WorldWideScience

Sample records for block signal systems

  1. 49 CFR 236.504 - Operation interconnected with automatic block-signal system.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Operation interconnected with automatic block... Operation interconnected with automatic block-signal system. (a) A continuous inductive automatic train stop... be so interconnected with the signal system as to perform its intended function in event of...

  2. Peak Power Demand and Energy Consumption Reduction Strategies for Trains under Moving Block Signalling System

    OpenAIRE

    Qing Gu; Tao Tang; Fang Cao; Hamid Reza Karimi; Yongduan Song

    2013-01-01

    In the moving block signalling (MBS) system where the tracking target point of the following train is moving forward with its leading train, overload of the substations occurs when a dense queue of trains starts (or restarts) in very close distance interval. This is the peak power demand problem. Several methods have been attempted in the literature to deal with this problem through changing train's operation strategies. However, most existing approaches reduce the service quality. In this pa...

  3. Signal-Conditioning Block of a 1 × 200 CMOS Detector Array for a Terahertz Real-Time Imaging System

    Directory of Open Access Journals (Sweden)

    Jong-Ryul Yang

    2016-03-01

    Full Text Available A signal conditioning block of a 1 × 200 Complementary Metal-Oxide-Semiconductor (CMOS detector array is proposed to be employed with a real-time 0.2 THz imaging system for inspecting large areas. The plasmonic CMOS detector array whose pixel size including an integrated antenna is comparable to the wavelength of the THz wave for the imaging system, inevitably carries wide pixel-to-pixel variation. To make the variant outputs from the array uniform, the proposed signal conditioning block calibrates the responsivity of each pixel by controlling the gate bias of each detector and the voltage gain of the lock-in amplifiers in the block. The gate bias of each detector is modulated to 1 MHz to improve the signal-to-noise ratio of the imaging system via the electrical modulation by the conditioning block. In addition, direct current (DC offsets of the detectors in the array are cancelled by initializing the output voltage level from the block. Real-time imaging using the proposed signal conditioning block is demonstrated by obtaining images at the rate of 19.2 frame-per-sec of an object moving on the conveyor belt with a scan width of 20 cm and a scan speed of 25 cm/s.

  4. Signal-Conditioning Block of a 1 × 200 CMOS Detector Array for a Terahertz Real-Time Imaging System.

    Science.gov (United States)

    Yang, Jong-Ryul; Lee, Woo-Jae; Han, Seong-Tae

    2016-01-01

    A signal conditioning block of a 1 × 200 Complementary Metal-Oxide-Semiconductor (CMOS) detector array is proposed to be employed with a real-time 0.2 THz imaging system for inspecting large areas. The plasmonic CMOS detector array whose pixel size including an integrated antenna is comparable to the wavelength of the THz wave for the imaging system, inevitably carries wide pixel-to-pixel variation. To make the variant outputs from the array uniform, the proposed signal conditioning block calibrates the responsivity of each pixel by controlling the gate bias of each detector and the voltage gain of the lock-in amplifiers in the block. The gate bias of each detector is modulated to 1 MHz to improve the signal-to-noise ratio of the imaging system via the electrical modulation by the conditioning block. In addition, direct current (DC) offsets of the detectors in the array are cancelled by initializing the output voltage level from the block. Real-time imaging using the proposed signal conditioning block is demonstrated by obtaining images at the rate of 19.2 frame-per-sec of an object moving on the conveyor belt with a scan width of 20 cm and a scan speed of 25 cm/s. PMID:26950128

  5. Signal-Conditioning Block of a 1 × 200 CMOS Detector Array for a Terahertz Real-Time Imaging System

    OpenAIRE

    Jong-Ryul Yang; Woo-Jae Lee; Seong-Tae Han

    2016-01-01

    A signal conditioning block of a 1 × 200 Complementary Metal-Oxide-Semiconductor (CMOS) detector array is proposed to be employed with a real-time 0.2 THz imaging system for inspecting large areas. The plasmonic CMOS detector array whose pixel size including an integrated antenna is comparable to the wavelength of the THz wave for the imaging system, inevitably carries wide pixel-to-pixel variation. To make the variant outputs from the array uniform, the proposed signal conditioning block cal...

  6. Nymble Blocking System

    Directory of Open Access Journals (Sweden)

    Anand Joshi

    2012-05-01

    Full Text Available In order to allow users to access Internet services privately, anonymizing networks like Tor uses a series of routers to hide the client’s IP address from the server. These networks, however, have been marred by users employing this anonymity for abusive purposes such as defacing popular web sites. Usually, web site administrators rely on IP-address blocking in order to disable access to misbehaving users, but it is impractical if the abuser routes through an anonymizing network. In order to avoid this, administrators bar all known exit nodes of the anonymizing network, thereby denying anonymous access to all the users(whether misbehaving or not. To solve this issue, we introduce Nymble, a system where servers blacklist misbehaving users, thereby blocking users without affecting their anonymity. Nymble is thus agnostic to varied definitions of misbehavior. Servers can block users for any reason, and the privacy of blacklisted users is not affected in any case.

  7. Biomedical signals and systems

    CERN Document Server

    Tranquillo, Joseph V

    2013-01-01

    Biomedical Signals and Systems is meant to accompany a one-semester undergraduate signals and systems course. It may also serve as a quick-start for graduate students or faculty interested in how signals and systems techniques can be applied to living systems. The biological nature of the examples allows for systems thinking to be applied to electrical, mechanical, fluid, chemical, thermal and even optical systems. Each chapter focuses on a topic from classic signals and systems theory: System block diagrams, mathematical models, transforms, stability, feedback, system response, control, time

  8. Macrocell Builder: IP-Block-Based Design Environment for High-Throughput VLSI Dedicated Digital Signal Processing Systems

    Directory of Open Access Journals (Sweden)

    Urard Pascal

    2006-01-01

    Full Text Available We propose an efficient IP-block-based design environment for high-throughput VLSI systems. The flow generates SystemC register-transfer-level (RTL architecture, starting from a Matlab functional model described as a netlist of functional IP. The refinement model inserts automatically control structures to manage delays induced by the use of RTL IPs. It also inserts a control structure to coordinate the execution of parallel clocked IP. The delays may be managed by registers or by counters included in the control structure. The flow has been used successfully in three real-world DSP systems. The experimentations show that the approach can produce efficient RTL architecture and allows to save huge amount of time.

  9. Support agnostic Bayesian matching pursuit for block sparse signals

    KAUST Repository

    Masood, Mudassir

    2013-05-01

    A fast matching pursuit method using a Bayesian approach is introduced for block-sparse signal recovery. This method performs Bayesian estimates of block-sparse signals even when the distribution of active blocks is non-Gaussian or unknown. It is agnostic to the distribution of active blocks in the signal and utilizes a priori statistics of additive noise and the sparsity rate of the signal, which are shown to be easily estimated from data and no user intervention is required. The method requires a priori knowledge of block partition and utilizes a greedy approach and order-recursive updates of its metrics to find the most dominant sparse supports to determine the approximate minimum mean square error (MMSE) estimate of the block-sparse signal. Simulation results demonstrate the power and robustness of our proposed estimator. © 2013 IEEE.

  10. VLSI mixed signal processing system

    Science.gov (United States)

    Alvarez, A.; Premkumar, A. B.

    1993-01-01

    An economical and efficient VLSI implementation of a mixed signal processing system (MSP) is presented in this paper. The MSP concept is investigated and the functional blocks of the proposed MSP are described. The requirements of each of the blocks are discussed in detail. A sample application using active acoustic cancellation technique is described to demonstrate the power of the MSP approach.

  11. Block diagonal and schur complement preconditioners for block-toeplitz systems with small size blocks

    OpenAIRE

    Ching, WK; Ng, MK; Wen, YW

    2007-01-01

    In this paper we consider the solution of Hermitian positive definite block-Toeplitz systems with small size blocks. We propose and study block diagonal and Schur complement preconditioners for such block-Toeplitz matrices. We show that for some block-Toeplitz matrices, the spectra of the preconditioned matrices are uniformly bounded except for a fixed number of outliers where this fixed number depends only on the size of the block. Hence, conjugate gradient type methods, when applied to solv...

  12. A Signal Coordination Control Based on Traversing Empty between Mid-Block Street Crossing and Intersection

    Directory of Open Access Journals (Sweden)

    Changjiang Zheng

    2012-01-01

    Full Text Available To solve the problem in pedestrian Mid-Block street crossing, the method of signal coordination control between mid-block street crossing and intersection is researched in this paper. The paper proposes to use “distance-flow rate-time” graph as the tool for building coordination control system model which is for different situations of traffic control. Through alternating the linear optimization model, the system outputs the distribution of signal timing and system operational factors (delays in vehicles and mid-block street crossing. Finally, taking one section on the Taiping North Road in Nanjing as an example, the signal coordination control is carried out. And the results which are delays in the vehicles and mid-block street crossing are compared to those in the current distribution of signal timing.

  13. Landscape block of geoinformation system

    International Nuclear Information System (INIS)

    Expirience of constructing landscape block of geoinformation system, designated for regional geoecological forecasting on the basis of mega-line-Delta computer is presented. Works were conducted in summer of 1986 for the purpose of forecasting radionuclide migration in 30-km zone of the Chernobyl accident, as well as evaluation of radioecological situation in Kiev, Zhitomir and Chernigov regions. System design work lies in choice and construction of information model of the natural medium, reflected and processed in data bank by methods of information science. Three groups were distinguished in examined region according to intensity of substance migration: 1) zones of preferred evacuation with surface run-off, 2) transit zones, 3) zones of evacuation and accumulation of flood plain substance

  14. Curcumin blocks interleukin-1 signaling in chondrosarcoma cells.

    Directory of Open Access Journals (Sweden)

    Thomas Kalinski

    Full Text Available Interleukin (IL-1 signaling plays an important role in inflammatory processes, but also in malignant processes. The essential downstream event in IL-1 signaling is the activation of nuclear factor (NF-κB, which leads to the expression of several genes that are involved in cell proliferation, invasion, angiogenesis and metastasis, among them VEGF-A. As microenvironment-derived IL-1β is required for invasion and angiogenesis in malignant tumors, also in chondrosarcomas, we investigated IL-1β-induced signal transduction and VEGF-A expression in C3842 and SW1353 chondrosarcoma cells. We additionally performed in vitro angiogenesis assays and NF-κB-related gene expression analyses. Curcumin is a substance which inhibits IL-1 signaling very early by preventing the recruitment of IL-1 receptor associated kinase (IRAK to the IL-1 receptor. We demonstrate that IL-1 signaling and VEGF-A expression are blocked by Curcumin in chondrosarcoma cells. We further show that Curcumin blocks IL-1β-induced angiogenesis and NF-κB-related gene expression. We suppose that IL-1 blockade is an additional treatment option in chondrosarcoma, either by Curcumin, its derivatives or other IL-1 blocking agents.

  15. Building blocks for embedded control systems

    NARCIS (Netherlands)

    Broenink, Jan F.; Hilderink, Gerald H.; Bakkers, André W.P.; Veen, Jean Pierre

    2000-01-01

    Developing embedded control systems using a building-block approach at all the parts enables an efficient and fast design process. Main reasons are the real plug-and-play capabilities of the blocks. Furthermore, due the simulatability of the designs, parts of the system can already be tested before

  16. Block methods for linear Hamiltonian systems

    OpenAIRE

    Tian, Hongjiong; Chen, Bailin

    2014-01-01

    For the numerical treatment of Hamiltonian differential equations,symplectic integrators are regarded as the most suitable choice.In this paper we are concerned with the applicability of block methods for the discrete approximate solution of linear Hamiltonian systems.The k-dimensional block methods are convergent of order at least k+1 for ordinary differential equations.We provide conditions on the coefficients of the equivalent block methods in order to maintain two important properties of...

  17. Building blocks for embedded control systems

    OpenAIRE

    Broenink, Jan F.; Hilderink, Gerald H.; Bakkers, André W.P.; Veen, Jean Pierre

    2000-01-01

    Developing embedded control systems using a building-block approach at all the parts enables an efficient and fast design process. Main reasons are the real plug-and-play capabilities of the blocks. Furthermore, due the simulatability of the designs, parts of the system can already be tested before the other parts are available. We have applied an object-oriented approach for modeling all three parts of embedded control systems: compositional programming for the embedded software parts; VHDL ...

  18. Combined parametric-nonparametric identification of block-oriented systems

    CERN Document Server

    Mzyk, Grzegorz

    2014-01-01

    This book considers a problem of block-oriented nonlinear dynamic system identification in the presence of random disturbances. This class of systems includes various interconnections of linear dynamic blocks and static nonlinear elements, e.g., Hammerstein system, Wiener system, Wiener-Hammerstein ("sandwich") system and additive NARMAX systems with feedback. Interconnecting signals are not accessible for measurement. The combined parametric-nonparametric algorithms, proposed in the book, can be selected dependently on the prior knowledge of the system and signals. Most of them are based on the decomposition of the complex system identification task into simpler local sub-problems by using non-parametric (kernel or orthogonal) regression estimation. In the parametric stage, the generalized least squares or the instrumental variables technique is commonly applied to cope with correlated excitations. Limit properties of the algorithms have been shown analytically and illustrated in simple experiments.

  19. Criminal Justice Systems. Block I: Law Enforcement. Block II: The Courts. Block III: Corrections. Block IV: Community Relations. Block V: Proficiency Skills. Block VI: Criminalistics. Instructor Guide.

    Science.gov (United States)

    Florida State Dept. of Education, Tallahassee. Div. of Vocational, Adult, and Community Education.

    This instructor guide together with a student guide comprise a set of curriculum materials on the criminal justice system. The instructor guide is a resource for planning and managing individualized, competency-based instruction in six major subject areas or blocks, which are further broken down into several units with some units having several…

  20. Criminal Justice Systems. Block I: Law Enforcement. Block II: The Courts. Block III: Corrections. Block IV: Community Relations. Block V: Proficiency Skills. Block VI: Criminalistics. Student Guide.

    Science.gov (United States)

    Florida State Dept. of Education, Tallahassee. Div. of Vocational, Adult, and Community Education.

    This student guide together with an instructor guide comprise a set of curriculum materials on the criminal justice system. The student guide contains self-contained instructional material that students can study at their own pace most of the time. Six major subject areas or blocks, which are further broken down into several units, with some units…

  1. System for Gauge Blocks Diagnostics

    Czech Academy of Sciences Publication Activity Database

    Buchta, Zdeněk; Mikel, Břetislav; Čížek, Martin; Lazar, Josef; Číp, Ondřej

    Düsseldorf: VDI Verlag GmbH, 2011, s. 91-96. ISBN 978-3-18-092156-3. ISSN 0083-5560. [IMEKO Symposium - Laser Metrology for Precision Measurement and Inspection in Industry 2011 /10./. Braunschweig (DE), 12.09.2011-14.09.2011] R&D Projects: GA ČR GP102/09/P293; GA ČR GPP102/11/P819; GA ČR GAP102/10/1813; GA MPO 2A-1TP1/127; GA MŠk ED0017/01/01; GA MŠk(CZ) LC06007 Institutional research plan: CEZ:AV0Z20650511 Keywords : gauge blocks calibration * low-coherence interferometry * laser interferometry Subject RIV: BH - Optics, Masers, Lasers

  2. The Signal Distribution System

    CERN Document Server

    Belohrad, D; CERN. Geneva. AB Department

    2005-01-01

    For the purpose of LHC signal observation and high frequency signal distribution, the Signal Distribution System (SDS) was built. The SDS can contain up to 5 switching elements, where each element allows the user to switch between one of the maximum 8 bi-directional signals. The coaxial relays are used to switch the signals. Depending of the coaxial relay type used, the transfer bandwidth can go up to 18GHz. The SDS is controllable via TCP/IP, parallel port, or locally by rotary switch.

  3. Modularity in signaling systems

    International Nuclear Information System (INIS)

    Modularity is a property by which the behavior of a system does not change upon interconnection. It is crucial for understanding the behavior of a complex system from the behavior of the composing subsystems. Whether modularity holds in biology is an intriguing and largely debated question. In this paper, we discuss this question taking a control system theory view and focusing on signaling systems. In particular, we argue that, despite signaling systems being constituted of structural modules, such as covalent modification cycles, modularity does not hold in general. As in any engineering system, impedance-like effects, called retroactivity, appear at interconnections and alter the behavior of connected modules. We further argue that while signaling systems have evolved sophisticated ways to counter-act retroactivity and enforce modularity, retroactivity may also be exploited to finely control the information processing of signaling pathways. Testable predictions and experimental evidence are discussed with their implications. (paper)

  4. Bioelectric Signal Measuring System

    International Nuclear Information System (INIS)

    We describe a low noise measuring system based on interdigitated electrodes for sensing bioelectrical signals. The system registers differential voltage measurements in order of microvolts. The base noise during measurements was in nanovolts and thus, the sensing signals presented a very good signal to noise ratio. An excitation voltage of 1Vrms with 10 KHz frequency was applied to an interdigitated capacitive sensor without a material under test and to a mirror device simultaneously. The output signals of both devices was then subtracted in order to obtain an initial reference value near cero volts and reduce parasitic capacitances due to the electronics, wiring and system hardware as well. The response of the measuring system was characterized by monitoring temporal bioelectrical signals in real time of biological materials such as embryo chicken heart cells and bovine suprarenal gland cells

  5. Quantum Integrable Systems from Conformal Blocks

    CERN Document Server

    Chen, Heng-Yu

    2016-01-01

    In this note, we extend the striking connections between quantum integrable systems and conformal blocks recently found in http://arxiv.org/abs/1602.01858 in several directions. First, we explicitly demonstrate that the action of quartic conformal Casimir operator on general d-dimensional scalar conformal blocks, can be expressed in terms of certain combinations of commuting integrals of motions of the two particle hyperbolic BC2 Calogero-Sutherland system. The permutation and reflection properties of the underlying Dunkl operators play crucial roles in establishing such a connection. Next, we show that the scalar superconformal blocks in SCFTs with four and eight supercharges and suitable chirality constraints can also be identified with the eigenfunctions of the same Calogero-Sutherland system, this demonstrates the universality of such a connection. Finally, we observe that the so-called "seed" conformal blocks for constructing four point functions for operators with arbitrary space-time spins in four dime...

  6. Controlling systems of cogeneration blocks

    International Nuclear Information System (INIS)

    In this article the main parts of cogeneration unit control system are described. Article is aimed on electric power measurement with electricity protection as with temperature system regulation. In conclusion of the article, the control algorithm with perspective of cogeneration solve is indicated. (authors)

  7. Growth-Blocking Peptides As Nutrition-Sensitive Signals for Insulin Secretion and Body Size Regulation

    OpenAIRE

    Koyama, Takashi; Mirth, Christen K.

    2016-01-01

    In Drosophila, the fat body, functionally equivalent to the mammalian liver and adipocytes, plays a central role in regulating systemic growth in response to nutrition. The fat body senses intracellular amino acids through Target of Rapamycin (TOR) signaling, and produces an unidentified humoral factor(s) to regulate insulin-like peptide (ILP) synthesis and/or secretion in the insulin-producing cells. Here, we find that two peptides, Growth-Blocking Peptide (GBP1) and CG11395 (GBP2), are prod...

  8. Building Blocks for Control System Software

    NARCIS (Netherlands)

    Broenink, J.F.; Hilderink, G.H.; Amerongen van, J.; Jonker, B.; Regtien, P.P.L.

    2001-01-01

    Software implementation of control laws for industrial systems seem straightforward, but is not. The computer code stemming from the control laws is mostly not more than 10 to 30% of the total. A building-block approach for embedded control system development is advocated to enable a fast and effici

  9. Continuous signals and systems with Matlab

    CERN Document Server

    ElAli, Taan

    2008-01-01

    Designed for a one-semester undergraduate course in continuous linear systems, Continuous Signals and Systems with MATLAB®, Second Edition presents the tools required to design, analyze, and simulate dynamic systems. It thoroughly describes the process of the linearization of nonlinear systems, using MATLAB® to solve most examples and problems. With updates and revisions throughout, this edition focuses more on state-space methods, block diagrams, and complete analog filter design. New to the Second Edition           A chapter on block diagrams that covers various classical and state-space

  10. Efficient Recovery of Block Sparse Signals via Zero-point Attracting Projection

    OpenAIRE

    Liu, Jingbo; Jin, Jian; Gu, Yuantao

    2012-01-01

    In this paper, we consider compressed sensing (CS) of block-sparse signals, i.e., sparse signals that have nonzero coefficients occurring in clusters. An efficient algorithm, called zero-point attracting projection (ZAP) algorithm, is extended to the scenario of block CS. The block version of ZAP algorithm employs an approximate $l_{2,0}$ norm as the cost function, and finds its minimum in the solution space via iterations. For block sparse signals, an analysis of the stability of the local m...

  11. Efficient Recovery of Block Sparse Signals via Zero-point Attracting Projection

    CERN Document Server

    Liu, Jingbo; Gu, Yuantao

    2012-01-01

    In this paper, we consider compressed sensing (CS) of block-sparse signals, i.e., sparse signals that have nonzero coefficients occurring in clusters. An efficient algorithm, called zero-point attracting projection (ZAP) algorithm, is extended to the scenario of block CS. The block version of ZAP algorithm employs an approximate $l_{2,0}$ norm as the cost function, and finds its minimum in the solution space via iterations. For block sparse signals, an analysis of the stability of the local minimums of this cost function under the perturbation of noise reveals an advantage of the proposed algorithm over its original non-block version in terms of reconstruction error. Finally, numerical experiments show that the proposed algorithm outperforms other state of the art methods for the block sparse problem in various respects, especially the stability under noise.

  12. UV light blocks EGFR signalling in human cancer cell lines

    DEFF Research Database (Denmark)

    Olsen, BB; Neves-Petersen, M T; Klitgaard, S;

    2007-01-01

    antibodies. There was a threshold level, below which the receptor could not be blocked. In addition, illumination caused the cells to upregulate the cyclin-dependent kinase inhibitor p21WAF1, irrespective of the p53 status. Since the EGF receptor is often overexpressed in cancers and other proliferative skin......UV light excites aromatic residues, causing these to disrupt nearby disulphide bridges. The EGF receptor is rich in aromatic residues near the disulphide bridges. Herein we show that laser-pulsed UV illumination of two different skin-derived cancer cell lines i.e. Cal-39 and A431, which both...

  13. Wireless data signal transmission system

    DEFF Research Database (Denmark)

    2014-01-01

    The present invention relates to a method for providing a radio frequency signal for transmission, a system for providing a radio frequency signal for transmission and a method for wireless data transmission between a transmitter and a receiver.......The present invention relates to a method for providing a radio frequency signal for transmission, a system for providing a radio frequency signal for transmission and a method for wireless data transmission between a transmitter and a receiver....

  14. A SIGNALING MODEL OF CONTROL BLOCK SALES BY ENTREPRENEURS

    OpenAIRE

    Lynda S. Livingston

    2007-01-01

    In this paper, we present a model in which higher-valued managers signal their value by voluntarily submitting to shareholder oversight. If a manager is willing to sell enough stock to release voting control, he is perceived to be of higher quality than if he had defensively maintained control. The implication of the model is that voluntary/control sales by insiders can be good news for the firm. This is consistent with the share-price increases that follow the deaths of entrenched managers.

  15. Acoustic Signals and Systems

    DEFF Research Database (Denmark)

    present topics on signal processing which are important in a specific area of acoustics. These will be of interest to specialists in these areas because they will be presented from their technical perspective, rather than a generic engineering approach to signal processing. Non-specialists, or specialists...

  16. Acoustic Signals and Systems

    DEFF Research Database (Denmark)

    The Handbook of Signal Processing in Acoustics will compile the techniques and applications of signal processing as they are used in the many varied areas of Acoustics. The Handbook will emphasize the interdisciplinary nature of signal processing in acoustics. Each Section of the Handbook will...... present topics on signal processing which are important in a specific area of acoustics. These will be of interest to specialists in these areas because they will be presented from their technical perspective, rather than a generic engineering approach to signal processing. Non-specialists, or specialists...... from different areas, will find the self-contained chapters accessible and will be interested in the similarities and differences between the approaches and techniques used in different areas of acoustics....

  17. Growth-Blocking Peptides As Nutrition-Sensitive Signals for Insulin Secretion and Body Size Regulation.

    Science.gov (United States)

    Koyama, Takashi; Mirth, Christen K

    2016-02-01

    In Drosophila, the fat body, functionally equivalent to the mammalian liver and adipocytes, plays a central role in regulating systemic growth in response to nutrition. The fat body senses intracellular amino acids through Target of Rapamycin (TOR) signaling, and produces an unidentified humoral factor(s) to regulate insulin-like peptide (ILP) synthesis and/or secretion in the insulin-producing cells. Here, we find that two peptides, Growth-Blocking Peptide (GBP1) and CG11395 (GBP2), are produced in the fat body in response to amino acids and TOR signaling. Reducing the expression of GBP1 and GBP2 (GBPs) specifically in the fat body results in smaller body size due to reduced growth rate. In addition, we found that GBPs stimulate ILP secretion from the insulin-producing cells, either directly or indirectly, thereby increasing insulin and insulin-like growth factor signaling activity throughout the body. Our findings fill an important gap in our understanding of how the fat body transmits nutritional information to the insulin producing cells to control body size. PMID:26928023

  18. Bipolar analog signal multiplexing for position-sensitive PET block detectors

    International Nuclear Information System (INIS)

    This paper describes a block detector multiplexing technique that simplifies the extension of axial length or ring radius without employing extra data acquisition channels. The proposed multiplexing circuit (bipolar multiplexing) multiplexes block detectors by encoding the position-related signal outputs with different combinations of polarity. Accordingly, it is possible to distinguish the detectors using a shared readout channel. This method was evaluated by assessing one to 16 block detectors using four data acquisition channels and one trigger input at different count rates. The experimental results showed that the multiplexing of block detectors did not significantly degrade timing, energy or spatial performance at low count rates, while reducing the required number of data acquisition channels and wire routing density. On the other hand, the degradation was seen as total count rates of all blocks increased. (paper)

  19. Design and Implementation of Noise Free Audio Speech Signal Using Fast Block Least Mean Square Algorithm

    Directory of Open Access Journals (Sweden)

    J. Jebastine

    2012-06-01

    Full Text Available This paper describes the development of an adaptive noise cancellation algorithm for effective recognition of speech signal and also to improve SNR for an adaptive step size input. An adaptive filter with Fast Block Least Mean square Algorithm is designed for noise free audio (speech/music signals. The signal input used is a audio speech signal which could be in the form of a recorded voice. The filter used is adaptive filter and the algorithm used is Fast Block LMS algorithm. A Gaussian noise is added to this input signal and given as a input to the Fast Block LMS. The algorithm is implemented in Matlab and was tested for noise cancellation in speech signals. A Simulink model is designed which results in a noise free audio speech signal at the output. The FBLMS algorithm is computationally efficient in noise cancellation. The noise level in speech signal can be 1 mild, 2 moderate, 3 severe. The SNR is estimated by varying the adaptive step size.

  20. Design and Implementation of Noise Free Audio Speech Signal Using Fast Block Least Mean Square Algorithm

    Directory of Open Access Journals (Sweden)

    J. Jebastine

    2012-07-01

    Full Text Available This paper describes the development of an adaptive noise cancellation algorithm for effective recognition of speech signal and also to improve SNR for an adaptive step size input. An adaptive filter with Fast Block Least Mean square Algorithm is designed for noise free audio (speech/music signals. The signal input used is a audio speech signal which could be in the form of a recorded voice. The filter used is adaptive filter and the algorithm used is Fast Block LMS algorithm. A Gaussian noise is added to this input signal and given as a input to the Fast Block LMS. The algorithm is implemented in Matlab and was tested fornoise cancellation in speech signals. A Simulink model is designed which results in a noise free audiospeech signal at the output. The FBLMS algorithm is computationally efficient in noise cancellation. The noise level in speech signal can be 1 mild, 2 moderate, 3 severe. The SNR is estimated by varying the adaptive step size.

  1. Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells.

    Directory of Open Access Journals (Sweden)

    Xing Chen

    Full Text Available Signal abnormalities in human cells usually cause unexpected consequences for individual health. We focus on these kinds of events involved in JAK-STAT signal pathways, especially the ones triggered by aberrant activated STAT3, an oncoprotein which participates in essential processes of cell survival, growth and proliferation in many types of tumors, as well as immune diseases. By establishing a STAT3 signal based high-throughput drug screening system in human lung cancer A549 cells, we have screened a library from natural products which contained purified compounds from medicinal herbs. One compound, named Brevilin A, exhibited both strong STAT3 signal inhibition and STAT3 signal dependent cell growth inhibition. Further investigations revealed that Brevilin A not only inhibits STAT3 signaling but also STAT1 signaling for cytokines induced phosphorylation of STAT3 and STAT1 as well as the expression of their target genes. In addition, we found Brevilin A could attenuate the JAKs activity by blocking the JAKs tyrosine kinase domain JH1. The levels of cytokine induced phosphorylation of STATs and other substrates were dramatically reduced by treatment of Brevilin A. The roles of Brevilin A targeting on JAKs activity indicate that Brevilin A may not only be used as a STAT3 inhibitor but also a compound blocking other JAK-STAT hyperactivation. Thus, these findings provided a strong impetus for the development of selective JAK-STAT inhibitors and therapeutic drugs in order to improve survival of patients with hyperactivated JAKs and STATs.

  2. Signals and systems with MATLAB

    CERN Document Server

    Yang, Won Young; Song, Ik H; Cho, Yong S

    2009-01-01

    Covers some of the theoretical foundations and mathematical derivations that can be used in higher-level related subjects such as signal processing, communication, and control, minimizing the mathematical difficulty and computational burden. This book illustrates the usage of MATLAB and Simulink for signal and system analysis and design.

  3. COMPRESSED SPEECH SIGNAL SENSING BASED ON THE STRUCTURED BLOCK SPARSITY WITH PARTIAL KNOWLEDGE OF SUPPORT

    Institute of Scientific and Technical Information of China (English)

    Ji Yunyun; Yang Zhen; Xu Qian

    2012-01-01

    Structural and statistical characteristics of signals can improve the performance of Compressed Sensing (CS).Two kinds of features of Discrete Cosine Transform (DCT) coefficients of voiced speech signals are discussed in this paper.The first one is the block sparsity of DCT coefficients of voiced speech formulated from two different aspects which are the distribution of the DCT coefficients of voiced speech and the comparison of reconstruction performance between the mixed l2 /l1 program and Basis Pursuit (BP).The block sparsity of DCT coefficients of voiced speech means that some algorithms of block-sparse CS can be used to improve the recovery performance of speech signals.It is proved by the simulation results of the l2 / reweighted l1 mixed program which is an improved version of the mixed l2 /l1 program.The second one is the well known large DCT coefficients of voiced speech focus on low frequency.In line with this feature,a special Gaussian and Partial Identity Joint (GPIJ)matrix is constructed as the sensing matrix for voiced speech signals.Simulation results show that the GPIJ matrix outperforms the classical Gaussian matrix for speech signals of male and female adults.

  4. New Preconditioners for Nonsymmetric Saddle Point Systems with Singular Block

    OpenAIRE

    Qingbing Liu

    2013-01-01

    We investigate the solution of large linear systems of saddle point type with singular (1,1) block by preconditioned iterative methods and consider two parameterized block triangular preconditioners used with Krylov subspace methods which have the attractive property of improved eigenvalue clustering with increased ill-conditioning of the (1,1) block of the saddle point matrix, including the choice of the parameter. Meanwhile, we analyze the spectral characteristics of two preconditioners and...

  5. Handbook of signal processing systems

    CERN Document Server

    Deprettere, Ed; Leupers, Rainer; Takala, Jarmo

    2013-01-01

    Handbook of Signal Processing Systems is organized in three parts. The first part motivates representative applications that drive and apply state-of-the art methods for design and implementation of signal processing systems; the second part discusses architectures for implementing these applications; the third part focuses on compilers and simulation tools, describes models of computation and their associated design tools and methodologies. This handbook is an essential tool for professionals in many fields and researchers of all levels.

  6. Solving block linear systems with low-rank off-diagonal blocks is easily parallelizable

    Energy Technology Data Exchange (ETDEWEB)

    Menkov, V. [Indiana Univ., Bloomington, IN (United States)

    1996-12-31

    An easily and efficiently parallelizable direct method is given for solving a block linear system Bx = y, where B = D + Q is the sum of a non-singular block diagonal matrix D and a matrix Q with low-rank blocks. This implicitly defines a new preconditioning method with an operation count close to the cost of calculating a matrix-vector product Qw for some w, plus at most twice the cost of calculating Qw for some w. When implemented on a parallel machine the processor utilization can be as good as that of those operations. Order estimates are given for the general case, and an implementation is compared to block SSOR preconditioning.

  7. Measles virus V protein blocks Jak1-mediated phosphorylation of STAT1 to escape IFN-α/β signaling

    International Nuclear Information System (INIS)

    Viruses have evolved various strategies to escape the antiviral activity of type I interferons (IFN-α/β). For measles virus, this function is carried by the polycistronic gene P that encodes, by an unusual editing strategy, for the phosphoprotein P and the virulence factor V (MV-V). MV-V prevents STAT1 nuclear translocation by either sequestration or phosphorylation inhibition, thereby blocking IFN-α/β pathway. We show that both the N- and C-terminal domains of MV-V (PNT and VCT) contribute to the inhibition of IFN-α/β signaling. Using the two-hybrid system and co-affinity purification experiments, we identified STAT1 and Jak1 as interactors of MV-V and demonstrate that MV-V can block the direct phosphorylation of STAT1 by Jak1. A deleterious mutation within the PNT domain of MV-V (Y110H) impaired its ability to interact and block STAT1 phosphorylation. Thus, MV-V interacts with at least two components of IFN-α/β receptor complex to block downstream signaling

  8. Block Preconditioned SSOR Methods for -Matrices Linear Systems

    OpenAIRE

    Zhao-Nian Pu; Xue-Zhong Wang

    2013-01-01

    We present a block preconditioner and consider block preconditioned SSOR iterative methods for solving linear system $Ax=b$ . When $A$ is an $H$ -matrix, the convergence and some comparison results of the spectral radius for our methods are given. Numerical examples are also given to illustrate that our methods are valid.

  9. Cooling System: Automotive Mechanics Instructional Program. Block 6.

    Science.gov (United States)

    O'Brien, Ralph D.

    The last of six instructional blocks in automotive mechanics, the lessons and supportive information in the document provide a guide for teachers in planning an instructional program in the automotive cooling system at the secondary and post secondary level. The material, as organized, is a suggested sequence of instruction within each block. Each…

  10. Systemic defense signaling in tomato

    Institute of Scientific and Technical Information of China (English)

    LI Changbao; SUN Jiaqiang; JIANG Hongling; WU Xiaoyan; LI Chuanyou

    2005-01-01

    The wound-inducible expression of proteinase inhibitors (PIs) genes in tomato provides a powerful model system to elucidate the signal transduction pathway of sys- temic defense response. An increasing body of evidence indi- cates that systemin and jasmonic acid (JA) work in the same signaling pathway to activate the expression of PIs and other defense-related genes. However, little is known about how systemin and JA interact to regulate cell to cell communica- tion over long distances. Genetic analysis of the systemin/JA signaling pathway in tomato plants provides a unique opportunity to dissect the mechanism by which peptide and oxylipin signals interact to coordinate systemic expression of defense-related genes. Previously, it has been proposed that systemin is the long-distance mobile signal for systemic expression of defense related genes. However, recent genetic approach provided new evidence that jasmonic acid, rather than systemin, functions as the systemic wound signal, and that the peptide systemin works to regulate the biosynthesis of JA.

  11. Block Iterative Reweighted Algorithms for Super-Resolution of Spectrally Sparse Signals

    OpenAIRE

    Cho, Myung; Mishra, Kumar Vijay; Cai, Jian-Feng; Xu, Weiyu

    2015-01-01

    We propose novel algorithms that enhance the performance of recovering unknown continuous-valued frequencies from undersampled signals. Our iterative reweighted frequency recovery algorithms employ the support knowledge gained from earlier steps of our algorithms as block prior information to enhance frequency recovery. Our methods improve the performance of the atomic norm minimization which is a useful heuristic in recovering continuous-valued frequency contents. Numerical results demonstra...

  12. Modular Analysis of Almost Block Diagonal Systems of Equations

    OpenAIRE

    El-Mistikawy, Tarek M. A.

    2013-01-01

    Almost block diagonal linear systems of equations can be exemplified by two modules. This makes it possible to construct all sequential forms of band and/or block elimination methods, six old and fourteen new. It allows easy assessment of the methods on the basis of their operation counts, storage needs, and admissibility of partial pivoting. It unveils a robust partial pivoting strategy- local pivoting. Extension of modular analysis to bordered systems is also included.

  13. New adhesive systems based on functionalized block copolymers

    Energy Technology Data Exchange (ETDEWEB)

    Kent, M.; Saunders, R.; Hurst, M.; Small, J.; Emerson, J.; Zamora, D.

    1997-05-01

    The goal of this work was to evaluate chemically-functionalized block copolymers as adhesion promoters for metal/thermoset resin interfaces. Novel block copolymers were synthesized which contain pendant functional groups reactive toward copper and epoxy resins. In particular, imidazole and triazole functionalities that chelate with copper were incorporated onto one block, while secondary amines were incorporated onto the second block. These copolymers were found to self-assemble from solution onto copper surfaces to form monolayers. The structure of the adsorbed monolayers were studied in detail by neutron reflection and time-of-flight secondary ion mass spectrometry. The monolayer structure was found to vary markedly with the solution conditions and adsorption protocol. Appropriate conditions were found for which the two blocks form separate layers on the surface with the amine functionalized block exposed at the air surface. Adhesion testing of block copolymer-coated copper with epoxy resins was performed in both lap shear and peel modes. Modest enhancements in bond strengths were observed with the block copolymer applied to the native oxide. However, it was discovered that the native oxide is the weak link, and that by simply removing the native oxide, and then applying an epoxy resin before the native oxide can reform, excellent bond strength in the as-prepared state as well as excellent retention of bond strength after exposure to solder in ambient conditions are obtained. It is recommended that long term aging studies be performed with and without the block copolymer. In addition, the functionalized block copolymer method should be evaluated for another system that has inherently poor bonding, such as the nickel/silicone interface, and for systems involving metals and alloys which form oxides very rapidly, such as aluminum and stainless steel, where bonding strategies involve stabilizing the native oxide.

  14. Signal processing and linear systems

    CERN Document Server

    Lathi, B P

    1998-01-01

    This text presents a comprehensive treatment of signal processing and linear systems suitable for juniors and seniors in electrical engineering. Based on B. P. Lathi's widely used book, Linear Systems and Signals, it features additional applications to communications, controls, and filtering as well as new chapters on analog and digital filters and digital signal processing. Lathi emphasizes the physical appreciation of concepts rather than the mere mathematical manipulation of symbols. Avoiding the tendency to treat engineering as a branch of applied mathematics, he uses mathematics to enhance physical and intuitive understanding of concepts, instead of employing it only to prove axiomatic theory. Theoretical results are supported by carefully chosen examples and analogies, allowing students to intuitively discover meaning for themselves.

  15. Morbillivirus v proteins exhibit multiple mechanisms to block type 1 and type 2 interferon signalling pathways.

    Directory of Open Access Journals (Sweden)

    Senthil K Chinnakannan

    Full Text Available Morbilliviruses form a closely related group of pathogenic viruses which encode three non-structural proteins V, W and C in their P gene. Previous studies with rinderpest virus (RPV and measles virus (MeV have demonstrated that these non-structural proteins play a crucial role in blocking type I (IFNα/β and type II (IFNγ interferon action, and various mechanisms have been proposed for these effects. We have directly compared four important morbilliviruses, rinderpest (RPV, measles virus (MeV, peste des petits ruminants virus (PPRV and canine distemper virus (CDV. These viruses and their V proteins could all block type I IFN action. However, the viruses and their V proteins had varying abilities to block type II IFN action. The ability to block type II IFN-induced gene transcription correlated with co-precipitation of STAT1 with the respective V protein, but there was no correlation between co-precipitation of either STAT1 or STAT2 and the abilities of the V proteins to block type I IFN-induced gene transcription or the creation of the antiviral state. Further study revealed that the V proteins of RPV, MeV, PPRV and CDV could all interfere with phosphorylation of the interferon-receptor-associated kinase Tyk2, and the V protein of highly virulent RPV could also block the phosphorylation of another such kinase, Jak1. Co-precipitation studies showed that morbillivirus V proteins all form a complex containing Tyk2 and Jak1. This study highlights the ability of morbillivirus V proteins to target multiple components of the IFN signalling pathways to control both type I and type II IFN action.

  16. Block Sparse Compressed Sensing of Electroencephalogram (EEG) Signals by Exploiting Linear and Non-Linear Dependencies.

    Science.gov (United States)

    Mahrous, Hesham; Ward, Rabab

    2016-01-01

    This paper proposes a compressive sensing (CS) method for multi-channel electroencephalogram (EEG) signals in Wireless Body Area Network (WBAN) applications, where the battery life of sensors is limited. For the single EEG channel case, known as the single measurement vector (SMV) problem, the Block Sparse Bayesian Learning-BO (BSBL-BO) method has been shown to yield good results. This method exploits the block sparsity and the intra-correlation (i.e., the linear dependency) within the measurement vector of a single channel. For the multichannel case, known as the multi-measurement vector (MMV) problem, the Spatio-Temporal Sparse Bayesian Learning (STSBL-EM) method has been proposed. This method learns the joint correlation structure in the multichannel signals by whitening the model in the temporal and the spatial domains. Our proposed method represents the multi-channels signal data as a vector that is constructed in a specific way, so that it has a better block sparsity structure than the conventional representation obtained by stacking the measurement vectors of the different channels. To reconstruct the multichannel EEG signals, we modify the parameters of the BSBL-BO algorithm, so that it can exploit not only the linear but also the non-linear dependency structures in a vector. The modified BSBL-BO is then applied on the vector with the better sparsity structure. The proposed method is shown to significantly outperform existing SMV and also MMV methods. It also shows significant lower compression errors even at high compression ratios such as 10:1 on three different datasets. PMID:26861335

  17. Block Sparse Compressed Sensing of Electroencephalogram (EEG Signals by Exploiting Linear and Non-Linear Dependencies

    Directory of Open Access Journals (Sweden)

    Hesham Mahrous

    2016-02-01

    Full Text Available This paper proposes a compressive sensing (CS method for multi-channel electroencephalogram (EEG signals in Wireless Body Area Network (WBAN applications, where the battery life of sensors is limited. For the single EEG channel case, known as the single measurement vector (SMV problem, the Block Sparse Bayesian Learning-BO (BSBL-BO method has been shown to yield good results. This method exploits the block sparsity and the intra-correlation (i.e., the linear dependency within the measurement vector of a single channel. For the multichannel case, known as the multi-measurement vector (MMV problem, the Spatio-Temporal Sparse Bayesian Learning (STSBL-EM method has been proposed. This method learns the joint correlation structure in the multichannel signals by whitening the model in the temporal and the spatial domains. Our proposed method represents the multi-channels signal data as a vector that is constructed in a specific way, so that it has a better block sparsity structure than the conventional representation obtained by stacking the measurement vectors of the different channels. To reconstruct the multichannel EEG signals, we modify the parameters of the BSBL-BO algorithm, so that it can exploit not only the linear but also the non-linear dependency structures in a vector. The modified BSBL-BO is then applied on the vector with the better sparsity structure. The proposed method is shown to significantly outperform existing SMV and also MMV methods. It also shows significant lower compression errors even at high compression ratios such as 10:1 on three different datasets.

  18. Adaptive Multi-Layered Space-Time Block Coded Systems in Wireless Environments

    KAUST Repository

    Al-Ghadhban, Samir

    2014-12-23

    © 2014, Springer Science+Business Media New York. Multi-layered space-time block coded systems (MLSTBC) strike a balance between spatial multiplexing and transmit diversity. In this paper, we analyze the block error rate performance of MLSTBC. In addition, we propose an adaptive MLSTBC schemes that are capable of accommodating the channel signal-to-noise ratio variation of wireless systems by near instantaneously adapting the uplink transmission configuration. The main results demonstrate that significant effective throughput improvements can be achieved while maintaining a certain target bit error rate.

  19. Integration specially intended for a signal processing system. Structures of programmed and micro-programmed operators for signal processing

    International Nuclear Information System (INIS)

    The aim is to describe the development of programmed and micro-programmed system for signal processing (accumulation, histogram, Fourier transform, correlation, convolution, digital filtering etc...). The following points will be discussed: possibilities and limitations of systems based on universal computers, addition of specialized terminals, specialized computers for signal processing. Two typical laboratory studies will be described: adaptation of basic type advanced languages to signal processing, description of a new structure of operators suitable for treatments of repetitive algorithms on blocks of data

  20. Applied signal processing concepts, circuits, and systems

    CERN Document Server

    Hamdy, Nadder

    2008-01-01

    Introduction What are Signals? Signal parameters Why Signal processing? Analog vs. Digital Signal processing Practical Signal processing Systems Analog Signal Processing Amplitude Shaping Frequency Spectrum Shaping Phase Errors Correction Waveform Generation Analog Filter Design Describing Equations Design Procedures Filter Specifications Approximations to the Ideal Response Realization Practical RC-Filters Design Switched Capacitor Filter Realization Design examples Data Converters Introduction A typical DSP System Specifications of Data Converters Sampling Samp

  1. QuaBingo: A Prediction System for Protein Quaternary Structure Attributes Using Block Composition

    Science.gov (United States)

    Tung, Chi-Hua; Chen, Chi-Wei; Guo, Ren-Chao; Ng, Hui-Fuang

    2016-01-01

    Background. Quaternary structures of proteins are closely relevant to gene regulation, signal transduction, and many other biological functions of proteins. In the current study, a new method based on protein-conserved motif composition in block format for feature extraction is proposed, which is termed block composition. Results. The protein quaternary assembly states prediction system which combines blocks with functional domain composition, called QuaBingo, is constructed by three layers of classifiers that can categorize quaternary structural attributes of monomer, homooligomer, and heterooligomer. The building of the first layer classifier uses support vector machines (SVM) based on blocks and functional domains of proteins, and the second layer SVM was utilized to process the outputs of the first layer. Finally, the result is determined by the Random Forest of the third layer. We compared the effectiveness of the combination of block composition, functional domain composition, and pseudoamino acid composition of the model. In the 11 kinds of functional protein families, QuaBingo is 23% of Matthews Correlation Coefficient (MCC) higher than the existing prediction system. The results also revealed the biological characterization of the top five block compositions. Conclusions. QuaBingo provides better predictive ability for predicting the quaternary structural attributes of proteins.

  2. QuaBingo: A Prediction System for Protein Quaternary Structure Attributes Using Block Composition

    Directory of Open Access Journals (Sweden)

    Chi-Hua Tung

    2016-01-01

    Full Text Available Background. Quaternary structures of proteins are closely relevant to gene regulation, signal transduction, and many other biological functions of proteins. In the current study, a new method based on protein-conserved motif composition in block format for feature extraction is proposed, which is termed block composition. Results. The protein quaternary assembly states prediction system which combines blocks with functional domain composition, called QuaBingo, is constructed by three layers of classifiers that can categorize quaternary structural attributes of monomer, homooligomer, and heterooligomer. The building of the first layer classifier uses support vector machines (SVM based on blocks and functional domains of proteins, and the second layer SVM was utilized to process the outputs of the first layer. Finally, the result is determined by the Random Forest of the third layer. We compared the effectiveness of the combination of block composition, functional domain composition, and pseudoamino acid composition of the model. In the 11 kinds of functional protein families, QuaBingo is 23% of Matthews Correlation Coefficient (MCC higher than the existing prediction system. The results also revealed the biological characterization of the top five block compositions. Conclusions. QuaBingo provides better predictive ability for predicting the quaternary structural attributes of proteins.

  3. Heart Block

    Science.gov (United States)

    ... the signal causes the heart to contract and pump blood. Heart block occurs if the electrical signal is ... degree heart block limits the heart's ability to pump blood to the rest of the body. This type ...

  4. EFFECT OF PEDESTRIANS UN-SIGNALIZED MID-BLOCK CROSSING ON VEHICULAR SPEED

    Directory of Open Access Journals (Sweden)

    B Raghuram Kadali

    2015-06-01

    Full Text Available Pedestrian is one of the important component in urban transportation system and also vulnerable at un-protected mid-block locations under mixed traffic conditions. At un-protected mid-block locations, some of the vehicles may yield to pedestrians who are already at crosswalk location. However, some of the pedestrians are using forced gaps to cross the road. Hence, while pedestrians use the mid-block crosswalk with forced gaps, which decreases the vehicular flow characteristics. The pedestrian sidewalks do not show a direct effect on the vehicular flow characteristics when the pedestrian have pleasant walking facilities. The present study has analyzed the effect of pedestrian crossing on the characteristics of vehicular flow at mid-block location under mixed traffic conditions. The results indicate that the pedestrian forced gap condition has significant effect on vehicular characteristics. The study results may be useful for decreasing the travel time for vehicular drivers by controlling usage of pedestrian forced gaps.

  5. Random matrix theory for pseudo-Hermitian systems: Cyclic blocks

    Indian Academy of Sciences (India)

    Sudhir R Jain; Shashi C L Srivastava

    2009-12-01

    We discuss the relevance of random matrix theory for pseudo-Hermitian systems, and, for Hamiltonians that break parity and time-reversal invariance . In an attempt to understand the random Ising model, we present the treatment of cyclic asymmetric matrices with blocks and show that the nearest-neighbour spacing distributions have the same form as obtained for the matrices with scalar entries. We also summarize the theory for random cyclic matrices with scalar entries. We have also found that for block matrices made of Hermitian and pseudo-Hermitian sub-blocks of the form appearing in Ising model depart from the known results for scalar entries. However, there is still similarity in trends even in log–log plots.

