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Sample records for blood gas analysis

  1. Blood gas analysis for bedside diagnosis

    OpenAIRE

    Singh, Virendra; Khatana, Shruti; Gupta, Pranav

    2013-01-01

    Arterial blood gas is an important routine investigation to monitor the acid-base balance of patients, effectiveness of gas exchange, and the state of their voluntary respiratory control. Majority of the oral and maxillofacial surgeons find it difficult to interpret and clinically correlate the arterial blood gas report in their everyday practice. This has led to underutilization of this simple tool. The present article aims to simplify arterial blood gas analysis for a rapid and easy bedside...

  2. Analysis of blood gas values in mice following pulmonary irradiation

    International Nuclear Information System (INIS)

    The arterial pH and partial pressures of oxygen (P/sub a/O2) and carbon dioxide (P/sub a/CO2) of mice were investigated at times from 1 to 16 weeks after a single radiation dose of 1100 rad to the thorax. The mice breathed air during the irradiation and either air, 7% O2:93% N2, or 100% O2 during the blood gas determinations. P/sub a/O2 values of mice breathing 7% O2:93% N2 or 100% O2 were reduced 4 to 6 weeks after the irradiation. Also, all P/sub a/O2 values were reduced and all hemoglobin (Hb) levels were elevated 16 weeks after irradiation. The majority of the animals died between 16 and 26 weeks after irradiation, but decreased P/sub a/O2 and increased Hb levels also were observed 27 weeks after the treatment in a few of the surviving mice. These findings indicate that the arterial blood gases may change following pulmonary irradiation and may provide an endpoint for the study of radiation-induced pulmonary damage

  3. Arterial blood gas analysis and electrolyte determination in neonates with asphyxia

    Institute of Scientific and Technical Information of China (English)

    Zi-Mei Sun

    2015-01-01

    Objective:To explore the value of arterial blood gas analysis and electrolyte determination in the diagnosis of neonatal asphyxia.Methods: A total of 100 neonates with asphyxia who were admitted in our department from March, 2013 to March, 2014 were included in the study and divided into the mild asphyxia group and the severe asphyxia group according to Apgar scoring. Moreover, 50 normal neonates were served as the control group and used for comparative analysis. AVL blood-gas analyzer was used to detect the levels of pH, PaO2, HCO3-, BE, PaCO2, K+, Na+, Cl-, and Ca2+.Results:The concentrations of pH, PaO2, HCO3-, and BE in the severe asphyxia group were significantly lower than those in the mild asphyxia group and the control group, while PaCO2 level was significantly higher than that in the mild asphyxia group and the control group. The comparison of the various indicators between the control group and the mild asphyxia group was not statistically significant. The comparison of serum K+, Na+,and Cl- levels among the control group, the mild asphyxia group, and the severe asphyxia group was not statistically significant. The serum Ca2+ level in the severe asphyxia group was significantly lower than that in the mild asphyxia group and the control group, while the comparison between the mild asphyxia group and the control group was also statistically significant.Conclusions:Blood gas analysis and electrolyte determination to the arterial blood in neonates can compensate for the insufficiency of Apgar scoring and provide an objective evidence for the diagnosis of neonatal asphyxia and the estimation of severity degree. Clinical combination with Apgar scoring is of great significance in enhancing the diagnosis of neonatal asphyxia and the accuracy of severity evaluation.

  4. Arterial blood gas analysis or oxygen saturation in the assessment of acute asthma?

    OpenAIRE

    Carruthers, D M; Harrison, B. D.

    1995-01-01

    BACKGROUND--A study was undertaken to determine if arterial blood gas estimation is always necessary in the assessment of patients presenting to hospital with acute severe asthma, or whether oxygen saturation as measured by pulse oximetry is a reliable screening test for predicting those in respiratory failure. METHODS--A prospective study was conducted in a specialist respiratory medical unit. Arterial blood gas tensions and pulse oximetry were measured in 89 consecutive patients admitted wi...

  5. Optical Transcutaneous pCO2 Sensor using Soft Lithography Method for Arterial Blood Gas Analysis

    Science.gov (United States)

    Kang, Byoung-Ho; Kim, Do-Eok; Leem, Myoung-Kun; Kwon, Dae-Hyuk; Lee, Kwang-Man; Kang, Shin-Won

    2008-10-01

    In this study, we carried out development of non-invasive optical transcutaneous partial pressure of carbon dioxide, pCO2, monitoring system. The purpose of this system is to detect CO2 from outer skin, not from the arterial blood-gathering method. There are advantages about a reduction of analysis time and real-time monitoring that this system might be available. The measurement system is composed of the IR lamp, the pyroelectric sensor including a 4.26 μm optical filter, the optical gas reaction chamber and the signal processing circuit. The optical reaction length of chamber was reduced by 1 mm using the soft-lithography method which CO2 is exhausted in human body as we considered. The fabricated pCO2 monitoring system showed linear result of 6.50×10-6 absorbance/ppm sensitivity for CO2 concentration from 0 ˜5,000 ppm by MFC and about 2 seconds of fast response time. The proposed system can be used in the optical biosensor field for the medical diagnosis such as pCO2 monitoring system and environment monitoring systems.

  6. Clinical significance of blood gas and electrolyte analysis, CK, CK-MB and HBDH changes in neonatal asphyxia

    Institute of Scientific and Technical Information of China (English)

    Bao-Hua Xu; Xin Lin; Mi-Jia Huang

    2016-01-01

    Objective:To investigate the clinical significance of blood gas and electrolyte analysis, CK, CK-MB and HBDH changes in neonatal asphyxia.Methods:A total of 100 newborns with asphyxia who visited in our hospital were collected, and divided into severe group (n=20) and mild group (n=80) according to the asphyxia degree, and 50 healthy newborns regarded as control group. The 3 groups received blood gas analysis (pH, BE and PaCO2), electrolyte (K+, Na+ and Ca2+) and 3 kinds of enzymes (CK, CK-MB and HBDH) were tested and compared.Results: Compared with control group, pH and BE of blood gas indexes decreased significantly and PaCO2 increased significantly in severe group (P0.05). Compared with mild group, pH and BE of blood gas indexes decreased significantly and PaCO2 increased significantly in severe group (P0.05). Compared with mild group, the level of Ca2+ decreased significantly in severe group (P<0.05); Compared with control group, the levels of CK, CK-MB and HBDH increased significantly in severe and mild group (P<0.05). Compared with mild group, the levels of CK, CK-MB and HBDH increased significantly in severe group (P<0.05).Conclusions:The detection of blood gas and electrolyte analysis, CK, CK-MB and HBDH can provide an objective evidence for the diagnosis of neonatal asphyxia and estimation of severity degree which was helpful in clinical treatment.

  7. The role of pre-hospital blood gas analysis in trauma resuscitation

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    Katila Ari

    2010-04-01

    Full Text Available Abstract Background To assess, whether arterial blood gas measurements during trauma patient's pre-hospital shock resuscitation yield useful information on haemodynamic response to fluid resuscitation by comparing haemodynamic and blood gas variables in patients undergoing two different fluid resuscitation regimens. Methods In a prospective randomised study of 37 trauma patients at risk for severe hypovolaemia, arterial blood gas values were analyzed at the accident site and on admission to hospital. Patients were randomised to receive either conventional fluid therapy or 300 ml of hypertonic saline. The groups were compared for demographic, injury severity, physiological and outcome variables. Results 37 patients were included. Mean (SD Revised Trauma Score (RTS was 7.3427 (0.98 and Injury Severity Score (ISS 15.1 (11.7. Seventeen (46% patients received hypertonic fluid resuscitation and 20 (54% received conventional fluid therapy, with no significant differences between the groups concerning demographic data or outcome. Base excess (BE values decreased significantly more within the hypertonic saline (HS group compared to the conventional fluid therapy group (mean BE difference -2.1 mmol/l vs. -0.5 mmol/l, p = 0.003. The pH values on admission were significantly lower within the HS group (mean 7.31 vs. 7.40, p = 0.000. Haemoglobin levels were in both groups lower on admission compared with accident site. Lactate levels on admission did not differ significantly between the groups. Conclusion Pre-hospital use of small-volume resuscitation led to significantly greater decrease of BE and pH values. A portable blood gas analyzer was found to be a useful tool in pre-hospital monitoring for trauma resuscitation.

  8. Correlation between arterial and venous blood gas analysis parameters in patients with acute exacerbation of chronic obstructive pulmonary disease

    OpenAIRE

    Novović Miloš; Topić Vesna

    2012-01-01

    Introduction. Arterial blood gas (ABG) analyses have an important role in the assessment and monitoring of the metabolic and oxygen status of patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Arterial puncture could have a lot of adverse effects, while sampling of venous blood is simpler and is not so invasive. Objective. The aim of this study was to evaluate whether venous blood gas (VBG) values of pH, partial pressure of carbon dioxide (PCO2), partial o...

  9. Correlation between arterial and venous blood gas analysis parameters in patients with acute exacerbation of chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Novović Miloš

    2012-01-01

    Full Text Available Introduction. Arterial blood gas (ABG analyses have an important role in the assessment and monitoring of the metabolic and oxygen status of patients with acute exacerbation of chronic obstructive pulmonary disease (COPD. Arterial puncture could have a lot of adverse effects, while sampling of venous blood is simpler and is not so invasive. Objective. The aim of this study was to evaluate whether venous blood gas (VBG values of pH, partial pressure of carbon dioxide (PCO2, partial oxygen pressure (PO2, bicarbonate (HCO3, and venous and arterial blood oxygen saturation (SO2 can reliably predict ABG levels in patients with acute exacerbation of COPD. Methods. Forty-seven patients with a prior diagnosis of COPD were included in this prospective study. The patients with acute exacerbation of this disease were examined at the General Hospital EMS Department in Prijepolje. ABG samples were taken immediately after venous sampling, and both were analyzed. Results. The Pearson correlation coefficients between arterial and venous parameters were 0.828, 0.877, 0.599, 0.896 and 0.312 for pH, PCO2, PO2, HCO3 and SO2, respectively. The statistically significant correlation between arterial and venous pH, PCO2 and HCO3, values was found in patients with acute exacerbation of COPD (p<0.001. Conclusion. When we cannot provide arterial blood for analysis, venous values of the pH, Pv,CO2 and HCO3 parameters can be an alternative to their arterial equivalents in the interpretation of the metabolic status in patients with acute exacerbation of COPD, while the values of venous Pv,O2 and Sv,O2 cannot be used as predictors in the assessment of oxygen status of such patients.

  10. Fast gas chromatography and negative-ion chemical ionization tandem mass spectrometry for forensic analysis of cannabinoids in whole blood.

    Science.gov (United States)

    Thomas, Aurélien; Widmer, Christèle; Hopfgartner, Gérard; Staub, Christian

    2007-11-01

    The present work describes a fast gas chromatography/negative-ion chemical ionization tandem mass spectrometric assay (Fast GC/NICI-MS/MS) for analysis of tetrahydrocannabinol (THC), 11-hydroxy-tetrahydrocannabinol (THC-OH) and 11-nor-9-carboxy-tetrahydrocannabinol (THC-COOH) in whole blood. The cannabinoids were extracted from 500 microL of whole blood by a simple liquid-liquid extraction (LLE) and then derivatized by using trifluoroacetic anhydride (TFAA) and hexafluoro-2-propanol (HFIP) as fluorinated agents. Mass spectrometric detection of the analytes was performed in the selected reaction-monitoring mode on a triple quadrupole instrument after negative-ion chemical ionization. The assay was found to be linear in the concentration range of 0.5-20 ng/mL for THC and THC-OH, and of 2.5-100 ng/mL for THC-COOH. Repeatability and intermediate precision were found less than 12% for all concentrations tested. Under standard chromatographic conditions, the run cycle time would have been 15 min. By using fast conditions of separation, the assay analysis time has been reduced to 5 min, without compromising the chromatographic resolution. Finally, a simple approach for estimating the uncertainty measurement is presented. PMID:17913432

  11. Computed tomography and blood gas analysis of anesthetized bloodhounds with induced pneumothorax

    International Nuclear Information System (INIS)

    Increasingly severe degrees of pneumothorax were produced in 6 adult anesthetized bloodhounds. Computed tomography (CT) of the thorax was performed on each dog to evaluate the effects of pneumo thorax on thoracic and on pulmonary cross-sectional area (TA and PA). Arterial PO2 (PaO2) and PCO2 (PaCO2), heart rate (HR), and mean arterial blood pressure (MAP) were determined and related to the severity of pneumothorax. Volumes of air equal to 1, 1.5 and 2 times functional residual capacity of the lung produced approximately 33%, 40%, and 50% reductions in pulmonary area respectively. These amounts of atelectasis correspond to a radiographically “moderate” degree of pneumothorax. As severity of pneumothorax increased, thoracic area consistently increased, PaO2 consistently decreased, and PaCO2 consistently increased, with all being statistically significant relationships (p0.2)

  12. The enhancement effects of xenon gas inhalation for the image analysis of the blood brain barrier damage

    International Nuclear Information System (INIS)

    The enhancement study of the Iodide contained contrast material has been performed since Gado had presented its clinical application at the workshop on Reconstruction Tomography in 1975. In 1977, Winkler et al. reported the clinical utilization of Xenon gas enhancement study. However many literatures treated the partition coefficient and washout study of Xenon gas just like the radioactive Xenon-133. There are very few informations concerning the image analysis of Xenon enhanced CT. The image analysis of the reconstructed sagittal and coronal pictures with Xenon gas inhalation has been performed in this study. The ischemic small lesion of cerebral infarction is not usually identified in ordinary CT view. Three cases who had the T.I.A. of negative CT were clearly demonstrated in the reconstructed pictures with Xenon gas inhalation. And one case of left parietal glioma showed the partial negative image with Xenon gas CT among the slightly enhanced edema lesion. This part might be the infiltrating lesion of tumor. There are very few cases presented here, but the clinical application to detect the small lesion of cerebral parenchymal damage with Xenon gas inhalation might have some value and the image analysis study with the reconstruced sagittal and coronal view may have the role of detailed detection of small lesions. (author)

  13. Blood stain pattern analysis.

    Science.gov (United States)

    Peschel, O; Kunz, S N; Rothschild, M A; Mützel, E

    2011-09-01

    Bloodstain pattern analysis (BPA) refers to the collection, categorization and interpretation of the shape and distribution of bloodstains connected with a crime. These kinds of stains occur in a considerable proportion of homicide cases. They offer extensive information and are an important part of a functional, medically and scientifically based reconstruction of a crime. The following groups of patterns can essentially be distinguished: dripped and splashed blood, projected blood, impact patterns, cast-off stains, expirated and transferred bloodstains. A highly qualified analysis can help to estimate facts concerning the location, quality and intensity of an external force. A sequence of events may be recognized, and detailed questions connected with the reconstruction of the crime might be answered. In some cases, BPA helps to distinguish between accident, homicide and suicide or to identify bloodstains originating from a perpetrator. BPA is based on systematic training, a visit to the crime scene or alternatively good photographic documentation, and an understanding and knowledge of autopsy findings or statements made by the perpetrator and/or victim. A BPA working group has been established within the German Society of Legal Medicine aiming to put the knowledge and practical applications of this subdiscipline of forensic science on a wider basis. PMID:21069481

  14. Continuous blood gas monitoring in femoral arteries

    Science.gov (United States)

    Schlain, Les A.; Spar, Steven M.; Dellinger, Bart

    1995-05-01

    Continuous intra-arterial blood gas monitoring is a potentially valuable tool in the surgical and intensive care arenas. Patient oxygenation and acid base status can change rapidly and without warning. The ability to monitor pHa, PaCO2 and PaO2 in arterial blood will be a major medical advance for the anesthesiologist and intensivist. Intra-arterial blood gas sensors are typically placed in radial arteries. In certain patient populations accurate monitoring is not possible in radial arteries due to arterial environmental factors such as hypotension, vasoconstriction and atherosclerotic disease. These same factors can make radial cannulation difficult resulting in traumatic catheter insertion, thereby further compromising flow conditions. In situations where radial artery flow is expected to be compromised, selecting a large vessel for sensor placement is desirable. We report an initial feasibility study of our blood gas monitoring system using the femoral artery as the sensing site. Clinical results are presented as well as potential advantages and disadvantages associated with monitoring in the femoral artery.

  15. GC-NPD and GC-MS analysis of preserved tissue of Bhopal gas disaster: evidence of methyl carbamylation in post-mortem blood.

    Science.gov (United States)

    Sriramachari, S; Rao, G J; Sharma, V K; Jadhav, R K; Saraf, A K; Chandra, H

    1991-10-01

    Twenty-five preserved autopsy blood samples of Bhopal toxic gas exposed victims were analysed by gas chromatography (GC) coupled with either Nitrogen-Phosphorous detector (NPD) or mass spectrometer (MS) for the presence of methyl carbamyl valine in terms of valine methyl hydantoin (VMH). 84% of these samples showed a positive test for VMH on GC-NPD and the identity of the peaks were further confirmed on GC-MS. The concentration of VMH in the gas-affected positive blood samples ranged from 2.56 to 51.28 nanomoles. These results indicate entry of methyl isocyanate (MIC), one of the constituents of the toxic cloud caused by the disaster, into the blood stream of victims who had inhaled gas. PMID:1795610

  16. Blood gas analysis, anion gap, and strong ion difference in horses treated with polyethylene glycol balanced solution (PEG 3350 or enteral and parenteral electrolyte solutions

    Directory of Open Access Journals (Sweden)

    Cláudio Luís Nina Gomes

    2014-06-01

    Full Text Available Large volumes of different electrolytes solutions are commonly used for ingesta hydration in horses with large colon impaction, but little is known about their consequences to blood acid-base balance. To evaluate the effects of PEG 3350 or enteral and parenteral electrolyte solutions on the blood gas analysis, anion gap and strong ion difference, five adult female horses were used in a 5x5 latin square design. The animals were divided in five groups and distributed to each of the following treatments: NaCl (0.9% sodium chloride solution; EES (enteral electrolyte solution, EES+LR (EES plus lactated Ringer's solution; PEG (balanced solution with PEG 3350 and PEG+LR (PEG plus lactated Ringer's solution. Treatments PEG or PEG + LR did not change or promoted minimal changes, while the EES caused a slight decrease in pH, but its association with lactated Ringer's solution induced increase in AG and SID values, as well as caused hypernatremia. In turn, the treatment NaCl generated metabolic acidosis. PEG 3350 did not alter the acid-base balance. Despite it's slight acidifying effect, the enteral electrolyte solution (EES did not cause clinically relevant changes.

  17. Blood gas analysis features of H7N9 influenza patients%H7N9流感患者15例血气分析

    Institute of Scientific and Technical Information of China (English)

    汤阳; 卢洪洲

    2014-01-01

    Objective To review the blood gas analysis of H7N9 flu patients for better understanding the characteristics and prognosis of the emerging disease.Methods A retrospective review was conducted for the 15 H7N9 influenza patients,whose blood gas profile was tested with a Radiometer 80 Blood Gas Analyzerin our hospital.The profile of blood gas analysis was compared between the 12 surviving patients and the 3 deaths in terms of their outcomes.Results The 3 patients who died of H7N9 influenza averaged 83 years old.The partial pressure of oxygen was <8 kPa in 9 of the 12 surviving patients,which meet the diagnostic criteria of type I respiratory failure.Their partial pressure of oxygen all recovered to normal (11 .033 ± 2.335 kPa,reference range 10-14 kPa)on discharge.The pH value of peripheral arterial bloold averaged 7.335 (range 7.39-7.54)on adission for the 3 patients who died of H7N9 influenza.The worst average pH value was 7.233 (range 7.32-7.35), which was significantly different from the values of the surviving patients.Conclusions Elderly patients are susceptible to H7N9 influenza infection and subsequent respiratory failure.Old age was associated with higher mortality.The partial pressure of ox-ygen is not significantly associated with patient outcomes.Appropriate active treatment may recover the blood gas profile to normal regardless of the initial values.If decreasing peripheral arterial bloold pH value is highly suggestive of poor prognosis, comprehensive measures should be taken to keep acid-base balance,including assisted ventilation to correct hypoxemia.%目的:探讨 H7N9流感患者的血气分析特点,了解新发疾病的特点及转归,以便采取有效治疗。方法采用雷度(Radiometer)ADL80血气分析仪对15例 H7N9流感患者进行血气分析,并比较好转患者与死亡患者的血气分析结果及预后。结果15例患者中,12例治愈出院,3例死亡,死亡患者的平均年龄为83岁,12例好转患者中9

  18. Prediction of arterial blood gas values from arterialized earlobe blood gas values in patients treated with mechanical ventilation

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    Honarmand Azim

    2008-01-01

    Full Text Available Background/Objective: Arterial blood gas (ABG analysis is useful in evaluation of the clinical condition of critically ill patients; however, arterial puncture or insertion of an arterial catheter may sometimes be difficult and cause many complications. Arterialized ear lobe blood samples have been described as adequate to gauge gas exchange in acute and chronically ill pediatric patients. Purpose: This study evaluates whether pH, partial pressure of oxygen (PO 2 , partial pressure of carbon dioxide (PCO 2 , base excess (BE, and bicarbonate (HCO 3 values of arterialized earlobe blood samples could accurately predict their arterial blood gas analogs for adult patients treated by mechanical ventilation in an intensive care unit (ICU. Setting: A prospective descriptive study Methods: Sixty-seven patients who were admitted to ICU and treated with mechanical ventilation were included in this study. Blood samples were drawn simultaneously from the radial artery and arterialized earlobe of each patient. Results: Regression equations and mean percentage-difference equations were derived to predict arterial pH, PCO 2 , PO 2 , BE, and HCO 3 -values from their earlobe analogs. pH, PCO 2 , BE, and HCO 3 all significantly correlated in ABG and earlobe values. In spite of a highly significant correlation, the limits of agreement between the two methods were wide for PO 2 . Regression equations for prediction of pH, PCO 2 , BE, and HCO3- values were: arterial pH (pHa = 1.81+ 0.76 x earlobe pH (pHe [r = 0.791, P < 0.001]; PaCO 2 = 1.224+ 1.058 x earlobePCO 2 (PeCO 2 [r = 0.956, P < 0.001]; arterial BE (BEa = 1.14+ 0.95 x earlobe BE (BEe [r= 0.894, P < 0.001], and arterial HCO 3 - (HCO 3 -a = 1.41+ earlobe HCO 3 (HCO 3 -e [r = 0.874, P < 0.001]. The predicted ABG values from the mean percentage-difference equations were derived as follows: pHa = pHe x 1.001; PaCO 2 = PeCO 2 x 0.33; BEa = BEe x 0.57; and HCO 3 -a = HCO 3 -e x 1.06. Conclusions: Arterialized

  19. Analysis of bias in measurements of potassium, sodium and hemoglobin by an emergency department-based blood gas analyzer relative to hospital laboratory autoanalyzer results.

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    Jian Bo Zhang

    Full Text Available The emergency departments (EDs of Chinese hospitals are gradually being equipped with blood gas machines. These machines, along with the measurement of biochemical markers by the hospital laboratory, facilitate the care of patients with severe conditions who present to the ED. However, discrepancies have been noted between the Arterial Blood Gas (ABG analyzers in the ED and the hospital laboratory autoanalyzer in relation to electrolyte and hemoglobin measurements. The present study was performed to determine whether the ABG and laboratory measurements of potassium, sodium, and hemoglobin levels are equivalent, and whether ABG analyzer results can be used to guide clinical care before the laboratory results become available.Study power analyses revealed that 200 consecutive patients who presented to our ED would allow this prospective single-center cohort study to detect significant differences between ABG- and laboratory-measured potassium, sodium, and hemoglobin levels. Paired arterial and venous blood samples were collected within 30 minutes. Arterial blood samples were measured in the ED by an ABL 90 FLEX blood gas analyzer. The biochemistry and blood cell counts of the venous samples were measured in the hospital laboratory. The potassium, sodium, and hemoglobin concentrations obtained by both methods were compared by using paired Student's t-test, Spearman's correlation, Bland-Altman plots, and Deming regression.The mean ABG and laboratory potassium values were 3.77±0.44 and 4.2±0.55, respectively (P<0.0001. The mean ABG and laboratory sodium values were 137.89±5.44 and 140.93±5.50, respectively (P<0.0001. The mean ABG and laboratory Hemoglobin values were 12.28±2.62 and 12.35±2.60, respectively (P = 0.24.Although there are the statistical difference and acceptable biases between ABG- and laboratory-measured potassium and sodium, the biases do not exceed USCLIA-determined limits. In parallel, there are no statistical differences and

  20. 20 CFR 718.105 - Arterial blood-gas studies.

    Science.gov (United States)

    2010-04-01

    ... DEATH DUE TO PNEUMOCONIOSIS Criteria for the Development of Medical Evidence § 718.105 Arterial blood... test shall be offered to the miner unless medically contraindicated. If an exercise blood-gas test is... Appendix C is administered during a hospitalization which ends in the miner's death, then any such...

  1. Analisis Gas Darah pada Kucing yang Mengalami Laparohisterotomi dengan Anestesi Xylazin-Ketamin dan Xylazin-Propofol (BLOOD GAS ANALYSIS OF XYLAZIN- KETAMIN AND XYLAZIN-PROPOFOL FOR ANESTHESIA TO LAPARO-HISTEROTOMY SURGERY IN CAT

    Directory of Open Access Journals (Sweden)

    Ira Sari Yudaniayanti

    2012-03-01

    Full Text Available The aim of this research was to study the safety application of xylazine-ketamine and xylazinepropofolrecurrent dosage combination as anesthesia for laparo-histerotomy surgery in cat. Thisresearch used 10 female cats, 12-18 months of age, followed randomly divided into two groups, P1:atropine 0,04 mg/kgBW/SC + xylazine 2 mg/kg BW/IM + ketamine 20 mg/kg BW/IM; P2 : atropine0,04mg/kg BW/SC + xylazine 2 mg/kg BW/IM + Propofol 20 mg/kg BW/IV. The blood of the allgroups was taken from vena femuralis at 0 minute (before treatment, 15, 30, 45 and 60 minutesduring anesthesia for measurement of blood gas value pH, pCO2 and HCO3. After all animals wereanesthetized, the animals were treated laparo-histerotomy surgery. The data were analyzed byusing Randomized Complete Block Design (RCBD. The result showed both of groups were notsignificantly difference (p>0,05 to blood gas values for pH, pCO2 dan HCO3. Besides, both groupsanaesthetic agent perfectly caused metabolic acidosis with respiratory alkalosis compensationperfectly, therefore it is relatively safe to use as anaesthetic agent for surgery that needs long timeprocedure, as laparo-histerotomy.

  2. Hanford gas dispersion analysis

    International Nuclear Information System (INIS)

    An analysis was performed to verify the design of a waste gas exhauster for use in support of rotary core sampling activities at the Westinghouse Hanford Waste Tank Farm. The exhauster was designed to remove waste gases from waste storage tanks during the rotary core drilling process of the solid materials in the tank. Some of the waste gases potentially are very hazardous and must be monitored during the exhauster's operation. If the toxic gas concentrations in specific areas near the exhauster exceed minimum Threshold Limit Values (TLVs), personnel must be excluded from the area. The exhauster stack height is of interest because an increase in stack height will alter the gas concentrations at the critical locations. The exhaust stack is currently ∼4.6 m (15 ft) high. An equipment operator will be located within a 6.1 m (20 ft) radius of the exhaust stack, and his/her head will be at an elevation 3.7 m (12 ft) above ground level (AGL). Therefore, the maximum exhaust gas concentrations at this location must be below the TLV for the toxic gases. Also, the gas concentrations must be within the TLV at a 61 m (200 ft) radius from the stack. If the calculated gas concentrations are above the TLV, where the operator is working below the stack at the 61 m (200 ft) radius location, the stack height may need to be increased

  3. Validation protocol for multiple blood gas analyzers in accordance with laboratory accreditation programs

    OpenAIRE

    Pérsio A. R. Ebner; Paschoalina Romano; Alexandre Sant’Anna; Maria Elizabete Mendes; Magna Oliveira; Nairo M. Sumita

    2015-01-01

    ABSTRACTIntroduction:The results of blood gas analysis using different instrumentation can vary widely due to the methodological differences, the calibration procedures and the use of different configurations for each type of instrument.Objective:The objective of this study was to evaluate multiple analytical systems for measurement of blood gases, electrolytes and metabolites in accordance with the accreditation program (PALC) of Sociedade Brasileira de Patologia Clínica/Medicina Laboratoria...

  4. [A gas chromatographic method for determining acetaldehyde in cadaver blood].

    Science.gov (United States)

    Savich, V I; Valladares, Kh A; Gusakov, Iu A; Skachko, Z M

    1990-01-01

    Gas-chromatographic method of acetaldehyde detection in blood of subjects who died of alcoholic intoxication is suggested. Method is simple, does not require additional expenses, can be readily used in medicolegal practice and in difficult cases it may help the expert to make an objective conclusion on the cause of death. PMID:2087747

  5. 21 CFR 870.4410 - Cardiopulmonary bypass in-line blood gas sensor.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Cardiopulmonary bypass in-line blood gas sensor... Cardiopulmonary bypass in-line blood gas sensor. (a) Identification. A cardiopulmonary bypass in-line blood gas sensor is a transducer that measures the level of gases in the blood. (b) Classification. Class...

  6. Analysis of Arterial and Venous Blood Gases in Healthy Gyr Falcons ( Falco rusticolus ) Under Anesthesia.

    Science.gov (United States)

    Raghav, Raj; Middleton, Rachael; BSc, Rinshiya Ahamed; Arjunan, Raji; Caliendo, Valentina

    2015-12-01

    Arterial and venous blood gas analysis is useful in the assessment of tissue oxygenation and ventilation and in diagnosis of metabolic and respiratory derangements. It can be performed with a relatively small volume of blood in avian patients under emergency situations. Arterial and venous blood gas analysis was performed in 30 healthy gyr falcons ( Falco rusticolus ) under anaesthesia to establish temperature-corrected reference intervals for arterial blood gas values and to compare them to temperature-corrected venous blood gas values with a portable point-of-care blood gas analyzer (i-STAT 1, Abbott Laboratories, Abbott Park, IL, USA). Statistically significant differences were observed between the temperature-corrected values of pH, partial pressure of carbon dioxide (Pco2), and partial pressure of oxygen (Po2) and the corresponding nontemperature-corrected values of these parameters in both arterial and venous blood. Values of temperature-corrected pH, temperature-corrected Pco2, bicarbonate concentrations, and base excess of extra cellular fluid did not differ significantly between arterial and venous blood, suggesting that, in anesthetized gyr falcons, venous blood gas analysis can be used in place of arterial blood gas analysis in clinical situations. Values for hematocrit, measured by the point-of-care analyzer, were significantly lower compared with those obtained by the microhematocrit method. PMID:26771318

  7. Direct Determination of the Blood Concentration of Halogenated Anesthetic Agents by Gas Chromatography

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    Yamada,Teruo

    1988-08-01

    Full Text Available The direct determination by gas chromatography of blood levels of anesthetic agents has been difficult because of the water content of blood. In the present study, the method of Yokota et al. (1967 was modified by improving the packing materials of the column, the blood sample vaporizer and the flow-path during analysis. As a result, accurate and reproducible determination of halothane, enflurane and isoflurane dissolved in blood was achieved. With this system, blood in which halothane, enflurane and isoflurane had been dissolved could be analyzed without changing the column between samples. Moreover, each sample was prepared in less than 10 min, and more than 100 consecutive determinations could be made with excellent reproducibility. The coefficient of variation was less than 3.8%.

  8. Significance of serum procalcitonin and blood gas analysis in the risk anticipation of patients with acute exacerbation of COPD%血清降钙素原联合血气分析检测对AECOPD患者临床风险预测的意义

    Institute of Scientific and Technical Information of China (English)

    曹友红

    2013-01-01

    Objective To estimate the prognostic value of serum procalcitonin and blood gas analysis in the risk anticipation of patients with acute exacerbation of chronic obstructive pulmonary disease ( AECOPD ). Methods The study selected 65 patients with AECOPD as the test group and 50 healthy people as the control group. Their PCT level and arterial blood gas analysis indexes were tested and dynamically monitored 5 days after the treatment. Results Serum procalcitonin and blood gas analysis had a high sensitivity, and the differences showed a statistical significance before and after the treatment (P 0.05).结论 联合检测血清降钙素原及血气分析对AECOPD患者的风险预测具有较重要的临床意义.

  9. 脐动脉血血气分析对新生儿窒息的预后评估价值%Gas analysis of umbilical cord artery blood on predicating the prognosis of asphyxia neonate

    Institute of Scientific and Technical Information of China (English)

    曹棨; 潘革; 莫锦丽; 何潇; 农常亮; 黄芬

    2016-01-01

    目的:探讨脐动脉血与桡动脉血血气分析在缺氧新生儿预后评估中的临床应用价值。方法选取2014年9月至2015年9月我院分娩的足月新生儿328例,根据Apgar评分分为重度窒息组11例、轻度窒息组27例、健康对照组290例,出生后取脐动脉血、桡动脉血行血气分析,计算氧合指数,定期随访窒息组新生儿行为神经评估( NBNA)结果,分析其与脐动脉血血气分析pH值之间的关系。结果重度窒息组脐动脉血的pH值、PO2、PCO2、氧合指数分别为7�11±0�25、(73�93±23�35) mmHg、(51�36±16�37) mmHg、206�23±98�12,与轻度窒息组[7�24±0�05、(86�35±12�56) mmHg、(45�89±9�21) mmHg、411�22±57�94]和健康对照组[7�28±0�08、(87�80±12�07) mmHg、(43�68±6�45) mmHg、426�23±73�30]比较,差异均有统计学意义( P均<0�05);桡动脉血 pH 值、PO2、PCO2、氧合指数分别为7�25±0�18、(74�66±24�09) mmHg、(51�42±17�83) mmHg、332�03±65�19,与轻度窒息组[7�31±0�09、(87�24±11�75) mmHg、(45�73±10�21) mmHg、405�67±82�65]和健康对照组[7�32±0�06、(87�99±11�81) mmHg、(42�84±9�32) mmHg、439�89±60�76]比较差异均有统计学意义(P均<0�05);重度窒息组NBNA为(34�09±5�02)分,低于轻度窒息组[(36�62±2�04)分],差异有统计学意义(F=21�65,P<0�05);重度窒息组脐动脉血pH值与NBNA呈正相关( r=0�877,P<0�01)。结论重度窒息组脐动脉血与桡动脉血血气分析的pH值、PO2、氧合指数下降,PCO2升高。重度窒息组NBNA与脐动脉血气分析pH值相关,脐动脉血气分析pH值有助于评估新生儿近期预后。%Objective To study the gas analysis of umbilical cord artery blood and radial artery blood on predicating the prognosis of asphyxia neonate

  10. Oxygen tension measurement using an automatic blood gas analyser.

    Science.gov (United States)

    Becket, J; Orchard, C; Chakrabarti, M K; Hall, G M; Gillies, I D; Bourdillon, P J

    1981-08-01

    Two different methods of assessing the reliability of the oxygen electrode of one model of an automatic blood gas analyser (BGA) have been studied. In the first, a single automatic BGA was assessed by using outdated bank blood which was pumped around a small extracorporeal circuit into which known gas mixtures were passed. Oxygen tension was varied between 2 and 16 kPa. In the second, fresh heparinized blood was tonometered with calibrated gases and submitted to the automatic BGA used in the first part of the study and also to three other identical machines. Each of the machines was between 3 and 4 years old.Eighteen different units of blood were used in the first part of the study. The correlation coefficient between the automatic BGA and the Po(2) in the extracorporeal circuit varied between 0.29 and 0.99. 31% of the total of 209 measurements made by the automatic BGA were more than 1.2 kPa from the reference value, 25% of them being between 1.2 and 4.0 kPa from the reference value. In the second part of the study, the correlation coefficient between this automatic BGA and the tonometered blood was 0.96. The correlation coefficients for the 3 other identical BGAs were 0.84, 0.97 and 0.88, indicating that the BGA used in the first part of the study was no worse than any of the others.It is suggested that although clinicians are likely to ignore readings of an automatic BGA that are more than 4.0 kPa from the true value and are likely to repeat the investigation, readings between 1.2 and 4.0 kPa from the true value may adversely affect patient management. PMID:7288796

  11. Hemograma e hemogasometria de eqüinos submetidos à obstrução experimental de jejuno Hemogram and blood gas analysis of equines submitted to jejuni experimental obstruction

    Directory of Open Access Journals (Sweden)

    N.S. Costa

    2008-12-01

    Full Text Available Foram utilizados oito eqüinos distribuídos em dois grupos, submetidos ou não à obstrução experimental do jejuno mediante a colocação de um balão intraluminal. Os animais do grupo 1 foram submetidos à enterotomia com colocação do balão sem distensão suficiente para provocar isquemia e os do grupo 2 à isquemia por obstrução do jejuno durante quatro horas. Para determinação do hemograma e da hemogasometria foram obtidas amostras de sangue venoso em quatro momentos: uma hora antes do procedimento cirúrgico (M1, ao final da obstrução/isquemia (M2 e uma hora (M3 e 18 horas (M4 após o início da reperfusão/desobstrução. Não houve diferença entre grupos nas contagens de hemácias, leucócitos totais, neutrófilos bastonetes, neutrófilos segmentados, linfócitos e monócitos, bem como no teor de hemoglobina. Houve diferença no volume globular em M2 e na contagem de eosinófilos em M3. Na hemogasometria, em ambos os grupos, registrou-se diminuição dos teores de sódio, potássio, cálcio ionizado e cloro, da pressão parcial de oxigênio e da saturação de oxiemoglobina. Os resultados indicam que o hemograma, isoladamente, não fornece informações conclusivas, enquanto a hemogasometria possibilita determinar, precocemente, o volume de reposição hidroeletrolítica a ser administrado em eqüino com abdômen agudo decorrente de obstrução de jejuno, auxiliando no tratamento e no melhor prognóstico da afecção intestinal.Eight equines were distributed into two different groups. Those groups were submitted or not to an experimental jejunal obstruction. Animals from group 1 were submitted to an enterotomy with placement of an intraluminal balloon, without enough distention to cause ischemia; animals from group 2 were submitted to ischemia by jejunal obstruction during four hours. In order to determine the hemogram and blood gas analysis, blood samples from peripheral vein were obtained at four moments: one hour before the

  12. Effects of xuebijing parenteral solution on blood coagulation function and blood gas analysis in severe sepsis patients%血必净注射液对严重脓毒症患者凝血功能及血气分析的影响

    Institute of Scientific and Technical Information of China (English)

    张连东; 裴新军

    2012-01-01

    目的 探讨血必净注射液对严重脓毒症患者凝血功能及血气分析的影响.方法 用前瞻性研究方法,选择2010-01~2012-07我院急诊重症监护病房(ICU)收治的严重脓毒症患者120例,随机分为对照组和治疗组.对照组予以抗感染、激素、维持水、电解质及酸碱平衡等常规治疗;治疗组在常规治疗的基础上加用血必净注射液100 mL溶于5%的葡萄糖注射液250 mL中静脉滴注,2次/d,共7 d.分别于治疗前及治疗7 d后测定凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、凝血酶时间(TT)、血小板计数(PLT)及血气分析.比较对照组和治疗组治疗前后PT、APTT、FIB、TT、PLT及血气分析变化.结果 与治疗前比较,治疗后两组PT、APTT、TT延长,FIB升高,PLT和氧合均改善(均P0.05).结论 血必净注射液能改善严重脓毒症患者高凝状态和氧合,为临床治疗严重脓毒症提供了新参考.%Objective To invesligale the effects of xuebijing parenleral solution on blood coagulalion funclion and blood gas analysis in severe sepsis palienls. Methods 120 palienls of severe sepsis were randomly divided into Lwo groups; conlrol group ( 60 cases) and trealmenl group ( 60 cases) . The basic trealmenls of Lwo groups included primary disease trealmenl. , anti - infection,adrenal cortical hormone trealmenl and keeping the balance of water - eleclrolyle. The trealmenl group was supernumerarily injecled with xuebijing parenleral solulion 100 mL and 5% glucose solulion injection 250 mL for 7 d, bid. Prolhrombin lime(PT) , aclivaled partial thromboplaslin lime ( APTT) , fibrin (Fib) , ihromboplaslin lime(TT) , parameter of blood plalelels and blood gas analysis were measured before the trealmenl and 7days after the trealmenl. PT, APTT, Fib, TT, parameter of blood plalelels and blood gas analysis of lwo groups were compared before and afler the trealmenl. Results Compared with conlrol group, PT, APTT and TT

  13. Prediction of blood:air and fat:air partition coefficients of volatile organic compounds for the interpretation of data in breath gas analysis.

    Science.gov (United States)

    Kramer, Christian; Mochalski, Paweł; Unterkofler, Karl; Agapiou, Agapios; Ruzsanyi, Veronika; Liedl, Klaus R

    2016-03-01

    In this article, a database of blood:air and fat:air partition coefficients (λ b:a and λ f:a) is reported for estimating 1678 volatile organic compounds recently reported to appear in the volatilome of the healthy human. For this purpose, a quantitative structure-property relationship (QSPR) approach was applied and a novel method for Henry's law constants prediction developed. A random forest model based on Molecular Operating Environment 2D (MOE2D) descriptors based on 2619 literature-reported Henry's constant values was built. The calculated Henry's law constants correlate very well (R(2) test  =  0.967) with the available experimental data. Blood:air and fat:air partition coefficients were calculated according to the method proposed by Poulin and Krishnan using the estimated Henry's constant values. The obtained values correlate reasonably well with the experimentally determined ones for a test set of 90 VOCs (R(2)  =  0.95). The provided data aim to fill in the literature data gap and further assist the interpretation of results in studies of the human volatilome. PMID:26815030

  14. Multi-element analysis of blood plasma

    International Nuclear Information System (INIS)

    Two examples of multi-element analysis (MA) - semiconductor gamma spectrometry of natural and artificial radionuclides, and neutron activation analysis - of eight samples of lyophilized pooled plasma (a total of 124 subjects) from four localities of the regions Central Bohemia and Prague, show the scope for its use, e.g., in transfusion services. This consists in the use of ecological screening made up of five stages: preliminary rating of the intensity of ecological interactions in an individual or a group of blood donors; sample taking with the date and hour of sampling; determination of ecological interaction intensity tracers for an individual or for groups of blood donors using the appropriate MA method; comparisons of pre-rated and MA-established intensity of ecological interactions of an individual or a group of blood donors; standardization of MA results according to the date and hour of sampling. (author)

  15. Implementation of the ABL-90 blood gas analyzer in a ground-based mobile emergency care unit

    DEFF Research Database (Denmark)

    Mikkelsen, Søren; Wolsing-Hansen, Jonathan; Nybo, Mads;

    2015-01-01

    Point-of Care analysis is increasingly being applied in the prehospital scene. Arterial blood gas analysis is one of many new initiatives adding to the diagnostic tools of the prehospital physician. In this paper we present a study on the feasibility of the Radiometer ABL-90 in a ground...

  16. Validation protocol for multiple blood gas analyzers in accordance with laboratory accreditation programs

    Directory of Open Access Journals (Sweden)

    Pérsio A. R. Ebner

    2015-10-01

    Full Text Available ABSTRACTIntroduction:The results of blood gas analysis using different instrumentation can vary widely due to the methodological differences, the calibration procedures and the use of different configurations for each type of instrument.Objective:The objective of this study was to evaluate multiple analytical systems for measurement of blood gases, electrolytes and metabolites in accordance with the accreditation program (PALC of Sociedade Brasileira de Patologia Clínica/Medicina Laboratorial (SBPC/ML.Materials and methods:20 samples were evaluated in three ABL800 Flex (Radiometer Medical ApS, Denmark blood gas analyzers, and the results were compared with those of the device in use, which was considered the reference. The analysis of variance (Anova was applied for statistical purposes, as well as the calculation of mean, standard deviation and coefficient of variation.Results:The p values obtained in the statistical analysis were: pH = 0.983, pO2 = 0.991, pCO2 = 0.353, lactate = 0.584, glucose = 0.995, ionized calcium = 0.983, sodium = 0.991, potassium = 0.926, chlorine = 0.029.Conclusion:The evaluation of multiple analytical systems is an essential procedure in the clinical laboratory for quality assurance and accuracy of the results.

  17. Analisis Gas Darah pada Kucing yang Mengalami Laparohisterotomi dengan Anestesi Xylazin-Ketamin dan Xylazin-Propofol (BLOOD GAS ANALYSIS OF XYLAZIN- KETAMIN AND XYLAZIN-PROPOFOL FOR ANESTHESIA TO LAPARO-HISTEROTOMY SURGERY IN CAT)

    OpenAIRE

    Ira Sari Yudaniayanti; Nusdianto Triakoso; Djoko Galijono

    2012-01-01

    The aim of this research was to study the safety application of xylazine-ketamine and xylazinepropofolrecurrent dosage combination as anesthesia for laparo-histerotomy surgery in cat. Thisresearch used 10 female cats, 12-18 months of age, followed randomly divided into two groups, P1:atropine 0,04 mg/kgBW/SC + xylazine 2 mg/kg BW/IM + ketamine 20 mg/kg BW/IM; P2 : atropine0,04mg/kg BW/SC + xylazine 2 mg/kg BW/IM + Propofol 20 mg/kg BW/IV. The blood of the allgroups was taken from vena femural...

  18. Continuous arterial blood gas monitoring in rabbits: an efficient method for evaluation of ratio-based optrodes

    Science.gov (United States)

    Martin, Roy C.; Olstein, Alan D.; Malin, Stephen F.; Perkovich, Anne

    1992-04-01

    Laboratory bench testing of optical blood gas sensors is insufficient to completely predict capabilities. Sensor testing in animals offers advantages of known physiologic and regulatory mechanisms of hemodynamics to better predict sensor performance. The domestic rabbit, Oryctalogis Cuniculus, a lagomorph of the family Leporidae was used for sensor evaluation. The rabbits are ventilated and blood gases modulated by variations in FIO2 and rate adjustments. Twenty gauge catheters are placed in the dorsal aorta, cartoid, and femoral arteries. Pressures are monitored via transducers on the arterial lines. The optical blood gas sensors are fitted within the catheters and blood samples are collected over them for bench analysis. Sensors are on 125 micrometers glass optic fibers. Proprietary prepolymers are applied on the fiber tips through in fiber photopolymerization. These sensors are then calibrated in tonometered water and blood. Sensor monitoring is accomplished through OSR microfluorimetry systems. We have used this model in 26 studies over the past six months evaluating over fifty blood gas sensors. These studies have lasted from six to twenty-four hours. Our correlation of sensor readings to assayed blood samples is r2 equals .97 for pH values of 6.80 - 7.70, r2 equals .94 for PCO2 values of 10 - 175 mmHg and r2 equals .94 for PO2 values of 10 - 350 mmHg.

  19. The usefulness of the arterial blood gas in pure carbon monoxide poisoning.

    Science.gov (United States)

    Lebby, T I; Zalenski, R; Hryhorczuk, D O; Leikin, J B

    1989-04-01

    In a retrospective study of 49 cases of carbon monoxide (CO) intoxication presented to the University of Illinois Hospital (UIH) Emergency Department between November 1986 and April 1988, we looked for a correlation between carboxyhemoglobin (COHb) as determined by a venous sample and the pH as determined by arterial blood gas analysis. The range of COHb levels in our study was 10-64% (mean 21.8% +/- 10.2%). Smoke inhalation cases (n = 3) were excluded from our study because they did not represent pure CO intoxication. Of the remaining 46 cases, 18 had arterial blood gases drawn. In none of these 18 cases (mean COHb 24.5% +/- 12.6%) did we find a correlation between COHb levels and the pH as determined by linear regression analysis. Also, in none of the 18 cases were there any therapeutic interventions associated with the arterial blood gas result. Additionally, in none of the remaining 28 cases were any therapeutic interventions performed with regards to patients' acidosis or ventilatory status (except 100% oxygen administration. We also retrospectively reviewed records of 104 cases who presented to Cook County Hospital Emergency Department with COHb levels over 10% during the period between March 1986 and May 1988. In these cases, we found no significant correlation between COHb level and arterial pH. We therefore conclude that arterial blood gases drawn in order to determine the degree of acidosis in mild CO intoxication without respiratory distress may not be useful in guiding therapeutic intervention and need not be routinely drawn. PMID:2929122

  20. Assessment of a continuous blood gas monitoring system in animals during circulatory stress

    Directory of Open Access Journals (Sweden)

    Renzulli Attilio

    2011-01-01

    Full Text Available Abstract Background The study was aimed to determine the measurement accuracy of The CDI™ blood parameter monitoring system 500 (Terumo Cardiovascular Systems Corporation, Ann Arbor MI in the real-time continuous measurement of arterial blood gases under different cardiocirculatory stress conditions Methods Inotropic stimulation (Dobutamine 2.5 and 5 μg/kg/min, vasoconstriction (Arginine-vasopressin 4, 8 and 16 IU/h, hemorrhage (-10%, -20%, -35%, and -50% of the theoretical volemia, and volume resuscitation were induced in ten swine (57.4 ± 10.7 Kg.Intermittent blood gas assessments were carried out using a routine gas analyzer at any experimental phase and compared with values obtained at the same time settings during continuous monitoring with CDI™ 500 system. The Bland-Altman analysis was employed. Results Bias and precision for pO2 were - 0.06 kPa and 0.22 kPa, respectively (r2 = 0.96; pCO2 - 0.02 kPa and 0.15 kPa, respectively; pH -0.001 and 0.01 units, respectively ( r2 = 0.96. The analysis showed very good agreement for SO2 (bias 0.04,precision 0.33, r2 = 0.95, Base excess (bias 0.04,precision 0.28, r2 = 0.98, HCO3 (bias 0.05,precision 0.62, r2 = 0.92,hemoglobin (bias 0.02,precision 0.23, r2 = 0.96 and K+ (bias 0.02, precision 0.27, r2 = 0.93. The sensor was reliable throughout the experiment during hemodynamic variations. Conclusions Continuous blood gas analysis with the CDI™ 500 system was reliable and it might represent a new useful tool to accurately and timely monitor gas exchange in critically ill patients. Nonetheless, our findings need to be confirmed by larger studies to prove its reliability in the clinical setting.

  1. The physiological basis of pulmonary gas exchange: implications for clinical interpretation of arterial blood gases.

    Science.gov (United States)

    Wagner, Peter D

    2015-01-01

    The field of pulmonary gas exchange is mature, with the basic principles developed more than 60 years ago. Arterial blood gas measurements (tensions and concentrations of O₂ and CO₂) constitute a mainstay of clinical care to assess the degree of pulmonary gas exchange abnormality. However, the factors that dictate arterial blood gas values are often multifactorial and complex, with six different causes of hypoxaemia (inspiratory hypoxia, hypoventilation, ventilation/perfusion inequality, diffusion limitation, shunting and reduced mixed venous oxygenation) contributing variably to the arterial O₂ and CO₂ tension in any given patient. Blood gas values are then usually further affected by the body's abilities to compensate for gas exchange disturbances by three tactics (greater O₂ extraction, increasing ventilation and increasing cardiac output). This article explains the basic principles of gas exchange in health, mechanisms of altered gas exchange in disease, how the body compensates for abnormal gas exchange, and based on these principles, the tools available to interpret blood gas data and, quantitatively, to best understand the physiological state of each patient. This understanding is important because therapeutic intervention to improve abnormal gas exchange in any given patient needs to be based on the particular physiological mechanisms affecting gas exchange in that patient. PMID:25323225

  2. Analysis of Cyanide in Blood by Headspace-Isotope-Dilution-GC-MS

    DEFF Research Database (Denmark)

    Løbger, Lise Lotte; Petersen, Henning Willads; Andersen, Jens Enevold Thaulov

    2008-01-01

    An uncomplicated, rapid, automated procedure for the analysis of low cyanide concentrations in whole blood is reported. The analysis was performed by headspace gas chromatography and mass spectrometry in the (1H12C14N) and m/z 29 (1H13C15N). Carryover from cyanide adsorption onto the surface of t...

  3. Is liquid heparin comparable to dry balanced heparin for blood gas sampling in intensive care unit?

    Directory of Open Access Journals (Sweden)

    Viswas Chhapola

    2014-01-01

    Full Text Available Introduction: Blood gas (BG analysis is required for management of critically ill patients in emergency and intensive care units. BG parameters can be affected by the type of heparin formulations used-liquid heparin (LH or dry balanced heparin (DBH. This study was conducted to determine whether blood gas, electrolyte, and metabolite estimations performed by using DBH and LH are comparable. Materials and Methods: A prospective study was conducted at pediatric intensive care unit (PICU of a tertiary care hospital. Paired venous samples were collected from 35 consecutive children in commercially prepared DBH syringes and custom-prepared LH syringes. Samples were immediately analyzed by blood gas analyzer and compared for pH, pCO 2 , pO 2 , HCO 3 - , Na + , K + , Cl - , and lactate. Paired comparisons were done and agreement was assessed by Bland-Altman difference plots. The 95% limits of absolute agreement (LOA were compared with the specifications for total allowable error (TEa. Results: The P values were significant for all measured parameters, with the exception of pCO 2 and K +. Bland-Altman difference plots showed wide LOA for pCO 2 , pO 2 , HCO3 - , Na + , K + , and Cl - when compared against TEa. For pCO 2 , HCO3 - , Na + , K + , and Cl - , 40%, 23%, 77%, 34%, and 54% of samples were outside the TEa limits, respectively, with LH. Conclusion: Our study showed that there is poor agreement between LH and DBH for the BG parameters pCO2, pO2, HCO3 - , K + , Na + , and Cl - and, thus, are not comparable. But for pH and lactate, LH and DBH can be used interchangeably.

  4. Life-cycle analysis of shale gas and natural gas.

    Energy Technology Data Exchange (ETDEWEB)

    Clark, C.E.; Han, J.; Burnham, A.; Dunn, J.B.; Wang, M. (Energy Systems); ( EVS)

    2012-01-27

    The technologies and practices that have enabled the recent boom in shale gas production have also brought attention to the environmental impacts of its use. Using the current state of knowledge of the recovery, processing, and distribution of shale gas and conventional natural gas, we have estimated up-to-date, life-cycle greenhouse gas emissions. In addition, we have developed distribution functions for key parameters in each pathway to examine uncertainty and identify data gaps - such as methane emissions from shale gas well completions and conventional natural gas liquid unloadings - that need to be addressed further. Our base case results show that shale gas life-cycle emissions are 6% lower than those of conventional natural gas. However, the range in values for shale and conventional gas overlap, so there is a statistical uncertainty regarding whether shale gas emissions are indeed lower than conventional gas emissions. This life-cycle analysis provides insight into the critical stages in the natural gas industry where emissions occur and where opportunities exist to reduce the greenhouse gas footprint of natural gas.

  5. Use of a blood glucose meter for radiochromic film analysis in blood irradiation

    International Nuclear Information System (INIS)

    The use of a diabetic blood glucose meter for radiochromic film dosimetry in blood irradiation using x-ray beams on a medical linear accelerator has been investigated. The glucose meter provides optical density analysis in the visible and infrared region using a reflectance measurement technique. By comparing the 'blood sugar' level output with standard calibration gafchromic films a calibration curve is produced for quantitative analysis. Results show that a reproducible dose to meter output curve can be fitted using a second order polynomial function and that blood irradiation doses in vitro were measured to within 7.9% mean error (as compared to ionization chamber results) using the blood glucose meter. This level of accuracy falls below that measured with a standard densitometer (4.3%); however, results show that the blood glucose meter, which would be available in any haematology department, produces an adequate measure of gafchromic film optical density for blood irradiation dosimetry. (author)

  6. ANALYSIS OF DISCARD OF WHOLE BLOOD AND BLOOD COMPONENTS IN GOVERNMENT HOSPITAL BLOOD BANK IN CENTRAL INDIA

    OpenAIRE

    Vedita Bobde; Sanjay Parate; Dinkar Kumbhalkar

    2015-01-01

    BACKGROUND: Transfusion requests are always more than the supply due to advances in health care delivery . Injudicious use of whole blood and blood components strains the transfusion services. This mandates the proper analysis of real need of transfusion and the discard of this scarce resource. MATERIALS & METHODS: Total 31143 voluntary and...

  7. Neonatal apgar scores and umbilical blood gas changes in vaginal delivery and cesarean: a comparative study

    Directory of Open Access Journals (Sweden)

    SH. Raafati

    2006-07-01

    Full Text Available Background: Umbilical cord blood gas analysis is a useful method for assessment of oxygenation and acid-base status in neonates. Severe fetal acidemia is associated with increased perinatal mortality and increased risk of subsequent impaired neurological development. Due to high percentage of C/S in our country and the effect of anesthetic medications on umbilical blood gases which can cause neonatal acidosis and hypoxemia, the study of umbilical cord blood gas in vaginal delivery versus cesarean section is mandatory. Methods: In this cross-sectional study one hundred samples were taken from Mostafa Khomeini hospital in summer 2004. The samples were taken immediately of umbilical vein after clamping the umbilical cord and analyzed after 10 minutes. Cases were classified in to 3 groups: vaginal delivery (n=40, elective C/S under general anesthesia (n=35 and C/S under spinal anesthesia (n=25. Duration of anesthesia and its effect on blood gas and infants apgar were assessed. Results: In the first group (vaginal delivery mean blood gase parameters were; pH=7.3064.73, pO2=25.246.87, HCO3=20.562.03, Apgar=8.820.38 and pCO2=41.826.57. In the second group (general anesthesia mean blood gaze parameters were: pH=7.3044.73, pO2=38.7014.02, pCO2=43.265.87, HCO3=21.1113 and apgar score=8.170.7. In the third group (spinal anesthesia mean blood gaze parameters were: pH=7.3014.50, pCO2=44.14.99, HCO3=21.382.15, pO2=26.625.5 and apgar=8.600.62. The apgar scores and pO2 demonstrated significant relationship with type of anesthesia. The apgar score was lower and pO2 was higher in C/S under general anesthesia compared with the other two groups. There was significant relationship between duration of anesthesia and umbilical pO With increasing duration of anesthesia, pO2 was reduced. Between the type of delivery and anesthesia duration with PH, pO2, pCO2 and HCO3 were not meaningful relationship (P<0.05. Conclusion: There

  8. Thermodilution versus inert gas rebreathing for estimation of effective pulmonary blood flow

    DEFF Research Database (Denmark)

    Christensen, P; Clemensen, P; Andersen, P K; Henneberg, S W

    2000-01-01

    To compare measurements of the effective pulmonary blood flow (Qep, i.e., nonshunted fraction of cardiac output, Qt) by the inert gas rebreathing (RB) method and the thermodilution (TD) technique in critically ill patients.......To compare measurements of the effective pulmonary blood flow (Qep, i.e., nonshunted fraction of cardiac output, Qt) by the inert gas rebreathing (RB) method and the thermodilution (TD) technique in critically ill patients....

  9. Arterial blood gas levels in high altitude Kashmiri population, India

    Directory of Open Access Journals (Sweden)

    Sheikh Imran Sayeed

    2015-11-01

    Conclusions: The present study might provide useful base line normal values of Arterial Blood Gases for the local population and will be beneficial to the clinicians. [Int J Res Med Sci 2015; 3(11.000: 3283-3287

  10. Corporeal blood gas changes according to duration of drug-induced prolonged erection.

    OpenAIRE

    Kim, S.C.; Seo, K. K.; Oh, C. H.

    1993-01-01

    The corporeal blood gas changes in accordance with the duration of the prolonged erection which developed after intracorporeal pharmacotherapy with papaverine and phentolamine were investigated in 62 impotence patients. The picture of the corporeal blood taken from 15 psychogenic impotence patients (a control group) at 10 minutes after intracavernous injection when they showed full erections was arterial but there was pCO2 rise and pH drop compared to femoral artery blood taken simultaneously...

  11. TEMPO DE VIABILIDADE DE AMOSTRAS DE SANGUE VENOSO BOVINO DESTINADAS AO EXAME HEMOGASOMÉTRICO, QUANDO MANTIDAS SOB CONSERVAÇÃO EM ÁGUA GELADA VIABILITY TIME OF BLOOD GAS ANALYSIS IN BOVINE VENOUS BLOOD SAMPLES STORED IN ICE WATER BATH

    Directory of Open Access Journals (Sweden)

    Júlio Augusto Naylor Lisbôa

    2001-04-01

    adequadamente conservadas em banho de água gelada, mantendo, assim, o seu valor diagnóstico.In order to verify the viability of blood gas analysis in bovine venous blood stored on ice water bath, two samples (10ml each were taken from the jugular vein of 14 healthy animals (7 males and 7 females, 1- to 5-year-old, using plastic syringes and attached needles filled with sodium heparin (1,000IU. The blood samples were obtained anaerobically, the air bubbles observed were immediately removed, and the needle was maintened capped with a rubber stopper. Each syringe of the pair was distinctally stored at room temperature (23-30ºC or in ice water bath (0-4ºC during the experimental period. Values of pH, carbon dioxide (PvCO2 and oxigen (PvO2 tensions, bicarbonate (HCO3-, total carbon dioxide (TCO2, base excess (BE, standard bicarbonate (StB, oxigen saturation (SatO2, and oxigen content (O2 were determined soon after sampling and after 1, 2, 3, 4, 5, 6, 8, 10, 12 and 24 hours. According to the type of storage temperature, the results were analysed through repeated measurements ANOVA, considering the contrast between the mean value of each time and the initial one. On the storage at room temperature, the in vitro changes were characterized from continuous decreases in pH, PvO2, BE, StB, SatO2, and O2 values, and gradual increase in PvCO2, starting at 2- or 3-hour after the collection. In the samples stored at 0-4ºC, on the other hand, the changes in pH occurred only at the 4th hour, and the stability of the PvCO2, BE, and StB values were maintened for up to the 6th hour. These results indicated that the diagnostic utility of blood gas analysis is conserved in bovine venous blood samples adequately stored up to 6 hours in ice water bath, at 0-4ºC.

  12. Blood gas analyzer utility in evaluating oxygen kinetics of the aqueous humor

    Directory of Open Access Journals (Sweden)

    Ismail Ersan

    2015-04-01

    Full Text Available Purpose: To measure the partial pressure of oxygen (PO2 and carbon dioxide (PCO2 and the pH of aqueous humor (AH and arterial blood samples from rabbits using a blood gas analyzer. Methods: Twenty New Zealand rabbits were anesthetized intramuscularly with ketamine and xylazine and were then allowed to breathe room air. Using a gas blood analyzer, arterial blood and AH samples were analyzed for PO2, PCO2, and pH. Results: The mean arterial blood pressure was 87.14 ± 15.0 mmHg. The mean blood and AH PO2 were 95.18 ± 11.76 mmHg and 88.83 ± 9.92 mmHg, the mean blood and AH PCO2 were 25.86 ± 5.46 mmHg and 29.50 ± 5.36 mmHg, and the mean blood and AH pH were 7.38 ± 0.06 and 7.33 ± 0.09, respectively. Conclusion: Conclusions: The blood gas analyzer was easily employed to evaluate the aqueous humor in rabbits. When comparing the results of studies evaluating aqueous PO2, care should be taken to determine the methods used in these studies.

  13. Blood compatibility of gas plasma-treated diamond-like carbon surface-Effect of physicochemical properties of DLC surface on blood compatibility

    International Nuclear Information System (INIS)

    From the knowledge that zwitterion-type polymers show good blood compatibility, the introduction of both cationic and anionic functional groups onto diamond-like carbon (DLC) surface is expected to improve blood compatibility. Thus, DLC films were treated with oxygen and ammonia gas plasmas. The surfaces were characterized in terms of chemical composition by XPS, contact angle, and zeta potential. XPS analysis showed the introductions of a carboxyl group by oxygen plasma treatment and nitrogen atoms by ammonia plasma treatment. The evaluation of blood compatibility for the DLC surfaces was carried out in terms of platelets and the coagulation system. Excellent improvement of platelet compatibility was observed by the treatment with the gas plasmas, regardless of the plasma species. As for the compatibility with the coagulation system, DLC surfaces with a high concentration of carboxyl groups (COOH) markedly activated the system via the intrinsic pathway. However, the surfaces treated with ammonia plasma did not activate the system even though they had high COOH concentration. Measurement of the zeta potential revealed that the ammonia plasma treatment raised the potential from a negative value to a positive one. Though the introduction of amino groups to the surface was not detected directly, the treatment of ammonia plasma changed the electrical state of the DLC surface having COOH group, causing a difference in blood compatibility among the DLCs obtained by various plasma conditions.

  14. Influence of different storage times and temperatures on blood gas and acid-base balance in ovine venous blood

    Directory of Open Access Journals (Sweden)

    H.A. Hussein

    2013-01-01

    Full Text Available The present study was designed to investigate the effects of storage temperature and time on blood gas and acid-base balance of ovine venous blood. Ten clinically healthy sheep were used in this study. A total number of 30 blood samples, were divided into three different groups, and were stored in a refrigerator adjusted to +4 ºC (Group I, n = 10, at RT of about 22-25 ºC (Group II, n = 10 and in an incubator adjusted to 37 ºC (Group III, n = 10 for up to 48 h. Blood samples were analysed for blood gas and acid-base indices at 0, 1, 2, 3, 4, 5, 6, 12, 24 and 48 h of storage. In comparison to the baseline value (0, there were significant decreases of blood pH of samples stored at RT and in the incubator after 1 h (p<0.05, the pH value of refrigerated blood samples exhibited insignificant changes during the study (p<0.05. Mean values of pCO2 showed a significant increase in Group I and Group III after 1 h then a progressive decrease after 12 h in all Groups. Mean pO2 values were significantly higher for Group I after 2 h and for Groups II and III after 1 h (p<0.05. In general, base excess decreased significantly for all the groups during the study especially in Groups II and III. In comparison with baseline values, in all groups, bicarbonate (HCO3 increased between 1 h and 6 h (p<0.05, and later decreased at the end of the study (p<0.05. In conclusion, status of acid-base indices of the samples stored at refrigerator and RT were found within normal reference range and it may be of clinical diagnostic use for up to 6 h.

  15. Automated red blood cell analysis compared with routine red blood cell morphology by smear review

    OpenAIRE

    Dr.Poonam Radadiya; Dr.Nandita Mehta; Dr.Hansa Goswami; Dr.R.N.Gonsai

    2015-01-01

    The RBC histogram is an integral part of automated haematology analysis and is now routinely available on all automated cell counters. This histogram and other associated complete blood count (CBC) parameters have been found abnormal in various haematological conditions and may provide major clues in the diagnosis and management of significant red cell disorders. Performing manual blood smears is important to ensure the quality of blood count results an...

  16. [Hemodynamic analysis of a centrifugal blood pump].

    Science.gov (United States)

    Wang, Yang; Yang, Ming; Xu, Zihao; Zhuang, Xiaoqi; Li, Qilei; Xu, Liang

    2015-01-01

    This paper built the mathematical model of a centrifugal blood pump, which was designed by ourselves, combined it with that of the human cardiovascular system and simulated the coupling system using Matlab. Then we set up the experiment platform, linked the blood pump to mock human cardiovascular system in case of three-stage heart failure, and measured aortic pressure and flow under different speed. The comparison between experiment results and simulation results not only indicates the coupling model is correct and the blood pump works well, but also shows that with the increase of blood pump speed, the pulsation of aortic pressure and flow will be reduced, this situation will affect the structure and function of blood vessels. PMID:26027287

  17. Blood gas and blood biochemical parameter change on the correlation analysis of early diagnosis of pulmonary edema%血气及血生化参数改变对肺水肿早期诊断的相关分析

    Institute of Scientific and Technical Information of China (English)

    郭大敏; 劳程强; 曾灶英

    2015-01-01

    目的:探讨血气以及血生化参数的改变对肺水肿早期诊断的相关意义,为肺水肿的及时确诊和治疗提供一定的理论依据。方法从2013年2月~2014年7月我院收治的肺水肿患者中选取34例作为观察组,同期选择34例健康志愿者作为对照组,分别检测观察组以及对照组的血常规、血气以及血生化指标,并对两个实验组的各项指标进行比较分析。结果观察组的白细胞计数(WBC)明显高于对照组,差异具有统计学意义(P<0.05)。通过对比两个实验组的血气指标结果发现,观察组的pH值、PaO2、PaCO2、SaO2、以及FiO2/PaO2均显著低于对照组,差异具有统计学意义(P<0.05)。而观察组和对照组的血生化指标情况除在K+上存在较为明显差异之外,其余Na+、Cl-、BUN(尿素氮)以及GLU(血糖)差异均无统计学意义(P>0.05)。结论肺水肿患者在早期出现白细胞计数明显增加以及低氧血症持续性进行性加重,加强血常规及血气指标的检测,有利于肺水肿的早期诊断和治疗。%ObjectiveTo investigate the blood gas and blood biochemical parameters related to the change of early diagnosis of pulmonary edema, provides certain theory basis for timely diagnosis and treatment of pulmonary edema.MethodsPulmonary edema patients were randomly selected in our hospital from February 2013 to July 2014, 34 cases as the observation group, select the same period 34 cases of healthy volunteers as control group, the observation group and the control group were detected in the blood routine test, blood gas and blood biochemical index, and the indicators of the two experimental groups were compared and analyzed.Results The white blood cell count (WBC) in the observation group were significantly higher than the control group, the difference was statistically significant (P0.05).Conclusion Patients with pulmonary edema appeared white blood cell count

  18. Penile rehabilitation with a vacuum erectile device in an animal model is related to an antihypoxic mechanism: blood gas evidence.

