    2000-01-01

    The association between oral contraceptives and the modification of corporal weight and body fat distribution is controversial. The characteristics of the menstrual cycle, lipids and glucose levels were also analyzed. Thirty women who received ethinylestradiol 0.035 mg and norethindrone 0.400 mg for one year were studied. The following variables were analyzed every 3 months: weight, body mass index (BMI), hip perimeter, waist perimeter, waist-hip ratio (WHR), duration of menstrual cycle, quantity of uterine bleeding, as well as blood levels of cholesterol, triglycerides and glucose. Waist and hip perimeters increased during the third evaluation; as well as the BMI starting from the second evaluation. The triglycerides levels rose from the first evaluation. No modifications were found in the WHR, glucose and cholesterol levels and the duration of the menstrual cycle, but the quantity of uterine bleeding decreased from the third month. The oral contraceptive significantly increased BMI and triglycerides level, but no changes were detected in body fat distribution, cholesterol and glucose levels. Uterine bleeding decreased from the first evaluation.

  17. Body image, body mass index, and body composition in young adults.

    Science.gov (United States)

    Streeter, Veronica M; Milhausen, Robin R; Buchholz, Andrea C

    2012-01-01

    Associations were examined between body image and body mass index (BMI) in comparison with body composition in healthy weight, overweight, and obese young adults. Weight and height were determined, and the percentage of fat mass (%FM) and percentage of fat-free mass (%FFM) were measured by dual energy X-ray absorptiometry in 75 male and 87 female young adults (21.1 ± 1.9 years; 25.2 ± 4.4 kg/m² [mean ± standard deviation]). Body image was measured using the three subscales Weight Esteem, Appearance Esteem, and External Attribution of the Body-Esteem Scale for Adolescents and Adults (BESAA). Body mass index and %FM were highly correlated (r for males = 0.74, r for females = 0.82; both pbody image, particularly Weight Esteem. After adjustment for physical activity, BMI and %FM (and %FFM, although in the opposite direction) were associated with each BESAA subscale: %FM, %FFM, and BMI explained 12% to 14% of the variance in Appearance Esteem for both sexes, 33% to 41% in Weight Esteem in women and 16% to 18% in men, and 8% to 10% in External Attribution in women (all pbody image decreases, particularly in women.

  18. Effects of resistance training on binge eating, body composition and blood variables in type II diabetics

    Directory of Open Access Journals (Sweden)

    Moisés Simão Santa Rosa de Sousa

    2014-03-01

    This study examined the effects of 12 weeks of resistance training (RT on binge eating, body composition and blood variables and their correlations in 34 sedentary adults with type II diabetes. The participants aged 58.94 ± 10.66, had body weight of 71.62 ± 11.85 and BMI of 29.64 ± 4.27. Blood samples were collected for analysis of serum leptin, glucose, insulin, LDL, HDL, total cholesterol and triglyceride. The binge eating was assessed by the binge eating scale and the body composition by bioelectrical impedance. The training included three weekly sessions for 12 weeks, with three sets from 12 to 15 repetitions for the main muscle groups, and interval from 1 to 2 minutes between the sets. A significant decrease was found for the binge eating, body weight, BMI, fat percentage, and fat weight. As for the blood variables, there was a significant reduction in leptin; non-significant reductions in glucose, total cholesterol, LDL and triglycerides; as well a significant increase in HDL and non-significant increase in insulin. In conclusion the 12 weeks of RT proved to be enough to decrease the binge eating, to positively adjust the body composition and to modify the blood profile, demonstrating an association at a lower or higher level between these variables.

  19. Fructose-Glucose Composite Carbohydrates and Endurance Performance: Critical Review and Future Perspectives.

    Science.gov (United States)

    Rowlands, David S; Houltham, S; Musa-Veloso, K; Brown, F; Paulionis, L; Bailey, D

    2015-11-01

    Sports beverages formulated with fructose and glucose composites enhance exogenous carbohydrate oxidation, gut comfort, and endurance performance, relative to single-saccharide formulations. However, a critical review of performance data is absent. We conducted a comprehensive literature review of the effect of fructose:glucose/maltodextrin (glucose or maltodextrin) composites versus glucose/maltodextrin on endurance performance. Mechanistic associations were drawn from effects on carbohydrate metabolism, gut, and other sensory responses. Overall, 14 studies contained estimates of 2.5-3.0-h endurance performance in men, mostly in cycling. Relative to isocaloric glucose/maltodextrin, the ingestion of 0.5-1.0:1-ratio fructose:glucose/maltodextrin beverages at 1.3-2.4 g carbohydrate·min(-1) produced small to moderate enhancements (1-9 %; 95 % confidence interval 0-19) in mean power. When 0.5:1-ratio composites were ingested at ≥1.7 g·min(-1), improvements were larger (4-9 %; 2-19) than at 1.4-1.6 g·min(-1) (1-3 %; 0-6). The effect sizes at higher ingestion rates were associated with increased exogenous carbohydrate oxidation rate, unilateral fluid absorption, and lower gastrointestinal distress, relative to control. Solutions containing a 0.7-1.0:1 fructose:glucose ratio were absorbed fastest; when ingested at 1.5-1.8 g·min(-1), a 0.8:1 fructose:glucose ratio conveyed the highest exogenous carbohydrate energy and endurance power compared with lower or higher fructose:glucose ratios. To conclude, ingesting 0.5-1.0:1-ratio fructose:glucose/maltodextrin beverages at 1.3-2.4 g·min(-1) likely benefits 2.5-3.0 h endurance power versus isocaloric single saccharide. Further ratio and dose-response research should determine if meaningful performance benefits of composites accrue with ingestion carbohydrate demands may differ from the current analysis.

  20. Coronary microvascular function, insulin sensitivity and body composition in predicting exercise capacity in overweight patients with coronary artery disease

    DEFF Research Database (Denmark)

    Jürs, Anders; Pedersen, Lene Rørholm; Olsen, Rasmus Huan

    2015-01-01

    BACKGROUND: Coronary artery disease (CAD) has a negative impact on exercise capacity. The aim of this study was to determine how coronary microvascular function, glucose metabolism and body composition contribute to exercise capacity in overweight patients with CAD and without diabetes. METHODS......: Sixty-five non-diabetic, overweight patients with stable CAD, BMI 28-40 kg/m(2) and left ventricular ejection fraction (LVEF) above 35 % were recruited. A 3-hour oral glucose tolerance test was used to evaluate glucose metabolism. Peak aerobic exercise capacity (VO2peak) was assessed...... by a cardiopulmonary exercise test. Body composition was determined by whole body dual-energy X-ray absorptiometry scan and magnetic resonance imaging. Coronary flow reserve (CFR) assessed by transthoracic Doppler echocardiography was used as a measure of microvascular function. RESULTS: Median BMI was 31.3 and 72...

  1. Somatotype and Body Composition of Normal and Dysphonic Adult Speakers

    OpenAIRE

    Franco, Débora; Fragoso, Isabel; Andrea, Mário; Teles,Júlia; Martins, Fernando

    2016-01-01

    Voice quality provides information about the anatomical characteristics of the speaker. The patterns of somatotype and body composition can provide essential knowledge to characterize the individuality of voice quality. The aim of this study was to verify if there were significant differences in somatotype and body composition between normal and dysphonic speakers.

  2. Peer Victimisation and Its Relationships with Perceptions of Body Composition

    Science.gov (United States)

    Frisen, Ann; Lunde, Carolina; Hwang, Philip

    2009-01-01

    The present study examined the links between children's exposure to peer victimisation, in terms of type and frequency, their body composition and subjective perceptions of body composition. A total of 960 Swedish 10-year-olds (515 girls and 445 boys) completed questionnaires about their peer victimisation experiences, weight and height, and…

  3. Growth, feed intake and body composition of ostriches (Struthio ...

    African Journals Online (AJOL)

    different patterns of energy intake, growth rate, feed conversion ratio, body composition and the composition of ... was closely related to deposition rate of body fat and inversely related to energy loss as heat expenditure. ... of feed to animal tissue is expressed ... The diet was initially formulated according to poultry values.

  4. Tumor glucose metabolism imaged in vivo in small animals with whole-body photoacoustic computed tomography

    Science.gov (United States)

    Chatni, Muhammad Rameez; Xia, Jun; Sohn, Rebecca; Maslov, Konstantin; Guo, Zijian; Zhang, Yu; Wang, Kun; Xia, Younan; Anastasio, Mark; Arbeit, Jeffrey; Wang, Lihong V.

    2012-07-01

    With the increasing use of small animals for human disease studies, small-animal whole-body molecular imaging plays an important role in biomedical research. Currently, none of the existing imaging modalities can provide both anatomical and glucose molecular information, leading to higher costs of building dual-modality systems. Even with image co-registration, the spatial resolution of the molecular imaging modality is not improved. Utilizing a ring-shaped confocal photoacoustic computed tomography system, we demonstrate, for the first time, that both anatomy and glucose uptake can be imaged in a single modality. Anatomy was imaged with the endogenous hemoglobin contrast, and glucose metabolism was imaged with a near-infrared dye-labeled 2-deoxyglucose.

  5. Assessing body composition: the skinfold method.

    Science.gov (United States)

    Talbot, L A; Lister, Z

    1995-12-01

    1. Excess body fat contributes to many chronic diseases. Using a case scenario, an initial screening assessment is performed on two clients. The occupational health nurse provides feedback on current lifestyle behaviors and educates the clients about relevant lifestyle changes. 2. Tables illustrate the step by step procedures for measuring body fat using the skinfold thickness method. Photographs show the multiple body sites used in the skinfold analysis. 3. Commonly asked client questions related to body fat are discussed in detail, and the use of body fat assessment as a screening method for the health promotion professional is described.

  6. Impact of diet composition on blood glucose regulation

    NARCIS (Netherlands)

    Russell, W.R.; Baka, A.; Bjorck, I.; Delzenne, N.; Gao, D.; Griffiths, H.R.; Hadjilucas, E.; Juvonen, K.; Lahtinen, S.; Lansink, M.; van Loon, L.; Mykkanen, H.; Ostman, E.; Riccardi, G.; Vinoy, S.; Weickert, M.O.

    2013-01-01

    Abstract Nutritional management of blood glucose levels is a strategic target in the prevention and management of type 2 diabetes mellitus (T2DM). To implement such an approach it is essential to understand the effect of food on glycaemic regulation and on the underlying metabolic derangements. This

  7. Body composition and dietary intake in neoplasic disease

    Energy Technology Data Exchange (ETDEWEB)

    Cohn, S.H. (Brookhaven National Lab., Upton, NY); Gartenhaus, W.; Vartsky, D.; Sawitsky, A.; Zanzi, I.; Vaswani, A. Yasummure, S.; Rai, K.; Cartes, E.; Ellis, K.J.

    1981-10-01

    Changes in body composition in 37 cancer patients were studied over a period of 6 months. Initially, the patients were divided into two groups: those who lost body weight (over 10%) and those who maintained or gained body weight before the study. Analysis of body composition indicated that patients who lost body weight has caloric and protein intakes markedly below ''normal'' levels at the beginning of the study. There also appears to be a direct relationship between the protein intake and the total body potassium/total body water ratio in the cancer patients. At the end of the 6-month study, the patients were again placed into two groups on the basis of weight loss or gain (and maintenance). Changes in body composition over the period were analyzed in terms of lean body mass, its protein constituent, water, and fat. Weight loss was found to reflect primarily the loss of fat, water, lean body mass (potassium), and only to a minor extent the protein component of lean body mass (nitrogen). Further, on the basis of the values of the ratios of total body nitrogen/total body potassium/total body water, it was possible to ascertain the relative normalcy of the body tissue gained or lost in the 6-month period. The results of the study suggest that the ratio total body nitrogen/total body potassium may serve as the best indicator of recent or ongoing catabolism or anabolism of the neoplastic process. By means of the application of the techniques used for the determination of body composition, it should be possible to assess regimes of hyperalimentation of cancer patients who lose body weight. (JMT)

  8. Acute effects of growth hormone on metabolism of pancreatic hormones, glucose and ketone bodies.

    Science.gov (United States)

    Okuda, Y; Peña, J; Chou, J; Field, J B

    2001-07-01

    Controversy exists as to whether acute administration of growth hormone has insulin-like effects. In conscious dogs, acute effects on plasma flows, plasma glucose, hepatic glucose output, free fatty acids, ketone bodies, insulin, and glucagon were determined following intravenous injection of 1 mg of growth hormone extracted from the canine pituitary gland. The following results were obtained: (1) Plasma flows in the portal vein, hepatic artery and hepatic vein were significantly increased 20 min after growth hormone administration. (2) By 40 min after growth hormone, the glucose concentration in these three vessels was significantly increased. (3) Hepatic glucose output was significantly increased 60 min after growth hormone administration. (4) Free fatty acids levels were significantly but transiently increased at 20 min, while ketone body concentrations were elevated at 120-180 min. (5) The insulin levels in the three vessels demonstrated a biphasic response. In the portal vein, they were significantly higher 20 min after growth hormone and again at 150-180 min. Glucagon concentrations were increased in all three vessels by 20 min and remained elevated for the remainder of the experiment. These results do not support an acute insulin-like action of growth hormone in normal dogs.

  9. Body composition and perception of teenagers from public schools

    Directory of Open Access Journals (Sweden)

    Ana Paula Araújo Ferreira

    2013-10-01

    Full Text Available Adolescence is accompanied by cognitive, emotional, social and biological changes; situations that increase the risk for development of psychosomatic disorders. This study measured and classified body composition and compared it to body self-perception in adolescents. Students from the seventh to ninth grade in public primary education in Distrito Federal, Brazil, answered socio-demographic and body self-perception questionnaires. Weight and height were measured and body mass index (BMI was calculated for body composition classification. From the 977 adolescents, 79.1% presented eutrophic BMI. Of the 473 boys, 11.4% were overweight and 4.7% underweight, 23.8% perceived the body as smaller than it really is and 25.5% tried to gain body mass. Of the 504 girls, 11.9% were overweight and 13.4% underweight, 24.1% perceived the body as larger than it really is and 32.5% tried to lose body mass. Inadequate body composition, prevalent in 20.9% of adolescents, may harm growth, development and health. These problems may be aggravated by the high prevalence of distorted body self-perception and attitudes for bodily changes. It is recommended the implementation of educational interventions on body composition, perception and culture and health, with different approaches by gender.

  10. Copper-decorated carbon nanotubes-based composite electrodes for nonenzymatic detection of glucose

    NARCIS (Netherlands)

    Pop, A.; Manea, F.; Orha, C.; Motoc, S.; Llinoiu, E.; Vaszilcsin, N.; Schoonman, J.

    2012-01-01

    The aim of this study was to prepare three types of multiwall carbon nanotubes (CNT)-based composite electrodes and to modify their surface by copper electrodeposition for nonenzymatic oxidation and determination of glucose from aqueous solution. Copper-decorated multiwall carbon nanotubes composite

  11. Effect of physical activity on body composition

    Energy Technology Data Exchange (ETDEWEB)

    Zanzi, I; Ellis, K J; Aloia, J; Cohn, S H

    1980-01-01

    It has been noted that the deleterious effects on bone calcium of prolonged periods of inactivity, such as bed rest, are halted following resumption of activity. It would seem possible in light of the observations that have been made, that exercise may stimulate bone formation and perhaps counter, to some extent, bone loss as observed in the osteoporosis of aging. The present study was designed to determine the relation between total body calcium, total body potassium and bone mineral content of the radius to the degree of physical activity in a population of normal subjects. Measurement of the calcium was made by in-vivo total body neutron activation analysis. Bone mineral content of the radius and total body potassium, (an index of lean body mass) were measured by photon absorptiometry and the whole body counter, respectively.

  12. Body composition changes after transjugular intrahepatic portosystemic shunt in patients with cirrhosis

    Institute of Scientific and Technical Information of China (English)

    Jonathan; Montomoli; Peter; Holland-Fischer; Giampaolo; Bianchi; Henning; GrФnbk; Hendrik; Vilstrup; Giulio; Marchesini; Marco; Zoli

    2010-01-01

    AIM:To investigate the effect of transjugular intra-hepatic porto-systemic shunt (TIPS) on malnutrition in portal hypertensive cirrhotic patients.METHODS: Twenty-one patients with liver cirrhosis and clinical indications for TIPS insertion were investigated before and 1, 4, 12, 52 wk after TIPS. For each patient we assayed body composition parameters [dry lean mass, fat mass, total body water (TBW)], routine liver and kidney function tests, and free fatty acids (FFA). Glucose and insulin were measured for t...

  13. Biostable glucose permeable polymer

    DEFF Research Database (Denmark)

    2017-01-01

    A new biostable glucose permeable polymer has been developed which is useful, for example, in implantable glucose sensors. This biostable glucose permeable polymer has a number of advantageous characteristics and, for example, does not undergo hydrolytic cleavage and degradation, thereby providing...... a composition that facilitates long term sensor stability in vivo. The versatile characteristics of this polymer allow it to be used in a variety of contexts, for example to form the body of an implantable glucose sensor. The invention includes the polymer composition, sensor systems formed from this polymer...

  14. Effect of intense military training on body composition.

    Science.gov (United States)

    Malavolti, Marcella; Battistini, Nino C; Dugoni, Manfredo; Bagni, Bruno; Bagni, Ilaria; Pietrobelli, Angelo

    2008-03-01

    Individuals in a structural physical training program can show beneficial changes in body composition, such as body fat reduction and muscle mass increase. This study measured body composition changes by using 3 different techniques-skinfold thickness (SF) measurements, air displacement plethysmography (BOD-POD), and dual-energy x-ray absorptiometry (DXA)-during 9 months of intense training in healthy young men engaged in military training. Twenty-seven young men were recruited from a special faction of the Italian Navy. The program previewed three phases: ground combat, sea combat, and amphibious combat. Body composition was estimated at the beginning, in the middle, and at the end of the training. After the subjects performed the ground combat phase, body composition variables significantly decreased: body weight (P BOD-POD (P = 0.90) and DXA was significantly greater than measured by SF. A significant difference was found in body mass index (BMI) measured during the study. BOD-POD and SF, compared with DXA, provide valid and reliable measurement of changes in body composition in healthy young men engaged in military training. In conclusion, the findings suggest that for young men of normal weight, changes in body weight alone and in BMI are not a good measure to assess the effectiveness of intense physical training programs, because lean mass gain can masquerade fat weight loss.

  15. Sex differences in glucose levels

    DEFF Research Database (Denmark)

    Faerch, K; Borch-Johnsen, Knut; Vaag, A

    2010-01-01

    We aimed to examine whether sex differences in fasting plasma glucose (FPG), 2 h post-OGTT plasma glucose (2hPG) and HbA(1c) could be explained by differences in body size and/or body composition between men and women in a general non-diabetic Danish population. Moreover, we aimed to study to what...

  16. Electrochemical activity of glucose oxidase on a poly(ionic liquid)-Au nanoparticle composite.

    Science.gov (United States)

    Lee, Sungwon; Ringstrand, Bryan S; Stone, David A; Firestone, Millicent A

    2012-05-01

    Glucose oxidase (GOx) adsorbed on an ionic liquid-derived polymer containing internally organized columns of Au nanoparticles exhibits direct electron transfer and bioelectrocatalytic properties towards the oxidation of glucose. The cationic poly(ionic liquid) provides an ideal substrate for the electrostatic immobilization of GOx. The encapsulated Au nanoparticles serve to both promote the direct electron transfer with the recessed enzyme redox centers and impart electronic conduction to the composite, allowing it to function as an electrode for electrochemical detection.

  17. Body composition estimations by BIA versus anthropometric equations in body builders and other power athletes.

    Science.gov (United States)

    Huygens, W; Claessens, A L; Thomis, M; Loos, R; Van Langendonck, L; Peeters, M; Philippaerts, R; Meynaerts, E; Vlietinck, R; Beunen, G

    2002-03-01

    Two main questions are stated: 1) are BIA and anthropometric equations accurate in estimating body composition in male power athletes and more specifically in body builders and 2) is there a difference in body composition when body builders are compared to weight and power lifters? this is a descriptive, comparative study on a selected sample of power athletes. 49 Belgian elite and sub-top male power athletes (34 body builders and 15 weight and power lifters) were included in this sample. More than 70% was in preparation of competition at time of data collection. an extended set of anthropometric measures was taken. Body composition was estimated by BIA (Bioelectrical Impedance Analysis) and by regression equations of skinfolds. Somatotype and muscle+bone areas were calculated. Factor analysis on all anthropometric measures was carried out to determine the body structure of the athletes. Compared to external visual criteria, the equations of Durnin and Womersley and Lohman (skinfolds) and the Guo-equation (BIA) were the only equations that could accurately estimate the body composition for this specific group of athletes. However, the sum of skinfolds attains the most accurate estimate of subcutaneous fatness. Body builders have significantly (pathletes (5.9 vs 3.8). This study shows that to estimate body composition in extreme power athletes BIA is not as accurate as compared to anthropometric equations. Moreover, the sum of a larger set of skinfolds is preferred to anthropometric prediction equations. In addition, body builders are more muscular and leaner than other power athletes.

  18. Physiological models of body composition and human obesity

    Directory of Open Access Journals (Sweden)

    Shapses Sue A

    2007-09-01

    Full Text Available Abstract Background The body mass index (BMI is the standard parameter for predicting body fat fraction and for classifying degrees of obesity. Currently available regression equations between BMI and fat are based on 2 or 3 parameter empirical fits and have not been validated for highly obese subjects. We attempt to develop regression relations that are based on realistic models of body composition changes in obesity. These models, if valid, can then be extrapolated to the high fat fraction of the morbidly obese. Methods The analysis was applied to 3 compartment (density and total body water measurements of body fat. The data was collected at the New York Obesity Research Center, Body Composition Unit, as part of ongoing studies. A total of 1356 subjects were included, with a BMI range of 17 to 50 for males and 17 to 65 for females. The body composition model assumes that obese subjects can be represented by the sum of a standard lean reference subject plus an extra weight that has a constant adipose, bone and muscle fraction. Results There is marked age and sex dependence in the relationship between BMI and fat fraction. There was no significant difference among Caucasians, Blacks and Hispanics while Asians had significantly greater fat fraction for the same BMI. A linear relationship between BMI and fat fraction provides a good description for men but overestimates the fat fraction in morbidly obese women for whom a non-linear regression should be used. New regression relations for predicting body fat just from experimental measurements of body density are described that are more accurate then those currently used. From the fits to the experimental BMI and density data, a quantitative description of the bone, adipose and muscle body composition of lean and obese subjects is derived. Conclusion Physiologically realistic models of body composition provide both accurate regression relations and new insights about changes in body composition in

  19. Comparison of the effectiveness of body mass index and body fat percentage in defining body composition.

    Science.gov (United States)

    Goonasegaran, Arvin Raj; Nabila, Fatin Nabila; Shuhada, Nurul Shuhada

    2012-06-01

    Body mass index (BMI) has limited diagnostic performance due to its inability to discriminate between fat and lean mass. This study was conducted to compare the effectiveness of body fat percentage (BFP) against BMI in defining body composition. A cross-sectional study was conducted on students aged 17-30 years in Melaka, Malaysia. Basic anthropometric measurements were acquired using a manual weighing scale, measuring tape and a fixed stadiometer. BFP was calculated using the United States Navy formula. Data was tabulated and analysed using Epi Info and Statistical Package for the Social Sciences software. Pearson's correlation coefficient and Kappa values were used. A p-value < 0.05 was considered statistically significant. Out of the 490 subjects recruited, 43% of males and 24.6% of females were found to be overweight, while 14.3% of males and 7.8% of females were obese, when calculated using BMI. However, 8.9% of males and 22.8% of females were considered obese based on the BFP. BFP plays a more important role in distinguishing between healthy and obese individuals, as it has a greater ability to differentiate between lean mass and fat mass compared to BMI.

  20. Abomasal amino acid infusion in postpartum dairy cows: Effect on whole-body, splanchnic, and mammary glucose metabolism

    DEFF Research Database (Denmark)

    Galindo, C; Larsen, Mogens; Ouellet, D R

    2015-01-01

    Nine Holstein cows fitted with rumen cannulas and indwelling catheters in splanchnic blood vessels were used to study the effects of supplementing AA on milk lactose secretion, whole-body rate of appearance (WB-Ra) of glucose, and tissue metabolism of glucose, lactate, glycerol, and β-OH-butyrate...

  1. EFFECTS OF WHOLE BODY RESISTANCE TRAINING ON BONE STATUS AND BODY COMPOSITION IN YOUNG FEMALES

    Directory of Open Access Journals (Sweden)

    Yılmaz

    2014-12-01

    Full Text Available The purpose of this study was to determine the effects of whole body resistance training on bone status and body composition in young female. Twenty five moderately active females volunteered to participate in this study and were randomly assigned to whole body resistance trained (WRT (n=13; 23.1±2.0 years and control (C groups (n=12; 22.5±1.7 years. Height, body weight and body composition measurements were held. Total body fat (%BF, fat mass (FM, fat-free mass (FFM, and bone mineral density (BMD measurements were performed with dual-energy X-ray absorptiometry. After completing the pre-test measurements, the WRT subjects were participated in 12 week whole body resistance training. At the end of the 12-week training period, paired t-test results showed that there was a significant (p.05 change in the body weight (-.21kg or BMI (.09. In the control group, significant (p.05 change in the body weight (.85kg, FFM (.12kg, and BMD (-.002 g/cm2 after 12 week period. These results showed that 12 week whole body resistance training had a optimize effect on body composition and bone status, but had no effect on body weight and body mass index in young female subjects.

  2. Influence of orlistat on bone turnover and body composition

    DEFF Research Database (Denmark)

    Gotfredsen, A; Westergren Hendel, H; Andersen, T

    2001-01-01

    OBJECTIVE: To investigate the influence of the pancreas lipase inhibitor orlistat (OLS) on calcium metabolism, bone turnover, bone mass, bone density and body composition when given for obesity as adjuvant to an energy- and fat-restricted diet. DESIGN: Randomized controlled double-blinded trial...... of treatment with OLS 120 mg three times daily or placebo for 1 y. SUBJECTS: Thirty obese subjects with a mean body mass index (BMI) of 36.9+/-3.7 kg/m(2) and a mean age of 41+/-11 y. Sixteen patients were assigned to OLS and 14 to placebo. MEASUREMENTS: Dual energy X-ray absorptiometry (DXA) measurements...... of bone mineral and body composition included total bone mineral content (TBMC), total bone mineral density (TBMD), lumbar spine BMC and BMD, forearm BMC and BMD, fat mass (FM), fat free-mass (FFM), percentage fat mass (FM%) as well as a DXA estimate of the body weight. Body composition (FM, FFM and FM...

  3. Body composition and risk for metabolic alterations in female adolescents

    OpenAIRE

    Eliane Rodrigues de Faria; Cristiana Araújo Gontijo; Franceschini, Sylvia do Carmo C.; Maria do Carmo G. Peluzio; Silvia Eloiza Priore

    2014-01-01

    OBJECTIVE: To study anthropometrical and body composition variables as predictors of risk for metabolic alterations and metabolic syndrome in female adolescents. METHODS: Biochemical, clinical and corporal composition data of 100 adolescents from 14 to 17 years old, who attended public schools in Viçosa, Southeastern Brazil, were collected. RESULTS: Regarding nutritional status, 83, 11 and 6% showed eutrophia, overweight/obesity and low weight, respectively, and 61% presented high body fat pe...

  4. Injury frequency and body composition of elite Romanian rugby players

    OpenAIRE

    Bogdan ALMĂJAN-GUȚĂ; Alexandra-Mihaela RUSU; Adrian NAGEL; Claudiu AVRAM

    2017-01-01

    Background: The physical exertion in the game of rugby is intense and depends on the playing position. This study hypothesized that peculiarities of body composition are important and should be properly interpreted in order to improve fitness and particularly in order to reduce the risk of injuries. Purpose: The aim of the present paper is to highlight the importance of body composition evaluation and to underline the usefulness of the data thus obtained for both training individualization an...

  5. Anthropometric predictive equations for estimating body composition

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Salamat

    2015-01-01

    Conclusions: Combinations of anthropometric measurements predict whole-body lean mass and trunk fat mass better than any of these single anthropometric indices. Therefore, the findings of the present study may be used to verify the results in patients with various diseases or diets.

  6. The interplay between nutrition and body composition

    African Journals Online (AJOL)

    or radiation treatment for cancer.3.4 The loss of body tissue may be ... observed in surviving patients, while BCM remained low in those with .... in terminal patients. One may ..... chronic obstr1JClive lung disease and acute respiratory failure.

  7. Feed intake, live mass-gain, body composition and protein ...

    African Journals Online (AJOL)

    Feed intake, live mass-gain, body composition and protein deposition in pigs fed ... of 82 genetically lean and 90 obese Landrace pigs was allotted to three dietary ... Diets were fed ad libitum from 8 weeks of age up to slaughter for whole body ...

  8. Human body composition models and methodology: theory and experiment.

    NARCIS (Netherlands)

    Wang, Z.M.

    1997-01-01

    The study of human body composition is a branch of human biology which focuses on the in vivo quantification of body components, the quantitative relationships between components, and the quantitative changes in these components related to various influencing factors. Accordingly, the study of human

  9. Human body composition models and methodology : theory and experiment

    NARCIS (Netherlands)

    Wang, Z.M.

    1997-01-01


    The study of human body composition is a branch of human biology which focuses on the in vivo quantification of body components, the quantitative relationships between components, and the quantitative changes in these components related to various influencing factors.

  10. Effects of Cooling and Supplemental Bovine Somatotropin on Milk Production relating to Body Glucose Metabolism and Utilization of Glucose by the Mammary Gland in Crossbred Holstein Cattle

    Directory of Open Access Journals (Sweden)

    Siravit Sitprija

    2010-01-01

    Full Text Available Problem statement: The low milk yield and shorter persistency of lactation of dairy cattle is the major problem for the dairy practices in the tropics. High environmental temperatures and rapid decline of plasma growth hormone level can influence milk production. Regulation of the milk yield of animals is mainly based on the mechanisms governing the quantity of glucose extracted by the mammary gland for lactose biosynthetic pathways. The mechanism(s underlying the effects of cooling and supplemental bovine somatotropin on milk production relating to body glucose metabolism and intracellular metabolism of glucose in the mammary gland of crossbred Holstein cattle in the tropics have not been investigated to date. Approach: Ten crossbred 87.5% Holstein cows were divided into two groups of five animals each. Animals were housed in Normal Shade barn (NS as non-cooled cows and cows in the second group were housed in barn which was equipped with a two Misty-Fan cooling system (MF as cooled cows. Supplementation of recombinant bovine Somatotropin (rbST (POSILAC, 500 mg per cow were performed in both groups to study body glucose metabolism and the utilization of glucose in the mammary gland using a continuous infusion of [3-3H] glucose and [U- 14C] glucose as markers in early, mid and late stages of lactation. Results: Milk yield significantly increased in both groups during supplemental rbST with a high level of mammary blood flow. Body glucose turnover rates were not significant different between cooled and non-cooled cows whether supplemental rbST or not. The glucose taken up by the mammary gland of both non-cooled and cooled cows increased flux through the lactose synthesis and the pentose cycle pathway with significant increases in NADPH formation for fatty acid synthesis during rbST supplementation. The utilization of glucose carbon incorporation into milk appeared to increase in milk lactose and milk triacylglycerol but not for

  11. Body composition in patients with schizophrenia: Comparison with healthy controls

    Directory of Open Access Journals (Sweden)

    Sugawara Norio

    2012-05-01

    Full Text Available Abstract Background Recently, a relationship between obesity and schizophrenia has been reported. Although fat- mass and fat free mass have been shown to be more predictive of health risk than body mass index, there are limited findings about body composition among patients suffering from schizophrenia. The aim of this study is to compare the body composition of schizophrenia patients with that of healthy subjects in Japan. Methods We recruited patients (n = 204, aged 41.3 ± 13.8 (mean ± SD years old with the DSM-IV diagnosis of schizophrenia who were admitted to psychiatric hospital using a cross-sectional design. Subjects' anthropometric measurements including weight, height, body mass index (BMI, and medications were also collected. Body fat, percent (% body fat, fat- free mass, muscle mass, and body water were measured using the bioelectrical impedance analysis (BIA method. Comparative analysis was performed with schizophrenic subjects and 204 healthy control individuals. Results In a multiple regression model with age, body mass index, and dose in chlorpromazine equivalents, schizophrenia was a significantly linked with more body fat, higher % body fat, lower fat- free mass, lower muscle mass, and lower body water among males. In females, schizophrenia had a significant association with lower % body fat, higher fat- free mass, higher muscle mass, and higher body water. Conclusions Our data demonstrate gender differences with regard to changes in body composition in association with schizophrenia. These results indicate that intervention programs designed to fight obesity among schizophrenic patients should be individualized according to gender.

  12. Body composition and basal metabolic rate in Hidradenitis Suppurativa

    DEFF Research Database (Denmark)

    Miller, I M; Rytgaard, Helene Charlotte; Mogensen, U B

    2016-01-01

    BACKGROUND: Several studies have suggested an association between Hidradenitis Suppurativa (HS) and obesity. Obesity is often expressed as Body Mass Index (BMI). However, BMI lacks information on body composition. General obesity is a predictor of health status and cardiovascular risk, but body.......70-105.56) (P Hidradenitis Suppurativa is associated with a high fat percentage, high visceral fat, and low muscle percentage adding to the morbidity of HS. The higher predicted estimate of basal metabolic rate (BMR) in HS patients may reflect...

  13. Physiological models of body composition and human obesity

    OpenAIRE

    Shapses Sue A; Pierson Richard N; Heymsfield Steven B; Levitt David G; Kral John G

    2007-01-01

    Abstract Background The body mass index (BMI) is the standard parameter for predicting body fat fraction and for classifying degrees of obesity. Currently available regression equations between BMI and fat are based on 2 or 3 parameter empirical fits and have not been validated for highly obese subjects. We attempt to develop regression relations that are based on realistic models of body composition changes in obesity. These models, if valid, can then be extrapolated to the high fat fraction...

  14. Injury frequency and body composition of elite Romanian rugby players

    Directory of Open Access Journals (Sweden)

    Bogdan ALMĂJAN-GUȚĂ

    2017-03-01

    Full Text Available Background: The physical exertion in the game of rugby is intense and depends on the playing position. This study hypothesized that peculiarities of body composition are important and should be properly interpreted in order to improve fitness and particularly in order to reduce the risk of injuries. Purpose: The aim of the present paper is to highlight the importance of body composition evaluation and to underline the usefulness of the data thus obtained for both training individualization and sports injuries risk reduction. Material and Methods: Thirty seven senior male rugby players from the former Romanian national team were assessed on body composition using a segmental multi-frequency bio-impedance analyzer InBody 720 (The Body Composition Analyzer – South Korea. We compared the results from both the preseason and the regular season 2012 with the international norms for elite players and we categorized the data by playing positions. Results: We have analyzed the amount of lean mass on each limb (kg, body water content (l, percentage of body fat, bone mineral and protein content (kg. We observed that the number of injuries is directly correlated to high levels of body fat percentage, low lean mass, and edema scores. Conclusions: The risk of injury can be identified among elite rugby players not only by using fitness tests, but also by using a simple and objective test of body composition. These results show how important it is to monitor the level of body fat, lean muscle mass and muscular development in order to modify nutrition and food habits, individualize trainings and thus reduce the number of injuries.

  15. Influence of orlistat on bone turnover and body composition

    DEFF Research Database (Denmark)

    Gotfredsen, A; Westergren Hendel, H; Andersen, T

    2001-01-01

    of bone mineral and body composition included total bone mineral content (TBMC), total bone mineral density (TBMD), lumbar spine BMC and BMD, forearm BMC and BMD, fat mass (FM), fat free-mass (FFM), percentage fat mass (FM%) as well as a DXA estimate of the body weight. Body composition (FM, FFM and FM...... biochemical variables except s-osteocalcin changed significantly after 1 y in the OLS group, disclosing a pattern of an incipient negative vitamin D balance, a secondary increase in PTH-secretion, and an increase in bone turnover with the emphasis on an increase in resorption parameters (fU-OHpr/creat, f...

  16. Body Composition Changes after Weight-Loss Interventions among Obese Females: A Comparison of Three Protocols

    Directory of Open Access Journals (Sweden)

    Nayera E. Hassan

    2014-12-01

    Full Text Available AIM: To evaluate body composition changes after use of three different types of obesity management protocols: dietary measures and physical activity; acupuncture or laser acupuncture with healthy diet; aiming at achieving stable weight loss among obese Egyptian females. METHODS:  A randomized longitudinal prospective study included 76 obese adult females; aged 26 up to 55 years. Anthropometric, body composition, ultrasonographic and biochemical assessments were done. RESULTS: The three types of obesity management protocols showed significant improvement in body composition (decrease in fat% and increases in FFM and TBW and visceral fat by US. However, nutritional intervention showed highly significant improvement in the skin fold thickness at triceps and biceps sites and peripheral adiposity index.  Acupuncture intervention showed highly significant improvement in fasting blood glucose (decreased and lipid profile (decreased triglycerides, total cholesterol and LDL, and increased HDL. Laser intervention showed highly significant improvement in all the skin fold thickness and some parameters of lipid profile (decreased total cholesterol and LDL. CONCLUSIONS: The three obesity management protocols have significant effect on body composition, but acupuncture has the best effect in improving the lipid profile and fasting blood sugar. In addition, Laser intervention was recommended to improve skin fold thickness and subcutaneous fat.

  17. A novel amperometric biosensor based on gold nanoparticles-mesoporous silica composite for biosensing glucose

    Institute of Scientific and Technical Information of China (English)

    ZHANG JingJing; ZHU JunJie

    2009-01-01

    We report a novel bienzyme bioseneor based on the assembly of the glucose oxidase (GOD) and horseradish peroxidase (HRP) onto the gold nanoparticles encapsulated mesoporous silica SBA-15 composite (AuNPs-SBA-15). Electrochemical behavior of the bienzyme bioconjugatse biosensor is studied by cyclic voltammetry and electrochemical impedance spectroscopy. The results indicate that the presence of mesoporous AuNPs-SBA-15 greatly enhanced the protein Ioadings, accelerated inter-facial electron transfer of HRP and the electroconducting surface, resulting in the realization of direct electrochemistry of HRP. Owing to the electrocatalytic effect of AuNPs-SBA-15 composite, the biosen-sor exhibits a sensitive response to H2O2 generated from enzymatic reactions. Thus the bienzyme biosensor could be used for the detection of glucose without the addition of any mediator. The detec-tion limit of glucose was 0.5 μM with a linear range from 1 to 48 μM.

  18. A novel amperometric biosensor based on gold nanoparticles-mesoporous silica composite for biosensing glucose

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    We report a novel bienzyme biosensor based on the assembly of the glucose oxidase (GOD) and horseradish peroxidase (HRP) onto the gold nanoparticles encapsulated mesoporous silica SBA-15 composite (AuNPs-SBA-15). Electrochemical behavior of the bienzyme bioconjugates biosensor is studied by cyclic voltammetry and electrochemical impedance spectroscopy. The results indicate that the presence of mesoporous AuNPs-SBA-15 greatly enhanced the protein loadings, accelerated interfacial electron transfer of HRP and the electroconducting surface, resulting in the realization of direct electrochemistry of HRP. Owing to the electrocatalytic effect of AuNPs-SBA-15 composite, the biosensor exhibits a sensitive response to H2O2 generated from enzymatic reactions. Thus the bienzyme biosensor could be used for the detection of glucose without the addition of any mediator. The detection limit of glucose was 0.5 μM with a linear range from 1 to 48 μM.

  19. Effects of stress on exacerbation of diabetes mellitus, serum glucose and cortisol levels and body weight in rats.

    Science.gov (United States)

    Radahmadi, Maryam; Shadan, Farrokh; Karimian, Seied Morteza; Sadr, Seied Shahab-e-din; Nasimi, Ali

    2006-02-21

    The effects of stress on the serum glucose, serum cortisol levels and body weight were investigated to clarify the possible link between the stress and diabetes. The experiments were performed on nondiabetic and streptozotocin diabetic rats divided to control, sham and stressed groups. Water immersion was used as stressor. After the experiment, blood samples were collected. The serum glucose level (SGL) was measured by the glucose oxidase method and serum cortisol level (SCL) was determined by radioimmunoassay. Stress caused a significant increase in glucose level in both nondiabetic and diabetic rats. In diabetes rats, a significant increase in SCL was observed. Stress did not cause, however, significant increases in SCL. A significant weight loss took place in rats exposed to stress and that was much greater in diabetic animals. The stress with mainly psychic component exacerbated the diabetes in streptozotocin treated rats and the glucose levels increased significantly also in nondiabetic controls, but no glucose was detected in their urine.

  20. Dialysis vintage, body composition, and survival in peritoneal dialysis patients.

    Science.gov (United States)

    Avram, Morrell M; Mittman, Neal; Fein, Paul A; Agahiu, Samuel; Hartman, William; Chattopadhyay, Neil; Matza, Betty

    2012-01-01

    The relationship between dialysis vintage (length of time on dialysis), body composition, and survival has been reported in hemodialysis patients. In the present study, we examined the association ofdialysis vintage with body composition and survival in peritoneal dialysis (PD) patients. At enrollment, body composition in 65 PD patients was determined by bioelectrical impedance analysis. Patients (mean age at enrollment: 54 years) were followed for up to 11 years maximum. At enrollment, the mean, median, and maximum dialysis vintages were 51, 34, and 261 months respectively. After adjusting for age, race, sex, and diabetes status, dialysis vintage was indirectly correlated (partial correlation coefficients) with body weight (r = -0.40, p = 0.001), body mass index (r = -0.40, p = 0.002), body surface area (r = -0.39, p = 0.002), body cell mass (r = -0.39, p = 0.002), total body fat weight (r = -0.30, p = 0.02), and fat percentage of body weight (r = -0.31, p = 0.018), and directly correlated with extracellular mass to body cell mass ratio (r = 0.27, p = 0.039). The observed cumulative survival was significantly higher (p = 0.007) in patients with a dialysis vintage at enrollment of 35 months or less, than in patients with dialysis vintage at enrollment of more than 35 months. In the multivariate Cox regression analysis, adjusting for age, race, sex, and diabetes, dialysis vintage at enrollment remained an independent predictor of mortality (relative risk: 1.010; p = 0.002). Increase in relative risk of death with increasing dialysis vintage may be partly explained by the association of vintage with unfavorable changes in body composition and the nutrition status of patients over time.

  1. Relationships Between Body Image, Body Composition, Sexual Functioning, and Sexual Satisfaction Among Heterosexual Young Adults.

    Science.gov (United States)

    Milhausen, Robin R; Buchholz, Andrea C; Opperman, Emily A; Benson, Lindsay E

    2015-08-01

    This study investigated the association between body image and body-image self-consciousness on sexual satisfaction, accounting for relationships between body fat and body image, and between sexual functioning and sexual satisfaction, while controlling for relationship satisfaction. Participants were 143, 18-25 year-old Caucasian men and women in heterosexual monogamous relationships, recruited from the University of Guelph and surrounding community in Ontario, Canada. Various domains of body image, body-image self-consciousness, sexual satisfaction and functioning, and relationship satisfaction data were collected by questionnaires. Body fat was measured using dual energy X-ray absorptiometry. Among men, body image was positively associated with sexual satisfaction, after controlling for relationship satisfaction. Men with greater body fat were more likely to have poorer behavioral and affective body image. Only body image specific to the sexual encounter influenced sexual functioning. Among women, no domain of body image was associated with sexual satisfaction, after controlling for relationship satisfaction. Women with greater body fat were more likely to have poorer affective and sexual-encounter-specific body image. As percent total fat increased, sexual functioning decreased. Our results suggest a complex pattern of relationships exists among body image and body composition constructs and sexual and relationship variable; and that these relationships are not the same for men and women.

  2. Body composition as measured by in vivo neutron activation analysis

    Energy Technology Data Exchange (ETDEWEB)

    Cohn, S.H.; Sawitsky, A.; Vartsky, D.; Yasumura, S.; Zanzi, I.; Gartenhaus, W.; Ellis, K.J.

    1979-01-01

    A large scale study is currently underway on the changes in body composition resulting from the cachexia of malignancy. The ultimate objective of the overall project is to assess the changes in body composition associated with hyperalimentation and other modes of nutritional support to cancer patients. The first phase of this study is now in progress. In this phase, a study is being made of a control group of normal patients to provide baseline data against which data from cancer patients can be evaluated. Total body nitrogen and potassium are measured in a group of normal men and women, and are analyzed as a function of age. Additionally, changes in skeletal mass (total body calcium) are also recorded, and body water is measured simultaneously with the use of tritiated water.

  3. Change of body composition in process of power conditional training

    Directory of Open Access Journals (Sweden)

    Anikieiev D.M.

    2015-12-01

    Full Text Available Purpose: to work out recommendations on choosing of exercises for power conditional trainees, considering decrease of fat mass percentage as the purpose. Methods: analysis of changes of body composition of trainees, practicing different kinds of conditional power training. Results: the data about influence of different physical loads on thickness of subcutaneous fat in different parts of body have been generalized. Recommendations on choosing of exercises for power conditional trainees for body composition improving have been presented. It was found that fat loss occurs quicker in upper part of body (subcutaneous and visceral. This is observed with increasing of motor functioning and reducing calories of eating. When training any separate muscular group changes of subcutaneous fat take place not compulsory in body parts, in which the trained group is located. Conclusions: it is purposeful to mainly use basic (multi-joint exercises in power conditional training.

  4. The characteristics of pre-diabetic patients associated with body composition and cardiovascular disease risk factors in the Iranian population

    Directory of Open Access Journals (Sweden)

    Zahra Gholi

    2016-01-01

    Full Text Available Background: Different populations have shown various patterns of association between impaired fasting glucose (IFG and body composition parameters and risk factors of cardiovascular disease (CVD. The current study aimed at investigating the differences between persons with prediabetes and healthy people in terms of CVD risk factors including body composition parameters, blood pressure, and lipid profile in a sample of the Iranian population. Materials and Methods: In a case-control setting, a sample containing 386 (193 prediabetic subjects and 193 normal subjects of the first-degree relatives of diabetic patients aged 35-55 years were investigated. Samples were assessed using glucose tolerance categories. Prediabetes was defined according to the American Diabetes Association (ADA criteria. Body composition parameters, blood pressure, glucose parameters, and lipid profile were measured and compared between the two groups. Results: Prediabetic patients had higher body mass index (BMI, waist circumference (WC, and body fat (BF in comparison to the control group (P < 0.05. In addition, prediabetic subject had a higher intake of energy, carbohydrate, protein, fat, and cholesterol and it seems that these patients had an unhealthy dietary intake (P < 0.05. Fasting blood glucose (FBG (P < 0.001, total cholesterol (P = 0.007, low-density lipoprotein cholesterol (LDL-C, and triglyceride (P = 0.021 were higher in prediabetic patients (P < 0.05 than in the controls. Conclusion: Both the risk factors of CVD and body composition parameters were different between the prediabetic and normal groups; total cholesterol (TC, triglyceride (TG, and FBS were predictors of the risk of prediabetes.

  5. The characteristics of pre-diabetic patients associated with body composition and cardiovascular disease risk factors in the Iranian population

    Science.gov (United States)

    Gholi, Zahra; Heidari-Beni, Motahar; Feizi, Awat; Iraj, Bijan; Askari, Gholamreza

    2016-01-01

    Background: Different populations have shown various patterns of association between impaired fasting glucose (IFG) and body composition parameters and risk factors of cardiovascular disease (CVD). The current study aimed at investigating the differences between persons with prediabetes and healthy people in terms of CVD risk factors including body composition parameters, blood pressure, and lipid profile in a sample of the Iranian population. Materials and Methods: In a case-control setting, a sample containing 386 (193 prediabetic subjects and 193 normal subjects) of the first-degree relatives of diabetic patients aged 35-55 years were investigated. Samples were assessed using glucose tolerance categories. Prediabetes was defined according to the American Diabetes Association (ADA) criteria. Body composition parameters, blood pressure, glucose parameters, and lipid profile were measured and compared between the two groups. Results: Prediabetic patients had higher body mass index (BMI), waist circumference (WC), and body fat (BF) in comparison to the control group (P < 0.05). In addition, prediabetic subject had a higher intake of energy, carbohydrate, protein, fat, and cholesterol and it seems that these patients had an unhealthy dietary intake (P < 0.05). Fasting blood glucose (FBG) (P < 0.001), total cholesterol (P = 0.007), low-density lipoprotein cholesterol (LDL-C), and triglyceride (P = 0.021) were higher in prediabetic patients (P < 0.05) than in the controls. Conclusion: Both the risk factors of CVD and body composition parameters were different between the prediabetic and normal groups; total cholesterol (TC), triglyceride (TG), and FBS were predictors of the risk of prediabetes. PMID:27904566

  6. Hedgehog signalling in myeloid cells impacts on body weight, adipose tissue inflammation and glucose metabolism.

    Science.gov (United States)

    Braune, Julia; Weyer, Ulrike; Matz-Soja, Madlen; Hobusch, Constance; Kern, Matthias; Kunath, Anne; Klöting, Nora; Kralisch, Susann; Blüher, Matthias; Gebhardt, Rolf; Zavros, Yana; Bechmann, Ingo; Gericke, Martin

    2017-05-01

    Recently, hedgehog (Hh) was identified as a crucial player in adipose tissue development and energy expenditure. Therefore, we tested whether Hh ligands are regulated in obesity. Further, we aimed at identifying potential target cells of Hh signalling and studied the functional impact of Hh signalling on adipose tissue inflammation and glucose metabolism. Hh ligands and receptors were analysed in adipose tissue or serum from lean and obese mice as well as in humans. To study the impact on adipose tissue inflammation and glucose metabolism, Hh signalling was specifically blocked in myeloid cells using a conditional knockout approach (Lys-Smo (-/-)). Desert Hh (DHH) and Indian Hh (IHH) are local Hh ligands, whereas Sonic Hh is not expressed in adipose tissue from mice or humans. In mice, obesity leads to a preferential upregulation of Hh ligands (Dhh) and signalling components (Ptch1, Smo and Gli1) in subcutaneous adipose tissue. Further, adipose tissue macrophages are Hh target cells owing to the expression of Hh receptors, such as Patched1 and 2. Conditional knockout of Smo (which encodes Smoothened, a mandatory Hh signalling component) in myeloid cells increases body weight and adipose tissue inflammation and attenuates glucose tolerance, suggesting an anti-inflammatory effect of Hh signalling. In humans, adipose tissue expression of DHH and serum IHH decrease with obesity and type 2 diabetes, which might be explained by the intake of metformin. Interestingly, metformin reduced Dhh and Ihh expression in mouse adipose tissue explants. Hh signalling in myeloid cells affects adipose tissue inflammation and glucose metabolism and may be a potential target to treat type 2 diabetes.

  7. Impact of Current and Emerging Glucose-Lowering Drugs on Body Weight in Type 2 Diabetes.

    Science.gov (United States)

    Lau, David C W; Teoh, Hwee

    2015-12-01

    Type 2 diabetes is a progressive disease, and most people with diabetes will eventually require adjunctive pharmacotherapy to optimize their glycemic control. As the majority of people with type 2 diabetes are overweight or obese, weight management is an essential component of diabetes management to improve their overall health and quality of life. Many of the currently available glucose-lowering drugs are associated with weight gain, which makes it challenging for both prescribing clinicians and patients. The 2015 Canadian Diabetes Association Clinical Practice Guidelines interim update on the pharmacologic management of type 2 diabetes recommend individualization of therapy and glycemic targets. Clinicians should take into consideration not only the drug's efficacy and safety profiles but also its propensity for causing hypoglycemia and weight gain. Given that the number of glucose-lowering drugs is expanding rapidly, a better understanding of the impacts of current and emerging therapies on body weight will serve as a useful guide. Metformin remains the first-line drug after diet and exercise therapy. The next add-on agent could be selected from the incretin or sodium-glucose cotransporter-2 inhibitor class because these drugs rarely cause hypoglycemia and may lead to modest weight loss. When insulin therapy is considered, choosing a basal insulin that is associated with less nocturnal hypoglycemia and weight gain is recommended. Emerging therapies using combination therapy of an incretin-sodium-glucose cotransporter 2 inhibitor or glucagon-like peptide-1 agonist-basal insulin hold promise to achieve robust glycemic control with weight loss and low risk for hypoglycemia.

  8. Body composition differences in normal weight, obese-overweight and anorexic adolescents: role of adipocytokines.

    Science.gov (United States)

    Ondrak, Kristin S; Hackney, Anthony C

    2010-01-01

    Adipocytokines are signaling molecules released by adipose tissue with numerous functions, including regulation of metabolism, inflammatory process, and body mass. They are particularly interesting in youth, considering the rising prevalence of overweight/obesity and the linkage of this condition to inflammation. This chapter examines the relationship between body composition and select adipocytokines: leptin, adiponectin, IL-6, TNF-α, and resistin, in overweight, normal weight and anorexic youth. Leptin, which stimulates energy expenditure and promotes satiety, is highest in overweight youth, followed by normal weight and lastly anorexic youth. Adiponectin has similar functions to leptin but is negatively correlated with measures of body composition. Anorexic youth have the highest adiponectin per kg fat mass, followed by normal weight and overweight. Conversely, IL-6 is positively associated with body composition; however, research in anorexic youth is inconclusive. It has some pro-inflammatory effects and promotes glucose and fat use, therefore beneficial for maintenance of normal weight status. TNF-α is also a pro-inflammatory adipocytokine thought to be somewhat protective against cancer. TNF-α is highest in overweight, followed by normal weight and anorexic youth, similar to leptin. Finally, resistin is also involved in the pro-inflammatory response and the development of insulin resistance. However, far less research exists on this adipocytokine and its relation to body composition in overweight or anorexic youth is equivocal. In conclusion, several consistent relationships exist regarding adipocytokines and body composition; however, there is a need for additional research on these relationships in youth especially at extremes of adiposity such as overweight and anorexics. Copyright © 2010 S. Karger AG, Basel.

  9. EFFECT OF REGULAR GARLIC INGESTION ON BODY WEIGHT AND BLOOD GLUCOSE: A CASE STUDY IN MICE

    Directory of Open Access Journals (Sweden)

    F.T. Djankpa, A. Osonuga*, J. Ekpale, C.E. Quaye, P. Otoo, O.A. Osonuga and S.K. Amoah

    2012-05-01

    Full Text Available Garlic a perennial erect plant is known to have sulphur-containing compounds that act on the hypothalamus increasing the sensitivity of the hypothalamus to leptin which alters the set point at which satiety is reached causing an organism to eat less. Nine mice (six of which were obese were used in this study and grouped into three. Groups A and B were made of 3 obese mice each whereas group C consisted of 3 non-obese mice. For group A and group C mice, 20 ml aqueous garlic extract was added to their feed daily whereas no garlic was added to the feed of group B mice. The study was carried out over a period of 44 days. The weight and blood glucose was measured weekly and the average for each group was computed. Results indicated that Group A mice recorded a reduction in mean body weight by 46.5% (p<0.05. Group B mice had significant increase in mean body weight by 46.2% (p<0.05. The blood glucose level dropped significantly by 18.5% (p<0.05 in group A mice. Garlic had weight loss and hypoglycemic effect in obese mice. These effects were absent in non-obese mice.

  10. Suppression of Endogenous Glucose Production by Isoleucine and Valine and Impact of Diet Composition

    Directory of Open Access Journals (Sweden)

    Isabel Arrieta-Cruz

    2016-02-01

    Full Text Available Leucine has been shown to acutely inhibit hepatic glucose production in rodents by a mechanism requiring its metabolism to acetyl-CoA in the mediobasal hypothalamus (MBH. In the early stages, all branched-chain amino acids (BCAA are metabolized by a shared set of enzymes to produce a ketoacid, which is later metabolized to acetyl-CoA. Consequently, isoleucine and valine may also modulate glucose metabolism. To examine this possibility we performed intrahypothalamic infusions of isoleucine or valine in rats and assessed whole body glucose kinetics under basal conditions and during euglycemic pancreatic clamps. Furthermore, because high fat diet (HFD consumption is known to interfere with central glucoregulation, we also asked whether the action of BCAAs was affected by HFD. We fed rats a lard-rich diet for a short interval and examined their response to central leucine. The results showed that both isoleucine and valine individually lowered blood glucose by decreasing liver glucose production. Furthermore, the action of the BCAA leucine was markedly attenuated by HFD feeding. We conclude that all three BCAAs centrally modulate glucose metabolism in the liver and that their action is disrupted by HFD-induced insulin resistance.

  11. Suppression of Endogenous Glucose Production by Isoleucine and Valine and Impact of Diet Composition.

    Science.gov (United States)

    Arrieta-Cruz, Isabel; Su, Ya; Gutiérrez-Juárez, Roger

    2016-02-15

    Leucine has been shown to acutely inhibit hepatic glucose production in rodents by a mechanism requiring its metabolism to acetyl-CoA in the mediobasal hypothalamus (MBH). In the early stages, all branched-chain amino acids (BCAA) are metabolized by a shared set of enzymes to produce a ketoacid, which is later metabolized to acetyl-CoA. Consequently, isoleucine and valine may also modulate glucose metabolism. To examine this possibility we performed intrahypothalamic infusions of isoleucine or valine in rats and assessed whole body glucose kinetics under basal conditions and during euglycemic pancreatic clamps. Furthermore, because high fat diet (HFD) consumption is known to interfere with central glucoregulation, we also asked whether the action of BCAAs was affected by HFD. We fed rats a lard-rich diet for a short interval and examined their response to central leucine. The results showed that both isoleucine and valine individually lowered blood glucose by decreasing liver glucose production. Furthermore, the action of the BCAA leucine was markedly attenuated by HFD feeding. We conclude that all three BCAAs centrally modulate glucose metabolism in the liver and that their action is disrupted by HFD-induced insulin resistance.