  6. PN Sequence Preestimator Scheme for DS-SS Signal Acquisition Using Block Sequence Estimation

    Directory of Open Access Journals (Sweden)

    Sang Kyu Park

    2005-03-01

    Full Text Available An m-sequence (PN sequence preestimator scheme for direct-sequence spread spectrum (DS-SS signal acquisition by using block sequence estimation (BSE is proposed and analyzed. The proposed scheme consists of an estimator and a verifier which work according to the PN sequence chip clock, and provides not only the enhanced chip estimates with a threshold decision logic and one-chip error correction among the first m received chips, but also the reliability check of the estimates with additional decision logic. The probabilities of the estimator and verifier operations are calculated. With these results, the detection, the false alarm, and the missing probabilities of the proposed scheme are derived. In addition, using a signal flow graph, the average acquisition time is calculated. The proposed scheme can be used as a preestimator and easily implemented by changing the internal signal path of a generally used digital matched filter (DMF correlator or any other correlator that has a lot of sampling data memories for sampled PN sequence. The numerical results show rapid acquisition performance in a relatively good CNR.

  7. PN Sequence Preestimator Scheme for DS-SS Signal Acquisition Using Block Sequence Estimation

    Science.gov (United States)

    Hyun, Kwangmin; Yoon, Dongweon; Park, Sang Kyu

    2005-12-01

    An [InlineEquation not available: see fulltext.]-sequence (PN sequence) preestimator scheme for direct-sequence spread spectrum (DS-SS) signal acquisition by using block sequence estimation (BSE) is proposed and analyzed. The proposed scheme consists of an estimator and a verifier which work according to the PN sequence chip clock, and provides not only the enhanced chip estimates with a threshold decision logic and one-chip error correction among the first [InlineEquation not available: see fulltext.] received chips, but also the reliability check of the estimates with additional decision logic. The probabilities of the estimator and verifier operations are calculated. With these results, the detection, the false alarm, and the missing probabilities of the proposed scheme are derived. In addition, using a signal flow graph, the average acquisition time is calculated. The proposed scheme can be used as a preestimator and easily implemented by changing the internal signal path of a generally used digital matched filter (DMF) correlator or any other correlator that has a lot of sampling data memories for sampled PN sequence. The numerical results show rapid acquisition performance in a relatively good CNR.

  8. Dual use of LED traffic signal system

    OpenAIRE

    Cheung, SW; Yang, ES; Tam, YY; Man, CW; D. Yang

    1999-01-01

    The dual use, signaling and communication, of LED traffic signal system is described and analyzed. The primary function of a traffic light system is to give traffic and pedestrian signals. A prototype of LED traffic signal head is developed to perform a secondary function: communication. A wireless communication link is set up using the LED traffic signal head as the transmitter. The LEDs are modulated to transmit information-carrying light. The receiver uses a silicon photodiode to detect th...

  9. Impact of Carrier Frequency Offsets on Block-IFDMA Systems

    Directory of Open Access Journals (Sweden)

    Simon EP

    2009-01-01

    Full Text Available Recently, a new multiple access (MA scheme called block-interleaved frequency division multiple access (B-IFDMA is under consideration as an MA scheme candidate for 4G wireless applications. In this paper, the two variants of B-IFDMA are considered, the joint- DFT B-IFDMA and the added-signal B-IFDMA, and compared in terms of sensitivity to carrier frequency offsets (CFOs for both uplink and downlink. CFO gives rise to multiuser interference and self-user interference. We derive analytical expressions for the power of these interferences, and we quantify their detrimental effect through the evaluation of the signal-to-interference-plus-noise ratio (SINR degradation. We point out that both variants of B-IFDMA are not similarly affected by CFO. Hence, joint-DFT B-IFDMA provides a better robustness to multiuser interference than added-signal B-IFDMA, and so is better suited for the uplink. Then we show by means of numerical results that added-signal B-IFDMA is less sensitive to CFO in the downlink.

  10. Investigating complex patterns of blocked intestinal artery blood pressure signals by empirical mode decomposition and linguistic analysis

    International Nuclear Information System (INIS)

    In this investigation, surgical operations of blocked intestinal artery have been conducted on pigs to simulate the condition of acute mesenteric arterial occlusion. The empirical mode decomposition method and the algorithm of linguistic analysis were applied to verify the blood pressure signals in simulated situation. We assumed that there was some information hidden in the high-frequency part of the blood pressure signal when an intestinal artery is blocked. The empirical mode decomposition method (EMD) has been applied to decompose the intrinsic mode functions (IMF) from a complex time series. But, the end effects and phenomenon of intermittence damage the consistence of each IMF. Thus, we proposed the complementary ensemble empirical mode decomposition method (CEEMD) to solve the problems of end effects and the phenomenon of intermittence. The main wave of blood pressure signals can be reconstructed by the main components, identified by Monte Carlo verification, and removed from the original signal to derive a riding wave. Furthermore, the concept of linguistic analysis was applied to design the blocking index to verify the pattern of riding wave of blood pressure using the measurements of dissimilarity. Blocking index works well to identify the situation in which the sampled time series of blood pressure signal was recorded. Here, these two totally different algorithms are successfully integrated and the existence of the existence of information hidden in high-frequency part of blood pressure signal has been proven

  11. Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells.

    Science.gov (United States)

    Bao, Renyue; Christova, Tania; Song, Siyuan; Angers, Stephane; Yan, Xiaojun; Attisano, Liliana

    2012-01-01

    Constitutive Wnt signalling is characterized by excessive levels of β-catenin protein and is a frequent occurrence in cancer. APC and Axin are key components of the β-catenin destruction complex that acts to promote β-catenin degradation. The levels of Axin are in turn controlled by tankyrases, members of the PARP-family of poly-ADP-ribosylation enzymes. In colorectal cancer cells, which typically harbor APC mutations, inhibition of tankyrase activity promotes Axin stabilization and attenuates Wnt signalling. Here, we examined the effect of inhibiting tankyrases in breast cancer cells with normal APC. We show that application of the small molecule tankyrase inhibitor, XAV939 or siRNA-mediated abrogation of tankyrase expression increases Axin1 and Axin2 protein levels and attenuates Wnt-induced transcriptional responses in several breast cancer lines. In MDA-MB-231 cells, inhibiton of tankyrase activity also attenuate Wnt3a induced cell migration. Moreover, in both MDA-MB-231 and colorectal cancer cells, XAV939 inhibits cell growth under conditions of serum-deprivation. However, the presence of serum prevents this growth inhibitory effect, although inhibition of Wnt-induced transcriptional and migratory responses was maintained. These results indicate that stabilization of Axin by inhibition of tankyrases alone, may not be an effective means to block tumor cell growth and that combinatorial therapeutic approaches should be considered. PMID:23144924

  12. Decomposition method for block-tridiagonal matrix systems

    CERN Document Server

    Belov, P A; Yakovlev, S L

    2015-01-01

    The decomposition method which makes the parallel solution of the block-tridiagonal matrix systems possible is presented. The performance of the method is analytically estimated based on the number of elementary multiplicative operations for its parallel and serial parts. The computational speedup with respect to the conventional sequential Thomas algorithm is assessed for various types of the application of the method. It is observed that the maximum of the analytical speedup for a given number of blocks on the diagonal is achieved at some finite number of parallel processors. The values of the parameters required to reach the maximum computational speedup are obtained. The benchmark calculations show a good agreement of analytical estimations of the computational speedup and practically achieved results. The application of the method is illustrated by employing the decomposition method to the matrix system originated from a boundary value problem for the two-dimensional integro-differential Faddeev equation...

  13. Decomposition method for block-tridiagonal matrix systems

    OpenAIRE

    Belov, P. A.; Nugumanov, E. R.; Yakovlev, S. L.

    2015-01-01

    The decomposition method which makes the parallel solution of the block-tridiagonal matrix systems possible is presented. The performance of the method is analytically estimated based on the number of elementary multiplicative operations for its parallel and serial parts. The computational speedup with respect to the conventional sequential Thomas algorithm is assessed for various types of the application of the method. It is observed that the maximum of the analytical speedup for a given num...

  14. Systems theory of Smad signaling

    OpenAIRE

    Clarke, D. C.; Betterton, M D; Liu, X

    2006-01-01

    Transforming Growth Factor-beta (TGF-beta) signalling is an important regulator of cellular growth and differentiation. The principal intracellular mediators of TGF-beta signalling are the Smad proteins, which upon TGF-beta stimulation accumulate in the nucleus and regulate transcription of target genes. To investigate the mechanisms of Smad nuclear accumulation, we developed a simple mathematical model of canonical Smad signalling. The model was built using both published data and our experi...

  15. Block design enhances classification of 3D reach targets from electroencephalographic signals.

    Science.gov (United States)

    Sosnik, Ronen; Tadipatri, Vijay Aditya; Tewfik, Ahmed H; Pellizzer, Giuseppe

    2016-08-01

    To date, decoding accuracy of actual or imagined pointing movements to targets in 3D space from electroencephalographic (EEG) signals has remained modest. The reason may pertain to the fact that these movements activate essentially the same neural networks. In this study, we aimed at testing whether repetitive pointing movements to each of the targets promotes the development of segregated neural patterns, resulting in enhanced decoding accuracy. Six human subjects generated slow or fast repetitive pointing movements with their right dominant arm to one of five targets distributed in 3D space, followed by repetitive imagery of movements to the same target or to a different target. Nine naive subjects generated both repetitive and non-repetitive slow actual movements to each of the five targets to test the effect of block design on decoding accuracy. In order to assure that base line drift and low frequency motion artifacts do not contaminate the data, the data were high-pass filtered in 4-30Hz, leaving out the delta and gamma band. For the repetitive trials, the model decoded target location with 81% accuracy, which is significantly higher than chance level. The average decoding rate of target location was only 30% for the non-repetitive trials, which is not significantly different than chance level. A subset of electrodes, mainly over the contralateral sensorimotor areas, was found to provide most of the discriminative features for all tested conditions. Time proximity between trained and tested blocks was found to enhance decoding accuracy of target location both by target non-specific and specific mechanisms. Our findings suggest that movement repetition promotes the development of distinct neural patterns, presumably by the formation of target-specific kinesthetic memory. PMID:27223628

  16. Multiprocessor schemes for solving block tridiagonal linear systems

    Energy Technology Data Exchange (ETDEWEB)

    Berry, M.W.; Sameh, A. (Univ. of Illinois at Urbana-Champaign, Urbana, IL (US))

    1988-01-01

    The solution of large, banded diagonally dominant or symmetric positive definite linear systems constitutes one of the most common computational tasks associated with implementations of the finite element method in applications such as fluid dynamics and structural analysis. Thus, designing multiprocessor algorithms for solving large block tridiagonal systems becomes of paramount importance for efficient implementation of these applications on vector and parallel machines. The authors present such schemes here, along with specific performance results on the Alliant FX/8 and CRAY X-MP 48. They particularly emphasize the speedups obtained with these schemes over popular direct band solvers. The development of a candidate scheme for the multicluster CEDAR machine is their goal.

  17. Blocking p55PIK signaling inhibits proliferation and induces differentiation of leukemia cells.

    Science.gov (United States)

    Wang, G; Deng, Y; Cao, X; Lai, S; Tong, Y; Luo, X; Feng, Y; Xia, X; Gong, J; Hu, J

    2012-11-01

    p55PIK, a regulatory subunit of phosphatidylinositol 3-kinases, promotes cell cycle progression by interacting with cell cycle modulators such as retinoblastoma protein (Rb) via its unique amino-terminal 24 amino-acid residue (N24). Overexpression of N24 specifically inhibits these interactions and leads to cell cycle arrest. Herein, we describe the generation of a fusion protein (Tat transactivator protein (TAT)-N24) that contains the protein transduction domain and N24, and examined its effects on the proliferation and differentiation of leukemia cells. TAT-N24 not only blocks cell proliferation but remarkably induces differentiation of leukemia cells in vitro and in vivo. Systemically administered TAT-N24 also significantly decreases growth of leukemia cell tumors in animal models. Furthermore, overexpression of p55PIK in leukemia cells leads to increased proliferation; however, TAT-N24 blocks this effect and concomitantly induces differentiation. There is significant upregulation of p55PIK mRNA and protein expression in leukemia cells from patients. TAT-N24 inhibits cell cycle progression and induces differentiation of bone marrow cells derived from patients with several different types of leukemia. These results show that cell-permeable N24 peptide induces leukemia cell differentiation and suggest that p55PIK may be a novel drug target for the treatment of hematopoetic malignancies. PMID:22722333

  18. Kalkitoxin Inhibits Angiogenesis, Disrupts Cellular Hypoxic Signaling, and Blocks Mitochondrial Electron Transport in Tumor Cells

    Directory of Open Access Journals (Sweden)

    J. Brian Morgan

    2015-03-01

    Full Text Available The biologically active lipopeptide kalkitoxin was previously isolated from the marine cyanobacterium Moorea producens (Lyngbya majuscula. Kalkitoxin exhibited N-methyl-d-aspartate (NMDA-mediated neurotoxicity and acted as an inhibitory ligand for voltage-sensitive sodium channels in cultured rat cerebellar granule neurons. Subsequent studies revealed that kalkitoxin generated a delayed form of colon tumor cell cytotoxicity in 7-day clonogenic cell survival assays. Cell line- and exposure time-dependent cytostatic/cytotoxic effects were previously observed with mitochondria-targeted inhibitors of hypoxia-inducible factor-1 (HIF-1. The transcription factor HIF-1 functions as a key regulator of oxygen homeostasis. Therefore, we investigated the ability of kalkitoxin to inhibit hypoxic signaling in human tumor cell lines. Kalkitoxin potently and selectively inhibited hypoxia-induced activation of HIF-1 in T47D breast tumor cells (IC50 5.6 nM. Mechanistic studies revealed that kalkitoxin inhibits HIF-1 activation by suppressing mitochondrial oxygen consumption at electron transport chain (ETC complex I (NADH-ubiquinone oxidoreductase. Further studies indicate that kalkitoxin targets tumor angiogenesis by blocking the induction of angiogenic factors (i.e., VEGF in tumor cells.

  19. Oxethazaine inhibits hepatitis B virus capsid assembly by blocking the cytosolic calcium-signalling pathway.

    Science.gov (United States)

    Zhang, Lin; Liu, Chunlan; Xiao, Yu; Chen, Xulin

    2016-05-01

    Chronic hepatitis B virus (HBV) infection is a serious public health problem and may progress to liver fibrosis, cirrhosis and hepatocellular carcinoma. It is currently treated with PEGylated IFN-α2a and nucleoside/nucleotide analogues (NAs). However, PEGylated IFN treatment has problems of high cost, low efficiency and side effects. Long-term administration of NAs is necessary to avoid virus relapse, which can cause drug resistance and side effects. New efforts are now being directed to develop novel anti-HBV drugs targeting either additional viral targets other than viral DNA polymerase or host targets to improve the treatment of chronic hepatitis B. In this study, we discovered that oxethazaine, approved for clinic use in a few countries such as Japan, India, South Africa and Brazil, can dose-dependently reduce the levels of HBV envelope antigen, extracellular HBV DNA in supernatants and intracellular HBV total DNA. However, the levels of HBV cccDNA and HBV RNAs were not affected by oxethazaine treatment. Further study confirmed that oxethazaine acts on the virus assembly stage of the HBV life cycle. A study of the mechanisms of oxethazaine suggested that this drug inhibits HBV replication and capsid assembly by blocking the cytosolic calcium-signalling pathway. Moreover, oxethazaine could inhibit the replication of lamivudine/entecavir-dual-resistant and adefovir-resistant HBV mutants. In conclusion, our study suggests that oxethazaine may serve as a promising drug, or could be used as a starting point for anti-HBV drug discovery. PMID:26838678

  20. Signals and systems primer with Matlab

    CERN Document Server

    Poularikas, Alexander D

    2006-01-01

    Signals and Systems Primer with MATLAB® equally emphasizes the fundamentals of both analog and digital signals and systems. To ensure insight into the basic concepts and methods, the text presents a variety of examples that illustrate a wide range of applications, from microelectromechanical to worldwide communication systems. It also provides MATLAB functions and procedures for practice and verification of these concepts.Taking a pedagogical approach, the author builds a solid foundation in signal processing as well as analog and digital systems. The book first introduces orthogonal signals,

  1. 76 FR 21943 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System

    Science.gov (United States)

    2011-04-19

    ...) seeks approval of the proposed discontinuance and removal of the automatic block signal system (ABS) on... Railroad Signal System Pursuant to Title 49 Code of Federal Regulations (CFR) Part 235 and 49 U.S.C. 20502... for the discontinuance or modification of the signal system, as detailed below. Docket Number...

  2. 77 FR 31429 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System

    Science.gov (United States)

    2012-05-25

    ... approval of the proposed discontinuance of an automatic block signal (ABS) system and a traffic control... Railroad Signal System In accordance with Part 235 of Title 49 Code of Federal Regulations (CFR) and 49 U.S...) seeking approval for the discontinuance or modification of a signal system. FRA assigned the...

  3. Augmented reality guidance system for peripheral nerve blocks

    Science.gov (United States)

    Wedlake, Chris; Moore, John; Rachinsky, Maxim; Bainbridge, Daniel; Wiles, Andrew D.; Peters, Terry M.

    2010-02-01

    Peripheral nerve block treatments are ubiquitous in hospitals and pain clinics worldwide. State of the art techniques use ultrasound (US) guidance and/or electrical stimulation to verify needle tip location. However, problems such as needle-US beam alignment, poor echogenicity of block needles and US beam thickness can make it difficult for the anesthetist to know the exact needle tip location. Inaccurate therapy delivery raises obvious safety and efficacy issues. We have developed and evaluated a needle guidance system that makes use of a magnetic tracking system (MTS) to provide an augmented reality (AR) guidance platform to accurately localize the needle tip as well as its projected trajectory. Five anesthetists and five novices performed simulated nerve block deliveries in a polyvinyl alcohol phantom to compare needle guidance under US alone to US placed in our AR environment. Our phantom study demonstrated a decrease in targeting attempts, decrease in contacting of critical structures, and an increase in accuracy of 0.68 mm compared to 1.34mm RMS in US guidance alone. Currently, the MTS uses 18 and 21 gauge hypodermic needles with a 5 degree of freedom sensor located at the needle tip. These needles can only be sterilized using an ethylene oxide process. In the interest of providing clinicians with a simple and efficient guidance system, we also evaluated attaching the sensor at the needle hub as a simple clip-on device. To do this, we simultaneously performed a needle bending study to assess the reliability of a hub-based sensor.

  4. Accuracy guaranties for $\\ell_1$ recovery of block-sparse signals

    OpenAIRE

    Juditsky, Anatoli; Karzan, Fatma Kılınç; Nemirovski, Arkadi; Polyak, Boris

    2011-01-01

    We introduce a general framework to handle structured models (sparse and block-sparse with possibly overlapping blocks). We discuss new methods for their recovery from incomplete observation, corrupted with deterministic and stochastic noise, using block-$\\ell_{1}$ regularization. While the current theory provides promising bounds for the recovery errors under a number of different, yet mostly hard to verify conditions, our emphasis is on verifiable conditions on the problem parameters (sensi...

  5. Sonic hedgehog signaling during nervous system development

    Institute of Scientific and Technical Information of China (English)

    Qin Yang; Peng Xie

    2008-01-01

    The Hedgehog signaling pathway plays a key role in embryonic development and organ formation.Sonic hedgehog signaling participates in nervous system development,regulates proliferation and differentiation of neural stem cells,controls growth and targeting of axons,and contributes to specialization of oligodendrocytes.For further studies of the Sonic hedgehog signaling pathway and for the development of new drugs in the treatment of nervous system diseases,it is beneficial to understand these mechanisms.

  6. Detection of combustion start in the controlled auto ignition engine by wavelet transform of the engine block vibration signal

    International Nuclear Information System (INIS)

    The CAI (controlled auto ignition) engine ignites fuel and air mixture by trapping high temperature burnt gas using a negative valve overlap. Due to auto ignition in CAI combustion, efficiency improvements and low level NOx emission can be obtained. Meanwhile, the CAI combustion regime is restricted and control parameters are limited. The start of combustion data in the compressed ignition engine are most critical for controlling the overall combustion. In this research, the engine block vibration signal is transformed by the Meyer wavelet to analyze CAI combustion more easily and accurately. Signal acquisition of the engine block vibration is a more suitable method for practical use than measurement of in-cylinder pressure. A new method for detecting combustion start in CAI engines through wavelet transformation of the engine block vibration signal was developed and results indicate that it is accurate enough to analyze the start of combustion. Experimental results show that wavelet transformation of engine block vibration can track the start of combustion in each cycle. From this newly developed method, the start of combustion data in CAI engines can be detected more easily and used as input data for controlling CAI combustion

  7. Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats

    Directory of Open Access Journals (Sweden)

    Yang Jia-Le

    2012-05-01

    Full Text Available Abstract Background Spinal glia, particularly microglia and astrocytes, are of the utmost importance in the development and maintenance of chronic pain. A recent study from our laboratory revealed that gabapentin, a recommended first-line treatment for multiple neuropathic conditions, could also efficiently antagonize thermal hyperalgesia evoked by complete Freund's adjuvant (CFA-induced monoarthritis (MA. In the present study, we investigated whether the spinal glia are involved in the anti-hyperalgesic effect of gabapentin and how this event occurs. Results Unilateral intra-articular injection of CFA produced a robust activation of microglia and astrocytes. These cells exhibited large cell bodies, thick processes and increases in the ionized calcium binding adapter molecule 1 (Iba-1, a microglial marker or the glia fibrillary acidic protein (GFAP, an astrocytic marker. These cells also displayed immunoreactive signals, and an upregulation of the voltage-gated calcium channels (VGCCs α2/δ-1 subunit, CX3CL1 and CX3CR1 expression levels in the spinal cord. These changes were associated with the development of thermal hyperalgesia. Immunofluorescence staining showed that VGCC α2/δ-1 subunit, a proposed gabapentin target of action, was widely distributed in primary afferent fibers terminals and dorsal horn neurons. CX3CL1, a potential trigger to activate microglia, colocalized with VGCC α2/δ-1 subunits in the spinal dorsal horn. However, its receptor CX3CR1 was mainly expressed in the spinal microglia. Multiple intraperitoneal (i.p. gabapentin injections (100 mg/kg, once daily for 4 days with the first injection 60 min before intra-articular CFA suppressed the activation of spinal microglia, downregulated spinal VGCC α2/δ-1 subunits decreased CX3CL1 levels and blocked the development of thermal hyperalgesia in MA rats. Conclusions Here we provide the first evidence that gabapentin diminishes CX3CL1 signaling and spinal microglia

  8. Intelligent Multimodal Signal Adaptation System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Micro Analysis and Design (MA&D) is pleased to submit this proposal to design an Intelligent Multimodal Signal Adaptation System. This system will dynamically...

  9. The Blocks database--a system for protein classification.

    OpenAIRE

    Pietrokovski, S; Henikoff, J G; Henikoff, S.

    1996-01-01

    The Blocks Database contains multiple alignments of conserved regions in protein families. The database can be searched by e-mail and World Wide Web(WWW) servers (http://blocks.fhcrc.org/help) to classify protein and nucleotide sequences.

  10. Efficient spread space-time block coding scheme in multiple antenna systems

    Institute of Scientific and Technical Information of China (English)

    Qiu Ling; Zheng Xiayu

    2006-01-01

    Space-time coding is an important technique that can improve transmission performance at fading environments in mobile communication systems. In this paper, we propose a novel diversity scheme using spread spacetime block coding (SSTBC) in multiple antenna systems. At the transmitter, the primitive data are serial to parallel converted to multiple data streams, and each stream is rotated in constellation. Then Walsh codes are used to spread each symbol to all antenna space in a space-time block. The signals received from all receiver antennas are combined with the maximum ratio combining (MRC), equalized with linear equalizer to eliminate the inter-code interference and finally demodulated to recover to transmit data by using the one-symbol maximum likelihood detector. The proposed scheme does not sacrifice the spectrum efficiency meanwhile maintains the transceiver with low complexity. Owing to the transmission symbols of different transmit antennas passing through all the spatial subchannels between transceiver antenna pairs, the system obtains the partial additional space diversity gain of all spatial paths. It is also shown that the diversity gain is better than the previous space-time block coding (STBC) schemes with full transmission rate.

  11. Aerial multi-camera systems: Accuracy and block triangulation issues

    Science.gov (United States)

    Rupnik, Ewelina; Nex, Francesco; Toschi, Isabella; Remondino, Fabio

    2015-03-01

    Oblique photography has reached its maturity and has now been adopted for several applications. The number and variety of multi-camera oblique platforms available on the market is continuously growing. So far, few attempts have been made to study the influence of the additional cameras on the behaviour of the image block and comprehensive revisions to existing flight patterns are yet to be formulated. This paper looks into the precision and accuracy of 3D points triangulated from diverse multi-camera oblique platforms. Its coverage is divided into simulated and real case studies. Within the simulations, different imaging platform parameters and flight patterns are varied, reflecting both current market offerings and common flight practices. Attention is paid to the aspect of completeness in terms of dense matching algorithms and 3D city modelling - the most promising application of such systems. The experimental part demonstrates the behaviour of two oblique imaging platforms in real-world conditions. A number of Ground Control Point (GCP) configurations are adopted in order to point out the sensitivity of tested imaging networks and arising block deformations. To stress the contribution of slanted views, all scenarios are compared against a scenario in which exclusively nadir images are used for evaluation.

  12. Research on Portable Fatigue Signal Detection System

    Directory of Open Access Journals (Sweden)

    Bowen Li

    2013-07-01

    Full Text Available According to the characteristics of human pulse wave signals, the acquisition system acquisition system with excellent performance is designed, 16 bit MCU MSP430 with ultralow power is used to record, process and transmit the collected pulse wave signals. In order to make the hardware part satisfy acquisition requirements of pulse wave, the paper focuses on discussing composition, operating principle, analysis method and performance parameter of analog circuit. The software part makes use of the design tools of Matlab graphical user interface (GUI for designing pulse wave signal measurement system. The trial on intelligent fatigue test signal adopts relatively unique methods no matter in hardware circuit design or software algorithm process, which provides important and meaningful reference for objective and quantitative research on fatigue signal.

  13. A Parallel Framework with Block Matrices of a Discrete Fourier Transform for Vector-Valued Discrete-Time Signals

    Directory of Open Access Journals (Sweden)

    Pablo Soto-Quiros

    2015-01-01

    Full Text Available This paper presents a parallel implementation of a kind of discrete Fourier transform (DFT: the vector-valued DFT. The vector-valued DFT is a novel tool to analyze the spectra of vector-valued discrete-time signals. This parallel implementation is developed in terms of a mathematical framework with a set of block matrix operations. These block matrix operations contribute to analysis, design, and implementation of parallel algorithms in multicore processors. In this work, an implementation and experimental investigation of the mathematical framework are performed using MATLAB with the Parallel Computing Toolbox. We found that there is advantage to use multicore processors and a parallel computing environment to minimize the high execution time. Additionally, speedup increases when the number of logical processors and length of the signal increase.

  14. Systems Biology Analysis of Heterocellular Signaling.

    Science.gov (United States)

    Tape, Christopher J

    2016-08-01

    Tissues comprise multiple heterotypic cell types (e.g., epithelial, mesenchymal, and immune cells). Communication between heterotypic cell types is essential for biological cohesion and is frequently dysregulated in disease. Despite the importance of heterocellular communication, most systems biology techniques do not report cell-specific signaling data from mixtures of cells. As a result, our existing perspective of cellular behavior under-represents the influence of heterocellular signaling. Recent technical advances now permit the resolution of systems-level cell-specific signaling data. This review discusses how new physical, spatial, and isotopic resolving methods are facilitating unique systems biology studies of heterocellular communication. PMID:27087613

  15. VLSI systems design for digital signal processing. Volume 1 - Signal processing and signal processors

    Science.gov (United States)

    Bowen, B. A.; Brown, W. R.

    This book is concerned with the design of digital signal processing systems which utilize VLSI (Very Large Scale Integration) components. The presented material is intended for use by electrical engineers at the senior undergraduate or introductory graduate level. It is the purpose of this volume to present an overview of the important elements of background theory, processing techniques, and hardware evolution. Digital signals are considered along with linear systems and digital filters, taking into account the transform analysis of deterministic signals, a statistical signal model, time domain representations of discrete-time linear systems, and digital filter design techniques and implementation issues. Attention is given to aspects of detection and estimation, digital signal processing algorithms and techniques, issues which must be resolved in a processor design methodology, the fundamental concepts of high performance processing in terms of two early super computers, and the extension of these concepts to more recent processors.

  16. AMPK inhibition blocks ROS-NFκB signaling and attenuates endotoxemia-induced liver injury.

    Directory of Open Access Journals (Sweden)

    Yuan Guo

    Full Text Available BACKGROUND: AMP-activated protein kinase (AMPK is an important enzyme in regulation of cellular energy homeostasis. We have previously shown that AMPK activation by 5-aminoimidazole-4-carboxamide (AICAR results in suppression of immune responses, indicating the pivotal role of AMPK in immune regulation. However, the cellular mechanism underpinning AMPK inhibition on immune response remains largely to be elucidated. The study aimed to investigate the effects of AMPK inhibition on reactive oxygen species (ROS-nuclear factor κB (NFκB signaling and endotoxemia-induced liver injury. METHODOLOGY/PRINCIPAL FINDINGS: RAW 264.7 cells were pretreated with AMPK activator or inhibitor, followed by LPS challenge. In addition, LPS was injected intraperitoneally into mice to induce systemic inflammation. The parameters of liver injury and immune responses were determined, and survival of mice was monitored respectively. LPS challenge in RAW 264.7 cells resulted in AMPK activation which was then inhibited by compound C treatment. Both AMPK activation by AICAR or inhibition by compound C diminished LPS-induced ROS generation, inhibited phosphorylation of IKK, IκB, and NFκB p65, and consequently, decreased TNF production of RAW 264.7 cells. AICAR or compound C treatment decreased ALT, AST, and TNF levels in serum, reduced CD68 expression and MPO activity in liver tissue of mice with endotoxemia. Moreover, AICAR or compound C treatment improved survival of endotoxemic mice. CONCLUSIONS: AICAR or compound C treatment attenuates LPS-induced ROS-NFκB signaling, immune responses and liver injury. Strategies to activate or inhibit AMPK signaling may provide alternatives to the current clinical approaches to inhibit immune responses of endotoxemia.

  17. Design of a Real-time Signal Processing System for LIF Sensor

    Energy Technology Data Exchange (ETDEWEB)

    Zhao Xiande; Zheng Wengang; Dong Daming; Shen Changjun; Zhang Xin; Zhou Jianjun; Yan Hua; Wu Wenbiao, E-mail: zhengwg@nercita.org.cn [National Engineering Research Center for Information Technology in Agriculture, 100097 (China)

    2011-02-01

    Laser Induced Fluorescence (LIF) sensor is one of the most sensitive approaches available for a variety of analytical applications, such as determination of nitrogen content of plant leaves, detection of chlorophyll content in water, etal. As a core instrumental requirements of real time LIF sensor, signal processing system is used to store effective processing and identification algorithms in a short time. By analyzing the working principle of LIF sensor in detail, a novel platform of signal processing system used in LIF sensor is proposed in this paper. The design solutions and hardware architecture of the system are described in this paper, include Digital Signal Processor (DSP), data transmission block, and memory block. Several steps of signal processing methods are proposed, according to the characteristic of LIF sensor. At last, an application of using the signal processing system designed in this paper for measuring chlorophyll content in plant leaves is shown.

  18. Capturing blocked-entrance binaural signals from open-entrance recordings

    DEFF Research Database (Denmark)

    Hammershøi, Dorte; Hoffmann, Pablo F.; Olesen, Søren Krarup;

    2008-01-01

    Binaural recordings enable us to capture all sound attributes including spatial information, room effect, and source characteristics in a given environment. It has been shown that blocked-entrance binaural recordings provide advantages over open-entrance recordings, primarily because the blocked-...... context. To this purpose, equalization filters are derived from the ratio between blocked and open ear canal transfer functions. Different transfer-function measuring techniques and inverse filtering methods are evaluated.......Binaural recordings enable us to capture all sound attributes including spatial information, room effect, and source characteristics in a given environment. It has been shown that blocked-entrance binaural recordings provide advantages over open-entrance recordings, primarily because the blocked......-entrance recordings is not influenced by the ear canal acoustics of the individual for which it is recorded. However, blocking the ear canal for recoding imposes an obvious disruption to normal hearing conditions, which may be unacceptable for applications in which binaural audio capturing is desired but without...

  19. Signal processing by the endosomal system.

    Science.gov (United States)

    Villaseñor, Roberto; Kalaidzidis, Yannis; Zerial, Marino

    2016-04-01

    Cells need to decode chemical or physical signals from their environment in order to make decisions on their fate. In the case of signalling receptors, ligand binding triggers a cascade of chemical reactions but also the internalization of the activated receptors in the endocytic pathway. Here, we highlight recent studies revealing a new role of the endosomal network in signal processing. The diversity of entry pathways and endosomal compartments is exploited to regulate the kinetics of receptor trafficking, and interactions with specific signalling adaptors and effectors. By governing the spatio-temporal distribution of signalling molecules, the endosomal system functions analogously to a digital-analogue computer that regulates the specificity and robustness of the signalling response. PMID:26921695

  20. SYSTEM ANALYSIS OF DISCIPLINARY-BLOCK TRAINING PRINCIPLE

    OpenAIRE

    A. S. Mikhalev

    2014-01-01

    A traditional approach to organization of group-training method leads to rather sharp contra-dictions of «discreteness», «assortment» and «asynchronicity». A disciplinary-block training principle overcomes the indicated contradictions owing to breaking-up a term and a term disciplinary set in blocks, consecutive study of every block and distribution of examinations in «butt joints» between the blocks. The paper shows that the principle significantly improves important properties of education ...

  1. Inhibition of Notch Signaling Blocks Growth of Glioblastoma Cell Lines and Tumor Neurospheres

    OpenAIRE

    Chen, Jie; Kesari, Santosh; Rooney, Christine; Strack, Peter R.; Chen, Jihua; Shen, Huangxuan; Wu, Lizi; Griffin, James D.

    2010-01-01

    Glioblastoma (GBM) is the most common malignant brain tumor that is characterized by high proliferative rate and invasiveness. Since dysregulation of Notch signaling is implicated in the pathogenesis of many human cancers, here we investigated the role of Notch signaling in GBM. We found that there is aberrant activation of Notch signaling in GBM cell lines and human GBM-derived neurospheres. Inhibition of Notch signaling via the expression of a dominant negative form of the Notch coactivator...

  2. A Note on the Use of the Woodbury Formula To Solve Cyclic Block Tri-Diagonal and Cyclic Block Penta-diagonal Linear Systems of Equations

    CERN Document Server

    Batista, Milan

    2008-01-01

    The article presents the theoretical background of the algorithms for solving cyclic block tridiagonal and cyclic block penta-diagonal systems of linear algebraic equations present in [1] and [2]. The theory is based on the Woodbury formula.

  3. A novel power swing blocking scheme using adaptive neuro-fuzzy inference system

    Energy Technology Data Exchange (ETDEWEB)

    Zadeh, Hassan Khorashadi; Li, Zuyi [Illinois Institute of Technology, Department of Electrical and Computer Engineering, 3301 S. Dearborn Street, Chicago, IL 60616 (United States)

    2008-07-15

    A power swing may be caused by any sudden change in the configuration or the loading of an electrical network. During a power swing, the impedance locus moves along an impedance circle with possible encroachment into the distance relay zone, which may cause an unnecessary tripping. In order to prevent the distance relay from tripping under such condition, a novel power swing blocking (PSB) scheme is proposed in this paper. The proposed scheme uses an adaptive neuro-fuzzy inference systems (ANFIS) for preventing distance relay from tripping during power swings. The input signals to ANFIS, include the change of positive sequence impedance, positive and negative sequence currents, and power swing center voltage. Extensive tests show that the proposed PSB has two distinct features that are advantageous over existing schemes. The first is that the proposed scheme is able to detect various kinds of power swings thus block distance relays during power swings, even if the power swings are fast or the power swings occur during single pole open conditions. The second distinct feature is that the proposed scheme is able to clear the blocking if faults occur within the relay trip zone during power swings, even if the faults are high resistance faults, or the faults occur at the power swing center, or the faults occur when the power angle is close to 180 . (author)

  4. COMPLEMENT BLOCK CODING SCHEME FOR REDUCING PEAK-TO-AVERAGE POWER RATIO OF OFDM SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    Jiang Tao; Zhu Guangxi

    2004-01-01

    A new scheme termed as Complement Block Coding (CBC) technique is proposed to reduce the Peak-to-Average Power Ratio (PAPR) of OFDM signals. Utilizing the complement bits which are added to the original information bits,this method can effectively reduce the PAPR of OFDM systems with random frame size N and the coding rate R ≤ (N - k)/N, where kis a positive integer and k ≤ N/2. The performance results obtained with CBC are given and compared with that of some well known schemes, such as Simple Block Coding (SBC), Modified Simple Block Coding (MSBC) and Simple Odd Parity Code (SOPC) for the same purpose. The results show that, at the same coding rate 3/4, the CBC can achieve almost the same performance as SBC, MSBC, but with lower complexity, and that the same performance can be obtained with higher coding rate by using CBC. At the same coding rate (N - 1)/N, the PAPR reduction of CBC is almost the twice as that of SOPC when N ≥ 16. Further more, the PAPR reductions with coding rate (N - 1)/N are almost the same as that with coding rate less than (N - 1)/N,so the proposed scheme CBC is more suitable for the large frame size with high coding rate and can provide error detection.

  5. A Method for Solving Cyclic Block Penta-diagonal Systems of Linear Equations

    CERN Document Server

    Batista, Milan

    2008-01-01

    The method for solving cyclic block three-diagonal systems of equations is generalized for solving a block cyclic penta-diagonal system of equations. Introducing a special form of two new variables the original system is split into three block pentagonal systems, which can be solved by the known methods. As such method belongs to class of direct methods without pivoting. Implementation of the algorithm is discussed in some details and the numerical examples are present.

  6. A Method for Solving Cyclic Block Penta-diagonal Systems of Linear Equations

    OpenAIRE

    Batista, Milan

    2008-01-01

    A method for solving cyclic block three-diagonal systems of equations is generalized for solving a block cyclic penta-diagonal system of equations. Introducing a special form of two new variables the original system is split into three block pentagonal systems, which can be solved by the known methods. As such method belongs to class of direct methods without pivoting. Implementation of the algorithm is discussed in some details and the numerical examples are present.

  7. Active angular alignment of gauge block in system for contactless gauge block calibration

    Czech Academy of Sciences Publication Activity Database

    Buchta, Zdeněk; Šarbort, Martin; Řeřucha, Šimon; Hucl, Václav; Čížek, Martin; Lazar, Josef; Číp, Ondřej

    Bellingham : SPIE, 2014, 91321J:1-7. ISSN 0277-786X. [Optical Micro- and Nanometrology /5./. Brussels (BE), 15.04.2014-17.04.2014] R&D Projects: GA TA ČR(CZ) TA03010663; GA ČR GP102/09/P293; GA ČR GAP102/10/1813; GA MŠk ED0017/01/01; GA MŠk(CZ) LC06007; GA MŠk(CZ) LO1212 Institutional support: RVO:68081731 Keywords : low-coherence interferometry * gauge block * metrology Subject RIV: BH - Optics, Masers, Lasers

  8. Cooperative storage of shared files in a parallel computing system with dynamic block size

    Science.gov (United States)

    Bent, John M.; Faibish, Sorin; Grider, Gary

    2015-11-10

    Improved techniques are provided for parallel writing of data to a shared object in a parallel computing system. A method is provided for storing data generated by a plurality of parallel processes to a shared object in a parallel computing system. The method is performed by at least one of the processes and comprises: dynamically determining a block size for storing the data; exchanging a determined amount of the data with at least one additional process to achieve a block of the data having the dynamically determined block size; and writing the block of the data having the dynamically determined block size to a file system. The determined block size comprises, e.g., a total amount of the data to be stored divided by the number of parallel processes. The file system comprises, for example, a log structured virtual parallel file system, such as a Parallel Log-Structured File System (PLFS).

  9. Child Abuse Images and Cleanfeeds: Assessing Internet Blocking Systems

    OpenAIRE

    McIntyre, T. J.

    2013-01-01

    One of the most important trends in internet governance in recent years has been the growth of internet blocking as a policy tool, to the point where it is increasingly becoming a global norm. This is most obvious in states such as China where blocking is used to suppress political speech; however, in the last decade blocking has also become more common in democracies, usually as part of attempts to limit the availability of child abuse images. Numerous governments have therefore settled on b...

  10. The response of high-impact blocking weather systems to climate change

    Science.gov (United States)

    Kennedy, Daniel; Parker, Tess; Woollings, Tim; Harvey, Benjamin; Shaffrey, Len

    2016-07-01

    Midlatitude weather and climate are dominated by the jet streams and associated eastward moving storm systems. Occasionally, however, these are blocked by persistent anticyclonic regimes known as blocking. Climate models generally predict a small decline in blocking frequency under anthropogenic climate change. However, confidence in these predictions is undermined by, among other things, a lack of understanding of the physical mechanisms underlying the change. Here we analyze blocking (mostly in the Euro-Atlantic sector) in a set of sensitivity experiments to determine the effect of different parts of the surface global warming pattern. We also analyze projected changes in the impacts of blocking such as temperature extremes. The results show that enhanced warming both in the tropics and over the Arctic act to strengthen the projected decline in blocking. The tropical changes are more important for the uncertainty in projected blocking changes, though the Arctic also affects the temperature anomalies during blocking.

  11. The Ubiquitin System and Jasmonate Signaling

    Directory of Open Access Journals (Sweden)

    Astrid Nagels Durand

    2016-01-01

    Full Text Available The ubiquitin (Ub system is involved in most, if not all, biological processes in eukaryotes. The major specificity determinants of this system are the E3 ligases, which bind and ubiquitinate specific sets of proteins and are thereby responsible for target recruitment to the proteasome or other cellular processing machineries. The Ub system contributes to the regulation of the production, perception and signal transduction of plant hormones. Jasmonic acid (JA and its derivatives, known as jasmonates (JAs, act as signaling compounds regulating plant development and plant responses to various biotic and abiotic stress conditions. We provide here an overview of the current understanding of the Ub system involved in JA signaling.

  12. Block quasi-minimal residual iterations for non-Hermitian linear systems

    Energy Technology Data Exchange (ETDEWEB)

    Freund, R.W. [AT& T Bell Labs., Murray Hill, NJ (United States)

    1994-12-31

    Many applications require the solution of multiple linear systems that have the same coefficient matrix, but differ only in their right-hand sides. Instead of applying an iterative method to each of these systems individually, it is usually more efficient to employ a block version of the method that generates blocks of iterates for all the systems simultaneously. An example of such an iteration is the block conjugate gradient algorithm, which was first studied by Underwood and O`Leary. On parallel architectures, block versions of conjugate gradient-type methods are attractive even for the solution of single linear systems, since they have fewer synchronization points than the standard versions of these algorithms. In this talk, the author presents a block version of Freund and Nachtigal`s quasi-minimal residual (QMR) method for the iterative solution of non-Hermitian linear systems. He describes two different implementations of the block-QMR method, one based on a block version of the three-term Lanczos algorithm and one based on coupled two-term block recurrences. In both cases, the underlying block-Lanczos process still allows arbitrary normalizations of the vectors within each block, and the author discusses different normalization strategies. To maintain linear independence within each block, it is usually necessary to reduce the block size in the course of the iteration, and the author describes a deflation technique for performing this reduction. He also present some convergence results, and reports results of numerical experiments with the block-QMR method. Finally, the author discusses possible block versions of transpose-free Lanczos-based iterations such as the TFQMR method.

  13. Signaling via the NFκB system.

    Science.gov (United States)

    Mitchell, Simon; Vargas, Jesse; Hoffmann, Alexander

    2016-05-01

    The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune development, immune responses, inflammation, and cancer. The NFκB signaling system (defined by the interactions between NFκB dimers, IκB regulators, and IKK complexes) is responsive to a number of stimuli, and upon ligand-receptor engagement, distinct cellular outcomes, appropriate to the specific signal received, are set into motion. After almost three decades of study, many signaling mechanisms are well understood, rendering them amenable to mathematical modeling, which can reveal deeper insights about the regulatory design principles. While other reviews have focused on upstream, receptor proximal signaling (Hayden MS, Ghosh S. Signaling to NF-κB. Genes Dev 2004, 18:2195-2224; Verstrepen L, Bekaert T, Chau TL, Tavernier J, Chariot A, Beyaert R. TLR-4, IL-1R and TNF-R signaling to NF-κB: variations on a common theme. Cell Mol Life Sci 2008, 65:2964-2978), and advances through computational modeling (Basak S, Behar M, Hoffmann A. Lessons from mathematically modeling the NF-κB pathway. Immunol Rev 2012, 246:221-238; Williams R, Timmis J, Qwarnstrom E. Computational models of the NF-KB signalling pathway. Computation 2014, 2:131), in this review we aim to summarize the current understanding of the NFκB signaling system itself, the molecular mechanisms, and systems properties that are key to its diverse biological functions, and we discuss remaining questions in the field. WIREs Syst Biol Med 2016, 8:227-241. doi: 10.1002/wsbm.1331 For further resources related to this article, please visit the WIREs website. PMID:26990581

  14. Morbillivirus V Proteins Exhibit Multiple Mechanisms to Block Type 1 and Type 2 Interferon Signalling Pathways

    OpenAIRE

    Chinnakannan, Senthil K.; Nanda, Sambit K.; Baron, Michael D.

    2013-01-01

    Morbilliviruses form a closely related group of pathogenic viruses which encode three non-structural proteins V, W and C in their P gene. Previous studies with rinderpest virus (RPV) and measles virus (MeV) have demonstrated that these non-structural proteins play a crucial role in blocking type I (IFNα/β) and type II (IFNγ) interferon action, and various mechanisms have been proposed for these effects. We have directly compared four important morbilliviruses, rinderpest (RPV), measles virus ...

  15. Prediction of Wintertime Northern Hemisphere Blocking by the NCEP Climate Forecast System

    Institute of Scientific and Technical Information of China (English)

    JIA Xiaolong; YANG Song; SONG Wenling; HE Bin

    2014-01-01

    Daily output from the hindcasts by the NCEP Climate Forecast System version 2 (CFSv2) is analyzed to understand CFSv2’s skill in forecasting wintertime atmospheric blocking in the Northern Hemisphere. Prediction skills of sector blocking, sector-blocking episodes, and blocking onset/decay are assessed with a focus on the Euro-Atlantic sector (20◦W-45◦E) and the Pacifi c sector (160◦E-135◦W). Features of associated circulation and climate patterns are also examined. The CFSv2 well captures the observed features of longitudinal distribution of blocking activity, but underestimates blocking frequency and intensity and shows a decreasing trend in blocking frequency with increasing forecast lead time. Within 14-day lead time, the Euro-Atlantic sector blocking receives a higher skill than the Pacifi c sector blocking. Skillful forecast (taking the hit rate of 50% as a criterion) can be obtained up to 9 days in the Euro-Atlantic sector, which is slightly longer than that in the Pacifi c sector (7 days). The forecast skill of sector-blocking episodes is slightly lower than that of sector blocking in both sectors, and it is slightly higher in the Euro-Atlantic sector than in the Pacifi c sector. Compared to block onset, the skill for block decay is lower in the Euro-Atlantic sector, slightly higher in the Pacifi c sector during the early three days but lower after three days in lead time. In both the Euro-Atlantic and the Pacifi c sectors, a local dipole pattern in 500-hPa geopotential height associated with blocking is well presented in the CFSv2 prediction, but the wave-train like pattern that is far away from the blocking sector can only maintain in the forecast of relative short lead time. The CFSv2 well reproduces the observed characteristics of local temperature and precipitation anomalies associated with blocking.

  16. Traffic Signal Using Smart Agent System

    Directory of Open Access Journals (Sweden)

    Cheonshik Kim

    2008-01-01

    Full Text Available In this research, we propose an electro-sensitive traffic light using the smart agent algorithm to reduce traffic congestion and traffic accidents. The multi-agent system approach can provide a new and preferable solution. The proposed method adaptively controls the cycle of traffic signals even though the traffic volume varies. Consequently, we reduce the car waiting time and start-up delay time using fuzzy control of feedback data. In particular, we have designed and implemented a system to create optimum traffic signals in congested conditions. The effectiveness of this method was shown through simulation of multiple intersections.

  17. Systems and signal processing in nuclear medicine

    International Nuclear Information System (INIS)

    Proceedings covering all lectures presented to the 7th Spring Meeting of Deutsche Gesellschaft fuer Med. Dokumentation, Informatik und Statistik, GMDS, on the subject of ''Systems and signal processing in nuclear medicine''. Currently available systems for nuclear medicine and their application in administration, documentation and clinical routine examinations are dealt with in the first part. Three papers discuss various methods of signal processing, and methods of automatic image processing are dealt with at length. Trends of development are discussed, and the situation of nuclear medicine in various European countries is reviewed. (WU)

  18. Irregular blocks, N = 2 gauge theory and Mathieu system

    Science.gov (United States)

    Piatek, M. R.; Pietrykowski, A. R.

    2016-01-01

    The Alday-Gayotto-Tachikawa (AGT) conjecture relates 4d N = 2, SU(2) SYM theories with Nf matter hypermultiplets to 2d CFT. In case of pure 4d N = 2, SU(2) SYM there is a corresponding irregular conformal block in 2d CFT. The AGT correspondence may be extended within a certain limit (the Nekrasov-Shataschvili limit) to the correspondence between an effective twisted superpotentials of 2d N = 2 SUSY and the Zamolodchikov's “classical” conformal blocks. When narrowed to the pure 4d N = 2 SYM case its limit is related to an irregular classical conformal block. It will be shown that according to the triple correspondence (2dCFT/Gauge/Bethe - c.f. Piatek's talk) the irregular classical conformal block yields spectrum of Mathieu operator. The latter can be obtained as a “classical” limit of the null vector decoupling equation for three-point degenerate irregular block. It will also be shown that the Mathieu spectrum can be also obtained from the limit of the pure gauge theory as a solution of the saddle point equation as well as from the Bohr-Sommerfeld quantization of the Seiberg-Witten theory.