    Science.gov (United States)

    Lin, Hao-Cheng; Yang, Wen-Li; Zhang, Jun-Lan; Dai, Yu-Tian; Wang, Run

    2013-05-01

    Our previous study showed that vacuum erectile device (VED) therapy has improved erectile function in rats with bilateral cavernous nerve crush (BCNC) injuries. This study was designed to explore the mechanism of VED in penile rehabilitation by analyzing cavernous oxygen saturation (SO2) and to examine the effect of VED therapy on preventing penile shrinkage after BCNC. Thirty adult Sprague-Dawley rats were randomly assigned into three groups: group 1, sham surgery; group 2, BCNC; and group 3, BCNC+VED. Penile length and diameter were measured on a weekly basis. After 4 weeks of therapy, the penile blood was extracted by three methods for blood gas analysis (BGA): method 1, cavernous blood was aspirated at the flaccid state; method 2, cavernous blood was aspirated at the traction state; and method 3, cavernous blood was aspirated immediately after applying VED. SO2 values were tested by the blood gas analyzer. The results showed that VED therapy is effective in preventing penile shrinkage induced by BCNC (Penile shortening: BCNC group 1.9±1.1 mm; VED group 0.3±1.0 mm; PVED group 0.04±0.14 mm; PVED application (88.25%±4.94%) compared to the flaccid (76.53%±4.16%) or traction groups (78.93%±2.56%) (PVED application were 62% arterial and 38% venous blood. These findings suggest that VED therapy can effectively preserve penile size in rats with BCNC injury. The beneficial effect of VED therapy is related to antihypoxia by increasing cavernous blood SO2. PMID:23564044

  19. Genetic and phenotypic relationships between blood gas parameters and ascites-related traits in broilers.

    Science.gov (United States)

    Closter, A M; van As, P; Groenen, M A M; Vereijken, A L J; van Arendonk, J A M; Bovenhuis, H

    2009-03-01

    Ascites, also called pulmonary hypertension syndrome, is a metabolic disorder in chickens that have an insufficient pulmonary vascular capacity. The tendency of broilers to develop ascites is heritable, and successful selection against this susceptibility would benefit from good and easy-to-measure indicator traits. Blood gas parameters have been suggested as indicator traits for ascites susceptibility. Therefore, the aim of the present study was to estimate the heritability of blood gas parameters and the genetic and phenotypic correlations between blood gas parameters, heart ratio (postmortem indicator for ascites), and BW at 2 different ages. For this purpose, blood gas parameters, including the partial pressure of carbon dioxide in venous blood (pvCO(2)), the partial pressure of oxygen in venous blood (pvO(2)), and blood oxygen saturation, were measured at an average age of 22 d in nearly 3,000 broilers. To challenge the resistance of the birds to ascites, they were kept under cold conditions. Heritability for heart ratio was 0.43, and the heritability estimates were low: 0.02 for pvCO(2), 0.03 for pvO(2), and 0.07 for blood oxygen saturation. The estimated heritability for pH was 0.15, for bicarbonate was 0.19, and for total carbon dioxide content was 0.19. The genetic correlations between heart ratio and total carbon dioxide content (0.31 +/- 0.15) and between heart ratio and bicarbonate (0.31 +/- 0.15) were moderate and positive. For pvO(2), the genetic correlation with heart ratio was stronger and negative (-0.62 +/- 0.21); however, this correlation could not be estimated accurately because of the low heritability of pvO(2). For pvCO(2), the genetic correlation with the heart ratio was close to zero (-0.04 +/- 0.45). Phenotypic correlations between traits were, in general, similar to the genetic correlations. Heritabilities for blood gas parameters and the genetic correlations between blood gas parameters and the heart ratio estimated in the present study

  20. Elemental analysis of some traditional herbal blood tonics and pharmaceutical blood tonics using INAA

    International Nuclear Information System (INIS)

    Iron content and some essential trace elements in six traditional Ghanaian herbal blood tonics and four pharmaceutical blood tonics have been determined using Thermal and Epithermal Instrumental Neutron Activation Analysis (TINAA and EINAA). The samples were irradiated in one inner and one outer irradiation sites of the Ghana research reactor-1 (GHARR-1) operating at a thermal neutron flux of 5.0x1011. After irradiation, the samples were counted directly using an N-type high purity Germanium (HPGe) detector. The qualitative and quantitative determination was achieved using the gamma ray spectrum analysis software SPAN5.0. In all, 26 chemical elements were measured. In the liquid form, the pharmaceutical blood tonics have higher amount of Fe than the traditional herbal blood tonics. But the Fe content in traditional blood tonics compare favourably with the pharmaceutical tonics when freeze-dried. There were more essential elements in the herbal tonics than the pharmaceutical ones (author)

  1. OPIC Greenhouse Gas Emissions Analysis Details

    Data.gov (United States)

    Overseas Private Investment Corporation — Summary project inventory with independent analysis to quantify the greenhouse gas ("GHG") emissions directly attributable to projects to which the Overseas Private...

  2. Exploring the applicability of equine blood to bloodstain pattern analysis.

    Science.gov (United States)

    Larkin, Bethany A J; Banks, Craig E

    2016-07-01

    Bloodstain pattern analysis (BPA) is the forensic application of the interpretation of distinct patterns which blood exhibits during a bloodletting incident, providing key evidence with its ability to map the sequence of events. Here, we explore the use of equine blood and investigate its suitability within the field of BPA. Blood is a complex fluid, and finding a suitable safe substitute to human blood that encompasses all of its characteristics has been the focus of many investigations. Animal blood has been concluded as the closest and therefore the most suitable alternate. However, it seems that currently only porcine blood is most prominently utilised.In this study, equine blood was investigated, using two different anti-clotting methods, where blood impacts were explored over a typical range of varying impact velocities upon a selection of commonly encountered surfaces. Key BPA parameters, such as the diameters of the resulting bloodstains, number of spines and area of origin were measured, which were subsequently applied into previously derived BPA equations.We find that defibrinated equine blood is a suitable alternative and offers the same conclusive outcomes to human blood. This gives bloodstain pattern investigators and researchers an additional choice of blood which can be of benefit when certain bloods are difficult to attain or when the activity involves the usage of a large quantity of blood. Additionally we explore the effect on BPA of aged blood, which revealed a significant decrease in stain diameter of up to 12.78 % when blood has been left for 57 days. A shelf life of no more than 12 days is recommended when blood is refrigerated at 4℃. PMID:25013163

  3. Gas chromatographic analysis of trace gas impurities in tungsten hexafluoride.

    Science.gov (United States)

    Laurens, J B; de Coning, J P; Swinley, J M

    2001-03-01

    Highly reactive fluorinated gaseous matrices require special equipment and techniques for the gas chromatographic analysis of trace impurities in these gases. The impurities that were analysed at the low-microg/l levels included oxygen, nitrogen, carbon dioxide, carbon monoxide, sulfur hexafluoride and hydrogen. This paper describes the use of a system utilising backflush column switching to protect the columns and detectors in the analysis of trace gas impurities in tungsten hexafluoride. Two separate channels were used for the analysis of H2, O2, N2, CO, CO2 and SF6 impurities with pulsed discharge helium ionisation detection. PMID:11269587

  4. Effects of Imidapril on Venous Blood Gas Values in Broiler Chickens Exposed to Low Ambient Temperature

    Institute of Scientific and Technical Information of China (English)

    Xueqin HAO; Meng LI; Shouyan ZHANG; Yongshu WANG; Tongwen SUN

    2013-01-01

    [Objective] This study was designed to evaluate the effects of imidapril on blood gas parameters in broiler chickens.[Method] Twenty-four chickens were randomly divided into three groups (n=8),control group,low temperature group and imidapril group.Chickens in low temperature group and imidapril group were exposed to low ambient temperature (12-18 ℃) from age at 14 d to 45 d,whereas the control group was exposed to 24-30 ℃; chickens in imidapril group were gavaged with imidapril (3 mg/kg) once daily for 30 d.At age of 45 d,blood was taken from wing vein and blood gas parameters were evaluated by blood gas analyzer in Luoyang Central Hospital Affiliated to Zhengzhou University.[Result] Imidapril significantly increased hematocrit (HCT) and total hemoglobin content (THBC) and blood Na concentration in broiler chickens exposed to low ambient temperature.No significant differences were observed in pH,Pco2,Po2,K+,Ca2+,HCO3-,HCO3std,Tco2,BE and SO2c.[Conclusion] Imidapril increases hematocrit,total hemoglobin content and blood Na+concentration in chickens exposed to low ambient temperature.

  5. Analysis of arterial blood gas for 113 patients with acute respiratory stress syndrome%急性呼吸窘迫综合征的动态血气监测113例分析

    Institute of Scientific and Technical Information of China (English)

    张玉梅; 周泽芬; 任成山

    2001-01-01

    目的 探讨动态监测血气对急性呼吸窘迫综合征(ARDS)的早期诊断、治疗和预后判断的临床意义。方法 回顾分析了我院16年间危重病患者并发ARDS 113例655例次动脉血气分析、酸碱紊乱类型和氧合指数(PaO2/FiO2)等资料。结果 (1)酸碱失衡类型:113例中单纯酸碱紊乱44例,含呼碱20例,呼酸11例,代酸10例,代碱3例;二重酸碱紊乱53例,含呼碱并代酸12例,呼碱并代碱14例,呼酸并代酸21例,呼酸并代碱6例;三重酸碱失衡(TABD)16例,含呼碱型TABD11例,呼酸型TABD5例。治愈各组以单纯呼碱(17例)和呼碱并代碱(12例)等类型多见;死亡组以呼酸并代酸(19例)、TABD(14例)、呼酸(9例)等类型多见;(2)氧合指数:113例患者的氧合指数均<26.7kPa;(3)113例ARDS治愈52例(46.0%),死亡61例(54.0%)。结论 通过对113例危重患者并发ARDS的血气分析,动态监测血气和计算氧合指数,对ARDS的早期诊断和治疗具有重要的临床价值,而正确分析、判断酸碱失衡类型是正确治疗和提高治愈率的重要环节。%Objective To explore the significance of dynamic determination of arterial blood gas for early diagnosis, treatment and prognosis of patients with acute respiratory stress syndrome(ARDS). Methods The results of 655 times arterial blood gas assayed in 113 patients with ARDS were analysed retrospectively.Results (1)Types of acid-basic disturbance:The simple acid-base disturbances were 44 cases,in which respiratory alkalosis were 20 cases, respiratory acidosis 11 cases, metabolic acidosis 10 cases, metabolic alkalosis 3 cases. Complex acid-base disturbances were 53 cases,in which respiratory alkalosis with metabolic acidosis were12 cases, respiratory alkalosis with metabolic alkalosis 14 cases, respiratory acidosis with metabolic acidosis 21 cases, respiratory alkalosis with metabolic alkalosis 6 cases. Triple acid-base disturbances (TABD) were 16

  6. Changes in electrolytes and blood gas after transfusion of irradiated MAP

    International Nuclear Information System (INIS)

    This study was undertaken to investigate the changes in recipient serum electrolytes and arterial blood gas after irradiated blood transfusion. We measured electrolytes and arterial blood gas before and after the transfusion during elective surgery in 55 patients. The mean blood loss was 1,477 g and the mean transfused blood unit of irradiated Mannitol-Adenine-Phosphate (MAP) was 5.9 units. Potassium concentration increased from 3.8 to 4.2 mEq·l-1. A total of 187 units, which had been stored for 12.3±3.5 days after donation and for 5.1±3.8 days after irradiation, was used. There was a significant correlation between the storage period from the day of irradiation and the potassium concentration of the supernatant (r=0.56, p<0.0001). This study recommends that a safe transfusion rate of irradiated blood should be determined because the high potassium concentration of irradiated blood may lead to lethal complications in case of rapid transfusion. (author)

  7. Changes in electrolytes and blood gas after transfusion of irradiated MAP

    Energy Technology Data Exchange (ETDEWEB)

    Miyao, Hideki; Katayama, Akinori; Okamoto, Yumi; Koyama, Kaoru; Kawasaki, Jun; Kawazoe, Taro [Saitama Medical School, Kawagoe (Japan). Saitama Medical Center

    2001-09-01

    This study was undertaken to investigate the changes in recipient serum electrolytes and arterial blood gas after irradiated blood transfusion. We measured electrolytes and arterial blood gas before and after the transfusion during elective surgery in 55 patients. The mean blood loss was 1,477 g and the mean transfused blood unit of irradiated Mannitol-Adenine-Phosphate (MAP) was 5.9 units. Potassium concentration increased from 3.8 to 4.2 mEq{center_dot}l{sup -1}. A total of 187 units, which had been stored for 12.3{+-}3.5 days after donation and for 5.1{+-}3.8 days after irradiation, was used. There was a significant correlation between the storage period from the day of irradiation and the potassium concentration of the supernatant (r=0.56, p<0.0001). This study recommends that a safe transfusion rate of irradiated blood should be determined because the high potassium concentration of irradiated blood may lead to lethal complications in case of rapid transfusion. (author)

  8. Effect of stratified inequality of blood flow on gas exchange in liquid-filled lungs.

    Science.gov (United States)

    West, J. B.; Maloney, J. E.; Castle, B. L.

    1972-01-01

    This investigation set out to answer two questions: (1) are the distal alveoli in the terminal lung units less well perfused than the proximal alveoli, i.e., is there stratification of blood flow; and (2) if so, does this enhance gas exchange in the presence of stratified inequality of ventilation. Excised dog lungs were ventilated with saline and perfused with blood. Following single inspirations of xenon 133 in saline and various periods of breath holding, the expired xenon concentration against volume was measured and it confirmed marked stratified inequality of ventilation under these conditions. By measuring the rate of depletion of xenon from alveoli during a period of blood flow, we showed that the alveoli which emptied at the end of expiration had 16% less blood flow than those exhaling earlier. However, by measuring the xenon concentration in pulmonary venous blood, we found that about 10% less tracer was transferred from the alveoli into the blood when the inspired xenon was stratified within the respiratory zone. Thus while stratification of blood flow was confirmed, it was shown to impair rather than enhance the efficiency of gas transfer.

  9. Oscillometric blood pressure measurements: A signal analysis

    Science.gov (United States)

    Barbé, K.; Van Moer, W.; Lauwers, L.

    2010-07-01

    In this paper, the oscillometric waveform measured by automatic non-invasive blood pressure meters (NIBP) is analyzed by transforming the data from the time domain to the frequency domain. The signal's spectrum of the oscillometric waveform is in current literature badly understood or explored. The only known link between the oscillometric waveform and the blood pressure is the maximum of the oscillometry's envelope equalling the mean arterial pressure (MAP). This link is established under the assumption that the oscillometry is an AM-signal. Unfortunately, computing the MAP is difficult in practice due to the non-sinusoidal nature of the actual measured signals. In this paper, we construct the best AM-signal approximation of the oscillometry and explore its use to compute the MAP.

  10. Optical analysis of red blood cell suspension

    Science.gov (United States)

    Szołna, Alicja A.; Grzegorzewski, Bronisław

    2008-12-01

    The optical properties of suspensions of red blood cells (RBCs) were studied. Fresh human venues blood was obtained from adult healthy donors. RBCs were suspended in isotonic salt solution, and in autologous plasma. Suspensions with haematocrit 0.25 - 3% were investigated. Novel technique was proposed to determine the scattering coefficient μs for the suspensions. The intensity of He-Ne laser light transmitted through a wedge-shape container filled with a suspension was recorded. To find the dependence of the intensity on the thickness of the sample the container was moved horizontally. The dependence of μs on the haematocrit was determined for RBCs suspended in the isotonic salt solution. RBCs suspended in plasma tend to form rouleaux. For the RBCs suspended in plasma, the scattering coefficient as a function of time was obtained. It is shown that this technique can be useful in the study of rouleaux formation.

  11. Analysis of blood plasma at terahertz frequencies

    Science.gov (United States)

    Cherkasova, O. P.; Nazarov, M. M.; Angeluts, A. A.; Shkurinov, A. P.

    2016-01-01

    Terahertz time-domain spectroscopy in the 0.05-2.5 THz frequency range was employed to analyze blood plasma samples obtained from laboratory animals with experimental diabetes and from healthy controls. It was found that transmission and reflection coefficients of samples from rats with diabetes differed significantly from control values in both amplitude and phase. The cause of the detected differences is discussed with respect to variation in the terahertz response of water.

  12. Analysis of blood spots for polyfluoroalkyl chemicals

    International Nuclear Information System (INIS)

    Polyfluoroalkyl chemicals (PFCs) have been detected in humans, in the environment, and in ecosystems around the world. The potential for developmental and reproductive toxicities of some PFCs is of concern especially to children's health. In the United States, a sample of a baby's blood, called a 'dried blood spot' (DBS), is obtained from a heel stick within 48 h of a child's birth. DBS could be useful for assessing prenatal exposure to PFCs. We developed a method based on online solid phase extraction coupled with high performance liquid chromatography-isotope dilution tandem mass spectrometry for measuring four PFCs in DBS, perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate, perfluorooctanoate (PFOA), and perfluorononanoate. The analytical limits of detection using one whole DBS (∼75 μL of blood) were -1. To validate the method, we analyzed 98 DBS collected in May 2007 in the United States. PFOS and PFOA were detected in all DBS at concentrations in the low ng mL-1 range. These data suggest that DBS may be a suitable matrix for assessing perinatal exposure to PFCs, but additional information related to sampling and specimen storage is needed to demonstrate the utility of these measures for assessing exposure.

  13. Microfluidic Cytometer for Complete Blood Count Analysis Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We will fabricate and test microfluidic designs for a micro-electromechanical system based complete blood count (CBC) analysis in separate modules and integrate...

  14. Mathematical modeling of blood-gas kinetics for the volatile organic compounds isoprene and acetone

    International Nuclear Information System (INIS)

    Breath gas analysis is based on the compelling concept that the exhaled breath levels of endogenously produced volatile organic compounds (VOCs) can provide a direct, non-invasive window to the blood and hence, by inference, to the body. In this sense, breath VOCs are regarded as a comprehensive repository of valuable physiological and clinical information, that might be exploited in such diverse areas as diagnostics, therapeutic monitoring or general dynamic assessments of metabolic function, pharmacodynamics (e.g., in drug testing) and environmental exposure (e.g., in occupational health). Despite this enormous potential, the lack of standardized breath sampling regimes as well as the poor mechanistic understanding of VOC exhalation kinetics could cast a cloud over the widespread use of breath gas analysis in the biomedical sciences. In this context, a primary goal of the present thesis is to provide a better quantitative insight into the breath behavior of two prototypic VOCs, isoprene and acetone. A compartmental modeling framework is developed and validated by virtue of real-time breath measurements of these trace gases during distinct physiological states. In particular, the influence of various hemodynamic and ventilatory parameters on VOC concentrations in exhaled breath is investigated. This approach also complements previous steady state investigations in toxicology. From a phenomenological point of view, both acetone and isoprene concentrations in end-tidal breath are demonstrated to exhibit a reproducible non-steady state behavior during moderate workload challenges on a stationary bicycle. However, these dynamics depart drastically from what is expected on the basis of classical pulmonary inert gas elimination theory. More specifically, the start of exercise is accompanied by an abrupt increase in breath isoprene levels, usually by a factor of 3 to 4 compared with the steady state value during rest. This phase is followed by a gradual decline and the

  15. Dexmedetomidine on the hemodynamics and blood gas analysis in morbidly obese patients with obstructive sleep apnea%右美托咪定对病态肥胖的阻塞性睡眠呼吸暂停综合征患者的血气分析

    Institute of Scientific and Technical Information of China (English)

    葛云芬; 胡双飞

    2012-01-01

    目的 评价右美托咪定对病态肥胖的阻塞性睡眠呼吸暂停综合征患者血气分析的影响.方法 40例ASAⅢ级欲行悬雍垂腭咽成形术的病态肥胖的阻塞性睡眠呼吸暂停综合征患者,随机分成右美托咪定组和安慰剂组,右美托咪定组给予负荷剂量1 μg· kg-1(20 min)的右美托咪定,安慰剂组则给予容量和外形相似的生理盐水.观察用药后患者的血流动力学及用药前后血气分析的变化.结果 右美托咪定组20 min后的心率(HR)、平均血压(BP)、血氧分压(PaO2)与安慰剂组相比显著降低;二氧化碳分压(PaCO2)及pH值与安慰剂组相比差异无统计学意义.结论 短时间内大剂量的右美托咪定应用于病态肥胖的阻塞性睡眠呼吸暂停综合征患者也可以产生呼吸抑制.%Objective To assess the effect of dexmedetomidine on the hemodynamics and blood gas analysis in morbidly obese patients with obstructive sleep apnea. Methods Forty patients scheduled for uvulo palatopharyngoplasty were randomized assigned into receive dexmedetomidine group or placebo group, respectively. In dexmedtomidine group patients received a loading dose of dexmedetomidine 1 μg ? Kg-1 during 20 minutes, In placebo group patients received a volume matched 0. 9% saline. Heart rate ( HR) , blood pressure ( BP)' and blood gas analysis were monitored. Results HR, mean arterial blood pressure and arterial PaO2 presented a statistically significant reduction in the dexmedetomidine group after 20 minutes as compared to the placebo group. Blood PaCO2 and pH were similar for both groups. Conclusion Dexmedetomidine produced respiratory depression in morbidly obese patients with obstructive sleep apnea.

  16. Determination of ketone bodies in blood by headspace gas chromatography-mass spectrometry

    DEFF Research Database (Denmark)

    Holm, Karen Marie Dollerup; Linnet, Kristian; Rasmussen, Brian Schou;

    2010-01-01

    A gas chromatography-mass spectrometry (GC-MS) method for determination of ketone bodies (ß-hydroxybutyrate, acetone, and acetoacetate) in blood is presented. The method is based on enzymatic oxidation of D-ß-hydroxybutyrate to acetoacetate, followed by decarboxylation to acetone, which was...

  17. Effects of ambient air particulate exposure on blood-gas barrier permeability and lung function

    DEFF Research Database (Denmark)

    Bräuner, Elvira Vaclavik; Mortensen, Jann; Møller, Peter;

    2009-01-01

    Particulate air pollution is associated with increased risk of pulmonary diseases and detrimental outcomes related to the cardiovascular system, including altered vessel functions. This study's objective was too evaluate the effects of ambient particle exposure on the blood-gas permeability, lung...... effect on the concentration of CC16 in plasma and urine or on the static and dynamic volumes or ventilation distribution of the lungs. The study thus demonstrates increased permeability of the alveolar blood-gas barrier following moderate exercise, whereas exposure to ambient levels of urban air.......5-15.8 microg/m(3) PM(10-2.5)) or filtered (91-542 particles/cm(3)) air collected above a busy street. The clearance rate of aerosolized (99m)Tc-labeled diethylenetriamine pentaacetic acid ((99m)Tc-DTPA) was measured as an index for the alveolar epithelial membrane integrity and permeability of the lung blood...

  18. Classification of High Blood Pressure Persons Vs Normal Blood Pressure Persons Using Voice Analysis

    Directory of Open Access Journals (Sweden)

    Saloni

    2013-11-01

    Full Text Available The human voice is remarkable, complex and delicate. All parts of the body play some role in voice production and may be responsible for voice dysfunction. The larynx contains muscles that are surrounded by blood vessels connected to circulatory system. The pressure of blood in these vessels should be related with dynamic variation of vocal cord parameters. These parameters are directly related with acoustic properties of speech. Acoustic voice analysis can be used to characterize the pathological voices. This paper presents the classification of high blood pressure and normal with the aid of voice signal recorded from the patients. Various features have been extracted from the voice signal of healthy persons and persons suffering from high blood pressure. Simulation results show differences in the parameter values of healthy and pathological persons. Then an optimum feature vector is prepared and kmean classification algorithm was implemented for data classification. The 79% classification efficiency was obtained.

  19. Automated red blood cell analysis compared with routine red blood cell morphology by smear review

    Directory of Open Access Journals (Sweden)

    Dr.Poonam Radadiya

    2015-01-01

    Full Text Available The RBC histogram is an integral part of automated haematology analysis and is now routinely available on all automated cell counters. This histogram and other associated complete blood count (CBC parameters have been found abnormal in various haematological conditions and may provide major clues in the diagnosis and management of significant red cell disorders. Performing manual blood smears is important to ensure the quality of blood count results and to make presumptive diagnosis. In this article we have taken 100 samples for comparative study between RBC histograms obtained by automated haematology analyzer with peripheral blood smear. This article discusses some morphological features of dimorphism and the ensuing characteristic changes in their RBC histograms.

  20. Permanent gas analysis using gas chromatography with vacuum ultraviolet detection.

    Science.gov (United States)

    Bai, Ling; Smuts, Jonathan; Walsh, Phillip; Fan, Hui; Hildenbrand, Zacariah; Wong, Derek; Wetz, David; Schug, Kevin A

    2015-04-01

    The analysis of complex mixtures of permanent gases consisting of low molecular weight hydrocarbons, inert gases, and toxic species plays an increasingly important role in today's economy. A new gas chromatography detector based on vacuum ultraviolet (VUV) spectroscopy (GC-VUV), which simultaneously collects full scan (115-240 nm) VUV and UV absorption of eluting analytes, was applied to analyze mixtures of permanent gases. Sample mixtures ranged from off-gassing of decomposing Li-ion and Li-metal batteries to natural gas samples and water samples taken from private wells in close proximity to unconventional natural gas extraction. Gas chromatography separations were performed with a porous layer open tubular column. Components such as C1-C5 linear and branched hydrocarbons, water, oxygen, and nitrogen were separated and detected in natural gas and the headspace of natural gas-contaminated water samples. Of interest for the transport of lithium batteries were the detection of flammable and toxic gases, such as methane, ethylene, chloromethane, dimethyl ether, 1,3-butadiene, CS2, and methylproprionate, among others. Featured is the capability for deconvolution of co-eluting signals from different analytes. PMID:25724098

  1. Analysis of K west basin canister gas

    Energy Technology Data Exchange (ETDEWEB)

    Trimble, D.J., Fluor Daniel Hanford

    1997-03-06

    Gas and Liquid samples have been collected from a selection of the approximately 3,820 spent fuel storage canisters in the K West Basin. The samples were taken to characterize the contents of the gas and water in the canisters providing source term information for two subprojects of the Spent Nuclear Fuel Project (SNFP) (Fulton 1994): the K Basins Integrated Water Treatment System Subproject (Ball 1996) and the K Basins Fuel Retrieval System Subproject (Waymire 1996). The barrels of ten canisters were sampled for gas and liquid in 1995, and 50 canisters were sampled in a second campaign in 1996. The analysis results from the first campaign have been reported (Trimble 1995a, 1995b, 1996a, 1996b). The analysis results from the second campaign liquid samples have been documented (Trimble and Welsh 1997; Trimble 1997). This report documents the results for the gas samples from the second campaign and evaluates all gas data in terms of expected releases when opening the canisters for SNFP activities. The fuel storage canisters consist of two closed and sealed barrels, each with a gas trap. The barrels are attached at a trunion to make a canister, but are otherwise independent (Figure 1). Each barrel contains up to seven N Reactor fuel element assemblies. A gas space of nitrogen was established in the top 2.2 to 2.5 inches (5.6 to 6.4 cm) of each barrel. Many of the fuel elements were damaged allowing the metallic uranium fuel to be corroded by the canister water. The corrosion releases fission products and generates hydrogen gas. The released gas mixes with the gas-space gas and excess gas passes through the gas trap into the basin water. The canister design does not allow canister water to be exchanged with basin water.

  2. 中心静脉和动脉血气联合分析在脓毒血症患者诊疗中的预警作用%PRECAUTION OF CENTRAL VENOUS AND ARTERIAL BLOOD GAS ASSOCIATED ANALYSIS IN PATIENTS WITH SEPSIS

    Institute of Scientific and Technical Information of China (English)

    卜会驹; 杨秀洁; 杭寒皎; 陈亮

    2009-01-01

    目的 探讨中心静脉和动脉血气联合分析在脓毒血症患者诊疗中的应用价值.方法 脓毒血症患者46例,定时进行中心静脉和动脉血气分析,记录相关数据,同时记录中心静脉压(CVP)、平均动脉压(MAP)、每小时尿量.根据3d后APACHEⅢ评分是否≥80,分为A组(23例)、B组(23例),比较入院时的APACHEⅢ评分,动脉血气,静脉血气.根据治疗过程中是否发生休克,分为C组(17例)、D组(29例),比较休克前一次的动脉和静脉血气.3d后,选择生命体征平稳,疗效较好的患者,设定为E组(16例),比较每个时段的动静脉血氧饱和度,CVP、MAP、尿量变化.结果 A,B二组患者入科时,APACHEⅢ评分、动脉血气分析各项指标无差异,但静脉血气氧分压、二氧化碳分压、pH值、A-VpH(动静脉pH值差),A-VPCO2(动静脉二氧化碳分压差)差异有统计学意义(P<0.05).D组患者休克发生前血气与无休克患者比较,动脉血气值差异无统计学意义,但是A-VpH,A-VPCO2和静脉血气分析各项数据差异有统计学意义(P<0.05).在E组患者中,随着病情好转,A-VpH,A-VPCO2和静脉氧饱和度比MAP、CVP、每小时尿量等数据更快出现改善(P<0.05).结论 中心静脉和动脉血气联合分析在脓毒血症患者诊疗中,有早期判断预后,提示休克发生,快速判断疗效等几大预警作用.%Objective To investigate the precaution of central venous and arterial blood gas associated analysis in the diagnosis and treatment of patients with sepsis. Methods 46 sepsis patients were recruited, central venous blood gas and arterial gas values, central venous pressure(CVP),average arterial pressure (MAP),quantities of urine per hour were timed and recorded. Based on APACHE Ⅲ grade exceed 80 or not after 3 days , patients were divided into two groups: group A(23 cases),group B(23 cases),compared the first APACHEⅢgrade, central venous blood gas and arterial gas value of these groups. Based on

  3. Cardiac Morphology and Function, and Blood Gas Transport in Aquaporin-1 Knockout Mice

    Science.gov (United States)

    Al-Samir, Samer; Wang, Yong; Meissner, Joachim D.; Gros, Gerolf; Endeward, Volker

    2016-01-01

    We have studied cardiac and respiratory functions of aquaporin-1-deficient mice by the Pressure-Volume-loop technique and by blood gas analysis. In addition, the morphological properties of the animals' hearts were analyzed. In anesthesia under maximal dobutamine stimulation, the mice exhibit a moderately elevated heart rate of < 600 min−1 and an O2 consumption of ~0.6 ml/min/g, which is about twice the basal rate. In this state, which is similar to the resting state of the conscious animal, all cardiac functions including stroke volume and cardiac output exhibited resting values and were identical between deficient and wildtype animals. Likewise, pulmonary and peripheral exchange of O2 and CO2 were normal. In contrast, several morphological parameters of the heart tissue of deficient mice were altered: (1) left ventricular wall thickness was reduced by 12%, (2) left ventricular mass, normalized to tibia length, was reduced by 10–20%, (3) cardiac muscle fiber cross sectional area was decreased by 17%, and (4) capillary density was diminished by 10%. As the P-V-loop technique yielded normal end-diastolic and end-systolic left ventricular volumes, the deficient hearts are characterized by thin ventricular walls in combination with normal intraventricular volumes. The aquaporin-1-deficient heart thus seems to be at a disadvantage compared to the wild-type heart by a reduced left-ventricular wall thickness and an increased diffusion distance between blood capillaries and muscle mitochondria. While under the present quasi-resting conditions these morphological alterations have no consequences for cardiac function, we expect that the deficient hearts will show a reduced maximal cardiac output. PMID:27252655

  4. Analysis for blood manganese used to assess environmental exposure

    Energy Technology Data Exchange (ETDEWEB)

    Hams, G.A.; Fabri, J.K.

    1988-06-01

    In this graphite-furnace atomic-absorption spectrometric method for measuring manganese in whole blood, we use a pyrolytic platform to minimize interference by sample matrix. For optimal sample ashing we denature the sample within the furnace with nitric acid and use oxygen as the purge gas at low temperatures. The mean manganese concentration found in blood from 15 unexposed city dwellers was 215 (2 SD 135) nmol/L. By comparison, the range of manganese concentrations in blood sampled from a group of Australian aborigines living near a surface manganese ore deposit on Groote Eylandt, Northern Territory, was much higher (median 405 nmol/L, range 175 to 990 nmol/L).

  5. Wavelet-analysis for Laser Images of Blood Plasma

    Directory of Open Access Journals (Sweden)

    ANGELSKY, A.-P.

    2011-05-01

    Full Text Available The possibilities of the local wavelet-analysis of polarization-inhomogeneous laser image of human blood plasma were considered. The set of statistics, correlation and fractal parameters of the distributions of wavelet-coefficients that are characterize different scales of the polarization maps of polycrystalline networks of amino acids of blood plasma were defined. The criteria for the differentiation of the transformation of birefringence optical-anisotropic structures of blood plasma at different scales of their geometric dimensions were determined.

  6. Dried blood spot analysis ; facing new challenges

    NARCIS (Netherlands)

    Koster, Remco A; Touw, Daan J; Alffenaar, Jan-willem C

    2015-01-01

    Over the last decade, DBS analysis has gained popularity for TDM because it’s a patient friendly sampling proce- dure [1-4]. Additional advantages are prolonged sample stability, lower risk of infections and transportation at ambient temperature [1-3,5]. These advantages may fa- cilitate implementat

  7. Does chocolate reduce blood pressure? A meta-analysis

    Directory of Open Access Journals (Sweden)

    Ried Karin

    2010-06-01

    Full Text Available Abstract Background Dark chocolate and flavanol-rich cocoa products have attracted interest as an alternative treatment option for hypertension, a known risk factor for cardiovascular disease. Previous meta-analyses concluded that cocoa-rich foods may reduce blood pressure. Recently, several additional trials have been conducted with conflicting results. Our study summarises current evidence on the effect of flavanol-rich cocoa products on blood pressure in hypertensive and normotensive individuals. Methods We searched Medline, Cochrane and international trial registries between 1955 and 2009 for randomised controlled trials investigating the effect of cocoa as food or drink compared with placebo on systolic and diastolic blood pressure (SBP/DBP for a minimum duration of 2 weeks. We conducted random effects meta-analysis of all studies fitting the inclusion criteria, as well as subgroup analysis by baseline blood pressure (hypertensive/normotensive. Meta-regression analysis explored the association between type of treatment, dosage, duration or baseline blood pressure and blood pressure outcome. Statistical significance was set at P Results Fifteen trial arms of 13 assessed studies met the inclusion criteria. Pooled meta-analysis of all trials revealed a significant blood pressure-reducing effect of cocoa-chocolate compared with control (mean BP change ± SE: SBP: -3.2 ± 1.9 mmHg, P = 0.001; DBP: -2.0 ± 1.3 mmHg, P = 0.003. However, subgroup meta-analysis was significant only for the hypertensive or prehypertensive subgroups (SBP: -5.0 ± 3.0 mmHg; P = 0.0009; DBP: -2.7 ± 2.2 mm Hg, P = 0.01, while BP was not significantly reduced in the normotensive subgroups (SBP: -1.6 ± 2.3 mmHg, P = 0.17; DBP: -1.3 ± 1.6 mmHg, P = 0.12. Nine trials used chocolate containing 50% to 70% cocoa compared with white chocolate or other cocoa-free controls, while six trials compared high- with low-flavanol cocoa products. Daily flavanol dosages ranged from 30

  8. Systemic Metabolomic Changes in Blood Samples of Lung Cancer Patients Identified by Gas Chromatography Time-of-Flight Mass Spectrometry

    Directory of Open Access Journals (Sweden)

    Suzanne Miyamoto

    2015-04-01

    Full Text Available Lung cancer is a leading cause of cancer deaths worldwide. Metabolic alterations in tumor cells coupled with systemic indicators of the host response to tumor development have the potential to yield blood profiles with clinical utility for diagnosis and monitoring of treatment. We report results from two separate studies using gas chromatography time-of-flight mass spectrometry (GC-TOF MS to profile metabolites in human blood samples that significantly differ from non-small cell lung cancer (NSCLC adenocarcinoma and other lung cancer cases. Metabolomic analysis of blood samples from the two studies yielded a total of 437 metabolites, of which 148 were identified as known compounds and 289 identified as unknown compounds. Differential analysis identified 15 known metabolites in one study and 18 in a second study that were statistically different (p-values <0.05. Levels of maltose, palmitic acid, glycerol, ethanolamine, glutamic acid, and lactic acid were increased in cancer samples while amino acids tryptophan, lysine and histidine decreased. Many of the metabolites were found to be significantly different in both studies, suggesting that metabolomics appears to be robust enough to find systemic changes from lung cancer, thus showing the potential of this type of analysis for lung cancer detection.

  9. Non-arterial assessment of blood gas status in patients with chronic pulmonary disease.

    OpenAIRE

    Elborn, J. S.; Finch, M B; Stanford, C. F.

    1991-01-01

    Assessment of blood gas status is important in the management of patients with chronic pulmonary disease. Arterial puncture is often painful and may damage the arterial wall. Measurement of oxygen saturation by transcutaneous oximetry offers a non-invasive alternative to arterial methods but does not allow assessment of partial pressure of carbon dioxide. We have examined the value of oximetry and dorsal hand venous carbon dioxide as an alternative to arterial puncture. Transcutaneous oxygen ...

  10. 20 CFR Appendix C to Part 718 - Blood-Gas Tables

    Science.gov (United States)

    2010-04-01

    ... level: Arterial PCO2 (mm Hg) Arterial PO2 equal to or less than (mm Hg) 25 or below 75 26 74 27 73 28 72...: Arterial PCO2 (mm Hg) Arterial PO2 equal to or less than (mm Hg) 25 or below 70 26 69 27 68 28 67 29 66 30... arterial blood-gas studies performed at test sites 6,000 feet or more above sea level: Arterial PCO2 (mm...

  11. The use of blood gas parameters to predict ascites susceptibility in juvenile broilers.

    Science.gov (United States)

    van As, P; Elferink, M G; Closter, A M; Vereijken, A; Bovenhuis, H; Crooijmans, R P M A; Decuypere, E; Groenen, M A M

    2010-08-01

    Ascites syndrome is a metabolic disorder found in modern broilers that have insufficient pulmonary vascular capacity. Commercial breeding programs have heavily focused on high growth rate, which led to fast-growing chickens, but as a negative consequence, the incidence of ascites syndrome increased. However, not all birds with a high growth rate will suffer from ascites syndrome, which might indicate a genetic susceptibility to ascites. Information on blood gas parameters measured early in life and their relation to ascites susceptibility is expected to contribute to identification on the cause of ascites syndrome. In this study, several physiological parameters, such as blood gas parameters [pH, partial pressure of CO(2) in venous blood (pvCO(2)), and partial pressure of O(2) in venous blood], hematocrit, electrolytes (Na(+), Ca(2+), and K(+)), metabolites (lactate and glucose), were measured at d 11 to 12 of age from 100 female and 100 male broilers. From d 14 onward, the birds were challenged to provoke the development of ascites syndrome. Our results showed that high pvCO(2) values together with low pH values (males) or high pH values (females) in the venous blood of juvenile broilers coincided with ascites. Therefore, blood pvCO(2) and pH in both juvenile male and female broilers seem to be critical factors in ascites pathophysiology and can be used as phenotypic traits to predict ascites susceptibility in juvenile broilers at d 11 to 12. A prediction model was built on a subpopulation of the broilers without any loss in sensitivity (0.52) and specificity (0.78) when applied to the validation population. The parameter sex was included in the prediction model because levels of pvCO(2) and pH that associated with ascites susceptibility are different between males and females. Commercial breeders can include these phenotypic traits in their genetic selection programs to reduce the incidence of ascites syndrome. PMID:20634524

  12. Congenital Hypothyroidism Screening with Umbilical Cord Blood: Retrospective Analysis.

    Science.gov (United States)

    Anand, M R; Ramesh, Preetha; Nath, Divia

    2015-05-01

    Incidence of congenital hypothyroidism varies across countries and different geographic regions. A retrospective analysis of cord blood thyroid stimulating hormone values, and their subsequent follow-up, was done in a tertiary-care center in Kerala, India. Congenital hypothyroidism was found at the rate of 1 in 244, which is higher than reported incidence from other centers. PMID:26061935

  13. Finite-sized gas bubble motion in a blood vessel: non-Newtonian effects.

    Science.gov (United States)

    Mukundakrishnan, Karthik; Ayyaswamy, Portonovo S; Eckmann, David M

    2008-09-01

    We have numerically investigated the axisymmetric motion of a finite-sized nearly occluding air bubble through a shear-thinning Casson fluid flowing in blood vessels of circular cross section. The numerical solution entails solving a two-layer fluid model--a cell-free layer and a non-Newtonian core together with the gas bubble. This problem is of interest to the field of rheology and for gas embolism studies in health sciences. The numerical method is based on a modified front-tracking method. The viscosity expression in the Casson model for blood (bulk fluid) includes the hematocrit [the volume fraction of red blood cells (RBCs)] as an explicit parameter. Three different flow Reynolds numbers, Reapp=rholUmaxdmicroapp , in the neighborhood of 0.2, 2, and 200 are investigated. Here, rhol is the density of blood, Umax is the centerline velocity of the inlet Casson profile, d is the diameter of the vessel, and microapp is the apparent viscosity of whole blood. Three different hematocrits have also been considered: 0.45, 0.4, and 0.335. The vessel sizes considered correspond to small arteries, and small and large arterioles in normal humans. The degree of bubble occlusion is characterized by the ratio of bubble to vessel radius (aspect ratio), lambda , in the range 0.9 - --> +) imparted to the cell surface during bubble motion; (iii) large shear stress gradients together with sign reversals are ascribable to the development of a recirculation vortex at the rear of the bubble; (iv) computed magnitudes of shear stress gradients coupled with their sign reversals may correspond to levels that cause injury to the cell by membrane disruption through impulsive compression and stretching; and (v) for the vessel sizes and flow rates investigated, gravitational effects are negligible. PMID:18851139

  14. Performance Analysis of Retinal Image Blood Vessel Segmentation

    Directory of Open Access Journals (Sweden)

    D.Siva Sundhara Raja

    2014-06-01

    Full Text Available The retinal image diagnosis is an important methodology for diabetic retinopathy detection and analysis. in this paper, the morphological operations and svm classifier are used to detect and segment the blood vessels from the retinal image. the proposed system consists of three stages-first is preprocessing of retinal image to separate the green channel and second stage is retinal image enhancement and third stage is blood vessel segmentation using morphological operations and svm classifier. the performance of the proposed system is analyzed using publicly available dataset.

  15. Automatic analysis of microscopic images of red blood cell aggregates

    Science.gov (United States)

    Menichini, Pablo A.; Larese, Mónica G.; Riquelme, Bibiana D.

    2015-06-01

    Red blood cell aggregation is one of the most important factors in blood viscosity at stasis or at very low rates of flow. The basic structure of aggregates is a linear array of cell commonly termed as rouleaux. Enhanced or abnormal aggregation is seen in clinical conditions, such as diabetes and hypertension, producing alterations in the microcirculation, some of which can be analyzed through the characterization of aggregated cells. Frequently, image processing and analysis for the characterization of RBC aggregation were done manually or semi-automatically using interactive tools. We propose a system that processes images of RBC aggregation and automatically obtains the characterization and quantification of the different types of RBC aggregates. Present technique could be interesting to perform the adaptation as a routine used in hemorheological and Clinical Biochemistry Laboratories because this automatic method is rapid, efficient and economical, and at the same time independent of the user performing the analysis (repeatability of the analysis).

  16. HD gas analysis with Gas Chromatography and Quadrupole Mass Spectrometer

    CERN Document Server

    Ohta, T; Didelez, J -P; Fujiwara, M; Fukuda, K; Kohri, H; Kunimatsu, T; Morisaki, C; Ono, S; Rouille, G; Tanaka, M; Ueda, K; Uraki, M; Utsuro, M; Wang, S Y; Yosoi, M

    2011-01-01

    A gas analyzer system has been developed to analyze Hydrogen-Deuteride (HD) gas for producing frozen-spin polarized HD targets, which are used for hadron photoproduction experiments at SPring-8. Small amounts of ortho-H$_{2}$ and para-D$_{2}$ gas mixtures ($\\sim$0.01%) in the purified HD gas are a key to realize a frozen-spin polarized target. In order to obtain reliable concentrations of these gas mixtures in the HD gas, we produced a new gas analyzer system combining two independent measurements with the gas chromatography and the QMS. The para-H$_{2}$, ortho-H$_{2}$, HD, and D$_{2}$ are separated using the retention time of the gas chromatography and the mass/charge. It is found that the new gas analyzer system can measure small concentrations of $\\sim$0.01% for the otho-H$_2$ and D$_2$ with good S/N ratios.

  17. Umbilical artery blood gas analysis in the diagnosis of multiple organ damage of neonatal asphyxia%新生儿脐动脉血气分析在新生儿窒息多器官损害诊断中的应用

    Institute of Scientific and Technical Information of China (English)

    全国新生儿窒息多器官损害临床诊断多中心研究协作组

    2016-01-01

    Objective To study the relationship between umbilical arterial blood gas analysis and perinatal high risk factors, Apgar score and multiple organ damage of neonatal asphyxia. Methods Clinical data of cases of neonatal asphyxia in from the Neonatal Department and Intensive Care Unit of our research group from November 2012 to December 2014 were studied. Full term infants and premature infants ( gestational age >34 weeks, birth weight >2500 g) with neonatal asphyxia, whose umbilical artery blood gas analysis ( including pH and BE) were tested were enrolled in our study. Neonatal asphyxia was diagnosed according to the Apgar score, umbilical artery blood gas analysis, mild asphyxia group and severe asphyxia group were assigned into three groups respectively: severe metabolic acidosis group: pH≤7 and/or BE≤-16 mmol/L; non-severe metabolic acidosis group:77. 2, BE> -8 mmol/L. The diagnosis of multiple organ damage of neonatal asphyxia was made according to the history of perinatal hypoxia,clinical manifestations,laboratory examination and imaging examination.Results Therewere 111 cases in our study ( mild asphyxia: n =79 , severe asphyxia: n =32 ) . ( 1 ) The pH and BE of umbilical artery blood gas were positively related to 1 minute Apgar score ( pH: r=0. 223, P=0. 016;BE: r=0. 293, P=0. 002). (2) Multi-factor analysis of umbilical artery blood pH and BE showed that abnormal fetal heart rate was an important factor (β =0. 080 , 95℅ CI 0. 010 -0. 160 , P =0. 025 ) . (3) The incidence of multiple organ damage in severe asphyxia group was significantly higher than that in mild asphyxia group (75. 0℅ vs. 29. 1℅, Χ2 =17. 810, P34周、生后检测脐动脉血pH和BE的窒息新生儿,根据Apgar评分诊断新生儿窒息,根据脐血血气分析将轻度窒息组和重度窒息组分别分为严重代谢性酸中毒组(pH≤7和/或BE≤-16mmol/L)、非严重代谢性酸中毒组(77.2且BE>-8).根据围产期缺氧病史、临床表现、实验室检查和影

  18. Operating cost analysis aids gas turbine selection

    Energy Technology Data Exchange (ETDEWEB)

    Roy, G.K. [PT Indo-Rama Synthetics tbk., Purwakarta (Indonesia)

    1998-02-01

    If one considers the design life of a gas turbine to be 20 years, probably more than 70% of the plant operating costs will consist of fuel. And as fuel cost varies geographically, it is obvious that choosing a gas turbine, or for that matter any other prime mover, will depend on the fuel cost prevailing in that country. Spreadsheets make the analysis easier. A few options are presented to show the possible variations. The data taken for examples are typical. To illustrate the options, a typical requirement has been suggested for a plant--an electric power requirement of 50 MW and a process steam requirement of 70 tph. The selected gas/steam turbines, or diesel engine, will generate the electric power. When the equipment is down, the state electrical grid will provide the power.

  19. Effects of SO2 and pH on blood-gas partition coefficients of inert gases.

    Science.gov (United States)

    Yamaguchi, K; Mori, M; Kawai, A; Asano, K; Takasugi, T; Umeda, A; Yokoyama, T

    1990-01-01

    Potential effects of SO2 and of pH on blood-gas partition coefficients, lambda, for inert gases, including SF6, ethane, cyclopropane, halothane, diethyl ether, acetone and N2, were systematically investigated using human blood. Measurements on lambda were performed at 37 degrees C in conditions of varied SO2 and pH using gas chromatography. Incorporating the experimental data on lambda, multiple inert gas elimination was applied to 18 patients with varied chronic lung diseases, in order to estimate the effects of SO2 and of pH on both inert gas exchange and resultant recovery of VA/Q distribution in the lung. For this purpose, the data obtained by the procedure of multiple inert gas elimination were analyzed with the classical approach but allowance was made for lambda of the indicator gas to vary according to exchange of O2 and of CO2 in the pulmonary capillary. Among the gases studied, ethane, cyclopropane, halothane and diethyl ether showed significantly smaller lambda values in the oxygenated blood than in deoxygenated blood, whereas SF6, acetone and N2 were little dependent on SO2. An increase in lambda was found for ethane and a decrease for halothane with increasing pH in the blood. The other gases were not significantly influenced by pH. In spite of these experimental findings, regional difference of either SO2 or pH in the lung did not exert important influence on the inert gas exchange or on the predicted VA/Q distribution. In conclusion, blood-gas partition coefficients of some inert gases are consistently altered by SO2 and pH, but their possible effects on inert gas exchange seem to be negligible. PMID:1965757

  20. Impact of Perioperative Synthetic Insulation Measures on Vital Sign,Blood Gas Analysis Re-sults,Blood Coagulation and Other Indexes in Puerperas with Hemorrhagic Shock During Cesar-ean Section%围术期综合保温措施对失血性休克产妇剖宫产手术中生命体征、血气分析及凝血功能等指标的影响

    Institute of Scientific and Technical Information of China (English)

    罗春水

    2014-01-01

    To assess the impact of perioperative synthetic insulation measures on the result of operation for puerperas with hemorrhagic shock .[Methods] Totally 200 patients were randomly divided into two groups .The control group was treated with conventional surgical method ,while the observation group was given perioperative synthetic insulation measures .Blood pressure ,heart rate ,respiration ,nasopharyngeal temperature ,blood coagulation ,blood gas analysis results ,hematocrit ,blood lactic acid value ,the incidence of postoperative shivering ,the rate of successful rescue and hospital stay were compared between two groups .[Results] The vital signs of patients in observation group were all better than those of patients in control group ( P <0 .05) .The incidence of postoperative shivering in observation group was 16 .00% ,which was lower than that in control group(37 .00% ) ,and the rate of successful rescue was 93% ,which was higher than that in control group(76 .00% ) .The length of stay in observation group were (10 .20 ± 5 .10)d ,which was shorter than that in control group .There were significant differences( P<0 .05) .[Conclusion]Perioperative synthetic insulation measures can reduce the incidence of maternal complications of puerpera with hemorrhagic shock , improve the success rate of operation rescue ,help the recovery of patients and shorten the hospital stay .%【目的】评估围手术期综合保温措施对失血性休克产妇剖宫产手术中生命体征、血气分析及凝血功能等指标的影响。【方法】将200例失血性休克拟行剖宫产产妇随机分为两组,对照组围术期按照常规进行护理,观察组围手术期采用综合保温措施,比较两组患者的血压、心率、呼吸、鼻咽部体温、凝血功能、血气分析结果、红细胞压积、血乳酸值及术后寒战发生率、抢救成功率和住院时间。【结果】观察组患者的各项生命体征均优于对照组( P <0.05);患

  1. Stress Analysis of Shallow Sea Gas Pipelines

    Directory of Open Access Journals (Sweden)

    Xiaonan Wu

    2014-01-01

    Full Text Available Shallow sea gas pipelines usually operate in complicated and changeable regional environments and can generate corresponding stresses and displacement under the influence of internal pressures, earthquakes, waves and other loadings. An unevenly distributed stress will lead to shallow sea gas pipeline failure easily. In order to ensure the safety of pipeline, it is necessary to research the stress conditions of the shallow sea gas pipeline and check whether it can meet the safety requirements or not. In this study, we analyze the stress conditions of shallow sea gas pipelines of two laying modes in XX areas using stress analysis software CAESAR II, discuss the loading conditions under the operating condition and determine the position of the key point where pipeline damage is most likely to happen, the bend pipe. The comprehensive experiments show that underground method more secure than the sea-bed method, it greatly improves the reliability of the shallow sea pipeline running. Our research provides a theoretical basis for the construction of shallow sea gas pipelines.

  2. Natural gas product and strategic analysis

    International Nuclear Information System (INIS)

    Product and strategic analysis at the Department of Energy (DOE)/Morgantown Energy Technology Center (METC) crosscuts all sectors of the natural gas industry. This includes the supply, transportation, and end-use sectors of the natural-gas market. Projects in the Natural Gas Resource and Extraction supply program have been integrated into a new product focus. Product development facilitates commercialization and technology transfer through DOE/industry cost-shared research, development, and demonstration (RD ampersand D). Four products under the Resource and Extraction program include Resource and Reserves; Low Permeability Formations; Drilling, Completion, and Stimulation: and Natural Gas Upgrading. Engineering process analyses have been performed for the Slant Hole Completion Test project. These analyses focused on evaluation of horizontal-well recovery potential and applications of slant-hole technology. Figures 2 and 3 depict slant-well in situ stress conditions and hydraulic fracture configurations. Figure 4 presents Paludal Formation coal-gas production curves used to optimize the hydraulic fracture design for the slant well. Economic analyses have utilized data generated from vertical test wells to evaluate the profitability of horizontal technology for low-permeability formations in Yuma County, Colorado, and Maverick County, Texas

  3. Gene expression analysis in human breast cancer associated blood vessels.

    Directory of Open Access Journals (Sweden)

    Dylan T Jones

    Full Text Available Angiogenesis is essential for solid tumour growth, whilst the molecular profiles of tumour blood vessels have been reported to be different between cancer types. Although presently available anti-angiogenic strategies are providing some promise for the treatment of some cancers it is perhaps not surprisingly that, none of the anti-angiogenic agents available work on all tumours. Thus, the discovery of novel anti-angiogenic targets, relevant to individual cancer types, is required. Using Affymetrix microarray analysis of laser-captured, CD31-positive blood vessels we have identified 63 genes that are upregulated significantly (5-72 fold in angiogenic blood vessels associated with human invasive ductal carcinoma (IDC of the breast as compared with blood vessels in normal human breast. We tested the angiogenic capacity of a subset of these genes. Genes were selected based on either their known cellular functions, their enriched expression in endothelial cells and/or their sensitivity to anti-VEGF treatment; all features implicating their involvement in angiogenesis. For example, RRM2, a ribonucleotide reductase involved in DNA synthesis, was upregulated 32-fold in IDC-associated blood vessels; ATF1, a nuclear activating transcription factor involved in cellular growth and survival was upregulated 23-fold in IDC-associated blood vessels and HEX-B, a hexosaminidase involved in the breakdown of GM2 gangliosides, was upregulated 8-fold in IDC-associated blood vessels. Furthermore, in silico analysis confirmed that AFT1 and HEX-B also were enriched in endothelial cells when compared with non-endothelial cells. None of these genes have been reported previously to be involved in neovascularisation. However, our data establish that siRNA depletion of Rrm2, Atf1 or Hex-B had significant anti-angiogenic effects in VEGF-stimulated ex vivo mouse aortic ring assays. Overall, our results provide proof-of-principle that our approach can identify a cohort of

  4. Effect of saline infusion for the maintenance of blood volume on pulmonary gas exchange during temporary abdominal aortic occlusion

    Directory of Open Access Journals (Sweden)

    F.F. Amorim

    2007-03-01

    Full Text Available We analyzed the effects of saline infusion for the maintenance of blood volume on pulmonary gas exchange in ischemia-reperfusion syndrome during temporary abdominal aortic occlusion in dogs. We studied 20 adult mongrel dogs weighing 12 to 23 kg divided into two groups: ischemia-reperfusion group (IRG, N = 10 and IRG submitted to saline infusion for the maintenance of mean pulmonary arterial wedge pressure between 10 and 20 mmHg (IRG-SS, N = 10. All animals were anesthetized and maintained on spontaneous ventilation. After obtaining baseline measurements, occlusion of the supraceliac aorta was performed by the inflation of a Fogarty catheter. After 60 min of ischemia, the balloon was deflated and the animals were observed for another 60 min of reperfusion. The measurements were made at 10 and 45 min of ischemia, and 5, 30, and 60 min of reperfusion. Pulmonary gas exchange was impaired in the IRG-SS group as demonstrated by the increase of the alveolar-arterial oxygen difference (21 ± 14 in IRG-SS vs 11 ± 8 in IRG after 60 min of reperfusion, P = 0.004 in IRG-SS in relation to baseline values and the decrease of oxygen partial pressure in arterial blood (58 ± 15 in IRG-SS vs 76 ± 15 in IRG after 60 min of reperfusion, P = 0.001 in IRG-SS in relation to baseline values, which was correlated with the highest degree of pulmonary edema in morphometric analysis (0.16 ± 0.06 in IRG-SS vs 0.09 ± 0.04 in IRG, P = 0.03 between groups. There was also a smaller ventilatory compensation of metabolic acidosis after the reperfusion. We conclude that infusion of normal saline worsened the gas exchange induced by pulmonary reperfusion injury in this experimental model.

  5. Effect of caffeine citrate on the blood gas indexes in newborns with apnea

    Institute of Scientific and Technical Information of China (English)

    Chun-Yan Wu; Xiao-Jiao Wang; Yuan-Yuan Wang

    2015-01-01

    Objective:To explore the effect of caffeine citrate on the blood gas indexes in newborns with apnea.Methods: A total of 108 primary premature infants diagnosed with apnea were included in the study and randomized into the caffeine citrate treatment group and the aminophylline control group with 54 cases in each group. The apnea episode duration 72 h after medication, and the blood gas before medication and 24, 48, 72 h after medication between the two groups were compared.Results: The apnea episode duration 24, 48, 72 h after medication in the treatment group was significantly shorter than that in the control group. PaO2 24, 48, 72 h after medication in the treatment group was significantly higher than that in the control group, while PaCO2 was significantly reduced when compared with the control group.Conclusions:Caffeine citrate has achieved a significantly clinical effect in the treatment of newborn apnea, as a new therapeutic drug, is worthy of being widely recommended in the clinic.

  6. Linearity analysis and comparison study on the epoc® point-of-care blood analysis system in cardiopulmonary bypass patients

    Science.gov (United States)

    Chen, Jianing; Gorman, Monique; O’Reilly, Bill; Chen, Yu

    2016-01-01

    The epoc® blood analysis system (Epocal Inc., Ottawa, Ontario, Canada) is a newly developed in vitro diagnostic hand-held analyzer for testing whole blood samples at point-of-care, which provides blood gas, electrolytes, ionized calcium, glucose, lactate, and hematocrit/calculated hemoglobin rapidly. The analytical performance of the epoc® system was evaluated in a tertiary hospital, see related research article “Analytical evaluation of the epoc® point-of-care blood analysis system in cardiopulmonary bypass patients” [1]. Data presented are the linearity analysis for 9 parameters and the comparison study in 40 cardiopulmonary bypass patients on 3 epoc® meters, Instrumentation Laboratory GEM4000, Abbott iSTAT, Nova CCX, and Roche Accu-Chek Inform II and Performa glucose meters. PMID:26937460

  7. Linearity analysis and comparison study on the epoc(®) point-of-care blood analysis system in cardiopulmonary bypass patients.

    Science.gov (United States)

    Chen, Jianing; Gorman, Monique; O'Reilly, Bill; Chen, Yu

    2016-03-01

    The epoc(®) blood analysis system (Epocal Inc., Ottawa, Ontario, Canada) is a newly developed in vitro diagnostic hand-held analyzer for testing whole blood samples at point-of-care, which provides blood gas, electrolytes, ionized calcium, glucose, lactate, and hematocrit/calculated hemoglobin rapidly. The analytical performance of the epoc(®) system was evaluated in a tertiary hospital, see related research article "Analytical evaluation of the epoc(®) point-of-care blood analysis system in cardiopulmonary bypass patients" [1]. Data presented are the linearity analysis for 9 parameters and the comparison study in 40 cardiopulmonary bypass patients on 3 epoc(®) meters, Instrumentation Laboratory GEM4000, Abbott iSTAT, Nova CCX, and Roche Accu-Chek Inform II and Performa glucose meters. PMID:26937460

  8. Linearity analysis and comparison study on the epoc® point-of-care blood analysis system in cardiopulmonary bypass patients

    Directory of Open Access Journals (Sweden)

    Jianing Chen

    2016-03-01

    Full Text Available The epoc® blood analysis system (Epocal Inc., Ottawa, Ontario, Canada is a newly developed in vitro diagnostic hand-held analyzer for testing whole blood samples at point-of-care, which provides blood gas, electrolytes, ionized calcium, glucose, lactate, and hematocrit/calculated hemoglobin rapidly. The analytical performance of the epoc® system was evaluated in a tertiary hospital, see related research article “Analytical evaluation of the epoc® point-of-care blood analysis system in cardiopulmonary bypass patients” [1]. Data presented are the linearity analysis for 9 parameters and the comparison study in 40 cardiopulmonary bypass patients on 3 epoc® meters, Instrumentation Laboratory GEM4000, Abbott iSTAT, Nova CCX, and Roche Accu-Chek Inform II and Performa glucose meters.

  9. 肺表面活性物质联合布地奈德对急性呼吸窘迫综合征极低出生体质量儿血气分析的影响%Effect of using pulmonary surfactant mixed with budesonide on blood gas analysis in very low birth weight premature with acute respiratory distress syndrome

    Institute of Scientific and Technical Information of China (English)

    魏红娟; 任秀伟; 刘俊影; 王会悦; 宋思佳

    2015-01-01

    Objective:To explore the influence of Blood gas analysis in very low birth weight premature with acute respiratory distress syndrome ( ARDS) after using pulmonary surfactant(PS) mixed with budesonide,and evaluate the therapeutic effect of combination. Methods:Twenty-eight premature infants with gestational age <33weeks,birth weight <1500 g,whose ARDS occurred within 6 hours after birth were andomly assigned into the experimental group and treatment group in Daqing Oil Field Gneral Hspital from December 2013 to November 2014,Experimental group using lung pulmonary surfactant 100mg/kg +budesonide 0.25mg/kg (male 8 cases, female 6 ca-ses) drip endotracheal cooperate with mechanical ventilation.The treatment group used alone lung pulmonary surfactant ( male 9 case,fe-male 5 cases) , 100mg/kg endotracheal drip with mechanical ventilation, drug drip time within 60 minutes after birth.Track two groups of Blood gas analysis.Results:The experimental group a newborn and the treatment group 1, 6, 12, 24 h blood gas analysis of pH value, oxygen partial pressure(Pa O2), CO2 partial pressure (Pa CO2), alveolar artery oxygen partial pressure difference (AaDO2) were sig-nificant differences (P <0.05).Conclusion:using PS joint budesonide on ARDS could improve blood gas analysis, improve the diffi-culty in breathing, shorten the time of oxygen, might be advantageous to the premature stop oxygen as soon as possible, reduce the lung injury, relieve the patient's medical expenses, worth clinical promotion.%目的:探讨肺表面活性物质( PS)联合布地奈德对急性呼吸窘迫综合征( ARDS)极低出生体质量儿血气分析的影响,并评价用药的治疗效果。方法:2013年12月~2014年11月在大庆油田总医院新生儿科收治的的胎龄<33周、出生体质量<1500 g、出生6小时内发生ARDS的早产儿28例,随机分为实验组和治疗组,实验组使用肺表面活性物质(固尔苏)100mg/kg+布地奈德0.25mg

  10. Stability of blood gases when refrigerated

    OpenAIRE

    Ferreira, J.; S. Silva; Rodrigues, P.; Abreu, M.; Maia, J.; Carvalho, D; Carvalho, L.

    2012-01-01

    Background: Blood gas analysis is a widely used procedure. In clinical practice, the physicians may not always have a blood gas analyzer in their proximity. Not infrequently, blood gas samples are stored in a fridge or on ice and read retrospectively. Continued anaerobic and aerobic metabolism in the blood may alter blood gases in the interval between drawing arterial blood and its analysis, which may cause a fall in the PaO2 and pH and a rise in the PaCO2. Methods: Two s...

  11. Detrended fluctuation analysis of a systolic blood pressure control loop

    Energy Technology Data Exchange (ETDEWEB)

    Galhardo, C E C; Penna, T J P; Argollo de Menezes, M [Instituto de Fisica, Universidade Federal Fluminense, Av. Litoranea, s/n, 24210-340, Niteroi, RJ (Brazil); Soares, P P S [Instituto Biomedico, Universidade Federal Fluminense, R. Prof. Hernani Melo n. 101, 24210-130, Niteroi, RJ (Brazil)], E-mail: marcio@mail.if.uff.br

    2009-10-15

    We use detrended fluctuation analysis (DFA) to study the dynamics of blood pressure oscillations and its feedback control in rats by analyzing systolic pressure time series before and after a surgical procedure that interrupts its control loop. We found, for each situation, a crossover between two scaling regions characterized by exponents that reflect the nature of the feedback control and its range of operation. In addition, we found evidence of adaptation in the dynamics of blood pressure regulation a few days after surgical disruption of its main feedback circuit. Based on the paradigm of antagonistic, bipartite (vagal and sympathetic) action of the central nerve system, we propose a simple model for pressure homeostasis as the balance between two nonlinear opposing forces, successfully reproducing the crossover observed in the DFA of actual pressure signals.

  12. Detrended Fluctuation Analysis of Systolic Blood Pressure Control Loop

    CERN Document Server

    Galhardo, C E C; de Menezes, M Argollo; Soares, P P S

    2009-01-01

    We use detrended fluctuation analysis (DFA) to study the dynamics of blood pressure oscillations and its feedback control in rats by analyzing systolic pressure time series before and after a surgical procedure that interrupts its control loop. We found, for each situation, a crossover between two scaling regions characterized by exponents that reflect the nature of the feedback control and its range of operation. In addition, we found evidences of adaptation in the dynamics of blood pressure regulation a few days after surgical disruption of its main feedback circuit. Based on the paradigm of antagonistic, bipartite (vagal and sympathetic) action of the central nerve system, we propose a simple model for pressure homeostasis as the balance between two nonlinear opposing forces, successfully reproducing the crossover observed in the DFA of actual pressure signals.

  13. Laser speckle imaging of rat retinal blood flow with hybrid temporal and spatial analysis method

    Science.gov (United States)

    Cheng, Haiying; Yan, Yumei; Duong, Timothy Q.

    2009-02-01

    Noninvasive monitoring of blood flow in retinal circulation will reveal the progression and treatment of ocular disorders, such as diabetic retinopathy, age-related macular degeneration and glaucoma. A non-invasive and direct BF measurement technique with high spatial-temporal resolution is needed for retinal imaging. Laser speckle imaging (LSI) is such a method. Currently, there are two analysis methods for LSI: spatial statistics LSI (SS-LSI) and temporal statistical LSI (TS-LSI). Comparing these two analysis methods, SS-LSI has higher signal to noise ratio (SNR) and TSLSI is less susceptible to artifacts from stationary speckle. We proposed a hybrid temporal and spatial analysis method (HTS-LSI) to measure the retinal blood flow. Gas challenge experiment was performed and images were analyzed by HTS-LSI. Results showed that HTS-LSI can not only remove the stationary speckle but also increase the SNR. Under 100% O2, retinal BF decreased by 20-30%. This was consistent with the results observed with laser Doppler technique. As retinal blood flow is a critical physiological parameter and its perturbation has been implicated in the early stages of many retinal diseases, HTS-LSI will be an efficient method in early detection of retina diseases.

  14. Environmental analysis for pipeline gas demonstration plants

    Energy Technology Data Exchange (ETDEWEB)

    Stinton, L.H.

    1978-09-01

    The Department of Energy (DOE) has implemented programs for encouraging the development and commercialization of coal-related technologies, which include coal gasification demonstration-scale activities. In support of commercialization activities the Environmental Analysis for Pipeline Gas Demonstration Plants has been prepared as a reference document to be used in evaluating potential environmental and socioeconomic effects from construction and operation of site- and process-specific projects. Effluents and associated impacts are identified for six coal gasification processes at three contrasting settings. In general, impacts from construction of a high-Btu gas demonstration plant are similar to those caused by the construction of any chemical plant of similar size. The operation of a high-Btu gas demonstration plant, however, has several unique aspects that differentiate it from other chemical plants. Offsite development (surface mining) and disposal of large quantities of waste solids constitute important sources of potential impact. In addition, air emissions require monitoring for trace metals, polycyclic aromatic hydrocarbons, phenols, and other emissions. Potential biological impacts from long-term exposure to these emissions are unknown, and additional research and data analysis may be necessary to determine such effects. Possible effects of pollutants on vegetation and human populations are discussed. The occurrence of chemical contaminants in liquid effluents and the bioaccumulation of these contaminants in aquatic organisms may lead to adverse ecological impact. Socioeconomic impacts are similar to those from a chemical plant of equivalent size and are summarized and contrasted for the three surrogate sites.