  12. Continuous Glucose Monitoring in Female NOD Mice Reveals Daily Rhythms and a Negative Correlation With Body Temperature.

    Science.gov (United States)

    Korstanje, Ron; Ryan, Jennifer L; Savage, Holly S; Lyons, Bonnie L; Kane, Kevin G; Sukoff Rizzo, Stacey J

    2017-09-01

    Previous studies with continuous glucose monitoring in mice have been limited to several days or weeks, with the mouse's physical attachment to the equipment affecting behavior and measurements. In the current study, we measured blood glucose and body temperature at 10-second intervals for 12 weeks in a cohort of NOD/ShiLtJ female mice using wireless telemetry. This allowed us to obtain a high-resolution profile of the circadian rhythm of these two parameters and the onset of hyperglycemic development in real time. The most striking observations were the elevated nocturnal concentrations of glucose into the diabetic range days before elevations in diurnal glucose (when glucose concentrations are historically measured) and the strong, negative correlation between elevated blood glucose concentrations and body temperature with a steady decline of the body temperature with diabetes development. Taken together, this technological advancement provides improved resolution in the study of the disease trajectory of diabetes in mouse models, including relevant translatability to the current technologies of continuous glucose monitoring now regularly used in patients. Copyright © 2017 Endocrine Society.

  13. Composition of Staff Review Advisory Bodies - 2003

    CERN Multimedia

    2003-01-01

    For the present staff review, the advisory bodies set up to prepare recommendations are composed as follows : Senior Staff Advancement Committee (SSAC) David Plane/EP [Convener] Enrico Chiaveri/AB Peter Schmid/EP Technical Engineers & Administrative Careers Committee (TEACC) Robin Lauckner/AB [Chairman]Marcel Mottier/EST Michael Letheren/EP Louis Walckiers/AT Lucie Linssen/EP Mats Wilhelmsson/ST Long-term contract Boards (LTCBs) LTCB 1 (Categories 2 & 5a) Tiziano Camporesi/EP [Convener]Florence Ranjard/EP [Alternate] Roger Bailey/ABPeter Sievers/AT " " Doris Forkel-Wirth/TISPierre Ninin/ST " " Rob Rayson/HRMaarten Wilbers/DSU " " Seamus Hegarty/HR [Secretary] LTCB 2 (Categories 3, 4, 5b & 5c) Véronique Paris/AB [Convener]Fabien Perriollat/AB [Alternate] Christian Lasseur/ESTRamon Folch/EST " " Lucie Linssen/EP Alfredo Placci/EP " " Mats Møller/ASLaszlo Abel/SPL " " Seamus Hegarty/HR [Secretary] Human Resources Division Tel. 74128

  14. COMPOSITION OF STAFF REVIEW ADVISORY BODIES - 2002

    CERN Multimedia

    Human Resources Division

    2002-01-01

    For the present staff review, the advisory bodies set up to prepare recommendations are composed as follows: Senior Staff Advancement Committee (SSAC) Cristoforo BENVENUTI/EST [Convener] David PLANE/EP Peter SCHMID/EP Technical Engineers & Administrative Careers Committee (TEACC) Robin LAUCKNER/SL [Chairman] Flemming PEDERSEN/PS Lucie LINSSEN/EP Dietrich SCHINZEL/EP Marcel MOTTIER/EST Louis WALCKIERS/LHC Long-term contract Boards (LTCBs) (Categories 2 & 5a) Tiziano CAMPORESI/EP [Convener] Florence RANJARD/EP [Alternate] Jacques GRUBER/PS [until 30.6.2002] Roger BAILEY/SL [from 1.7. 2002] Peter SIEVERS/LHC [Alternate] Doris FORKEL-WIRTH/TIS Pierre NININ/ST [Alternate] Sue FOFFANO/AS Maarten WILBERS/DSU [Alternate] Werner ZAPF/HR[Secretary] LTCB 2 Categories 3, 4, 5b & 5c) Véronique PARIS/SL [Convener] Fabien PERRIOLLAT/PS [Alternate] Mats WILHELMSSON/ST Charles NUTTALL/TIS [Alternate] Lucie LINSSEN/EP Alfredo PLACCI/EP [Alternate] Patrick GEERAER...

  15. COMPOSITION OF STAFF REVIEW ADVISORY BODIES - 2001

    CERN Multimedia

    Seamus Hegarty / HR; Tel. 74128

    2001-01-01

    For the present staff review, the advisory bodies set up to prepare recommendations are composed as follows : Senior Staff Advancement Committee (SSAC) David O. Williams/it (Convener) Cristoforo Benvenuti/est David Plane/ep Technical Engineers & Administrative Careers Committee (TEACC) Sverre Jarp/it (Chairman) Flemming Pedersen/ps Robin Lauckner/sl Christian Roche/ett Lars Leistam/est Dietrich Schinzel/ep Long-term contract Boards (LTCBs) LTCB 1 (Categories 2 & 5a) Tiziano Camporesi/ep [Convener] - Florence Ranjard/ep [Alternate] Jacques Gruber/ps - Peter Sievers/lhc [Alternate] Thomas Pettersson/est - Michel Mayoud/est [Alternate] Sue Foffano/as - Thierry Lagrange/spl [Alternate] Werner Zapf/hr (Secretary) LTCB 2 (Categories 3, 4, 5b & 5c) Véronique Paris/sl [Convener] - Fabien Perriollat/ps [Alternate] Mats Wilhelmsson/st - Véronique Fassnacht/tis [Alternate] Lucie Linssen/ep - Alfredo Placci/ep [Alternate] Patrick Geeraert/fi - John Cuthb...

  16. Somatic maturation and body composition in female healthy adolescents with or without adjustment for body fat

    Directory of Open Access Journals (Sweden)

    Valter Paulo N. Miranda

    2014-03-01

    Full Text Available Objective: To evaluate the relationship between the stages of somatic maturation and body composition in eutrophic female adolescents with or without excessive body fat. Methods: Cross-sectional study of 118 female adolescents, from 14 to 19 years-old, in Viçosa, Minas Gerais, Southeast Brazil. The adolescents were divided in two groups: Group 1 (G1, eutrophic with adequate body fat percentage, and Group 2 (G2, eutrophic with high body fat percentage. The somatic maturation was assessed by the formula for estimating the Peak Height Velocity (PHV. Results: The PHV had higher average score in G1 adolescents compared to G2 (0.26 versus 0.05; p=0.032. There was an association between G1, G2 and the somatic maturation (p=0.049. The female adolescents before and during PHV presented higher values of fat body BMI (p=0.034 and percentage of central fat (p=0.039 compared to the adolescents after PHV. There was a correspondence between before PHV stage and the excess of body fat (α=0.751. Conclusions: There was an association between somatic maturation and body composition in eutrophic female adolescents. Length, BMI and fat percentage were different among the somatic maturation stages. It is relevant to evaluate the somatic maturation and the changes occurring in the body composition during adolescence in order to better evaluate and manage the nutritional status and the body fat excess.

  17. Glucose Biosensor Based on Carbon/PVC-COOH/Ferrocene Composite with Covalently Immobilized Enzyme

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    A carbon/PVC-COOH/ferrocene composite electrode used for the determination of glucose has been prepared. The ferrocene acted as mediator was incorporated into the PVC-COOH polymer and the leakage could be prevented. The presence of carboxyl groups on the electrode surface allowed immobilizing enzyme via EDC and NHS. The ratio of PVC-COOH to graphite powder (w/w) has been studied. Amperometric determination of glucose has been performed at potential of 0.30 V vs SCE. The response time was < 15 s. The linear response range was of 0.1-20 mmol/L with a detection limit of 48 μmol/L.

  18. Relationships between body weight, fasting blood glucose concentration, sex and age in tree shrews (Tupaia belangeri chinensis).

    Science.gov (United States)

    Wu, X; Chang, Q; Zhang, Y; Zou, X; Chen, L; Zhang, L; Lv, L; Liang, B

    2013-12-01

    The tree shrew (Tupaia belangeri chinensis) is a squirrel-like lower primate or a close relative of primates, commonly used as an animal model in biomedical research. Despite more than three decades of usage in research, the clear relationships between body weight, fasting blood glucose concentration, sex and age among tree shrews remain unclear. Based on an investigation of 992 tree shrews (454 males and 538 females) aged between 4 months and 4 years old, we found that male tree shrews have significantly higher body weight and fasting blood glucose concentration than female tree shrews (p < 0.001). The concentration of fasting blood glucose slightly increased with body weight in males (r = 0.152, p < 0.001). Meanwhile, in females, the body weight, concentration of fasting blood glucose and waist circumference positively increased with age (p < 0.001). Additionally, 17 tree shrews with Lee index [body weight (g)*0.33*1000/body length (cm)] above 290 had significantly higher body weight, waist circumference and glycated haemoglobin A1c (HbA1c) than non-obese tree shrews with a Lee index score below 290 (p < 0.001). Interestingly, 6 of 992 tree shrews (three males and three females, 2-4 years old) displayed impaired plasma triglycerides, HbA1c, low-density lipoprotein and oral glucose tolerance test, suggestive of the early symptoms of metabolic syndrome. This study provides the first clear relationships between body weight, fasting blood glucose concentration, sex and age in tree shrews, further improving our understanding of this relationship in metabolic syndrome (MetS). Given the similarity of tree shrews to humans and non-human primates, this finding supports their potential use as an animal model in the research of MetS.

  19. Quality control issues related to assessment of body composition.

    Science.gov (United States)

    Wootton, Stephen; Durkin, Kesta; Jackson, Alan

    2014-06-01

    There are no internationally agreed quality standards for the measurement of stature, weight, and body composition. This lack of agreement constrains the quality of work in nutrition and must be addressed in order to build systemic capacity within the Scaling Up Nutrition agenda. There is a need to reach agreement and define standards of performance and the required training to be able to demonstrate the competency of those responsible for making the measurements. This, together with the adoption of standardized protocols, traceable reference materials, quality assurance frameworks, and publication guidance, would mark an important first step in improving the conduct and interpretation of measurements of growth and body composition.

  20. Body Composition and Somatotype of the Elite of Polish Fencers

    OpenAIRE

    Sterkowicz-Przybycień, Katarzyna

    2009-01-01

    The purpose of this study was to determine body composition and somatotype of the male fencers who were grouped by different fencing weapons. Analysis of body composition, with untrained men as background, will update the data necessary for the somatic profiles of fencers. Thirty contestants were examined during the Polish Fencing Championships in 2004. They took part in épée (n=10), foil (n=10) and sabre (n=10). They were aged 23.3±2.9; their length of training was 12.6±2.5 years, with the f...

  1. Determination of body composition from skinfold thickness: a validation study.

    Science.gov (United States)

    Reilly, J J; Wilson, J; Durnin, J V

    1995-01-01

    Measurement of body composition is proving increasingly important in clinical nutrition and research. Skinfold thickness is a simple means of estimating body composition which is widely used in children, but there is little information on its validity. There has been a proliferation of equations for estimation of body composition from skinfolds, but some doubt as to their general applicability. The aim of the present study was to validate five currently used equations for this purpose in a sample of 98 healthy prepubertal children (64 boys, 34 girls), mean (SD) age 9.1 (1.7) years by comparison of estimates from each equation with measurements of fatness derived from hydrodensitometry. Differences between methods were determined by calculation of biases and limits of agreement. Limits of agreement between predicted and measured fatness were wide, particularly in the girls, and some distinct biases were apparent. Choice of prediction equation therefore has a substantial influence on the estimate of fatness obtained when using skinfolds in children. The existing published equations are associated with large random errors or significant systematic errors. For the time being skinfolds might best be regarded as indices (rather than measures) of body fatness in individuals, or means of estimating body fatness of groups. Estimating the total body fatness of individual prepubertal children using skinfolds, on the basis of this evidence, is not advisable at present. PMID:7492193

  2. Magnetite nanoparticles-chitosan composite containing carbon paste electrode for glucose biosensor application.

    Science.gov (United States)

    Kavitha, A L; Prabu, H Gurumallesh; Babu, S Ananda; Suja, S K

    2013-01-01

    This work was aimed to develop reusable magnetite chitosan composite containing carbon paste electrode for biosensor application. Glucose oxidase (GOx) enzyme was used to prepare GOx-magnetite-chitosan nanocomposite containing carbon paste electrode for sensitive detection of glucose. The immobilized enzyme retained its bioactivity, exhibited a surface confined reversible electron transfer reaction, and had good stability. The surface parameters like surface coverage (tau), Diffusion coefficient (D0), and rate constant (kS) were studied. The carbon paste modified electrode virtually eliminated the interference during the detection of glucose. The excellent performance of the biosensor is attributed to large surface-to-volume ratio, high conductivity and good biocompatibility of chitosan, which enhances the enzyme absorption and promotes electron transfer between redox enzymes and the surface of electrode. The shelf life of the developed electrode system is about 12 weeks under refrigerated conditions. We report for the first time in the fabrication of carbon paste bioelectrode containing magnetite-chitosan-GOx.

  3. Effects of photoperiod on body mass, thermogenesis and body composition in Eothenomys miletus during cold exposure

    Directory of Open Access Journals (Sweden)

    Wan-long Zhu

    2012-05-01

    Full Text Available Many small mammals respond to seasonal changes in photoperiod by altering body mass and adiposity. These animals may provide valuable models for understanding the regulation of energy balance. In present study, we examined the effect on body mass, rest metabolic rate, food intake and body composition in cold-acclimated (5 °C in Eothenomys miletus by transferring them from a short (SD, 8h :16h L: D to long day photoperiod (LD, 16h: 8h L:D. During the first 4 weeks of exposure to SD, E. miletus decreased body mass. After the next 4 weeks of exposure to LD, which the average difference between body masses of LD and SD voles was 4.76 g. This 14.74% increase in body mass reflected significant increases in absolute amounts of body components, including wet carcass mass, dry carcass mass and body fat mass. After correcting body composition and organ morphology data for the differences in body mass, only livers, kidney, and small intestine were enlarged due to photoperiod treatment during cold exposure. E. miletus increased RMR and energy intake exposure to LD, but maintained a stable level to SD after 28 days. Serum leptin levels were positively correlated with body mass, body fat mass, RMR as well as energy intake. All of the results indicated that E. miletus may provide an attractive novel animal model for investigation of the regulation of body mass and energy balance at organism levels. Leptin is potentially involved in the photoperiod induced body mass regulation and thermogenesis in E. miletus during cold exposure.

  4. Lack of agreement between the revised criteria of impaired fasting glucose and impaired glucose tolerance in children with excess body weight.

    Science.gov (United States)

    Gómez-Díaz, Rita; Aguilar-Salinas, Carlos A; Morán-Villota, Segundo; Barradas-González, Rosalinda; Herrera-Márquez, Rocio; Cruz López, Miguel; Kumate, Jesus; Wacher, Niels H

    2004-09-01

    The aim of this study was to describe the agreement between impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) in children with excess body weight using the original and the revised definitions of IFG. Obese and overweight children aged 4-17 years were included (n = 533). Anthropometric parameters and biochemical tests (fasting and 2-h glucose tests after an oral glucose load [1.75 g/kg]) were performed. Case subjects with a fasting plasma glucose >/=126 mg/dl were excluded. The diagnostic parameters of the original and the revised definitions of IFG for detecting IGT were estimated. The analysis of agreement between these categories was made using the kappa test. The prevalence of IFG increased from 6.2 to 13.3% using the new criteria. The prevalence of IFG became closer to the prevalence of IGT (14.8%). The revised criteria increased the sensitivity from 26.6 to 36.7%. However, the new IFG definition was not useful for identifying IGT cases. Of the 71 case subjects with IFG, only 29 (40.8%) had IGT. In addition, 50 case subjects with IGT (9.4%) and 13 with diabetes (2.4%) had a fasting glycemia <100 mg/dl. A poor agreement was found between the 2003 IFG definition and abnormal 2-h postchallenge plasma glucose (kappa = 0.359). The proportion of false-positive cases increased (36.3-59.1%) under the new definition. The new definition modestly increases the sensitivity of IFG for detecting IGT in children with excess body weight. Despite this, more than one-half of these cases are not detected. In addition, the false-positive rate was increased by 61%.

  5. Effects of canagliflozin on body weight and body composition in patients with type 2 diabetes over 104 weeks.

    Science.gov (United States)

    Blonde, Lawrence; Stenlöf, Kaj; Fung, Albert; Xie, John; Canovatchel, William; Meininger, Gary

    2016-05-01

    Canagliflozin, a sodium glucose co-transporter 2 (SGLT2) inhibitor, has been associated with weight loss in a broad range of patients with type 2 diabetes mellitus (T2DM). This analysis further evaluated changes in body weight and composition with canagliflozin in two 104-week, Phase 3 studies. In Study 1, patients aged 18-80 years (N = 1,450) received canagliflozin 100 or 300 mg or glimepiride as add-on to metformin for a 52-week core treatment period, followed by a 52-week extension period. In Study 2, patients aged 55-80 years (N = 714) received canagliflozin 100 or 300 mg or placebo added to stable background antihyperglycemic agents for a 26-week core treatment period, followed by a 78-week extension period. Percent change from baseline in body weight; proportion of patients with any weight loss, ≥5% weight loss, and ≥10% weight loss; change in body mass index (BMI) and waist circumference; change in body weight across weight-loss quartiles; and changes in body composition were evaluated in both studies. Canagliflozin 100 and 300 mg provided sustained weight loss versus either glimepiride or placebo over 104 weeks. More patients experienced any weight loss and ≥5% weight loss with canagliflozin versus comparator. Across the 3 highest weight-loss quartiles, canagliflozin provided greater weight loss versus glimepiride or placebo. BMI and waist circumference reductions were observed with canagliflozin 100 and 300 mg versus either glimepiride or placebo over 104 weeks; more patients had BMI or waist circumference reductions with canagliflozin versus comparator. Body composition analysis indicated that the majority of weight loss was due to loss of fat mass. Canagliflozin was generally well tolerated, with increased incidence of adverse events related to the SGLT2 inhibition mechanism. Canagliflozin 100 and 300 mg provided sustained reductions in body weight, BMI, and waist circumference in a greater proportion of patients with T2DM versus

  6. Local forearm and whole-body respiratory quotient in humans after an oral glucose load: methodological problems

    DEFF Research Database (Denmark)

    Simonsen, L; Bülow, J; Madsen, Jan Lysgård;

    1993-01-01

    The effects of an oral glucose load of 75 g on the local forearm and whole-body energy thermogenesis were measured in normal subjects during the 4 h after the glucose intake. Simultaneous assessment of substrate metabolism in the forearm was performed. Energy expenditure (EE) increased after...... and local forearm RQ are not significantly different in the fasting state. The finding of a decrease in local forearm RQ below 0.70 30 min after the glucose load probably indicates a non-steady state in the carbon dioxide exchange. Thus, indirect calorimetry cannot be applied locally during short time...

  7. Effects of bariatric surgery on the body composition of adults

    Directory of Open Access Journals (Sweden)

    Tiago Wally Hartwig

    2013-09-01

    Full Text Available The most alarming cases are known as morbidly obese. An effective method to change the anthropometric characteristics of this population with excess body weight and high fat mass is bariatric surgery. The objective of this study was to analyze the body composition of morbidly obese patients undergoing bariatric surgery in the city of Pelotas, Southern Brazil. In a prospective cohort study, a group of morbidly obese patients was followed up 30 days before and 30 days after surgery. The sample consisted of 123 patients who underwent vertical banded Roux-en-Y gastroplasty between April 2003 and May 2010. Body composition (fat percentage was determined by bioelectrical impedance analysis. The mean age of the patients was 36.1 ± 8.8 years and mean body weight loss was 14.1 ± 6.0 kg (p<0.001. The mean reduction in body mass index (BMI was 5.2 ± 2.1 kg/m2 (p<0.001. Body fat percentage and fat mass were reduced by 2.8% (p<0.001 and 9.7 ± 4.9 kg (p<0.001, respectively. In addition, there was a reduction of 4.4 ± 3.4 kg (p<0.001 in lean mass. We concluded that the surgical procedure significantly reduced body weight, BMI, fat percentage and fat mass and is an alternative when conventional treatments appear ineffective.

  8. Caenorhabditis elegans PAQR-2 and IGLR-2 Protect against Glucose Toxicity by Modulating Membrane Lipid Composition

    Science.gov (United States)

    Svensk, Emma; Devkota, Ranjan; Ståhlman, Marcus; Ranji, Parmida; Rauthan, Manish; Magnusson, Fredrik; Hammarsten, Sofia; Johansson, Maja; Borén, Jan; Pilon, Marc

    2016-01-01

    In spite of the worldwide impact of diabetes on human health, the mechanisms behind glucose toxicity remain elusive. Here we show that C. elegans mutants lacking paqr-2, the worm homolog of the adiponectin receptors AdipoR1/2, or its newly identified functional partner iglr-2, are glucose intolerant and die in the presence of as little as 20 mM glucose. Using FRAP (Fluorescence Recovery After Photobleaching) on living worms, we found that cultivation in the presence of glucose causes a decrease in membrane fluidity in paqr-2 and iglr-2 mutants and that genetic suppressors of this sensitivity act to restore membrane fluidity by promoting fatty acid desaturation. The essential roles of paqr-2 and iglr-2 in the presence of glucose are completely independent from daf-2 and daf-16, the C. elegans homologs of the insulin receptor and its downstream target FoxO, respectively. Using bimolecular fluorescence complementation, we also show that PAQR-2 and IGLR-2 interact on plasma membranes and thus may act together as a fluidity sensor that controls membrane lipid composition. PMID:27082444

  9. Graphene–gold nanoparticle composite: Application as a good scaffold for construction of glucose oxidase biosensor

    Energy Technology Data Exchange (ETDEWEB)

    Sabury, Sina [Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran (Iran, Islamic Republic of); Kazemi, Sayed Habib, E-mail: habibkazemi@iasbs.ac.ir [Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 45137-66731 (Iran, Islamic Republic of); Sharif, Farhad [Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran (Iran, Islamic Republic of)

    2015-04-01

    In the present work we report a facile method for fabrication of glucose oxidase immobilized on the partially reduced graphene–gold nanocomposite (PRGO–AuNPs/GOx) as a novel biosensor for determination of glucose concentration. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were used to study the morphology of PRGO and PRGO–AuNPs. Also, fast Fourier transformation infrared spectroscopy (FTIR) and UV–Vis spectroscopy were used to confirm formation of graphene and graphene–gold composite. Then, the electrochemical behavior of PRGO–AuNPs/GOx modified electrode was studied by cyclic voltammetry (CV). Our electrochemical studies, especially chronoamperometry (CA), showed that the PRGO–AuNPs/GOx modified electrode has excellent electrocatalytic activity towards the glucose. The limit of detection and sensitivity towards glucose were estimated as 0.06 μM and 15.04 mA mM{sup −1}, respectively. - Highlights: • PGRO–AuNPs modified electrode employed as a reliable scaffold for GODx immobilization. • AuNPs prevent stacking PRGO layers, thus improve the electrochemical behavior of biosensor. • GODx electron transfer was improved because of good interaction with PRGO–AuNP scaffold. • PRGO–AuNP/GODx modified biosensor showed excellent sensitivity towards glucose.

  10. Caenorhabditis elegans PAQR-2 and IGLR-2 Protect against Glucose Toxicity by Modulating Membrane Lipid Composition.

    Science.gov (United States)

    Svensk, Emma; Devkota, Ranjan; Ståhlman, Marcus; Ranji, Parmida; Rauthan, Manish; Magnusson, Fredrik; Hammarsten, Sofia; Johansson, Maja; Borén, Jan; Pilon, Marc

    2016-04-01

    In spite of the worldwide impact of diabetes on human health, the mechanisms behind glucose toxicity remain elusive. Here we show that C. elegans mutants lacking paqr-2, the worm homolog of the adiponectin receptors AdipoR1/2, or its newly identified functional partner iglr-2, are glucose intolerant and die in the presence of as little as 20 mM glucose. Using FRAP (Fluorescence Recovery After Photobleaching) on living worms, we found that cultivation in the presence of glucose causes a decrease in membrane fluidity in paqr-2 and iglr-2 mutants and that genetic suppressors of this sensitivity act to restore membrane fluidity by promoting fatty acid desaturation. The essential roles of paqr-2 and iglr-2 in the presence of glucose are completely independent from daf-2 and daf-16, the C. elegans homologs of the insulin receptor and its downstream target FoxO, respectively. Using bimolecular fluorescence complementation, we also show that PAQR-2 and IGLR-2 interact on plasma membranes and thus may act together as a fluidity sensor that controls membrane lipid composition.

  11. Tungsten oxide-Au nanosized film composites for glucose oxidation and sensing in neutral medium.

    Science.gov (United States)

    Gougis, Maxime; Ma, Dongling; Mohamedi, Mohamed

    2015-01-01

    In this work, we report for the first time the use of tungsten oxide (WOx) as catalyst support for Au toward the direct electrooxidation of glucose. The nanostructured WOx/Au electrodes were synthesized by means of laser-ablation technique. Both micro-Raman spectroscopy and transmission electron microscopy showed that the produced WOx thin film is amorphous and made of ultrafine particles of subnanometer size. X-ray diffraction and X-ray photoelectron spectroscopy revealed that only metallic Au was present at the surface of the WOx/Au composite, suggesting that the WOx support did not alter the electronic structure of Au. The direct electrocatalytic oxidation of glucose in neutral medium such as phosphate buffered saline (pH 7.2) solution has been investigated with cyclic voltammetry, chronoamperometry, and square-wave voltammetry. Sensitivity as high as 65.7 μA cm(-2) mM(-1) up to 10 mM of glucose and a low detection limit of 10 μM were obtained with square-wave voltammetry. This interesting analytical performance makes the laser-fabricated WOx/Au electrode potentially promising for implantable glucose fuel cells and biomedical analysis as the evaluation of glucose concentration in biological fluids. Finally, owing to its unique capabilities proven in this work, it is anticipated that the laser-ablation technique will develop as a fabrication tool for chip miniature-sized sensors in the near future.

  12. Body size and composition of National Football League players.

    Science.gov (United States)

    Kraemer, William J; Torine, Jon C; Silvestre, Ricardo; French, Duncan N; Ratamess, Nicholas A; Spiering, Barry A; Hatfield, Disa L; Vingren, Jakob L; Volek, Jeff S

    2005-08-01

    The purpose of this study was to present a profile of body size and composition of National Football League (NFL) players prior to the start of the regular season. Fifty-three members of the Indianapolis Colts professional football team were measured for height, body mass, and percentage body fat using the BOD POD air-displacement plethysmography system during summer camp of the 2003 football season. These data were categorized by position for comparison with previous studies of NFL football players. The relationships observed were as follows (= represents nonsignificant; > represents p Linebackers > Running Backs = Wide Receivers = Defensive Backs. Body Mass: Offensive Line = Defensive Line > Tight Ends = Linebackers > Running Backs = Quarterbacks/ Kickers/Punters > Wide Receivers = Defensive Backs. Percentage Body Fat: Offensive Line > Defensive Line > Quarterbacks/ Kickers/Punters = Linebackers = Tight Ends > Running Backs = Wide Receivers = Defensive Backs. Comparisons to teams in the 1970s indicate that body mass has increased only for offensive and defensive linemen; however, height and body fat among player positions have not dramatically changed. Furthermore, the body mass index is not an accurate measure or representation of body fat or obesity in NFL players. These data provide a basic template for size profiles and differences among various positions and allow comparisons with other studies for changes in the NFL over the past 3 decades.

  13. Body composition at birth and height at 2 years

    DEFF Research Database (Denmark)

    Admassu, Bitiya; Wells, Jonathan C; Girma, Tsinuel

    2017-01-01

    BACKGROUND: Low birth weight is associated with childhood stunting, but equivalent associations for birth body composition (BC) remain unknown. OBJECTIVE: To assess associations of BC with height-for-age Z score (HAZ) at 2 years of age. METHODS: In a prospective cohort study, fat mass (FM) and fa...... article preview online, 19 April 2017. doi:10.1038/pr.2017.59....

  14. Body composition, dietary intake and supplement use among ...

    African Journals Online (AJOL)

    Body composition is a very important aspect of an athlete's perfor- mance. According to ... inadequate diet, reduced absorption by the gastro-intestinal tract, increased excretion in ..... Obesity Research 2005;13(3):626-634. 4. Kyle UG, Bosaeus ...

  15. Body composition and physical function in women with multiple sclerosis

    Directory of Open Access Journals (Sweden)

    Christie L. Ward, MS

    2013-11-01

    Full Text Available Persons with multiple sclerosis (MS have reduced physical activity (PA and lower-limb physical function and potentially disordered body composition compared with their peers without MS. The aim of this study was to determine whether PA and body composition were differentially associated with lower-limb physical function in persons with MS compared with controls. Females with MS and age- and body mass index-matched female controls (n = 51; average age 48.1 +/– 9.7 yr were measured for PA with daily step counts, relative fat mass (%Fat, and leg lean mass (LM-LEG via dual energy X-ray absorptiometry and for lower-limb physical function with objective performance tests. Persons with MS had 12.5% to 53% poorer lower-limb physical function than controls (all p < 0.05. PA, %Fat, and LM-LEG to body mass ratio (LM-LEG/BM were associated with lower-limb physical function in both persons with MS and controls (all p < 0.05. Based on median splits, higher %Fat, lower LM-LEG/BM, and MS conferred poorer lower-limb physical function (all p < 0.05. PA, %Fat, and LM-LEG/BM were associated with lower-limb physical function, suggesting that body composition, specifically reducing adiposity and increasing lean mass and/or increasing PA levels, may be a potential target for MS interventions.

  16. Childhood thyroid function, body composition and cardiovascular function.

    Science.gov (United States)

    Barjaktarovic, Mirjana; Korevaar, Tim I M; Gaillard, Romy; de Rijke, Yolanda B; Visser, Theo J; Jaddoe, Vincent W V; Peeters, Robin P

    2017-10-01

    The cardiovascular system is a known target for thyroid hormone. Early-life cardiovascular alterations may lead to a higher risk of cardiovascular disease in adulthood. Little is known about the effects of thyroid hormone on cardiovascular function during childhood, including the role of body composition in this association. Population-based prospective cohort of children (n = 4251, median age 6 years, 95% range: 5.7-8.0 years). Thyroid-stimulating hormone (TSH) and free thyroxine (FT4) concentrations were measured to assess thyroid function. Left ventricular (LV) mass was assessed with echocardiography. Arterial stiffness was assessed with carotid-femoral pulse wave velocity (CFPWV). Systolic and diastolic blood pressure (BP) was measured. Body composition was assessed by dual-energy X-ray absorptiometry scan. FT4 was inversely associated with LV mass (P = 0.002), and with lean body mass (P cardiovascular function during early childhood. © 2017 European Society of Endocrinology.

  17. Relationship Between Diet and Body Composition After Biliopancreatic Diversion.

    Science.gov (United States)

    Calleja-Fernández, Alicia; Pintor-de-la-Maza, Begoña; Diez-Rodríguez, Rubén; Vidal-Casariego, Alfonso; Urioste-Fondo, Ana; Cano-Rodríguez, Isidoro; Ballesteros-Pomar, María D

    2015-11-01

    Biliopancreatic diversion (BPD) has been shown to be one of the most effective techniques for losing weight, although the relationship between body composition and diet after the procedure is not well known. Our aim was to assess dietary changes and their effects on body composition. This longitudinal study included all patients eligible for BPD who had undergone body composition analysis. Two assessments were performed: 6 weeks before and 1 year after surgery. Nutritional education was given after surgery by a registered dietitian, and dual energy X-ray absorptiometry was performed and a 3-day food record was collected for further analysis at both of the visits. Forty-six patients were included. The percentage of excess of weight loss was 61.03 % (SD 14.01 %), which was statistically different by gender (p = 0.045). The percentage of subjects reporting a low daily protein consumption of less than 60 g and 1.2 g/kg of ideal body weight (IBW)/day was 15.2 % before surgery and 19.6 % at 12 months (p = 0.006). The weight loss was mainly of fat mass (FM). There were differences of body composition by gender before and after surgery. A simple correlation analysis showed a significant association between daily energy intake and FM (g) only before surgery (p = 0.030), and also between daily protein intake (expressed as total g) and lean body mass (LBM) 12 months after surgery (p = 0.018), but no association was found with achieved protein goal. BPD enhanced by nutritional education seems to improve its results by achieving an adequate weight loss, preserving LBM, decreasing FM, and guaranteeing an appropriate protein intake.

  18. Adhesion molecules and chemokines: relation to anthropometric, body composition, biochemical and dietary variables

    Directory of Open Access Journals (Sweden)

    Renata Adrielle Lima Vieira

    2014-08-01

    Full Text Available Introduction: Among the inflammatory mediators involved in the pathogenesis of obesity, the cell adhesion molecules P-selectin, E-selectin, VCAM-1, ICAM-1 and the chemokine MCP-1 stand out. They play a crucial role in adherence of cells to endothelial surfaces, in the integrity of the vascular wall and can be modulated by body composition and dietary pattern. Objectives: To describe and discuss the relation of these cell adhesion molecules and chemokines to anthropometric, body composition, dietary and biochemical markers. Methods: Papers were located using scientific databases by topic searches with no restriction on year of publication. Results: All molecules were associated positively with anthropometric markers, but controversial results were found for ICAM-1 and VCAM-1. Not only obesity, but visceral fat is more strongly correlated with E-selectin and MCP-1 levels. Weight loss influences the reduction in the levels of these molecules, except VCAM-1. The distribution of macronutrients, excessive consumption of saturated and trans fat and a Western dietary pattern are associated with increased levels. The opposite could be observed with supplementation of w-3 fatty acid, healthy dietary pattern, high calcium diet and high dairy intake. Regarding the biochemical parameters, they have inverse relation to HDLC and positive relation to total cholesterol, triglycerides, blood glucose, fasting insulin and insulin resistance. Conclusion: Normal anthropometric indicators, body composition, biochemical parameters and eating pattern positively modulate the subclinical inflammation that results from obesity by reducing the cell adhesion molecules and chemokines.

  19. BODY COMPOSITION ASSESSMENT WITH SEGMENTAL MULTIFREQUENCY BIOIMPEDANCE METHOD

    Directory of Open Access Journals (Sweden)

    Jukka A. Salmi

    2003-12-01

    Full Text Available Body composition assessment is an important factor in weight management, exercise science and clinical health care. Bioelectrical impedance analysis (BIA is widely used method for estimating body composition. The purpose of this study was to evaluate segmental multi-frequency bioimpedance method (SMFBIA in body composition assessment with underwater weighing (UWW and whole body dual energy x-ray absorptiometry (DXA in healthy obese middle-aged male subjects. The measurements were carried out at the UKK Institute for Health Promotion Research in Tampere, Finland according to standard procedures of BIA, UWW and DXA. Fifty-eight (n=58 male subjects, aged 36-53 years, body mass index (BMI 24.9-40.7, were studied. Of them forty (n=40 underwent also DXA measurement. Fat mass (FM, fat-percentage (F% and fat free mass (FFM were the primary outcome variables. The mean whole body FM (±SD from UWW was 31.5 kg (±7.3. By DXA it was 29.9 kg (±8.1 and by SMFBIA it was 25.5 kg (±7.6, respectively. The Pearson correlation coefficients (r were 0.91 between UWW and SMFBIA, 0.94 between DXA and SMFBIA and 0.91 between UWW and DXA, respectively. The mean segmental FFM (±SD from DXA was 7.7 kg (±1.0 for arms, 41.7 kg (±4.6 for trunk and 21.9 kg (±2.2 for legs. By SMFBIA, it was 8.5 kg (±0.9, 31.7 kg (±2.5 and 20.3 kg (±1.6, respectively. Pearson correlation coefficients were 0.75 for arms, 0.72 for legs and 0.77 for trunk. This study demonstrates that SMFBIA is usefull method to evaluate fat mass (FM, fat free mass (FFM and fat percentage (F% from whole body. Moreover, SMFBIA is suitable method for assessing segmental distribution of fat free mass (FFM compared to whole body DXA. The results of this study indicate that the SMFBIA method may be particularly advantageous in large epidemiological studies as being a simple, rapid and inexpensive method for field use of whole body and segmental body composition assessment

  20. Maternal Dietary Patterns during Pregnancy Are Associated with Newborn Body Composition.

    Science.gov (United States)

    Starling, Anne P; Sauder, Katherine A; Kaar, Jill L; Shapiro, Allison Lb; Siega-Riz, Anna Maria; Dabelea, Dana

    2017-07-01

    Background: Maternal dietary intake during pregnancy may influence offspring growth and adiposity. Specific dietary patterns associated with newborn adiposity have not been identified.Objective: We aimed to identify patterns of maternal dietary intake associated with gestational weight gain (GWG) and fasting glucose during pregnancy and to evaluate whether adherence to these patterns is associated with newborn adiposity.Methods: In the Healthy Start prospective cohort, dietary intake during pregnancy was assessed via 24-h recalls. Reduced-rank regression identified dietary patterns predictive of GWG and fasting glucose. Associations between dietary patterns and newborn fat mass, fat-free mass, and adiposity were estimated by using linear regression models among 764 ethnically diverse mother-infant pairs.Results: Two dietary patterns were identified. Pattern 1, correlated with greater GWG (r = 0.22, P pattern 1 (upper compared with lower tertile) predicted a greater newborn fat-free mass (61 g; 95% CI: 12, 110 g) but no difference in fat mass or adiposity. Pattern 2, correlated with greater maternal fasting glucose (r = 0.16, P pattern 2 was associated with a greater newborn birth weight (80 g; 95% CI: 15, 145 g), fat mass (33 g; 95% CI: 8, 59 g), and adiposity (0.9%; 95% CI: 0.3%, 1.6%).Conclusions: Among pregnant women, adherence to a dietary pattern characterized by an intake of poultry, nuts, cheese, and whole grains was associated with greater GWG but not maternal fasting glucose or newborn adiposity. Adherence to a pattern characterized by an intake of eggs, starchy vegetables, and nonwhole grains was associated with higher maternal fasting glucose and greater newborn adiposity. Maternal dietary patterns during pregnancy may influence newborn body composition. © 2017 American Society for Nutrition.

  1. Disassociated relation between plasma tumor necrosis factor-α, interleukin-6 and increased body weight in Amerindian women: A long-term prospective study of natural body weight variation and impaired glucose tolerance

    Directory of Open Access Journals (Sweden)

    Lindgärde Folke

    2010-06-01

    Full Text Available Abstract Background Inflammatory cytokines are linked to obesity-related insulin resistance and may predict type 2 diabetes independently of obesity. We previously reported that a majority of a cohort of 73 non-diabetic women with normal plasma (p-glucose with Amerindian heritage in Lima, Peru, during a 5-year period increased both body weight and p-glucose levels, yet p-insulin was unaltered. A high proportion of palmitoleic acid (16:1n-7 in serum (s and systolic blood pressure (SBP were independent predictors of high p-glucose. Whether cytokines also contributed is, however, not known. Methods During 5 years we prospectively investigated the relation between changed concentrations of p-tumor necrosis factor (TNF-α, p-interleukin (IL-6 and circulating insulin and glucose in relation to the natural variation of body weight. Study variables included anthropometric measurements, p-insulin, TNF-α, IL-6, SBP and the proportion of 16:1n-7 in s-fatty acid composition. Results Weight and waist differences correlated negatively to the difference in p-TNF-α but positively to differences in p-IL-6 and p-insulin, whereas the increase of p-glucose from baseline to follow-up did not correlate with changes in levels of the two cytokines. In multiple regression analysis changes of TNF-α and insulin contributed independently to the variance in weight. P-insulin at baseline and weight change were determinants of fasting p-insulin at follow-up. Multiple regression analysis revealed that weight change (t-value = - 2.42; P = 0.018 and waist change (t-value = 2.41; P = 0.019 together with S-16:1n-7 (p Conclusion Our prospective study of Amerindian women revealed disassociations between changes in p-TNF-α and p-IL-6 in relation to variation in body weight. A high proportion of s-16:1n-7, SBP at baseline together with weight and waist changes were independent predictors of p-glucose at follow-up. The exact role of the opposite effects and clinical impact of p

  2. Effects of Growth Hormone Deficiency on Body Composition and Biomarkers of Cardiovascular Risk after Definitive Therapy for Acromegaly

    Science.gov (United States)

    Lin, E; Wexler, TL; Nachtigall, L; Tritos, N; Swearingen, B; Hemphill, L; Loeffler, J; Biller, BMK; Klibanski, A; Miller, KK

    2012-01-01

    Background Both growth hormone (GH) excess and GH deficiency are associated with body composition and biomarkers of cardiovascular risk in patients with pituitary disorders. However, the effects of developing GH deficiency after definitive treatment of acromegaly are largely unknown. Objective To determine whether development of GH deficiency after definitive therapy for acromegaly is associated with increased visceral adiposity and biomarkers of cardiovascular risk compared to GH sufficiency after definitive therapy for acromegaly. Design Cross-sectional Patients We studied three groups of subjects, all with a history of acromegaly (n=76): subjects with subsequent GH deficiency (GHD; n=31), subjects with subsequent GH sufficiency (GHS; n=25), and subjects with active acromegaly (AA; n=20). No study subjects were receiving somatostatin analogues, dopamine agonists or hGH. Measurements Body composition (by DXA), abdominal adipose tissue depots (by cross-sectional CT), total body water (by bioimpedance analysis) and carotid intima-media thickness (IMT) were measured. Fasting morning serum was collected for high-sensitivity C-reactive protein (hsCRP), lipids and lipoprotein levels. An oral glucose tolerance test was performed, and homeostasis model of assessment-insulin resistance (HOMA-IR) was calculated. Results Abdominal visceral adipose tissue, total adipose tissue, and total body fat were higher in subjects with GHD than GHS or AA (p acromegaly may adversely affect body composition and inflammatory biomarkers of cardiovascular risk but does not appear to adversely affect glucose homeostasis, lipids and lipoproteins, or other cardiovascular risk markers. PMID:22315983

  3. Latino Mothers' Cumulative Food Insecurity Exposure and Child Body Composition.

    Science.gov (United States)

    Hernandez, Daphne C

    2016-01-01

    To document whether an intergenerational transmission of food insecurity is occurring by assessing low-income foreign-born Latino mothers' experiences with food insecurity as none, once (either childhood or adulthood) or twice (during both childhood and adulthood). Also the association between maternal cumulative food insecurity and children's body composition was examined. Maternal self-reported surveys on retrospective measures of food insecurity during childhood, current measures of food insecurity, and demographics were collected from Houston-area community centers (N = 96). Children's body mass index (BMI) and waist circumference (WC) were directly assessed. Covariate-adjusted logistic regression models analyzed the association between cumulative food insecurity experiences and children's body composition. Fifty-eight percent of mothers experienced food insecurity both as a child and as an adult and 31% of the mothers experienced food insecurity either as a child or adult. Maternal cumulative exposure to food insecurity was unrelated to BMI but was negatively related to elevated WC. Although an intergenerational transmission of food insecurity does exist, maternal cumulative exposure to food insecurity does not impact children's body composition negatively in the short term. Studying the long-term effects of cumulative food insecurity exposure can provide information for the development and timing of obesity interventions.

  4. Analysis of Relationship between the Body Mass Composition and Physical Activity with Body Posture in Children

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    Justyna Wyszyńska

    2016-01-01

    Full Text Available Introduction. Excessive body mass in turn may contribute to the development of many health disorders including disorders of musculoskeletal system, which still develops intensively at that time. Aim. The aim of this study was to assess the relationship between children’s body mass composition and body posture. The relationship between physical activity level of children and the parameters characterizing their posture was also evaluated. Material and Methods. 120 school age children between 11 and 13 years were enrolled in the study, including 61 girls and 59 boys. Each study participant had the posture evaluated with the photogrammetric method using the projection moiré phenomenon. Moreover, body mass composition and the level of physical activity were evaluated. Results. Children with the lowest content of muscle tissue showed the highest difference in the height of the inferior angles of the scapulas in the coronal plane. Children with excessive body fat had less slope of the thoracic-lumbar spine, greater difference in the depth of the inferior angles of the scapula, and greater angle of the shoulder line. The individuals with higher level of physical activity have a smaller angle of body inclination. Conclusion. The content of muscle tissue, adipose tissue, and physical activity level determines the variability of the parameter characterizing the body posture.

  5. A Generic Integrated Physiologically based Whole-body Model of the Glucose-Insulin-Glucagon Regulatory System

    Science.gov (United States)

    Schaller, S; Willmann, S; Lippert, J; Schaupp, L; Pieber, T R; Schuppert, A; Eissing, T

    2013-01-01

    Models of glucose metabolism are a valuable tool for fundamental and applied medical research in diabetes. Use cases range from pharmaceutical target selection to automatic blood glucose control. Standard compartmental models represent little biological detail, which hampers the integration of multiscale data and confines predictive capabilities. We developed a detailed, generic physiologically based whole-body model of the glucose-insulin-glucagon regulatory system, reflecting detailed physiological properties of healthy populations and type 1 diabetes individuals expressed in the respective parameterizations. The model features a detailed representation of absorption models for oral glucose, subcutaneous insulin and glucagon, and an insulin receptor model relating pharmacokinetic properties to pharmacodynamic effects. Model development and validation is based on literature data. The quality of predictions is high and captures relevant observed inter- and intra-individual variability. In the generic form, the model can be applied to the development and validation of novel diabetes treatment strategies. PMID:23945606

  6. The association of body composition parameters with nonalcoholic hepatic steatosis

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    Mesut Sipahi

    2015-06-01

    Full Text Available Objective:Nonalcoholic fatty liver disease (NAFLD which is strongly correlated with obesity; has been a common worldwide health problem with the improvements in social status. Body composition studies are accepted as a simple follow-up tool for treatment of obesity. Since the correlation of body mass index (BMI with the hepatosteatosis (HS is well known; the aim of this study was to assess the usefulness of body composition parameters (BCP to determine HS on NAFLD patients; using dual bioimpedance analyzer (BIA. Methods:A total of 253 patients with diagnosis of NAFLD were included into the study. The demographic parameters such as age, sex and BMI were collected; and the ultrasonographic (US evolution was performed to determine the HS stages. The BCP, such as amount and the percentage of total body fat, fat free mass, and total body water were assessed with the dual bioimpedance analyzer. Results:There were strong significant correlations between BMI and HS, between BCP and HS (p0.05. Conclusion: According to our results, it can be concluded that BCP values may have a diagnostic value on diagnosis of NAFLD.

  7. Ethnic differences in body composition and obesity related risk factors: study in Chinese and white males living in China.

    Directory of Open Access Journals (Sweden)

    Dong Wang

    Full Text Available The purpose of this cross-sectional observational study was to identify ethnic differences in body composition and obesity-related risk factors between Chinese and white males living in China. 115 Chinese and 114 white male pilots aged 28-63 years were recruited. Fasting body weight, height and blood pressure were measured following standard procedures. Whole-body and segmental body composition were measured using an 8-contact electrode bioimpedance analysis (BIA system. Fasting serum glucose, fasting plasma total cholesterol (TC, high-density lipoprotein (HDL cholesterol, and triglycerides (TG were assessed using automatic biochemistry analyzer. After adjusting for age and body mass index (BMI, Chinese males had significantly higher percentage of body fat (PBF both with respect to whole body (Chinese: 23.7%±0.2% vs. Whites: 22.4%±0.2% and the trunk area (Chinese: 25.0%±0.3% vs. Whites: 23.2%±0.3% compared to their white counterparts. At all BMIs, Chinese males had significantly higher fasting glucose levels (Chinese: 5.7±1.0 mmol/L vs. Whites: 5.2±1.0 mmol/L but lower high-density lipoprotein levels (Chinese: 0.8±1.0 mmol/L vs. Whites: 1.0±1.0 mmol/L than white males. In addition, a marginally significantly higher diastolic blood pressure was found among Chinese men than that among white men (Chinese: 80±1.0 mmHg vs. Whites: 77±1.0 mmHg. Chinese males had more body fat and a greater degree of central fat deposition pattern than that seen in white males in the present study. Furthermore, data on blood pressure, fasting glucose and blood lipids suggest that Chinese men may be more prone to obesity-related risk factors than white men.

  8. Dehydroepiandrosterone Supplementation Combined with Whole-Body Vibration Training Affects Testosterone Level and Body Composition in Mice

    Science.gov (United States)

    Chen, Wen-Chyuan; Chen, Yi-Ming; Huang, Chi-Chang; Tzeng, Yen-Dun

    2016-01-01

    Dehydroepiandrosterone (DHEA), the most abundant sex steroid, is primarily secreted by the adrenal gland and a precursor hormone used by athletes for performance enhancement. Whole-body vibration (WBV) is a well-known light-resistance exercise by automatic adaptations to rapid and repeated oscillations from a vibrating platform, which is also a simple and convenient exercise for older adults. However, the potential effects of DHEA supplementation combined with WBV training on to body composition, exercise performance, and hormone regulation are currently unclear. The objective of the study is to investigate the effects of DHEA supplementation combined with WBV training on body composition, exercise performance, and physical fatigue-related biochemical responses and testosterone content in young-adult C57BL/6 mice. In this study, male C57BL/6 mice were divided into four groups (n = 8 per group) for 6-weeks treatment: sedentary controls with vehicle (SC), DHEA supplementation (DHEA, 10.2 mg/kg), WBV training (WBV; 5.6 Hz, 2 mm, 0.13 g), and WBV training with DHEA supplementation (WBV+DHEA; WBV: 5.6 Hz, 2 mm, 0.13 g and DHEA: 10.2 mg/kg). Exercise performance was evaluated by forelimb grip strength and exhaustive swimming time, as well as changes in body composition and anti-fatigue levels of serum lactate, ammonia, glucose, creatine kinase (CK), and blood urea nitrogen (BUN) after a 15-min swimming exercise. In addition, the biochemical parameters and the testosterone content were measured at the end of the experiment. Six-week DHEA supplementation alone significantly increased mice body weight (BW), muscle weight, testosterone level, and glycogen contents (liver and muscle) when compared with SC group. DHEA supplementation alone had no negative impact on all tissue and biochemical profiles, but could not improve exercise performance. However, WBV+DHEA supplementation also significantly decreased BW, testosterone level and glycogen content of liver, as well as serum

  9. Pasta supplemented with isolated lupin protein fractions reduces body weight gain and food intake of rats and decreases plasma glucose concentration upon glucose overload trial.

    Science.gov (United States)

    Capraro, Jessica; Magni, Chiara; Scarafoni, Alessio; Caramanico, Rosita; Rossi, Filippo; Morlacchini, Mauro; Duranti, Marcello

    2014-02-01

    The supplementation of foods with biologically active compounds can be a powerful approach for improving diet and well being. In this study we separately included in pasta matrices a concentrate of γ-conglutin, a glucose-lowering protein from Lupinus albus seeds, an isolate of the other main lupin storage proteins and ovalbumin, at a ratio corresponding to 125 mg of pure protein in 100 g of pasta. With these products we fed rats made hyperglycaemic, for 3 weeks. Among the most relevant changes measured in body and blood parameters were: (i) a significant reduction in food intake of rats fed γ-conglutin concentrate supplemented pasta and a significant limitation in the body weight increase in rats fed α, β and δ-conglutin isolate supplemented pasta, while the food conversion indices were unchanged; (ii) a reduction in glycaemia upon glucose overload trial, especially in the γ-conglutin concentrate supplemented pasta fed animals, at a dose of 45 mg per kg body weight. The correlations among the measured parameters are discussed. Overall, the results evidence the potentiality of supplementing traditional foods with exogenous nutraceutical seed proteins to control body weight gain and glycaemia.

  10. DPP4 gene variation affects GLP-1 secretion, insulin secretion, and glucose tolerance in humans with high body adiposity

    DEFF Research Database (Denmark)

    Böhm, Anja; Wagner, Robert; Machicao, Fausto

    2017-01-01

    OBJECTIVE: Dipeptidyl-peptidase 4 (DPP-4) cleaves and inactivates the insulinotropic hormones glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide, collectively termed incretins. DPP-4 inhibitors entered clinical practice as approved therapeutics for type-2 diabetes in 2006. However......-BMI interaction effects were detected (p = 0.8). After stratification for body fat content, the SNP negatively affected glucose-stimulated GLP-1 levels (p = 0.0229), insulin secretion (p = 0.0061), and glucose tolerance (p = 0.0208) in subjects with high body fat content only. CONCLUSIONS: A common variant, i......, inter-individual variance in the responsiveness to DPP-4 inhibitors was reported. Thus, we asked whether genetic variation in the DPP4 gene affects incretin levels, insulin secretion, and glucose tolerance in participants of the TÜbingen Family study for type-2 diabetes (TÜF). RESEARCH DESIGN...

  11. Scaling of adult regional body mass and body composition as a whole to height: Relevance to body shape and body mass index.

    Science.gov (United States)

    Schuna, John M; Peterson, Courtney M; Thomas, Diana M; Heo, Moonseong; Hong, Sangmo; Choi, Woong; Heymsfield, Steven B

    2015-01-01

    Adult body mass (MB) empirically scales as height (Ht) squared (MB ∝ Ht(2) ), but does regional body mass and body composition as a whole also scale as Ht(2) ? This question is relevant to a wide range of biological topics, including interpretation of body mass index (BMI). Dual-energy X-ray absorptiometry (DXA) was used to quantify regional body mass [head (MH), trunk, arms, and legs] and whole-body composition [fat, lean soft tissue (LST), and bone mineral content (BMC)] in non-Hispanic (NH) white, NH black, Mexican American, and Korean adults participating in the National Health and Nutrition Examination Survey (NHANES; n = 17,126) and Korean NHANES (n = 8,942). Regression models were developed to establish Ht scaling powers for each measured component with adjustments for age and adiposity. Exploratory analyses revealed a consistent scaling pattern across men and women of the four population groups: regional mass powers, head (∼0.8-1) body composition, LST (∼2.0-2.3) body mass scaled uniformly across the eight sex and population groups as Ht(∼2) , tall and short subjects differed in body shape (e.g., MH/MB ∝ Ht(-∼1) ) and composition. Adult human body shape and relative composition are a function of body size as represented by stature, a finding that reveals a previously unrecognized phenotypic heterogeneity as defined by BMI. These observations provide new pathways for exploring mechanisms governing the interrelations between adult stature, body morphology, biomechanics, and metabolism. © 2014 Wiley Periodicals, Inc.

  12. A novel oral form of salmon calcitonin improves glucose homeostasis and reduces body weight in diet-induced obese rats

    DEFF Research Database (Denmark)

    Feigh, M; Henriksen, K; Andreassen, K V

    2011-01-01

    To investigate the effects of acute and chronic administration of a novel oral formulation of salmon calcitonin (sCT) on glycaemic control, glucose homeostasis and body weight regulation in diet-induced obese (DIO) rats-an animal model of obesity-related insulin resistance and type 2 diabetes....

  13. Composition and function of P bodies in Arabidopsis thaliana

    Directory of Open Access Journals (Sweden)

    Luis David Maldonado-Bonilla

    2014-05-01

    Full Text Available mRNA accumulation is tightly regulated by diverse molecular pathways. The identification and characterization of enzymes and regulatory proteins involved in controlling the fate of mRNA offers the possibility to broaden our understanding of posttranscriptional gene regulation. Processing bodies (P bodies, PB are cytoplasmic protein complexes involved in degradation and translational arrest of mRNA. Composition and dynamics of these subcellular structures have been studied in animal systems, yeasts and in the model plant Arabidopsis. Their assembly implies the aggregation of specific factors related to decapping, deadenylation and exoribonucleases that operate synchronously to regulate certain mRNA targets during development and adaptation to stress. Although the general function of PB along with the flow of genetic information is understood, several questions still remain open. This review summarizes data on the composition, potential molecular roles, and biological significance of PB and potentially related proteins in Arabidopsis.

  14. Connection Between Body Composition and Milk Production of Lacaune Sheep

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    Tímea Ms. Kupai

    2003-09-01

    Full Text Available Five, non-related, female and male progeny groups of rams were qualified in their body composition and milk production characteristics. Body composition characteristics (fat tissue, muscle tissue and water dense substances were examined on 38 rams-to-be in 38-48 live weight with CT. Milk production data were collected from the half-sisters (n=106. According to our judgement the influence of rams can be proven statistically in both production characteristics. As we have found close (in order: r = -0,786 and r = 0,721; P<0,05 connection between daily milk production and the areas of muscle tissue and water dense substances of the carcass measured by CT, we suggest taking the correlation between them into consideration in the selection of milk production. To get a precise prediction equation, further examinations are needed.