  19. Power systems signal processing for smart grids

    CERN Document Server

    Ribeiro, Paulo Fernando; Ribeiro, Paulo Márcio; Cerqueira, Augusto Santiago

    2013-01-01

    With special relation to smart grids, this book provides clear and comprehensive explanation of how Digital Signal Processing (DSP) and Computational Intelligence (CI) techniques can be applied to solve problems in the power system. Its unique coverage bridges the gap between DSP, electrical power and energy engineering systems, showing many different techniques applied to typical and expected system conditions with practical power system examples. Surveying all recent advances on DSP for power systems, this book enables engineers and researchers to understand the current state of the art a

  20. 75 FR 5638 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System...

    Science.gov (United States)

    2010-02-03

    ... discontinuance and removal of the Automatic Block Signal System (ABS) on the entire railroad line between, but... the Federal Register published on April 11, 2000 (65 FR 19477) or at http://www.dot.gov/privacy.html... Railroad Signal System or Relief From the Requirements of Title 49 Code of Federal Regulations Part...

  1. The V protein of Tioman virus is incapable of blocking type I interferon signaling in human cells.

    Directory of Open Access Journals (Sweden)

    Grégory Caignard

    Full Text Available The capacity of a virus to cross species barriers is determined by the development of bona fide interactions with cellular components of new hosts, and in particular its ability to block IFN-α/β antiviral signaling. Tioman virus (TioV, a close relative of mumps virus (MuV, has been isolated in giant fruit bats in Southeast Asia. Nipah and Hendra viruses, which are present in the same bat colonies, are highly pathogenic in human. Despite serological evidences of close contacts between TioV and human populations, whether TioV is associated to some human pathology remains undetermined. Here we show that in contrast to the V protein of MuV, the V protein of TioV (TioV-V hardly interacts with human STAT2, does not degrade STAT1, and cannot block IFN-α/β signaling in human cells. In contrast, TioV-V properly binds to human STAT3 and MDA5, and thus interferes with IL-6 signaling and IFN-β promoter induction in human cells. Because STAT2 binding was previously identified as a host restriction factor for some Paramyxoviridae, we established STAT2 sequence from giant fruit bats, and binding to TioV-V was tested. Surprisingly, TioV-V interaction with STAT2 from giant fruit bats is also extremely weak and barely detectable. Altogether, our observations question the capacity of TioV to appropriately control IFN-α/β signaling in both human and giant fruit bats that are considered as its natural host.

  2. Optimization of systems for interperiod signal processing

    OpenAIRE

    Popov, Dmitriy I.

    2014-01-01

    The optimization methods based on the probabilistic criterion of systems for interperiod signal processing have been considered. The specified methods perform coherent rejection of passive interferences (clutter) with subsequent coherent or incoherent accumulation of rejection residues. Adaptation principles of recursive rejection filters with a priori uncertainty of correlation characteristics of clutter were proposed. The efficiency analysis of adaptive rejection filters depending on the es...

  3. THEORETICAL PRINCIPLES OF ANTI-BLOCKING AND ANTI-SLIPPAGE SYSTEMS OF NEW GENERATION

    Directory of Open Access Journals (Sweden)

    N. N. Hurski

    2014-12-01

    Full Text Available A new approach on creation of anti-blocking and anti-slippage systems of mobile machines based on observation of actual forces/moment values in «road-wheel-car» contact and their derivatives is considered in the given paper. The paper describes theoretical principles and an operational algorithm of anti-blocking and anti-slippage systems.

  4. Haptic teleoperation systems signal processing perspective

    CERN Document Server

    Lee, Jae-young

    2015-01-01

    This book examines the signal processing perspective in haptic teleoperation systems. This text covers the topics of prediction, estimation, architecture, data compression, and error correction that can be applied to haptic teleoperation systems. The authors begin with an overview of haptic teleoperation systems, then look at a Bayesian approach to haptic teleoperation systems. They move onto a discussion of haptic data compression, haptic data digitization and forward error correction.   ·         Presents haptic data prediction/estimation methods that compensate for unreliable networks   ·         Discusses haptic data compression that reduces haptic data size over limited network bandwidth and haptic data error correction that compensate for packet loss problem   ·         Provides signal processing techniques used with existing control architectures.

  5. Bidirectional coupling of splicing and ATM signaling in response to transcription-blocking DNA damage

    NARCIS (Netherlands)

    M. Tresini (Maria); J.A. Marteijn (Jurgen); W. Vermeulen (Wim)

    2016-01-01

    textabstractIn response to DNA damage cells activate intricate protein networks to ensure genomic fidelity and tissue homeostasis. DNA damage response signaling pathways coordinate these networks and determine cellular fates, in part, by modulating RNA metabolism. Here we discuss a replication-indep

  6. Traffic Signal Using Smart Agent System

    OpenAIRE

    Cheonshik Kim; You S. Hong

    2008-01-01

    In this research, we propose an electro-sensitive traffic light using the smart agent algorithm to reduce traffic congestion and traffic accidents. The multi-agent system approach can provide a new and preferable solution. The proposed method adaptively controls the cycle of traffic signals even though the traffic volume varies. Consequently, we reduce the car waiting time and start-up delay time using fuzzy control of feedback data. In particular, we have designed and implemented a system to...

  7. Enhanced upper genital tract pathologies by blocking Tim-3 and PD-L1 signaling pathways in mice intravaginally infected with Chlamydia muridarum

    Directory of Open Access Journals (Sweden)

    Peng Bo

    2011-12-01

    Full Text Available Abstract Background Although Tim-3 & PD-L1 signaling pathways play important roles in negatively regulating immune responses, their roles in chlamydial infection have not been evaluated. Methods Neutralization antibodies targeting Tim-3 and PD-L1 were used to treat mice. Following an intravaginal infection with C. muridarum organisms, mice with or without the dual antibody treatment were compared for live chlamydial organism shedding from the lower genital tract and inflammatory pathology in the upper genital tract. Results Mice treated with anti-Tim-3 and anti-PD-L1 antibodies displayed a time course of live organism shedding similar to that of mice treated with equivalent amounts of isotype-matched IgG molecules. The combined antibody blocking failed to alter either the lower genital tract cytokine or systemic humoral and cellular adaptive responses to C. muridarum infection. However, the antibody blocking significantly enhanced C. muridarum-induced pathologies in the upper genital tract, including more significant hydrosalpinx and inflammatory infiltration in uterine horn and oviduct tissues. Conclusions The Tim-3 and PD-L1-mediated signaling can significantly reduce pathologies in the upper genital tract without suppressing immunity against chlamydial infection, suggesting that Tim-3 and PD-L1-mediated negative regulation may be manipulated to attenuate tubal pathologies in women persistently infected with C. trachomatis organisms.

  8. Block Two-stage Methods for Singular Systems and Markov Chains

    OpenAIRE

    Migallón Gomis, Violeta; Penadés, Jose; Szyld, Daniel B.

    2007-01-01

    Research Report 95-121, Department of Mathematics, Temple University, December 1995. This paper appeared, in revised form, in Numerical Linear Algebra with Applications, vol. 3 (1996) 413-426. The use of block two-stage methods for the iterative solution of consistent singular linear systems is studied. In particular, hypotheses are provided for the convergence of non-stationary methods, i.e., when the number of inner iterations may vary from block to block and from one outer iteration to ...

  9. DESIGN PRINCIPLES AND BLOCK SCHEMES OF THE PROBE AUTOMATIC INSPECTION SYSTEMS FOR MICROAND NANOELECTRONICS ON A WAFER

    Directory of Open Access Journals (Sweden)

    V. A. Minchenko

    2012-01-01

    Full Text Available In this work we suggested the principles of design and block schemes of probe systems for analytical and interoperation measurement and inspection of high-speed microand nano on a chip systems in the nanosecond range. The sources of wideband signals distortion and errors of probe inspection systems for large integrated circuits inspection as well as transient response of high speed contacting probes are considered with the OTDR device with picosecond resolution. The features and defined errors of precision positioners for linear stepper motors and magnetic air motors for precise positioning of the probes on the pads with automatic sensing of LSI wafer are discussed. 

  10. Inhibition of Tankyrases Induces Axin Stabilization and Blocks Wnt Signalling in Breast Cancer Cells

    OpenAIRE

    Bao, Renyue; Christova, Tania; Song, Siyuan; Angers, Stephane; Yan, Xiaojun; Attisano, Liliana

    2012-01-01

    Constitutive Wnt signalling is characterized by excessive levels of β-catenin protein and is a frequent occurrence in cancer. APC and Axin are key components of the β-catenin destruction complex that acts to promote β-catenin degradation. The levels of Axin are in turn controlled by tankyrases, members of the PARP-family of poly-ADP-ribosylation enzymes. In colorectal cancer cells, which typically harbor APC mutations, inhibition of tankyrase activity promotes Axin stabilization and attenuate...

  11. Flash memory management system and method utilizing multiple block list windows

    Science.gov (United States)

    Chow, James (Inventor); Gender, Thomas K. (Inventor)

    2005-01-01

    The present invention provides a flash memory management system and method with increased performance. The flash memory management system provides the ability to efficiently manage and allocate flash memory use in a way that improves reliability and longevity, while maintaining good performance levels. The flash memory management system includes a free block mechanism, a disk maintenance mechanism, and a bad block detection mechanism. The free block mechanism provides efficient sorting of free blocks to facilitate selecting low use blocks for writing. The disk maintenance mechanism provides for the ability to efficiently clean flash memory blocks during processor idle times. The bad block detection mechanism provides the ability to better detect when a block of flash memory is likely to go bad. The flash status mechanism stores information in fast access memory that describes the content and status of the data in the flash disk. The new bank detection mechanism provides the ability to automatically detect when new banks of flash memory are added to the system. Together, these mechanisms provide a flash memory management system that can improve the operational efficiency of systems that utilize flash memory.

  12. Dealing naturally with stumbling blocks on highways and byways of TRAIL induced signaling.

    Science.gov (United States)

    Rana, Aamir; Attar, Rukset; Qureshi, Muhammad Zahid; Gasparri, Maria Luisa; Donato, Violante Di; Ali, Ghulam Muhammad; Farooqi, Ammad Ahmad

    2014-01-01

    In-depth analysis of how TRAIL signals through death receptors to induce apoptosis in cancer cells using high throughput technologies has added new layers of knowledge. However, the wealth of information has also highlighted the fact that TRAIL induced apoptosis may be impaired as evidenced by experimental findings obtained from TRAIL resistant cancer cell lines. Overwhelmingly, increasing understanding of TRAIL mediated apoptosis has helped in identifying synthetic and natural compounds which can restore TRAIL induced apoptosis via functionalization of either extrinsic or intrinsic pathways. Increasingly it is being realized that biologically active phytochemicals modulate TRAIL induced apoptosis, as evidenced by cell-based studies. In this review we have attempted to provide an overview of how different phytonutrients have shown efficacy in restoring apoptosis in TRAIL resistant cancer cells. We partition this review into how the TRAIL mediated signaling landscape has broadened over the years and how TRAIL induced signaling machinery crosstalks with autophagic protein networks. Subsequently, we provide a generalized view of considerable biological activity of coumarins against a wide range of cancer cell lines and how coumarins (psoralidin and esculetin) isolated from natural sources have improved TRAIL induced apoptosis in resistant cancer cells. We summarize recent updates on piperlongumine, phenethyl isothiocyanate and luteolin induced activation of TRAIL mediated apoptosis. The data obtained from pre-clinical studies will be helpful in translation of information from benchtop to the bedside. PMID:25338981

  13. Drugs to block cytokine signaling for the prevention and treatment of inflammation induced preterm birth

    Directory of Open Access Journals (Sweden)

    Pearl Y Ng

    2015-04-01

    Full Text Available Preterm birth (PTB at less than 37 weeks of gestation is the leading cause of neonatal morbidity and mortality. Intrauterine infection (IUI due to microbial invasion of the amniotic cavity is the leading cause of early PTB (<32 weeks. Commensal genital tract Ureaplasma and Mycoplasma species, as well as Gram-positive and Gram-negative bacteria, have been associated with IUI-induced PTB. Bacterial activation of toll-like receptors (TLRs and other pattern recognition receptors initiates a cascade of inflammatory signaling via the NF-κB and p38 MAPK signaling pathways, prematurely activating parturition. Antenatal antibiotic treatment has had limited success in preventing PTB or fetal inflammation. Administration of anti-inflammatory drugs with antibiotics could be a viable therapeutic option to prevent PTB and fetal complications in women at risk of IUI and inflammation. In this mini-review we will discuss the potential for anti-inflammatory drugs in obstetric care, focusing on the class of drugs termed ‘cytokine suppressive anti-inflammatory drugs’ or CSAIDs. These inhibitors work by specifically targeting the NF-κB and p38 MAPK inflammatory signaling pathways. Several CSAIDs are discussed, together with clinical and toxicological considerations associated with the administration of anti-inflammatory agents in pregnancy.

  14. Spatial Organization of Cytokinesis Signaling Reconstituted in a Cell-Free System*

    OpenAIRE

    Nguyen, Phuong A.; Groen, Aaron C.; Loose, Martin; Ishihara, Keisuke; Wühr, Martin; Field, Christine M.; Mitchison, Timothy J.

    2014-01-01

    During animal cell division, the cleavage furrow is positioned by microtubules that signal to the actin cortex at the cell midplane. We developed a cell-free system to recapitulate cytokinesis signaling using cytoplasmic extract from Xenopus eggs. Microtubules grew out as asters from artificial centrosomes and met to organize antiparallel overlap zones. These zones blocked interpenetration of neighboring asters and recruited cytokinesis midzone proteins including the Chromosoma...

  15. Antenna Array Signal Processing for Quaternion-Valued Wireless Communication Systems

    OpenAIRE

    Liu, W.

    2015-01-01

    Quaternion-valued wireless communication systems have been studied in the past. Although progress has been made in this promising area, a crucial missing link is lack of effective and efficient quaternion-valued signal processing algorithms for channel equalisation and beamforming. With most recent developments in quaternion-valued signal processing, in this work, we fill the gap to solve the problem and further derive the quaternion-valued Wiener solution for block-based calculation.

  16. Fully automatic optical system for gauge block calibration

    Czech Academy of Sciences Publication Activity Database

    Buchta, Zdeněk; Šarbort, Martin; Řeřucha, Šimon; Čížek, Martin; Hucl, Václav; Lazar, Josef; Číp, Ondřej

    Erlangen : DGaO, 2015. s. 98-99. [Annual Meeting of the DGaO /116./. 26.05.2015-29.05.2015, Brno] R&D Projects: GA TA ČR(CZ) TA03010663; GA MŠk(CZ) LO1212; GA MŠk ED0017/01/01 Institutional support: RVO:68081731 Keywords : industrial metrology * guague block * interferometry Subject RIV: BH - Optics, Masers, Laser s

  17. Reticuloendothelial system blocking with gamma globulins makes radioimmunotargetting more efficient

    International Nuclear Information System (INIS)

    Introduction: Currently there are three principal Methods of treating cancer viz. Surgery, Chemotherapy and External radiation therapy. Each of these has its limitations. There is much interest today in the development of a new mode of therapy viz. the administration of radio labelled bi, conjugates in nuclear medicine for the selective delivery of radiation to the cancer cells while sparing the normal cells. Radioimmunotargetting is analogous to radio war-head being carried by a guided missile or smart bomb (the bi,conjugates) which selectively homes on the cancer cells by specific recognition of molecules on the cancer cell surface. One of the major problems limiting radiobioconjugate therapy is the small fraction of the injected dose of radiolabelled biomotecules that goes to specific tumour sites. In the case of' Radioimmunotherapy with radiolabelled antibodies, large amount of these radiolabelled antibodies is wasted by nonspecific targets in the reticuloendothelial system (RES) believed to be mediated through their Fc moieties tinldng to galactosyl receptors. Apart from the use of constructs devoid of Fc or degalactosylation of the antibodies, RES blocking is a method of enhancing target/nontarget ratios. We describe our findings on a novel approach: bloctdng the RES by prior administration of large molecular weight agents. Materials and methods: In experimental Nude/Swiss albino mice, five agents viz. India Ink, Human gammaglobulin, Dextran, Polygeline and hydroxyethyt starch were evaluated for their ability to decrease this nonspecific uptake in both nontumour bearing animals and Human turn,ur xenografted animals. These were administered in quantities of 1 mg intravenously in the tail vein 4 or 24 hours prior to the injection of 50 ug of radiotabetled human immunogiobutin or radiotabetled M3 antibody. The antibodies were labelled with Technetium 99m, Iodine 131 or Gold 199. The bi,distribution of the radiopharmaceutical was followed by serial scans using a

  18. Description on the signal processing system of ATLAS facility

    International Nuclear Information System (INIS)

    In the present report, signal processing system and logic of ATLAS facility was explained. Input signals was categorized as the first-, second- and third-order EU (engineering unit) parameter according to the signal processing logic. The system integration was described in Chapter 2, and the signal process logic of different types of signals was presented in Chapter 3

  19. Norcantharidin blocks Wnt/β-catenin signaling via promoter demethylation of WIF-1 in glioma.

    Science.gov (United States)

    Xie, Dajiang; Xie, Jixi; Wan, Yingfeng; Ma, Li; Qi, Xuchen; Wang, Kun; Yang, Shuxu

    2016-04-01

    Glioma is one of the most common primary intracranial tumors, and the prognosis is poor even though much treatment management is employed. Wnt/β-catenin signaling has been reported to be associated with glioma. Norcantharidin (NCTD) is the demethylated analog of cantharidin isolated from blister beetles, and it is reported to possess anticancer activity but less nephrotoxicity than cantharidin. Accordingly, we aimed to investigate NCTD as an anti-neoplastic drug that inhibits the Wnt/β‑catenin pathway via promoter demethylation of Wnt inhibitory factor-1 (WIF-1) in glioma growth in vitro. In the present study, we report that NCTD inhibited cell proliferation, induced apoptosis and cell cycle arrest, and suppressed cell migration and invasion in vitro. Moreover, we observed that the expression levels of WIF-1 mRNA and protein in the NCTD-treated cells were increased significantly compared with these levels in the negative control (NC) cells. Promoter demethylation was observed in the NCTD‑treated cells. In contrast, aberrant methylation was observed in the NC cells. Additionally, more investigation revealed that NCTD suppressed activity of Wnt/β-catenin signaling and transcription of β-catenin/TCF-4. Furthermore, the expression of apoptosis-related proteins Bcl-2 and cleaved caspase-3 indicated significant cell apoptosis. We provide initial evidence that NCTD reactivates WIF-1 from a methylation state, and downregulates canonical Wnt/β-catenin signaling. Our findings revealed that NCTD is effective for glioma in vitro and may be a new therapeutic option in vivo. PMID:26781164

  20. Blocking lhh Signaling Pathway Inhibits the Proliferation and Pro-motes the Apoptosis of PSCs

    Institute of Scientific and Technical Information of China (English)

    Kai XU; Fengjing GUO; Shuwei ZHANG; Cheng LIU; Feixiong WANG; Zhiguo ZHOU; Anmin CHEN

    2009-01-01

    The roles of Indian hedgehog (Ihh) signaling pathway in the proliferation and apoptosis of precartilaginous stem cells (PSCs) were investigated.PSCs,labeled with fibroblast growth factor receptor 3 (FGFR-3),were isolated from neonatal rats by immanomagnetic separation.After identifi-cation with FGFR-3 and Col Ⅱ,the cells were incubated with different concentrations of cyclopamine (cyclo),the specific inhibitor of lhh signaling pathway.The morphologic changes of the cells were observed under the inverted phase contrast microscope.The mRNA expression levels of Ibh,para-thyroid hormonerelated peptide (PTHrP),protein Patched (Ptch),Bcl-2 and p21 were detected by RT-PCR.The protein expression levels of Ihh and Ptch were measured by Western blot.MTT assay was used to examine the effects of cyclo on proliferation of PSCs.Apoptosis rate of PSCs was exam-ined by Annexin V/PI assay of flow cytometric analyses.After PSCs were incubated with cyclo,ob-vious morphologic changes were observed as compared with the control group.The mRNA expres-sion levels of PTHrP,Ptch and Bcl-2 were decreased to varying degrees in a cyclo dose-dependent manner.However,the expression levels of lhh and p21 mRNA were increased.The protein expres-sion of Ptch and Ihh had the same change as the mRNA expression.Meanwhile,cyclo could obvi-ously inhibit the proliferation and promote the apoptosis of PSCs.The results indicated that Ihh sig-naling pathway plays an important role in regulating the proliferation and apoptosis of PSCs,which is probably mediated by Bcl-2 and p21.

  1. Hepatitis B virus polymerase blocks pattern recognition receptor signaling via interaction with DDX3: implications for immune evasion.

    Directory of Open Access Journals (Sweden)

    Haifeng Wang

    Full Text Available Viral infection leads to induction of pattern-recognition receptor signaling, which leads to interferon regulatory factor (IRF activation and ultimately interferon (IFN production. To establish infection, many viruses have strategies to evade the innate immunity. For the hepatitis B virus (HBV, which causes chronic infection in the liver, the evasion strategy remains uncertain. We now show that HBV polymerase (Pol blocks IRF signaling, indicating that HBV Pol is the viral molecule that effectively counteracts host innate immune response. In particular, HBV Pol inhibits TANK-binding kinase 1 (TBK1/IkappaB kinase-epsilon (IKKepsilon, the effector kinases of IRF signaling. Intriguingly, HBV Pol inhibits TBK1/IKKepsilon activity by disrupting the interaction between IKKepsilon and DDX3 DEAD box RNA helicase, which was recently shown to augment TBK1/IKKepsilon activity. This unexpected role of HBV Pol may explain how HBV evades innate immune response in the early phase of the infection. A therapeutic implication of this work is that a strategy to interfere with the HBV Pol-DDX3 interaction might lead to the resolution of life-long persistent infection.

  2. PRECISE SYNTHESIS OF OLEFIN BLOCK COPOLYMERS USING A SYNDIOSPECIFIC LIVING POLYMERIZATION SYSTEM

    Institute of Scientific and Technical Information of China (English)

    Zheng-guo Cai; Hai-hui Su; Takeshi Shiono

    2013-01-01

    This feature article summarizes the synthesis of novel olefin block copolymers using fast syndiospecific living homo-and copolymerization of propylene,higher 1-alkene,and norbomene with ansa-fluorenylamidodimethyltitaniumbased catalyst according to the authors' recent results.The catalytic synthesis of monodisperse polyolefin and olefin block copolymer was also described using this living system.

  3. Blocking transforming growth factor- receptor signaling down-regulates transforming growth factor-β1 autoproduction in keloid fibroblasts

    Institute of Scientific and Technical Information of China (English)

    刘伟; 蔡泽浩; 王丹茹; 武小莉; 崔磊; 商庆新; 钱云良; 曹谊林

    2002-01-01

    Objective: To study transforming growth factor-β1(TGF-β1) autoproduction in keloid fibroblasts and theregulation effect of blocking TGF-β intracellular signalingon rhTGF-β1 autoproduction.Methods: Keloid fibroblasts cultured in vitro weretreated with either rhTGF-β1 (5 ng/ml ) or recombinantadenovirus containing a truncated type II TGF-β receptorgene (50 pfu/cell ). Their effects of regulating geneexpression of TGF-β1 and its receptor I and II wereobserved with Northern blot.Results: rhTGF-β1 up-regulated the gene expressionof TGF-β1 and receptor I, but not receptor II. Over-expression of the truncated receptor II down-regulated thegene expression of TGF-β1 and its receptor I, but notreceptor II.Conclusions: TGF-β1 autoproduction was observed inkeloid fibroblasts. Over-expression of the truncated TGF-βreceptor H decreased TGF-β1 autoproduction via blockingTGF-β receptor signaling.

  4. Suramin blocks interaction between human FGF1 and FGFR2 D2 domain and reduces downstream signaling activity.

    Science.gov (United States)

    Wu, Zong-Sian; Liu, Che Fu; Fu, Brian; Chou, Ruey-Hwang; Yu, Chin

    2016-09-01

    The extracellular portion of the human fibroblast growth factor receptor2 D2 domain (FGFR2 D2) interacts with human fibroblast growth factor 1 (hFGF1) to activate a downstream signaling cascade that ultimately affects mitosis and differentiation. Suramin is an antiparasiticdrug and a potent inhibitor of FGF-induced angiogenesis. Suramin has been shown to bind to hFGF1, and might block the interaction between hFGF1 and FGFR2 D2. Here, we titrated hFGF1 with FGFR2 D2 and suramin to elucidate their interactions using the detection of NMR. The docking results of both hFGF1-FGFR2 D2 domain and hFGF1-suramin complex were superimposed. The results indicate that suramin blocks the interaction between hFGF1 and FGFR2 D2. We used the PyMOL software to show the hydrophobic interaction of hFGF1-suramin. In addition, we used a Water-soluble Tetrazolium salts assay (WST1) to assess hFGF1 bioactivity. The results will be useful for the development of new antimitogenic activity drugs. PMID:27387234

  5. SiC Multi-Chip Power Modules as Power-System Building Blocks

    Science.gov (United States)

    Lostetter, Alexander; Franks, Steven

    2007-01-01

    The term "SiC MCPMs" (wherein "MCPM" signifies "multi-chip power module") denotes electronic power-supply modules containing multiple silicon carbide power devices and silicon-on-insulator (SOI) control integrated-circuit chips. SiC MCPMs are being developed as building blocks of advanced expandable, reconfigurable, fault-tolerant power-supply systems. Exploiting the ability of SiC semiconductor devices to operate at temperatures, breakdown voltages, and current densities significantly greater than those of conventional Si devices, the designs of SiC MCPMs and of systems comprising multiple SiC MCPMs are expected to afford a greater degree of miniaturization through stacking of modules with reduced requirements for heat sinking. Moreover, the higher-temperature capabilities of SiC MCPMs could enable operation in environments hotter than Si-based power systems can withstand. The stacked SiC MCPMs in a given system can be electrically connected in series, parallel, or a series/parallel combination to increase the overall power-handling capability of the system. In addition to power connections, the modules have communication connections. The SOI controllers in the modules communicate with each other as nodes of a decentralized control network, in which no single controller exerts overall command of the system. Control functions effected via the network include synchronization of switching of power devices and rapid reconfiguration of power connections to enable the power system to continue to supply power to a load in the event of failure of one of the modules. In addition to serving as building blocks of reliable power-supply systems, SiC MCPMs could be augmented with external control circuitry to make them perform additional power-handling functions as needed for specific applications: typical functions could include regulating voltages, storing energy, and driving motors. Because identical SiC MCPM building blocks could be utilized in a variety of ways, the cost

  6. Signals and Systems in Biomedical Engineering Signal Processing and Physiological Systems Modeling

    CERN Document Server

    Devasahayam, Suresh R

    2013-01-01

    The use of digital signal processing is ubiquitous in the field of physiology and biomedical engineering. The application of such mathematical and computational tools requires a formal or explicit understanding of physiology. Formal models and analytical techniques are interlinked in physiology as in any other field. This book takes a unitary approach to physiological systems, beginning with signal measurement and acquisition, followed by signal processing, linear systems modelling, and computer simulations. The signal processing techniques range across filtering, spectral analysis and wavelet analysis. Emphasis is placed on fundamental understanding of the concepts as well as solving numerical problems. Graphs and analogies are used extensively to supplement the mathematics. Detailed models of nerve and muscle at the cellular and systemic levels provide examples for the mathematical methods and computer simulations. Several of the models are sufficiently sophisticated to be of value in understanding real wor...

  7. System for Detection of Vital Signals with an Embedded System

    OpenAIRE

    chetty, maheswari arumugam

    2011-01-01

    Rapid advancement in the field of Embedded Systems and Wireless communications has permitted development of Revolutionary Medical Monitoring Systems and thus improving the lifestyle of patients. The system captures and analyzes the ECG signals in real time through a low cost embedded development board. The system can detect cardiac abnormalities with high precision. One of the objectives at the time of building the proposed system has been to optimize the resources, memory size and communicat...

  8. Geomorphic signal of active faulting at the northern edge of Lut Block: Insights on the kinematic scenario of Central Iran

    Science.gov (United States)

    Calzolari, Gabriele; Della Seta, Marta; Rossetti, Federico; Nozaem, Reza; Vignaroli, Gianluca; Cosentino, Domenico; Faccenna, Claudio

    2016-01-01

    Recent works documented Neogene to Quaternary dextral strike-slip tectonics along the Kuh-e-Sarhangi and Kuh-e-Faghan intraplate strike-slip faults at the northern edge of the Lut Block of Central Iran, previously thought to be dominated by sinistral strike-slip deformation. This work focuses on the evidence of Quaternary activity of one of these fault systems, in order to provide new spatiotemporal constraints on their role in the active regional kinematic scenario. Through geomorphological and structural investigation, integrated with optically stimulated luminescence dating of three generations of alluvial fans and fluvial terraces (at ~53, ~25, and ~6 ka), this study documents (i) the topographic inheritance of the long-term (Myr) punctuated history of fault nucleation, propagation, and exhumation along the northern edge of Lut Block; (ii) the tectonic control on drainage network evolution, pediment formation, fluvial terraces, and alluvial fan architecture; (iii) the minimum Holocene age of Quaternary dextral strike-slip faulting; and (iv) the evidence of Late Quaternary fault-related uplift localized along the different fault strands. The documented spatial and temporal constraints on the active dextral strike-slip tectonics at the northern edge of Lut Block provide new insights on the kinematic model for active faulting in Central Iran, which has been reinterpreted in an escape tectonic scenario.

  9. Tracing the Archaeal Origins of Eukaryotic Membrane-Trafficking System Building Blocks.

    Science.gov (United States)

    Klinger, Christen M; Spang, Anja; Dacks, Joel B; Ettema, Thijs J G

    2016-06-01

    In contrast to prokaryotes, eukaryotic cells are characterized by a complex set of internal membrane-bound compartments. A subset of these, and the protein machineries that move material between them, define the membrane-trafficking system (MTS), the emergence of which represents a landmark in eukaryotic evolution. Unlike mitochondria and plastids, MTS organelles have autogenous origins. Much of the MTS machinery is composed of building blocks, including small GTPase, coiled-coil, beta-propeller + alpha-solenoid, and longin domains. Despite the identification of prokaryotic proteins containing these domains, only few represent direct orthologues, leaving the origins and early evolution of the MTS poorly understood. Here, we present an in-depth analysis of MTS building block homologues in the composite genome of Lokiarchaeum, the recently discovered archaeal sister clade of eukaryotes, yielding several key insights. We identify two previously unreported Eukaryotic Signature Proteins; orthologues of the Gtr/Rag family GTPases, involved in target of rapamycin complex signaling, and of the RLC7 dynein component. We could not identify golgin or SNARE (coiled-coil) or beta-propeller + alpha-solenoid orthologues, nor typical MTS domain fusions, suggesting that these either were lost from Lokiarchaeum or emerged later in eukaryotic evolution. Furthermore, our phylogenetic analyses of lokiarchaeal GTPases support a split into Ras-like and Arf-like superfamilies, with different prokaryotic antecedents, before the advent of eukaryotes. While no GTPase activating proteins or exchange factors were identified, we show that Lokiarchaeum encodes numerous roadblock domain proteins and putative longin domain proteins, confirming the latter's origin from Archaea. Altogether, our study provides new insights into the emergence and early evolution of the eukaryotic membrane-trafficking system. PMID:26893300

  10. Enhancement of Secrecy of Block Ciphered Systems by Deliberate Noise

    CERN Document Server

    Khiabani, Yahya S; Yuan, Jian; Wang, Jian

    2012-01-01

    This paper considers the problem of end-end security enhancement by resorting to deliberate noise injected in ciphertexts. The main goal is to generate a degraded wiretap channel in application layer over which Wyner-type secrecy encoding is invoked to deliver additional secure information. More specifically, we study secrecy enhancement of DES block cipher working in cipher feedback model (CFB) when adjustable and intentional noise is introduced into encrypted data in application layer. A verification strategy in exhaustive search step of linear attack is designed to allow Eve to mount a successful attack in the noisy environment. Thus, a controllable wiretap channel is created over multiple frames by taking advantage of errors in Eve's cryptanalysis, whose secrecy capacity is found for the case of known channel states at receivers. As a result, additional secure information can be delivered by performing Wyner type secrecy encoding over super-frames ahead of encryption, namely, our proposed secrecy encoding...

  11. Efficient audio signal processing for embedded systems

    Science.gov (United States)

    Chiu, Leung Kin

    As mobile platforms continue to pack on more computational power, electronics manufacturers start to differentiate their products by enhancing the audio features. However, consumers also demand smaller devices that could operate for longer time, hence imposing design constraints. In this research, we investigate two design strategies that would allow us to efficiently process audio signals on embedded systems such as mobile phones and portable electronics. In the first strategy, we exploit properties of the human auditory system to process audio signals. We designed a sound enhancement algorithm to make piezoelectric loudspeakers sound ”richer" and "fuller." Piezoelectric speakers have a small form factor but exhibit poor response in the low-frequency region. In the algorithm, we combine psychoacoustic bass extension and dynamic range compression to improve the perceived bass coming out from the tiny speakers. We also developed an audio energy reduction algorithm for loudspeaker power management. The perceptually transparent algorithm extends the battery life of mobile devices and prevents thermal damage in speakers. This method is similar to audio compression algorithms, which encode audio signals in such a ways that the compression artifacts are not easily perceivable. Instead of reducing the storage space, however, we suppress the audio contents that are below the hearing threshold, therefore reducing the signal energy. In the second strategy, we use low-power analog circuits to process the signal before digitizing it. We designed an analog front-end for sound detection and implemented it on a field programmable analog array (FPAA). The system is an example of an analog-to-information converter. The sound classifier front-end can be used in a wide range of applications because programmable floating-gate transistors are employed to store classifier weights. Moreover, we incorporated a feature selection algorithm to simplify the analog front-end. A machine

  12. FREQUENCY ESTIMATION OF DISTORTED POWER SYSTEM SIGNALS USING MULTIPLE SIGNAL CLASSIFICATION ALGORITHM

    OpenAIRE

    UZUNOĞLU, Cengiz Polat

    2013-01-01

    In this paper a sub-space based fundamental frequency estimator of multiple signal classification (MUSIC) algorithm for distorted power system signals is proposed. Noise and signal sub-spaces are obtained from eigenvalue decomposition and desired frequency is estimated. Distortion level of the power system signals which have been observed from measurements may affect the accuracy of frequency measurement in a power system. Thus, the proposed method is employed to decompose noise sub-space for...

  13. Decision-aided maximum likelihood phase estimation with optimum block length in hybrid QPSK/16QAM coherent optical WDM systems

    Science.gov (United States)

    Zhang, Yong; Wang, Yulong

    2016-01-01

    We propose a general model to entirely describe XPM effects induced by 16QAM channels in hybrid QPSK/16QAM wavelength division multiplexed (WDM) systems. A power spectral density (PSD) formula is presented to predict the statistical properties of XPM effects at the end of dispersion management (DM) fiber links. We derive the analytical expression of phase error variance for optimizing block length of QPSK channel coherent receiver with decision-aided (DA) maximum-likelihood (ML) phase estimation (PE). With our theoretical analysis, the optimum block length can be employed to improve the performance of coherent receiver. Bit error rate (BER) performance in QPSK channel is evaluated and compared through both theoretical derivation and Monte Carlo simulation. The results show that by using the DA-ML with optimum block length, bit signal-to-noise ratio (SNR) improvement over DA-ML with fixed block length of 10, 20 and 40 at BER of 10-3 is 0.18 dB, 0.46 dB and 0.65 dB, respectively, when in-line residual dispersion is 0 ps/nm.

  14. Millimeter-wave circuits and pulse compression radar baseband/analog signal processing blocks in silicon processes

    OpenAIRE

    Parlak, Mehmet

    2012-01-01

    The power dissipation and cost of the next generation pulse radar beamforming systems needs to be reduced for the imaging and surveillance sensors. This research work aims at developing and innovating the next generation, mobile hand-held, high performance radar systems for outdoor surveillance applications, i.e. pedestrian detection sensor. Integrating the low cost millimeter-wave (mm-wave) imaging array platforms with advanced analog/ baseband signal processing on silicon is proposed for re...

  15. On parallel multisplitting block iterative methods for linear systems arising in the numerical solution of Euler equations

    OpenAIRE

    Zhang, Cheng-Yi; Luo, Shuanghua; Xu, Zongben

    2014-01-01

    The paper studies the convergence of some parallel multisplitting block iterative methods for the solution of linear systems arising in the numerical solution of Euler equations. Some sufficient conditions for convergence are proposed. As special cases the convergence of the parallel block generalized AOR (BGAOR), the parallel block AOR (BAOR), the parallel block generalized SOR (BGSOR), the parallel block SOR (BSOR), the extrapolated parallel BAOR and the extrapolated parallel BSOR methods a...

  16. Revitalisation of the control system of Shoshtanj TPP - Block 3 and TP 1 (Croatia)

    International Nuclear Information System (INIS)

    Block 3 of the Shoshtanj Thermal Power Plant was put into operation in 1960. With its 75 MW rated output on the Oerlikon turbine and the generation of 150 t/h of steam per each of the two Sulzer boilers fired by coal from the nearby Velenje mines, with Blocks I and 2, it was one of the biggest thermal power plants in Slovenia and in the former Yugoslavia. Although today, after the construction of much bigger Blocks 4 and 5, its share in the generation of electric and heating energy in the Republic of Slovenia is not so big, owing to its flexibility and reliability in operation, it is still a very important thermal power plant. Its importance conditioned numerous reconstructions with a view to increasing the efficiency of the block, extending its service life and increasing its ecological acceptability. A number of changes and upgradings were done, and ATM, Zagreb, today SIEMENS d.d. had an important share therein. This article deals with the revitalization of the control and monitoring system of Block 3 and Heating Station I of the Shoshtanj Thermal Power Plant. An emphasis is put on the installation of modern TELEPERM ME - AS220 EAI automation system and OS 525 operation and monitoring system. With the installation of the new automatic control system for Block 3 and TP I the main purpose of the reconstruction was achieved - the extension of the service life of the plant with an increased efficiency of its control. With the installation of the modem microprocessor automatic control system and the operation and monitoring system, a solid basis was ensured also for further upgrading and additions at later stages of reconstruction of Block 3, which would be finished by the complete replacement of the hydraulic oil control system and the relocation of the control of Block 3 and TP I in the new joint control room for Blocks 1, 2 and 3. The first stage of these extensive works starts with the reconstruction of the automatic control system of Blocks I and 2 which will be

  17. Synchronization of noisy systems by stochastic signals

    International Nuclear Information System (INIS)

    We study, in terms of synchronization, the nonlinear response of noisy bistable systems to a stochastic external signal, represented by Markovian dichotomic noise. We propose a general kinetic model which allows us to conduct a full analytical study of the nonlinear response, including the calculation of cross-correlation measures, the mean switching frequency, and synchronization regions. Theoretical results are compared with numerical simulations of a noisy overdamped bistable oscillator. We show that dichotomic noise can instantaneously synchronize the switching process of the system. We also show that synchronization is most pronounced at an optimal noise level emdash this effect connects this phenomenon with aperiodic stochastic resonance. Similar synchronization effects are observed for a stochastic neuron model stimulated by a stochastic spike train. copyright 1999 The American Physical Society

  18. Ritonavir blocks AKT signaling, activates apoptosis and inhibits migration and invasion in ovarian cancer cells

    Directory of Open Access Journals (Sweden)

    Weaver Donald W

    2009-04-01

    Full Text Available Abstract Background Ovarian cancer is the leading cause of mortality from gynecological malignancies, often undetectable in early stages. The difficulty of detecting the disease in its early stages and the propensity of ovarian cancer cells to develop resistance to known chemotherapeutic treatments dramatically decreases the 5-year survival rate. Chemotherapy with paclitaxel after surgery increases median survival only by 2 to 3 years in stage IV disease highlights the need for more effective drugs. The human immunodeficiency virus (HIV infection is characterized by increased risk of several solid tumors due to its inherent nature of weakening of immune system. Recent observations point to a lower incidence of some cancers in patients treated with protease inhibitor (PI cocktail treatment known as HAART (Highly Active Anti-Retroviral Therapy. Results Here we show that ritonavir, a HIV protease inhibitor effectively induced cell cycle arrest and apoptosis in ovarian cell lines MDH-2774 and SKOV-3 in a dose dependent manner. Over a 3 day period with 20 μM ritonavir resulted in the cell death of over 60% for MDAH-2774 compared with 55% in case of SKOV-3 cell line. Ritonavir caused G1 cell cycle arrest of the ovarian cancer cells, mediated by down modulating levels of RB phosphorylation and depleting the G1 cyclins, cyclin-dependent kinase and increasing their inhibitors as determined by gene profile analysis. Interestingly, the treatment of ritonavir decreased the amount of phosphorylated AKT in a dose-dependent manner. Furthermore, inhibition of AKT by specific siRNA synergistically increased the efficacy of the ritonavir-induced apoptosis. These results indicate that the addition of the AKT inhibitor may increase the therapeutic efficacy of ritonavir. Conclusion Our results demonstrate a potential use of ritonavir for ovarian cancer with additive effects in conjunction with conventional chemotherapeutic regimens. Since ritonavir is clinically

  19. RESEARCH OF WAVELET TRANSFORM INSTRUMENT SYSTEM FOR SIGNAL ANALYSIS

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    After brief describing the principle of wavelet transform (WT) of signals, a new signals analysis system based on wavelet transform is introduced. The design and development of the instrument of wavelet transform are described. A number of practical uses of this system demonstrate that wavelet transform system is specially functional in identifying and processing impulse, singular and nonsmooth signals,so that it should be evaluated the most advanced signal analyzing system.

  20. Second International Conference on Communications, Signal Processing, and Systems

    CERN Document Server

    Mu, Jiasong; Wang, Wei; Liang, Qilian; Pi, Yiming

    2014-01-01

    The Proceedings of The Second International Conference on Communications, Signal Processing, and Systems provides the state-of-art developments of Communications, Signal Processing, and Systems. The conference covered such topics as wireless communications, networks, systems, signal processing for communications. This book is a collection of contributions coming out of The Second International Conference on Communications, Signal Processing, and Systems (CSPS) held September 2013 in Tianjin, China.

  1. System and method for traffic signal timing estimation

    KAUST Repository

    Dumazert, Julien

    2015-12-30

    A method and system for estimating traffic signals. The method and system can include constructing trajectories of probe vehicles from GPS data emitted by the probe vehicles, estimating traffic signal cycles, combining the estimates, and computing the traffic signal timing by maximizing a scoring function based on the estimates. Estimating traffic signal cycles can be based on transition times of the probe vehicles starting after a traffic signal turns green.

  2. 3rd International Conference on Communications, Signal Processing, and Systems

    CERN Document Server

    Liang, Qilian; Wang, Wei; Zhang, Baoju; Pi, Yiming

    2015-01-01

    The Proceedings of The Third International Conference on Communications, Signal Processing, and Systems provides the state-of-art developments of communications, signal processing, and systems. This book is a collection of contributions from the conference and covers such topics as wireless communications, networks, systems, and signal processing for communications. The conference was held July 2014 in Hohhot, Inner Mongolia, China.

  3. Modeling of HDD Head Positioning Systems Regarded as Robot Manipulators Using Block Matrices

    OpenAIRE

    Trawinski, Tomasz; Witula, Roman

    2010-01-01

    The formulated dynamics block matrix of multilayer head positioning system consist of submatrixes which are related directly with structure of his kinematic chain. The dynamic block matrix consists of: bough self inertial matrix, self inertial matrix of branches, branch-bough inertial coupling matrix. The bough self inertial matrix is always one by one dimensional. But this matrix is very sensitive for increase of numbers of branches, adding one new branch into kinematic chains it result in t...

  4. Modular Analysis of Sequential Solution Methods for Almost Block Diagonal Systems of Equations

    OpenAIRE

    El-Mistikawy, Tarek M. A.

    2013-01-01

    Almost block diagonal linear systems of equations can be exemplified by two modules. This makes it possible to construct all sequential forms of band and/or block elimination methods. It also allows easy assessment of the methods on the basis of their operation counts, storage needs, and admissibility of partial pivoting. The outcome of the analysis and implementation is to discover new methods that outperform a well-known method, a modification of which is, therefore, advocated.

  5. A completely transparent, adhesively bonded soda-lime glass block masonry system

    OpenAIRE

    Faidra Oikonomopoulou; Fred Veer; Rob Nijsse; K. Baardolf

    2015-01-01

    A pioneering, all transparent, self-supporting glass block facade is presented in this paper. Previously realized examples utilize embedded metal components in order to obtain the desired structural performance despite the fact that these elements greatly affect the facade’s overall transparency level. Undeniably, the oxymoron ‘transparency and strength’ remains the prime concern in such applications. In this paper, a new, innovative structural system for glass block facades is described, whi...

  6. AN OPTIMAL BLOCK PREVENTIVE MAINTENANCE POLICY FOR A MULTI-UNIT SYSTEM CONSIDERING IMPERFECT MAINTENANCE

    OpenAIRE

    Park, J. H.; Lee, S. C.; J. W. HONG; C. H. LIE

    2009-01-01

    A block preventive maintenance (PM) policy for a multi-unit system composed of identical units is investigated in this paper. The block PM model of this paper considers periodic inspection and periodic imperfect maintenance. The imperfect maintenance effects are formulated using improvement factor and age reduction model. We define variables of maintenance policy as the inspection period and the PM period and obtain an optimal maintenance policy which minimizes the average total cost. A numer...

  7. Motor activity of stomach and duodenum while blocking NO-ergic system

    OpenAIRE

    O. O. Galyns’ky; A. S. Trushenko; V. O. Galyns’ky; O. V. Severynovs’ka; A. I. Rudenko

    2010-01-01

    The features of ultradian rhythms of the stomach and duodenum of rats under different time spans of blocking NO-synthase and the associated disturbance of regulatory mechanisms have been investigated. The functional relationship between changes in the МEA of stomach and duodenum, as well as the morphological status of the mucous membrane under disturbance of the nitric monoxide synthesis have been established. Each time blocking NO-ergic system caused an increase in motor performance index of...

  8. ANALYSIS OF EXISTING AND PROSPECTIVE TECHNICAL CONTROL SYSTEMS OF NUMERIC CODES AUTOMATIC BLOCKING

    Directory of Open Access Journals (Sweden)

    A. M. Beznarytnyy

    2013-09-01

    Full Text Available Purpose. To identify the characteristic features of the engineering control measures system of automatic block of numeric code, identifying their advantages and disadvantages, to analyze the possibility of their use in the problems of diagnosing status of the devices automatic block and setting targets for the development of new diagnostic systems. Methodology. In order to achieve targets the objective theoretical and analytical method and the method of functional analysis have been used. Findings. The analysis of existing and future facilities of the remote control and diagnostics automatic block devices had shown that the existing systems of diagnosis were not sufficiently informative, designed primarily to control the discrete parameters, which in turn did not allow them to construct a decision support subsystem. In developing of new systems of technical diagnostics it was proposed to use the principle of centralized distributed processing of diagnostic data, to include a subsystem support decision-making in to the diagnostics system, it will reduce the amount of work to maintain the devices blocking and reduce recovery time after the occurrence injury. Originality. As a result, the currently existing engineering controls facilities of automatic block can not provide a full assessment of the state distillation alarms and locks. Criteria for the development of new systems of technical diagnostics with increasing amounts of diagnostic information and its automatic analysis were proposed. Practical value. These results of the analysis can be used in practice in order to select the technical control of automatic block devices, as well as the further development of diagnostic systems automatic block that allows for a gradual transition from a planned preventive maintenance service model to the actual state of the monitored devices.

  9. Sorafenib inhibits tumor growth and vascularization of rhabdomyosarcoma cells by blocking IGF-1R-mediated signaling

    Directory of Open Access Journals (Sweden)

    Wessen Maruwge

    2008-11-01

    Full Text Available Wessen Maruwge1, Pádraig D’Arcy1, Annika Folin1,2, Slavica Brnjic1, Johan Wejde1, Anthony Davis1, Fredrik Erlandsson3, Jonas Bergh1,2, Bertha Brodin11Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden; 2Radiumhemmet, Karolinska University Hospital, Stockholm, Sweden; 3Bayer Pharmaceutical Corporation, SwedenAbstract: The growth of many soft tissue sarcomas is dependent on aberrant growth factor signaling, which promotes their proliferation and motility. With this in mind, we evaluated the effect of sorafenib, a receptor tyrosine kinase inhibitor, on cell growth and apoptosis in sarcoma cell lines of various histological subtypes. We found that sorafenib effectively inhibited cell proliferation in rhabdomyosarcoma, synovial sarcoma and Ewing’s sarcoma with IC50 values <5 µM. Sorafenib effectively induced growth arrest in rhabdomyosarcoma cells, which was concurrent with inhibition of Akt and Erk signaling. Studies of ligand-induced phosphorylation of Erk and Akt in rhabdomyosarcoma cells showed that insulin-like growth factor-1 is a potent activator, which can be blocked by treatment with sorafenib. In vivo sorafenib treatment of rhabdomyosarcoma xenografts had a significant inhibitory effect on tumor growth, which was associated with inhibited vascularization and enhanced necrosis in the adjacent tumor stroma. Our results demonstrate that in vitro and in vivo growth of rhabdomyosarcoma can be suppressed by treatment with sorafenib, and suggests the possibilities of using sorafenib as a potential adjuvant therapy for the treatment of rhabdomyosarcoma.Keywords: soft tissue sarcoma, kinase inhibitors, targeted therapy, vascularization

  10. Automated Pulmonary Nodule Detection System in Computed Tomography Images: A Hierarchical Block Classification Approach

    Directory of Open Access Journals (Sweden)

    Wook-Jin Choi

    2013-01-01

    Full Text Available A computer-aided detection (CAD system is helpful for radiologists to detect pulmonary nodules at an early stage. In this paper, we propose a novel pulmonary nodule detection method based on hierarchical block classification. The proposed CAD system consists of three steps. In the first step, input computed tomography images are split into three-dimensional block images, and we apply entropy analysis on the block images to select informative blocks. In the second step, the selected block images are segmented and adjusted for detecting nodule candidates. In the last step, we classify the nodule candidate images into nodules and non-nodules. We extract feature vectors of the objects in the selected blocks. Lastly, the support vector machine is applied to classify the extracted feature vectors. Performance of the proposed system is evaluated on the Lung Image Database Consortium database. The proposed method has reduced the false positives in the nodule candidates significantly. It achieved 95.28% sensitivity with only 2.27 false positives per scan.