  15. Peripheral blood smear image analysis: A comprehensive review

    Directory of Open Access Journals (Sweden)

    Emad A Mohammed

    2014-01-01

    Full Text Available Peripheral blood smear image examination is a part of the routine work of every laboratory. The manual examination of these images is tedious, time-consuming and suffers from interobserver variation. This has motivated researchers to develop different algorithms and methods to automate peripheral blood smear image analysis. Image analysis itself consists of a sequence of steps consisting of image segmentation, features extraction and selection and pattern classification. The image segmentation step addresses the problem of extraction of the object or region of interest from the complicated peripheral blood smear image. Support vector machine (SVM and artificial neural networks (ANNs are two common approaches to image segmentation. Features extraction and selection aims to derive descriptive characteristics of the extracted object, which are similar within the same object class and different between different objects. This will facilitate the last step of the image analysis process: pattern classification. The goal of pattern classification is to assign a class to the selected features from a group of known classes. There are two types of classifier learning algorithms: supervised and unsupervised. Supervised learning algorithms predict the class of the object under test using training data of known classes. The training data have a predefined label for every class and the learning algorithm can utilize this data to predict the class of a test object. Unsupervised learning algorithms use unlabeled training data and divide them into groups using similarity measurements. Unsupervised learning algorithms predict the group to which a new test object belong to, based on the training data without giving an explicit class to that object. ANN, SVM, decision tree and K-nearest neighbor are possible approaches to classification algorithms. Increased discrimination may be obtained by combining several classifiers together.

  16. Determination of dimethyl trisulfide in rabbit blood using stir bar sorptive extraction gas chromatography-mass spectrometry.

    Science.gov (United States)

    Manandhar, Erica; Maslamani, Nujud; Petrikovics, Ilona; Rockwood, Gary A; Logue, Brian A

    2016-08-26

    Cyanide poisoning by accidental or intentional exposure poses a severe health risk. The current Food and Drug Administration approved antidotes for cyanide poisoning can be effective, but each suffers from specific major limitations concerning large effective dosage, delayed onset of action, or dependence on enzymes generally confined to specific organs. Dimethyl trisulfide (DMTS), a sulfur donor that detoxifies cyanide by converting it into thiocyanate (a relatively nontoxic cyanide metabolite), is a promising next generation cyanide antidote. Although a validated analytical method to analyze DMTS from any matrix is not currently available, one will be vital for the approval of DMTS as a therapeutic agent against cyanide poisoning. Hence, a stir bar sorptive extraction (SBSE) gas chromatography - mass spectrometry (GC-MS) method was developed and validated for the analysis of DMTS from rabbit whole blood. Following acid denaturation of blood, DMTS was extracted into a polydimethylsiloxane-coated stir bar. The DMTS was then thermally desorbed from the stir bar and analyzed by GC-MS. The limit of detection of DMTS using this method was 0.06μM with dynamic range from 0.5-100μM. For quality control standards, the precision, as measured by percent relative standard deviation, was below 10%, and the accuracy was within 15% of the nominal concentration. The method described here will allow further investigations of DMTS as a promising antidote for cyanide poisoning. PMID:27477518

  17. Method Development and Validation for Determining 1,3-Butadiene in Human Blood by Gas Chromatography-Mass Spectrometry and Head-Space Gas Chromatography%Method Development and Validation for Determining1,3-Butadiene in Human Blood by Gas Chromatography-Mass Spectrometry and Head-Space Gas Chromatography

    Institute of Scientific and Technical Information of China (English)

    ZHANG Su-jing; SHEN Bao-hua; ZHUO Xian-yi

    2013-01-01

    To develop a simple,validated method for identifying and quantifying 1,3-butadiene (BD) in human blood by gas chromatography-mass spectrometry (GC-MS) and head-space gas chromatography (HS-GC).BD was identified by GC-MS and HS-GC,and quantified by HS-GC.The method showed that BD had a good linearity from 50 to 500 μg/mL (r>0.99).The limits of detection and quantification were 10 μg/mL and 50 μg/mL,respectively.Both the intra-day precision and inter-day precision were <6.08%,and the accuracy was 96.98%-103.81%.The method was applied to an actual case,and the concentration of BD in the case was 242 μg/mL in human blood.This simple method is found to be useful for the routine forensic analysis of acute exposure to BD.

  18. Comparative Study of Unarmed and CPR Machine for Cardiopulmonary Resuscitation on Blood Gas Analysis%徒手和心肺复苏机用于心肺复苏对血气分析的影响对比研究

    Institute of Scientific and Technical Information of China (English)

    葛志文; 涂久生

    2015-01-01

    目的:对比探究对呼吸心脏骤停患者进行徒手救助和心肺复苏机施救两种急救方法对血气分析的影响和临床的效果。方法将我院收治的90例心脏骤停急救患者进行分组,其中对照组采用徒手救助使其心肺复苏,而观察组则采用心肺复苏机进行患者的急救治疗,对比两组患者在心肺复苏后5 min、15 min以及30 min时的动脉血气指标结果,探究两种急救方式的临床效果。结果两组接受相应治疗后观察组有效率达31.1%高于对照组,而在5 min时两组在血气指标无差异,在15 min和30 min时,观察组的PaO2和SaO2两项指标相比较对照组有很大提高,而PaCO2出现下降(P<0.05)。结论采用心肺复苏机进行该病患者的急救治疗,能够提高患者的心肺脑供血供氧水平,增加患者的心输出量,增加了治疗的有效率,保证患者的生命安全。%Objective To compare the exploration of respiratory cardiac arrest patients with clinical impact and effectiveness of unarmed aid and CPR machine emergency rescue of two methods of blood gas analysis. Methods 90 cases in our hospital cardiac arrest emergency patient group,which controls the use of unarmed CPR rescue it,and the observation group is using CPR machine for first aid treatment of patients,compared two groups of patients in cardiopulmonary resuscitation 5 min,15 min and 30 min,arterial blood gas results,explore the clinical effects of two emergency mode. Results The two groups receive appropriate treatment observation group was significantly higher effective rate of 31.1%,while in 5min two groups showed no difference in the flesh,at 15 and 30 min time, PaO2 and SaO2 two indicators of the observation group phase comparison of the control group has greatly improved,while PaCO2 decline(P< 0.05). Conclusion CPR machine first aid treatment of the disease patients can improve heart and lung patients with brain blood oxygen levels

  19. Systemic Metabolomic Changes in Blood Samples of Lung Cancer Patients Identified by Gas Chromatography Time-of-Flight Mass Spectrometry

    OpenAIRE

    Suzanne Miyamoto; Taylor, Sandra L.; Barupal, Dinesh K; Ayumu Taguchi; Gert Wohlgemuth; Wikoff, William R.; Yoneda, Ken Y.; Gandara, David R.; Samir M. Hanash; Kyoungmi Kim; Oliver Fiehn

    2015-01-01

    Lung cancer is a leading cause of cancer deaths worldwide. Metabolic alterations in tumor cells coupled with systemic indicators of the host response to tumor development have the potential to yield blood profiles with clinical utility for diagnosis and monitoring of treatment. We report results from two separate studies using gas chromatography time-of-flight mass spectrometry (GC-TOF MS) to profile metabolites in human blood samples that significantly differ from non-small cell lung cancer ...

  20. TRU Drum Headspace Gas Analysis System

    International Nuclear Information System (INIS)

    The Savannah River Site (SRS) has approximately 10,000 Transuranic (TRU) waste drums whose final disposition is the Waste Isolation Pilot Plant (WIPP) in Carlsbad, New Mexico. Each drum, prior to shipment to WIPP, must be inspected and tested to certify that is meets the WIPP requirements for acceptance. One, of many requirements, is the analysis of the TRU drum vapor space for hydrogen, methane, and volatile organic compounds (VOCs). The DOE Carlsbad Area Office has published two documents specifying the analytical methodologies and the quality assurance requirements for analyzing TRU drum vapor space.The Savannah River Technology Center (SRTC) was contracted by the Solid Waste Division of SRS to specify, assemble, and test a system that would satisfy the WIPP requirements for drum headspace gas analysis. Since no single vendor supplies a complete system, analytical instrumentation and supporting components were integrated into a configuration that performed that required analyses. This required both software and hardware design and modifications. The major goal of the design team was to integrate commercially available instrumentation and equipment into a seamless production process. The final output of the process is an analytical report formatted to the specifications outlined in the WIPP Quality Assurance Program Plan (QAPP). SRTC has assembled the necessary analytical instrumentation and installed it in a mobile trailer to perform the TRU drum vapor space analyses. This mobile trailer had previously housed instrumentation for reactor tank inspections. As a cost savings it was decided to renovate and install the instrumentation in this trailer to eliminate the need of building or modifying permanent structures. This also allows for portability to meet future analytical needs on or off site.This task was divided into three sub tasks: headspace gas sampling, gas analysis and system component integration, and sample canister cleaning. The following sections

  1. Influence of nursing intervention on vital signs and blood gas analysis indexes of AECOPD patients complicated with respiratory failure received non invasive ventilation treatment%护理干预对无创通气治疗 AECOPD 合并呼吸衰竭病人生命体征及血气分析指标的影响

    Institute of Scientific and Technical Information of China (English)

    汪晓艳

    2015-01-01

    [目的]探讨护理干预对无创通气治疗慢性阻塞性肺疾病急性加重期(AECOPD)合并呼吸衰竭病人生命体征及血气分析指标的影响。[方法]选择合肥市第三人民医院呼吸内科2010年10月—2012年2月收治的应用无创通气治疗 AECOPD 合并呼吸衰竭病人37例,在无创通气前、通气中进行有效的护理干预,观察通气前后心率、RR、pH、血二氧化碳分压(PaCO 2)、血氧分压(PaO 2)、血氧饱和度(SpO 2)的变化。[结果]通过有效的护理干预措施,通气治疗后的心率、RR、pH、PaCO 2、PaO 2、SpO 2较通气前有明显改善,差异有统计学意义(P <0.01)。[结论]对于 AECOPD 合并呼吸衰竭病人应用无创通气治疗时护理人员采取适时的护理干预,可显著提高治疗效果。%Objective:To probe into the influence of nursing intervention on vital signs and blood gas analysis in-dexes of patients with chronic obstructive pulmonary disease with acute exacerbation (AECOPD)complicated with respiratory failure received non invasive ventilation treatment Methods:A total of 37 cases of AECOPD patients complicated with respiratory failure were selected who were treated with noninvasive ventilation in de-partment of respiratory medicine in the third people’s hospital in hefei city from October 2010 to February 2012.They received the effective nursing intervention before noninvasive ventilation and during ventilation and to observe the change of heart rate,RR,pH,blood CO 2 partial pressure(PaCO 2 ),blood oxygen partial pressure (PaO 2 ),blood oxygen saturation (SpO 2 )before and after the ventilation.Results:Through effective nursing in-terventions,the heart rate,RR,pH,PaCO 2 ,PaO 2 ,SpO 2 were improved significantly after ventilation treatment, and the difference was statistically significant (P <0.01 ).Conclusion:For the AECOPD patients complicated with respiratory failure receiving non invasive ventilation,the timely nursing intervention can

  2. Geochemistry and Geologic Analysis in Shale Gas Play

    Institute of Scientific and Technical Information of China (English)

    Wenwu Xia; Mike D. Burnaman; John Shelton

    2009-01-01

    The understanding from the conventional geochemistry and geology analysis is very different when trying to apply them to shale gas plays. This paper is a summary for U.S. shale gas plays on geochemistry and geologic analysis application, and real field data from active U.S. shale gas plays is used in the discussion of different concepts.

  3. Portable real time analysis system for regional cerebral blood flow

    International Nuclear Information System (INIS)

    A very portable, regional cerebral blood flow (rCBF) analysis instrument system suitable for use in the operating theater during surgery is under development. Cadmium telluride (CdTe) solid state radiation detectors, an 8086 based data acquisition and communications module and a DEC Microvax computer are used so that the instrument is very compact, yet has the computational power to provide real time data analysis in the clinical environment. The instrument is currently being used at Bowman Gray School of Medicine to study rCBF during cardiopulmonary bypass surgery (CPB). Preliminary studies indicate that monitoring rCBF during this surgical procedure may provide insights into the mechanism that causes a significant fraction of these patients to suffer post operative neuropsychological deficit

  4. Portable real time analysis system for regional cerebral blood flow

    Energy Technology Data Exchange (ETDEWEB)

    Tiernan, T.; Entine, G.; Stump, D.A.; Prough, D.S.

    1988-02-01

    A very portable, regional cerebral blood flow (rCBF) analysis instrument system suitable for use in the operating theater during surgery is under development. Cadmium telluride (CdTe) solid state radiation detectors, an 8086 based data acquisition and communications module and a DEC Microvax computer are used so that the instrument is very compact, yet has the computational power to provide real time data analysis in the clinical environment. The instrument is currently being used at Bowman Gray School of Medicine to study rCBF during cardiopulmonary bypass surgery (CPB). Preliminary studies indicate that monitoring rCBF during this surgical procedure may provide insights into the mechanism that causes a significant fraction of these patients to suffer post operative neuropsychological deficit.

  5. Whole blood donor deferral analysis at Genera l hospital blood bank – A retrospective study.

    Directory of Open Access Journals (Sweden)

    Hinal Gajjar

    2014-07-01

    Full Text Available Background: A blood transfusion is a life saving procedure in many instances and it requir es an adequate supply of safe blood. The most important is the selection of blood donors by donor selection criteria. A large number of blood donors are deferred from donating blood for several reasons either temporarily or permanently. A shortage of safe blood donor is frequent and it is important to understand the causes of deferral of potential donors. Aims: 1. Primary objective of this study was to record and document the current rate and reasons for donor deferred in our blood bank. 2. Apply relevant findings to modify recruitment strategy for blood donors. Materials and methods: Data for WBD presenting for blood donation in a blood bank V S General Hospital and outdoor camps over two and half years from January 2011 to June 2013 were analysed retrospectively. National Guidelines were used for selection & deferral of WBD. Results: 3836 (11.16% WBD were deferred out of 34373 registered donors during the study period. Donor deferrals were tabulated into temporary and permanent reasons. Temporary deferrals were 3113 (81.15% and permanent deferrals were 723 (18.85%. The most common reasons were low haemoglobin (48.33%, high blood pressure (11.94%, underweight donors (7.95% and history of medication use (6.13% among total deferral donors. Majority of donors (47.16% deferred were between 18 -30 years. Females were found to have higher deferral rate (25.48% than males (10.76%. Discussion and conclusion: A deferral study in blood donors may shed light on the health status of general population which may affect the present and future blood supply. It is important to provide donors with a clear message on their deferral status so that most of temporary deferral donors will return for donation in future.

  6. FTIR gas chromatographic analysis of perfumes

    Science.gov (United States)

    Diederich, H.; Stout, Phillip J.; Hill, Stephen L.; Krishnan, K.

    1992-03-01

    Perfumes, natural or synthetic, are complex mixtures consisting of numerous components. Gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) techniques have been extensively utilized for the analysis of perfumes and essential oils. A limited number of perfume samples have also been analyzed by FT-IR gas chromatographic (GC-FTIR) techniques. Most of the latter studies have been performed using the conventional light pipe (LP) based GC-FTIR systems. In recent years, cold-trapping (in a matrix or neat) GC-FTIR systems have become available. The cold-trapping systems are capable of sub-nanogram sensitivities. In this paper, comparison data between the LP and the neat cold-trapping GC- FTIR systems is presented. The neat cold-trapping interface is known as Tracer. The results of GC-FTIR analysis of some commercial perfumes is also presented. For comparison of LP and Tracer GC-FTIR systems, a reference (synthetic) mixture containing 16 major and numerous minor constituents was used. The components of the mixture are the compounds commonly encountered in commercial perfumes. The GC-FTIR spectra of the reference mixture was obtained under identical chromatographic conditions from an LP and a Tracer system. A comparison of the two sets of data thus generated do indeed show the enhanced sensitivity level of the Tracer system. The comparison also shows that some of the major components detected by the Tracer system were absent from the LP data. Closer examination reveals that these compounds undergo thermal decomposition on contact with the hot gold surface that is part of the LP system. GC-FTIR data were obtained for three commercial perfume samples. The major components of these samples could easily be identified by spectra search against a digitized spectral library created using the Tracer data from the reference mixture.

  7. Simple gas chromatographic method for furfural analysis.

    Science.gov (United States)

    Gaspar, Elvira M S M; Lopes, João F

    2009-04-01

    A new, simple, gas chromatographic method was developed for the direct analysis of 5-hydroxymethylfurfural (5-HMF), 2-furfural (2-F) and 5-methylfurfural (5-MF) in liquid and water soluble foods, using direct immersion SPME coupled to GC-FID and/or GC-TOF-MS. The fiber (DVB/CAR/PDMS) conditions were optimized: pH effect, temperature, adsorption and desorption times. The method is simple and accurate (RSDHMF; GC-TOF-MS: 0.3, 1.2 and 0.9 ngmL(-1) for 2-F, 5-MF and 5-HMF, respectively). It was applied to different commercial food matrices: honey, white, demerara, brown and yellow table sugars, and white and red balsamic vinegars. This one-step, sensitive and direct method for the analysis of furfurals will contribute to characterise and quantify their presence in the human diet. PMID:18976770

  8. Spatial Analysis of the Japanese Gas Industry

    OpenAIRE

    Akio Kusakabe; Jinhwan Oh

    2011-01-01

    This study analyzes gas prices, costs, and expenditures in Japan from a spatial perspective. The main findings are as follows: (1) Gas prices, costs, and expenditures exhibit spatially dependent patterns throughout Japan and are related to the service area locations of the gas distributors. (2) Regional conditions, including weather, production shipment, and availability and method of procuring domestic natural gas are the main determinants influencing gas prices and cost levels in Japan. The...

  9. Associations of methylmercury and inorganic mercury between human cord blood and maternal blood: A meta-analysis and its application

    International Nuclear Information System (INIS)

    Considering the different ability of placental transfer, an assessment of the cord:maternal blood ratio for both methylmercury (MeHg) and inorganic mercury (IHg) is needed especially for interpreting the low-level prenatal exposure. In this study, we conducted a Monte Carlo-based meta-analysis to comprehensively estimate that ratio for MeHg (RMeHg) and IHg (RIHg). The obtained values followed log-normal distributions, with a mean (standard deviation) of 1.89 (0.98) and 1.01 (0.55) for RMeHg and RIHg, respectively. We also estimated the percentage of MeHg in the blood by means of THg in cord and maternal blood using the RMeHg and RIHg, and obtained a value very close to the measured one (relative deviation, −0.4%). In conclusion, the fetus is exposed to approximately twice as much MeHg and to the same level of IHg as in maternal blood; the introduced model provides a rough but reasonable estimate of the percentage of MeHg in the blood. - Highlights: • The cord:maternal blood ratio for methylmerucry was obtained by meta-analyses. • The cord:maternal blood ratio for inorganic mercury was obtained by meta-analyses. • A new model to estimate the percentage of methylmercury in blood was introduced. - The cord:maternal blood ratio distributions and the approach to estimate MeHg percentage in the blood in this paper may provide a new perspective of interpreting prenatal mercury exposure

  10. Reliability of point-of-care hematocrit, blood gas, electrolyte, lactate and glucose measurement during cardiopulmonary bypass.

    NARCIS (Netherlands)

    Steinfelder-Visscher, J.; Weerwind, P.W.; Teerenstra, S.; Brouwer, M.H.J.

    2006-01-01

    BACKGROUND: Recently, the GEM Premier blood gas analyser was upgraded to the GEM Premier 3000. In addition to pH, pCO2, pO2, Na+, K+, Ca2+, and hematocrit measurement, glucose and lactate can be measured on the GEM Premier 3000. In this prospective clinical study, the analytical performance of the G

  11. Analysis of Flux of Gas Passing Circle Lacuna

    Institute of Scientific and Technical Information of China (English)

    ZHAO Shi-jun; SUN Ke-yu; YU Xiu-ping

    2002-01-01

    The rate of flow of the gas flowing through cirque chink often needs calculation in engineering. The characters of compressibility and thermodynamics have some effect on the gas flowing, so the analysis on the flow of gas is more complex than that of liquid. But under different conditions and different requirements of precision the analysis can be simplified suitably, then make the formulae given become simple subsequently. This paper analyzes various gas flux based on basic characters and motion laws of gas and the analysis is just applied in an engineering project.

  12. Residual gas analysis in ISX-A

    International Nuclear Information System (INIS)

    A computer-controlled mass analyzer was utilized to observe the residual gases in the ISX-A tokamak. This residual gas analysis (RGA) system enabled time resolved measurements of preselected m/e peak heights to be made during and after tokamak discharges. Routine mass scans were also made and displayed in the form of semilogarithmic plots of partial pressure (torr) versus m/e. Wall conditioning of the stainless steel torus consisted of hydrogen discharge cleaning and titanium gettering, which ultimately produced gage pressures on the order of 10-8 and 10-9 torr, respectively. The dominant plasma impurities, carbon and oxygen, were observed by the RGA as light hydrocarbons and water vapor. Entrapment of deuterium by the walls was investigated by monitoring the residual D2 content after the working gas was changed to H2. The effective nuclear charge (Z/sub eff/) was found to be proportional to the residual contaminants measured by the RGA immediately following a discharge

  13. Nondestructive fission gas release measurement and analysis

    Energy Technology Data Exchange (ETDEWEB)

    O' Leary, P.M.; Packard, D.R. (Siemens Nuclear Power Corp., Richland, WA (United States))

    1993-01-01

    Siemens Power Corporation (SPC) has performed reactor poolside gamma scanning measurements of fuel rods for fission gas release (FGR) detection for more than 10 yr. The measurement system has been previously described. Over the years, the data acquisition system, the method of spectrum analysis, and the means of reducing spectrum interference have been significantly improved. A personal computer (PC)-based multichannel analyzer (MCA) package is used to collect, display, and store high-resolution gamma-ray spectra measured in the fuel rod plenum. A PC spread sheet is used to fit the measured spectra and compute sample count rates after Compton background subtraction. A Zircaloy plenum spacer is often used to reduce positron annihilation interference that can arise from the INCONEL[sup [reg sign

  14. Investments in natural gas - an empirical analysis with emphasis on the shale gas revolution

    OpenAIRE

    Lorentzen, Pål Holmefjord

    2015-01-01

    The main objective in this thesis is to investigate how various factors are influencing investments in the US natural gas industry. The thesis puts a special emphasis on the “Shale Gas Revolution” that struck the US natural gas market in 2006/2007 and how it has affected investments in natural gas. The yearly growth rate in shale gas production from 2007-2013 was 31 %. The analysis is based on data from the period 1990-2013. The thesis gives an overview of the US natural gas market and its p...

  15. Methods for analysis of citrinin in human blood and urine.

    Science.gov (United States)

    Blaszkewicz, Meinolf; Muñoz, Katherine; Degen, Gisela H

    2013-06-01

    Citrinin (CIT), produced by several Penicillium, Aspergillus, and Monascus species, has been detected as contaminant in feeds, grains, and other food commodities. CIT can co-occur with ochratoxin A (OTA), a mycotoxin also known for its nephrotoxicity, and this raises concern regarding possible combined effects. But, in contrast to OTA, data on CIT contamination in foods for human consumption are scarce, and CIT biomonitoring has not been conducted so far due a lack of suitable methods for human specimen. Thus, it was the aim of the present study to develop sensitive methods for the analysis of CIT in human blood and urine to investigate human exposure. To this end, we assessed different methods of sample preparation and instrumental analysis for these matrices. Clean-up of blood plasma by protein precipitation followed by LC-MS/MS-based analysis allowed robust detection of CIT (LOD 0.07 ng/mL, LOQ 0.15 ng/mL). For urine, sample clean-up by an immunoaffinity column (CitriTest(®)) proved to be clearly superior to SPE with RP(18) material for subsequent analysis by LC-MS/MS. For CIT and its metabolite dihydrocitrinone (HO-CIT), the LOD and LOQ determined by external calibration curves in matrix were 0.02 and 0.05 ng/mL for CIT, and those for HO-CIT were 0.05 and 0.1 ng/mL urine. The newly developed method was applied in a small pilot study: CIT was present in all plasma samples from 8 German adults, at concentrations ranging from 0.11 to 0.26 ng/mL. The molar (nM) concentrations of CIT are similar to those measured for OTA in these samples as a result of dietary mycotoxin intake. CIT was detected in 8/10 urines (from 4 adults and 6 infants) in a range of 0.16-0.79 ng/mL, and HO-CIT was present in 5/10 samples at similar concentrations. Thus, CIT is excreted in urine as parent compound and also as metabolite. These first results in humans point to the need for further studies on CIT exposure. PMID:23354378

  16. Non-invasive pulmonary blood flow analysis and blood pressure mapping derived from 4D flow MRI

    Science.gov (United States)

    Delles, Michael; Rengier, Fabian; Azad, Yoo-Jin; Bodenstedt, Sebastian; von Tengg-Kobligk, Hendrik; Ley, Sebastian; Unterhinninghofen, Roland; Kauczor, Hans-Ulrich; Dillmann, Rüdiger

    2015-03-01

    In diagnostics and therapy control of cardiovascular diseases, detailed knowledge about the patient-specific behavior of blood flow and pressure can be essential. The only method capable of measuring complete time-resolved three-dimensional vector fields of the blood flow velocities is velocity-encoded magnetic resonance imaging (MRI), often denoted as 4D flow MRI. Furthermore, relative pressure maps can be computed from this data source, as presented by different groups in recent years. Hence, analysis of blood flow and pressure using 4D flow MRI can be a valuable technique in management of cardiovascular diseases. In order to perform these tasks, all necessary steps in the corresponding process chain can be carried out in our in-house developed software framework MEDIFRAME. In this article, we apply MEDIFRAME for a study of hemodynamics in the pulmonary arteries of five healthy volunteers. The study included measuring vector fields of blood flow velocities by phase-contrast MRI and subsequently computing relative blood pressure maps. We visualized blood flow by streamline depictions and computed characteristic values for the left and the right pulmonary artery (LPA and RPA). In all volunteers, we observed a lower amount of blood flow in the LPA compared to the RPA. Furthermore, we visualized blood pressure maps using volume rendering and generated graphs of pressure differences between the LPA, the RPA and the main pulmonary artery. In most volunteers, blood pressure was increased near to the bifurcation and in the proximal LPA, leading to higher average pressure values in the LPA compared to the RPA.

  17. Penile rehabilitation with a vacuum erectile device in an animal model is related to an antihypoxic mechanism:blood gas evidence

    Institute of Scientific and Technical Information of China (English)

    Hao-Cheng Lin; Wen-Li Yang; Jun-Lan Zhang; Yu-Tian Dai; Run Wang

    2013-01-01

    Our previous study showed that vacuum erectile device (VED) therapy has improved erectile function in rats with bilateral cavernous nerve crush (BCNC) injuries.This study was designed to explore the mechanism of VED in penile rehabilitation by analyzing cavernous oxygen saturation (S02) and to examine the effect of VED therapy on preventing penile shrinkage after BCNC.Thirty adult SpragueDawley rats were randomly assigned into three groups:group 1,sham surgery; group 2,BCNC; and group 3,BCNC+VED.Penile length and diameter were measured on a weekly basis.After 4 weeks of therapy,the penile blood was extracted by three methods for blood gas analysis (BGA):method 1,cavernous blood was aspirated at the flaccid state; method 2,cavernous blood was aspirated at the traction state; and method 3,cavernous blood was aspirated immediately after applying VED.SO2 values were tested by the blood gas analyzer.The results showed that VED therapy is effective in preventing penile shrinkage induced by BCNC (Penile shortening:BCNC group 1.9±1.1 mm; VED group 0.3±1.0 mm; P<0.01.Penile diameter reduction:BCNC group 0.28±0.14 mm; VED group 0.04±0.14 mm; P<0.0 1).The mean S02±s.d.values were increased by VED application (88.25%±4.94%) compared to the flaccid (76.53%±4.16%) or traction groups (78.93%±2.56%) (P<0.05).The calculated blood constructs in the corpus cavernosum right after VED application were 62% arterial and 38% venous blood.These findings suggest that VED therapy can effectively preserve penile size in rats with BCNC injury.The beneficial effect of VED therapy is related to antihypexia by increasing cavernous blood S02.

  18. PIXE analysis of chinese chicken-blood stone

    International Nuclear Information System (INIS)

    This paper reports the chemical compositions of chicken-blood stone Ji Xue Shi measured by Proton Induced X-ray Emission (PIXE). The experimental result show that for the red portion of chicken-blood stone, the concentration of Hg is as high as 20 wt%, and the concentration of S can be above 10 wt%. For the non-red portion the main chemical compositions are Al2O3 and SiO2. The obtained chemical compositions are close to those of kaolinite for Balin chicken-blood stone, and of pyrophyllite for Changhua chicken-blood stone, respectively. So far many Changhua chicken-blood stones and Balin chicken-blood stones were found in China, the PIXE method can be used to explore the provenance of available chicken-blood stones. (author)

  19. EFFICIENCY ANALYSIS OF GAS ENGINES MONOSPARK AND MULTISPARK IGNITION SYSTEMS

    Directory of Open Access Journals (Sweden)

    F. Abramchuk

    2014-02-01

    Full Text Available The results of comparison analysis of gas engine monospark and multispark ignition systems indices are presented. The results of these systems experimental investigation are given.

  20. Determination of cis-permethrin, trans-permethrin and associated metabolites in rat blood and organs by gas chromatography-ion trap mass spectrometry.

    Science.gov (United States)

    Lestremau, F; Willemin, M-E; Chatellier, C; Desmots, S; Brochot, C

    2014-05-01

    An analytical method was developed to measure cis-permethrin and trans-permethrin in different biological rat matrices and fluids (whole blood, red blood cells, plasma, brain, liver, muscle, testes, kidneys, fat and faeces). The method was also suitable for the simultaneous quantification of their associated metabolites [cis-3-(2,2-dichlorovinyl)-2,2-dimethyl-(1-cyclopropane) carboxylic acid (cis-DCCA), trans-3-(2,2-dichlorovinyl)-2,2-dimethyl-(1-cyclopropane) carboxylic acid (trans-DCCA) and 3-phenoxybenzoic acid (3-PBA)] in blood (whole blood, red blood cells, plasma) and liver. The target analytes were derivatised in samples using a methanolic/hydrochloric acid solution and then extracted with toluene. The analysis was performed by gas chromatography, and detection using ion trap tandem mass spectrometry. The selectivity obtained for complex matrices such as rat organs allowed the use of a purification step to be avoided for most of the matrices investigated. In the case of fat, where permethrin is suspected to accumulate, a dedicated purification step was developed. In fluids, the limits of quantification were at the 50 ng/mL level for the parent compounds and 3-PBA and at 25 ng/mL for cis-DCCA and trans-DCCA. For solid matrices excluding fat, the limits of quantification ranged from 50 ng/g for muscle to 100 ng/g for brain and testes for both cis-permethrin and trans-permethrin. The extraction recoveries ranged primarily between 80 and 120% for the matrix tested. The stability of blood samples was tested through the addition of 1% v/v formic acid. The methods developed were applied in a toxicokinetic study in adult rats. cis-Permethrin and the metabolites were detected in all corresponding matrices, whereas trans-permethrin was detected only in blood, plasma and faeces. PMID:24718437

  1. Cooled gas turbine blade edge flow analysis

    Energy Technology Data Exchange (ETDEWEB)

    Mendonca, Marcio Teixeira de [Instituto Tecnologico de Aeronautica, Divisao de Engenharia Mecanica Aeronautica ITA/IEM, Sao Jose dos Campos, SP (Brazil)], e-mail: marcio@ita.br

    2010-07-01

    The flow on the rotating blades of a turbine is unsteady due to the wake of the stator blade row upstream. This unsteadiness is a source of losses and complex flow structures on the rotor blade due to the variation on the turbulence levels and location of the boundary layer laminar to turbulent transition. Convective cooled blades often time have cooling air ejected at the trailing edge right at the blade wake. The present investigation presents an analysis of a canonical flow consistent with the flow topology found at the trailing edge of a gas turbine blade with coolant ejection. A hydrodynamic stability analysis is performed for the combined wake and jet velocity profiles given by a gaussian distribution representing the turbulent rms wake and a laminar jet superposed. The growth rate of any instability found on the flow is an indication of faster mixing, resulting in a reduction on the wake velocity defect and consequently on the complexity associated with it. The results show that increasing the Mach number or the three-dimensionality of the disturbances result in a reduction of the amplification rate. When the flow at the trailing edge is modified by a jet, the amplification rates are lower, but the range of unstable stream wise wavenumbers is larger. (author)

  2. Simulation Analysis of Indoor Gas Explosion Damage

    Institute of Scientific and Technical Information of China (English)

    钱新明; 陈林顺; 冯长根

    2003-01-01

    The influence factors and process of indoor gas explosion are studied with AutoReaGas explosion simulator. The result shows that venting pressure has great influence on the indoor gas explosion damage. The higher the venting pressure is, the more serious the hazard consequence will be. The ignition location has also evident effect on the gas explosion damage. The explosion static overpressure would not cause major injury to person and serious damage to structure in the case of low venting pressure (lower than 2 kPa). The high temperature combustion after the explosion is the major factor to person injury in indoor gas explosion accidents.

  3. Performance-analysis-based gas turbine diagnostics: a review.

    OpenAIRE

    Li, Y.G.

    2002-01-01

    Gas turbine diagnostics has a history almost as long as gas turbine development itself. Early engine fault diagnosis was carried out based on manufacturer information supplied in a technical manual combined with maintenance experience. In the late 1960’s when Urban introduced Gas Path Analysis, gas turbine diagnostics made a big breakthrough. Since then different methods have been developed and used in both aero and industrial applications. Until now a substantial number of papers have been p...

  4. The Analysis of Russian Oil and Gas Reserves

    OpenAIRE

    Yulia Grama

    2012-01-01

    This paper devotes to the analysis of Russian oil and gas reserves. Currently, Russia holds world’s leading positions in oil and gas supply, but there is uncertainty for how long the country would be able to maintain it. After analyzing the situation in this industry, studying oil and gas fields and governmental policy towards hydro carbonates production and supply in Russia, the author will provide her projection about the future development of Russian oil and gas supplies to the global mark...

  5. Functional proteomic analysis of Ankaferd® Blood Stopper

    Directory of Open Access Journals (Sweden)

    Duygu Özel Demiralp

    2010-06-01

    Full Text Available Objective: Ankaferd® Blood Stopper (ABS comprises a standardized mixture of the plants Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica dioica. The basic mechanism of action for ABS is the formation of an encapsulated protein network that provides focal points for vital erythrocyte aggregation. ABS–induced protein network formation with blood cells, particularly erythrocytes, covers the primary and secondary hemostatic system without disturbing individual coagulation factors. Materials and Methods: To understand the effect mechanisms of ABS on hemostasis, a proteomic analysis using 2D gel electrophoresis and mass spectrometer was performed. Results: Proteins of plant origin in Ankaferd® were NADP-dependent-malic enzyme, ribulose bisphosphate-carboxylase-large chain, maturase K, ATP synthase subunit-beta, ATP synthase subunit-alpha, chalcone-flavanone isomerase-1, chalcone-flavanone isomerase-2, and actin-depolymerizing factor. Furthermore, functional proteomic studies revealed that proteins resembling human peptides have been detected within Ankaferd®, including ATP synthase, mucin-16 (CD164 sialomucin-like 2 protein, coiled-coil domain containing 141 hypothetical protein LOC283638 isoform 1, hypothetical protein LOC283638 isoform 2, dynactin 5, complex I intermediate-associated protein 30, mitochondrial, NADH dehydrogenase (ubiquinone 1 alpha subcomplex, TP synthase, H+ transporting, mitochondrial actin binding 1 isoform, LIM domain and actin binding 1 isoform a, LIM domain and actin binding 1 isoform b, spectrin alpha non erythrocytic 1, prolactin releasing hormone receptor, utrophin, tet oncogene family member 2 isoform b, protein phosphatase 1 regulatory subunit 12A, NIMA (never in mitosis gene a-related kinase, ATP-binding cassette protein C12, Homo sapiens malic enzyme 1, mitochondrial NADP(+-dependent malic enzyme 3, ME2 protein, nuclear factor 1 B-type, abhydrolase domain-containing protein 12B, E

  6. Thermodynamic Analysis of Supplementary-Fired Gas Turbine Cycles

    DEFF Research Database (Denmark)

    Elmegaard, Brian; Henriksen, Ulrik Birk; Qvale, Einar Bjørn

    2003-01-01

    This paper presents an analysis of the possibilities for improving the efficiency of an indi-rectly biomass-fired gas turbine (IBFGT) by supplementary direct gas-firing. The supple-mentary firing may be based on natural gas, biogas or pyrolysis gas. Intuitively, sup-plementary firing is expected to...... the recu-perated gas turbine. Instead, other process changes may be considered in order to obtain a high marginal efficiency on natural gas. Two possibilities are discussed: Integration between an IFGT and pyrolysis of the biofuel which will result in a highly efficient utilization of the biomass, and...... indirectly fired gas turbine (IFGT) and for the supplementary-fired IFGT. These results show that the combination of external firing and internal firing have the potential of reducing or solving some problems associated with the use of biomass both in the recuperated and the indirectly fired gas turbine: The...

  7. Clinical value of blood gas analysis in the early prognosis of severe acute pancreatitis%动静脉血气分析在重症胰腺炎患者早期预后判断中的临床价值

    Institute of Scientific and Technical Information of China (English)

    李晓; 高伟芳; 桑荣霞; 张纪元; 胡静; 刘润; 韩占波

    2016-01-01

    decreased, and the level in the survival group was significantly lower than that in death group [(1.47 ± 0.50) mmol/L vs (1.22 ± 0.38) mmol/L,P<0.05]. In order to determine the value of PCO2, HCO3-and BE in the prognosis of patients with SAP, the ROC curves were used to calculate the accuracy rate of prognosis of patients with SAP. The area under the ROC curve of BE and APACHEⅡscore was the largest, which indicated the highest diagnostic accuracy. Conclusion The early detection of blood gas analysis in patients with SAP is more conducive to the judg-ment of prognosis. The prognosis of patients with bigger negative BE score and older age may be poor.

  8. Gas exchange as monitored in mixed venous and arterial blood during experimental cardiopulmonary resuscitation.

    Science.gov (United States)

    Wiklund, L; Jorfeldt, L; Stjernström, H; Rubertsson, S

    1992-07-01

    Nineteen anaesthetized piglets were investigated. After catheterization and a stabilization period, ventricular fibrillation was induced with a transthoracic DC shock, after which a 10-min period of cardiopulmonary resuscitation (CPR) took place. CPR included manual chest compression and mechanical ventilation with pure oxygen. After 1 min of CPR, an infusion of alkaline buffer was begun and completed within 5 min. A total of 50 mmol of either sodium bicarbonate (n = 6) or tris buffer mixture (n = 7) were given. These two groups were compared with a third control group (n = 6) receiving the same volume of normal saline. After 8 min of CPR all animals were given 0.5 mg adrenaline i.v., and after 10 min DC shocks were used to revert the heart back to normal sinus rhythm. Our results demonstrate that blood flow and not ventilation is the limiting factor for the efficient disposal of CO2 during CPR. This also applied when the demand for CO2 transport was increased by administration of sodium bicarbonate. The respiratory exchange ratio increased 1.9-fold, indicating that the transport of carbon dioxide was less affected than that of oxygen. The estimated alveolo-arterial oxygen tension difference, shunt, and overall ventilation/perfusion ratio increased, creating an inverse hyperbolic relationship between arterial PCO2 and PO2. The difference between mixed venous and arterial PCO2 correlated well to the mixed venous PCO2, implying more efficient pulmonary elimination of PCO2 when the mixed venous PCO2 was high. Pulmonary gas exchange during CPR appears to be independent of alkaline buffer therapy in the form of sodium bicarbonate or tris buffer mixture.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:1632165

  9. Uranium trace analysis in human blood using fission track technique

    International Nuclear Information System (INIS)

    Fission track technique makes the measurement of the content of uranium in human blood. By choosing solid state nuclear track detectors of the high sensitivity, uranium can be determined using U(n,f) reaction. Blood samples are directly taken from finger and irradiated in a nuclear reactor at a thermal neutron flux of 3.5 x 1016 n/cm2. In normal human blood, the uranium contents varied from 2.43 to 3.80 x 10-10 g/ml, the average of the values is (3.06 ± 0.10) x 10-10 g/ml. In U-exposed workers blood, it varied from 3.07 to 5.57 x 10-10 g/ml, the average value is (4.53 ± 0.12) x 10-10 g/ml. In leukemia patients blood, 3.90 to 12.07 x 10-10 g/ml, the mean U-content is (7.74 ± 0.15) x 10-10 g/ml, which is 2.5 times higher than the mean of normal human blood. These results show a possible relation between the leukemia and the uranium content in the blood. If there is such a relationship, the Nuclear Fission Track Technique will be an important diagnostic tool in medicine

  10. Analysis of blood and tissue in gallbladder cancer

    Energy Technology Data Exchange (ETDEWEB)

    Rautray, T.R. [Department of Dental Biomaterials, School of Dentistry, Kyungpook National University, 2-188-1 Samduk-dong, Jung-gu, Daegu (Korea, Republic of)], E-mail: tapash77@hotmail.com; Vijayan, V. [Dept. of Physics, Valliammai Engineering College, SRM Nagar, Chennai (India); Sudarshan, M. [UGC-DAE Consortium for Scientific Research, Kolkata Centre, 3/LB-8 Bidhan Nagar, Kolkata 700 098, West Bengal (India); Panigrahi, S. [Dept. of Physics, National Institute of Technology, Rourkela 769 008, Orissa (India)

    2009-09-01

    Particle induced X-ray emission, particle induced {gamma}-ray emission studies has been carried out to analyse normal and carcinoma tissues and blood samples of gallbladder of both sexes and seventeen trace elements namely Na, Mg, Al, K, Ca, Ti, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Br and Pb were estimated in the tissue and blood samples. In the present study, concentration of Zn in the carcinoma gallbladder tissue is less than that of the normal gallbladder tissue. Tobacco habit could be one of the important factors to decrease the elemental concentrations in blood and tissue samples.

  11. Blood gas and patient safety: considerations based on experience developed in accordance with the Risk Management perspective.

    Science.gov (United States)

    Rambaldi, Marco; Baranzoni, Mariateresa; Coppolecchia, Pasquale; Moschello, Jennifer N; Novaco, Francesca

    2007-01-01

    It is the responsibility of health organizations to guarantee a high level of healthcare by using adequate methodologies and instruments, creating secure conditions for treatment, and preventing adverse events due to human or system errors. It is necessary to introduce Risk Management programs, and in particular to promote Clinical Risk Management, one of the constituent elements of Clinical Governance, to assure the delivery of high-quality performance and services. In the point-of-care testing (POCT) context, using an analysis of our experiences, we discuss the entire analytical process, including acquisition and usage, while focusing on blood gas analyzers. Our experience confirms that within a Clinical Governance framework, it is necessary to apply, even when choosing instruments, a systematic vision that is not limited to analytical validation, but also includes an in-depth analysis of the impact in a specific context. Assessment of the correlated risks, independent of the analytical methodology used, is indispensable in a clinical environment to identify the most suitable approach for such risks. A study of the latent factors can be proactively performed to identify (and stimulate) what the pre-organizational environment (producer companies) can offer in terms of product orientation to effectively reduce correlated risk during use. Among the different options for possible treatment of risk, one involves the transfer of the assumption of risk to third parties (e.g., maintenance and quality controls). Transferring the responsibility for control operations to the operator of the instrument, which follows the quality controls with total autonomy, is equivalent to transferring the correlated risk for the clinician (in the POCT case) to the producer, who becomes the guarantor. In practice this is equivalent to a specific assurance stipulation with zero cost. PMID:17579531

  12. Analysis of gas dispersed in scattering media

    OpenAIRE

    Sjöholm, Mikael; Somesfalean, Gabriel.; Alnis, J.; Andersson-Engels, Stefan; Svanberg, Sune

    2001-01-01

    Monitoring of free gas embedded in scattering media, such as wood, fruits, and synthetic materials, is demonstrated by use of diode laser spectroscopy combined with sensitive modulation techniques. Gas detection is made possible by the contrast of the narrow absorptive feature of the free-gas molecules with the slow wavelength dependence of the absorption and scattering cross sections in solids and liquids. An absorption sensitivity of 2.5 x 10(-4), corresponding to a 1.25-mm air column, is d...

  13. Microfluidic Cytometer for Complete Blood Count Analysis Project

    Data.gov (United States)

    National Aeronautics and Space Administration — RMD proposes to develop a MEMS based complete blood count (CBC) instrument that can be used aboard a spacecraft. We will produce a microfluidic scale combination...

  14. Reagents for Lithium Electrodes and Sensors for Blood Serum Analysis

    Directory of Open Access Journals (Sweden)

    Gary D. Christian

    2002-10-01

    Full Text Available The measurement of lithium in blood serum requires high selectivity since the blood contains about 140 mM sodium compared to the 0.5-1.5 mM lithium level in manic depressive patients under treatment with lithium salts. This review traces the development of optical and potentiometric methods for the selective measurement of lithium in the presence of sodium. Selectivities of over 1,000:1 are achievable with properly designed ionophores.

  15. Transcriptome analysis of Neisseria meningitidis in human whole blood and mutagenesis studies identify virulence factors involved in blood survival.

    Directory of Open Access Journals (Sweden)

    Hebert Echenique-Rivera

    2011-05-01

    Full Text Available During infection Neisseria meningitidis (Nm encounters multiple environments within the host, which makes rapid adaptation a crucial factor for meningococcal survival. Despite the importance of invasion into the bloodstream in the meningococcal disease process, little is known about how Nm adapts to permit survival and growth in blood. To address this, we performed a time-course transcriptome analysis using an ex vivo model of human whole blood infection. We observed that Nm alters the expression of ≈30% of ORFs of the genome and major dynamic changes were observed in the expression of transcriptional regulators, transport and binding proteins, energy metabolism, and surface-exposed virulence factors. In particular, we found that the gene encoding the regulator Fur, as well as all genes encoding iron uptake systems, were significantly up-regulated. Analysis of regulated genes encoding for surface-exposed proteins involved in Nm pathogenesis allowed us to better understand mechanisms used to circumvent host defenses. During blood infection, Nm activates genes encoding for the factor H binding proteins, fHbp and NspA, genes encoding for detoxifying enzymes such as SodC, Kat and AniA, as well as several less characterized surface-exposed proteins that might have a role in blood survival. Through mutagenesis studies of a subset of up-regulated genes we were able to identify new proteins important for survival in human blood and also to identify additional roles of previously known virulence factors in aiding survival in blood. Nm mutant strains lacking the genes encoding the hypothetical protein NMB1483 and the surface-exposed proteins NalP, Mip and NspA, the Fur regulator, the transferrin binding protein TbpB, and the L-lactate permease LctP were sensitive to killing by human blood. This increased knowledge of how Nm responds to adaptation in blood could also be helpful to develop diagnostic and therapeutic strategies to control the devastating

  16. PERFORMANCE MODELING AND ANALYSIS OF BLOOD FLOW IN ELASTIC ARTERIES

    Institute of Scientific and Technical Information of China (English)

    Anil Kumar; C.L. Varshney; G.C. Sharma

    2005-01-01

    Two different non-Newtonian models for blood flow are considered, first a simple power law model displaying shear thinning viscosity, and second a generalized Maxwell model displaying both shear thinning viscosity and oscillating flow viscous-elasticity. These models are used along with a Newtonian model to study sinusoidal flow of blood in rigid and elastic straight arteries in the presence of magnetic field. The elasticity of blood does not appear to influence its flow behavior under physiological conditions in the large arteries,purely viscous shear thinning model should be quite realistic for simulating blood flow under these conditions. On using the power law model with high shear rate for sinusoidal flow simulation in elastic arteries, the mean and amplitude of the flow rate were found to be lower for a power law fluid compared to Newtonian fluid for the same pressure gradient. The governing equations have been solved by Crank-Niclson scheme. The results are interpreted in the context of blood in the elastic arteries keeping the magnetic effects in view. For physiological flow simulation in the aorta, an increase in mean wall shear stress, but a reduction in peak wall shear stress were observed for power law model compared to a Newtonian fluid model for matched flow rate wave form. Blood flow in the presence of transverse magnetic field in an elastic artery is investigated and the influence of factors such as morphology and surface irregularity is evaluated.

  17. A historical analysis of natural gas demand

    Science.gov (United States)

    Dalbec, Nathan Richard

    This thesis analyzes demand in the US energy market for natural gas, oil, and coal over the period of 1918-2013 and examines their price relationship over the period of 2007-2013. Diagnostic tests for time series were used; Augmented Dickey-Fuller, Kwiatkowski-Phillips-Schmidt-Shin, Johansen cointegration, Granger Causality and weak exogeneity tests. Directed acyclic graphs were used as a complimentary test for endogeneity. Due to the varied results in determining endogeneity, a seemingly unrelated regression model was used which assumes all right hand side variables in the three demand equations were exogenous. A number of factors were significant in determining demand for natural gas including its own price, lagged demand, a number of structural break dummies, and trend, while oil indicate some substitutability with natural gas. An error correction model was used to examine the price relationships. Natural gas price was found not to have a significant cointegrating vector.

  18. Analysis of Natural Gas Vehicle Industry : none

    OpenAIRE

    Li, Zhen

    2014-01-01

    A vehicle powered by natural gas is becoming a prevalent trend and direction in automobile manufacturing. The thesis is aiming at analyzing the natural gas vehicle industry from its environmental effectiveness, economic effectiveness, recent status and its development in the near future with statistical data. And also it will find out the potential problems and relevant technologies. Investigation and literature research method are mainly used to fully collect the correct information and d...

  19. Thermodynamic Analysis of Supplementary-Fired Gas Turbine Cycles

    DEFF Research Database (Denmark)

    Elmegaard, Brian; Henriksen, Ulrik Birk; Qvale, Einar Bjørn

    2002-01-01

    This paper presents an analysis of the possibilities for improving the efficiency of an indirectly biomass-fired gas turbine (IBFGT) by supplementary direct gas-firing. The supplementary firing may be based on natural gas, biogas, or pyrolysis gas. {The interest in this cycle arise from a recent...... requires a clean, expensive fuel. The latter is limited in efficiency due to limitations in material temperature of the heat exchanger. Thus, in the case of an IBFGT, it would be very appropriate to use a cheap biomass or waste fuel for low temperature combustion and external firing and use natural gas at...... analysed: Integration between an IFGT and pyrolysis of the biofuel which will result in a highly efficient utilization of the biomass, and integration between external biomass firing, internal biomass firing and internal natural gas firing. The marginal efficiency of the natural gas is in this case found...

  20. Method development of gas analysis with mass spectrometer

    International Nuclear Information System (INIS)

    Dissolved gas content in deep saline groundwater is an important factor, which has to be known and taken into account when planning the deep repository for the spent nuclear fuel. Posiva has investigated dissolved gases in deep groundwaters since the 1990's. In 2002 Posiva started a project that focused on developing the mass spectrometric method for measuring the dissolved gas content in deep saline groundwater. The main idea of the project was to analyse the dissolved gas content of both the gas phase and the water phase by a mass spectrometer. The development of the method started in 2003 (in the autumn). One of the aims was to create a parallel method for gas analysis with the gas chromatographic method. The starting point of this project was to test if gases could be analysed directly from water using a membrane inlet in the mass spectrometer. The main objective was to develop mass spectrometric methods for gas analysis with direct and membrane inlets. An analysis method for dissolved gases was developed for direct gas inlet mass spectrometry. The accuracy of the analysis method is tested with parallel real PAVE samples analysed in the laboratory of Insinoeoeritoimisto Paavo Ristola Oy. The results were good. The development of the membrane inlet mass spectrometric method still continues. Two different membrane materials (silicone and teflon) were tested. Some basic tests (linearity,repeatability and detection limits for different gases) will be done by this method. (orig.)

  1. Hemogasometria e ânion gap em equinos tratados com soluções eletrolíticas enterais contendo diferentes fontes de energia Blood gas analysis and anion gap in horses treated with enteral electrolyte solutions containing different energy sources

    Directory of Open Access Journals (Sweden)

    Sheila Kreutzfeld de Farias

    2011-09-01

    chloride, 0.2g of magnesium pidolate, 1g of calcium gluconate and 10g of maltodextrin diluted in 1.000mL of water. The osmolality measured was of 181mOsmol L-1 and SEProp - 5g of sodium chloride, 0.5g of potassium chloride, 0.2g of magnesium pidolate, 1g of calcium gluconate and 10g of calcium propionate diluted in 1.000mL of water. The osmolality measured was of 282mOsm L-1. The electrolyte solutions were administered in a dose of 15mL kg-1 h-1 for 12 hours. The treatments with enteral electrolyte solutions containing dextrose, maltodextrin and calcium propionate did not change blood gas analysis values in these animals.

  2. The Analysis of Russian Oil and Gas Reserves

    Directory of Open Access Journals (Sweden)

    Yulia Grama

    2012-01-01

    Full Text Available This paper devotes to the analysis of Russian oil and gas reserves. Currently, Russia holds world’s leading positions in oil and gas supply, but there is uncertainty for how long the country would be able to maintain it. After analyzing the situation in this industry, studying oil and gas fields and governmental policy towards hydro carbonates production and supply in Russia, the author will provide her projection about the future development of Russian oil and gas supplies to the global market.

  3. Evolved gas analysis of hydrated phases in Murchison and Orgueil

    OpenAIRE

    Morris, A.A.; Baker, L; Franchi, I.A.; Wright, I. P.

    2005-01-01

    To better characterise the hydrated minerals in chondrites Evolved Gas Analysis of Murchison, Orgueil and selected minerals has been carried out. Meteorite water release profiles show significant differences to expected reference minerals.

  4. Dynamical Analysis in the Mathematical Modelling of Human Blood Glucose

    Science.gov (United States)

    Bae, Saebyok; Kang, Byungmin

    2012-01-01

    We want to apply the geometrical method to a dynamical system of human blood glucose. Due to the educational importance of model building, we show a relatively general modelling process using observational facts. Next, two models of some concrete forms are analysed in the phase plane by means of linear stability, phase portrait and vector…

  5. Modified mouse peripheral blood lymphocyte culture system for cytogenetic analysis

    International Nuclear Information System (INIS)

    A detailed methodology is presented for culturing mouse peripheral blood lymphocytes isolated on density gradients and stimulated to divide using either phytohemagglutinin, concanavalin A, or lipopolysaccharide. The techniques described yield more than sufficient numbers of mitotic cells for analyzing sister chromatid exchange, chromosome, aberrations, and micronuclei following in vitro or in vivo exposure to chemicals or radiation

  6. Using skills of ABL80 FLEX blood gas analyzer in ICU%ICU科内ABL80 FLEX血气分析仪使用技巧

    Institute of Scientific and Technical Information of China (English)

    刘颖; 席廷阳; 苏春燕; 王璇

    2015-01-01

    血气分析技术一直在临床手术、抢救与监护过程中发挥着至关重要的作用,但如使用不当会导致仪器设备发生故障,减少仪器使用寿命,进而影响患者的救治。本文总结了多年在ICU 工作的科内血气分析仪使用的经验,期望能对初入ICU的同行有所帮助。%Blood gas analysis played a vital role in the process of clinical surgery, rescue and care�Yet improper use can result in equipment failure, reduce the service life of the instrument, and then affect the treatment of the patients� This article summarized the working experience for ABL80 FLEX blood gas analyzer in ICU to help new ICU nurses.

  7. Thermodynamic Analysis of Supplementary-Fired Gas Turbine Cycles

    DEFF Research Database (Denmark)

    Elmegaard, Brian; Henriksen, Ulrik Birk; Qvale, Einar Bjørn

    2003-01-01

    This paper presents an analysis of the possibilities for improving the efficiency of an indi-rectly biomass-fired gas turbine (IBFGT) by supplementary direct gas-firing. The supple-mentary firing may be based on natural gas, biogas or pyrolysis gas. Intuitively, sup-plementary firing is expected to...... former requires a clean, expensive fuel. The latter is limited in efficiency due to limita-tions in material temperature of the heat exchanger. Thus, in the case of an IBFGT, it would appear be very appropriate to use a cheap biomass or waste fuel for low tempera-ture combustion and external firing and...... the recu-perated gas turbine. Instead, other process changes may be considered in order to obtain a high marginal efficiency on natural gas. Two possibilities are discussed: Integration between an IFGT and pyrolysis of the biofuel which will result in a highly efficient utilization of the biomass, and...

  8. In Vivo Measurements Of Coronary Blood Volumi By Dye And Inert Gas Dilution Technic

    Science.gov (United States)

    Hoeft, A.; Korb, H.; Wolpers, H. G.

    1984-10-01

    The application of a double fiberoptic device for measurements of arterial and coronary venous dye dilution curves facilitates the determination of coronary mean transit times even under clinical conditions. Since the dye, indocyanine green, is an intravascular tracer, the calculation of tissue blood flow would be possible if the intracoronary blood volume per unit of muscular weight is known. This study was therefore designed to investigate the physiologic range and the influence of coronary vasodilation and different hemodynamic conditions on the amount of myocardial blood volume. All experiments were carried out on anaesthetized close chest mongrel dogs in heart catheterization technic. Myocardial preload, afterload and inotropism and coronary vascular tone were varied by induction of hypo-, normo- and hypervolemia as well as by intravenous application of catecholamines, 13-blocking agents and vasodilating drugs. The determination of coronary blood volume was based on arterial and coronary venous kinetics of the intravascular tracer indocyanine green and the freely diffusible tracers helium and argon. Simultaneous measurements of the dye and the inert gases were obtained by a double fiberoptic system and a twin mass spectrometer, respectively. The intravascular and the tissue mean transit times as well as the coronary blood volume per unit of tissue weight were computed from the impulse response functions obtained by numerical deconvolution of the arterial and coronary venous indicator dilution curves. In contrast to reports of other authors coronary blood volume did not increase to a major extend during coronary vasodilation or elevated afterload. These new results suggest that the variation of coronary blood volume described in the literature is mainly due to methodological errors resulting from monoexponential extrapolation and distortion of the dye signal by the sampling catheter. These systematic errors, which, in particular, lead to an overestimation of

  9. Changes in pulmonary blood flow do not affect gas exchange during intermittent ventilation in resting turtles

    DEFF Research Database (Denmark)

    Wang, Tobias; Hicks, James W.

    2008-01-01

    The breathing pattern of many different air-breathing vertebrates, including lungfish, anuran amphibians, turtles, crocodiles and snakes, is characterized by brief periods of lung ventilation interspersed among apnoeas of variable duration. These intermittent ventilatory cycles are associated......2 excretion did not correlate with changes in pulmonary blood flow. We conclude that increases in pulmonary blood flow associated with ventilation are not required to maintain resting rates of oxygen uptake and CO2 excretion in resting animals....

  10. Analysis of Ca and Mg in blood of golden hamster using NAA technique

    Energy Technology Data Exchange (ETDEWEB)

    Aguiar, Rodrigo O.; Zamboni, Cibele B.; Medeiros, Jose A.G. [Instituto de Pesquisas Energeticas e Nucleares (IPEN-CNEN/SP), Sao Paulo, SP (Brazil)], e-mail: rodrigoaguiar@usp.br, e-mail: czamboni@ipen.br, e-mail: jageiros@yahoo.com.br

    2009-07-01

    Neutron activation analysis (NAA) technique has been used to determine simultaneously Ca and Mg concentrations in whole blood of Golden Hamster. The reference values for Ca (0.17 - 0.29 gL{sup -1} ) and Mg (0.042 - 0.074 gL{sup -1} ) can be used to performed biochemistry investigation using whole blood. (author)

  11. Analysis of Ca and Mg in blood of golden hamster using NAA technique

    International Nuclear Information System (INIS)

    Neutron activation analysis (NAA) technique has been used to determine simultaneously Ca and Mg concentrations in whole blood of Golden Hamster. The reference values for Ca (0.17 - 0.29 gL-1 ) and Mg (0.042 - 0.074 gL-1 ) can be used to performed biochemistry investigation using whole blood. (author)

  12. Institutional Knots: A Comparative Analysis of Cord Blood Policy in Canada and the United States.

    Science.gov (United States)

    Denburg, Avram

    2016-02-01

    Umbilical cord blood is a rich source of blood stem cells, which are of critical clinical importance in the treatment of a variety of malignant and genetic conditions requiring stem cell transplantation. Many countries have established national public cord blood banks; such banks often coexist with a panoply of private options for cord blood banking. Until recently, Canada was the only G8 country without a national cord blood bank. This differs markedly from the United States, which years ago established a national cord blood bank policy and inventory. This article investigates potential reasons for this discrepancy through a comparative analysis of the evolution of programs and policies on national cord blood banking in Canada and the United States. My analysis suggests that cross-national discrepancies in policy on public cord blood banking were determined primarily by institutional factors, principal among them formal governmental structure and the legacy of past policies. Institutional entrepreneurialism in the health sector played a constitutive role in the earlier evolution of national cord blood policy in the United States as compared to Canada. PMID:26567379

  13. Gas analysis system for ageing studies of gaseous radiation detectors

    International Nuclear Information System (INIS)

    A special gas analysis system has been constructed to analyze compounds created in electron avalanches in gaseous radiation detectors during their operation. The analysis method is based on utilisation of cryogenic concentration unit connected to a tandem gas chromatograph and a mass spectrometer. The system has been designed for quantitative analysis of organic compounds potentially involved in ageing processes of detectors. It can be exploited to identify compounds prone to polymerise and to measure variation of compounds as a function of detector construction materials and additives in the gas mixture. As a quantitative instrument it can be used to measure dependence of concentration of compounds on operating parameters of detectors, e.g. gas amplification and irradiation rate and type

  14. Gas chromatography mass spectrometry computer analysis of volatile halogenated hydrocarbons in man and his environment--A multimedia environmental study.

    Science.gov (United States)

    Barkley, J; Bunch, J; Bursey, J T; Castillo, N; Cooper, S D; Davis, J M; Erickson, M D; Harris, B S; Kirkpatrick, M; Michael, L C; Parks, S P; Pellizzari, E D; Ray, M; Smith, D; Tomer, K B; Wagner, R; Zweidinger, R A

    1980-04-01

    As part of a study to make a comparative analysis of selected halogenated compounds in man and the environmental media, a quantitative gas chromatography mass spectrometric analysis of the levels of the halogenated compounds found in the breath, blood and urine of an exposed population (Old Love Canal area, Niagara, New York) and their immediate environment (air and water) was undertaken. In addition, levels of halogenated hydrocarbons in air samples taken in the general Buffalo, Niagara Falls area were determined. PMID:7448328

  15. Numerical Analysis of the FDA Centrifugal Blood Pump

    OpenAIRE

    Marinova, V.; Kerroumi, I.; Lintermann, Andreas; Göbbert, Jens Henrik; Moulinec, C.; Rible, S.; Fournier, Y.; Behbahani, M.

    2016-01-01

    Ventricular Assist Devices (VADs) are commonly implanted to assist patients suffering fromheart diseases. They provide long- and short-term support for the human heart and help patientsto recover from heart attacks and from congestive heart failure. It is essential to design bloodsensitiveVADs to minimise the risk of hemolysis and thrombosis. The blood pump, however,must operate at a wide range of flow rates and pressure heads which makes a low-risk design achallenging task. In this study the...

  16. Changes in blood gas transport of altitude native soccer players near sea-level and sea-level native soccer players at altitude (ISA3600)

    OpenAIRE

    Wachsmuth, Nadine; Kley, Marlen; Spielvogel, Hilde; Aughey, Robert J; Gore, Christopher J; Bourdon, Pitre C.; Hammond, Kristal; Sargent, Charli; Roach, Gregory D.; Sanchez, Rudy Soria; Claros, Jesus C Jimenez; Schmidt, Walter F; Garvican-Lewis, Laura A

    2013-01-01

    Objectives The optimal strategy for soccer teams playing at altitude is not known, that is, ‘fly-in, fly-out’ versus short-term acclimatisation. Here, we document changes in blood gas and vascular volumes of sea-level (Australian, n=20) and altitude (Bolivian, n=19) native soccer players at 3600 m. Methods Haemoglobin-oxygen saturation (Hb-sO2), arterial oxygen content (CaO2), haemoglobin mass (Hbmass), blood volume (BV) and blood gas concentrations were measured before descent (Bolivians onl...

  17. Prehospital point of care testing of blood gases and electrolytes — an evaluation of IRMA

    OpenAIRE

    Prause, Gerhard; Ratzenhofer-Komenda, Beatrice; Offner, Anton; Lauda, Peter; Voit, Henrika; Pojer, Horst

    1997-01-01

    Background: This study evaluated the feasibility of blood gas analysis and electrolyte measurements during emergency transport prior to hospital admission. Results: A portable, battery-powered blood analyzer was used on patients in life threatening conditions to determine pH, pCO2, pO2, sodium, potassium and ionized calcium. Arterial blood was used for blood gas analysis and electrolyte measurements. Venous blood was used for electrolyte measurement alone. During the observation period of 4 m...

  18. Spectral analysis of heart rate and blood pressure variability in primary Sjogren's syndrome

    NARCIS (Netherlands)

    P.J. Barendregt (Pieternella); J.H.M. Tulen (Joke); A.H. van den Meiracker (Anton); H.M. Markusse

    2002-01-01

    textabstractBACKGROUND: Autonomic dysfunction has been described in primary Sjogren's syndrome (SS). OBJECTIVE: To investigate the circulatory autonomic regulation in patients with primary SS by power spectral analysis of heart rate and blood pressure variability. METHODS: Forty th

  19. Use of a blood gas analyzer and a laboratory autoanalyzer in routine practice to measure electrolytes in intensive care unit patients

    Directory of Open Access Journals (Sweden)

    Budak Yasemin U

    2012-08-01

    Full Text Available Abstract Background Electrolyte values are measured in most critically ill intensive care unit (ICU patients using both an arterial blood gas analyzer (ABG and a central laboratory auto-analyzer (AA. The aim of the present study was to investigate whether electrolyte levels assessed using an ABG and an AA were equivalent; data on sodium and potassium ion concentrations were examined. Methods We retrospectively studied patients hospitalized in the ICU between July and August 2011. Of 1,105 test samples, we identified 84 instances of simultaneous sampling of arterial and venous blood, where both Na+ and K+ levels were measured using a pHOx Stat Profile Plus L blood gas analyzer (Nova Biomedical, Waltham MA, USA and a Roche Modular P autoanalyzer (Roche Diagnostics, Mannheim, Germany. Statistical measures employed to compare the data included Spearman's correlation coefficients, paired Student’s t-tests, Deming regression analysis, and Bland-Altman plots. Results The mean sodium concentration was 138.1 mmol/L (SD 10.2 mmol/L using the ABG and 143.0 mmol/L (SD 10.5 using the AA (p + and Na+, with biases of 0.150-0.352 and −0.97-10.05 respectively; the associated correlation coefficients were 0.88 and 0.90. Conclusions We conclude that the ABG and AA do not yield equivalent Na+ and K+ data. Concordance between ABG and AA should be established prior to introduction of new ABG systems.

  20. Analysis of blood transfusion predictors in patients undergoing elective oesophagectomy for cancer

    Directory of Open Access Journals (Sweden)

    Welch Neil T

    2008-01-01

    Full Text Available Abstract Background Oesophagectomy for cancers is a major operation with significant blood loss and usage. Concerns exist about the side effects of blood transfusion, cost and availability of donated blood. We are not aware of any previous study that has evaluated predictive factors for perioperative blood transfusion in patients undergoing elective oesophagectomy for cancer. This study aimed to audit the pattern of blood crossmatch and to evaluate factors predictive of transfusion requirements in oesophagectomy patients. Methods Data was collected from the database of all patients who underwent oesophagectomy for cancer over a 2-year period. Clinico-pathological data collected included patients demographics, clinical factors, tumour histopathological data, preoperative and discharge haemoglobin levels, total blood loss, number of units of blood crossmatched pre-, intra- and postoperatively, number of blood units transfused, crossmatched units reused for another patient and number of blood units wasted. Clinico-pathological variables were evaluated and logistic regression analysis was performed to determine which factors were predictive of blood transfusion. Results A total of 145 patients with a male to female ratio of 2.5:1 and median age of 68 (40–85 years were audited. The mean preoperative haemoglobin (Hb was 13.0 g/dl. 37% of males (Hb 70 years, Hb level Conclusion The cohort of patients audited was over-crossmatched. The identified independent predictors of blood transfusion should be considered in preoperative blood ordering for oesophagectomy patients. This study has directly led to a reduction in the maximum surgical blood-ordering schedule for oesophagectomy to 2 units and a reaudit is underway.