  15. A model for estimating body shape biological age based on clinical parameters associated with body composition

    Directory of Open Access Journals (Sweden)

    Bae CY

    2012-12-01

    Full Text Available Chul-Young Bae,1 Young Gon Kang,2 Young-Sung Suh,3 Jee Hye Han,4 Sung-Soo Kim,5 Kyung Won Shim61MediAge Research Center, Seoul, Korea; 2Chaum Power Aging Center, College of Medicine, CHA University, Seoul, Korea; 3Health Promotion Center, Keimyung University Dongsam Medical Center, Daegu, Korea; 4Department of Family Medicine, College of Medicine, Eulji University, Seoul, Korea; 5Department of Family Medicine, College of Medicine, Chungnam National University, Daejeon, Korea; 6Department of Family Medicine, Ewha Womans University Mokdong Hospital, Ewha Womans University, Seoul, KoreaBackground: To date, no studies have attempted to estimate body shape biological age using clinical parameters associated with body composition for the purposes of examining a person's body shape based on their age.Objective: We examined the relations between clinical parameters associated with body composition and chronological age, and proposed a model for estimating the body shape biological age.Methods: The study was conducted in 243,778 subjects aged between 20 and 90 years who received a general medical checkup at health promotion centers at university and community hospitals in Korea from 2004 to 2011.Results: In men, the clinical parameters with the highest correlation to age included the waist-to-hip ratio (r = 0.786, P < 0.001, hip circumference (r = −0.448, P < 0.001, and height (r = −0.377, P < 0.001. In women, the clinical parameters with the highest correlation to age include the waist-to-hip ratio (r = 0.859, P < 0.001, waist circumference (r = 0.580, P < 0.001, and hip circumference (r = 0.520, P < 0.001. To estimate the optimal body shape biological age based on clinical parameters associated with body composition, we performed a multiple regression analysis. In a model estimating the body shape biological age, the coefficient of determination (R2 was 0.71 in men and 0.76 in women.Conclusion: Our model for estimating body shape biological age

  16. General many-body formalism for composite quantum particles.

    Science.gov (United States)

    Combescot, M; Betbeder-Matibet, O

    2010-05-21

    This Letter provides a formalism capable of exactly treating Pauli blocking between n-fermion particles. This formalism is based on an operator algebra made of commutators and anticommutators which contrasts with the usual scalar formalism of Green functions developed half a century ago for elementary quantum particles. We also provide the diagrams which visualize the very specific many-body physics induced by fermion exchanges between composite quantum particles.

  17. Composition of intraocular foreign bodies: experimental study of ultrasonographic presentation

    OpenAIRE

    Costa, Márcio Augusto Nogueira [UNIFESP; Garcia,Patrícia Novita; Barroso, Letícia Fernandes [UNIFESP; Ferreira, Marco Antonio; Okuda, Érika Araki [UNIFESP; Allemann,Norma

    2013-01-01

    PURPOSE: To investigate the reliability of ultrasound in determining the size and identify the sonographic features and artifacts generated by intraocular foreign bodies of different materials. METHODS: Experimental study using 36 enucleated porcine eyes. Fragments of nine different compositions (wood, glass, plastic, cardboard, iron, aluminum, lead, powder and concrete) and similar dimensions (4 mm) were implanted via scleral incision into the vitreous cavity of 36 porcine eyes, four eyes we...

  18. Electrospun graphene decorated MnCo2O4 composite nanofibers for glucose biosensing.

    Science.gov (United States)

    Zhang, Yuting; Liu, Shuai; Li, Yu; Deng, Dongmei; Si, Xiaojing; Ding, Yaping; He, Haibo; Luo, Liqiang; Wang, Zhenxin

    2015-04-15

    Graphene decorated MnCo2O4 composite nanofibers (GMCFs) were synthesized by electrospinning and subsequent calcination in an Ar atmosphere. The structural and morphological characterizations of GMCFs were performed using X-ray diffraction, Fourier transform infrared spectroscopy, Raman spectroscopy, energy-dispersive spectroscopy, scanning electron microscopy and transmission electron microscopy. The synthesized GMCFs combine the catalytic activity of spinel-type MnCo2O4 with the remarkable conductivity of graphene. In addition, electrospinning can process MnCo2O4 materials into nanosized architectures with large surface area to prevent magnetic nanoparticles from aggregating. The obtained GMCFs were applied as a novel platform for glucose biosensing. Electrochemical studies show that the developed biosensor exhibits excellent electrocatalytic activity towards glucose oxidation over a wide linear range of 0.005-800µM with a low detection limit of 0.001µM.

  19. Composition of intraocular foreign bodies: experimental study of ultrasonographic presentation.

    Science.gov (United States)

    Costa, Márcio Augusto Nogueira; Garcia, Patrícia Novita; Barroso, Letícia Fernandes; Ferreira, Marco Antonio; Okuda, Érika Araki; Allemann, Norma

    2013-01-01

    To investigate the reliability of ultrasound in determining the size and identify the sonographic features and artifacts generated by intraocular foreign bodies of different materials. Experimental study using 36 enucleated porcine eyes. Fragments of nine different compositions (wood, glass, plastic, cardboard, iron, aluminum, lead, powder and concrete) and similar dimensions (4 mm) were implanted via scleral incision into the vitreous cavity of 36 porcine eyes, four eyes were used for each material. Ultrasound examination was performed in all eyes using the contact technique, conductive gel and 10-MHz transducer (EZScan, Sonomed). Considering the material fragments of gunpowder, lead, concrete, aluminum, wood and glass, the size determined by ultrasound was considered statistically similar to the actual size. The material iron presented ultrasound-determined dimension statistically smaller than its actual size. Cardboard and plastic materials showed ultrasound-determined measurements far greater than the actual. All fragments of intraocular foreign bodies demonstrated hyper-reflective interfaces, irrespective of their composition. Whereas the artifacts generated by different materials, it was found that the materials iron, aluminum and lead showed reverberation of great extent. The material wood showed no reverberation. The length of the reverberation artifact for the materials iron, glass, aluminum and cardboard was lower when compared to other materials. All materials presented posterior shadowing artifact, with the exception of aluminum. Ultrasonography was considered a reliable technique to determine the size of intraocular foreign bodies in pigs, with little influence caused by its composition. Ultrasound artifacts generated were considered material-dependent and can assist the examiner to identify the nature of a foreign body of unknown etiology. Ultrasonography aided the surgeon to identify, locate and measure the intraocular foreign body, directing

  20. Composition of intraocular foreign bodies: experimental study of ultrasonographic presentation

    Directory of Open Access Journals (Sweden)

    Márcio Augusto Nogueira Costa

    2013-02-01

    Full Text Available PURPOSE: To investigate the reliability of ultrasound in determining the size and identify the sonographic features and artifacts generated by intraocular foreign bodies of different materials. METHODS: Experimental study using 36 enucleated porcine eyes. Fragments of nine different compositions (wood, glass, plastic, cardboard, iron, aluminum, lead, powder and concrete and similar dimensions (4 mm were implanted via scleral incision into the vitreous cavity of 36 porcine eyes, four eyes were used for each material. Ultrasound examination was performed in all eyes using the contact technique, conductive gel and 10-MHz transducer (EZScan, Sonomed. RESULTS: Considering the material fragments of gunpowder, lead, concrete, aluminum, wood and glass, the size determined by ultrasound was considered statistically similar to the actual size. The material iron presented ultrasound-determined dimension statistically smaller than its actual size. Cardboard and plastic materials showed ultrasound-determined measurements far greater than the actual. All fragments of intraocular foreign bodies demonstrated hyper-reflective interfaces, irrespective of their composition. Whereas the artifacts generated by different materials, it was found that the materials iron, aluminum and lead showed reverberation of great extent. The material wood showed no reverberation. The length of the reverberation artifact for the materials iron, glass, aluminum and cardboard was lower when compared to other materials. All materials presented posterior shadowing artifact, with the exception of aluminum. CONCLUSION: Ultrasonography was considered a reliable technique to determine the size of intraocular foreign bodies in pigs, with little influence caused by its composition. Ultrasound artifacts generated were considered material-dependent and can assist the examiner to identify the nature of a foreign body of unknown etiology. Ultrasonography aided the surgeon to identify, locate and

  1. Anorexia nervosa and nutritional assessment: contribution of body composition measurements.

    Science.gov (United States)

    Mattar, Lama; Godart, Nathalie; Melchior, Jean Claude; Pichard, Claude

    2011-06-01

    The psychiatric condition of patients suffering from anorexia nervosa (AN) is affected by their nutritional status. An optimal assessment of the nutritional status of patients is fundamental in understanding the relationship between malnutrition and the psychological symptoms. The present review evaluates some of the available methods for measuring body composition in patients with AN. We searched literature in Medline using several key terms relevant to the present review in order to identify papers. Only articles in English or French were reviewed. A brief description is provided for each body composition technique, with its applicability in AN as well as its limitation. All methods of measuring body composition are not yet validated and/or feasible in patients with AN. The present review article proposes a practical approach for selecting the most appropriate methods depending on the setting, (i.e. clinical v. research) and the goal of the assessment (initial v. follow-up) in order to have a more personalised treatment for patients suffering from AN.

  2. Dodecanedioic acid infusion induces a sparing effect on whole-body glucose uptake, mainly in non-insulin-dependent diabetes mellitus.

    Science.gov (United States)

    Mingrone, G; De Gaetano, A; Greco, A V; Capristo, E; Benedetti, G; Castagneto, M; Gasbarrini, G

    1997-11-01

    Even-numbered dicarboxylic acids (DA) have been proposed as an alternative fuel substrate in parenteral nutrition. In particular, dodecanedioic acid (C12) shows a rapid plasma clearance from tissues, a very low urinary excretion compared with other DA and a high oxidation rate. The aim of the present study was to investigate the effect of C12 infusion on insulin-stimulated glucose uptake in patients with non-insulin-dependent diabetes mellitus (NIDDM) compared with healthy volunteers. A primed-constant infusion of C12 (0.39 mmol/min) was administered over 240 min, and at 120 min a 2 h euglycaemic hyperinsulinaemic clamp was performed. Blood specimens were sampled every 30 min and fractioned urines were collected over 24 h. The levels of C12 were measured by HPLC. Indirect calorimetry was performed continuously during the entire session. Body composition was assessed in all subjects studied to obtain fat-free mass (FFM) values. Whole-body glucose uptake decreased significantly during C12 infusion in both groups, although this effect was much more evident (P < 0.01) in NIDDM patients (52.4 (SD 15.8) % decrease compared with saline) than in controls (25.9 (SD 12.1) % decrease). The M value (mumol/kgFFM per min) was reduced by C12 to lower levels in NIDDM patients than in normal controls (12.6 (SD 3.9) v. 25.9 (SD 4.5), P < 0.01). Urinary excretion of C12 over 24 h was significantly lower in NIDDM patients than in controls (4.26 (SD 0.30) mmol v. 5.43 (SD 0.48), P < 0.01), corresponding to less than 3% of the administered dose. The infusion of C12 decreased non-protein RQ significantly in both groups of patients. In conclusion, this study shows, for the first time, that C12 significantly reduces glucose uptake in both normal controls and NIDDM patients, although this sparing effect on glucose uptake is much more pronounced in diabetic patients. These data suggest that C12 decreases glucose uptake and oxidation, mainly through a mechanism of substrate competition. Thus

  3. Effect of age on body composition in healthy Beijing women

    Institute of Scientific and Technical Information of China (English)

    Chen Rong; Lin Shou-qing; Lin Xia; Chen Yan; Yang Qiu-hong; Zhou Yong; Zhang Ying

    2011-01-01

    Objective:To explore the effect of age on body composition in healthy Beijing women.Methods:We measured body composition with dual-energy X-ray (GE Lunar Prodigy) in 316 healthy Beijing females aged 20 to 74 years (5-7 women per age).Parameters provided by the software were as following:total body bone mineral content (BMC),lean mass (LM),fat mass and fat mass percentage (FM%).Local regions measured included arm,leg,trunk,android region and gynoid region.Body mass index (BMI),fat mass index (FMI),free fat mass index (FFMI) and A/G were calculated.Volunteers were assigned to 6 groups according to age by every ten years a group.Results..BMC peaked during the 4th decade,LM peaked during the 5th decade,with a decline of 18.1% and 5.2% respectively at age 74 years.Total body fat mass and FM% showed a general increase with aging throughout the studied age range.Total body fat mass increased from (16±5) kg at age 20-29 years to (24±6)kg at age 70-74years,while FM% increased from 31.3% to 39.5%.All local region FM% increased with aging at different extents.Android region FM% showed the largest raise extent (32.2%).BMI increased gradually from 21.1 kg/m2 at age 20-29 years to 26.1 kg/m2 at age 70-74 years.FMI changed more obviously than FFMI.A/G increased from 0.85 at age 20-29 years to 1.02 at age 70-74 years.Different menstrual status in women of 40-59 years had obvious effect on A/G and BMC (P<0.05),while it had no significant effect on BMI,body weight and waist circumference (P>0.05).Conclusion:Aging has a great effect on body composition distribution in healthy Beijing women.

  4. Body composition and nutritional profile of male adolescent tennis players.

    Science.gov (United States)

    Juzwiak, Claudia R; Amancio, Olga M S; Vitalle, Maria S S; Pinheiro, Marcelo M; Szejnfeld, Vera L

    2008-09-01

    In this cross-sectional study, we evaluated the body composition and dietary intake of 44 adolescent tennis players. After being divided into two groups (age 10-13 years and age 14-18), the players had their weight, height, and sexual maturation assessed. Dual-energy X-ray absorptiometry was used to assess body composition. Food intake was obtained from a non-consecutive 4-day food record. The data were analysed using the Virtual Nutri v.1.0 software and compared with the present recommendations for adolescent athletes or dietary reference intakes. Body mass index and body fat for tennis practice were adequate for 89% and 71% of the tennis players respectively, regardless of age group. A calorie deficit greater than 10% of energy expenditure was observed in 32% of the sample. Fifty percent of the athletes consumed carbohydrates in accordance with recommended values. Protein and lipid intakes were above recommended values, while fibre, calcium, potassium, magnesium, and folic acid intakes were below recommendation for 98%, 80%, 100%, 100%, and 98% of the tennis players respectively. The observed nutritional deficiencies represent an additional barrier for adolescents engaged in competitive sports to achieve an optimum nutrition to maintain growth, health, and performance.

  5. Somatotype and Body Composition of Normal and Dysphonic Adult Speakers.

    Science.gov (United States)

    Franco, Débora; Fragoso, Isabel; Andrea, Mário; Teles, Júlia; Martins, Fernando

    2017-01-01

    Voice quality provides information about the anatomical characteristics of the speaker. The patterns of somatotype and body composition can provide essential knowledge to characterize the individuality of voice quality. The aim of this study was to verify if there were significant differences in somatotype and body composition between normal and dysphonic speakers. Cross-sectional study. Anthropometric measurements were taken of a sample of 72 adult participants (40 normal speakers and 32 dysphonic speakers) according to International Society for the Advancement of Kinanthropometry standards, which allowed the calculation of endomorphism, mesomorphism, ectomorphism components, body density, body mass index, fat mass, percentage fat, and fat-free mass. Perception and acoustic evaluations as well as nasoendoscopy were used to assign speakers into normal or dysphonic groups. There were no significant differences between normal and dysphonic speakers in the mean somatotype attitudinal distance and somatotype dispersion distance (in spite of marginally significant differences [P speakers. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  6. Body composition and somatotype of experienced mountain climbers.

    Science.gov (United States)

    Barbieri, Davide; Zaccagni, Luciana; Cogo, Annalisa; Gualdi-Russo, Emanuela

    2012-03-01

    In order to evaluate body composition and somatotype, 10 Italian experienced mountain climbers were assessed from an anthropometric point of view, before a high altitude ascent. Body mass, height, girths, skinfolds, and bone breadths were gathered and used to calculate body composition and somatotype of each subject. Means and standard deviations of the subjects' anthropometric characteristics were calculated. Mesomorphism (5.28±1.10) is the dominant somatotype component in all but one the participants, endomorphism (1.55±0.49) is low, and body fat percentage (11.76%±2.93) is low. Comparisons with athletes involved in other climbing subdisciplines highlight the specificity of elite mountain climbers anthropometry. The elite mountain climbers in our sample were predominantly mesomorphic with somatotype attitudinal mean values lower than reported for male athletes participating in free-climbing, volleyball, gymnastics, and soccer. Anthropometric characteristics may therefore play a role in mountain climbing, even though the trainable components may be more relevant than the nontrainable ones.

  7. A comparison between CLNA and CLA effects on body fat, serum parameters and liver composition.

    Science.gov (United States)

    Miranda, J; Fernández-Quintela, A; Macarulla, M T; Churruca, I; García, C; Rodríguez, V M; Simón, E; Portillo, M P

    2009-03-01

    The potential of conjugated linoleic acid (CLA) as an anti-obesity molecule for humans is still a matter for debate. Thus, a great deal of scientific work is focussed on the research of new effective molecules without deleterious effects on health. The aim of the present work was to analyse the effects of jacaranda seed oil, rich in a conjugated linolenic acid (CLNA), jacaric acid (cis-8,trans-10,cis-12), on body fat, serum parameters and liver composition in rats, and to compare these effects with those of trans-10,cis-12 CLA. Twenty-six male Wistar rats were divided into three groups fed with high-fat diets, supplemented or not (control group) with 0.5% trans-10,cis-12 CLA (CLA group) or 0.5% jacaric acid (CLNA group) for 7 weeks. No statistical differences in food intake or in final body weight were found. Whereas CLA reduced adipose tissue size, CLNA did not. Both CLA and CLNA significantly reduced non-HDL-cholesterol. In spite of a lack of significant changes in glucose and insulin levels, HOMA-IR index was significantly increased, as well as did non-esterified fatty acid levels in CLNA-fed rats. No changes in liver composition were observed. In conclusion, under our experimental conditions, jacaric acid, unlike CLA, does not show a body-fat lowering effect. Even though it leads to a healthy lipoprotein profile, it impairs insulin function. Consequently, it cannot be proposed as an anti-obesity molecule.

  8. A review on effects of conjugated linoleic fatty acid (CLA) upon body composition and energetic metabolism.

    Science.gov (United States)

    Lehnen, Tatiana Ederich; da Silva, Marcondes Ramos; Camacho, Augusto; Marcadenti, Aline; Lehnen, Alexandre Machado

    2015-01-01

    Conjugated linoleic acid (CLA) is highly found in fats from ruminants and it appears to favorably modify the body composition and cardiometabolic risk factors. The capacity of CLA to reduce the body fat levels as well as its benefic actions on glycemic profile, atherosclerosis and cancer has already been proved in experimental models. Furthermore, CLA supplementation may modulate the immune function, help re-synthetize of glycogen and potentiate the bone mineralization. CLA supplementation also could increase the lipolysis and reduce the accumulation of fatty acids on the adipose tissue; the putative mechanisms involved may be its action in reducing the lipase lipoprotein activity and to increase the carnitine-palmitoil-transferase-1 (CAT-1) activity, its interaction with PPARγ, and to raise the expression of UCP-1. Although studies made in human have shown some benefits of CLA supplementation as the weight loss, the results are still discordant. Moreover, some have shown adverse effects, such as negative effects on glucose metabolism and lipid profile. The purpose of this article is to review the available data regarding the benefits of CLA on the energetic metabolism and body composition, emphasizing action mechanisms.

  9. Lipid metabolism and body composition in Gclm(-/-) mice

    Energy Technology Data Exchange (ETDEWEB)

    Kendig, Eric L. [Department of Environmental Health, University of Cincinnati Medical Center, P.O. Box 670056, Cincinnati, OH 45267 (United States); Center for Environmental Genetics, University of Cincinnati Medical Center, P.O. Box 670056, Cincinnati, OH 45267 (United States); Chen, Ying [Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, Aurora, CO 80045 (United States); Krishan, Mansi; Johansson, Elisabet; Schneider, Scott N. [Department of Environmental Health, University of Cincinnati Medical Center, P.O. Box 670056, Cincinnati, OH 45267 (United States); Genter, Mary Beth; Nebert, Daniel W. [Department of Environmental Health, University of Cincinnati Medical Center, P.O. Box 670056, Cincinnati, OH 45267 (United States); Center for Environmental Genetics, University of Cincinnati Medical Center, P.O. Box 670056, Cincinnati, OH 45267 (United States); Shertzer, Howard G., E-mail: shertzhg@ucmail.uc.edu [Department of Environmental Health, University of Cincinnati Medical Center, P.O. Box 670056, Cincinnati, OH 45267 (United States); Center for Environmental Genetics, University of Cincinnati Medical Center, P.O. Box 670056, Cincinnati, OH 45267 (United States)

    2011-12-15

    In humans and experimental animals, high fat diets (HFD) are associated with risk factors for metabolic diseases, such as excessive weight gain and adiposity, insulin resistance and fatty liver. Mice lacking the glutamate-cysteine ligase modifier subunit gene (Gclm(-/-)) and deficient in glutathione (GSH), are resistant to HFD-mediated weight gain. Herein, we evaluated Gclm-associated regulation of energy metabolism, oxidative stress, and glucose and lipid homeostasis. C57BL/6J Gclm(-/-) mice and littermate wild-type (WT) controls received a normal diet or an HFD for 11 weeks. HFD-fed Gclm(-/-) mice did not display a decreased respiratory quotient, suggesting that they are unable to process lipid for metabolism. Although dietary energy consumption and intestinal lipid absorption were unchanged in Gclm(-/-) mice, feeding these mice an HFD did not produce excess body weight nor fat storage. Gclm(-/-) mice displayed higher basal metabolic rates resulting from higher activities of liver mitochondrial NADH-CoQ oxidoreductase, thus elevating respiration. Although Gclm(-/-) mice exhibited strong systemic and hepatic oxidative stress responses, HFD did not promote glucose intolerance or insulin resistance. Furthermore, HFD-fed Gclm(-/-) mice did not develop fatty liver, likely resulting from very low expression levels of genes encoding lipid metabolizing enzymes. We conclude that Gclm is involved in the regulation of basal metabolic rate and the metabolism of dietary lipid. Although Gclm(-/-) mice display a strong oxidative stress response, they are protected from HFD-induced excessive weight gain and adipose deposition, insulin resistance and steatosis. -- Highlights: Black-Right-Pointing-Pointer A high fat diet does not produce body weight and fat gain in Gclm(-/-) mice. Black-Right-Pointing-Pointer A high fat diet does not induce steatosis or insulin resistance in Gclm(-/-) mice. Black-Right-Pointing-Pointer Gclm(-/-) mice have high basal metabolism and mitochondrial

  10. Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.

    Science.gov (United States)

    Legette, Leecole L; Luna, Arlyn Y Moreno; Reed, Ralph L; Miranda, Cristobal L; Bobe, Gerd; Proteau, Rosita R; Stevens, Jan F

    2013-07-01

    Obesity contributes to increased risk for several chronic diseases including cardiovascular disease and type 2 diabetes. Xanthohumol, a prenylated flavonoid from hops (Humulus lupulus), was tested for efficacy on biomarkers of metabolic syndrome in 4 week old Zucker fa/fa rats, a rodent model of obesity. Rats received daily oral doses of xanthohumol at 0, 1.86, 5.64, and 16.9 mg/kg BW for 6 weeks. All rats were maintained on a high fat (60% kcal) AIN-93G diet for 3 weeks to induce severe obesity followed by a normal AIN-93G (15% kcal fat) diet for the last 3 weeks of the study. Weekly food intake and body weight were recorded. Plasma cholesterol, glucose, insulin, triglyceride, and monocyte chemoattractant protein-1 (MCP-1) levels were assessed using commercial assay kits. Plasma and liver tissue levels of XN and its metabolites were determined by liquid-chromatography tandem mass spectrometry. Plasma and liver tissue levels of xanthohumol were similar between low and medium dose groups and significantly (pxanthohumol, which was also not seen for female rats. Plasma cholesterol, insulin, triglycerides, and MCP-1 as well as food intake were not affected by treatment. The findings suggest that xanthohumol has beneficial effects on markers of metabolic syndrome.

  11. Body Mass Index (BMI) and Glucose Intolerance during Pregnancy in White European Women.

    Science.gov (United States)

    Farah, Nadine; McGoldrick, Aoife; Fattah, Chro; O'Connor, Norah; Kennelly, Mairead M; Turner, Michael J

    2012-04-01

    The risk of gestational diabetes mellitus (GDM) in accordance to Body Mass Index (BMI) is often based on studies where the calculation of BMI is frequently self-reported and is usually unreliable. We evaluated the risk of an abnormal oral glucose tolerance test (OGTT) in a population where BMI was measured and selective screening for GDM was practiced. We carried out a prospective observational study where 1935 white European women with a singleton pregnancy were recruited. In the first trimester maternal height and weight were measured digitally. Statistical analysis was performed using SPSS version 15.0. BMI centiles were calculated from the study population. A Chi-square test was used to test the differences in categorical variables between the groups. A p-value BMI ≥90th centile (≥33.1 kg/m (2) ) compared to women with a BMI between the 80th and 90th centiles (≥29.3 and BMI is measured, we recommend to increase the cut-off point for selective screening of GDM to ≥33.0 kg/m (2) . This may decrease unnecessary obstetric interventions and healthcare costs.

  12. Glucose sensing in transdermal body fluid collected under continuous vacuum pressure via micropores in the stratum corneum.

    Science.gov (United States)

    Gebhart, Suzanne; Faupel, Mark; Fowler, Richard; Kapsner, Candis; Lincoln, Daniel; McGee, Valarie; Pasqua, John; Steed, Leigh; Wangsness, Michael; Xu, Fan; Vanstory, Madeleine

    2003-01-01

    Application of continuous vacuum pressure on skin perforated with tiny micropores created by a focused beam from a low-cost laser system can result in access to a clear, transdermal body fluid (TDF) for the continuous measurement of glucose in vivo. Two clinical studies were performed to assess the feasibility of this approach. In the first study, 56 diabetic subjects were porated on either the arm or abdomen, and glucose was measured in their TDF using a custom assay system contained in a patch that was affixed to the skin above the poration site. The continuous readings of glucose in TDF were compared with fingerstick blood measured every half-hour over a 2-day period, resulting in 1,167 paired data points that yielded a correlation of 0.8745 with 97.75% of the readings in the Clarke Error Grid A and B zones. In a second study, 187 diabetic and 65 nondiabetic subjects had glucose measurements from their TDF made using a commercially available glucose strip and meter. A total of 4,059 data pairs (discrete TDF and capillary blood) were collected over a 2-day period, resulting in a correlation of 0.946 with 99% of the readings in the Clarke Error Grid A and B zones. These studies indicate that TDF drawn through micropores in the stratum corneum of the skin potentially can provide a lesser invasive and continuous method of measuring glucose in diabetic individuals.

  13. Morphological tuned preparation of zinc oxide: reduced graphene oxide composites for non-enzymatic fluorescence glucose sensing and enhanced photocatalysis

    Science.gov (United States)

    Sivalingam, Muthu Mariappan; Balasubramanian, Karthikeyan

    2016-07-01

    Zinc oxide: reduced graphene oxide (ZnO:rgo) composites with varying ZnO morphologies have been synthesized towards the application of non-enzymatic fluorescence (FL) glucose sensor and photocatalysis for methylene blue (MB) degradation. The phase structure of ZnO has confirmed by X-ray diffraction studies, and the band gap calculations were done by UV absorption spectra. Scanning electron microscope and Raman spectra revealed the morphological change and the vibrational studies of the prepared samples, respectively. The quenching of the FL emission band of ZnO:rgo composite sample confirmed the transfer of electrons from ZnO to rgo which inhibit the exciton recombination process. The non-enzymatic FL glucose sensing was carried out by the addition of dextrose glucose ( d-glucose) into the ZnO:rgo composite solution, which shows strong relationship between glucose concentration and the FL intensity. The photocatalytic studies showed that composite with high surface to volume ratio exhibits a maximum degradation of MB over 93 %. Our combined results ensured that the ZnO:rgo composites with varying morphologies could be an effective system for applications such as FL-based glucose sensing and photocatalytic degradation.

  14. Body mass index and body composition among rescue firefighters personnel in Selangor, Malaysia

    Science.gov (United States)

    Rahimi, Nor Atiqah; Sedek, Razalee; Teh, Arnida Hani

    2016-11-01

    Obesity is a major public health problem in general population and there is no exception for firefighters. This disorder is definitely a burden for firefighters as they needed to be physically fit in order to work in dangerous situation and extinguishing fires. The purposes of this study were to determine physical characteristics and body composition among Malaysian Firefighters (MF) and to explore their association. This cross-sectional study involved 330 rescue firefighters aged between 20-50 years old from nine different districts in Selangor conducted between August and November 2015. Anthropometric measurements included height, weight and waist circumference (WC). Body composition was measured using bioelectrical impedance. The mean height, weight, body mass index (BMI), WC and body fat percentage were 169.4±5.3 cm, 74.5±12.2 kg, 25.9±3.82 kg/m2, 90.7±48.3 cm and 25.8±6.2 % respectively. The results also showed that 0.6% of them were underweight, 41.5% were normal, 44.8% were overweight and 13% were obese. The percentage of 34.8% firefighters with WC values of more than 90 cm means that they were at greater risk to have cardiovascular and diabetes disease. Body composition analysis showed that 75.5% of the subjects have high body fat level, 19.7% subjects were in healthy range but only 4.8% were considered as lean subjects. BMI was highly correlated with weight (r=0.917, peducated and have longer duration of services. It can be concluded that more than half of the firefighter personnel were either overweight or obese and 35% of them were at greater risk of having non-communicable diseases. This study provides useful information and serves as a source of reference for planning health related program for MF personnel to prevent non-communicable disease among firefighters population.

  15. Relation of Serial Changes in Childhood Body-Mass Index to Impaired Glucose Tolerance in Young Adulthood

    Science.gov (United States)

    Bhargava, Santosh K.; Sachdev, Harshpal Singh; Fall, Caroline H.D.; Osmond, Clive; Lakshmy, Ramakrishnan; Barker, David J.P.; Biswas, Sushant K. Dey; Ramji, Siddharth; Prabhakaran, Dorairaj; Reddy, Kolli Srinath

    2012-01-01

    BACKGROUND The risk of type 2 diabetes mellitus is increased in people who have low birth weights and who subsequently become obese as adults. Whether their obesity originates in childhood and, if so, at what age are unknown. Understanding the origin of obesity may be especially important in developing countries, where type 2 diabetes is rapidly increasing yet public health messages still focus on reducing childhood “undernutrition.” METHODS We evaluated glucose tolerance and plasma insulin concentrations in 1492 men and women 26 to 32 years of age who had been measured at birth and at intervals of three to six months throughout infancy, childhood, and adolescence in a prospective, population-based study. RESULTS The prevalence of impaired glucose tolerance was 10.8 percent, and that of diabetes was 4.4 percent. Subjects with impaired glucose tolerance or diabetes typically had a low body-mass index up to the age of two years, followed by an early adiposity rebound (the age after infancy when body mass starts to rise) and an accelerated increase in body-mass index until adulthood. However, despite an increase in body-mass index between the ages of 2 and 12 years, none of these subjects were obese at the age of 12 years. The odds ratio for disease associated with an increase in the body-mass index of 1 SD from 2 to 12 years of age was 1.36 (95 percent confidence interval, 1.18 to 1.57; P<0.001). CONCLUSIONS There is an association between thinness in infancy and the presence of impaired glucose tolerance or diabetes in young adulthood. Crossing into higher categories of body-mass index after the age of two years is also associated with these disorders. PMID:14985484

  16. Whole body glucose kinetics in type I diabetes studied with (6,6-/sup 2/H) and (U-/sup 13/C)-glucose and the artificial B-cell

    Energy Technology Data Exchange (ETDEWEB)

    Darmaun, D.; Cirillo, D.; Koziet, J.; Chauvet, D.; Young, V.R.; Robert, J.J.

    1988-05-01

    Dynamic aspects of whole body glucose metabolism were assessed in ten young adult insulin-dependent (type I) diabetic men. Using a primed, continuous intravenous infusion of (6,6-/sup 2/H)glucose and (U-/sup 13/C)glucose, endogenous production, tissue uptake, carbon recycling, and oxidation of glucose were measured in the postabsorptive state. These studies were undertaken after blood glucose had been maintained overnight at 5.9 +/- 0.4 mmol/L (n = 10), and on another night at 10.5 +/- 0.4 mmol/L (n = 4) or 15.2 +/- 0.6 mmol/L (n = 6). In the normoglycemic state, endogenous glucose production averaged 2.15 +/- 0.13 mg x kg-1 x min-1. This value, as well as the rate of glucose carbon recycling (0.16 +/- 0.04 mg x kg-1 x min-1) and glucose oxidation (1.52 +/- 0.16 mg x kg-1 x min-1) are comparable to those found in nondiabetic controls. In the hyperglycemic states at 10 or 15 mmol/L, endogenous glucose production was increased by 11% (P less than .01) and 60% (P less than .01) compared to the normoglycemic states, respectively. Glucose carbon recycling contributed only a small percentage to this variation in glucose production (15% at the 15 mmol/L glucose level). This suggests that if gluconeogenesis participates in the increased glucose output, it is not dependent on a greater systemic supply of three-carbon precursors. The increased rate of glucose production in the hyperglycemic state was quantitatively offset by a rise in urinary glucose excretion. Glucose tissue uptake, as well as glucose oxidation, did not vary between normoglycemic and hyperglycemic states.

  17. Cardiorespiratory Fitness and Body Composition in Postmenopausal Women

    Directory of Open Access Journals (Sweden)

    Moreira Helena

    2014-12-01

    Full Text Available The object of the study was to analyze the relationship between aerobic fitness and body composition in postmenopausal women. We hypothesized that postmenopausal women that had higher adiposity had lower cardiorespiratory capacity, regardless of the characteristics of menopause. The sample included 208 women (57.57 ± 6.62 years, whose body composition and the basal metabolic rate were evaluated by octopolar bioimpedance (InBody 720 and the oxygen uptake by the modified Bruce protocol. Most of the sample showed obesity and a high visceral fat area. The visceral fat area and the basal metabolic rate explained 30% of the variation of oxygen uptake, regardless of age, time, nature or hormone therapy. The values of the latter variables were reduced in the presence of high central adiposity (-6.16 ml/kg/min and the basal metabolic rate of less than 1238 kcal/day (-0.18 ml/kg/min. The women with oxygen uptake above 30.94 ml/kg/min showed lower values of total and central adiposity when compared with other groups. With an increase of aerobic fitness, there was a growing tendency of the average values of the soft lean mass index, with differences between the groups low-high and moderate-high. These results suggest worsening of the cardiorespiratory condition with an increase of central adiposity and a decrease of the BMR, regardless of age and menopause characteristics.

  18. Body composition and physiological characteristics of law enforcement officers.

    Science.gov (United States)

    Spitler, D L; Jones, G; Hawkins, J; Dudka, L

    1987-12-01

    The physical work capacity, body composition, and physiological characteristics of 12 law enforcement officers (9 males, 3 females) were measured. Subjects included a representative sample from the occupational categories of detective, staff, investigative and patrol officer. Mean maximal oxygen uptake of the men was 42.1 +/- 8.9 ml.kg-1min-1 with mean values of 41.5 +/- 8.7 ml.kg-1min-1 for the women. Measurement of body composition indicated an average of 24.4 +/- 7.1% body fat for the men and 30.9 +/- 1.2% for the women. Muscular power, strength, and endurance as measured by isolated limb flexion-extension movement and fitness test performance was considered average with no excessive bilateral differences. The results of this study were compared with other investigations of law enforcement officers of similar age groups. The officers displayed average or above health and physical fitness scores for their age classification and were able to complete all police task-oriented tests.

  19. Plain to point network reduced graphene oxide - activated carbon composites decorated with platinum nanoparticles for urine glucose detection

    Science.gov (United States)

    Hossain, Mohammad Faruk; Park, Jae Y.

    2016-02-01

    In this study, a hydrothermal technique was applied to synthesize glucose-treated reduced graphene oxide-activated carbon (GRGO/AC) composites. Platinum nanoparticles (PtNP) were electrochemically deposited on the modified GRGO/AC surface, and chitosan-glucose oxidase (Chit-GOx) composites and nafion were integrated onto the modified surface of the working electrode to prepare a highly sensitive glucose sensor. The fabricated biosensor exhibited a good amperometric response to glucose in the detection range from 0.002 mM to 10 mM, with a sensitivity of 61.06 μA/mMcm2, a short response time (4 s) and a low detection limit of 2 μM (signal to noise ratio is 3). The glucose sensor exhibited a negligible response to interference and good stability. In addition, the glucose levels in human urine were tested in order to conduct a practical assessment of the proposed sensor, and the results indicate that the sensor had superior urine glucose recognition. These results thus demonstrate that the noble nano-structured electrode with a high surface area and electrocatalytic activity offers great promise for use in urine glucose sensing applications.

  20. Insulin resistance, exercise capacity and body composition in subjects with two hypertensive parents

    DEFF Research Database (Denmark)

    Andersen, U B; Dige-Petersen, H; Ibsen, H

    1999-01-01

    correlated to abdominal fat mass but not to insulin sensitivity. CONCLUSION: Subjects with a strong genetic predisposition to essential hypertension had increased diastolic blood pressure compared with subjects with normotensive parents, but they were not insulin resistant. This may be due to the subjects......OBJECTIVE: To study insulin resistance in subjects with strong genetic predisposition to essential hypertension, compared with non-disposed subjects. SUBJECTS: Thirty normotensive subjects aged 18-35 years whose parents both had essential hypertension, and 30 age- and sex matched subjects whose...... parents were both normotensive, were studied. Subjects or parents with diabetes and morbid obesity were excluded. METHODS: The study comprised (1) a frequent sampling oral glucose tolerance test; (2) an isoglycemic hyperinsulinemic clamp study; (3) an analysis of body composition by dual-energy X...

  1. p53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity.

    Science.gov (United States)

    Litwak, Sara A; Loh, Kim; Stanley, William J; Pappas, Evan G; Wali, Jibran A; Selck, Claudia; Strasser, Andreas; Thomas, Helen E; Gurzov, Esteban N

    2016-04-01

    BCL-2 proteins have been implicated in the control of glucose homeostasis and metabolism in different cell types. Thus, the aim of this study was to determine the role of the pro-apoptotic BH3-only protein, p53-upregulated-modulator-of-apoptosis (PUMA), in metabolic changes mediated by diet-induced obesity, using PUMA deficient mice. At 10 weeks of age, knockout and wild type mice either continued consuming a low fat chow diet (6% fat), or were fed with a high fat diet (23% fat) for 14-17 weeks. We measured body composition, glucose and insulin tolerance, insulin response in peripheral tissues, energy expenditure, oxygen consumption, and respiratory exchange ratio in vivo. All these parameters were indistinguishable between wild type and knockout mice on chow diet and were modified equally by diet-induced obesity. Interestingly, we observed decreased food intake and ambulatory capacity of PUMA knockout mice on high fat diet. This was associated with increased adipocyte size and fasted leptin concentration in the blood. Our findings suggest that although PUMA is dispensable for glucose homeostasis in lean and obese mice, it can affect leptin levels and food intake during obesity.

  2. Pregnancy outcome and prepregnancy body mass index in 2459 glucose-tolerant Danish women

    DEFF Research Database (Denmark)

    Jensen, Dorte; Damm, Peter; Sørensen, Bente

    2003-01-01

    This study was undertaken to investigate the relationship between pregnancy outcome and prepregnancy overweight or obesity in women with a normal glucose tolerance test.......This study was undertaken to investigate the relationship between pregnancy outcome and prepregnancy overweight or obesity in women with a normal glucose tolerance test....

  3. Effect of Canagliflozin on Renal Threshold for Glucose, Glycemia, and Body Weight in Normal and Diabetic Animal Models

    Science.gov (United States)

    Liang, Yin; Arakawa, Kenji; Ueta, Kiichiro; Matsushita, Yasuaki; Kuriyama, Chiaki; Martin, Tonya; Du, Fuyong; Liu, Yi; Xu, June; Conway, Bruce; Conway, Jamie; Polidori, David; Ways, Kirk; Demarest, Keith

    2012-01-01

    Background Canagliflozin is a sodium glucose co-transporter (SGLT) 2 inhibitor in clinical development for the treatment of type 2 diabetes mellitus (T2DM). Methods 14C-alpha-methylglucoside uptake in Chinese hamster ovary-K cells expressing human, rat, or mouse SGLT2 or SGLT1; 3H-2-deoxy-d-glucose uptake in L6 myoblasts; and 2-electrode voltage clamp recording of oocytes expressing human SGLT3 were analyzed. Graded glucose infusions were performed to determine rate of urinary glucose excretion (UGE) at different blood glucose (BG) concentrations and the renal threshold for glucose excretion (RTG) in vehicle or canagliflozin-treated Zucker diabetic fatty (ZDF) rats. This study aimed to characterize the pharmacodynamic effects of canagliflozin in vitro and in preclinical models of T2DM and obesity. Results Treatment with canagliflozin 1 mg/kg lowered RTG from 415±12 mg/dl to 94±10 mg/dl in ZDF rats while maintaining a threshold relationship between BG and UGE with virtually no UGE observed when BG was below RTG. Canagliflozin dose-dependently decreased BG concentrations in db/db mice treated acutely. In ZDF rats treated for 4 weeks, canagliflozin decreased glycated hemoglobin (HbA1c) and improved measures of insulin secretion. In obese animal models, canagliflozin increased UGE and decreased BG, body weight gain, epididymal fat, liver weight, and the respiratory exchange ratio. Conclusions Canagliflozin lowered RTG and increased UGE, improved glycemic control and beta-cell function in rodent models of T2DM, and reduced body weight gain in rodent models of obesity. PMID:22355316

  4. Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models.

    Directory of Open Access Journals (Sweden)

    Yin Liang

    Full Text Available BACKGROUND: Canagliflozin is a sodium glucose co-transporter (SGLT 2 inhibitor in clinical development for the treatment of type 2 diabetes mellitus (T2DM. METHODS: (14C-alpha-methylglucoside uptake in Chinese hamster ovary-K cells expressing human, rat, or mouse SGLT2 or SGLT1; (3H-2-deoxy-d-glucose uptake in L6 myoblasts; and 2-electrode voltage clamp recording of oocytes expressing human SGLT3 were analyzed. Graded glucose infusions were performed to determine rate of urinary glucose excretion (UGE at different blood glucose (BG concentrations and the renal threshold for glucose excretion (RT(G in vehicle or canagliflozin-treated Zucker diabetic fatty (ZDF rats. This study aimed to characterize the pharmacodynamic effects of canagliflozin in vitro and in preclinical models of T2DM and obesity. RESULTS: Treatment with canagliflozin 1 mg/kg lowered RT(G from 415±12 mg/dl to 94±10 mg/dl in ZDF rats while maintaining a threshold relationship between BG and UGE with virtually no UGE observed when BG was below RT(G. Canagliflozin dose-dependently decreased BG concentrations in db/db mice treated acutely. In ZDF rats treated for 4 weeks, canagliflozin decreased glycated hemoglobin (HbA1c and improved measures of insulin secretion. In obese animal models, canagliflozin increased UGE and decreased BG, body weight gain, epididymal fat, liver weight, and the respiratory exchange ratio. CONCLUSIONS: Canagliflozin lowered RT(G and increased UGE, improved glycemic control and beta-cell function in rodent models of T2DM, and reduced body weight gain in rodent models of obesity.

  5. Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models.

    Science.gov (United States)

    Liang, Yin; Arakawa, Kenji; Ueta, Kiichiro; Matsushita, Yasuaki; Kuriyama, Chiaki; Martin, Tonya; Du, Fuyong; Liu, Yi; Xu, June; Conway, Bruce; Conway, Jamie; Polidori, David; Ways, Kirk; Demarest, Keith

    2012-01-01

    Canagliflozin is a sodium glucose co-transporter (SGLT) 2 inhibitor in clinical development for the treatment of type 2 diabetes mellitus (T2DM). (14)C-alpha-methylglucoside uptake in Chinese hamster ovary-K cells expressing human, rat, or mouse SGLT2 or SGLT1; (3)H-2-deoxy-d-glucose uptake in L6 myoblasts; and 2-electrode voltage clamp recording of oocytes expressing human SGLT3 were analyzed. Graded glucose infusions were performed to determine rate of urinary glucose excretion (UGE) at different blood glucose (BG) concentrations and the renal threshold for glucose excretion (RT(G)) in vehicle or canagliflozin-treated Zucker diabetic fatty (ZDF) rats. This study aimed to characterize the pharmacodynamic effects of canagliflozin in vitro and in preclinical models of T2DM and obesity. Treatment with canagliflozin 1 mg/kg lowered RT(G) from 415±12 mg/dl to 94±10 mg/dl in ZDF rats while maintaining a threshold relationship between BG and UGE with virtually no UGE observed when BG was below RT(G). Canagliflozin dose-dependently decreased BG concentrations in db/db mice treated acutely. In ZDF rats treated for 4 weeks, canagliflozin decreased glycated hemoglobin (HbA1c) and improved measures of insulin secretion. In obese animal models, canagliflozin increased UGE and decreased BG, body weight gain, epididymal fat, liver weight, and the respiratory exchange ratio. Canagliflozin lowered RT(G) and increased UGE, improved glycemic control and beta-cell function in rodent models of T2DM, and reduced body weight gain in rodent models of obesity.

  6. Body composition and somatotype of the elite of Polish fencers.

    Science.gov (United States)

    Sterkowicz-Przybycień, Katarzyna

    2009-09-01

    The purpose of this study was to determine body composition and somatotype of the male fencers who were grouped by different fencing weapons. Analysis of body composition, with untrained men as background, will update the data necessary for the somatic profiles of fencers. Thirty contestants were examined during the Polish Fencing Championships in 2004. They took part in epée (n = 10), foil (n = 10) and sabre (n = 10). They were aged 23.3 +/- 2.9; their length of training was 12.6 +/- 2.5 years, with the frequency of training 15.9 +/- 3.1 hours per week. In each weapon style there were champions and vice-champions of Poland from the year 2004. Twelve of them were classified among the first fifty contestants according to the D'Escrime International Federation (FIE) ranking. An experienced evaluator performed 10 measurements necessary to designate somatotypes by means of Heath-Carter method and to estimate the percentage of body fat and composition. Sabre fencers (weight = 84.4 kg, somatotype = 3.4-5.4-1.8) were heavier than both epée fencers (77.9 kg, 3.6-4.9-2.5) and foil fencers (74.9 kg, 2.9-4.2-2.8). Sabre specialists had higher mesomorphy than foil fencers (ANOVA and Bonferroni's multi comparison test). Sabre fencers were characterized by higher fat free mass and a higher BMI and fat free mass index than fencers of the other two weapons. Discriminant analysis result was significant (p somatotypes differed from the somatotypes of the untrained (3.3-4.8-2.3 vs. 3.7-4.3-3.1). They were characterized by their higher mesomorphy (t = 2.10, p < 0.05) and lower ectomorphy (t = 3.48, p < 0.01), as well as greater adiposity (16.8 vs. 15.7%, t = 2.03, p < 0.05).

  7. Growth and Body Composition of School-Aged Children

    DEFF Research Database (Denmark)

    Dalskov, Stine-Mathilde

    based on the NND increased WC, AFM:TFM in intention-to-treat analyses and in completers-analysis also FMI compared with control in 8-11-yearold children, while no effects were seen on height, BMI z-score and FFMI. Effects were not dependent of initial BMI, and adjustment for physical activity, pubertal...... of contemporary Danish children. We did find the “classical” height velocity peak during spring, but unlike many earlier studies this was coincident with peaks in BW, BMI and FFMI velocities. Seasonal variation in physical activity may explain seasonal variations in BW and body composition velocities. Taken...... on energy metabolism and body fat deposition. The other way around overweight children seem to have an up-regulation of linear growth prior to puberty and a larger bone mass than their leaner peers, which may be partly due to the influence of adipokines or other hormones related to energy metabolism on bone...

  8. Longitudinal body composition of children born to normal weight, overweight and obese mothers

    Science.gov (United States)

    Objective: The longitudinal trajectories of body composition of children born to normal weight, overweight and obese mothers have not been evaluated using precise body composition methods. This study investigated the relationship between maternal pre-pregnancy BMI and offspring body composition traj...

  9. Body size, body composition, and cardiovascular disease risk factors in NFL players.

    Science.gov (United States)

    Allen, Thomas W; Vogel, Robert A; Lincoln, Andrew E; Dunn, Reginald E; Tucker, Andrew M

    2010-04-01

    We characterized the size of active National Football League (NFL) players by multiple criteria and analyzed their relation to traditional cardiovascular disease (CVD) risk factors with the objective of further clarifying the occurrence of cardiovascular risk factors in different player positions. This cross-sectional study was conducted in professional athletic training facilities. The participants were 504 active veteran players from a convenience sample of 12 NFL teams, grouped as interior linemen (IL) or all others (AO). Comparisons were made between the NFL groups and an age-equivalent general population database. The IL group was significantly larger than AO by all size measures. Both groups were significantly larger than the Coronary Artery Risk Development in Young Adults (CARDIA) group. Mean percent body fat measurements in AO (mean, 13.4%; 95% confidence interval [CI], 12.9%-14%) and IL (mean, 25.2%; 95% CI, 24.4%-26%) groups were lower than estimates for the general population. Systolic blood pressure (BP) was higher in IL (mean, 131 mm Hg; 95% CI, 129-133 mm Hg) than AO (mean, 126 mm Hg; 95% CI, 125-127 mm Hg) and greater in both groups compared with the CARDIA group (mean, 112 mm Hg; 95% CI, 111-112 mm Hg). Mean low-density lipoprotein cholesterol and high-density lipoprotein cholesterol (HDL-C), total cholesterol, triglycerides, and glucose were within the normal range for both IL and AO. Interior linemen had significantly lower HDL-C than AO and the CARDIA group. Both NFL groups had significantly lower fasting glucose than CARDIA. Body fat in active NFL players was lower than predicted by standard measures of obesity. Although the players were large, they were in the normal range for most CVD risk factors. Mean BP in the prehypertensive range was found in both NFL position groups, but was significantly higher in IL than in AO. Prehypertension in these athletes warrants vigilance.

  10. Improved glucose control and reduced body weight in rodents with dual mechanism of action peptide hybrids.

    Directory of Open Access Journals (Sweden)

    James L Trevaskis

    Full Text Available Combination therapy is being increasingly used as a treatment paradigm for metabolic diseases such as diabetes and obesity. In the peptide therapeutics realm, recent work has highlighted the therapeutic potential of chimeric peptides that act on two distinct receptors, thereby harnessing parallel complementary mechanisms to induce additive or synergistic benefit compared to monotherapy. Here, we extend this hypothesis by linking a known anti-diabetic peptide with an anti-obesity peptide into a novel peptide hybrid, which we termed a phybrid. We report on the synthesis and biological activity of two such phybrids (AC164204 and AC164209, comprised of a glucagon-like peptide-1 receptor (GLP1-R agonist, and exenatide analog, AC3082, covalently linked to a second generation amylin analog, davalintide. Both molecules acted as full agonists at their cognate receptors in vitro, albeit with reduced potency at the calcitonin receptor indicating slightly perturbed amylin agonism. In obese diabetic Lep(ob/Lep (ob mice sustained infusion of AC164204 and AC164209 reduced glucose and glycated haemoglobin (HbA1c equivalently but induced greater weight loss relative to exenatide administration alone. Weight loss was similar to that induced by combined administration of exenatide and davalintide. In diet-induced obese rats, both phybrids dose-dependently reduced food intake and body weight to a greater extent than exenatide or davalintide alone, and equal to co-infusion of exenatide and davalintide. Phybrid-mediated and exenatide + davalintide-mediated weight loss was associated with reduced adiposity and preservation of lean mass. These data are the first to provide in vivo proof-of-concept for multi-pathway targeting in metabolic disease via a peptide hybrid, demonstrating that this approach is as effective as co-administration of individual peptides.

  11. Body Composition in Adult Patients with Thalassemia Major

    Directory of Open Access Journals (Sweden)

    Marianna Vlychou

    2016-01-01

    Full Text Available Objective. To assess body composition in adult male and female patients with thalassemia major by dual-energy X-ray absorptiometry (DXA and to compare the findings with a group of healthy age-matched controls. Methods. Our study group included sixty-two patients (27 males, mean age 36 years, and 35 females, mean age 36.4 years and fifteen age-matched healthy controls. All patients had an established diagnosis of thalassemia major and followed a regular blood transfusion scheme since childhood and chelation treatment. Fat, lean, and bone mineral density (BMD were assessed with dual-energy X-ray absorptiometry. Ferritin levels and body mass index of all patients and controls were also recorded. Student t-test and Wilcoxon test were performed and statistical significance was set at p<0.05. Results. BMD and whole body lean mass are lower in both male and female adult patients compared with controls (p<0.01 in both groups, whereas whole body fat mass was found to have no statistically significant difference compared to controls. Regional trunk fat around the abdomen was found to be lower in male patients compared to controls (p=0.02. Conclusion. Severe bone loss and diminished lean mass are expected in adult male and female patients with thalassemia major. Fat changes seem to affect mainly male patients.

  12. Dietary intake and body composition of prepubescent female aesthetic athletes.

    Science.gov (United States)

    Soric, Maroje; Misigoj-Durakovic, Marjeta; Pedisic, Zeljko

    2008-06-01

    The purpose of this study was to assess dietary intake and body composition of prepubescent girls competing in 3 aesthetic sports (artistic and rhythmic gymnastics and ballet). Because physiological demands of ballet training are similar to those in other aesthetic sports, ballet dancers were, for the purpose of this study, regarded as athletes. The sample consisted of 39 athletes (median age, 11 years, range 9-13) and 15 controls (median age, 11 years, range 10-12). Dietary intake was assessed using a quantitative food frequency questionnaire, and body composition, by means of anthropometry. There was no significant difference in total energy intake between groups, but there was a significant difference in energy substrate distribution. Artistic gymnasts reported significantly higher carbohydrate and lower fat contribution to total energy (57% +/- 6% and 29% +/- 5%, respectively) than rhythmic gymnasts (48% +/- 6% and 36% +/- 5%), ballet dancers (51% +/- 4% and 34% +/- 3%), or controls (51% +/- 5% and 34% +/- 4%). Relative to body weight, artistic gymnasts reported higher intake of carbohydrates (9.1 +/- 4.2 g/kg) than rhythmic gymnasts (5.6 +/- 3.1 g/kg), ballet dancers (6.6 +/- 2.5 g/kg), or controls (5.4 +/- 1.9 g/kg). Artistic gymnasts also had the lowest body-fat percentage among the groups. In all the groups mean reported daily intakes of most nutrients were higher than the current daily recommended intakes. The exceptions were dietary fiber and calcium. The proportion of athletes with an inadequate reported intake was highest for phosphorus (33%), followed by vitamin A and niacin (18%) and zinc (13%).

  13. The Effects of Different Exercise Programmes on Female Body Composition

    Directory of Open Access Journals (Sweden)

    Soares Costa de Mendonça Rosa Maria

    2014-12-01

    Full Text Available The purpose of this study was to verify the effects of 16 weeks of practicing different exercise programmes on body composition. This is an exploratory and descriptive study of 89 women aged 25 to 55 years (41.42 ± 9.23 years. The subjects were randomly divided into three experimental groups (EG: practitioners of strength training (SG, dance (DG, hydrogymnastics (HG, and a control group (CG with sedentary women. Measurements of body mass and height, circumferences of the chest, waist, abdomen, hips, thighs, calves, and skinfolds of the triceps, suprailiac and thigh were registered in three different moments: prior to the commencement of the training program, again after 8 weeks of training, and finally after 16 weeks of training. Body density was estimated by using the trifold protocol by Jackson, Pollock and Ward. The ANOVA and deltas of change (Δ% were used for data analysis. The level of significance was set at p<0.05. The effects of greater statistical significance on body composition related the variables "time", "group" and the interaction between the two (time x group were observed for the percentage of fat - F% (F (1.79, 152.52 = 24.59, p <0.001, η 2 = 0.22, fat mass - FM (F (1.75, 149.01 = 12.65, p <0.001, η 2 = 0.13 and lean mass - LM (F (1.77, 150.66 = 47.38, p <0.001, η 2 = 0.36. The HG and SG were more beneficial in reducing F%. It was observed that the EG indicated healthier anthropometric aspects compared to the CG, regardless of the type of exercise programmes practiced. The time factor was more representative over the effects of exercise on anthropometric dimensions.

  14. Central sensibility of human cases with different body mass during oral glucose tolerance test using functional magnetic resonance imaging

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    BACKGROUND: Because of the limitation of technique, there are few researches on regulating function of central hypothalamus by metabolism, especially the researches on real-time function.OBJECTIVE: To evaluate the response of hypothalamus to oral glucose tolerance test (OGTT) in different body-weighted subjects by using functional magnetic resonance imaging (fMRI) so as to investigate the relationship between the sensitivity of hypothalamus in glycoregulation and disturbance of carbohydrate metabolism.DESIGN: Paired design.SETTING: Department of Radiology and Beijing Geriatrics Institute, Beijing Hospital, National Public Health Bureau.PARTICIPANTS: A total of twenty healthy volunteers were selected from Beijing Geriatrics Institute,National Public Health Bureau, including 10 subjects with obesity (5 males and 5 females; body mass >28.0 kg/m2) and 10 subjects with normal body mass (5 males and 5 females; body mass from 18.5 to 23.9 kg/m2). All subjects gave written informed consent before participating in the study.METHODS: fMRI study was performed on GE 1.5 T Signa Twinspeed Infinity with Excite. Each volunteer was ingested of glucose during the fMRI scan. T2* images were acquired using a single-shot gradient echo (EPI) technique. The parameters of EPI included: TR 3 000 ms, TE 40 ms, Flip angle 90 ° , field of view (FOV) 24 cm × 24 cm, thickness 5 mm, gap 0 mm, matrix 64 × 64, number of excitation 1. All 10 subjects with normal body mass underwent a repeat fMRI scan after consuming an equivalent amount of water without glucose on a separate day. The procedure for the fMRI scan with water intake was the same as for glucose ingestion. fMRI data were processed with Intensity Averaging Method.MAIN OUTCOME MEASURES: The central response of hypothalamus and feedback orientation during OGTT in different body-weighted subjects.RESULTS: An acute transient decrease of fMRI intensity in posterior inferior and anterior inferior of hypothalamus was observed in all

  15. Association between body composition and body mass index in young Japanese women.

    Science.gov (United States)

    Yamagishi, Hiroyuki; Kitano, Takao; Kuchiki, Tsutomu; Okazaki, Hideki; Shibata, Shigeo

    2002-06-01

    The National Nutrition Survey of Japan indicated a trend toward a decreasing body mass index (BMI; kg/m2) among young Japanese women. Current studies suggest that not-high BMI often does not correlate with not-high body fat percentage. Recently, the classification of BMI in adult Asians was proposed by the International Obesity Task Force. The addition of an "at risk of overweight" category, BMI as 23.0-24.9, was intended to prevent chronic diseases. We investigated the association between body fat percentage (BF%) and BMI to evaluate the screening performance of BMI focused on individual preventive medicine. The subjects consisted of 605 female college students. The subjects' ages (y), heights (cm), body weights (kg), BMIs, and BF percents with underwater weighing expressed as the means +/- SD were 19.6 +/- 0.5, 158.7 +/- 5.6, 53.8 +/- 7.2, 21.3 +/- 2.4, and 24.9 +/- 4.9, respectively. We defined high BF% as +/- 85th percentile of BF% (29.8%). High-BF% individuals are often not classified into BMI > or = 23.0 because their BMI readings are very broad (18.4-31.7). In comparison to the screening performances (specificity and sensitivity), BMI > or = 23.0 (85.3% and 52.1%, respectively), rather than BMI > or = 25.0 (96.7% and 29.8%, respectively), is recommended for the mass evaluation of fatness. For this reason, the BMI "at risk of overweight" category is characterized as the threshold of increasing the appearance ratio of high-BF% individuals. In conclusion, the BMI > or = 25.0 kg/m2 category is determined as high BF%, regardless of body composition measurement for mass evaluation as a result of quite high specificity. Even so, body composition measurement is necessitated by the individual evaluation of fatness focused on preventive medicine because BMI performed a poor representation of body composition, especially BMI < 25.0 kg/m2 individuals.