  11. A completely transparent, adhesively bonded soda-lime glass block masonry system

    Directory of Open Access Journals (Sweden)

    F. Oikonomopoulou

    2015-01-01

    Full Text Available A pioneering, all transparent, self-supporting glass block facade is presented in this paper. Previously realized examples utilize embedded metal components in order to obtain the desired structural performance despite the fact that these elements greatly affect the facade’s overall transparency level. Undeniably, the oxymoron ‘transparency and strength’ remains the prime concern in such applications. In this paper, a new, innovative structural system for glass block facades is described, which demonstrably meets both criteria. The structure is exclusively constructed by monolithic glass blocks, bonded with a colourless, UV-curing adhesive, obtaining thus a maximum transparency. In addition, the desired structural performance is achieved solely through the masonry system, without any opaque substructure. Differing from previous realized projects, solid soda-lime glass blocks are used rather than borosilicate ones. This article provides an overview of the integrated architectural and structural design and discusses the choice of materials. The structural verification of the system is demonstrated. The results show that the adhesively bonded glass block structure has the required self-structural behaviour, but only if strict tolerances are met in the geometry of the glass blocks.

  12. A completely transparent, adhesively bonded soda-lime glass block masonry system

    Directory of Open Access Journals (Sweden)

    Faidra Oikonomopoulou

    2015-06-01

    Full Text Available A pioneering, all transparent, self-supporting glass block facade is presented in this paper. Previously realized examples utilize embedded metal components in order to obtain the desired structural performance despite the fact that these elements greatly affect the facade’s overall transparency level. Undeniably, the oxymoron ‘transparency and strength’ remains the prime concern in such applications. In this paper, a new, innovative structural system for glass block facades is described, which demonstrably meets both criteria. The structure is exclusively constructed by monolithic glass blocks, bonded with a colourless, UV-curing adhesive, obtaining thus a maximum transparency. In addition, the desired structural performance is achieved solely through the masonry system, without any opaque substructure. Differing from previous realized projects, solid soda-lime glass blocks are used rather than borosilicate ones. This article provides an overview of the integrated architectural and structural design and discusses the choice of materials. The structural verification of the system is demonstrated. The results show that the adhesively bonded glass block structure has the required self-structural behaviour, but only if strict tolerances are met in the geometry of the glass blocks.  

  13. Pentamidine blocks the interaction between mutant S100A5 and RAGE V domain and inhibits the RAGE signaling pathway.

    Science.gov (United States)

    Cho, Ching Chang; Chou, Ruey Hwang; Yu, Chin

    2016-08-19

    The human S100 protein family contains small, dimeric and acidic proteins that contain two EF-hand motifs and bind calcium. When S100A5 binds calcium, its conformation changes and promotes interaction with the target protein. The extracellular domain of RAGE (Receptor of Advanced Glycation End products) contain three domains: C1, C2 and V. The RAGE V domain is the target protein of S100A5 that promotes cell survival, growth and differentiation by activating several signaling pathways. Pentamidine is an apoptotic and antiparasitic drug that is used to treat or prevent pneumonia. Here, we found that pentamidine interacts with S100A5 using HSQC titration. We elucidated the interactions of S100A5 with RAGE V domain and pentamidine using fluorescence and NMR spectroscopy. We generated two binary models-the S100A5-RAGE V domain and S100A5-Pentamidine complex-and then observed that the pentamidine and RAGE V domain share a similar binding region in mS100A5. We also used the WST-1 assay to investigate the bioactivity of S100A5, RAGE V domain and pentamidine. These results indicated that pentamidine blocks the binding between S100A5 and RAGE V domain. This finding is useful for the development of new anti-proliferation drugs. PMID:27297108

  14. A fast direct method for block triangular Toeplitz-like with tri-diagonal block systems from time-fractional partial differential equations

    Science.gov (United States)

    Ke, Rihuan; Ng, Michael K.; Sun, Hai-Wei

    2015-12-01

    In this paper, we study the block lower triangular Toeplitz-like with tri-diagonal blocks system which arises from the time-fractional partial differential equation. Existing fast numerical solver (e.g., fast approximate inversion method) cannot handle such linear system as the main diagonal blocks are different. The main contribution of this paper is to propose a fast direct method for solving this linear system, and to illustrate that the proposed method is much faster than the classical block forward substitution method for solving this linear system. Our idea is based on the divide-and-conquer strategy and together with the fast Fourier transforms for calculating Toeplitz matrix-vector multiplication. The complexity needs O (MNlog2 ⁡ M) arithmetic operations, where M is the number of blocks (the number of time steps) in the system and N is the size (number of spatial grid points) of each block. Numerical examples from the finite difference discretization of time-fractional partial differential equations are also given to demonstrate the efficiency of the proposed method.

  15. Analysis of the seismic signals generated by controlled single-block rockfalls on soft clay shales sediments: the Rioux Bourdoux slope experiment (French Alps).

    Science.gov (United States)

    Hibert, Clément; Provost, Floriane; Malet, Jean-Philippe; Bourrier, Franck; Berger, Frédéric; Bornemann, Pierrick; Borgniet, Laurent; Tardif, Pascal; Mermin, Eric

    2016-04-01

    Understanding the dynamics of rockfalls is critical to mitigate the associated hazards but is made very difficult by the nature of these natural disasters that makes them hard to observe directly. Recent advances in seismology allow to determine the dynamics of the largest landslides on Earth from the very low-frequency seismic waves they generate. However, the vast majority of rockfalls that occur worldwide are too small to generate such low-frequency seismic waves and thus these methods cannot be used to reconstruct their dynamics. However, if seismic sensors are close enough, these events will generate high-frequency seismic signals. Unfortunately we cannot yet use these high-frequency seismic records to infer parameters synthetizing the rockfall dynamics as the source of these waves is not well understood. One of the first steps towards understanding the physical processes involved in the generation of high-frequency seismic waves by rockfalls is to study the link between the dynamics of a single block propagating along a well-known path and the features of the seismic signal generated. We conducted controlled releases of single blocks of limestones in a gully of clay-shales (e.g. black marls) in the Rioux Bourdoux torrent (French Alps). 28 blocks, with masses ranging from 76 kg to 472 kg, were released. A monitoring network combining high-velocity cameras, a broadband seismometer and an array of 4 high-frequency seismometers was deployed near the release area and along the travel path. The high-velocity cameras allow to reconstruct the 3D trajectories of the blocks, to estimate their velocities and the position of the different impacts with the slope surface. These data are compared to the seismic signals recorded. As the distance between the block and the seismic sensors at the time of each impact is known, we can determine the associated seismic signal amplitude corrected from propagation and attenuation effects. We can further compare the velocity, the

  16. From building blocks to the embedded condition monitoring system

    Czech Academy of Sciences Publication Activity Database

    Ettler, P.; Dedecius, Kamil; Pavelková, Lenka; Juričič, D.; Boškoski, P.; Steiner, I.

    Maribor: IFAC, 2015, s. 135-140. (IFAC-PapersOnline. Volume 48, Issue 10). ISSN 1474-6670. [2nd IFAC Conference on Embedded Systems, Computational Intelligence and Telematics in Control. Maribor (SI), 22.06.2015-24.06.2015] R&D Projects: GA MŠk 7D12004 Institutional support: RVO:67985556 Keywords : diagnostic programs * failure detection * probabilistic logic Subject RIV: JB - Sensors, Measurment, Regulation http://library.utia.cas.cz/separaty/2015/AS/dedecius-0445801.pdf

  17. 78 FR 47822 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System

    Science.gov (United States)

    2013-08-06

    ... discontinuance of the automatic block signal (ABS) system on Main Line 1 and 2, from Milepost (MP) 1.2 Bliss to... that the ABS system is no longer needed for freight switching operations. There are no through freight... published on April 11, 2000 (65 FR 19477). Robert C. Lauby, Deputy Associate Administrator for...

  18. Space Time Block Coded Multi-user CDMA Systems over Rayleigh Fading Channel

    OpenAIRE

    Mamun, M. Shahriar; Hussain, Jamil; Haque, Md. Hasibul; Shafik, Rishad Ahmed

    2008-01-01

    This paper investigates the performance and capacity of space time block coded (STBC) multi-user CDMA system over Rayleigh fading channel condition using multiple transmit antennas. Using simulation and analytical approach, we show that STBC CDMA system has increased performance in cellular networks. We also compare the performance of this system with the typical CDMA system and show that STBC and multiple transmit antennas for multi-user CDMA system provide performance gain without any need ...

  19. Traffic Modelling for Moving-Block Train Control System

    Institute of Scientific and Technical Information of China (English)

    TANG Tao; LI Ke-Ping

    2007-01-01

    This paper presents a new cellular automaton (CA) model for train control system simulation.In the proposed CA model,the driver reactions to train movements are captured by some updated rules.The space-time diagram of traffic flow and the trajectory of train movement is used to obtain insight into the characteristic behavior of railway traffic flow.A number of simulation results demonstrate that the proposed CA model can be successfully used for the simulations of railway traffic.Not only the characteristic behavior of railway traffic flow can be reproduced,but also the simulation values of the minimum time headway are close to the theoretical values.

  20. Traffic Modelling for Moving-Block Train Control System

    International Nuclear Information System (INIS)

    This paper presents a new cellular automaton (CA) model for train control system simulation. In the proposed CA model, the driver reactions to train movements are captured by some updated rules. The space-time diagram of traffic flow and the trajectory of train movement is used to obtain insight into the characteristic behavior of railway traffic flow. A number of simulation results demonstrate that the proposed CA model can be successfully used for the simulations of railway traffic. Not only the characteristic behavior of railway traffic flow can be reproduced, but also the simulation values of the minimum time headway are close to the theoretical values.

  1. Rapamycin targeting mTOR and hedgehog signaling pathways blocks human rhabdomyosarcoma growth in xenograft murine model

    Energy Technology Data Exchange (ETDEWEB)

    Kaylani, Samer Z. [Division of Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, 1600 7th Avenue South, ACC 414, Birmingham, AL 35233 (United States); Xu, Jianmin; Srivastava, Ritesh K. [Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, 1530 3rd Avenue South, VH 509, Birmingham, AL 35294-0019 (United States); Kopelovich, Levy [Division of Cancer Prevention, National Cancer Institute, Bethesda (United States); Pressey, Joseph G. [Division of Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, 1600 7th Avenue South, ACC 414, Birmingham, AL 35233 (United States); Athar, Mohammad, E-mail: mathar@uab.edu [Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, 1530 3rd Avenue South, VH 509, Birmingham, AL 35294-0019 (United States)

    2013-06-14

    Graphical abstract: Intervention of poorly differentiated RMS by rapamycin: In poorly differentiated RMS, rapamycin blocks mTOR and Hh signaling pathways concomitantly. This leads to dampening in cell cycle regulation and induction of apoptosis. This study provides a rationale for the therapeutic intervention of poorly differentiated RMS by treating patients with rapamycin alone or in combination with other chemotherapeutic agents. -- Highlights: •Rapamycin abrogates RMS tumor growth by modulating proliferation and apoptosis. •Co-targeting mTOR/Hh pathways underlie the molecular basis of effectiveness. •Reduction in mTOR/Hh pathways diminish EMT leading to reduced invasiveness. -- Abstract: Rhabdomyosarcomas (RMS) represent the most common childhood soft-tissue sarcoma. Over the past few decades outcomes for low and intermediate risk RMS patients have slowly improved while patients with metastatic or relapsed RMS still face a grim prognosis. New chemotherapeutic agents or combinations of chemotherapies have largely failed to improve the outcome. Based on the identification of novel molecular targets, potential therapeutic approaches in RMS may offer a decreased reliance on conventional chemotherapy. Thus, identification of effective therapeutic agents that specifically target relevant pathways may be particularly beneficial for patients with metastatic and refractory RMS. The PI3K/AKT/mTOR pathway has been found to be a potentially attractive target in RMS therapy. In this study, we provide evidence that rapamycin (sirolimus) abrogates growth of RMS development in a RMS xenograft mouse model. As compared to a vehicle-treated control group, more than 95% inhibition in tumor growth was observed in mice receiving parenteral administration of rapamycin. The residual tumors in rapamycin-treated group showed significant reduction in the expression of biomarkers indicative of proliferation and tumor invasiveness. These tumors also showed enhanced apoptosis

  2. Increased Percentage of Passing Grades on the Massachusetts Comprehensive Assessment System after Implementation of Block Scheduling

    Science.gov (United States)

    Forman, Eric D.

    2009-01-01

    This study examined one public school system's change in its bell scheduling format from a seven period day to block scheduling. The data collected was from a three year period of the grade 10 students passing the Massachusetts Comprehensive Assessment System exam. Students in Massachusetts must pass the mathematics and English/language arts…

  3. Reconciling Compressive Sampling Systems for Spectrally-sparse Continuous-time Signals

    CERN Document Server

    Lexa, Michael A; Thompson, John S

    2011-01-01

    The Random Demodulator (RD) and the Modulated Wideband Converter (MWC) are two recently proposed compressed sensing (CS) techniques for the acquisition of continuous-time spectrally-sparse signals. They extend the standard CS paradigm from sampling discrete, finite dimensional signals to sampling continuous and possibly infinite dimensional ones, and thus establish the ability to capture these signals at sub-Nyquist sampling rates. The RD and the MWC have remarkably similar structures (similar block diagrams), but their reconstruction algorithms and signal models strongly differ. To date, few results exist that compare these systems, and owing to the potential impacts they could have on spectral estimation in applications like electromagnetic scanning and cognitive radio, we more fully investigate their relationship in this paper. Specifically, we show that the RD and the MWC are both based on the general concept of random filtering, but that the sampling functions characterising the systems differ significan...

  4. Differential Space-Time Block Code Modulation for DS-CDMA Systems

    Directory of Open Access Journals (Sweden)

    Liu Jianhua

    2002-01-01

    Full Text Available A differential space-time block code (DSTBC modulation scheme is used to improve the performance of DS-CDMA systems in fast time-dispersive fading channels. The resulting scheme is referred to as the differential space-time block code modulation for DS-CDMA (DSTBC-CDMA systems. The new modulation and demodulation schemes are especially studied for the down-link transmission of DS-CDMA systems. We present three demodulation schemes, referred to as the differential space-time block code Rake (D-Rake receiver, differential space-time block code deterministic (D-Det receiver, and differential space-time block code deterministic de-prefix (D-Det-DP receiver, respectively. The D-Det receiver exploits the known information of the spreading sequences and their delayed paths deterministically besides the Rake type combination; consequently, it can outperform the D-Rake receiver, which employs the Rake type combination only. The D-Det-DP receiver avoids the effect of intersymbol interference and hence can offer better performance than the D-Det receiver.

  5. Xiaokeping mixture inhibits diabetic nephropathy in streptozotocin-induced rats through blocking TGF-β1/Smad7 signaling

    Directory of Open Access Journals (Sweden)

    Xin C

    2015-11-01

    Full Text Available Chuanwei Xin, Zhongni Xia, Cheng Jiang, Mengmeng Lin, Gonghua Li Department of Pharmacy, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, People’s Republic of China Background: Diabetic nephropathy (DN is a major cause of chronic kidney failure and characterized by excessive deposition of extracellular matrix. Evidence have shown that transforming growth factor-β1 (TGF-β1 is a key mediator in the development of DN. However, treatment of DN by blocking the TGF-β1/Smad7 pathway remains limited. Xiaokeping mixture (XKP, a traditional Chinese herbal compound, has been used for treatment in patients with DN for many years.Methods: In the present study, TGF-β1/Smad7 pathway analysis was used to evaluate the therapeutic effect of XKP on DN rats induced by streptozotocin and to address the underlying molecular mechanism. Male rats were divided into four groups: normal control, untreated control group (fed with high fat, irbesartan-treated DN, and XKP-treated DN, respectively. Levels of serum creatinine, blood urea nitrogen, urine protein of 24 hours, and triacylglycerol were detected. Pathological changes of renal tissues were observed by hematoxylin–eosin staining. Immunohistochemical and Western blot analysis were used to detect the expressions of TGF-β1 and Smad7.Results: The results demonstrated that XKP can effectively reduce the levels of glucose, serum creatinine, blood urea nitrogen, urine protein of 24 hours, and triacylglycerol. Further studies indicated that inhibition of DN in XKP-treated DN rats was associated with inhibition of TGF-β1/Smad7 signaling as demonstrated by downregulation of TGF-β1 but upregulation of Smad7.Conclusion: The data obtained from the present study indicate that XKP may be a therapeutic agent for DN. Keywords: Xiaokeping mixture, diabetic nephropathy, transforming growth factor-beta, Smad7

  6. System Performance of Concatenated STBC and Block Turbo Codes in Dispersive Fading Channels

    Directory of Open Access Journals (Sweden)

    Kam Tai Chan

    2005-05-01

    Full Text Available A new scheme of concatenating the block turbo code (BTC with the space-time block code (STBC for an OFDM system in dispersive fading channels is investigated in this paper. The good error correcting capability of BTC and the large diversity gain characteristics of STBC can be achieved simultaneously. The resulting receiver outperforms the iterative convolutional Turbo receiver with maximum- a-posteriori-probability expectation maximization (MAP-EM algorithm. Because of its ability to perform the encoding and decoding processes in parallel, the proposed system is easy to implement in real time.

  7. COMPUTER-BASED ECG SIGNAL ANALYSIS AND MONITORING SYSTEM

    OpenAIRE

    Nasser N. Khamiss Al-Ani; Hadeel Kassim Al-Jobouri

    2008-01-01

    This paper deals with the design and implementation of an ECG system. The proposed system gives a new concept of ECG signal manipulation, storing, and editing. It consists mainly of hardware circuits and the related software. The hardware includes the circuits of ECG signals capturing, and system interfaces. The software is written using Visual Basic languages, to perform the task of identification of the ECG signal. The main advantage of the system is to provide a reported ECG recording on a...

  8. An Assessment Methodology for Emergency Vehicle Traffic Signal Priority Systems

    OpenAIRE

    McHale, Gene Michael

    2002-01-01

    Emergency vehicle traffic signal priority systems allow emergency vehicles such as fire and emergency medical vehicles to request and receive a green traffic signal indication when approaching an intersection. Such systems have been around for a number of years, however, there is little understanding of the costs and benefits of such systems once they are deployed. This research develops an improved method to assess the travel time impacts of emergency vehicle traffic signal priority system...

  9. Structure-property relationships in multilayered polymeric system and olefinic block copolymers

    Science.gov (United States)

    Khariwala, Devang

    Chapter 1. The effect of tie-layer thickness on delamination behavior of polypropylene/tie-layer/Nylon-6 multilayers is examined in this study. Various maleated polypropylene resins were compared for their effectiveness as tie-layers. Delamination failure occurred cohesively in all the multilayer systems. Two adhesion regimes were defined based on the change in slope of the linear relationship between the delamination toughness and the tie-layer thickness. The measured delamination toughness of the various tie-layers was quantitatively correlated to the damage zone length formed at the crack tip. In addition, the effect of tie-layer thickness on the multilayer tensile properties was correlated with the delamination behavior. The fracture strain of the multilayers decreased with decreasing tie-layer thickness. Examination of the prefracture damage mechanism of stretched multilayers revealed good correlation with the delamination toughness of the tie-layers. In thick tie-layers (>2microm) the delamination toughness of the tie-layers was large enough to prevent delamination of multilayers when they were stretched. In the thin tie-layers (block copolymers with properties typical of thermoplastic elastomers. The block copolymers synthesized by chain shuttling technology consist of crystallizable ethylene-octene blocks with low comonomer content and high melting temperature (hard blocks), alternating with amorphous ethylene-octene blocks with high comonomer content and low glass transition temperature (soft blocks). This study describes the material science of these unique polymers as characterized by thermal analysis, X-ray diffraction, microscopy, and tensile deformation. The crystallizable blocks are long enough to form well-organized lamellar crystals with the orthorhombic unit cell and high melting temperature. The lamellae are organized into space-filling spherulites in all compositions even in copolymers with only 18 wt% hard block. The morphology is consistent

  10. [Dynamic Pulse Signal Processing and Analyzing in Mobile System].

    Science.gov (United States)

    Chou, Yongxin; Zhang, Aihua; Ou, Jiqing; Qi, Yusheng

    2015-09-01

    In order to derive dynamic pulse rate variability (DPRV) signal from dynamic pulse signal in real time, a method for extracting DPRV signal was proposed and a portable mobile monitoring system was designed. The system consists of a front end for collecting and wireless sending pulse signal and a mobile terminal. The proposed method is employed to extract DPRV from dynamic pulse signal in mobile terminal, and the DPRV signal is analyzed both in the time domain and the frequency domain and also with non-linear method in real time. The results show that the proposed method can accurately derive DPRV signal in real time, the system can be used for processing and analyzing DPRV signal in real time. PMID:26904868

  11. A hearing aid on-chip system based on accuracy optimized front- and back-end blocks

    International Nuclear Information System (INIS)

    A hearing aid on-chip system based on accuracy optimized front- and back-end blocks is presented for enhancing the signal processing accuracy of the hearing aid. Compared with the conventional system, the accuracy optimized system is characterized by the dual feedback network and the gain compensation technique used in the front- and back-end blocks, respectively, so as to alleviate the nonlinearity distortion caused by the output swing. By using the technique, the accuracy of the whole hearing aid system can be significantly improved. The prototype chip has been designed with a 0.13 μm standard CMOS process and tested with 1 V supply voltage. The measurement results show that, for driving a 16 Ω loudspeaker with a normalized output level of 300 mVp-p, the total harmonic distortion reached about −60 dB, achieving at least three times reduction compared to the previously reported works. In addition, the typical input referred noise is only about 5 μVrms. (semiconductor integrated circuits)

  12. Effective System for Automatic Bundle Block Adjustment and Ortho Image Generation from Multi Sensor Satellite Imagery

    Science.gov (United States)

    Akilan, A.; Nagasubramanian, V.; Chaudhry, A.; Reddy, D. Rajesh; Sudheer Reddy, D.; Usha Devi, R.; Tirupati, T.; Radhadevi, P. V.; Varadan, G.

    2014-11-01

    Block Adjustment is a technique for large area mapping for images obtained from different remote sensingsatellites.The challenge in this process is to handle huge number of satellite imageries from different sources with different resolution and accuracies at the system level. This paper explains a system with various tools and techniques to effectively handle the end-to-end chain in large area mapping and production with good level of automation and the provisions for intuitive analysis of final results in 3D and 2D environment. In addition, the interface for using open source ortho and DEM references viz., ETM, SRTM etc. and displaying ESRI shapes for the image foot-prints are explained. Rigorous theory, mathematical modelling, workflow automation and sophisticated software engineering tools are included to ensure high photogrammetric accuracy and productivity. Major building blocks like Georeferencing, Geo-capturing and Geo-Modelling tools included in the block adjustment solution are explained in this paper. To provide optimal bundle block adjustment solution with high precision results, the system has been optimized in many stages to exploit the full utilization of hardware resources. The robustness of the system is ensured by handling failure in automatic procedure and saving the process state in every stage for subsequent restoration from the point of interruption. The results obtained from various stages of the system are presented in the paper.

  13. A Parallel Algorithm for Solving Block-diagonal Structured Large Linear System

    Institute of Scientific and Technical Information of China (English)

    SHEN Jie; ZHANG Zhong-lin; CHENG Ji-lin

    2001-01-01

    A parallel algorithm for solving block-diagonal structured large linear system is presented.This algorithm is based on the "gradient-simplex" method. It partitions a large linear system into several small linear subsystems so that they can be solved in parallel. The algorithm has the merit of high speed and is suitable for the large linear systems with less coupling constrains. The efficiency and applicability of the method is also analyzed.

  14. Genetic polymorphism of immunogenic signaling system

    Directory of Open Access Journals (Sweden)

    V. N. Tzygan

    2014-09-01

    Full Text Available The functional studies underline the importance of maintaining structural integrity of the innate immune components of intracellular signaling. The molecular structures for a number of proteins and protein domains in immune signaling have been determined. These structures have assisted us in understanding innate immunity at the molecular level. A polymorphisms modulating innate immunity signal transduction has recently been shown to influence human susceptibility to many different infections, providing one more indication of the potential of host genetics to reveal physiological pathways and mechanisms that influence resistance to infectious diseases. This lection describes recently determined structures involved in TLR signaling.

  15. Digital signal processing in communication systems

    CERN Document Server

    Frerking, Marvin E

    1994-01-01

    An engineer's introduction to concepts, algorithms, and advancements in Digital Signal Processing. This lucidly written resource makes extensive use of real-world examples as it covers all the important design and engineering references.

  16. Information content in reflected global navigation satellite system signals

    DEFF Research Database (Denmark)

    Høeg, Per; Carlstrom, Anders

    2011-01-01

    The direct signals from satellites in global satellite navigation satellites systems (GNSS) as, GPS, GLONASS and GALILEO, constitute the primary source for positioning, navigation and timing from space. But also the reflected GNSS signals contain an important information content of signal travel...

  17. Low-Complexity Decoding of Block Turbo-Coded System with Antenna Diversity

    Directory of Open Access Journals (Sweden)

    Yanni Chen

    2003-12-01

    Full Text Available The goal of this paper is to reduce the decoding complexity of space-time block turbo-coded system with low performance degradation. Two block turbo-coded systems with antenna diversity are considered. These include the simple serial concatenation of error control code with space-time block code, and the recently proposed transmit antenna diversity scheme using forward error correction techniques. It is shown that the former performs better when compared to the latter in terms of bit error rate (BER under the same spectral efficiency (up to 7 dB at the BER of 10−5 for quasistatic channel with two transmit and two receive antennas. For the former system, a computationally efficient decoding approach is proposed for the soft decoding of space-time block code. Compared to its original maximum likelihood decoding algorithm, it can reduce the computation by up to 70% without any performance degradation. Additionally, for the considered outer code block turbo code, through reduction of test patterns scanned in the Chase algorithm and the alternative computation of its extrinsic information during iterative decoding, extra 0.3 dB to 0.4 dB coding gain is obtained if compared with previous approaches with negligible hardware overhead. The overall decoding complexity is approximately ten times less than that of the near-optimum block turbo decoder with coding gain loss of 0.5 dB at the BER of 10−5 over AWGN channel.

  18. Normal mode analysis of macromolecular systems with the mobile block Hessian method

    International Nuclear Information System (INIS)

    Until recently, normal mode analysis (NMA) was limited to small proteins, not only because the required energy minimization is a computationally exhausting task, but also because NMA requires the expensive diagonalization of a 3Na×3Na matrix with Na the number of atoms. A series of simplified models has been proposed, in particular the Rotation-Translation Blocks (RTB) method by Tama et al. for the simulation of proteins. It makes use of the concept that a peptide chain or protein can be seen as a subsequent set of rigid components, i.e. the peptide units. A peptide chain is thus divided into rigid blocks with six degrees of freedom each. Recently we developed the Mobile Block Hessian (MBH) method, which in a sense has similar features as the RTB method. The main difference is that MBH was developed to deal with partially optimized systems. The position/orientation of each block is optimized while the internal geometry is kept fixed at a plausible - but not necessarily optimized - geometry. This reduces the computational cost of the energy minimization. Applying the standard NMA on a partially optimized structure however results in spurious imaginary frequencies and unwanted coordinate dependence. The MBH avoids these unphysical effects by taking into account energy gradient corrections. Moreover the number of variables is reduced, which facilitates the diagonalization of the Hessian. In the original implementation of MBH, atoms could only be part of one rigid block. The MBH is now extended to the case where atoms can be part of two or more blocks. Two basic linkages can be realized: (1) blocks connected by one link atom, or (2) by two link atoms, where the latter is referred to as the hinge type connection. In this work we present the MBH concept and illustrate its performance with the crambin protein as an example

  19. Performance of multi-service system with retrials due to blocking and called-party-busy

    DEFF Research Database (Denmark)

    Stepanov, S.N.; Kokina, O.A.; Iversen, Villy Bæk

    In this paper we construct a model of a multi-service system with an arbitrary number of bandwidth flow demands, taking into account retrials due to both blocking along the route and to called-party-busy. An approximate algorithm for estimation of key performance measures is proposed, and the...

  20. BLOCK OF FUZZY MODELS FOR CALCULATION OF THE ECONOMIC PARAMETERS IN A TECHNOLOGICALLY INTEGRATED PRODUCTION SYSTEM

    Directory of Open Access Journals (Sweden)

    Baranovskaya T. P.

    2014-06-01

    Full Text Available The article describes the fuzzy-multiple approach and the block of fuzzy (interval mathematical models developed by the authors for calculating the amounts of material and financial flows, prices for bread and economic efficiency in a technologically integrated bread production system

  1. Extended block diagram method for a multi-state system reliability assessment

    International Nuclear Information System (INIS)

    The presented method extends the classical reliability block diagram method to a repairable multi-state system. It is very suitable for engineering applications since the procedure is well formalized and based on the natural decomposition of the entire multi-state system (the system is represented as a collection of its elements). Until now, the classical block diagram method did not provide the reliability assessment for the repairable multi-state system. The straightforward stochastic process methods are very difficult for engineering application in such cases due to the 'dimension damnation'-huge number of system states. The suggested method is based on the combined random processes and the universal generating function technique and drastically reduces the number of states in the multi-state model

  2. A convergence analysis for a sweeping preconditioner for block tridiagonal systems of linear equations

    KAUST Repository

    Bagci, Hakan

    2014-11-11

    We study sweeping preconditioners for symmetric and positive definite block tridiagonal systems of linear equations. The algorithm provides an approximate inverse that can be used directly or in a preconditioned iterative scheme. These algorithms are based on replacing the Schur complements appearing in a block Gaussian elimination direct solve by hierarchical matrix approximations with reduced off-diagonal ranks. This involves developing low rank hierarchical approximations to inverses. We first provide a convergence analysis for the algorithm for reduced rank hierarchical inverse approximation. These results are then used to prove convergence and preconditioning estimates for the resulting sweeping preconditioner.

  3. Intelligent Signal Processing for Detection System Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Fu, C Y; Petrich, L I; Daley, P F; Burnham, A K

    2004-06-18

    A wavelet-neural network signal processing method has demonstrated approximately tenfold improvement in the detection limit of various nitrogen and phosphorus compounds over traditional signal-processing methods in analyzing the output of a thermionic detector attached to the output of a gas chromatograph. A blind test was conducted to validate the lower detection limit. All fourteen of the compound spikes were detected when above the estimated threshold, including all three within a factor of two above. In addition, two of six were detected at levels 1/2 the concentration of the nominal threshold. We would have had another two correct hits if we had allowed human intervention to examine the processed data. One apparent false positive in five nulls was traced to a solvent impurity, whose presence was identified by running a solvent aliquot evaporated to 1% residual volume, while the other four nulls were properly classified. We view this signal processing method as broadly applicable in analytical chemistry, and we advocate that advanced signal processing methods be applied as directly as possible to the raw detector output so that less discriminating preprocessing and post-processing does not throw away valuable signal.

  4. Intelligent Signal Processing for Detection System Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Fu, C Y; Petrich, L I; Daley, P F; Burnham, A K

    2004-12-05

    A wavelet-neural network signal processing method has demonstrated approximately tenfold improvement over traditional signal-processing methods for the detection limit of various nitrogen and phosphorus compounds from the output of a thermionic detector attached to a gas chromatograph. A blind test was conducted to validate the lower detection limit. All fourteen of the compound spikes were detected when above the estimated threshold, including all three within a factor of two above the threshold. In addition, two of six spikes were detected at levels of 1/2 the concentration of the nominal threshold. Another two of the six would have been detected correctly if we had allowed human intervention to examine the processed data. One apparent false positive in five nulls was traced to a solvent impurity, whose presence was subsequently identified by analyzing a solvent aliquot evaporated to 1% residual volume, while the other four nulls were properly classified. We view this signal processing method as broadly applicable in analytical chemistry, and we advocate that advanced signal processing methods should be applied as directly as possible to the raw detector output so that less discriminating preprocessing and post-processing does not throw away valuable signal.

  5. Cartesian formulation of the mobile block Hessian approach to vibrational analysis in partially optimized systems

    Science.gov (United States)

    Ghysels, A.; Van Neck, D.; Waroquier, M.

    2007-10-01

    Partial optimization is a useful technique to reduce the computational load in simulations of extended systems. In such nonequilibrium structures, the accurate calculation of localized vibrational modes can be troublesome, since the standard normal mode analysis becomes inappropriate. In a previous paper [A. Ghysels et al., J. Chem. Phys. 126, 224102 (2007)], the mobile block Hessian (MBH) approach was presented to deal with the vibrational analysis in partially optimized systems. In the MBH model, the nonoptimized regions of the system are represented by one or several blocks, which can move as rigid bodies with respect to the atoms of the optimized region. In this way unphysical imaginary frequencies are avoided and the translational/rotational invariance of the potential energy surface is fully respected. In this paper we focus on issues concerning the practical numerical implementation of the MBH model. The MBH normal mode equations are worked out for several coordinate choices. The introduction of a consistent group-theoretical notation facilitates the treatment of both the case of a single block and the case of multiple blocks. Special attention is paid to the formulation in terms of Cartesian variables, in order to provide a link with the standard output of common molecular modeling programs.

  6. FunBlocks. A Modular Framework for AmI System Development

    Directory of Open Access Journals (Sweden)

    Alfredo Piero Mateos Papis

    2012-07-01

    Full Text Available The last decade has seen explosive growth in the technologies required to implement Ambient Intelligence (AmI systems. Technologies such as facial and speech recognition, home networks, household cleaning robots, to name a few, have become commonplace. However, due to the multidisciplinary nature of AmI systems and the distinct requirements of different user groups, integrating these developments into full-scale systems is not an easy task. In this paper we propose FunBlocks, a minimalist modular framework for the development of AmI systems based on the function module abstraction used in the IEC 61499 standard for distributed control systems. FunBlocks provides a framework for the development of AmI systems through the integration of modules loosely joined by means of an event-driven middleware and a module and sensor/actuator catalog. The modular design of the FunBlocks framework allows the development of AmI systems which can be customized to a wide variety of usage scenarios.

  7. PAPR reduction in optical OFDM systems using asymmetrically clipping and signal scrambling technique

    Science.gov (United States)

    Chen, Lin; Fang, Yong; Huang, Qinghua; Sun, Yanzan

    2015-08-01

    Optical orthogonal frequency division multiplexing (OOFDM) is a promising technology in the next generation of high-speed and long-haul optical transmission, due to its high spectral efficiency, high speed of data transmission and strong ability of anti-dispersion. But optical OFDM system has a very high peak-to-average power ratio (PAPR). High PAPR will bring instantaneous high optical power to the optical OFDM system. Asymmetrically clipping and signal scrambling based on fast Hartley transform for PAPR reduction is proposed in optical OFDM system. Firstly, IFFT/FFT module in each sub-block of traditional signal scrambling technique is replaced with inverse fast Hartley transform (IFHT) and fast Hartley transform (FHT) module, which yield to the real signal in OOFDM system. Then, asymmetrically clipping technique is applied to turn it into a positive and real signal. Finally, the signal with the minimum PAPR is selected for transmission in the fiber channel. The PAPR of the optical OFDM signal can be reduced effectively. And without the Hermitian symmetry, the space and computational complexity are reduced accordingly.

  8. Block Structured Adaptive Mesh and Time Refinement for Hybrid, Hyperbolic + N-body Systems

    OpenAIRE

    Miniati, Francesco; Colella, Phillip

    2006-01-01

    We present a new numerical algorithm for the solution of coupled collisional and collisionless systems, based on the block structured adaptive mesh and time refinement strategy (AMR). We describe the issues associated with the discretization of the system equations and the synchronization of the numerical solution on the hierarchy of grid levels. We implement a code based on a higher order, conservative and directionally unsplit Godunov's method for hydrodynamics; a symmetric, time centered m...

  9. The synthesis of planar sp2 -bonded system from molecular building blocks

    Science.gov (United States)

    Zhang, Xin; Luo, Hong; Gu, Gong

    Biphenyl and pyrene molecules were deposited onto atomically flat Cu (100) surface as building blocks for the synthesis of planar, conjugated, sp2-bonded system. In situ STM observation confirmed the formation of highly-ordered lattice structure after annealing under UHV condition, as a result of the substrate-assisted dehydrogenation. The electronic properties of the system were examined by STS and will be presented. ONR N00014-15-1-2661.

  10. Systemin/Jasmonate-Mediated Systemic Defense Signaling in Tomato

    Institute of Scientific and Technical Information of China (English)

    Jia-Qiang Sun; Hong-Ling Jiang; Chuan-You Li

    2011-01-01

    Wound-inducible proteinase inhibitors (Pis)in tomato plants provide a useful model system to elucidate the signal transduction pathways that regulate systemic defense response. Among the proposed intercellular signals for wound-induced Pis expression are the peptide systemin and the oxylipin-derived phytohormone jasmonic acid (JA).An increasing body of evidence indicates that systemin and JA work in the same signaling pathway to activate the ex-pression of Pis and other defense-related genes. However, relatively less is known about how these signals interact to promote cell-to-cell communication over long distances. Genetic analysis of the systemin/JA signaling pathway in tomato plants provides a unique opportunity to study, in a single experimental system, the mechanism by which peptide and oxylipin signals interact to coordinate systemic expression of defense-related genes. Previously, it has been proposed that systemin is the long-distance mobile signal for defense gene expression. Recently, grafting experiments with tomato mutants defective in JA biosynthesis and signaling provide new evidence that JA, rather than systemin, functions as the systemic wound signal, and that the biosynthesis of JA is regulated by the peptide systemin. Further understanding of the systemin/JA signaling pathway promises to provide new insights into the basic mechanisms governing plant de-fense to biotic stress.

  11. Performance Evaluation of Space-Time Turbo Code Concatenated With Block Code MC-CDMA Systems

    OpenAIRE

    Lokesh Kumar Bansal; Aditya Trivedi

    2011-01-01

    In this paper, performance of a space-time turbo code (STTuC) in concatenation with space-time block code (STBC) in multi-carrier code-division multiple-access (MCCDMA) system with multi-path fading channel is considered. The performance in terms of bit error rate (BER) is evaluated through simulations. The corresponding BER of the concatenated STTuC-STBC-MC-CDMA system is compared with STTuC-MC-CDMA system and STBC-MC-CDMA system. The simulation results show that the STTuC-MCCDMA system perf...

  12. Developing a synthetic signal transduction system in plants.

    Science.gov (United States)

    Morey, Kevin J; Antunes, Mauricio S; Albrecht, Kirk D; Bowen, Tessa A; Troupe, Jared F; Havens, Keira L; Medford, June I

    2011-01-01

    One area of focus in the emerging field of plant synthetic biology is the manipulation of systems involved in sensing and response to environmental signals. Sensing and responding to signals, including ligands, typically involves biological signal transduction. Plants use a wide variety of signaling systems to sense and respond to their environment. One of these systems, a histidine kinase (HK) based signaling system, lends itself to manipulation using the tools of synthetic biology. Both plants and bacteria use HKs to relay signals, which in bacteria can involve as few as two proteins (two-component systems or TCS). HK proteins are evolutionarily conserved between plants and bacteria and plant HK components have been shown to be functional in bacteria. We found that this conservation also applies to bacterial HK components which can function in plants. This conservation of function led us to hypothesize that synthetic HK signaling components can be designed and rapidly tested in bacteria. These novel HK signaling components form the foundation for a synthetic signaling system in plants, but typically require modifications such as codon optimization and proper targeting to allow optimal function. We describe the process and methodology of producing a synthetic signal transduction system in plants. We discovered that the bacterial response regulator (RR) PhoB shows HK-dependent nuclear translocation in planta. Using this discovery, we engineered a partial synthetic pathway in which a synthetic promoter (PlantPho) is activated using a plant-adapted PhoB (PhoB-VP64) and the endogenous HK-based cytokinin signaling pathway. Building on this work, we adapted an input or sensing system based on bacterial chemotactic binding proteins and HKs, resulting in a complete eukaryotic signal transduction system. Input to our eukaryotic signal transduction system is provided by a periplasmic binding protein (PBP), ribose-binding protein (RBP). RBP interacts with the membrane

  13. Signal amplification in a qubit-resonator system

    International Nuclear Information System (INIS)

    We study the dynamics of a qubit-resonator system, when the resonator is driven by two signals. The interaction of the qubit with the high-amplitude driving we consider in terms of the qubit dressed states. Interaction of the dressed qubit with the second probing signal can essentially change the amplitude of this signal. We calculate the transmission amplitude of the probe signal through the resonator as a function of the qubit energy and the driving frequency detuning. The regions of increase and attenuation of the transmitted signal are calculated and demonstrated graphically. We present the influence of the signal parameters on the value of the amplification, and discuss the values of the qubit-resonator system parameters for an optimal amplification and attenuation of the weak probe signal.

  14. Block Copolymer Modified Epoxy Amine System for Reactive Rotational Molding: Structures, Properties and Processability

    Science.gov (United States)

    Lecocq, Eva; Nony, Fabien; Tcharkhtchi, Abbas; Gérard, Jean-François

    2011-05-01

    Poly(styrene-butadiene-methylmethacrylate) (SBM) and poly(methylmethacrylate-butyle-acrylate-methylmethacrylate) (MAM) triblock copolymers have been dissolved in liquid DGEBA epoxy resin which is subsequently polymerized by meta-xylene diamine (MXDA) or Jeffamine EDR-148. A chemorheology study of these formulations by plate-plate rheology and by thermal analysis has allowed to conclude that the addition of these copolymer blocks improve the reactive rotational moulding processability without affecting the processing time. Indeed, it prevents the pooling of the formulation at the bottom of the mould and a too rapid build up of resin viscosity of these thermosetting systems. The morphology of the cured blends examined by scanning electron microscopy (SEM) shows an increase of fracture surface area and thereby a potential increase of the toughness with the modification of epoxy system. Dynamic mechanical spectroscopy (DMA) and opalescence of final material show that the block PMMA, initially miscible, is likely to induce phase separation from the epoxy-amine matrix. Thereby, the poor compatibilisation between the toughener and the matrix has a detrimental effect on the tensile mechanical properties. The compatibilisation has to be increased to improve in synergy the processability and the final properties of these block copolymer modified formulations. First attempts could be by adapting the length and ratio of each block.

  15. Utilization of excitation signal harmonics for control of nonlinear systems

    DEFF Research Database (Denmark)

    Vinther, Kasper; Rasmussen, Henrik; Izadi-Zamanabadi, Roozbeh; Stoustrup, Jakob

    signal together with Fourier analysis to generate a feedback signal and simulations have shown that different system gains and time constants does not change the global equilibrium/operating point. An evaporator in a refrigeration system was used as example in the simulations, however, it is anticipated...

  16. Adaptability of the Logistics System in National Economic Mobilization Based on Blocking Flow Theory

    Directory of Open Access Journals (Sweden)

    Xiangyuan Jing

    2014-01-01

    Full Text Available In the process of national economic mobilization, the logistics system usually suffers from negative impact and/or threats of such emergency events as wars and accidents, which implies that adaptability of the logistics system directly determines realization of economic mobilization. And where the real-time rescue operation is concerned, heavy traffic congestion is likely to cause a great loss of or damage to human beings and their properties. To deal with this situation, this article constructs a blocking-resistance optimum model and an optimum restructuring model based on blocking flow theories, of which both are illustrated by numerical cases and compared in characteristics and application. The design of these two models is expected to eliminate or alleviate the congestion situation occurring in the logistics system, thus effectively enhancing its adaptability in the national economic mobilization process.

  17. A novel image block cryptosystem based on a spatiotemporal chaotic system and a chaotic neural network

    International Nuclear Information System (INIS)

    In this paper, we propose a novel block cryptographic scheme based on a spatiotemporal chaotic system and a chaotic neural network (CNN). The employed CNN comprises a 4-neuron layer called a chaotic neuron layer (CNL), where the spatiotemporal chaotic system participates in generating its weight matrix and other parameters. The spatiotemporal chaotic system used in our scheme is the typical coupled map lattice (CML), which can be easily implemented in parallel by hardware. A 160-bit-long binary sequence is used to generate the initial conditions of the CML. The decryption process is symmetric relative to the encryption process. Theoretical analysis and experimental results prove that the block cryptosystem is secure and practical, and suitable for image encryption. (general)

  18. A novel image block cryptosystem based on a spatiotemporal chaotic system and a chaotic neural network

    Science.gov (United States)

    Wang, Xing-Yuan; Bao, Xue-Mei

    2013-05-01

    In this paper, we propose a novel block cryptographic scheme based on a spatiotemporal chaotic system and a chaotic neural network (CNN). The employed CNN comprises a 4-neuron layer called a chaotic neuron layer (CNL), where the spatiotemporal chaotic system participates in generating its weight matrix and other parameters. The spatiotemporal chaotic system used in our scheme is the typical coupled map lattice (CML), which can be easily implemented in parallel by hardware. A 160-bit-long binary sequence is used to generate the initial conditions of the CML. The decryption process is symmetric relative to the encryption process. Theoretical analysis and experimental results prove that the block cryptosystem is secure and practical, and suitable for image encryption.

  19. Low-Overhead Non-Blocking Checkpointing Scheme for Mobile Computing Systems

    Institute of Scientific and Technical Information of China (English)

    MEN Chaoguang; CAO Liujuan; WANG Liwen; XU Zhenpeng

    2007-01-01

    When applied to mobile computing systems, checkpoint protocols for distributed computing systems would face many new challenges, such as low wireless bandwidth, frequent disconnections, and lack of stable storage at mobile hosts. This paper proposes a novel checkpoint protocol to effectively reduce the coordinating overhead. By using a communication vector, only a few processes participate in the checkpointing event. During checkpointing, the scheme can save the time used to trace the dependency tree by sending checkpoint requests to dependent processes at once. In addition, processes are non-blocking in this scheme, since the inconsistency is resolved by the piggyback technique. Hence the unnecessary and orphan messages can be avoided. Compared with the traditional coordinated checkpoint approach, the proposed non-blocking algorithm obtains a minimal number of processes to take checkpoints. It also reduces the checkpoint latency, which brings less overhead to mobile host with limited resources.

  20. Novel pH or thermosensitive block copolymers for triggered drug-delivery systems

    OpenAIRE

    Jérôme, Christine

    2007-01-01

    Over the last decade, polymer micelles and nanoparticles have attracted an increasing interest as efficient drug delivery systems. Polymer micelles from amphiphilic block copolymers are supramolecular core-shell type assemblies of some tens of nanometers in diameter. They are highly stable in aqueous solution because of their low intrinsic critical micelle concentration, which prevents their dissociation upon dilution in the blood stream after intravenous injection. The combination of poly(e...

  1. Security Analysis of a Block Encryption Algorithm Based on Dynamic Sequences of Multiple Chaotic Systems

    Institute of Scientific and Technical Information of China (English)

    DU Mao-Kang; HE Bo; WANG Yong

    2011-01-01

    Recently, the cryptosystem based on chaos has attracted much attention. Wang and Yu (Commun. Nonlin. Sci. Numer. Simulat. 14(2009)574) proposed a block encryption algorithm based on dynamic sequences of multiple chaotic systems. We analyze the potential Saws in the algorithm. Then, a chosen-plaintext attack is presented. Some remedial measures are suggested to avoid the flaws effectively. Furthermore, an improved encryption algorithm is proposed to resist the attacks and to keep all the merits of the original cryptosystem.

  2. A Fully Implanted Drug Delivery System for Peripheral Nerve Blocks in Behaving Animals

    OpenAIRE

    Pohlmeyer, Eric A; Jordon, Luke R.; Kim, Peter; Miller, Lee E.

    2009-01-01

    Inhibiting peripheral nerve function can be useful for many studies of the nervous system or motor control. Accomplishing this in a temporary fashion in animal models by using peripheral nerve blocks permits studies of the immediate effects of the loss, and/or any resulting short-term changes and adaptations in behavior or motor control, while avoiding the complications commonly associated with permanent lesions, such as sores or self-mutilation. We have developed a method of quickly and repe...

  3. Prototypic implementations of the building block for component based open Hypermedia systems (BB/CB-OHSs)

    DEFF Research Database (Denmark)

    Mohamed, Omer I. Eldai

    2005-01-01

    In this paper we describe the prototypic implementations of the BuildingBlock (BB/CB-OHSs) that proposed to address some of the Component-based Open Hypermedia Systems (CB-OHSs) issues, including distribution and interoperability [4, 11, 12]. Four service implementations were described below. The....... These are the math service, navigational service, naming and location service and the storage service in addition to two communication protocols (TCP/IP and JAVA RMI)....