  1. Residual gas analysis system of synchrotron radiation source Indus-2

    International Nuclear Information System (INIS)

    Indus-2 is a 2.5 GeV e- storage ring dedicated for its application as Synchrotron Radiation Source (SRS) in the X-ray wavelength region. The beam lifetime is expected to be nearly 20 hours at 300 mA beam current with 2.5 GeV energy. The beam lifetime of 2.5 GeV storage ring is mainly dependent on the vacuum in the storage ring and on the species of gas molecules therein. The residual gas analysis provides the information about gas species present in the Indus-2 vacuum envelope. Eleven Residual Gas Analyzers (RGAs) were installed to know about the residual gas species present inside the Indus-2 vacuum system. A short overview of the installed RGA system is given in detail. During Indus-2 operation residual gas analysis is carried out with RGAs at the important locations. RGAs are also used for in-situ leak detection. This paper outlines the present status of Residual Gas Analysis (RGA) System on Indus-2, its performance over the last few years and their application as leak detector in Indus-2. (author)

  2. Analysis of gas turbine integrated cogeneration plant: Process integration approach

    International Nuclear Information System (INIS)

    Cogeneration is defined as generation of two forms of energy viz. heat and work using single primary fuel. Cogeneration or combined heat and power (CHP) is important in improving energy efficiency of the overall plant and in reducing environmental pollution. A methodology, based on pinch analysis, is proposed in this paper to integrate gas turbine and regenerator with a process plant to minimize fuel consumption. Thermodynamic analysis of gas turbine integrated CHP plant is presented on gas turbine pressure ratio versus power to heat ratio diagram. On this novel diagram, limits of integration are identified and various regions of integration are represented. Additionally, contour plots of energy utilization factors and fuel energy saving ratios are represented on this diagram for optimal integration of gas turbine with a process plant. It is interesting to note that though the contour plots of energy utilization factors and fuel energy saving ratios differ significantly, loci of the maximal energy utilization factor and the maximal fuel energy saving ratio are identical. Optimum sizing of gas turbine integrated cogeneration plant for grassroots design and retrofitting are performed based on these diagrams. - Highlights: • Methodology for direct integration of gas turbine, regenerator, and process plant. • Integrated system analysis plotted on turbine pressure ratio vs. power to heat ratio. • Regions of integration are identified on this new diagram. • Variations of energy utilization factor and fuel energy saving ratio are indicated. • Optimal sizing of integrated gas turbine for retrofitting and grassroots design

  3. Numerical Analysis on Transient of Steam-gas Pressurizer

    International Nuclear Information System (INIS)

    In nuclear reactors, various pressurizers are adopted to satisfy their characteristics and uses. The additional active systems such as heater, pressurizer cooler, spray and insulator are essential for a steam or a gas pressurizer. With a steam-gas pressurizer, additional systems are not required due to the use of steam and non-condensable gas as pressure-buffering materials. The steam-gas pressurizer in integrated small reactors experiences very complicated thermal-hydraulic phenomena. To ensure the integrity of this pressurizer type, the analysis on the transient behavior of the steam-gas pressure is indispensable. For this purpose, the steam-gas pressurizer model is introduced to predict the accurate system pressure. The proposed model includes bulk flashing, rainout, inter-region heat and mass transfer and wall condensation with non-condensable gas. However, the ideal gas law is not applied because of significant interaction at high pressure between steam and non-condensable gas. The results obtained from this proposed model agree with those from pressurizer tests. (authors)

  4. A life cycle analysis of the Canadian natural gas system

    International Nuclear Information System (INIS)

    A life cycle analysis (LCA) model has been developed for the Canadian natural gas industry using Battelle's Life-Cycle AdvantageTM model which was developed on behalf of the Canadian Gas Association and the Gas Research Institute of Canada. The model makes it possible to determine cradle to grave emissions of carbon dioxide, methane and nitrous oxides gases through each segment of the Canadian natural gas industry, including upstream, transmission, storage, distribution and end-use. Another advantage of the model is that it allows for a full fuel cycle comparison of natural gas with other fossil fuels on an equivalent end-use energy basis. This information is helpful when dealing with national climate change issues and for determining the role of natural gas in reducing Canada's greenhouse gas emissions as outlined in the Kyoto Protocol. The model was developed to address the need to have a defensible answer to future regulatory requirements regarding the full impact of natural gas systems and end use. This need became apparent with the sharp increase in new natural gas projects throughout Canada. 4 refs., 5 tabs., 2 figs

  5. Validation of the pulse decomposition analysis algorithm using central arterial blood pressure

    OpenAIRE

    Baruch, Martin C; Kalantari, Kambiz; Gerdt, David W; Adkins, Charles M

    2014-01-01

    Background There is a significant need for continuous noninvasive blood pressure (cNIBP) monitoring, especially for anesthetized surgery and ICU recovery. cNIBP systems could lower costs and expand the use of continuous blood pressure monitoring, lowering risk and improving outcomes. The test system examined here is the CareTaker® and a pulse contour analysis algorithm, Pulse Decomposition Analysis (PDA). PDA’s premise is that the peripheral arterial pressure pulse is a superposition of five ...

  6. Multifactorial analysis of human blood cell responses to clinical total body irradiation

    Science.gov (United States)

    Yuhas, J. M.; Stokes, T. R.; Lushbaugh, C. C.

    1972-01-01

    Multiple regression analysis techniques are used to study the effects of therapeutic radiation exposure, number of fractions, and time on such quantal responses as tumor control and skin injury. The potential of these methods for the analysis of human blood cell responses is demonstrated and estimates are given of the effects of total amount of exposure and time of protraction in determining the minimum white blood cell concentration observed after exposure of patients from four disease groups.

  7. Gas analysis modeling system forecast for the Energy Modeling Forum North American Natural Gas Market Study

    International Nuclear Information System (INIS)

    The Gas Analysis Modeling System is a large computer-based model for analyzing the complex US natural gas industry, including production, transportation, and consumption activities. The model was developed and first used in 1982 after the passage of the NGPA, which initiated a phased decontrol of most natural gas prices at the wellhead. The categorization of gas under the NGPA and the contractual nature of the natural gas market, which existed at the time, were primary factors in the development of the basic structure of the model. As laws and regulations concerning the natural gas market have changed, the model has evolved accordingly. Recent increases in competition in the wellhead market have also led to changes in the model. GAMS produces forecasts of natural gas production, consumption, and prices annually through 2010. It is an engineering-economic model that incorporates several different mathematical structures in order to represent the interaction of the key groups involved in the natural gas market. GAMS has separate supply and demand components that are equilibrated for each year of the forecast by means of a detailed transaction network

  8. Shallow gas cloud illumination analysis by the focal beam method

    Science.gov (United States)

    Latiff, Abdul Halim Abdul

    2016-02-01

    This research will address the illumination issue of seismic data below a shallow gas cloud, also known as shallow gas accumulation. In general, poor and distorted seismic data underneath gas zones depend on four major factors; namely the velocity of the gas zones, the depth of the target reflector, the location of the source and the receiver during seismic acquisition, and the frequency of the seismic signals. These factors will be scrutinized in detail by using the focal beam method. The focal beam method incorporates the double focusing concept in order to obtain two important attributes for illumination analysis: (i) Resolution function beam, (ii) amplitude versus ray parameter (AVP) imprint, which is obtained by transforming the modelled data into the radon domain. Both illumination attributes are then applied to a gas-affected field in the Malaysia Basin. The results show well-defined illumination beneath the shallow anomalies and provide a better representation of the subsurface.

  9. A method for calculating regional cerebral blood flow from emission computed tomography of inert gas concentrations

    DEFF Research Database (Denmark)

    Celsis, P; Goldman, T; Henriksen, L; Lassen, N A

    1981-01-01

    Emission tomography of positron or gamma emitting inert gases allows calculation of regional cerebral blood flow (rCBF) in cross-sectional slices of human brain. An algorithm is presented for rCBF calculations from a sequence of time averaged tomograms using inhaled 133Xe. The approach is designe...

  10. Comparative analysis from hydroelectric generation versus natural gas

    International Nuclear Information System (INIS)

    The aim of the work was to present a comparative analysis between hydroelectric generation and natural gas based on integrated resource planning and sustainable development. The introduced comparative analysis considers the financial aspects; the appropriated technology; and the social, environmental and political factors. The hydroelectric option it showed more advantageous than the thermoelectric. This result was independent of the enterprise scale

  11. Unlocking thin bed potential: gas identification through downhole fluid analysis

    Energy Technology Data Exchange (ETDEWEB)

    Loi, D.; Mazzoni, S.; Gigliotti, M.; Baio, C.; Borghi, M.; Baldini, D.; Italiano, F. [Schlumberger (United States)

    2011-07-01

    Thin beds have been recently proposed as an alternative to multilayer sand reservoirs for countering the decline in production from offshore gas fields. However, this approach is still not applied because of difficulties in identifying gas bearing zones. This paper presents a critical review of existing thin bed evaluation techniques and describes a successful case history in the Adriatic sea in which wireline formation testing (RFT) technology, using a dual packer string with downhole fluid analysis capabilities, including fluid density measurement, was used to distinguish gas zones from water zones. This approach gave a 100% success ratio for downhole fluid analysis stations in a tight environment and provided an effective way to acquire reservoir pressure without supercharging effects and allow the operator to confirm gas presence in several thin bed levels. Moreover, this approach also helps to improve optimization of completion techniques (FracPack and High Rate Water Pack) and saves the cost of multiple well testings, thus reducing total costs.

  12. The Use of Gas Chromatography for Biogas Analysis

    Science.gov (United States)

    Andersen, Amanda; Seeley, John; Aurandt, Jennifer

    2010-04-01

    Energy from natural gas accounts for 24 percent of energy consumed in the US. Natural gas is a robust form of energy which is rich in methane content and is low in impurities. This quality suggests that it is a very clean and safe gas; it can be used in providing heat, a source for cooking, and in powering vehicles. The downside is that it is a non-renewable resource. On the contrary, methane rich gas that is produced by the breakdown of organic material in an anaerobic environment, called biogas, is a renewable energy source. This research focuses on the gas analysis portion of the creation of the anaerobic digestion and verification laboratory where content and forensic analysis of biogas is performed. Gas Chromatography is implemented as the optimal analytical tool for quantifying the components of the biogas including methane, carbon dioxide, hydrogen sulfide and siloxanes. In addition, the problems associated with the undesirable components are discussed. Anaerobic digestion of primary sludge has consistently produced about 55 percent methane; future goals of this research include studying different substrates to increase the methane yield and decrease levels of impurities in the gas.

  13. Exergy analysis of waste emissions from gas flaring

    Directory of Open Access Journals (Sweden)

    Olawale Saheed ISMAIL

    2016-07-01

    Full Text Available Gas flaring produces a stream of waste gases at high temperature and pressure which contains carbon monoxide, Hydrogen Sulphide etc. The resultant effect of which is detrimental to our planet and, consequently, to the life of both the living and the non-living things. It’s well known that gas flaring contributes in no small measure to the global warming. Exergy analysis is applied in this work to analyze waste emissions from gas flaring so as to have a model through which impact of gas flaring can be measured. The study considers both the thermo-mechanical exergy and the chemical exergy of these gases. Relevant data on gas flaring activities in the Niger-Delta region of Nigeria between the periods of fifteen (15 years was obtained from the Nigerian National Petroleum Corporation (NNPC. A computer program (Exergy Calculator was developed based on the equations generated in the Model. Exergy associated with gas flaring activities in Nigeria between the periods of 1998 through 2012 was calculated. The results show that 1 mscf (in thousand cubic feet of flared gases generate 0.000041 MWh of energy leading to a value of 440158.607 MWh of energy for the period under review.The analysis provides important conclusions and recommendations for improving oil platforms operationsin in order to safeguard the environment, health of the populace, and maximize recovered exergy from gas flaring.

  14. Cost-benefit analysis for gas infrastructure projects

    OpenAIRE

    Keyaerts, Nico; Glachant, Jean-Michel

    2014-01-01

    QM-AI-14-003-EN-C QM-AI-14-003-EN-N • To reinvigorate the building of new gas infrastructure in Europe, the Euro­pean Union has introduced ‘projects of common interest’ (PCI) in its Energy Infrastructure Package. These PCIs will be evaluated and selected on the basis of systematic cost-benefit analysis (CBA), a method that is novel for the Euro­pean gas industry. A consistent gas-CBA method has to be designed by ENT­SOG, who published a preliminary draft method for public consultation o...

  15. Engineering analysis of biomass gasifier product gas cleaning technology

    Energy Technology Data Exchange (ETDEWEB)

    Baker, E.G.; Brown, M.D.; Moore, R.H.; Mudge, L.K.; Elliott, D.C.

    1986-08-01

    For biomass gasification to make a significant contribution to the energy picture in the next decade, emphasis must be placed on the generation of clean, pollutant-free gas products. This reports attempts to quantify levels of particulated, tars, oils, and various other pollutants generated by biomass gasifiers of all types. End uses for biomass gases and appropriate gas cleaning technologies are examined. Complete systems analysis is used to predit the performance of various gasifier/gas cleanup/end use combinations. Further research needs are identified. 128 refs., 20 figs., 19 tabs.

  16. Market Analysis for Gas Engine Technology in Algeria

    OpenAIRE

    Michaut, Stephane

    2013-01-01

    The objective of this diploma thesis is to investigate the potential of combined heat and power plants based on gas engine technology in Algeria. This market analysis has been performed in order to identify the key markets for the newly created French subsidiary of Clarke Energy Group to expand its business in North Africa. After analyzing the structure of the Algerian energy sector and the potential of each gas engine application, three key sectors were identified. For each sector, a technic...

  17. Whole blood glucose analysis based on smartphone camera module.

    Science.gov (United States)

    Devadhasan, Jasmine Pramila; Oh, Hyunhee; Choi, Cheol Soo; Kim, Sanghyo

    2015-11-01

    Complementary metal oxide semiconductor (CMOS) image sensors have received great attention for their high efficiency in biological applications. The present work describes a CMOS image sensor-based whole blood glucose monitoring system through a point-of-care (POC) approach. A simple poly-ethylene terephthalate (PET) chip was developed to carry out the enzyme kinetic reaction at various concentrations (110–586 mg∕dL) of mouse blood glucose. In this technique, assay reagent is immobilized onto amine functionalized silica (AFSiO2) nanoparticles as an electrostatic attraction in order to achieve glucose oxidation on the chip. The assay reagent immobilized AFSiO2 nanoparticles develop a semi-transparent reaction platform, which is technically a suitable chip to analyze by a camera module. The oxidized glucose then produces a green color according to the glucose concentration and is analyzed by the camera module as a photon detection technique; the photon number decreases when the glucose concentration increases. The combination of these components, the CMOS image sensor and enzyme immobilized PET film chip, constitute a compact, accurate, inexpensive, precise, digital, highly sensitive, specific, and optical glucose-sensing approach for POC diagnosis. PMID:26524683

  18. Whole blood glucose analysis based on smartphone camera module

    Science.gov (United States)

    Devadhasan, Jasmine Pramila; Oh, Hyunhee; Choi, Cheol Soo; Kim, Sanghyo

    2015-11-01

    Complementary metal oxide semiconductor (CMOS) image sensors have received great attention for their high efficiency in biological applications. The present work describes a CMOS image sensor-based whole blood glucose monitoring system through a point-of-care (POC) approach. A simple poly-ethylene terephthalate (PET) chip was developed to carry out the enzyme kinetic reaction at various concentrations (110-586 mg/dL) of mouse blood glucose. In this technique, assay reagent is immobilized onto amine functionalized silica (AFSiO2) nanoparticles as an electrostatic attraction in order to achieve glucose oxidation on the chip. The assay reagent immobilized AFSiO2 nanoparticles develop a semi-transparent reaction platform, which is technically a suitable chip to analyze by a camera module. The oxidized glucose then produces a green color according to the glucose concentration and is analyzed by the camera module as a photon detection technique; the photon number decreases when the glucose concentration increases. The combination of these components, the CMOS image sensor and enzyme immobilized PET film chip, constitute a compact, accurate, inexpensive, precise, digital, highly sensitive, specific, and optical glucose-sensing approach for POC diagnosis.

  19. Development of a gas systems analysis model (GSAM)

    Energy Technology Data Exchange (ETDEWEB)

    Godec, M.L. [IFC Resources Inc., Fairfax, VA (United States)

    1995-04-01

    The objectives of developing a Gas Systems Analysis Model (GSAM) are to create a comprehensive, non-proprietary, PC based model of domestic gas industry activity. The system is capable of assessing the impacts of various changes in the natural gas system within North America. The individual and collective impacts due to changes in technology and economic conditions are explicitly modeled in GSAM. Major gas resources are all modeled, including conventional, tight, Devonian Shale, coalbed methane, and low-quality gas sources. The modeling system asseses all key components of the gas industry, including available resources, exploration, drilling, completion, production, and processing practices, both for now and in the future. The model similarly assesses the distribution, storage, and utilization of natural gas in a dynamic market-based analytical structure. GSAM is designed to provide METC managers with a tool to project the impacts of future research, development, and demonstration (RD&D) benefits in order to determine priorities in a rapidly changing, market-driven gas industry.

  20. Maternal and fetal arterial blood gas data during general anaesthesia for caesarean delivery of preterm twin lambs.

    Science.gov (United States)

    Musk, G C; Kemp, M W

    2016-06-01

    Much remains to be understood with regards the effects of prolonged anaesthesia on maternal and fetal haemodynamics and oxygenation. With the aim of improving anaesthetic management of pregnant sheep undergoing recovery surgery under anaesthesia, paired maternal and fetal arterial blood samples were collected during caesarean delivery of twin preterm lambs to document the blood gas status of the ewe and fetus. Twenty-one Merino twin pregnant ewes at 126 (±1) days of gestation were anaesthetized for caesarean delivery of their fetuses. Arterial blood samples were collected from the radial artery of the ewe and umbilical artery of the fetus at the point of delivery. There was a significant difference between maternal PaCO2 and end-tidal CO2 and alveolar and arterial PaO2, indicating ventilation perfusion mismatch. Interestingly, the ewes were anaemic but the fetuses were not. These data underscore the need to undertake further work to determine the optimal anaesthetic regimen for twin pregnant ewes at different gestational ages in a biomedical research setting. PMID:26219550

  1. Gas migration through argillaceous sediments: soil gas analysis as an investigation tool

    International Nuclear Information System (INIS)

    Soil gas analysis is based on the measurement of gases, originating in deep crustal layers, in the soil pores. Since gases flow preferentially in channels of enhanced permeability, such as fractures and faults, the technique can provide valuable information for possible application in different fields. Review of recent activities in different areas underlain by argillaceous sediments shows that soil gas analysis may contribute to the characterization of candidate sites for the isolation of hazardous substances, including radioactive waste. 18 refs., 10 figs., 1 tab

  2. Membrane oxygenator heat exchanger failure detected by unique blood gas findings.

    Science.gov (United States)

    Hawkins, Justin L

    2014-03-01

    Failure of components integrated into the cardiopulmonary bypass circuit, although rare, can bring about catastrophic results. One of these components is the heat exchanger of the membrane oxygenator. In this compartment, unsterile water from the heater cooler device is separated from the sterile blood by stainless steel, aluminum, or by polyurethane. These areas are glued or welded to keep the two compartments separate, maintaining sterility of the blood. Although quality control testing is performed by the manufacturer at the factory level, transport presents the real possibility for damage. Because of this, each manufacturer has included in the instructions for use a testing procedure for testing the integrity of the heat exchanger component. Water is circulated through the heat exchanger before priming and a visible check is made of the oxygenator bundle to check for leaks. If none are apparent, then priming of the oxygenator is performed. In this particular case, this procedure was not useful in detecting communication between the water and blood chambers of the oxygenator. PMID:24779125

  3. Thermodynamic Analysis of Supplementary-Fired Gas Turbine Cycles

    Directory of Open Access Journals (Sweden)

    Bjørn Qvale

    2003-06-01

    Full Text Available

    This paper presents an analysis of the possibilities for improving the efficiency of an indi-rectly biomass-fired gas turbine (IBFGT by supplementary direct gas-firing. The supplementary firing may be based on natural gas, biogas or pyrolysis gas. Intuitively, supplementary firing is expected to result in a high marginal efficiency. The paper shows that depending on the application, this is not always the case.

    The interest in this cycle arises from a recent demonstration of the feasibility of a two-stage gasification process through construction of several plants. The gas from this process could be divided into two streams, one for primary and one for supplementary firing. A preliminary analysis of the ideal, recuperated Brayton cycle shows that for this cycle any supplementary firing will have a marginal efficiency of unity per extra unit of fuel. The same result is obtained for the indirectly fired gas turbine (IFGT and for the supplementary-fired IFGT. These results show that the combination of external firing and internal firing have the potential of reducing or solving some problems associated with the use of biomass both in the recuperated and the indirectly fired gas turbine: The former requires a clean, expensive fuel. The latter is limited in efficiency due to limitations in material temperature of the heat exchanger. Thus, in the case of an IBFGT, it would appear be very appropriate to use a cheap biomass or waste fuel for low temperature combustion and external firing and use natural gas at a high marginal efficiency for high temperature heating. However, it is shown that this is not the case for a simple IBFGT supplementary-fired with natural gas. The marginal efficiency of the natural gas is in this case found to be independent of temperature ratio and lower than for the recuperated gas turbine. Instead, other process changes may be considered in order to obtain a high marginal efficiency on natural gas. Two possibilities

  4. Analysis of reasons for discarding blood and blood components in a blood bank of tertiary care hospital in central India: A prospective study

    Directory of Open Access Journals (Sweden)

    Alok Kumar

    2014-01-01

    Full Text Available Background: Many modern surgical procedures could not be carried out without the use of blood. There are no substitutes for human blood. Thus, proper utilization of blood is necessary with minimal wasting. Materials and Methods: A total of 10,582 donors donated blood during the study period of 19 months in blood bank of a tertiary care hospital, central India from 1 st of November 2009 to 31 st May 2011, which were screened. Results: A total of 346 whole blood bags were discarded. Out of these 346 blood bags, 257 (74.30% were discarded because of seropositivity for transfusion transmissible infectious diseases. A total of 542 blood components were discarded against 3702 blood components prepared during the study period. Among blood components discarded, most common units were platelets. The most common cause of discarding the blood components was expiry of date due to non-utilization (87.00%. Conclusion: A properly conducted donor interview, notification of permanently deferred donors will help in discarding less number of bags from collected units. Similarly, properly implemented blood transfusion policies will also help in discarding less number of blood bags due to expiry. These discarded bags, because they are unutilized are both financially as well as socially harmful to the blood bank.

  5. Depleted uranium analysis in blood by inductively coupled plasma mass spectrometry

    Science.gov (United States)

    Todorov, T.I.; Xu, H.; Ejnik, J.W.; Mullick, F.G.; Squibb, K.; McDiarmid, M.A.; Centeno, J.A.

    2009-01-01

    In this study we report depleted uranium (DU) analysis in whole blood samples. Internal exposure to DU causes increased uranium levels as well as change in the uranium isotopic composition in blood specimen. For identification of DU exposure we used the 235U/238U ratio in blood samples, which ranges from 0.00725 for natural uranium to 0.002 for depleted uranium. Uranium quantification and isotopic composition analysis were performed by inductively coupled plasma mass spectrometry. For method validation we used eight spiked blood samples with known uranium concentrations and isotopic composition. The detection limit for quantification was determined to be 4 ng L-1 uranium in whole blood. The data reproduced within 1-5% RSD and an accuracy of 1-4%. In order to achieve a 235U/238U ratio range of 0.00698-0.00752% with 99.7% confidence limit a minimum whole blood uranium concentration of 60 ng L??1 was required. An additional 10 samples from a cohort of veterans exposed to DU in Gulf War I were analyzed with no knowledge of their medical history. The measured 235U/ 238U ratios in the blood samples were used to identify the presence or absence of DU exposure within this patient group. ?? 2009 The Royal Society of Chemistry.

  6. Bioimpedance spectroscopy as technique of hematological and biochemical analysis of blood

    Science.gov (United States)

    Malahov, M. V.; Smirnov, A. V.; Nikolaev, D. V.; Melnikov, A. A.; Vikulov, A. D.

    2010-04-01

    Bioimpedance spectroscopy may become a useful method for the express analysis and monitoring of blood parameters. The aim of this study was to identify biochemical and hematological parameters of blood that can be accurately predicted by means of bioimpedance technique. Hematological (red blood cell and white blood cell parameters) and biochemical (total proteins, albumins, fibrinogen, sodium, potassium, chloride ion concentrations in plasma) parameters were measured with a hematological analyzer and routine methods. Bioimpedance spectroscopy of the whole blood (1.5 ml) in frequency range 5-500 kHz (31 frequencies) was performed using BIA analyzer ABC-01 "Medass". Frequency relationships of resistance and reactance of the whole blood and the parameters of the Cole model were investigated. Close simple and multiple correlations of bioimpedance indices were observed only with erythrocyte parameters (Ht, Hb, RBC). Thus bioimpedance analysis of the whole blood can accurately predict red cell parameters but it is less effective for estimation of plasma biochemical and white cell parameters.

  7. Analysis of reasons for discarding blood and blood components in a blood bank of tertiary care hospital in central India: A prospective study

    OpenAIRE

    Alok Kumar; Satish Sharma,; Narayan Shyamrao Ingole; Nitin Gangane

    2014-01-01

    Background: Many modern surgical procedures could not be carried out without the use of blood. There are no substitutes for human blood. Thus, proper utilization of blood is necessary with minimal wasting. Materials and Methods: A total of 10,582 donors donated blood during the study period of 19 months in blood bank of a tertiary care hospital, central India from 1 st of November 2009 to 31 st May 2011, which were screened. Results: A total of 346 whole blood bags were discarded. Out of thes...

  8. A numerical analysis on the curved bileaflet Mechanical Heart Valve (MHV) : leaflet motion and blood flow in an elastic blood vessel

    International Nuclear Information System (INIS)

    In blood flow passing through the Mechanical Heart Valve (MHV) and elastic blood vessel, hemolysis and platelet activation causing thrombus formation can be seen owing to the shear stress in the blood. Also, fracture and deformation of leaflets can be observed depending on the shape and material properties of the leaflets which is opened and closed in a cycle. Hence, comprehensive study is needed on the hemodynamics which is associated with the motion of leaflet and elastic blood vessel in terms of fluid-structure interaction. In this paper, a numerical analysis has been performed for a three-dimensional pulsatile blood flow associated with the elastic blood vessel and curved bileaflet for multiple cycles in light of fluid-structure interaction. From this analysis fluttering phenomenon and rebound of the leaflet have been observed and recirculation and regurgitation have been found in the flow fields of the blood. Also, the pressure distribution and the radial displacement of the elastic blood vessel have been obtained. The motion of the leaflet and flow fields of the blood have shown similar tendency compared with the previous experiments carried out in other studies. The present study can contribute to the design methodology for the curved bileaflet mechanical heart valve. Furthermore, the proposed fluid-structure interaction method will be effectively used in various fields where the interaction between fluid flow and structure are involved

  9. Diastolic blood pressure and area of residence: multilevel versus ecological analysis of social inequity

    OpenAIRE

    Merlo, Juan; Östergren, Per-Olof; Hagberg, Oskar; Lindström, Martin; Lindgren, Anna; Melander, Arne; Råstam, Lennart; Berglund, Göran

    2001-01-01

    STUDY OBJECTIVES---To study geographical differences in diastolic blood pressure and the influence of the social environment (census percentage of people with low educational achievement) on individual diastolic blood pressure level, after controlling for individual age and educational achievement. To compare the results of multilevel and ecological analyses. DESIGN---Cross sectional analysis performed by multilevel linear regression modelling, with women at the first level and urban areas...

  10. Scale Space Methods for Analysis of Type 2 Diabetes Patients' Blood Glucose Values

    OpenAIRE

    Stein Olav Skrøvseth; Fred Godtliebsen

    2011-01-01

    We describe how scale space methods can be used for quantitative analysis of blood glucose concentrations from type 2 diabetes patients. Blood glucose values were recorded voluntarily by the patients over one full year as part of a self-management process, where the time and frequency of the recordings are decided by the patients. This makes a unique dataset in its extent, though with a large variation in reliability of the recordings. Scale space and frequency space techniques are suited to ...

  11. Principal-component-analysis-based estimation of blood flow velocities using optical coherence tomography intensity signals

    OpenAIRE

    Mohan, Nishant; Vakoc, Benjamin

    2011-01-01

    The intensity signal in optical coherence tomography contains information about the translational velocity of scatterers, and can be used to quantify blood flow. We apply principal component analysis to efficiently extract this information. We also study use of nonuniform temporal sampling of the intensity signal to increase the range of quantifiable flow velocities. We demonstrate this technique in simulation, phantom and in vivo blood flow measurements, and highlight its potential to enable...

  12. Importance of blood gas measurements in perinatal asphyxia and alternatives to restore the acid base balance status to improve the newborn performance

    Directory of Open Access Journals (Sweden)

    H. Orozco-Gregorio

    2007-01-01

    Full Text Available Prolonged or intermittent asphyxia in utero and during farrowing weakens piglets and renders them less capable of adaptation to extrauterine life. Piglets with lesser viability at birth have increased blood pCO2 and blood lactic acid concentrations and decreased blood pH. Moreover, the ability to thermoregulate during an acute cold stress is inversely related to umbilical blood lactate concentrations. Blood gas measurements and noninvasive estimations provide important information about oxygenation. The general goals of oxygen therapy in the neonate are to maintain adequate arterial PaO2 and SaO2, and to minimize cardiac work and the work of breathing. Arterial blood gas determinations of pCO2 provide the most accurate determinations of the adequacy of alveolar ventilation. Blood gases obtained in the immediate perinatal period can help assess perinatal asphyxia, but particular attention must be paid to the sampling site, the time of life, and the possible and proven diagnoses. The decision to obtain blood gases must be weighed by the individual clinician against the potential benefits. Current measures for restoring the acid base balance status in the newborn with perinatal asphyxia are discussed.

  13. Simultaneous blood flow and blood oxygenation measurements using a combination of diffuse speckle contrast analysis and near-infrared spectroscopy

    Science.gov (United States)

    Seong, Myeongsu; Phillips, Zephaniah; Mai, Phuong Minh; Yeo, Chaebeom; Song, Cheol; Lee, Kijoon; Kim, Jae Gwan

    2016-02-01

    A combined diffuse speckle contrast analysis (DSCA)-near-infrared spectroscopy (NIRS) system is proposed to simultaneously measure qualitative blood flow and blood oxygenation changes in human tissue. The system employs an optical switch to alternate two laser sources at two different wavelengths and a CCD camera to capture the speckle image. Therefore, an optical density can be measured from two wavelengths for NIRS measurements and a speckle contrast can be calculated for DSCA measurements. In order to validate the system, a flow phantom test and an arm occlusion protocol for arterial and venous occlusion were performed. Shorter exposure times (<1 ms) show a higher drop (between 50% and 66%) and recovery of 1/KS2 values after occlusion (approximately 150%), but longer exposure time (3 ms) shows more consistent hemodynamic changes. For four subjects, the 1/KS2 values dropped to an average of 82.1±4.0% during the occlusion period and the average recovery of 1/KS2 values after occlusion was 109.1±0.8%. There was also an approximately equivalent amplitude change in oxyhemoglobin (OHb) and deoxyhemoglobin (RHb) during arterial occlusion (max RHb=0.0085±0.0024 mM/DPF, min OHb=-0.0057±0.0044 mM/DPF). The sensitivity of the system makes it a suitable modality to observe qualitative hemodynamic trends during induced physiological changes.

  14. Linkage analysis of systolic blood pressure: a score statistic and computer implementation

    OpenAIRE

    Peng Yingwei; Wang Kai

    2003-01-01

    Abstract A genome-wide linkage analysis was conducted on systolic blood pressure using a score statistic. The randomly selected Replicate 34 of the simulated data was used. The score statistic was applied to the sibships derived from the general pedigrees. An add-on R program to GENEHUNTER was developed for this analysis and is freely available.

  15. Gas quality analysis and evaluation program for project Gasbuggy

    International Nuclear Information System (INIS)

    Experimental results of the gas quality analysis program for Project Gasbuggy through August 1969 are presented graphically, addressing the questions raised by the preshot program goals. The chemical composition and the concentrations of tritium, krypton-85, carbon-14 and argon-37, 39 are presented as a function of time and gas production from the nuclear chimney. Chemically, the presence of CO2, CO and H2 served to dilute the formation gas and caused reactions which significantly altered the gas composition at early times. The radionuclide content of the chimney gas at reentry was some 800 pCi/cm3 of which about 80% was CH3T. Lesser quantities of tritium were observed as HT, C2H5T and C3H7T. The other major contaminant was Kr85 which was present at about one-fifth the level of CH3T. Small quantities of carbon-14 and argon-39 were also identified. The only other radionuclides identified in the gas were relatively short-lived rare gases. During the production testing, about two and one-half chimney volumes of gas at formation pressure were removed. This removal, accompanied by dilution, has reduced the radionuclide concentrations to about 7% of their levels at reentry. The production characteristics of the Gasbuggy environment prevented an adequate test of the effectiveness of chimney flushing. However, the rapid drawdown concept is supported by the available data as an effective means of reducing contaminant levels. The changes in composition during production or testing are seen to be consistent with a model involving a non-uniform gas influx rate and flow distribution over the chimney region. Mixing times are estimated to be on the order of a few days, so that increasing concentrations following a sudden gas influx can be explained. (author)

  16. Greenhouse gas emission measurement and economic analysis of Iran natural gas fired power plants

    International Nuclear Information System (INIS)

    This study attempts to examine the natural gas fired power plants in Iran. The required data from natural gas fired power plants were gathered during 2008. The characteristics of thirty two gas turbine power plants and twenty steam power plants have been measured. Their emission factor values were then compared with the standards of Energy Protection Agency, Euro Union and World Bank. Emission factors of gas turbine and steam power plants show that gas turbine power plants have a better performance than steam power plants. For economic analysis, fuel consumption and environmental damages caused by the emitted pollutants are considered as cost functions; and electricity sales revenue are taken as benefit functions. All of these functions have been obtained according to the capacity factor. Total revenue functions show that gas turbine and steam power plants are economically efficient at 98.15% and 90.89% of capacity factor, respectively; this indicates that long operating years of power plants leads to reduction of optimum capacity factor. The stated method could be implemented to assess the economic status of a country’s power plants where as efficient capacity factor close to one means that power plant works in much better condition. - Highlights: • CO2 and NOx emissions of Iran natural gas fired power plants have been studied. • CO2 and NOx emission factors are compared with EPA, EU and World Bank standards. • Costs and benefit as economic functions are obtained according to capacity factor. • Maximum economic profit is obtained for gas turbine and steam power plants. • Investment in CO2 reduction is recommended instead of investment in NOx reduction

  17. Greenhouse gas and energy analysis of substitute natural gas from biomass for space heat

    International Nuclear Information System (INIS)

    In this paper, the greenhouse gas and energy balances of the production and use for space heating of substitute natural gas from biomass (bio-SNG) for space heat are analysed. These balances are compared to the use of natural gas and solid biomass as wood chips to provide the same service. The reduction of the greenhouse gas emissions (CO2-eq.) – carbon dioxide, methane and nitrous oxide – and of the fossil primary energy use is investigated in a life cycle assessment (LCA). This assessment was performed for nine systems for bio-SNG; three types of gasification technologies (O2-blown entrained flow, O2-blown circulating fluidised bed and air–steam indirect gasification) with three different types of feedstock (forest residues, miscanthus and short rotation forestry). The greenhouse gas analysis shows that forest residues using the air–steam indirect gasification technology result in the lowest greenhouse gas emissions (in CO2-eq. 32 kg MWh−1 of heat output). This combination results in 80% reduction of greenhouse gas emissions when compared to natural gas and a 29% reduction of greenhouse gases if the forest residues were converted to wood chips and combusted. The gasification technologies O2-blown entrained flow and O2-blown circulating fluidised bed gasification have higher greenhouse gas emissions that range between in CO2-eq. 41 to 75 kg MWh−1 of heat output depending on the feedstock. When comparing feedstocks in the bio-SNG systems, miscanthus had the highest greenhouse gas emissions bio-SNG systems producing in CO2-eq. 57–75 kg MWh−1 of heat output. Energy analysis shows that the total primary energy use is higher for bio-SNG systems (1.59–2.13 MWh MWh−1 of heat output) than for the reference systems (in 1.37–1.51 MWh MWh−1 of heat output). However, with bio-SNG the fossil primary energy consumption is reduced compared to natural gas. For example, fossil primary energy use is reduced by 92% when air–steam indirect gasification

  18. Quantification of myocardial blood flow using dynamic N-13 ammonia PET and factor analysis

    International Nuclear Information System (INIS)

    We evaluate the feasibility of extracting pure left ventricular blood pool and myocardial time activity curves (TACs) and of generating factor images from human dynamic N-13 ammonia PET using factor analysis. The myocardial blood flow (MBF) estimates obtained with factor analysis were compared with those obtained with the user drawn region-of-interest (ROI) method. Stress and rest N-13 ammonia cardiac PET imaging was acquired for 23 min in 5 patients with coronary artery disease using GE Advance tomography. Factor analysis generated physiological TACs and factor images using the normalized TACs from each dixel. Four steps were involved in this algorithm: (a) data preprocessing; (b) principal component analysis; (c) oblique rotation with positivity constraints; (d) factor image computation. Area under curves and MBF estimated using the two compartment N-13 ammonia model were used to validate the accuracy of the factor analysis generated physiological TACs. The MBF values obtained by factor analysis were linearly correlated with MBF obtained by the ROI method (slope = 0.84, r=0.91. Left ventricular blood pool TACs obtained by the two methods agreed well (Area under curve ratio: 1.02 (0∼1 min), 0.98 (0∼2 min), 0.86 (1∼2 min). The results of this study demonstrates that MBF can be measured accurately and noninvasively with dynamic N-13 ammonia PET imaging and factor analysis. This method is simple and accurate, and can measure MBF without blood sampling, ROI definition or spillover correction

  19. Gas-cooled reactor safety and accident analysis

    International Nuclear Information System (INIS)

    The Specialists' Meeting on Gas-Cooled Reactor Safety and Accident Analysis was convened by the International Atomic Energy Agency in Oak Ridge on the invitation of the Department of Energy in Washington, USA. The meeting was hosted by the Oak Ridge National Laboratory. The purpose of the meeting was to provide an opportunity to compare and discuss results of safety and accident analysis of gas-cooled reactors under development, construction or in operation, to review their lay-out, design, and their operational performance, and to identify areas in which additional research and development are needed. The meeting emphasized the high safety margins of gas-cooled reactors and gave particular attention to the inherent safety features of small reactor units. The meeting was subdivided into four technical sessions: Safety and Related Experience with Operating Gas-Cooled Reactors (4 papers); Risk and Safety Analysis (11 papers); Accident Analysis (9 papers); Miscellaneous Related Topics (5 papers). A separate abstract was prepared for each of these papers

  20. Using Single Drop Microextraction for Headspace Analysis with Gas Chromatography

    Science.gov (United States)

    Riccio, Daniel; Wood, Derrick C.; Miller, James M.

    2008-01-01

    Headspace (HS) gas chromatography (GC) is commonly used to analyze samples that contain non-volatiles. In 1996, a new sampling technique called single drop microextraction, SDME, was introduced, and in 2001 it was applied to HS analysis. It is a simple technique that uses equipment normally found in the undergraduate laboratory, making it ideal…

  1. In vivo analysis of physiological 3D blood flow of cerebral veins

    Energy Technology Data Exchange (ETDEWEB)

    Schuchardt, Florian; Schroeder, Laure; Baeuerle, Jochen; Harloff, Andreas [University Medical Centre, Department of Neurology, Freiburg (Germany); Anastasopoulos, Constantin [University Medical Center, Department of Neuropaediatrics and Muscle Disorders, Freiburg (Germany); University Medical Centre, Department of Neuroradiology, Freiburg (Germany); Markl, Michael [Northwestern University, Department of Radiology, Feinberg School of Medicine and McCormick School of Engineering, Chicago, IL (United States); Hennemuth, Anja; Drexl, Johann [Fraunhofer MEVIS, Bremen (Germany); Valdueza, Jose M. [Neurological Center, Segeberger Kliniken, Bad Segeberg (Germany); Mader, Irina [University Medical Centre, Department of Neuroradiology, Freiburg (Germany)

    2015-08-15

    To visualize and quantify physiological blood flow of intracranial veins in vivo using time-resolved, 3D phase-contrast MRI (4D flow MRI), and to test measurement accuracy. Fifteen healthy volunteers underwent repeated ECG-triggered 4D flow MRI (3 Tesla, 32-channel head coil). Intracranial venous blood flow was analysed using dedicated software allowing for blood flow visualization and quantification in analysis planes at the superior sagittal, straight, and transverse sinuses. MRI was evaluated for intra- and inter-observer agreement and scan-rescan reproducibility. Measurements of the transverse sinuses were compared with transcranial two-dimensional duplex ultrasound. Visualization of 3D blood flow within cerebral sinuses was feasible in 100 % and within at least one deep cerebral vein in 87 % of the volunteers. Blood flow velocity/volume increased along the superior sagittal sinus and was lower in the left compared to the right transverse sinus. Intra- and inter-observer reliability and reproducibility of blood flow velocity (mean difference 0.01/0.02/0.02 m/s) and volume (mean difference 0.0002/-0.0003/0.00003 l/s) were good to excellent. High/low velocities were more pronounced (8 % overestimation/9 % underestimation) in MRI compared to ultrasound. Four-dimensional flow MRI reliably visualizes and quantifies three-dimensional cerebral venous blood flow in vivo and is promising for studies in patients with sinus thrombosis and related diseases. (orig.)

  2. Analysis of the Energy Balance of Shale Gas Development

    Directory of Open Access Journals (Sweden)

    Hiroaki Yaritani

    2014-04-01

    Full Text Available Interest has rapidly grown in the use of unconventional resources to compensate for depletion of conventional hydrocarbon resources (“easy hydrocarbon” that are produced at relatively low cost from oil and gas fields with large proven reserves. When one wants to ensure the prospects for development of unconventional resources that are potentially vast in terms of their energy potential, it is essential to determine the quality of that energy. Here we consider the development of shale gas, an unconventional energy resource of particularly strong interest of late, through analysis of its energy return on investment (EROI, a key indicator for qualitative assessment of energy resources. We used a Monte Carlo approach for the carbon footprint of U.S. operations in shale gas development to estimate expected ranges of EROI values by incorporating parameter variability. We obtained an EROI of between 13 and 23, with a mean of approximately 17 at the start of the pipeline. When we incorporated all the costs required to bring shale gas to the consumer, the mean value of EROI drops from about 17 at the start of the pipeline to 12 when delivered to the consumer. The shale gas EROI values estimated in the present study are in the initial stage of shale gas exploitation where the quality of that resource may be considerably higher than the mean and thus the careful and continuous investigation of change in EROI is needed, especially as production moves off the initial “sweet spots”.

  3. Performance Analysis of Producer Gas Based Diesel Engine

    Directory of Open Access Journals (Sweden)

    J. P. Yadav

    2013-02-01

    Full Text Available Producer gas is one out of the alternative fuels used in internal combustion engines. Conventionally, it is made by flowing air and steam through a thick coal or coke bed which ranges in temperature from red hot to low temperature. The oxygen in air burns the carbon to CO2. This CO2 gets reduced to CO by contacting with carbon above the combustion zone. The freed oxygen combines with carbon and steam gets dissociated which introduces hydrogen. Producer gas has a high percentage of nitrogen since air is used [1]. Thus, in the present work a gasifier is designed and developed which could gasify any form of biomass. In the present work waste wood chips, bagasse, rice husk, and eucalyptus, etc are used for gasification in a fabricated updraft gasifier to produce producer gas. The producer gas obtained from the developed gasifier is sent along with air into a diesel engine with diesel as the primary fuel and the performance characteristics ie brake thermal efficiency, exhaust gas temperature and brake specific energy consumption of the engine are studied along with economic analysis with and without aid of producer gas.

  4. Exergy analysis of a gas-hydrate cool storage system

    International Nuclear Information System (INIS)

    Based on exergy analysis of charging and discharging processes in a gas-hydrate cool storage system, the formulas for exergy efficiency at the sensible heat transfer stage and the phase change stage corresponding to gas-hydrate charging and discharging processes are obtained. Furthermore, the overall exergy efficiency expressions of charging, discharging processes and the thermodynamic cycle of the gas-hydrate cool storage system are obtained. By using the above expressions, the effects of number of transfer units, the inlet temperatures of the cooling medium and the heating medium on exergy efficiencies of the gas-hydrate cool storage system are emphatically analyzed. The research results can be directly used to evaluate the performance of gas-hydrate cool storage systems and design more efficient energy systems by reducing the sources of inefficiency in gas-hydrate cool storage systems. - Highlights: • Formulas for exergy efficiency at four stages are obtained. • Exergy efficiency expressions of two processes and one cycle are obtained. • Three mainly influencing factors on exergy efficiencies are analyzed. • With increasing the inlet temperature of cooling medium, exergy efficiency increases. • With decreasing the inlet temperature of heating medium, exergy efficiency increases

  5. Effects of Breath Training Pattern "End-Inspiratory Pause" on Respiratory Mechanics and Arterial Blood Gas of Patients with COPD

    Institute of Scientific and Technical Information of China (English)

    梁永杰; 蔡映云

    2002-01-01

    Objective:In order to explore the mechanism of Chinese traditional breath training, theeffects of end-inspiratory pause breathing (EIPB) on the respiratory mechanics and arterial blood gas werestudied in patients with chronic obstructive pulmonary disease (COPD). Methods: Ten patients in steadystage participating in the study had a breath training of regulating the respiration rhythm as to having apause between the deep and slow inspiration and the slow expiration. Effect of the training was observed byvisual feedback from the screen of the respiratory inductive plethysmograph. The dynamic change of par-tial pressure of oxygen saturation in blood (SpO2) was recorded with sphygmo-oximeter, the pulmonarymechanics and EIPB were determined with spirometer, and the data of arterial blood gases in tranquilizedbreathing and EIPB were analysed. Results: After EIPB training, SpO2 increased progressively, PaO2 in-creased and PaCO2 decreased, and the PaO2 increment was greater than the PaCO2 decrement. Further-more, the tidal volume increased and the frequency of respiration decreased significantly, both inspirationtime and expiration time were prolonged. There was no significant change in both mean inspiration flowrate (VT/Ti) and expiration flow rate (VT/Te). The baselines in spirogram during EIPB training had noraise. Conclusion: EIPB could decrease the ratio of the dead space and tidal volume (VD/VT), cause in-crease of PaO2 more than the decrease of PaCO2, suggesting that this training could improve both the func-tion of ventilation and gaseous exchange in the lung. EIPB training might be a breathing training patternfor rehabilitation of patients with COPD.

  6. Blood Warming and Hemolysis: A Systematic Review With Meta-Analysis.

    Science.gov (United States)

    Poder, Thomas G; Nonkani, Wendyam G; Tsakeu Leponkouo, Élyonore

    2015-07-01

    The use of fluid warmers during blood transfusion is recommended to avoid inducing hypothermia and its harmful effects. Fluid warmers offered by manufacturers can reach temperatures of 43°C. However, the recommendations of national regulatory organizations do not clearly indicate the maximum heating temperature in relation to the risk of hemolysis. To fill this gap, we conducted a systematic review of the literature with meta-analysis. To match clinical practice, this review was limited to fluid warmers that used contact heating; thus, studies that used radiofrequency or microwave heating were excluded. Twenty-four observational studies were included, 17 of which were the subject of a meta-analysis. A preliminary descriptive analysis indicated that multiple factors can influence the level of hemolysis during blood heating with a liquid warmer, including blood age, anticoagulant type, duration of exposure to heat, stirring the blood during heating, and various elements of the circuit through which blood flows (eg, type of infusion pump with pressure and flow, type of microfilter, and type of tubing). Moreover, the duration between sampling and hemolysis assay was a source of heterogeneity among studies, as were the initial free hemoglobin levels in the various experiments. In general, the increase generated by each of these factors other than temperature appears to have been limited except for blood age, which is an important parameter of hemolysis, the length of exposure to heat, and, in some studies, the type of infusion pump used. Regarding the meta-analysis, at temperatures at or less than 43°C and even up to 45-46°C, it appears that blood heating is safe and causes hemolysis only in clinically negligible proportions. PMID:25840802

  7. Combined blood/tissue analysis for cancer biomarker discovery: application to renal cell carcinoma.

    Science.gov (United States)

    Johann, Donald J; Wei, Bih-Rong; Prieto, DaRue A; Chan, King C; Ye, Xiaying; Valera, Vladimir A; Simpson, R Mark; Rudnick, Paul A; Xiao, Zhen; Issaq, Haleem J; Linehan, W Marston; Stein, Stephen E; Veenstra, Timothy D; Blonder, Josip

    2010-03-01

    A method that relies on subtractive tissue-directed shot-gun proteomics to identify tumor proteins in the blood of a patient newly diagnosed with cancer is described. To avoid analytical and statistical biases caused by physiologic variability of protein expression in the human population, this method was applied on clinical specimens obtained from a single patient diagnosed with nonmetastatic renal cell carcinoma (RCC). The proteomes extracted from tumor, normal adjacent tissue and preoperative plasma were analyzed using 2D-liquid chromatography-mass spectrometry (LC-MS). The lists of identified proteins were filtered to discover proteins that (i) were found in the tumor but not normal tissue, (ii) were identified in matching plasma, and (iii) whose spectral count was higher in tumor tissue than plasma. These filtering criteria resulted in identification of eight tumor proteins in the blood. Subsequent Western-blot analysis confirmed the presence of cadherin-5, cadherin-11, DEAD-box protein-23, and pyruvate kinase in the blood of the patient in the study as well as in the blood of four other patients diagnosed with RCC. These results demonstrate the utility of a combined blood/tissue analysis strategy that permits the detection of tumor proteins in the blood of a patient diagnosed with RCC. PMID:20121140

  8. DISTRIBUTION OF CLASSICAL ABO BLOOD GROUPS AMONG TYPE 2 DIABETES MELLITUS PATIENTS : AN ANALYSIS

    Directory of Open Access Journals (Sweden)

    Rama Devi

    2015-04-01

    Full Text Available BACKGROUND: At present Diabetes Mellitus is a global phenomenon with the disease topping the list, comprising of about 32 million cases , India is in the forefront with 30% of the cases . The disease affects multiple organs and is a leading cause of much morbidity and mortality. Since it is a multi - factorial disease a major step would be to identify different associated factors, for an early diagnosis and prompt treatment. The ABO blood groups are often associated with several diseases, with one blood group more often seen with the patients of a particular disease. Our study will help to determine the frequency and distribution of blood groups in correlation with Diabetes Mellitus. MATERIAL & METHODS: This study was conducted in the Gandhi Medical College, Secunderabad, during a two year period. A random study involving every third diabetic patient was chosen and their blood group was determined. A total of 3 00 patients were selected with 150 male and 150 female patients. Another 300 volunteers who were not diabetics were chosen as controls and their blood groups were also determined. A pro - forma was given to both diabetics and controls which included the following variables : 1 . Demographic data 2. Blood grouping 3. Fasting and post prandial blood sugar. Following this, blood groups of both cohorts and controls were determined by antigen antibody agglutination method. Data analysis was do ne after data was entered into excel sheet and double checked for errors using SPSS Software RESULTS: Our a nalysis showed that O group was significantly more among diabetic patients when all patients were compared to control . ² there was a preponderance of blood group O among female diabetics and B among male diabetics. CONCLUSION: ABO blood groups have been determined in 300 diabetic patients and compared with the controls comprising of a series of 300 voluntary blood donors. When the results were analysed on the basis of sex, there was preponderance

  9. Buffering blood pressure fluctuations by respiratory sinus arrhythmia may in fact enhance them: a theoretical analysis

    CERN Document Server

    Buchner, Teodor; Gielerak, Grzegorz

    2010-01-01

    Using a three-compartment model of blood pressure dynamics, we analyze theoretically the short term cardiovascular variability: how the respiratory-related blood pressure fluctuations are buffered by appropriate heart rate changes: i.e. the respiratory sinus arrhythmia. The buffering is shown to be crucially dependent on the time delay between the stimulus (such as e.g. the inspiration onset) and the application of the control (the moment in time when the efferent response is delivered to the heart). This theoretical analysis shows that the buffering mechanism is effective only in the upright position of the body. It explains a paradoxical effect of enhancement of the blood pressure fluctuations by an ineffective control. Such a phenomenon was observed experimentally. Using the basis of the model, we discuss the blood pressure variability and heart rate variability under such clinical conditions as the states of expressed adrenergic drive and the tilt-test during the parasympathetic blockade or fixed rate atr...

  10. Analysis of gas turbine systems for sustainable energy conversion

    Energy Technology Data Exchange (ETDEWEB)

    Anheden, Marie

    2000-02-01

    Increased energy demands and fear of global warming due to the emission of greenhouse gases call for development of new efficient power generation systems with low or no carbon dioxide (CO{sub 2}) emissions. In this thesis, two different gas turbine power generation systems, which are designed with these issues in mind, are theoretically investigated and analyzed. In the first gas turbine system, the fuel is combusted using a metal oxide as an oxidant instead of oxygen in the air. This process is known as Chemical Looping Combustion (CLC). CLC is claimed to decrease combustion exergy destruction and increase the power generation efficiency. Another advantage is the possibility to separate CO{sub 2} without a costly and energy demanding gas separation process. The system analysis presented includes computer-based simulations of CLC gas turbine systems with different metal oxides as oxygen carriers and different fuels. An exergy analysis comparing the exergy destruction of the gas turbine system with CLC and conventional combustion is also presented. The results show that it is theoretically possible to increase the power generation efficiency of a simple gas turbine system by introducing CLC. A combined gas/steam turbine cycle system with CLC is, however, estimated to reach a similar efficiency as the conventional combined cycle system. If the benefit of easy and energy-efficient CO{sub 2} separation is accounted for, a CLC combined cycle system has a potential to be favorable compared to a combined cycle system with CO{sub 2} separation. In the second investigation, a solid, CO{sub 2}-neutral biomass fuel is used in a small-scale externally fired gas turbine system for cogeneration of power and district heating. Both open and closed gas turbines with different working fluids are simulated and analyzed regarding thermodynamic performance, equipment size, and economics. The results show that it is possible to reach high power generation efficiency and total (power

  11. Numerical analysis and experiments on laminar gas jets discharged into stagnant gas of different density

    International Nuclear Information System (INIS)

    In the pipe rupture accident of a High Temperature Gas-Cooled Reactor, the atmospheric air breaks into the pressure vessel by the buoyancy-driven exchange flow or the natural convection flow in the coaxial tube, and it causes corrosion of the graphite structures. To prevent this phenomenon, injection of inert gas is very effective. The objective of this study is to investigate numerically and experimentally the behavior of fluid flow and mass transfer of laminar gas jets discharged into stagnant air. The authors have developed a code, in which a mass diffusion equation solver is incorporated, based on the SIMPLEST algorithm. By using this code, they have analyzed the transient and steady behavior of gas jets. Experimentally they have measured the velocity distribution of jets by the LDV system and compared the results with those from numerical calculations. The transient analyses show that there exists a vortex ring around the jet and the maximum value of its acceleration is correlated with the densimetric Froude number. The discharged gas is repelled along the radial direction while flooding in the axial direction. In the steady states, they succeeded in generalizing the condition on which the discharged gas at the centerline is accelerated by the gravity with the use of the densimetric Froude number. The half radius of the mass fraction of the discharged gas varies along the axial direction and has a minimum value at downstream of the outlet. The distances between the outlet of jets and the points where the half radii become minimum are related to the densimetric Froude number. By the LDV experiments, they have got the exact velocity fields which support the results of numerical analysis

  12. Automotive gasoline quality analysis by gas chromatography: study of adulteration

    Energy Technology Data Exchange (ETDEWEB)

    Moreira, L.S.; Azevedo, D.A. [Dept. de Quimica Organica, Univ. Federal do Rio de Janeiro, Ilha do Fundao, Rio de Janeiro, RJ (Brazil); d' Avila, L.A. [Dept. de Processos Organicos, Univ. Federal do Rio de Janeiro, Ilha do Fundao, Rio de Janeiro, RJ (Brazil)

    2003-10-01

    The addition of organic solvents (light aliphatic, heavy aliphatic and aromatic hydrocarbons) in Brazilian gasoline is unfortunately very frequent, and this illicit practice impares gasoline quality. Gas chromatography (GC) and gas chromatography coupled to mass spectrometry (GC-MS) analyses can be used as a procedure to improve the detection of adulterated gasoline. The results showed that adulterated samples and also the type of organic solvent used in adulteration can be detected by comparison of chromatographic profiles (standard samples versus adulterated samples). However, a single GC analysis can detect an adulterated gasoline, and so decrease the number of adulterated samples approved as presenting good quality. (orig.)

  13. GC-MS identification of MIC trimer: a constituent of tank residue in preserved autopsy blood of Bhopal gas victims.

    Science.gov (United States)

    Chandra, H; Rao, G J; Saraf, A K; Sharma, V K; Jadhav, R K; Sriramachari, S

    1991-10-01

    Based on the external and internal findings of Bhopal gas disaster victims, it was apparent that the gases and particulate matter came out as an aerosol. This was possibly the pyrolysed, reformulated, reconjugated suspension of constituents of the tank E-610 of Union Carbide India Limited, Bhopal, while it was claimed to be methyl isocyanate (MIC) only. It was postulated by the manufacturer of MIC, that the material inhaled by the victims of the Bhopal gas disaster does not cross the lung barrier (UCC press conference on 14th December 1984). It was observed that the more the victims ran, the more aerosol they inhaled and the fatalities were observed in such victims. The tissues, which were preserved in the deep freeze, were randomly selected and analysed by GC coupled with MS (ITD) Finnigan MAT, UK. 14 out of 34 autopsy cases showed MIC trimer peak in extracts of blood. This was one of the constituents of the aerosol and was also located in the tank residue, thereby proving that the trimer had passed the lung barrier. PMID:1795611

  14. OFFSITE RADIOLOGICAL CONSEQUENCE ANALYSIS FOR THE BOUNDING FLAMMABLE GAS ACCIDENT

    International Nuclear Information System (INIS)

    This document quantifies the offsite radiological consequences of the bounding flammable gas accident for comparison with the 25 rem Evaluation Guideline established in DOE-STD-3009, Appendix A. The bounding flammable gas accident is a detonation in a SST. The calculation applies reasonably conservative input parameters in accordance with guidance in DOE-STD-3009, Appendix A. The purpose of this analysis is to calculate the offsite radiological consequence of the bounding flammable gas accident. DOE-STD-3009-94, ''Preparation Guide for US. Department of Energy Nonreactor Nuclear Facility Documented Safety Analyses'', requires the formal quantification of a limited subset of accidents representing a complete set of bounding conditions. The results of these analyses are then evaluated to determine if they challenge the DOE-STD-3009-94, Appendix A, ''Evaluation Guideline,'' of 25 rem total effective dose equivalent in order to identify and evaluate safety-class structures, systems, and components. The bounding flammable gas accident is a detonation in a single-shell tank (SST). A detonation versus a deflagration was selected for analysis because the faster flame speed of a detonation can potentially result in a larger release of respirable material. A detonation in an SST versus a double-shell tank (DST) was selected as the bounding accident because the estimated respirable release masses are the same and because the doses per unit quantity of waste inhaled are greater for SSTs than for DSTs. Appendix A contains a DST analysis for comparison purposes

  15. RNA/DNA co-analysis from blood stains--Results of a second collaborative EDNAP exercise

    DEFF Research Database (Denmark)

    Haas, C.; Hanson, E.; Anjos, M.J.;

    2012-01-01

    A second collaborative exercise on RNA/DNA co-analysis for body fluid identification and STR profiling was organized by the European DNA Profiling Group (EDNAP). Six human blood stains, two blood dilution series (5-0.001 [mu]l blood) and, optionally, bona fide or mock casework samples of human or...

  16. Multiple-injection high-throughput gas chromatography analysis.

    Science.gov (United States)

    Schafer, Wes; Wang, Heather; Welch, Christopher J

    2016-08-01

    Multiple-injection techniques have been shown to be a simple way to perform high-throughput analysis where the entire experiment resides in a single chromatogram, simplifying the data analysis and interpretation. In this study, multiple-injection techniques are applied to gas chromatography with flame ionization detection and mass detection to significantly increase sample throughput. The unique issues of implementing a traditional "Fast" injection mode of multiple-injection techniques with gas chromatography and mass spectrometry are discussed. Stacked injections are also discussed as means to increase the throughput of longer methods where mass detection is unable to distinguish between analytes of the same mass and longer retentions are required to resolve components of interest. Multiple-injection techniques are shown to increase instrument throughput by up to 70% and to simplify data analysis, allowing hits in multiple parallel experiments to be identified easily. PMID:27292909

  17. Integrated analysis of halogenated organic pollutants in sub-millilitre volumes of venous and umbilical cord blood sera

    Energy Technology Data Exchange (ETDEWEB)

    Grimalt, Joan O.; Carrizo, Daniel; Otero, Raquel; Vizcaino, Esther [Institute of Environmental Assessment and Water Research (IDAeA-CSIC), Department of Environmental Chemistry, Barcelona, Catalonia (Spain); Howsam, Mike [Universite de Lille 2, Centre Universitaire de Mesure et d' Analyse, Faculte de Pharmacie, Lille (France); Rodrigues de Marchi, Mary Rosa [Institute of Chemistry UNESP, Department of Analytical Chemistry, Araraquara, SP (Brazil)

    2010-03-15

    A rapid, robust and economical method for the analysis of persistent halogenated organic compounds in small volumes of human serum and umbilical cord blood is described. The pollutants studied cover a broad range of molecules of contemporary epidemiological and legislative concern, including polychlorobiphenyls (PCBs), polychlorobenzenes (CBs), hexachlorocyclohexanes (HCHs), DDTs, polychlorostyrenes (PCSs) and polybromodiphenyl ethers (PBDEs). Extraction and clean-up with n-hexane and concentrated sulphuric acid was followed with analysis by gas chromatography coupled to electron capture (GC-ECD) and GC coupled to negative ion chemical ionisation mass spectrometry (GC-NICI-MS). The advantages of this method rest in the broad range of analytes and its simplicity and robustness, while the use of concentrated sulphuric acid extraction/clean-up destroys viruses that may be present in the samples. Small volumes of reference serum between 50 and 1000{mu}L were extracted and the limits of detection/quantification and repeatability were determined. Recoveries of spiked compounds for the extraction of small volumes ({>=}300 {mu}L) of the spiked reference serum were between 90% and 120%. The coefficients of variation of repeatability ranged from 0.1-14%, depending on the compound. Samples of 4-year-old serum and umbilical cord blood (n=73 and 40, respectively) from a population inhabiting a village near a chloro-alkali plant were screened for the above-mentioned halogenated pollutants using this method and the results are briefly described. (orig.)

  18. Effects of regulation mode of cabin gas on arterial blood gas of mariners during a prolonged voyage in a nuclear submarine

    Directory of Open Access Journals (Sweden)

    Xiao-feng LIU

    2015-04-01

    Full Text Available Objective To study the effect of different regulation modes of the air in cabin on the arterial blood gas of mariners during a prolonged voyage in a nuclear submarine. Methods During three long distance voyages of the same nuclear submarine, the same air-regeneration device was adopted. According to the different doses and percentages of the oxygen-lithium hydroxide absorbers, the mariners of three voyages were divided by sequence of voyages into control group (C, observation group 1 (A, and observation group 2 (B. The change in arterial blood PaO2 and PaCO2 of mariners in the three groups were detected on the third day of surface navigation (T1, 10th day (T2, 12nd day (T3, 13th day (T4 of submarine navigation, and the day before returning (T5. Result There was no difference between the three groups in T1 and T2 (P>0.05. There was a significant difference in PaO2 and PaCO2 between the two observation groups and the control group on T3, T4 and T5 (P<0.05. Conclusions Different amount and percentage of the oxygenlithium hydroxide showed an influence on PaO2 and PaCO2 of the mariners. Optimal amount and percentage of the oxygen-lithium hydroxide is very important in keeping normal physiological status of mariners in a nuclear submarine. DOI: 10.11855/j.issn.0577-7402.2015.03.14

  19. Exergy analysis of gas turbine with air bottoming cycle

    International Nuclear Information System (INIS)

    In this paper, the exergy analysis of a conventional gas turbine and a gas turbine with air bottoming cycle (ABC) is presented in order to study the important parameters involved in improving the performance characteristics of the ABC based on the Second Law of thermodynamics. In this study, work output, specific fuel consumption (SFC) and the exergy destruction of the components are investigated using a computer model. The variations of the ABC cycle exergy parameters are comprehensively discussed and compared with those of the simple gas turbine. The results indicate that the amount of the exhaust exergy recovery in different operating conditions varies between 8.6 and 14.1% of the fuel exergy, while the exergy destruction due to the extra components in the ABC makes up only 4.7–7.4% of the fuel exergy. This is the reason why the SFC of the ABC is averagely 13.3% less and the specific work 15.4% more than those of the simple gas turbine. The results also reveal that in the ABC cycle, at a small value of pressure ratio, a higher specific work with lower SFC can be achieved in comparison with those of the simple gas turbine. - Highlights: • Exhaust exergy recovery in ABC gas turbine varies with 8.6–14.1% of the fuel exergy. • Irreversibility of the extra devices in ABC makes up 4.7–7.4% of the fuel exergy. • SFC in ABC is poor due to exergy recovery more than extra devices irreversibility. • At the same TIT and Rc, specific work in the ABC is more than simple gas turbine. • The recuperator has the largest contribution in the irreversibility of the ABC

  20. THE DETERMINATION OF CORRELATION LINKAGES BETWEEN LEVEL OF REACTIVE OXYGEN SPECIES, CONTENTS OF NEUTROPHILES AND BLOOD GAS COMPOSITION IN EXPERIMENTAL ACUTE LUNG INJURY.

    Science.gov (United States)

    Marushchak, M; Krynytska, I; Petrenko, N; Klishch, I

    2016-04-01

    Acute lung injury (ALI) remains a major cause of acute respiratory failure and death of patients. Despite the achievements at the current stage in treatment, morbidity and mortality of ALI remain high. However, a deeper understanding of the pathogenetic links of ALI, identifying of the predictors that positively or negatively influence on the course of the syndrome, the correlation between some pathogenetic mechanisms will improve therapeutic strategies for patients with ALI, which makes the actuality of this study. The aim of the research was to detect additional pathogenetic mechanisms of the acute lung injury development in rats based on a comparative analysis of the correlations between the level of reactive oxygen species in blood and bronchoalveolar lavage, contents of neutrophils and blood gas composition. The experiments were performed on 54 white nonlinear mature male rats 200-220g in weight. The animals were divided into 5 groups: the 1st - control group (n=6), the 2nd - animals affected by hydrochloric acid for 2 hours (n=12), the 3rd - animals affected by hydrochloric acid for 6 hours (n=12), the 4th - animals affected by hydrochloric acid for 12 hours (n=12), the 5th - animals affected by hydrochloric acid for 24 hours (n=12). Correlation analysis was performed between all the studied indices. Coefficient of linear correlation (r) and its fidelity (p) was calculated that was accordingly denoted in the tables (correlation matrices). The correlation coefficient was significant at palveoli. On this background non-specific inflammatory reaction is developed at lung microvessels level with violation of lung homeostasis, which is iniciated by neutrophils' activation, which are producing ROS. PMID:27249444

  1. Gas chromatographic isolation technique for compound-specific radiocarbon analysis

    International Nuclear Information System (INIS)

    Full text: We present here a gas chromatographic isolation technique for the compound-specific radiocarbon analysis of biomarkers from the marine sediments. The biomarkers of fatty acids, hydrocarbon and sterols were isolated with enough amount for radiocarbon analysis using a preparative capillary gas chromatograph (PCGC) system. The PCGC systems used here is composed of an HP 6890 GC with FID, a cooled injection system (CIS, Gerstel, Germany), a zero-dead-volume effluent splitter, and a cryogenic preparative collection device (PFC, Gerstel). For AMS analysis, we need to separate and recover sufficient quantity of target individual compounds (>50 μgC). Yields of target compounds from C14 n-alkanes to C40 to C30 n-alkanes and approximately that of 80% for higher molecular weights compounds more than C30 n-alkanes. Compound specific radiocarbon analysis of organic compounds, as well as compound-specific stable isotope analysis, provide valuable information on the origins and carbon cycling in marine system. Above PCGC conditions, we applied compound-specific radiocarbon analysis to the marine sediments from western north Pacific, which showed the possibility of a useful chronology tool for estimating the age of sediment using organic matter in paleoceanographic study, in the area where enough amounts of planktonic foraminifera for radiocarbon analysis by accelerator mass spectrometry (AMS) are difficult to obtain due to dissolution of calcium carbonate. (author)

  2. Rice husk combustion evolved gas analysis experiments and modelling

    International Nuclear Information System (INIS)

    Rice husk is a major agricultural waste which could be a major source of fuel for boilers and furnaces if its calorific value could be realized efficiently. The oxidation kinetics of rice husks combustion were investigated using an evolved gas analysis technique. Rice husk samples were heated from 100 °C to 500 °C at a constant rate inside a small pressurised reactor. An oxygen-containing gas was passed through the reactor at a controlled flow rate and the evolved gas was continually analysed for its oxygen, carbon monoxide and carbon dioxide contents after moisture had been removed. A model for the oxidation of the rice husks samples is proposed that considers that the many simultaneous and competing oxidation reactions may be adequately represented by grouping them into three overlapping and competing reaction regimes in which CO2, CO and H2O are the only reaction products. The activation energies, and peak oxygen consumption temperatures were all found to be linear functions of the oxygen partial pressure in the reactor. Increasing the oxygen partial pressure decreased the temperatures at which peak oxygen consumption occurred. The total system pressure had no effect on the combustion behaviour other than through the oxygen partial pressure. At a heating rate of 80 K h−1 and a system pressure of 500 kPa values for E/R for the low temperature, medium temperature and high temperature oxidation reactions are 14.7, 19.2 and 17.4 respectively. - Highlights: • Oxidation kinetics of rice husk waste investigated using evolved gas analysis. • Proposed kinetics model assumes three competing and overlapping reactions occur. • Three oxidation reaction model fits evolved gas analysis well. • Activation energies of reactions are linear functions of O2 partial pressure. • O2 consumption peak temperatures decrease with increasing O2 partial pressure

  3. Effects of thoracic explosive injury on blood gas and acid base balance in rabbits at high altitude%高原家兔胸部爆炸伤对血气及酸碱平衡的影响

    Institute of Scientific and Technical Information of China (English)

    陈忠东; 李素芝; 王洪亚; 吴前进; 肖嘉芳; 易映红

    2011-01-01

    Objective To study the changes of arterial blood gas and acid base balance in rabbits suffered from thoracic explosive injury at high altitude. Methods 24 rabbits were randomly divided into high - altitude injured group ( group A ), highaltitude control group ( group B ) and plain injured group ( group C ). In group A and C, a detonator was placed above the 5th right intercostal space of rabbit and exploded to cause the thoracic injury. In group B, animals were anesthetized and cannulated without thoracic injury. Blood samples were respectively collected before injury and at 1,3,6 h after injury for arterial blood gas analysis.Results After injury,each injured group showed persistent metabolic acidosis and lower blood gas parameters than those before injury ( P < 0.05 or P < 0.01 ). There were significant differences in each blood gas parameter between group A and C ( P < 0.05 or P <0.01 ). Conclusion Decreased blood gas parameters and persistent metabolic acidosis are the most characteristic changes in rabbits suffered from thoracic explosive injury at high altitude. These changes are of significant value in the early treatment of such injury.%目的 研究高原家兔胸部爆炸伤后动脉血气分析及酸碱平衡的变化特点.方法 将家兔随机分为高原致伤组、高原对照组和平原致伤组,分别于伤前和伤后1、3、6 h采集动脉血进行血气分析.结果 伤后各致伤组均表现为持续性的代谢性酸中毒,与伤前比较血气指标值明显下降(P<0.05或P<0.01),伤后各时点高原致伤组与平原致伤组血气指标比较均有显著差异(P<0.05或P<0.01).结论 伤后高原致伤组的血气指标降低以及持续性代谢性酸中毒是高原胸部爆炸伤的最主要特征性改变,对于及早救治具有重要意义.