  16. Validation of Body Condition Indices and Quantitative Magnetic Resonance in Estimating Body Composition in a Small Lizard

    Science.gov (United States)

    WARNER, DANIEL A.; JOHNSON, MARIA S.; NAGY, TIM R.

    2017-01-01

    Measurements of body condition are typically used to assess an individual’s quality, health, or energetic state. Most indices of body condition are based on linear relationships between body length and mass. Although these indices are simple to obtain, nonlethal, and useful indications of energetic state, their accuracy at predicting constituents of body condition (e.g., fat and lean mass) are often unknown. The objectives of this research were to (1) validate the accuracy of another simple and noninvasive method, quantitative magnetic resonance (QMR), at estimating body composition in a small-bodied lizard, Anolis sagrei, and (2) evaluate the accuracy of two indices of body condition (based on length–mass relationships) at predicting body fat, lean, and water mass. Comparisons of results from QMR scans to those from chemical carcass analysis reveal that QMR measures body fat, lean, and water mass with excellent accuracy in male and female lizards. With minor calibration from regression equations, QMR will be a reliable method of estimating body composition of A. sagrei. Body condition indices were positively related to absolute estimates of each constituent of body composition, but these relationships showed considerable variation around regression lines. In addition, condition indices did not predict fat, lean, or water mass when adjusted for body mass. Thus, our results emphasize the need for caution when interpreting body condition based upon linear measurements of animals. Overall, QMR provides an alternative noninvasive method for accurately measuring fat, lean, and water mass in these small-bodied animals. PMID:28035770

  17. New techniques in nutritional assessment: body composition methods.

    Science.gov (United States)

    Elia, M; Ward, L C

    1999-02-01

    New techniques in air-displacement plethysmography seem to have overcome many of the previous problems of poor reproducibility and validity. These have made body-density measurements available to a larger range of individuals, including children, elderly and sick patients who often have difficulties in being submerged underwater in hydrodensitometry systems. The BOD POD air-displacement system (BOD POD body composition system; Life Measurement Instruments, Concord, CA, USA) is more precise than hydrodensitometry, is simple and rapid to operate (approximately 1 min measurements) and the results agree closely with those of hydrodensitometry (e.g. +/- 3.4% for estimation of body fat). Body line scanners employing the principles of three-dimensional photography are potentially able to measure the surface area and volume of the body and its segments even more rapidly (approximately 10 s), but the validity of the measurements needs to be established. Advances in i.r. spectroscopy and mathematical modelling for calculating the area under the curve have improved precision for measuring enrichment of 2H2O in studies of water dilution (CV 0.1-0.9% within the range of 400-1000 microliters/l) in saliva, plasma and urine. The technique is rapid and compares closely with mass spectrometry (bias 1 (SD 2) %). Advances in bedside bioelectrical-impedance techniques are making possible potential measurements of skinfold thicknesses and limb muscle mass electronically. Preliminary results suggest that the electronic method is more reproducible (intra- and inter-individual reproducibility for measuring skinfold thicknesses) and associated with less bias (+12%), than anthropometry (+40%). In addition to these selected examples, the 'mobility' or transfer of reference methods between centres has made the distinction between reference and bedside or field techniques less distinct than in the past.

  18. Insulin Dynamics in Young Women with Polycystic Ovary Syndrome and Normal Glucose Tolerance across Categories of Body Mass Index

    Science.gov (United States)

    Manco, Melania; Castagneto-Gissey, Lidia; Arrighi, Eugenio; Carnicelli, Annamaria; Brufani, Claudia; Luciano, Rosa; Mingrone, Geltrude

    2014-01-01

    Background Evidence favours insulin resistance and compensatory hyperinsulinemia as the predominant, perhaps primary, defects in polycystic ovary syndrome (PCOS). The aim of the present study was to evaluate insulin metabolism in young women with PCOS but normal glucose tolerance as compared with age, body mass index and insulin resistance-matched controls to answer the question whether women with PCOS hypersecrete insulin in comparison to appropriately insulin resistance-matched controls. Research Design and Methods Sixty-nine cases were divided according to their body mass index (BMI) in normal-weight (N = 29), overweight (N = 24) and obese patients (N = 16). Controls were 479 healthy women (age 16–49 y). Whole body Insulin Sensitivity (WBISI), fasting, and total insulin secretion were estimated following an oral glucose tolerance test (C-peptide deconvolution method). Results Across classes of BMI, PCOS patients had greater insulin resistance than matched controls (p<0.0001 for all the comparisons), but they showed higher fasting and total insulin secretion than their age, BMI and insulin resistance-matched peers (p<0.0001 for all the comparisons). Conclusion Women with PCOS show higher insulin resistance but also larger insulin secretion to maintain normal glucose homeostasis than age-, BMI- and insulin resistance-matched controls. PMID:24705280

  19. Insulin dynamics in young women with polycystic ovary syndrome and normal glucose tolerance across categories of body mass index.

    Directory of Open Access Journals (Sweden)

    Melania Manco

    Full Text Available BACKGROUND: Evidence favours insulin resistance and compensatory hyperinsulinemia as the predominant, perhaps primary, defects in polycystic ovary syndrome (PCOS. The aim of the present study was to evaluate insulin metabolism in young women with PCOS but normal glucose tolerance as compared with age, body mass index and insulin resistance-matched controls to answer the question whether women with PCOS hypersecrete insulin in comparison to appropriately insulin resistance-matched controls. RESEARCH DESIGN AND METHODS: Sixty-nine cases were divided according to their body mass index (BMI in normal-weight (N = 29, overweight (N = 24 and obese patients (N = 16. Controls were 479 healthy women (age 16-49 y. Whole body Insulin Sensitivity (WBISI, fasting, and total insulin secretion were estimated following an oral glucose tolerance test (C-peptide deconvolution method. RESULTS: Across classes of BMI, PCOS patients had greater insulin resistance than matched controls (p<0.0001 for all the comparisons, but they showed higher fasting and total insulin secretion than their age, BMI and insulin resistance-matched peers (p<0.0001 for all the comparisons. CONCLUSION: Women with PCOS show higher insulin resistance but also larger insulin secretion to maintain normal glucose homeostasis than age-, BMI- and insulin resistance-matched controls.

  20. Physical activity, body composition and metabolic syndrome in young adults.

    Directory of Open Access Journals (Sweden)

    Minna K Salonen

    Full Text Available Low physical activity (PA is a major risk factor for cardiovascular and metabolic disorders in all age groups. We measured intensity and volume of PA and examined the associations between PA and the metabolic syndrome (MS, its components and body composition among young Finnish adults.The study comprises 991 men and women born 1985-86, who participated in a clinical study during the years 2009-11 which included assessments of metabolism, body composition and PA. Objectively measured (SenseWear Armband five-day PA data was available from 737 participants and was expressed in metabolic equivalents of task (MET.The prevalence of MS ranged between 8-10%. Higher total mean volume (MET-hours or intensity (MET were negatively associated with the risk of MS and separate components of MS, while the time spent at sedentary level of PA was positively associated with MS.MS was prevalent in approximately every tenth of the young adults at the age of 24 years. Higher total mean intensity and volume rates as well as longer duration spent at moderate and vigorous PA level had a beneficial impact on the risk of MS. Longer time spent at the sedentary level of PA increased the risk of MS.

  1. Transgenic Rescue of Adipocyte Glucose-dependent Insulinotropic Polypeptide Receptor Expression Restores High Fat Diet-induced Body Weight Gain

    DEFF Research Database (Denmark)

    Ugleholdt, Randi; Pedersen, Jens; Bassi, Maria Rosaria

    2011-01-01

    to adipose tissue have a similar high fat diet -induced body weight gain as control mice, significantly greater than the weight gain in mice with a general ablation of the receptor. Surprisingly, this difference was due to an increase in total lean body mass rather than a gain in total fat mass......The glucose-dependent insulinotropic polypeptide receptor (GIPr) has been implicated in high fat diet-induced obesity and is proposed as an anti-obesity target despite an uncertainty regarding the mechanism of action. To independently investigate the contribution of the insulinotropic effects...

  2. Alterations of body mass index and body composition in atomic bomb survivors.

    Science.gov (United States)

    Tatsukawa, Y; Misumi, M; Yamada, M; Masunari, N; Oyama, H; Nakanishi, S; Fukunaga, M; Fujiwara, S

    2013-08-01

    Obesity, underweight, sarcopenia and excess accumulation of abdominal fat are associated with a risk of death and adverse health outcomes. Our aim was to determine whether body mass index (BMI) and body composition, assessed with dual-energy X-ray absorptiometry (DXA), are associated with radiation exposure among atomic bomb (A-bomb) survivors. This was a cross-sectional study conducted in the Adult Health Study of the Radiation Effects Research Foundation. We examined 2686 subjects (834 men and 1852 women), aged 48-89 years (0-40 years at A-bomb exposure), for BMI analysis. Among them, 550 men and 1179 women underwent DXA in 1994-1996 and were eligible for a body composition study. After being adjusted for age and other potential confounding factors, A-bomb radiation dose was associated significantly and negatively with BMI in both sexes (P=0.01 in men, P=0.03 in women) and appendicular lean mass (Pbomb radiation exposure. We will need to conduct further studies to evaluate whether these alterations affect health status.

  3. [Body composition at menarche. Estimation of total body weight, total body water, lean and fat body weight].

    Science.gov (United States)

    Zurlo de Mirotti, S M; Lesa, A M; Barrón de Carbonetti, M; Roitter, H; Villagra de Lacuara, S

    1995-01-01

    Our aim was to confirm in our environment what has been observed and described by other writers about the importance of achieving a "critical body weight'' and an adequate "fat percentage'' -on the basis of the calculation of total body water- for the initiation and development of pubertal events. This study included 92 girls, healthy, well nourished, belonging to upper middle class from a high school of The National University of Cordoba. The longitudinal method of control was used every 6 months and at the precise moment of menarche. Out of 20 antropometrical variables observed height, weight and height, TBW as percentage of body weight, lean body and fat weight, fat percentage and skin folds ppercentiles for each girl at menarche. A regression between fat percentage and skin folds was done. Percentiles 5 to 95 of fat percentage in relation to body water percentage were estimated. At menarche the average for the different variables are: Heigth 155.6 cm +/- 0.469; Weight 45.8 Kg +/- 0,5; TBW 25.216 lit. +/- 0.318; lean body weigth 35.02 Kg (S.D.2.98); fat weigth 10.86 Kg (S. D. 3.17). The addition of skin folds was correlated fat percentage, thus, an equation was obtained for the average calculation of such percentage %F= 12.16 + (0.313 x fold addition). The minium percentage for the onset of menstrual cycles is 17.3% and corresponds to percentile 10. However, there is a 5% of girls who start to menstruate with a 15.5% of fat and none of them is below that value. The reasons mentioned above suggest that is necessary to obtain a "critical body weigth'' as well as a "fat percentage'' minimum for the onset and maintenance of menstrual cycles, among our girls, similar o what has been obtained by doctor Frisch.

  4. The influence of maternal body composition on birth weight.

    LENUS (Irish Health Repository)

    Farah, Nadine

    2012-02-01

    OBJECTIVE: To identify the maternal body composition parameters that independently influence birth weight. STUDY DESIGN: A longitudinal prospective observational study in a large university teaching hospital. One hundred and eighty-four non-diabetic caucasian women with a singleton pregnancy were studied. In early pregnancy maternal weight and height were measured digitally in a standardised way and the body mass index (BMI) was calculated. At 28 and 37 weeks\\' gestation maternal body composition was assessed using segmental multifrequency bioelectrical impedance analysis. At delivery the baby was weighed and the clinical details were recorded. RESULTS: Of the women studied, 29.2% were overweight and 34.8% were obese. Birth weight did not correlate with maternal weight or BMI in early pregnancy. Birth weight correlated with gestational weight gain (GWG) before the third trimester (r=0.163, p=0.027), but not with GWG in the third trimester. Birth weight correlated with maternal fat-free mass, and not fat mass at 28 and 37 weeks gestation. Birth weight did not correlate with increases in maternal fat and fat-free masses between 28 and 37 weeks. CONCLUSIONS: Contrary to previous reports, we found that early pregnancy maternal BMI in a non-diabetic population does not influence birth weight. Interestingly, it was the GWG before the third trimester and not the GWG in the third trimester that influenced birth weight. Our findings have implications for the design of future intervention studies aimed at optimising gestational weight gain and birth weight. CONDENSATION: Maternal fat-free mass and gestational weight gain both influence birth weight.

  5. Body composition and lipodystrophy in prepubertal HIV-infected children

    Directory of Open Access Journals (Sweden)

    Cecilia Zanin Palchetti

    2013-02-01

    Full Text Available OBJECTIVE: To identify lipodystrophy in prepubertal HIV-infected children using anthropometric parameters and body composition assessment. METHODS: Cross-sectional study including 40 prepubertal HIV-infected children of both genders seen at the Care Center of the Division of Pediatric Infectious Diseases - Universidade Federal de São Paulo, São Paulo city, Brazil, was carried out from August to December 2008. Age, clinical and immunological status, prophylaxis, transmission and highly active antiretroviral therapy were recorded. Body mass index z-score and height-for-age z-score were calculated to characterize the nutritional status. Circumferences were measured with flexible tape and skinfolds were assessed by an adipometry. Fat mass and lean mass were determined by dual-energy X-ray absorptiometry. Presence of clinical signs of lipodystrophy was assessed by a trained clinician. Data were analyzed using SPSS 12.0 software. RESULTS: The mean age and standard deviation were 9.8 (1.2 years, 50% were girls and 82.5% children from B and C categories. Clinical lipodystrophy and dislypidemia were present in 27.5% and 70%, respectively. The trunk to arm ratio and the limb to trunk ratio had positive association with lipodystrophy. Patients with lipodystrophy had short stature, higher triglycerides values and lower HDL-cholesterol. CONCLUSION: The ratios obtained by skinfolds and dual-energy X-ray absorptiometry measurements can be considered as indicators of preclinical lipodystrophy. The cutoff points have not been determined yet; however, continuous assessment may be useful to identify early body composition changes.

  6. Impact of body-composition methodology on the composition of weight loss and weight gain.

    Science.gov (United States)

    Pourhassan, M; Schautz, B; Braun, W; Gluer, C-C; Bosy-Westphal, A; Müller, M J

    2013-05-01

    We intended to (i) to compare the composition of weight loss and weight gain using densitometry, deuterium dilution (D₂O), dual-energy X-ray absorptiometry (DXA), magnetic resonance imaging (MRI) and the four-compartment (4C) model and (ii) to compare regional changes in fat mass (FM), fat-free mass (FFM) and skeletal muscle as assessed by DXA and MRI. Eighty-three study participants aged between 21 and 58 years with a body mass index range of 20.2-46.8 kg/m(2) had been assessed at two different occasions with a mean follow-up between 23.5 and 43.5 months. Body-weight changes within weight stable, a gain or a loss of >3% of initial weight was considered as a significant weight change. There was a considerable bias between the body-composition data obtained by the individual methods. When compared with the 4C model, mean bias of D₂O and densitometry was explained by the erroneous assumption of a constant hydration of FFM, thus, changes in FM were underestimated by D₂O but overestimated by densitometry. Because hydration does not normalize after weight loss, all two-component models have a systematic error in weight-reduced subjects. The bias between 4C model and DXA was mainly explained by FM% at baseline, whereas FFM hydration contributed to additional 5%. As to the regional changes in body composition, DXA data had a considerable bias and, thus, cannot replace MRI. To assess changes in body composition associated with weight changes, only the 4C model and MRI can be used with confidence.

  7. Effect of infant feeding on maternal body composition

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    McDougald Dawn M

    2008-08-01

    Full Text Available Abstract Background Women gain total body weight and accrue body fat during pregnancy. Breastfeeding has been suggested as an efficient means of promoting postpartum weight loss due to its high energy cost. We investigated the effect of infant feeding mode on maternal body composition. Methods This study evaluated maternal weight and percent body fat changes in exclusively breastfeeding versus mixed feeding mothers during the first 12 weeks postpartum using the BOD POD. Twenty four mothers aged 19 – 42 years were studied. Participants were recruited from Athens-Clarke County and surrounding areas of the State of Georgia, USA. The study was conducted between November 2005 and December 2006. Results Prepregnancy weight was higher in mixed feeding mothers than in exclusively breastfeeding mothers (68.4 kg vs. 61.4 kg but the difference was not statistically significant. At 12 weeks postpartum, exclusively breastfeeding mothers had lost more total body weight than mixed feeding mothers (4.41 ± 4.10 kg versus 2.79 ± 3.09 kg; p = 0.072. There was no significant difference in fat weight change between the two groups (4.38 ± 2.06 kg versus 4.17 ± 2.63 kg. However, mixed feeding mothers lost slightly more percent body fat than exclusively breastfeeding mothers (1.90 ± 4.18 kg versus 1.71 ± 3.48 kg, but the difference was not statistically significant. The trend in percent body fat loss was significant among exclusively breastfeeding mothers (p = 0.034 but not mixed feeding mothers (p = 0.081. Exclusively breastfeeding mothers consumed more calories than mixed feeding mothers (1980 ± 618 kcal versus 1541 ± 196 kcal p = 0.08. Physical activity levels were, however, higher in mixed feeding mothers than exclusively breastfeeding mothers. Conclusion Our results provide further evidence that exclusive breastfeeding promotes greater weight loss than mixed feeding among mothers even in the early postpartum period. This suggests that there is the need

  8. Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy.

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    Hvid, Thine; Winding, Kamilla; Rinnov, Anders; Dejgaard, Thomas; Thomsen, Carsten; Iversen, Peter; Brasso, Klaus; Mikines, Kari J; van Hall, Gerrit; Lindegaard, Birgitte; Solomon, Thomas P J; Pedersen, Bente K

    2013-10-01

    Insulin resistance and changes in body composition are side effects of androgen deprivation therapy (ADT) given to prostate cancer patients. The present study investigated whether endurance training improves insulin sensitivity and body composition in ADT-treated prostate cancer patients. Nine men undergoing ADT for prostate cancer and ten healthy men with normal testosterone levels underwent 12 weeks of endurance training. Primary endpoints were insulin sensitivity (euglycemic-hyperinsulinemic clamps with concomitant glucose-tracer infusion) and body composition (dual-energy X-ray absorptiometry and magnetic resonance imaging). The secondary endpoint was systemic inflammation. Statistical analysis was carried out using two-way ANOVA. Endurance training increased VO2max (ml(O2)/min per kg) by 11 and 13% in the patients and controls respectively (Phepatic insulin sensitivity (P=0.32). Muscle protein content of GLUT4 (SLC2A4) and total AKT (AKT1) was also increased in response to the training (Pfat mass (FM) (Pvisceral (Pcancer patients exhibited improved insulin sensitivity and body composition to a similar degree as eugonadal men.

  9. Relationship between body composition and blood pressure in Bahraini adolescents.

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    Al-Sendi, Aneesa M; Shetty, Prakash; Musaiger, Abdulrahman O; Myatt, Mark

    2003-10-01

    The objective of the present study was to examine the relationship between body composition and blood pressure (BP) in Bahraini adolescents. A sample of 504 Bahraini schoolchildren aged 12-17 years (249 boys and 255 girls) was selected using a multi-stage stratified sampling procedure. BP measurements were performed on the students. Anthropometric data including weight, height, waist circumference (WC), hip circumference, and triceps, subscapular and medial calf skinfold thicknesses were also collected. BMI, percentage body fat, waist:hip (WHR), and subscapular:triceps skinfold ratio were calculated. Mean systolic BP and mean diastolic BP were higher in males than in females. Weight and height in boys and weight only in girls were significantly associated with systolic BP independent of age or percentage fat. Nearly 14 % of the adolescents were classified as having high BP. BMI and percentage body fat were significantly and positively associated with the risk of having high BP in the boys and girls. Adolescents with high WHR or WC, as indicators for central obesity, tended to have higher BP values. The results from the present study indicate that obesity influences the BP of Bahraini adolescents and that simple anthropometric measurements such as WHR and WC are useful in identifying children at risk of developing high BP. These findings together with the known tracking of BP from adolescence into adulthood underline the importance of establishing intervention programmes in order to prevent the development of childhood and adolescent obesity.

  10. Growth and body composition in Brazilian female rhythmic gymnastics athletes.

    Science.gov (United States)

    Camargo, Cristiane Teixeira Amaral; Gomez-Campos, Rossana Anelice; Cossio-Bolaños, Marco Antonio; Barbeta, Vinicius Justino De Oliveira; Arruda, Miguel; Guerra-Junior, Gil

    2014-01-01

    The aim was to analyse the physical growth and body composition of rhythmic gymnastics athletes relative to their level of somatic maturation. This was a cross-sectional study of 136 athletes on 23 teams from Brazil. Mass, standing height and sitting height were measured. Fat-free and fat masses, body fat percentages and ages of the predicted peak height velocity (PHV) were calculated. The z scores for mass were negative during all ages according to both WHO and Brazilian references, and that for standing height were also negative for all ages according to WHO reference but only until 12 years old according to Brazilian reference. The mean age of the predicted PHV was 12.1 years. The mean mass, standing and sitting heights, body fat percentage, fat-free mass and fat mass increased significantly until 4 to 5 years after the age of the PHV. Menarche was reached in only 26% of these athletes and mean age was 13.2 years. The mass was below the national reference standards, and the standing height was below only for the international reference, but they also had late recovery of mass and standing height during puberty. In conclusion, these athletes had a potential to gain mass and standing height several years after PHV, indicating late maturation.

  11. Body composition and pulmonary function in Cystic Fibrosis

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    Saba eSheikh

    2014-04-01

    Full Text Available Background: Lower body mass index (BMI is associated with worse pulmonary function in cystic fibrosis (CF. Hypothesis: Lean body mass (LBM is more strongly associated with pulmonary function than BMI is.Methods: Anthropometrics, body composition by dual x-ray absorptiometry, and pulmonary function were determined in pancreatic insufficient CF (PI-CF youth. Sex and age-adjusted Z-scores (BMI-Z, LBMI-Z, FMI-Z were generated for CF and controls. 1 Associations of BMI-Z with LBMI-Z and FMI-Z and 2 age-adjusted associations of BMI-Z, LBMI-Z, and FMI-Z with FEV1%-predicted were tested. Results: 208 PI-CF subjects had lower BMI-Z, LBMI-Z, FMI-Z compared to 390 controls. BMI-Z was associated with lower LBMI-Z (pConclusions: In PI-CF youth, deficits in LBM were apparent. At lower BMI percentiles, BMI may not accurately depict LBM in PI-CF. In under-nourished PI-CF youth this preservation of FM in preference to LBM is relevant since LBMI-Z, but not FMI-Z, is positively associated with FEV1%-predicted. LBMI is more strongly associated with lung function compared to BMI, especially in the undernourished child and adolescent with PI-CF.

  12. Body Composition and Somatotype in Adolescent Competion Swimmers

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    José Miguel Martínez-Sanz

    2014-05-01

    Full Text Available Introduction: The swimmer is a high level athlete, with long limbs, and whose musculoskeletal components are important in sporting success. However, the fat component is paradoxical because of its relationship with the buoyancy and displacement of the body in the water. The aim of this study is to describe the anthropometric profile of adolescent competition swimmers.Material and methods: A total of 17 adolescent swimmers were evaluated, 10 boys (13.2 ±1.32 years and 7 girls (15±1.83 years. A qualified anthropometrist took anthropometric measures according to the protocol of the Society for the Advancement of Kinanthropometry (ISAK, with approved materials according to the methodology of Marfell-Jones et al, 2003. Body composition was calculated according to the consensus of Kinanthropometry and somatotype with Heath-Carter´s method.Results: Of all the variables studied (weight, height, folds, circumferences, diameters and lengths, significant differences were found (P<.05 between the sexes in height, arm span, skinfolds (triceps, subscapular, crestailiaca, ileo-spinal, abdominal, thigh, leg, sum of skinfolds, biacromial-bi-iliac index, bone body mass, muscle and fat, ectomorphy, and endomorphy.Conclusions: There are significant anthropometric differences between genders in adolescent swimmers (P<.05. Such differences, resulting in the development of both sexes, might be highly related to athletic performance of young athletes.

  13. [Endocrine obesity: bioelectric profiles (biotypes) detected in the body composition].

    Science.gov (United States)

    Miggiano, G A D; Petitti, T

    2004-09-01

    136 patients were selected (16 men and 120 women with non-specific menstrual disturbances) with a BMI (Body Mass Index) between 25 and 45 kg/m2, which were diagnosed with "disendocrinia" (GH deficit, hyperadrenocorticism, hypothyroidsm, hyperandrogenism, menstrual cycle disorders). The proposed approach, based on the visualization of the value distribution of the electric measures in different graphics, is able to immediately explain the bioelectric state of the individual's lean-mass. Subjects with hypothyroidism present, along with their overweight, less bio-conducting mass, with an altered fluid intra/extra-cellular distribution. Patients with hyperadrenocorticism show instead an hyperhydratation of the body mass, especially in the extracellular level. Patients with menstrual disorders (amenorrea, polycystic ovary syndrome, anovulatory cycle etc...) present a lean mass reduction (elevated Rs) and an increase of the intra-cellular compartment (elevated-Xc). Patients with hyper-androgenism (and hirsutism) show a characteristic bioelectric "pattern", with low Rs levels and high Xc levels. Subjects with GH deficit (men and women), has a trend of documenting bioelectric measures with lower lean mass and higher fat-mass. Different electric biotypes seem to characterize the body composition in the several endocrine disorders.

  14. Central Composite Design (CCD) applied for statistical optimization of glucose and sucrose binary carbon mixture in enhancing the denitrification process

    Science.gov (United States)

    Lim, Jun-Wei; Beh, Hoe-Guan; Ching, Dennis Ling Chuan; Ho, Yeek-Chia; Baloo, Lavania; Bashir, Mohammed J. K.; Wee, Seng-Kew

    2016-12-01

    The present study provides an insight into the optimization of a glucose and sucrose mixture to enhance the denitrification process. Central Composite Design was applied to design the batch experiments with the factors of glucose and sucrose measured as carbon-to-nitrogen (C:N) ratio each and the response of percentage removal of nitrate-nitrogen (NO3 --N). Results showed that the polynomial regression model of NO3 --N removal had been successfully derived, capable of describing the interactive relationships of glucose and sucrose mixture that influenced the denitrification process. Furthermore, the presence of glucose was noticed to have more consequential effect on NO3 --N removal as opposed to sucrose. The optimum carbon sources mixture to achieve complete removal of NO3 --N required lesser glucose (C:N ratio of 1.0:1.0) than sucrose (C:N ratio of 2.4:1.0). At the optimum glucose and sucrose mixture, the activated sludge showed faster acclimation towards glucose used to perform the denitrification process. Later upon the acclimation with sucrose, the glucose uptake rate by the activated sludge abated. Therefore, it is vital to optimize the added carbon sources mixture to ensure the rapid and complete removal of NO3 --N via the denitrification process.

  15. Postprandial insulin action relies on meal composition and hepatic parasympathetics: dependency on glucose and amino acids: Meal, parasympathetics & insulin action.

    Science.gov (United States)

    Afonso, Ricardo A; Gaspar, Joana M; Lamarão, Iva; Lautt, W Wayne; Macedo, M Paula

    2016-01-01

    Insulin sensitivity (IS) increases following a meal. Meal composition affects postprandial glucose disposal but still remains unclear which nutrients and mechanisms are involved. We hypothesized that gut-absorbed glucose and amino acids stimulate hepatic parasympathetic nerves, potentiating insulin action. Male Sprague-Dawley rats were 24 h fasted and anesthetized. Two series of experiments were performed. (A) IS was assessed before and after liquid test meal administration (10 ml.kg(-1), intraenteric): glucose + amino acids + lipids (GAL, n=6); glucose (n=5); amino acids (n=5); lipids (n=3); glucose + amino acids (GA, n=9); amino acids + lipids (n=3); and glucose + lipids (n=4). (B) Separately, fasted animals were submitted to hepatic parasympathetic denervation (DEN); IS was assessed before and after GAL (n=4) or GA administration (n=4). (A) Both GAL and GA induced significant insulin sensitization. GAL increased IS from 97.9±6.2 mg glucose/kg bw (fasting) to 225.4±18.3 mg glucose/kg bw (Pamino acids trigger a vagal reflex that involves hepatic parasympathetic nerves.

  16. Effects of NUTRIOSE® dietary fiber supplementation on body weight, body composition, energy intake, and hunger in overweight men.

    Science.gov (United States)

    Guerin-Deremaux, Laetitia; Li, Shuguang; Pochat, Marine; Wils, Daniel; Mubasher, Mohamed; Reifer, Cheryl; Miller, Larry E

    2011-09-01

    The objective of the present study was to determine the effectiveness of a soluble dietary fiber, NUTRIOSE(®), on body weight, body composition, energy intake and hunger in overweight Chinese men. The volunteers were randomized in double-blind fashion to 250 ml fruit juice supplemented with NUTRIOSE(®) (Test, n = 60) or a maltodextrin (Control, n = 60) at a dosage of 17 g twice daily for 12 weeks. Body weight, body composition were performed at 0, 4, 8 and 12 weeks while daily energy intake and hunger were assessed every 3 days. Test subjects had reductions in body weight (1.5 kg, P men.

  17. THE EFFECTS OF SYNCHRONIZATION OF CARBOHYDRATE AND PROTEIN SUPPLY IN SUGARCANE BAGASSE BASED RATION ON BODY COMPOSITION OF SHEEP

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    N. E. Wati

    2016-03-01

    Full Text Available The objective of this research was to study the effects of synchronization of carbohydrate and protein supply in sugarcane bagasse based ration on the body composition of sheep. The study was consisted of two steps of experiment. The first step of experiment used two rumen cannulated adult rams to create formulation of three diets with different synchronization index, namely 0.37; 0.50 and 0.63 respectively. The experimental diets were designed to be iso-energy, iso-nitrogenous and iso-neutral detergent fibre (iso-NDF. The second step of experiment was to determine the body composition of sheep fed the experimental diets, which were created in the first experiment. The body composition of fifteen rams were determined on week 0; 4; and 8 of experimental period, these were accomplished using the technique of urea dilution. The alteration of synchronization index did not affect on feed intake, ratio of ruminal acetate to propionate and serum glucose concentration, but dry matter (DM digestibility was affected (P<0.05 by the treatment of synchronization index in the diet. The alteration of synchronization index in the diet did not affect on the percentage of body protein, fat and water significantly, though body weight of sheep gained slightly during the experimental period.

  18. A STUDY ON BODY COMPOSITION, BODY COMPONENTS AND SOMATOTYPE CHARACTERISTICS OF SOCCER PLAYERS

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    Recep KÜRKÇÜ

    2009-08-01

    Full Text Available The aim of this study is to study to determine and comparison the body composition, body components and somatotype characteristics of young soccer players (Young Soccer Team of Sport Club of Muğla University with other national and international soccer players. Subjects were eighteen pubescent soccer players (age, 13.22y of a team playing in regional soccer league. Skinfolds (biceps, triceps, back, suprailiac, abdominal, leg, thigh, diameters (femur and humerus biconduler, circumferences (biceps, thigh of the body and body fat parameters were measured. Somatotype characteristics were calculated and evaluated by Heat-Carter formula. Subjects’ measurements were as; height 158.44±10.42cm, body weight 47.65±8.38kg, skinfolds; biceps 5.75±1.54mm, triceps 10.61±2.93mm, back 7.30±1.59mm, suprailiac 7.00±2.04mm, abdominal 9.91±3.98mm, leg 13.52±4.76mm; diameters; femur biconduler 11.03±0.74cm; humerus biconduler 7.30±0.59cm; circumferences, biceps 22.76±3.11cm, thigh 32.84±3.33cm and body fat percentage 5.41±1.37 %, somatotype characteristics; Endomorph; 4.59±2.08, Mezomorph; 6.94±3.10, and Ecthomorph; 3.55±1.34. In related sports, physical fitness parameters including physical and anthropometric characteristics of athletes are very important in talent identification. Therefore, results of the present study could provide important data on selection of talented players in soccer and to the other related researches.

  19. Body composition in adults with neurofibromatosis type 1

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    MARCIO SOUZA

    Full Text Available SUMMARY Objective To evaluate the body composition and nutritional status of neurofibromatosis type 1 (NF1 adult patients. Method A cross-sectional study of 60 NF1 patients (29 men, 31 women aged ≥ 18 years who were evaluated from September 2012 to September 2013 in a Neurofibromatosis Outpatient Reference Center. Patients underwent nutritional assessment including measurements of weight, stature, waist circumference (WC, upper-arm circumference (UAC, and skinfolds (biceps, triceps, subscapular, suprailiac. Body mass index (BMI, upper-arm total area (UATA, upper-arm muscle area (UAMA, upper-arm fat area (UAFA, body fat percentage (BFP, fat mass, fat-free mass, fat mass index, and fat-free mass index were also calculated. Results The mean age of the study population was 34.48±10.33 years. The prevalence of short stature was 28.3%. Low weight was present in 10% of the sample and 31.7% of patients had a BMI ≥ 25 kg/m2. Reduced UAMA (<5th percentile was present in 43.3% and no difference was found in UAFA between the sexes. The BFP was considered high in 30% and 17 (28.3% patients had a WC above the World Health Organization cutoffs. Conclusion In this study, NF1 patients had a high prevalence of underweight, short stature, and reduced UAMA, with no difference between the sexes. Reduced UAMA was more prevalent in underweight patients; however, this was also observed in the normal and overweight patients. Further studies should investigate the distribution of body tissues in NF1 patients, including differences between men and women, and the influence of diet and nutrition on clinical features in NF1.

  20. Body composition and net energy requirements of Brazilian Somali lambs

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    Elzânia S. Pereira

    2014-12-01

    Full Text Available The aim of this study was to determine the energy requirements for maintenance (NEm and growth of 48 Brazilian Somali ram lambs with an average initial body weight of 13.47±1.76 kg. Eight animals were slaughtered at the trials beginning as a reference group to estimate the initial empty body weight (EBW and body composition. The remaining animals were assigned to a randomised block design with eight replications per block and five diets with increasing metabolisable energy content (4.93, 8.65, 9.41, 10.12 and 11.24 MJ/kg dry matter. The logarithm of heat production was regressed against metabolisable energy intake (MEI, and the NEm (kJ/kg0.75 EBW/day were estimated by extrapolation, when MEI was set at zero. The NEm was 239.77 kJ/kg0.75 EBW/day. The animal’s energy and EBW fat contents increased from 11.20 MJ/kg and 208.54 g/kg to 13.54 MJ/kg and 274.95 g/kg of EBW, respectively, as the BW increased from 13 to 28.70 kg. The net energy requirements for EBW gain increased from 13.79 to 16.72 MJ/kg EBW gain for body weights of 13 and 28.70 kg. Our study indicated the net energy requirements for maintenance in Brazilian Somali lambs were similar to the values commonly recommended by the United States’ nutritional system, but lower than the values recommended by Agricultural Research Council and Commonwealth Scientific and Industrial Research Organization. Net requirements for weight gain were less compared to the values commonly recommended by nutritional system of the United States.

  1. Body Composition and Pulmonary Function in Cystic Fibrosis

    Science.gov (United States)

    Sheikh, Saba; Zemel, Babette S.; Stallings, Virginia A.; Rubenstein, Ronald C.; Kelly, Andrea

    2014-01-01

    Background: Lower body mass index (BMI) is associated with worse pulmonary function in cystic fibrosis (CF). Hypothesis: lean body mass (LBM) is more strongly associated with pulmonary function than BMI is. Methods: Anthropometrics, body composition by dual x-ray absorptiometry, and pulmonary function were determined in pancreatic insufficient CF (PI-CF) youth. Sex and age-adjusted Z-scores (BMI-Z, LBMI-Z, FMI-Z) were generated for CF and controls. (1) Associations of BMI-Z with LBMI-Z and FMI-Z and (2) age-adjusted associations of BMI-Z, LBMI-Z, and FMI-Z with FEV1%-predicted were tested. Results: Two hundred eight PI-CF subjects had lower BMI-Z, LBMI-Z, and FMI-Z compared to 390 controls. BMI-Z was associated with lower LBMI-Z (p < 0.0001) in PI-CF. In females, LBMI-Z and BMI-Z were positively associated with FEV1%-predicted; this relationship did not persist for FMI-Z after adjustment for LBMI-Z. In males, only LBMI-Z and BMI-Z were associated with FEV1%-predicted. Conclusion: In PI-CF youth, deficits in LBM were apparent. At lower BMI percentiles, BMI may not accurately depict LBM in PI-CF. In under-nourished PI-CF youth, this preservation of FM in preference to LBM is relevant since LBMI-Z, but not FMI-Z, is positively associated with FEV1%-predicted. Lean body mass index is more strongly associated with lung function compared to BMI, especially in the under-nourished child and adolescent with PI-CF. PMID:24783186

  2. Obesity, body composition and metabolic disturbances in polycystic ovary syndrome

    DEFF Research Database (Denmark)

    Svendsen, Pernille Fog; Nilas, Lisbeth; Nørgaard, Kirsten

    2008-01-01

    BACKGROUND: We determined the impact of polycystic ovary syndrome (PCOS) and obesity on glucose and lipid metabolism and beta-cell function in women with PCOS. METHODS: In 35 women with PCOS (17 lean, lean PCOS and 18 obese, obese PCOS) and 25 control women (9 lean, lean controls and 16 obese......-stimulated glucose oxidation (GOX 2) (P metabolism (P obese women with PCOS, ISI......, obese controls), beta-cell function was evaluated by the first-phase insulin response after intravenous glucose, acute insulin response to glucose (AIRg); insulin sensitivity, determined as insulin sensitivity index (ISI), was evaluated by the euglycemic hyperinsulinemic clamp. Indirect calorimetry...

  3. Influence of caffeine used at various temperature ranges on the concentrations of glucose and total serum protein as well as body weight gain in pregnant rats

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    Cendrowska-Pinkosz Monika

    2014-06-01

    Full Text Available Caffeine (120 mg/kg was administered intragastrically to pregnant rats daily on gestational days 8-21. An increase in serum concentration of glucose and total protein was found in animals, which were given caffeine. The protein content proved to be highly significant in the experimental group of animals. The control group showed a negative interdependence between body weight gain and glucose concentration. No correlation was found between body weight gain and total protein concentration, yet the glucose concentration significantly influenced the total protein concentration in this group of animals. Among animals which received caffeine, correlations between total protein and glucose concentrations were observed. The analysis did not show that the glucose or total protein concentration significantly influenced the body weight gain of pregnant female rats in the experimental group. The research conducted suggests the possibility of modulating effects of caffeine on adaptive processes during pregnancy.

  4. Relationship of sarcopenia and body composition with osteoporosis.

    Science.gov (United States)

    He, H; Liu, Y; Tian, Q; Papasian, C J; Hu, T; Deng, H-W

    2016-02-01

    The purpose of the study is to investigate the relationship between sarcopenia and body composition and osteoporosis in cohorts of three different races with a total of 17,891 subjects. Lean mass and grip strength were positively associated with bone mineral densities (BMDs). Subjects with sarcopenia were two times more likely to have osteoporosis compared with normal subjects. The relationship between sarcopenia and osteoporosis is not totally clear. First, the present study assessed this relationship by using two different definitions for sarcopenia. Second, we examined the associations of body composition (including muscle mass as a major and important component) and muscle strength on regional and whole-body BMDs. In total, 17,891 subjects of African American, Caucasian, and Chinese ethnicities were analyzed. Sarcopenia was defined by relative appendicular skeletal muscle mass (RASM) cut points and also by the definition of the European Working Group on Sarcopenia in Older People (low RASM plus low muscle function). Multiple regression analyses were conducted to examine the association of fat mass, lean mass (including muscle mass), and grip strength with regional and whole-body BMDs. Multivariate logistic regression analysis was performed to explore the association between sarcopenia and osteopenia/osteoporosis. BMDs were positively associated with lean mass and negatively associated with fat mass, after controlling for potential confounders. Grip strength was significantly associated with higher BMDs. Each standard deviation (SD) increase in RASM resulted in a ~37 % reduction in risk of osteopenia/osteoporosis (odds ratio (OR) = 0.63; 95 % confidence interval (CI) = 0.59, 0.66). Subjects with sarcopenia defined by RASM were two times more likely to have osteopenia/osteoporosis compared with the normal subjects (OR = 2.04; 95 % CI = 1.61, 2.60). Similarly, subjects with sarcopenia (low muscle mass and low grip strength) were ~1.8 times more

  5. The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects.

    Science.gov (United States)

    Kamphuis, M M J W; Lejeune, M P G M; Saris, W H M; Westerterp-Plantenga, M S

    2003-07-01

    To study the effects of 13 weeks conjugated linoleic acid (CLA) supplementation in overweight subjects after weight loss on weight regain, body composition, resting metabolic rate, substrate oxidation, and blood plasma parameters. This study had a double-blind, placebo-controlled randomized design. Subjects were first submitted to a very-low-calorie diet (VLCD 2.1 MJ/d) for 3 weeks after which they started with the 13-week intervention period. They either received 1.8 g CLA or placebo per day (low dosage, LD) or 3.6 g CLA or placebo per day (high dosage, HD). A total of 26 men and 28 women (age 37.8+/-7.7 y; body mass index (BMI) 27.8+/-1.5 kg/m(2)). Before VLCD (t=-3), after VLCD but before CLA or placebo intervention (t=0) and after 13-week CLA or placebo intervention (t=13), body weight, body composition (hydrodensitometry and deuterium dilution), resting metabolic rate, substrate oxidation, physical activity, and blood plasma parameters (glucose, insulin, triacylglycerol, free fatty acids, glycerol and beta-hydroxy butyrate) were measured. The VLCD significantly lowered body weight (6.9+/-1.7%), %body fat, fat mass, fat-free mass, resting metabolic rate, respiratory quotient and plasma glucose, insulin, and triacylglycerol concentrations, while free fatty acids, glycerol and beta-hydroxy butyrate concentrations were increased. Multiple regression analysis showed that at the end of the 13-week intervention, CLA did not affect %body weight regain (CLA LD 47.9+/-88.2%, CLA HD 27.4+/-29.8%, Placebo LD 32.0+/-42.8%, Placebo HD 22.5+/-37.9%). The regain of fat-free mass was increased by CLA (LD 6.2+/-3.9, HD 4.6+/-2.4%) compared to placebo (LD 2.8+/-3.2%, HD 3.4+/-3.6%), independent of %body weight regain and physical activity. As a consequence of an increased regain of fat-free mass by CLA, resting metabolic rate was increased by CLA (LD 12.0+/-11.4%, HD 13.7+/-14.4%) compared to placebo (LD 9.1+/-11.0%, HD 8.6+/-8.5%). Substrate oxidation and blood plasma

  6. Temperature control of thermal radiation from composite bodies

    Science.gov (United States)

    Jin, Weiliang; Polimeridis, Athanasios G.; Rodriguez, Alejandro W.

    2016-03-01

    We demonstrate that recent advances in nanoscale thermal transport and temperature manipulation can be brought to bear on the problem of tailoring thermal radiation from wavelength-scale composite bodies. We show that such objects—complicated arrangements of phase-change chalcogenide (Ge2Sb2Te5 ) glasses and metals or semiconductors—can be designed to exhibit strong resonances and large temperature gradients, which in turn lead to large and highly directional emission at midinfrared wavelengths. We find that partial directivity depends sensitively on a complicated interplay between shape, material dispersion, and temperature localization within the objects, requiring simultaneous design of the electromagnetic scattering and thermal properties of these structures. Our calculations exploit a recently developed fluctuating-volume current formulation of electromagnetic fluctuations that rigorously captures radiation phenomena in structures with strong temperature and dielectric inhomogeneities, such as those studied here.

  7. The elite athlete - assessing body shape, size, proportion and composition.

    Science.gov (United States)

    Kerr, D A; Ackland, T R; Schreiner, A B

    1995-03-01

    In the quest to optimize performance of the elite athlete the sport scientist has sought to determine the ideal physique for a given sport or event. For some sports, specific structural characteristics offer definite performance advantages; for example in rowing, in addition to height, a large arm span has been identified as important. In other sports. such as long distance running, low levels of adiposity or 'fatness' appear to be linked with faster running times. There are four areas where appraisal of the athlete's physique can provide useful information: (1) identification of talented athletes; (2) to assess and monitor the growing athlete; (3) to monitor training and performance; and (4) to determine 'race weight' in weight-category sports. As a research tool a particular method must be reliable and valid. Other considerations include how expensive the method is, if it is suitable for a field situation and if large amounts of data on a number of subjects can be collected quickly. The method should be safe for both the athlete and the tester and provide useful feedback for the athlete or coach. Anthropometry, with training is able to fulfil most of these criteria and is the most widely used method of physique assessment in sports science. Large anthropometric data bases have been collected on elite athletes at Olympic games and world championships according to a standard protocol. Kinanthropometry, which has developed from anthropometry, is concerned with measurement and evaluation of different aspects of human movement and individual variation in body shape, size, proportion and composition. For the assessment of adiposity a sum of skinfolds, usually over six sites, is most commonly used rather than percentage body fat formulae. Muscle mass can be assessed indirectly through girth and corrected girth measurements. Limb lengths and breadths are used to assess skeletal structure and proportional differences in limb size. The anthropometric methods most commonly

  8. Three-body system metaphor for the two-slit experiment and Escherichia coli lactose-glucose metabolism.

    Science.gov (United States)

    Asano, Masanari; Khrennikov, Andrei; Ohya, Masanori; Tanaka, Yoshiharu; Yamato, Ichiro

    2016-05-28

    We compare the contextual probabilistic structures of the seminal two-slit experiment (quantum interference experiment), the system of three interacting bodies andEscherichia colilactose-glucose metabolism. We show that they have the same non-Kolmogorov probabilistic structure resulting from multi-contextuality. There are plenty of statistical data with non-Kolmogorov features; in particular, the probabilistic behaviour of neither quantum nor biological systems can be described classically. Biological systems (even cells and proteins) are macroscopic systems and one may try to present a more detailed model of interactions in such systems that lead to quantum-like probabilistic behaviour. The system of interactions between three bodies is one of the simplest metaphoric examples for such interactions. By proceeding further in this way (by playing withn-body systems) we shall be able to find metaphoric mechanical models for complex bio-interactions, e.g. signalling between cells, leading to non-Kolmogorov probabilistic data.

  9. Body composition of preschool children and relation to birth weight

    Directory of Open Access Journals (Sweden)

    Thais Costa Machado

    2014-01-01

    Full Text Available Objective: to evaluate the relationship between body composition of preschool children suffering from excess weight and birth weight (BW. Methods: probabilistic sample, by conglomerates, with 17 daycare centers (of a total of 59 composing a final sample of 479 children. We used Z-score of Body Mass Index (zBMI ≥ +1 and ≥ +2, respectively, to identify preschool children with risk of overweight and excess weight (overweight or obesity. The arm muscle area (AMA and the arm fat area (AFA were estimated from measurements of arm circumference, triceps skin fold thickness. Results: the prevalence of risk of overweight was 22.9% (n=110 and excess weight was 9.3% (n=44. The risk of overweight and excess weight in children did not show correlation between BW and AFA, but it did with adjusted arm muscle area (AMAa (rp= 0.21; p= 0.0107. The analysis of the group with excess weight alone also showed a positive correlation between BW and AMAa (rp= 0.42; p= 0.0047. Conclusion: among overweight children, lower BW is associated with a lower arm muscle area in early preschool age, regardless of the fat arm area presented by them.

  10. [Aging and body composition: the sarcopenic obesity in Spain].

    Science.gov (United States)

    Gómez-Cabello, A; Vicente Rodríguez, G; Vila-Maldonado, S; Casajús, J A; Ara, I

    2012-01-01

    The increase in life expectancy occurred during the last decades has resulted in a growth of the elderly population, being estimated that a third of the Spanish population will be elderly (> 65 years) in the year 2050. Human aging involves many changes, such as a variation in body composition. Different factors work together leading to an increase in fat mass, decreased muscle mass and reduced bone mass among seniors. These characteristic changes among elderly people may lead to suffer several diseases such as obesity, sarcopenia and osteoporosis and may result in decreased quality of life, increased dependence and increased risk of mortality in this population. In the late 90's, "sarcopenic obesity" was a concept that emerged in order to define those people who simultaneously have an excess of body fat and a significant loss of muscle mass. Recently, for the first time in Spain (the elderly EXERNET multi-centre study), it has been shown that the prevalence of sarcopenic obesity in a representative sample of non-institutionalized seniors reaches values of 15%.

  11. Body composition of physically active women aged over 60

    Directory of Open Access Journals (Sweden)

    Héctor Antonio Herrera Mogollón

    2007-09-01

    Full Text Available With the objective of analyzing the body composition of physical active seniors: 116 women enrolled on the Program of Integrated Care for the older Adult in the Municipality of Chacao, Venezuela, were studied. Anthropometric variables were measured. Comparisons between variables revealed no statistical differences, with the exception of suprailiac skinfolds (p <0,05. Results indicated that most of the mean values were lower in the oldest group, with the exception of height, which was greater. The waist/hip ratio remained constant. More than 50% of women exhibited good nutritional status with appropriate body mass index. Cases of energy malnutrition were observed (defi ciencies and excesses, with overweight prevailing at around 20%. Waist circumference and the waist/hip ratio indicated that around 55% of the sample exhibited a high risk of developing chronic non-infectious illnesses. Comparisons with other population samples indicated greater similarity with those in their environment (Venezuelan and Mexican samples and with Italian and Australian women, and distant from the American pattern, with minor values of the variables compared.

  12. Electrospun poly(vinylidene fluoride)/poly(aminophenylboronic acid) composite nanofibrous membrane as a novel glucose sensor.

    Science.gov (United States)

    Manesh, K M; Santhosh, P; Gopalan, A; Lee, Kwang-Pill

    2007-01-15

    Electrospinning was used to prepare the nanofibrous membrane (NFM) of the composite comprising poly(vinylidene fluoride) and poly(aminophenylboronic acid) (PVdF/PAPBA-NFM). The PVdF/PAPBA-NFM displayed an excellent linear response to the detection of glucose for the concentration range of 1 to 15mM with a response time of less than 6s. Further experiments on amperometric sensing of glucose were performed in the presence of interferents such as uric acid, ascorbic acid, acetaminophen, fructose, mannose, etc. using PVdF/PAPBA-NFM. The interferents did not give significant overlapping current signal during the determination of glucose. Also, PVdF/PAPBA-NFM possesses better reproducibility toward glucose detection and storage stability.

  13. Abdominal body composition differences in NFL football players.

    Science.gov (United States)

    Bosch, Tyler A; Burruss, T Pepper; Weir, Nate L; Fielding, Kurt A; Engel, Bryan E; Weston, Todd D; Dengel, Donald R

    2014-12-01

    The purpose of this study was to examine visceral fat mass as well as other measures abdominal body composition in National Football League (NFL) players before the start of the season. Three hundred and seventy NFL football players were measured before the start of the season using dual-energy x-ray absorptiometry. Regional fat and lean mass was measured for each player. Players were categorized into 3 groups based on positions that mirror each other: linemen; linebackers/tight ends/running backs and wide receivers/defensive backs. Significant differences were observed between the position groups for both lean and fat regional measurements. However, the magnitude of difference was much greater for fat measures than lean measures. Additionally, a threshold was observed (∼114 kg) at which there is a greater increase in fat accumulation than lean mass accumulation. The increase in fat accumulation is distributed to the abdominal region where thresholds were observed for subcutaneous abdominal fat accumulation (12.1% body fat) and visceral abdominal fat accumulation (20.1% body fat), which likely explains the regional fat differences between groups. The results of this study suggest that as players get larger, there is more total fat than total lean mass accumulation and more fat is distributed to the abdominal region. This is of importance as increased fat mass may be detrimental to performance at certain positions. The thresholds observed for increased abdominal fat accumulation should be monitored closely given recent research observed that abdominal obesity predicts lower extremity injury risk and visceral adipose tissue's established association with cardiometabolic risk.

  14. Are immunoglobulin concentrations associated with the body composition of adolescents?

    Science.gov (United States)

    Zúñiga-Torres, María G; Martínez-Carrillo, Beatriz E; Pardo-Morales, Rosa V; Wärnberg, Julia; Marcos, Ascensión; Benítez-Arciniega, Alejandra D; Valdés-Ramos, Roxana

    2009-11-01

    The aim of this study was to analyze the association between serum concentrations of immunoglobulins (Ig) A, G, and M and body composition of adolescents from Mexico. Informed consent was obtained from parents and assent was obtained from the adolescents for the evaluation of 125 adolescents from the Capital city of Toluca and the adjacent semiurban county of Lerma de Villada. Height, weight, waist, and hip circumference were measured by trained personnel. Body mass index and waist:hip ratio were calculated from these measurements, whereas body fat (BF) was calculated from tricipital and subscapular skinfolds and measured by bioelectrical impedance. Serum concentrations of Ig were determined by nephelometry. Data were analyzed by independent samples t test and Pearson correlations. Subjects were mainly females (71.2%), with a mean age of 16.8 years (+/-0.8). No differences were reported in all indicators by weight or BF between gender. Female participants had higher Ig concentrations than males (IgG t = 2.24, p = 0.027; IgA t = 2.05, p = 0.043; IgM t = 4.49, p < 0.001). Positive correlations were reported for IgA and IgM with tricipital skinfold (r = 0.192, p = 0.041; and r = 0.221, p = 0.018, respectively) and for total BF by bioimpedance (r = 0.243, p = 0.009). Ig concentrations do not seem to be affected by overweight, obesity, or excessive or central BF in adolescents.

  15. Sedentary Activity and Body Composition of Middle School Girls: The Trial of Activity for Adolescent Girls

    Science.gov (United States)

    Pratt, Charlotte; Webber, Larry S.; Baggett, Chris D.; Ward, Dianne; Pate, Russell R.; Murray, David; Lohman, Timothy; Lytle, Leslie; Elder, John P.

    2008-01-01

    This study describes the relationships between sedentary activity and body composition in 1,458 sixth-grade girls from 36 middle schools across the United States. Multivariate associations between sedentary activity and body composition were examined with regression analyses using general linear mixed models. Mean age, body mass index, and…

  16. Body composition and diet of Chinese, Malays and Indians in Singapore

    NARCIS (Netherlands)

    Deurenberg-Yap, M.

    2000-01-01

    This thesis describes the studies on body composition and dietary intakes of the three major ethnic groups residing in Singapore, and how these are related to cardiovascular risk factors in these groups.Body composition : Body fat percentage was measured using a four-compartment model described by B

  17. School-Based BMI and Body Composition Screening and Parent Notification in California: Methods and Messages

    Science.gov (United States)

    Madsen, Kristine A.; Linchey, Jennifer

    2012-01-01

    Background: School-based body mass index (BMI) or body composition screening is increasing, but little is known about the process of parent notification. Since 2001, California has required annual screening of body composition via the FITNESSGRAM, with optional notification. This study sought to identify the prevalence of parental notification…

  18. School-Based BMI and Body Composition Screening and Parent Notification in California: Methods and Messages

    Science.gov (United States)

    Madsen, Kristine A.; Linchey, Jennifer

    2012-01-01

    Background: School-based body mass index (BMI) or body composition screening is increasing, but little is known about the process of parent notification. Since 2001, California has required annual screening of body composition via the FITNESSGRAM, with optional notification. This study sought to identify the prevalence of parental notification…

  19. Whole body air displacement plethysmography compared with hydrodensitometry for body composition analysis.

    Science.gov (United States)

    Dewit, O; Fuller, N J; Fewtrell, M S; Elia, M; Wells, J C

    2000-02-01

    To assess the acceptability and feasibility of whole body air displacement plethysmography in children and to determine its precision and agreement with hydrodensitometry, an appropriate reference method. Age specific two component model equations were used to predict fat mass from body density in 22 children aged 8-12 years and in 10 adults for comparison of methods. Precision for each method was established from duplicate measurements. Plethysmography was accepted more readily than hydrodensitometry (100% v 69% provided duplicate measurements). Precision for fat mass in children was 0.38 kg by plethysmography and 0.68 kg by hydrodensitometry, and results were similar in adults. The mean (SD) fat mass in children was 6.9 kg (4.0) and 6.7 kg (4. 2) by plethysmography and hydrodensitometry, respectively, but 95% limits of agreement between methods were large (-4.1 kg to 3.5 kg fat). Plethysmography was more readily accepted and had better precision than hydrodensitometry. It also provided similar body composition results for the group but not for all individual children.