  4. Evaluated phase diagrams of binary metal-tellurium systems of the D-block transition elements

    International Nuclear Information System (INIS)

    The binary phase diagrams of metal-tellurium systems for twenty seven d-block transition elements have been critically evaluated. Complete phase diagrams are presented for the elements, chromium, manganese, iron, cobalt, nickel, copper, molybdenum, palladium, silver, lanthanum, platinum and gold, whereas, for scandium, titanium, vanadium, yttrium, zirconium, niobium, technitium, ruthenium, rhodium, hafnium, tantalum, tungsten , rhenium, osmium and iridium, the phase diagrams are incomplete and tentative. (author). 20 refs., 27 tabs., 27 figs

  5. Signals, processes, and systems an interactive multimedia introduction to signal processing

    CERN Document Server

    Karrenberg, Ulrich

    2013-01-01

    This is a very new concept for learning Signal Processing, not only from the physically-based scientific fundamentals, but also from the didactic perspective, based on modern results of brain research. The textbook together with the DVD form a learning system that provides investigative studies and enables the reader to interactively visualize even complex processes. The unique didactic concept is built on visualizing signals and processes on the one hand, and on graphical programming of signal processing systems on the other. The concept has been designed especially for microelectronics, computer technology and communication. The book allows to develop, modify, and optimize useful applications using DasyLab - a professional and globally supported software for metrology and control engineering. With the 3rd edition, the software is also suitable for 64 bit systems running on Windows 7. Real signals can be acquired, processed and played on the sound card of your computer. The book provides more than 200 pre-pr...

  6. Goldstone solar system radar signal processing

    Science.gov (United States)

    Jurgens, R. F.; Satorius, E.; Sanchez, O.

    1992-01-01

    A performance analysis of the planetary radar data acquisition system is presented. These results extend previous computer simulation analysis and are facilitated by the development of a simple analytical model that predicts radar system performance over a wide range of operational parameters. The results of this study are useful to both the radar systems designer and the science investigator in establishing operational radar data acquisition parameters which result in the best systems performance for a given set of input conditions.

  7. COMPUTER-BASED ECG SIGNAL ANALYSIS AND MONITORING SYSTEM

    Directory of Open Access Journals (Sweden)

    Nasser N. Khamiss Al-Ani

    2008-01-01

    Full Text Available This paper deals with the design and implementation of an ECG system. The proposed system gives a new concept of ECG signal manipulation, storing, and editing. It consists mainly of hardware circuits and the related software. The hardware includes the circuits of ECG signals capturing, and system interfaces. The software is written using Visual Basic languages, to perform the task of identification of the ECG signal. The main advantage of the system is to provide a reported ECG recording on a personal computer, so that it can be stored and processed at any time as required. This system was tested for different ECG signals, some of them are abnormal and the other is normal, and the results show that the system has a good quality of diagnosis identification.

  8. Signal processing methods for PWR reactor noise diagnostic system

    International Nuclear Information System (INIS)

    A framework for a PWR reactor noise diagnostic system using various signal processing methods has been investigated. Supposing to treat not only reactor noise data in a stationary linear system but also those in a nonstationary or nonlinear system, the study covers a third-order-correlation of bispectrum, cepstrum analysis, Group Method of Data Handling (GMDH), chaotic quantity, neural network, and wavelet, in addition to Multivariate AutoRegressive analysis and Signal Transmission Path Diagram analysis (MAR/STPD). This paper describes consideration about the methods from viewpoints of theories and applications to PWR reactor noise diagnostic system. The point at the issue in the application system is how to extract many characteristics from the signals whatever states (linear or nonlinear, stationary or nonstationary) may happen in order to get more information and more exact diagnose to support human judgment. From this viewpoint, the paper discusses several signal processing techniques for the PWR diagnostic system. (J.P.N.)

  9. Developing the basic building blocks of mathematics to be employed in practical embedded systems

    International Nuclear Information System (INIS)

    Mathematics is vitally important as it is used in many areas of science and engineering, in particular are functions such as sine, cosine and the exponent in addition to being to able to carry out such tasks as decimal division. The sine wave is vitally important in physics and communications due to its ability to retain its waveshape when added to another sine wave of the same frequency and arbitrary phase. It is the only periodic waveform that has this property and leads to techniques such as Fourier analysis. Unfortunately these blocks are not included in the standard DSP Builder blockset in Simulink and so a method of creating these operations must be created if this methodology is to be employed in real world tasks such as power relay protection and stereo vision systems. Shown here is a method of performing these calculations using the limited blocks provided for a 50-bit based embedded system with a discussion about the accuracy when compared to traditional digital system counterparts. The order of the equations used and the scaling factors of the blocks are investigated to provide evidence of why certain values need to be changed depending upon the calculation being performed.

  10. Theory for dynamical self arrest and gelation in microemulsions and the block copolymer systems

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Sangwook

    2005-05-01

    The main purpose of this work is to investigate the glassy behavior of microemulsions and block copolymers. The origin of glassy behavior in microemulsions and block copolymers is frustration due to a competition between short-range interaction and long range interaction. According to the charge frustrated Ising model, the competition between ferromagnetic interaction and antiferromagnetic interaction is the origin of frustration in microemulsions. The competition between entropic effects and stoichiometric constraints responsible for the formation of micelles in microemulsions can lead to the emergence of a self generated glassy behavior in these systems. In the block copolymer, the competition between the repulsive short range interaction between monomers in polymer chains and the long range interaction by chemical bonds can lead to the emergence of a self generated glassy behavior. The criteria for the fluctuation induced first order transition and our microemulsion and block copolymer glasses are essentially the same. Both are a consequence of the large phase space of low energy excitations (14) (62) (all states with momenta q which fulfill |q| = q{sub m}) and are of at the most a moderate supercooling of the liquid state is required. This is strongly supported by the observation in Ref. (14) that the metastable states which are first to appear at a fluctuation induced first order transition are the ones build by a superposition of large amplitude waves of wavenumber q{sub m}, but with random orientations and phases, i.e. just the ones which form the metastable states of our microemulsion and block copolymer glass. (38)

  11. Ground standoff mine detection system (GSTAMIDS) engineering, manufacturing, and development (EMD) Block 0

    Science.gov (United States)

    Pressley, Jackson R.; Pabst, Donald; Sower, Gary D.; Nee, Larry; Green, Brian; Howard, Peter

    2001-10-01

    The United States Army has contracted EG&G Technical Services to build the GSTAMIDS EMD Block 0. This system autonomously detects and marks buried anti-tank land mines from an unmanned vehicle. It consists of a remotely operated host vehicle, standard teleoperation system (STS) control, mine detection system (MDS) and a control vehicle. Two complete systems are being fabricated, along with a third MDS. The host vehicle for Block 0 is the South African Meerkat that has overpass capability for anti-tank mines, as well as armor anti-mine blast protection and ballistic protection. It is operated via the STS radio link from within the control vehicle. The Main Computer System (MCS), located in the control vehicle, receives sensor data from the MDS via a high speed radio link, processes and fuses the data to make a decision of a mine detection, and sends the information back to the host vehicle for a mark to be placed on the mine location. The MCS also has the capability to interface into the FBCB2 system via SINGARS radio. The GSTAMIDS operator station and the control vehicle communications system also connect to the MCS. The MDS sensors are mounted on the host vehicle and include Ground Penetrating Radar (GPR), Pulsed Magnetic Induction (PMI) metal detector, and (as an option) long-wave infrared (LWIR). A distributed processing architecture is used so that pre-processing is performed on data at the sensor level before transmission to the MCS, minimizing required throughput. Nine (9) channels each of GPR and PMI are mounted underneath the meerkat to provide a three-meter detection swath. Two IR cameras are mounted on the upper sides of the Meerkat, providing a field of view of the required swath with overlap underneath the vehicle. Also included on the host vehicle are an Internal Navigation System (INS), Global Positioning System (GPS), and radio communications for remote control and data transmission. The GSTAMIDS Block 0 is designed as a modular, expandable system

  12. Signal processing method and system for noise removal and signal extraction

    Science.gov (United States)

    Fu, Chi Yung; Petrich, Loren

    2009-04-14

    A signal processing method and system combining smooth level wavelet pre-processing together with artificial neural networks all in the wavelet domain for signal denoising and extraction. Upon receiving a signal corrupted with noise, an n-level decomposition of the signal is performed using a discrete wavelet transform to produce a smooth component and a rough component for each decomposition level. The n.sup.th level smooth component is then inputted into a corresponding neural network pre-trained to filter out noise in that component by pattern recognition in the wavelet domain. Additional rough components, beginning at the highest level, may also be retained and inputted into corresponding neural networks pre-trained to filter out noise in those components also by pattern recognition in the wavelet domain. In any case, an inverse discrete wavelet transform is performed on the combined output from all the neural networks to recover a clean signal back in the time domain.

  13. Measurement System for Playout Delay of TV Signals

    NARCIS (Netherlands)

    Kooij, W.J.; Stokking, H.M.; Brandenburg, R. van; Boer, P.T. de

    2014-01-01

    TV signals are carried towards end-users using different (broadcast) technologies and by different providers. This is causing differences in the playout timing of the TV signal at different locations and devices. Authors have developed a measurement system for measuring the relative playout delay of

  14. Power system small signal stability analysis and control

    CERN Document Server

    Mondal, Debasish; Sengupta, Aparajita

    2014-01-01

    Power System Small Signal Stability Analysis and Control presents a detailed analysis of the problem of severe outages due to the sustained growth of small signal oscillations in modern interconnected power systems. The ever-expanding nature of power systems and the rapid upgrade to smart grid technologies call for the implementation of robust and optimal controls. Power systems that are forced to operate close to their stability limit have resulted in the use of control devices by utility companies to improve the performance of the transmission system against commonly occurring power system

  15. Block Krylov subspace exact time integration of linear ODE systems. Part 1: algorithm description

    CERN Document Server

    Botchev, Mikhail A

    2011-01-01

    We propose a time-exact Krylov-subspace-based method for solving linear ODE (ordinary differential equation) systems of the form $y'=-Ay + g(t)$, where $y(t)$ is the unknown function. The method consists of two stages. The first stage is an accurate polynomial approximation of the source term $g(t)$, constructed with the help of the truncated SVD (singular value decomposition). The second stage is a special residual-based block Krylov subspace method. The accuracy of the method is only restricted by the accuracy of the polynomial approximation and by the error of the block Krylov process. Since both errors can, in principle, be made arbitrarily small, this yields, at some costs, a time-exact method.

  16. Block preconditioners for linear systems arising from multiscale collocation with compactly supported RBFs

    KAUST Repository

    Farrell, Patricio

    2015-04-30

    © 2015John Wiley & Sons, Ltd. Symmetric collocation methods with RBFs allow approximation of the solution of a partial differential equation, even if the right-hand side is only known at scattered data points, without needing to generate a grid. However, the benefit of a guaranteed symmetric positive definite block system comes at a high computational cost. This cost can be alleviated somewhat by considering compactly supported RBFs and a multiscale technique. But the condition number and sparsity will still deteriorate with the number of data points. Therefore, we study certain block diagonal and triangular preconditioners. We investigate ideal preconditioners and determine the spectra of the preconditioned matrices before proposing more practical preconditioners based on a restricted additive Schwarz method with coarse grid correction. Numerical results verify the effectiveness of the preconditioners.

  17. Selective gas transfer through binary polymeric systems based on block-copolymers.

    Science.gov (United States)

    Beckman, I N; Teplyakov, V V

    2015-08-01

    Evaluation of several versions of phenomenological theory of gas permeability in selective polymeric membranes is presented, along with the appropriate experimental methods for verification of these versions. The main focus is on a description of stationary mass transfer across membranes (films) containing dispersion inclusions of various shapes of one polymer in a matrix of another. Considering heterogeneous media as a membrane material, it was assumed that diffusion and sorption properties of inclusions are different from those of the dispersing medium. The problem of choosing optimal shape of inclusions is evaluated from the point of view of targeted permeability and selectivity of a membrane with respect to gases. To confirm this theoretical approach, the experimental results of the studies of diffusion (permeability) of permanent gases in polymeric membranes of different structures were used. The target gases included noble gases, hydrogen, nitrogen, oxygen, CO2, and methane. The target polymers included glassy polyvinyltrimethylsilane (PVTMS, T(gl)=155-180 °C), rubberlike polydimethylsiloxane (PDMS, T(gl)=-120 °C), and two-phase block-copolymers based on these materials within a wide range of composition, including the region of phase inversion. In addition, available experimental literature data on gas permeation parameters for polyarylat-polysiloxane, polysulfon-polysiloxane, and polycarbonate-polysiloxane block-copolymers are utilized. In order to describe the stationary gas permeability for two-phase systems (from diluted dispersion of one polymer in another to concentrated dispersion and complete phase inversion) the empiric approaches based on modified Maxwell equations are offered. The requirements for two-phase systems with high permeability and selectivity parameters for gas separation are identified. The permeability parameters are predicted for C1-C4 hydrocarbons in block-copolymers based on PDMS dispersion in PVTMS, phase inversion, and PVTMS

  18. Improvement of train transportation performance by convoy signaling

    Science.gov (United States)

    Zhao, Yingbo; Orlik, Philip; Parsons, Kieran; Kataoka, Kenji; Kalmar-Nagy, Tamas

    2016-02-01

    In this paper, we compare the transportation performance of a given railway for three types of signaling system: fixed-block signaling, moving-block signaling and train-convoy signaling. The transportation performance is evaluated from two aspects: track capacity and robustness to delays. The transportation performance is computed using numerical method and a new cellular automaton model is proposed to simulate the behavior of a train. The simulation results show that train-convoy signaling can improve track capacity and robustness to delays, at the same time, compared to fixed-block signaling and moving-block signaling.

  19. Immune System to Brain Signaling: Neuropsychopharmacological Implications

    OpenAIRE

    Capuron, Lucile; Miller, Andrew H.

    2011-01-01

    There has been an explosion in our knowledge of the pathways and mechanisms by which the immune system can influence the brain and behavior. In the context of inflammation, pro-inflammatory cytokines can access the central nervous system and interact with a cytokine network in the brain to influence virtually every aspect of brain function relevant to behavior including neurotransmitter metabolism, neuroendocrine function, synaptic plasticity, and neurocircuits that regulate mood, motor activ...

  20. A new UHV system for channeling/blocking analysis of solid surfaces and interfaces

    International Nuclear Information System (INIS)

    This paper describes principles, design and tests of a new UHV system for structural analysis of solid surfaces and interfaces with medium energy ion scattering (50-500 keV H+ or He+), combined with channeling and blocking. The chamber contains a high precision, three-axis manipulator for accurate alignment of samples under investigation and a toroidal electrostatic analyser for simultaneous energy selection and angular detection of reflected ions over a range of scattering angles of 300. With a sample loading chamber containing up to seven samples, samples can be transferred to the manipulator without breaking the vacuum of the main system. (orig.)

  1. Block Structured Adaptive Mesh and Time Refinement for Hybrid, Hyperbolic + N-body Systems

    CERN Document Server

    Miniati, F; Miniati, Francesco; Colella, Phillip

    2006-01-01

    We present a new numerical algorithm for the solution of coupled collisional and collisionless systems, based on the block structured adaptive mesh and time refinement strategy (AMR). We describe the issues associated with the discretization of the system equations and the synchronization of the numerical solution on the hierarchy of grid levels. We implement a code based on a higher order, conservative and directionally unsplit Godunov method for hydrodynamics; a symmetric, time centered modified symplectic scheme for collisionless component; and a multilevel, multigrid relaxation algorithm for the elliptic equation coupling the two components. Numerical results that illustrate the accuracy of the code and the relative merit of various implemented schemes are also presented.

  2. An implantable CMOS signal conditioning system for recording nerve signals with cuff electrodes

    DEFF Research Database (Denmark)

    Papathanasiou, Konstantinos; Lehmann, Torsten

    2000-01-01

    We propose a system architecture for recording nerve signals with cuff electrodes and develop the key component in this system, the small-input, low-noise, low-power, high-gain amplifier. The amplifier is implemented using a mixture of weak- and strong-inversion transistors and a special off...

  3. Secure transmission of images based on chaotic systems and cipher block chaining

    Science.gov (United States)

    Lakhani, Mahdieh Karimi; Behnam, Hamid; Karimi, Arash

    2013-01-01

    The ever-growing penetration of communication networks, digital and Internet technologies in our everyday lives has the transmission of text data, as well as multimedia data such as images and videos, possible. Digital images have a vast usage in a number of applications, including medicine and providing security authentication, for example. This applicability becomes evident when images, such as walking or people's facial features, are utilized in their identification. Considering the required security level and the properties of images, different algorithms may be used. After key generation using logistic chaos signals, a scrambling function is utilized for image agitation in both horizontal and vertical axes, and then a block-chaining mode of operation may be applied to encrypt the resultant image. The results demonstrate that using the proposed method drastically degrades the correlation between the image components and also the entropy is increased to an acceptable level. Therefore, the image will become greatly resistant to differential attacks. However, the increasing scrambling rounds and the decreasing number of bits of the blocks result in increasing the entropy and decreasing the correlation.

  4. The BTK Inhibitor Ibrutinib (PCI-32765) Blocks Hairy Cell Leukaemia Survival, Proliferation and BCR Signalling: A New Therapeutic Approach

    OpenAIRE

    Sivina, Mariela; Kreitman, Robert J.; Arons, Evgeny; Ravandi, Farhad; Burger, Jan A.

    2014-01-01

    B cell receptor (BCR) signalling plays a critical role in the progression of several B-cell malignancies, but its role in hairy cell leukaemia (HCL) is ambiguous. Bruton tyrosine kinase (BTK), a key player in BCR signalling, migration and adhesion, can be targeted with ibrutinib, a selective, irreversible BTK inhibitor. We analysed BTK expression and function in HCL and analysed the effects of ibrutinib on HCL cells. We demonstrated uniform BTK protein expression in HCL cells. Ibrutinib signi...

  5. mTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling

    OpenAIRE

    Zhang, Huiyuan; Dou, Jun; Yu, Yang; Zhao, Yanling; Fan, Yihui; Cheng, Jin; Xu, Xin; Liu, Wei; Guan, Shan; Chen, Zhenghu; Shi, Yan; Patel, Roma; Vasudevan, Sanjeev A.; Zage, Peter E; Zhang, Hong

    2015-01-01

    High-risk neuroblastoma often develops resistance to high-dose chemotherapy. The mTOR signaling cascade is frequently deregulated in human cancers and targeting mTOR signaling sensitizes many cancer types to chemotherapy. Here, using a panel of neuroblastoma cell lines, we found that the mTOR inhibitor INK128 showed inhibitory effects on both anchorage-dependent and independent growth of neuroblastoma cells and significantly enhanced the cytotoxic effects of doxorubicin (Dox) on these cell li...

  6. Targeting the PDGF-B/PDGFR-β Interface with Destruxin A5 to Selectively Block PDGF-BB/PDGFR-ββ Signaling and Attenuate Liver Fibrosis

    Directory of Open Access Journals (Sweden)

    Xingqi Wang

    2016-05-01

    Full Text Available PDGF-BB/PDGFR-ββ signaling plays very crucial roles in the process of many diseases such as liver fibrosis. However, drug candidates with selective affinities for PDGF-B/PDGFR-β remain deficient. Here, we identified a natural cyclopeptide termed destruxin A5 that effectively inhibits PDGF-BB-induced PDGFR-β signaling. Interestingly and importantly, the inhibitory mechanism is distinct from the mechanism of tyrosine kinase inhibitors because destruxin A5 does not have the ability to bind to the ATP-binding pocket of PDGFR-β. Using Biacore T200 technology, thermal shift technology, microscale thermophoresis technology and computational analysis, we confirmed that destruxin A5 selectively targets the PDGF-B/PDGFR-β interaction interface to block this signaling. Additionally, the inhibitory effect of destruxin A5 on PDGF-BB/PDGFR-ββ signaling was verified using in vitro, ex vivo and in vivo models, in which the extent of liver fibrosis was effectively alleviated by destruxin A5. In summary, destruxin A5 may represent an efficacious and more selective inhibitor of PDGF-BB/PDGFR-ββ signaling.

  7. The design and implementation of signal decomposition system of CL multi-wavelet transform based on DSP builder

    Science.gov (United States)

    Huang, Yan; Wang, Zhihui

    2015-12-01

    With the development of FPGA, DSP Builder is widely applied to design system-level algorithms. The algorithm of CL multi-wavelet is more advanced and effective than scalar wavelets in processing signal decomposition. Thus, a system of CL multi-wavelet based on DSP Builder is designed for the first time in this paper. The system mainly contains three parts: a pre-filtering subsystem, a one-level decomposition subsystem and a two-level decomposition subsystem. It can be converted into hardware language VHDL by the Signal Complier block that can be used in Quartus II. After analyzing the energy indicator, it shows that this system outperforms Daubenchies wavelet in signal decomposition. Furthermore, it has proved to be suitable for the implementation of signal fusion based on SoPC hardware, and it will become a solid foundation in this new field.

  8. Estimating parameters of chaotic systems synchronized by external driving signal

    Energy Technology Data Exchange (ETDEWEB)

    Wu Xiaogang [Institute of PR and AI, Huazhong University of Science and Technology, Wuhan 430074 (China)]. E-mail: seanwoo@mail.hust.edu.cn; Wang Zuxi [Institute of PR and AI, Huazhong University of Science and Technology, Wuhan 430074 (China)

    2007-07-15

    Noise-induced synchronization (NIS) has evoked great research interests recently. Two uncoupled identical chaotic systems can achieve complete synchronization (CS) by feeding a common noise with appropriate intensity. Actually, NIS belongs to the category of external feedback control (EFC). The significance of applying EFC in secure communication lies in fact that the trajectory of chaotic systems is disturbed so strongly by external driving signal that phase space reconstruction attack fails. In this paper, however, we propose an approach that can accurately estimate the parameters of the chaotic systems synchronized by external driving signal through chaotic transmitted signal, driving signal and their derivatives. Numerical simulation indicates that this approach can estimate system parameters and external coupling strength under two driving modes in a very rapid manner, which implies that EFC is not superior to other methods in secure communication.

  9. Estimating parameters of chaotic systems synchronized by external driving signal

    International Nuclear Information System (INIS)

    Noise-induced synchronization (NIS) has evoked great research interests recently. Two uncoupled identical chaotic systems can achieve complete synchronization (CS) by feeding a common noise with appropriate intensity. Actually, NIS belongs to the category of external feedback control (EFC). The significance of applying EFC in secure communication lies in fact that the trajectory of chaotic systems is disturbed so strongly by external driving signal that phase space reconstruction attack fails. In this paper, however, we propose an approach that can accurately estimate the parameters of the chaotic systems synchronized by external driving signal through chaotic transmitted signal, driving signal and their derivatives. Numerical simulation indicates that this approach can estimate system parameters and external coupling strength under two driving modes in a very rapid manner, which implies that EFC is not superior to other methods in secure communication

  10. Biometric recognition system using low bandwidth ECG signals

    OpenAIRE

    Matos, André Cigarro; Lourenço, André Ribeiro; Nascimento, José M. P.

    2013-01-01

    Biometric recognition has recently emerged as part of applications where the privacy of the information is crucial, as in the health care field. This paper presents a biometric recognition system based on the Electrocardiographic signal (ECG). The proposed system is based on a state-of-the-art recognition method which extracts information from the frequency domain. In this paper we propose a new method to increase the spectral resolution of low bandwidth ECG signals due to the limited bandwid...

  11. 4th International Conference on Communications, Signal Processing, and Systems

    CERN Document Server

    Mu, Jiasong; Wang, Wei; Zhang, Baoju

    2016-01-01

    This book brings together papers presented at the 4th International Conference on Communications, Signal Processing, and Systems, which provides a venue to disseminate the latest developments and to discuss the interactions and links between these multidisciplinary fields. Spanning topics ranging from Communications, Signal Processing and Systems, this book is aimed at undergraduate and graduate students in Electrical Engineering, Computer Science and Mathematics, researchers and engineers from academia and industry as well as government employees (such as NSF, DOD, DOE, etc).

  12. OUTPUT FEEDBACK CONTROL FOR MIMO NONLINEAR SYSTEMS WITH EXOGENOUS SIGNALS

    Institute of Scientific and Technical Information of China (English)

    Ying ZHOU; Yuqiang WU

    2006-01-01

    The paper addresses the global output tracking of a class of multi-input multi-output(MIMO) nonlinear systems affected by disturbances, which are generated by a known exosystem. An adaptive controller is designed based on the proposed observer and the backstepping approach to asymptotically track arbitrary reference signal and to guarantee the boundedness of all the signals in the closed loop system. Finally, the numerical simulation results illustrate the effectiveness of the proposed scheme.

  13. Digital signal processing in power system protection and control

    CERN Document Server

    Rebizant, Waldemar; Wiszniewski, Andrzej

    2011-01-01

    Digital Signal Processing in Power System Protection and Control bridges the gap between the theory of protection and control and the practical applications of protection equipment. Understanding how protection functions is crucial not only for equipment developers and manufacturers, but also for their users who need to install, set and operate the protection devices in an appropriate manner. After introductory chapters related to protection technology and functions, Digital Signal Processing in Power System Protection and Control presents the digital algorithms for signal filtering, followed

  14. BLOCK CODING SCHEME FOR REDUCING PAPR IN OFDM SYSTEMS WITH LARGE NUMBER OF SUBCARRIERS

    Institute of Scientific and Technical Information of China (English)

    Jiang Tao; Zhu Guangxi; Zheng Jianbin

    2004-01-01

    The major drawback in Orthogonal Frequency Division Multiplexing (OFDM) system is due to the high Peak-to-Average Power Ratio (PAPR), so the performance of the system is significantly degraded by the nonlinearity of a High Power Amplifier (HPA) in the transmitter.In order to mitigate distortion, a block coding scheme for reducing PAPR in OFDM systems with large number of subcarriers based on complementary sequences and predistortion is proposed,which is capable of both error correction and PAPR reduction. Computer simulation results show that the proposed scheme significantly improves Bit Error Rate(BER) performance as compared to an uncoded system when an HPA is employed or a coded system without predistortion.

  15. Emergency vehicle traffic signal preemption system

    Science.gov (United States)

    Bachelder, Aaron D. (Inventor); Foster, Conrad F. (Inventor)

    2011-01-01

    An emergency vehicle traffic light preemption system for preemption of traffic lights at an intersection to allow safe passage of emergency vehicles. The system includes a real-time status monitor of an intersection which is relayed to a control module for transmission to emergency vehicles as well as to a central dispatch office. The system also provides for audio warnings at an intersection to protect pedestrians who may not be in a position to see visual warnings or for various reasons cannot hear the approach of emergency vehicles. A transponder mounted on an emergency vehicle provides autonomous control so the vehicle operator can attend to getting to an emergency and not be concerned with the operation of the system. Activation of a priority-code (i.e. Code-3) situation provides communications with each intersection being approached by an emergency vehicle and indicates whether the intersection is preempted or if there is any conflict with other approaching emergency vehicles. On-board diagnostics handle various information including heading, speed, and acceleration sent to a control module which is transmitted to an intersection and which also simultaneously receives information regarding the status of an intersection. Real-time communications and operations software allow central and remote monitoring, logging, and command of intersections and vehicles.

  16. Curcumin blocks interleukin (IL)-2 signaling in T-lymphocytes by inhibiting IL-2 synthesis, CD25 expression, and IL-2 receptor signaling

    Energy Technology Data Exchange (ETDEWEB)

    Forward, Nicholas A.; Conrad, David M. [Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia (Canada); Power Coombs, Melanie R.; Doucette, Carolyn D. [Department of Pathology, Dalhousie University, Halifax, Nova Scotia (Canada); Furlong, Suzanne J. [Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia (Canada); Lin, Tong-Jun [Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia (Canada); Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia (Canada); Hoskin, David W., E-mail: d.w.hoskin@dal.ca [Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia (Canada); Department of Pathology, Dalhousie University, Halifax, Nova Scotia (Canada); Department of Surgery, Dalhousie University, Halifax, Nova Scotia (Canada)

    2011-04-22

    Highlights: {yields} Curcumin inhibits CD4{sup +} T-lymphocyte proliferation. {yields} Curcumin inhibits interleukin-2 (IL-2) synthesis and CD25 expression by CD4{sup +} T-lymphocytes. {yields} Curcumin interferes with IL-2 receptor signaling by inhibiting JAK3 and STAT5 phosphorylation. {yields} IL-2-dependent regulatory T-lymphocyte function and Foxp3 expression is downregulated by curcumin. -- Abstract: Curcumin (diferulomethane) is the principal curcuminoid in the spice tumeric and a potent inhibitor of activation-induced T-lymphocyte proliferation; however, the molecular basis of this immunosuppressive effect has not been well studied. Here we show that micromolar concentrations of curcumin inhibited DNA synthesis by mouse CD4{sup +} T-lymphocytes, as well as interleukin-2 (IL-2) and CD25 ({alpha} chain of the high affinity IL-2 receptor) expression in response to antibody-mediated cross-linking of CD3 and CD28. Curcumin acted downstream of protein kinase C activation and intracellular Ca{sup 2+} release to inhibit I{kappa}B phosphorylation, which is required for nuclear translocation of the transcription factor NF{kappa}B. In addition, IL-2-dependent DNA synthesis by mouse CTLL-2 cells, but not constitutive CD25 expression, was impaired in the presence of curcumin, which demonstrated an inhibitory effect on IL-2 receptor (IL-2R) signaling. IL-2-induced phosphorylation of STAT5A and JAK3, but not JAK1, was diminished in the presence of curcumin, indicating inhibition of critical proximal events in IL-2R signaling. In line with the inhibitory action of curcumin on IL-2R signaling, pretreatment of CD4{sup +}CD25{sup +} regulatory T-cells with curcumin downregulated suppressor function, as well as forkhead box p3 (Foxp3) expression. We conclude that curcumin inhibits IL-2 signaling by reducing available IL-2 and high affinity IL-2R, as well as interfering with IL-2R signaling.

  17. Curcumin blocks interleukin (IL)-2 signaling in T-lymphocytes by inhibiting IL-2 synthesis, CD25 expression, and IL-2 receptor signaling

    International Nuclear Information System (INIS)

    Highlights: → Curcumin inhibits CD4+ T-lymphocyte proliferation. → Curcumin inhibits interleukin-2 (IL-2) synthesis and CD25 expression by CD4+ T-lymphocytes. → Curcumin interferes with IL-2 receptor signaling by inhibiting JAK3 and STAT5 phosphorylation. → IL-2-dependent regulatory T-lymphocyte function and Foxp3 expression is downregulated by curcumin. -- Abstract: Curcumin (diferulomethane) is the principal curcuminoid in the spice tumeric and a potent inhibitor of activation-induced T-lymphocyte proliferation; however, the molecular basis of this immunosuppressive effect has not been well studied. Here we show that micromolar concentrations of curcumin inhibited DNA synthesis by mouse CD4+ T-lymphocytes, as well as interleukin-2 (IL-2) and CD25 (α chain of the high affinity IL-2 receptor) expression in response to antibody-mediated cross-linking of CD3 and CD28. Curcumin acted downstream of protein kinase C activation and intracellular Ca2+ release to inhibit IκB phosphorylation, which is required for nuclear translocation of the transcription factor NFκB. In addition, IL-2-dependent DNA synthesis by mouse CTLL-2 cells, but not constitutive CD25 expression, was impaired in the presence of curcumin, which demonstrated an inhibitory effect on IL-2 receptor (IL-2R) signaling. IL-2-induced phosphorylation of STAT5A and JAK3, but not JAK1, was diminished in the presence of curcumin, indicating inhibition of critical proximal events in IL-2R signaling. In line with the inhibitory action of curcumin on IL-2R signaling, pretreatment of CD4+CD25+ regulatory T-cells with curcumin downregulated suppressor function, as well as forkhead box p3 (Foxp3) expression. We conclude that curcumin inhibits IL-2 signaling by reducing available IL-2 and high affinity IL-2R, as well as interfering with IL-2R signaling.

  18. Early warning signals of tipping points in periodically forced systems

    Science.gov (United States)

    Williamson, Mark S.; Bathiany, Sebastian; Lenton, Timothy M.

    2016-04-01

    The prospect of finding generic early warning signals of an approaching tipping point in a complex system has generated much interest recently. Existing methods are predicated on a separation of timescales between the system studied and its forcing. However, many systems, including several candidate tipping elements in the climate system, are forced periodically at a timescale comparable to their internal dynamics. Here we use alternative early warning signals of tipping points due to local bifurcations in systems subjected to periodic forcing whose timescale is similar to the period of the forcing. These systems are not in, or close to, a fixed point. Instead their steady state is described by a periodic attractor. For these systems, phase lag and amplification of the system response can provide early warning signals, based on a linear dynamics approximation. Furthermore, the Fourier spectrum of the system's time series reveals harmonics of the forcing period in the system response whose amplitude is related to how nonlinear the system's response is becoming with nonlinear effects becoming more prominent closer to a bifurcation. We apply these indicators as well as a return map analysis to a simple conceptual system and satellite observations of Arctic sea ice area, the latter conjectured to have a bifurcation type tipping point. We find no detectable signal of the Arctic sea ice approaching a local bifurcation.

  19. An innovative nonintrusive driver assistance system for vital signal monitoring.

    Science.gov (United States)

    Sun, Ye; Yu, Xiong Bill

    2014-11-01

    This paper describes an in-vehicle nonintrusive biopotential measurement system for driver health monitoring and fatigue detection. Previous research has found that the physiological signals including eye features, electrocardiography (ECG), electroencephalography (EEG) and their secondary parameters such as heart rate and HR variability are good indicators of health state as well as driver fatigue. A conventional biopotential measurement system requires the electrodes to be in contact with human body. This not only interferes with the driver operation, but also is not feasible for long-term monitoring purpose. The driver assistance system in this paper can remotely detect the biopotential signals with no physical contact with human skin. With delicate sensor and electronic design, ECG, EEG, and eye blinking can be measured. Experiments were conducted on a high fidelity driving simulator to validate the system performance. The system was found to be able to detect the ECG/EEG signals through cloth or hair with no contact with skin. Eye blinking activities can also be detected at a distance of 10 cm. Digital signal processing algorithms were developed to decimate the signal noise and extract the physiological features. The extracted features from the vital signals were further analyzed to assess the potential criterion for alertness and drowsiness determination. PMID:25375690

  20. Digital signal transmission with cascaded heterogeneous chaotic systems

    Science.gov (United States)

    Murali, K.

    2001-01-01

    A new chaos based secure communication scheme is proposed to transmit digital signals by combining the concepts of chaotic-switching and chaotic-modulation approaches. In this scheme two heterogeneous chaotic circuits are used both at the transmitter and receiver modules. First a binary message signal is scrambled by two chaotic attractors produced by a set of chaotic systems (No. 1) of the drive module. The so produced small amplitude scrambled chaotic signal is further directly injected or modulated by different chaotic system (No. 2) within the drive module. Then the chaotic signal generated by this second chaotic system No. 2 is transmitted to the response module through the channel. An appropriate feedback loop is constructed in the response module to achieve synchronization among the variables of the drive and response modules and the binary information signal is recovered by using the synchronization error followed by low-pass filtering and thresholding. Simulation results are reported in which the quality of the recovered signal is higher and the encoding of the information signal is potentially secure. The effect of perturbing factors like channel noise and nonidentity of parameters are also considered.

  1. Exploitation of Ubiquitous Wi-Fi Devices as Building Blocks for Improvised Motion Detection Systems

    Directory of Open Access Journals (Sweden)

    Francesco Soldovieri

    2016-02-01

    Full Text Available This article deals with a feasibility study on the detection of human movements in indoor scenarios based on radio signal strength variations. The sensing principle exploits the fact that the human body interacts with wireless signals, introducing variations of the radiowave fields due to shadowing and multipath phenomena. As a result, human motion can be inferred from fluctuations of radiowave power collected by a receiving terminal. In this paper, we investigate the potentialities of widely available wireless communication devices in order to develop an improvised motion detection system (IMDS. Experimental tests are performed in an indoor environment by using a smartphone as a Wi-Fi access point and a laptop with dedicated software as a receiver. Simple detection strategies tailored for real-time operation are implemented to process the received signal strength measurements. The achieved results confirm the potentialities of the simple system here proposed to reliably detect human motion in operational conditions.

  2. Exploitation of Ubiquitous Wi-Fi Devices as Building Blocks for Improvised Motion Detection Systems.

    Science.gov (United States)

    Soldovieri, Francesco; Gennarelli, Gianluca

    2016-01-01

    This article deals with a feasibility study on the detection of human movements in indoor scenarios based on radio signal strength variations. The sensing principle exploits the fact that the human body interacts with wireless signals, introducing variations of the radiowave fields due to shadowing and multipath phenomena. As a result, human motion can be inferred from fluctuations of radiowave power collected by a receiving terminal. In this paper, we investigate the potentialities of widely available wireless communication devices in order to develop an improvised motion detection system (IMDS). Experimental tests are performed in an indoor environment by using a smartphone as a Wi-Fi access point and a laptop with dedicated software as a receiver. Simple detection strategies tailored for real-time operation are implemented to process the received signal strength measurements. The achieved results confirm the potentialities of the simple system here proposed to reliably detect human motion in operational conditions. PMID:26927126

  3. New block matrix spectral problem and Hamiltonian structure of the discrete integrable coupling system

    International Nuclear Information System (INIS)

    In [W.X. Ma, J. Phys. A: Math. Theor. 40 (2007) 15055], Prof. Ma gave a beautiful result (a discrete variational identity). In this Letter, based on a discrete block matrix spectral problem, a new hierarchy of Lax integrable lattice equations with four potentials is derived. By using of the discrete variational identity, we obtain Hamiltonian structure of the discrete soliton equation hierarchy. Finally, an integrable coupling system of the soliton equation hierarchy and its Hamiltonian structure are obtained through the discrete variational identity

  4. Modelling of composite concrete block pavement systems applying a cohesive zone model

    DEFF Research Database (Denmark)

    Skar, Asmus; Poulsen, Peter Noe

    This paper presents a numerical analysis of the fracture behaviour of the cement bound base material in composite concrete block pavement systems, using a cohesive zone model. The functionality of the proposed model is tested on experimental and numerical investigations of beam bending tests. The...... cohesive model is suitable for simulation of crack propagation in cement bound materials subjected to monotonic loading. The methodology implemented gives a new understanding of the mechanical behaviour of cement bound materials which can be used in further refinements of mechanical models for composite...

  5. A function-blocking CD47 antibody suppresses stem cell and EGF signaling in triple-negative breast cancer

    Science.gov (United States)

    Kaur, Sukhbir; Elkahloun, Abdel G.; Singh, Satya P.; Chen, Qing-Rong; Meerzaman, Daoud M.; Song, Timothy; Manu, Nidhi; Wu, Weiwei; Mannan, Poonam; Garfield, Susan H.; Roberts, David D.

    2016-01-01

    CD47 is a signaling receptor for thrombospondin-1 and the counter-receptor for signal-regulatory protein-α (SIRPα). By inducing inhibitory SIRPα signaling, elevated CD47 expression by some cancers prevents macrophage phagocytosis. The anti-human CD47 antibody B6H12 inhibits tumor growth in several xenograft models, presumably by preventing SIRPα engagement. However, CD47 signaling in nontransformed and some malignant cells regulates self-renewal, suggesting that CD47 antibodies may therapeutically target cancer stem cells (CSCs). Treatment of MDA-MB-231 breast CSCs with B6H12 decreased proliferation and asymmetric cell division. Similar effects were observed in T47D CSCs but not in MCF7 breast carcinoma or MCF10A breast epithelial cells. Gene expression analysis in breast CSCs treated with B6H12 showed decreased expression of epidermal growth factor receptor (EGFR) and the stem cell transcription factor KLF4. EGFR and KLF4 mRNAs are known targets of microRNA-7, and B6H12 treatment correspondingly enhanced microRNA-7 expression in breast CSCs. B6H12 treatment also acutely inhibited EGF-induced EGFR tyrosine phosphorylation. Expression of B6H12-responsive genes correlated with CD47 mRNA expression in human breast cancers, suggesting that the CD47 signaling pathways identified in breast CSCs are functional in vivo. These data reveal a novel SIRPα-independent mechanism by which therapeutic CD47 antibodies could control tumor growth by autonomously forcing differentiation of CSC. PMID:26840086

  6. A Bioassay System Using Bioelectric Signals from Small Fish

    Science.gov (United States)

    Terawaki, Mitsuru; Soh, Zu; Hirano, Akira; Tsuji, Toshio

    Although the quality of tap water is generally examined using chemical assay, this method cannot be used for examination in real time. Against such a background, the technique of fish bioassay has attracted attention as an approach that enables constant monitoring of aquatic contamination. The respiratory rhythms of fish are considered an efficient indicator for the ongoing assessment of water quality, since they are sensitive to chemicals and can be indirectly measured from bioelectric signals generated by breathing. In order to judge aquatic contamination accurately, it is necessary to measure bioelectric signals from fish swimming freely as well as to stably discriminate measured signals, which vary between individuals. However, no bioassay system meeting the above requirements has yet been established. This paper proposes a bioassay system using bioelectric signals generated from small fish in free-swimming conditions. The system records signals using multiple electrodes to cover the extensive measurement range required in a free-swimming environment, and automatically discriminates changes in water quality from signal frequency components. This discrimination is achieved through an ensemble classification method using probability neural networks to solve the problem of differences between individual fish. The paper also reports on the results of related validation experiments, which showed that the proposed system was able to stably discriminate between water conditions before and after bleach exposure.

  7. Application of signal detection theory to assess optoacoustic imaging systems

    Science.gov (United States)

    Lou, Yang; Oraevsky, Alexander; Anastasio, Mark A.

    2016-03-01

    The hybrid nature of optoacoustic tomography (OAT) brings together the advantages of both optical imaging and ultrasound imaging, making it a promising tool for breast cancer imaging. It is advocated in the modern imaging science literature to utilize objective, or task-based, measures of system performance to guide the optimization of hardware design and image reconstruction algorithms. In this work, we investigate this approach to assess the performance of OAT breast imaging systems. In particular, we apply principles from signal detection theory to compute the detectability of a simulated tumor at different depths within a breast, for two different system designs. The signal-to-noise ratio of the test statistic computed by a numerical observer is employed as the task-specific summary measure of system performance. A numerical breast model is employed that contains both slowly varying background and vessel structures as the background model, and superimpose a deterministic signal to emulate a tumor. This study demonstrates how signal detection performance of a numerical observer will vary as a function of signal depth and imaging system characteristics. The described methodology can be employed readily to systematically optimize other OAT imaging systems for tumor detection tasks.

  8. Signalization system with remote notification and control

    OpenAIRE

    Bachynskyy, R

    2013-01-01

    This article presents alarm system, which sends voice messages to appropriate responder via telephone line, when some problems occur on the controlled area. Only one PSoC is used to rich functionality implementation. Наведено систему сигналізації тривожних подій, яка передає голосові повідомлення відповідному отримувачу через провідну телефонну мережу загального призначення, у разі виникнення проблем на контрольованій території. У цій системі використано тільки один програмований мікроконтрол...

  9. Outage performance of cognitive radio systems with Improper Gaussian signaling

    KAUST Repository

    Amin, Osama

    2015-06-14

    Improper Gaussian signaling has proved its ability to improve the achievable rate of the systems that suffer from interference compared with proper Gaussian signaling. In this paper, we first study impact of improper Gaussian signaling on the performance of the cognitive radio system by analyzing the outage probability of both the primary user (PU) and the secondary user (SU). We derive exact expression of the SU outage probability and upper and lower bounds for the PU outage probability. Then, we design the SU signal by adjusting its transmitted power and the circularity coefficient to minimize the SU outage probability while maintaining a certain PU quality-of-service. Finally, we evaluate the proposed bounds and adaptive algorithms by numerical results.

  10. Relationship between blocking temperature and strength of interparticle interaction in magnetic nanoparticle systems

    Science.gov (United States)

    Seehra, M. S.; Pisane, K. L.

    2016-06-01

    In magnetic nanoparticle systems, the variation of the blocking temperature TB with the measuring frequency fm is often used to determine the strength of the interparticle interactions (IPI) through a parameter Φ or the Vogel-Fulcher temperature To. Presence of IPI is inferred if To > 0 and Φ = ∆TB/[ TB ∆ log10fm ] < 0.13 where Δ signifies changes in TB and fm. Here it is shown that these two parameters are related by the Eq. Φ = Φo [ 1 - (To/TB(1)) ] where Φo ≈ 0.11-0.15 is a constant of the system depending on the magnitudes of measuring frequency and the attempt frequency fo of the Néel relaxation. Using data on a variety of nanoparticle systems, experimental verification of this relationship is also presented.

  11. A VME barrel shifter system for event reconstruction for up to 3 Gbps signal trains

    International Nuclear Information System (INIS)

    A VME barrel shifter system for event reconstruction was developed for the SDC experiment. A special semicustom switch IC was also developed for it. This system takes in fragments of a physical event through its inputs, combines and reorganizes the fragments and produces a complete data set of the event from one of its outputs. The complete output data set for successive events will be delivered to waiting computers at its outputs. Up to 3 Gbps signal trains can be fed through the switch unit. This system is VME 6U compatible and the switching can be controlled by a commercially available VME module. Building blocks of this barrel shifter system are switch modules, optical to electrical and electrical to optical converter modules and a dedicated crate. The switch modules are a dual-4 x 4/quad-2 x 2 unit and an 8 x 8 unit, and they can be combined to deal with very large number of I/O channels

  12. Signals and systems for bioengineers a Matlab-based introduction

    CERN Document Server

    Semmlow, John

    2011-01-01

    This book guides the reader through the electrical engineering principles that can be applied to biological systems and are therefore important to biomedical studies. The basic engineering concepts that underlie biomedical systems, medical devices, biocontrol, and biosignal analysis are explained in detail.This textbook is perfect for the one-semester bioengineering course usually offered in conjunction with a laboratory on signals and measurements which presents the fundamentals of systems and signal analysis. The target course occupies a pivotal position in the bioengineering curricu

  13. Input–output robustness in simple bacterial signaling systems

    OpenAIRE

    Shinar, Guy; Milo, Ron; Martínez, María Rodríguez; Alon, Uri

    2007-01-01

    Biological signaling systems produce an output, such as the level of a phosphorylated protein, in response to defined input signals. The output level as a function of the input level is called the system's input–output relation. One may ask whether this input–output relation is sensitive to changes in the concentrations of the system's components, such as proteins and ATP. Because component concentrations often vary from cell to cell, it might be expected that the input–output relation will l...

  14. Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells

    OpenAIRE

    Pan, Jing-Xuan; Ding, Ke; Wang, Cheng-Yan

    2012-01-01

    Niclosamide, an oral antihelminthic drug, has been used to treat tapeworm infection for about 50 years. Niclosamide is also used as a molluscicide for water treatment in schistosomiasis control programs. Recently, several groups have independently discovered that niclosamide is also active against cancer cells, but its precise mechanism of antitumor action is not fully understood. Evidence supports that niclosamide targets multiple signaling pathways (NF-κB, Wnt/β-catenin, Notch, ROS, mTORC1,...

  15. Sorafenib inhibits tumor growth and vascularization of rhabdomyosarcoma cells by blocking IGF-1R-mediated signaling

    OpenAIRE

    Maruwge, Wessen; D’Arcy, Pádraig; Folin, Annika; Brnjic, Slavica; Wejde, Johan; Davis, Anthony; Erlandsson, Fredrik; Bergh, Jonas; Brodin, Bertha

    2008-01-01

    The growth of many soft tissue sarcomas is dependent on aberrant growth factor signaling, which promotes their proliferation and motility. With this in mind, we evaluated the effect of sorafenib, a receptor tyrosine kinase inhibitor, on cell growth and apoptosis in sarcoma cell lines of various histological subtypes. We found that sorafenib effectively inhibited cell proliferation in rhabdomyosarcoma, synovial sarcoma and Ewing’s sarcoma with IC50 values

  16. Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.

    Science.gov (United States)

    Tokarski, John S; Zupa-Fernandez, Adriana; Tredup, Jeffrey A; Pike, Kristen; Chang, ChiehYing; Xie, Dianlin; Cheng, Lihong; Pedicord, Donna; Muckelbauer, Jodi; Johnson, Stephen R; Wu, Sophie; Edavettal, Suzanne C; Hong, Yang; Witmer, Mark R; Elkin, Lisa L; Blat, Yuval; Pitts, William J; Weinstein, David S; Burke, James R

    2015-04-24

    Inhibition of signal transduction downstream of the IL-23 receptor represents an intriguing approach to the treatment of autoimmunity. Using a chemogenomics approach marrying kinome-wide inhibitory profiles of a compound library with the cellular activity against an IL-23-stimulated transcriptional response in T lymphocytes, a class of inhibitors was identified that bind to and stabilize the pseudokinase domain of the Janus kinase tyrosine kinase 2 (Tyk2), resulting in blockade of receptor-mediated activation of the adjacent catalytic domain. These Tyk2 pseudokinase domain stabilizers were also shown to inhibit Tyk2-dependent signaling through the Type I interferon receptor but not Tyk2-independent signaling and transcriptional cellular assays, including stimulation through the receptors for IL-2 (JAK1- and JAK3-dependent) and thrombopoietin (JAK2-dependent), demonstrating the high functional selectivity of this approach. A crystal structure of the pseudokinase domain liganded with a representative example showed the compound bound to a site analogous to the ATP-binding site in catalytic kinases with features consistent with high ligand selectivity. The results support a model where the pseudokinase domain regulates activation of the catalytic domain by forming receptor-regulated inhibitory interactions. Tyk2 pseudokinase stabilizers, therefore, represent a novel approach to the design of potent and selective agents for the treatment of autoimmunity. PMID:25762719

  17. Let-7c blocks estrogen-activated Wnt signaling in induction of self-renewal of breast cancer stem cells.

    Science.gov (United States)

    Sun, X; Xu, C; Tang, S-C; Wang, J; Wang, H; Wang, P; Du, N; Qin, S; Li, G; Xu, S; Tao, Z; Liu, Dapeng; Ren, H

    2016-04-01

    Let-7 miRNAs are involved in carcinogenesis and tumor progression through their roles in maintaining differentiation and normal development. However, there is little research focusing on the effects of let-7 on Wnt-activated self-renewal of breast cancer stem cells. By analyzing the expression levels of let-7 family members in clinical tissues, we found that higher expression levels of let-7b and let-7c were correlated with better clinical prognosis of patients with estrogen receptor (ER)α-positive breast tumor. Further, we found that only let-7c was inversely correlated with ERα expression, and there is corelationship between let-7c and Wnt signaling in clinical tissues. Aldehyde dehydrogenase (ALDH)1 sorting and mammosphere formation assays showed that let-7c inhibited the self-renewal of stem cells in ERα-positive breast cancer. Let-7c decreased ERα expression through directly binding to the 3'UTR (untranslated region), and let-7c inhibited the estrogen-induced activation of Wnt signaling. Depletion of ERα abolished let-7c functions in stem cell signatures, which further confirmed that let-7c inhibited estrogen-induced Wnt activity through decreasing ERα expression. Taken together, our findings identified a biochemical and functional link between let-7c with ERα/Wnt signaling in breast cancer stem cells. PMID:26987290

  18. Digital Signal Processor System for AC Power Drivers

    Directory of Open Access Journals (Sweden)

    Ovidiu Neamtu

    2009-10-01

    Full Text Available DSP (Digital Signal Processor is the bestsolution for motor control systems to make possible thedevelopment of advanced motor drive systems. The motorcontrol processor calculates the required motor windingvoltage magnitude and frequency to operate the motor atthe desired speed. A PWM (Pulse Width Modulationcircuit controls the on and off duty cycle of the powerinverter switches to vary the magnitude of the motorvoltages.