  4. Brazilian gas network computational model for reliability analysis

    Energy Technology Data Exchange (ETDEWEB)

    Carvalho, Thomaz; Bilhim, Thiago; Ferreira, Gustavo P. D.; Pires, Luis F. G. [Dept. Eng. Mecanica, PUC-Rio (Brazil); Faertes, Denise; Saker, Leonardo [PETROBRAS Gas and Energia (Brazil)

    2010-07-01

    Pipeline thermo-hydraulic simulation is useful to support operation, design development and reliability analysis. PETROBRAS carried reliability programs in the last years. These studies are developed to evaluate gas chain security of supply, pointing out vulnerable points and proposing optimization measures to adopt. Previously, the Brazilian gas network could be modeled using sub-networks because of the physical separation between the Northeast and the Southeast networks, but in 2010 the new GASCAC pipeline will start up and change this. The new simulation models will have to handle this new configuration. The simulations developed by the Pontifice Catholic University of Rio de Janeiro deal with steady state and transient scenarios provided by a PETROBRAS group of experts. This paper discusses the alternatives and strategies used in the thermo-hydraulic simulation of the Brazilian gas pipeline network and analyses the advantages and disadvantages of each approach and the option used to meet the demands of the reliability analysis of the PETROBRAS gas reliability management sector.

  5. Fatty acid profiling of raw human plasma and whole blood using direct thermal desorption combined with gas chromatography-mass spectrometry

    NARCIS (Netherlands)

    Akoto, Lawrence; Vreuls, Rene J. J.; Irth, Hubertus; Pel, Roel; Stellaard, Frans

    2008-01-01

    Gas chromatography (GC) has in recent times become an important tool for the fatty acid profiling of human blood and plasma. An at-line procedure used in the fatty acid profiling of whole/intact aquatic micro-organisms without any sample preparation was adapted for this work. A direct thermal desorp

  6. Fatty acid profiling of raw human plasma and whole blood using direct thermal desorption combined with gas chromatography–mass spectrometry

    NARCIS (Netherlands)

    Akoto, L.; Vreuls, R.J.J.; Irth, H.; Pel, R.; Stellaard, F.

    2008-01-01

    Gas chromatography (GC) has in recent times become an important tool for the fatty acid profiling of human blood and plasma. An at-line procedure used in the fatty acid profiling of whole/intact aquatic micro-organisms without any sample preparation was adapted for this work. A direct thermal desorp

  7. Cinnamon intake lowers fasting blood glucose: an updated meta-analysis

    Science.gov (United States)

    OBJECTIVE – To determine if meta-analysis of recent clinical studies of cinnamon intake by people with Type II diabetes and/or prediabetes resulted in significant changes in fasting blood glucose. RESEARCH DESIGN AND METHODS -- Published clinical studies were identified using a literature search (P...

  8. [Characterization of aroma active compounds in blood orange juice by solid phase microextraction and gas chromatography-mass spectrometry-olfactometry].

    Science.gov (United States)

    Qiao, Yu; Xie, Bijun; Zhang, Yan; Zhang, Yun; Pan, Siyi

    2008-07-01

    Volatile compounds of fresh blood orange juice were analyzed by solid phase microextraction and gas chromatography-mass spectrometry (SPME-GC-MS) and the aroma active compounds were identified by olfactometry. The volatile compounds were extracted by headspace solid phase microextraction (HS-SPME) using a divinylbenzene/carboxen/polydimethylsiloxane (DVB/CAR/PDMS) fiber for 40 min at 40 degrees C. The analysis was carried out using an HP 6890N GC equipped with an HP-5 column (30 m x 0.25 mm x 0.25 microm ) directly connected to an HP 5975 series mass selective detector and a sniffing port (ODP2, Gerstel) using helium as carrier gas. Compound identifications were made by the comparison of the mass spectra, retention times, retention indices (I(R)) and odor of the volatile components in the extracts with those of the corresponding reference standards. Forty-six compounds were identified by GC-MS and I(R). The major components of the juice were limonene (86.36%), linalool (3.69%), beta-myrcene (1.79%), octanal (1.32%) and valencene (1.27%). GC-MS-olfactometry analysis was performed to determine 34 compounds with aroma activity, of which 23 compounds were identified. The major contributors to orange juice aroma activity are ethyl butanoate, octanal, gamma-terpinene, 4-acetyl-1-methyleyclohexene, decanal, (-)-carvone, geranyl acetate, valencene. These compounds of strong aroma intensity represent 7.22% of the total volatile compounds. Other four unknown compounds (I(R), <800; I(R) = 1020, 1143, 1169, separately) are also the major contributors to the overall aroma. PMID:18959252

  9. Effect of Grape Polyphenols on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials

    OpenAIRE

    Shao-Hua Li; Peng Zhao; Hong-Bo Tian; Liang-Hua Chen; Lian-Qun Cui

    2015-01-01

    Background The effect of grape polyphenols on blood pressure remains unclear, which we aimed to address via a meta-analysis study. Methods We conducted study trial searches in PubMed, Embase, and the Cochrane Library databases. Summary estimates of weighted mean differences and 95% confidence intervals were obtained by using fixed-effects models. Subgroup analyses were performed to identify the source of heterogeneity. The protocol details of our meta-analysis have been submitted to the inter...

  10. Analysis of catalytic gas products using electron energy-loss spectroscopy and residual gas analysis for operando transmission electron microscopy.

    Science.gov (United States)

    Miller, Benjamin K; Crozier, Peter A

    2014-06-01

    Operando transmission electron microscopy (TEM) of catalytic reactions requires that the gas composition inside the TEM be known during the in situ reaction. Two techniques for measuring gas composition inside the environmental TEM are described and compared here. First, electron energy-loss spectroscopy, both in the low-loss and core-loss regions of the spectrum was utilized. The data were quantified using a linear combination of reference spectra from individual gasses to fit a mixture spectrum. Mass spectrometry using a residual gas analyzer was also used to quantify the gas inside the environmental cell. Both electron energy-loss spectroscopy and residual gas analysis were applied simultaneously to a known 50/50 mixture of CO and CO2, so the results from the two techniques could be compared and evaluated. An operando TEM experiment was performed using a Ru catalyst supported on silica spheres and loaded into the TEM on a specially developed porous pellet TEM sample. Both techniques were used to monitor the conversion of CO to CO2 over the catalyst, while simultaneous atomic resolution imaging of the catalyst was performed. PMID:24815065

  11. Availability Analysis of Gas Turbines Used in Power Plants

    Directory of Open Access Journals (Sweden)

    Gilberto Francisco Martha de Souza

    2009-03-01

    Full Text Available The availability of a complex system, such as a gas turbine, is strongly associated with its parts reliability and maintenance policy. That policy not only has influence on the parts’ repair time but also on the parts’ reliability affecting the system degradation and availability. This study presents a method for reliability and availability evaluation of gas turbines installed in an electric power station. The method is based on system reliability concepts, such as functional tree development, application of failure mode and effects analysis to identify critical components for improvement of system reliability, and reliability and maintainability evaluation based on a historical failure database. The method also proposes the application of Reliability Centered Maintenance concepts to improve complex system maintenance policies aimed at the reduction of unexpected failure occurrences in critical components. The method is applied to the analysis of two F series gas turbines, each with an output of 150 MW, installed in a 500 MW combined cycle power plant. The reliability and availability of the turbines are simulated based on a five-year failure database. The availability analysis shows different results for each turbine, one presenting 99% and the other 96% availability, indicating differences in their systems installation and operation.

  12. Micro analysis of disolved gases by the gas chromatography technique

    International Nuclear Information System (INIS)

    A technique which allows the quantitative analysis of small concentration of disolved gases such as CO2 and H2 in the order of 10-6 - 10-3M is discussed. For the extraction, separation and quantification a Toepler pump was used. This is in tandem to a gas chromatography. This method also can be applied for the analysis of other gases like CO, CH4, CH3-CH3 etc. This technique may be applied in fields such as radiation chemistry, oceanography and environmental studies. (author)

  13. Model for analysis of counter-current gas transfer in fish gills.

    Science.gov (United States)

    Scheid, P; Hook, C; Piiper, J

    1986-06-01

    The validity of previously used simplified models for the analysis of gas transfer in fish gills was tested using an integrated model which includes water flow and blood flow in counter-current arrangement. The model accounts for the resistance to diffusion of O2 both in the water-blood barrier and in the interlamellar water, which is assumed to flow with a parabolic velocity profile between the secondary lamellae. The O2 diffusing capacity (transfer factor) for this model (Dint) was compared to that (Dm + w) calculated from the diffusing capacity of the water-blood barrier (Dm), and from the effective diffusive conductance of the parabolically streaming interlamellar water (Dw) as 1/Dm + w = 1/Dm + 1/Dw. These diffusing capacities were compared with that (Dadd) calculated from Dm and diffusing capacity of a water layer of 1/4 thickness of the interlamellar space (Dw) as 1/Dadd = 1/Dm + 1/Dw. Calculations with morphometric and gas exchange parameters in the elasmobranch Scyliorhinus stellaris reveal the following features: (1) In physiological conditions, Dm + w and Dint are similar to within 10%, but Dint is always higher. (2) Dint and Dm + w increase with increasing ventilation; Dint increases with decreasing perfusion, while Dm + w remains constant. (3) Both Dint and Dm + w agree reasonably well with Dadd. In other anatomical and physiological conditions, particularly for relatively high Dm, Dw, and Dw and high ventilation, greater discrepancies between Dint and Dm + w may occur but Dm + w appears to represent a reasonable approximation of the effective O2 diffusing capacity, which is best modelled as Dint. PMID:3738259

  14. A varying polytropic gas universe and phase space analysis

    Science.gov (United States)

    Khurshudyan, M.

    2016-05-01

    In this paper, we will consider a phenomenological model of a dark fluid that is able to explain an accelerated expansion of our low redshift universe and the phase transition to this accelerated expanding universe. Recent developments in modern cosmology towards understanding of the accelerated expansion of the large scale universe involve various scenarios and approaches. Among these approaches, one of well-known and accepted practice is modeling of the content of our universe via dark fluid. There are various models of dark energy fluid actively studied in recent literature and polytropic gas is among them. In this work, we will consider a varying polytropic gas which is a phenomenological modification of polytropic gas. Our model of varying polytropic dark fluid has been constructed to analogue to a varying Chaplygin gas actively discussed in the literature. We will consider interacting models, where dark matter is a pressureless fluid, to have a comprehensive picture. Phase space analysis is an elegant mathematical tool to earn general understanding of large scale universe and easily see an existence of a solution to cosmological coincidence problem. Imposing some constraints on parameters of the models, we found late time attractors for each case analytically. Cosmological consequences for the obtained late time attractors are discussed.

  15. Healthcare Chip for Checking Health Condition from Analysis of Trace Blood Collected by Painless Needle

    Science.gov (United States)

    Oki, Akio; Takai, Madoka; Ogawa, Hiroki; Takamura, Yuzuru; Fukasawa, Takayuki; Kikuchi, Jun; Ito, Yoshitaka; Ichiki, Takanori; Horiike, Yasuhiro

    2003-06-01

    A healthcare chip for checking the health condition at home has been studied based on the analysis of a trace amount of blood collected by a painless needle. A microcapillary as the main component for the blood flow was fabricated by molding its reverse pattern made of a quartz plate on a cheap and disposable poly(ethylene terephthalate) (PET) plate with an area of 2 cm× 2 cm. The painless needle was fabricated by polishing the tip of a stainless steel tube (SUS) with a 100 μm diameter at an angle of 10 degrees using chemical mechanical polishing (CMP) and subsequently finishing it by electropolishing. Coating the 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer on the inner surface of the capillary effectively suppressed the adsorption of corpuscles. A quartz electroosmosis flow pump embedded in the PET plate introduced the blood into a U-shaped capillary through the needle and the blood was centrifugally separated into the corpuscles and plasma on the chip. The plasma was then conveyed to ion-sensitive field-effect transistors (ISFETs) set on the capillary and the Na+ and K+ ion concentrations were measured with high selectivity. Finally, a series of chip operations from blood collection to measurements of the pH, Na+ and K+ ion concentrations was demonstrated.

  16. Evaluation of factor analysis and other functional images in exercise gated blood-pool study

    International Nuclear Information System (INIS)

    Factor analysis, a new method of functional imaging, has been applied to cardiovascular nuclear medicine. Because of the difficulty of its interpretation, it has not been popular as a method for detecting abnormal wall motion. The purpose of this study was to evaluate the usefulness of factor analysis in exercise gated blood-pool study in patients with ischemic heart disease. In our factor analysis, left ventricular region of interest (LVROI) was extracted to exclude the surrounding radioactivities. The new method was compared with the conventional factor analysis using whole region (whole ROI method), and the other functional images, i.e. stroke volume, ejection fraction and phase images. At first we tried 3-factor analysis of the LVROI method, which resulted in many uninterpretable factors. Whereas in 2-factor analysis no uninterpretable factors were extracted. In comparison with cine-mode display, the LVROI method with 2-factor analysis showed the best sensitivity (85%) and specificity (100%). In exercise gated blood-pool study, it became easier to detect abnormal wall motion by comparing the factor image at exercise with resting image. In conclusion, the 2-factor analysis using the LVROI method greatly improved the limitation of conventional factor analysis, and will be useful in detecting wall motion abnormality in patients with ischemic heart disase. (author)

  17. Analysis of Maisotsenko open gas turbine bottoming cycle

    International Nuclear Information System (INIS)

    Maisotsenko gas turbine cycle (MGTC) is a recently proposed humid air turbine cycle. An air saturator is employed for air heating and humidification purposes in MGTC. In this paper, MGTC is integrated as the bottoming cycle to a topping simple gas turbine as Maisotsenko bottoming cycle (MBC). A thermodynamic optimization is performed to illustrate the advantages and disadvantages of MBC as compared with air bottoming cycle (ABC). Furthermore, detailed sensitivity analysis is reported to present the effect of different operating parameters on the proposed configurations' performance. Efficiency enhancement of 3.7% is reported which results in more than 2600 tonne of natural gas fuel savings per year. - Highlights: • Developed an accurate air saturator model. • Introduced Maisotsenko bottoming cycle (MBC) as a power generation cycle. • Performed Thermodynamic optimization for MBC and air bottoming cycle (ABC). • Performed detailed sensitivity analysis for MBC under different operating conditions. • MBC has higher efficiency and specific net work output as compared to ABC

  18. Noble Gas Measurement and Analysis Technique for Monitoring Reprocessing Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Charlton, William S

    1999-09-01

    An environmental monitoring technique using analysis of stable noble gas isotopic ratios on-stack at a reprocessing facility was developed. This technique integrates existing technologies to strengthen safeguards at reprocessing facilities. The isotopic ratios are measured using a mass spectrometry system and are compared to a database of calculated isotopic ratios using a Bayesian data analysis method to determine specific fuel parameters (e.g., burnup, fuel type, fuel age, etc.). These inferred parameters can be used by investigators to verify operator declarations. A user-friendly software application (named NOVA) was developed for the application of this technique. NOVA included a Visual Basic user interface coupling a Bayesian data analysis procedure to a reactor physics database (calculated using the Monteburns 3.01 code system). The integrated system (mass spectrometry, reactor modeling, and data analysis) was validated using on-stack measurements during the reprocessing of target fuel from a U.S. production reactor and gas samples from the processing of EBR-II fast breeder reactor driver fuel. These measurements led to an inferred burnup that matched the declared burnup with sufficient accuracy and consistency for most safeguards applications. The NOVA code was also tested using numerous light water reactor measurements from the literature. NOVA was capable of accurately determining spent fuel type, burnup, and fuel age for these experimental results. Work should continue to demonstrate the robustness of this system for production, power, and research reactor fuels.

  19. Noble Gas Measurement and Analysis Technique for Monitoring Reprocessing Facilities

    International Nuclear Information System (INIS)

    An environmental monitoring technique using analysis of stable noble gas isotopic ratios on-stack at a reprocessing facility was developed. This technique integrates existing technologies to strengthen safeguards at reprocessing facilities. The isotopic ratios are measured using a mass spectrometry system and are compared to a database of calculated isotopic ratios using a Bayesian data analysis method to determine specific fuel parameters (e.g., burnup, fuel type, fuel age, etc.). These inferred parameters can be used by investigators to verify operator declarations. A user-friendly software application (named NOVA) was developed for the application of this technique. NOVA included a Visual Basic user interface coupling a Bayesian data analysis procedure to a reactor physics database (calculated using the Monteburns 3.01 code system). The integrated system (mass spectrometry, reactor modeling, and data analysis) was validated using on-stack measurements during the reprocessing of target fuel from a U.S. production reactor and gas samples from the processing of EBR-II fast breeder reactor driver fuel. These measurements led to an inferred burnup that matched the declared burnup with sufficient accuracy and consistency for most safeguards applications. The NOVA code was also tested using numerous light water reactor measurements from the literature. NOVA was capable of accurately determining spent fuel type, burnup, and fuel age for these experimental results. Work should continue to demonstrate the robustness of this system for production, power, and research reactor fuels

  20. Technical and financial analysis of combined cycle gas turbine

    Directory of Open Access Journals (Sweden)

    Khan Arshad Muhammad

    2013-01-01

    Full Text Available This paper presents technical and financial models which were developed in this study to predict the overall performance of combined cycle gas turbine plant in line with the needs of independent power producers in the liberalized market of power sector. Three similar sizes of combined cycle gas turbine power projects up to 200 Megawatt of independent power producers in Pakistan were selected in-order to develop and drive the basic assumptions for the inputs of the models in view of prevailing Government of Pakistan’s two components of electricity purchasing tariff that is energy purchase price and capacity purchase price at higher voltage grid station terminal from independent power producers. The levelized electricity purchasing tariff over life of plant on gaseous fuel at 60 percent plant load factor was 6.47 cent per kilowatt hour with energy purchase price and capacity purchase prices of 3.54 and 2.93 cents per kilowatt hour respectively. The outcome of technical models of gas turbine, steam turbine and combined cycle gas turbine power were found in close agreement with the projects under consideration and provides opportunity of evaluation of technical and financial aspects of combined cycle power plant in a more simplified manner with relatively accurate results. At 105 Celsius exit temperature of heat recovery steam generator flue gases the net efficiency of combined cycle gas turbine was 48.8 percent whereas at 125 Celsius exit temperature of heat recovery steam generator flue gases it was 48.0 percent. Sensitivity analysis of selected influential components of electricity tariff was also carried out.

  1. Startup analysis for a high temperature gas loaded heat pipe

    Science.gov (United States)

    Sockol, P. M.

    1973-01-01

    A model for the rapid startup of a high-temperature gas-loaded heat pipe is presented. A two-dimensional diffusion analysis is used to determine the rate of energy transport by the vapor between the hot and cold zones of the pipe. The vapor transport rate is then incorporated in a simple thermal model of the startup of a radiation-cooled heat pipe. Numerical results for an argon-lithium system show that radial diffusion to the cold wall can produce large vapor flow rates during a rapid startup. The results also show that startup is not initiated until the vapor pressure p sub v in the hot zone reaches a precise value proportional to the initial gas pressure p sub i. Through proper choice of p sub i, startup can be delayed until p sub v is large enough to support a heat-transfer rate sufficient to overcome a thermal load on the heat pipe.

  2. Thermal hydrodynamical analysis of a countercurrent gas centrifuge

    International Nuclear Information System (INIS)

    The separative effect in a centrifuge is amplified when a countercurrent in the axial direction is added to the centrifugal field. The mechanisms used to create this countercurrent are obtained with the gas deceleration near to the waste scoop, mechanical effect, and temperature distribution on the rotor walls, thermal effect. This work treats the influence of the thermal countercurrent on the centrifuge separative performance. A complete centrifuge model is presented, therefore this study passes by the hydrodynamical and thermal phenomena analysis. For the accomplishment of this work the gas flow is simulated inside the rotor, initially with arbitrary thermal boundary conditions. Then a structural thermal model is developed to supply the realistic boundary conditions for the hydrodynamical model. This procedure, with the integrated models, allows to propose and to evaluate configuration changes for a centrifuge minimizing the laboratory phase tests

  3. Commercial sector gas cooling technology frontier and market share analysis

    International Nuclear Information System (INIS)

    This paper describes a method, developed for the Gas Research Institute of the United States, that can assist planning for commercial sector natural gas cooling systems R and D. These systems are higher in first cost than conventional electric chillers. Yet, engine-driven chiller designs exist which are currently competitive in U.S. markets typified by high electricity or demand charges. Section II describes a scenario analysis approach used to develop and test the method. Section III defines the technology frontier, a conceptual tool for identifying new designs with sales potential. Section IV describes a discrete choice method for predicting market shares of technologies with sales potential. Section V shows how the method predicts operating parameter, cost, and/or performance goals for technologies without current sales potential (or for enhancing a frontier technology's sales potential). Section VI concludes with an illustrative example for the Chicago office building retrofit market

  4. Automotive Gas Turbine Power System-Performance Analysis Code

    Science.gov (United States)

    Juhasz, Albert J.

    1997-01-01

    An open cycle gas turbine numerical modelling code suitable for thermodynamic performance analysis (i.e. thermal efficiency, specific fuel consumption, cycle state points, working fluid flowrates etc.) of automotive and aircraft powerplant applications has been generated at the NASA Lewis Research Center's Power Technology Division. The use this code can be made available to automotive gas turbine preliminary design efforts, either in its present version, or, assuming that resources can be obtained to incorporate empirical models for component weight and packaging volume, in later version that includes the weight-volume estimator feature. The paper contains a brief discussion of the capabilities of the presently operational version of the code, including a listing of input and output parameters and actual sample output listings.

  5. Exergy Analysis of Overspray Process in Gas Turbine Systems

    Directory of Open Access Journals (Sweden)

    Kyoung Hoon Kim

    2012-07-01

    Full Text Available Gas turbine power can be augmented by overspray process which consists of inlet fogging and wet compression. In this study exergy analysis of the overspray process in gas turbine system is carried out with a non-equilibrium analytical modeling based on droplet evaporation and the second law of thermodynamics. This work focuses on the effects of system parameters such as pressure ratio, water injection ratio, and initial droplet diameter on exergetical performances including irreversibility and exergy efficiency of the process. The process performances are also estimated under the condition of saturated water injection ratio above which complete evaporation of injected water droplets within a compressor is not possible. The results show that the irreversibility increases but the saturated irreversibility decreases with increasing initial droplet diameter for a specified pressure ratio.

  6. Effects of breathing a hyperoxic hypercapnic gas mixture on blood oxygenation and vascularity of head-and-neck tumors as measured by magnetic resonance imaging

    International Nuclear Information System (INIS)

    Purpose: For head-and-neck tumors, breathing a hyperoxic hypercapnic gas mixture and administration of nicotinamide has been shown to result in a significantly improved tumor response to accelerated radiotherapy (ARCON, Accelerated Radiotherapy with CarbOgen and Nicotinamide). This may be caused by improved tumor oxygenation, possibly mediated by vascular effects. In this study, both blood oxygenation and vascular effects of breathing a hyperoxic hypercapnic gas mixture (98% O2+2% CO2) were assessed by magnetic resonance imaging (MRI) in patients with head-and-neck tumors. Methods and Materials: Tumor vascularity and oxygenation were investigated by dynamic gadolinium contrast-enhanced MRI and blood oxygen level dependent (BOLD) MRI, respectively. Eleven patients with primary head-and-neck tumors were each measured twice; with and without breathing the hyperoxic hypercapnic gas mixture. Results: BOLD MR imaging revealed a significant increase of the MRI time constant of transverse magnetization decay (T2*) in the tumor during hypercapnic hyperoxygenation, which correlates to a decrease of the deoxyhemoglobin concentration. No changes in overall tumor vascularity were observed, as measured by the gadolinium contrast uptake rate in the tumor. Conclusion: Breathing a hyperoxic hypercapnic gas mixture improves tumor blood oxygenation in patients with head-and-neck tumors, which may contribute to the success of the ARCON therapy

  7. Environmental and occupational exposure to benzene by analysis of breath and blood.

    Science.gov (United States)

    Perbellini, L; Faccini, G B; Pasini, F; Cazzoli, F; Pistoia, S; Rosellini, R; Valsecchi, M; Brugnone, F

    1988-05-01

    Benzene exposure of chemical workers was studied, during the entire workshift, by continuous monitoring of workplace benzene concentration, and 16 hours after the end of the workshift by the measurement of alveolar and blood benzene concentrations and excretion of urinary phenol. Exposure of hospital staff was studied by measuring benzene concentrations in the alveolar and blood samples collected during the hospital workshift. Instantaneous environmental air samples were also collected, at the moment of the biological sampling, for all the subjects tested. A group of 34 chemical workers showed an eight hour exposure to benzene, as a geometric mean, of 1.12 micrograms/l which corresponded, 16 hours after the end of the workshift, to a geometric mean benzene concentration of 70 ng/l in the alveolar air and 597 ng/l in the blood. Another group of 27 chemical workers (group A) turned out to be exposed to an indeterminable eight hour exposure to benzene that corresponded, the morning after, to a geometric mean benzene concentration of 28 ng/l in the alveolar air and 256 ng/l in the blood. The group of hospital staff (group B) had a benzene concentration of 14 ng/l in the alveolar air and 269 ng/l in the blood. Instantaneous environmental samples showed that in the infirmaries the geometric mean benzene concentration was 58 ng/l during the examination of the 34 chemical workers, 36 ng/l during the examination of the 27 chemical workers (group A), and 5 ng/l during the examination of the 19 subjects of the hospital staff (group B). Statistical analysis showed that the alveolar and blood benzene concentrations in the 34 workers exposed to 1.12 microgram/l of benzene differed significantly from those in groups A and B. It was found, moreover, that the alveolar and blood benzene concentrations were higher in the smokers in groups A and B but not in the smokers in the group of 34 chemical workers. The slope of the linear correlation between the alveolar and the instantaneous

  8. Infrared spectroscopic approach for diagnosis of cancer via analysis of blood samples and chemometric data processing

    International Nuclear Information System (INIS)

    Complete text of publication follows. Recently, Fourier transform infrared (FTIR) microspectroscopy has been employed to detect cancer tissues from normal ones. In most of these researches the infrared spectral characteristics have been analyzed by statistical tools to study variations in metabolites. An important analytical advantage of FT-IR is that no sample content modification is required before analysis. FTIR data can be used as molecular signatures for physiological status once the spectral patterns are correlated with biological properties. Studying the tissue samples has drawbacks such as difficult sampling, low speed sample preparation and very sensitive keeping conditions. Also sample contamination would affect the diagnosis results while the sampling procedure from human may help the malignancy to be more developed. Thus, it seems necessary to look after a substitute for tissue samples which would be easier in providing and analysis, while its results are reliable. According to our literature survey, there was no report to indicate the analysis of whole blood by spectroscopy for cancer diagnosis. In this work, first, we used whole blood sample instead of tissue because sample preparation procedure is very simple in blood study. It was tried to classify the blood samples in normal and cancer cases by chemometric techniques i.e. LDA, PCA and Cluster analysis. Initial results showed that the normal and malignant blood samples could be identified with 85% of accuracy. In order to specify our studies, basal cell carcinoma (BCC) and breast cancer were selected. Of course the metastasis of BCC is seldom reported but observations in protein content of skin would be a useful mark in order to design a new diagnosis method based on blood analysis. Soft Independent Modeling Class Analogy (SIMCA) classification method was applied for pattern recognition of blood samples in order to obtain if they are normal or cancerous. Results showed about 90% of accuracy

  9. Study on effect of supplementing iron-fortified food to children athletes by nuclear analysis and blood analysis techniques

    International Nuclear Information System (INIS)

    The iron content in hair and blood for 37 children athletes who were supplemented with 0, 8 and 16 mg Fe/d, respectively, in the form of ferrous gluconate-containing chocolate for 3 months was determined before and after the supplement by INAA, SRXRF and blood analysis. The experimental results indicated that after the supplement of the iron-fortified food, the ferritin level in blood of the male athletes attained to normal and the iron content in hair was increased with the increasing level of supplement, but not in direct proportion. Most of the female athletes had similar results. It is suggested that supplement of 8 mg Fe/d to a child athlete may be adequate

  10. Study on the effect of supplementation of ironfortified food to chinese juvenile athletes by nuclear analysis techniques and blood analysis

    International Nuclear Information System (INIS)

    The iron contents in the hair and blood samples of 37 juvenile athletes who were supplemented with 0, 8 and 16 mg Fe/day, respectively, in the food of ferrous gluconatecontaining chocolate for 3 months were determined before and after the supplementation by INAA, SRXRF and blood analysis. The experimental results showed that after supplementation of the iron-fortified food, the normal ferritin level in the blood of the male athletes was attained and the iron content in the hair was increased with supplementation, but both are not in the positive proportion. Most of the female athletes had similar results. It is suggested that supplementation of 8 mg iron/day to juvenile athletes may be desirable. (author). 3 refs., 4 figs., 1 tab

  11. Analysis of the Retained Gas Sample (RGS) Extruder Assembly

    International Nuclear Information System (INIS)

    In order for the Retained Gas Sample (RGS) Extruder Assembly to be safely used it was determined by the cognizant engineer that analysis was necessary. The use of the finite-element analysis (FEA) progarm COSMOS/M version 1.71 permitted a quick, easy, and detailed stress analysis of the RGS Extruder Assembly. The FEA model is a three dimensional model using the SHELL4T element type. From the results of the FEA, the cognizant engineer determined that the RGS extruder would be rated at 10,000 lbf and load tested to 12,000 lbf. The respective input and output files for the model are EXTR02.GFM and EXTR02.OUT and can be found on the attached tape

  12. a comparative analysis of fission gas diffusion models in pressurized water reactor fuels

    International Nuclear Information System (INIS)

    Calculation of fission gas release has a great importance in thermal and mechanical analysis of nuclear fuel. In general, gas release calculations have been carried out with mechanical or probabilistic gas release models which have details in microstructure relations at different level.In this study, a standard PWR fuel at different power levels and burnups was modeled with FRAPCON-2 computer program. Four fission gas release models: Beyer-Hann, ANS5-4, MacDonald-Weisman, and Grass were used in fission gas release calculation. Results were evaluated on the basis of fuel parameters such as fuel temperature, fuel rod gas increase, fuel rod gas pressure and gas release fraction

  13. Spectral Analysis of Blood Pressure Variability as a Quantitative Indicator of Driving Fatigue

    Institute of Scientific and Technical Information of China (English)

    李增勇; 焦昆; 陈铭; 王成焘

    2004-01-01

    The quantitative detector of driver fatigue presents appropriate warnings and helps to prevent traffic accidents.The aim of this study was to quantifiably evaluate driver mental fatigue using the power spectral analysis of the blood pressure variability (BPV) and subjective evaluation. In this experiment twenty healthy male subjects were required to perform a driving simulator task for 3-hours. The physiological variables for evaluating driver mental fatigue were spectral values of blood pressure variability (BPV)including very low frequency (VLF), low frequency (LF),high frequency (HF). As a result, LF, HF and LF/HF showed high correlations with driver mental fatigue but not found in VLF. The findings represent a possible utility of BPV spectral analysis in quantitatively evaluating driver mental fatigue.

  14. Multiscale analysis of heart rate, blood pressure and respiration time series

    CERN Document Server

    Angelini, L; Marinazzo, D; Nitti, L; Pellicoro, M; Pinna, G D; Stramaglia, S; Tupputi, S A

    2005-01-01

    We present the multiscale entropy analysis of short term physiological time series of simultaneously acquired samples of heart rate, blood pressure and lung volume, from healthy subjects and from subjects with Chronic Heart Failure. Evaluating the complexity of signals at the multiple time scales inherent in physiologic dynamics, we find that healthy subjects show more complex time series at large time scales; on the other hand, at fast time scales, which are more influenced by respiration, the pathologic dynamics of blood pressure is the most random. These results robustly separate healthy and pathologic groups. We also propose a multiscale approach to evaluate interactions between time series, by performing a multivariate autoregressive modelling of the coarse grained time series: this analysis provides several new quantitative indicators which are statistically correlated with the pathology.

  15. Results of the analysis of the blood lymphocyte proliferation test data from the National Jewish Center

    Energy Technology Data Exchange (ETDEWEB)

    From, E.L. [Oak Ridge National Lab., TN (United States). Mathematical Sciences Section; Newman, L.S.; Mroz, M.M. [National Jewish Center for Immunology and Respiratory Medicine, Denver, CO (United States)

    1997-03-01

    A new approach to the analysis of the blood beryllium lymphocyte proliferation test (LPT) was presented to the Committee to Accredit Beryllium Sensitization Testing-Beryllium Industry Scientific Advisory Committee in April, 1994. Two new outlier resistant methods were proposed for the analysis of the blood LPT and compared with the approach then in use by most labs. The National Jewish Center (NJC) agreed to provide data from a study that was underway at that time. Three groups of LPT data are considered: (1) a sample of 168 beryllium exposed (BE) workers and 20 nonexposed (NE) persons; (2) 25 unacceptable LPTs, and (3) 32 abnormal LPTs for individuals known to have chronic beryllium disease (CBD). The LAV method described in ORNL-6818 was applied to each LPT. Graphical and numerical summaries similar to those presented for the ORISE data are given. Three methods were used to identify abnormal LPTs. All three methods correctly identified the 32 known CBD cases as abnormal.

  16. Analysis of discard of whole blood and its components with suggested possible strategies to reduce it

    OpenAIRE

    Parikshit Patil; Arvind Bhake; Kishor Hiwale

    2016-01-01

    Background: Advances in medical technology demand more and more provision of safe blood for effective management of patients. To tackle with the demand and supply of blood and blood components, more stringent criteria should be applied for blood donations and for proper utilization of blood. The present study was designed to analyze the various reasons for the discard of whole blood and blood components. It also intended to suggest various possible strategies for optimum utilization of blood ...

  17. Offsite radiological consequence analysis for the bounding flammable gas accident

    International Nuclear Information System (INIS)

    The purpose of this analysis is to calculate the offsite radiological consequence of the bounding flammable gas accident. DOE-STD-3009-94, ''Preparation Guide for U.S. Department of Energy Nonreactor Nuclear Facility Documented Safety Analyses'', requires the formal quantification of a limited subset of accidents representing a complete set of bounding conditions. The results of these analyses are then evaluated to determine if they challenge the DOE-STD-3009-94, Appendix A, ''Evaluation Guideline,'' of 25 rem total effective dose equivalent in order to identify and evaluate safety class structures, systems, and components. The bounding flammable gas accident is a detonation in a single-shell tank (SST). A detonation versus a deflagration was selected for analysis because the faster flame speed of a detonation can potentially result in a larger release of respirable material. As will be shown, the consequences of a detonation in either an SST or a double-shell tank (DST) are approximately equal. A detonation in an SST was selected as the bounding condition because the estimated respirable release masses are the same and because the doses per unit quantity of waste inhaled are generally greater for SSTs than for DSTs. Appendix A contains a DST analysis for comparison purposes

  18. Comparison and agreement between venous and arterial gas analysis in cardiopulmonary patients in Kashmir valley of the Indian subcontinent

    Directory of Open Access Journals (Sweden)

    Koul Parvaiz

    2011-01-01

    Full Text Available Background: Arterial blood gas (ABG analysis is routinely performed for sick patients but is fraught with complications, is painful, and is technically demanding. Objective: To ascertain agreement between the arterial and peripheral venous measurement of pH, pCO 2 , pO 2 , and bicarbonate levels in sick patients with cardiopulmonary disorders in the valley of Kashmir in the Indian subcontinent, so as to use venous gas analysis instead of arterial for assessment of patients. Setting: Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, a 650-bedded tertiary care hospital in North India located at an altitude of 1584 m. Methods: One hundred patients who required ABG analysis were admitted. Peripheral venous blood was drawn within 5 min of an ABG measurement, and the samples analyzed immediately on a point of care automated ABG analyzer. Finger pulse oximetry was used to obtain oxygen (SpO 2 saturation. Data were analyzed using Pearson correlation and bias (Bland Altman methods. Results: The venous measurements of pH, pCO 2 , pO 2 and bicarbonate, and the digital oxygen saturation were highly correlated with their corresponding arterial measurements. Bland Altman plots demonstrated a high degree of agreement between the two corresponding sets of measurements with clinically acceptable differences. The difference in pO 2 measurements was, however, higher (-22.34 ± 15.23 although the arterial saturation and finger oximetry revealed a good degree of agreement with clinically acceptable bias. Conclusion: Peripheral venous blood gas assessment in conjunction with finger pulse oximetry can obviate the routine use of arterial puncture in patients requiring ABG analysis.

  19. Recent trends on the stent research for blood arteries by bibliometric analysis

    OpenAIRE

    Ahn, Sejung; Sung, Jung-Suk; Choi, Brad; Kim, Hackjoo; Sung, Yong Kiel

    2014-01-01

    The research trends on stent for blood arteries are reviewed by bibliometric analysis using 7,790 journal articles published from 1986 to 2013 of the Web of Science database. The bibliometric indicators are applied to analyze the journal article data, which are simple number of publications for selecting key players, citation indicators for measuring qualitative research performance, collaboration indicators for figuring out the degree of international collaboration and keyword mapping for id...

  20. Uptitrating amlodipine significantly reduces blood pressure in diabetic patients with hypertension: a retrospective, pooled analysis

    OpenAIRE

    Jeffers BW; Bhambri R; Robbins J

    2014-01-01

    Barrett W Jeffers, Rahul Bhambri, Jeffery Robbins Pfizer Inc., New York, NY, USA Abstract: Diabetic patients with hypertension are approximately twice as likely to develop cardiovascular disease as non-diabetic patients with hypertension. Given that hypertension affects ~60% of patients with diabetes, effective blood pressure (BP) management is important in this high-risk population. This post-hoc analysis pooled data from six clinical studies to quantify additional BP efficacy achieved when...

  1. Ambulatory Blood Pressure Monitoring in Individuals with HIV: A Systematic Review and Meta-Analysis

    OpenAIRE

    Kent, Shia T; Bromfield, Samantha G.; Burkholder, Greer A.; Falzon, Louise; Oparil, Suzanne; Overton, Edgar T.; Mugavero, Michael J.; Schwartz, Joseph E.; Shimbo, Daichi; Muntner, Paul

    2016-01-01

    Introduction Abnormal diurnal blood pressure (BP) rhythms may contribute to the high cardiovascular disease risk in HIV-positive (HIV+) individuals. To synthesize the current literature on ambulatory BP monitoring (ABPM) in HIV+ individuals, a systematic literature review and meta-analysis were performed. Methods Medical databases were searched through November 11, 2015 for studies that reported ABPM results in HIV+ individuals. Data were extracted by 2 reviewers and pooled differences betwee...

  2. TCRgamma gene rearrangement analysis in skin samples and peripheral blood of mycosis fungoides patients:

    OpenAIRE

    Bašanović, Jelena; Cikota, Bojana; Kandolf Sekulović, Lidija; Magić, Zvonko; Medenica, Ljiljana; Pavlović, Miloš; Stojadinović, Olivera; Škiljević, Dušan

    2007-01-01

    Background: Diagnosing mycosis fungoides (MF) can be challenging in the early stage of the disease because histopathological features may simulate a varietyof benign inflammatory skin diseases. Assessment of T-cell clonality was found to be useful in diagnosis and follow-up of patients. Objective: In this study, PCR-based TCRgamma gene rearrangement analysis was performed in skin and peripheral blood samples of patients with MF treated at the two largest referral centers in Serbia, and the re...

  3. Gas Analysis by Fourier Transform Mm-Wave Spectroscopy

    Science.gov (United States)

    Harris, Brent J.; Steber, Amanda L.; Lehmann, Kevin K.; Pate, Brooks H.

    2013-06-01

    Molecular rotational spectroscopy of low pressure, room temperature gases offers high chemical selectivity and sensitivity with the potential for a wide range of applications in gas analysis. A strength of the technique is the potential to identify molecules that have not been previously studied by rotational spectroscopy by comparing experimental results to predictions of the spectroscopic parameters from quantum chemistry -6 so called library-free detection. The development of Fourier transform mm-wave spectrometers using high peak power (30 mW) active multiplier chain mm-wave sources brings new measurement capabilities to the analysis of complex gas mixtures. Strategies for gas analysis based on high-throughput mm-wave spectroscopy and arbitrary waveform generator driven mm-wave sources are described. Several new measurement capabilities come from the intrinsic time-domain measurement technique. High-sensitivity double-resonance measurements can be performed to speed the analysis of a complex gas sample containing several species. This technique uses a "pi-pulse" to selectively invert the population of two selected rotational energy levels and the effect of this excitation pulse on all other transitions in the spectrometer operating range is monitored using segmented chirped-pulse Fourier transform spectroscopy. This method can lead to automated determination of the molecular rotational constants. Rapid pulse duration scan experiments can be used to estimate the magnitude and direction of the dipole moment of the molecule from an unknown spectrum. Coherent pulse echo experiments, using the traditional Hahn sequence or two-color population recovery methods, can be used to determine the collisional relaxation rate of the unknown molecule. This rate determination improves the ability to estimate the mass of the unknown molecule from the determination of the Doppler dephasing rate. By performing a suite of automated, high-throughput measurements, there is the

  4. Effect of different dosages of nitroglycerin infusion on arterial blood gas tensions in patients undergoing on- pump coronary artery bypass graft surgery

    OpenAIRE

    Gholamreza Masoumi; Evaz Hidar Pour; Ali Sadeghpour; Mohsen Ziayeefard; Mostapha Alavi; Sanam Javid Anbardan; Shahin shirani

    2012-01-01

    Background: On-pump coronary artery bypass graft (CABG) surgery impairs gas exchange in the early postoperative period. The main object on this study was evaluation of changes in arterial blood gas values in patients underwent on pump CABG surgery receiving different dose of intravenous nitroglycerin (NTG). Materials and Methods: sixty-seven consecutive patients undergoing elective on-pump CABG randomly enrolled into three groups receiving NTG 50 μg/min (Group N1, n =67), 100 μg/min (Group N2...

  5. Involvement of placental/umbilical cord blood acid–base status and gas values on the radiosensitivity of human fetal/neonatal hematopoietic stem/progenitor cells

    OpenAIRE

    Yamaguchi, Masaru; EBINA, SATOKO; Kashiwakura, Ikuo

    2012-01-01

    Arterial cord blood (CB) acid–base status and gas values, such as pH, PCO2, PO2, HCO3 −and base excess, provide useful information on the fetal and neonatal condition. However, it remains unknown whether these values affect the radiosensitivity of fetal/neonatal hematopoiesis. The present study evaluated the relationship between arterial CB acid–base status, gas values, and the radiosensitivity of CB hematopoietic stem/progenitor cells (HSPCs). A total of 25 CB units were collected. The arter...

  6. Effects of Vegetarian Diets on Blood Lipids: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

    OpenAIRE

    Wang, Fenglei; Zheng, Jusheng; Yang, Bo; Jiang, Jiajing; Fu, Yuanqing; Li, Duo

    2015-01-01

    Background Vegetarian diets exclude all animal flesh and are being widely adopted by an increasing number of people; however, effects on blood lipid concentrations remain unclear. This meta‐analysis aimed to quantitatively assess the overall effects of vegetarian diets on blood lipids. Methods and Results We searched PubMed, Scopus, Embase, ISI Web of Knowledge, and the Cochrane Library through March 2015. Studies were included if they described the effectiveness of vegetarian diets on blood ...

  7. 3-Methylmethcathinone-Interpretation of Blood Concentrations Based on Analysis of 95 Cases.

    Science.gov (United States)

    Adamowicz, Piotr; Gieroń, Joanna; Gil, Dominika; Lechowicz, Wojciech; Skulska, Agnieszka; Tokarczyk, Bogdan

    2016-05-01

    3-Methylmethcathinone (3-MMC) has been one of the most popular new psychoactive substances (NPS) in Poland in recent years. 3-MMC was found in blood in 95 cases sent to the Institute of Forensic Research (IFR) during the two and a half year period, from 2013 to half of 2015. 3-MMC was determined in 13 and 48 cases in 2013 and 2014 year-round casework, respectively, while only in the first half of 2015 year it was present in 34 cases. In most cases, 3-MMC was detected together with other novel psychoactive substances and conventional drugs. Blood analyses for 3-MMC were carried out using liquid chromatography-tandem mass spectrometry (LC-MS-MS). The concentrations of 3-MMC in all 95 cases were in the range from traces (accidents: <1-29 ng/mL; drug possession: 2-408 ng/mL; intoxication: <1-1600 ng/mL and other: <1-61 ng/mL. The parameters of the developed method such as the LOD (0.02 ng/mL) and LOQ (1 ng/mL) demonstrate that the method is well suited for the analysis of blood samples for 3-MMC and covers the range of typical blood concentrations. PMID:26989222

  8. The effect of adding CO2 to hypoxic inspired gas on cerebral blood flow velocity and breathing during incremental exercise.

    Directory of Open Access Journals (Sweden)

    Jui-Lin Fan

    Full Text Available Hypoxia increases the ventilatory response to exercise, which leads to hyperventilation-induced hypocapnia and subsequent reduction in cerebral blood flow (CBF. We studied the effects of adding CO2 to a hypoxic inspired gas on CBF during heavy exercise in an altitude naïve population. We hypothesized that augmented inspired CO2 and hypoxia would exert synergistic effects on increasing CBF during exercise, which would improve exercise capacity compared to hypocapnic hypoxia. We also examined the responsiveness of CO2 and O2 chemoreception on the regulation ventilation ([Formula: see text]E during incremental exercise. We measured middle cerebral artery velocity (MCAv; index of CBF, [Formula: see text]E, end-tidal PCO2, respiratory compensation threshold (RC and ventilatory response to exercise ([Formula: see text]E slope in ten healthy men during incremental cycling to exhaustion in normoxia and hypoxia (FIO2 = 0.10 with and without augmenting the fraction of inspired CO2 (FICO2. During exercise in normoxia, augmenting FICO2 elevated MCAv throughout exercise and lowered both RC onset and[Formula: see text]E slope below RC (P0.05. The [Formula: see text]E slope above RC was unchanged with either hypoxia or augmented FICO2 (P>0.05. We found augmenting FICO2 increased CBF during sub-maximal exercise in normoxia, but not in hypoxia, indicating that the 'normal' cerebrovascular response to hypercapnia is blunted during exercise in hypoxia, possibly due to an exhaustion of cerebral vasodilatory reserve. This finding may explain the lack of improvement of exercise capacity in hypoxia with augmented CO2. Our data further indicate that, during exercise below RC, chemoreception is responsive, while above RC the ventilatory response to CO2 is blunted.

  9. Different fasting periods in tiletamine-zolezepam-anethetized cats: Glycemia, recovery, blood-gas and cardiorrespiratory parameters

    Directory of Open Access Journals (Sweden)

    A.P. Gering

    2013-12-01

    Full Text Available The effects of different fasting periods on glycemia levels and on cardiorrespiratory parameters in tiletamine-zolazepam-anesthetized cats were evaluated. Twenty one animals were randomly assigned to three groups: 8 hours (G8, 12 hours (G12 or 18 hours (G18 of the preoperative fasting. The tiletamine-zolazepam (2 mg/kg was administered intravenously. The heart rate (HR, respiratory rate (fR, rectal temperature (T R, glycemia (G, laboratorial glycemia (Glab, venous oxygen partial pressure (PvO2, venous carbon dioxide partial pressure (PvCO2, venous hemoglobin saturation (SvO2, pH, base deficit (BD, bicarbonate concentration (HCO3- and haematocrit were evaluated at 90 minutes after the last meal (T0, immediately before anesthesia (T1 and at ten (T2 and thirty (T3 minutes after tiletamine-zolezepam administration. The time between the administration of anesthetic and the cat's trial to elevate head (Th and the interval between drug administration and aniamal's quadrupedal position (Tqp were recorded. No differences among groups were recorded for glycemia, HR, PvO2, SvO2, pH, BD, HCO3-, Ht and Tqp. In G12 from T2, glycemia increased and from T1 PvCO2 decreased. At T1, PvO2 increased in all groups. In G8 and G12, from T1, DB and HCO3- decreased. In G12 and G18, from T2, Ht decreased. In G12, the Th mean was higher than G8. In conclusion, in tiletamine-zolazepam-anesthetized cats, the different preoperative fasting did not influence glycemia, blood-gas and cardiorrespiratory parameters. Additionally, there was no relationship between glycemia and anesthesia recovery.

  10. Measurement of methyl tert-butyl ether and tert-butyl alcohol in human blood by purge-and-trap gas chromatography-mass spectrometry using an isotope-dilution method.

    Science.gov (United States)

    Bonin, M A; Ashley, D L; Cardinali, F L; McCraw, J M; Wooten, J V

    1995-01-01

    We developed an isotope-dilution method for measuring methyl tert-butyl ether (MTBE) and tert-butyl alcohol (TBA) in whole human blood using a purge-and-trap gas chromatographic-mass spectrometric method. The labeled analogues for MTBE and TBA were [2H12]methyl tert-butyl ether and [2H9]-tert-butyl alcohol, respectively. Volatiles were removed from the blood by direct helium purging of the liquid; were trapped on a Tenax trap; and were desorbed, cryofocused, and chromatographed on a DB-624 capillary column that was connected directly to the ion source of a mass spectrometer. Detection was by mass analysis using a double-focusing magnetic-sector mass spectrometer operating in the full-scan mode at the medium mass resolution of 3000. For the isotope-dilution method, the minimum detection limits in blood (5-10 mL) are 0.01 microgram/L for MTBE and 0.06 microgram/L for TBA. The isotope-dilution method proved to be a big improvement in recovery, reproducibility, and sensitivity over our previous analytical method, which used the labeled ketone, [4-2H3]-2-butanone, as the internal standard for both MTBE and TBA. The isotope-dilution method has sufficient sensitivity for monitoring blood levels of MTBE and TBA in populations exposed to oxygenated fuels containing MTBE. PMID:7564298

  11. Sensitive KIT D816V mutation analysis of blood as a diagnostic test in mastocytosis

    DEFF Research Database (Denmark)

    Kielsgaard Kristensen, Thomas; Vestergaard, Hanne; Bindslev-Jensen, Carsten; Møller, Michael Boe; Broesby-Olsen, Sigurd

    2014-01-01

    The recent progress in sensitive KIT D816V mutation analysis suggests that mutation analysis of peripheral blood (PB) represents a promising diagnostic test in mastocytosis. However, there is a need for systematic assessment of the analytical sensitivity and specificity of the approach in order to...... establish its value in clinical use. We therefore evaluated sensitive KIT D816V mutation analysis of PB as a diagnostic test in an entire case-series of adults with mastocytosis. We demonstrate for the first time that by using a sufficiently sensitive KIT D816V mutation analysis, it is possible to detect...... the mutation in PB in nearly all adult mastocytosis patients. The mutation was detected in PB in 78 of 83 systemic mastocytosis (94%) and 3 of 4 cutaneous mastocytosis patients (75%). The test was 100% specific as determined by analysis of clinically relevant control patients who all tested negative...

  12. Analysis of plasma jets generated in gas and gas-water torches

    Czech Academy of Sciences Publication Activity Database

    Kavka, Tetyana; Hrabovský, Milan; Chumak, Oleksiy

    Saint-Petersburg, 2006. s. 1-1. [High Technology Plasma Processes 9. 27.5.2006-4.6.2006, Saint-Petersburg] Institutional research plan: CEZ:AV0Z20430508 Keywords : Plasma jet * gas torch * hybrid gas-water torch * entrainment of ambient gas Subject RIV: BL - Plasma and Gas Discharge Physics

  13. Analysis of human blood and hair for trace elements by means of tertiary X-ray spectra

    International Nuclear Information System (INIS)

    A methodology for analysis of biological materials (blood, hair) for trace elements by x-ray fluorescence energy dispersive analysis using tertiary x-ray spectra has been proposed. Sample preparation and analytical instrumentation are described and analysis results are given. The method permits simultaneous determination of 13 elements in the blood and 15 elements in the hair with detection limit nx10-6%. 11 refs.; 1 fig.; 2 tabs

  14. Fourier analysis of a gated blood-pool study during atrial flutter

    International Nuclear Information System (INIS)

    First-harmonic Fourier analysis of a gated blood-pool study is based on the assumption that the cardiac chambers contract once per cardiac cycle. In atrial arrhythmias this condition may not exist for the atria. We recently studied a patient with atrial flutter and 2:1 artioventricular conduction. There were predictable alterations in the first-harmonic Fourier phase and amplitude images. The observed changes from first-harmonic Fourier analysis were: (a) very low atrial amplitude values, and (b) absence of identifiable atrial regions on the phase image

  15. Trace element analysis of blood samples from mentally challenged children by PIXE

    International Nuclear Information System (INIS)

    The accelerator based ion beam analysis method of proton induced X-ray emission (PIXE) has been used for analysing up to 14 elements in the blood serum of patients, collected from rehabilitation centres for the mentally retarded and from Medical College Hospital, Coimbatore, Tamil Nadu, India. The experimental subjects of the different groups displayed significant variations in their levels of certain trace elements such as zinc, iron, copper, phosphorus, chlorine, and rubidium. The results are compared with those of healthy control subjects and are discussed in detail in this paper. Hence, PIXE as a method of trace element analysis can be used to determine trace element content in mentally challenged patients

  16. Practical approach on gas pipeline compression system availability analysis

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Sidney Pereira dos [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil); Kurz, Rainer; Lubomirsky, Matvey [Solar Turbines, San Diego, CA (United States)

    2009-12-19

    Gas pipeline projects traditionally have been designed based on load factor and steady state flow. This approach exposes project sponsors to project sustainability risks due to potential losses of revenues and transportation contract penalties related to pipeline capacity shortage as consequence of compressor unit's unavailability. Such unavailability should previously be quantified during the design phase. This paper presents a case study and a methodology that highlights the practical benefits of applying Monte Carlo simulation for the compression system availability analysis in conjunction with quantitative risk analysis and economic feasibility study. Project economics main variables and their impacts on the project NPV (Net Present Value) are evaluated with their respective statistics distribution to quantify risk and support decision makers to adopt mitigating measures to guarantee competitiveness while protecting project sponsors from otherwise unpredictable risks. This practical approach is compared to load factor approach and the results are presented and evaluated. (author)

  17. Fractal Analysis of Gas Diffusion Layer in PEM Fuel Cells

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The aim of this study is to show how fractal analysis can be effectively used to characterize thetexture of porous solids.The materials under study were carbon papers, the backing material of the gas diffusion layer (GDL) in Proton Exchange Membrane Fuel Cell (PEMFC).The fractal dimensions were calculated byanalyzing data from mercury porosimetry.The polytotrafluoroethylene (PTFE) treated carbon paper shows a significantly high fractal dimension value than pure sample, and the high fractal dimension signifies that the physical complexity of the pore surface is enhanced.The fractal dimension can be used as a valid parameter to monitor the textural evolution of the samples ns the treatment progresses, ns this behaves in a similar way to other textural pa rameters.The use of fractal analysis in conjunction with the results of classical characterization methods leads to abetter understanding of textural modifications in the processing of materials.

  18. The application of FAIMS gas analysis in medical diagnostics.

    Science.gov (United States)

    Covington, J A; van der Schee, M P; Edge, A S L; Boyle, B; Savage, R S; Arasaradnam, R P

    2015-10-21

    There is an ever increasing need to develop new tools to aid in the diagnosis and monitoring of human diseases. Such tools will ultimately reduce the cost of healthcare by identifying disease states more quickly and cheaply than current practices. One method showing promise is the analysis of gas-phase biomarkers from human breath, urine, sweat and stool that reflect bodily metabolism. Analysis of these volatiles by GC MS requires specialised infra-structure and staff, making it unsuitable for a clinical setting. Point of care sensor based technologies such as eNoses often suffer from stability and sensitivity issues. Field-Asymmetric Ion Mobility Spectrometry (FAIMS) has potential to fulfil this clinical need. In this paper we review the medical need, the technology, sampling methods and medical evidence thus far. We conclude with reflecting on future developmental steps necessary to bring the device into medical practice. PMID:26205889

  19. Gas-Phase Fragmentation Analysis of Nitro-Fatty Acids

    Science.gov (United States)

    Bonacci, Gustavo; Asciutto, Eliana K.; Woodcock, Steven R.; Salvatore, Sonia R.; Freeman, Bruce A.; Schopfer, Francisco J.

    2011-09-01

    Nitro-fatty acids are electrophilic signaling mediators formed in increased amounts during inflammation by nitric oxide and nitrite-dependent redox reactions. A more rigorous characterization of endogenously-generated species requires additional understanding of their gas-phase induced fragmentation. Thus, collision induced dissociation (CID) of nitroalkane and nitroalkene groups in fatty acids were studied in the negative ion mode to provide mass spectrometric tools for their structural characterization. Fragmentation of nitroalkanes occurred mainly through loss of the NO{2/-} anion or neutral loss of HNO2. The CID of nitroalkenes proceeds via a more complex cyclization, followed by fragmentation to nitrile and aldehyde products. Gas-phase fragmentation of nitroalkene functional groups with additional γ or δ unsaturation occurred through a multiple step cyclization reaction process, leading to 5 and 6 member ring heterocyclic products and carbon chain fragmentation. Cyclization products were not obtained during nitroalkane fragmentation, highlighting the role of double bond π electrons during NO{2/-} rearrangements, stabilization and heterocycle formation. The proposed structures, mechanisms and products of fragmentation are supported by analysis of 13C and 15N labeled parent molecules, 6 different nitroalkene positional isomers, 6 nitroalkane positional isomers, accurate mass determinations at high resolution and quantum mechanics calculations. Multiple key diagnostic ion fragments were obtained through this analysis, allowing for the precise placement of double bonds and sites of fatty acid nitration, thus supporting an ability to predict nitro positions in biological samples.

  20. Unusual spontaneous cold auto-hemagglutination phenomenon in blood units stored under blood bank condition: A retrospective analysis

    Directory of Open Access Journals (Sweden)

    Sanmukh R Joshi

    2015-01-01

    Full Text Available Background: Cold agglutinins (CA are benign naturally occurring low titer autoantibodies present in most individuals. Those with moderate strength are found in infections, malignancies or autoimmune conditions with diagnostic importance. Aim: Present report deals with CA that brought spontaneous hemagglutination in blood units stored at 2-6°C. Study design: Over 32 months period between July 1993 and December 1995, blood units were inspected for spontaneous cold auto-hemagglutination (SpCA phenomenon. The plasma from these units was separated and investigated for serological specificity using in house red cell panel and standard serological methods. Results: Among 51,671 blood units, 112 units showed SpCA phenomenon. A rising trend seen in first half of study period significantly fell in remaining half. Specificities of the antibodies detected include anti-I (27, anti-i (53, anti-Pr (21 with remaining few being undetermined specificity. Absorption of serum using enzyme-treated red cells revealed a presence of anti-Pr among the cases, the two of which with new specificities that reacted preferentially with red cells from either new-born or adults and were tentatively named as anti-Pr Fetal and anti-Pr adult , respectively. While 9 cases showed optimum reaction at neutral pH of 7, 68 (62% cases reacted at pH 5.8 through 8.0, 28 (26% cases preferred an acidic pH 5.8 and 4 cases opted an alkaline pH 8. Of 28 cases with antibodies preferentially reacting in acidic medium, 17 (60% cases were anti-i and 7 (25% cases were anti-Pr. Conclusion: Unique SpCA phenomenon observed in blood units stored under blood bank conditions seems to be due to CA developed in response to vector-borne infectious agents. Majority of the cases displayed their specificities, otherwise are rare to be encountered.

  1. The numerical analysis of non-Newtonian blood flow in human patient-specific left ventricle.

    Science.gov (United States)

    Doost, Siamak N; Zhong, Liang; Su, Boyang; Morsi, Yosry S

    2016-04-01

    Recently, various non-invasive tools such as the magnetic resonance image (MRI), ultrasound imaging (USI), computed tomography (CT), and the computational fluid dynamics (CFD) have been widely utilized to enhance our current understanding of the physiological parameters that affect the initiation and the progression of the cardiovascular diseases (CVDs) associated with heart failure (HF). In particular, the hemodynamics of left ventricle (LV) has attracted the attention of the researchers due to its significant role in the heart functionality. In this study, CFD owing its capability of predicting detailed flow field was adopted to model the blood flow in images-based patient-specific LV over cardiac cycle. In most published studies, the blood is modeled as Newtonian that is not entirely accurate as the blood viscosity varies with the shear rate in non-linear manner. In this paper, we studied the effect of Newtonian assumption on the degree of accuracy of intraventricular hemodynamics. In doing so, various non-Newtonian models and Newtonian model are used in the analysis of the intraventricular flow and the viscosity of the blood. Initially, we used the cardiac MRI images to reconstruct the time-resolved geometry of the patient-specific LV. After the unstructured mesh generation, the simulations were conducted in the CFD commercial solver FLUENT to analyze the intraventricular hemodynamic parameters. The findings indicate that the Newtonian assumption cannot adequately simulate the flow dynamic within the LV over the cardiac cycle, which can be attributed to the pulsatile and recirculation nature of the flow and the low blood shear rate. PMID:26849955

  2. Systematic review and meta-analysis of circulating S100B blood levels in schizophrenia.

    Directory of Open Access Journals (Sweden)

    Katina Aleksovska

    Full Text Available S100B is a calcium-binding protein secreted in central nervous system from astrocytes and other glia cells. High blood S100B levels have been linked to brain damage and psychiatric disorders. S100B levels have been reported to be higher in schizophrenics than healthy controls. To quantify the relationship between S100B blood levels and schizophrenia a systematic literature review of case-control studies published on this topic within July 3rd 2014 was carried out using three bibliographic databases: Medline, Scopus and Web of Science. Studies reporting mean and standard deviation of S100B blood levels both in cases and controls were included in the meta-analysis. The meta-Mean Ratio (mMR of S100B blood levels in cases compared to controls was used as a measure of effect along with its 95% Confidence Intervals (CI. 20 studies were included totaling for 994 cases and 785 controls. Schizophrenia patients showed 76% higher S100B blood levels than controls with mMR = 1.76 95% CI: 1.44-2.15. No difference could be found between drug-free patients with mMR = 1.84 95%CI: 1.24-2.74 and patients on antipsychotic medication with mMR = 1.75 95% CI: 1.41-2.16. Similarly, ethnicity and stage of disease didn't affect results. Although S100B could be regarded as a possible biomarker of schizophrenia, limitations should be accounted when interpreting results, especially because of the high heterogeneity that remained >70%, even after carrying out subgroups analyses. These results point out that approaches based on traditional categorical diagnoses may be too restrictive and new approaches based on the characterization of new complex phenotypes should be considered.

  3. Development of a preparation and staining method for fetal erythroblasts in maternal blood : Simultaneous immunocytochemical staining and FISH analysis

    NARCIS (Netherlands)

    Oosterwijk, JC; Mesker, WE; Ouwerkerk-van Velzen, MCM; Knepfle, CFHM; Wiesmeijer, KC; van den Burg, MJM; Beverstock, GC; Bernini, LF; van Ommen, Gert-Jan B; Kanhai, HHH; Tanke, HJ

    1998-01-01

    In order to detect fetal nucleated red blood cells (NRBCs) in maternal blood, a protocol was developed which aimed at producing a reliable staining method for combined immunocytochemical and FISH analysis. The technique had to be suitable for eventual automated screening of slides. Chorionic villi w

  4. [Research of Outlier Samples Elimination Methods for Near-Infrared Spectral Analysis of Blood Glucose].

    Science.gov (United States)

    Lin, Yongzhong; Li, Lina; Lin, Tianliang

    2015-12-01

    For the near-infrared (NIR) spectral analysis of the concentration of blood glucose, the calibration accuracy can be affected because of the existing of outlier samples. In this research, a Monte-Carlo cross validation (MCCV) method is constructed for eliminating outlier samples. The human blood plasma experiment in vitro and the human body experiment in vivo were introduced to evaluate the MCCV method for its application effect in NIR spectral analysis of blood glucose. And the uninformative sample elimination method based on modified uninformative variable elimination (MUVE-USE) was employed in this study for the comparison with MCCV. The results indicated that, like the MUVE-USE method, the outlier samples elimination method based on MCCV could be used to eliminate the outlier samples which came from gross errors (such as bad sample) or system errors (such as baseline drift). In addition, the outlier samples from the random errors of uncertain causes which affect model accuracy can be eliminated simultaneously by MCCV. The elimination of multiple outlier samples is beneficial to the improvement of prediction accuracy of calibration model. PMID:27079108

  5. Hemocytome: deep sequencing analysis of mosquito blood cells in Indian malarial vector Anopheles stephensi.

    Science.gov (United States)

    Thomas, Tina; De, Tanwee Das; Sharma, Punita; Lata, Suman; Saraswat, Priyanka; Pandey, Kailash C; Dixit, Rajnikant

    2016-07-10

    Hemocytes are tiny circulating blood cells of insects known to play multiple roles in physiological as well as cellular immune responses. However, the molecular nature of hemocytes in blood feeding insects, especially mosquitoes which transmit several deadly diseases such as malaria, dengue etc. is still limited. Therefore, to know the basic molecular composition of naïve mosquito hemocyte encoded proteins, we sequenced RNA-Seq library and analyzed a total of 13,105,858 Illumina sequencing reads in the mosquito Anopheles stephensi, an urban malarial vector in India. Denovo assembly approach yielded a buildup of 3025 contigs, for molecular and functional annotation. A total of 1829 contigs (48%) could be mapped to the mosquito transcript database, while out of remaining 1196 unmatched contigs, at least 1108 contigs i.e. 40% of total contigs, yielded a significant match to the available draft genome. ImmunoDB analysis predicted a total of 88 putative hemocyte transcripts belonging to 11 immune family proteins. A comprehensive molecular analysis of several unique transcripts including novel LRR, Holotricin, OBP, NiFU, that are involved in immunity, chemo sensing, cell-cell communication, nitrogen fixation/metabolism etc. provides initial evidence that mosquito hemocytes carry unique ability to meet and manage cell specific diverse functions of the mosquito blood. An unexpected observation of abundant transcripts encoding hypothetical proteins with unknown functions indicated that a much of the hemocyte biology remains to be understood. PMID:26915489

  6. Numerical analysis of bypass model geometrical parameters influence on pulsatile blood flow

    Directory of Open Access Journals (Sweden)

    Jonášová A.

    2011-06-01

    Full Text Available The present study is focused on the analysis of pulsatile blood flow in complete idealized 3D bypass models in dependence on three main geometrical parameters (stenosis degree, junction angle and diameter ratio. Assuming the blood to be an incompressible Newtonian fluid, the non-linear system of Navier-Stokes equations is integrated in time by a fully implicit second-order accurate fractional-step method. The space discretization is performed with the help of the cell-centred finite volume method formulated for unstructured tetrahedral grids. In order to model a realistic coronary blood flow, a time-dependent flow rate taken from corresponding literature is considered. For the analysis of obtained numerical results, special emphasis is placed on their comparison in the form of velocity isolines at several selected cross-sections during systolic and diastolic phases. The remainder of this paper is devoted to discussion of walls shear stress distribution and its oscillatory character described by the oscillatory shear index with regard to areas prone to development of intimal hyperplasia or to thrombus formation.