  20. Body composition as a frailty marker for the elderly community

    Directory of Open Access Journals (Sweden)

    Falsarella GR

    2015-10-01

    Full Text Available Gláucia Regina Falsarella,1 Lívia Pimenta Renó Gasparotto,1 Caroline Coutinho Barcelos,2 Ibsen Bellini Coimbra,1,2 Maria Clara Moretto,1 Mauro Alexandre Pascoa,3 Talita C B Rezende Ferreira,1 Arlete Maria Valente Coimbra1,41Gerontology Program, Faculty of Medical Sciences, 2Department of Medical Clinics, Faculty of Medical Sciences, 3Department Biodynamics of Movement, Faculty of Physical Education, 4Family Health Program, Gerontology Program, Faculty of Medical Sciences, State University of Campinas (Unicamp, Campinas, São Paulo, BrazilBackground: Body composition (BC in the elderly has been associated with diseases and mortality; however, there is a shortage of data on frailty in the elderly.Objective: To investigate the association between BC and frailty, and identify BC profiles in nonfrail, prefrail, and frail elderly people.Methods: A cross-sectional study comprising 235 elderly (142 females and 93 males aged ≥65 years, from the city of Amparo, State of São Paulo, Brazil, was undertaken. Sociodemographic and cognitive features, comorbidities, medication, frailty, body mass index (BMI, muscle mass, fat mass, bone mass, and fat percent (% data were evaluated. Aiming to examine the relationship between BC and frailty, the Mann–Whitney and Kruskal–Wallis nonparametric tests were applied. The statistical significance level was P<0.05.Results: The nonfrail elderly showed greater muscle mass and greater bone mass compared with the prefrail and frail ones. The frail elderly had greater fat % than the nonfrail elderly. There was a positive association between grip strength and muscle mass with bone mass (P<0.001, and a negative association between grip strength and fat % (P<0.001. Gait speed was positively associated with fat mass (P=0.038 and fat % (P=0.002. The physical activity level was negatively associated with fat % (P=0.022. The weight loss criterion was positively related to muscle mass (P<0.001, bone mass (P=0.009, fat mass

  1. Switching from high-fat to low-fat diet normalizes glucose metabolism and improves glucose-stimulated insulin secretion and insulin sensitivity but not body weight in C57BL/6J mice.

    Science.gov (United States)

    Agardh, Carl-David; Ahrén, Bo

    2012-03-01

    Environmental factors such as a high-fat diet contribute to type 2 diabetes and obesity. This study examined glycemia, insulin sensitivity, and β-cell function after switching from a high-fat diet to a low-fat diet in mice. C57BL/6J mice were fed a high-fat diet or low-fat diet for 18 months, after which mice on the high-fat diet either maintained this diet or switched to a low-fat diet for 4 weeks. Body weight and glucose and insulin responses to intraperitoneal glucose were determined. Insulin secretion (insulinogenic index: the 10-minute insulin response divided by the 10-minute glucose level) and insulin sensitivity (1 divided by basal insulin) were determined. After 18 months on a high-fat diet, mice had glucose intolerance, marked hyperinsulinemia, and increased body weight compared to mice on a low-fat diet (P diet to low-fat diet normalized glucose tolerance, reduced but not normalized body weight (P diet to low-fat diet normalizes glucose tolerance and improves but not normalizes insulin secretion and insulin sensitivity. These effects are more pronounced than the reduced body weight.

  2. Long term survey of body composition in hemodialysis patients using the Body Composition Monitor® (BCM

    Directory of Open Access Journals (Sweden)

    Stanislas Trolonge

    2012-06-01

    Full Text Available Since 2 years all 265 incident patients in self-dialysis units were included in a prospective study. Every 6-months, clinical and biological nutritional evaluation was associated to a BCM measure. 205 pts have a complete set of data at start (age 60±16 years, BMI 25±5 kg/m2, albumin 37±4 g/L, prealbumin 0.32±0.1 g/L, CRP median 5 mg/L, 135 pts at 6 mo and 56 pts at 2 years. Measures were performed before HD session to ensure stability and reproducibility of body fluid compartments by the same examiner. Lean and fat masses (lean tissue index: LTI, fat tissue index: FTI were normalized by square body height and compared with a reference range derived from 2000 healthy controls, according to gender and age. 28% of pts had values of LTI below the 10th percentile. A linear correlation exists (p<0.001 between pre-dialysis creatinine level and LTI. Albumin or prealbumin were not predictive of sarcopenia. Prescribed post dialysis BW was underestimated in 25% of pts and 16% remain overhydrated. In stable patients repeated measures analysis reveal no significant variation of LTI even in case of reevaluation of BW and gain of BW is associated with fat mass increase. BCM is a simple tool in clinical practice to evaluate body composition and hydratation status and help to guide nutritional support.

  3. Pregnancy outcome and prepregnancy body mass index in 2459 glucose-tolerant Danish women

    DEFF Research Database (Denmark)

    Jensen, Dorte Møller; Damm, Peter; Sørensen, Bente

    2003-01-01

    OBJECTIVE: This study was undertaken to investigate the relationship between pregnancy outcome and prepregnancy overweight or obesity in women with a normal glucose tolerance test. STUDY DESIGN: A historical cohort study of 2459 pregnant women systematically examined for gestational diabetes...... overweight and obesity is associated with adverse pregnancy outcome in glucose-tolerant women........0-29.9 kg/m(2)) and obese women (BMI >or= 30.0 kg/m(2)) compared with women who were of normal weight (BMI 18.5-24.9 kg/m(2)). The frequencies of shoulder dystocia, preterm delivery, and infant morbidity other than macrosomia were not significantly associated with maternal BMI. CONCLUSION: Prepregnancy...

  4. The Metabolic Syndrome in Obese Postmenopausal Women: Relationship to Body Composition, Visceral Fat, and Inflammation

    National Research Council Canada - National Science Library

    You, Tongjian; Ryan, Alice S; Nicklas, Barbara J

    2004-01-01

    The purpose of this study was to investigate whether aerobic fitness, body composition, body fat distribution, and inflammation are different in obese postmenopausal women with and without the metabolic syndrome (MS...

  5. Effect of Ethanolic Extract of Fragaria Vesca on serum glucose levels and body weight in diet induced obese rats

    Directory of Open Access Journals (Sweden)

    Venkat ramana Yella

    2015-10-01

    Full Text Available Objective: to evaluate the effect of ethanolic extract Fragaria Vesca on serum glucose levels in diet induced obese rats.Material and methods: Male Wister albino rats weighing 200- 250 gm, were divided into 3 groups of 6 animals each. The animals of all the groups except normal group were given a lipid diet consisting of cholesterol (1%, cholic acid (0.5%, casein (20%, choline (0.25%, d-l-methionin1(0.4%, coconut oil (25%, multi vitamin mix (3.5% and sucrose (48.4% with standard pellet diet for 30 days [20]. Growth rate was monitored during the treatment. Results: There was significantly decrease in blood glucose in standard group compared to HFD model (P< 0.05.  But there was no significant change among other groupsConclusion:  There was no significant change in the blood glucose level in all the groups except the standard group, but there was reduction in body weight.

  6. Fast-Food Restaurant Advertising on Television and Its Influence on Youth Body Composition

    OpenAIRE

    Grossman, Michael; Tekin, Erdal; Wada, Roy

    2012-01-01

    We examine the effects of fast-food restaurant advertising on television on the body composition of adolescents as measured by percentage body fat (PBF) and to assess the sensitivity of these effects to using conventional measures of youth obesity based on body-mass index (BMI). We merge measures of body composition from bioelectrical-impedance analysis (BIA) and dual-energy x-ray absorptiometry (DXA) from the National Health and Nutrition Examination Survey with individual level data from th...

  7. Evaluation of morphological indices and total body electrical conductivity to assess body composition in big brown bats

    Science.gov (United States)

    Pearce, R.D.; O'Shea, T.J.; Wunder, B.A.

    2008-01-01

    Bat researchers have used both morphological indices and total body electric conductivity (TOBEC) as proxies for body condition in a variety of studies, but have typically not validated these indices against direct measurement of body composition. We quantified body composition (total carcass lipids) to determine if morphological indices were useful predictors of body condition in big brown bats (Eptesicus fuscus). We also evaluated body composition indirectly by TOBEC using EM-SCAN?? technology. The most important predictors of body composition in multiple regression analysis were body mass-to-forearm ratio (partial r2 = 0.82, P < 0.001) followed by TOBEC measurement (partial r2 = 0.08, P < 0.001) and to a minor extent head length (partial r2 = 0.02, P < 0.05). Morphological condition indices alone may be adequate for some studies because of lower cost and effort. Marking bats with passive integrated transponder (PIT) tags affected TOBEC measurements. ?? Museum and Institute of Zoology PAS.

  8. Magnesium Affects Poly(3-hydroxybutyrate-co-4-hydroxybutyrate Content and Composition by Affecting Glucose Uptake in Delftia acidovorans

    Directory of Open Access Journals (Sweden)

    Lee, W. H.

    2007-01-01

    Full Text Available Precise control of polyhydroxyalkanoate (PHA composition is necessary in order to synthesize polymers with specific properties. Among the various types of PHA that have been identified, those that contain 4-hydroxybutyrate (4HB monomers are especially useful in the medical and pharmaceutical fields as absorbable biomaterial. In this study, we have investigated the effect of magnesium concentration on the biosynthesis of poly(3-hydroxybutyrate-co-4-hydroxybutyrate [P(3HB-co-4HB] by Delftia acidovorans DS-17. Our results show that, magnesium affects the copolymer content and composition by affecting glucose uptake from the culture medium. Higher concentrations of magnesium resulted in lower molar fractions of 3HB in the copolymer and reduced uptake of glucose. The results show for the first time that magnesium may be used to achieve fine control of biologically synthesized PHA copolymer composition.

  9. Associations between plasma branched-chain amino acids, β-aminoisobutyric acid and body composition.

    Science.gov (United States)

    Rietman, Annemarie; Stanley, Takara L; Clish, Clary; Mootha, Vamsi; Mensink, Marco; Grinspoon, Steven K; Makimura, Hideo

    2016-01-01

    Plasma branched-chain amino acids (BCAA) are elevated in obesity and associated with increased cardiometabolic risk. β-Aminoisobutyric acid (B-AIBA), a recently identified small molecule metabolite, is associated with decreased cardiometabolic risk. Therefore, we investigated the association of BCAA and B-AIBA with each other and with detailed body composition parameters, including abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). A cross-sectional study was carried out with lean (n 15) and obese (n 33) men and women. Detailed metabolic evaluations, including measures of body composition, insulin sensitivity and plasma metabolomics were completed. Plasma BCAA were higher (1·6 (se 0·08) (×10(7)) v. 1·3 (se 0·06) (×10(7)) arbitrary units; P = 0·005) in obese v. lean subjects. BCAA were positively associated with VAT (R 0·49; P = 0·0006) and trended to an association with SAT (R 0·29; P = 0·052). The association between BCAA and VAT, but not SAT, remained significant after controlling for age, sex and race on multivariate modelling (P BCAA were also associated with parameters of insulin sensitivity (Matsuda index: R -0·50, P = 0·0004; glucose AUC: R 0·53, P BCAA were not associated with B-AIBA (R -0·04; P = 0·79). B-AIBA was negatively associated with SAT (R -0·37; P = 0·01) but only trended to an association with VAT (R 0·27; P = 0·07). However, neither relationship remained significant after multivariate modelling (P > 0·05). Plasma B-AIBA was associated with parameters of insulin sensitivity (Matsuda index R 0·36, P = 0·01; glucose AUC: R -0·30, P = 0·04). Plasma BCAA levels were positively correlated with VAT and markers of insulin resistance. The results suggest a possible complex role of adipose tissue in BCAA homeostasis and insulin resistance.

  10. Alkaline vapor oxidation synthesis and electrocatalytic activity toward glucose oxidation of CuO/ZnO composite nanoarrays

    Science.gov (United States)

    Soejima, Tetsuro; Takada, Kohei; Ito, Seishiro

    2013-07-01

    CuO/ZnO nanocomposite materials have attracted widespread attention because of their scientific and technological importance as, for example, photocatalysts, gas and humidity sensors, catalysts for H2 production and organic synthesis, and solar cells. High-temperature and/or complicated multistep processes are usually used to prepare these composites. Here we demonstrate a low-temperature and facile one-step synthesis of CuO nanoflowers/ZnO nanorods composite arrays via an alkaline vapor oxidation process. The CuO/ZnO composite nanoarrays show high electrocatalytic activity toward glucose oxidation.

  11. Correlation of body mass index Z-scores with glucose and lipid profiles among overweight and obese children and adolescents.

    Science.gov (United States)

    Nogueira-de-Almeida, Carlos Alberto; Mello, Elza Daniel de

    2017-09-04

    To evaluate the prevalence of abnormalities in plasma lipid and glucose profiles among overweight and obese children and adolescents, and to assess the presence of a correlation between body mass index Z-scores and indicators of comorbidities related to both profiles. This was a multicenter cross-sectional study conducted at two outpatient clinics. The study included all 417 comers for the first visit from 2008 to 2012, aged between 7 and 18 years, with BMI above the Z-score +1. Anthropometry and blood sampling were obtained. The prevalence of dyslipidemias, hyperglycemia, and insulin resistance were evaluated, together with the correlations of these variables with the increase of Z-BMI. Dyslipidemia was observed in 43.4% of the boys and 66.1% of the girls, with no difference between genders. High glucose levels were detected in 6.2% of the individuals. Insulin resistance was present in 32.3% and 41.7% of the cases, with no statistical significance between boys and girls. Correlations between the Z-BMI were noted for triglycerides in the entire group and among girls; for HDL-c, only among girls; for glucose, a correlation was observed for the entire group, but not when stratified by gender. The indicators of insulin resistance were all correlated with Z-BMI, even when corrected for age. Overweight and obesity give origin to a high prevalence of dyslipidemia and insulin resistance. BMI Z-scores showed a weak positive correlation with glucose and triglyceride, and negative with HDL-c. In turn, the strongest positive correlation was found with insulin resistance indicators. Copyright © 2017 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.

  12. The effects of meal glycemic load on blood glucose levels of adults with different body mass indexes

    Directory of Open Access Journals (Sweden)

    Tuba Yalcin

    2017-01-01

    Full Text Available Aims: The aim was to determine the effect of meal glycemic load (GL on blood glucose levels of healthy people with different body mass indexes (BMIs. Methods: Thirty healthy controls were included in this study. The participants were divided into two groups according to their BMI as normal group (BMI = 18.5–24.9 kg/m2, n = 15 and overweight group (BMI = 25.0–29.9 kg/m2, n = 15. Dietary assessment was done by the 24-h recall method for 3 successive days. Cases were fed by breakfasts with two different GL on consecutive days. Energy values of the test meal, adjusted to meet 25% of daily energy requirements of each case, were identical in low and high GL meal (483 kcal and 482 kcal, respectively. Finger-prick capillary blood samples were taken on 0, 15, 30, 45, 60, 90, and 120 min. Results: Average daily energy intake in normal and overweight group was found as 2514.3 ± 223.8 kcal, 2064.1 ± 521.6 kcal and 2211.4 ± 368.7 kcal, 2494.8 ± 918 kcal in males and females, respectively. Blood glucose level was increased and remained more stable in both high GL meal groups compared to low (P < 0.05. The effects of GL on BMI classified groups were also found different. High GL meal was found to be more effective for increasing blood glucose level, especially on overweight group (P < 0.05. Conclusions: The effects of GL meal were found to be different on normal and overweight individuals. The high GL meals were more effective to increase the blood glucose level than low GL meal, especially on overweight people.

  13. [Body composition analysis in obesity: radionuclide and non radionuclide methods].

    Science.gov (United States)

    Tzotzas, Themistoklis; Krassas, Gerasimos E; Doumas, Argirios

    2008-01-01

    Body composition (BC) assessment provides important information regarding the absolute or relative amount of bone, lean and fat tissue. Different somatometric techniques have been applied in numerous epidemiological and experimental studies, as well as in every day clinical practice. Traditional techniques for BC analysis include skin fold thickness measurements, radioisotope dilution methods, hydrodensitometry and underwater weighing, while newer techniques include bioelectrical impedance analysis (BIA), air displacement plethysmography (ADP), dual energy X-rays absorptiometry (DEXA), computer tomography and magnetic resonance imaging. In addition, positron emission tomography helped to the functional investigation of adipose tissue, in particular of brown tissue. All these techniques have contributed a lot to the understanding of physiological conditions such as exercise training, menopause and ageing, adolescence health parameters, as well as pathological conditions such as disorders of nutrition, cancer, obesity and diabetes mellitus. In obesity, BC contributed to diagnosis and the pathological impact of visceral adipose tissue. In addition, conditions such as pseudo- or hypermuscular obesity and sarcopenia, which are often observed in various endocrine diseases, were investigated in detail by using such methods. During weight loss, some of these methods were quite accurate in measuring changes in fat and lean mass. Apart from anthropometric measurements, a BC measurement if possible should be included in obesity assessment. Measurements of skin fold thickness combined with BIA are quite sufficient for routine clinical practice. However, in specialized clinics and in research, more sophisticated methods like ADP or DEXA are used.

  14. Relationship among serum taurine, serum adipokines, and body composition during 8-week human body weight control program.

    Science.gov (United States)

    You, Jeong Soon; Park, Ji Yeon; Zhao, Xu; Jeong, Jin Seok; Choi, Mi Ja; Chang, Kyung Ja

    2013-01-01

    Human adipose tissue is not only a storage organ but also an active endocrine organ to release adipokines. This study was conducted to investigate the relationship among serum taurine and adipokine levels, and body composition during 8-week human body weight control program in obese female college students. The program consisted of diet therapy, exercise, and behavior modification. After the program, body weight, body fat mass, percent body fat, and body mass index (BMI) were significantly decreased. Serum triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels were significantly decreased. Also serum adiponectin level was significantly increased and serum leptin level was significantly decreased. There were no differences in serum taurine and homocysteine levels. The change of serum adiponectin level was positively correlated with change of body fat mass and percent body fat. These results may suggest that body fat loss by human body weight control program is associated with an increase in serum adiponectin in obese female college students. Therefore, further study such as taurine intervention study is needed to know more exact correlation between dietary taurine intake and serum adipokines or body composition.

  15. Gsα deficiency in adipose tissue improves glucose metabolism and insulin sensitivity without an effect on body weight.

    Science.gov (United States)

    Li, Yong-Qi; Shrestha, Yogendra B; Chen, Min; Chanturiya, Tatyana; Gavrilova, Oksana; Weinstein, Lee S

    2016-01-12

    Gsα, the G protein that transduces receptor-stimulated cAMP generation, mediates sympathetic nervous system stimulation of brown adipose tissue (BAT) thermogenesis and browning of white adipose tissue (WAT), which are both potential targets for treating obesity, as well as lipolysis. We generated a mouse line with Gsα deficiency in mature BAT and WAT adipocytes (Ad-GsKO). Ad-GsKO mice had impaired BAT function, absent browning of WAT, and reduced lipolysis, and were therefore cold-intolerant. Despite the presence of these abnormalities, Ad-GsKO mice maintained normal energy balance on both standard and high-fat diets, associated with decreases in both lipolysis and lipid synthesis. In addition, Ad-GsKO mice maintained at thermoneutrality on a standard diet also had normal energy balance. Ad-GsKO mice had improved insulin sensitivity and glucose metabolism, possibly secondary to the effects of reduced lipolysis and lower circulating fatty acid binding protein 4 levels. Gsα signaling in adipose tissues may therefore affect whole-body glucose metabolism in the absence of an effect on body weight.

  16. A whole-body model for glycogen regulation reveals a critical role for substrate cycling in maintaining blood glucose homeostasis.

    Directory of Open Access Journals (Sweden)

    Ke Xu

    2011-12-01

    Full Text Available Timely, and sometimes rapid, metabolic adaptation to changes in food supply is critical for survival as an organism moves from the fasted to the fed state, and vice versa. These transitions necessitate major metabolic changes to maintain energy homeostasis as the source of blood glucose moves away from ingested carbohydrates, through hepatic glycogen stores, towards gluconeogenesis. The integration of hepatic glycogen regulation with extra-hepatic energetics is a key aspect of these adaptive mechanisms. Here we use computational modeling to explore hepatic glycogen regulation under fed and fasting conditions in the context of a whole-body model. The model was validated against previous experimental results concerning glycogen phosphorylase a (active and glycogen synthase a dynamics. The model qualitatively reproduced physiological changes that occur during transition from the fed to the fasted state. Analysis of the model reveals a critical role for the inhibition of glycogen synthase phosphatase by glycogen phosphorylase a. This negative regulation leads to high levels of glycogen synthase activity during fasting conditions, which in turn increases substrate (futile cycling, priming the system for a rapid response once an external source of glucose is restored. This work demonstrates that a mechanistic understanding of the design principles used by metabolic control circuits to maintain homeostasis can benefit from the incorporation of mathematical descriptions of these networks into "whole-body" contextual models that mimic in vivo conditions.

  17. Anthropometric assessment of 10-y changes in body composition in the elderly.

    Science.gov (United States)

    Hughes, Virginia A; Roubenoff, Ronenn; Wood, Michael; Frontera, Walter R; Evans, William J; Fiatarone Singh, Maria A

    2004-08-01

    An increased central distribution of fat with advancing age is associated with chronic metabolic and cardiovascular abnormalities. Little is known about the magnitude or pattern of fat distribution and its association with healthy aging. This study describes approximately 10-y changes in body composition at 11 anthropometric sites in elderly persons and the metabolic and physical activity factors associated with these changes. Skinfold thicknesses, girths, body fat by hydrodensitometry, physical activity by questionnaire, and metabolic variables were examined twice, 9.4 +/- 1.4 y apart, in 54 men and 75 women aged 60.4 +/- 7.8 y at baseline. Subcutaneous fat declined (-17.2%; P < 0.001), whereas total fat mass increased (7.2%; P < 0.05). Waist and hip circumference changes were the best anthropometric predictors of total fat mass change (r(2) = 0.40-0.65, P < 0.0001). Thigh girth change was more strongly associated with fat-free mass change (r(2) = 0.22, P < 0.01) than with fat mass change (r(2) = 0.07, P < 0.05) in women. An increase in physical activity was associated with an attenuation of thigh girth decline in men and women (F ratio = 5.13, P < 0.007). Traditional metabolic markers of visceral adiposity (triacylglycerol, glucose, and total cholesterol) were not significantly related to the change in waist circumference. Skinfold thicknesses cannot be used to assess changes in body fat mass because of age-related fat redistribution. Higher levels of physical activity can attenuate the decline in appendicular lean tissue expected over 10 y. Waist and thigh girths, rather than skinfold thicknesses, should be considered for use in longitudinal studies in the elderly because the changes in these girths capture increased abdominal adiposity and sarcopenia, respectively.

  18. Study of Body Composition and Metabolic Parameters in HIV-1 Male Patients

    Directory of Open Access Journals (Sweden)

    Gurudath Gundurao Sreekantamurthy

    2014-01-01

    Full Text Available Background. HIV patients on highly active antiretroviral therapy (HAART containing protease inhibitors (PIs had been often associated with lipodystrophy. However, there are only few studies on association of nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTI and NNRTI with lipodystrophy. Study Design. One hundred and one HIV male patients were categorised into ART naïve (n=22, zidovudine (n=22, stavudine (n=18, tenofovir (n=15, and PIs (n=24 based HAART. Their clinicoepidemiological data had been entered in preformed pro forma. The body composition, using TANITA machine and metabolic parameters like lipid profile, blood sugars was analysed. Results. Clinically, lipoatrophy of face was most prevalent in HIV patients on stavudine (15 patients, 83.3% and PIs (20 patients, 83.3% based HAART. The mean BMI among study population was in normal range. Excess visceral fat was most prevalent among patients on PIs, 4 patients (16.7%. The waist-hip ratio was significantly higher in PIs (P=0.01 based HAART. There was no significant difference among different study populations in terms of BMI (P=0.917, body water (P=0.318, body fat (P=0.172, bone mass (P=0.200, and muscle mass (P=0.070. Hypertriglyceridiemia was found in stavudine, tenofovir, and protease inhibitors regimens. Low levels of high density lipoprotein (HDL was found zidovudine, stavudine, and PIs regimens. Fasting and postprandial hyperglycaemia was found PIs and impaired glucose tolerance in stavudine regimen. Conclusion. Patients on PIs were associated with truncal obesity and lipoatrophy of face, along with dyslipidemia and hyperglycaemia. Stavudine based regimen is associated with hypertriglyceridiemia and low HDL along with lipoatrophy of face.

  19. Inadequacy of Body Weight-Based Recommendations for Individual Protein Intake—Lessons from Body Composition Analysis

    OpenAIRE

    Corinna Geisler; Prado, Carla M.; Müller, Manfred J.

    2016-01-01

    Current body weight-based protein recommendations are ignoring the large variability in body composition, particularly lean mass (LM), which drives protein requirements. We explored and highlighted the inter-individual variability of weight versus body composition-adjusted protein intakes by secondary analysis in three cohorts of (1) 574 healthy adults (mean ± SD age: 41.4 ± 15.2 years); (2) 403 cirrhotic patients (age: 44.7 ± 12.3 years) and (3) 547 patients with lung cancer (age: 61.3 ± 8.2...

  20. Functional body composition and related aspects in research on obesity and cachexia

    DEFF Research Database (Denmark)

    Müller, M J; Baracos, V; Bosy-Westphal, A;

    2014-01-01

    The 12th Stock Conference addressed body composition and related functions in two extreme situations, obesity and cancer cachexia. The concept of 'functional body composition' integrates body components into regulatory systems relating the mass of organs and tissues to corresponding in vivo...... and tissues mediated by cytokines, hormones and metabolites that are coupled with changes in body weight, composition and function as observed in obesity and cancer cachexia. In addition to established roles in intermediary metabolism, cell function and inflammation, organ-tissue crosstalk mediators...... are determinants of body composition and its change with weight gain and loss. The 12th Stock Conference supported Michael Stocks' concept of gaining new insights by integrating research ideas from obesity and cancer cachexia. The conference presentations provide an in-depth understanding of body composition...

  1. Natural Honey and Cardiovascular Risk Factors; Effects on Blood Glucose, Cholesterol, Triacylglycerole, CRP, and Body Weight Compared with Sucrose

    Directory of Open Access Journals (Sweden)

    N. Yaghoobi

    2008-01-01

    Full Text Available It has been found that honey ameliorates cardiovascular risk factors in healthy individuals and in patients with elevated risk factors. The present study investigated the effect of natural honey on total cholesterol, low-density lipoprotein cholesterol (LDL-C, high-density lipoprotein cholesterol (HDL-C, triacylglycerole, C-reactive protein (CRP, fasting blood glucose (FBG, and body weight in overweight individuals. There were 55 patients, overweight or obese, who were randomly recruited into the study and assigned into two groups: control group (17 subjects and experimental group (38 subjects. Patients in the control group received 70 g of sucrose daily for a maximum of 30 days and patients in the experimental group received 70 g of natural honey for the same period. In the control and experimental groups, body weight, body mass index, body fat weight, total cholesterol, LDL-C, HDL-C, triacylglycerole, FBG, and CRP were measured before treatment and at day 31 after the commencement of treatment. Results showed that honey caused a mild reduction in body weight (1.3% and body fat (1.1%. Honey reduced total cholesterol (3%, LDL-C (5.8, triacylglycerole (11%, FBG (4.2%, and CRP (3.2%, and increased HDL-C (3.3% in subjects with normal values, while in patients with elevated variables, honey caused reduction in total cholesterol by 3.3%, LDL-C by 4.3%, triacylglycerole by 19%, and CRP by 3.3% (p < 0.05. It is our conclusion that consumption of natural honey reduces cardiovascular risk factors, particularly in subjects with elevated risk factors, and it does not increase body weight in overweight or obese subjects.

  2. Influence of Body Composition on Gait Kinetics throughout Pregnancy and Postpartum Period

    Science.gov (United States)

    Branco, Marco; Santos-Rocha, Rita; Vieira, Filomena; Silva, Maria-Raquel; Aguiar, Liliana; Veloso, António P.

    2016-01-01

    Pregnancy leads to several changes in body composition and morphology of women. It is not clear whether the biomechanical changes occurring in this period are due exclusively to body composition and size or to other physiological factors. The purpose was to quantify the morphology and body composition of women throughout pregnancy and in the postpartum period and identify the contribution of these parameters on the lower limb joints kinetic during gait. Eleven women were assessed longitudinally, regarding anthropometric, body composition, and kinetic parameters of gait. Body composition and body dimensions showed a significant increase during pregnancy and a decrease in the postpartum period. In the postpartum period, body composition was similar to the 1st trimester, except for triceps skinfold, total calf area, and body mass index, with higher results than at the beginning of pregnancy. Regression models were developed to predict women's internal loading through anthropometric variables. Four models include variables associated with the amount of fat; four models include variables related to overall body weight; three models include fat-free mass; one model includes the shape of the trunk as a predictor variable. Changes in maternal body composition and morphology largely determine kinetic dynamics of the joints in pregnant women. PMID:27073713

  3. Influence of Body Composition on Gait Kinetics throughout Pregnancy and Postpartum Period.

    Science.gov (United States)

    Branco, Marco; Santos-Rocha, Rita; Vieira, Filomena; Silva, Maria-Raquel; Aguiar, Liliana; Veloso, António P

    2016-01-01

    Pregnancy leads to several changes in body composition and morphology of women. It is not clear whether the biomechanical changes occurring in this period are due exclusively to body composition and size or to other physiological factors. The purpose was to quantify the morphology and body composition of women throughout pregnancy and in the postpartum period and identify the contribution of these parameters on the lower limb joints kinetic during gait. Eleven women were assessed longitudinally, regarding anthropometric, body composition, and kinetic parameters of gait. Body composition and body dimensions showed a significant increase during pregnancy and a decrease in the postpartum period. In the postpartum period, body composition was similar to the 1st trimester, except for triceps skinfold, total calf area, and body mass index, with higher results than at the beginning of pregnancy. Regression models were developed to predict women's internal loading through anthropometric variables. Four models include variables associated with the amount of fat; four models include variables related to overall body weight; three models include fat-free mass; one model includes the shape of the trunk as a predictor variable. Changes in maternal body composition and morphology largely determine kinetic dynamics of the joints in pregnant women.

  4. Chemical composition and electronic structure of the passive layer formed on stainless steels in a glucose-oxidase solution

    Energy Technology Data Exchange (ETDEWEB)

    Marconnet, C. [Laboratoire de Genie des Procedes et des Materiaux, Ecole Centrale Paris, Grande Voie des Vignes, 92290 CHATENAY-MALABRY (France)], E-mail: cyril.marconnet@yahoo.fr; Wouters, Y. [Science et Ingenierie des Materiaux et Procedes, Institut National Polytechnique de Grenoble, F-38402 Saint-Martin d' Heres Cedex (France); Miserque, F. [Laboratoire de Reactivite des Surfaces et des Interfaces, CEA Saclay, Bat. 391, 91191 GIF-SUR-YVETTE (France); Dagbert, C. [Laboratoire de Genie des Procedes et des Materiaux, Ecole Centrale Paris, Grande Voie des Vignes, 92290 CHATENAY-MALABRY (France)], E-mail: catherine.dagbert@ecp.fr; Petit, J.-P. [Laboratoire d' Electrochimie et de Physico-chimie des Materiaux et des Interfaces, INPG, F-38402 Saint-Martin d' Heres Cedex (France); Galerie, A. [Science et Ingenierie des Materiaux et Procedes, Institut National Polytechnique de Grenoble, F-38402 Saint-Martin d' Heres Cedex (France); Feron, D. [Service de Corrosion et du Comportement des Materiaux dans leur Environnement, CEA Saclay, Bat. 458, 91191 GIF-SUR-YVETTE (France)

    2008-12-01

    This article deals with the interaction between the passive layer formed on UNS S30403 and S31254 stainless steels and an enzymatic solution containing glucose oxidase (GOx) and its substrate D-glucose. This enzymatic solution is often used to reproduce in laboratory the ennoblement occuring in non-sterile aerated aqueous environments because of the biofilm settlement on the surface of the metallic material. GOx catalyses the oxidation of D-glucose to gluconic acid by reducing oxygen to hydrogen peroxide and produces an organic acid. Thanks to photocurrent measurements, XPS analysis and Mott-Schottky diagrams, it is here shown that such an environment generates modifications in the chemical composition and electronic structure of the passive layer: it induces a relative enrichment of the n-type semi-conducting phase containing chromium (chromine Cr{sub 2}O{sub 3}) and an increase of the donors density in the space charge region.

  5. Body composition from birth to 6 mo of age in Ethiopian infants

    DEFF Research Database (Denmark)

    Andersen, Gregers Stig; Girma, Tsinuel; Wells, Jonathan C;

    2013-01-01

    Data on body composition in infancy may improve the understanding of the relation between variability in fetal and infant growth and disease risk through the life course. Although new assessment techniques have recently become available, body composition is rarely described in infants from low-in...

  6. Total and regional body-composition changes in early postmenopausal women

    DEFF Research Database (Denmark)

    Wang, Q; Hassager, C; Ravn, Pernille;

    1994-01-01

    Total and regional body composition were measured in 373 early postmenopausal women aged 49-60 y by dual-energy x-ray absorptiometry to evaluate whether the changes in body composition in the early postmenopausal years are related to menopause itself or merely to age. Both fat mass and fat...

  7. Ultrasound use for body composition and carcass quality assessment in cattle and lambs

    Science.gov (United States)

    Genetic evaluation for carcass quality traits has evolved over time, in large part due to introduction of new technology such as ultrasound measures of body composition. Ultrasound measured body composition traits emulate important carcass traits, are very informative for selection purposes, are ac...

  8. Comparison of body composition in persons with epilepsy on conventional & new antiepileptic drugs

    Directory of Open Access Journals (Sweden)

    Sudhir Chandra Sarangi

    2016-01-01

    Interpretation & conclusions: The alterations observed in body composition with valproic acid in contrast to other AEDs like levetiracetam, carbamazepine and phenytoin could affect treatment response in epilepsy especially in subjects with already altered body composition status like obese and thin frail patients, which needs to be established by prospective studies (CTRI/2013/05/003701.

  9. Effects of neutering on food intake, body weight and body composition in growing female kittens.

    Science.gov (United States)

    Alexander, Lucille G; Salt, Carina; Thomas, Gaelle; Butterwick, Richard

    2011-10-01

    To understand the effects of neutering on food intake, body weight (BW) and body composition in kittens, data from an unrelated study were subjected to post hoc analysis. A total of twelve pairs of 11-week-old female littermates were randomly assigned to either a neutered group (neutered at 19 weeks old) or an entire group (kept entire) and offered free access to a dry diet until the age of 1 year. Neutered kittens exhibited increased food intake and increased BW after neutering (both P kittens was 17 (95 % CI 8, 27) % more than entire littermates (P = 0.00 014). The intake was then reduced until there was no significant difference between the groups 18 weeks post-neutering. By 52 weeks of age, the neutered kittens were 24 (95 % CI 11, 39) % heavier than entire littermates (P kittens continued to grow significantly fatter after neutering (all P kittens showed no significant change after 18 weeks of age. As neutered kittens consumed similar amounts of energy to their entire littermates from 18 weeks post-neutering, while their BW, BCS and percentage fat continued to increase, we suggest that neutered kittens have a reduced metabolisable energy requirement, and should therefore be fed to maintain an ideal BCS rather than ad libitum. Moreover, to maintain an ideal BCS, entire kittens consumed 93 (95 % CI 87, 100) % of their theoretical intake at 26 weeks of age, and 79 (95 % CI 72, 87) % at 52 weeks of age, suggesting that the current energy recommendation is inappropriate for these kittens.

  10. Assessment of nutritional status in cancer--the relationship between body composition and pharmacokinetics.

    Science.gov (United States)

    Prado, Carla M M; Maia, Yara L M; Ormsbee, Michael; Sawyer, Michael B; Baracos, Vickie E

    2013-10-01

    Several nutritional assessment tools have been used in oncology settings to monitor nutritional status and its associated prognostic significance. Body composition is fundamental for the assessment of nutritional status. Recently, the use of accurate and precise body composition tools has significantly added to the value of nutritional assessment in this clinical setting. Computerized tomography (CT) is an example of a technique which provides state-of-the-art assessment of body composition. With use of CT images, a great variability in body composition of cancer patients has been identified even in people with identical body weight or body mass index. Severe muscle depletion (sarcopenia) has emerged as a prevalent body composition phenotype which is predictive of poor functional status, shorter time to tumor progression, shorter survival, and higher incidence of dose-limiting toxicity. Variability in body composition of cancer patients may be a source of disparities in the metabolism of cytotoxic agents. Future clinical trials investigating dose reductions in patients with sarcopenia and dose-escalating studies based on pre-treatment body composition assessment have the potential to alter cancer treatment paradigms.

  11. Endothelial cell and platelet bioenergetics: effect of glucose and nutrient composition.

    Directory of Open Access Journals (Sweden)

    Brian D Fink

    Full Text Available It has been suggested that cells that are independent of insulin for glucose uptake, when exposed to high glucose or other nutrient concentrations, manifest enhanced mitochondrial substrate oxidation with consequent enhanced potential and generation of reactive oxygen species (ROS; a paradigm that could predispose to vascular complications of diabetes. Here we exposed bovine aortic endothelial (BAE cells and human platelets to variable glucose and fatty acid concentrations. We then examined oxygen consumption and acidification rates using recently available technology in the form of an extracellular oxygen and proton flux analyzer. Acute or overnight exposure of confluent BAE cells to glucose concentrations from 5.5 to 25 mM did not enhance or change the rate of oxygen consumption (OCR under basal conditions, during ATP synthesis, or under uncoupled conditions. Glucose also did not alter OCR in sub-confluent cells, in cells exposed to low serum, or in cells treated with added pyruvate. Likewise, overnight exposure to fatty acids of varying saturation had no such effects. Overnight exposure of BAE cells to low glucose concentration decreased maximal uncoupled respiration, but not basal or ATP related oxygen consumption. Labeled glucose oxidation to CO(2 increased, but only marginally after high glucose exposure while oleate oxidation to CO(2 decreased. Overnight exposure to linolenic acid, but not oleic or linoleic acid increased extracellular acidification consistent with enhanced glycolytic metabolism. We were unable to detect an increase in production of reactive oxygen species (ROS from BAE cells exposed to high medium glucose. Like BAE cells, exposure of human platelets to glucose did not increase oxygen consumption. As opposed to BAE cells, platelet mitochondria demonstrate less respiratory reserve capacity (beyond that needed for basal metabolism. Our data do not support the concept that exposure to high glucose or fatty acids accelerates

  12. School-based exercise improves fitness, body composition, insulin sensitivity, and markers of inflammation in non-obese children.

    Science.gov (United States)

    Carrel, Aaron L; McVean, Jennifer J; Clark, R Randall; Peterson, Susan E; Eickhoff, Jens C; Allen, David B

    2009-05-01

    Poor cardiovascular fitness (CVF) is a risk factor for obesity, as well as insulin resistance (IR), inflammation, and cardiovascular disease. We have previously shown that a school-based fitness curriculum can improve CVF, as well as IR and body composition in obese children. Whether such a program improves CVF, IR, and other health indicators in non-obese children is unresolved. To determine whether a school-based fitness program improves body composition, CVF, markers of inflammation (e.g. CRP, TNF-alpha, adiponectin), and insulin sensitivity in nonobese children. 35 non-obese middle school children with body mass index below the 95th percentile for age were enrolled in a 'fitness-oriented' gym class. Children underwent fasting evaluation of insulin, glucose, adiponectin, CRP, TNF-alpha, body composition by dual X-ray absorptiometry (DXA), and maximal VO2 treadmill testing at baseline (prior to the school year) and again at end of the school year. Testing for CVF (maximal VO2 treadmill testing), DXA, and fasting evaluation of insulin, glucose, adiponectin, CRP and TNF-alpha. Children demonstrated a decrease in BMI z-score (-0.14 +/- 0.33, p = 0.02), HOMA-IR (-0.15 +/- 0.35, p = 0.016), and TNF-alpha (-2.55 +/- 1.79 pg/ml, p VO2(max) (+1.58 +/- 2.34 ml/kg/min, p < 0.001), adiponectin (+7,553 +/- 11,100 ng/ml, p < 0.001), and muscle mass (+2,282 +/- 1,882.73 g, p < 0.001) after nine months of study. The school-based fitness oriented curriculum resulted in improved body composition and insulin sensitivity, increased CVF, and decreased inflammation in non-obese children. Combined with prior studies, these data demonstrate that school-based fitness curricula can benefit both obese and non-obese children. Partnerships with schools to promote fitness should be part of a public health approach to improving children's health.

  13. Medical weight loss versus bariatric surgery: does method affect body composition and weight maintenance after 15% reduction in body weight?

    Science.gov (United States)

    Kulovitz, Michelle G; Kolkmeyer, Deborah; Conn, Carole A; Cohen, Deborah A; Ferraro, Robert T

    2014-01-01

    The aim of this study was to investigate body composition changes in fat mass (FM) to lean body mass (LBM) ratios following 15% body weight loss (WL) in both integrated medical treatment and bariatric surgery groups. Obese patients (body mass index [BMI] 46.6 ± 6.5 kg/m(2)) who underwent laparoscopic gastric bypass surgery (BS), were matched with 24 patients undergoing integrated medical and behavioral treatment (MT). The BS and MT groups were evaluated for body weight, BMI, body composition, and waist circumference (WC) at baseline and after 15% WL. Following 15% body WL, there were significant decreases in %FM and increased %LBM (P loss during the first 15% reduction in body weight. Finally, no significant differences (P = 0.103) between groups for maintenance of WL at 1 y were found. For both groups, baseline FM was found to be negatively correlated with percentage of weight regained (%WR) at 1 y post-WL (r = -0.457; P = 0.007). Baseline WC and rate of WL to 15% were significant predictors of %WR only in the BS group (r = 0.713; P = 0.020). If followed closely by professionals during the first 15% body WL, patients losing 15% weight by either medical or surgical treatments can attain similar FM:LBM loss ratios and can maintain WL for 1 y. Copyright © 2014 Elsevier Inc. All rights reserved.

  14. Influence of age, menopause status, body mass index and physical activity on body composition and body fat distribution in midlife women

    Institute of Scientific and Technical Information of China (English)

    Wei Dai-min; Yu Qi; Zhang Ying; Chen Feng-ling

    2012-01-01

    Objective: To investigate the influence of age,menopause status,body mass index (BMI) and physical activity on body composition and body fat distribution in Chinese midlife women.Methods: The healthy women who underwent anniversary health checkup in Peking Union Medical College Hospital were recruited cross-sectionally.The level of physical activity was determined via International Physical Activity Questionnaire-Short in Chinese Version.The body composition and fat distribution were measured by dualenergy X-ray absorptiometry.Results: A total of 162 women with average age 52 years (40-62 years) were recruited.Multivariate linear regression analysis was performed to test the relationship between age,menopause status,BMI and physical activity and parameters of body composition and body fat distribution.The total fat tissue percentage was positively associated with BMI (standardized partial regression coefficient: b=0.70),menopause status (b=0.19,grading variables 1,2,3 were assigned to represent for reproductive group,menopausal transition group and postmenopausal group,respectively),and negatively associated with physical activity energy expenditure (b=-0.17) with model determination coefficient 0.55.Total body fat-free-tissue mass was positively associated with BMI (b =0.61),negatively associated with menopause status (b =-0.14) with model determination coefficient 0.39.The ratio of trunk fat-tissue mass/total body fat-tissue mass (Tr/T) was positively associated with BMI (b=0.32) and menopause status (b= 0.30) with model determination coefficient 0.20.After adjusted the effects of BMI,menopause status and physical activity,age was not significantly related with total fat tissue percentage,body fat-free-tissue mass,nor ratio of (Tr/T).Conclusion: Menopause impacts body composition and body fat distribution independently.During the process of female reproductive aging,body fat tissue mass and centrally distributed fat tissue mass increase,while body fatfree

  15. The Association of Omentin Levels in Non-Diabetic Postmenopausal Women with Bone Mineral Density and Total Body Composition

    Directory of Open Access Journals (Sweden)

    Tulay Ozlu

    2015-05-01

    Full Text Available Objectives: Positive relation between body mass and bone mineral density (BMD is thought to be due to weight bearing effect. However, adipose tissue derived adipokines may have important effects on bone. Obese women have decreased levels of omentin in circulation which is related with adverse metabolic events. The hypothesis was that performed in this study, we aimed to study the association of omentin levels with body composition and BMD in non-diabetic postmenopausal women.Methods: Postmenopausal women aged 40 to 70 years, scheduled for BMD testing were prospectively evaluated. Patients with known diabetes, chronic renal failure, chronic liver disease, malabsorption, inflammatory bowel disease, <40 and >70 years of age were excluded. BMD and body composition were measured by DXA (GE-Lunar DPX pro. Fasting blood samples were obtained for analysis of complete blood count, glucose, creatinine, lipid profile and omentin. Statistical analyses were performed by using SPSS version 18 for windows. P<0.05 was considered statistically significant.   Results: Mean age of the patients in the osteoporosis group was higher than that of the control group (59.1±7.6 vs 53.3±5.7, p<0.05. Mean omentin level was higher in osteoporosis group than in osteopenia and control groups (479.7±141.6 vs 342.3±173.6 and 346.8±127.2, p<0.05. Total body fat mass, muscle mass and the T score of lumbar spine had a negative correlation with omentin levels (r=-0.252, -0.276, -0.344, p<0.05.Conclusions: Body composition does not seem to effect omentin levels. Women with a lower BMI have increased omentin levels. Higher omentin levels are associated with lower T scores at the lumbar spine.

  16. The effects of coconut oil supplementation on the body composition and lipid profile of rats submitted to physical exercise

    Directory of Open Access Journals (Sweden)

    NATHÁLIA M. RESENDE

    2016-06-01

    Full Text Available This study aims to verify the effects of coconut oil supplementation (COS in the body composition and lipid profile of rats submitted to physical exercise. The animals (n=6 per group were randomly assigned to: G1=Sedentary and Non-supplemented (Control Group, G2=Sedentary and Supplemented, G3=Exercised and Non-supplemented and G4=Exercised and Supplemented. The COS protocol used was 3 mL/Kg of body mass by gavage for 28 days. The physical exercise was the vertical jumping training for 28 days. It was determined the body mass parameters, Lee Index, blood glucose and lipid profile. The COS did not interfere with body mass, but the lean body mass was lower in G3 compared to G2. The final Lee Index classified G1 and G2 as obese (>30g/cm. The lipid profile showed total cholesterol was decreased in G3, LDL-c concentration was decreased in G2, triglycerides, VLDL-c and HDL-c concentrations were increased in G2 and G4 in relation to G1 and G3. The COS decreased LDL-c/HDL-c ratio. In conclusion, the COS associated or not to physical exercise worsen others lipid parameters, like triglycerides and VLDL-c level, showing the care with the use of lipid supplements.

  17. The effects of coconut oil supplementation on the body composition and lipid profile of rats submitted to physical exercise.

    Science.gov (United States)

    Resende, Nathália M; Félix, Henrique R; Soré, Murillo R; M M, Aníbal; Campos, Kleber E; Volpato, Gustavo T

    2016-05-13

    This study aims to verify the effects of coconut oil supplementation (COS) in the body composition and lipid profile of rats submitted to physical exercise. The animals (n=6 per group) were randomly assigned to: G1=Sedentary and Non-supplemented (Control Group), G2=Sedentary and Supplemented, G3=Exercised and Non-supplemented and G4=Exercised and Supplemented. The COS protocol used was 3 mL/Kg of body mass by gavage for 28 days. The physical exercise was the vertical jumping training for 28 days. It was determined the body mass parameters, Lee Index, blood glucose and lipid profile. The COS did not interfere with body mass, but the lean body mass was lower in G3 compared to G2. The final Lee Index classified G1 and G2 as obese (>30g/cm). The lipid profile showed total cholesterol was decreased in G3, LDL-c concentration was decreased in G2, triglycerides, VLDL-c and HDL-c concentrations were increased in G2 and G4 in relation to G1 and G3. The COS decreased LDL-c/HDL-c ratio. In conclusion, the COS associated or not to physical exercise worsen others lipid parameters, like triglycerides and VLDL-c level, showing the care with the use of lipid supplements.

  18. The Use Of Biostereometric Methods To Study Astronaut Body Composition

    Science.gov (United States)

    Whittle, M. W.

    1980-07-01

    Biostereometric analysis of body form was performed preflight and postflight on the 9 Skylab astronauts, using 4-camera stereophotogrammetry. The estimated standard deviation of the measurement of total body volume was 2-3%, but it should be possible to improve this to 1-2%, given some comparative studies with other methods, and some improvements in technique. The accuracy would then be comparable with underwater weighing, which is acknowledged to be the best currently available method for determining body density, and hence calculating body fat. Improvements beyond this accuracy are unlikely to lead to an enhancement in the accuracy of estimating body fat, because of uncertainties in the relationship between body fat and body density. Biostereometric analysis possesses one important advantage over underwater weighing, in that it is able to measure the volume of any chosen region of the body. This ability was used on Skylab to study the changes in leg muscle over the course of the flight, and also to measure the changes in body fat, which were particularly evident in the volume of the abdomen and buttocks. This approach would be greatly enhanced, however, by studies on the effects of diet and exercice on the volume of different body regions.

  19. Composite materials and bodies including silicon carbide and titanium diboride and methods of forming same

    Science.gov (United States)

    Lillo, Thomas M.; Chu, Henry S.; Harrison, William M.; Bailey, Derek

    2013-01-22

    Methods of forming composite materials include coating particles of titanium dioxide with a substance including boron (e.g., boron carbide) and a substance including carbon, and reacting the titanium dioxide with the substance including boron and the substance including carbon to form titanium diboride. The methods may be used to form ceramic composite bodies and materials, such as, for example, a ceramic composite body or material including silicon carbide and titanium diboride. Such bodies and materials may be used as armor bodies and armor materials. Such methods may include forming a green body and sintering the green body to a desirable final density. Green bodies formed in accordance with such methods may include particles comprising titanium dioxide and a coating at least partially covering exterior surfaces thereof, the coating comprising a substance including boron (e.g., boron carbide) and a substance including carbon.

  20. Body Composition Outcomes of a Qigong Intervention Among Community-Dwelling Aging Adults.

    Science.gov (United States)

    Chang, Mei-Ying; Chen, Hsiao-Yu

    2016-12-01

    Aging causes various changes in body composition, which are critical implications for health and physical functioning in aging adults. The aim of this study was to explore the body composition outcomes of a qigong intervention among community-dwelling aging adults. This was a quasi-experimental study in which 90 participants were recruited. Forty-eight participants (experimental group) attended a 30-min qigong program 3 times per week for 12 weeks, whereas 42 participants (control group) continued performing their usual daily activities. The experimental group achieved a greater reduction in the fat mass percentage at the posttest, and exhibited increased fat-free mass, lean body mass percentage, and lean body mass to fat mass ratio compared with the controls. No difference between the two groups in body mass index, fat mass, and lean body mass was observed. These results indicated that the qigong intervention showed beneficial outcomes of body composition among community-dwelling aging adults.

  1. Use of bioelectrical impedance analysis to assess body composition in rural Gambian children

    NARCIS (Netherlands)

    Prins, M.; Hawkesworth, S.; Wright, A.; Fulford, A.J.C.; Jarjou, L.M.A.; Prentice, A.M.; Moore, S.E.

    2008-01-01

    Objective: To validate the Tanita BC-418MA Segmental Body Composition Analyser and four-site skinfold measurements for the prediction of total body water (TBW), percentage fat-free mass (% FFM) and percentage body fat (%BF) in a population of rural Gambian children. Subjects/Methods: One hundred and

  2. Many-body problems with composite particles and q-Heisenberg algebras

    Energy Technology Data Exchange (ETDEWEB)

    Avancini, S.S. [Santa Catarina Univ., Florianopolis, SC (Brazil). Dept. de Fisica; Krein, G.

    1994-07-01

    It is proposed to employ deformed communication relations to treat many body problems of composite particles. The deformation parameter is interpreted as a measure of the effects of the statistics of the internal degrees of freedom of the composite particles. A simple application of the method is made for the case of a gas of composite bosons. (author). 14 refs.

  3. Impaired fasting glucose and body mass index as determinants of mortality in ALLHAT: is the obesity paradox real?

    Science.gov (United States)

    Shah, Ravi V; Abbasi, Siddique A; Yamal, José-Miguel; Davis, Barry R; Barzilay, Joshua; Einhorn, Paula T; Goldfine, Alison B; Goldfine, Allison

    2014-06-01

    Emerging literature suggests that obesity may be "protective" against mortality and cardiovascular outcomes, while dysglycemia may worsen outcomes regardless of obesity. The authors measured the association of weight, smoking, and glycemia with mortality in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Among 5423 ALLHAT participants without established diabetes or cardiovascular disease, 3980 (73%) had normal fasting glucose and 1443 (27%) had impaired fasting glucose (IFG) levels at study entry. After a median of 4.9 years follow-up, 554 (10%) had died (37% cardiovascular). IFG was associated with higher all-cause mortality (adjusted hazard ratio [HR], 1.23; 95% confidence interval [CI], 1.02-1.50), while obesity was associated with lower all-cause mortality (adjusted HR, 0.76; 95% CI, 0.60-0.96). However, after excluding underweight individuals (body mass index [BMI] obesity nor IFG was associated with all-cause mortality [corrected]. Although obesity appeared protective against mortality, this association was not significant in never-smokers or after exclusion of BMI obesity paradox may result from confounding by a sicker, underweight referent population and smoking.

  4. Breakfast, plasma glucose and beta-hydroxybutyrate, body mass index and academic performance in children from Extremadura, Spain.

    Science.gov (United States)

    Torres, M D; Carmona, I; Campillo, C; Pérez, G; Campillo, J E

    2007-01-01

    Nutritional aspects of breakfast, plasma levels of glucose and beta-hydroxybutyrate, body mass index and academic performance have been studied in urban and rural children (Extremadura, Spain). Representative samples of schoolchildren (3 to 12 years old, random cluster-sampling in schools). Children's mean caloric intake with breakfast was 331 kcal. Rural population ingested more carbohydrates (46,9 +/- 12,3% versus 43,3 +/- 13,2% of the total caloric intake) and fewer lipids (40,5 +/- 11,8% versus 43,9 +/- 12,8% of the total caloric intake) than the urban population. Academic performance was significantly better in the children inhabiting the rural zone than in those of the urban zone. The glycaemia was higher in the urban than in the rural children, and that the contrary was the case for the beta-hydroxybutyrate values. Neither glucose nor beta-hydroxybutyrate levels were correlated with academic performance values. BMI was significantly increased in the urban versus rural children. The present results emphasize the importance of breakfast and life style in the weight and the academic performance of children.

  5. The effect of normobaric hypoxic confinement on metabolism, gut hormones and body composition

    Directory of Open Access Journals (Sweden)

    Igor B. Mekjavic

    2016-06-01

    Full Text Available To assess the effect of normobaric hypoxia on metabolism, gut hormones and body composition, eleven normal weight, aerobically trained ( O2peak: 60.6±9.5 ml·kg-1·min-1 men (73.0±7.7 kg; 23.7±4.0 yrs, BMI 22.2±2.4 kg·m-2 were confined to a normobaric (altitude⋍940m normoxic (NORMOXIA; PIO2⋍133.2 mmHg or normobaric hypoxic (HYPOXIA; PIO was reduced from 105.6 to 97.7 mmHg over 10 days environment for 10 days in a randomized cross-over design. The wash-out period between confinements was 3 weeks. During each 10-day period, subjects avoided strenuous physical activity and were under continuous nutritional control. Before, and at the end of each exposure, subjects completed a meal tolerance test, during which blood glucose, insulin, GLP-1, ghrelin, peptide-YY, adrenaline, noradrenaline, leptin, and gastro-intestinal blood flow and appetite sensations were measured. There was no significant change in body weight in either of the confinements (NORMOXIA: -0.7±0.2 kg; HYPOXIA: -0.9±0.2 kg, but a significant increase in fat mass in NORMOXIA (0.23±0.45 kg, but not in HYPOXIA (0.08±0.08 kg. HYPOXIA confinement increased fasting noradrenaline and decreased energy intake, the latter most likely associated with increased fasting leptin. The majority of all other measured variables/responses were similar in NORMOXIA and HYPOXIA. To conclude, normobaric hypoxic confinement without exercise training results in negative energy balance due to primarily reduced energy intake.

  6. [Changes in body composition during an extreme endurance run].

    Science.gov (United States)

    Knechtle, B; Bircher, S

    2005-03-09

    We measured before, during and after a six-day-run in one athlete body weight, skinfold thickness, circumference of extremities, energy expenditure and nutritional intake. Despite an increased fat and protein intake during the race we found a significantly decrease in adipose subcutaneous tissue of the whole body and muscle mass in the active limbs whereas body weight remained stable. We presume that during running as eccentric exercise subcutaneous adipose tissue and muscle mass will be oxidised.

  7. [Human body composition during extended stay in microgravity].

    Science.gov (United States)

    Noskov, V B; Nichiporuk, I A; Vasilieva, G Yu; Smirnov, Yu I

    2015-01-01

    According to the Sprut-2 protocol, bio-impedancemetry of ISS cosmonauts was performed once a month and also before and after mission. Multiple non-invasive body measurements were carried out in 15 cosmonauts in real time. Relocation of extracellular liquid along the body axis led to its reduction in legs and, on the contrary, an increase in the abdomen. Volumes of total body liquid as well as intra- and extracellular liquids decreased in comparison with pre-flight levels. Lean body mass also became less in microgravity, whereas fat mass showed an increase.