  19. Approximate formulae for the thermalization of two blocks in an insulated system

    International Nuclear Information System (INIS)

    When two blocks are put in thermal contact, heat flows from the hotter block to the cooler until thermal equilibrium is reached. On thinking about the evolution of this system towards equilibrium, some interesting questions arise. Could we establish a good criterion for identifying the end of the heat transfer? If so, typically how long does it take for thermal equilibrium to be reached? What is the typical outline of the temperature distribution during the heat transfer? Although heat conduction is an important topic in science and engineering courses, only the last question is addressed in textbooks for undergraduates and it is answered based upon the Fourier series solution of the heat equation. In this work, I begin by showing that the first term of the exact Fourier series solution is itself an accurate approximation for the temperature profile for t>0.7τd, where τd is the diffusive time constant for heat conduction in this system. I then introduce a ‘practical’ thermalization time which depends upon the difference of initial temperatures and the instrumental error of the thermometer, which satisfactorily answers the above questions. (paper)

  20. Blind and semi-blind ML detection for space-time block-coded OFDM wireless systems

    KAUST Repository

    Zaib, Alam

    2014-01-01

    This paper investigates the joint maximum likelihood (ML) data detection and channel estimation problem for Alamouti space-time block-coded (STBC) orthogonal frequency-division multiplexing (OFDM) wireless systems. The joint ML estimation and data detection is generally considered a hard combinatorial optimization problem. We propose an efficient low-complexity algorithm based on branch-estimate-bound strategy that renders exact joint ML solution. However, the computational complexity of blind algorithm becomes critical at low signal-to-noise ratio (SNR) as the number of OFDM carriers and constellation size are increased especially in multiple-antenna systems. To overcome this problem, a semi-blind algorithm based on a new framework for reducing the complexity is proposed by relying on subcarrier reordering and decoding the carriers with different levels of confidence using a suitable reliability criterion. In addition, it is shown that by utilizing the inherent structure of Alamouti coding, the estimation performance improvement or the complexity reduction can be achieved. The proposed algorithms can reliably track the wireless Rayleigh fading channel without requiring any channel statistics. Simulation results presented against the perfect coherent detection demonstrate the effectiveness of blind and semi-blind algorithms over frequency-selective channels with different fading characteristics.

  1. A New Indoor Positioning System Architecture Using GPS Signals

    Directory of Open Access Journals (Sweden)

    Rui Xu

    2015-04-01

    Full Text Available The pseudolite system is a good alternative for indoor positioning systems due to its large coverage area and accurate positioning solution. However, for common Global Positioning System (GPS receivers, the pseudolite system requires some modifications of the user terminals. To solve the problem, this paper proposes a new pseudolite-based indoor positioning system architecture. The main idea is to receive real-world GPS signals, repeat each satellite signal and transmit those using indoor transmitting antennas. The transmitted GPS-like signal can be processed (signal acquisition and tracking, navigation data decoding by the general receiver and thus no hardware-level modification on the receiver is required. In addition, all Tx can be synchronized with each other since one single clock is used in Rx/Tx. The proposed system is simulated using a software GPS receiver. The simulation results show the indoor positioning system is able to provide high accurate horizontal positioning in both static and dynamic situations.

  2. The Ballistocardiogram Signal Monitoring System Based on the GSM Network

    Institute of Scientific and Technical Information of China (English)

    WANG Chun-wu; WANG Xu; LONG Zhe; ZHANG Ke-xin; YANG Dan

    2015-01-01

    Ballistocardiogram signal monitoring system based on GSM network was put forward in this paper. The system included a BCG signal acquisition module, a data processing module, a display module and a GSM module. The STM32F103VB microprocessor was used as the controlling core of the signal acquisition module. BCG signal acquisition, amplification, filtering and A/D conversion were completed by the resistance strain sensor and high precision A/D conversion chip of TM7708; VB6.0 software was used to realize the BCG signal analysis and processing;the SD card and LCD completed data storage and waveform display; the BCG data remote transmission and alarm function were realized through the GSM module. The system cannot only real-time monitor the changes of heart rate of patients by non-contact means, and can process data automatically, timely detection of arrhythmia and automatic alarm. The system is particularly suitable for heart disease patients receiving long-term home care;therefore, it has a broad application prospect.

  3. Parallel Signal Processing and System Simulation using aCe

    Science.gov (United States)

    Dorband, John E.; Aburdene, Maurice F.

    2003-01-01

    Recently, networked and cluster computation have become very popular for both signal processing and system simulation. A new language is ideally suited for parallel signal processing applications and system simulation since it allows the programmer to explicitly express the computations that can be performed concurrently. In addition, the new C based parallel language (ace C) for architecture-adaptive programming allows programmers to implement algorithms and system simulation applications on parallel architectures by providing them with the assurance that future parallel architectures will be able to run their applications with a minimum of modification. In this paper, we will focus on some fundamental features of ace C and present a signal processing application (FFT).

  4. Application of Block Copolymer in Three-Liquid-Phase Extraction System

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    A novel three-liquid-phase extraction system (TES) composed of butyl acetate, block copolymer polyethylene oxide-polypropylene oxide-polyethylene oxide and ammonium sulphate aqueous solution [(NH4)2SO4] as top, middle, and bottom phase, respectively, has been developed. The copolymer recycling and partitioning behavior of penicillin V has been studied in this system. Results show that the copolymer could be purified and recycled and penicillin V of the filtrated ferment broth could be partitioned unevenly among the phases and purified in the top phase of this TES. About 90 wt.% of penicillin V could be distributed into the top phase around pH 2.5 and only less than 0.1 wt.% left in the bottom phase.

  5. Block structured adaptive mesh and time refinement for hybrid, hyperbolic + N-body systems

    Science.gov (United States)

    Miniati, Francesco; Colella, Phillip

    2007-11-01

    We present a new numerical algorithm for the solution of coupled collisional and collisionless systems, based on the block structured adaptive mesh and time refinement strategy (AMR). We describe the issues associated with the discretization of the system equations and the synchronization of the numerical solution on the hierarchy of grid levels. We implement a code based on a higher order, conservative and directionally unsplit Godunov’s method for hydrodynamics; a symmetric, time centered modified symplectic scheme for collisionless component; and a multilevel, multigrid relaxation algorithm for the elliptic equation coupling the two components. Numerical results that illustrate the accuracy of the code and the relative merit of various implemented schemes are also presented.

  6. Performance of Turbo Interference Cancellation Receivers in Space-Time Block Coded DS-CDMA Systems

    Directory of Open Access Journals (Sweden)

    Emmanuel Oluremi Bejide

    2008-07-01

    Full Text Available We investigate the performance of turbo interference cancellation receivers in the space time block coded (STBC direct-sequence code division multiple access (DS-CDMA system. Depending on the concatenation scheme used, we divide these receivers into the partitioned approach (PA and the iterative approach (IA receivers. The performance of both the PA and IA receivers is evaluated in Rayleigh fading channels for the uplink scenario. Numerical results show that the MMSE front-end turbo space-time iterative approach receiver (IA effectively combats the mixture of MAI and intersymbol interference (ISI. To further investigate the possible achievable data rates in the turbo interference cancellation receivers, we introduce the puncturing of the turbo code through the use of rate compatible punctured turbo codes (RCPTCs. Simulation results suggest that combining interference cancellation, turbo decoding, STBC, and RCPTC can significantly improve the achievable data rates for a synchronous DS-CDMA system for the uplink in Rayleigh flat fading channels.

  7. A four-channel microelectronic system for neural signal regeneration

    Energy Technology Data Exchange (ETDEWEB)

    Xie Shushan; Wang Zhigong; Li Wenyuan [Institute of RF- and OE-ICs, Southeast University, Nanjing 210096 (China); Lue Xiaoying; Pan Haixian, E-mail: zgwang@seu.edu.c [State Key Laboratory of Bio-Electronics, Southeast University, Nanjing 210096 (China)

    2009-12-15

    This paper presents a microelectronic system which is capable of making a signal record and functional electric stimulation of an injured spinal cord. As a requirement of implantable engineering for the regeneration microelectronic system, the system is of low noise, low power, small size and high performance. A front-end circuit and two high performance OPAs (operational amplifiers) have been designed for the system with different functions, and the two OPAs are a low-noise low-power two-stage OPA and a constant-g{sub m} RTR input and output OPA. The system has been realized in CSMC 0.5-{mu}m CMOS technology. The test results show that the system satisfies the demands of neuron signal regeneration. (semiconductor integrated circuits)

  8. A four-channel microelectronic system for neural signal regeneration

    Institute of Scientific and Technical Information of China (English)

    Xie Shushan; Wang Zhigong; Lü Xiaoying; Li Wenyuan; Pan Haixian

    2009-01-01

    This paper presents a microelectronic system which is capable of making a signal record and functional electric stimulation of an injured spinal cord. As a requirement of implantable engineering for the regeneration microelectronic system, the system is of low noise, low power, small size and high performance. A front-end circuit and two high performance OPAs (operational amplifiers) have been designed for the system with different functions,and the two OPAs are a low-noise low-power two-stage OPA and a constant-g_m RTR input and output OPA. The system has been realized in CSMC 0.5-μm CMOS technology. The test results show that the system satisfies the demands of neuron signal regeneration.

  9. A block iterative LU solver for weakly coupled linear systems. [in fluid dynamics equations

    Science.gov (United States)

    Cooke, C. H.

    1977-01-01

    A hybrid technique, called the block iterative LU solver, is proposed for solving the linear equations resulting from a finite element numerical analysis of certain fluid dynamics problems where the equations are weakly coupled between distinct sets of variables. Either the block Jacobi iterative method or the block Gauss-Seidel iterative solver is combined with LU decomposition.

  10. A Multiagent System for Integrated Detection of Pharmacovigilance Signals.

    Science.gov (United States)

    Koutkias, Vassilis; Jaulent, Marie-Christine

    2016-02-01

    Pharmacovigilance is the scientific discipline that copes with the continuous assessment of the safety profile of marketed drugs. This assessment relies on diverse data sources, which are routinely analysed to identify the so-called "signals", i.e. potential associations between drugs and adverse effects, that are unknown or incompletely documented. Various computational methods have been proposed to support domain experts in signal detection. However, recent comparative studies illustrated that current methods exhibit high false-positive rates, significantly variable performance across different datasets used for analysis and events of interest, but also complementarity in their outcomes. In this regard, in order to reinforce accurate and timely signal detection, we elaborated through an agent-based approach towards systematic, joint exploitation of multiple heterogeneous signal detection methods, data sources and other drug-related resources under a common, integrated framework. The approach relies on a multiagent system operating based on a collaborative agent interaction protocol, aiming to implement a comprehensive workflow that comprises of method selection and execution, as well as outcomes' aggregation, filtering, ranking and annotation. This paper presents the design of the proposed multiagent system, discusses implementation issues and demonstrates the applicability of the proposed solution in an example signal detection scenario. This work constitutes a step towards large-scale, integrated and knowledge-intensive computational signal detection. PMID:26590975

  11. Berberine Protects Human Umbilical Vein Endothelial Cells against LPS-Induced Apoptosis by Blocking JNK-Mediated Signaling

    Science.gov (United States)

    Guo, Junping; Wang, Lijun; Wang, Linyao; Qian, Senmi; Fang, Jie

    2016-01-01

    Endothelial dysfunction is a critical factor during the initiation of atherosclerosis. Berberine has a beneficial effect on endothelial function; however, the underlying mechanisms remain unclear. In this study, we investigated the effects of berberine on lipopolysaccharide- (LPS-) induced apoptosis in human umbilical vein endothelial cells (HUVECs) and the molecular mechanisms mediating the effect. The effects of berberine on LPS-induced cell apoptosis and viability were measured with 5-ethynyl-2′-deoxyuridine staining, flow cytometry, and Cell Counting Kit-8 assays. The expression and/or activation of proapoptotic and antiapoptotic proteins or signaling pathways, including caspase-3, poly(ADP-ribose) polymerase, myeloid cell leukemia-1 (MCL-1), p38 mitogen-activated protein kinase, C-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinase, were determined with western blotting. The malondialdehyde levels, superoxide dismutase (SOD) activity, and production of proinflammatory cytokines were measured with enzyme-linked immunosorbent assays. The results demonstrated that berberine pretreatment protected HUVECs from LPS-induced apoptosis, attenuated LPS-induced injury, inhibited LPS-induced JNK phosphorylation, increased MCL-1 expression and SOD activity, and decreased proinflammatory cytokine production. The effects of berberine on LPS-treated HUVECs were prevented by SP600125, a JNK-specific inhibitor. Thus, berberine might be a potential candidate in the treatment of endothelial cell injury-related vascular diseases. PMID:27478481

  12. System spectral analysis of the fractal ultra-wideband signals

    International Nuclear Information System (INIS)

    The theoretical basis and practical peculiarities of the system spectral analysis are briefly considered. The necessity and the expediency of simultaneously application of different linear and non-linear integral transforms during the system spectral analysis performance are explained. The system spectral analysis usage for investigations of the time-frequency structure of the fractal ultra-wideband signals is shown to be effective and useful.

  13. An Optical Tomography System Using a Digital Signal Processor

    OpenAIRE

    Mohd Hafiz Fazalul Rahiman; Chiam Kok Thiam; Ruzairi Abdul Rahim

    2008-01-01

    The use of a personal computer together with a Data Acquisition System (DAQ) as the processing tool in optical tomography systems has been the norm ever since the beginning of process tomography. However, advancements in silicon fabrication technology allow nowadays the fabrication of powerful Digital Signal Processors (DSP) at a reasonable cost. This allows this technology to be used in an optical tomography system since data acquisition and processing can be performed within the DSP. Thus, ...

  14. Wearable System for Acquisition and Monitoring of Biological Signals

    Science.gov (United States)

    Piccinini, D. J.; Andino, N. B.; Ponce, S. D.; Roberti, MA; López, y. N.

    2016-04-01

    This paper presents a modular, wearable system for acquisition and wireless transmission of biological signals. Configurable slaves for different signals (such as ECG, EMG, inertial sensors, and temperature) based in the ADS1294 Medical Analog Front End are connected to a Master, based in the CC3200 microcontroller, both from Texas Instruments. The slaves are configurable according to the specific application, providing versatility to the wearable system. The battery consumption is reduced, through a couple of Li-ion batteries and the circuit has also a battery charger. A custom made box was designed and fabricated in a 3D printer, preserving the requirements of low cost, low weight and safety recommendations.

  15. [A telemetery system for neural signal acquiring and processing].

    Science.gov (United States)

    Wang, Min; Song, Yongji; Suen, Jiantao; Zhao, Yiliang; Jia, Aibin; Zhu, Jianping

    2011-02-01

    Recording and extracting characteristic brain signals in freely moving animals is the basic and significant requirement in the study of brain-computer interface (BCI). To record animal's behaving and extract characteristic brain signals simultaneously could help understand the complex behavior of neural ensembles. Here, a system was established to record and analyse extracellular discharge in freely moving rats for the study of BCI. It comprised microelectrode and micro-driver assembly, analog front end (AFE), programmer system on chip (PSoC), wireless communication and the LabVIEW used as the platform for the graphic user interface. PMID:21485182

  16. Optimal signal detection in entanglement-assisted quantum communication systems

    International Nuclear Information System (INIS)

    Minimization of error probability is considered in entanglement-assisted quantum communication systems. It is shown that although quantum state signals being sent are not symmetric at a sender side, the square root measurement becomes optimum when they are made symmetric at the receiver side. For communication systems of coherent signals, where a two-mode squeezed-vacuum state is used as an entanglement resource, the quantum entanglement greatly reduces the average probability of error. The relation to the quantum dense coding of continuous variables is also discussed

  17. Complete Congenital Heart Block in a Newborn Associated with Maternal Systemic Lupus Erythematosus: A Case Report

    Directory of Open Access Journals (Sweden)

    Mahmoud A. Kiblawi

    2013-12-01

    Full Text Available Background: Complete Congenital Heart Block (CCHB is a rare disease of the newborn that carries significant morbidity and mortality. CCHB can be diagnosed early or late in life. In newborns, it is usually associated with maternal autoantibodies or a congenital cardiac structural abnormality. The most common presentation of CCHB is bradycardia that can be diagnosed by an electrocardiogram. Results: This is a case report of a male infant born to a mother with an autoimmune disease, Systemic Lupus Erythematosus (SLE, who was found to have third degree heart block at birth. Conclusion: Early diagnosis and prompt management of the case is important for a better prognosis and prevention of associated complications. Neonates with CCHB should be managed at a tertiary care center and the only definite treatment is insertion of a pacemaker. Moreover, prenatal diagnosis and specific obstetric counseling of pregnant women with SLE along with careful monitoring with serial ultrasonography and echocardiography are of paramount importance in prevention of the disease in subsequent offspring.

  18. Phosphoproteomics-based systems analysis of signal transduction networks

    Directory of Open Access Journals (Sweden)

    Hiroko eKozuka-Hata

    2012-01-01

    Full Text Available Signal transduction systems coordinate complex cellular information to regulate biological events such as cell proliferation and differentiation. Although the accumulating evidence on widespread association of signaling molecules has revealed essential contribution of phosphorylation-dependent interaction networks to cellular regulation, their dynamic behavior is mostly yet to be analyzed. Recent technological advances regarding mass spectrometry-based quantitative proteomics have enabled us to describe the comprehensive status of phosphorylated molecules in a time-resolved manner. Computational analyses based on the phosphoproteome dynamics accelerate generation of novel methodologies for mathematical analysis of cellular signaling. Phosphoproteomics-based numerical modeling can be used to evaluate regulatory network elements from a statistical point of view. Integration with transcriptome dynamics also uncovers regulatory hubs at the transcriptional level. These omics-based computational methodologies, which have firstly been applied to representative signaling systems such as the epidermal growth factor receptor pathway, have now opened up a gate for systems analysis of signaling networks involved in immune response and cancer.

  19. Signal Adaptive System for Space/Spatial-Frequency Analysis

    Directory of Open Access Journals (Sweden)

    Veselin N. Ivanović

    2009-01-01

    Full Text Available This paper outlines the development of a multiple-clock-cycle implementation (MCI of a signal adaptive two-dimensional (2D system for space/spatial-frequency (S/SF signal analysis. The design is based on a method for improved S/SF representation of the analyzed 2D signals, also proposed here. The proposed MCI design optimizes critical design performances related to hardware complexity, making it a suitable system for real time implementation on an integrated chip. Additionally, the design allows the implemented system to take a variable number of clock cycles (CLKs (the only necessary ones regarding desirable—2D Wigner distribution-presentation of autoterms in different frequency-frequency points during the execution. This ability represents a major advantage of the proposed design which helps to optimize the time required for execution and produce an improved, cross-terms-free S/SF signal representation. The design has been verified by a field-programmable gate array (FPGA circuit design, capable of performing S/SF analysis of 2D signals in real time.

  20. Digital Signal Processing for In-Vehicle Systems and Safety

    CERN Document Server

    Boyraz, Pinar; Takeda, Kazuya; Abut, Hüseyin

    2012-01-01

    Compiled from papers of the 4th Biennial Workshop on DSP (Digital Signal Processing) for In-Vehicle Systems and Safety this edited collection features world-class experts from diverse fields focusing on integrating smart in-vehicle systems with human factors to enhance safety in automobiles. Digital Signal Processing for In-Vehicle Systems and Safety presents new approaches on how to reduce driver inattention and prevent road accidents. The material addresses DSP technologies in adaptive automobiles, in-vehicle dialogue systems, human machine interfaces, video and audio processing, and in-vehicle speech systems. The volume also features: Recent advances in Smart-Car technology – vehicles that take into account and conform to the driver Driver-vehicle interfaces that take into account the driving task and cognitive load of the driver Best practices for In-Vehicle Corpus Development and distribution Information on multi-sensor analysis and fusion techniques for robust driver monitoring and driver recognition ...

  1. Autonomous data acquisition system for Paks NPP process noise signals

    International Nuclear Information System (INIS)

    A prototype of a new concept noise diagnostics data acquisition system has been developed recently to renew the aged present system. This new system is capable of collecting the whole available noise signal set simultaneously. Signal plugging and data acquisition are performed by autonomous systems (installed at each reactor unit) that are controlled through the standard plant network from a central computer installed at a suitable location. Experts can use this central unit to process and archive data series downloaded from the reactor units. This central unit also provides selected noise diagnostics information for other departments. The paper describes the hardware and software architecture of the new system in detail, emphasising the potential benefits of the new approach. (author)

  2. Global positioning system (GPS) supported block adjustment with self-calibration parameters

    Science.gov (United States)

    Blankenberg, Leif E.

    1994-08-01

    Systematic errors in the image coordinates is often a problem when working with high accuracy bundle block adjustment. These errors can be modeled by introducing self calibration parameters in the adjustment. In a traditional block adjustment, a dense network of ground control points are required to ensure a reliable estimate of these parameters. In the case of GPS-supported block adjustment, there is usually very little ground control available, but as shown in this paper, it is still possible to estimate the self calibration parameters. This is because of the stabilizing effect the GPS-determined perspective center coordinates have on the block. In this paper, both simulated data and real block data are used to evaluate the accuracy properties of GPS-supported blocks with additional self calibration parameters. Two different sets of additional parameters are evaluated. In the GPS-supported test blocks, the introduction of self calibration parameters improves the empirical tie point accuracy by 30 - 40%.

  3. Advances in signal processing and intelligent recognition systems

    CERN Document Server

    Gelbukh, Alexander; Mukhopadhyay, Jayanta

    2014-01-01

    This Edited Volume contains a selection of refereed and revised papers originally presented at the International Symposium on Signal Processing and Intelligent Recognition Systems (SIRS-2014), March 13-15, 2014, Trivandrum, India. The program committee received 134 submissions from 11 countries. Each paper was peer reviewed by at least three or more independent referees of the program committee and the 52 papers were finally selected. The papers offer stimulating insights into Pattern Recognition, Machine Learning and Knowledge-Based Systems; Signal and Speech Processing; Image and Video Processing; Mobile Computing and Applications and Computer Vision. The book is directed to the researchers and scientists engaged in various field of signal processing and related areas.  

  4. Digital Signal Processing for Optical Coherent Communication Systems

    DEFF Research Database (Denmark)

    Zhang, Xu

    In this thesis, digital signal processing (DSP) algorithms are studied to compensate for physical layer impairments in optical fiber coherent communication systems. The physical layer impairments investigated in this thesis include optical fiber chromatic dispersion, polarization demultiplexing...... less hardware requirements than a conventional serial chromatic dispersion compensation algorithm. In conclusion, the digital signal processing algorithms presented in this thesis have shown to improve the performance of digital assisted coherent receivers for the next generation of optical fiber...... spectrum narrowing tolerance 112-Gb/s DP-QPSK optical coherent systems using digital adaptive equalizer. The demonstrated results show that off-line DSP algorithms are able to reduce the bit error rate (BER) penalty induced by signal spectrum narrowing. Third, we also investigate bi...

  5. Power optimization in wearable biomedical systems: a signal processing perspective

    Science.gov (United States)

    Ghasemzadeh, Hassan

    2012-10-01

    Wearable monitoring systems have caught considerable attention recently due to their potential in many domains including smart health and well-being. These new biomedical monitoring systems aim to provide continuous patient monitoring and proactive care options. Realization of this vision requires research that addresses a number of challenges, in particular, regarding limited resources that the wearable sensor networks offer. This paper presents an overview of different strategies for prolonging system lifetimes through power optimization in such systems. Particular emphasis is given to enhancing processing and communication architectures with respect to the signal processing requirements of the system.

  6. Light relations and performance of signal grass in silvopastoral system

    OpenAIRE

    Cynara Oliveira Diniz Rodrigues; Saulo Alberto do Carmo Araújo; Maria Celuta Machado Viana; Norberto Silva Rocha; Thiago Gomes dos Santos Braz; Severino Delmar Junqueira Villela

    2014-01-01

    The aim was to evaluate the influence of different spatial arrangements of trees [(3×2)×20 m, (2×2)×9 m and 2×9 m] and sampling sites (center of row spacing and side of tree rows) with regard to the amount and quality of light in the understory of silvopastoral systems and their effects on the production and chemical composition of pasture. The experimental design was a randomized block in a split plot, with three replications. The sampling site affected absolute irradiance, photosynthetic ac...

  7. An efficient user scheduling scheme for downlink Multiuser MIMO-OFDM systems with Block Diagonalization

    Directory of Open Access Journals (Sweden)

    Mounir Esslaoui

    2013-06-01

    Full Text Available The combination of multiuser multiple-input multiple-output (MU-MIMO technology with orthogonal frequency division multiplexing (OFDM is an attractive solution for next generation of wireless local area networks (WLANs, currently standardized within IEEE 802.11ac, and the fourth-generation (4G mobile cellular wireless systems to achieve a very high system throughput while satisfying quality of service (QoS constraints. In particular, Block Diagonalization (BD scheme is a low-complexity precoding technique for MU-MIMO downlink channels, which completely pre-cancels the multiuser interference. The major issue of the BD scheme is that the number of users that can be simultaneously supported is limited by the ratio of the number of base station transmit antennas to the number of user receive antennas. When the number of users is large, a subset of users must be selected, and selection algorithms should be designed to maximize the total system throughput. In this paper, the BD technique is extended to MU-MIMO-OFDM systems and a low complexity user scheduling algorithm is proposed to find the optimal subset of users that should transmit simultaneously, in light of the instantaneous channel state information (CSI, such that the total system sum-rate capacity is maximized. Simulation results show that the proposed scheduling algorithm achieves a good trade-off between sum-rate capacity performance and computational complexity.

  8. Space-Frequency Block Code with Matched Rotation for MIMO-OFDM System with Limited Feedback

    Science.gov (United States)

    Zhang, Min; Abhayapala, Thushara D.; Jayalath, Dhammika; Smith, David; Athaudage, Chandra

    2009-12-01

    This paper presents a novel matched rotation precoding (MRP) scheme to design a rate one space-frequency block code (SFBC) and a multirate SFBC for MIMO-OFDM systems with limited feedback. The proposed rate one MRP and multirate MRP can always achieve full transmit diversity and optimal system performance for arbitrary number of antennas, subcarrier intervals, and subcarrier groupings, with limited channel knowledge required by the transmit antennas. The optimization process of the rate one MRP is simple and easily visualized so that the optimal rotation angle can be derived explicitly, or even intuitively for some cases. The multirate MRP has a complex optimization process, but it has a better spectral efficiency and provides a relatively smooth balance between system performance and transmission rate. Simulations show that the proposed SFBC with MRP can overcome the diversity loss for specific propagation scenarios, always improve the system performance, and demonstrate flexible performance with large performance gain. Therefore the proposed SFBCs with MRP demonstrate flexibility and feasibility so that it is more suitable for a practical MIMO-OFDM system with dynamic parameters.

  9. Space-Frequency Block Code with Matched Rotation for MIMO-OFDM System with Limited Feedback

    Directory of Open Access Journals (Sweden)

    Thushara D. Abhayapala

    2009-01-01

    Full Text Available This paper presents a novel matched rotation precoding (MRP scheme to design a rate one space-frequency block code (SFBC and a multirate SFBC for MIMO-OFDM systems with limited feedback. The proposed rate one MRP and multirate MRP can always achieve full transmit diversity and optimal system performance for arbitrary number of antennas, subcarrier intervals, and subcarrier groupings, with limited channel knowledge required by the transmit antennas. The optimization process of the rate one MRP is simple and easily visualized so that the optimal rotation angle can be derived explicitly, or even intuitively for some cases. The multirate MRP has a complex optimization process, but it has a better spectral efficiency and provides a relatively smooth balance between system performance and transmission rate. Simulations show that the proposed SFBC with MRP can overcome the diversity loss for specific propagation scenarios, always improve the system performance, and demonstrate flexible performance with large performance gain. Therefore the proposed SFBCs with MRP demonstrate flexibility and feasibility so that it is more suitable for a practical MIMO-OFDM system with dynamic parameters.

  10. Multiple solutions to dense systems in radar scattering using a preconditioned block GMRES solver

    Energy Technology Data Exchange (ETDEWEB)

    Boyse, W.E. [Advanced Software Resources, Inc., Santa Clara, CA (United States)

    1996-12-31

    Multiple right-hand sides occur in radar scattering calculations in the computation of the simulated radar return from a body at a large number of angles. Each desired angle requires a right-hand side vector to be computed and the solution generated. These right-hand sides are naturally smooth functions of the angle parameters and this property is utilized in a novel way to compute solutions an order of magnitude faster than LINPACK The modeling technique addressed is the Method of Moments (MOM), i.e. a boundary element method for time harmonic Maxwell`s equations. Discretization by this method produces general complex dense systems of rank 100`s to 100,000`s. The usual way to produce the required multiple solutions is via LU factorization and solution routines such as found in LINPACK. Our method uses the block GMRES iterative method to directly iterate a subset of the desired solutions to convergence.

  11. Synthetic modular systems--reverse engineering of signal transduction

    DEFF Research Database (Denmark)

    Pawson, Tony; Linding, Rune

    2005-01-01

    to a deeper and more abstract understanding of signal transduction systems. Designing and successfully introducing synthetic proteins into cellular pathways would provide us with a powerful research tool with many applications, such as development of biosensors, protein drugs and rewiring of...

  12. Cancer systems biology: signal processing for cancer research

    Institute of Scientific and Technical Information of China (English)

    Olli Yli-Harja; Antti Ylip(a)(a); Matti Nykter; Wei Zhang

    2011-01-01

    In this editorial we introduce the research paradigms of signal processing in the era of systems biology. Signal processing is a field of science traditionally focused on modeling electronic and communications systems, but recently it has turned to biological applications with astounding results. The essence of signal processing is to describe the natural world by mathematical models and then, based on these models, develop efficient computational tools for solving engineering problems. Here, we underline, with examples, the endless possibilities which arise when the battle-hardened tools of engineering are applied to solve the problems that have tormented cancer researchers. Based on this approach, a new field has emerged, called cancer systems biology. Despite its short history, cancer systems biology has already produced several success stories tackling previously impracticable problems. Perhaps most importantly, it has been accepted as an integral part of the major endeavors of cancer research, such as analyzing the genomic and epigenomic data produced by The Cancer Genome Atlas (TCGA) project. Finally, we show that signal processing and cancer research, two fields that are seemingly distant from each other, have merged into a field that is indeed more than the sum of its parts.

  13. Dose-response aligned circuits in signaling systems.

    Directory of Open Access Journals (Sweden)

    Long Yan

    Full Text Available Cells use biological signal transduction pathways to respond to environmental stimuli and the behavior of many cell types depends on precise sensing and transmission of external information. A notable property of signal transduction that was characterized in the Saccharomyces cerevisiae yeast cell and many mammalian cells is the alignment of dose-response curves. It was found that the dose response of the receptor matches closely the dose responses of the downstream. This dose-response alignment (DoRA renders equal sensitivities and concordant responses in different parts of signaling system and guarantees a faithful information transmission. The experimental observations raise interesting questions about the nature of the information transmission through DoRA signaling networks and design principles of signaling systems with this function. Here, we performed an exhaustive computational analysis on network architectures that underlie the DoRA function in simple regulatory networks composed of two and three enzymes. The minimal circuits capable of DoRA were examined with Michaelis-Menten kinetics. Several motifs that are essential for the dynamical function of DoRA were identified. Systematic analysis of the topology space of robust DoRA circuits revealed that, rather than fine-tuning the network's parameters, the function is primarily realized by enzymatic regulations on the controlled node that are constrained in limiting regions of saturation or linearity.

  14. Systemic Nutrient and Stress Signaling via Myokines and Myometabolites.

    Science.gov (United States)

    Rai, Mamta; Demontis, Fabio

    2016-01-01

    Homeostatic systems mount adaptive responses to meet the energy demands of the cell and to compensate for dysfunction in cellular compartments. Such surveillance systems are also active at the organismal level: Nutrient and stress sensing in one tissue can lead to changes in other tissues. Here, we review the emerging understanding of the role of skeletal muscle in regulating physiological homeostasis and disease progression in other tissues. Muscle-specific genetic interventions can induce systemic effects indirectly, via changes in the mass and metabolic demand of muscle, and directly, via the release of muscle-derived cytokines (myokines) and metabolites (myometabolites) in response to nutrients and stress. In turn, myokines and myometabolites signal to various target tissues in an autocrine, paracrine, and endocrine manner, thereby determining organismal resilience to aging, disease, and environmental challenges. We propose that tailoring muscle systemic signaling by modulating myokine and myometabolite levels may combat many degenerative diseases and delay aging. PMID:26527185

  15. Increased noise signal processing in incoherent radar systems

    Directory of Open Access Journals (Sweden)

    I. I. Chesanovskyi

    2013-09-01

    Full Text Available Introduction. The work is devoted to the method of increasing coherence and noise immunity pulse radar systems with incoherent sources probing signals. Problem. Incongruities between a resolution and a range of pulsed radar systems can not be resolved within the classical approaches of building incoherent radar systems, requiring new approaches in their construction. The main part. The paper presents a method of two-stage processing incoherent pulsed radar signals, allowing to compensate and use the information available to them and the angular amplitude of spurious modulation. Conclusions. Simulation results and research functions of these expressions of uncertainty indicate that use volatility as an additional transmitter modulation allows to significantly improve the resolution and robustness of the radar system.

  16. Master Clock and Time-Signal-Distribution System

    Science.gov (United States)

    Tjoelker, Robert; Calhoun, Malcolm; Kuhnle, Paul; Sydnor, Richard; Lauf, John

    2007-01-01

    A timing system comprising an electronic master clock and a subsystem for distributing time signals from the master clock to end users is undergoing development to satisfy anticipated timing requirements of NASA s Deep Space Network (DSN) for the next 20 to 30 years. This system has a modular, flexible, expandable architecture that is easier to operate and maintain than the present frequency and timing subsystem (FTS).

  17. Ultrahigh-speed rotating nanoelectromechanical system devices assembled from nanoscale building blocks

    Science.gov (United States)

    Kim, Kwanoh; Xu, Xiaobin; Guo, Jianhe; Fan, D. L.

    2014-04-01

    The development of rotary nanomotors is crucial for advancing nanoelectromechanical system technology. In this work, we report design, assembly and rotation of ordered arrays of nanomotors. The nanomotors are bottom-up assembled from nanoscale building blocks with nanowires as rotors, patterned nanomagnets as bearings and quadrupole microelectrodes as stators. Arrays of nanomotors rotate with controlled angle, speed (over 18,000 r.p.m.), and chirality by electric fields. Using analytical modelling, we reveal the fundamental nanoscale electrical, mechanical and magnetic interactions in the nanomotor system, which excellently agrees with experimental results and provides critical understanding for designing metallic nanoelectromechanical systems. The nanomotors can be continuously rotated for 15 h over 240,000 cycles. They are applied for controlled biochemical release and demonstrate releasing rate of biochemicals on nanoparticles that can be precisely tuned by mechanical rotations. The innovations reported in this research, from concept, design and actuation to application, are relevant to nanoelectromechanical system, nanomedicine, microfluidics and lab-on-a-chip architectures.

  18. Development and characterization of a modular acquisition system for a 4D PET block detector

    International Nuclear Information System (INIS)

    Next generation PET scanners should fulfill very high requirements in terms of spatial, energy and timing resolution. Modern scanner performances are inherently limited by the use of standard photomultiplier tubes. The use of Silicon Photomultiplier (SiPM) matrices is proposed for the construction of a 4D PET module based on LSO continuous crystals, which is envisaged to replace the standard PET block detector. The expected spatial resolution of the module for the photon hit position is below 1 mm, and it will perform at the same time, the Depth Of Interaction (DOI) calculation and the Time Of Flight (TOF) measurement. The use of large area multi-pixel Silicon Photomultiplier (SiPM) detectors requires the development of a multichannel Digital Acquisition system (DAQ) as well as of a dedicated front-end in order not to degrade the intrinsic detector performances. We have developed a flexible and modular DAQ system for the read-out of two modules in time coincidence for Positron Emission Tomography (PET) applications. The DAQ system is based on a previously developed custom front-end ASIC chip (BASIC) which allows to read-out SiPM matrices preserving their spectroscopy and timing capabilities. Here we describe the acquisition system architecture and its characterization measurements.

  19. Coding and signal processing for magnetic recording systems

    CERN Document Server

    Vasic, Bane

    2004-01-01

    RECORDING SYSTEMSA BriefHistory of Magnetic Storage, Dean PalmerPhysics of Longitudinal and Perpendicular Recording, Hong Zhou, Tom Roscamp, Roy Gustafson, Eric Boernern, and Roy ChantrellThe Physics of Optical Recording, William A. Challener and Terry W. McDanielHead Design Techniques for Recording Devices, Robert E. RottmayerCOMMUNICATION AND INFORMATION THEORY OF MAGNETIC RECORDING CHANNELSModeling the Recording Channel, Jaekyun MoonSignal and Noise Generation for Magnetic Recording Channel Simulations, Xueshi Yang and Erozan M. KurtasStatistical Analysis of Digital Signals and Systems, Dra

  20. Anti-Inflammatory Effects of Cumin Essential Oil by Blocking JNK, ERK, and NF-κB Signaling Pathways in LPS-Stimulated RAW 264.7 Cells

    Directory of Open Access Journals (Sweden)

    Juan Wei

    2015-01-01

    Full Text Available Cumin seeds (Cuminum cyminum L. have been commonly used in food flavoring and perfumery. In this study, cumin essential oil (CuEO extracted from seeds was employed to investigate the anti-inflammatory effects in lipopolysaccharide- (LPS- stimulated RAW 264.7 cells and the underlying mechanisms. A total of 26 volatile constituents were identified in CuEO by GC-MS, and the most abundant constituent was cuminaldehyde (48.773%. Mitochondrial-respiration-dependent 3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium (MTT reduction assay demonstrated that CuEO did not exhibit any cytotoxic effect at the employed concentrations (0.0005–0.01%. Real-time PCR tests showed that CuEO significantly inhibited the mRNA expressions of inducible nitric oxide synthase (iNOS, cyclooxygenase (COX-2, interleukin- (IL- 1, and IL-6. Moreover, western blotting analysis revealed that CuEO blocked LPS-induced transcriptional activation of nuclear factor-kappa B (NF-κB and inhibited the phosphorylation of extracellular signal regulated kinase (ERK and c-Jun N-terminal kinase (JNK. These results suggested that CuEO exerted anti-inflammatory effects in LPS-stimulated RAW 264.7 cells via inhibition of NF-κB and mitogen-activated protein kinases ERK and JNK signaling; the chemical could be used as a source of anti-inflammatory agents as well as dietary complement for health promotion.

  1. Anti-Inflammatory Effects of Cumin Essential Oil by Blocking JNK, ERK, and NF-κB Signaling Pathways in LPS-Stimulated RAW 264.7 Cells.

    Science.gov (United States)

    Wei, Juan; Zhang, Xitong; Bi, Yang; Miao, Ruidong; Zhang, Zhong; Su, Hailan

    2015-01-01

    Cumin seeds (Cuminum cyminum L.) have been commonly used in food flavoring and perfumery. In this study, cumin essential oil (CuEO) extracted from seeds was employed to investigate the anti-inflammatory effects in lipopolysaccharide- (LPS-) stimulated RAW 264.7 cells and the underlying mechanisms. A total of 26 volatile constituents were identified in CuEO by GC-MS, and the most abundant constituent was cuminaldehyde (48.773%). Mitochondrial-respiration-dependent 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) reduction assay demonstrated that CuEO did not exhibit any cytotoxic effect at the employed concentrations (0.0005-0.01%). Real-time PCR tests showed that CuEO significantly inhibited the mRNA expressions of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2), interleukin- (IL-) 1, and IL-6. Moreover, western blotting analysis revealed that CuEO blocked LPS-induced transcriptional activation of nuclear factor-kappa B (NF-κB) and inhibited the phosphorylation of extracellular signal regulated kinase (ERK) and c-Jun N-terminal kinase (JNK). These results suggested that CuEO exerted anti-inflammatory effects in LPS-stimulated RAW 264.7 cells via inhibition of NF-κB and mitogen-activated protein kinases ERK and JNK signaling; the chemical could be used as a source of anti-inflammatory agents as well as dietary complement for health promotion. PMID:26425131

  2. On dynamics of seismicity simulated by the models of blocks-and-faults systems

    Directory of Open Access Journals (Sweden)

    I. A. Vorobieva

    1997-06-01

    Full Text Available The major results obtained by numerical simulation of block structure dynamics are juxtaposed and analysed: the possibilities to reconstruct tectonic driving forces from territorial distribution of seismicity, clustering of earthquakes in the model, and dependence of the occurrence of strong earthquakes on fragmentation of the media, and on rotation of blocks. These results show that modelling of block structure dynamics is a useful tool to study relations between the geometry of faults and block movements and earthquake flow, including premonitory seismicity patterns, to test the existing earthquake prediction algorithms, and to develop new ones.

  3. Signal to Interference Ratio Based Handoff Management for Next-Generation Wireless Systems

    Directory of Open Access Journals (Sweden)

    Utpal Biswas

    2010-04-01

    Full Text Available Next-generation wireless systems (NGWS integrate different wireless networks, each of which is optimized for some specific services such as WLANs, WiMAX, General Packet Radio Service (GPRS and Universal Mobile Telecommunications System (UMTS. The most important and challenging issue is seamless handoff management in NGWS to ensure the Quality of Service (QoS. In this paper, we propose a handoff management architecture using signal to interference ratio of the present and neighboring base stations. This handoff management scheme uses mobile’s speed, handoff signaling delay information and also the size of the present and neighboring cell to enhance the handoff performance. In our proposed work we use the signal to interferenceratio threshold values between present base station in which the mobile terminal is served and its neighboring stations. The simulation results show that our proposed mechanism supports mobility management in wireless IP networks and significantly enhances the handoff performance for both intra and intersystem handoffs reducing false handoff initiation and unnecessary call blocking probability.

  4. A Segmented Signal Progression Model for the Modern Streetcar System

    Directory of Open Access Journals (Sweden)

    Baojie Wang

    2015-01-01

    Full Text Available This paper is on the purpose of developing a segmented signal progression model for modern streetcar system. The new method is presented with the following features: (1 the control concept is based on the assumption of only one streetcar line operating along an arterial under a constant headway and no bandwidth demand for streetcar system signal progression; (2 the control unit is defined as a coordinated intersection group associated with several streetcar stations, and the control joints must be streetcar stations; (3 the objective function is built to ensure the two-way streetcar arrival times distributing within the available time of streetcar phase; (4 the available time of streetcar phase is determined by timing schemes, intersection structures, track locations, streetcar speeds, and vehicular accelerations; (5 the streetcar running speed is constant separately whether it is in upstream or downstream route; (6 the streetcar dwell time is preset according to historical data distribution or charging demand. The proposed method is experimentally examined in Hexi New City Streetcar Project in Nanjing, China. In the experimental results, the streetcar system operation and the progression impacts are shown to affect transit and vehicular traffic. The proposed model presents promising outcomes through the design of streetcar system segmented signal progression, in terms of ensuring high streetcar system efficiency and minimizing negative impacts on transit and vehicular traffic.

  5. Hierarchically Ordered Polymer/Block Copolymer/Nanoparticle Systems Enabled via Holographic Photopolymerization

    Science.gov (United States)

    Bunning, Timothy

    2010-03-01

    Combining top-down and bottom-up methods in one process step creates novel hierarchical nanostructures with tailored properties. We demonstrate the ability to spatially pattern block copolymers or nanoparticles into periodic volume gratings using a one-step holographic patterning (HP) technique. The confinement of the second phase (e.g. block copolymer or nanoparticle) within the grating results in local preferential ordering of that phase, enabling single-step fabrication of complex hierarchical structures. As an example, this simple interfering photopolymer `writing' technique was utilized to generate a layer-in-layer structure of poly(ethylene oxide-b-epsilon-caprolactone) confined between crosslinked resin. The period of the volume grating was 200 nm, with the BCP occupying 100 nm of the 1-D structure. The BCP crystallized/phase separated to produce a lamellar structure with a 21 nm periodicity. This system exhibits interesting thermo-optical behavior during heating/cooling cycles. Alternatively, a layered polymer/nanoparticle composite was created through a one-step two-beam interference lithographic exposure of a dispersion of silica nanoparticles within a photopolymerizable mixture at a wavelength of 532 nm. The effects of exposure time and power, nanoparticle size, and periodicity on the nanocomposite structure were measured with transmission electron microscopy. The optical properties of the formed gratings were probed in real-time during formation. Collaborators on this work include M. Birnkrant and C. Li from Drexel University, A. Juhl and P. Braun from UIUC, and L. Natarajan, V. Tondiglia, and R. Vaia from AFRL.

  6. Fixed-complexity vector perturbation with Block diagonalization for MU-MIMO systems

    CERN Document Server

    Mohaisen, Manar; Chang, KyungHi; Ji, Seunghwan; Joung, Jinsoup

    2009-01-01

    Block diagonalization (BD) is an attractive technique that transforms the multi-user multiple-input multiple-output (MU-MIMO) channel into parallel single-user MIMO (SU-MIMO) channels with zero inter-user interference (IUI). In this paper, we combine the BD technique with two deterministic vector perturbation (VP) algorithms that reduce the transmit power in MU-MIMO systems with linear precoding. These techniques are the fixed-complexity sphere encoder (FSE) and the QR-decomposition with M-algorithm encoder (QRDM-E). In contrast to the conventional BD VP technique, which is based on the sphere encoder (SE), the proposed techniques have fixed complexity and a tradeoff between performance and complexity can be achieved by controlling the size of the set of candidates for the perturbation vector. Simulation results and analysis demonstrate the properness of the proposed techniques for the next generation mobile communications systems which are latency and computational complexity limited. In MU-MIMO system with ...

  7. Correlation between peak and median blocking temperatures by magnetization measurement on isolated ferromagnetic and antiferromagnetic particle systems

    DEFF Research Database (Denmark)

    Jiang, Jianzhong; Mørup, Steen

    1997-01-01

    The influence of the particle size distribution on the ratio of the peak temperature, T-peak, to the blocking temperature, T-Bm, in zero field cooled (ZFD) magnetization curves has studied for both ferromagnetic and antiferromagnetic particle systems. In both systems the ratio beta=T-peak/T-Bm do...

  8. The application of information theory to biochemical signaling systems

    International Nuclear Information System (INIS)

    Cell signaling can be thought of fundamentally as an information transmission problem in which chemical messengers relay information about the external environment to the decision centers within a cell. Due to the biochemical nature of cellular signal transduction networks, molecular noise will inevitably limit the fidelity of any messages received and processed by a cell's signal transduction networks, leaving it with an imperfect impression of its environment. Fortunately, Shannon's information theory provides a mathematical framework independent of network complexity that can quantify the amount of information that can be transmitted despite biochemical noise. In particular, the channel capacity can be used to measure the maximum number of stimuli a cell can distinguish based upon the noisy responses of its signaling systems. Here, we provide a primer for quantitative biologists that covers fundamental concepts of information theory, highlights several key considerations when experimentally measuring channel capacity, and describes successful examples of the application of information theoretic analysis to biological signaling. (paper)

  9. Overlay mark optimization using the KTD signal simulation system

    Science.gov (United States)

    Marchelli, Anat; Gutjahr, Karsten; Kubis, Michael; Sparka, Christian; Ghinovker, Mark; Navarra, Alessandra; Widmann, Amir

    2009-03-01

    As the overlay performance and accuracy requirements become tighter, the impact of process parameters on the target signal becomes more significant. Traditionally, in order to choose the optimum overlay target, several candidates are placed in the kerf area. The candidate targets are tested under different process conditions, before the target to be used in mass production is selected. The varieties of targets are left on the mass production mask and although they will not be used for overlay measurements they still consume kerf real estate. To improve the efficiency of the process we are proposing the KTD (KLA-Tencor Target Designer). It is an easy to use system that enables the user to select the optimum target based on advanced signal simulation. Implementing the KTD in production is expected to save 30% of kerf real estate due to more efficient target design process as well as reduced engineering time. In this work we demonstrate the capability of the KTD to simulate the Archer signal in the context of advanced DRAM processes. For several stacks we are comparing simulated target signals with the Archer100 signals. We demonstrate the robustness feature in the KTD application that enables the user to test the target sensitivity to process changes. The results indicate the benefit of using KTD in the target optimization process.

  10. A peptide targeting an interaction interface disrupts the dopamine D1-D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism

    Science.gov (United States)

    Hasbi, Ahmed; Perreault, Melissa L.; Shen, Maurice Y. F.; Zhang, Lucia; To, Ryan; Fan, Theresa; Nguyen, Tuan; Ji, Xiaodong; O'Dowd, Brian F.; George, Susan R.