  7. Meta-analysis of peripheral blood apolipoprotein E levels in Alzheimer's disease.

    Directory of Open Access Journals (Sweden)

    Chong Wang

    Full Text Available BACKGROUND: Peripheral blood Apolipoprotein E (ApoE levels have been proposed as biomarkers of Alzheimer's disease (AD, but previous studies on levels of ApoE in blood remain inconsistent. This meta-analysis was designed to re-examine the potential role of peripheral ApoE in AD diagnosis and its potential value as a candidate biomarker. METHODS: We conducted a systematic literature search of MEDLINE, EMBASE, the Cochrane library, and BIOSIS previews for case-control studies measuring ApoE levels in serum or plasma from AD subjects and healthy controls. The pooled weighted mean difference (WMD and 95% confidence interval (CI were used to estimate the association between ApoE levels and AD risk. RESULTS: Eight studies with a total of 2250 controls and 1498 AD cases were identified and analyzed. The pooled WMD from a random-effect model of AD participants compared with the healthy controls was -5.59 mg/l (95% CI: [-8.12, -3.06]. The overall pattern in WMD was not varied by characteristics of study, including age, country, assay method, publication year, and sample type. CONCLUSIONS: Our meta-analysis supports a lowered level of blood ApoE in AD patients, and indicates its potential value as an important risk factor for AD. Further investigation employing standardized assay for ApoE measurement are still warranted to uncover the precise role of ApoE in the pathophysiology of AD.

  8. Design of a prospective clinical study on the agreement between the Continuous GlucoseMonitor, a novel device for CONTinuous ASSessment of blood GLUcose levels, and the RAPIDLab® 1265 blood gas analyser: The CONTASSGLU study

    Directory of Open Access Journals (Sweden)

    Zimmermann Johannes B

    2012-09-01

    Full Text Available Abstract Background Although a device is needed to continuously measure blood glucose levels within an intensive care setting, and several large-scale prospective studies have shown that patients might benefit from intensive insulin, potassium, or glucose therapy during intensive care, no devices are currently available to continuously assess blood glucose levels in critically ill patients. We conceived the study described here to evaluate the clinical use of the Continuous Glucose Monitor (CGM performed via a central vein, and to determine the impact of phenomena, such as drift and shift, on the agreement between the CGM and a RAPIDLab® 1265 blood gas analyser (BGA. Methods/design In the CONTinuous ASSessment of blood GLUcose (CONTASSGLU study, up to 130 patients under intensive care will be fitted with the CGM, an ex vivo device that continuously measures blood glucose and lactate levels. Readings from the device taken 8 h after initial placement and calibration will be compared with values measured by a BGA. For this study, we chose the BGA as it is an established standard point-of-care device, instead of the devices used in certified central laboratories. Nevertheless, we will also independently compare the results from the point-of-care BGA with those determined by a central laboratory-based device. Blood samples will be collected from each patient from the same site in which the CGM will measure blood glucose. Consequently, each participant will serve as their own control, and no randomisation is necessary. The 95% limits of agreement and the corresponding confidence intervals will be calculated and compared with a prespecified clinically acceptable relative difference of 20%. Discussion Several attempts have been made to develop a device to continuously measure blood glucose levels within an intensive care setting or to use the devices that were originally designed for diabetes management, as several of these devices are already

  9. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths

    DEFF Research Database (Denmark)

    NN, NN; Jensen, Gorm Boje

    2007-01-01

    BACKGROUND: Age, sex, and blood pressure could modify the associations of total cholesterol (and its main two fractions, HDL and LDL cholesterol) with vascular mortality. This meta-analysis combined prospective studies of vascular mortality that recorded both blood pressure and total cholesterol at...... were 5000 vascular deaths (3000 IHD, 1000 stroke, 1000 other). Reported associations are with usual cholesterol levels (ie, corrected for the regression dilution bias). FINDINGS: 1 mmol/L lower total cholesterol was associated with about a half (hazard ratio 0.44 [95% CI 0.42-0.48]), a third (0.66 [0...... absolute effects of cholesterol and blood pressure were approximately additive. Of various simple indices involving HDL cholesterol, the ratio total/HDL cholesterol was the strongest predictor of IHD mortality (40% more informative than non-HDL cholesterol and more than twice as informative as total...

  10. X-ray fluorescence analysis of trace elements in blood serum from diabetic patients

    International Nuclear Information System (INIS)

    Full text: The wave dispersive X-ray fluorescence (WDXRF) technique was used for analysis of trace elements in blood serum from 23 nondiabetic healthy individuals (control group) and 58 type II diabetic patients who attended the diabetic clinics. The elements Na, Mg, Al, P, S, Cl, K, Ca, Cr, Mn, Fe, Ni, Cu, Zn, Se, Mo, Cd, Hg and Pb were identified and their concentrations were estimated. Physical basis of used analytical methods, experimental set-up and the procedure of sample preparation are described. The maximum increase in trace elements in the blood samples of the workers compared with the control group was observed for Pb but also for Rb, As and Br

  11. RNA/DNA co-analysis from human menstrual blood and vaginal secretion stains

    DEFF Research Database (Denmark)

    Haas, Claus; Hanson, E; Anjos, M J;

    2014-01-01

    The European DNA Profiling Group (EDNAP) organized a fourth and fifth collaborative exercise on RNA/DNA co-analysis for body fluid identification and STR profiling. The task was to identify dried menstrual blood and vaginal secretion stains using specific RNA biomarkers, and additionally test 3...... simultaneous extraction of RNA and DNA allowed for positive identification of the tissue/fluid source of origin by mRNA profiling as well as a simultaneous identification of the body fluid donor by STR profiling, also from old and compromised casework samples. The results of this and the previous collaborative...... laboratories, using RNA extraction or RNA/DNA co-extraction methods. Two novel menstrual blood mRNA multiplexes were used: MMP triplex (MMP7, MMP10, MMP11) and MB triplex (MSX1, LEFTY2, SFRP4) in conjunction with a housekeeping gene triplex (B2M, UBC, UCE). Two novel mRNA multiplexes and a HBD1 singleplex were...

  12. Environmental variation of arsenic levels in human blood determined by neutron activation analysis

    DEFF Research Database (Denmark)

    Heydorn, Kaj

    1970-01-01

    Arsenic levels in blood plasma and red cells from patients with Blackfoot disease, a peripheral arteriosclerosis endemic to a small area in Taiwan, were studied in relation to healthy individuals from the same and other parts of Taiwan and compared with arsenic levels in a control group from Denm...... in Denmark, which geochemically belongs to a soil zone with less arsenic than Taiwan.......Arsenic levels in blood plasma and red cells from patients with Blackfoot disease, a peripheral arteriosclerosis endemic to a small area in Taiwan, were studied in relation to healthy individuals from the same and other parts of Taiwan and compared with arsenic levels in a control group from...... Denmark. Arsenic was determined by neutron activation analysis with radiochemical separation and re-irradiation yield determination. The precision and accuracy of the results have been carefully evaluated in order to permit quantitative tests for the significance of the observed differences. The results...

  13. Central blood pressure assessment using 24-hour brachial pulse wave analysis

    Directory of Open Access Journals (Sweden)

    Muiesan ML

    2014-10-01

    Full Text Available Maria Lorenza Muiesan, Massimo Salvetti, Fabio Bertacchini, Claudia Agabiti-Rosei, Giulia Maruelli, Efrem Colonetti, Anna Paini Clinica Medica, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy Abstract: This review describes the use of central blood pressure (BP measurements during ambulatory monitoring, using noninvasive devices. The principles of measuring central BP by applanation tonometry and by oscillometry are reported, and information on device validation studies is described. The pathophysiological basis for the differences between brachial and aortic pressure is discussed. The currently available methods for central aortic pressure measurement are relatively accurate, and their use has important clinical implications, such as improving diagnostic and prognostic stratification of hypertension and providing a more accurate assessment of the effect of treatment on BP. Keywords: aortic blood pressure measurements, ambulatory monitoring, pulse wave analysis

  14. Scale Space Methods for Analysis of Type 2 Diabetes Patients' Blood Glucose Values

    Directory of Open Access Journals (Sweden)

    Stein Olav Skrøvseth

    2011-01-01

    Full Text Available We describe how scale space methods can be used for quantitative analysis of blood glucose concentrations from type 2 diabetes patients. Blood glucose values were recorded voluntarily by the patients over one full year as part of a self-management process, where the time and frequency of the recordings are decided by the patients. This makes a unique dataset in its extent, though with a large variation in reliability of the recordings. Scale space and frequency space techniques are suited to reveal important features of unevenly sampled data, and useful for identifying medically relevant features for use both by patients as part of their self-management process, and provide useful information for physicians.

  15. Scale space methods for analysis of type 2 diabetes patients' blood glucose values.

    Science.gov (United States)

    Skrøvseth, Stein Olav; Godtliebsen, Fred

    2011-01-01

    We describe how scale space methods can be used for quantitative analysis of blood glucose concentrations from type 2 diabetes patients. Blood glucose values were recorded voluntarily by the patients over one full year as part of a self-management process, where the time and frequency of the recordings are decided by the patients. This makes a unique dataset in its extent, though with a large variation in reliability of the recordings. Scale space and frequency space techniques are suited to reveal important features of unevenly sampled data, and useful for identifying medically relevant features for use both by patients as part of their self-management process, and provide useful information for physicians. PMID:21436873

  16. Pythia: An object-orientated gas path analysis computer program for general applications

    OpenAIRE

    Escher, P. C.

    1995-01-01

    For both civil and military aero gas turbines, technological advances and high cost of ownership have resulted in considerable interest in advanced maintenance techniques. Some of these techniques are now ready for application to industrial gas turbines. This thesis attempts to give an overview of engine maintenance and engine health monitoring techniques. One way to tackle the high cost is to employ Gas Path Analysis techniques. Gas Path C Analysis helps to identify deteriorated co...

  17. 40 CFR 86.1511 - Exhaust gas analysis system.

    Science.gov (United States)

    2010-07-01

    ... Regulations for Otto-Cycle Heavy-Duty Engines, New Methanol-Fueled Natural Gas-Fueled, and Liquefied Petroleum Gas-Fueled Diesel-Cycle Heavy-Duty Engines, New Otto-Cycle Light-Duty Trucks, and New Methanol-Fueled Natural Gas-Fueled, and Liquefied Petroleum Gas-Fueled Diesel-Cycle Light-Duty Trucks; Idle...

  18. Commercial Hy-Line W-36 pullet and laying hen venous blood gas and chemistry profiles utilizing the portable i-STAT®1 analyzer.

    Science.gov (United States)

    Schaal, T P; Arango, J; Wolc, A; Brady, J V; Fulton, J E; Rubinoff, I; Ehr, I J; Persia, M E; O'Sullivan, N P

    2016-02-01

    Venous blood gas and chemistry reference ranges were determined for commercial Hy-Line W-36 pullets and laying hens utilizing the portable i-STAT®1 analyzer and CG8+ cartridges. A total of 632 samples were analyzed from birds between 4 and 110 wk of age. Reference ranges were established for pullets (4 to 15 wk), first cycle laying hens (20 to 68 wk), and second cycle (post molt) laying hens (70 to 110 wk) for the following traits: sodium (Na mmol/L), potassium (K mmol/L), ionized calcium (iCa mmol/L), glucose (Glu mg/dl), hematocrit (Hct% Packed Cell Volume [PCV]), pH, partial pressure carbon dioxide (PCO2 mm Hg), partial pressure oxygen (PO2 mm Hg), total concentration carbon dioxide (TCO2 mmol/L), bicarbonate (HCO3 mmol/L), base excess (BE mmol/L), oxygen saturation (sO2%), and hemoglobin (Hb g/dl). Data were analyzed using ANOVA to investigate the effect of production status as categorized by bird age. Trait relationships were evaluated by linear correlation and their spectral decomposition. All traits differed significantly among pullets and mature laying hens in both first and second lay cycles. Levels for K, iCa, Hct, pH, TCO2, HCO3, BE, sO2, and Hb differed significantly between first cycle and second cycle laying hens. Many venous blood gas and chemistry parameters were significantly correlated. The first 3 eigenvalues explained ∼2/3 of total variation. The first 2 principal components (PC) explained 51% of the total variation and indicated acid-balance and relationship between blood O2 and CO2. The third PC explained 16% of variation and seems to be related to blood iCa. Establishing reference ranges for pullet and laying hen blood gas and chemistry with the i-STAT®1 handheld unit provides a mechanism to further investigate pullet and layer physiology, evaluate metabolic disturbances, and may potentially serve as a means to select breeder candidates with optimal blood gas or chemistry levels on-farm. PMID:26706355

  19. Comparison of gas chromatographic hyphenated techniques for mercury speciation analysis.

    Science.gov (United States)

    Nevado, J J Berzas; Martín-Doimeadios, R C Rodríguez; Krupp, E M; Bernardo, F J Guzmán; Fariñas, N Rodríguez; Moreno, M Jiménez; Wallace, D; Ropero, M J Patiño

    2011-07-15

    In this study, we evaluate advantages and disadvantages of three hyphenated techniques for mercury speciation analysis in different sample matrices using gas chromatography (GC) with mass spectrometry (GC-MS), inductively coupled plasma mass spectrometry (GC-ICP-MS) and pyrolysis atomic fluorescence (GC-pyro-AFS) detection. Aqueous ethylation with NaBEt(4) was required in all cases. All systems were validated with respect to precision, with repeatability and reproducibility TMAH). No statistically significant differences were found to the certified values (p=0.05). The suitability for water samples analysis with different organic matter and chloride contents was evaluated by recovery experiments in synthetic spiked waters. Absolute detection and quantification limits were in the range of 2-6 pg for GC-pyro-AFS, 1-4 pg for GC-MS, with 0.05-0.21 pg for GC-ICP-MS showing the best limits of detection for the three systems employed. However, all systems are sufficiently sensitive for mercury speciation in environmental samples, with GC-MS and GC-ICP-MS offering isotope analysis capabilities for the use of species-specific isotope dilution analysis, and GC-pyro-AFS being the most cost effective alternative. PMID:21641604

  20. Cause Analysis of Gas Leaks and Methods to Limit Leakage

    OpenAIRE

    Svendsen, Christina

    2014-01-01

    Hydrocarbon gas leaks create potential dangerous situations with major accidents representing worst case scenarios. Smaller gas leaks are also unwanted as they represent risk of escalation and often lead to shut down or reduced production. Small gas leaks also represent in total a significant amount of gas which is detrimental to our atmosphere. Gassco supplies about 20 % of the natural gas consumed in Europe. Economic loss is a direct consequence initiated by shutdown or reduced production, ...

  1. What Drives Natural Gas Consumption in Europe? Analysis and Projections

    OpenAIRE

    Özge Dilaver; Zafer Dilaver; Hunt, Lester C.

    2013-01-01

    Natural gas is an important fuel source for Europe and it is expected to remain so in the near future. The market power of suppliers is an important structural element of the European natural gas market and long-term investment and contracts necessitate reliable projections of natural gas demand. This research attempts to address this need. It investigates the impact of income, real natural gas prices and the underlying energy demand trend (UEDT) on OECD-Europe natural gas consumption by appl...

  2. Analysis of Halogen-Mercury Reactions in Flue Gas

    Energy Technology Data Exchange (ETDEWEB)

    Paula Buitrago; Geoffrey Silcox; Constance Senior; Brydger Van Otten

    2010-01-01

    Oxidized mercury species may be formed in combustion systems through gas-phase reactions between elemental mercury and halogens, such as chorine or bromine. This study examines how bromine species affect mercury oxidation in the gas phase and examines the effects of mixtures of bromine and chlorine on extents of oxidation. Experiments were conducted in a bench-scale, laminar flow, methane-fired (300 W), quartz-lined reactor in which gas composition (HCl, HBr, NO{sub x}, SO{sub 2}) and temperature profile were varied. In the experiments, the post-combustion gases were quenched from flame temperatures to about 350 C, and then speciated mercury was measured using a wet conditioning system and continuous emissions monitor (CEM). Supporting kinetic calculations were performed and compared with measured levels of oxidation. A significant portion of this report is devoted to sample conditioning as part of the mercury analysis system. In combustion systems with significant amounts of Br{sub 2} in the flue gas, the impinger solutions used to speciate mercury may be biased and care must be taken in interpreting mercury oxidation results. The stannous chloride solution used in the CEM conditioning system to convert all mercury to total mercury did not provide complete conversion of oxidized mercury to elemental, when bromine was added to the combustion system, resulting in a low bias for the total mercury measurement. The use of a hydroxylamine hydrochloride and sodium hydroxide solution instead of stannous chloride showed a significant improvement in the measurement of total mercury. Bromine was shown to be much more effective in the post-flame, homogeneous oxidation of mercury than chlorine, on an equivalent molar basis. Addition of NO to the flame (up to 400 ppmv) had no impact on mercury oxidation by chlorine or bromine. Addition of SO{sub 2} had no effect on mercury oxidation by chlorine at SO{sub 2} concentrations below about 400 ppmv; some increase in mercury oxidation

  3. Use of dried blood spots in doping control analysis of anabolic steroid esters.

    Science.gov (United States)

    Tretzel, Laura; Thomas, Andreas; Geyer, Hans; Gmeiner, Günter; Forsdahl, Guro; Pop, Valentin; Schänzer, Wilhelm; Thevis, Mario

    2014-08-01

    Dried blood spot (DBS) sampling, a technique for whole blood sampling on a piece of filter paper, has more than 50-years tradition, particularly in the diagnostic analysis of metabolic disorders in neonatal screening. Due to the minimal invasiveness, straightforwardness, robustness against manipulation and fastness DBS sampling recommends itself as an advantageous technique in doping control analysis. The present approach highlights the development of a screening assay for the analysis of eight anabolic steroid esters (nandrolone phenylpropionate, trenbolone enanthate, testosterone acetate, testosterone cypionate, testosterone isocaproate, testosterone phenylpropionate, testosterone decanoate and testosterone undecanoate) and nandrolone in DBS. The detection of the intact esters allows an unequivocal proof of the administration of conjugates of exogenous testosterone and its derivatives. Precise, specific and linear conditions were obtained by means of liquid chromatography high resolution/high accuracy mass spectrometry. Sensitivity in the low ppb range was accomplished by the preparation of the methyloxime derivatives of the target compounds. Labeled internal standards (d3-nandrolone, d3-nandrolone caproate and d3-nandrolone undecanoate) were applied to compensate for the broad range in chain length of the esters. The assay presented here outlines the application of DBS for the analysis of anabolic steroid esters in doping controls for the first time providing great potential to simplify the proof of exogenous administration of testosterone. PMID:24713476

  4. Advancement and application of gas chromatography isotope ratio mass spectrometry techniques for atmospheric trace gas analysis

    Science.gov (United States)

    Giebel, Brian M.

    2011-12-01

    The use of gas chromatography isotope ratio mass spectrometry (GC-IRMS) for compound specific stable isotope analysis is an underutilized technique because of the complexity of the instrumentation and high analytical costs. However stable isotopic data, when coupled with concentration measurements, can provide additional information on a compounds production, transformation, loss, and cycling within the biosphere and atmosphere. A GC-IRMS system was developed to accurately and precisely measure delta13C values for numerous oxygenated volatile organic compounds having natural and anthropogenic sources. The OVOCs include methanol, ethanol, acetone, methyl ethyl ketone, 2-pentanone, and 3-pentanone. Guided by the requirements for analysis of trace components in air, the GC-IRMS system was developed with the goals of increasing sensitivity, reducing dead-volume and peak band broadening, optimizing combustion and water removal, and decreasing the split ratio to the IRMS. The technique relied on a two-stage preconcentration system, a low-volume capillary reactor and water trap, and a balanced reference gas delivery system. Measurements were performed on samples collected from two distinct sources (i.e. biogenic and vehicle emissions) and ambient air collected from downtown Miami and Everglades National Park. However, the instrumentation and the method have the capability to analyze a variety of source and ambient samples. The measured isotopic signatures that were obtained from source and ambient samples provide a new isotopic constraint for atmospheric chemists and can serve as a new way to evaluate their models and budgets for many OVOCs. In almost all cases, OVOCs emitted from fuel combustion were enriched in 13C when compared to the natural emissions of plants. This was particularly true for ethanol gas emitted in vehicle exhaust, which was observed to have a uniquely enriched isotopic signature that was attributed to ethanol's corn origin and use as an alternative

  5. US Department of Energy investments in natural gas R ampersand D: An analysis of the gas industry proposal

    International Nuclear Information System (INIS)

    The natural gas industry has proposed an increase in the DOE gas R ampersand D budget from about $100 million to about $250 million per year for each of the next 10 years. The proposal includes four programs: natural gas supplies, fuel cells, natural gas vehicles and stationary combustion systems. This paper is a qualitative assessment of the gas industry proposal and recommends a natural gas R ampersand D strategy for the DOE. The methodology is a conceptual framework based on an analysis of market failures and the energy policy objectives of the DOE's (1991) National Energy Strategy. This framework would assist the DOE in constructing an R ampersand D portfolio that achieves energy policy objectives. The natural gas supply program is recommended to the extent that it contributes to energy price stability. Stationary combustion programs are supported on grounds of economic efficiency and environmental quality. The fuel cell program is supported on grounds of environmental quality. The natural gas vehicle program may potentially contribute to environmental quality and energy price stability. The R ampersand D programs in natural gas vehicles and in fuel cells should be complemented with policies that encourage the commercialization and use of the technology, not merely its development

  6. Thermal hydrodynamic analysis of a countercurrent gas centrifuge

    International Nuclear Information System (INIS)

    The influence of the thermal countercurrent on the separative performance of countercurrent centrifuges is treated in this work. The methodology used consists in modeling the gas flow inside the rotor under thermal boundary conditions supplied by the structural thermal model. The gas flow model, also called hydrodynamical model, is based on the Finite Volume Method for cylindrical geometry with azimuthal symmetry. The structural thermal model is based on the Nodal Method and take into account simultaneously, the conduction convection and radiation phenomena. The procedure adopted for this study consisted in the definition of the operational and geometric conditions of a centrifuge which was used as a pattern to the accomplished analysis. This configuration, called 'Standard Centrifuge', was used for the accomplishment of several simulations where the importance of the realistic boundary thermal conditions for the numerical evaluation of the centrifuge separative capacity was evidenced. A selective alteration for the optical properties based on simple engineering procedures was proposed. An improvement of 5% was obtained with this alteration. (author)

  7. Environmental risk analysis for offshore oil and gas activities

    Energy Technology Data Exchange (ETDEWEB)

    Brude, Odd Willy; Aspholm, Ole O.; Rudberg, Anders [Det Norske Veritas (Brazil)

    2008-07-01

    Offshore oil and gas activities always have a risk for environmental impact due to potential accidental releases of oil and gas. The environmental risk can be calculated as a combination of the frequency of such accidents to occur and their environmental consequences in terms of environmental damage to habitats or populations. A method for conducting environmental risk analysis has been in use in Norwegian offshore waters for a decade, with a continuously refinement of methodology over the past years. This paper outlines the principles in the MIRA method and gives examples and discussions regarding use in different environmental compartments. The risk assessment starts with identification of oil spill scenarios with frequencies of potential release rates and spill durations. The next step is to model the oil drift for each accidental oil spill scenario. Drift and fate of oil is modeled probabilistic. Based on the oil spill scenarios and their probability of oil pollution, the potential environmental damage is quantified for each scenario. The endpoint of environmental damage is reduction of a population and the resulting recovery time (in years) for various species and habitats. Environmental risk levels are then evaluated against the operating companies' environmental acceptance criteria. (author)

  8. Gas storage services and regulation in Italy. A Delphi analysis

    International Nuclear Information System (INIS)

    The objective of this paper is to assess to which extent gas market inefficiencies, such as weak competition, import dependence and lack of flexibility tools, affect operation and usage of storage services in Italy in the aftermath of the EU liberalization process. The analysis is supported by the empirical results of a Delphi survey that we have conducted to investigate storage service provision and regulation in Italy. We argue that the Italian storage sector is at a crossroads. The policy-driven phase of liberalization is ending and the market-driven phase has just begun. The former phase has granted fair access to storage, narrowed the likelihood of strategic behaviour by the incumbent and secured residential users against supply disruptions, but it has proved dynamically inefficient. Cost-reflective tariffs and low penalties for unbalances have both lowered incentives to expand the range of flexibility tools and penalized industrial customers demand. The market-driven phase has just started. The expected increase in working capacity and the entry of newcomers in the authorization process for new facilities are a progress towards the commercial use of storage. To this end, however, a further change in gas market design is needed: the creation of a well functioning spot market. (author)

  9. Gas analysis of human exhalation by tunable diode laser spectroscopy

    Science.gov (United States)

    Stepanov, Eugene V.; Moskalenko, Konstantin L.

    1993-02-01

    Results of the application of a tunable diode laser (TDL) to determining the trace gas components of human exhalation are presented. The analyzer is specially developed to measure both carbon oxides (CO and CO2) in expired air. A few results illuminating possible applications of TDLs in high-sensitivity medical diagnostics have been obtained. For nonsmokers, expired concentrations of CO are slightly higher than those in inhaled air. The specific surplus value seems to be independent of the ambient atmospheric CO content. The surplus CO content increases by more than an order of magnitude just after intensive exercises, e.g., jogging. For smokers, the pharmacokinetic of abundant CO removal from the organism could be investigated by this technique, which provides quick and reliable measurements of smoking status. Breath-holding synchronous measurements of CO and CO2 in exhalation demonstrate behavior that is different with breath-holding time. The method seems useful for the investigation of phenomena such as molecular pulmonary diffusion through the alveolar-capillary membrane and an organism's adaptation to oxygen shortage. Prospects for the development and application of diode laser spectroscopy to trace gas analysis in medicine are also discussed.

  10. Risk analysis for a local gas distribution network

    International Nuclear Information System (INIS)

    Cost control and service reliability are popular topics when discussing strategic issues facing local distribution companies (LDCs) in the 1990s. The ability to provide secure and uninterrupted gas service is crucial for growth and company image, both with the public and regulatory agencies. At the same time, the industry is facing unprecedented competition from alternate fuels, and cost control is essential for maintaining a competitive edge in the market. On the surface, it would appear that cost control and service reliability are contradictory terms. Improvement in service reliability should cost something, or does it? Risk analysis can provide the answer from a distribution design perspective. From a gas distribution engineer's perspective, projects such as loops, backfeeds and even valve placement are designed to reduce, minimize and/or eliminate potential customer outages. These projects improve service reliability by acting as backups should a failure occur on a component of the distribution network. These contingency projects are cost-effective but their longterm benefit or true value is under question. Their purpose is to maintain supply to an area in the distribution network in the event of a failure somewhere else. Two phrases, potential customer outages and in the event of failure, identify uncertainty

  11. Differential Scanning Calorimetry and Evolved Gas Analysis of Hydromagnesite

    Science.gov (United States)

    Lauer, H. V., Jr.; Golden, D. C.; Ming, Douglas W.; Boynton, W. V.

    1999-01-01

    Volatile-bearing minerals (e.g., Fe-oxyhydroxides, phyllosilicates, carbonates and sulfates) may be important phases on the surface of Mars. In order to characterize these phases the Thermal and Evolved Gas Analyzer (TEGA) flying on the Mars'98 lander will perform analyses on surface samples from Mars. Hydromagnesite [Mg5(CO3)4(OH)2.4H2O] is considered a good standard mineral to examine as a Mars soil analog component because it evolves both H2O and CO2 at temperatures between 0 and 600 C. Our aim here is to interpret the DSC signature of hydromagnesite under ambient pressure and 20 sccm N2 flow in the range 25 to 600 C. The DSC curve for hydromagnesite under the above conditions consists of three endothermic peaks at temperatures 296, 426, and 548 and one sharp exotherm at 511 C. X-ray analysis of the sample at different stop temperatures suggested that the exotherm corresponded with the formation of crystalline magnesite. The first endotherm was due to dehydration of hydromagnesite, and then the second one was due to the decomposition of carbonate, immediately followed by the formation of magnesite (exotherm) and its decomposition to periclase (last endotherm). Evolution of water and CO2 were consistent with the observed enthalpy changes. A library of such DSC-evolved gas curves for putative Martian minerals are currently being acquired in order to facilitate the interpretation of results obtained by a robotic lander.

  12. Quantitative analysis of carisoprodol and meprobamate in whole blood using benzylcarbamate and deuterated meprobamate as internal standards.

    Science.gov (United States)

    Downey, Delisa; Simons, Kelsie; Ota, Kenji; Kerrigan, Sarah

    2009-06-01

    Carisoprodol and meprobamate are frequently encountered drugs in impaired driving casework. Deuterated internal standards, although preferred, were not available until recently. Earlier published studies report the use of a variety of non-deuterated internal standards, many of which lack the chemical and physical similarities that are desired for quantitative analysis. Carisoprodol and meprobamate were determined in whole blood using solid-phase extraction and gas chromatography-mass spectrometry with benzylcarbamate and meprobamate-d(7) as internal standards. When benzylcarbamate was used as internal standard, the linear ranges for carisoprodol and meprobamate were 0-20 mg/L and 0-40 mg/L, respectively. The linear range increased to 100 mg/L when meprobamate-d(7) was used. Limits of detection for carisoprodol and meprobamate were 0.2 and 0.4 mg/L, respectively, regardless of the internal standard selection. The limit of quantitation for both drugs using either internal standard was 0.4 mg/L. Accuracies using benzylcarbamate and meprobamate-d(7) were 100-106% and 91-100%, respectively. Corresponding values for precision indicated intra-assay coefficients of variation of 2.6-4.3% for benzylcarbamate and 1.0-2.3% for meprobamate-d(7). No carryover was evident at 100 mg/L, the highest concentration tested, and no interferences were observed. Results indicated that either benzylcarbamate or meprobamate-d(7) is a suitable internal standard for quantitative determination of carisoprodol or meprobamate from whole blood. PMID:19671248

  13. Effect of peptides derived from food proteins on blood pressure – a meta-analysis of randomised controlled trials

    OpenAIRE

    Pripp, Are Hugo

    2008-01-01

    Background: Peptides derived from food proteins have in clinical trials shown an effect on blood pressure. Their biological mechanism is mainly due to inhibition of angiotensin-I-converting enzyme (ACE) and thereby regulation of blood pressure through the renin-angiotensin system. A meta-analysis of these trials is needed to better quantify their effect, sources of variation and possible publication bias. Objective: To perform a meta-analysis of placebo-controlled clinical trials on peptides ...

  14. Metaphysics methods development for high temperature gas cooled reactor analysis

    International Nuclear Information System (INIS)

    Gas cooled reactors have been characterized as one of the most promising nuclear reactor concepts in the Generation-IV technology road map. Considerable research has been performed on the design and safety analysis of these reactors. However, the calculational tools being used to perform these analyses are not state-of-the-art and are not capable of performing detailed three-dimensional analyses. This paper presents the results of an effort to develop an improved thermal-hydraulic solver for the pebble bed type high temperature gas cooled reactors. The solution method is based on the porous medium approach and the momentum equation including the modified Ergun's resistance model for pebble bed is solved in three-dimensional geometry. The heat transfer in the pebble bed is modeled considering the local thermal non-equilibrium between the solid and gas, which results in two separate energy equations for each medium. The effective thermal conductivity of the pebble-bed can be calculated both from Zehner-Schluender and Robold correlations. Both the fluid flow and the heat transfer are modeled in three dimensional cylindrical coordinates and can be solved in steady-state and time dependent. The spatial discretization is performed using the finite volume method and the theta-method is used in the temporal discretization. A preliminary verification was performed by comparing the results with the experiments conducted at the SANA test facility. This facility is located at the Institute for Safety Research and Reactor Technology (ISR), Julich, Germany. Various experimental cases are modeled and good agreement in the gas and solid temperatures is observed. An on-going effort is to model the control rod ejection scenarios as described in the OECD/NEA/NSC PBMR-400 benchmark problem. In order to perform these analyses PARCS reactor simulator code will be coupled with the new thermal-hydraulic solver. Furthermore, some of the other anticipated accident scenarios in the benchmark

  15. Alcohol-positive multiple trauma patients with and without blood transfusion: an outcome analysis

    Directory of Open Access Journals (Sweden)

    Stuttmann Ralph

    2009-03-01

    Full Text Available Abstract Background Blood transfusion is a common therapy for multiple trauma patients, and is often performed soon after hospital admission. It is unclear whether the need for a blood transfusion in multiply injured patients presenting with a positive blood alcohol concentration (BAC is associated with increased morbidity/mortality, since their risk behavior differs significantly from patients with a negative BAC. In this study, we evaluated the role of blood transfusion in the treatment of BAC-positive multiple trauma patients. Patients In a three-year period, 164 patients at a single trauma center presented with a positive BAC, and 145 met the inclusion criteria for further evaluation and regression analysis. We compared patients who were transfused (n = 76 with those who were not transfused (n = 69. Results In both groups, the most common causes of trauma were traffic accidents and falls. Most patients were admitted to the hospital from the scene of the accident (77.2% and were male (89.0%. Transfused patients had a lower GCS (p ≤ .001 and her ISS (p ≤ .001, were more likely to have severe head injuries (p ≤ .001, tended to have higher BACs (p = .053, had lower hemoglobin levels and prothrombin times in the first 24 hours (p ≤ .001, had lower lactate levels, had higher rates of intubation (p ≤ .001 and ICU admission, and had longer ICU stays and artificial ventilation times (p ≤ .001. Mortality was significantly higher in transfused patients (n = 15 vs. n = 3, p ≤ .001. Non-survivors were more likely to have severe head injuries; be intubated and ventilated; be older; have higher ISS scores, lactate levels, and numbers of transfusions in the first 24 hours; and have lower GCS scores, hemoglobin measurements, and prothrombin levels. In a binary logistic regression model, only age (p = .009 and ISS (p = .004 independently predicted mortality. Conclusion In our single-center study, the BAC of multiple trauma patients and the

  16. Percolation analysis of a disordered spinor Bose gas

    Science.gov (United States)

    Nabi, Sk Noor; Basu, Saurabh

    2016-06-01

    We study the effects of an on-site disorder potential in a gas of spinor (spin-1) ultracold atoms loaded in an optical lattice corresponding to both ferromagnetic and antiferromagnetic spin-dependent interactions. Starting with a disordered spinor Bose–Hubbard model (SBHM) on a two-dimensional square lattice, we observe the appearance of a Bose glass phase using the fraction of the lattice sites having finite superfluid order parameter and non integer local densities as an indicator. A precise distinction between three different types of phases namely, superfluid, Mott insulator and Bose glass is done via a percolation analysis thereby demonstrating that a reliable enumeration of phases is possible at particular values of the parameters of the SBHM. Finally, we present the phase diagram based on the above information for both antiferromagnetic and ferromagnetic interactions.

  17. Greenhouse gas emission inventory based on full energy chain analysis

    International Nuclear Information System (INIS)

    Methodology, characteristics, features and results obtained for greenhouse gases within the recent Swiss LCA study 'Environmental Life-Cycle Inventories of Energy Systems' are presented. The focus of the study is on existing average Full Energy Chains (FENCHs) in the electricity generation mixes in Europe and in Switzerland. The systems, including coal (hard coal and lignite), oil, natural gas, nuclear and hydro, are discussed one by one as well as part of the electricity mixes. Photovoltaic systems are covered separately since they are not included in the electricity mixes. A sensitivity analysis on methane leakage during long-range transport via pipeline is shown. Whilst within the current study emissions are not attributed to specific countries, the main sectors contributing to the total GHGs emissions calculated for the various FENCHs are specified. (author). 10 refs, 10 figs, 9 tabs

  18. Quantifying tight-gas sandstone permeability via critical path analysis

    Science.gov (United States)

    Ghanbarian, Behzad; Torres-Verdín, Carlos; Skaggs, Todd H.

    2016-06-01

    Rock permeability has been actively investigated over the past several decades by the geosciences community. However, its accurate estimation still presents significant technical challenges, particularly in spatially complex rocks. In this short communication, we apply critical path analysis (CPA) to estimate permeability in porous rocks from measured mercury intrusion porosimetry and electrical conductivity data. Theoretical estimations of various CPA-based models are then compared to experimental measurements using eighteen tight-gas sandstones. Except for two of the samples, we find permeability estimations performed with the Skaggs model (assuming pore diameter independent of its length) more accurate than other models, within a factor of two of the measured permeabilities. We discuss some plausible sources of the uncertainties.

  19. Venus lower atmospheric composition - Analysis by gas chromatography

    Science.gov (United States)

    Oyama, V. I.; Carle, G. C.; Woeller, F.; Pollack, J. B.

    1979-01-01

    The first gas chromatographic analysis of the lower atmosphere of Venus is reported. Three atmospheric samples were analyzed. The third of these samples showed carbon dioxide (96.4 percent), molecular nitrogen (3.41 percent), water vapor (0.135 percent), molecular oxygen (69.3 ppm), argon (18.6 ppm), neon (4.31 ppm), and sulfur dioxide (186 ppm). The amounts of water vapor and sulfur dioxide detected are roughly compatible with the requirements of greenhouse models of the high surface temperature of Venus. The large positive gradient of sulfur dioxide, molecular oxygen, and water vapor from the cloud tops to their bottoms, as implied by Earth-based observations and these results, gives added support for the presence of major quantities of aqueous sulfuric acid in the clouds. A comparison of the inventory of inert gases found in the atmospheres of Venus, Earth, and Mars suggests that these components are due to outgassing from the planetary interiors.

  20. Sensitivity analysis aimed at blood vessels detection using interstitial optical tomography during brain needle biopsy procedures.

    Science.gov (United States)

    Pichette, Julien; Goyette, Andréanne; Picot, Fabien; Tremblay, Marie-Andrée; Soulez, Gilles; Wilson, Brian C; Leblond, Frédéric

    2015-11-01

    A brain needle biopsy procedure is performed for suspected brain lesions in order to sample tissue that is subsequently analysed using standard histopathology techniques. A common complication resulting from this procedure is brain hemorrhaging from blood vessels clipped off during tissue extraction. Interstitial optical tomography (iOT) has recently been introduced by our group as a mean to assess the presence of blood vessels in the vicinity of the needle. The clinical need to improve safety requires the detection of blood vessels within 2 mm from the outer surface of the needle, since this distance is representative of the volume of tissue that is aspirated durirng tissue extraction. Here, a sensitivity analysis is presented to establish the intrinsic detection limits of iOT based on simulations and experiments using brain tissue phantoms. It is demonstrated that absorbers can be detected with diameters >300 μm located up to >2 mm from the biopsy needle core for bulk optical properties consistent with brain tissue. PMID:26600990

  1. Multimodal Pressure-Flow Analysis: Application of Hilbert Huang Transform in Cerebral Blood Flow Regulation

    Directory of Open Access Journals (Sweden)

    Vera Novak

    2008-06-01

    Full Text Available Quantification of nonlinear interactions between two nonstationary signals presents a computational challenge in different research fields, especially for assessments of physiological systems. Traditional approaches that are based on theories of stationary signals cannot resolve nonstationarity-related issues and, thus, cannot reliably assess nonlinear interactions in physiological systems. In this review we discuss a new technique called multimodal pressure flow (MMPF method that utilizes Hilbert-Huang transformation to quantify interaction between nonstationary cerebral blood flow velocity (BFV and blood pressure (BP for the assessment of dynamic cerebral autoregulation (CA. CA is an important mechanism responsible for controlling cerebral blood flow in responses to fluctuations in systemic BP within a few heart-beats. The MMPF analysis decomposes BP and BFV signals into multiple empirical modes adaptively so that the fluctuations caused by a specific physiologic process can be represented in a corresponding empirical mode. Using this technique, we showed that dynamic CA can be characterized by specific phase delays between the decomposed BP and BFV oscillations, and that the phase shifts are significantly reduced in hypertensive, diabetics and stroke subjects with impaired CA. Additionally, the new technique can reliably assess CA using both induced BP/BFV oscillations during clinical tests and spontaneous BP/BFV fluctuations during resting conditions.

  2. A Rapid and Low-Cost Nonlithographic Method to Fabricate Biomedical Microdevices for Blood Flow Analysis

    Directory of Open Access Journals (Sweden)

    Elmano Pinto

    2014-12-01

    Full Text Available Microfluidic devices are electrical/mechanical systems that offer the ability to work with minimal sample volumes, short reactions times, and have the possibility to perform massive parallel operations. An important application of microfluidics is blood rheology in microdevices, which has played a key role in recent developments of lab-on-chip devices for blood sampling and analysis. The most popular and traditional method to fabricate these types of devices is the polydimethylsiloxane (PDMS soft lithography technique, which requires molds, usually produced by photolithography. Although the research results are extremely encouraging, the high costs and time involved in the production of molds by photolithography is currently slowing down the development cycle of these types of devices. Here we present a simple, rapid, and low-cost nonlithographic technique to create microfluidic systems for biomedical applications. The results demonstrate the ability of the proposed method to perform cell free layer (CFL measurements and the formation of microbubbles in continuous blood flow.

  3. A rapid analysis of plasma/serum ethylene and propylene glycol by headspace gas chromatography.

    Science.gov (United States)

    Ehlers, Alexandra; Morris, Cory; Krasowski, Matthew D

    2013-12-01

    A rapid headspace-gas chromatography (HS-GC) method was developed for the analysis of ethylene glycol and propylene glycol in plasma and serum specimens using 1,3-propanediol as the internal standard. The method employed a single-step derivitization using phenylboronic acid, was linear to 200 mg/dL and had a lower limit of quantitation of 1 mg/dL suitable for clinical analyses. The analytical method described allows for laboratories with HS-GC instrumentation to analyze ethanol, methanol, isopropanol, ethylene glycol, and propylene glycol on a single instrument with rapid switch-over from alcohols to glycols analysis. In addition to the novel HS-GC method, a retrospective analysis of patient specimens containing ethylene glycol and propylene glycol was also described. A total of 36 patients ingested ethylene glycol, including 3 patients who presented with two separate admissions for ethylene glycol toxicity. Laboratory studies on presentation to hospital for these patients showed both osmolal and anion gap in 13 patients, osmolal but not anion gap in 13 patients, anion but not osmolal gap in 8 patients, and 1 patient with neither an osmolal nor anion gap. Acidosis on arterial blood gas was present in 13 cases. Only one fatality was seen; this was a patient with initial serum ethylene glycol concentration of 1282 mg/dL who died on third day of hospitalization. Propylene glycol was common in patients being managed for toxic ingestions, and was often attributed to iatrogenic administration of propylene glycol-containing medications such as activated charcoal and intravenous lorazepam. In six patients, propylene glycol contributed to an abnormally high osmolal gap. The common presence of propylene glycol in hospitalized patients emphasizes the importance of being able to identify both ethylene glycol and propylene glycol by chromatographic methods. PMID:23741644

  4. Quantitative Analysis of Trace Chromium in Blood Samples. Combination of the Advanced Oxidation Process with Catalytic Adsorptive Stripping Voltammetry

    OpenAIRE

    Yong, Li; Armstrong, Kristie C.; Dansby-Sparks, Royce N.; Carrington, Nathan A.; Chambers, James Q.; Xue, Zi-Ling

    2006-01-01

    A new method for pretreating blood samples for trace Cr analysis is described. The Advanced Oxidation Process (AOP with H2O2 and 5.5-W irradiation for 60 min) is used to remove biological/organic species for subsequent analysis. Prior to the AOP pretreatment, acid (HNO3) is used at pH 3.0 to inhibit the enzyme catalase in the blood samples. Catalytic Adsorptive Stripping Voltammetry (CAdSV) at a bismuth film electrode (BiFE) gives Cr concentration of 6.0 ± 0.3 ppb in the blood samples. This c...

  5. Technology and Greenhouse Gas Emissions: An IntegratedScenario Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Koomey, J.G.; Latiner, S.; Markel, R.J.; Marnay, C.; Richey, R.C.

    1998-09-01

    This report describes an analysis of possible technology-based scenarios for the U.S. energy system that would result in both carbon savings and net economic benefits. We use a modified version of the Energy Information Administration's National Energy Modeling System (LBNL-NEMS) to assess the potential energy, carbon, and bill savings from a portfolio of carbon saving options. This analysis is based on technology resource potentials estimated in previous bottom-up studies, but it uses the integrated LBNL-NEMS framework to assess interactions and synergies among these options. The analysis in this paper builds on previous estimates of possible "technology paths" to investigate four major components of an aggressive greenhouse gas reduction strategy: (1) the large scale implementation of demand-side efficiency, comparable in scale to that presented in two recent policy studies on this topic; (2) a variety of "alternative" electricity supply-side options, including biomass cofiring, extension of the renewable production tax credit for wind, increased industrial cogeneration, and hydropower refurbishment. (3) the economic retirement of older and less efficient existing fossil-find power plants; and (4) a permit charge of $23 per metric ton of carbon (1996 $/t),l assuming that carbon trading is implemented in the US, and that the carbon permit charge equilibrates at this level. This level of carbon permit charge, as discussed later in the report, is in the likely range for the Clinton Administration's position on this topic.

  6. Uncertainty of Blood Alcohol Concentration (BAC Results as Related to Instrumental Conditions: Optimization and Robustness of BAC Analysis Headspace Parameters

    Directory of Open Access Journals (Sweden)

    Haleigh A. Boswell

    2015-12-01

    Full Text Available Analysis of blood alcohol concentration is a routine analysis performed in many forensic laboratories. This analysis commonly utilizes static headspace sampling, followed by gas chromatography combined with flame ionization detection (GC-FID. Studies have shown several “optimal” methods for instrumental operating conditions, which are intended to yield accurate and precise data. Given that different instruments, sampling methods, application specific columns and parameters are often utilized, it is much less common to find information on the robustness of these reported conditions. A major problem can arise when these “optimal” conditions may not also be robust, thus producing data with higher than desired uncertainty or potentially inaccurate results. The goal of this research was to incorporate the principles of quality by design (QBD in the adjustment and determination of BAC (blood alcohol concentration instrumental headspace parameters, thereby ensuring that minor instrumental variations, which occur as a matter of normal work, do not appreciably affect the final results of this analysis. This study discusses both the QBD principles as well as the results of the experiments, which allow for determination of more favorable instrumental headspace conditions. Additionally, method detection limits will also be reported in order to determine a reporting threshold and the degree of uncertainty at the common threshold value of 0.08 g/dL. Furthermore, the comparison of two internal standards, n-propanol and t-butanol, will be investigated. The study showed that an altered parameter of 85 °C headspace oven temperature and 15 psi headspace vial pressurization produces the lowest percent relative standard deviation of 1.3% when t-butanol is implemented as an internal standard, at least for one very common platform. The study also showed that an altered parameter of 100 °C headspace oven temperature and 15-psi headspace vial pressurization

  7. Trace element analysis of human blood serum by neutron activation analysis

    International Nuclear Information System (INIS)

    An attempt was made to determine if there is any correlation between trace element concentrations in human blood serum and some specific diseases. The serum samples of the patients suffering from cancer, Down syndrome, and Banti syndrome were analyzed by the neutron activation method and compared with the trace element concentrations observed among clinically healthy men. The cancer patients had concentrations in Rb, Mn, Fe, Co, Cu, Zn, Al and Se below normal. The Down syndrome patients were found to have similar deficiencies in Cr, Mn, Fe, Co, Zn, Cu and Sb. (author)

  8. Arterial blood pressure measurement and pulse wave analysis--their role in enhancing cardiovascular assessment.

    Science.gov (United States)

    Avolio, Alberto P; Butlin, Mark; Walsh, Andrew

    2010-01-01

    The most common method of clinical measurement of arterial blood pressure is by means of the cuff sphygmomanometer. This instrument has provided fundamental quantitative information on arterial pressure in individual subjects and in populations and facilitated estimation of cardiovascular risk related to levels of blood pressure obtained from the brachial cuff. Although the measurement is taken in a peripheral limb, the values are generally assumed to reflect the pressure throughout the arterial tree in large conduit arteries. Since the arterial pressure pulse becomes modified as it travels away from the heart towards the periphery, this is generally true for mean and diastolic pressure, but not for systolic pressure, and so pulse pressure. The relationship between central and peripheral pulse pressure depends on propagation characteristics of arteries. Hence, while the sphygmomanometer gives values of two single points on the pressure wave (systolic and diastolic pressure), there is additional information that can be obtained from the time-varying pulse waveform that enables an improved quantification of the systolic load on the heart and other central organs. This topical review will assess techniques of pressure measurement that relate to the use of the cuff sphygmomanometer and to the non-invasive registration and analysis of the peripheral and central arterial pressure waveform. Improved assessment of cardiovascular function in relation to treatment and management of high blood pressure will result from future developments in the indirect measurement of arterial blood pressure that involve the conventional cuff sphygmomanometer with the addition of information derived from the peripheral arterial pulse. PMID:19940350

  9. Numerical Analysis of Blood Damage Potential of the HeartMate II and HeartWare HVAD Rotary Blood Pumps.

    Science.gov (United States)

    Thamsen, Bente; Blümel, Bastian; Schaller, Jens; Paschereit, Christian O; Affeld, Klaus; Goubergrits, Leonid; Kertzscher, Ulrich

    2015-08-01

    Implantable left ventricular assist devices (LVADs) became the therapy of choice in treating end-stage heart failure. Although survival improved substantially and is similar in currently clinically implanted LVADs HeartMate II (HM II) and HeartWare HVAD, complications related to blood trauma are frequently observed. The aim of this study was to compare these two pumps regarding their potential blood trauma employing computational fluid dynamics. High-resolution structured grids were generated for the pumps. Newtonian flow was calculated, solving Reynolds-averaged Navier-Stokes equations with a sliding mesh approach and a k-ω shear stress transport turbulence model for the operating point of 4.5 L/min and 80 mm Hg. The pumps were compared in terms of volumes subjected to certain viscous shear stress thresholds, below which no trauma was assumed (von Willebrand factor cleavage: 9 Pa, platelet activation: 50 Pa, and hemolysis: 150 Pa), and associated residence times. Additionally, a hemolysis index was calculated based on a Eulerian transport approach. Twenty-two percent of larger volumes above 9 Pa were observed in the HVAD; above 50 Pa and 150 Pa the differences between the two pumps were marginal. Residence times were higher in the HVAD for all thresholds. The hemolysis index was almost equal for the HM II and HVAD. Besides the gap regions in both pumps, the inlet regions of the rotor and diffuser blades have a high hemolysis production in the HM II, whereas in the HVAD, the volute tongue is an additional site for hemolysis production. Thus, in this study, the comparison of the HM II and the HVAD using numerical methods indicated an overall similar tendency to blood trauma in both pumps. However, influences of turbulent shear stresses were not considered and effects of the pivot bearing in the HM II were not taken into account. Further in vitro investigations are required. PMID:26234447

  10. Performance analysis for underground gas storage reservoir in depleted gas field

    Institute of Scientific and Technical Information of China (English)

    谭羽飞; 陈家新

    2002-01-01

    The construction of underground natural gas storage is one of the most reasonable and effective ways for basically surmounting city seasonal peak shaving and stabilizing peak waving. Owing to the heterogeneity of geological structure used as underground natural gas storage and different capacities of storing and transmitting fluid in reservoir, it is necessary make a reasonable proration for each member of the injection and production wells within the storage during peak shaving. In this paper, through analyzing the injection-production performance characteristics of the underground natural gas storage in depleted gas field, an accurate mathematical model of the underground gas storage of depleted gas field is set up; characteristics of the storage performance and permeating processes were studied,history processes of underground gas storage were stimulated and major influence factors were analyzed. Specific and typical examples from actural data are included to demonstrate the relevance of the method to simulation of storage operation.

  11. UK data and analysis for shale gas prospectivity

    OpenAIRE

    Smith, N.; Turner, P.; Williams, G.

    2010-01-01

    Organic-rich shale contains significant amounts of gas held within fractures and micropores and adsorbed onto organic matter. In the USA shale gas extracted from regionally extensive units such as the Barnett Shale currently accounts for 6% of gas production and is likely to reach 30% by 2015. Shale gas prospectivity is controlled by the amount and type of organic matter held in the shale, its thermal maturity, burial history, microporosity and fracture spacing and orientation. Potential targ...

  12. Analysis of gas-piston engine`s outlook

    OpenAIRE

    Безюков, Олег Константинович; Жуков, Владимир Анатольевич; Ященко, О. И.

    2014-01-01

    Comparative characteristics of different kinds of gas fuel for internal combustion engines are given in the article. Experience of use gas-fuel for engines was analysed. Prospects of widening gas-piston engines’ employment into conditions of rising ecological requirements for power plant of means of transport are shown. The appraisal of influence of gas-fuel’s using by index of working process, economical and ecological characteristics of engines is presented. Problems, which must be solved f...

  13. Advantage in Bright-blood and Black-blood Magnetic Resonance Imaging with High-resolution for Analysis of Carotid Atherosclerotic Plaques

    Directory of Open Access Journals (Sweden)

    Mei Li

    2015-01-01

    Full Text Available Background: About 50% of the cerebral ischemia events are induced by intracranial and extracranial atherosclerosis. This study aimed to evaluate the feasibility and accuracy for displaying atherosclerotic plaques in carotid arteries and analyzing their ingredients by using high-resolution new magnetic resonance imaging (MRI techniques. Methods: Totally, 49 patients suspected of extracranial carotid artery stenosis were subjected to cranial MRI scan and magnetic resonance angiography (MRA examination on carotid arteries, and high-resolution bright-blood and black-blood MRI analysis was carried out within 1 week. Digital subtraction angiography (DSA examination was carried out for 16 patients within 1 month. Results: Totally, 103 plaques were detected in the 49 patients, which were characterized by localized or diffusive thickening of the vessel wall, with the intrusion of crescent-shaped abnormal signal into lumens. Fibrous cap was displayed as isointensity in T1-weighted image (T1WI and hyperintensities in proton density weighted image (PDWI and T2-weighted image (T2WI, lipid core was displayed as isointensity or slight hyperintensities in T1WI, isointensity, hyperintensities or hypointensity in PDWI, and hypointensity in T2WI. Calcification in plaques was detected in 11 patients. Eight patients were detected with irregular plaque surface or ulcerative plaques, which were characterized by irregular intravascular space surface in the black-blood sequences, black hypointensity band was not detected in three-dimensional time-of-flight, or the hypointensity band was not continuous, and intrusion of hyperintensities into plaques can be detected. Bright-blood and black-blood techniques were highly correlated with the diagnosis of contrast-enhanced MRA in angiostenosis degree, Rs = 0.97, P < 0.001. In comparison to DSA, the sensitivity, specificity, and accuracy of MRI diagnosis of stenosis for ≥50% were 88.9%, 100%, and 97.9%, respectively

  14. Analysis of perfluoroalkyl substances in cord blood by turbulent flow chromatography coupled to tandem mass spectrometry

    International Nuclear Information System (INIS)

    A fast on-line analytical method based on turbulent flow chromatography (TFC) in combination with tandem mass spectrometry has been applied for the first time for the analysis of eighteen perfluoroalkyl substances (PFASs), in cord blood. A simple and rapid sample pre-treatment was optimised consisting on protein precipitation of 100 μL of sample with acetonitrile (1:1) followed by centrifugation during 10 min. The method was adapted to be sensitive enough and robust with minimum sample injection volume requirements (20 μL). The optimised methodology presented method limits of detection (MLOD) between 0.031 and 0.76 μg/L, detection capabilities (CCα) in the range between 0.005 and 0.99 μg/L and decision limits (CCβ) ranging from 0.006 to 1.16 μg/L. The recoveries in blank blood were calculated by spiking experiments with a mixture of 18 PFASs and established between 70 and 126% for most of compounds. Isotopic dilution was carried out for quantification of selected analytes. In-house validation of this new approach was carried out according to the requirements in the 2002/657/EC Decision. Finally the good applicability of this new approach was proved by the analysis of 60 cord blood samples from two different Mediterranean cities, Barcelona (Spain) and Heraklion (Greece). Ions perfluorohexanesulfonate (PFHxS) and perfluorooctanesulfonate (PFOS) were found at highest concentration and the more frequently compounds were PFHxS, PFOS and perfluorooctanoic acid (PFOA). The newly developed method proved to be suitable for large-scale epidemiologic studies, and to the data on PFASs exposure during pregnancy. -- Highlights: ► An on-line method has been developed for the analysis of 18 perfluoroalkyl substances. ► The method is based on turbulent flow chromatography tandem mass spectrometry. ► The method was applied in 60 cord blood samples from 2 Mediterranean cities. ► Acidic compounds were more frequently found and the method was proved to be suitable for

  15. Analysis of perfluoroalkyl substances in cord blood by turbulent flow chromatography coupled to tandem mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Llorca, Marta; Perez, Francisca [Department of Environmental Chemistry, IDAEA-CSIC, Barcelona (Spain); Farre, Marinella, E-mail: mfuqam@cid.csic.es [Department of Environmental Chemistry, IDAEA-CSIC, Barcelona (Spain); Agramunt, Silvia [Centre for Research in Environmental Epidemiology (CREAL), Barcelona (Spain); IMIM (Hospital del Mar Research Institute), Barcelona (Spain); Kogevinas, Manolis [Centre for Research in Environmental Epidemiology (CREAL), Barcelona (Spain); IMIM (Hospital del Mar Research Institute), Barcelona (Spain); CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona (Spain); National School of Public Health, Athens (Greece); Barcelo, Damia [Department of Environmental Chemistry, IDAEA-CSIC, Barcelona (Spain); Catalan Institute for Water Research (ICRA), Girona (Spain); King Saud University, Riyadh (Saudi Arabia)

    2012-09-01

    A fast on-line analytical method based on turbulent flow chromatography (TFC) in combination with tandem mass spectrometry has been applied for the first time for the analysis of eighteen perfluoroalkyl substances (PFASs), in cord blood. A simple and rapid sample pre-treatment was optimised consisting on protein precipitation of 100 {mu}L of sample with acetonitrile (1:1) followed by centrifugation during 10 min. The method was adapted to be sensitive enough and robust with minimum sample injection volume requirements (20 {mu}L). The optimised methodology presented method limits of detection (MLOD) between 0.031 and 0.76 {mu}g/L, detection capabilities (CC{alpha}) in the range between 0.005 and 0.99 {mu}g/L and decision limits (CC{beta}) ranging from 0.006 to 1.16 {mu}g/L. The recoveries in blank blood were calculated by spiking experiments with a mixture of 18 PFASs and established between 70 and 126% for most of compounds. Isotopic dilution was carried out for quantification of selected analytes. In-house validation of this new approach was carried out according to the requirements in the 2002/657/EC Decision. Finally the good applicability of this new approach was proved by the analysis of 60 cord blood samples from two different Mediterranean cities, Barcelona (Spain) and Heraklion (Greece). Ions perfluorohexanesulfonate (PFHxS) and perfluorooctanesulfonate (PFOS) were found at highest concentration and the more frequently compounds were PFHxS, PFOS and perfluorooctanoic acid (PFOA). The newly developed method proved to be suitable for large-scale epidemiologic studies, and to the data on PFASs exposure during pregnancy. -- Highlights: Black-Right-Pointing-Pointer An on-line method has been developed for the analysis of 18 perfluoroalkyl substances. Black-Right-Pointing-Pointer The method is based on turbulent flow chromatography tandem mass spectrometry. Black-Right-Pointing-Pointer The method was applied in 60 cord blood samples from 2 Mediterranean cities

  16. Relating landfill gas emissions to atmospheric pressure using numerical modeling and state-space analysis

    DEFF Research Database (Denmark)

    Poulsen, T.G.; Christophersen, Mette; Moldrup, P.; Kjeldsen, Peter

    2003-01-01

    were applied: (I) State-space analysis was used to identify relations between gas flux and short-term (hourly) variations in atmospheric pressure. (II) A numerical gas transport model was fitted to the data and used to quantify short-term impacts of variations in atmospheric pressure, volumetric soil-water...... content, soil gas permeability, soil gas diffusion coefficients, and biological CH4 degradation rate upon landfill gas concentration and fluxes in the soil. Fluxes and concentrations were found to be most sensitive to variations in volumetric soil water content, atmospheric pressure variations and gas...

  17. Analysis of Maisotsenko open gas turbine power cycle with a detailed air saturator model

    International Nuclear Information System (INIS)

    Highlights: • Developed an accurate air saturator model. • Performed sensitivity analysis for Maisotsenko gas turbine cycle (MGTC). • Performed comparative analysis for MGTC and simple gas turbine with reheat (SGTR) and humid air turbine (HAT). • MGTC has higher efficiency and specific work output with at high compressor pressure ratio. • Optimum air saturator water mass flow rate is calculated. - Abstract: With ever increasing cost of fossil fuels and natural gas, the improvement in gas turbine power cycle efficiency is needed due to the tremendous savings in fuel consumption. Water/steam injection is considered as one of the most popular power augmentation techniques because of its significant impact on the gas turbine performance. One of the recently suggested evaporative gas turbine cycles is the Maisotsenko open cycle for gas turbine power generation. In this paper, detailed thermodynamic analysis of this cycle is investigated with a thorough air saturator model. A comparative analysis is carried out to signify the advantages and disadvantages of Maisotsenko gas turbine cycle (MGTC) as compared with humid air gas turbine cycles. MGTC performance is evaluated based on a simple recuperated gas turbine cycle. In addition, sensitivity analysis is performed to investigate the effect of different operating parameters on the overall cycle performance. Finally, integrating an air saturator instead of a conventional heat exchanger in recuperated gas turbine cycles enhances the power plant performance such that an efficiency enhancement of 7% points and net specific work output augmentation of 44.4% are obtained

  18. Weighted gene co-expression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients

    Directory of Open Access Journals (Sweden)

    DeYoung Joseph

    2009-08-01

    Full Text Available Abstract Background Amyotrophic Lateral Sclerosis (ALS is a lethal disorder characterized by progressive degeneration of motor neurons in the brain and spinal cord. Diagnosis is mainly based on clinical symptoms, and there is currently no therapy to stop the disease or slow its progression. Since access to spinal cord tissue is not possible at disease onset, we investigated changes in gene expression profiles in whole blood of ALS patients. Results Our transcriptional study showed dramatic changes in blood of ALS patients; 2,300 probes (9.4% showed significant differential expression in a discovery dataset consisting of 30 ALS patients and 30 healthy controls. Weighted gene co-expression network analysis (WGCNA was used to find disease-related networks (modules and disease related hub genes. Two large co-expression modules were found to be associated with ALS. Our findings were replicated in a second (30 patients and 30 controls and third dataset (63 patients and 63 controls, thereby demonstrating a highly significant and consistent association of two large co-expression modules with ALS disease status. Ingenuity Pathway Analysis of the ALS related module genes implicates enrichment of functional categories related to genetic disorders, neurodegeneration of the nervous system and inflammatory disease. The ALS related modules contain a number of candidate genes possibly involved in pathogenesis of ALS. Conclusion This first large-scale blood gene expression study in ALS observed distinct patterns between cases and controls which may provide opportunities for biomarker development as well as new insights into the molecular mechanisms of the disease.

  19. Methodology for in situ gas sampling, transport and laboratory analysis of gases from stranded cetaceans.

    Science.gov (United States)

    Bernaldo de Quirós, Yara; González-Díaz, Oscar; Saavedra, Pedro; Arbelo, Manuel; Sierra, Eva; Sacchini, Simona; Jepson, Paul D; Mazzariol, Sandro; Di Guardo, Giovanni; Fernández, Antonio

    2011-01-01

    Gas-bubble lesions were described in cetaceans stranded in spatio-temporal concordance with naval exercises using high-powered sonars. A behaviourally induced decompression sickness-like disease was proposed as a plausible causal mechanism, although these findings remain scientifically controversial. Investigations into the constituents of the gas bubbles in suspected gas embolism cases are highly desirable. We have found that vacuum tubes, insulin syringes and an aspirometer are reliable tools for in situ gas sampling, storage and transportation without appreciable loss of gas and without compromising the accuracy of the analysis. Gas analysis is conducted by gas chromatography in the laboratory. This methodology was successfully applied to a mass stranding of sperm whales, to a beaked whale stranded in spatial and temporal association with military exercises and to a cetacean chronic gas embolism case. Results from the freshest animals confirmed that bubbles were relatively free of gases associated with putrefaction and consisted predominantly of nitrogen. PMID:22355708

  20. Methodology for in situ gas sampling, transport and laboratory analysis of gases from stranded cetaceans

    Science.gov (United States)

    de Quirós, Yara Bernaldo; González-Díaz, Óscar; Saavedra, Pedro; Arbelo, Manuel; Sierra, Eva; Sacchini, Simona; Jepson, Paul D.; Mazzariol, Sandro; di Guardo, Giovanni; Fernández, Antonio

    2011-12-01

    Gas-bubble lesions were described in cetaceans stranded in spatio-temporal concordance with naval exercises using high-powered sonars. A behaviourally induced decompression sickness-like disease was proposed as a plausible causal mechanism, although these findings remain scientifically controversial. Investigations into the constituents of the gas bubbles in suspected gas embolism cases are highly desirable. We have found that vacuum tubes, insulin syringes and an aspirometer are reliable tools for in situ gas sampling, storage and transportation without appreciable loss of gas and without compromising the accuracy of the analysis. Gas analysis is conducted by gas chromatography in the laboratory. This methodology was successfully applied to a mass stranding of sperm whales, to a beaked whale stranded in spatial and temporal association with military exercises and to a cetacean chronic gas embolism case. Results from the freshest animals confirmed that bubbles were relatively free of gases associated with putrefaction and consisted predominantly of nitrogen.

  1. Hemograma e perfil bioquímico sérico, inclusive hemogasométrico, de bezerros infectados experimentalmente com Salmonella Dublin Blood cell counts and serum biochemical profile, including blood gas levels, in Salmonella Dublin-infected calves

    Directory of Open Access Journals (Sweden)

    D.G. Silva

    2010-04-01

    Full Text Available O objetivo do estudo foi avaliar o hemograma e o perfil bioquímico sérico, inclusive hemogasométrico, de bezerros infectados experimentalmente com Salmonella Dublin. Foram utilizados 12 bezerros sadios da raça Holandesa com 10 a 15 dias de idade, distribuídos aleatoriamente em dois grupos experimentais: grupo-controle (n= 6 e grupo infectado com 10(8UFC de Salmonella Dublin (n=6. Os bezerros foram submetidos ao exame físico diário, e as amostras de sangue foram coletadas minutos antes da inoculação (0h e 24, 48, 72, 96, 120, 144 e 168h após a inoculação. Além do hemograma e das análises hemogasométricas, foram mensuradas as atividades séricas das enzimas aspartato aminotransferase (AST, fosfatase alcalina (ALP, creatina cinase (CK, gamaglutamiltransferase (GGT e lactato desidrogenase (LDH, e os teores de albumina, bilirrubinas, cálcio total, cálcio ionizado, sódio, potássio, cloretos, creatinina, ferro, fibrinogênio, fósforo, glicose, magnésio, proteína totais e ureia. As principais alterações foram: redução das concentrações de albumina, ferro, glicose, magnésio e proteína total, aumento do teor de fibrinogênio, leucocitose e acidose metabólica e hiponatremia.The blood cell counts and biochemical profile, including blood gas levels, were evaluated, in Salmonella Dublin-infected calves. Twelve healthy 10 to 15-day old Holstein calves were randomly allotted into two groups: control (n=6 and group orally infected with 10(8 CFU Salmonella Dublin (n=6. The calves were submitted to physical examination and the blood samples were taken just before the inoculation (0h and at 24, 48, 72, 96, 120, 144, and 168h later. Besides, blood cell counts, blood gas levels, and the serum concentrations of aspartate aminotransferase (AST, alkaline phosphatase (ALP, creatine kinase (CK, gammaglutamyltransferase (GGT, lactate desidrogenase (LDH, albumin, bilirubin, total calcium, ionic calcium, sodium, potassium, chlorides, creatinine

  2. Metabolomic Analysis of Clinical Plasma from Cerebral Infarction Patients Presenting with Blood Stasis

    Directory of Open Access Journals (Sweden)

    Min Ho Cha

    2015-01-01

    Full Text Available Blood stasis (BS is characterized as a disorder of blood circulation. In traditional Korean medicine (TKM, it is viewed as a cause factor of diseases such as multiple sclerosis and stroke. This study investigated differences in the plasma metabolites profiles of subjects displaying BS or non-BS patterns. Thirty-one patients with cerebral infarction diagnosed with BS and an equal number of sex- and age-matched non-BS patients were enrolled. Metabolic profiling was performed using UPLC-MS. The ratio of subjects with a rough pulse and purple coloration of the tongue was higher in patients presenting with BS pattern. Through metabolomics analysis, 82 metabolites that differed significantly between the BS and non-BS pattern were identified, and the two groups were significantly separated using an orthogonal partial least square-discriminant analysis model (P<0.001. Of these 82 metabolites, acetyl carnitine, leucine, kynurenine, phosphocholine, hexanoyl carnitine, and decanoyl carnitine were present in significantly higher levels in patients with a BS pattern than those with a non-BS pattern. Our results also demonstrated that seven plasma metabolites, including acyl-carnitines and kynurenine, were associated with a BS pattern, suggesting that variant plasma metabolic profiles may serve as a biomarker for diagnosis of BS in patients with cerebral infarction.