  8. Early weaning impairs body composition in male mice

    Directory of Open Access Journals (Sweden)

    Maria Carolina Borges

    2009-12-01

    Full Text Available This study aimed to evaluate the effect of early weaning on body composition and on parameters related to nutritional status in mice. The experimental group consisted of male Swiss Webster mice that were weaned early (at postnatal day fourteen and fed an appropriate diet for growing rodents until postnatal day twenty-one (EW group. The control group consisted of male mice breastfed until postnatal day twenty-one (CON group. All animals were sacrificed on the twenty-first day of life. The EW group showed a decrease in liver and muscle protein content and concentration, brain protein concentration, brain DNA content and concentration, as well as liver and muscle protein/RNA ratio (pO presente estudo objetivou avaliar o efeito do desmame precoce sobre a composição corporal e sobre parâmetros indicativos do estado nutricional de camundongos. O grupo experimental consistiu de camundongos Swiss Webster, machos, desmamados precocemente (14º dia de vida e alimentados com ração apropriada para roedores em crescimento até o 21º dia pós-natal (grupo DESM. O grupo controle consistiu de camundongos amamentados até o 21º dia pós-natal (grupo CON. Todos os animais foram sacrificados no 21º dia de vida. O grupo DESM apresentou redução da concentração e conteúdo hepático e muscular de proteínas, da concentração cerebral de proteínas, da concentração e conteúdo cerebral de DNA e da razão proteína/RNA hepática e muscular (p<0,05. Quanto à composição corporal, o grupo DESM apresentou maior conteúdo de umidade, maior percentual de umidade e lipídios e menor conteúdo e percentual de cinzas e proteína na carcaça (p<0,05. Os resultados indicam que o desmame precoce acarreta em prejuízo à composição corporal e a parâmetros indicativos do estado nutricional, o que pode estar relacionado ao retardo do processo de maturação química. Os dados do presente estudo podem contribuir para o entendimento da influência da alimenta

  9. Tungsten oxide-Au nanosized film composites for glucose oxidation and sensing in neutral medium

    Directory of Open Access Journals (Sweden)

    Gougis M

    2015-04-01

    Full Text Available Maxime Gougis, Dongling Ma, Mohamed Mohamedi INRS-Énergie, Matériaux et Télécommunications, Varennes, Québec, Canada Abstract: In this work, we report for the first time the use of tungsten oxide (WOx as catalyst support for Au toward the direct electrooxidation of glucose. The nanostructured WOx/Au electrodes were synthesized by means of laser-ablation technique. Both micro-Raman spectroscopy and transmission electron microscopy showed that the produced WOx thin film is amorphous and made of ultrafine particles of subnanometer size. X-ray diffraction and X-ray photoelectron spectroscopy revealed that only metallic Au was present at the surface of the WOx/Au composite, suggesting that the WOx support did not alter the electronic structure of Au. The direct electrocatalytic oxidation of glucose in neutral medium such as phosphate buffered saline (pH 7.2 solution has been investigated with cyclic voltammetry, chronoamperometry, and square-wave voltammetry. Sensitivity as high as 65.7 µA cm-2 mM-1 up to 10 mM of glucose and a low detection limit of 10 µM were obtained with square-wave voltammetry. This interesting analytical performance makes the laser-fabricated WOx/Au electrode potentially promising for implantable glucose fuel cells and biomedical analysis as the evaluation of glucose concentration in biological fluids. Finally, owing to its unique capabilities proven in this work, it is anticipated that the laser-ablation technique will develop as a fabrication tool for chip miniature-sized sensors in the near future. Keywords: Au, tungsten oxide, nanostructures, pulsed laser deposition, glucose oxidation and sensing

  10. Analysis of the body composition of Paralympic athletes: Comparison of two methods.

    Science.gov (United States)

    Lemos, Valdir De Aquino; Alves, Eduardo Da Silva; Schwingel, Paulo Adriano; Rosa, João Paulo Pereira; Silva, Andressa Da; Winckler, Ciro; Vital, Roberto; De Almeida, Alexandre Aparecido; Tufik, Sergio; De Mello, Marco Túlio

    2016-11-01

    Body composition is a physiological variable associated with physical activity and, in some cases, is related to athletic performance. Our objectives were to describe the body composition of participants in three distinct Paralympic sports and to compare the values of body density and estimated body fat obtained from the Paralympic athletes on the National Team by air-displacement plethysmography (ADP) and by the anthropometric method (skinfolds (SFs)). The sample consisted of 70 volunteers of both genders. The body composition of the volunteers was evaluated using the ADP in a Bod Pod(®) and seven SFs. There were no significant differences between the values obtained by ADP and SF for body fat percentage (p = .58) and body density (p = .49). Analysis by Bland-Altman plots showed mean differences of 0.56 ± 4.94 (-9.12-10.23) and -0.0017 ± 0.0113 (-0.024-0.020) for body fat percentage and body density, respectively. In conclusion, body composition analyses of Paralympic athletes by the ADP and SF methods show similar results, and ADP should be used as the first option when available. When the use of ADP is not possible, estimating body density and fat percentage by SF is a viable alternative for Paralympic athletes when future comparisons will use the same analysis method.

  11. Association of Waist Circumference and Body Fat Weight with Insulin Resistance in Male Subjects with Normal Body Mass Index and Normal Glucose Tolerance.

    Science.gov (United States)

    Sasaki, Ryoma; Yano, Yutaka; Yasuma, Taro; Onishi, Yuki; Suzuki, Toshinari; Maruyama-Furuta, Noriko; Gabazza, Esteban C; Sumida, Yasuhiro; Takei, Yoshiyuki

    2016-01-01

    Objective We investigated the relationship of the waist circumference (WC) and body fat weight (BF) with insulin resistance in subjects with normal body mass index (BMI) and normal glucose tolerance (NGT) during a routine medical check-up. Methods We categorized 167 male subjects in three groups as follows: a group with normal BMI but high WC (normal-BMI/high-WC group; 22≤BMIBMI and normal WC (normal-BMI/normal-WC group, waist BMI and normal WC (low normal-BMI/normal-WC group; 18.5≤BMIBMI/high-WC group showed significantly decreased Matsuda index and increased homeostasis model assessment for insulin resistance (HOMA-IR) compared with normal-BMI/normal-WC group. Univariate regression analyses showed significant correlation of HOMA-IR with WC (r=0.39) and BF (r=0.37). Matsuda index was significantly correlated with WC (r=-0.39) and BF (r=-0.47). The multiple regression analysis showed that the BF is significantly correlated with HOMA-IR (pBMI/high-WC group. Multivariate analysis showed that BF is associated with decreased Matsuda index and increased HOMA-IR and that WC is not associated with either factors.

  12. SH2B1 regulation of energy balance, body weight, and glucose metabolism

    Institute of Scientific and Technical Information of China (English)

    Liangyou; Rui

    2014-01-01

    The Src homology 2B(SH2B)family members(SH2B1,SH2B2 and SH2B3)are adaptor signaling proteins containing characteristic SH2 and PH domains.SH2B1(also called SH2-B and PSM)and SH2B2(also called APS)are able to form homo-or hetero-dimers via their N-terminal dimerization domains.Their C-terminal SH2 domains bind to tyrosyl phosphorylated proteins,including Janus kinase 2(JAK2),TrkA,insulin receptors,insulin-like growth factor-1 receptors,insulin receptor substrate-1(IRS1),and IRS2.SH2B1 enhances leptin signaling by both stimulating JAK2 activity and assembling a JAK2/IRS1/2 signaling complex.SH2B1 promotes insulin signaling by both enhancing insulin receptor catalytic activity and protecting against dephosphorylation of IRS proteins.Accordingly,genetic deletion of SH2B1 results in severe leptin resistance,insulin resistance,hyperphagia,obesity,and type 2 diabetes in mice.Neuronspecific overexpression of SH2B1βtransgenes protects against diet-induced obesity and insulin resistance.SH2B1 in pancreaticβcells promotesβcell expansion and insulin secretion to counteract insulin resistance in obesity.Moreover,numerous SH2B1 mutations are genetically linked to leptin resistance,insulin resistance,obesity,and type 2 diabetes in humans.Unlike SH2B1,SH2B2 and SH2B3 are not required for the maintenance of normal energy and glucose homeostasis.The metabolic function of the SH2B family is conserved from insects to humans.

  13. Assessment of body composition by air-displacement plethysmography: influence of body temperature and moisture.

    Science.gov (United States)

    Fields, David A; Higgins, Paul B; Hunter, Gary R

    2004-04-01

    BACKGROUND: To investigate the effect of body temperature and moisture on body fat (%fat), volume and density by air-displacement plethysmography (BOD POD). METHODS: %fat, body volume and density by the BOD POD before (BOD PODBH) and immediately following hydrostatic weighing (BOD PODFH) were performed in 32 healthy females (age (yr) 33 +/- 11, weight (kg) 64 +/- 14, height (cm) 167 +/- 7). Body temperature and moisture were measured prior to BOD PODBH and prior to BOD PODFH with body moisture defined as the difference in body weight (kg) between the BOD PODBH and BOD PODFH measurements. RESULTS: BOD PODFH %fat (27.1%) and body volume (61.5 L) were significantly lower (P BOD PODBH %fat (28.9%), body volume (61.7 L), and body density (1.0341 g/cm3). A significant increase in body temperature (~0.6 degrees C; P BOD PODBH and BOD PODFH. Body surface area was positively associated with the difference in %fat independent of changes in body temperature and moisture, r = 0.30, P BOD POD, however, the precise mechanism remains unidentified.

  14. Association of vitamin K status with adiponectin and body composition in healthy subjects: uncarboxylated osteocalcin is not associated with fat mass and body weight.

    Science.gov (United States)

    Knapen, Marjo H J; Schurgers, Leon J; Shearer, Martin J; Newman, Paul; Theuwissen, Elke; Vermeer, Cees

    2012-09-28

    Osteocalcin (OC) is a vitamin K-dependent protein found in bone and in circulation. High serum γ-carboxylated OC reflects a high, and high uncarboxylated OC (ucOC) reflects a low vitamin K status. A revolutionary hypothesis is that ucOC acts as a hormone improving glucose handling and reducing fat mass. The objective was to test the logical extrapolation of the ucOC hormone hypothesis to humans that elevated ucOC is associated with higher body weight, BMI and fat mass. In a cross-sectional analysis, the associations of vitamin K status with circulating adiponectin and body composition were investigated in 244 postmenopausal women (study I). The effects of vitamin K treatment on adiponectin, body weight and BMI were investigated in archived samples from forty-two young men and women who received varying doses of menaquinone-7 during 12 weeks (study II) and from a cohort of 164 postmenopausal women who participated in a 3-year placebo-controlled trial on 45 mg menaquinone-4 (MK-4) (study III). No association was found between vitamin K status and circulating adiponectin before or after vitamin K supplementation. A higher carboxylation of OC was significantly correlated with lower body weight, BMI and fat mass of the trunk. Women taking MK-4 maintained their baseline body weight and BMI, whereas women taking placebo showed significant increases in both indices. These findings demonstrate that a high vitamin K status of bone has no effect on circulating adiponectin in healthy people and long-term vitamin K supplementation does not increase weight in healthy postmenopausal women.

  15. Sequential changes of body composition in patients with enterocutaneous fistula during the 10 days after admission

    Institute of Scientific and Technical Information of China (English)

    Xin-Bo Wang; Jian-An Ren; Jie-Shou Li

    2002-01-01

    AIM: To investigate the sequential changes of body composition in the metabolic response that occurred in a group of patients with enterocutaneous fistula after admission to the hospital.METHODS: Sixty-one patients with enterocutaneous fistula admitted to our hospital had measurements of body composition by multiple-frequency bioelectrical impedance analysis after admission and 5, 10 days later. Sequential measurements of plasma constitutive proteins were also made. RESULTS: The body weight, fat-free mass, body mass index, and body cell mass were initially well below the normal range, especially the body mass index and body cell mass. And all the data gradually moved up over the 10-day study period, only a highly significant difference was found in body cell mass. Once the patients Received nutrition supplement, ECW began to return to normal range slowly as well as ICW and TBW began to rise up, and ECW/TBW significantly declined to near normal level by day 10 in either male or female patients. There was a reprioritization of plasma constitutive protein synthesis that was obligatory and independent of changes in FFM.CONCLUSION: Serial measurements can quantify the disturbance of body composition in enterocutaneous fistula patients. The early nutritional intervention rapidly ameliorates the abnormal distribution of body water while the state-of-the-art surgical management prevents the further deterioration in cellular composition.

  16. Disposable Non-Enzymatic Glucose Sensors Using Screen-Printed Nickel/Carbon Composites on Indium Tin Oxide Electrodes

    Directory of Open Access Journals (Sweden)

    Won-Yong Jeon

    2015-12-01

    Full Text Available Disposable screen-printed nickel/carbon composites on indium tin oxide (ITO electrodes (DSPNCE were developed for the detection of glucose without enzymes. The DSPNCE were prepared by screen-printing the ITO substrate with a 50 wt% nickel/carbon composite, followed by curing at 400 °C for 30 min. The redox couple of Ni(OH2/NiOOH was deposited on the surface of the electrodes via cyclic voltammetry (CV, scanning from 0–1.5 V for 30 cycles in 0.1 M NaOH solution. The DSPNCE were characterized by field-emission scanning electron microscopy (FE-SEM, X-ray photoelectron spectroscopy (XPS, and electrochemical methods. The resulting electrical currents, measured by CV and chronoamperometry at 0.65 V vs. Ag/AgCl, showed a good linear response with glucose concentrations from 1.0–10 mM. Also, the prepared electrodes showed no interference from common physiologic interferents such as uric acid (UA or ascorbic acid (AA. Therefore, this approach allowed the development of a simple, disposable glucose biosensor.

  17. One-Pot Hydrothermal Synthesis of Magnetite Prussian Blue Nano-Composites and Their Application to Fabricate Glucose Biosensor

    Directory of Open Access Journals (Sweden)

    Ezzaldeen Younes Jomma

    2016-02-01

    Full Text Available In this work, we presented a simple method to synthesize magnetite Prussian blue nano-composites (Fe3O4-PB through one-pot hydrothermal process. Subsequently, the obtained nano-composites were used to fabricate a facile and effective glucose biosensor. The obtained nanoparticles were characterized using transmission electron microscopy, scanning electron microscopy, Fourier-transform infrared spectroscopy, UV-vis absorbance spectroscopy, cyclic voltammetry and chronoamperometry. The resultant Fe3O4-PB nanocomposites have magnetic properties which could easily controlled by an external magnetic field and the electro-catalysis of hydrogen peroxide. Thus, a glucose biosensor based on Fe3O4-PB was successfully fabricated. The biosensor showed super-electrochemical properties toward glucose detection exhibiting fast response time within 3 to 4 s, low detection limit of 0.5 µM and wide linear range from 5 µM to 1.2 mM with sensitivity of 32 µA∙mM−1∙cm−2 and good long-term stability.

  18. The effect of oxandrolone on body proportions and body composition in growth hormone-treated girls with Turner syndrome.

    NARCIS (Netherlands)

    Menke, L.A.; Sas, T.C.J.; Zandwijken, G.R.; Ridder, M.A. de; Stijnen, T.; Muinck Keizer-Schrama, S.M.P.F. de; Otten, B.J.; Wit, J.M.

    2010-01-01

    OBJECTIVE: Untreated girls with Turner syndrome (TS) have short stature, relatively broad shoulders, a broad pelvis, short legs, a high fat mass and low muscle mass. Our objective was to assess the effect of the weak androgen oxandrolone (Ox) on body proportions and composition in growth hormone (GH

  19. Body composition by a three compartment model in adult Indian male and female subjects.

    Science.gov (United States)

    Borgonha, S; Kuriyan, R; Shetty, P; Ferro-Luzzi, A; Kurpad, A V

    1997-07-01

    The body composition of 10 adult Indian male and female subjects was investigated by a three compartment model, using measurements of Total Body Water (TBW) by deuterium dilution, and of body density by hydrodensitometry. The three compartment model yielded significantly different (P hydrodensitometry, was 1.107+/-0.014 in the males and 1.101+/-0.001 in the females with no significant differences between the groups. This study demonstrates differences in body composition between BMI matched healthy adult male and female subjects. Although there are significant differences for % Fat and FFM between the sexes, there are no significant differences in the hydration fraction and the density of the FFM.

  20. Physiological responses of juvenile rainbow trout to fasting and swimming activity: Effects on body composition and condition indices

    Science.gov (United States)

    Simpkins, D.G.; Hubert, W.A.; Del Rio, C.M.; Rule, D.C.

    2003-01-01

    The physiological traits that allow fish to survive periods of limited food resources are poorly understood. We assessed changes in proximate body composition, relative organ mass, blood metabolites, and relative weight (Wr) of sedentary and actively swimming (15 cm/s) juvenile rainbow trout (154-182 mm total length) over 147 d of fasting. Fasting caused measurable responses that were augmented when fish were swimming. Lipids and plasma triacylglycerides declined over time. Proteins were catabolized simultaneously with lipid reserves, but ammonia concentrations in plasma did not increase. The liver somatic index (LSI) did not change substantially over 105 d, suggesting that gluconeogenesis maintained blood glucose concentrations and hepatic glycogen reserves for a substantial period of fasting. The gut somatic index (GSI) and Wr declined linearly during fasting, but the LSI did not decline until after 105 d of fasting. Consequently, the use of different body condition indices could lead to different conclusions about the condition of juvenile rainbow trout. Swimming activity caused fish to have lower lipid and protein reserves than those of sedentary fish. No mortalities were observed among sedentary fish, but mortalities occurred among actively swimming fish after 97 d of fasting when 3.2% or less lipid remained in their bodies. Body condition indices did not account for differences in proximate body composition between sedentary and actively swimming fish and were relatively poor predictors of lipid content and risk of mortality. The probability of mortality was most accurately predicted by percent lipid content. Therefore, we suggest that fisheries scientists consider using percent lipid content when evaluating the physiological status and risk of mortality due to starvation among juvenile rainbow trout.

  1. Measuring Body Composition in Individuals with Intellectual Disability: A Scoping Review

    Directory of Open Access Journals (Sweden)

    Amanda Faith Casey

    2013-01-01

    Full Text Available Background. Research shows obesity to be more prevalent amongst individuals with intellectual disability (ID making correct measurement of body composition crucial. This study reviewed the validity and reliability of methods used for assessing body composition in individuals with ID. Methods. Authors conducted electronic searches through PubMed (1990 to present and PsycINFO (1990 to present and assessed relevant articles independently based on scoping review guidelines. Reviewers included primary research related to the validity and reliability of body composition measures on individuals with ID. Results. Searches identified six articles assessing body composition methods used on individuals with ID including body mass index (BMI, skinfold thickness, bioelectrical impedance analysis (BIA, waist circumference, tibia length, and anthropometric girth measurements. BMI and waist circumference appear suitable measures but skinfold thickness measurements may not be advisable due to participants' noncompliance resulting in a lack of precision and inaccurate results. Conclusions. The current literature contains too few well-conducted studies to determine the precision and validity of body composition measures on individuals with ID. There may be a need to devise further regression equations that apply to individuals with specific types of ID in order to increase the reliability and validity of body composition measurements.

  2. Maternal flaxseed oil intake during lactation changes body fat, inflammatory markers and glucose homeostasis in the adult progeny: role of gender dimorphism.

    Science.gov (United States)

    Guarda, Deysla Sabino; de Moura, Egberto Gaspar; Carvalho, Janaíne Cavalcanti; Reis, Adelina Martha Dos; Soares, Patricia Novaes; Lisboa, Patricia Cristina; Figueiredo, Mariana Sarto

    2016-09-01

    We evaluated maternal flaxseed oil intake during lactation on body composition, lipid profile, glucose homeostasis and adipose tissue inflammation in male and female progeny at adulthood. Lactating rats were divided into the following: control 7% soybean oil (C), hyper 19% soybean oil (HS) and hyper 17% flaxseed oil+2% soybean oil (HF). Weaned pups received a standard diet. Offspring were killed in PN180. Male HF presented higher visceral adipose tissue (VAT) and triacylglycerol, and female HF showed insulin resistance. Both male and female HF had hyperleptinemia, and only male HF had hyperprolactinemia. In VAT, male HF presented lower PPAR-γ expressions and higher TNF-α, IL-6, IL-1β and IL-10 expressions; in subcutaneous adipose tissue (SAT), they presented lower PPAR-γ and TNF-α expressions. Female HF presented higher leptin, as well as lower adiponectin, TNF-α, IL-6 and IL-1β expressions in VAT and lower TNF-α in SAT. Flaxseed oil during lactation leads to gender-specific effects with more adiposity and dyslipidemia in male and insulin resistance in female. Higher prolactin and inflammatory cytokines in male could play a role in these gender differences. We suggest that the use of flaxseed oil during lactation increases metabolic syndrome risk in the adult progeny.

  3. Mediating effects of body composition between physical activity and body esteem in Hong Kong adolescents: a structural equation modeling approach.

    Science.gov (United States)

    Mak, Kwok-Kei; Cerin, Ester; McManus, Alison M; Lai, Ching-Man; Day, Jeffrey R; Ho, Sai-Yin

    2016-01-01

    This study investigated the mediating role of body mass index (BMI) in the relationship between physical activity and body esteem in adolescents. Nine hundred and five Hong Kong Chinese students aged 12-18 years participated in a cross-sectional study in 2007. Students' BMI was computed as an indicator of their body composition. Their physical activity level and body esteem were examined using the Physical Activity Rating for Children and Youth (PARCY) and Body Esteem Scale (BES), respectively. Structural equation modelling was used to investigate the mediating effects of BMI and physical activity in predicting body esteem, with stratification by sex. The overall fit of the hypothesized models was satisfactory in boys (NFI = 0.94; NNFI = 0.88; CFI = 0.95; RMSEA = 0.07) and girls (NFI = 0.89; NNFI = 0.77; CFI = 0.91; RMSEA = 0.11). When BMI was considered as a mediator, higher physical activity had a significant negative total effect on body esteem in boys, but not in girls. The indirect effect of higher physical activity on body esteem via BMI was positive in boys, but negative in girls. Regular physical activity may help overweight adolescents, especially boys, improve their body esteem. Kinesiologists and health professionals could explore the use of physical activity prescriptions for weight management, aiming at body esteem improvement in community health programs for adolescents. Among Western adolescents, negative body esteem is more pervasive in girls than in boys. There are consistent findings of the association between higher body mass index and lower body esteem in adolescents, but the association between physical activity and body esteem are equivocal. A negative association between body mass index and body esteem was found in both Hong Kong adolescent boys and girls. The indirect effect of physical activity on body esteem via body mass index was positive in Hong Kong adolescent boys, but negative in girls.

  4. The effect of Pilates exercise on body composition in sedentary overweight and obese women.

    Science.gov (United States)

    Şavkin, Raziye; Aslan, Ummuhan B

    2017-11-01

    Pilates is a popular exercise approach among women. Still there is poor empirical quantitative evidence indicating a positive effect of Pilates exercises on body composition. The aim of our study is to determine the effects of Pilates exercises on body composition in sedentary overweight and obese women. Thirty-seven women, aged between 30 to 50 (43.79±4.88) years, included the study. Subjects are randomly divided into Pilates group (N.=19) and control group (N.=18). Pilates exercises was given for 90 minutes, 3 times/week, for 8 week with a gradual strength increase of 11-17 in the Rating of Perceived Exercise. Control group did not participate in any physical activity program. Bioelectric Impedance Analysis was used for determine the body composition of participants. Weight, Body Mass Index (BMI), body fat mass, lean body mass, waist, abdomen and hip circumference were measured at pre- and post-training period. In Pilates group, weight, BMI, fat percentage, waist, abdomen and hip circumference decreased significantly after training (P0.05). In control group, abdomen and hip circumference increased significantly (PPilates exercises have positive effects on body composition in sedentary overweight and obese women. Pilates exercises can be applied for improving body composition.

  5. Supplementation with a fish protein hydrolysate (Micromesistius poutassou: effects on body weight, body composition, and CCK/GLP-1 secretion

    Directory of Open Access Journals (Sweden)

    Vincenzo Nobile

    2016-01-01

    Full Text Available Background: Fish protein hydrolysates (FPHs have been reported as a suitable source of proteins for human nutrition because of their balanced amino acid composition and positive effect on gastrointestinal absorption. Objective: Here, we investigated the effect of a FPH, Slimpro®, obtained from blue whiting (Micromesistius poutassou muscle by enzymatic hydrolysis, on body composition and on stimulating cholecystokinin (CCK and glucagon-like peptide-1 (GLP-1 secretion. Design: A randomized clinical study was carried out on 120, slightly overweight (25 kg/m2 ≤ BMI<30 kg/m2, male (25% and female (75% subjects. FPH was tested in a food supplement at two doses (1.4 and 2.8 g to establish if a dose–effect relationship exists. Product use was associated with a mild hypocaloric diet (−300 kcal/day. Body composition (body weight; fat mass; extracellular water; and circumference of waist, thighs, and hips and CCK/GLP-1 blood levels were measured at the beginning of the study and after 45 and 90 days of product use. CCK/GLP-1 levels were measured since they are involved in controlling food intake. Results: Treated subjects reported an improvement of body weight composition and an increased blood concentration of both CCK and GLP-1. No differences were found between the 1.4 and 2.8 g FPH doses, indicating a plateau effect starting from 1.4 g FPH. Conclusions: Both 1.4 and 2.8 g of FPH were effective in improving body composition and in increasing CCK and GLP-1 blood levels.

  6. Measurement of the glucose permeation rate across phospholipid bilayers using small unilamellar vesicles. Effect of membrane composition and temperature.

    Science.gov (United States)

    Bresseleers, G J; Goderis, H L; Tobback, P P

    1984-05-30

    Small unilamellar vesicles were used to measure the permeability of saturated phosphatidylcholine bilayers to glucose. The presented method circumvents most of the common restriction of classical permeability experiments. Increasing the fatty acid chain length of the lipids reduced the permeation rate significantly. Raising the temperature above that of the lipid phase transition drastically increased membrane permeability. Arrhenius plots demonstrated the activation energy to be independent of membrane composition and the phase-state of the lipids. The permeation process is discussed in terms of a constant energy to disrupt all hydrogen bonds between permeant and aqueous solvent prior to penetrating the membrane. The magnitude of the permeability coefficient is partly determined by a unfavourable change in entropy of activation on crossing the water/lipid interface. All results indicate that the penetration of the dehydrated permeant into the hydrophobic barrier is the rate-limiting step in the permeation of glucose.

  7. Whole body air displacement plethysmography compared with hydrodensitometry for body composition analysis

    National Research Council Canada - National Science Library

    Dewit, O; Fuller, N J; Fewtrell, M S; Elia, M; Wells, J C

    2000-01-01

    To assess the acceptability and feasibility of whole body air displacement plethysmography in children and to determine its precision and agreement with hydrodensitometry, an appropriate reference method...

  8. Body composition among Sri Lankan infants by 18*O dilution method and the validity of anthropometric equations to predict body fat against 18*O dilution

    Science.gov (United States)

    Body composition indicators provide a better guidance for growth and nutritional status of the infants. This study was designed to (1) measure the body composition of the Sri Lankan infants using a reference method, the 18*O dilution method; (2) calculate the body fat content of the infants using pu...

  9. Reaction mechanisms and kinetics of processing glucose, xylose and glucose-xylose mixtures under hot compressed water conditions for predicting bio-crude composition

    DEFF Research Database (Denmark)

    Grigoras, Ionela; Toor, Saqib Sohail; Rosendahl, Lasse Aistrup

    Mechanisms for bio-crude formation during the conversion of glucose, xylose and glucose-xylose mixtures as biomass model compounds under hot compressed water conditions are investigated. Studies in literature have shown that the diverse products formed at the early stages of glucose or xylose con...

  10. Body composition, fitness score and arterial stiffness assesment in a chronic hemodialysis population

    Directory of Open Access Journals (Sweden)

    Adelina Mihăescu

    2011-12-01

    Full Text Available Patients undergoing long-term hemodialysis have a high risk of cardiovascular disease. Arterial stiffness is highly prevalent in this type of patients. The aim of our study was to analyse the relationship between body composition, blood chemistries and arterial stiffness in a poorly fit population of chronic hemodialysed patients. Patients and methods involved measuring body composition and fitness score by multifrequence bioimpedance with the body composition analyzer InBody720 and arterial stiffness by the measurement of aortic Pulse Wave Velocity (PWVao and Aortic Augmentation Index (Aix using an oscillometric method on 65 HD patients; measurements were made before a midweek dialysis session. Results: PWVao correlated significantly with weight (p=0.01, r2=1.14, body fat mass (p=0.007, r2=0.14, abdominal circumference (p=0.01, r2=0.12 and with fitness score (p=0.01, r2=0.11. Aix correlated with weight (p<0.05, r2=0.25, intracellular, extracellular- and total body water (p<0.05, r2=0.24 with body protein, soft lean mass, minerals, fat free mass and skeletal muscle mass (p<0.05, r2= 0.3 and with serum calcium (p=0.005, r2=0.2. Conclusions: Arterial stiffness is a common feature of the hemodialysed patients, significantly related to the blood calcium, fitness score and the body composition, especially fat body mass.

  11. International symposium on in vivo body composition studies: Program and abstracts

    Energy Technology Data Exchange (ETDEWEB)

    1986-01-01

    This booklet contains the program and individual abstracts for papers presented at the International symposium on in vivo body composition studies. The presentations were divided into five sessions. Individual abstracts were indexed for the Energy Data Base. (DT)

  12. Feasibility and reliability of body composition measurements in adults with severe intellectual and sensory disabilities

    NARCIS (Netherlands)

    Waninge, A.; van der Weide, W.; Evenhuis, I. J.; van Wijck, R.; van der Schans, C. P.

    Anthropometric measurements are widely used to reliably quantify body composition and to estimate risks of overweight in healthy subjects and in patients. However, information about the reliability of anthropometric measurements in subjects with severe intellectual and sensory disabilities is

  13. Validation of bioelectrical-impedance analysis as a measurement of change in body composition in obesity

    Energy Technology Data Exchange (ETDEWEB)

    Kushner, R.F.; Kunigk, A.; Alspaugh, M.; Andronis, P.T.; Leitch, C.A.; Schoeller, D.A. (Univ. of Chicago, IL (USA))

    1990-08-01

    The bioelectrical-impedance-analysis (BIA) method accurately measures body composition in weight-stable subjects. This study validates the use of BIA to measure change in body composition. Twelve obese females underwent weight loss at a mean rate of 1.16 kg/wk. Body composition was measured by deuterium oxide dilution (D2O), BIA, and skinfold anthropometry (SFA) at baseline and at 5% decrements in weight. Highly significant correlations were obtained between D2O and BIA (r = 0.971) and between D2O and SFA (r = 0.932). Overall, BIA predicted change in fat-free mass with greater accuracy (to 0.4 kg) and precision (+/- 1.28 kg) than did anthropometry (to 0.8 kg and +/- 2.58 kg, respectively). We conclude that BIA is a useful clinical method for measuring change in body composition.

  14. Body Composition Monitor Assessing Malnutrition in the Hemodialysis Population Independently Predicts Mortality

    NARCIS (Netherlands)

    Rosenberger, Jaroslav; Kissova, Viera; Majernikova, Maria; Straussova, Zuzana; Boldizsar, Jan

    Objective: Malnutrition is a known predictor of mortality in the general and hemodialysis populations. However, diagnosing malnutrition in dialysis patients remains problematic. Body composition monitoring (BCM) is currently used mainly for assessing overhydratation in hemodialysis patients, but it

  15. Fitness knowledge, cardiorespiratory endurance and body composition of high school students

    Directory of Open Access Journals (Sweden)

    Williams Skip M.

    2013-11-01

    Full Text Available Study aim: The purpose of this study was to determine if high school physical education seniors’ health-related fitness knowledge is related to their aerobic capacity and body composition.

  16. iiv vito estimation of body composition in cattle with tritium and urea ...

    African Journals Online (AJOL)

    evaluate the tritium and urea dilution techniques for accurate predictron of body composition. Approximately l,l - 1 ..... assumed that the same principles would apply in the .... Automated and manual direct methods for the determination of blood ...

  17. Relationship between daily dietary fructose intake, body composition and biochemical parameters patients with type 2 diabetes

    Directory of Open Access Journals (Sweden)

    Sabriye Arslan

    2016-05-01

    Conclusion: Further studies are needed to develop more specific suggestions regarding fructose intake and to better understand the relationship between fructose intakes, body composition and biochemical parameters in individuals with type 2 diabetes.

  18. The effects of Ramadan fasting and physical activity on body composition and hematological biochemical parameters

    National Research Council Canada - National Science Library

    Seyyed Reza Attarzadeh Hosseini; Morteza Motahari Rad; Keyvan Hejazi

    2014-01-01

    .... This study aimed to have a closer look at fasting and regular physical activity and their impacts on body composition and blood hematological-biochemical parameters among professional wrestlers. Method...

  19. Body Composition Monitor Assessing Malnutrition in the Hemodialysis Population Independently Predicts Mortality

    NARCIS (Netherlands)

    Rosenberger, Jaroslav; Kissova, Viera; Majernikova, Maria; Straussova, Zuzana; Boldizsar, Jan

    2014-01-01

    Objective: Malnutrition is a known predictor of mortality in the general and hemodialysis populations. However, diagnosing malnutrition in dialysis patients remains problematic. Body composition monitoring (BCM) is currently used mainly for assessing overhydratation in hemodialysis patients, but it

  20. Body composition and reproduction in broiler breeders: impact of feeding strategies

    NARCIS (Netherlands)

    Emous, van R.A.

    2015-01-01

    ABSTRACT Key words: broiler breeder, feeding strategies, body composition, reproduction, behavior Nowadays, welfare issues in broiler breeders associated with nutrition and reproductive characteristics, are becoming increasingly challenging. Due to genetic selection on broilers,

  1. The effects of electrical stimulation on body composition and metabolic profile after spinal cord injury--Part II.

    Science.gov (United States)

    Gorgey, Ashraf S; Dolbow, David R; Dolbow, James D; Khalil, Refka K; Gater, David R

    2015-01-01

    Diet and exercise are cornerstones in the management of obesity and associated metabolic complications, including insulin resistance, type 2 diabetes, and disturbances in the lipid profile. However, the role of exercise in managing body composition adaptations and metabolic disorders after spinal cord injury (SCI) is not well established. The current review summarizes evidence about the efficacy of using neuromuscular electrical stimulation or functional electrical stimulation in exercising the paralytic lower extremities to improve body composition and metabolic profile after SCI. There are a number of trials that investigated the effects on muscle cross-sectional area, fat-free mass, and glucose/lipid metabolism. The duration of the intervention in these trials varied from 6 weeks to 24 months. Training frequency ranged from 2 to 5 days/week. Most studies documented significant increases in muscle size but no noticeable changes in adipose tissue. While increases in skeletal muscle size after twice weekly training were greater than those trials that used 3 or 5 days/week, other factors such as differences in the training mode, i.e. resistance versus cycling exercise and pattern of muscle activation may be responsible for this observation. Loading to evoke muscle hypertrophy is a key component in neuromuscular training after SCI. The overall effects on lean mass were modest and did not exceed 10% and the effects of training on trunk or pelvic muscles remain unestablished. Most studies reported improvement in glucose metabolism with the enhancement of insulin sensitivity being the major factor following training. The effect on lipid profile is unclear and warrants further investigation.

  2. Sarcopenia and body composition in diabetic Charcot osteoarthropathy

    DEFF Research Database (Denmark)

    Jansen, Rasmus Bo; Christensen, Tomas Møller; Bülow, Jens

    2015-01-01

    : Cross-sectional case-control study of people with diabetes with acute or chronic Charcot osteoarthropathy, matched with otherwise healthy people with diabetes. A total of 49 subjects (distribution ~1:1) had a total body DXA-scanning, measuring appendicular lean mass, android/gynoid and truncal...... (24.5-31.9%), whereas there were no significant differences found between the groups (P=0.065). Neither truncal/total fat percent nor android/gynoid fat percent ratios showed differences between the groups. CONCLUSION: To our knowledge, this is the first published dataset investigating body...

  3. Effects of a weight loss program on body composition and the metabolic profile in obese postmenopausal women displaying various obesity phenotypes: a MONET group study.

    Science.gov (United States)

    Normandin, Eve; Doucet, Eric; Rabasa-Lhoret, Rémi; Brochu, Martin

    2015-07-01

    Obesity is a heterogeneous condition, since the metabolic profile may differ greatly from one individual to another. The objective of this study was to compare the effect of a 6-month diet-induced weight loss program on body composition and the metabolic profile in obese individuals displaying different obesity phenotypes. Secondary analyses were done on 129 obese (% body fat: 46% ± 4%) postmenopausal women (age: 57 ± 4 years). Outcome measures included body composition, body fat distribution, glucose homeostasis, fasting lipids, and blood pressure. Obesity phenotypes were determined based on lean body mass (LBM) index (LBMI = LBM/height(2)) and visceral fat (VF) accumulation, as follows: 1, lower VF and lower LBMI (n = 35); 2, lower VF and higher LBMI (n = 19); 3, higher VF and lower LBMI (n = 14); and 4, higher VF and higher LBMI (n = 61). All groups had significantly improved measures of body composition after the intervention (P metabolic profile in response to weight loss. Individuals displaying higher VF or higher LBMI at baseline experienced significantly greater decreases for these variables after the intervention.

  4. Effect of Stress Conditions on Body Composition Parameters of Farmed Rohu (Labeo rohita)

    DEFF Research Database (Denmark)

    Shah, Syed Qaswar Ali; Hussain, Muhammad Zubair; Asif Ali, Muhammad

    2017-01-01

    Various stressors affect the body composition of fish. The current study was undertaken to investigate the effect of stress conditions on the body composition of farmed Labeo rohita. Sixty fingerlings were subjected to experimentation in aquaria after being acclimatized. The specimens were divided...... into control, starvation stress and double stress (pH 8 and starvation) groups with 20 individuals in each group. Fish samples for the estimation of body composition were taken after 12 days, 24 days, 36 days and 48 days. Standard procedures and protocols were used for analysis. There was a trend of gradual...... increase in ash contents (% dry body weight) in starvation and double stress group with increase in number of days. However, fat contents (% dry body weight) considerably decreased and protein contents remained unchanged. The inter-comparison of three groups showed that there was significant effect...

  5. Body image and correlation with body composition and attrition rate in the TIGER study

    Science.gov (United States)

    Body image can be a very important part of determining an individual's outlook and behavior. Previous research has shown that the degree of satisfaction women have with their bodies may vary across race and may have a significant impact on an individual's motivation and commitment to a regular exer...

  6. Associations between Body Composition, Hormonal and Lifestyle Factors, Bone Turnover, and BMD

    OpenAIRE

    Gourlay, Margaret L.; Hammett-Stabler, Catherine A; Renner, Jordan B.; Rubin, Janet E.

    2014-01-01

    Background The relative importance of body composition, lifestyle factors, bone turnover and hormonal factors in determining bone mineral density (BMD) is unknown. We studied younger postmenopausal women to determine whether modifiable or nonmodifiable risk factors for osteoporosis have stronger associations with BMD. Methods In multivariable linear regression models, we tested associations between non-bone body composition measures, self-reported measures of physical activity and dietary int...

  7. The effect of protein and glycemic index on children's body composition

    DEFF Research Database (Denmark)

    Papadaki, Angeliki; Linardakis, Manolis; Larsen, Thomas Meinert;

    2010-01-01

    To investigate the effect of protein and glycemic index (GI) on body composition among European children in the randomized, 6-month dietary intervention DiOGenes (diet, obesity, and genes) family-based study.......To investigate the effect of protein and glycemic index (GI) on body composition among European children in the randomized, 6-month dietary intervention DiOGenes (diet, obesity, and genes) family-based study....

  8. Adhesion molecules and chemokines: relation to anthropometric, body composition, biochemical and dietary variables

    OpenAIRE

    2014-01-01

    Introduction: Among the inflammatory mediators involved in the pathogenesis of obesity, the cell adhesion molecules P-selectin, E-selectin, VCAM-1, ICAM-1 and the chemokine MCP-1 stand out. They play a crucial role in adherence of cells to endothelial surfaces, in the integrity of the vascular wall and can be modulated by body composition and dietary pattern. Objectives: To describe and discuss the relation of these cell adhesion molecules and chemokines to anthropometric, body composition, d...

  9. Adhesion molecules and chemokines : relation to anthropometric, body composition, biochemical and dietary variables.

    OpenAIRE

    Vieira, Renata Adrielle Lima; Freitas,Renata Nascimento; Volp, Ana Carolina Pinheiro

    2014-01-01

    Introduction: Among the inflammatory mediators involved in the pathogenesis of obesity, the cell adhesion molecules Pselectin, E-selectin, VCAM-1, ICAM-1 and the chemokine MCP-1 stand out. They play a crucial role in adherence of cells to endothelial surfaces, in the integrity of the vascular wall and can be modulated by body composition and dietary pattern. Objectives: To describe and discuss the relation of these cell adhesion molecules and chemokines to anthropometric, body composition, di...

  10. Dual-energy X-ray absorptiometry body composition in patients with secondary osteoporosis.

    Science.gov (United States)

    Messina, Carmelo; Monaco, Cristian Giuseppe; Ulivieri, Fabio Massimo; Sardanelli, Francesco; Sconfienza, Luca Maria

    2016-08-01

    Due to the tight relationship between bone and soft tissues, there has been an increased interest in body composition assessment in patients with secondary osteoporosis as well as other pathological conditions. Dual-energy X-ray absorptiometry (DXA) is primarily devoted to the evaluation of bone mineral status, but continuous scientific advances of body composition software made DXA a rapid and easily available technique to assess body composition in terms of fat mass and lean mass. As a result, the International Society for Clinical Densitometry (ISCD) recently developed Official Positions regarding the use of this technique for body composition analysis. According to ISCD paper, indications are mainly limited to three conditions: HIV patients treated with antiretroviral agents associated with a risk of lipoatrophy; obese patients undergoing treatment for high weight loss; patients with sarcopenia or muscle weakness. Nevertheless, there are several other interesting clinical applications that were not included in the ISCD position paper, such as body composition assessment in patients undergoing organ transplantation, pulmonary disease as well as all those chronic condition that may lead to malnutrition. In conclusion, DXA body composition offers new diagnostic and research possibilities for a variety of diseases; due to its high reproducibility, DXA has also the potential to monitor body composition changes with pharmacological, nutritional or physic therapeutic interventions. ISCD addressed and recommended a list of clinical condition, but the crescent availability of DXA scans and software improvements may open the use of DXA to other indication in the next future. This article provides an overview of DXA body composition indications in the management of secondary osteoporosis and other clinical indications in adults.

  11. 2. Essential amino acid composition of the whole empty body

    African Journals Online (AJOL)

    tion of various tissues and organs be compared with that of the whole empty body to ... efficiency of protein and fat deposition in ruminants have been found to be ..... It has already been recognised in poultry that the proportion of total protein ...

  12. Validation of body composition models for high school wrestlers.

    Science.gov (United States)

    Williford, H N; Smith, J F; Mansfield, E R; Conerly, M D; Bishop, P A

    1986-04-01

    This study investigates the utility of two equations for predicting minimum wrestling weight and three equations for predicting body density for the population of high school wrestlers. A sample of 54 wrestlers was assessed for body density by underwater weighing, residual volume by helium dilution, and selected anthropometric measures. The differences between observed and predicted responses were analyzed for the five models. Four statistical tests were used to validate the equations, including tests for the mean of differences, proportion of positive differences, equality of standard errors from regression, and equivalence of regression coefficients between original and second sample data. The Michael and Katch equation and two Forsyth and Sinning equations (FS1 and FS21) for body density did not predict as well as expected. The Michael and Katch equation tends to overpredict body density while FS1 underpredicts. The FS2 equation, consisting of a constant adjustment to FS1, predicts well near the mean but not at the ends of the sample range. The two Tcheng and Tipton equations produce estimates which slightly but consistently overpredict minimum wrestling weight, the long form equation by 2.5 pounds and the short form by 3.8 pounds. As a result the proportion of positive differences is less than would be expected. But based on the tests for the standard errors and regression coefficients, the evidence does not uniformly reject these two equations.

  13. Trend of Body Compositions with Aging among Chinese Adolescents, Adults and Elders.

    Science.gov (United States)

    Xu, T; Zhu, G; Han, S

    2015-12-01

    Rare reports can be found about sex- and age-specific body composition survey among Chinese population. The aim of this study is to explore the change of sex-specific body compositions with aging among Chinese adolescents, adults and elders. In a large-scale population survey about physiological constants and health conditions, 75,714 subjects who aged from 8 to 80 completed body composition array. Body mass index (BMI), percentage body fat (PBF), water percentage of body weight (WPBW), water percentage of lean body mass (WPLBM), fat-free mass index (FFMI) and basic metabolic rate were examined with Biodynamics BI-310 body composition analyzer. General obesity is defined as BMI equal to or greater than 28 kg/m2. The prevalence rates of general obesity were 9.4% for males and 7.7% for females respectively. With aging, PBF and FMI showed a U-shape curvilinear trend and WPBW showed a parabolic trend for males. At same age group: 18-19 age groups, PBF and FMI declined to the valley and WPBW rose to the peak. For females, PBF, WPBW and FMI changed in a linear trend. The values of WPLBM and FFMI showed same curvilinear trend for two genders. WPLBM changed in a U-shape trend and touched the valley in twenties for males and in 18-19 age groups for females. The value of FFMI was larger for older age groups in the younger generation but smaller in the older generation. A parabolic trend peaking was seen in the thirties for males and in the forties for females. Regression models with age as independent variable showed that the larger rate of increase of PBF and smaller rates of increase for WPBM and WPLBM with aging for males. This study presents detailed data about sex-specific body composition conditions. Different change trend with aging was found about body composition conditions.

  14. Somatotype, size and body composition of competitive female volleyball players.

    Science.gov (United States)

    Malousaris, Grigoris G; Bergeles, Nikolaos K; Barzouka, Karolina G; Bayios, Ioannis A; Nassis, George P; Koskolou, Maria D

    2008-06-01

    The aim of this study was to describe the morphological characteristics of competitive female volleyball players. For this purpose, body weight and height, breadths and girths as well as skinfold thickness at various body sites were assessed in 163 elite female volleyball players (age: 23.8+/-4.7 years, years of playing: 11.5+/-4.2, hours of training per week: 11.9+/-2.9, means+/-S.D.). Seventy-nine of these players were from the A1 division and the rest from the A2 division of the Greek National League. Two-way ANOVA was used to compare the differences in these characteristics between competition level and playing position. Body height ranged from 161cm to 194cm, and the mean value (177.1+/-6.5cm) was not inferior to that of international players of similar calibre. Adiposity of these players (sum of 5 skinfolds: 51.8+/-10.2mm, percent body fat: 23.4+/-2.8) was higher than that reported in other studies in which, however, different methodology was used. Volleyball athletes of this study were mainly balanced endomorphs (3.4-2.7-2.9). The A1 division players were taller and slightly leaner with greater fat-free mass than their A2 counterparts. Significant differences were found among athletes of different playing positions which are interpreted by their varying roles and physical demands during a volleyball game. The volleyball players who play as opposites were the only subgroup of players differing between divisions; the A2 opposites had more body fat than A1 opposites. These data could be added in the international literature related to the anthropometric characteristics of competitive female volleyball players.

  15. Body composition and phase angle in Russian children in remission from acute lymphoblastic leukemia

    Science.gov (United States)

    Tseytlin, G. Ja; Khomyakova, I. A.; Nikolaev, D. V.; Konovalova, M. V.; Vashura, A. Yu; Tretyak, A. V.; Godina, E. Z.; Rudnev, S. G.

    2010-04-01

    Elevated degree of body fatness and changes in other body composition parameters are known to be common effects of treatment for acute lymphoblastic leukemia (ALL) in children. In order to study peculiarities of somatic growth and development in ALL survivors, we describe the results of BIA body composition analysis of 112 boys and 108 girls aged 5-18 years in remission from ALL (remission time range 1-13 years) compared to data from the same number of age- and sex-matched healthy controls (n=220). Detrimental effect on height in ALL boys was observed, whereas girls experienced additional weight gain compared to healthy subjects. In ALL patients, resistance, body fat, and percent body fat were significantly increased. The reactance, phase angle, absolute and relative values of skeletal muscle and body cell mass were significantly decreased. Principal component analysis revealed an early prevalence of adiposity traits in the somatic growth and development of ALL girls compared to healthy controls.

  16. Body composition of active persons with spinal cord injury and with poliomyelitis

    Science.gov (United States)

    This study sought to evaluate the body composition of subjects with active spinal cord injuries and polio. Two groups of males and females, active, free-living, of similar ages and body mass index (BMI), were distributed according to the source of deficiency: SCI – low spinal cord injury (T5-T12) an...

  17. The Pituitary Gland and Age-Dependent Regulation of Body Composition

    NARCIS (Netherlands)

    van Beek, Andre P.; Wolffenbuttel, Bruce H. R.; Runge, Evelien; Trainer, Peter J.; Jonsson, Peter J.; Koltowska-Haggstrom, Maria

    2010-01-01

    Context: The prevalence of obesity is increased in hypopituitarism. In the general population, body mass index (BMI) and waist circumference increase with advancing age. It remains uncertain whether age-related changes in pituitary function contribute to the changes in body composition associated wi

  18. The Relationship between Selected Body Composition Variables and Muscular Endurance in Women

    Science.gov (United States)

    Esco, Michael R.; Olson, Michele S.; Williford, Henry N.

    2010-01-01

    The primary purpose of this study was to determine if muscular endurance is affected by referenced waist circumference groupings, independent of body mass and subcutaneous abdominal fat, in women. This study also explored whether selected body composition measures were associated with muscular endurance. Eighty-four women were measured for height,…

  19. Psychosocial Variables Associated with Body Composition and Cardiorespiratory Fitness in Middle School Students

    Science.gov (United States)

    Greenleaf, Christy A.; Petrie, Trent A.; Martin, Scott B.

    2010-01-01

    This study examined the associations among self-esteem, depression, physical self-concept, and body satisfaction among 1,022 middle school students who were in the FITNESSGRAM[R] Healthy Fitness Zone[TM] (HFZ) compared to those in the Needs Improvement Zone (NIZ) for body composition and cardiorespiratory fitness. After controlling for…

  20. The use of bioelectrical impedance analysis for body composition in epidemiological studies

    DEFF Research Database (Denmark)

    Böhm, A; Heitmann, B L

    2013-01-01

    BACKGROUND/OBJECTIVES: Bioelectrical impedance analysis (BIA) is a relatively simple, inexpensive and non-invasive technique to measure body composition and is therefore suitable in field studies and larger surveys. SUBJECTS/METHODS: We performed an overview of BIA-derived body fat percentages (BF...

  1. Testosterone and growth hormone improve body composition and muscle performance in older men

    Science.gov (United States)

    CONTEXT: Impairments in the pituitary-gonadal axis with aging are associated with loss of muscle mass and function and accumulation of upper body fat. OBJECTIVES: We tested the hypothesis that physiological supplementation with testosterone and GH together improves body composition and muscle perfor...

  2. Body Composition in Relation to Clinical Outcomes in Renal Cell Cancer

    NARCIS (Netherlands)

    Vrieling, Alina; Kampman, Ellen; Knijnenburg, Nathalja C.; Mulders, Peter F.; Sedelaar, J.P.M.; Baracos, Vickie E.; Kiemeney, Lambertus A.

    2016-01-01

    Context: Several studies suggest that body composition (ie, body proportions of muscle and fat defined by computed tomography) is associated with clinical outcomes of several cancer types, including renal cell cancer (RCC). Objective: To conduct a systematic review and meta-analysis of the evidence

  3. Body composition and flight ranges of Bar-tailed Godwits (Limosa lapponica baueri) from New Zealand

    NARCIS (Netherlands)

    Battley, Phil F.; Piersma, Theunis; Holberton, R.L.

    2005-01-01

    Body composition analysis was performed on 37 Bar-tailed Godwits (Limosa lapponica baueri) that had been illegally shot during migratory fueling in northern New Zealand in March 1992. Adults (n = 35) were heavy (442-721 g), with fat loads of 30-45% of body mass. Two first-year males had only 5.4% an

  4. Effects of a Rebound Exercise Training Program on Aerobic Capacity and Body Composition.

    Science.gov (United States)

    Tomassoni, Teresa L.; And Others

    1985-01-01

    This study was designed to determine if aerobic dancing on rebound exercise equipment (minitrampolines) is an effective way to improve aerobic capacity and body composition. Although aerobic capacity improved, percent body fat did not change. Results were similar to those produced by conventional aerobic dance programs of like intensity. (MT)

  5. Hyperglycemia (High Blood Glucose)

    Medline Plus

    Full Text Available ... Hyperglycemia (High Blood Glucose) Hyperglycemia is the technical term for high blood glucose (blood sugar). High blood glucose happens when the body has too little insulin or when the body can't use insulin properly. What Causes Hyperglycemia? A number of things can cause hyperglycemia: ...

  6. Inadequacy of Body Weight-Based Recommendations for Individual Protein Intake-Lessons from Body Composition Analysis.

    Science.gov (United States)

    Geisler, Corinna; Prado, Carla M; Müller, Manfred J

    2016-12-31

    Current body weight-based protein recommendations are ignoring the large variability in body composition, particularly lean mass (LM), which drives protein requirements. We explored and highlighted the inter-individual variability of weight versus body composition-adjusted protein intakes by secondary analysis in three cohorts of (1) 574 healthy adults (mean ± SD age: 41.4 ± 15.2 years); (2) 403 cirrhotic patients (age: 44.7 ± 12.3 years) and (3) 547 patients with lung cancer (age: 61.3 ± 8.2 years). LM was assessed using different devices (magnetic resonance imaging, dual-energy X-ray absorptiometry, computer tomography, total body potassium and bioelectrical impedance), body weight-based protein intake, its ratio (per kg LM) and mean protein requirement were calculated. Variability in protein intake in all cohorts ranged from 0.83 to 1.77 g protein per kg LM per day using (theoretical protein intake of 60 g protein per day). Calculated mean protein requirement was 1.63 g protein per kg LM per day; consequently, 95.3% of healthy subjects, 100% of cirrhotic and 97.4% of cancer patients would present with a low protein intake per kg LM. Weight-adjusted recommendations are inadequate to address the LM specific differences in protein needs of healthy subjects or clinical populations. Absolute protein intake seems to be more relevant compared to the relative proportion of protein, which in turn changes with different energy needs.

  7. Inadequacy of Body Weight-Based Recommendations for Individual Protein Intake—Lessons from Body Composition Analysis

    Directory of Open Access Journals (Sweden)

    Corinna Geisler

    2016-12-01

    Full Text Available Current body weight-based protein recommendations are ignoring the large variability in body composition, particularly lean mass (LM, which drives protein requirements. We explored and highlighted the inter-individual variability of weight versus body composition-adjusted protein intakes by secondary analysis in three cohorts of (1 574 healthy adults (mean ± SD age: 41.4 ± 15.2 years; (2 403 cirrhotic patients (age: 44.7 ± 12.3 years and (3 547 patients with lung cancer (age: 61.3 ± 8.2 years. LM was assessed using different devices (magnetic resonance imaging, dual-energy X-ray absorptiometry, computer tomography, total body potassium and bioelectrical impedance, body weight-based protein intake, its ratio (per kg LM and mean protein requirement were calculated. Variability in protein intake in all cohorts ranged from 0.83 to 1.77 g protein per kg LM per day using (theoretical protein intake of 60 g protein per day. Calculated mean protein requirement was 1.63 g protein per kg LM per day; consequently, 95.3% of healthy subjects, 100% of cirrhotic and 97.4% of cancer patients would present with a low protein intake per kg LM. Weight-adjusted recommendations are inadequate to address the LM specific differences in protein needs of healthy subjects or clinical populations. Absolute protein intake seems to be more relevant compared to the relative proportion of protein, which in turn changes with different energy needs.

  8. Inadequacy of Body Weight-Based Recommendations for Individual Protein Intake—Lessons from Body Composition Analysis

    Science.gov (United States)

    Geisler, Corinna; Prado, Carla M.; Müller, Manfred J.

    2016-01-01

    Current body weight-based protein recommendations are ignoring the large variability in body composition, particularly lean mass (LM), which drives protein requirements. We explored and highlighted the inter-individual variability of weight versus body composition-adjusted protein intakes by secondary analysis in three cohorts of (1) 574 healthy adults (mean ± SD age: 41.4 ± 15.2 years); (2) 403 cirrhotic patients (age: 44.7 ± 12.3 years) and (3) 547 patients with lung cancer (age: 61.3 ± 8.2 years). LM was assessed using different devices (magnetic resonance imaging, dual-energy X-ray absorptiometry, computer tomography, total body potassium and bioelectrical impedance), body weight-based protein intake, its ratio (per kg LM) and mean protein requirement were calculated. Variability in protein intake in all cohorts ranged from 0.83 to 1.77 g protein per kg LM per day using (theoretical protein intake of 60 g protein per day). Calculated mean protein requirement was 1.63 g protein per kg LM per day; consequently, 95.3% of healthy subjects, 100% of cirrhotic and 97.4% of cancer patients would present with a low protein intake per kg LM. Weight-adjusted recommendations are inadequate to address the LM specific differences in protein needs of healthy subjects or clinical populations. Absolute protein intake seems to be more relevant compared to the relative proportion of protein, which in turn changes with different energy needs. PMID:28042853

  9. The Body Composition Project: A Summary Report and Descriptive Data

    Science.gov (United States)

    1986-12-01

    Hispanic American Indian/Alagan Native Asian /Pacific Islan, Table la. Percent of sample by age groups that exceeded the weight for height screening tables...category followed by Black, Hispanic, Asian /Pacific Islander and- American IndianlAlaskan Nativei respectively. Also, the 21-27 year age group make up the...questions ralating to cardiovascular disease, asthma. me.dicatlon. coffe consuvtion1 Injuries to the upper and lowor body, ss w*1 as swnking historieo

  10. Whole body air displacement plethysmography compared with hydrodensitometry for body composition analysis

    OpenAIRE

    Dewit, O; Fuller, N.; Fewtrell, M; Elia, M; Wells, J.