    2014-01-01

    Although the dopamine D1-D2 receptor heteromer has emerging physiological relevance and a postulated role in different neuropsychiatric disorders, such as drug addiction, depression, and schizophrenia, there is a need for pharmacological tools that selectively target such receptor complexes in order to analyze their biological and pathophysiological functions. Since no selective antagonists for the D1-D2 heteromer are available, serial deletions and point mutations were used to precisely identify the amino acids involved in an interaction interface between the receptors, residing within the carboxyl tail of the D1 receptor that interacted with the D2 receptor to form the D1-D2 receptor heteromer. It was determined that D1 receptor carboxyl tail residues 404Glu and 405Glu were critical in mediating the interaction with the D2 receptor. Isolated mutation of these residues in the D1 receptor resulted in the loss of agonist activation of the calcium signaling pathway mediated through the D1-D2 receptor heteromer. The physical interaction between the D1 and D2 receptor could be disrupted, as shown by coimmunoprecipitation and BRET analysis, by a small peptide generated from the D1 receptor sequence that contained these amino acids, leading to a switch in G-protein affinities and loss of calcium signaling, resulting in the inhibition of D1-D2 heteromer function. The use of the D1-D2 heteromer-disrupting peptide in vivo revealed a pathophysiological role for the D1-D2 heteromer in the modulation of behavioral despair. This peptide may represent a novel pharmacological tool with potential therapeutic benefits in depression treatment.—Hasbi, A., Perreault, M. L., Shen, M. Y. F., Zhang, L., To, R., Fan, T., Nguyen, T., Ji, X., O'Dowd, B. F., George, S. R. A peptide targeting an interaction interface disrupts the dopamine D1-D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism. PMID:25063849

  11. Plural image signal system for scanning x-ray apparatus

    International Nuclear Information System (INIS)

    Radiographic images are produced by situating a subject (13) between a scanning x-ray source (16) and an x-ray detector (14) to produce electrical signals indicative of variations of x-ray transmissivity in different regions of the subject (13). A signal processing system (11) enables simultaneous display of a plurality of visible images at a plurality of display devices (52 to 55) with each image emphasizing a different aspect of the information generated by a given scanning of the subject. A feedback circuit (68) from the detector (14) to the x-ray source (16) maintains the average level of the detector signal constant while allowing short term fluctuations so that only abrupt or brief changes of x-ray transmissivity in the subject are visible in a first image at a first display device (52). A second image signal circuit (93) recovers the data suppressed by the feedback circuit (68) to enable a full contrast range image to be presented at another display device (53) and to enableines of an ultrasonic image and for later reading-out of stored lines via the dbye chosen metal dihalide vapor is ionized by ; the total economic market potential is 64.4% of the technical potential, or 2072.4 MW, equivalent to 83,621 BPDE; and the lack of an operating history-detailing system reliability, safety, and operating costs-iment and test components; technology testing; analytmperature fatigue stren obtained

  12. Accelerated direct solution of the MoM linear system using block compression and nested factorization

    OpenAIRE

    Heldring, Alexander; Rius Casals, Juan Manuel

    2011-01-01

    A comparison is presented between different algorithms for direct (non-iterative) accelerated solution of the Method of Moments. The alternatives are common block LU factorization and Compressed Block Decomposition (CBD), and their respective nested, or Multi Scale (MS) implementations. The comparison includes theoretical considerations and numerical examples.

  13. Joint Polar Satellite System (JPSS) Common Ground System (CGS) Block 3.0 Communications Strategies

    Science.gov (United States)

    Miller, S. W.; Grant, K. D.; Ottinger, K.

    2015-12-01

    The National Oceanic and Atmospheric Administration (NOAA) and National Aeronautics and Space Administration (NASA) are jointly acquiring the next-generation civilian weather and environmental satellite system: the Joint Polar Satellite System (JPSS). The JPSS program is the follow-on for both space and ground systems to the Polar-orbiting Operational Environmental Satellites (POES) managed by NOAA. The JPSS satellites will carry a suite of sensors designed to collect meteorological, oceanographic, climatological and geophysical observations of the Earth. The ground processing system for JPSS is known as the JPSS Common Ground System (JPSS CGS). Developed and maintained by Raytheon Intelligence, Information and Services (IIS), the CGS is a globally distributed, multi-mission system serving NOAA, NASA and their national and international partners. The CGS has demonstrated its scalability and flexibility to incorporate multiple missions efficiently and with minimal cost, schedule and risk, while strengthening global partnerships in weather and environmental monitoring. In a highly successful international partnership between NOAA and the European Organisation for the Exploitation of Meteorological Satellites (EUMETSAT), the CGS currently provides data routing from McMurdo Station in Antarctica to the EUMETSAT processing center in Darmstadt, Germany. Continuing and building upon that partnership, NOAA and EUMETSAT are collaborating on the development of a new path forward for the 2020's. One approach being explored is a concept of operations where each organization shares satellite downlink resources with the other. This paper will describe that approach, as well as modeling results that demonstrate its feasibility and expected performance.

  14. Long-distance digital signal transfers between trigger system and TOF system of BES III

    International Nuclear Information System (INIS)

    This article introduces a design of digital signals communication between the trigger system and the TOF system of BES III. The design can support the BES III successfully, which is based on fiber digital communication, FPGA etc. (authors)

  15. Performance of a Heating Block System Designed for Studying the Heat Resistance of Bacteria in Foods.

    Science.gov (United States)

    Kou, Xiao-Xi; Li, Rui; Hou, Li-Xia; Huang, Zhi; Ling, Bo; Wang, Shao-Jin

    2016-01-01

    Knowledge of bacteria's heat resistance is essential for developing effective thermal treatments. Choosing an appropriate test method is important to accurately determine bacteria's heat resistances. Although being a major factor to influence the thermo-tolerance of bacteria, the heating rate in samples cannot be controlled in water or oil bath methods due to main dependence on sample's thermal properties. A heating block system (HBS) was designed to regulate the heating rates in liquid, semi-solid and solid foods using a temperature controller. Distilled water, apple juice, mashed potato, almond powder and beef were selected to evaluate the HBS's performance by experiment and computer simulation. The results showed that the heating rates of 1, 5 and 10 °C/min with final set-point temperatures and holding times could be easily and precisely achieved in five selected food materials. A good agreement in sample central temperature profiles was obtained under various heating rates between experiment and simulation. The experimental and simulated results showed that the HBS could provide a sufficiently uniform heating environment in food samples. The effect of heating rate on bacterial thermal resistance was evaluated with the HBS. The system may hold potential applications for rapid and accurate assessments of bacteria's thermo-tolerances. PMID:27465120

  16. Develop advanced nonlinear signal analysis topographical mapping system

    Science.gov (United States)

    1994-01-01

    The Space Shuttle Main Engine (SSME) has been undergoing extensive flight certification and developmental testing, which involves some 250 health monitoring measurements. Under the severe temperature, pressure, and dynamic environments sustained during operation, numerous major component failures have occurred, resulting in extensive engine hardware damage and scheduling losses. To enhance SSME safety and reliability, detailed analysis and evaluation of the measurements signal are mandatory to assess its dynamic characteristics and operational condition. Efficient and reliable signal detection techniques will reduce catastrophic system failure risks and expedite the evaluation of both flight and ground test data, and thereby reduce launch turn-around time. The basic objective of this contract are threefold: (1) develop and validate a hierarchy of innovative signal analysis techniques for nonlinear and nonstationary time-frequency analysis. Performance evaluation will be carried out through detailed analysis of extensive SSME static firing and flight data. These techniques will be incorporated into a fully automated system; (2) develop an advanced nonlinear signal analysis topographical mapping system (ATMS) to generate a Compressed SSME TOPO Data Base (CSTDB). This ATMS system will convert tremendous amount of complex vibration signals from the entire SSME test history into a bank of succinct image-like patterns while retaining all respective phase information. High compression ratio can be achieved to allow minimal storage requirement, while providing fast signature retrieval, pattern comparison, and identification capabilities; and (3) integrate the nonlinear correlation techniques into the CSTDB data base with compatible TOPO input data format. Such integrated ATMS system will provide the large test archives necessary for quick signature comparison. This study will provide timely assessment of SSME component operational status, identify probable causes of

  17. THE RESTRICTIVELY PRECONDITIONED CONJUGATE GRADIENT METHODS ON NORMAL RESIDUAL FOR BLOCK TWO-BY-TWO LINEAR SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    Junfeng Yin; Zhongzhi Bai

    2008-01-01

    The restrictively preconditioned conjugate gradient (RPCG) method is further developed to solve large sparse system of linear equations of a block two-by-two structure.The basic idea of this new approach is that we apply the RPCG method to the normal-residual equation of the block two-by-two linear system and construct each required approximate matrix by making use of the incomplete orthogonal factorization of the involved matrix blocks.Numerical experiments show that the new method,called the restrictively preconditioned conjugate gradient on normal residual (RPCGNR),is more robust and effective than either the known RPCG method or the standard conjugate gradient on normal residual (CGNR) method when being used for solving the large sparse saddle point problems.

  18. CXCL12 Signaling in the Development of the Nervous System

    Science.gov (United States)

    Mithal, Divakar S.; Banisadr, Ghazal; Miller, Richard J.

    2015-01-01

    Chemokines are small, secreted proteins that have been shown to be important regulators of leukocyte trafficking and inflammation. All the known effects of chemokines are transduced by action at a family of G protein coupled receptors. Two of these receptors, CCR5 and CXCR4, are also known to be the major cellular receptors for HIV-1. Consideration of the evolution of the chemokine family has demonstrated that the chemokine Stromal cell Derived Factor-1 or SDF1 (CXCL12) and its receptor CXCR4 are the most ancient members of the family and existed in animals prior to the development of a sophisticated immune system. Thus, it appears that the original function of chemokine signaling was in the regulation of stem cell trafficking and development. CXCR4 signaling is important in the development of many tissues including the nervous system. Here we discuss the manner in which CXCR4 signaling can regulate the development of different structures in the central and peripheral nervous systems and the different strategies employed to achieve these effects. PMID:22270883

  19. Design principles of paradoxical signaling in the immune system

    Science.gov (United States)

    Hart, Yuval

    A widespread feature of cell-cell signaling systems is paradoxical pleiotropy: the same secreted signaling molecule can induce opposite effects in the responding cells. For example, the cytokine IL-2 can promote proliferation and death of T-cells. The role of such paradoxical signaling remains unclear. We suggest that this mechanism provides homeostatic concentration of cells, independent of initial conditions. The crux of the paradoxical mechanism is the combination of a positive and a negative feedback loops creating two stable states - an OFF state and an ON state. Experimentally, we found that CD4 + cells grown in culture with a 30-fold difference in initial concentrations reached a homeostatic concentration nearly independent of initial cell levels (ON-state). Below an initial threshold, cell density decayed to extinction (OFF-state). Mathematical modeling explained the observed cell and cytokine dynamics and predicted conditions that shifted cell fate from homeostasis to the OFF-state. We suggest that paradoxical signaling provides cell circuits with specific dynamical features that are robust to environmental perturbations.

  20. Power and signal transmission for mobile teleoperated systems

    International Nuclear Information System (INIS)

    Appropriate means must be furnished for supplying power and for sending controlling commands to mobile teleoperated systems. Because a sizable number of possibilities are available for such applications, methods used in designing both the power and communications systems built into mobile vehicles that serve in radiological emergencies must be carefully selected. This paper describes a number of umbilical, on-board, and wireless systems used in tranmitting power that are available for mobile teleoperator services. The pros and cons of selecting appropriate methods from a list of possible communication systems (wired, fiber optic, and radio frequency) are also examined. Moreover, hybrid systems combining wireless power transmissions with command-information signals are also possible

  1. Positioning models and systems based on digital television broadcasting signals

    Institute of Scientific and Technical Information of China (English)

    HE Feng; WU Lenan

    2007-01-01

    The requirement and feasibility of the positioning system using digital television(DTV)broadcasting signals are analyzed.The principle of DTV positioning on the basis of frame synchronization is brought forward and the ranging characteristic is studied that the observables are asynchronously measured during the same epoch interval.The models of the pseudo-range observation and Doppler carrier phase integral are researched.The system observation and state equations are presented on the basis of the above models.The simulation results showed that DTV positioning technology could remarkably improve the precision of system state estimates using smoothing methods for positioning systems or integrated navigation systems.The DTV positioning that has a sub-meter level ranging error and meter level positioning accuracy can parallel with and even taken as a beneficial substitute for the tradition positioning technology.

  2. FireSignal - Data Acquisition and Control System Software

    International Nuclear Information System (INIS)

    Control of fusion devices requires good, non-ambiguous, easy to use user-interfaces to configure hardware devices. To solve this problem a highly generic system for data control and acquisition has been developed. Among the main features it allows remote hardware configuration, shot launching, data sharing between connected users and experiment monitoring. The system is fully distributed: the hardware driver nodes, clients and server are completely independent from each other and might be running in different operating systems and programmed in different languages. All the communication is provided through the Common Object Request Broker Architecture (CORBA) protocol. FireSignal was designed from the beginning to be as independent as possible from any kind of constraints as it's a plugin based system. Database, data viewers and the security system are some examples of what can easily be changed and adapted to the target machine's needs. All hardware is described in eXtendend Markup Language (XML) and from this information the FireSignal client application can build automatically Graphical User Interfaces (GUI) and validate the user's parameter configuration. Any type of hardware can be integrated in the system as long as it is described in XML and the respective driver is developed. Any modern programming language can be used to develop these drivers, and currently we use Python and Java generic drivers. All data storage and indexing is time stamped event-based s. Nodes are responsible for tagging the acquired samples with the absolute time stamps and to react to machine events. FireSignal is currently being used to control the ISTTOK/PT and CASTOR/CZ tokamaks. (author)

  3. Environment-induced self-assembly in phase separated block copolymer systems: A SANS investigation

    International Nuclear Information System (INIS)

    In this research, we examine the effect of non-selective solvent on the large-scale mesoscopic ordering in asymmetric block copolymers, poly(styrene-block-ethylene/butylene-block-styrene) (SEBS) using small angle neutron scattering technique (SANS). SANS measurements were carried out over a wide range of concentrations and temperatures. Evolution of the self-assembled phase morphology in such polymer with the thermodynamic selectivity of solvent, temperature and concentration has been discussed. Correlation between morphology and thermorheological behavior of the gels has also been established

  4. Photonics for microwave systems and ultra-wideband signal processing

    Science.gov (United States)

    Ng, W.

    2016-08-01

    The advantages of using the broadband and low-loss distribution attributes of photonics to enhance the signal processing and sensing capabilities of microwave systems are well known. In this paper, we review the progress made in the topical areas of true-time-delay beamsteering, photonic-assisted analog-to-digital conversion, RF-photonic filtering and link performances. We also provide an outlook on the emerging field of integrated microwave photonics (MWP) that promise to reduce the cost of MWP subsystems and components, while providing significantly improved form-factors for system insertion.

  5. Signal Processing System for the CASA Integrated Project I Radars

    Energy Technology Data Exchange (ETDEWEB)

    Bharadwaj, Nitin; Chandrasekar, V.; Junyent, Francesc

    2010-09-01

    This paper describes the waveform design space and signal processing system for dual-polarization Doppler weather radar operating at X band. The performance of the waveforms is presented with ground clutter suppression capability and mitigation of range velocity ambiguity. The operational waveform is designed based on operational requirements and system/hardware requirements. A dual Pulse Repetition Frequency (PRF) waveform was developed and implemented for the first generation X-band radars deployed by the Center for Collaborative Adaptive Sensing of the Atmosphere (CASA). This paper presents an evaluation of the performance of the waveforms based on simulations and data collected by the first-generation CASA radars during operations.

  6. Imaging system for creating 3D block-face cryo-images of whole mice

    Science.gov (United States)

    Roy, Debashish; Breen, Michael; Salvado, Olivier; Heinzel, Meredith; McKinley, Eliot; Wilson, David

    2006-03-01

    We developed a cryomicrotome/imaging system that provides high resolution, high sensitivity block-face images of whole mice or excised organs, and applied it to a variety of biological applications. With this cryo-imaging system, we sectioned cryo-preserved tissues at 2-40 μm thickness and acquired high resolution brightfield and fluorescence images with microscopic in-plane resolution (as good as 1.2 μm). Brightfield images of normal and pathological anatomy show exquisite detail, especially in the abdominal cavity. Multi-planar reformatting and 3D renderings allow one to interrogate 3D structures. In this report, we present brightfield images of mouse anatomy, as well as 3D renderings of organs. For BPK mice model of polycystic kidney disease, we compared brightfield cryo-images and kidney volumes to MRI. The color images provided greater contrast and resolution of cysts as compared to in vivo MRI. We note that color cryo-images are closer to what a researcher sees in dissection, making it easier for them to interpret image data. The combination of field of view, depth of field, ultra high resolution and color/fluorescence contrast enables cryo-image volumes to provide details that cannot be found through in vivo imaging or other ex vivo optical imaging approaches. We believe that this novel imaging system will have applications that include identification of mouse phenotypes, characterization of diseases like blood vessel disease, kidney disease, and cancer, assessment of drug and gene therapy delivery and efficacy and validation of other imaging modalities.

  7. Novel layered two-dimensional semiconductors as the building blocks for nano-electronic/photonic systems

    Science.gov (United States)

    Su, Guoxiong; De, Debtanu; Hadjiev, Viktor G.; Peng, Haibing

    2014-06-01

    Layered two-dimensional (2D) semiconductors beyond graphene have been emerging as potential building blocks for the next-generation electronic/photonic applications. Representative metal chalcogenides, including the widely studied MoS2, possess similar layered crystal structures with weak interaction between adjacent layers, thus allowing the formation of stable thin-layer crystals with thickness down to a few or even single atomic layer. Other important chalcogenides, involving earth-abundant and environment-friendly materials desirable for sustainable applications, include SnS2 (band gap: 2.1 eV) and SnS (band gap: 1.1 eV). So far, commonly adopted for research purpose are mechanical and liquid exfoliation methods for creating thin layers of such 2D semiconductors. Most recently, chemical vapor deposition (CVD) was attracting significant attention as a practical method for producing thin films or crystal grains of MoS2. However, critical yet still absent is an effective experimental approach for controlling the positions of thin crystal grains of layered 2D semiconductors during the CVD process. Here we report the controlled CVD synthesis of thin crystal arrays of representative layered semiconductors (including SnS2 and SnS) at designed locations on chip, promising large-scale optoelectronic applications. Our work opens a window for future practical applications of layered 2D semiconductors in integrated nano-electronic/photonic systems.

  8. Curing kinetics and morphology of a nanovesicular epoxy/stearyl-block-poly(ethylene oxide) surfactant system.

    Science.gov (United States)

    Bogaerts, K; Lavrenova, A; Spoelstra, A B; Boyard, N; Goderis, B

    2015-08-21

    Brittle epoxy based thermosets can be made tougher by introducing structural inhomogeneities at the micro- or nanoscale. In that respect, nano vesicles and worm-like micelles from self-assembling blockcopolymers have been shown to be very effective. This paper describes the curing kinetics and morphology of an epoxy composed of diglycidyl ether of bisphenol A (DGEBA) and 4,4'-methylenedianiline (MDA), modified by 20% of the surfactant stearyl-block-poly(ethylene oxide). Time resolved, synchrotron small-angle X-ray scattering demonstrates that at any time during the epoxy curing process, the surfactant predominantly adopts a bilayer vesicular nano-morphology. Transmission electron microscopy on fully cured systems reveals the coexistence of spherical and worm-like micelles. Differential scanning calorimetry experiments prove that the presence of surfactant reduces the epoxy curing rate but that ultimately full curing is accomplished. The material glass transition temperature falls below that of the pure resin due to plasticization. It is suggested that favorable secondary interactions between the PEO segments and the epoxy resin are responsible for the observed phenomena. PMID:26144526

  9. Hepatic venous outflow block in a young patient with Systemic Lupus Erythematosus

    Directory of Open Access Journals (Sweden)

    Ali Ghavidel

    2015-08-01

    Full Text Available Introduction: Hepatic venous outflow block or Budd-Chiari syndrome is a severe liver disease with a 3 years survival rate of 50%. Several conditions have been implicated as a cause of Budd-Chiari syndrome, including myeloproliferative disorders, paroxysmal nocturnal hemoglobinuria, the presence of lupus anti-coagulant, oral contraceptives, pregnancy, and others. In a small number of cases, Budd-Chiari syndrome is associated with the presence of lupus anticoagulant. Anticardiolipin antibodies (ACA are similar to lupus anti-coagulant antiphospholipid antibodies (APLAs, which have been described in patients with recurrent arterial and venous thrombosis, thrombocytopenia, fetal loss, or miscarriage. Case Report: A 23-year-old woman is reported with Budd-Chiari syndrome in whom lupus anticoagulant and anticardiolipin antibodies were shown; 9 months after diagnosis of systemic lupus erythematosus (SLE treatment with steroids admitted with gastrointestinal problems, abdominal pain and ascites and treated oral anticoagulants induced a considerable improvement. This treatment was continued after 1 year, but interruption was followed by redevelopment of ascites. Further treatment with anticoagulants was continued for 5 years with noticeable improvement. Conclusion: Patients with Budd-Chiari syndrome should be tested for lupus anticoagulants and anticardiolipin antibodies, Budd-Chiari syndrome resulting from this cause may have a good response to treatment with oral anticoagulants; this treatment should be maintained permanently, and pregnancy in such patients may initiate serious difficulties. The condition of the patient at follow-up was good.

  10. Development of an electronic system for signals amplification

    International Nuclear Information System (INIS)

    This paper presents the obtained results with a spectrometer for electromagnetic radiation whose detector, a Si PIN type diode, was directly coupled to a signal amplification system developed in this project for scientific initiation. The linearity conditions and the gain operational limits, constituted of two stages of amplification based on the employment of devices from AMTEK A225 and A206, were determined using a precision pulse generator. The obtained results shown that the developed system is stable and linear in the gain range of 50-150. The spectrometric response of the electronic system coupled to the Siemens SFH-00206 type diode, were studied in view of the register of the 59.5 keV gamma ray spectra proceeding from 241Am as function of the reversal polarization voltage. The influence pf the voltage and the electronic contribution in the energy resolution of the registered spectra under room temperature (22 degree Celsius) had also investigated considering the more adequate value of the coupling capacitance of the amplification system diode. Up to the present. the best energy resolution (FWHM = 4.85 keV) of the 59.5 keV line was obtained for the condition of the detector polarization at 16 V. This result proves that the signal amplification system developed coupled to the SFH00206 diode, besides the low cost, excellent operational condition for the detection and spectrometry or low energy electromagnetic radiation

  11. Nonlinear signal processing using neural networks: Prediction and system modelling

    Energy Technology Data Exchange (ETDEWEB)

    Lapedes, A.; Farber, R.

    1987-06-01

    The backpropagation learning algorithm for neural networks is developed into a formalism for nonlinear signal processing. We illustrate the method by selecting two common topics in signal processing, prediction and system modelling, and show that nonlinear applications can be handled extremely well by using neural networks. The formalism is a natural, nonlinear extension of the linear Least Mean Squares algorithm commonly used in adaptive signal processing. Simulations are presented that document the additional performance achieved by using nonlinear neural networks. First, we demonstrate that the formalism may be used to predict points in a highly chaotic time series with orders of magnitude increase in accuracy over conventional methods including the Linear Predictive Method and the Gabor-Volterra-Weiner Polynomial Method. Deterministic chaos is thought to be involved in many physical situations including the onset of turbulence in fluids, chemical reactions and plasma physics. Secondly, we demonstrate the use of the formalism in nonlinear system modelling by providing a graphic example in which it is clear that the neural network has accurately modelled the nonlinear transfer function. It is interesting to note that the formalism provides explicit, analytic, global, approximations to the nonlinear maps underlying the various time series. Furthermore, the neural net seems to be extremely parsimonious in its requirements for data points from the time series. We show that the neural net is able to perform well because it globally approximates the relevant maps by performing a kind of generalized mode decomposition of the maps. 24 refs., 13 figs.

  12. Development of a signal processing system applicable in nuclear spectrometry

    International Nuclear Information System (INIS)

    Part 1: Study of noise sources in a spectrometry chain. This work analyses the various sources of noise present in the charge preamplifier and in the radiation detector. A study is made both of the physical processes responsible for the noise, and of their localisation. The behaviour of the field effect transistor constituting the preamplifier input is studied as a function of temperature. Part 2: Study of a system for processing the signal used in γ spectrometry. In this work a theoretical study is made of a system for processing the signal produced by a spectrometry chain. The processing is of the type ∫0T P(t)...dt in which P(t) is a qualified weighting function deduced from the theoretical weighting function, giving the optimum processing from the point of view of the minimum quadratic error criterion. The degradation of the signal to noise ratio is studied as a function of the degree of quantification. The effect of time dispersion on the time of departure of the analysis is studied. The theory is verified by experimental measurements. (author)

  13. The signal connections in robot integrated manufacturing systems

    Directory of Open Access Journals (Sweden)

    D. Reclik

    2008-01-01

    Full Text Available Purpose: The main goal of this paper is that, the robot integrated manufacturing systems are more popular and useful in the industry. Moreover, the communication in those systems might be realized by many different data exchange solutions. Using this kind of solution causes the data exchange incompatibility. This paper deals with different ways in informatics connection of all of the components in robot integrated manufacturing system.Design/methodology/approach: Incompatibility is a result of usage many different communication systems between components in lathe center. The way of mutual signal connections were the target of researches.Findings: As a result of scientific work, the universal and compatible informatics connection system of the robot lathe center was created.Research limitations/implications: The project of the data exchange system is confined to PROFIBUS DP lan.Practical implications: The result of the researches was developing a technical element choice procedure of the data exchange depending on transport means quantity and system composition in the robot lathe system.Originality/value: This is a brand new paper, which describes internal systems of data exchange in robot integrated manufacturing system in example of automatic lathe center.

  14. Blocking protein phosphatase 2A signaling prevents endothelial-to-mesenchymal transition and renal fibrosis: a peptide-based drug therapy

    Science.gov (United States)

    Deng, Yuanjun; Guo, Yanyan; Liu, Ping; Zeng, Rui; Ning, Yong; Pei, Guangchang; Li, Yueqiang; Chen, Meixue; Guo, Shuiming; Li, Xiaoqing; Han, Min; Xu, Gang

    2016-01-01

    Endothelial-to-mesenchymal transition (EndMT) contributes to the emergence of fibroblasts and plays a significant role in renal interstitial fibrosis. Protein phosphatase 2A (PP2A) is a major serine/threonine protein phosphatase in eukaryotic cells and regulates many signaling pathways. However, the significance of PP2A in EndMT is poorly understood. In present study, the role of PP2A in EndMT was evaluated. We demonstrated that PP2A activated in endothelial cells (EC) during their EndMT phenotype acquisition and in the mouse model of obstructive nephropathy (i.e., UUO). Inhibition of PP2A activity by its specific inhibitor prevented EC undergoing EndMT. Importantly, PP2A activation was dependent on tyrosine nitration at 127 in the catalytic subunit of PP2A (PP2Ac). Our renal-protective strategy was to block tyrosine127 nitration to inhibit PP2A activation by using a mimic peptide derived from PP2Ac conjugating a cell penetrating peptide (CPP: TAT), termed TAT-Y127WT. Pretreatment withTAT-Y127WT was able to prevent TGF-β1-induced EndMT. Administration of the peptide to UUO mice significantly ameliorated renal EndMT level, with preserved density of peritubular capillaries and reduction in extracellular matrix deposition. Taken together, these results suggest that inhibiting PP2Ac nitration using a mimic peptide is a potential preventive strategy for EndMT in renal fibrosis.

  15. Non-Linear Detection for Joint Space-Frequency Block Coding and Spatial Multiplexing in OFDM-MIMO Systems

    DEFF Research Database (Denmark)

    Rahman, Imadur Mohamed; Marchetti, Nicola; Fitzek, Frank;

    2005-01-01

    In this work, we have analyzed a joint spatial diversity and multiplexing transmission structure for MIMO-OFDM system, where Orthogonal Space-Frequency Block Coding (OSFBC) is used across all spatial multiplexing branches. We have derived a BLAST-like non-linear Successive Interference Cancellation...

  16. Performance evaluation of block-diagonal preconditioners for the divergence-conforming B-spline discretization of the Stokes system

    KAUST Repository

    Côrtes, A.M.A.

    2015-02-20

    The recently introduced divergence-conforming B-spline discretizations allow the construction of smooth discrete velocity–pressure pairs for viscous incompressible flows that are at the same time inf-sup stable and pointwise divergence-free. When applied to discretized Stokes equations, these spaces generate a symmetric and indefinite saddle-point linear system. Krylov subspace methods are usually the most efficient procedures to solve such systems. One of such methods, for symmetric systems, is the Minimum Residual Method (MINRES). However, the efficiency and robustness of Krylov subspace methods is closely tied to appropriate preconditioning strategies. For the discrete Stokes system, in particular, block-diagonal strategies provide efficient preconditioners. In this article, we compare the performance of block-diagonal preconditioners for several block choices. We verify how the eigenvalue clustering promoted by the preconditioning strategies affects MINRES convergence. We also compare the number of iterations and wall-clock timings. We conclude that among the building blocks we tested, the strategy with relaxed inner conjugate gradients preconditioned with incomplete Cholesky provided the best results.

  17. A novel 300 kW arc plasma inverter system based on hierarchical controlled building block structure

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    To date, the high power arc plasma technology is widely used. A next generation high power arc plasma system based on building block structure is presented. The whole arc plasma inverter system is composed of 12 paralleled units to increase the system output capability. The hierarchical control system is adopted to improve the reliability and flexibility of the high power arc plasma inverter. To ensure the reliable turn on and off of the IGBT module in each building block unit, a special pulse drive circuit is designed by using pulse transformer. The experimental result indicates that the high power arc plasma inverter system can transfer 300 kW arc plasma energy reliably with high efficiency.

  18. A Miniaturized System for Neural Signal Acquiring and Processing

    Institute of Scientific and Technical Information of China (English)

    WANG Min; GAO Guang-hong; XIANG Dong-sheng; CAO Mao-yong; JIA Ai-bin; DING Lei; KONG Hui-min

    2008-01-01

    To collect neural activity data from awake, behaving freely animals, we develop miniaturized implantable recording system by the modern chip:Programmable System on Chip(PSoC) and through chronic electrodes in the cortex. With PSoC family member CY8C29466,the system completed operational and instrument amplifiers, filters, timers, AD convertors, and serial communication, etc. The signal processing was dealt with virtual instrument technology. All of these factors can significantly affect the price and development cycle of the project. The result showed that the system was able to record and analyze neural extrocellular discharge generated by neurons continuously for a week or more. This is very useful for the interdisciplinary research of neuroscience and information engineering technique.The circuits and architecture of the devices can be adapted for neurobiology and research with other small animals.

  19. Systemic mifepristone blocks reconsolidation of cue-conditioned fear; propranolol prevents this effect.

    Science.gov (United States)

    Pitman, Roger K; Milad, Mohammed R; Igoe, Sarah A; Vangel, Mark G; Orr, Scott P; Tsareva, Alina; Gamache, Karine; Nader, Karim

    2011-08-01

    Reducing reconsolidation of reactivated traumatic memories may offer a novel pharmacological treatment for posttraumatic stress disorder (PTSD). Preclinical research is needed to identify candidate drugs. We evaluated the ability of postreactivation mifepristone (RU38486, a glucocorticoid antagonist), alone and in combination with propranolol (a beta-adrenergic blocker), both given systemically, to reduce cue-conditioned fear in rats. On Day 1, a 30-s tone conditioned stimulus (CS) was paired with an electric shock unconditioned stimulus (US). On Day 2, the CS was presented without the US (reactivation), and the freezing conditioned response (CR) was measured. This was immediately followed by subcutaneous injection of vehicle, mifepristone 30 mg/kg, propranolol 10 mg/kg, or both. On Day 3, the CR was again measured as a test of postreactivation long-term memory (PR-LTM). On Day 10, the CR was again measured to evaluate spontaneous recovery. On Day 11, the US was presented alone (reinstatement). On Day 12, the CR was again measured. A fifth group received mifepristone without the CS presentation (nonreactivation) on Day 2. A sixth group was tested four hours after the Day 2 mifepristone injection to measure postreactivation short-term memory. Postreactivation, but not nonreactivation, mifepristone produced a decrement in the CR that did not undergo spontaneous recovery and underwent only modest reinstatement. Mifepristone did not exert its effect when administered concurrently with propranolol. Postreactivation mifepristone did not impair short-term memory. Systemic mifepristone blocks the reconsolidation of cue-conditioned fear in rats. Concurrent administration of propranolol prevents this effect. Postreactivation mifepristone may be a promising treatment for PTSD, but not necessarily in combination with propranolol. PMID:21688892

  20. Estimation of uncertainty of impedance function of SSI system based on existing comprehensive block-shaking test data

    International Nuclear Information System (INIS)

    Study on advanced seismic design for LWR has been carried out by the Nuclear Power Engineering Corporation (NUPEC), under the sponsorship of the Ministry of International Trade and Industry (MTTI) of Japan. Considerable number of soil-structure interaction (SSI) tests shaking large concrete block (block-shaking tests) have been carried out in various places in Japan to obtain soil-structure interaction data. The researchers compared their test results with analytical results in their papers. They have reached various conclusions reflecting their own test results. So, it is necessary to gather the data altogether and to have common knowledge as to the uncertainty between tests and analyses. This paper evaluates the uncertainty of impedance functions of SSI system based on the comprehensive existing block-shaking data. It also estimates the uncertainty of responses of reactor buildings due to the uncertainty of impedance functions

  1. An Optical Tomography System Using a Digital Signal Processor

    Science.gov (United States)

    Rahim, Ruzairi Abdul; Thiam, Chiam Kok; Fazalul Rahiman, Mohd Hafiz

    2008-01-01

    The use of a personal computer together with a Data Acquisition System (DAQ) as the processing tool in optical tomography systems has been the norm ever since the beginning of process tomography. However, advancements in silicon fabrication technology allow nowadays the fabrication of powerful Digital Signal Processors (DSP) at a reasonable cost. This allows this technology to be used in an optical tomography system since data acquisition and processing can be performed within the DSP. Thus, the dependency on a personal computer and a DAQ to sample and process the external signals can be reduced or even eliminated. The DSP system was customized to control the data acquisition process of 16×16 optical sensor array, arranged in parallel beam projection. The data collected was used to reconstruct the cross sectional image of the pipeline conveyor. For image display purposes, the reconstructed image was sent to a personal computer via serial communication. This allows the use of a laptop to display the tomogram image besides performing any other offline analysis.

  2. An Optical Tomography System Using a Digital Signal Processor

    Directory of Open Access Journals (Sweden)

    Mohd. Hafiz Fazalul Rahiman

    2008-03-01

    Full Text Available The use of a personal computer together with a Data Acquisition System (DAQ as the processing tool in optical tomography systems has been the norm ever since the beginning of process tomography. However, advancements in silicon fabrication technology allow nowadays the fabrication of powerful Digital Signal Processors (DSP at a reasonable cost. This allows this technology to be used in an optical tomography system since data acquisition and processing can be performed within the DSP. Thus, the dependency on a personal computer and a DAQ to sample and process the external signals can be reduced or even eliminated. The DSP system was customized to control the data acquisition process of 16x16 optical sensor array, arranged in parallel beam projection. The data collected was used to reconstruct the cross sectional image of the pipeline conveyor. For image display purposes, the reconstructed image was sent to a personal computer via serial communication. This allows the use of a laptop to display the tomogram image besides performing any other offline analysis.

  3. FireSignal-Data acquisition and control system software

    International Nuclear Information System (INIS)

    Control of fusion experiments requires non-ambiguous, easy to use, user-interfaces to configure hardware devices. With that aim, a highly generic system for data control and acquisition has been developed. Among the main features it allows remote hardware configuration, shot launching, data sharing between connected users and experiment monitoring. The system is fully distributed: the hardware driver nodes, clients and servers are completely independent from each other and might run in different operating systems and programmed in different languages. All the communication is provided through the Common Object Request Broker Architecture (CORBA) protocol. FireSignal is designed to be as independent as possible from any kind of constraints as it is a plugin based system. Database, data viewers and the security system are some examples of what can easily be changed and adapted to the target machine's needs. In this system, every hardware is described in eXtensible Markup Language (XML) and with this information Graphical User Interfaces (GUI) are automatically built and user's parameter configuration validated. Any type of hardware device can be integrated in the system as long as it is described in XML and the respective driver developed. Any modern programming language can be used to develop these drivers. Currently Python and Java generic drivers are used. Data storage and indexing is time stamp event-based. Nodes are responsible for tagging the acquired samples with the absolute time stamps and to react to machine events. FireSignal is currently being used to control the ISTTOK/PT and CASTOR/CZ tokamaks

  4. Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems

    CERN Document Server

    Thiriet, Marc

    2013-01-01

    The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors.  Activation of...

  5. Energy Signal Tool for Decision Support in Building Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Henze, G. P.; Pavlak, G. S.; Florita, A. R.; Dodier, R. H.; Hirsch, A. I.

    2014-12-01

    A prototype energy signal tool is demonstrated for operational whole-building and system-level energy use evaluation. The purpose of the tool is to give a summary of building energy use which allows a building operator to quickly distinguish normal and abnormal energy use. Toward that end, energy use status is displayed as a traffic light, which is a visual metaphor for energy use that is either substantially different from expected (red and yellow lights) or approximately the same as expected (green light). Which light to display for a given energy end use is determined by comparing expected to actual energy use. As expected, energy use is necessarily uncertain; we cannot choose the appropriate light with certainty. Instead, the energy signal tool chooses the light by minimizing the expected cost of displaying the wrong light. The expected energy use is represented by a probability distribution. Energy use is modeled by a low-order lumped parameter model. Uncertainty in energy use is quantified by a Monte Carlo exploration of the influence of model parameters on energy use. Distributions over model parameters are updated over time via Bayes' theorem. The simulation study was devised to assess whole-building energy signal accuracy in the presence of uncertainty and faults at the submetered level, which may lead to tradeoffs at the whole-building level that are not detectable without submetering.

  6. 2012 Proceedings of the International Conference on Communications, Signal Processing, and Systems

    CERN Document Server

    Wang, Wei; Mu, Jiasong; Liang, Jing; Zhang, Baoju; Pi, Yiming; Zhao, Chenglin

    2012-01-01

    Communications, Signal Processing, and Systems is a collection of contributions coming out of the International Conference on Communications, Signal Processing, and Systems (CSPS) held October 2012. This book provides the state-of-art developments of Communications, Signal Processing, and Systems, and their interactions in multidisciplinary fields, such as Smart Grid. The book also examines Radar Systems, Sensor Networks, Radar Signal Processing, Design and Implementation of Signal Processing Systems and Applications. Written by experts and students in the fields of Communications, Signal Processing, and Systems.

  7. A portable monitor system for biology signal based on singlechip

    Science.gov (United States)

    Tu, Qiaoling; Guo, Jianhua; He, Li; Xu, Xia

    2005-12-01

    The objectives of the paper are to improve accuracy of the electrocardiogram and temperature signal, improve the system stability and the capability of dynamic response, and decrease power consumption and volume of the system. The basic method is making use of the inner resource of the singlechip, such as the exact constant-current source, hardware multiplier, ADC, etc. The model of singlechip is MSP430F449 of TI (Texas Instruments). A simple integral-coefficient band-rejection digital filter was designed for analyzing the electrocardiogram signal. The deviation of temperature coming from the degradation of battery voltage was compensated for. An automatic discharge access was designed in the circuit to improve the capability of dynamic response of circuit. The results indicate that the 50 Hz power frequency interfering and the baseline drift are filtered, the figure is clear, the accuracy of temperature is 0.03°C, and the consumption current is less than 1.3mA. The system can meet the requirement in ward monitor and surgery monitor.

  8. Chemotaxis signaling systems in model beneficial plant-bacteria associations.

    Science.gov (United States)

    Scharf, Birgit E; Hynes, Michael F; Alexandre, Gladys M

    2016-04-01

    Beneficial plant-microbe associations play critical roles in plant health. Bacterial chemotaxis provides a competitive advantage to motile flagellated bacteria in colonization of plant root surfaces, which is a prerequisite for the establishment of beneficial associations. Chemotaxis signaling enables motile soil bacteria to sense and respond to gradients of chemical compounds released by plant roots. This process allows bacteria to actively swim towards plant roots and is thus critical for competitive root surface colonization. The complete genome sequences of several plant-associated bacterial species indicate the presence of multiple chemotaxis systems and a large number of chemoreceptors. Further, most soil bacteria are motile and capable of chemotaxis, and chemotaxis-encoding genes are enriched in the bacteria found in the rhizosphere compared to the bulk soil. This review compares the architecture and diversity of chemotaxis signaling systems in model beneficial plant-associated bacteria and discusses their relevance to the rhizosphere lifestyle. While it is unclear how controlling chemotaxis via multiple parallel chemotaxis systems provides a competitive advantage to certain bacterial species, the presence of a larger number of chemoreceptors is likely to contribute to the ability of motile bacteria to survive in the soil and to compete for root surface colonization. PMID:26797793

  9. Signal and reference wave dually encrypted digital holographic system

    Institute of Scientific and Technical Information of China (English)

    ZHU YiChao; ZHANG JiaSen; GONG QiHuang

    2008-01-01

    We propose a secure digital holographic system with signal and reference waves dually encrypted. Two random phase masks are used to encrypt the images in the input and the Fourier planes. The reference beam is phase encoded by another random phase mask. The encrypted image and the key are recorded by a CCD camera. The data can be processed or transferred directly by computer. We theoretically and experimentally demonstrate encryption and decryption of multiple images and the results show a high quality and good fault tolerance.

  10. Fault Tolerant Neural Network for ECG Signal Classification Systems

    Directory of Open Access Journals (Sweden)

    MERAH, M.

    2011-08-01

    Full Text Available The aim of this paper is to apply a new robust hardware Artificial Neural Network (ANN for ECG classification systems. This ANN includes a penalization criterion which makes the performances in terms of robustness. Specifically, in this method, the ANN weights are normalized using the auto-prune method. Simulations performed on the MIT ? BIH ECG signals, have shown that significant robustness improvements are obtained regarding potential hardware artificial neuron failures. Moreover, we show that the proposed design achieves better generalization performances, compared to the standard back-propagation algorithm.

  11. Population Blocks.

    Science.gov (United States)

    Smith, Martin H.

    1992-01-01

    Describes an educational game called "Population Blocks" that is designed to illustrate the concept of exponential growth of the human population and some potential effects of overpopulation. The game material consists of wooden blocks; 18 blocks are painted green (representing land), 7 are painted blue (representing water); and the remaining…

  12. Cervical sympathetic block regulates early systemic inflammatory response in severe trauma patients

    OpenAIRE

    Liu, Ming-Hua; Tian, Jun; Su, Yong-Ping; WANG, Tao; Xiang, Qiang; Wen, Liang

    2013-01-01

    Background This aim of this study was to investigate the effects of one-side cervical sympathetic block on early inflammatory response in severe trauma patients. Material/Methods Thirty severe trauma patients with injury severity score (ISS) of 16 to 25 were randomly divided into treatment and control groups (n=15 each). Patients in the treatment group underwent a right-side stellate ganglion block (SGB) using 8 mL 0.75% ropivacaine for 4 times, with the first injection within 12 hr of admiss...

  13. Blocked strainers

    International Nuclear Information System (INIS)

    Thermal insulation was the cause of the blockages that shut down five BWRs in Sweden. The main culprit was mineral wool installed when the plants started up. Physical degradation of the wool over the lifetime of the plant meant it could easily be washed out of place during a loss of coolant accident and could quickly block strainers in the emergency core cooling systems. The five BWRs are almost all back on line, equipped with larger strainers and faster backwashing capability. But the incident prompted more detailed investigation into how materials in the containment would behave during an accident. One material that caused particular concern is Caposil, a material often used to insulate the reactor vessel. Composed of natural calcium, aluminium silicates and cellulose fibres, in the event of a LOCA Caposil becomes particularly hazardous. Under high pressure, or when brought into contact with high pressure water and steam, Caposil fragments into 1 cm clumps, free fibres, and ''fines''. It is these fines which cause major problems and can block a strainer extremely quickly. The successful testing of a high performance water filter which can handle Caposil is described. (4 figures) (Author)

  14. The Bucket System – A computer mediated signaling system for group improvisation

    DEFF Research Database (Denmark)

    Dahlstedt, Palle; Nilsson, Per Anders; Robair, Gino

    2015-01-01

    The Bucket System is a new system for computer-mediated ensemble improvisation, designed by improvisers for improvisers. Coming from a tradition of structured free ensemble improvisation practices (comprovisation), influenced by post-WW2 experimental music practices, it is a signaling system...

  15. Method for analyzing signaling networks in complex cellular systems.

    Science.gov (United States)

    Plavec, Ivan; Sirenko, Oksana; Privat, Sylvie; Wang, Yuker; Dajee, Maya; Melrose, Jennifer; Nakao, Brian; Hytopoulos, Evangelos; Berg, Ellen L; Butcher, Eugene C

    2004-02-01

    Now that the human genome has been sequenced, the challenge of assigning function to human genes has become acute. Existing approaches using microarrays or proteomics frequently generate very large volumes of data not directly related to biological function, making interpretation difficult. Here, we describe a technique for integrative systems biology in which: (i) primary cells are cultured under biologically meaningful conditions; (ii) a limited number of biologically meaningful readouts are measured; and (iii) the results obtained under several different conditions are combined for analysis. Studies of human endothelial cells overexpressing different signaling molecules under multiple inflammatory conditions show that this system can capture a remarkable range of functions by a relatively small number of simple measurements. In particular, measurement of seven different protein levels by ELISA under four different conditions is capable of reconstructing pathway associations of 25 different proteins representing four known signaling pathways, implicating additional participants in the NF-kappaBorRAS/mitogen-activated protein kinase pathways and defining additional interactions between these pathways. PMID:14745015

  16. The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells

    International Nuclear Information System (INIS)

    Accumulating evidence indicates that elevated levels of prostaglandin E2 (PGE2) can increase intestinal epithelial cell proliferation, and thus play a role in colorectal tumorigenesis. PGE2 exerts its effects through four G-protein-coupled PGE receptor (EP) subtypes, named the EP1, EP2, EP3, and EP4. Increased phosphorylation of extracellular regulated kinases (ERK1/2) is required for PGE2 to stimulate cell proliferation of human colon cancer cells. However, the EP receptor(s) that are involved in this process remain unknown. We provide evidence that L-161,982, a selective EP4 receptor antagonist, completely blocks PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. In order to identify downstream target genes of ERK1/2 signaling, we found that PGE2 induces expression of early growth response gene-1 (EGR-1) downstream of ERK1/2 and regulates its expression at the level of transcription. PGE2 treatment induces phosphorylation of cyclic AMP response element binding protein (CREB) at Ser133 residue and CRE-mediated luciferase activity in HCA-7 cells. Studies with dominant-negative CREB mutant (ACREB) provide clear evidence for the involvement of CREB in PGE2 driven egr-1 transcription in HCA-7 cells. In conclusion, this study reveals that egr-1 is a target gene of PGE2 in HCA-7 cells and is regulated via the newly identified EP4/ERK/CREB pathway. Finally our results support the notion that antagonizing EP4 receptors may provide a novel therapeutic approach to the treatment of colon cancer

  17. Fluorescence-enhancement with different ionic inputs in a cryptand-based multi-receptor signalling system

    Indian Academy of Sciences (India)

    Bamaprasad Bag; Parimal K Bharadwaj

    2005-03-01

    Two molecules of a laterally non-symmetric aza cryptand have been attached to 9,10-dimethylanthracene to obtain a multi-receptor fluorescent signalling system in the ``receptor-spacer-fluorophore- spacer-receptor” format. In the absence of a metal ion, weak fluorescence is observed upon excitation of the anthryl group owing to efficient photo-induced electron transfer (PET) of the lone pair of N attached to the anthryl group. However, when a metal salt is added, the lone pair is engaged, thus in blocking of the PET and leading to recovery of fluorescence to different extents depending upon the nature of the metal ion.

  18. Improper Gaussian Signaling in Interference-Limited Systems

    KAUST Repository

    Gaafar, Mohamed

    2016-05-01

    In the last decade, wireless applications have witnessed a tremendous growth. This can be envisioned in the surge of smart devices which became almost in everyone\\'s possession, demand for high speed connection and the internet of things (IoT) along with its enabling technologies. Hence, the multiuser interference became the main limiting factor in wireless communications. Moreover, just like diamonds and emeralds, the electromagnetic spectrum is limited and precious. Therefore, the high data rate application may not be satisfied by our current technologies. In order to solve this spectrum scarcity problem, researchers have steered their focus to develop new techniques such as cognitive radio (CR) and in-band full-duplex (FD). However, these systems suffer from the interference problem that can dramatically impede their quality-of-service (QoS). Therefore, investigating communication techniques/systems that can relieve the interference adverse signature becomes imperative. Improper Gaussian signaling (IGS) has been recently shown to outperform the traditional proper Gaussian signaling (PGS) in several interference-limited systems. In this thesis, we use IGS in order to mitigate the interference issue in three different communication settings. IGS has the ability to control the interference signal dimension, and hence, it can be considered as one form of interference alignment. In the first part, we investigate an underlay CR system with in-band FD primary users (PUs) and one-way communication for the secondary user (SU). IGS is employed to alleviate the interference introduced by the SU on the PUs. First, we derive a closed form expression and an upper bound for the SU and PUs outage probabilities, respectively. Second, we optimize the SU signal parameters, represented in its power and the circularity coefficient, to achieve the design objectives of the SU while satisfying certain QoS constraints for the PU under instantaneous, average and partial channel state

  19. GENERALIZED (COMPOSITE) SPACE VECTOR FOR A FLAT THREE-PHASE LINEARLY INDEPENDENT SYSTEM OF SIGNALS

    OpenAIRE

    Fedorenko, A.; Lazovskiy, Ed

    2011-01-01

    In the article the authors specify concept of composite vector for flat three-phase system of signals and give relators connecting instantaneous data of phase signals to coordinates of generalized vector in 3-D rectangular and cylindrical coordinate system.