  3. Doppler sonography of diabetic feet: Quantitative analysis of blood flow volume

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Young Lan; Kim, Ho Chul; Choi, Chul Soon; Yoon, Dae Young; Han, Dae Hee; Moon, Jeung Hee; Bae, Sang Hoon [Hallym University College of Medicine, Seoul (Korea, Republic of)

    2002-09-15

    To analyze Doppler sonographic findings of diabetic feet by estimating the quantitative blood flow volume and by analyzing waveform on Doppler. Doppler sonography was performed in thirty four patients (10 diabetic patients with foot ulceration, 14 diabetic patients without ulceration and 10 normal patients as the normal control group) to measure the flow volume of the arteries of the lower extremities (posterior and anterior tibial arteries, and distal femoral artery. Analysis of doppler waveforms was also done to evaluate the nature of the changed blood flow volume of diabetic patients, and the waveforms were classified into triphasic, biphasic-1, biphasic-2 and monophasic patterns. Flow volume of arteries in diabetic patients with foot ulceration was increased witha statistical significance when compared to that of diabetes patients without foot ulceration of that of normal control group (P<0.05). Analysis of Doppler waveform revealed that the frequency of biphasic-2 pattern was significantly higher in diabetic patients than in normal control group(p<0.05). Doppler sonography in diabetic feet showed increased flow volume and biphasic Doppler waveform, and these findings suggest neuropathy rather than ischemic changes in diabetic feet.

  4. Parametric Analysis of a Two-Shaft Aeroderivate Gas Turbine of 11.86 MW

    OpenAIRE

    Lugo-Leyte, R.; Salazar-Pereyra, M.; H. D. Lugo Méndez; Aguilar-Adaya, I.; J. J. Ambriz-García; J. G. Vázquez Vargas

    2015-01-01

    The aeroderivate gas turbines are widely used for power generation in the oil and gas industry. In offshore marine platforms, the aeroderivative gas turbines provide the energy required to drive mechanically compressors, pumps and electric generators. Therefore, the study of the performance of aeroderivate gas turbines based on a parametric analysis is relevant to carry out a diagnostic of the engine, which can lead to operational as well as predictive and/or corrective maintenance actions. T...

  5. Economic impact analysis of natural gas development and the policy implications

    OpenAIRE

    De Silva, PNK; Simons, SJR; Stevens, P

    2016-01-01

    In the US, the shale gas revolution ensured that the development costs of unconventional natural gas plummeted to the levels of $2–3/Mcf. This success has motivated the development of shale gas in other regions, including Australia and Europe. This study, focussing primarily on aspects of economic impact analysis, estimates the development costs of shale gas extraction in both Australia and Europe, based on both direct and fiscal costs, and also suggests policy initiatives. The increasing liq...

  6. Discriminatory Analysis of Discharged Gas and Heavy Oils in the Sea

    OpenAIRE

    Masato Taki; Akira Yoshida; Kei Machigashira; Masaki Sakon; Masatoshi Nagai

    2011-01-01

    Gas and heavy oils discharged into the sea were discriminated using gas chromatography-mass spectrometry (GC-MS), gas chromatography (GC-FID) and infrared spectroscopy (FT-IR). The GC-MS focused on the determination of the biomarkers, such as hopanes, norhopanes and triaromatic steranes, which were detected from heavy oil, but were hardly observed from gas oil. The discriminative analysis using GC-FID of the methylnaphthalenes showed a discrimination with a ratio of ((2-methylnaphtha...

  7. Factor analysis of multigated cardiac blood pool scintigram for the measurement of left ventricular ejection fraction

    International Nuclear Information System (INIS)

    Left ventricular ejection fraction (EF) was measured by factor analysis (FA) of multigated cardiac blood pool scintigram in 38 consecutive patients, and compared with that measured by the variable ROI method (EFVROI) with automated left ventricular contour detection. FA was automatically performed without operator intervention with a success rate of 100%. The correlation of EF with EFVROI was significant in the group of 22 patients with normal wall motion (r=0.65, p<0.001), and the entire group of patients (r=0.70, p<0.001), but not significant (p=0.19) in the group of 16 patients with abnormal wall motion. In conclusion, left ventricular ejection fraction can be estimated by factor analysis of MUGA in patients with normal wall motion. (author)

  8. Concentration measurement of lysosome enzymes in blood by fluorimetric analysis method

    Science.gov (United States)

    Strinadko, Marina M.; Strinadko, Elena M.

    2002-02-01

    The diagnostics of heritable disease series and sugar diabetes, myocardial infarction, collagenosis and kidney diseases widely uses the measurement of lysosomic enzymes in blood. In the present research work the definition procedure of concentration (beta) -glucuronidase with the help of fluorimetric analysis is offered, which allows using microamounts of biological fluids and samples with low enzyme activity which is especially important in paediatric practice. Due to the sharp sensibility of fluorimetric analysis and high speed of luminescent reactions the procedure gives an opportunity to obtain the result in the minimum terms as well as the use of small amounts of reaction mixture. The incubation in large dilution leads thereby to the elimination of influence of endogenic inhibitors and activators.

  9. ABO Blood Group System and Gastric Cancer: A Case-Control Study and Meta-Analysis

    OpenAIRE

    Yingyan Yu; Zhenggang Zhu; Jun Zhang; Min Yan; Bingya Liu; Jianian Zhang; Jun Ji; Zhiwei Wang; Lei Liu

    2012-01-01

    This study focuses on the association between the ABO blood group system and the risk of gastric cancer or Helicobacter pylori infection. The data for the ABO blood group was collected from 1045 cases of gastric cancer, whereby the patient underwent a gastrectomy in Ruijin Hospital, Shanghai. The information on the ABO blood group from 53,026 healthy blood donors was enrolled as control. We searched the Pubmed database on the relationship between ABO blood groups and gastric cancer risk for m...

  10. Effects of xylazine on acid-base balance and arterial blood-gas tensions in goats under different environmental temperature and humidity conditions

    Directory of Open Access Journals (Sweden)

    E.G.M. Mogoa

    2000-07-01

    Full Text Available The effects of acute exposure to 3 different temperature and humidity conditions on arterial blood-gas and acid-base balance in goats were investigated after intravenous bolus administration of xylazine at a dose of 0.1 mg/kg. Significant (P < 0.05 changes in the variables occurred under all 3 environmental conditions. Decreases in pH, partial pressure of oxygen and oxyhaemoglobin saturation were observed, and the minimum values for oxygen tension and oxyhaemoglobin saturation were observed within 5 min of xylazine administration. The pH decreased to its minimum values between 5 and 15 min. Thereafter, the variables started to return towards baseline, but did not reach baseline values at the end of the 60 min observation period. Increases in the partial pressure of carbon dioxide, total carbon dioxide content, bicarbonate ion concentration, and the actual base excess were observed. The maximum increase in the carbon dioxide tension occurred within 5 min of xylazine administration. The increase in the actual base excess only became significant after 30 min in all 3 environments, and maximal increases were observed at 60 min. There were no significant differences between the variables in the 3 different environments. It was concluded that intravenous xylazine administration in goats resulted in significant changes in arterial blood-gas and acid-base balance that were associated with hypoxaemia and respiratory acidosis, followed by metabolic alkalosis that continued for the duration of the observation period. Acute exposure to different environmental temperature and humidity conditions after xylazine administration did not influence the changes in arterial blood-gas and acid-base balance.

  11. Flammable gas tank safety program: Technical basis for gas analysis and monitoring

    International Nuclear Information System (INIS)

    Flammable gases generated in radioactive liquids. Twenty-five high level radioactive liquid waste storage tanks located underground at the Hanford Site are on a Flammable Gas Watch List because they contain waste which tends to retain the gases generated in it until rather large quantities are available for sudden release to the tank head space; if a tank is full it has little dome space, and a flammable concentration of gases could be produced--even if the tank is ventilated. If the waste has no tendency to retain gas generated in it then a continual flammable gas concentration in the tank dome space is established by the gas production rate and the tank ventilation rate (or breathing rate for unventilated tanks); this is also a potential problem for Flammable Gas Watch List tanks, and perhaps other Hanford tanks too. All Flammable Gas Watch List tanks will be fitted with Standard Hydorgen Monitoring Systems so that their behavior can be observed. In some cases, such as tank 241-SY-101, the data gathered from such observations will indicate that tank conditions need to be mitigated so that gas release events are either eliminated or rendered harmless. For example, a mixer pump was installed in tank 241-SY-101; operating the pump stirs the waste, replacing the large gas release events with small releases of gas that are kept below twenty-five percent of the lower flammability limit by the ventilation system. The concentration of hydrogen measured in Hanford waste tanks is greater than that of any other flammable gas. Hydrogen levels measured with a Standard Hydrogen Monitoring System in excess of 0.6 volume percent will cause Westinghouse Hanford Company to consider actions which will decrease the amount of flammable gas in the tank

  12. A versatile gas interface for routine radiocarbon analysis with a gas ion source

    International Nuclear Information System (INIS)

    In 2010 more than 600 radiocarbon samples were measured with the gas ion source at the MIni CArbon DAting System (MICADAS) at ETH Zurich and the number of measurements is rising quickly. While most samples contain less than 50 μg C at present, the gas ion source is attractive as well for larger samples because the time-consuming graphitization is omitted. Additionally, modern samples are now measured down to 5 per-mill counting statistics in less than 30 min with the recently improved gas ion source. In the versatile gas handling system, a stepping-motor-driven syringe presses a mixture of helium and sample CO2 into the gas ion source, allowing continuous and stable measurements of different kinds of samples. CO2 can be provided in four different ways to the versatile gas interface. As a primary method, CO2 is delivered in glass or quartz ampoules. In this case, the CO2 is released in an automated ampoule cracker with 8 positions for individual samples. Secondly, OX-1 and blank gas in helium can be provided to the syringe by directly connecting gas bottles to the gas interface at the stage of the cracker. Thirdly, solid samples can be combusted in an elemental analyzer or in a thermo-optical OC/EC aerosol analyzer where the produced CO2 is transferred to the syringe via a zeolite trap for gas concentration. As a fourth method, CO2 is released from carbonates with phosphoric acid in septum-sealed vials and loaded onto the same trap used for the elemental analyzer. All four methods allow complete automation of the measurement, even though minor user input is presently still required. Details on the setup, versatility and applications of the gas handling system are given.

  13. Gas exchange and the coagulation system of the blood during the effect on the body of high concentrations of oxygen and carbon dioxide

    Science.gov (United States)

    Palosh, L.; Agadzhanyan, N. A.; Davydov, G. A.; Rybakov, B. K.; Sergiyenko, A. S.

    1974-01-01

    Maximum permissible concentrations of oxygen and carbon dioxide in a controlled atmosphere were determined by evaluating their effects on human gas exchange, blood coagulation, and tolerances to acute hypoxia, acceleration, and physical loads. It was found that functional disturbances depend on the concentration of respiratory gases and the length of stay in an altered atmosphere. By changing the atmospheric composition and by bringing the gaseous environment into accordance with the work and rest regimen and energy expenditures, the general reactivity of the body changes favorably.

  14. Effect of substitution of corn for molasses in diet on growth performance, nutrient digestibility, blood characteristics, fecal noxious gas emission, and meat quality in finishing pigs

    OpenAIRE

    Shanmugam Sureshkumar; Sang In Lee; Doo Seok Nam; In Ho Kim

    2016-01-01

    ABSTRACT The objective of this experiment was to evaluate the effect of molasses as a substitute for corn in diet on growth performance, nutrient digestibility, blood characteristics, fecal noxious gas emission, and meat quality in finishing pigs. A total of 120 [(Landrace × Yorkshire) × Duroc] pigs with an average initial body weight (BW) of 54.21±2.62 kg were used in this experiment. Pigs were randomly assigned to 1 of the 3 dietary treatments on the basis of BW and sex (10 replicate pens p...

  15. Effect of Fermented Chlorella Supplementation on Growth Performance, Nutrient Digestibility, Blood Characteristics, Fecal Microbial and Fecal Noxious Gas Content in Growing Pigs

    OpenAIRE

    Yan, L.; Lim, S. U.; Kim, I. H.

    2012-01-01

    A total of 96 growing pigs ((Landrace×Yorkshire)×Duroc; BW = 26.58±1.41 kg) were used in a 6-wk feeding trail to evaluate the effects of fermented chlorella (FC) supplementation on growth performance, nutrient digestibility, blood characteristics, fecal microbial and fecal noxious gas content in growing pigs. Pigs were randomly allotted into 1 of 4 dietary treatments with 6 replicate pens (2 barrows and 2 gilts) per treatment. Dietary treatments were: i) negative control (NC), basal diet (wit...

  16. Analysis on hidden blood loss of total knee arthroplasty in treating knee osteoarthritis

    Institute of Scientific and Technical Information of China (English)

    SHEN Hui-liang; LI Zheng; FENG Ming-li; CAO Guang-le

    2011-01-01

    Background Total knee arthroplasty (TKA) is an important therapy for the treatment of various late-stage knee diseases. However, it has been observed that patients have lower hemoglobin (HB) counts postoperatively, which are significantly inconsistent with the measured blood loss. Although the concept of hidden blood loss has been presented in 2000, very little clinical attention has been paid since then. In this study, we investigated the characteristics and influential factor of hidden blood loss after TKA in treating knee osteoarthritis.Methods One hundred and eight patients, with 42 males and 66 females, were retrospectively analyzed. The perioperative blood loss and the hidden blood loss following TKA were calculated by Gross formula. Potential factors affecting perioperative and hidden blood loss included gender, surgical time, tourniquet time, hemostasis (during operation with deflating tourniquet), and reinfusion of salvaged blood.Results The average perioperative blood loss was found to be (1553±356) ml and the average hidden blood loss was (793±223) ml. The hidden blood loss of the male was significantly higher than that of the female, and was reduced by hemostasis during the operation with a deflating tourniquet. Hidden blood loss was not affected by postoperative blood salvage and reinfusion, surgical time, or tourniquet time.Conclusions When calculating the value of hidden blood loss by Gross formula, the lowest value of hematocrit should be chosen as the parameter so that hidden blood loss would not be underestimated. No significant differences could be found in hidden blood loss for males compared to females. Hidden blood loss can be reduced by hemostasis during operation with a deflating tourniquet. Although reinfusion of salvaged blood could not reduce the perioperative blood loss or hidden blood loss, it was still an effective method to reduce transfusion rate.

  17. Analysis of a sustainable gas cooled fast breeder reactor concept

    International Nuclear Information System (INIS)

    Highlights: • A Thorium-GFBR breeder for actinide recycling ability, and thorium fuel feasibility. • A mixture of 232Th and 233U is used as fuel and LWR used fuel is used. • Detailed neutronics, fuel cycle, and thermal-hydraulics analysis has been presented. • Run this TGFBR for 20 years with breeding of 239Pu and 233U. • Neutronics analysis using MCNP and Brayton cycle for energy conversion are used. - Abstract: Analysis of a thorium fuelled gas cooled fast breeder reactor (TGFBR) concept has been done to demonstrate the self-sustainability, breeding capability, actinide recycling ability, and thorium fuel feasibility. Simultaneous use of 232Th and used fuel from light water reactor in the core has been considered. Results obtained confirm the core neutron spectrum dominates in an intermediate energy range (peak at 100 keV) similar to that seen in a fast breeder reactor. The conceptual design achieves a breeding ratio of 1.034 and an average fuel burnup of 74.5 (GWd)/(MTHM) . TGFBR concept is to address the eventual shortage of 235U and nuclear waste management issues. A mixture of thorium and uranium (232Th + 233U) is used as fuel and light water reactor used fuel is utilized as blanket, for the breeding of 239Pu. Initial feed of 233U has to be obtained from thorium based reactors; even though there are no thorium breeders to breed 233U a theoretical evaluation has been used to derive the data for the source of 233U. Reactor calculations have been performed with Monte Carlo radiation transport code, MCNP/MCNPX. It is determined that this reactor has to be fuelled once every 5 years assuming the design thermal power output as 445 MW. Detailed analysis of control rod worth has been performed and different reactivity coefficients have been evaluated as part of the safety analysis. The TGFBR concept demonstrates the sustainability of thorium, viability of 233U as an alternate to 235U and an alternate use for light water reactor used fuel as a blanket for

  18. Dynamic Modeling and Analysis of an Industrial Gas Suspension Absorber for Flue Gas Desulfurization

    DEFF Research Database (Denmark)

    Cignitti, Stefano; Mansouri, Seyed Soheil; Sales-Cruz, Mauricio;

    2016-01-01

    In this work, semidry desulfurization of flue gas using a gas suspension absorber (GSA) is studied. A simple dynamic model which can properly represent the GSA was developed. In order to model the reaction kinetics, an empirical reaction rate expression was introduced. The reaction rate expressio...

  19. Pulsatile microvascular blood flow imaging by short-time Fourier transform analysis of ultrafast laser holographic interferometry

    CERN Document Server

    Puyo, L; Rancillac, A; Simonutti, M; Paques, M; Sahel, J A; Fink, M; Atlan, M

    2015-01-01

    We report on wide-field imaging of pulsatile microvascular blood flow in the exposed cerebral cortex of a mouse by holographic interferometry. We recorded interferograms of laser light backscattered by the tissue, beating against an off-axis reference beam with a 50 kHz framerate camera. Videos of local Doppler contrasts were rendered numerically by Fresnel transformation and short-time Fourier transform analysis. This approach enabled instantaneous imaging of pulsatile blood flow contrasts in superficial blood vessels over 256 x 256 pixels with a spatial resolution of 10 microns and a temporal resolution of 20 ms.

  20. Blood Clots

    Science.gov (United States)

    ... Index A-Z Blood Clots Blood clots are semi-solid masses of blood that can be stationary (thrombosis) ... treated? What are blood clots? Blood clots are semi-solid masses of blood. Normally, blood flows freely through ...

  1. An Econometric Analysis of the Market for Natural Gas Futures

    OpenAIRE

    W. David Walls

    1995-01-01

    This research tests a form of the efficient markets hypothesis in the, market for natural gas futures. Unlike other studies of futures markets, the test for market efficiency is conducted at numerous locations which comprise the, natural gas spot market in addition to the delivery location specified in the futures contract. Natural gas spot and futures prices are found to be nonstationary and accordingly are modeled using recently developed maximum likelihood cointegration techniques. The fut...

  2. Patterns of self-monitoring of blood glucose in insulin-treated diabetes: analysis of a Scottish population over time.

    Science.gov (United States)

    Cameron, D; Harris, F M; Evans, J M M

    2016-07-01

    Analysis of a diabetes clinical information system in Tayside, Scotland, shows that a significant proportion of insulin-treated patients with diabetes are not self-monitoring blood glucose according to current clinical guidance and recommendations, with some not self-monitoring their blood glucose at all. Although there has been an increase in the number of reagent strips dispensed over the past decade, this increase is mainly accounted for by increased testing frequency among people with diabetes already testing. PMID:26990502

  3. Size at birth, maternal nutritional status in pregnancy, and blood pressure at age 17: population based analysis.

    OpenAIRE

    Laor, A.; Stevenson, D K; Shemer, J; Gale, R; Seidman, D S

    1997-01-01

    OBJECTIVE: To assess the effect of size at birth, maternal nutrition, and body mass index on blood pressure in late adolescence. DESIGN: Population based analysis of birth weight corrected for gestational age, mother's weight before pregnancy and weight gain in pregnancy, obtained from the Jerusalem perinatal study, and blood pressure and body mass index at age 17, available from military draft records. SETTING: Jerusalem, Israel. SUBJECTS: 10,883 subjects (6684 men and 4199 women) born in Je...

  4. Correlation dimension estimate and its potential use in analysis of gas-solid flows

    DEFF Research Database (Denmark)

    Yin, Chungen; Rosendahl, Lasse Aistrup; Kær, Søren Knudsen

    2005-01-01

    Gas-solid flows are nonlinear systems. Therefore state-space analysis, a tool developed within the framework of nonlinear dynamics, could provide more useful insights into complex gas-solid flows. One of the positive aspects of state-space analysis is that the major properties of a system can be ...

  5. Economics of lifecycle analysis and greenhouse gas regulations

    Science.gov (United States)

    Rajagopal, Deepak

    2009-11-01

    Interest in alternatives to fossil fuels has risen significantly during the current decade. Although a variety of different alternative technologies have experienced rapid growth, biofuels have emerged as the main alternative transportation fuel. Energy policies in several countries envision blending biofuels with fossil fuels as the main mechanism to increase energy independence and energy security. Climate change policies in several regions are also riding on the same hope for reducing emissions from transportation. The main advantage of biofuels is that they are technically mature, cheaper to produce and more convenient to use relative to other alternative fuels. However, the impact of current biofuels on the environment and on economic welfare, is controversial. In my dissertation I focus on three topics relevant to future energy and climate policies. The first is the economics of lifecycle analysis and its application to the assessment of environmental impact of biofuel policies. The potential of biofuel for reducing greenhouse gas emissions was brought to the fore by research that relied on the methodology called lifecycle analysis (LCA). Subsequent research however showed that the traditional LCA fails to account for market-mediated effects that will arise when biofuel technologies are scaled up. These effects can increase or decrease emissions at each stage of the lifecycle. I discuss how the LCA will differ depending on the scale, a single firm versus a region and why LCA of the future should be distinguished from LCA of the past. I describe some approaches for extending the LCA methodology so that it can be applied under these different situations. The second topic is the economic impact of biofuels. Biofuels reduce the demand for oil and increase the demand for agricultural goods. To high income countries which tend to be both large importers of oil and large exporters of agricultural goods, this implies two major benefits. One of the one hand it reduces

  6. [Comparative transcriptome analysis of human aorta atherosclerotic lesions and peripheral blood leukocytes from essential hypertension patients].

    Science.gov (United States)

    Timofeeva, A V; Goriunova, L E; Khaspekov, G L; Il'inskaia, O P; Sirotkin, V N; Andreeva, E R; Tararak, E M; Bulkina, O S; Buza, V V; Britareva, V V; Karpov, Iu A; Bibilashvili, R Sh

    2009-01-01

    One of the major cardiovascular risk factor which predisposes to and accelerates atherosclerosis is arterial hypertension (AH). To determine the molecular basis of the crosslink between AH and atherosclerosis for the development of new treatment strategies large-scale transcriptome analysis of the cells implicated in atherogenesis is needed. We used cDNA microarray technique for simultaneous analysis of gene expression in human abdominal aorta normal sites and atherosclerotic lesions of different histological types, as well as in peripheral blood leukocytes from patients with essential hypertension (EH) and donors. The microarray data were verified by quantitative RT-PCR (reverse transcription coupled with polymerase chain reaction) and immunohistochemical analysis. Differential expression of 40 genes has been found, among which twenty two genes demonstrated up-regulation and 18 genes demonstrated down-regulation in atherosclerotic aorta compared with normal vessel. New gene-candidates, implicated in atherogenesis, have been identified - FPRL2, CD37, CD53, RGS1, LCP1, SPI1, CTSA, EPAS1, FHL1, GEM, RHOB, SPARCL1, ITGA8, PLN, and COL14A1. These genes participate in cell migration and adhesion, phenotypic changes of smooth muscle cells, immune and inflammatory reactions, oxidative processes and extracellular matrix remodeling. We have found increased expression levels of CD53, SPI1, FPRL2, SPP1, CTSD, ACP5, LCP1, CTSA and LIPA genes in peripheral blood leukocytes from EH patients and in atherosclerotic lesions of human aorta. The majority of these genes significantly (p0.5) correlated with AH stage as well as with histological grading of atherosclerotic lesions. PMID:19772500

  7. Analysis of carbon dioxide emission of gas fuelled cogeneration plant

    International Nuclear Information System (INIS)

    Gas turbines are widely used for power generation. In cogeneration system, the gas turbine generates electricity and the exhaust heat from the gas turbine is used to generate steam or chilled water. Besides enhancing the efficiency of the system, the process assists in reducing the emission of CO2 to the environment. This study analyzes the amount of CO2 emission by Universiti Teknologi Petronas gas fuelled cogeneration system using energy balance equations. The results indicate that the cogeneration system reduces the CO2 emission to the environment by 60%. This finding could encourage the power plant owners to install heat recovery systems to their respective plants

  8. Analysis of carbon dioxide emission of gas fuelled cogeneration plant

    Science.gov (United States)

    Nordin, Adzuieen; Amin, M.; Majid, A.

    2013-12-01

    Gas turbines are widely used for power generation. In cogeneration system, the gas turbine generates electricity and the exhaust heat from the gas turbine is used to generate steam or chilled water. Besides enhancing the efficiency of the system, the process assists in reducing the emission of CO2 to the environment. This study analyzes the amount of CO2 emission by Universiti Teknologi Petronas gas fuelled cogeneration system using energy balance equations. The results indicate that the cogeneration system reduces the CO2 emission to the environment by 60%. This finding could encourage the power plant owners to install heat recovery systems to their respective plants.

  9. Genetic Analysis of ABO and Rh Blood Groups in Backward Caste Population of Uttar Pradesh, India

    OpenAIRE

    Rai, Vandana; Kumar, Pradeep

    2011-01-01

    A series of glycoproteins and glycolipids on red blood cell surface constitute blood group antigens. These are AB, A, B and O in ABO blood group system and Rh in rhesus blood group system. A total of 1065 unrelated Backward Caste (OBC) individuals from Uttar Pradesh were studied for the phenotype and allele frequency distribution of ABO and Rh (D) blood groups. Total 1065 samples analyzed, phenotype B blood type has the highest frequency 36.81% (n=392), followed by O (32.68%; n=348), A (23.66...

  10. Unsteady thermal analysis of gas-cooled fast reactor core

    International Nuclear Information System (INIS)

    This thesis presents numerical analysis of transient heat transfer in an equivalent coolant-fuel rod cell of a typical gas cooled, fast nuclear reactor core. The transient performance is assumed to follow a complete sudden loss of coolant starting from steady state operation. Steady state conditions are obtained from solving a conduction problem in the fuel rod and a parabolic turbutent convection problem in the coolant section. The coupling between the two problems is accomplished by ensuring continuity of the thermal conditions at the interface between the fuel rod and the coolant. to model turbulence, the mixing tenght theory is used. Various fuel rod configurations have been tested for optimal transient performance. Actually, the loss of coolant accident occurs gradually at an exponential rate. Moreover, a time delay before shutting down the reactor by insertion of control rods usually exists. It is required to minimize maximum steady state cladding temperature so that the time required to reach its limiting value during transient state is maximum. This will prevent the escape of radioactive gases that endanger the environment and the public. However, the case considered here is a limiting case representing what could actually happen in the worst probable accident. So, the resutls in this thesis are very indicative regarding selection of the fuel rode configuration for better transient performance in case of accidents in which complete loss of collant occurs instantaneously

  11. Multiphysics methods development for high temperature gas reactor analysis

    Science.gov (United States)

    Seker, Volkan

    Multiphysics computational methods were developed to perform design and safety analysis of the next generation Pebble Bed High Temperature Gas Cooled Reactors. A suite of code modules was developed to solve the coupled thermal-hydraulics and neutronics field equations. The thermal-hydraulics module is based on the three dimensional solution of the mass, momentum and energy equations in cylindrical coordinates within the framework of the porous media method. The neutronics module is a part of the PARCS (Purdue Advanced Reactor Core Simulator) code and provides a fine mesh finite difference solution of the neutron diffusion equation in three dimensional cylindrical coordinates. Coupling of the two modules was performed by mapping the solution variables from one module to the other. Mapping is performed automatically in the code system by the use of a common material mesh in both modules. The standalone validation of the thermal-hydraulics module was performed with several cases of the SANA experiment and the standalone thermal-hydraulics exercise of the PBMR-400 benchmark problem. The standalone neutronics module was validated by performing the relevant exercises of the PBMR-268 and PBMR-400 benchmark problems. Additionally, the validation of the coupled code system was performed by analyzing several steady state and transient cases of the OECD/NEA PBMR-400 benchmark problem.

  12. Applications of laser-photoacoustic gas analysis method

    Energy Technology Data Exchange (ETDEWEB)

    Hernberg, R.; Stenberg, J. [Tampere Univ. of Technology (Finland). Dept. of Physics

    1996-12-01

    The dynamic behavior of a circulating fluidized bed boiler (CFB) was studied using two high speed gas analysis systems during combustion of coal, peat and wood chips. Time resolved concentrations of some pollutants (SO{sub 2}, NO, NH{sub 3} and H{sub 2}S) were measured using laser induced photoacoustic spectroscopy (LIPS). A zirkonia cell based probe (lambda-probe) was used in synchronization with the LIPS-probe to measure fluctuations between reducing and oxidizing conditions. The two probes were positioned in the same measurement volume on the center-line of the combustion chamber of the CFB. The purpose of the measurements was to investigate the behavior of the LIPS in a combustion chamber containing large amounts of other unburnt hydrocarbons. The correlations between oxidizing and reducing conditions and concentrations at three locations in the combustion chamber are presented. The best correlations were found in the upper part of the CFB combustion chamber. In some cases the correlations between reducing conditions and the LIPS signal were caused by hydrocarbons. Comparison of the average values obtained by the LIPS-system for NO and SO{sub 2} with the result from a sampling probe system connected to on-line analysers was also carried out. (author)

  13. Application of parabolic reflector on Raman analysis of gas samples

    Science.gov (United States)

    Yu, Anlan; Zuo, Duluo; Gao, Jun; Li, Bin; Wang, Xingbing

    2016-05-01

    Studies on the application of a parabolic reflector in spontaneous Raman scattering for low background Raman analysis of gas samples are reported. As an effective signal enhancing sample cell, photonic bandgap fiber (HC-PBF) or metallined capillary normally result in a strong continuous background in spectra caused by the strong Raman/fluorescence signal from the silica wall and the polymer protective film. In order to obtain enhanced signal with low background, a specially designed sample cell with double-pass and large collecting solid angle constructed by a parabolic reflector and a planar reflector was applied, of which the optical surfaces had been processed by diamond turning and coated by silver film and protective film of high-purity alumina. The influences of optical structure, polarization characteristic, collecting solid-angle and collecting efficiency of the sample cell on light propagation and signal enhancement were studied. A Raman spectrum of ambient air with signal to background ratio of 94 was acquired with an exposure time of 1 sec by an imaging spectrograph. Besides, the 3σ limits of detection (LOD) of 7 ppm for H2, 8 ppm for CO2 and 12 ppm for CO were also obtained. The sample cell mainly based on parabolic reflector will be helpful for compact and high-sensitive Raman system.

  14. Venus lower atmospheric composition: analysis by gas chromatography.

    Science.gov (United States)

    Oyama, V I; Carle, G C; Woeller, F; Pollack, J B

    1979-02-23

    The first gas chromatographic analysis of the lower atmosphere of Venus is reported. Three atmospheric samples were analyzed. The third of these samples showed carbon dioxide (96.4 percent), molecular nitrogen (3.41 percent), water vapor (0.135 percent), molecular oxygen [69.3 parts per million (ppm)], argon (18.6 ppm), neon (4.31 ppm), and sulfuir dioxide (186 ppm). The amounts of water vapor and sulfur dioxide detected are roughly compatible with the requirements of greenhouse models of the high surface temperature of Venus. The large positive gradient of sulfur dioxide, molecular oxygen, and water vapor from the clould tops to their bottoms, as implied by Earth-based observations and these resuilts, gives added support for the presence of major quantities of aqueous sulfuric acid in the clouds. A comparison of the inventory of inert gases found in the atmospheres of Venus, Earth, and Mars suggests that these components are due to outgassing from the planetary interiors. PMID:17833004

  15. Involvement of placental/umbilical cord blood acid-base status and gas values on the radiosensitivity of human fetal/neonatal hematopoietic stem/progenitor cells

    International Nuclear Information System (INIS)

    Arterial cord blood (CB) acid-base status and gas values, such as pH, PCO2, PO2, HCO3- and base excess, provide useful information on the fetal and neonatal condition. However, it remains unknown whether these values affect the radiosensitivity of fetal/neonatal hematopoiesis. The present study evaluated the relationship between arterial CB acid-base status, gas values, and the radiosensitivity of CB hematopoietic stem/progenitor cells (HSPCs). A total of 25 CB units were collected. The arterial CB acid-base status and gas values were measured within 30 min of delivery. The CD34+ HSPCs obtained from CB were exposed to 2 Gy X-irradiation, and then assayed for colony-forming unit-granulocyte-macrophage, burst-forming unit-erythroid (BFU-E), and colony-forming unit-granulocyte erythroid, macrophage and megakaryocyte cells. Acid-base status and gas values for PCO2 and HCO3- showed a statistically significant negative correlation with the surviving fraction of BFU-E. In addition, a significant positive correlation was observed between gestational age and PCO2. Moreover, the surviving fraction of BFU-E showed a significant negative correlation with gestational age. Thus, HSPCs obtained from CB with high PCO2/HCO3- levels were sensitive to X-irradiation, which suggests that the status of arterial PCO2/HCO3- influences the radiosensitivity of fetal/neonatal hematopoiesis, especially erythropoiesis. (author)

  16. Diagnostic prediction of renal failure from blood serum analysis by FTIR spectrometry and chemometrics

    Science.gov (United States)

    Khanmohammadi, Mohammdreza; Ghasemi, Keyvan; Garmarudi, Amir Bagheri; Ramin, Mehdi

    2015-02-01

    A new diagnostic approach based on Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) spectrometry and classification algorithm has been introduced which provides a rapid, reliable, and easy way to perform blood test for the diagnosis of renal failure. Blood serum samples from 35 renal failure patients and 40 healthy persons were analyzed by ATR-FTIR spectrometry. The resulting data was processed by Quadratic Discriminant Analysis (QDA) and QDA combined with simple filtered method. Spectroscopic studies were performed in 900-2000 cm-1 spectral region with 3.85 cm-1 data space. Results showed 93.33% and 100% of accuracy for QDA and filter-QDA models, respectively. In the first step, 30 samples were applied to construct the model. In order to modify the capability of QDA in prediction of test samples, filter-based feature selection methods were applied. It was found that the filtered spectra coupled with QDA could correctly predict the test samples in most of the cases.

  17. Microfluidic structures for flow cytometric analysis of hydrodynamically focussed blood cells fabricated by ultraprecision micromachining.

    Science.gov (United States)

    Kummrow, A; Theisen, J; Frankowski, M; Tuchscheerer, A; Yildirim, H; Brattke, K; Schmidt, M; Neukammer, J

    2009-04-01

    We present three-dimensional microfluidic structures with integrated optical fibers, mirrors and electrodes for flow cytometric analysis of blood cells. Ultraprecision milling technique was used to fabricate different flow cells featuring single-stage and two-stage cascaded hydrodynamic focusing of particles by a sheath flow. Two dimensional focussing of the sample fluid was proven by fluorescence imaging in horizontal and vertical directions and found to agree satisfactorily with finite element calculations. Focussing of the sample stream down to 5 microm at a particle velocity of 3 m s(-1) is accessible while maintaining stable operation for sample flow rates of up to 20 microL min(-1). In addition to fluorescence imaging, the micro-flow cells were characterised by measurements of pulse shapes and pulse height distributions of monodisperse microspheres. We demonstrated practical use of the microstructures for cell differentiation employing light scatter to distinguish platelets and red blood cells. Furthermore, T-helper lymphocytes labelled by monoclonal antibodies were identified by measuring side scatter and fluorescence. PMID:19294310

  18. Modeling and analysis of ultrasound backscattering by spherical aggregates and rouleaux of red blood cells.

    Science.gov (United States)

    Teh, B G; Cloutier, G

    2000-01-01

    The present study concerns the modeling and analysis of ultrasound backscattering by red blood cell (RBC) aggregates, which under pathological conditions play a significant role in the rheology of blood within human vessels. A theoretical model based on the convolution between a tissue matrix and a point spread function, representing, respectively, the RBC aggregates and the characteristics of the ultrasound system, was used to examine the influence of the scatterer shape and size on the backscattered power. Both scatterers in the form of clumps of RBC aggregates and rouleaux were modeled. For all simulations, the hematocrit was kept constant at 10%, the ultrasound frequency was 10 MHz, the insonification angle was varied from 0 to 90 degrees , and the scatterer size (diameter for clumps and length for rouleaux) ranged from 4 mum to 120 mum. Under Rayleigh scattering by assuming a Poisson distribution of scatterers in space, the ultrasound backscattered power increased linearly with the particle volume. For non-Rayleigh scatterers, the intensity of the echoes diminished as the scatterer volume increased, with the exception of rouleaux at an angle of 90 degrees . As expected, the backscattered power was angularly dependent for anisotropic particles (rouleaux). The ultrasound backscattered power did not always increase with the size of the aggregates, especially when they were no longer Rayleigh scatterers. In the case of rouleaux, the anisotropy of the backscattered power is emphasized in the non-Rayleigh region. PMID:18238637

  19. Engineering Economic Analysis for Feed Gas Cooler (Cold box: a Case of a Gas Processing Complex in Malaysia

    Directory of Open Access Journals (Sweden)

    Ghazali Zulkipli

    2014-07-01

    Full Text Available This study examine the economic feasibility of a proposal to replace an existing Feed Gas Cooler (Cold Box with a new unit in a gas processing complex in Malaysia. Economic justification is essential to make the decision on the feasibility of this undertaking because of the high capital investment. The mathematical model presented in the paper includes net present worth, payback period, rate of return, investment balance analysis, and sensitivity analysis. Critical analyses on four factors of the estimates were done to assess their influence on the overall economic justification of the proposal. The results indicate an acceptable return on investment. However, the proposal is susceptible to the variation in demand of the Feed Gas Load.

  20. Simple gas chromatographic system for analysis of microbial respiratory gases

    Science.gov (United States)

    Carle, G. C.

    1972-01-01

    Dual column ambient temperature system, consisting of pair of capillary columns, microbead thermistor detector and micro gas-sampling valve, is used in remote life-detection equipment for space experiments. Performance outweighs advantage gained by utilizing single-column systems to reduce weight, conserve carrier gas and operate at lower power levels.

  1. On-line non-contact gas analysis

    DEFF Research Database (Denmark)

    Fateev, Alexander; Clausen, Sønnik

    Non-intrusive and fast measurements of the gas temperature, NO and other gas concentrations at elevated temperatures in boilers, engines and flames are of the great interest. The optical properties of the gases must be known in a spectral range and temperature level of interest. High-resolution IR...

  2. Modeling prosthetic heart valves for numerical analysis of blood flow in the heart

    International Nuclear Information System (INIS)

    This paper extends our previous work on numerical analysis of blood flow in the heart. In that work the boundary forces were evaluated by solving a fixed-point problem, which we now reformulate as a problem in optimization. This optimization problem, which involves the energy function from which the boundary forces are derived, is solved by Murray's modification of Newton's method. The energy function turns out to be an extremely useful tool in modeling prosthetic heart valves. To enforce a constraint on the valve, we use an energy function which is zero when the constraint is satisfied and positive other wise. The energy function must be invariant under translation and rotation so that convervation of momentum and angular momentum will be satisfied. We use this technique to construct computer models of several prosthetic valves, and we study the flow patterns of these valves in our computer test chamber

  3. Microfluidic amperometric sensor for analysis of nitric oxide in whole blood.

    Science.gov (United States)

    Hunter, Rebecca A; Privett, Benjamin J; Henley, W Hampton; Breed, Elise R; Liang, Zhe; Mittal, Rohit; Yoseph, Benyam P; McDunn, Jonathan E; Burd, Eileen M; Coopersmith, Craig M; Ramsey, J Michael; Schoenfisch, Mark H

    2013-06-18

    Standard photolithographic techniques and a nitric oxide (NO) selective xerogel polymer were utilized to fabricate an amperometric NO microfluidic sensor with low background noise and the ability to analyze NO levels in small sample volumes (~250 μL). The sensor exhibited excellent analytical performance in phosphate buffered saline, including a NO sensitivity of 1.4 pA nM(-1), a limit of detection (LOD) of 840 pM, and selectivity over nitrite, ascorbic acid, acetaminophen, uric acid, hydrogen sulfide, ammonium, ammonia, and both protonated and deprotonated peroxynitrite (selectivity coefficients of -5.3, -4.2, -4.0, -5.0, -6.0, -5.8, -3.8, -1.5, and -4.0, respectively). To demonstrate the utility of the microfluidic NO sensor for biomedical analysis, the device was used to monitor changes in blood NO levels during the onset of sepsis in a murine pneumonia model. PMID:23692300

  4. Analysis of Chinese Accounting Standards for the Oil and Gas Industry and Related Enterprises

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Accounting standards are the tools for distribution of the revenues. Their development trend is influenced by their stakeholders. The evolution of American oil and gas accounting standards has been shaped by the profit-maximizing process of American oil and gas company shareholders, which for outside lobbying relied on their huge capital and organization. The development and perfection of Chinese new oil and gas accounting standards should consider not only the criterion of standards but also the real political fact in China oil and gas industry. The research on oil and gas accounting standards is an academic study as well as a political analysis.

  5. Cost-effective and Rapid Blood Analysis on a Cell-phone

    OpenAIRE

    Zhu, Hongying; Sencan, Ikbal; Wong, Justin; Dimitrov, Stoyan; Tseng, Derek; Nagashima, Keita; Ozcan, Aydogan

    2013-01-01

    We demonstrate a compact and cost-effective imaging cytometry platform installed on a cell-phone for the measurement of the density of red and white blood cells as well as hemoglobin concentration in human blood samples. Fluorescent and bright-field images of blood samples are captured using separate optical attachments to the cell-phone and are rapidly processed through a custom-developed smart application running on the phone for counting of blood cells and determining hemoglobin density. W...

  6. Analysis of a gas absorption system with soluble carrier gas and volatile solvent

    International Nuclear Information System (INIS)

    The effects of column diameter, carrier gas coabsorption, and solvent vaporization on the performance of a packed gas absorption column are examined. The system investigated employs dichlorodifluoromethane as a solvent to remove krypton from a nitrogen stream and is characterized by substantial nitrogen coabsorption. Three columns with diameters of 2, 3, and 4 inches were constructed and packed with 34.5 inches of Goodloe packing. In addition to the more conventional data, the experimental evaluation of these columns included the use of a radioisotope and a gamma scanning technique which provided direct measurement of the columns' molar krypton profiles. A multicomponent gas absorption model was developed, based on the two-film mass transfer theory, that allows the fluxes of all species to interact. Verification of this model was achieved through comparison of the calculated results with experimental data. With the feed gas flow rate between 6 and 36 lb moles/hr-ft2 and the solvent feed rate between 40 and 400 lb moles/hr-ft2, column diameter was found to have no significant impact on the mass transfer efficiency of this system when carried out in columns with diameters of 2 inches or greater. The absorption of krypton was found to be enhanced and inhibited, respectively, by carrier gas coabsorption and solvent vaporization. An injector system to add gaseous solvent to the feed gas stream prior to its introduction into the packed bed was proposed to eliminate the detrimental effects of solvent vaporization.Using this injector to supersaturate the feed gas stream with solvent enhanced absorber performance in the same manner as carrier gas coabsorption

  7. Structural analysis of the RH-like blood group gene products in nonhuman primates

    Energy Technology Data Exchange (ETDEWEB)

    Salvignol, I. [Centre Regional de Transfusion Sanguine, Toulouse (France); Calvas, P.; Blancher, A. [Universitaire d`Immunogenetique moleculaire, Toulouse (France); Socha, W.W. [University Medical Center, New York, NY (United States); Colin, Y.; Le Van Kim, C.; Bailly, P.; Cartron, J.P. [Institut National de la Transfusion Sanguine, Paris (France); Ruffie, J.; Blancher, A. [College de France, Paris (France)

    1995-03-01

    Rh-related transcripts present in bone marrow samples from several species of nonhuman primates (chimpanzee, gorilla, gibbon, crab-eating macaque) have been amplified by RT-polymerase chain reaction using primers deduced from the sequence of human RH genes. Nucleotide sequence analysis of the nonhuman transcripts revealed a high degree of similarity to human blood group Rh sequences, suggesting a great conservation of the RH genes throughout evolution. Full-length transcripts, potentially encoding 417 amino acid long proteins homologous to Rh polypeptides, were characterized, as well as mRNA isoforms which harbored nucleotide deletions or insertions and potentially encode truncated proteins. Proteins of 30-40,000 M{sub r}, immunologically related to human Rh proteins, were detected by western blot analysis with antipeptide antibodies, indicating that Rh-like transcripts are translated into membrane proteins. Comparison of human and nonhuman protein sequences was pivotal in clarifying the molecular basis of the blood group C/c polymorphism, showing that only the Pro103Ser substitution was correlated with C/c polymorphism. In addition, it was shown that a proline residue at position 102 was critical in the expression of C and c epitopes, most likely by providing an appropriate conformation of Rh polypeptides. From these data a phylogenetic reconstruction of the RH locus evolution has been calculated from which an unrooted phylogenetic tree could be proposed, indicating that African ape Rh-like genes would be closer to the human RhD gene than to the human RhCE gene. 55 refs., 4 figs., 1 tab.

  8. Well-to-wheel analysis of direct and indirect use of natural gas in passenger vehicles

    International Nuclear Information System (INIS)

    The abundance of natural gas in the United States because of the number of existing natural gas reserves and the recent advances in extracting unconventional reserves has been one of the main drivers for low natural gas prices. A question arises of what is the optimal use of natural gas as a transportation fuel. Is it more efficient to use natural gas in a stationary power application to generate electricity to charge electric vehicles, compress natural gas for onboard combustion in vehicles, or re-form natural gas into a denser transportation fuel? This study investigates the well-to-wheels energy use and greenhouse gas emissions from various natural gas to transportation fuel pathways and compares the results to conventional gasoline vehicles and electric vehicles using the US electrical generation mix. Specifically, natural gas vehicles running on compressed natural gas are compared against electric vehicles charged with electricity produced solely from natural gas combustion in stationary power plants. The results of the study show that the dependency on the combustion efficiency of natural gas in stationary power can outweigh the inherent efficiency of electric vehicles, thus highlighting the importance of examining energy use on a well-to-wheels basis. - Highlights: • Well-to-wheels analysis shows differences in use of natural gas for transportation. • Well-to-wheels approach needed to evaluate total energy use and greenhouse gas emissions. • Well-to-wheels energy and GHG (greenhouse gas) emissions depend on efficiency of the prime mover. • Efficiency of power generation critical for low GHG emissions with electric vehicles. • Fuel economy critical for low GHG emissions with compressed natural gas vehicles

  9. Thermal Analysis of the Divertor Primary Heat Transfer System Piping During the Gas Baking Process

    Energy Technology Data Exchange (ETDEWEB)

    Yoder Jr, Graydon L [ORNL; Harvey, Karen [ORNL; Ferrada, Juan J [ORNL

    2011-02-01

    A preliminary analysis has been performed examining the temperature distribution in the Divertor Primary Heat Transfer System (PHTS) piping and the divertor itself during the gas baking process. During gas baking, it is required that the divertor reach a temperature of 350 C. Thermal losses in the piping and from the divertor itself require that the gas supply temperature be maintained above that temperature in order to ensure that all of the divertor components reach the required temperature. The analysis described in this report was conducted in order to estimate the required supply temperature from the gas heater.

  10. Portable point-of-care blood analysis system for global health (Conference Presentation)

    Science.gov (United States)

    Dou, James J.; Aitchison, James Stewart; Chen, Lu; Nayyar, Rakesh

    2016-03-01

    In this paper we present a portable blood analysis system based on a disposable cartridge and hand-held reader. The platform can perform all the sample preparation, detection and waste collection required to complete a clinical test. In order to demonstrate the utility of this approach a CD4 T cell enumeration was carried out. A handheld, point-of-care CD4 T cell system was developed based on this system. In particular we will describe a pneumatic, active pumping method to control the on-chip fluidic actuation. Reagents for the CD4 T cell counting assay were dried on a reagent plug to eliminate the need for cold chain storage when used in the field. A micromixer based on the active fluidic actuation was designed to complete sample staining with fluorescent dyes that was dried on the reagent plugs. A novel image detection and analysis algorithm was developed to detect and track the flight of target particles and cells during each analysis. The handheld, point-of-care CD4 testing system was benchmarked against clinical cytometer. The experimental results demonstrated experimental results were closely matched with the flow cytometry. The same platform can be further expanded into a bead-array detection system where other types of biomolecules such as proteins can be detected using the same detection system.

  11. Bridging the gap between sample collection and laboratory analysis: using dried blood spots to identify human exposure to chemical agents

    Science.gov (United States)

    Hamelin, Elizabeth I.; Blake, Thomas A.; Perez, Jonas W.; Crow, Brian S.; Shaner, Rebecca L.; Coleman, Rebecca M.; Johnson, Rudolph C.

    2016-05-01

    Public health response to large scale chemical emergencies presents logistical challenges for sample collection, transport, and analysis. Diagnostic methods used to identify and determine exposure to chemical warfare agents, toxins, and poisons traditionally involve blood collection by phlebotomists, cold transport of biomedical samples, and costly sample preparation techniques. Use of dried blood spots, which consist of dried blood on an FDA-approved substrate, can increase analyte stability, decrease infection hazard for those handling samples, greatly reduce the cost of shipping/storing samples by removing the need for refrigeration and cold chain transportation, and be self-prepared by potentially exposed individuals using a simple finger prick and blood spot compatible paper. Our laboratory has developed clinical assays to detect human exposures to nerve agents through the analysis of specific protein adducts and metabolites, for which a simple extraction from a dried blood spot is sufficient for removing matrix interferents and attaining sensitivities on par with traditional sampling methods. The use of dried blood spots can bridge the gap between the laboratory and the field allowing for large scale sample collection with minimal impact on hospital resources while maintaining sensitivity, specificity, traceability, and quality requirements for both clinical and forensic applications.

  12. Investigating complex patterns of blocked intestinal artery blood pressure signals by empirical mode decomposition and linguistic analysis

    International Nuclear Information System (INIS)

    In this investigation, surgical operations of blocked intestinal artery have been conducted on pigs to simulate the condition of acute mesenteric arterial occlusion. The empirical mode decomposition method and the algorithm of linguistic analysis were applied to verify the blood pressure signals in simulated situation. We assumed that there was some information hidden in the high-frequency part of the blood pressure signal when an intestinal artery is blocked. The empirical mode decomposition method (EMD) has been applied to decompose the intrinsic mode functions (IMF) from a complex time series. But, the end effects and phenomenon of intermittence damage the consistence of each IMF. Thus, we proposed the complementary ensemble empirical mode decomposition method (CEEMD) to solve the problems of end effects and the phenomenon of intermittence. The main wave of blood pressure signals can be reconstructed by the main components, identified by Monte Carlo verification, and removed from the original signal to derive a riding wave. Furthermore, the concept of linguistic analysis was applied to design the blocking index to verify the pattern of riding wave of blood pressure using the measurements of dissimilarity. Blocking index works well to identify the situation in which the sampled time series of blood pressure signal was recorded. Here, these two totally different algorithms are successfully integrated and the existence of the existence of information hidden in high-frequency part of blood pressure signal has been proven

  13. Heavy metals analysis in blood by the X-ray fluorescence method

    International Nuclear Information System (INIS)

    The analytical procedure for determination of heavy metals in blood is described. Blood was taken from active smelter workers, samples were stored in special flasks at 2 grades C. After freeze drying, dried samples was analyzed using X-ray fluorescence, sources excited: Pu-238 and Cd-109 was used. Br in Pb interferences were corrected. The agreement of the results with values in similar workers is satisfactory Median Pb level was 42.6 micro grams/100 ml (total blood), Cu was less 2.5 micro grams/g (dry blood) and Zn was 11 micro grams/g (dry blood). (author)

  14. Computational Fluid Dynamics Analysis of Pulsatile Blood Flow Behavior in Modelled Stenosed Vessels with Different Severities

    OpenAIRE

    Mohsen Mehrabi; Saeed Setayeshi

    2012-01-01

    This study focuses on the behavior of blood flow in the stenosed vessels. Blood is modelled as an incompressible non-Newtonian fluid which is based on the power law viscosity model. A numerical technique based on the finite difference method is developed to simulate the blood flow taking into account the transient periodic behaviour of the blood flow in cardiac cycles. Also, pulsatile blood flow in the stenosed vessel is based on the Womersley model, and fluid flow in the lumen region is gove...

  15. PROTOCOL FOR GAS SAMPLING AND ANALYSIS IN STRANDED MARINE MAMMALS

    OpenAIRE

    sprotocols

    2015-01-01

    Authors: Yara Bernaldo de Quirós, Óscar González-Díaz, Manuel Arbelo, Marisa Andrada & Antonio Fernández ### Abstract Gas sampling in stranded marine mammals can now be performed in situ using the appropriate vacuum tubes, insulin syringes and an aspirometer. Glass vacuum tubes are used for extraction of gas from cavities such as the intestine, pterigoyd air sacs, pneumothorax or subcapsular emphysema as well as for storage of the gas sample at room temperature and pressure. Insul...

  16. GAS MIXING ANALYSIS IN A LARGE-SCALED SALTSTONE FACILITY

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S

    2008-05-28

    Computational fluid dynamics (CFD) methods have been used to estimate the flow patterns mainly driven by temperature gradients inside vapor space in a large-scaled Saltstone vault facility at Savannah River site (SRS). The purpose of this work is to examine the gas motions inside the vapor space under the current vault configurations by taking a three-dimensional transient momentum-energy coupled approach for the vapor space domain of the vault. The modeling calculations were based on prototypic vault geometry and expected normal operating conditions as defined by Waste Solidification Engineering. The modeling analysis was focused on the air flow patterns near the ventilated corner zones of the vapor space inside the Saltstone vault. The turbulence behavior and natural convection mechanism used in the present model were benchmarked against the literature information and theoretical results. The verified model was applied to the Saltstone vault geometry for the transient assessment of the air flow patterns inside the vapor space of the vault region using the potential operating conditions. The baseline model considered two cases for the estimations of the flow patterns within the vapor space. One is the reference nominal case. The other is for the negative temperature gradient between the roof inner and top grout surface temperatures intended for the potential bounding condition. The flow patterns of the vapor space calculated by the CFD model demonstrate that the ambient air comes into the vapor space of the vault through the lower-end ventilation hole, and it gets heated up by the Benard-cell type circulation before leaving the vault via the higher-end ventilation hole. The calculated results are consistent with the literature information. Detailed results and the cases considered in the calculations will be discussed here.

  17. Rapid analysis of urinary opiates using fast gas chromatography–mass spectrometry and hydrogen as a carrier gas

    Directory of Open Access Journals (Sweden)

    Sumandeep Rana

    2014-09-01

    Gas chromatographic–mass spectrometric analysis was performed in electron ionization mode by selective ion monitoring, using hydrogen as a carrier gas, a short narrow bore GC capillary column, and fast temperature program, allowing for a rapid analytical cycle to maximize the instrument time for high throughput laboratories. While maintaining specificity for these drugs, concentrations in human urine ranging from 50 to 5,000 ng/mL can be measured with intraday and interday imprecision, expressed as variation coefficients, of less than 2.3% for all analytes within a run time of less than 3.5 minutes.

  18. Biomarker Analysis of Stored Blood Products: Emphasis on Pre-Analytical Issues

    Directory of Open Access Journals (Sweden)

    Niels Lion

    2010-11-01

    Full Text Available Millions of blood products are transfused every year; many lives are thus directly concerned by transfusion. The three main labile blood products used in transfusion are erythrocyte concentrates, platelet concentrates and fresh frozen plasma. Each of these products has to be stored according to its particular components. However, during storage, modifications or degradation of those components may occur, and are known as storage lesions. Thus, biomarker discovery of in vivo blood aging as well as in vitro labile blood products storage lesions is of high interest for the transfusion medicine community. Pre-analytical issues are of major importance in analyzing the various blood products during storage conditions as well as according to various protocols that are currently used in blood banks for their preparations. This paper will review key elements that have to be taken into account in the context of proteomic-based biomarker discovery applied to blood banking.

  19. Biomarker analysis of stored blood products: emphasis on pre-analytical issues.

    Science.gov (United States)

    Delobel, Julien; Rubin, Olivier; Prudent, Michel; Crettaz, David; Tissot, Jean-Daniel; Lion, Niels

    2010-01-01

    Millions of blood products are transfused every year; many lives are thus directly concerned by transfusion. The three main labile blood products used in transfusion are erythrocyte concentrates, platelet concentrates and fresh frozen plasma. Each of these products has to be stored according to its particular components. However, during storage, modifications or degradation of those components may occur, and are known as storage lesions. Thus, biomarker discovery of in vivo blood aging as well as in vitro labile blood products storage lesions is of high interest for the transfusion medicine community. Pre-analytical issues are of major importance in analyzing the various blood products during storage conditions as well as according to various protocols that are currently used in blood banks for their preparations. This paper will review key elements that have to be taken into account in the context of proteomic-based biomarker discovery applied to blood banking. PMID:21151459

  20. Blood meal analysis of tabanid fly after it biting the rare Sumatran rhinoceros

    Institute of Scientific and Technical Information of China (English)

    Jeffrine Japning Rovie-Ryan; Zainal Zahari Zainuddin; Wahap Marni; Abdul Hamid Ahmad; Laurentius N Ambu; Junaidi Payne

    2013-01-01

    Objective: To demonstrate a noninvasive large mammalian genetic sampling method using blood meal obtained from a tabanid fly. Methods: Blood meal was recovered from the abdomen of an engorged tabanid fly (Haematopota sp.) which was captured immediately after biting a Sumatran rhino in captivity. The blood was applied on to a Whatman FTA®blood card. Subsequent laboratory work was conducted to extract, amplify and sequence the DNA from the sample. Validation was done by sampling the hair follicles and blood samples from the rhinoceros and subjecting it to the same laboratory process. Results: BLAST search and constructed phylogenetic trees confirmed the blood meal samples were indeed from the rhino. Conclusions: This method could be used in the field application to noninvasively collect genetic samples. Collection of tabanids and other haematophagous arthropods (e.g. mosquitoes and ticks) and other blood-sucking parasites (e.g. leeches and worms) could also provide information on vector-borne diseases.

  1. Interference of anesthetics in blood alcohol analysis by HS-GC-FID: A case report.

    Science.gov (United States)

    Monteiro, C; Proença, P; Tavares, C; Castañera, A; Corte Real, F

    2016-08-01

    One of the techniques most widely used in ethanol analysis in forensic laboratories is undoubtedly the headspace gas chromatography with flame-ionization detection (HS-GC-FID) since the determination of this substance is carried out directly, without the need for additional purification procedures, which leads to increased productivity. This is a very important factor due to the high number of alcohol analysis requested to these laboratories. The presence of other volatile substances can cause a problem given the fact that they can be interferents in ethanol analysis by HS-GC-FID, which can have legal consequences related with driving under the influence of alcohol. The authors report a case of a routine analysis by HS-GC-FID for the determination of ethanol of a driver who has suffered an accident in which the use of two chromatographic columns with different polarities was essential to obtain an unequivocally identification of this substance in presence of an interfering volatile anesthetic administered in the hospital. The method was validated according to international recommendations before being introduced into routine laboratory in terms of selectivity, limits of detection (LOD), limits of quantification (LOQ), linearity, repeatability, intermediate precision, accuracy, robustness and carryover. PMID:26829337

  2. ECONOMIC ANALYSIS OF GAS-TO-LIQUIDS PROJECTS IN CHINA

    Institute of Scientific and Technical Information of China (English)

    Liu Zhihong

    2001-01-01

    @@ Introduction of GTL technology Processes to convert natural gas to synthetic liquid petroleum products have been under development for more than 70 years, but only in recent years are they being seen as commercially viable.

  3. Flame Stretch Analysis in Diffusion Flames with Inert Gas

    Institute of Scientific and Technical Information of China (English)

    Ay Su; Ying-Chieh Liu

    2001-01-01

    Experimental investigations of impinging flame with fuel mixed with non-reaction gas were conducted.According to the observations of combustion test and temperature measurement, the non-reaction gas might dilute the local concentration of fuel in the diffusion process. The shape of the flame was symmetrical due to the flame stretch force. Results show that the conical flame might be de-structured by the addition of inert gas in pure methane fuel. The impinging flame became shorter and bluer as nitrogen was added to the fuel. The conditions of N2/CH4 equal to 1/2 and 1/1 show a wider plane in the YZ plane. The effect of inert gas overcomes the flame stretch and destroys the symmetrical column flame as well as the cold flow. Nitrogen addition also enhances the diffusion rate and combustion efficiency.

  4. Analysis of the Energy Balance of Shale Gas Development

    OpenAIRE

    Hiroaki Yaritani; Jun Matsushima

    2014-01-01

    Interest has rapidly grown in the use of unconventional resources to compensate for depletion of conventional hydrocarbon resources (“easy hydrocarbon†) that are produced at relatively low cost from oil and gas fields with large proven reserves. When one wants to ensure the prospects for development of unconventional resources that are potentially vast in terms of their energy potential, it is essential to determine the quality of that energy. Here we consider the development of shale gas...

  5. Technical and financial analysis of combined cycle gas turbine

    OpenAIRE

    Khan Arshad Muhammad

    2013-01-01

    This paper presents technical and financial models which were developed in this study to predict the overall performance of combined cycle gas turbine plant in line with the needs of independent power producers in the liberalized market of power sector. Three similar sizes of combined cycle gas turbine power projects up to 200 Megawatt of independent power producers in Pakistan were selected in-order to develop and drive the basic assumptions for the inputs of the models in view of prev...

  6. Risk analysis of the shale gas well testing installation

    OpenAIRE

    Jóźwik, Andrzej Krzysztof

    2015-01-01

    The primary purpose of this study was to examine what kind of threats are associated with functioning of the shale gas well testing installation, and also how failures of the installation influence the safety of the residents living nearby. With the development of the shale gas industry in Poland, the discussion about the influence of hydraulic fracturing on the social and environmental safety has been raised. This discussion neglected the risks associated with the surface operations, which t...

  7. Availability Analysis of Gas Turbines Used in Power Plants

    OpenAIRE

    Gilberto Francisco Martha de Souza; Fernando Jesus Guevara Carazas

    2009-01-01

    The availability of a complex system, such as a gas turbine, is strongly associated with its parts reliability and maintenance policy. That policy not only has influence on the parts’ repair time but also on the parts’ reliability affecting the system degradation and availability. This study presents a method for reliability and availability evaluation of gas turbines installed in an electric power station. The method is based on system reliability concepts, such as functi...

  8. Availability Analysis of Gas Turbines Used in Power Plants

    OpenAIRE

    de Souza, Gilberto Francisco Martha; Carazas, Fernando Jesus Guevara

    2009-01-01

    The availability of a complex system, such as a gas turbine, is strongly associated with its parts reliability and maintenance policy. That policy not only has influence on the parts’ repair time but also on the parts’ reliability affecting the system degradation and availability. This study presents a method for reliability and availability evaluation of gas turbines installed in an electric power station. The method is based on system reliability concepts, such as functional tre...

  9. Offsite Radiological Consequence Analysis for the Bounding Flammable Gas Accident

    CERN Document Server

    Carro, C A

    2003-01-01

    This document quantifies the offsite radiological consequences of the bounding flammable gas accident for comparison with the 25 rem Evaluation Guideline established in DOE-STD-3009, Appendix A. The bounding flammable gas accident is a detonation in a single-shell tank The calculation applies reasonably conservation input parameters in accordance with DOE-STD-3009, Appendix A, guidance. Revision 1 incorporates comments received from Office of River Protection.

  10. Modelling and analysis of offshore energy systems on North Sea oil and gas platforms

    DEFF Research Database (Denmark)

    Nguyen, Tuong-Van; Elmegaard, Brian; Pierobon, Leonardo;

    2012-01-01

    Offshore processes are associated with significant energy consumption and large CO2 emissions. Conventional North Sea oil and gas facilities include the following operations: crude oil separation, gas compression and purification, wastewater treatment, gas lifting, seawater injection, oil and gas...... export, and power generation. In this paper, a generic model of a North Sea oil and gas platform is described and the most thermodynamically inefficient processes are identified by performing an exergy analysis. Models and simulations are built and run with the tools Aspen Plus R, DNA and Aspen HYSYS R....... Results reveal that the total exergy destruction of the system is particularly sensitive to the gas-to-oil ratio and amounts to 55-65 MW, while the total exergy losses amount to 15-20 MW. The gas compression train and the production manifold module are the most exergy-destructive operations of the oil...

  11. DNA damage focus analysis in blood samples of minipigs reveals acute partial body irradiation.

    Directory of Open Access Journals (Sweden)

    Andreas Lamkowski

    Full Text Available Radiation accidents frequently involve acute high dose partial body irradiation leading to victims with radiation sickness and cutaneous radiation syndrome that implements radiation-induced cell death. Cells that are not lethally hit seek to repair ionizing radiation (IR induced damage, albeit at the expense of an increased risk of mutation and tumor formation due to misrepair of IR-induced DNA double strand breaks (DSBs. The response to DNA damage includes phosphorylation of histone H2AX in the vicinity of DSBs, creating foci in the nucleus whose enumeration can serve as a radiation biodosimeter. Here, we investigated γH2AX and DNA repair foci in peripheral blood lymphocytes of Göttingen minipigs that experienced acute partial body irradiation (PBI with 49 Gy (± 6% Co-60 γ-rays of the upper lumbar region. Blood samples taken 4, 24 and 168 hours post PBI were subjected to γ-H2AX, 53BP1 and MRE11 focus enumeration. Peripheral blood lymphocytes (PBL of 49 Gy partial body irradiated minipigs were found to display 1-8 DNA damage foci/cell. These PBL values significantly deceed the high foci numbers observed in keratinocyte nuclei of the directly γ-irradiated minipig skin regions, indicating a limited resident time of PBL in the exposed tissue volume. Nonetheless, PBL samples obtained 4 h post IR in average contained 2.2% of cells displaying a pan-γH2AX signal, suggesting that these received a higher IR dose. Moreover, dispersion analysis indicated partial body irradiation for all 13 minipigs at 4 h post IR. While dose reconstruction using γH2AX DNA repair foci in lymphocytes after in vivo PBI represents a challenge, the DNA damage focus assay may serve as a rapid, first line indicator of radiation exposure. The occurrence of PBLs with pan-γH2AX staining and of cells with relatively high foci numbers that skew a Poisson distribution may be taken as indicator of acute high dose partial body irradiation, particularly when samples are available

  12. New Jersey's natural gas shortage: a policy analysis

    Energy Technology Data Exchange (ETDEWEB)

    Cecil, J.L.; Morell, D.

    1976-12-01

    The public policy problems associated with New Jersey's natural gas shortage are extremely complex and rather difficult to examine. They involve a blend of technology, politics and economics; of regulatory mandates and profit-motivated initiatives; of Federal and state interaction and conflict. To understand the state's gas shortage and to lay the basis for recommending measures to deal with it, information about the basic technology, the organization of the gas industry, the national regulatory posture, and the possible causes of the gas shortage encompasses Part I of the overall study. In Part II, the analysis turns from the national level to a direct examination of New Jersey's gas situation. In Part III, Chapter VIII, the following are considered: the state's supply of natural gas, distribution of these supply volumes within New Jersey by the four major gas utilities, and gas consumption patterns within the state as a whole and then for each major consuming sector (electric utility, industrial, commercial, and residential). This chapter concludes with an analysis of the impacts of the gas shortage to date in New Jersey, and of its probable effects in the near-term. In the final chapter, some tentative conclusions and broad suggestions are advanced for public policies to mitigate the gravity of the state's position with respect to natural gas. Analysis proceeds, in turn, through consideration of possible state actions in several areas: increasing total interstate gas supplies; increasing New Jersey's share of whatever national total exists; making greater (or more effective) use of alternate fuels; and moderating demand for gas through aggressive conservation policies. Some short-term measures to cope better with whatever level of gas shortage exists in the state at any particular time are suggested. 151 references. (MCW)

  13. Temporal Progression of Pneumonic Plague in Blood of Nonhuman Primate: A Transcriptomic Analysis.

    Directory of Open Access Journals (Sweden)

    Rasha Hammamieh

    Full Text Available Early identification of impending illness during widespread exposure to a pathogenic agent offers a potential means to initiate treatment during a timeframe when it would be most likely to be effective and has the potential to identify novel therapeutic strategies. The latter could be critical, especially as antibiotic resistance is becoming widespread. In order to examine pre-symptomatic illness, African green monkeys were challenged intranasally with aerosolized Yersinia pestis strain CO92 and blood samples were collected in short intervals from 45 m till 42 h post-exposure. Presenting one of the first genomic investigations of a NHP model challenged by pneumonic plague, whole genome analysis was annotated in silico and validated by qPCR assay. Transcriptomic profiles of blood showed early perturbation with the number of differentially expressed genes increasing until 24 h. By then, Y. pestis had paralyzed the host defense, as suggested by the functional analyses. Early activation of the apoptotic networks possibly facilitated the pathogen to overwhelm the defense mechanisms, despite the activation of the pro-inflammatory mechanism, toll-like receptors and microtubules at the port-of-entry. The overexpressed transcripts encoding an early pro-inflammatory response particularly manifested in active lymphocytes and ubiquitin networks were a potential deviation from the rodent models, which needs further verification. In summary, the present study recognized a pattern of Y. pestis pathogenesis potentially more applicable to the human system. Independent validation using the complementary omics approach with comprehensive evaluation of the organs, such as lungs which showed early bacterial infection, is essential.