    2000-01-01

    AIMS—To assess the acceptability and feasibility of whole body air displacement plethysmography in children and to determine its precision and agreement with hydrodensitometry, an appropriate reference method.
METHODS—Age specific two component model equations were used to predict fat mass from body density in 22 children aged 8-12 years and in 10 adults for comparison of methods. Precision for each method was established from duplicate measurements.
RESULTS—Plethysmography ...

  11. Influence of the body mass and visceral adiposity on glucose metabolism in obese women with Pro12Pro genotype in PPARgamma2 gene

    Directory of Open Access Journals (Sweden)

    Vanessa Chaia Kaippert

    2013-06-01

    Full Text Available Introduction: Glucose metabolism may be altered in obesity and genotype for PPAR 2 can influence this variable. Objective: To evaluate the influence of body mass (BM and visceral adiposity (VA in glucose metabolism in morbid obese women with Pro12Pro genotype. Methods: Were selected 25 morbidly obese women. Groups were formed according to body mass index (BMI [G1: 40-45 kg/m² (n = 17; G2: > 45 kg/m² (n = 8]. Anthropometric, glycemia and insulinemia assessments (fasting, 60 and 120 minutes after high polyunsaturated fatty acids meal were carried out. The insulin resistance (IR and insulin sensitivity (IS were assessed by HOMA-IR and QUICKI respectively. Results: G2 had higher BMI and waist circumference, compared to G1, impaired fasting glucose, low IS and higher IR. The postprandial glucose was normal, but there was a higher insulin peak one hour after the meal in G2. Conclusion: Increased BM and VA were associated with worse glucose metabolism suggesting metabolic differences between morbid obese with Pro12Pro genotype.

  12. Effects of liraglutide and sibutramine on food intake, palatability, body weight and glucose tolerance in the gubra DIO-rats.

    Science.gov (United States)

    Hansen, Gitte; Jelsing, Jacob; Vrang, Niels

    2012-02-01

    To validate the gubra DIO-rats as a useful animal model of human obesity. The gubra diet-induced obesity (DIO) rat model was based on male Sprague-Dawley rats with ad libitum access to regular chow and a palatable diet rich in fat and sugar. To evaluate the versatility of the gubra DIO-rats as a valid model of human obesity syndrome, the efficacy of 2 weight loss compounds liraglutide and sibutramine with different mechanisms of action were examined in 7-month-old gubra DIO-rats. Liraglutide (200 μg/kg, sc) was administered bi-daily, and sibutramine (5 mg/kg, po) was administered once daily for 23 d. Both the compounds effectively reduced the food intake, body weight and total fat mass as measured by nuclear magnetic resonance. Whereas the 5-HT reuptake inhibitor/5-HT receptor agonist sibutramine reduced the intake of both chow and the gubra-diet, the GLP-1 analogue liraglutide predominantly reduced the intake of the highly palatable diet, indicating a shift in food preference. Sibutramine lowered the insulin sensitivity index, primarily via reductions in glucose-stimulated insulin secretion. This animal model responds well to 2 weight loss compounds with different mechanisms of action. Moreover, the gubra DIO-rat can be particularly useful for the testing of compounds with potential effects on diet preference.

  13. Effects of acute pinitol supplementation on plasma pinitol concentration, whole body glucose tolerance, and activation of the skeletal muscle insulin receptor in older humans.

    Science.gov (United States)

    Stull, A J; Wood, K V; Thyfault, J P; Campbell, W W

    2009-05-01

    Limited research with rodents and humans suggests that oral ingestion of pinitol (3- O-methyl- D- CHIRO-inositol) might positively influence glucose tolerance. This double-blinded, placebo-controlled, and cross-over study assessed the effects of acute pinitol supplementation on plasma pinitol concentration, glucose tolerance, insulin sensitivity, and activation of the skeletal muscle insulin receptor. Fifteen older, nondiabetic subjects (62+/-1 years, mean+/-SEM) completed four, 1-day trials. Subjects consumed a non-nutritive beverage with nothing (placebo) or 1,000 mg pinitol. Sixty minutes later, the subjects consumed beverages that were either energy- and carbohydrate-free (Sham) or contained 75 g glucose (OGTT). Blood samples were collected frequently over the 240-min testing period. For the OGTT trials only, vastus lateralis samples were obtained before the placebo and pinitol supplementation and 60 min after consuming the 75 g glucose beverage. Plasma pinitol concentration increased and was maintained for 240 min. Pinitol did not influence the fasting state and 180-min area under the curves for plasma glucose and insulin during the Sham and OGTT trials or hepatic (placebo 0.83+/-0.08; pinitol 0.80+/-0.08) and whole-body (placebo 6.10+/-0.54; pinitol 6.22+/-0.52) insulin sensitivities. Activation of the muscle insulin receptor was increased by 140% with glucose ingestion (Pre 0.62+/-0.12; Post 1.49+/-0.35), but pinitol did not influence this response. These results show that the pinitol supplement was quickly absorbed, but did not acutely influence indices of whole-body glucose tolerance and insulin sensitivity, or the activation of the skeletal muscle insulin receptor in older, nondiabetic humans.

  14. Effects of rapid weight loss and regain on body composition and energy expenditure.

    Science.gov (United States)

    Sagayama, Hiroyuki; Yoshimura, Eiichi; Yamada, Yosuke; Ichikawa, Mamiko; Ebine, Naoyuki; Higaki, Yasuki; Kiyonaga, Akira; Tanaka, Hiroaki

    2014-01-01

    Weight-classified athletes need an energy intake plan to accomplish target weight reduction. They have to consider body composition and energy metabolism during rapid weight loss followed by rapid weight regain to achieve their energy intake plan. We investigated the effects of rapid weight loss, followed by weight regain, on body composition and energy expenditure. Ten weight-classified athletes were instructed to reduce their body weight by 5% in 7 days. Following the weight loss, they were asked to try to regain all of their lost weight with an ad libitum diet for 12 h. Food intake was recorded during the baseline, weight loss, and regain periods. Fat mass, total body water, and fat-free dry solids were estimated by underwater weighing and stable isotope dilution methods. A three-component model was calculated using Siri's equation. Basal and sleeping metabolic rates were measured by indirect calorimetry. Body composition and energy expenditure were measured before and after weight loss and after weight regain. Body weight, total body water, and fat-free dry solids were decreased after the weight loss period but recovered after weight regain (p weight loss but recovered after weight regain. Changes in total body water greatly affect body weight during rapid weight loss and regain. In addition, rapid weight loss and regain did not greatly affect the basal metabolic rate in weight-classified athletes.

  15. How Accurate Are the Anthropometry Equations in in Iranian Military Men in Predicting Body Composition?

    Science.gov (United States)

    Shakibaee, Abolfazl; Faghihzadeh, Soghrat; Alishiri, Gholam Hossein; Ebrahimpour, Zeynab; Faradjzadeh, Shahram; Sobhani, Vahid; Asgari, Alireza

    2015-01-01

    Background: The body composition varies according to different life styles (i.e. intake calories and caloric expenditure). Therefore, it is wise to record military personnel’s body composition periodically and encourage those who abide to the regulations. Different methods have been introduced for body composition assessment: invasive and non-invasive. Amongst them, the Jackson and Pollock equation is most popular. Objectives: The recommended anthropometric prediction equations for assessing men’s body composition were compared with dual-energy X-ray absorptiometry (DEXA) gold standard to develop a modified equation to assess body composition and obesity quantitatively among Iranian military men. Patients and Methods: A total of 101 military men aged 23 - 52 years old with a mean age of 35.5 years were recruited and evaluated in the present study (average height, 173.9 cm and weight, 81.5 kg). The body-fat percentages of subjects were assessed both with anthropometric assessment and DEXA scan. The data obtained from these two methods were then compared using multiple regression analysis. Results: The mean and standard deviation of body fat percentage of the DEXA assessment was 21.2 ± 4.3 and body fat percentage obtained from three Jackson and Pollock 3-, 4- and 7-site equations were 21.1 ± 5.8, 22.2 ± 6.0 and 20.9 ± 5.7, respectively. There was a strong correlation between these three equations and DEXA (R² = 0.98). Conclusions: The mean percentage of body fat obtained from the three equations of Jackson and Pollock was very close to that of body fat obtained from DEXA; however, we suggest using a modified Jackson-Pollock 3-site equation for volunteer military men because the 3-site equation analysis method is simpler and faster than other methods. PMID:26715964

  16. Body composition in elderly people: effect of criterion estimates on predictive equations

    Energy Technology Data Exchange (ETDEWEB)

    Baumgartner, R.N.; Heymsfield, S.B.; Lichtman, S.; Wang, J.; Pierson, R.N. Jr. (Wright State Univ. School of Medicine, Dayton, OH (USA))

    1991-06-01

    The purposes of this study were to determine whether there are significant differences between two- and four-compartment model estimates of body composition, whether these differences are associated with aqueous and mineral fractions of the fat-free mass (FFM); and whether the differences are retained in equations for predicting body composition from anthropometry and bioelectric resistance. Body composition was estimated in 98 men and women aged 65-94 y by using a four-compartment model based on hydrodensitometry, {sup 3}H{sub 2}O dilution, and dual-photon absorptiometry. These estimates were significantly different from those obtained by using Siri's two-compartment model. The differences were associated significantly (P less than 0.0001) with variation in the aqueous fraction of FFM. Equations for predicting body composition from anthropometry and resistance, when calibrated against two-compartment model estimates, retained these systematic errors. Equations predicting body composition in elderly people should be calibrated against estimates from multicompartment models that consider variability in FFM composition.

  17. THE RESULTS OF THE ANALYSIS OF THE STUDENTS’ BODY COMPOSITION BY BIOIMPEDANCE METHOD

    Directory of Open Access Journals (Sweden)

    Dmitry S. Blinov

    2016-06-01

    Full Text Available Introduction. Tissues of the human body can conduct electricity. Liquid medium (water, blood, the contents of hollow bodies, have a low impedance, i.e. good conductors, while denser tissue (muscle, nerves, etc. resistance is significantly higher. The biggest impedance have fat and bone tissues. The bioimpendancemetry – a method which allows to determine the composition of the human body by measuring electrical resistance (impedance of its tissues. Relevance. This technique is indispensable to dieticians and fitness trainers. In addition, the results of the study can provide invaluable assistance in the appointment of effective treatment physicians, gynecologists, orthopedists, and other specialists. The bioimpedance method helps to determine the risks of developing diabetes type 2, atherosclerosis, hypertension, diseases of the musculoskeletal system, disorders of the endocrine system, gall-stone disease and etc. Materials and Methods. In the list of parameters of body composition assessed by bioimpedance analysis method, included absolute and relative indicators. Depending on the method of measurement of the absolute rates were determined for the whole body. To absolute performance were: fat and skinny body mass index, active cell and skeletal muscle mass, total body water, cellular and extracellular fluid. Along with them were calculated relatively (normalized to body weight, lean mass, or other variables indicators of body composition. Results. In the result of the comparison of anthropometric and bioimpedance method found that growth performance, vital capacity, weight, waist circumference, circumfer¬ence of waist and hip, basal metabolism, body fat mass, normalized on growth, lean mass, percentage skeletal muscle mass in boys and girls with normal and excessive body weight had statistically significant differences. Discussion and Conclusions. In the present study physical development with consideration of body composition in students

  18. Impact of body composition changes on risk of all-cause mortality in older adults

    DEFF Research Database (Denmark)

    Graf, Christophe E; Herrmann, François R; Spoerri, Adrian

    2016-01-01

    PURPOSE: This study evaluates the relationship between body mass index (BMI), fat mass index (FMI) and fat-free mass index (FFMI) changes and mortality in persons ≥65 years. METHODS: Adults ≥65 years with at least two body composition measurements (BCM) between 1990 and 2011 were included. We...... excluded persons who died within one month of the second BCM and who had two single BCM in a one-month timeframe. Mortality data was retrieved until December 2012. For each person, we calculated the regression slopes for BMI, FMI and FFMI changes. Significant positive slopes were categorized as "gain......", negative slopes as "loss" and the others as "maintenance". The impact of body composition changes was evaluated by Cox regression models while adjusting for sex, age, co-morbidities and body composition at the last measurement. RESULTS: We included 791 persons with 3049 BCM. After adjustment for sex...

  19. Comparison of nutritional intake, body composition, bone mineral density, and isokinetic strength in collegiate female dancers.

    Science.gov (United States)

    Lim, Se-Na; Chai, Joo-Hee; Song, Jong Kook; Seo, Myong-Won; Kim, Hyun-Bae

    2015-12-01

    This study compared nutritional intake, body composition, bone mineral density, and isokinetic strength by dance type in collegiate female dancers. The study subjects included Korean dancers (n=12), ballet dancers (n=13), contemporary dancers (n=8), and controls (n=12). Nutritional intake was estimated using the Computer Aided Nutritional Analysis Program. Body composition and bone mineral density were measured using dual-energy X-ray absorptiometry. Isokinetic knee joint strength was measured by Cybex 770-NORM. All statistical analyses were performed by SAS 9.2. Means and standard deviations were calculated using descriptive statistics. One-way analysis of variance was applied to evaluate nutritional intake, body composition, bone mineral density, and isokinetic strength differences. Duncan multiple range test was used for post hoc testing. A level of significance was set at Pcontemporary and ballet dancers had lower body fat percentages than controls (Pdance type and more scientific methods of dance training are needed.

  20. Body Composition and Somatotype in Adolescent Competion Swimmers

    OpenAIRE

    José Miguel Martínez-Sanz; Juan Mielgo-Ayuso; Aritz Urdampilleta

    2014-01-01

    Introduction: The swimmer is a high level athlete, with long limbs, and whose musculoskeletal components are important in sporting success. However, the fat component is paradoxical because of its relationship with the buoyancy and displacement of the body in the water. The aim of this study is to describe the anthropometric profile of adolescent competition swimmers.Material and methods: A total of 17 adolescent swimmers were evaluated, 10 boys (13.2 ±1.32 years) and 7 girls (15±1.83 years)....

  1. Voluntary exercise and its effects on body composition depend on genetic selection history.

    Science.gov (United States)

    Nehrenberg, Derrick L; Hua, Kunjie; Estrada-Smith, Daria; Garland, Theodore; Pomp, Daniel

    2009-07-01

    Little is known about how genetic variation affects the capacity for exercise to change body composition. We examined the extent to which voluntary exercise alters body composition in several lines of selectively bred mice compared to controls. Lines studied included high runner (HR) (selected for high wheel running), M16 (selected for rapid weight gain), Institute of Cancer Research (ICR) (randomly bred as control for M16), M16i (an inbred line derived from M16), HE (selected for high percentage of body fat while holding body weight constant), LF (selected for low percentage of body fat), C57BL/6J (common inbred line), and the F1 between HR and C57BL/6J. Body weight and body fat were recorded before and after 6 days of free access to running wheels in males and females that were individually caged. Total food intake was measured during this 6-day period. All pre- and postexercise measures showed significant strain effects. While HR mice predictably exercised at higher levels, all other selection lines had decreased levels of wheel running relative to ICR. The HR x B6 F1 ran at similar levels to HR demonstrating complete dominance for voluntary exercise. Also, all strains lost body fat after exercise, but the relationships between exercise and changes in percent body were not uniform across genotypes. These results indicate that there is significant genetic variation for voluntary exercise and its effects on body composition. It is important to carefully consider genetic background and/or selection history when using mice to model effects of exercise on body composition, and perhaps, other complex traits as well.

  2. Functional Body Composition and Related Aspects in Research on Obesity and Cachexia

    Science.gov (United States)

    Müller, M.J.; Baracos, V.; Bosy-Westphal, A.; Dulloo, A.; Eckel, J.; Fearon, K.C.H.; Hall, K.D.; Pietrobelli, A.; Sørensen, T.I.A.; Speakman, J.; Trayhurn, P.; Visser, M.; Heymsfield, S.B.

    2014-01-01

    The 12th Stock Conference addressed body composition and related functions in two extreme situations, obesity and cancer cachexia. The concept of “functional body composition” integrates body components into regulatory systems relating the mass of organs and tissues to corresponding in vivo functions and metabolic processes. This concept adds to an understanding of organ/tissue mass and function in the context of metabolic adaptations to weight change and disease. During weight gain and loss there are associated changes in individual body components while the relationships between organ and tissue mass are fixed. Thus, an understanding of weight regulation involves an examination of organ-tissue regulation rather than of individual organ mass. The between organ/tissue mass relationships are associated with and explained by cross-talk between organs and tissues mediated by cytokines, hormones, and metabolites that are coupled with changes in body weight, composition, and function as observed in obesity and cancer cachexia. In addition to established roles in intermediary metabolism, cell function and inflammation, organ-tissue cross-talk mediators are determinants of body composition and its’ change with weight gain and loss. The 12th Stock Conference supported Michael Stocks’ concept of gaining new insights by integrating research ideas from obesity and cancer cachexia. The conference presentations provide an in-depth understanding of body composition and metabolism. PMID:24835453

  3. Diet and exercise effects on aerobic fitness and body composition in seriously mentally ill adults.

    Science.gov (United States)

    Giannopoulou, Ifigenia; Botonis, Petros; Kostara, Christina; Skouroliakou, Maria

    2014-01-01

    Low exercise capacity and high obesity levels are the main characteristics of people with serious mental illness (SMI). We conducted a pilot study on the effects of a 3-month exercise and dietary intervention on the aerobic capacity and body composition of obese adults with SMI taking Olanzapine, a second generation antipsychotic medication known to induce weight increments. Fifty adults with SMI (15 males and 35 females) followed a 3-month weight loss intervention programme based on exercise and diet. Pre- and post-intervention, a submaximal [Formula: see text]O2 exercise test was performed in order to assess [Formula: see text]O2max anthropometric and body composition measurements were also performed. All participants were obese (body mass index (BMI): 33.61 ± 0.91 kg/m(2)). Pre- and post-intervention, a submaximal [Formula: see text]O2 exercise test on the treadmill was performed in order to assess [Formula: see text]O2max anthropometric and body composition measurements were also performed. Significant reductions in body weight, BMI, body fat and waist circumference were found from pre to post (p diet improves the aerobic capacity and body composition of obese adults with SMI, despite the use of Olanzapine.

  4. Body Composition, Sarcopenia, and Suicidal Ideation in Elderly Koreans: Hallym Aging Study.

    Science.gov (United States)

    Kim, Jeong-Hyeon; Kim, Dong-Hyun; Park, Yong Soon

    2016-04-01

    This study was conducted to assess the relationship between body composition and suicidal ideation among the Korean elderly population (n = 302; ≥ 65 years) who participated in the Hallym Aging Study in 2010. Body composition was measured using dual-energy X-ray absorptiometry, and obesity was measured by the indices of body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), and body fat percentage. Sarcopenia was defined as presence of both low muscle mass and low muscle function. Suicidal ideation was assessed using the Beck Scale for Suicide Ideation. We found no differences in body composition measures between subjects with suicidal ideation and those without. In the logistic regression analyses, there were no significant relationships for suicidal ideation according to body composition measures, including BMI, WC, WHR, WHtR, and body fat percentage in both sexes. After adjusting for age, smoking status, alcohol drinking, regular exercise, medical comorbidities, monthly income, education level, and presence of depressive symptoms, the odds ratio (OR) of suicidal ideation was higher in elderly men with sarcopenia compared to those without, whereas no significant relationships were observed in elderly women (OR 8.28, 95% confidence interval [CI] 1.20-61.34 in men; OR 0.79, 95% CI 0.07-8.43 in women). Sarcopenia is closely associated with an increased risk of suicidal ideation in elderly men.

  5. Assessments of body composition and bone parameters of lactating rats treated with diet containing flaxseed meal (Linum usitatissinum) during post-weaning period.

    Science.gov (United States)

    Cavalcante Ribeiro, Danielle; Alves da Silva, Paula Cristina; D'Avila Pereira, Aline; Ferolla da Camara Boueri, Bianca; Ribeiro Pessanha, Carolina; Duque Coutinho de Abreu, Maíra; Saldanha Melo, Henrique; Rozeno Pessoa, Letícia; da Costa, Carlos Alberto Soares; Boaventura, Gilson Teles

    2014-08-01

    There are few studies on body composition and the effects of diet on weight postpartum women. The aim was to evaluate the body composition and bone parameters in lactating rats treated with diet containing flaxseed flour during postweaning period. After weaning, the lactating rat were divided in control (n = 6) and experimental (F, n = 6) group, treated with 25% flaxseed flour diet. After 30 days, body composition by dual-energy X-ray absorptiometry, serum analysis, organs and intra-abdominal fat mass, femur and lumbar vertebra parameters were determined. The groups showed similar food intake, body mass and bone parameters. While F group showed the following: lower body (-5%), gonadal (-17%), mesenteric (-23%) and intra-abdominal (-6%) fat mass. Increase of HDL-cholesterol (+10%) and lower glucose (-15%), triglycerides (P < 0.05, -37%) and cholesterol (P < 0.05, -21%). The findings highlight the effects of flaxseed for control of adiposity and to maintain a healthy biochemical profile during the postnatal period. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  6. Management of multifactorial idiopathic epilepsy in EL mice with caloric restriction and the ketogenic diet: role of glucose and ketone bodies

    Directory of Open Access Journals (Sweden)

    Mantis John G

    2004-10-01

    Full Text Available Abstract Background The high fat, low carbohydrate ketogenic diet (KD was developed as an alternative to fasting for seizure management. While the mechanisms by which fasting and the KD inhibit seizures remain speculative, alterations in brain energy metabolism are likely involved. We previously showed that caloric restriction (CR inhibits seizure susceptibility by reducing blood glucose in the epileptic EL mouse, a natural model for human multifactorial idiopathic epilepsy. In this study, we compared the antiepileptic and anticonvulsant efficacy of the KD with that of CR in adult EL mice with active epilepsy. EL mice that experienced at least 15 recurrent complex partial seizures were fed either a standard diet unrestricted (SD-UR or restricted (SD-R, and either a KD unrestricted (KD-UR or restricted (KD-R. All mice were fasted for 14 hrs prior to diet initiation. A new experimental design was used where each mouse in the diet-restricted groups served as its own control to achieve a 20–23% body weight reduction. Seizure susceptibility, body weights, and the levels of plasma glucose and β-hydroxybutyrate were measured once/week over a nine-week treatment period. Results Body weights and blood glucose levels remained high over the testing period in the SD-UR and the KD-UR groups, but were significantly (p Conclusions The results indicate that seizure susceptibility in EL mice is dependent on plasma glucose levels and that seizure control is more associated with the amount than with the origin of dietary calories. Also, CR underlies the antiepileptic and anticonvulsant action of the KD in EL mice. A transition from glucose to ketone bodies for energy is predicted to manage EL epileptic seizures through multiple integrated changes of inhibitory and excitatory neural systems.

  7. A COMPARISON OF WEIGHT LOSS, BODY COMPOSITION AND SOME MINERAL LEVELS BEFORE COMPETITION IN ELITE WRE STLERS

    Directory of Open Access Journals (Sweden)

    C. Berkan ALPAY

    2015-08-01

    Full Text Available The aim of this study is to determine the difference between body compositions and some mineral levels of elite wrestlers (at an international level who have loss of weight and who have not loss of weight. 69 volunteer elite wrestlers inv olving in Turkey Championship participated in this study. The wrestler who had loss of weight and who had not loss of weight in order to compete in their weight class before the championship are randomly chosen and at the time of race weighing, an informat ion form including demographic information, Tanita BC 418, bioelectrical impedance analyzer (BİA with USA brand, body compositions and 5 cc of blood from their forearm venous with vacutainer ( closed blood collection system are received from wrestlers who participated in the study. The blood samples are divided into serums by centrifuged at 4000 rpm in 5 minutes by using NF - 400 model centrifuge device with Nüve brand. Whether the wrestlers have loss of weight or not is calculated with a formula after their Sodium (Na + , Blood Urea Nitrogen (BUN and Glucose levels are analyzed and they are separated into two groups according to their Plasma Osmolarity (P Osm levels. The wrestlers whose P Osm level ≤290 are discussed as the group not having loss of weight and the wrestler whose P Osm level >290 are discussed as the group having loss of weight. The information about the amount of loss of weight that they have before a race as a demographic variable is received from the sportsmen participating in this study. The basal metabolic rate, percentage of body fat, fat mass, free fat mass, total body water was determined with BİA. In the blood samples; Na + , BUN, Glucose, Iron (Fe, Calcium (Ca, Potassium (K an d Chlorine (Cl levels are measured by using kits with brand of Beckman Coulter in the AU2700 Plus model biochemical auto analyzer with brand of Beckman Coulter and Vitamin B12 and insulin levels are measured by using kits with brand of Roche in the Cobas E

  8. [Energy balance, body composition and the female athlete triad syndrome].

    Science.gov (United States)

    Weinstein, Yitzhak; Weinstein, Ayelet

    2012-02-01

    With the rising participation of women in sports events, the prevalence of eating disorders and the female athlete triad (FTS), a syndrome of disordered eating, amenorrhea, and osteoporosis, have also increased in recent years. FTS is often seen in sports that emphasize thinness (e.g. gymnastics, figure skating and dancing) and also in endurance events. Elements of the FTS are pathophysiologically linked, leading to several disease risks and even to mortality. In spite of the considerable knowledge about sports nutrition, there is no consensus as to the correct nutrition regime for the female athlete. There is consensus that minimizing fluctuations in 'target-body-weight' is an indication of a long-term energy balance. Female athletes (e.g. in endurance events and gymnastics) are less likely to achieve the recommended carbohydrates (CHO) and fat consumption due to chronic or episodic constraints of total energy intake while struggling to achieve or maintain low levels of body fat. It is recommended that dietary CHO and fat content be increased to preserve fat-free mass thus enhancing health and performance. Energy balance should also be maintained during recesses. Furthermore, within-day episodes of energy deficits/surplus (measured by the frequency and/or magnitude of the episodes) should be monitored and treated closest to the time of the incidents.

  9. Mass and body composition particularities of rugby compartments

    Directory of Open Access Journals (Sweden)

    Alexandru OPREAN

    2017-03-01

    Full Text Available The aim of this study is to identify and underline the morphological particularities of Romanian professional rugby players. This aspect can contribute to the improvement of training contents. The hypothesis of this study is that body mass values of the two compartments are in conformity with the optimal standards for this sport. The study included the players of the team Stejarii București, which comprises the best players of the Romanian championship. Among the 32 tested players, 17 are forwards and 15 backs. Evaluations were done by positions, and we drafted tables with arithmetic means and standard deviations for each position. We took several anthropometric measurements for the rugby players, thus determining the qualitative level of the body mass between the two compartments. The findings indicate that players have a certain level of morphological adaptation to specific effort by the post they occupy within the team. The players feature a hypertrophy of the muscle tissue, a phenomenon specific to strength sports. However, some of the players also had a significant amount of fat mass, which contributes to less impressive performances.

  10. Determination of maternal body composition in pregnancy and its relevance to perinatal outcomes.

    Science.gov (United States)

    McCarthy, Elizabeth A; Strauss, Boyd J G; Walker, Susan P; Permezel, Michael

    2004-10-01

    Three models and 10 specific methods for determining maternal body composition are discussed and their perinatal relevance reviewed. English language publications (1950 to January 2004) were searched electronically and by hand. Search terms included "body composition," "human," " pregnancy," "obesity," "adiposity," "regional," "2-, 3-, 4-component," "truncal," "peripheral," "central," "visceral" along with specific techniques and outcomes listed subsequently. Three models of body composition are described: 2-component being fat and fat-free mass; 3-component being fat, water, and protein; and 4-component being fat, water, protein, and osseous mineral. Ten techniques of body composition assessment are described: 1) anthropometric techniques including skinfold thicknesses and waist-hip ratio; 2) total body water (isotopically labeled); 3) hydrodensitometry (underwater weighing); 4) air-displacement plethysmography; 5) bio-impedance analysis (BIA); 6) total body potassium (TBK); 7) dual-energy x-ray absorptiometry (DEXA); 8) computed tomography (CT); 9) magnetic resonance imaging (MRI); and 10) ultrasound (USS). Most methods estimate total adiposity. Regional fat distribution-central (truncal) compared with peripheral (limb) or visceral compared with subcutaneous-is important because of regional variation in adipocyte metabolism. Skinfolds, DEXA, CT, MRI, or USS can distinguish central from peripheral fat. CT, MRI, or USS can further subdivide central fat into visceral and subcutaneous. Perinatal outcomes examined in relation to body composition include pregnancy duration, birth weight, congenital anomalies, gestational diabetes, gestational hypertension, and the fetal origins of adult disease. A few studies suggest that central compared with peripheral fat correlates better with birth weight, gestational carbohydrate intolerance, and hypertension. Means of accurately assessing maternal body composition remain cumbersome and impractical, but may more accurately

  11. Effect of Canagliflozin on Renal Threshold for Glucose, Glycemia, and Body Weight in Normal and Diabetic Animal Models

    OpenAIRE

    Yin Liang; Kenji Arakawa; Kiichiro Ueta; Yasuaki Matsushita; Chiaki Kuriyama; Tonya Martin; Fuyong Du; Yi Liu; June Xu; Bruce Conway; Jamie Conway; David Polidori; Kirk Ways; Keith Demarest

    2012-01-01

    BACKGROUND: Canagliflozin is a sodium glucose co-transporter (SGLT) 2 inhibitor in clinical development for the treatment of type 2 diabetes mellitus (T2DM). METHODS: (14)C-alpha-methylglucoside uptake in Chinese hamster ovary-K cells expressing human, rat, or mouse SGLT2 or SGLT1; (3)H-2-deoxy-d-glucose uptake in L6 myoblasts; and 2-electrode voltage clamp recording of oocytes expressing human SGLT3 were analyzed. Graded glucose infusions were performed to determine rate of urinary glucose e...

  12. In vivo body composition studies in rats: assessment of total body protein.

    Science.gov (United States)

    Yasumura, S; Stamatelatos, I E; Boozer, C N; Moore, R; Ma, R

    1998-01-01

    The precision and accuracy of a prompt-gamma neutron activation facility developed to assess total body protein in rats is estimated. The coefficient of variation of nitrogen measurement, as estimated by repeated measurements on 15 rats, was 5.5% for an equivalent dose of 60 mSv (Q = 20). Good agreement was observed in comparing the results of in vivo neutron activation analysis and chemical carcass analysis performed by the Kjeldahl method. The application of the technique in comparing the effect of a low-fat and a high-fat diet on body protein in rats is demonstrated.

  13. Body mass index and body composition scaling to height in children and adolescent

    OpenAIRE

    Chung, Sochung

    2015-01-01

    Childhood obesity prevalence has been increased and known to be related to various diseases and mortality in adult and body mass index (BMI) has been widely used as a screening tool in children with obesity. It is important to understand what BMI is and its limitations. BMI is a measure of weight adjusted for height. Weight scales to height with a power of about 2, is the basis of BMI (weight/height2) as the scaling of body weight to height across adults provides powers rounded to 2. BMI has ...

  14. Effects of muscle activity and fiber composition on glucose transport and GLUT-4.

    Science.gov (United States)

    Megeney, L A; Neufer, P D; Dohm, G L; Tan, M H; Blewett, C A; Elder, G C; Bonen, A

    1993-04-01

    We examined glucose uptake and GLUT-4 in rat muscles [soleus (Sol), plantaris (PL), extensor digitorum longus (EDL), tibialis anterior, and the red and white gastrocnemius (WG)]. In the normally innervated perfused rat hindlimb muscles the proportion of oxidative fibers was highly correlated with the muscle's insulin-stimulated 3-O-methyl-D-glucose (3-MG) uptake (R2 = 0.78) and GLUT-4 content (r = 0.94). Insulin-stimulated 3-MG uptake and GLUT-4 were also highly correlated (R2 = 0.996). In 3-day denervated muscles, insulin-stimulated 3-MG uptake was reduced in all six muscles (-41 to -14.6%, P 0.05). A very high correlation was observed between the decrements in GLUT-4 (%) and the decrements in 3-MG uptake (%; r = 0.99). The relatively greater loss in muscle activity (%) due to denervation in the Sol compared with the PL coincided with the reductions (%) in GLUT-4 and 3-MG uptake. These studies demonstrate that glucose uptake and GLUT-4 are regulated by insulin-independent means, namely the oxidative capacity of the muscle and the normal activity level of the muscle.

  15. No association between body composition and cognition in ambulatory persons with multiple sclerosis: A brief report

    Directory of Open Access Journals (Sweden)

    Brian M. Sandroff, MS

    2015-06-01

    Full Text Available There is evidence that body fat is inversely associated with cognitive functioning in adults from the general population, and this has been associated with systemic inflammation. The association between body fat and cognition might further be augmented in the presence of an immune-mediated, inflammatory disease such as multiple sclerosis (MS. This cross-sectional study investigated the associations between objective measures of body composition and cognitive function in 60 persons with MS. Participants underwent a neurological examination for generating Expanded Disability Status Scale scores, followed by the Brief International Cognitive Assessment in Multiple Sclerosis neuropsychological battery for measurement of cognitive processing speed, verbal learning and memory, and visual learning and memory. Whole-body fat mass, percent body fat, lean body mass, and bone mineral density were measured using dual-energy X-ray absorptiometry. Whole-body fat mass and percent body fat were not associated with any cognitive outcome (all p > 0.41. However, lean body mass was associated with cognitive processing speed (p 0.13. Body composition might not represent a target of interventions for improving cognitive processing speed or learning and memory in MS.

  16. Comparison in maternal body composition between Caucasian Irish and Indian women.

    LENUS (Irish Health Repository)

    Farah, N

    2012-02-01

    The use of body mass index (BMI) for the diagnosis of obesity has limitations, especially when comparing ethnic groups with different body proportions. The aim of this prospective study was to compare maternal body composition in early pregnancy between Caucasian Irish and Indian women. A total of 81 Indian women and 81 Irish Caucasian women were matched for age, parity and BMI. Maternal weight and height were measured, and body composition analysed using bioelectrical impedance. The Irish women were taller and weighed more than the Indian women (p<0.001). At any given BMI, the Indian women had a higher total body fat percentage, visceral fat level and high fat percentage than the Irish women (p=0.024, 0.001 and 0.001, respectively). Our findings suggest that lower BMI cut-offs should be used for screening for gestational diabetes mellitus in Indian women attending our antenatal services.

  17. Seasonal changes in body composition of Ctenomys talarum (Rodentia: Octodontidae): an herbivore subterranean rodent.

    Science.gov (United States)

    del Valle, Juana C; López Mañanes, Alejandra A; Busch, Cristina

    2006-09-01

    Ctenomys talarum is a subterranean herbivorous rodent whose burrow systems exhibit particular characteristics, distinct from other subterranean environments. We studied seasonal variation in body composition of C. talarum in relation to energetic requirements. Body lipid content seasonally changed in C. talarum, related to reproductive cycle and thermorregulatory mechanisms. A decrease in protein body content was found only in spring. Ash content of females was lowest when most of them are in post partum estro. Observed variations in water body content could be associated with plant water content and/or metabolic regulation. Our results show the occurrence of seasonal variations in body composition in C. talarum, which could be related to the high cost of reproduction and the subterranean life style of this species.

  18. Conjugated linoleic acid (CLA: effect modulation of body composition and lipid profile

    Directory of Open Access Journals (Sweden)

    A. Baddini Feitoza

    Full Text Available Conjugated linoleic acid (CLA refers to a family of polyunsaturated fatty acids, being represented by a group of isomers of linoleic acid called conjugated for having a double bound after a simple bound. Among its isomers, trans-10,cis-12 and cis-9, cis-12 CLA stand out. These isomers can lead to different effects on the body: anticarcinogenic, antidiabetogenic, antiatherogenesis and positive body composition alteration. The objective of this review is to describe their mechanisms of action, effects on body composition, on plasmatic lipoproteins and supplementation. Studies about CLA supplementation show its capacity of reducing fat percentage, body mass and of promoting an improvement in lipid metabolism. One of the adverse effects attributed to one of the isomers is insulin resistance by body fat redistribution. Limitations in the scientific models used in CLA researches make impossible to draw conclusions about the action of this fatty acid on human metabolism.

  19. The influence of body composition on quality of life of patients with breast cancer

    Directory of Open Access Journals (Sweden)

    Aline Porciúncula Frenzel

    2013-10-01

    Full Text Available Introduction: Unwanted changes in body composition, as well as their impact on these people's quality of life, have been little investigated in patients with breast cancer. Objetive: To assess the role of body composition on quality of life and the impact of chemotherapy on both, in women with breast cancer. Methods: It was assessed prospectively women with breast cancer in a cohort of patients undergoing chemotherapy. Body composition was estimated through bioelectrical impedance. The quality of life was evaluated using the World Health Organization quality of life questionnaire. Results: This study assessed 70 women, 77 and 73% of those were initially overweight and had excess of body fat, respectively. There was a significant increase in fat-free mass (p > 0.001, body mass index (p = 0.03 and weight (p = 0.02 while quality of life stayed the same during the study. Moreover, women with excess of body fat showed a significantly lower initial general health score, compared to those with normal body fat (p = 0.02. Conclusions: Chemotherapy proved to be a potential inducer in the weight gain in this population. We highlight the importance of further investigation about the impact of body fat accumulation on those women's quality of life.

  20. Associations between childhood body size, composition, blood pressure and adult cardiac structure: the Fels Longitudinal Study.

    Directory of Open Access Journals (Sweden)

    Roy T Sabo

    Full Text Available To determine whether childhood body size, composition and blood pressure are associated with adult cardiac structure by estimating childhood "age of divergence."385 female and 312 male participants in the Fels Longitudinal Study had echocardiographic measurements of left ventricular mass, relative wall thickness, and interventricular septal thickness. Also available were anthropometric measurements of body mass index, waist circumference, percentage body fat, fat free mass, total body fat, and systolic and diastolic blood pressures, taken in both childhood and adulthood. The age of divergence is estimated as the lowest age at which childhood measurements are significantly different between patients with low and high measurements of adult cardiac structure.Childhood body mass index is significantly associated with adult left ventricular mass (indexed by height in men and women (ages of divergence: 7.5 years and 11.5 years, respectively, and with adult interventricular septal thickness in boys (age of divergence: 9 years. Childhood waist circumference indexed by height is associated with left ventricular mass (indexed by height in boys (age of divergence: 8 years. Cardiac structure was in general not associated with childhood body composition and blood pressure.Though results are affected by adult body size, composition and blood pressure, some aspects of adult cardiac structure may have their genesis in childhood body size.

  1. Shuttle-food consumption, body composition and body weight in women

    Science.gov (United States)

    Lane, Helen W.; Frye, Sherrie; Kloeris, Vickie; Rice, Barbara; Siconolfi, Steven F.; Spector, Elisabeth; Gretebeck, Randall J.

    1992-01-01

    An experiment is conducted to determine whether the NASA Space Shuttle food system can provide the food and fluid required to mitigate weight loss and physical decomposition in 12 female subjects for 28 days. Subjects receive only foods from the Space Shuttle system for four weeks within an 11-wk monitoring period. Dual-energy X-ray absorptiometry is employed throughout the trial period to study lean body mass, percent body fat, and energy-intake levels with attention given to differences the experimental diet and the subjects' typical diet. Percent body fat is found to change significantly with losses of less than 0.05 percent, whereas energy intake based on autonomous diet choices by the participants does not vary significantly. Lean body mass remains unchanged throughout the study in which the subjects receive a relatively low-fat and low-protein menu. The 100 items on the space shuttle list of approved food items are shown to provide a palatable dietary framework for maintaining the health of female astronauts.

  2. Changes in body chemical composition with age measured by total-body neutron activation

    Energy Technology Data Exchange (ETDEWEB)

    Cohn, S.H.; Vaswani, A.; Zanzi, I.; Aloia, J.F.; Roginsky, M.S.; Ellis, K.J.

    1976-01-01

    Total-body levels of calcium and phosphorus (reflecting skeletal mass) and total-body levels of potassium (reflecting muscle mass) were measured by neutron activation analysis in 39 men and 40 women ages 30 to 90 yr. In order to intercompare the total body calcium (TBCa) values in a heterogeneous population, such as this, it was necessary to normalize the data for skeletal size. The normalization consisted of dividing the absolute calcium level by the predicted calcium level for each individual matched to a set of critical parameters. The parameter used in the computation of normal values were age, sex, muscle mass, i.e., total body potassium (TBK) and height. For the calcium data of the women, it was necessary to add an age correction factor after the age of 55 yr. The calcium ratio (mean ratio of the predicted to measured TBCa) in men was 1.000 +- 7.8 percent and in women 0.996 +- 7.1 percent. The TBCa of normal males and females can thus be predicted to +-13 percent (at the 90 percent confidence level). An exception to this was found in males (70 to 90 yr) who exhibited a mean calcium ratio greater than 1.13. (auth)

  3. Concomitant changes in sleep duration and body weight and body composition during weight loss and 3-mo weight maintenance.

    Science.gov (United States)

    Verhoef, Sanne P M; Camps, Stefan G J A; Gonnissen, Hanne K J; Westerterp, Klaas R; Westerterp-Plantenga, Margriet S

    2013-07-01

    An inverse relation between sleep duration and body mass index (BMI) has been shown. We assessed the relation between changes in sleep duration and changes in body weight and body composition during weight loss. A total of 98 healthy subjects (25 men), aged 20-50 y and with BMI (in kg/m(2)) from 28 to 35, followed a 2-mo very-low-energy diet that was followed by a 10-mo period of weight maintenance. Body weight, body composition (measured by using deuterium dilution and air-displacement plethysmography), eating behavior (measured by using a 3-factor eating questionnaire), physical activity (measured by using the validated Baecke's questionnaire), and sleep (estimated by using a questionnaire with the Epworth Sleepiness Scale) were assessed before and immediately after weight loss and 3- and 10-mo follow-ups. The average weight loss was 10% after 2 mo of dieting and 9% and 6% after 3- and 10-mo follow-ups, respectively. Daytime sleepiness and time to fall asleep decreased during weight loss. Short (≤7 h) and average (>7 to weight loss. This change in sleep duration was concomitantly negatively correlated with the change in BMI during weight loss and after the 3-mo follow-up and with the change in fat mass after the 3-mo follow-up. Sleep duration benefits from weight loss or vice versa. Successful weight loss, loss of body fat, and 3-mo weight maintenance in short and average sleepers are underscored by an increase in sleep duration or vice versa. This trial was registered at clinicaltrials.gov as NCT01015508.

  4. Validity of dual X-ray absorptiometry scanning for determination of body composition in IDDM patients

    DEFF Research Database (Denmark)

    Rosenfalck, A M; Almdal, T; Gotfredsen, A

    1995-01-01

    Data on body composition in patients with insulin-dependent diabetes mellitus (IDDM) are scarce. Dual X-ray absorptiometry (DXA) scanning has proved useful for this purpose in other groups of patients. We tested the validity of the DXA scanner for the determination of fat-free mass (FFM) and fat...... mass in IDDM patients and control subjects, as compared to other reference methods, i.e. total body potassium by 40K whole body counting (TBK), total body water by tritiated water (TBW), bioelectrical impedance analysis (BIA) and 24-h urinary creatinine excretion (Ucrea). A total of 13 healthy controls...

  5. Structure and Composition of Protein Bodies from Wild-Type and High-Lysine Barley Endosperm

    DEFF Research Database (Denmark)

    Ingversen, J.

    1975-01-01

    Protein bodies were isolated from 13 and 28 day old endosperms of barley mutant 1508 and its wild type, Bomi barley. The fine structure of the isolated protein bodies was determined by electron microscopy, and the proteins present in the preparations characterized by amino-acid analysis and SDS...... with a granular component. Particles with the same structure were present in the protein body preparation from the mutant, where, however, the granular component was the most prominent. Amino-acid composition and SDS-polyacrylamide gel electrophoresis of the proteins from the protein body preparation revealed...

  6. Performance of glucose/O2 enzymatic fuel cell based on supporting electrodes over-coated by polymer-nanogold particle composite with entrapped enzymes

    Science.gov (United States)

    Huo, W. S.; Zeng, H.; Yang, Y.; Zhang, Y. H.

    2017-03-01

    Enzymatic electrodes over-coated by thin film of nano-composite made up of polymer and functionalized nano-gold particle was prepared. Glucose/O2 membrane-free enzymatic fuel cell based on nano-composite based electrodes with incorporated glucose oxidase and laccase was assembled. This enzymatic fuel cell exhibited high energy out-put density even when applied in human serum. Catalytic cycle involved in enzymatic fuel cell was limited by oxidation of glucose occurred on bioanode resulting from impact of sophisticated interaction between active site in glucose oxidase and nano-gold particle on configuration of redox center of enzyme molecule which crippled catalytic efficiency of redox protein.

  7. [Body composition assessment and body image perception in a group of University females of the Basque Country].

    Science.gov (United States)

    Arroyo, M; Ansotegui, L; Pereira, E; Lacerda, F; Valador, N; Serrano, L; Rocandio, A Ma

    2008-01-01

    [corrected] To assess the body image perception and to compare the results with the true measurements in a group of university students. Participants were 28 volunteer females recruited from the degree in Human Nutrition and Dietetic from the University of the Basque Country (Spain). All participants gave their informed consent. The mean (SD) age of the participants was 22.01 (2.12) years (20,23-28,25). Anthropometric measurement estimated directly and the derived indexes were compared with reference values. The assessment of body image perception was made using a somatomorphic software. The difference between the perceived measurements and the ideals were used as measure of body dissatisfaction. Data were analyzed using SPSS vs 14.0. Prevalence of overweight and obesity was 10.7%, and of under-weight was 70.1%. The body fat perception was well, while the perception of the muscle index was significantly different from the real measure (3.91+/-2.75 kg/m2; P<0.001). The level of body dissatisfaction was higher for the body fat (6.00+/-8.61%; P<0.001) than for the muscle index (1.65+/-2.82 kg/m2; P<0.01). This result can be justified for the present canons of beauty and for the overvaluation of the thinness. Additional research is needed to further know the relation between female body image and true measurements of body composition. Future research will allow to compare the results with other populations.

  8. Relationship between perilipin gene polymorphisms and body weight and body composition during weight loss and weight maintenance.

    Science.gov (United States)

    Soenen, Stijn; Mariman, Edwin C M; Vogels, Neeltje; Bouwman, Freek G; den Hoed, Marcel; Brown, Louise; Westerterp-Plantenga, Margriet S

    2009-03-23

    Genetic variation in the perilipin (PLIN) gene may play a role in the etiology and treatment of obesity. To examine different polymorphisms in the PLIN gene in relation to body-weight regulation. 118 subjects followed a 6 wk VLCD, followed by 1 year weight maintenance. Body-weight (BW), body composition, leptin concentration, and polymorphisms of the PLIN gene: PLIN1:rs2289487, PLIN4:rs894160, PLIN6:rs1052700, PLIN5:rs2304795 and PLIN7:rs 2304796 were determined. BW loss during VLCD was 7.0+/-3.1 kg (p0.9, r2=0.72; PLIN5 and PLIN7: D' >0.9, r2=0.85. In men, body weight, BMI, waist circumference, body fat, leptin concentrations were significantly lower for the haplotype of PLIN1 (C-alleles) and PLIN4 (A-alleles). In women weight loss and loss of fat mass were larger for the haplotype of PLIN1 (C-alleles) and PLIN4 (A-alleles). For PLIN6 genotypes body weight and body fat were lower for homozygotes of the minor allele (T/T) in the men; in the women leptin concentrations were lower. The haplotype of PLIN5 and PLIN7 consisting of A/G and G/G of PLIN5 and A/A of PLIN7 showed a reduction in FM: 5.9+/-0.6 kg vs 3.1+/-0.4 kg, % body fat: 5.5+/-0.6% vs 2.2+/-0.2%, and leptin: 20.5+/-10.8 ng/ml vs 12.9+/-6.7 ng/ml over time in the women (pinfluencer of obesity risk in humans.

  9. Effects of Dietary Garlic Extracts on Whole Body Amino Acid and Fatty Acid Composition, Muscle Free Amino Acid Profiles and Blood Plasma Changes in Juvenile Sterlet Sturgeon,

    Directory of Open Access Journals (Sweden)

    Dong-Hoon Lee

    2012-10-01

    Full Text Available A series of studies were carried out to investigate the supplemental effects of dietary garlic extracts (GE on whole body amino acids, whole body and muscle free amino acids, fatty acid composition and blood plasma changes in 6 month old juvenile sterlet sturgeon (Acipenser ruthenus. In the first experiment, fish with an average body weight of 59.6 g were randomly allotted to each of 10 tanks (two groups of five replicates, 20 fish/tank and fed diets with (0.5% or without (control GE respectively, at the level of 2% of fish body weight per day for 5 wks. Whole body amino acid composition between the GE and control groups were not different (p>0.05. Among free amino acids in muscle, L-glutamic acid, L-alanine, L-valine, L-leucine and L-phenylalanine were significantly (p0.05 were noticed at 12 h (74.6 vs 73.0. Plasma insulin concentrations (μIU/ml between the two groups were significantly (p<0.05 different at 1 (10.56 vs 5.06 and 24 h (32.56 vs 2.96 after feeding. The present results suggested that dietary garlic extracts could increase dietary glucose utilization through the insulin secretion, which result in improved fish body quality and feed utilization by juvenile sterlet sturgeon.

  10. Nesfatin-1 in childhood and adolescent obesity and its association with food intake, body composition and insulin resistance.

    Science.gov (United States)

    Anwar, Ghada M; Yamamah, Gamal; Ibrahim, Amani; El-Lebedy, Dalia; Farid, Tarek M; Mahmoud, Rasha

    2014-01-10

    Nesfatin-1 is an anorexigenic peptide that controls feeding behavior and glucose homeostasis. However, there is little data that exists regarding nesfatin-1 secretion in obese children and young adolescents. The aim of this study is to investigate serum nesfatin-1 in childhood and adolescent obesity and to study potential correlations with food intake, anthropometric indices, body composition and insulin resistance. Forty obese children and adolescents and 40 healthy control subjects were studied. Anthropometric measurements were assessed, dietary food intake was evaluated based on 3-days food record and body composition indices were evaluated using bioelectrical impedance analysis. Lipid profile, fasting blood sugar, fasting insulin and HOMA-IR were measured. Fasting serum nesfatin-1 was quantitatively assayed by ELISA. Serum nesfatin-1 was significantly higher in obese group (2.49±1.96 ng/ml) than in control group (0.70±0.81 ng/ml), P=0.001. Positive correlations with serum insulin (P=0.001), HOMA-IR (P=0.000), BMI-SDS (P=0.04), body fat % (P=0.000), fat mass (P=0.000), fat free mass (P=0.03), CHO % (P=0.000), and saturated fat % (P=0.01) were found. While significant negative correlation with protein % (P=0.000) was observed. In conclusion, our results denote that nesfatin-1 might have an important role in regulation of food intake and pathogenesis of insulin resistance in obese children and young adolescents. Copyright © 2014 Elsevier B.V. All rights reserved.

  11. Estimating body composition from skinfold thicknesses and bioelectrical impedance analysis in cystic fibrosis patients.

    Science.gov (United States)

    Alicandro, Gianfranco; Battezzati, Alberto; Bianchi, Maria Luisa; Loi, Silvana; Speziali, Chiara; Bisogno, Arianna; Colombo, Carla

    2015-11-01

    The accuracy of body composition estimates based on skinfold thickness measurements and bioelectrical impedance analysis (BIA) is not yet adequately explored in cystic fibrosis (CF). Using DXA as reference method we verified the accuracy of these techniques and identified predictors of body composition specific for CF. One hundred forty-two CF patients (age range: 8-31 years) underwent a DXA scan. Body fat percentage (BF%) was estimated from skinfolds, while fat free mass (FFM) from single-frequency 50 kHz BIA. Bland-Altman analysis showed poor intra-individual agreement between body composition data provided by DXA and BF% estimated from skinfolds or FFM estimated from BIA. The skinfolds of the upper arm were better predictors of BF% than BMI, while compared to other BIA measurements the best predictor of FFM was the R-index (Height(2)/Resistance). Due to poor accuracy at individual level, the estimates of body composition obtained from these techniques cannot be part of the standard nutritional assessment of CF patients until reliable CF-specific equations will become available. BMI has limited value in predicting body fatness in CF patients and should be used in combination with other predictors. Skinfolds of the upper arm and R-index are strongly related to BF% and FFM and should be tested in a large CF population to develop specific predictive equations. Copyright © 2015 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

  12. Maternal weight and body composition in the first trimester of pregnancy.

    LENUS (Irish Health Repository)

    Fattah, Chro

    2012-02-01

    OBJECTIVE: Previous studies on weight gain in pregnancy suggested that maternal weight on average increased by 0.5-2.0 kg in the first trimester of pregnancy. This study examined whether mean maternal weight or body composition changes in the first trimester of pregnancy. DESIGN: Prospective observational study. POPULATION: We studied 1,000 Caucasian women booking for antenatal care in the first trimester of pregnancy. SETTING: Large university teaching hospital. METHODS: Maternal height and weight were measured digitally in a standardized way and Body Mass Index (BMI) was calculated. Maternal body composition was measured using segmental multifrequency Bioelectrical Impedance Analysis (BIA). Sonographic examination confirmed the gestational age and a normal ongoing singleton pregnancy in all subjects. MAIN OUTCOME MEASURES: Maternal weight, maternal body composition. RESULTS: The mean BMI was 25.7 kg\\/m(2) and 19.0% of the women were in the obese category (> or =30.0 kg\\/m(2)). Cross-sectional analysis by gestational age showed that there was no change in mean maternal weight, BMI, total body water, fat mass, fat-free mass or bone mass before 14 weeks gestation. CONCLUSIONS: Contrary to previous reports, mean maternal weight and mean body composition values remain unchanged in the first trimester of pregnancy. This has implications for guidelines on maternal weight gain during pregnancy. We also recommend that calculation of BMI in pregnancy and gestational weight gain should be based on accurate early pregnancy measurements, and not on self-reported or prepregnancy measurements.

  13. Controlling parental feeding practices and child body composition in ethnically and economically diverse preschool children.

    Science.gov (United States)

    Wehrly, Sarah E; Bonilla, Chantal; Perez, Marisol; Liew, Jeffrey

    2014-02-01

    Controlling parental feeding practices may be associated with childhood overweight, because coercive or intrusive feeding practices may negatively impact children's development of self-regulation of eating. This study examined pressuring or forcing a child (healthy or unhealthy foods) and restricting child from unhealthy or snack foods as two types of controlling feeding practices that explain unique variances in measures of child body composition (BMI, percent body fat, and parental perception of child weight). In an ethnically and economically diverse sample of 243 children aged 4-6years old and their biological parents (89% biological mothers, 8% biological fathers, and 3% step or grand-parent), descriptive statistics indicate ethnic and family income differences in measures of feeding practices and child body composition. Additionally, the two "objective" indices of body composition (BMI and percent body fat) were related to low pressure to eat, whereas the "subjective" index (perceived child weight) was related to restriction. Regression analyses accounting for ethnic and family income influences indicate that pressure to eat and restriction both explained unique variances in the two "objective" indices of body composition, whereas only restriction explained variance in perceived child weight. Findings have implications for helping parents learn about feeding practices that promote children's self-regulation of eating that simultaneously serves as an obesity prevention strategy.

  14. Neonatal Body Composition: Measuring Lean Mass as a Tool to Guide Nutrition Management in the Neonate.

    Science.gov (United States)

    Rice, Melissa S; Valentine, Christina J

    2015-10-01

    Neonatal nutrition adequacy is often determined by infant weight gain. The aim of this review is to summarize what is currently known about neonatal body composition and the use of body composition as a measure for adequate neonatal nutrition. Unlike traditional anthropometric measures of height and weight, body composition measurements account for fat vs nonfat mass gains. This provides a more accurate picture of neonatal composition of weight gain. Providing adequate neonatal nutrition in the form of quantity and composition can be a challenge, especially when considering the delicate balance of providing adequate nutrition to preterm infants for catch-up growth. Monitoring weight gain as fat mass and nonfat mass while documenting dietary intake of fat, protein, and carbohydrate in formulas may help provide the medical community the tools to provide optimal nutrition for catch-up growth and for improved neurodevelopmental outcomes. Tracking body composition in term and preterm infants may also provide critical future information concerning the nutritional state of infants who go on to develop future disease such as obesity, hypertension, and hyperlipidemia as adolescents or adults. © 2015 American Society for Parenteral and Enteral Nutrition.

  15. Compartmentalization of membrane trafficking, glucose transport, glycolysis, actin, tubulin and the proteasome in the cytoplasmic droplet/Hermes body of epididymal sperm.

    Science.gov (United States)

    Au, Catherine E; Hermo, Louis; Byrne, Elliot; Smirle, Jeffrey; Fazel, Ali; Kearney, Robert E; Smith, Charles E; Vali, Hojatollah; Fernandez-Rodriguez, Julia; Simon, Paul H G; Mandato, Craig; Nilsson, Tommy; Bergeron, John J M

    2015-08-01

    Discovered in 1909 by Retzius and described mainly by morphology, the cytoplasmic droplet of sperm (renamed here the Hermes body) is conserved among all mammalian species but largely undefined at the molecular level. Tandem mass spectrometry of the isolated Hermes body from rat epididymal sperm characterized 1511 proteins, 43 of which were localized to the structure in situ by light microscopy and two by quantitative electron microscopy localization. Glucose transporter 3 (GLUT-3) glycolytic enzymes, selected membrane traffic and cytoskeletal proteins were highly abundant and concentrated in the Hermes body. By electron microscope gold antibody labelling, the Golgi trafficking protein TMED7/p27 localized to unstacked flattened cisternae of the Hermes body, as did GLUT-3, the most abundant protein. Its biogenesis was deduced through the mapping of protein expression for all 43 proteins during male germ cell differentiation in the testis. It is at the terminal step 19 of spermiogenesis that the 43 characteristic proteins accumulated in the nascent Hermes body.