  14. Influence of rimonabant treatment on peripheral blood mononuclear cells; flow cytometry analysis and gene expression profiling

    Directory of Open Access Journals (Sweden)

    Stefan Almestrand

    2015-06-01

    Full Text Available The cannabinoid receptor type 1 (CB1 antagonist rimonabant has been used as treatment for obesity. In addition, anti-proliferative effects on mitogen-activated leukocytes have been demonstrated in vitro. We have previously shown that rimonabant (SR141716A induces cell death in ex vivo isolated malignant lymphomas with high expression of CB1 receptors. Since CB1 targeting may be part of a future lymphoma therapy, it was of interest to investigate possible effects on peripheral blood mononuclear cells (PBMC in patients treated with rimonabant. We therefore evaluated leukocyte subsets by 6 color flow cytometry in eight patients before and at treatment with rimonabant for 4 weeks. Whole-transcript gene expression profiling in PBMC before and at 4 weeks of rimonabant treatment was done using Affymetrix Human Gene 1.0 ST Arrays. Our data show no significant changes of monocytes, B cells, total T cells or T cell subsets in PBMC during treatment with rimonabant. There was a small but significant increase in CD3–, CD16+ and/or CD56+ cells after rimonabant therapy. Gene expression analysis detected significant changes in expression of genes associated with innate immunity, cell death and metabolism. The present study shows that normal monocytes and leukocyte subsets in blood remain rather constant during rimonabant treatment. This is in contrast to the induction of cell death previously observed in CB1 expressing lymphoma cells in response to treatment with rimonabant in vitro. These differential effects observed on normal and malignant lymphoid cells warrant investigation of CB1 targeting as a potential lymphoma treatment.

  15. Analysis of blood serum of lung cancer patients using particle induced X-ray emission

    International Nuclear Information System (INIS)

    Trace elemental imbalance in human beings is postulated to exert action, directly or indirectly, on the carcinogenic process. The objective of this study was to evaluate the levels of trace elements in blood serum samples of lung cancer patients and analyze their alteration with respect to healthy controls. Particle induced X-ray emission (PIXE), a well established method for elemental analysis, was used to identify and quantify trace elements in the blood serum samples of the studied groups. The PIXE measurements were carried out using 2.5 MeV collimated proton beam from the 3 MV Tandem Pelletron Accelerator at Ion Beam Laboratory, Institute of Physics, Bhubaneswar, India. The serum of the cancerous group displayed increased concentrations of Ti, Ni, and Cu but lowered concentrations of V, Cr, Mn, Fe, Co, Zn, and Se. Statistically significant differences were found for serum Cr (p < 0.01), Fe (p < 0.0005), Ni (p < 0.05), Cu (p < 0.00005), and Zn (p < 0.0005) between the two studied groups. The copper to zinc ratio for the lung cancer group was 2.24 ± 0.39, which was almost three times the value for normal subjects (0.77 ± 0.14). The observed alterations are discussed with respect to the possible mechanisms by which these elements might influence the carcinogenic process. Significant reduction in mortality from lung cancer can be achieved by advances in early diagnosis and implementation of multidisciplinary treatment programmes leading to improvement of survivorship and better quality of life. It is expected that similar studies from all corners of the world would ultimately lead to the development of novel therapeutic agents to treat lung cancer. (author)

  16. The Physics Analysis of a Gas Attenuator with Argon as a Working Gas

    Energy Technology Data Exchange (ETDEWEB)

    Ryutov,, D.D.

    2010-12-07

    A gas attenuator is an important element of the LCLS facility. The attenuator must operate in a broad range of x-ray energies, provide attenuation coefficient between 1 and 10{sup 4} with the accuracy of 1% and, at the same time, be reliable and allow for many months of un-interrupted operation. S. Shen has recently carried out a detailed design study of the attenuator based on the use of nitrogen as a working gas. In this note we assess the features of the attenuator based on the use of argon. We concentrate on the physics issues, not the design features.

  17. Extension of some numerical schemes to the analysis of gas and particle mixtures

    Energy Technology Data Exchange (ETDEWEB)

    Garcia-Cascales, J. R.; Mulas-Perez, J. [UPCT, Dept Ingn Quim Term and Fluidos, Murcia 30202, (Spain); Paillere, H. [CEA Saclay, DM2S/SFME, Lab Etudes Transferts Mecan Fluides, F-91191 Gif Sur Yvette, (France)

    2008-07-01

    In this paper, several numerical schemes are extended to obtain approximate solutions to the system of equations encountered in the analysis of multiphase mixtures of gas and particles. Both dense and dilute mixtures are studied, the gas is modelled as a perfect gas and the solid is considered incompressible. Although the tests employed throughout this work for studying the behaviour of the schemes are essentially one dimensional, the finite volume method developed permits its application to multidimensional problems in unstructured grids. (authors)

  18. Economics of Using Flared vs. Conventional Natural Gas to Produce Nitrogen Fertilizer: A Feasibility Analysis

    OpenAIRE

    Maung, Thein A.; Ripplinger, David G.; McKee, Gregory J.; Saxowsky, David M.

    2012-01-01

    The feasibility analysis begins by examining the economic potential of using flared natural gas as a feedstock to produce a low-cost, reliable, and sustainable supply of nitrogen fertilizer for North Dakota farmers. Specific objectives include • Determining the most profitable facility size, location, and configuration for a natural gas nitrogen fertilizer production facility in North Dakota. • Calculating the financial returns and capital requirements of gas-based nitrogen fertilizer product...

  19. An integrated approach for gas dispersion, gas explosion and structural impact analysis for an offshore production platform on the Dutch continental shelf

    OpenAIRE

    Korndörffer, W.; Schaap, D.; Van der Heijden, A.M.A.; Versloot, N.H.A.

    2004-01-01

    The design of an offshore gas production platform has been subjected to an extensive quantitative risk analysis in particular with regard to its resistance to gas explosions loads. It was demonstrated that integration of the physical and structural effects of a gas explosion in an early stage of the design results in a safe and economical design. Copyright 2004, Offshore Technology Conference.

  20. Theoretical analysis of metallic nanoparticles on blood flow through stenosed artery with permeable walls

    International Nuclear Information System (INIS)

    The present analysis deals with the study of physical characteristics of blood flow in the presence of stenosis and nanoparticles through a curved channel with permeable walls. Taking mild stenosis case, the governing equations for anticipated model are solved using the corresponding boundary conditions and close-form solutions have been obtained for temperature, velocity and slip velocity by using Cauchy Euler's method. The expressions for the resistance impedance and pressure gradient in the stenotic region have also been obtained and the existence of various pertinent flow parameters, mainly Darcy number, slip parameter and nanoparticles volume fraction, has been discussed through graphs. - Highlights: • Nanoparticles analysis is discussed for diverging converging and non-tapered arteries. • Resistance impedance decreases with an increase in the nanoparticles volume fraction. • Combination of curvature and stenosis shows stenosis dominant the curvature of artery. • Pressure possesses an inverse variation to the resistance with respect to tapering. • Trapping shows that the symmetry destroys due to increase in curvature of curved artery

  1. Segmentation, Reconstruction, and Analysis of Blood Thrombus Formation in 3D 2-Photon Microscopy Images

    Directory of Open Access Journals (Sweden)

    Xu Zhiliang

    2010-01-01

    Full Text Available We study the problem of segmenting, reconstructing, and analyzing the structure growth of thrombi (clots in blood vessels in vivo based on 2-photon microscopic image data. First, we develop an algorithm for segmenting clots in 3D microscopic images based on density-based clustering and methods for dealing with imaging artifacts. Next, we apply the union-of-balls (or alpha-shape algorithm to reconstruct the boundary of clots in 3D. Finally, we perform experimental studies and analysis on the reconstructed clots and obtain quantitative data of thrombus growth and structures. We conduct experiments on laser-induced injuries in vessels of two types of mice (the wild type and the type with low levels of coagulation factor VII and analyze and compare the developing clot structures based on their reconstructed clots from image data. The results we obtain are of biomedical significance. Our quantitative analysis of the clot composition leads to better understanding of the thrombus development, and is valuable to the modeling and verification of computational simulation of thrombogenesis.

  2. Theoretical analysis of metallic nanoparticles on blood flow through stenosed artery with permeable walls

    Energy Technology Data Exchange (ETDEWEB)

    Nadeem, S.; Ijaz, S., E-mail: shaguftaijaz11@yahoo.com

    2015-03-06

    The present analysis deals with the study of physical characteristics of blood flow in the presence of stenosis and nanoparticles through a curved channel with permeable walls. Taking mild stenosis case, the governing equations for anticipated model are solved using the corresponding boundary conditions and close-form solutions have been obtained for temperature, velocity and slip velocity by using Cauchy Euler's method. The expressions for the resistance impedance and pressure gradient in the stenotic region have also been obtained and the existence of various pertinent flow parameters, mainly Darcy number, slip parameter and nanoparticles volume fraction, has been discussed through graphs. - Highlights: • Nanoparticles analysis is discussed for diverging converging and non-tapered arteries. • Resistance impedance decreases with an increase in the nanoparticles volume fraction. • Combination of curvature and stenosis shows stenosis dominant the curvature of artery. • Pressure possesses an inverse variation to the resistance with respect to tapering. • Trapping shows that the symmetry destroys due to increase in curvature of curved artery.

  3. Nonlinear Seepage Model of Gas Transport in Multiscale Shale Gas Reservoirs and Productivity Analysis of Fractured Well

    Directory of Open Access Journals (Sweden)

    Ting Huang

    2015-01-01

    Full Text Available Shale is abundant in nanoscale pores, so gas flow in shales cannot be simply represented by Darcy formula anymore. It is crucial to figure out the influence of gas flow in nano/micro pores on actual productivity, which can provide basic theories for optimizing parameters and improving the gas production from engineering perspective. This paper considers the effects of slippage and diffusion in nanoscale based on Beskok-Karniadakis (BK equation, which can be applicable for different flow regimes including continuum flow, slip flow, transition flow, and free-molecule flow. A new non-Darcy equation was developed based on the analysis of effects of high order terms of BK equation on permeability correction factor. By using the conformal transformation principle and pressure coupling method, we established the productivity formula of fractured well (infinite and limited conductivity satisfying mass variable seepage flowing in fractures. The simulation results have been compared with field data and influencing parameters are analyzed thoroughly. It is concluded that slippage effect affects gas production of fractured well when wellbore pressure is less than 15 MPa, and the effects of slippage and diffusion have greater influence on gas production of fractured well for reservoir with smaller permeability, especially when permeability is at nano-Darcy scale.

  4. Development of a natural Gas Systems Analysis Model (GSAM)

    International Nuclear Information System (INIS)

    Lacking a detailed characterization of the resource base and a comprehensive borehole-to-burnertip evaluation model of the North American natural gas system, past R ampersand D, tax and regulatory policies have been formulated without a full understanding of their likely direct and indirect impacts on future gas supply and demand. The recent disappearance of the deliverability surplus, pipeline deregulation, and current policy debates about regulatory initiatives in taxation, environmental compliance and leasing make the need for a comprehensive gas evaluation system critical. Traditional econometric or highly aggregated energy models are increasingly regarded as unable to incorporate available geologic detail and explicit technology performance and costing algorithms necessary to evaluate resource-technology-economic interactions in a market context. The objective of this research is to create a comprehensive, non-proprietary, microcomputer model of the North American natural gas system. GSAM explicitly evaluates the key components of the natural gas system, including resource base, exploration and development, extraction technology performance and costs, transportation and storage and end use. The primary focus is the detailed characterization of the resource base at the reservoir and sub-reservoir level and the impact of alternative extraction technologies on well productivity and economics. GSAM evaluates the complex interactions of current and alternative future technology and policy initiatives in the context of the evolving gas markets. Scheduled for completion in 1995, a prototype is planned for early 1994. ICF Resources reviewed relevant natural gas upstream, downstream and market models to identify appropriate analytic capabilities to incorporate into GSAM. We have reviewed extraction technologies to better characterize performance and costs in terms of GSAM parameters

  5. Parametric economic analysis of natural gas reburn technologies. Topical report, June 1991-June 1992

    International Nuclear Information System (INIS)

    The report presents a parametric economic analysis of natural gas reburn technologies used for control of nitrogen oxides emissions in coal-fired utility boilers. It is a competitive assessment of the economics of gas reburn performed in the context of regulatory requirements and competing conventional technologies. The reburn technologies examined are basic gas reburn, reburn with sorbent injection and advanced gas reburn. The analysis determined the levelized costs of these technologies in $/ton of NOx removed with respect to a gas-coal price differential in $/MMBtu of energy input. For those niches in which reburn was less economical, a breakeven capital cost analysis was carried out to determine the R ampersand D goals which would make reburn more cost competitive

  6. Energy Factor Analysis for Gas Heat Pump Water Heaters

    Energy Technology Data Exchange (ETDEWEB)

    Gluesenkamp, Kyle R [ORNL

    2016-01-01

    Gas heat pump water heaters (HPWHs) can improve water heating efficiency with zero GWP and zero ODP working fluids. The energy factor (EF) of a gas HPWH is sensitive to several factors. In this work, expressions are derived for EF of gas HPWHs, as a function of heat pump cycle COP, tank heat losses, burner efficiency, electrical draw, and effectiveness of supplemental heat exchangers. The expressions are used to investigate the sensitivity of EF to each parameter. EF is evaluated on a site energy basis (as used by the US DOE for rating water heater EF), and a primary energy-basis energy factor (PEF) is also defined and included. Typical ranges of values for the six parameters are given. For gas HPWHs, using typical ranges for component performance, EF will be 59 80% of the heat pump cycle thermal COP (for example, a COP of 1.60 may result in an EF of 0.94 1.28). Most of the reduction in COP is due to burner efficiency and tank heat losses. Gas-fired HPWHs are theoretically be capable of an EF of up to 1.7 (PEF of 1.6); while an EF of 1.1 1.3 (PEF of 1.0 1.1) is expected from an early market entry.

  7. Uranium enrichment using gas centrifugation. An analysis focusing export control

    International Nuclear Information System (INIS)

    The Swedish Defence Research Agency, FOI, has performed a study on uranium enrichment by gas centrifugation. The theory and principles of gas centrifugation is described in this report and relevant equipment used in the process has been identified. Different aspects of operating a gas centrifuge facility - and its indicators - are also presented. The separation efficiency and the flow of material through a centrifuge are very small, and therefore, a large number of centrifuges in cascades is needed to produce a larger amount of enriched uranium within a reasonable time. Countries with nuclear weapons ambitions often show an interest in gas centrifuges to produce weapons grade uranium - if they have managed to acquire the technology - because of the efficiency of the process and since it is relatively easy to conceal. Most equipment used in gas centrifuge facilities is under export control to prevent clandestine uranium enrichment. The Nuclear Suppliers' Group has compiled lists of nuclear related equipment and components that are of importance to export control. The control lists have also been included in the EU legislation

  8. Molecular genetic and physical analysis of gas vesicles in buoyant enterobacteria.

    Science.gov (United States)

    Tashiro, Yosuke; Monson, Rita E; Ramsay, Joshua P; Salmond, George P C

    2016-04-01

    Different modes of bacterial taxis play important roles in environmental adaptation, survival, colonization and dissemination of disease. One mode of taxis is flotation due to the production of gas vesicles. Gas vesicles are proteinaceous intracellular organelles, permeable only to gas, that enable flotation in aquatic niches. Gene clusters for gas vesicle biosynthesis are partially conserved in various archaea, cyanobacteria, and some proteobacteria, such as the enterobacterium, Serratia sp. ATCC 39006 (S39006). Here we present the first systematic analysis of the genes required to produce gas vesicles in S39006, identifying how this differs from the archaeon Halobacterium salinarum. We define 11 proteins essential for gas vesicle production. Mutation of gvpN or gvpV produced small bicone gas vesicles, suggesting that the cognate proteins are involved in the morphogenetic assembly pathway from bicones to mature cylindrical forms. Using volumetric compression, gas vesicles were shown to comprise 17% of S39006 cells, whereas in Escherichia coli heterologously expressing the gas vesicle cluster in a deregulated environment, gas vesicles can occupy around half of cellular volume. Gas vesicle production in S39006 and E. coli was exploited to calculate the instantaneous turgor pressure within cultured bacterial cells; the first time this has been performed in either strain. PMID:26743231

  9. Gas chromatographic-mass spectrometric analysis of tar compounds formed during pyrolysis of rice husks

    NARCIS (Netherlands)

    Haanappel, V.A.C.; Stevens, T.W.; Hovestad, A.; Skolnik, V.; Visser, R.

    1991-01-01

    Pyrolysis of agricultural waste to produce fuel gas involves formation of tars as noxious by-products. In this paper the qualitative analysis of tars formed during pyrolysis of rice husks is presented, based on identification by gas chromatography—mass spectrometry and interpolation of retention tim

  10. Analysis of Turkish High School Chemistry Textbooks and Teacher-Generated Questions about Gas Laws

    Science.gov (United States)

    Nakiboglu, Canan; Yildirir, H.

    2011-01-01

    This study presents the results of an analysis of high school chemistry textbooks and teacher-generated questions about gas laws. The materials that were analyzed consisted of 456 questions about gas laws found in seven grade 10 chemistry textbooks and 264 teacher-generated examination questions prepared by seven chemistry teachers from three…

  11. Sensitivity analysis and model type evaluation for subsidence above offshore gas reservoirs

    NARCIS (Netherlands)

    Pruiksma, J.P.; Teunissen, J.A.M.; Barends, F.B.J.; Orlic, B.; Cassiani, G.

    2005-01-01

    This paper describes the results of a sensitivity study conducted to understand how the prediction of subsidence due to gas extraction from offshore gas fields depends on a few key parameters, such as connection to the adjacent aquifers and material mechanical properties. The analysis has been perfo

  12. Analysis of inorganic elements in blood of albino rabbit using NAA

    Energy Technology Data Exchange (ETDEWEB)

    Metairon, Sabrina; Zamboni, Cibele B.; Medeiros, Ilca M.M.A., E-mail: metairon@live.co [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2009-07-01

    In this work Br, Cl, K and Na concentrations in albino rabbit blood were determinate using NAA. They are the first indicative interval for reference values in whole blood and they could be used for checking the clinical status of this specie when it will be used was animal model. The results when compared with human whole blood estimation suggest compatibility for Br, Cl and K considering 95% of confidence interval but, for Na the levels are altered, suggesting physiologic differences. (author)

  13. Analysis of discard of whole blood and its components with suggested possible strategies to reduce it

    Directory of Open Access Journals (Sweden)

    Parikshit Patil

    2016-02-01

    Conclusions: Platelets were the most commonly discarded blood component due to short shelf life and non utilization in time as demand cannot be predicted. In our study the main reason for discarding whole blood and Packed Red Cells was sero-positivity for various Transfusion Transmitted Infections while non utilization after issue, breakage/leakage were the main reasons for Fresh Frozen Plasma discard. The self audit of blood transfusion service provides insight into current blood transfusion practices prevalent in the hospital. [Int J Res Med Sci 2016; 4(2.000: 477-481

  14. Analysis of adverse events and predisposing factors in voluntary and replacement whole blood donors: A study from north India

    Directory of Open Access Journals (Sweden)

    Naveen Agnihotri

    2012-01-01

    Full Text Available Background: Lack of awareness and community motivation, compounded with fragmented blood transfusion services in our country, Often leads to shortage of blood. Donor recruitment and retention are essential for ensuring adequate blood supply. However, adverse events (AEs in donors have a negative impact on donor return. Aims and Objectives: The present study was aimed to assess the frequency of AEs in whole blood donors and analyze the predisposing factors for AEs. Material and Methods: The study was conducted on allogeneic whole blood donors over a period of 14 months, i.e., from January 2002 to February 2003. A total of 37,896 donors were monitored for any AEs: 22587 (59.6% were voluntary donors (VD and 15,309 (40.4% were replacement donors (RD. Results: Overall reaction rate was 2.5% with vasovagal reactions constituting 63.5% and hematomas 35.0% of all reactions. Vasovagal reactions showed a significant association with young age, lower weight, first time donation status, female gender, and nature of blood donation camps. Amongst male donors, RDs had more reactions (P=0.03 than VDs. Majority of donors (85% with vasovagal reactions admitted to some fear or anxiety prior to donation. Hematoma formation occurred significantly more when less trained staff performed phlebotomy. Conclusion: Donor safety is an essential prerequisite to increase voluntary blood donation. AE analysis helps in identifying the blood donors at risk of donor reactions and adopting appropriate donor motivational strategies, pre-donation counseling, and care during and after donation.

  15. Explosion and fire analysis of the Dora gas storage tanks

    International Nuclear Information System (INIS)

    Full text.The location of the Dora natural gas storage tanks within a close proximity to densely populated areas necessitates a thorough study of the risk associated with accidental gas releases and potential subsequent explosions. This paper describes the type and mechanism of release, the explosion form, the ensuing severity and the areas that are correspondingly affected. A variety of leakage scenarios are explored using mathematical models that simulate gas discharge, liquid leaks and two-phase gaseous and liquid streams. Relevant explosion models are discussed covering confined explosions, unconfined vapor cloud explosions, boiling liquid expanding vapor explosions and pool fires including the identification of the elements necessary for fire initiation. Fire explosion damages and influencing factors are then presented with the purpose of effecting a thorough reflection on damage extent. Finally, hazard control programs are defined on the basis of hazard priorities among the likely scenarios

  16. Optical Absorption Spectroscopy for Gas Analysis in Biomass Gasification

    DEFF Research Database (Denmark)

    Grosch, Helge

    Biomass gasication as a source of heat, power and chemical feedstock needs monitoring of the gas species to improve the performance and gas quality, deepen the understanding of the process and to be able to control the emission of hazardous compounds. Major species, like H2, CO and CO2, can already...... be determined with sucient precision. However, minor species, like organic, aromatic, sulfur- and nitrogen-containing compounds, still cause problems in down-stream equipment and are harmful for health and environment. As a result, many different approaches for applications have been proposed to...... and aromatic compounds were determined in laboratory experiments. By means of the laboratory results and spectroscopic databases,the concentrations of the major gas species and the aromatic compounds phenol and naphthalene were determined in extraction and in-situ measurements....

  17. Electrically tuneable micromachined fabry-perot interferometer in gas analysis

    Science.gov (United States)

    Blomberg, M.; Torkkeli, A.; Lehto, A.; Helenelund, Ch; Viitasalo, M.

    1997-01-01

    This paper describes an optical gas concentration measurement system, which is based on an electrically tuneable micromachined Fabry-Perot interferometer (FPI). The operating principle of the system is NDIR Single-Beam Dual-Wavelength measurement. The FPI is tuned so that the pass band coincides with the absorption band of the measured gas; a detector records the strength of the signal getting through the measurement chamber. The pass band of the FPI is then shifted to either side of the absorption band; the detected signal constitutes the reference signal. The ratio of these two signals indicates the degree of light absorption and so the gas concentration. Properties of the FPI are discussed, as well as the performance of the measurement system.

  18. Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.

    Directory of Open Access Journals (Sweden)

    Pallav Bhatnagar

    Full Text Available In pediatric sickle cell disease (SCD patients, it has been reported that higher systolic blood pressure (SBP is associated with increased risk of a silent cerebral infarction (SCI. SCI is a major cause of neurologic morbidity in children with SCD, and blood pressure is a potential modulator of clinical manifestations of SCD; however, the risk factors underlying these complications are not well characterized. The aim of this study was to identify genetic variants that influence SBP in an African American population in the setting of SCD, and explore the use of SBP as an endo-phenotype for SCI. We conducted a genome-wide meta-analysis for SBP using two SCD cohorts, as well as a candidate screen based on published SBP loci. A total of 1,617 patients were analyzed, and while no SNP reached genome-wide significance (P-value<5.0 x 10(-8, a number of suggestive candidate loci were identified. The most significant SNP, rs7952106 (P-value=8.57 x 10(-7, was in the DRD2 locus on chromosome 11. In a gene-based association analysis, MIR4301 (micro-RNA4301, which resides in an intron of DRD2, was the most significant gene (P-value=5.2 x 10(-5. Examining 27 of the previously reported SBP associated SNPs, 4 SNPs were nominally significant. A genetic risk score was constructed to assess the aggregated genetic effect of the published SBP variants, demonstrating a significant association (P=0.05. In addition, we also assessed whether these variants are associated with SCI, validating the use of SBP as an endo-phenotype for SCI. Three SNPs were nominally associated, and only rs2357790 (5' CACNB2 was significant for both SBP and SCI. None of these SNPs retained significance after Bonferroni correction. Taken together, our results suggest the importance of DRD2 genetic variation in the modulation of SBP, and extend the aggregated importance of previously reported SNPs in the modulation of SBP in an African American cohort, more specifically in children with SCD.

  19. Meta-analysis of timolol on diurnal and nighttime intraocular pressure and blood pressure.

    LENUS (Irish Health Repository)

    Lee, Princeton Wen-Yuan

    2012-02-01

    PURPOSE: To evaluate the nighttime intraocular pressure (IOP) and blood pressure (BP) response to timolol treatment in patients with ocular hypertension or primary open-angle glaucoma. METHODS: This was a meta-analysis of previously published studies that must have been randomized, prospective, crossover or parallel, single or double-masked trials. The treatment period must have been >\\/=2 weeks with >\\/=19 patients per treatment arm for a crossover, and >\\/=50 patients for a parallel designed trial. Studies must have included both baseline and treated 24-hour curves. RESULTS: For the IOP analysis, we included 8 articles with 340 patients. A reduction from baseline was observed for timolol at each time point and for the 24-hour curve (p<\\/=0.009). When 2 studies, in which timolol was used adjunctively, were removed, a similar difference was observed as above at each time point and for the 24-hour curve (p<\\/=0.003). In 2 studies, there were small reductions from baseline for the mean diastolic and systolic BPs at most time points and for the 24-hour curve (3.9 and 4.2 mmHg, respectively) with timolol treatment. The ocular perfusion pressure did not show any difference between baseline and timolol treatment at any time point or for the 24-hour curve (p>0.05). CONCLUSIONS: This meta-analysis suggests that topical timolol therapy provides an ocular hypotensive effect over the 24-hour curve, including the nighttime hours, and while small reductions in the systolic and diastolic pressures occur, the ocular perfusion pressure is not altered over 24 hours.

  20. Analysis of engineering cycles power, refrigerating and gas liquefaction plant

    CERN Document Server

    Haywood, R W

    1991-01-01

    Extensively revised, updated and expanded, the fourth edition of this popular text provides a rigorous analytical treatment of modern energy conversion plant. Notable for both its theoretical and practical treatment of conventional and nuclear power plant, and its studies of refrigerating and gas-liquefaction plant. This fourth edition now includes material on topics of increasing concern in the fields of energy 'saving' and reduction of environmental pollution. This increased coverage deals specifically with the following areas: CHP (cogeneration) plant, studies of both gas and coal burning p

  1. Second Law Analysis of a Gas-Liquid Absorption Film

    Directory of Open Access Journals (Sweden)

    Nejib Hidouri

    2013-01-01

    Full Text Available This paper reports an analytical study of the second law in the case of gas absorption into a laminar falling viscous incompressible liquid film. Velocity, temperature, and concentration profiles are determined and used for the entropy generation calculation. Irreversibilities due to heat transfer, fluid friction, and coupling effects between heat and mass transfer are derived. The obtained results show that entropy generation is mainly due to coupling effects between heat and mass transfer near the gas-liquid interface. Total irreversibility is minimum at the diffusion film thickness. On approaching the liquid film thickness, entropy generation is mainly due to viscous irreversibility.

  2. Analysis of volatile phase transport in soils using natural radon gas as a tracer

    International Nuclear Information System (INIS)

    We have conducted a field study of soil gas transport processes using radon gas as a naturally occurring tracer. The experiment monitored soil gas radon activity, soil moisture, and soil temperature at three depths in the shallow soil column; barometric pressure, rainfall and wind speed were monitored at the soil surface. Linear and multiple regression analysis of the data sets has shown that the gas phase radon activities under natural environmental conditions are influenced by soil moisture content, barometric pressure variations, soil temperature and soil structure. The effect of wind speed on subsurface radon activities under our field conditions has not been demonstrated

  3. Natural gas engineering and safety challenges downstream process, analysis, utilization and safety

    CERN Document Server

    Nasr, GG

    2014-01-01

    Provides a critical and extensive compilation of the downstream processes of natural gas that involve the principle of gas processing , transmission and distribution, gas flow and network analysis, instrumentation and measurement systems and its utilisation Enriches understanding of the business and management aspects of natural gas as well as highlighting some of the recent research and innovations in the field Covers the needs of practising engineers from different disciplines, who may include project managers, planning and design engineers - the book is also suitable for the demands of u

  4. CFD Analysis of NOx Emissions of a Natural Gas Lean Premixed Burner for Heavy Duty Gas Turbine

    OpenAIRE

    Andreini, A.; Cerutti, M; B. Facchini; Innocenti, A.

    2015-01-01

    The present work presents a numerical analysis of a low NOx partially premixed burner for heavy duty gas turbine. The first part of the paper is focused on the study of the premixing process inside the burner using standard RANS CFD approach. The resulting profiles at different test points have been used to perform reactive simulations of an experimental test rig, where exhaust NOx emissions were measured. A reliable numerical setup was found comparing predicted and measured NOx emissions at ...

  5. Trends of Blood and Plasma Donations in Kazakhstan: 12-Years Retrospective Analysis.

    Directory of Open Access Journals (Sweden)

    Nurbek Igissinov

    2014-05-01

    Full Text Available Each country faces a continuing challenge to collect enough blood to meet the national needs. According to WHO, there should be at least 20 blood donations per 1,000 population for developing countries, in Kazakhstan this indicator was only 16.8 in 2011. Thus, we conducted an epidemiological assessment and drew a map of the regional distribution of blood and plasma donations in Kazakhstan during the years 2000-2011.The retrospective study was conducted from 2000 to 2011. Data on blood and its components donations were acquired from the Ministry of Health (annual statistical reporting form N° 39.During 2000-2011, number of blood donors decreased to 17.4% and blood donations to 6.3%. The proportion of non-remunerated blood donations and donors decreased from 97.6% to 77.9% and 97.9% to 87.7%, respectively. The paid donations had the opposite trend. Number of plasma donors increased in 2.1 times, plasma donations in 2.4 times, nevertheless the proportion of non-remunerated plasma donations decreased from 60.1% to 29.8%. The average number of blood donations per 1,000 population decreased from 19.8 (2000 to 16.8 (2011, plasma donations increased from 1.4 to 3.1. Regionally, annual average rates of blood and plasma donations per 1,000 population over 12 years varied greatly.This is the first study conducted in Kazakhstan to provide detailed information, including the regional characteristics of blood and plasma donations over an extended period of time, which can be used in blood transfusion services work.

  6. Prediction of bubble point solution gas/oil ratio in the absence of a PVT analysis

    Energy Technology Data Exchange (ETDEWEB)

    Elmabrouk, S. [University of Regina, Saskatchewan (Canada). Faculty of Engineering and Applied Science. Petroleum System Engineering; University of Tripoli (Libya). Faculty of Engineering. Petroleum Engineering Dept.], e-mail: saber_elmabrouk@yahoo.com; Shirif, E. [University of Regina, Saskatchewan (Canada). Faculty of Engineering and Applied Science. Petroleum System Engineering], E-mail: ezeddin.shirif@uregina.ca

    2011-10-15

    Several published correlations used to estimate the bubble point pressure and the bubble point oil formation volume factor of reservoir oils require that the value of the bubble point solution gas/oil ratio be one of the input variables. Consequently, engineers resort to an additional correlation in order to estimate this value. The majority of the published bubble point solution gas/oil ratio correlations are functions of bubble point pressure and gas gravity, which can be obtained either experimentally (pressure-volume-temperature, PVT analysis) or estimated from the existing correlations. Thus, it is difficult to apply the correlations in the absence of a PVT analysis. In this study, a multiple regression analysis technique was applied to develop two novel correlations to estimate the bubble point solution gas/oil ratio and stock-tank vent gas/oil ratio in the absence of a PVT analysis. The developed correlations can be directly applied by using readily available field data, thus, forgoing the requirement of additional correlations or a PVT analysis. The bubble point solution gas/oil ratio correlation is related to the separator gas-oil ratio, to the separator pressure, and to the stock-tank oil specific gravity. However, separator pressure and temperature with the stock-tank oil specific gravity were the only independent variables used in stock-tank vent gas/oil ratio correlation. Another additional and important application of the proposed stock-tank vent gas/oil ratio correlation was to estimate the stock-tank vent gas flow rate. (author)

  7. Analysis of chemical signals in red fire ants by gas chromatography and pattern recognition techniques

    Science.gov (United States)

    The combination of gas chromatography and pattern recognition (GC/PR) analysis is a powerful tool for investigating complicated biological problems. Clustering, mapping, discriminant development, etc. are necessary to analyze realistically large chromatographic data sets and to seek meaningful relat...

  8. Off-Gas Analysis During the Vitrification of Hanford Radioactive Waste Samples

    International Nuclear Information System (INIS)

    This paper describes the off-gas analysis of samples collected during the radioactive vitrification experiments. Production and characterization of the Hanford waste-containing LAW and HAW glasses are presented in related reports from this conference

  9. A numerical model of blood oxygenation during veno-venous ECMO: analysis of the interplay between blood oxygenation and its delivery parameters.

    Science.gov (United States)

    Messai, Elmi; Bouguerra, Abdesselam; Harmelin, Guy; Di Lascio, Gabriella; Bonizzoli, Manuela; Bonacchi, Massimo

    2016-06-01

    Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is an important tool in the management of most severe forms of acute respiratory failure. The determinants and management of oxygen delivery in patients treated with VV-ECMO is a complex topic. The physiological principles of oxygenation on VV-ECMO are reviewed in many textbooks. However a numerical model is an additional instrument to be used in understanding and exploring this intricate subject matter. We present a numerical model of blood oxygenation during VV-ECMO. Using this model we examined the role and impact of each determinant on blood oxygenation. The numerical analysis of variation and interplay between each oxygenation determinants during VV-ECMO is presented in graphical form. These results corroborate all the findings of previous studies. The proposed numerical model facilitates understanding of oxygenation physiology during VV-ECMO; it can be used for a medical simulation system and for teaching the principles of oxygenation during VV-ECMO. PMID:26091774

  10. [Analysis of cracking gas compressor fouling by pyrolysis gas chromatography-mass spectrometry].

    Science.gov (United States)

    Hu, Yunfeng; Fang, Fei; Wei, Tao; Liu, Shuqing; Jiang, Guangshen; Cai, Jun

    2013-06-01

    The fouling from the different sections of the cracked gas compressor in Daqing Petrochemical Corporation was analyzed by pyrolysis gas chromatography-mass spectrometry (Py/GC-MS). All the samples were cracked in RJ-1 tube furnace cracker at the cracking temperature of 500 degrees C, and separated with a 60 m DB-1 capillary column. An electron impact ionization (EI) source was used with the ionizing voltage of 70 eV. The results showed the formation of fouling was closely related with cyclopentadiene which accounted for about 50% of the cracking products. Other components detected were 1-butylene, propylene, methane and n-butane. This Py/GC-MS method can be used as an effective approach to analyze the causes of fouling in the petrochemical plants. PMID:24063202

  11. Uptitrating amlodipine significantly reduces blood pressure in diabetic patients with hypertension: a retrospective, pooled analysis

    Directory of Open Access Journals (Sweden)

    Jeffers BW

    2014-11-01

    Full Text Available Barrett W Jeffers, Rahul Bhambri, Jeffery Robbins Pfizer Inc., New York, NY, USA Abstract: Diabetic patients with hypertension are approximately twice as likely to develop cardiovascular disease as non-diabetic patients with hypertension. Given that hypertension affects ~60% of patients with diabetes, effective blood pressure (BP management is important in this high-risk population. This post-hoc analysis pooled data from six clinical studies to quantify additional BP efficacy achieved when titrating hypertensive diabetic patients from amlodipine 5 mg to 10 mg. Approximately half of the diabetic patients were male (44/98; 44.9% with a mean (standard deviation [SD] age of 60.6 (9.6 years and a baseline mean (standard error [SE] systolic blood pressure/diastolic blood pressure (SBP/DBP of 150.8 (1.30/87.5 (0.94 mmHg while on amlodipine 5 mg (159.1 [1.40]/92.6 [0.94] mmHg prior to treatment. In comparison, 350/610 (57.4% non-diabetic patients were male with a mean (SD age of 58.7 (11.1 years and baseline mean (SE SBP/DBP of 150.3 (0.62/90.9 (0.41 mmHg while on amlodipine 5 mg (160.0 [0.67]/96.2 [0.45] mmHg prior to treatment. Increasing amlodipine from 5 mg to 10 mg lowered sitting SBP by -12.5 mmHg (95% confidence interval (CI: -15.5, -9.5; P<0.0001 and DBP by -6.0 mmHg (-7.4, -4.6; P<0.0001 in diabetic patients; and SBP by -12.4 mmHg (-13.5, -11.3; P<0.0001 and DBP by -7.3 mmHg (-8.0, -6.7; P<0.0001 in non-diabetic patients. In total, 12.0% (95% CI: 6.4, 20.0 of diabetic patients achieved their BP goal versus 46.4% (42.4, 50.4 of non-diabetic patients after titration to amlodipine 10 mg. Overall, 22.0% of diabetic patients experienced 31 adverse events (AEs and 28.9% of non-diabetic patients experienced 282 AEs. Serious AEs were reported by one (1.0% diabetic and five (0.8% non-diabetic patients. In this analysis, increasing amlodipine from 5 mg to 10 mg produced a clinically significant reduction in the BP of diabetic hypertensive patients

  12. Analysis of plasma jets generated in gas and gas-water torches

    Czech Academy of Sciences Publication Activity Database

    Kavka, Tetyana; Kopecký, Vladimír; Sember, Viktor; Mašláni, Alan; Chumak, Oleksiy

    2007-01-01

    Roč. 11, č. 1 (2007), s. 59-70. ISSN 1093-3611. [High Technology Plasma Processes/9th./. Petrohrad, 29.05.2006-02.06.2006] R&D Projects: GA ČR GA202/05/0669 Institutional research plan: CEZ:AV0Z20430508 Keywords : thermal plasma jet * turbulent jet * entrainment Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 0.268, year: 2007

  13. Methods to optimize myxobacterial fermentations using off-gas analysis

    Directory of Open Access Journals (Sweden)

    Hüttel Stephan

    2012-05-01

    Full Text Available Abstract Background The influence of carbon dioxide and oxygen on microbial secondary metabolite producers and the maintenance of these two parameters at optimal levels have been studied extensively. Nevertheless, most studies have focussed on their influence on specific product formation and condition optimization of established processes. Considerably less attention has been paid to the influence of reduced or elevated carbon dioxide and oxygen levels on the overall metabolite profiles of the investigated organisms. The synergistic action of both gases has garnered even less attention. Results We show that the composition of the gas phase is highly important for the production of different metabolites and present a simple approach that enables the maintenance of defined concentrations of both O2 and CO2 during bioprocesses over broad concentration ranges with a minimal instrumental setup by using endogenously produced CO2. The metabolite profiles of a myxobacterium belonging to the genus Chondromyces grown under various concentrations of CO2 and O2 showed considerable differences. Production of two unknown, highly cytotoxic compounds and one antimicrobial substance was found to increase depending on the gas composition. In addition, the observation of CO2 and O2 in the exhaust gas allowed optimization and control of production processes. Conclusions Myxobacteria are becoming increasingly important due to their potential for bioactive secondary metabolite production. Our studies show that the influence of different gas partial pressures should not be underestimated during screening processes for novel compounds and that our described method provides a simple tool to investigate this question.

  14. Analysis of tubes filled with charged electron gas

    OpenAIRE

    Karrmann, Stefan

    2011-01-01

    We show that tubes filled with electron gas, as presented by A.Bolonkin, are not possible with current materials. First, the pressure of the charges on the outer surface cancel almost all of the electrostatic pressure of the inner electrons. Second, due to the mutually repulsion most of the electrons are in the outmost shell of the tube and not individually free.

  15. Strategic analysis on establishing a natural gas trading hub in China

    Directory of Open Access Journals (Sweden)

    Xiaoguang Tong

    2014-12-01

    Full Text Available Since 2010, the LNG importing price premium in the Asia–Pacific markets has become increasingly high, generating great effects on the economic development in China. In addition, the natural gas dependence degree is expanding continuously, making it extremely urgent to establish a natural gas trading hub in China, with the aim to ensure national energy security, to gain the pricing power, and to build the regional benchmark prices. Through a comparative analysis of internal strength/weakness and external competitiveness, we concluded that with intensively-issued supporting policies on the natural gas sector, the initiation of spot and futures markets, the rapid growth of gas production and highly-improved infrastructures, as well as Shanghai's advantageous location, China has more advantages in establishing an Asian Natural Gas Trading Hub than other counties like Singapore, Japan and Malaysia. Moreover, based on the SWOT (strength, weakness, opportunity and threat and the marketization process analysis, the following strategies were presented: to impel the establishment of a natural gas trading hub depending on the gas supply condition, to follow the policies to complete the gas storage system, to form regional communities by taking comparative advantages, and to reinforce the marketization reform and regulation system establishment with foreign experiences for reference. This study rationalized the necessity and practicality of establishing a natural gas trading hub in China and will help China make a proper decision and find a periodical strategic path in this sector.

  16. Feasibility analysis of co-fired combined-cycles using biomass-derived gas and natural gas

    International Nuclear Information System (INIS)

    This paper reports the feasibility analysis of co-fired combined cycles (biomass-derived gas + natural gas) based on the gasification of sugarcane residues (bagasse and trash). Performance results are based on simulation of co-fired combined cycles. Feasibility analysis is based on estimates of the capital costs and O and M costs for such cycles, taking into account current and middle term costs of BIG-CC technology (both considering scaling and learning effects). A deep reduction of the investments regarding the gasification island and auxiliaries is a key point to make BIG-CC competitive in the electricity market, and the required learning can be reached with co-fired BIG-CC systems. Besides alleviation of technical problems related to gas turbine operation with biomass-derived gas, co-fired BIG-CC units can operate with relative flexibility regarding the fuel mix. The construction of 10-15 short- to medium-size gasification islands would be enough to induce important cost reductions due to learning effects. As long as the investment on the gasification island is reduced, and depending on the price ratio of natural gas and biomass, pure BIG-CC plants could achieve a reasonable level of feasibility regarding other options of electricity production. In the short run there is no advantage for co-fired combined cycles regarding the costs of reduction of carbon dioxide emissions, but in the middle run both co-fired and pure BIG-CC power plants can be a better option than capture and storage of CO2

  17. Reference values comparisons between DMD and C57B whole blood mice using neutron activation analysis

    International Nuclear Information System (INIS)

    Full text: In health area animal models are used to perform clinical investigations, for example, to test new medicines for medical diagnostic and treatment investigations before to be applied in human being. Currently, the conventional bio chemistries analyses are performed using serum, but when small size animal model is involved the biological material can be scarce restricting its collection. In the last years the NAA has been successfully applied at LEER at IPEN for investigation of several elements in blood of small sized animals, resulting in an efficiency procedure for clinical practice. The advantage in using whole blood is relate to the fact that this nuclear procedure needs small quantity of biological material (10 to 100 ?L of whole blood ) when compared with the conventional analyses (0.5 to 1.0 ml of serum). But, to use whole blood to perform these biochemistry investigations it is essential to establish the reference value in blood for the species or animal models. In this study we intend to evaluate a normal range of Br, Ca, Cl, K, Mg and Na concentrations in whole blood using NAA in samples of DMDmdx and C57B/6J mice model used for muscular dystrophy investigations. Thirty whole blood samples were analyzed in the IEA R1- nuclear reactor at IPEN (Sao Paulo, Brazil). These data contribute for applications in veterinary medicine related to biochemistry analyses using whole blood. (author)

  18. Cross-matched blood for major head and neck surgery: an analysis of requirements.

    Science.gov (United States)

    Fordyce, A M; Telfer, M R; Stassen, L F

    1998-04-01

    We retrospectively analysed our blood ordering practice; the number of units of cross-matched blood requested was compared with the number transfused, in 70 patients undergoing a total of 82 ablative operations for malignant disease. Patients undergoing neck dissection alone, or excision of tumour with free revascularized flap reconstruction without neck dissection, are unlikely to require blood transfusion. Operations that include excision of tumour with primary closure and neck dissection, excision of tumour with pedicled flap reconstruction and excision of tumour with any form of flap reconstruction and neck dissection in continuity, will probably require transfusion. If atypical antibodies are present in the patient's serum on screening, cross-matched blood should always be available preoperatively. Provided that atypical antibodies are not present and that blood is available within 40 minutes from the blood bank, our results show that it is safe to adopt a policy of blood grouping and saving serum, for patients undergoing neck dissection alone, but cross-matching two or more units of blood for patients who are to have more extensive operations. PMID:9643594

  19. Numerical analysis of the internal flow field in screw centrifugal blood pump based on CFD

    Science.gov (United States)

    Han, W.; Han, B. X.; Y Wang, H.; Shen, Z. J.

    2013-12-01

    As to the impeller blood pump, the high speed of the impeller, the local high shear force of the flow field and the flow dead region are the main reasons for blood damage. The screw centrifugal pump can effectively alleviate the problems of the high speed and the high shear stress for the impeller. The softness and non-destructiveness during the transfer process can effectively reduce the extent of the damage. By using CFD software, the characteristics of internal flow are analyzed in the screw centrifugal pump by exploring the distribution rules of the velocity, pressure and shear deformation rate of the blood when it flows through the impeller and the destructive effects of spiral blades on blood. The results show that: the design of magnetic levitation solves the sealing problems; the design of regurgitation holes solves the problem of the flow dead zone; the magnetic levitated microcirculation screw centrifugal pump can effectively avoid the vortex, turbulence and high shear forces generated while the blood is flowing through the pump. Since the distribution rules in the velocity field, pressure field and shear deformation rate of the blood in the blood pump are comparatively uniform and the gradient change is comparatively small, the blood damage is effectively reduced.

  20. Computational Fluid Dynamics Analysis of Pulsatile Blood Flow Behavior in Modelled Stenosed Vessels with Different Severities

    Directory of Open Access Journals (Sweden)

    Mohsen Mehrabi

    2012-01-01

    Full Text Available This study focuses on the behavior of blood flow in the stenosed vessels. Blood is modelled as an incompressible non-Newtonian fluid which is based on the power law viscosity model. A numerical technique based on the finite difference method is developed to simulate the blood flow taking into account the transient periodic behaviour of the blood flow in cardiac cycles. Also, pulsatile blood flow in the stenosed vessel is based on the Womersley model, and fluid flow in the lumen region is governed by the continuity equation and the Navier-Stokes equations. In this study, the stenosis shape is cosine by using Tu and Devil model. Comparing the results obtained from three stenosed vessels with 30%, 50%, and 75% area severity, we find that higher percent-area severity of stenosis leads to higher extrapressure jumps and higher blood speeds around the stenosis site. Also, we observe that the size of the stenosis in stenosed vessels does influence the blood flow. A little change on the cross-sectional value makes vast change on the blood flow rate. This simulation helps the people working in the field of physiological fluid dynamics as well as the medical practitioners.

  1. Reference values comparisons between DMD and C57B whole blood mice using neutron activation analysis

    Energy Technology Data Exchange (ETDEWEB)

    Metairon, Sabrina; Zamboni, Cibele Bugno; Suzuki, Miriam F. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Sant' Anna, Oswaldo A. [Instituto Butantan, Sao Paulo, SP (Brazil); Carvalho, Maria Denise F. [Universidade de Sao Paulo (USP), SP (Brazil)

    2010-07-01

    Full text: In health area animal models are used to perform clinical investigations, for example, to test new medicines for medical diagnostic and treatment investigations before to be applied in human being. Currently, the conventional bio chemistries analyses are performed using serum, but when small size animal model is involved the biological material can be scarce restricting its collection. In the last years the NAA has been successfully applied at LEER at IPEN for investigation of several elements in blood of small sized animals, resulting in an efficiency procedure for clinical practice. The advantage in using whole blood is relate to the fact that this nuclear procedure needs small quantity of biological material (10 to 100 ?L of whole blood ) when compared with the conventional analyses (0.5 to 1.0 ml of serum). But, to use whole blood to perform these biochemistry investigations it is essential to establish the reference value in blood for the species or animal models. In this study we intend to evaluate a normal range of Br, Ca, Cl, K, Mg and Na concentrations in whole blood using NAA in samples of DMDmdx and C57B/6J mice model used for muscular dystrophy investigations. Thirty whole blood samples were analyzed in the IEA R1- nuclear reactor at IPEN (Sao Paulo, Brazil). These data contribute for applications in veterinary medicine related to biochemistry analyses using whole blood. (author)

  2. Optical analysis of middle-molecular mass molecules of blood of individuals suffering from myocardial ischemia

    Directory of Open Access Journals (Sweden)

    V.Korobov

    2002-03-01

    Full Text Available The normalized absorbtion and excitation luminescence spectra of middle mass molecules (MMM obtained from the blood of individuals suffering from myocardial ischemia, show significant changes in the microenvironment of tryptophan fragments in the composition of peptide components in comparison to the spectra of MMM obtained from the blood of healthy individuals.

  3. Gas monitoring data anomaly identification based on spatio-temporal correlativity analysis

    Institute of Scientific and Technical Information of China (English)

    Shi-song ZHU; Yun-jia WANG; Lian-jiang WEI

    2013-01-01

    Based on spatio-temporal correlativity analysis method,the automatic identification techniques for data anomaly monitoring of coal mining working face gas are presented.The asynchronous correlative characteristics of gas migration in working face airflow direction are qualitatively analyzed.The calculation method of asynchronous correlation delay step and the prediction and inversion formulas of gas concentration changing with time and space after gas emission in the air return roadway are provided.By calculating one hundred and fifty groups of gas sensors data series from a coal mine which have the theoretical correlativity,the correlative coefficient values range of eight kinds of data anomaly is obtained.Then the gas monitoring data anomaly identification algorithm based on spatio-temporal correlativity analysis is accordingly presented.In order to improve the efficiency of analysis,the gas sensors code rules which can express the spatial topological relations are suggested.The experiments indicate that methods presented in this article can effectively compensate the defects of methods based on a single gas sensor monitoring data.

  4. Isotope dilution analysis for the determination of zinc in blood samples of diabetic patients

    International Nuclear Information System (INIS)

    Isotope dilution analysis (IDA) based on solvent extraction has been developed for the determination of zinc in the blood of diabetic patients and healthy adults as controls. The method using 65Zn as a tracer is based on the formation of a red colored complex with dithizone in chloroform which is measured by counting of the 1115 keV γ-rays by gamma-ray spectrometry. Various extraction parameters such as pH, nature of solvent and amount of reagent were optimized. Zinc concentration in diabetic patients (n = 10) was found in a much wider range (1.5-157 μg/ml) compared to those in healthy adults (3.1-95.9 μg/ml for n = 5). t-Test of data shows 80-90% confidence limits. A comparison of mean values, 28.5 ± 48.5 μg/ml for diabetics and 33.1 ± 34.5 μg/ml for controls shows 13.9% lower zinc concentration in diabetics. No correlation was found with eating (vegetarian/nonvegetarian)/drinking or smoking habits, but in general, females showed somewhat lower concentration compared to those in males though population size in each case was very small. (author)

  5. Pre-donation deferral of blood donors in South Indian set-up: An analysis

    Directory of Open Access Journals (Sweden)

    Sundar P

    2010-01-01

    Full Text Available Background: It is well known that quite a large number of apparently healthy donors are not able to donate blood successfully because of varied reasons. Aim: We want to analyze the rate and various reasons for deferrals. Materials and Methods: A retrospective analysis of records of the donors, for 3 years, from January 2005 to December 2007 was done, in order to find out the rate and causes of deferral in four categories of age groups, both in male and female, in our Transfusion Medicine Centre, Bangalore, India. Result: There were 16,706 donors, of which 976 donors were deferred (5.84% for various reasons. Of the 16,706 donors registered for donation, females constituted only 11.27%. And deferral rate was about five times more for female (19.85% compared to male (4.06%. The three most common reasons for deferral in female were low hemoglobin levels, low body weight, and hypotension. The deferral rate was higher in the age group of 18-25 years and most common cause was low hemoglobin level. In male, the three most common reasons for deferral were hypertension, under weight, and low hemoglobin levels. The deferral rate varied from 4 to 15% as reported in the literature. The most common cause of deferral in our study and in several studies available in the literature is the same.

  6. Regional cerebral blood flow analysis of vascular dementia by the 133Xe inhalation method

    International Nuclear Information System (INIS)

    Eighty-one cases of ischemic cerebrovascular disease were investigated using the 133Xe inhalation method. Fifty-six were male and 25 were female. ages ranged from 25 to 84, with a mean age of 65.4 years. Thirty-two had cerebrovascular dementia and 49 had non dementia infarction. Two criteria were used for a diagnosis of cerebrovascular dementia: 1) the presense of cerebrovascular disease and 2) a score of less than 21.5 Hasegawa's dementia scale. By computed tomographic findings all cases were classified into three groups: lesion on a right hemisphere, a left hemisphere and bilateral hemispheres. Regional cerebral blood flow (rCBF) was calculated by 2-compartmental analysis and initial slope index method. The results are as follows: 1) Cases of cerebrovascular dementia tended to have a lower mean rCBF value. (p < 0.001). 2)rCBF patterns showed lower values in the central area for cases of laterality as determined by CT scan. 3) Both interhemispheric mean rCBF and mean rCBF classified from main lesion were no significant different between dementia group and non dementia group. 4) A comparison of mean rCBF with Hasegawa's dementia scale revealed a statistically significant correlation. (p < 0.001). (author)

  7. Regional cerebral blood flow analysis of vascular dementia by the single photon emission computed tomography

    International Nuclear Information System (INIS)

    In order to evaluate the relationship between the regional cerebral blood flow (CBF) and cerebrovascular dementia, eleven patients with vascular dementia and eight patients with non-demented infarction were studied and regional CBF were measured quantitatively with single photon emission computed tomography (SPECT) by using N-isopropyl-p-(I-123) iodoamphetamine. All cases were basal infarction and vascular dementia were diagnosed by less than 21.5 of the Hasegawa's dementia score and more than 7 of Hachinsk's ischemic score. The results of the present study were as follows: (1) Cerebrovascular dementia showed lower mean CBF value compared with non-demented group. (2) Regional CBF of bilateral frontal areas and affected basal ganglia were significantly reduced than occipital area in the dementia group. (3) A comparison of regional CBF and the Hasegawa's dementia score revealed a statistically significant correlation at the bilateral frontal areas in the dementia group. It is possible that measuring the regional CBF quantitatively by IMP-SPECT is useful for clinical analysis of vascular dementia. (author)

  8. Finite element analysis of magnetohydrodynamic effects on blood flow in an aneurysmal geometry

    Science.gov (United States)

    Raptis, Anastasios; Xenos, Michalis; Tzirtzilakis, Efstratios; Matsagkas, Miltiadis

    2014-10-01

    Blood flow in an aneurysmal geometry, subjected to a static and uniform magnetic field, was studied. Blood was considered as a Newtonian, incompressible, and electrically conducting fluid. The nonlinear system of partial differential equations, describing the blood flow under the presence of a magnetic field, was discretized by the Galerkin weighted residual method. The transformation in generalized curvilinear coordinates facilitates the solution of the governing equations within arbitrary geometries. Pressure and velocity fields along with wall shear stress distributions were obtained for varying magnetic field intensities and directions. The visualization of the blood streamlines in the dilatation region highlights the effect of a magnetic field on the recirculation zones. The application of static magnetic fields can yield spatio-temporal description of blood flow patterns. The current study discusses implications of the hemodynamic properties estimated by respective screening techniques since the static magnetic field might cause alterations that possibly cannot be detected and thus eliminated.

  9. A Meta-Analysis of Blood Glucose Effects on Human Decision Making

    DEFF Research Database (Denmark)

    Orquin, Jacob Lund; Kurzban, Robert

    2016-01-01

    identified 42 studies relating to 4 dimensions of decision making: willingness to pay, willingness to work, time discounting, and decision style. We did not find a uniform influence of blood glucose on decision making. Instead, we found that low levels of blood glucose increase the willingness to pay and...... willingness to work when a situation is food related, but decrease willingness to pay and work in all other situations. Low levels of blood glucose increase the future discount rate for food; that is, decision makers become more impatient, and to a lesser extent increase the future discount rate for money....... Low levels of blood glucose also increase the tendency to make more intuitive rather than deliberate decisions. However, this effect was only observed in situations unrelated to food. We conclude that blood glucose has domain-specific effects, influencing decision making differently depending on the...

  10. Effect of preoperative autologous blood donation on patients undergoing bimaxillary orthognathic surgery: a retrospective analysis.

    Science.gov (United States)

    Oh, A Y; Seo, K S; Lee, G E; Kim, H J

    2016-04-01

    The efficacy of preoperative autologous blood donation (PABD) was evaluated according to preoperative haemoglobin (Hb) values. The records of 295 patients who underwent bimaxillary orthognathic surgery between July 2007 and August 2008 were reviewed. The records for autologous blood donation, intraoperative transfusion, and related laboratory studies were also evaluated. The transfusion trigger used during this period was Hb blood transfusion was significantly lower in the PABD group than in the no PABD group (15.9% vs. 29.2%, P=0.007). This difference was greater in patients with a preoperative Hb blood transfusion in patients undergoing bimaxillary orthognathic surgery, particularly in patients with a preoperative Hb blood transfusion in these patients. PMID:26678802

  11. Growth and Remodeling in Blood Vessels Studied In Vivo With Fractal Analysis

    Science.gov (United States)

    Parsons-Wingerter, Patricia A.

    2003-01-01

    Every cell in the human body must reside in close proximity to a blood vessel (within approximately 200 mm) because blood vessels provide the oxygen, metabolite, and fluid exchanges required for cellular existence. The growth and remodeling of blood vessels are required to support the normal physiology of embryonic development, reproductive biology, wound healing and adaptive remodeling to exercise, as well as abnormal tissue change in diseases such as cancer, diabetes, and coronary heart disease. Cardiovascular and hemodynamic (blood flow dynamics) alterations experienced by astronauts during long-term spaceflight, including orthostatic intolerance, fluid shifts in the body, and reduced numbers of red (erythrocyte) and white (immune) blood cells, are identified as risk factors of very high priority in the NASA task force report on risk reduction for human spaceflight, the "Critical Path Roadmap."

  12. Analysis on Service Life of Hot-end Components of Gas Turbine Using Equivalent Operation

    Directory of Open Access Journals (Sweden)

    Taixing Wang

    2013-01-01

    Full Text Available The reliability of the gas turbine depends on the technical status and the maintenance level of the hot-end components in a large part.The three main factors influencing on the service life of the hot-end components of the gas turbine were analyzed first.On this basis,various common service life assessment methods for gas turbine were discussed in detail.Aiming at the features of the M701F gas-steam combined cycle unit in Huizhou LNG power plant,a gas turbine life assessment method based on equivalent operation time analysis was put forward.The calculation result of an example shows that the equivalent operation time analysis method is a simple and practical assessment method.

  13. [Study of infrared spectroscopy quantitative analysis method for methane gas based on data mining].

    Science.gov (United States)

    Zhang, Ai-Ju

    2013-10-01

    Monitoring of methane gas is one of the important factors affecting the coal mine safety. The online real-time monitoring of the methane gas is used for the mine safety protection. To improve the accuracy of model analysis, in the present paper, the author uses the technology of infrared spectroscopy to study the gas infrared quantitative analysis algorithm. By data mining technology application in multi-component infrared spectroscopy quantitative analysis algorithm, it was found that cluster analysis partial least squares algorithm is obviously superior to simply using partial least squares algorithm in terms of accuracy. In addition, to reduce the influence of the error on the accuracy of model individual calibration samples, the clustering analysis was used for the data preprocessing, and such denoising method was found to improve the analysis accuracy. PMID:24409709

  14. Patent analysis to identify shale gas development in China and the United States

    International Nuclear Information System (INIS)

    Shale gas has become an increasingly important form of hydrocarbon energy, and related technologies reflect the geographical characteristics of the countries where the gas is extracted and stored. The United States (U.S.) produces most of the world’s shale gas, while China has the world’s largest shale gas reserves. In this research, we focused on identifying the trends in shale-gas related technologies registered to the United States Patent and Trademark Office (USPTO) and to the State Intellectual Property Office of the People’s Republic of China (SIPO) respectively. To cluster shale-gas related technologies, we text-mined the abstracts of patent specifications. It was found that in the U.S., the key advanced technologies were related to hydraulic fracturing, horizontal drilling, and slick water areas, whereas China had a focus on proppants. The results of our study are expected to assist energy experts in designing energy policies related to technology importation. - Highlights: • We analyzed shale gas-related patent applications in the USPTO and SIPO. • We clustered shale gas patents by text mining patent abstract. • Differences were observed in shale gas technologies developed in the U.S. and China. • We proposed the policies of shale gas exploration and development based on patent analysis

  15. Development of a natural gas systems analysis model (GSAM). Annual report, July 1994--June 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-01

    North American natural gas markets have changed dramatically over the past decade. A competitive, cost-conscious production, transportation, and distribution system has emerged from the highly regulated transportation wellhead pricing structure of the 1980`s. Technology advances have played an important role in the evolution of the gas industry, a role likely to expand substantially as alternative fuel price competition and a maturing natural gas resource base force operators to maximize efficiency. Finally, significant changes continue in regional gas demand patterns, industry practices, and infrastructure needs. As the complexity of the gas system grows so does the need to evaluate and plan for alternative future resource, technology, and market scenarios. Traditional gas modeling systems focused solely on the econometric aspects of gas marketing. These systems, developed to assess a regulated industry at a high level of aggregation, rely on simple representation of complex and evolving systems, thereby precluding insight into how the industry will change over time. Credible evaluations of specific policy initiatives and research activities require a different approach. Also, the mounting pressure on energy producers from environmental compliance activities requires development of analysis that incorporates relevant geologic, engineering, and project economic details. The objective of policy, research and development (R&D), and market analysis is to integrate fundamental understanding of natural gas resources, technology, and markets to fully describe the potential of the gas resource under alternative future scenarios. This report summarizes work over the past twelve months on DOE Contract DE-AC21-92MC28138, Development of a Natural Gas Systems Analysis Model (GSAM). The products developed under this project directly support the Morgantown Energy Technology Center (METC) in carrying out its natural gas R&D mission.

  16. Feasibility of finding malignant diseases with the Ar + 501.7 nm laser line using a new blood-analysis method

    Science.gov (United States)

    Sato, H.; Hayashi, H.; Totsuka, T.; Sugiyama, M.; Tsuchiya, S.; Takeuchi, K.; Mochida, N.

    1983-12-01

    Utilizing a new blood-analysis method which uses the interaction between an Ar + laser beam and a blood sample, it can be shown that there is a significant difference in the reflectance variation δ R between the malignant and benign blood, at 501.7 nm of the Ar + laser, under a dc magnetic field, for both human and mouse blood. For the malignant mouse-blood with leukaemia, δ R tends to be positive with the magnetic field, while for the benign blood it is negative. This is also true for the human blood. This fact is confirmed by the inverted variation of the higher order Fourier pattern obtained by the Fourier pattern analyser from the transmitted beam through the diluted sample, for the malignant and benign mouse-blood under the magnetic field.

  17. Multicomponent blood lipid analysis by means of near infrared spectroscopy, in geese.

    Science.gov (United States)

    Bazar, George; Eles, Viktoria; Kovacs, Zoltan; Romvari, Robert; Szabo, Andras

    2016-08-01

    This study provides accurate near infrared (NIR) spectroscopic models on some laboratory determined clinicochemical parameters (i.e. total lipid (5.57±1.95 g/l), triglyceride (2.59±1.36 mmol/l), total cholesterol (3.81±0.68 mmol/l), high density lipoprotein (HDL) cholesterol (2.45±0.58 mmol/l)) of blood serum samples of fattened geese. To increase the performance of multivariate chemometrics, samples significantly deviating from the regression models implying laboratory error were excluded from the final calibration datasets. Reference data of excluded samples having outlier spectra in principal component analysis were not marked as false. Samples deviating from the regression models but having non outlier spectra in PCA were identified as having false reference constituent values. Based on the NIR selection methods, 5% of the reference measurement data were rated as doubtful. The achieved models reached R(2) of 0.864, 0.966, 0.850, 0.793, and RMSE of 0.639 g/l, 0.232 mmol/l, 0.210 mmol/l, 0.241 mmol/l for total lipid, triglyceride, total cholesterol and HDL cholesterol, respectively, during independent validation. Classical analytical techniques focus on single constituents and often require chemicals, time-consuming measurements, and experienced technicians. NIR technique provides a quick, cost effective, non-hazardous alternative method for analysis of several constituents based on one single spectrum of each sample, and it also offers the possibility for looking at the laboratory reference data critically. Evaluation of reference data to identify and exclude falsely analyzed samples can provide warning feedback to the reference laboratory, especially in the case of analyses where laboratory methods are not perfectly suited to the subjected material and there is an increased chance of laboratory error. PMID:27216674

  18. Cerebral blood flow SPET in transient global amnesia with automated ROI analysis by 3DSRT

    Energy Technology Data Exchange (ETDEWEB)

    Takeuchi, Ryo [Division of Nuclear Medicine, Nishi-Kobe Medical Center, Kohjidai 5-7-1, 651-2273, Nishi-ku, Kobe-City, Hyogo (Japan); Matsuda, Hiroshi [Department of Radiology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo (Japan); Yoshioka, Katsunori [Daiichi Radioisotope Laboratories, Ltd., Tokyo (Japan); Yonekura, Yoshiharu [Biomedical Imaging Research Center, University of Fukui, Fukui (Japan)

    2004-04-01

    The aim of this study was to determine the areas involved in episodes of transient global amnesia (TGA) by calculation of cerebral blood flow (CBF) using 3DSRT, fully automated ROI analysis software which we recently developed. Technetium-99m l,l-ethyl cysteinate dimer single-photon emission tomography ({sup 99m}Tc-ECD SPET) was performed during and after TGA attacks on eight patients (four men and four women; mean study interval, 34 days). The SPET images were anatomically standardized using SPM99 followed by quantification of 318 constant ROIs, grouped into 12 segments (callosomarginal, precentral, central, parietal, angular, temporal, posterior cerebral, pericallosal, lenticular nucleus, thalamus, hippocampus and cerebellum), in each hemisphere to calculate segmental CBF (sCBF) as the area-weighted mean value for each of the respective 12 segments based on the regional CBF in each ROI. Correlation of the intra- and post-episodic sCBF of each of the 12 segments of the eight patients was estimated by scatter-plot graphical analysis and Pearson's correlation test with Fisher's Z-transformation. For the control, {sup 99m}Tc-ECD SPET was performed on eight subjects (three men and five women) and repeated within 1 month; the correlation between the first and second sCBF values of each of the 12 segments was evaluated in the same way as for patients with TGA. Excellent reproducibility between the two sCBF values was found in all 12 segments of the control subjects. However, a significant correlation between intra- and post-episodic sCBF was not shown in the thalamus or angular segments of TGA patients. The present study was preliminary, but at least suggested that thalamus and angular regions are closely involved in the symptoms of TGA. (orig.)

  19. Cerebral blood flow SPET in transient global amnesia with automated ROI analysis by 3DSRT

    International Nuclear Information System (INIS)

    The aim of this study was to determine the areas involved in episodes of transient global amnesia (TGA) by calculation of cerebral blood flow (CBF) using 3DSRT, fully automated ROI analysis software which we recently developed. Technetium-99m l,l-ethyl cysteinate dimer single-photon emission tomography (99mTc-ECD SPET) was performed during and after TGA attacks on eight patients (four men and four women; mean study interval, 34 days). The SPET images were anatomically standardized using SPM99 followed by quantification of 318 constant ROIs, grouped into 12 segments (callosomarginal, precentral, central, parietal, angular, temporal, posterior cerebral, pericallosal, lenticular nucleus, thalamus, hippocampus and cerebellum), in each hemisphere to calculate segmental CBF (sCBF) as the area-weighted mean value for each of the respective 12 segments based on the regional CBF in each ROI. Correlation of the intra- and post-episodic sCBF of each of the 12 segments of the eight patients was estimated by scatter-plot graphical analysis and Pearson's correlation test with Fisher's Z-transformation. For the control, 99mTc-ECD SPET was performed on eight subjects (three men and five women) and repeated within 1 month; the correlation between the first and second sCBF values of each of the 12 segments was evaluated in the same way as for patients with TGA. Excellent reproducibility between the two sCBF values was found in all 12 segments of the control subjects. However, a significant correlation between intra- and post-episodic sCBF was not shown in the thalamus or angular segments of TGA patients. The present study was preliminary, but at least suggested that thalamus and angular regions are closely involved in the symptoms of TGA. (orig.)

  20. An analysis of main factors in electron beam flue gas purification

    International Nuclear Information System (INIS)

    Electron beam flue gas purification method is developing very quickly in recent years. Based on the experiment setting for electron beam flue gas purification in Institute of Nuclear Energy and Technology, Tsinghua University, how the technique factors affect the ratio of desulphurization and denitrogenation are described. Radiation dose (D), temperature (T), humidity (H), pour ammonia quantity (α) and initial concentration of SO2 (CSO2) and NOx (CNOx ) are main factors influencing flue gas purification. Using the methods of correlation analysis and regression analysis, the primary effect factors are found out and the regression equations are set to optimize the system process, predigest the system structure and to forecast the experimental results. (authors)