  16. Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism.

    Science.gov (United States)

    Kumar, Anil; Lawrence, John C; Jung, Dae Young; Ko, Hwi Jin; Keller, Susanna R; Kim, Jason K; Magnuson, Mark A; Harris, Thurl E

    2010-06-01

    Rictor is an essential component of mammalian target of rapamycin (mTOR) complex (mTORC) 2, a kinase that phosphorylates and activates Akt, an insulin signaling intermediary that regulates glucose and lipid metabolism in adipose tissue, skeletal muscle, and liver. To determine the physiological role of rictor/mTORC2 in insulin signaling and action in fat cells, we developed fat cell-specific rictor knockout (FRic(-/-)) mice. Insulin signaling and glucose and lipid metabolism were studied in FRic(-/-) fat cells. In vivo glucose metabolism was evaluated by hyperinsulinemic-euglycemic clamp. Loss of rictor in fat cells prevents insulin-stimulated phosphorylation of Akt at S473, which, in turn, impairs the phosphorylation of downstream targets such as FoxO3a at T32 and AS160 at T642. However, glycogen synthase kinase-3beta phosphorylation at S9 is not affected. The signaling defects in FRic(-/-) fat cells lead to impaired insulin-stimulated GLUT4 translocation to the plasma membrane and decreased glucose transport. Furthermore, rictor-null fat cells are unable to suppress lipolysis in response to insulin, leading to elevated circulating free fatty acids and glycerol. These metabolic perturbations are likely to account for defects observed at the whole-body level of FRic(-/-) mice, including glucose intolerance, marked hyperinsulinemia, insulin resistance in skeletal muscle and liver, and hepatic steatosis. Rictor/mTORC2 in fat cells plays an important role in whole-body energy homeostasis by mediating signaling necessary for the regulation of glucose and lipid metabolism in fat cells.

  17. Fat Cell–Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism

    Science.gov (United States)

    Kumar, Anil; Lawrence, John C.; Jung, Dae Young; Ko, Hwi Jin; Keller, Susanna R.; Kim, Jason K.; Magnuson, Mark A.; Harris, Thurl E.

    2010-01-01

    OBJECTIVE Rictor is an essential component of mammalian target of rapamycin (mTOR) complex (mTORC) 2, a kinase that phosphorylates and activates Akt, an insulin signaling intermediary that regulates glucose and lipid metabolism in adipose tissue, skeletal muscle, and liver. To determine the physiological role of rictor/mTORC2 in insulin signaling and action in fat cells, we developed fat cell–specific rictor knockout (FRic−/−) mice. RESEARCH DESIGN AND METHODS Insulin signaling and glucose and lipid metabolism were studied in FRic−/− fat cells. In vivo glucose metabolism was evaluated by hyperinsulinemic-euglycemic clamp. RESULTS Loss of rictor in fat cells prevents insulin-stimulated phosphorylation of Akt at S473, which, in turn, impairs the phosphorylation of downstream targets such as FoxO3a at T32 and AS160 at T642. However, glycogen synthase kinase-3β phosphorylation at S9 is not affected. The signaling defects in FRic−/− fat cells lead to impaired insulin-stimulated GLUT4 translocation to the plasma membrane and decreased glucose transport. Furthermore, rictor-null fat cells are unable to suppress lipolysis in response to insulin, leading to elevated circulating free fatty acids and glycerol. These metabolic perturbations are likely to account for defects observed at the whole-body level of FRic−/− mice, including glucose intolerance, marked hyperinsulinemia, insulin resistance in skeletal muscle and liver, and hepatic steatosis. CONCLUSIONS Rictor/mTORC2 in fat cells plays an important role in whole-body energy homeostasis by mediating signaling necessary for the regulation of glucose and lipid metabolism in fat cells. PMID:20332342

  18. Assessment of body composition by dual-energy X-ray absorptiometry, bioimpedance analysis and anthropometrics in children

    DEFF Research Database (Denmark)

    Tompuri, Tuomo T; Lakka, Timo A; Hakulinen, Mikko;

    2015-01-01

    We compared InBody720 segmental multifrequency bioimpedance analysis (SMF-BIA) with Lunar Prodigy Advance dual-energy X-ray absorptiometry (DXA) in assessment of body composition among 178 predominantly prepubertal children. Segmental agreement analysis of body compartments was carried out, and i......, and inter-relationships of anthropometric and other measures of body composition were defined. Moreover, the relations of different reference criteria for excess body fat were evaluated....

  19. Workstation Related Anthropometric and Body Composition Parameters of Indian Women of Different Geographical Regions

    Directory of Open Access Journals (Sweden)

    Inderjeet Singh

    2015-01-01

    Full Text Available Background: Anthropometry plays an important role in industrial design, clothing design, ergonomics and architecture where statistical data about the distribution of body dimensions in the population are used to optimize products. Changes in lifestyles, nutrition, and ethnic composition of populations lead to changes in the distribution of body dimensions (e.g. the obesity epidemic, and require regular updating of anthropometric data collections. Aim and Objectives: This study analyzed the variation in anthropometric dimensions and body composition parameters of working women employees of different geographical zones. Material and Methods: The study was undertaken on nine hundred forty (940 women employees of Defence Research and Development Organization (DRDO working in seventeen different laboratories and belonged to different states of India. The age range of studied women was between 20-60 years. Fourteen body dimensions namely stature, popliteal height, knee height, buttock to popliteal length, hip breadth, waist breadth, shoulder breadth, forearm length, arm length, eye height (sitting, sitting shoulder height, hand length, hand breadth and elbow width were measured in cm using Martin anthropometers and Martin's sliding caliper. Body composition parameters like weight, percentage body fat, fat mass and fat free mass were recorded. Results: All anthropometric parameters were found significantly different (p<0.001. Body composition variables of women were also found significantly different in all three zones but fat free mass was not significantly different. Conclusion:It can be concluded that diet, environmental conditions and living style of different regions can influence the anthropometry and body composition of the individuals, however the influence of ethnic, genetic and hereditary factor are not controlled in this study.

  20. Effects of whole body vibration training on body composition, skeletal muscle strength, and cardiovascular health

    OpenAIRE

    Park, Song-Young; Son, Won-Mok; Kwon, Oh-Sung

    2015-01-01

    Whole body vibration training (WBVT) has been used as a supplement to conventional exercise training such as resistance exercise training to improve skeletal muscle strength, specifically, in rehabilitation field. Recently, this exercise modality has been utilized by cardiovascular studies to examine whether WBVT can be a useful exercise modality to improve cardiovascular health. These studies reported that WBVT has not only beneficial effects on muscular strength but also cardiovascular heal...

  1. Height and Body Composition Determine Arm Propulsive Force in Youth Swimmers Independent of a Maturation Stage

    Directory of Open Access Journals (Sweden)

    Moura Tatiane

    2014-10-01

    Full Text Available The aim of this study was to examine the relationship between anthropometric variables, body composition and propulsive force in swimmers aged 9-17 years. Anthropometric characteristics (body height and mass, sitting height, arm span, arm muscle area and body composition and the propulsive force of the arm (tethered swimming test were evaluated in 56 competitive male swimmers. Tanner’s stages of genital maturation (P1-5 were used. The data analysis included correlations and multiple linear regression. The propulsive force of the arm was correlated with body height (r = 0.34; p =0.013, arm span (r = 0.29; p =0.042, sitting height (r = 0.36; p =0.009, % body fat (r = 0.33; p =0.016, lean body mass (r = 0.34; p =0.015 and arm muscle area (r = 0.31; p =0.026. Using multiple linear regression models, the percent body fat and height were identified as significant predictors of the propulsive force of the arm after controlling for the maturation stage. This model explained 22% (R2 = 0.22 of associations. In conclusion, the propulsive force of swimmers was related to body height and percent body fat

  2. Use of bioelectrical impedance analysis to determine body composition changes in HIV-associated wasting.

    Science.gov (United States)

    Klauke, Stephan; Fischer, Harald; Rieger, Armin; Frühauf, Lukas; Staszewski, Schlomo; Althoff, Peter-Henning; Helm, Eilke Brigitte

    2005-04-01

    AIDS wasting syndrome results in loss of lean body mass and body cell mass. This 12-week, open-label study used bioelectrical impedance analysis to measure body composition changes in 24 patients with AIDS wasting syndrome receiving recombinant human growth hormone (r-hGH). The primary endpoint was percentage monthly change in body weight before/after r-hGH. Secondary endpoints included change from baseline in body composition (bioelectrical impedance analysis), isometric strength and CD4+ count. Twenty patients completed the study: r-hGH resulted in mean weight gains (+2.7%, P = 0.146), and significant increases in mean body cell mass (+8.0%, P = 0.0211), lean body mass (+4.8%, P = 0.0373) and water (+5.5%, P r-hGH was generally well tolerated; the most frequent adverse events were fever (7.3%) and diarrhoea (6.3%). Thus, bioelectrical impedance analysis can detect improved body cell mass independent of changes in body weight resulting from r-hGH treatment in patients with AIDS wasting syndrome.

  3. Body composition and prediction equations using skinfold thickness for body fat percentage in Southern Brazilian adolescents.

    Science.gov (United States)

    Ripka, Wagner Luis; Ulbricht, Leandra; Gewehr, Pedro Miguel

    2017-01-01

    The purpose of this study was to: a) determine the nutritional status of Brazilian adolescents, and; b) present a skinfold thickness model (ST) to estimate body fat developed with Brazilian samples, using dual energy x-ray absorptiometry (DXA) as reference method. The main study group was composed of 374 adolescents, and further 42 adolescents for the validation group. Weight, height, waist circumference measurements, and body mass index (BMI) were collected, as well as nine ST-biceps (BI), triceps (TR), chest (CH), axillary (AX) subscapularis (SB), abdominal (AB), suprailiac (SI), medial thigh (TH), calf (CF), and fat percentage (%BF) obtained by DXA. The prevalence of overweight in adolescents was 20.9%, and obesity 5.8%. Regression analysis through ordinary least square method (OLS) allowed obtainment of three equations with values of R2 = 0.935, 0.912 and 0.850, standard error estimated = 1.79, 1.78 and 1.87, and bias = 0.06, 0.20 and 0.05, respectively. the innovation of this study lies in presenting new regression equations for predicting body fat in Southern Brazilian adolescents based on a representative and heterogeneous sample from DXA.

  4. Use of a novel pediatric body composition technique for assessing body fatness and its changes during the first 6 month of life

    Science.gov (United States)

    BACKGROUND: Clinical assessment of infant growth and nutritional status is enhanced by accurate measurement of body composition and its changes over time. OBJECTIVE: To evaluate the accuracy of an air-displacement plethysmograph, the PEA POD (Registered Trademark) Infant Body Composition System (Lif...

  5. Body composition, dietary composition, and components of metabolic syndrome in overweight and obese adults after a 12-week trial on dietary treatments focused on portion control, energy density, or glycemic index

    Directory of Open Access Journals (Sweden)

    Melanson Kathleen J

    2012-08-01

    Full Text Available Abstract Background Given the rise in obesity and associated chronic diseases, it is critical to determine optimal weight management approaches that will also improve dietary composition and chronic disease risk factors. Few studies have examined all these weight, diet, and disease risk variables in subjects participating in recommended multi-disciplinary weight loss programs using different dietary strategies. Methods This study compared effects of three dietary approaches to weight loss on body composition, dietary composition and risk factors for metabolic syndrome (MetS. In a 12-week trial, sedentary but otherwise healthy overweight and obese adults (19 M & 138 F; 38.7 ± 6.7 y; BMI 31.8 ± 2.2 who were attending weekly group sessions for weight loss followed either portion control, low energy density, or low glycemic index diet plans. At baseline and 12 weeks, measures included anthropometrics, body composition, 3-day food diaries, blood pressure, total lipid profile, HOMA, C-reactive protein, and fasting blood glucose and insulin. Data were analyzed by repeated measures analysis of variance. Results All groups significantly reduced body weight and showed significant improvements in body composition (p  Conclusion Different dietary approaches based on portion control, low energy density, or low glycemic index produced similar, significant short-term improvements in body composition, diet compositin, and MetS components in overweight and obese adults undergoing weekly weight loss meetings. This may allow for flexibility in options for dietary counseling based on patient preference.

  6. Effects of Intragastric Balloon on Body Mass Index, Lipid Profile and Blood Glucose Regulation: A Prospective Study

    Directory of Open Access Journals (Sweden)

    Hasan Erdem

    2016-03-01

    Full Text Available Objective: Obesity remains an increasing public health and socioeconomic problem. Life style changes including healthy diet and physical activity are the first-line therapy for successful weight loss. The intragastric balloon has been considered as an effective and reversible, non-sur­gical method for weight loss. In this study, we aimed to investigate the effects of Intragastric balloon on weight loss, lipid profiles and blood glucose regulation in obese patients Methods: 75 consecutive Intragastric balloon patients (55 Female, 20 Male with a mean age of 35.2±9.6 years were included in this study. The study was conducted prospectively and an air-filled intragastric balloon was introduced in ambulatory settings. In this study, patients’ pre-intervention body mass index, peripheral blood pa­rameters such as HbA1c, lipid profiles were recorded and compared with post-intervention values. Results: The median intervention time for intragastric balloon application was 13 min (8-19. After follow-up period of median 186 days (180-211, BMI was reduced significantly, 41.6±6.7 vs. 34.9±6.4 kg/m2 (p0.05. On the other hand, only pre and post-intervention HbA1c level was to be statistically significant (p=0.001 Conclusion: There was significant change in BMI and HbA1c level with the intervention of intragastric balloon after follow-up period. For long-term benefit of balloon, further studies are needed.

  7. Measures of cardiorespiratory fitness in relation to measures of body size and composition among children.

    Science.gov (United States)

    Tompuri, Tuomo; Lintu, Niina; Savonen, Kai; Laitinen, Tomi; Laaksonen, David; Jääskeläinen, Jarmo; Lakka, Timo A

    2015-11-01

    In the exercise testing measures of cardiorespiratory fitness need to be scaled by body size or composition to enable comparison between individuals. Traditionally used weight-proportional measures are potentially confounded by body adiposity that hampers their interpretation and applicability in the clinical assessment of cardiorespiratory fitness. We aimed to find the most appropriate measure of body size or composition for scaling of measures of cardiorespiratory fitness among children. We assessed body weight and height, maximal workload (W MAX ) and maximal oxygen uptake (VO2 MAX ) using cycle ergometer exercise test with respiratory gas analysis and body lean mass (LM) and fat mass (FM) by dual-energy X-ray absorptiometry and by bioimpedance analysis among 38 children. The data were analysed using Pearson's coefficients for correlation and stepwise linear regression models. Lean mass (r > 0.54) and height (r > 0.51) had stronger positive correlations with absolute W MAX and VO2 MAX than weight (r > 0.30) in girls and boys. None of the measures of body size or composition correlated with LM-proportional W MAX or VO2 MAX in girls or boys. Only LM correlated positively with height-proportional W MAX (r = 0.65) and VO2 MAX (r = 0.71) in boys. FM correlated negatively with weight-proportional W MAX (r VO2 MAX (r MAX (β = -0.68) and VO2 MAX (β = -0.61) than exercise performance in multivariate linear regression models. While assessing cardiorespiratory fitness, LM is the most appropriate measure of body size or composition for scaling of W MAX and VO2 MAX, because scaling by body weight introduces confounding by body adiposity. © 2014 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.

  8. Crossfit-based high-intensity power training improves maximal aerobic fitness and body composition.

    Science.gov (United States)

    Smith, Michael M; Sommer, Allan J; Starkoff, Brooke E; Devor, Steven T

    2013-11-01

    The purpose of this study was to examine the effects of a crossfit-based high-intensity power training (HIPT) program on aerobic fitness and body composition. Healthy subjects of both genders (23 men, 20 women) spanning all levels of aerobic fitness and body composition completed 10 weeks of HIPT consisting of lifts such as the squat, deadlift, clean, snatch, and overhead press performed as quickly as possible. Additionally, this crossfit-based HIPT program included skill work for the improvement of traditional Olympic lifts and selected gymnastic exercises. Body fat percentage was estimated using whole-body plethysmography, and maximal aerobic capacity (VO2max) was measured by analyzing expired gasses during a Bruce protocol maximal graded treadmill test. These variables were measured again after 10 weeks of training and compared for significant changes using a paired t-test. Results showed significant (p < 0.05) improvements of VO2max in men (43.10 ± 1.40 to 48.96 ± 1.42 ml · kg · min) and women (35.98 ± 1.60 to 40.22 ± 1.62 ml · kg · min) and decreased body fat percentage in men (22.2 ± 1.3 to 18.0 ± 1.3) and women (26.6 ± 2.0 to 23.2 ± 2.0). These improvements were significant across all levels of initial fitness. Significant correlations between absolute oxygen consumption and oxygen consumption relative to body weight was found in both men (r = 0.83, p < 0.001) and women (r = 0.94, p < 0.001), indicating that HIPT improved VO2max scaled to body weight independent of changes to body composition. Our data show that HIPT significantly improves VO2max and body composition in subjects of both genders across all levels of fitness.

  9. The differences between aromatizable and non-aromatizable androgens in relation to body composition and metabolic syndrome risk factors in men.

    Science.gov (United States)

    Pospíšilová, H; Vaňková, M; Hill, M; Meloun, M; Bendlová, B; Dušková, M; Stárka, L

    2012-10-01

    The relationships between the parameters of metabolic syndrome and non-aromatizable metabolites of testosterone have been discussed in literature. Some papers describe these metabolites as one of the possible causes of male-type obesity. On the contrary, other studies show a protective influence of dihydrotestosterone on visceral obesity. The aim of this study to analyse the relationship between anthropometric parameters, lipid spectrum, glycemia and the level of endogenous testosterone and dihydrotestosterone, and to compare the effects of these androgens. Our population-based study involved 232 healthy men ranging from 20 to 78 years with BMI 18 to 39 kg/m(2). Serum testosterone, dihydrotestosterone and sex hormone binding globulin SHBG levels, lipid spectrum, glucose metabolism parameters were measured and the oral glucose tolerance test was carried out in all subjects. Their anthropometric parameters (weight, height, waist, hips, waist-to-hip ratio, 14 skin folds) and body composition parameters were determined and calculated by the Antropo program. Multiple regression analysis showed a correlation between hormonal levels, esp. of testosterone and dihydrotestosterone, and the anthropometric data, lipid spectrum and parameters of glucose regulation. Low testosterone and/or dihydrotestosterone was correlated to a higher body-mass index, fat content, waist diameter, total-, HDL-, LDL-cholesterol and triglycerides, fasting glucose, insulin resistance and lower muscle and bone mass. In addition, statistical analysis using multivariate regression with reduction in dimensionality did not discover any striking difference between aromatizable and non-aromatizable androgens in their association to lipid and glucose metabolism parameters in healthy, normosthenic men. In conclusion, the association of endogenous testosterone and dihydrotestosterone to anthropometric data, lipid spectrum and insulin sensitivity are of the same quality; however, the effect of the circulating

  10. Altered skeletal muscle fiber composition and size precede whole-body insulin resistance in young men with low birth weight

    DEFF Research Database (Denmark)

    Jensen, Christine B; Storgaard, Heidi; Madsbad, Sten

    2007-01-01

    associated with LBW. DESIGN AND SUBJECTS: Vastus lateralis muscle was obtained by percutaneous biopsy from 20 healthy 19-yr-old men with birth weights at 10th percentile or lower for gestational age (LBW) and 20 normal birth weight controls, matched for body fat, physical fitness, and whole-body glucose...

  11. The effects of induced hypogonadism on arterial stiffness, body composition, and metabolic parameters in males with prostate cancer.

    Science.gov (United States)

    Smith, J C; Bennett, S; Evans, L M; Kynaston, H G; Parmar, M; Mason, M D; Cockcroft, J R; Scanlon, M F; Davies, J S

    2001-09-01

    Sex hormones appear to play a pivotal role in determining cardiovascular risk. Androgen deprivation therapy for males with prostate cancer results in a hypogonadal state that may have important, but as yet undetermined, effects on the vasculature. We studied the effects of androgen deprivation therapy on large artery stiffness in 22 prostate cancer patients (mean age, 67 +/- 8 yr) over a 6-month period. Arterial stiffness was assessed using pulse-wave analysis, a technique that measures peripheral arterial pressure waveforms and generates corresponding central aortic waveforms. This allows determination of the augmentation of central pressure resulting from wave reflection and the augmentation index, a measure of large artery stiffness. Body compositional changes were assessed using bioelectrical impedance analysis. Fasting lipids, glucose, insulin, testosterone, and estradiol were measured. After a 3-month treatment period, the augmentation index increased from 24 +/- 6% (mean +/- SD) at baseline to 29 +/- 9% (P = 0.003) despite no change in peripheral blood pressure. Timing of wave reflection was reduced from 137 +/- 7 to 129 +/- 10 msec (P = 0.003). Fat mass increased from 20.2 +/- 9.4 to 21.9 +/- 9.6 kg (P = 0.008), whereas lean body mass decreased from 63.2 +/- 6.8 to 61.5 +/- 6.0 kg (P = 0.016). There were no changes in lipids or glucose during treatment. Median serum insulin rose from 11.8 (range, 5.6-49.1) to 15.1 (range, 7.3-83.2) mU/liter at 1 month (P = 0.021) and to 19.3 (range, 0-85.0 mU/liter by 3 months (P = 0.020). There was a correlation between the changes in fat mass and insulin concentration over the 3-month period (r = 0.56; P = 0.013). In a subgroup of patients whose treatment was discontinued after 3 months, the augmentation index decreased from 31 +/- 7% at 3 months to 29 +/- 5% by 6 months, in contrast to patients receiving continuing treatment in whom the augmentation index remained elevated at 6 months compared with baseline (P = 0

  12. Body composition and diet of Chinese, Malays and Indians in Sininfluence on cardiovascular risk factorsgapore: and their

    NARCIS (Netherlands)

    Deurenberg-Yap, M.

    2000-01-01

    This thesis describes the studies on body composition and dietary intakes of the three major ethnic groups residing in Singapore, and how these are related to cardiovascular risk factors in these groups.

    Body composition : Body fat percentage was measu

  13. Body composition and diet of Chinese, Malays and Indians in Sininfluence on cardiovascular risk factorsgapore: and their

    NARCIS (Netherlands)

    Deurenberg-Yap, M.

    2000-01-01

    This thesis describes the studies on body composition and dietary intakes of the three major ethnic groups residing in Singapore, and how these are related to cardiovascular risk factors in these groups.

    Body composition : Body fat percentage was

  14. Body size, body composition and fat distribution: comparative analysis of European, Maori, Pacific Island and Asian Indian adults.

    Science.gov (United States)

    Rush, Elaine C; Freitas, Ismael; Plank, Lindsay D

    2009-08-01

    Although there is evidence that Asian Indians, Polynesians and Europeans differ in their body fat (BF)-BMI relationships, detailed comparative analysis of their underlying body composition and build characteristics is lacking. We investigated differences in the relationships between body fatness and BMI, fat distribution, muscularity, bone mineral mass, leg length and age-related changes in body composition between these ethnic groups. Cross-sectional analysis of 933 European, Maori, Pacific Island and Asian Indian adult volunteers was performed for total and percentage of BF, abdominal fat, thigh fat, appendicular muscle mass, bone mineral content and leg length measured by dual-energy X-ray absorptiometry. Asian Indian men and women (BMI of 24 and 26 kg/m2, respectively) had the same percentage of BF as Europeans with a BMI of 30 kg/m2 or Pacific men and women with BMI of 34 and 35 kg/m2, respectively. Asian Indians had more fat, both total and in the abdominal region, with less lean mass, skeletal muscle and bone mineral than all other ethnic groups. Leg length was relatively longer in Pacific men and Asian and Pacific women than in other ethnic groups. In Asian Indians, abdominal fat increased with increasing age, while the percentage of BF showed little change. In the other ethnic groups, both abdominal and total BF increased with age. In conclusion, ethnic differences in fat distribution, muscularity, bone mass and leg length may contribute to ethnic-specific relationships between body fatness and BMI. The use of universal BMI cut-off points may not be appropriate for the comparison of obesity prevalence between ethnic groups.

  15. Relation between body composition at birth and child development at 2 years of age

    DEFF Research Database (Denmark)

    Abera, Mubarek; Tesfaye, Markos; Girma, Tsinuel

    2017-01-01

    -displacement plethysmography. Child development was assessed at 2 years of age using Denver developmental screening test. Associations between body composition at birth and development at 2 years of age were tested using linear regression analysis. RESULTS: FFM but not FM at birth was positively associated with higher global...... (FFM) at birth. This study therefore aimed at investigating the relation between body composition at birth and child development at 2 years of age. SUBJECTS/METHODS: An Ethiopian birth cohort was followed up at 2 years. Body composition was measured within 48 h of birth using infant air......BACKGROUND/OBJECTIVES: Birth weight (BW), independent of socioeconomic status, has been identified as a predictor for childhood cognitive development. However, it is not known whether this relation is related to low BW per se or particularly related to a deficit in fat mass (FM) or fat-free mass...

  16. A study of apatite formation on natural nano-hydroxyapatite/ chitosan composite in simulated body fluid

    Institute of Scientific and Technical Information of China (English)

    Yong-bin FAN; Xiao-ying L(U)

    2008-01-01

    This study is focused on the ability of apatite formation on the surface of nano-hydroxyapatite (HA)/chitosan (CH) composite in simulated body fluid (SBF) in vitro. At first, natural nano-HA was prepared according to a wet-bailing method and the composite was prepared by combining the natural nano-hydroxyapatite and chit-osan, and then in vitro biomineralization test of natural nano-HA/CH composite was carried out in standard SBF. Subsequently, the quantity of the weight of the particles formed on the composite surface in SBF was measured by analytical balance, and the morphology change on the surface of the composite was observed by a scanning elec-tron microscope (SEM). Lastly, a Fourier transform infrared spectroscope (FTIR) was used to investigate the chemical components of the particles formed on the nat-ural nano-HA/CH composite surface in SBF. The result of quantity assessment shows that the weight of the com-posite increased with the increase of soaking time. The SEM image shows that the particles were gradually formed on natural nano-HA/CH composite surface, and the FTIR spectrum of the particles on composite surface confirms that these particles were carbonate apatite. This study indicates that the nano-HA/CH composite has a good ability for apatite formation in SBF, which predicts the bone-inducing ability of natural nano-HA/CH com-posite in vivo.

  17. Whole Body Computed Tomography with Advanced Imaging Techniques: A Research Tool for Measuring Body Composition in Dogs

    Directory of Open Access Journals (Sweden)

    Dharma Purushothaman

    2013-01-01

    Full Text Available The use of computed tomography (CT to evaluate obesity in canines is limited. Traditional CT image analysis is cumbersome and uses prediction equations that require manual calculations. In order to overcome this, our study investigated the use of advanced image analysis software programs to determine body composition in dogs with an application to canine obesity research. Beagles and greyhounds were chosen for their differences in morphology and propensity to obesity. Whole body CT scans with regular intervals were performed on six beagles and six greyhounds that were subjected to a 28-day weight-gain protocol. The CT images obtained at days 0 and 28 were analyzed using software programs OsiriX, ImageJ, and AutoCAT. The CT scanning technique was able to differentiate bone, lean, and fat tissue in dogs and proved sensitive enough to detect increases in both lean and fat during weight gain over a short period. A significant difference in lean : fat ratio was observed between the two breeds on both days 0 and 28 (P<0.01. Therefore, CT and advanced image analysis proved useful in the current study for the estimation of body composition in dogs and has the potential to be used in canine obesity research.

  18. A V2O3-ordered mesoporous carbon composite with novel peroxidase-like activity towards the glucose colorimetric assay

    Science.gov (United States)

    Han, Lei; Zeng, Lingxing; Wei, Mingdeng; Li, Chang Ming; Liu, Aihua

    2015-07-01

    It is of great scientific and practical significance to explore inorganic mimetic enzymes to replace natural enzymes due to their instability and high cost. Herein we present an interesting discovery that a V2O3-ordered mesoporous carbon composite (V2O3-OMC) has a novel peroxidase-like activity towards fast redox reaction of typical peroxidase substrates H2O2 and 2,2'-azino-bis(3-ethylbenzo-thiazoline-6-sulfonic acid) diammonium salt (ABTS). Due to the small size effect and large surface area of V2O3 nanoparticles supported by OMC, V2O3-OMC exhibited excellent catalytic performance with a kcat of 1.28 × 104 s-1, KM (ABTS) of 0.067 mM and KM (H2O2) of 0.16 mM, and a significantly higher catalytic efficiency (kcat/KM) towards the oxidation of ABTS in comparison with the natural peroxidases. Furthermore, the Ping-pong BiBi mechanism was proposed to explain the catalytic reaction by V2O3-OMC. Based on this highly active biomimetic peroxidase and the colorimetric detection of H2O2, a facile analytical method was developed to detect glucose by using V2O3-OMC and glucose oxidase, which had a wide linear range (0.01-4 mM glucose), good selectivity and reliability for successful detection of various real samples. Thus, the novel V2O3-OMC peroxidase mimetic holds great promise for broad potential applications.It is of great scientific and practical significance to explore inorganic mimetic enzymes to replace natural enzymes due to their instability and high cost. Herein we present an interesting discovery that a V2O3-ordered mesoporous carbon composite (V2O3-OMC) has a novel peroxidase-like activity towards fast redox reaction of typical peroxidase substrates H2O2 and 2,2'-azino-bis(3-ethylbenzo-thiazoline-6-sulfonic acid) diammonium salt (ABTS). Due to the small size effect and large surface area of V2O3 nanoparticles supported by OMC, V2O3-OMC exhibited excellent catalytic performance with a kcat of 1.28 × 104 s-1, KM (ABTS) of 0.067 mM and KM (H2O2) of 0.16 mM, and a

  19. Body composition, symptoms, and survival in advanced cancer patients referred to a phase I service.

    Directory of Open Access Journals (Sweden)

    Henrique A Parsons

    Full Text Available BACKGROUND: Body weight and body composition are relevant to the outcomes of cancer and antineoplastic therapy. However, their role in Phase I clinical trial patients is unknown. METHODS: We reviewed symptom burden, body composition, and survival in 104 patients with advanced cancer referred to a Phase I oncology service. Symptom burden was analyzed using the MD Anderson Symptom Assessment Inventory(MDASI; body composition was evaluated utilizing computerized tomography(CT images. A body mass index (BMI≥25 kg/m² was considered overweight. Sarcopenia, severe muscle depletion, was assessed using CT-based criteria. RESULTS: Most patients were overweight (n = 65, 63%; 53 patients were sarcopenic (51%, including 79% of patients with a BMI<25 kg/m² and 34% of those with BMI≥25 kg/m². Sarcopenic patients were older and less frequently African-American. Symptom burden did not differ among patients classified according to BMI and presence of sarcopenia. Median (95% confidence interval survival (days varied according to body composition: 215 (71-358 (BMI<25 kg/m²; sarcopenic, 271 (99-443 (BMI<25 kg/m²; non-sarcopenic, 484 (286-681 (BMI≥25 kg/m²; sarcopenic; 501 d (309-693 (BMI≥25 kg/m²; non-sarcopenic. Higher muscle index and gastrointestinal cancer diagnosis predicted longer survival in multivariate analysis after controlling for age, gender, performance status, and fat index. CONCLUSIONS: Patients referred to a Phase I clinic had a high frequency of sarcopenia and a BMI≥25 kg/m², independent of symptom burden. Body composition variables were predictive of clinically relevant survival differences, which is potentially important in developing Phase I studies.

  20. Relation between Lifestyle and Socio-Demographic Factors and Body Composition among the Elderly.

    Science.gov (United States)

    Zeinali, Fahime; Habibi, Nahal; Samadi, Mehnoosh; Azam, Kamal; Djafarian, Kurosh

    2016-08-01

    Aging is accompanied by various changes that can cause changes in diet and body composition resulting sometimes in malnutrition and disability in the elderly. Changes in body composition among the elderly are mainly the result of physical inactivity and nutrition. This study was designed to examine the relationship between lifestyle and socio-demographic factors and body composition. A cross-sectional study was carried out with 380 elderly people aged 60 and over in district 5 of Tehran, Iran. Their body composition was measured by Bioelectrical Impedance Analysis and the Actigraph device was used for assessing physical activity patterns. A three-day food recall was conducted to measure their intake of energy and macronutrients. Lifestyle and socio-demographic information were collected by interview using a pretested questionnaire. Overweight, obesity and central obesity were more prevalent in women than in men (p<0.001). Moreover, 57.1% and 18.7% of participants had high and very high fat mass index, respectively. High fat mass index was seen in 47% of men and 37.5% of women who had normal body mass index (BMI). Meanwhile, age, gender, physical activity, energy intake, the percentage of energy from fat and protein, educational level, job, television watching time, smoking, chronic diseases, and taking medicine were significantly associated with anthropometric measurements (p<0.05). Overweight, obesity and high body fat percentage were common among the aged. Considering the factors that are significantly associated with body composition, programs that can increase their awareness about the dietary balance and suitable physical activity should be organized to address these problems.

  1. Do differences in chemical composition of stem and cap of Amanita muscaria fruiting bodies correlate with topsoil type?

    Directory of Open Access Journals (Sweden)

    Stanisław Deja

    Full Text Available Fly agaric (Amanita muscaria was investigated using a 1H NMR-based metabolomics approach. The caps and stems were studied separately, revealing different metabolic compositions. Additionally, multivariate data analyses of the fungal basidiomata and the type of soil were performed. Compared to the stems, A. muscaria caps exhibited higher concentrations of isoleucine, leucine, valine, alanine, aspartate, asparagine, threonine, lipids (mainly free fatty acids, choline, glycerophosphocholine (GPC, acetate, adenosine, uridine, 4-aminobutyrate, 6-hydroxynicotinate, quinolinate, UDP-carbohydrate and glycerol. Conversely, they exhibited lower concentrations of formate, fumarate, trehalose, α- and β-glucose. Six metabolites, malate, succinate, gluconate, N-acetylated compounds (NAC, tyrosine and phenylalanine, were detected in whole A. muscaria fruiting bodies but did not show significant differences in their levels between caps and stems (P value>0.05 and/or OPLS-DA loading correlation coefficient <0.4. This methodology allowed for the differentiation between the fruiting bodies of A. muscaria from mineral and mineral-organic topsoil. Moreover, the metabolomic approach and multivariate tools enabled to ascribe the basidiomata of fly agaric to the type of topsoil. Obtained results revealed that stems metabolome is more dependent on the topsoil type than caps. The correlation between metabolites and topsoil contents together with its properties exhibited mutual dependences.

  2. Assessment of nutritional status, body composition, and human immunodeficiency virus-associated morphologic changes.

    Science.gov (United States)

    Knox, Tamsin A; Zafonte-Sanders, Melissa; Fields-Gardner, Cade; Moen, Karol; Johansen, Diana; Paton, Nicholas

    2003-04-01

    Nutritional status should be assessed at regular intervals as part of management of human immunodeficiency virus (HIV) infection. The simplest approach to assessment is serial weight measurement. A comprehensive nutritional assessment includes (1) anthropometric measurements of body composition; (2) biochemical measurements of serum protein, micronutrients, and metabolic parameters; (3) clinical assessment of altered nutritional requirements and social or psychological issues that may preclude adequate intake; and (4) measurement of dietary intake. Techniques for measuring body composition of fat and lean body mass include anthropometry and bioelectric impedance analysis. Other techniques, including dual X-ray absorptiometry (DXA), hydrodensitometry, total body potassium measurement, and cross-sectional computed tomography or magnetic resonance imaging are available in research centers. Anthropometry, including waist-hip ratios, regional DXA, and cross-sectional imaging, is best for detecting morphologic changes associated with fat redistribution syndrome. Nutritional assessment and intervention in children with HIV can help to prevent stunted growth and development.

  3. Body composition in affective disorder before, during, and after lithium carbonate therapy.

    Science.gov (United States)

    Colt, E W; Dunner, D L; Wang, J; Ross, D C; Pierson, R N; Fieve, R R

    1982-05-01

    The body composition of three unipolar and 17 bipolar patients, studied during the depressive state, was compared with that of 48 controls. The ratio of extracellular to intracellular water content was significantly less in male patients than in male controls: the difference between female patients and female controls was not statistically significant. In patients of both sexes, residual sodium concentration was greater in patients than in controls. The intracellular content of potassium was the same in patients as in controls. In six patients, body composition was studied prior to lithium carbonate therapy, after 17 days of treatment, and 17 days after discontinuing administration of the drug. The significant changes were a decrease in body weight during therapy, and a decrease in body water content and an increase in residual sodium concentration after drug treatment was discontinued.

  4. A new air displacement plethysmograph for the determination of Japanese body composition.

    Science.gov (United States)

    Miyatake, N; Nonaka, K; Fujii, M

    1999-11-01

    A new device based on the plethysmographic measurement of body volume, named the BOD POD Body Composition System, was developed for the purpose of estimating body composition. The performance, reliability, validity, and clinical application of this system were evaluated in Japanese subjects. The coefficient variation (CV:%) in same-day tests was 2.48, in three separate-day tests it was 2.27, and for independent operators it was 4.53, respectively. There was a clear correlation between the results from BOD POD and those from dual energy X-ray absorptiometry (DEXA) (r = 0.910, p BOD POD. The findings indicate that the BOD POD is a highly reliable and valid method for determining body fat percentage. This new method has several advantages, e.g. it is quick, simple to operate and may accommodate wide populations.

  5. Effects of creatine supplementation on the performance and body composition of competitive swimmers.

    Science.gov (United States)

    Mendes, Renata Rebello; Pires, Ivanir; Oliveira, Althair; Tirapegui, Julio

    2004-08-01

    The objective of this study was to determine the effect of creatine supplementation on performance and body composition of swimmers. Eighteen swimmers were evaluated in terms of post-performance lactate accumulation, body composition, creatine and creatinine excretion, and serum creatinine concentrations before and after creatine or placebo supplementation. No significant differences were observed in the marks obtained in swimming tests after supplementation, although lactate concentrations were higher in placebo group during this period. In the creatine-supplemented group, urinary creatine, creatinine, and body mass, lean mass and body water were significantly increased, but no significant difference in muscle or bone mass was observed. These results suggest that creatine supplementation cannot be considered to be an ergogenic supplement ensuring improved performance and muscle mass gain in swimmers.

  6. Body composition in Pan paniscus compared with Homo sapiens has implications for changes during human evolution.

    Science.gov (United States)

    Zihlman, Adrienne L; Bolter, Debra R

    2015-06-16

    The human body has been shaped by natural selection during the past 4-5 million years. Fossils preserve bones and teeth but lack muscle, skin, fat, and organs. To understand the evolution of the human form, information about both soft and hard tissues of our ancestors is needed. Our closest living relatives of the genus Pan provide the best comparative model to those ancestors. Here, we present data on the body composition of 13 bonobos (Pan paniscus) measured during anatomical dissections and compare the data with Homo sapiens. These comparative data suggest that both females and males (i) increased body fat, (ii) decreased relative muscle mass, (iii) redistributed muscle mass to lower limbs, and (iv) decreased relative mass of skin during human evolution. Comparison of soft tissues between Pan and Homo provides new insights into the function and evolution of body composition.

  7. Seasonal changes in total body water; body composition and water turnover in reindeer

    Directory of Open Access Journals (Sweden)

    Terje S. Larsen

    1985-05-01

    Full Text Available Total body water and water turnover were measured at different times throughout the year in 3 captive Norwegian reindeer, using a tritiated water dilution method (Holleman et al. 1982. Total body water (percent of body weight increased during late autumn and winter, from 59.1 ± 1.5 % in October to 72.5 ± 2.0 % in April. Using the equatation by Pace and Rathbun (1945 for predicting total body fat (% fat = 100 - % water/0.732, this increase in total body water indicates a concomitant reduction in body fat, from a maximum value of 18.9 ± 2.6 % (of body weight in October to a minimum of 0.9 ± 2.7 % in April. During summer, on the other hand, fat content increased at the expense of a reduced percentage of body water. Water turnover was low in winter (December - April, ranging between 30.8 ± 5.2and43.6 ± 13.5ml.d-'. kg-1, but increased nearly fourfold during summer (June-August with a maximum of 117.7 ± 5.9 ml.d-1. kg-1 in August. Positive correlations between water turnover and food intake and between water turnover and ambient temperature were found, the latter probably resulting from an incidental correlation between food intake and ambient temperature.Sesongmessige forandringer i totalt kroppsvann, kropps-sammensetning og vannomsetning hos reinsdyr.Abstract in Norwegian / Sammendrag: Totalt kroppsvann og vannomsetning av vann ble målt til forskjellige årstider i 3 norske reinsdyr ved hjelp av utvasking av tritiert vann (Holleman et al. 1982. Totalt kroppsvann (prosent av kroppsvekt økte utover høsten og vinteren, fra 59.1 ± 1.5 % i oktober til 72.5 ± 2.0 % i april. Ved hjelp av en ligning som er gitt av Pace og Rathbun (1945 for beregning av totalt kroppsfett (% fett = 100 - % vann/0.732, fant en at denne økningen i vanninnhold tilsvarte en samtidig reduksjon i fettinnhold, fra en maksimums-verdi på 18.9 ± 2.6 % av kroppsvekt i oktober til et minimum på 0.9 ± 2.7 % i april. Utover sommeren økte derimot innholdet av fett p

  8. An interrelation of physical working capacity and body component composition indicators of amateur athletes

    Directory of Open Access Journals (Sweden)

    Zoya Gorenko

    2017-09-01

    Full Text Available Purpose: determine the features of the body component composition and the level of physical performance, as well as the structure of the correlation between these indicators in amateur athletes. Material & Methods: in conditions of the test with physical load with stepwise increasing power in the 71-st physically active person, the reaction of the cardio-respiratory system to physical activity. The body component composition was determined by the bioelectrical impedance method. Result: in amateur athletes, the relative VO2max and power ratings are positively correlated with the relative body water content and have a negative relationship with age, body weight, body mass index, fat content. Oxygen pulse with a high degree of probability positively correlated with body weight, body mass index, metabolic rate, fat-free mass, water content and predictable muscle mass in all body segments. Conclusion: Conducted studies indicate a sufficient level of aerobic capacity, overall performance, the efficiency of the cardiac cycle, the functioning of the О2-transport system and skeletal muscles ability to absorb oxygen from the amateur athletes, and excess fat tissue negatively affects physical performance, overall endurance and achieving high sports results in sports on the endurance.

  9. Noni-based nutritional supplementation and exercise interventions influence body composition

    Directory of Open Access Journals (Sweden)

    Afa K Palu

    2011-01-01

    Full Text Available Background: The prevalence of obesity and overweight in the Unites States has reached unprecedented levels, and so has the need for effective exercise and nutritional programs for prevention of unhealthy weight gain or safe weight loss. Aims: The present study was conducted in overweight men and women to assess the impact of noni-based nutritional supplementation and exercise interventions on body composition. Materials and Methods: Twenty two participants (16 women and 6 men, ages 18-65, were enrolled in a 12-week, open-label trial of a weight-loss program involving noni-based dietary supplements, gender-specific daily calorie restriction, and exercise interventions. Weight, percent body fat, and body mass index were measured before and after the trial. Results: All participants experienced weight loss. The average decrease in fat mass was highly significant (P < 0.0001, as were decreases in percent body fat and body mass index. Individual weight and fat mass losses were 17.55 ± 9.73 and 21.78 ± 8.34 lbs., respectively, and individual percent body fat and body mass index decreases were 8.91 ± 3.58 % and 2.6 ± 1.32, respectively. Conclusion: The nutritional and exercise interventions significantly influenced body composition among participants.

  10. Fitness, daily activity and body composition in children with newly diagnosed, untreated asthma

    DEFF Research Database (Denmark)

    Vahlkvist, S; Pedersen, S

    2009-01-01

    Background: Information about how the asthma disease affects the life style and health in children is sparse. Aim: To measure fitness, daily physical activity and body composition in children with newly diagnosed, untreated asthma and healthy controls, and to assess the association between...... the level of asthma control and these parameters. Methods: Daily physical activity measured using accelerometry, cardiovascular fitness and body composition (per cent fat, per cent lean tissue and bone mineral density) were measured in 57 children with newly diagnosed, untreated asthma and in 157 healthy...... fitness and daytime spent in intensive activity. Overweight children are physically less active than normal weight children....

  11. Deuterium dilution technique for body composition assessment: resolving methodological issues in children with moderate acute malnutrition

    DEFF Research Database (Denmark)

    Fabiansen, Christian; Yaméogo, Charles W; Devi, Sarita

    2017-01-01

    Childhood malnutrition is highly prevalent and associated with high mortality risk. In observational and interventional studies among malnourished children, body composition is increasingly recognised as a key outcome. The deuterium dilution technique has generated high-quality data on body...... composition in studies of infants and young children in several settings, but its feasibility and accuracy in children suffering from moderate acute malnutrition requires further study. Prior to a large nutritional intervention trial among children with moderate acute malnutrition, we conducted pilot work...... quality when using the deuterium dilution technique in malnutrition studies in field conditions, and may encourage a wider use of isotope techniques....

  12. Static and Dynamic Mechanical Behavior of Hydroxyapatite-Polyacrylic Acid Composites Under Simulated Body Fluid

    Directory of Open Access Journals (Sweden)

    Kalpana S. Katti

    2006-01-01

    Full Text Available In this work, we have investigated mechanical response of hydroxyapatite/polyacrylic composites under dry, wet and simulated body fluid conditions. Hydroxyapatite (HAP is mineralized under two conditions; one, in presence of polyacrylic acid (in situ HAP, second, in absence of polyacrylic acid (ex situ HAP. Further, in situ and ex situ HAP are mixed with polyacrylic acid to make HAP/PAAc composites. Interfacial interactions between PAAc and HAP have been studied using photoacoustic Fourier transform infrared spectroscopy (PAS-FTIR. The mechanical response of the composites under wet condition is studied by soaking composite samples in simulated body fluid (SBF. Under wet conditions, SBF and water weaken the HAP-HAP interface significantly. PAS-FTIR data suggests that PAAc attaches to HAP through the dissociated carboxylate groups. The water and SBF soaked samples showed creep-like behavior and exhibit large residual strain after unloading. Loading under different strain rates has significant effect on mechanical properties of these composites. Both in situ and ex situ 70:30 composites exhibit highest elastic modulus at strain rate of 0.01 sec-1. XRD study indicates formation of Ca2P2O7 phase in ex situ composite after soaking in SBF and water for 3 hours, whereas in situ composites showed presence of only hydroxyapatite phase after soaking in SBF and water for same duration of time.

  13. A V₂O₃-ordered mesoporous carbon composite with novel peroxidase-like activity towards the glucose colorimetric assay.

    Science.gov (United States)

    Han, Lei; Zeng, Lingxing; Wei, Mingdeng; Li, Chang Ming; Liu, Aihua

    2015-07-21

    It is of great scientific and practical significance to explore inorganic mimetic enzymes to replace natural enzymes due to their instability and high cost. Herein we present an interesting discovery that a V2O3-ordered mesoporous carbon composite (V2O3-OMC) has a novel peroxidase-like activity towards fast redox reaction of typical peroxidase substrates H2O2 and 2,2'-azino-bis(3-ethylbenzo-thiazoline-6-sulfonic acid) diammonium salt (ABTS). Due to the small size effect and large surface area of V2O3 nanoparticles supported by OMC, V2O3-OMC exhibited excellent catalytic performance with a k(cat) of 1.28 × 10(4) s(-1), K(M) (ABTS) of 0.067 mM and K(M) (H2O2) of 0.16 mM, and a significantly higher catalytic efficiency (k(cat)/K(M)) towards the oxidation of ABTS in comparison with the natural peroxidases. Furthermore, the Ping-pong BiBi mechanism was proposed to explain the catalytic reaction by V2O3-OMC. Based on this highly active biomimetic peroxidase and the colorimetric detection of H2O2, a facile analytical method was developed to detect glucose by using V2O3-OMC and glucose oxidase, which had a wide linear range (0.01-4 mM glucose), good selectivity and reliability for successful detection of various real samples. Thus, the novel V2O3-OMC peroxidase mimetic holds great promise for broad potential applications.

  14. REVIEW: A review of in vivo experimental methods to determine the composition of the human body

    Science.gov (United States)

    Sutcliffe, J. F.

    1996-05-01

    This review of experimental methods employed in the measurement of the composition of the human body covers the developments that have occurred over the past 30 years. Early methods such as hydrodensitometry and skinfold anthropometry have been superseded by dual-energy x-ray absorptiometry and bioelectrical impedance spectroscopy. The measurement of the whole-body abundance of certain elements by isotopic dilution, neutron activation analysis and x-ray fluorescence can give important information of clinical significance, but neutron activation facilities remain available in only a few centres worldwide. The relatively simple, rapid and risk-free electrical methods such as multifrequency bioelectrical impedance analysis, which can be employed at the bedside, have been found to be more complicated in their interpretation. Electromagnetic methods may only measure the composition of the human body at its surface. X-ray computed tomography and magnetic resonance imaging have not yet been employed much in body composition measurements. Some models for the composition of the human body are reviewed.

  15. Executive summary of the 2013 International Society for Clinical Densitometry Position Development Conference on Body Composition.

    Science.gov (United States)

    Shepherd, John A; Baim, Sanford; Bilezikian, John P; Schousboe, John T

    2013-01-01

    There have been many scientific advances in measurement of fat and lean body mass as determined by dual-energy X-ray absorptiometry (DXA). The International Society for Clinical Densitometry (ISCD) convened a Position Development Conference (PDC) on the use of DXA for body composition measurement. Previously, no guidelines to the use of DXA for body composition existed. The recommendations pertain to clinically relevant issues regarding DXA indications of use, acquisition, analysis, quality control, interpretation, and reporting were addressed. The topics and questions for consideration were developed by the ISCD Board of Directors and the Scientific Advisory Committee and were designed to address the needs of clinical practitioners. Three Task Forces were created and assigned these questions and asked to conduct comprehensive literature reviews. The Task Forces included participants from 6 countries and a variety of interests including academic institutions, private clinics, and industry. Reports with proposed Position Statements were then presented to an international panel of experts with backgrounds in DXA and bone densitometry and a variety of fields that use body composition measures. The PDC was held in Tampa, FL, contemporaneously with the Annual Meeting of the ISCD, March 21 through March 23, 2013. This report describes the methodology of the 2013 ISCD Body Composition PDC and summarizes the results. Three separate articles in this issue will detail the rationale, discussion, and additional research topics for each question the Task Forces addressed. Copyright © 2013 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved.

  16. Techniques of body composition assessment: a review of laboratory and field methods.

    Science.gov (United States)

    Wagner, D R; Heyward, V H

    1999-06-01

    Body composition is one of the major health-related components of fitness. Thus, it is important for health and fitness professionals to have a general understanding of the most commonly used techniques for assessing body composition. This review presents the developmental background and underlying principles and theory of four laboratory (hydrodensitometry, air displacement plethysmography, isotope dilution, and dual-energy x-ray absorptiometry) and four field (bioelectrical impedance analysis, near-infrared interactance, skinfolds, and anthropometry) methods of body composition assessment. In addition to a description of the methods, the validity, and reliability, strengths, and limitations of each measurement tool are examined. Highlights of the laboratory methods include the relatively new Bod Pod air displacement device, which is a promising assessment tool more convenient than hydrodensitometry but still lacking substantial validity testing and the ability of dual-energy x-ray absorptiometry to measure regional composition making it an attractive method for clinicians. Advancements in segmental and multifrequency bioelectrical impedance for compartmental analysis have enhanced the value of this field method, but research continues to show that commercially available near-infrared interactance units are invalid. With this knowledge, the clinician and researcher should be able to make an informed decision regarding the most appropriate measurement device for their body composition assessments.

  17. Body composition measurement in African and Caribbean children and its relationship with morbidity

    OpenAIRE

    Amoako-Attah, Eva

    2015-01-01

    The global increase in obesity prevalence has led to a surge in metabolic disease in both adults and children. Furthermore, the burden of obesity and its related morbidities is not equally distributed across the UK population, with those from minority ethnic groups particularly affected. Effective paediatric epidemiological monitoring and clinical referral requires improved tools for assessing body fatness, and other body composition measures related to metabolic disease are needed. Presently...

  18. A review on effects of conjugated linoleic fatty acid (CLA) upon body composition and energetic metabolism

    OpenAIRE

    Lehnen, Tatiana Ederich; da Silva, Marcondes Ramos; Camacho, Augusto; Marcadenti, Aline; Lehnen, Alexandre Machado

    2015-01-01

    Conjugated linoleic acid (CLA) is highly found in fats from ruminants and it appears to favorably modify the body composition and cardiometabolic risk factors. The capacity of CLA to reduce the body fat levels as well as its benefic actions on glycemic profile, atherosclerosis and cancer has already been proved in experimental models. Furthermore, CLA supplementation may modulate the immune function, help re-synthetize of glycogen and potentiate the bone mineralization. CLA supplementation al...

  19. Comparison of ultrasonography and skinfold measurements of subcutaneous fat thickness in the evaluation of body composition

    OpenAIRE

    Akyer, Şahika Pınar; Adıgüzel, Esat; Sabir, Nuran; Akdoğan, Ilgaz; Yılmaz, Birsen; yonguç, gökşin nilüfer

    2014-01-01

    Objectives:To determine the amount of body fat tissue with skinfold thickness measurements is a common method to estimate the body composition. The other method used for this purpose is ultrasonography which is expensive and needs specialization to apply. In this study, validity of skinfold thickness measurements was investigated using ultrasonography. Methods: One hundred adult volunteers (50 males and 50 females) were used in this study. The ages of the subjects were 20to 70, selected as10 ...

  20. Body composition in obstructive sleep apneahypopnea syndrome bio-impedance reflects the severity of sleep apnea

    Directory of Open Access Journals (Sweden)

    Lovin Sînziana

    2010-02-01

    Full Text Available Abstract Background Obstructive sleep apnea-hypopnea syndrome (OSAHS is characterized by repeated breathing pauses during sleep and is closely associated with obesity. Body fat is known to be a predictive factor for OSAHS and its severity. Aim To study the correlation between the severity of OSAHS and body composition measurements. Methods 30 patients with OSAHS (21 men, 9 women, mean age 45.1 years, mean apnea-hypopnea index = 29.6/hour were included in the study after full polysomnography. They were divided into 3 groups according to the apnea-hypopnea index (AHI: mild OSAHS (mean AHI 10.9/h, moderate OSAHS (mean AHI 23.9/h and severe OSAHS (mean AHI 53.9/h. Body composition (body fat, body water and dry lean mass was assessed using bioelectric impedance assay (BIA. Other measurements included neck and abdominal circumferences and body mass index (BMI. Pearson's coefficient (r was used to express correlations between AHI and the following parameters: BMI, neck and abdominal circumferences, body fat, dry lean mass, and body water. Wilcoxon Sum-of-Ranks (Mann-Whitney test for comparing unmatched samples was used to compare anthropometric and body composition measurements between groups. Results The correlation between AHI and BMI was weak (r = 0.38. AHI correlated moderately with neck circumference (r = 0.54, with neck circumference corrected by height (r = 0.60, and more strongly with body fat (r = 0.67, with body water (r = 0.69 and with abdominal circumference (r = 0.75. There was a strong negative correlation between AHI and dry lean mass (r = - 0.92. There were significant differences in body fat, body water, neck circumference corrected by height and abdominal circumference (Wilcoxon Sum-of-Ranks, p Conclusions In our study, the severity of OSAHS correlated with body fat and with body water more strongly than with general and cervical obesity. Abdominal adiposity may predict OSAHS severity better than neck circumference.

  1. Reduced graphene oxide-nickel nanoparticles/biopolymer composite films for the sub-millimolar detection of glucose.

    Science.gov (United States)

    Krishna, Rahul; Campiña, José M; Fernandes, Paula M V; Ventura, João; Titus, Elby; Silva, António F

    2016-06-20

    Hybrid conjugates of graphene with metallic/semiconducting nanostructures can improve the sensitivity of electrochemical sensors due to their combination of well-balanced electrical/electrocatalytic properties and superior surface-to-volume ratio. In this study, the synthesis and physical characterization of a hybrid conjugate of reduced graphene oxide and nickel nanoparticles (rGO-Ni NPs) is presented. The conjugate was further deposited onto a glassy carbon electrode as a nanocomposite film of chitosan and glucose oxidase. The electrochemical response and morphology of the films were investigated using SEM, CV, and EIS, and their applications as a glucose biosensor explored for the first time in proof-of-concept tests. The low operating potential along with the good linearity and sensitivity (up to 129 μA cm(-2) mM(-1)) found in the sub-millimolar range suggest potential applications in the self-management of hypoglycemia from blood samples or in the development of non-invasive assays for body fluids such as saliva, tears or breath.

  2. Effects of programmed physical activity on body composition in post-pubertal schoolchildren.

    Science.gov (United States)

    Farias, Edson Dos Santos; Gonçalves, Ezequiel Moreira; Morcillo, André Moreno; Guerra-Júnior, Gil; Amancio, Olga Maria Silverio

    2015-01-01

    To assess body composition modifications in post-pubertal schoolchildren after practice of a physical activity program during one school year. The sample consisted of 386 students a