  20. Special Issue on Signal Processing for Mechanical Systems in Honor of Professor Simon Braun

    Science.gov (United States)

    Fassois, Spilios D.

    2016-06-01

    This Special Issue is in honor of a pioneer of the area of Signal Processing for Mechanical Systems and, at the same time, Founding Editor of the Journal of Mechanical Systems and Signal Processing (MSSP), Professor Simon Braun.

  1. Analysis of the blocking behaviour of schema transformations in relational database systems

    NARCIS (Netherlands)

    Wevers, Lesley; Hofstra, Matthijs; Tammens, Menno; Huisman, Marieke; Keulen, van Maurice

    2015-01-01

    In earlier work we have extended the TPC-C benchmark with basic and complex schema transformations. This paper uses this benchmark to investigate the blocking behaviour of online schema transformations in PostgreSQL, MySQL and Oracle 11g. First we discuss experiments using the data definition langua

  2. Light relations and performance of signal grass in silvopastoral system

    Directory of Open Access Journals (Sweden)

    Cynara Oliveira Diniz Rodrigues

    2014-03-01

    Full Text Available The aim was to evaluate the influence of different spatial arrangements of trees [(3×2×20 m, (2×2×9 m and 2×9 m] and sampling sites (center of row spacing and side of tree rows with regard to the amount and quality of light in the understory of silvopastoral systems and their effects on the production and chemical composition of pasture. The experimental design was a randomized block in a split plot, with three replications. The sampling site affected absolute irradiance, photosynthetic active radiation (PAR, light interception (LI and red/far red ratio, with higher rates in the center of spacing. There were high and positive correlations between LI/leaf area index (LAI, LI/dry mater (DM and LAI/DM in the center and LI/LAI and FAR/DM in the side of tree rows. Spatial arrangement (3×2×20 m had higher rates for plant height (PH, DM and neutral detergent fiber rate, while (2×2×9 m had high leaf/stem ratio and crude protein rate. In the case of the sampling site, higher rates of PH and DM were reported in the center. Forage composition was not affected by sampling sites. Highest production of DM was obtained in the (3×2×20 m arrangement and improvements in forage composition were observed in denser arrangements.

  3. Quantifying process heterogeneity: Signal propagation in hydrological systems

    Science.gov (United States)

    Lischeid, G.; Merz, C.; Schindler, U.; Schulz, R.; Steidl, J.; Tauschke, R.

    2009-04-01

    Natural hydrological systems are characterized by heterogeneous structures. The typical length scale of the relevant structures is smaller than the resolution of area-covering methods that are available at the catchment-scale. On the other hand these structures are too large to be treated as random effects and are often related to hydrological behaviour in a non-linear way. Consequently, model results, risk assessments etc. are prone to substantial uncertainties. This is often addressed by random realizations of the structures based on given probability density functions and geostatistical properties, and then analysing the resulting effects on hydrological behaviour, e.g., discharge or groundwater table fluctuations, using process-based models. In this study an alternative approach was followed. Hydrological systems usually act as low-pass filters: An input signal (precipitation, groundwater recharge, tracer application, etc.) is damped and delayed during its passage through the system. This study aimed at characterizing the damping behaviour in a quantitative way. Large perturbations usually are transmitted at much higher velocities compared to small perturbations, thus hindering a spectrum analysis based approach. Instead, time series of soil water content, groundwater level and catchment runoff from the Uckermark region in North Germany were analysed using a principal component analysis. In all cases, the first component depicted the mean behaviour, and the second component explained a large fraction of the deviations from the mean behaviour. The loadings of the first two components could be used as an index of the mean damping behaviour for the given time period. Results of the soil water content data showed a linear increase of damping with depth at most sites. However, different sites differed substantially even for backfilled lysimeters that were considered to be homogeneous. There was no clear relationship between clay content and damping behaviour. The

  4. Playback of beyond high definition video signal in holographic data storage system with wavefront compensation and parallel signal processing

    Science.gov (United States)

    Muroi, Tetsuhiko; Kinoshita, Nobuhiro; Ishii, Norihiko; Kamijo, Koji; Kikuchi, Hiroshi

    2014-09-01

    We have developed a holographic data storage system that can demonstrate real-time playback of beyond high definition video signals. In the proposed system, to increase the data-transfer rate of the reproduced data, we focused on improving the SNR of the reproduced data and on improving the signal processing speed, which the SNR of the reproduced data has a significant effect on. One of the factors that deteriorate the SNR is shrinkage in the medium. This shrinkage distorts recorded holograms and degrades the quality of the reproduced data. We investigated wavefront compensation as a means to improve the SNR of reproduced data degraded by hologram distortion and found that controlling the defocus component of the reference beam is effective. We have also been developing parallel signal processing to increase the data-transfer rate. We placed three GPUs in the signal processing unit: one for the reproduced data detection from the reconstructed image and two for the LDPC decoding for error correction of the reproduced data. The LDPC decoding required a lot more time than the data detection, so we designed a signal processing in which detected data in the GPU for the data detection were sent to the two GPUs for the LDPC decoding alternatively. We implemented wavefront compensation for the defocus component and developed parallel signal processing with three GPUs for our holographic data storage system. Using this system, we demonstrated real-time playback of beyond high definition video signals with 50 Mbps.

  5. Begging the Signalling Question: Quantum Signalling and the Dynamics of Multiparticle Systems

    OpenAIRE

    Peacock, Kent A.; Hepburn, Brian S.

    1999-01-01

    Many authors state that quantum nonlocality could not involve any controllable superluminal transmission of momentum-energy, signals, or information. We claim that most or all no-signalling proofs to date are question-begging, in that they depend upon assumptions about the locality of the measurement process that needed to be established in the first place. We analyse no-signalling arguments by Bohm and Hiley, and Shimony, which illustrate the problem in an especially striking way.

  6. Begging the Signalling Question Quantum Signalling and the Dynamics of Multiparticle Systems

    CERN Document Server

    Peacock, K A; Peacock, Kent A.; Hepburn, Brian S.

    1999-01-01

    Many authors state that quantum nonlocality could not involve any controllable superluminal transmission of momentum-energy, signals, or information. We claim that most or all no-signalling proofs to date are question-begging, in that they depend upon assumptions about the locality of the measurement process that needed to be established in the first place. We analyse no-signalling arguments by Bohm and Hiley, and Shimony, which illustrate the problem in an especially striking way.

  7. Verification of a pencil beam based treatment planning system: output factors for open photon beams shaped with MLC or blocks

    International Nuclear Information System (INIS)

    The accuracy of monitor unit calculations from a pencil beam based, three-dimensional treatment planning system (3D TPS) has been evaluated for open irregularly shaped photon fields. The dose per monitor unit was measured in water and in air for x-ray beam qualities from 6 to 15 MV. The fields were shaped either with a multileaf collimator (MLC) or with customized alloy blocks. Calculations from the 3D TPS were compared with measurements. The agreement between calculated and measured dose per monitor unit depended on field size and the amount of blocking and was within 3% for the MLC-shaped fields. The deviation could be traced to limitations in head scatter modelling for the MLC. For fields shaped with alloy blocks, the dose per monitor unit was calculated to be within 1.6% of measured values for all fields studied. The measured and calculated relative phantom scatter for fields with the same equivalent field size were identical for MLC and alloy shaped fields. These results indicate that the accuracy in the TPS calculations for open irregular fields, shaped with MLC or blocks, is satisfactory for clinical situations. (author)

  8. Adaptive Noise Cancellation Method Used for Wheel Speed Signal of Integrate ABS/ASR System

    Institute of Scientific and Technical Information of China (English)

    MA Yue-feng; LIU Zhao-du; QI Zhi-quan; CUI Hai-feng

    2006-01-01

    A novel adaptive noise cancellation method for wheel speed signal of the anti-lock braking system/anti-slip regulation(ABS/ASR) control system is proposed. Based on the spectrum distribution of vehicle's wheel speed signal got from fast Fourier transform under various conditions, the high-pass filter is used to deal with original wheel speed signals sampled to get reference noise signal and the original wheel speed signals are used as adaptive filter's desired outputs. The difference between original signals and reference noise signals is used as the error signal for the adaptive FIR filter and also used as the whole adaptive noise cancellation system's final output. This method can obtain the noise signal on-line and is easy to use for real control system,which is useful to improve the performance of integrate system ABS/ASR.

  9. Characteristic parameters of electromagnetic signals from a human heart system

    Science.gov (United States)

    Liu, Xin-Yuan; Pei, Liu-Qing; Wang, Yin; Zhang, Su-Ming; Gao, Hong-Lei; Dai, Yuan-Dong

    2011-04-01

    The electromagnetic field of a human heart system is a bioelectromagnetic field. Electrocardiography (ECG) and magnetocardiography (MCG) are both carriers of electromagnetic information about the cardiac system, and they are nonstationary signals. In this study, ECG and MCG data from healthy subjects are acquired; the MCG data are captured using a high-Tc radio frequency superconducting quantum interference device (HTc rf SQUIDs) and the QRS complexes in these data are analysed by the evolutionary spectrum analysis method. The results show that the quality factor Q and the central frequency fz of the QRS complex evolutionary spectrum are the characteristic parameters (CHPs) of ECG and MCG in the time—frequency domain. The confidence intervals of the mean values of the CHPs are estimated by the Student t distribution method in mathematical statistics. We believe that there are threshold ranges of the mean values of Q and fz for healthy subjects. We have postulated the following criterion: if the mean values of CHPs are in the proper ranges, the cardiac system is in a normal condition and it possesses the capability of homeostasis. In contrast, if the mean values of the CHPs do not lie in the proper ranges, the homeostasis of the cardiac system is lacking and some cardiac disease may follow. The results and procedure of MCG CHPs in the study afford a technological route for the application of HTc rf SQUIDs in cardiology.

  10. Random Telegraph Signal in a Metallic Double-Dot System

    Science.gov (United States)

    Vardi, Yuval; Guttman, Avraham; Bar-Joseph, Israel

    2015-03-01

    Double quantum dot systems offer a unique opportunity for studying the world of quantum transport. This stems from the ability to localize an electron in a limited region in space on the dot, and monitor its presence and properties. Another system, in which electrons can be stored and measured, is an electronic trap in solid. The electrons in such a trap are better isolated from the environment. However, their measurement and control are more difficult. Here we demonstrate how these two systems, metallic double-dots and electronic traps, are combined to yield a hybrid structure in which an electron can be stored for long durations and can be easily detected and measured. We investigate the dynamics of a single electron surface trap, embedded in a self-assembly metallic double-dot system. The charging and discharging of the trap by a single electron is manifested as a random telegraph signal of the current through the double-dot device. We find that we can control the duration that an electron resides in the trap through the current, varying it between fractions of a second to more than an hour, at the Coulomb blockade region. We suggest that the observed switching is the electrical manifestation of the optical blinking phenomenon, commonly observed in semiconductor quantum dots. Y. Vardi, A. Guttman, and I. Bar-Joseph, Nano Lett. 14, 2794 (2014). [DOI: 10.1021/nl500803p

  11. Characteristic parameters of electromagnetic signals from a human heart system

    International Nuclear Information System (INIS)

    The electromagnetic field of a human heart system is a bioelectromagnetic field. Electrocardiography (ECG) and magnetocardiography (MCG) are both carriers of electromagnetic information about the cardiac system, and they are nonstationary signals. In this study, ECG and MCG data from healthy subjects are acquired; the MCG data are captured using a high-Tc radio frequency superconducting quantum interference device (HTc rf SQUIDs) and the QRS complexes in these data are analysed by the evolutionary spectrum analysis method. The results show that the quality factor Q and the central frequency fz of the QRS complex evolutionary spectrum are the characteristic parameters (CHPs) of ECG and MCG in the time—frequency domain. The confidence intervals of the mean values of the CHPs are estimated by the Student t distribution method in mathematical statistics. We believe that there are threshold ranges of the mean values of Q and fz for healthy subjects. We have postulated the following criterion: if the mean values of CHPs are in the proper ranges, the cardiac system is in a normal condition and it possesses the capability of homeostasis. In contrast, if the mean values of the CHPs do not lie in the proper ranges, the homeostasis of the cardiac system is lacking and some cardiac disease may follow. The results and procedure of MCG CHPs in the study afford a technological route for the application of HTc rf SQUIDs in cardiology. (condensed matter: electronic structure, electrical, magnetic, and optical properties)

  12. Characteristic parameters of electromagnetic signals from a human heart system

    Institute of Scientific and Technical Information of China (English)

    Liu Xin-Yuan; Pei Liu-Qing; Wang Yin; Zhang Su-Ming; Gao Hong-Lei; Dai Yuan-Dong

    2011-01-01

    The electromagnetic field of a human heart system is a bioelectromagnetic field. Electrocardiography (ECG)and magnetocardiography (MCG)are both carriers of electromagnetic information about the cardiac system, and they are nonstationary signals. In this study, ECG and MCG data from healthy subjects are acquired;the MCG data are captured using a high-T, radio frequency superconducting quantum interference device (HTc rf SQUIDs)and the QRS complexes in these data are analysed by the evolutionary spectrum analysis method. The results show that the quality factor Q and the central frequency fz of the QRS complex evolutionary spectrum are the characteristic parameters (CHPs)of ECG and MCG in the time-frequency domain. The confidence intervals of the mean values of the CHPs are estimated by the Student t distribution method in mathematical statistics. We believe that there are threshold ranges of the mean values of Q and fz for healthy subjects. We have postulated the following criterion:if the mean values of CHPs are in the proper ranges, the cardiac system is in a normal condition and it possesses the capability of homeostasis. In contrast, if the mean values of the CHPs do not lie in the proper ranges, the homeostasis of the cardiac system is lacking and some cardiac disease may follow. The results and procedure of MCG CHPs in the study afford a technological route for the application of HTc rf SQUIDs in cardiology.

  13. Role of Wnt Signaling in Central Nervous System Injury.

    Science.gov (United States)

    Lambert, Catherine; Cisternas, Pedro; Inestrosa, Nibaldo C

    2016-05-01

    The central nervous system (CNS) is highly sensitive to external mechanical damage, presenting a limited capacity for regeneration explained in part by its inability to restore either damaged neurons or the synaptic network. The CNS may suffer different types of external injuries affecting its function and/or structure, including stroke, spinal cord injury, and traumatic brain injury. These pathologies critically affect the quality of life of a large number of patients worldwide and are often fatal because available therapeutics are ineffective and produce limited results. Common effects of the mentioned pathologies involves the triggering of several cellular and metabolic responses against injury, including infiltration of blood cells, inflammation, glial activation, and neuronal death. Although some of the underlying molecular mechanisms of those responses have been elucidated, the mechanisms driving these processes are poorly understood in the context of CNS injury. In the last few years, it has been suggested that the activation of the Wnt signaling pathway could be important in the regenerative response after CNS injury, activating diverse protective mechanisms including the stimulation of neurogenesis, blood brain structure consolidation and the recovery of cognitive brain functions. Because Wnt signaling is involved in several physiological processes, the putative positive role of its activation after injury could be the basis for novel therapeutic approaches to CNS injury. PMID:25976365

  14. Block Advertisement Protocol

    OpenAIRE

    Nemirovsky, Danil

    2015-01-01

    Bitcoin, a decentralized cryptocurrency, has attracted a lot of attention from academia, financial service industry and enthusiasts. The trade-off between transaction confirmation throughput and centralization of hash power do not allow Bitcoin to perform at the same level as modern payment systems. Block Advertisement Protocol is proposed as a step to resolve this issue. The protocol allows block mining and block relaying to happen in parallel. The protocol dictates a miner to advertise the ...

  15. HLA Class I and II Blocks Are Associated to Susceptibility, Clinical Subtypes and Autoantibodies in Mexican Systemic Sclerosis (SSc Patients.

    Directory of Open Access Journals (Sweden)

    Tatiana S Rodriguez-Reyna

    Full Text Available Human leukocyte antigen (HLA polymorphism studies in Systemic Sclerosis (SSc have yielded variable results. These studies need to consider the genetic admixture of the studied population. Here we used our previously reported definition of genetic admixture of Mexicans using HLA class I and II DNA blocks to map genetic susceptibility to develop SSc and its complications.We included 159 patients from a cohort of Mexican Mestizo SSc patients. We performed clinical evaluation, obtained SSc-associated antibodies, and determined HLA class I and class II alleles using sequence-based, high-resolution techniques to evaluate the contribution of these genes to SSc susceptibility, their correlation with the clinical and autoantibody profile and the prevalence of Amerindian, Caucasian and African alleles, blocks and haplotypes in this population.Our study revealed that class I block HLA-C*12:03-B*18:01 was important to map susceptibility to diffuse cutaneous (dc SSc, HLA-C*07:01-B*08:01 block to map the susceptibility role of HLA-B*08:01 to develop SSc, and the C*07:02-B*39:05 and C*07:02-B*39:06 blocks to map the protective role of C*07:02 in SSc. We also confirmed previous associations of HLA-DRB1*11:04 and -DRB1*01 to susceptibility to develop SSc. Importantly, we mapped the protective role of DQB1*03:01 using three Amerindian blocks. We also found a significant association for the presence of anti-Topoisomerase I antibody with HLA-DQB1*04:02, present in an Amerindian block (DRB1*08:02-DQB1*04:02, and we found several alleles associated to internal organ damage. The admixture estimations revealed a lower proportion of the Amerindian genetic component among SSc patients.This is the first report of the diversity of HLA class I and II alleles and haplotypes Mexican patients with SSc. Our findings suggest that HLA class I and class II genes contribute to the protection and susceptibility to develop SSc and its different clinical presentations as well as

  16. Statistical Signal Processing in Humanitarian Mine Clerance Systems

    DEFF Research Database (Denmark)

    Karlsen, Brian; Sørensen, Helge Bjarup Dissing; Larsen, Jan;

    2002-01-01

    Denne artikel beskriver kortfattet metoder og resultater relateret til clutterreduktion (clutter: uønskede reflekterede signaler) i jordradar- (eng. ground penetrating radar, GPR) signaler vha. statistiske signalbehandlingsmetoder baseret på Independent Component Analysis (ICA). Formålet ved denne...... form for clutterreduktion er at dekomponere GPR signaler i clutter og clutterreducerede underrum. Ved kun at anvende de clutterreducerede underrum kan man reducere clutter i GPR signaler. Metoderne giver gode resultater ved detektering af landminer....

  17. Chaotic signal reconstruction with application to noise radar system

    OpenAIRE

    Liu Lidong; Hu Jinfeng; He Zishu; Han Chunlin; Li Huiyong; Li Jun

    2011-01-01

    Abstract Chaotic signals are potentially attractive in engineering applications, most of which require an accurate estimation of the actual chaotic signal from a noisy background. In this article, we present an improved symbolic dynamics-based method (ISDM) for accurate estimating the initial condition of chaotic signal corrupted by noise. Then, a new method, called piecewise estimation method (PEM), for chaotic signal reconstruction based on ISDM is proposed. The reconstruction performance u...

  18. Development of DC-TOP Signal Processing System

    Energy Technology Data Exchange (ETDEWEB)

    Nam, Uk Won [Korea Astronomy and Space Science Institute, Daejeon (Korea, Republic of)

    2010-08-15

    The PSD panel of the DC-TOF consists of 32 PSD(Position Sensitive Detector) and its signal processing part. Each signal processing part can communicate with Data Acquisition PC with TCP/IP protocol. By such a way, total 352 PSD(l1 paneD can be used in DC-TOF. In panel, 1 DSP, 8 PML and 64 PAM are installed as signal processing part, and control neutron detecting signal from 32 PSDs

  19. Statistical Signal Processing in Humanitarian Mine Clerance Systems

    OpenAIRE

    Karlsen, Brian; Sørensen, Helge Bjarup Dissing; Larsen, Jan; Jakobsen, Kaj Bjarne

    2002-01-01

    Denne artikel beskriver kortfattet metoder og resultater relateret til clutterreduktion (clutter: uønskede reflekterede signaler) i jordradar- (eng. ground penetrating radar, GPR) signaler vha. statistiske signalbehandlingsmetoder baseret på Independent Component Analysis (ICA). Formålet ved denne form for clutterreduktion er at dekomponere GPR signaler i clutter og clutterreducerede underrum. Ved kun at anvende de clutterreducerede underrum kan man reducere clutter i GPR signaler. Metoderne ...

  20. Unlocking Chain Exchange in Highly Amphiphilic Block Polymer Micellar Systems: Influence of Agitation

    OpenAIRE

    Murphy, Ryan P.; Kelley, Elizabeth G.; Rogers, Simon A.; Sullivan, Millicent O.; Epps, Thomas H.

    2014-01-01

    Chain exchange between block polymer micelles in highly selective solvents, such as water, is well-known to be arrested under quiescent conditions, yet this work demonstrates that simple agitation methods can induce rapid chain exchange in these solvents. Aqueous solutions containing either pure poly(butadiene-b-ethylene oxide) or pure poly(butadiene-b-ethylene oxide-d 4) micelles were combined and then subjected to agitation by vortex mixing, concentric cylinder Couette flow, or nitrogen gas...

  1. Hepatic venous outflow block in a young patient with Systemic Lupus Erythematosus

    OpenAIRE

    Ali Ghavidel

    2015-01-01

    Introduction: Hepatic venous outflow block or Budd-Chiari syndrome is a severe liver disease with a 3 years survival rate of 50%. Several conditions have been implicated as a cause of Budd-Chiari syndrome, including myeloproliferative disorders, paroxysmal nocturnal hemoglobinuria, the presence of lupus anti-coagulant, oral contraceptives, pregnancy, and others. In a small number of cases, Budd-Chiari syndrome is associated with the presence of lupus anticoagulant. Anticardiolipin antibodies ...

  2. Permutation-based Homogeneous Block Content Authentication for Watermarking

    Directory of Open Access Journals (Sweden)

    S.Maruthuperumal

    2013-02-01

    Full Text Available In modern days, digital watermarking has become an admired technique for hitting data in digital images to help guard against copyright infringement. The proposed Permutation-based Homogeneous Block Content authentication (PHBC methods develop a secure and excellence strong watermarking algorithm that combines the reward of permutation-based Homogeneous block (PHB with that of significant and insignificant bit values with X0R encryption function using Max coefficient of least coordinate value for embedding the watermark. In the projected system uses the relationship between the permutation blocks to embed many data into Homogeneous blocks without causing solemn distortion to the watermarked image. The experimental results show that the projected system is very efficient in achieving perceptual invisibility with an increase in the Peak Signal to Noise Ratio (PSNR. Moreover, the projected system is robust to a variety of signal processing operations, such as image Cropping, Rotation, Resizing, Adding noise, Filtering , Blurring and Motion blurring.

  3. The measurement of some signals for control system of 60Co scan system for freight train

    International Nuclear Information System (INIS)

    The 60Co Scan system for Freight Train has an automatic inspection flow, so it is very crucial that the measurement of the signals for the automatic control system. In this paper, we mainly introduce the identification of the intervals between two freight train carriage, the measurement of the train speed, and identification of freight train

  4. SIBYLLE: an expert system for the interpretation in real time of mono-dimensional signals; application to vocal signal

    International Nuclear Information System (INIS)

    This report presents an interactive tool for computer aided building of signals processing and interpretation systems. This tool includes three main parts: - an expert system, - a rule compiler, - a real time procedural system. The expert system allows the acquisition of knowledge about the signal. Knowledge has to be formalized as a set of rewriting rules (or syntaxical rules) and is introduced with an interactive interface. The compiler makes a compilation of the knowledge base (the set of rules) and generates a procedural system, which is equivalent to the expert system. The generated procedural system is a fixed one but is much faster than the expert system: it can work in real time. The expert system is used along the experimental phase on a small corpus of data: the knowledge base is then tested and possibly modified thanks to the interactive interface. Once the knowledge base is steady enough, the procedural system is generated and tested on a bigger data corpus. This allows to perform significant statistical studies which generally induce some corrections at the expert system level. The overall constitutes a tool which conciliates the expert systems flexibility with the procedural systems speed. It has been used for building a set of recognition rules modules on vocal signal - module of sound-silence detection - module of voiced-unvoiced segmentation - module of synchronous pitch detection. Its possibilities are not limited to the study of vocal signal, but can be enlarged to any mono-dimensional signal processing. A feasibility study has been realised for an electrocardiograms application. (author)

  5. Lesson Thirteen Trifascicular Block

    Institute of Scientific and Technical Information of China (English)

    鲁端; 王劲

    2005-01-01

    @@ A complete trifascicular block would result in complete AV block. The idio ventricular rhythm has a slower rate and a wide QRS complex because the pacemaker is located at the peripheral part of the conduction system distal to the sites of the block1. Such a rhythm may be difficult to differentiate from bifascicular or bundle branch block combined with complete block at a higher level such as the AV node or His bundle2. Besides a slower ventricular rate, a change in the morphology of the QRS complex from a previous known bifascicular pattern would be strongly suggestive of a trifascicular origin of the complete AV block3. A His bundle recording is required for a definitive diagnosis, however.

  6. SELF-ADAPTIVE CONTROLS OF A COMPLEX CELLULAR SIGNALING TRANSDUCTION SYSTEM

    Institute of Scientific and Technical Information of China (English)

    LI Hong; ZHOU Zhiyuan; DAI Rongyang; LUO Bo; ZHENG Xiaoli; YANG Wenli; HE Tao; WU Minglu

    2004-01-01

    In cells, the interactions of distinct signaling transduction pathways originating from cross-talkings between signaling molecules give rise to the formation of signaling transduction networks, which contributes to the changes (emergency) of kinetic behaviors of signaling system compared with single molecule or pathway. Depending on the known experimental data, we have constructed a model for complex cellular signaling transduction system, which is derived from signaling transduction of epidermal growth factor receptor in neuron. By the computational simulating methods, the self-adaptive controls of this system have been investigated. We find that this model exhibits a relatively stable selfadaptive system, especially to over-stimulation of agonist, and the amplitude and duration of signaling intermediates in it could be controlled by multiple self-adaptive effects, such as "signal scattering", "positive feedback", "negative feedback" and "B-Raf shunt". Our results provide an approach to understanding the dynamic behaviors of complex biological systems.

  7. Engineering satellite-based navigation and timing global navigation satellite systems, signals, and receivers

    CERN Document Server

    Betz, J

    2016-01-01

    This book describes the design and performance analysis of satnav systems, signals, and receivers. It also provides succinct descriptions and comparisons of all the world’s satnav systems. Its comprehensive and logical structure addresses all satnav signals and systems in operation and being developed. Engineering Satellite-Based Navigation and Timing: Global Navigation Satellite Systems, Signals, and Receivers provides the technical foundation for designing and analyzing satnav signals, systems, and receivers. Its contents and structure address all satnav systems and signals: legacy, modernized, and new. It combines qualitative information with detailed techniques and analyses, providing a comprehensive set of insights and engineering tools for this complex multidisciplinary field. Part I describes system and signal engineering including orbital mechanics and constellation design, signal design principles and underlying considerations, link budgets, qua tifying receiver performance in interference, and e...

  8. An interactive system for seismic signal detection and identification

    International Nuclear Information System (INIS)

    The methods to distinguish an underground explosion from an earthquake are mainly based on exploiting the differences in the source functions of the two processes and locating the depth of source. Various characteristics of seismic signals generated by these sources are usually represented by different parameters or identifiers. However, it is not possible for a single identifier to distinguish an explosion from an earthquake with equal effectiveness in all situations. Usually a combination of several identifiers is found to provide effective means for the identification of seismic sources. In order to use the multiple parameters in an optimum way, an interactive system (IS) for detection and identification of global events has been developed using short period data of Gauribidanur array. This report describes the salient features of the IS and demonstrates its effectiveness in identifying an event using weighted combination of the parameters together with the depth of source. It is intended to augment the system with long period data in the next phase of the development. (author). 37 refs., 14 figs., 2 tabs

  9. Digital Signal Processing Based Real Time Vehicular Detection System

    Institute of Scientific and Technical Information of China (English)

    YANG Zhaoxuan; LIN Tao; LI Xiangping; LIU Chunyi; GAO Jian

    2005-01-01

    Traffic monitoring is of major importance for enforcing traffic management policies.To accomplish this task,the detection of vehicle can be achieved by exploiting image analysis techniques.In this paper,a solution is presented to obtain various traffic parameters through vehicular video detection system(VVDS).VVDS exploits the algorithm based on virtual loops to detect moving vehicle in real time.This algorithm uses the background differencing method,and vehicles can be detected through luminance difference of pixels between background image and current image.Furthermore a novel technology named as spatio-temporal image sequences analysis is applied to background differencing to improve detection accuracy.Then a hardware implementation of a digital signal processing (DSP) based board is described in detail and the board can simultaneously process four-channel video from different cameras. The benefit of usage of DSP is that images of a roadway can be processed at frame rate due to DSP′s high performance.In the end,VVDS is tested on real-world scenes and experiment results show that the system is both fast and robust to the surveillance of transportation.

  10. Analysis on Design of Kohonen-network System Based on Classification of Complex Signals

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The key methods of detection and classification of the electroencephalogram(EEG) used in recent years are introduced . Taking EEG for example, the design plan of Kohonen neural network system based on detection and classification of complex signals is proposed, and both the network design and signal processing are analyzed, including pre-processing of signals, extraction of signal features, classification of signal and network topology, etc.

  11. Intelligent interfaces to expert systems illustrated by a programmable signal validation system

    International Nuclear Information System (INIS)

    This paper discusses a software tool for the development of effective interfaces to an expert system. These are interfaces to end-users, application developers, as well as interfaces to other software modules. The application of this tool is illustrated by discussing a programmable signal validation capability. The objective of this discussion is to demonstrate how easily an expert system application can be configured through the use of graphics to reflect changes in instrumentation, plant, especially nuclear power plant configuration or signal validation logic

  12. Reduction of Under-Determined Linear Systems by Sparce Block Matrix Technique

    DEFF Research Database (Denmark)

    Tarp-Johansen, Niels Jacob; Poulsen, Peter Noe; Damkilde, Lars

    1996-01-01

    -determined equilibrium equation restrictions in an LP-problem. A significant reduction of computer time spent on solving the LP-problem is achieved if the equilib rium equations are reduced before going into the optimization procedure. Experience has shown that for some structures one must apply full pivoting to ensure...... numerical stability of the aforementioned reduction. Moreover the coefficient matrix for the equilibrium equations is typically very sparse. The objective is to deal efficiently with the full pivoting reduction of sparse rectangular matrices using a dynamic storage scheme based on the block matrix concept....

  13. A signal processing method for the friction-based endpoint detection system of a CMP process

    Energy Technology Data Exchange (ETDEWEB)

    Xu Chi; Guo Dongming; Jin Zhuji; Kang Renke, E-mail: xuchi_dut@163.com [Key Laboratory for Precision and Non-Traditional Machining Technology of Ministry of Education, Dalian University of Technology, Dalian 116024 (China)

    2010-12-15

    A signal processing method for the friction-based endpoint detection system of a chemical mechanical polishing (CMP) process is presented. The signal process method uses the wavelet threshold denoising method to reduce the noise contained in the measured original signal, extracts the Kalman filter innovation from the denoised signal as the feature signal, and judges the CMP endpoint based on the feature of the Kalman filter innovation sequence during the CMP process. Applying the signal processing method, the endpoint detection experiments of the Cu CMP process were carried out. The results show that the signal processing method can judge the endpoint of the Cu CMP process. (semiconductor technology)

  14. Interleukin-7 Receptor Signaling Network: An Integrated Systems Perspective

    Institute of Scientific and Technical Information of China (English)

    Megan J. Palmer; Vinay S. Mahajan; Lily C. Trajman; Darrell J. Irvine; Douglas A.Lauffenburger; Jianzhu Chen

    2008-01-01

    Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor, the IL-7 receptor (IL-7R), activates multiple pathways that regulate lymphocyte survival, glucose uptake, proliferation and differentiation. There has been much interest in understanding how IL-7 receptor signaling is modulated at multiple interconnected network levels. This review examines how the strength of the signal through the IL-7 receptor is modulated in T and B cells, including the use of shared receptor components, signaling crosstaik, shared interaction domains, feedback loops, integrated gene regulation, muitimerization and ligand competition. We discuss how these network control mechanisms could integrate to govern the properties of IL-7R signaling in lymphocytes in health and disease. Analysis of IL-7receptor signaling at a network level in a systematic manner will allow for a comprehensive approach to understanding the impact of multiple signaling pathways on lymphocyte biology.

  15. Hardware System for Real-Time EMG Signal Acquisition and Separation Processing during Electrical Stimulation.

    Science.gov (United States)

    Hsueh, Ya-Hsin; Yin, Chieh; Chen, Yan-Hong

    2015-09-01

    The study aimed to develop a real-time electromyography (EMG) signal acquiring and processing device that can acquire signal during electrical stimulation. Since electrical stimulation output can affect EMG signal acquisition, to integrate the two elements into one system, EMG signal transmitting and processing method has to be modified. The whole system was designed in a user-friendly and flexible manner. For EMG signal processing, the system applied Altera Field Programmable Gate Array (FPGA) as the core to instantly process real-time hybrid EMG signal and output the isolated signal in a highly efficient way. The system used the power spectral density to evaluate the accuracy of signal processing, and the cross correlation showed that the delay of real-time processing was only 250 μs. PMID:26210898

  16. Dynamic Vibrotactile Signals for Forward Collision Avoidance Warning Systems

    OpenAIRE

    Meng, Fanxing; Gray, Rob; Ho, Cristy.; Ahtamad, Mujthaba; Spence, Charles

    2015-01-01

    Objective: Four experiments were conducted in order to assess the effectiveness of dynamic vibrotactile collision-warning signals in potentially enhancing safe driving. Background: Auditory neuroscience research has demonstrated that auditory signals that move toward a person are more salient than those that move away. If this looming effect were found to extend to the tactile modality, then it could be utilized in the context of in-car warning signal design. Method: The effectiveness of vari...

  17. Wireless Body Area Network in a Ubiquitous Healthcare System for Physiological Signal Monitoring and Health Consulting

    OpenAIRE

    Joonyoung Jung; Kiryong Ha; Jeonwoo Lee; Youngsung Kim; Daeyoung Kim

    2008-01-01

    We developed a ubiquitous healthcare system consisted of aphysiological signal devices, a mobile system, a device provider system, a healthcare service provider system, a physician system, and a healthcare personal system. In this system, wireless body area network (WBAN) such as ZigBee is used to communicate between physiological signal devices and the mobile system. WBAN device needs a specific function for ubiquitous healthcare application. We propose a scanning algorithm, dynamic discover...

  18. Reliability assessments of railway signaling systems: A comparison and evaluation of approaches

    OpenAIRE

    Tang, Lichao

    2015-01-01

    The railway signaling system is the key system to ensure the safe operation of railway traffic. It is therefore important to have a safe and reliable railway signaling system. The railway authority defines requirements that should be complied with. The technical safety report is a vital documentation for the demonstration of fulfillment of requirements to the railway authority. A literature review of the signaling system is presented first. It describes the different technologies used for ...

  19. Fast optical signals in the peripheral nervous system

    Science.gov (United States)

    Tong, Yunjie; Martin, Jeffrey M.; Sassaroli, Angelo; Clervil, Patricia R.; Bergethon, Peter R.; Fantini, Sergio

    2006-07-01

    We present a study of the near-infrared optical response to electrical stimulation of peripheral nerves. The sural nerve of six healthy subjects between the ages of 22 and 41 was stimulated with transcutaneous electrical pulses in a region located approximately 10 cm above the ankle. A two-wavelength (690 and 830 nm) tissue spectrometer was used to probe the same sural nerve below the ankle. We measured optical changes that peaked 60 to 160 ms after the electrical stimulus. On the basis of the strong wavelength dependence of these fast optical signals, we argue that their origin is mostly from absorption rather than scattering. From these absorption changes, we obtain oxy- and deoxy-hemoglobin concentration changes that describe a rapid hemodynamic response to electrical nerve activation. In five out of six subjects, this hemodynamic response is an increase in total (oxy+deoxy) hemoglobin concentration, consistent with a fast vasodilation. Our findings support the hypothesis that the peripheral nervous system undergoes neurovascular coupling, even though more data is needed to prove such hypothesis.

  20. Encryption and validation of multiple signals for optical identification systems

    International Nuclear Information System (INIS)

    Multifactor encryption-authentication technique reinforces optical security by allowing the simultaneous A N D-verification of more than one primary image. Instead of basing the identification on a unique signature or piece of information, our goal is to authenticate a given person, object, vehicle by the simultaneous recognition of several factors. Some of them are intrinsic to the person and object or vehicle under control. Other factors, act as keys of the authentication step. Such a system is proposed for situations such as the access control to restricted areas, where the demand of security is high. The multifactor identification method involves double random-phase encoding, fully phase-based encryption and a combined nonlinear joint transform correlator and a classical 4f-correlator for simultaneous recognition and authentication of multiple images. The encoded signal fulfils the general requirements of invisible content, extreme difficulty in counterfeiting and real-time automatic verification. Four reference double-phase encoded images are compared with the retrieved input images obtained in situ from the person or the vehicle whose authentication is wanted and from a database. A recognition step based on the correlation between the signatures and the stored references determines the authentication or rejection of the person and object under surveillance

  1. Chaotic signal reconstruction with application to noise radar system

    Science.gov (United States)

    Liu, Lidong; Hu, Jinfeng; He, Zishu; Han, Chunlin; Li, Huiyong; Li, Jun

    2011-12-01

    Chaotic signals are potentially attractive in engineering applications, most of which require an accurate estimation of the actual chaotic signal from a noisy background. In this article, we present an improved symbolic dynamics-based method (ISDM) for accurate estimating the initial condition of chaotic signal corrupted by noise. Then, a new method, called piecewise estimation method (PEM), for chaotic signal reconstruction based on ISDM is proposed. The reconstruction performance using PEM is much better than that using the existing initial condition estimation methods. Next, PEM is applied in a noncoherent reception noise radar scheme and an improved noncoherent reception scheme is given. The simulation results show that the improved noncoherent scheme has better correlation performance and range resolution especially at low signal-to-noise ratios (SNRs).

  2. Chaotic signal reconstruction with application to noise radar system

    Directory of Open Access Journals (Sweden)

    Liu Lidong

    2011-01-01

    Full Text Available Abstract Chaotic signals are potentially attractive in engineering applications, most of which require an accurate estimation of the actual chaotic signal from a noisy background. In this article, we present an improved symbolic dynamics-based method (ISDM for accurate estimating the initial condition of chaotic signal corrupted by noise. Then, a new method, called piecewise estimation method (PEM, for chaotic signal reconstruction based on ISDM is proposed. The reconstruction performance using PEM is much better than that using the existing initial condition estimation methods. Next, PEM is applied in a noncoherent reception noise radar scheme and an improved noncoherent reception scheme is given. The simulation results show that the improved noncoherent scheme has better correlation performance and range resolution especially at low signal-to-noise ratios (SNRs.

  3. Design Error Performance of Space-Frequency Block Coded OFDM Systems with Different Equalizers and For Different Modulation Schemes

    Directory of Open Access Journals (Sweden)

    Rijhun Tripathi

    2012-01-01

    Full Text Available —Multiple transmit and receive antennas can be used to form multiple-input multiple-output (MIMO channels to increase the capacity (by a factor of the minimum number of transmit and receive antennas and data rate. In this paper, the combination of MIMO technology and orthogonal frequency division multiplexing (OFDM systems is considered for wideband transmission to mitigate inter symbol interference and to enhance system capacity. It owns the advantages of both MIMO and OFDM. MIMO-OFDM system exploits the space and frequency diversity simultaneously to improve the performance of system. The coding is done across OFDM subcarriers rather than OFDM symbols. In this paper, the performance of Space-Frequency (SF block coding for MIMO-OFDM along with different equalizers is investigated. Bit Error Rate (BER analysis is presented using different equalizers and then optimum equalization method is suggested.

  4. Quantitative assessment of probability of failing safely for the safety instrumented system using reliability block diagram method

    International Nuclear Information System (INIS)

    Highlights: • Models of PFS for SIS were established by using the reliability block diagram. • The more accurate calculation of PFS for SIS can be acquired by using SL. • Degraded operation of complex SIS does not affect the availability of SIS. • The safe undetected failure is the largest contribution to the PFS of SIS. - Abstract: The spurious trip of safety instrumented system (SIS) brings great economic losses to production. How to ensure the safety instrumented system is reliable and available has been put on the schedule. But the existing models on spurious trip rate (STR) or probability of failing safely (PFS) are too simplified and not accurate, in-depth studies of availability to obtain more accurate PFS for SIS are required. Based on the analysis of factors that influence the PFS for the SIS, using reliability block diagram method (RBD), the quantitative study of PFS for the SIS is carried out, and gives some application examples. The results show that, the common cause failure will increase the PFS; degraded operation does not affect the availability of the SIS; if the equipment was tested and repaired one by one, the unavailability of the SIS can be ignored; the corresponding occurrence time of independent safe undetected failure should be the system lifecycle (SL) rather than the proof test interval and the independent safe undetected failure is the largest contribution to the PFS for the SIS

  5. TV Trouble-Shooting Manual. Volumes 3-4. Part 1: Block Diagram of Colour TV Receiver and Signal Flow. Student and Instructor's Manuals.

    Science.gov (United States)

    Mukai, Masaaki; Kobayashi, Ryozo

    These volumes are, respectively, the self-instructional student manual and the teacher manual that cover the first set of training topics in this course for television repair technicians. Both volumes contain the following two sections: (1) Functional Block Diagram of a Colour TV Receiver, including information on the video reproduction circuit,…

  6. Auxiliary signal processing system for a multiparameter radar

    Science.gov (United States)

    Chandrasekar, V.; Gray, G. R.; Caylor, I. J.

    1993-01-01

    The design of an auxiliary signal processor for a multiparameter radar is described with emphasis on low cost, quick development, and minimum disruption of radar operations. The processor is based around a low-cost digital signal processor card and personal computer controller. With the use of such a concept, an auxiliary processor was implemented for the NCAR CP-2 radar during a 1991 summer field campaign and allowed measurement of additional polarimetric parameters, namely, the differential phase and the copolar cross correlation. Sample data are presented from both the auxiliary and existing radar signal processors.

  7. Concord Housing Blocks

    OpenAIRE

    Kumaraswamy, Mohan

    2002-01-01

    One element of the CIVCAL project Web-based resources containing images, tables, texts and associated data on the construction of Concord type Housing Blocks. A high rise public housing project using prefabriction and advanced formwork systems. Both Harmony and Concord Blocks are designed on the basis of standard modular flats which permit the use of factory produced components and a construction sequence which makes extensive use of advanced formwork systems.

  8. Multi-Purpose Radio Signal Generation System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The MRSiG will be able to replace many of the expensive, highly specialized RF signal generators with cheaper generic boxes that can be customized as the...

  9. Vitamin D signaling and the differentiation of developing dopamine systems.

    Science.gov (United States)

    Pertile, Renata A N; Cui, Xiaoying; Eyles, Darryl W

    2016-10-01

    Vitamin D regulates multiple factors including those involved in the ontogeny of dopaminergic systems. It has been shown that in neonatal rats maternally deprived of vitamin D, dopamine (DA) turnover is decreased with associated reductions in one catabolic enzyme, catechol-o-methyl transferase (COMT). To directly examine this signaling relationship, in the present study we have over-expressed the vitamin D receptor (VDR) in neuroblastoma SH-SY5Y cells in order to examine the mechanisms by which the active vitamin D hormone, 1,25(OH)2D3, via its receptor VDR, affects DA production and turnover. Our results show that VDR overexpression increases DA neuron differentiation by increasing tyrosine hydroxylase expression, DA production and decreasing the expression of NEUROG2 a marker of immature DA neurons. In the VDR-overexpressing cells, 1,25(OH)2D3 further increased the levels of the DA-metabolites 3-MT and HVA and elevated COMT gene expression. Chromatin immunoprecipitation revealed that 1,25(OH)2D3 increased VDR binding in three regions of the COMT promoter, strongly suggesting direct regulation. In addition, 1,25(OH)2D3 treatment attenuated increased levels of MAOA, DRD2 and VMAT2 gene expression caused by the VDR-overexpression. Taken together, these results show VDR and 1,25(OH)2D3 are directly involved in regulating the expression of dopaminergic-associated genes and that this in vitro neuronal model is a useful tool for identifying the role of 1,25(OH)2D3 in DA neuronal development and maturation. PMID:27450565

  10. Method and system for photoconductive detector signal correction

    Energy Technology Data Exchange (ETDEWEB)

    Carangelo, R.M.; Hamblen, D.G.; Brouillette, C.R.

    1992-08-04

    A corrective factor is applied so as to remove anomalous features from the signal generated by a photoconductive detector, and to thereby render the output signal highly linear with respect to the energy of incident, time-varying radiation. The corrective factor may be applied through the use of either digital electronic data processing means or analog circuitry, or through a combination of those effects. 5 figs.

  11. Method and system for photoconductive detector signal correction

    Energy Technology Data Exchange (ETDEWEB)

    Carangelo, Robert M. (Glastonbury, CT); Hamblen, David G. (East Hampton, CT); Brouillette, Carl R. (West Hartford, CT)

    1992-08-04

    A corrective factor is applied so as to remove anomalous features from the signal generated by a photoconductive detector, and to thereby render the output signal highly linear with respect to the energy of incident, time-varying radiation. The corrective factor may be applied through the use of either digital electronic data processing means or analog circuitry, or through a combination of those effects.

  12. Perturbation Biology: inferring signaling networks in cellular systems

    OpenAIRE

    Molinelli, Evan J.; Korkut, Anil; Wang, Weiqing; Miller, Martin L; Gauthier, Nicholas P.; Jing, Xiaohong; Kaushik, Poorvi; He, Qin; Mills, Gordon; Solit, David B.; Pratilas, Christine A.; Weigt, Martin; Braunstein, Alfredo; Pagnani, Andrea; Zecchina, Riccardo

    2013-01-01

    Author Summary Drugs that target specific effects of signaling proteins are promising agents for treating cancer. One of the many obstacles facing optimal drug design is inadequate quantitative understanding of the coordinated interactions between signaling proteins. De novo model inference of network or pathway models refers to the algorithmic construction of mathematical predictive models from experimental data without dependence on prior knowledge. De novo inference is difficult because of...

  13. Generation of probe signal for feedback cancellation systems

    OpenAIRE

    Odelius, Johan

    2004-01-01

    A common problem of hearing aids is whistling caused by feedback from the loudspeaker back to the microphone. A method of reducing the negative effects, caused by the feedback, is called feedback cancellation. A variant of feedback cancellation uses a probe signal, which is applied to the speaker of the hearing aid and is used to continuously estimate the feedback. Oticon A/S has suggested a master's thesis with the purpose of designing and evaluating an algorithm generating a probe signal fo...

  14. Low Cost Em Signal Spectral Analysis with Two Element Time Modulated Array System by Multiple Signal Classification Algorithms

    Directory of Open Access Journals (Sweden)

    G. Balagurappa,

    2014-03-01

    Full Text Available Today homeland security is a big matter of concern. The present day wireless technology is available to anti-social elements, who are using this in several undesirable manners. By knowing the direction of the source of electromagnetic waves it becomes possible to locate such anti-social groups and take offensive action. In military applications also finding the direction of the signal source becomes very valuable information. The direction finding systems can achieve this goal. Conventional radio direction finding (RDF systems often use an array of two or more antennas and use either phase-comparison or amplitude-comparison of the received signals to determine direction of arrival information. In both of these techniques directional information is derived by processing array data at the receive signal frequency. In this project an alternative approach to direction finding using the concept of a time-switched array is proposed. The time-switched array system uses simple signal processing techniques to provide a directional main beam and pattern nulls at harmonic frequencies. To determine two dimensional angles is three elements, the system cost has been mostly minimised. we now consider the problem of using our low cost system to detect and estimate the direction of arrival of a desired signal in the presence of array antenna. The proposed scheme is cost effective technique in comparison with the existing schemes. MATLAB/GNU OCTAVE simulation tool will be used for simulation. The simulation results, applications, merits and demerits of proposed approach will be analyzed and will be documented.

  15. Signal processing system for parallel plate ionization chamber at test beam of BEPC II

    International Nuclear Information System (INIS)

    A signal processing system has been designed in order to read out the electrode signals of 2D parallel plate ionization chamber at test beam facility of BEPC II. The system mainly includes that charge sensitive pre-amplifier, main-amplifier, analog to digital convertor and personal computer. Digital signals were recorded and displayed real time in histograms using data acquirement program based on Linux operating system. This signal processing system can be operated easily and has lower electronic noise and stable performance. (authors)

  16. A portable system for acquiring and removing motion artefact from ECG signals

    Energy Technology Data Exchange (ETDEWEB)

    Griffiths, A; Das, A; Fernandes, B; Gaydecki, P [School of Electrical and Electronic Engineering, University of Manchester, PO Box 88, Manchester M60 1QD (United Kingdom)

    2007-07-15

    A novel electrocardiograph (ECG) signal acquisition and display system is under development. It is designed for patients ranging from the elderly to athletes. The signals are obtained from electrodes integrated into a vest, amplified, digitally processed and transmitted via Bluetooth to a PC with a Labview (registered) interface. Digital signal processing is performed to remove movement artefact and electromyographic (EMG) noise, which severely distorts signal morphology and complicates clinical diagnosis. Independent component analysis (ICA) is also used to improve the signal quality. The complete system will integrate the electronics into a single module which will be embedded in the ves000.

  17. Control of polarization signal distortion by frequency domain phase conjugation in optical fiber systems

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Optical frequency domain phase conjugation(FDPC) is based on phase conjuga-tion of spectrum of an input signal.It is equivalent to the phase conjugation and the time reversal of the temporal envelope of an input signal.The use of FDPC to con-trol polarization signal distortion in birefringent optical fiber systems is proposed.Evolution of polarization signals in the system using midway FDPC is analyzed theoretically and simulated numerically.It is shown that the distortion of polariza-tion signals can be controlled effectively by FDPC.The impairments due to disper-sion and nonlinear effects can be suppressed simultaneously.

  18. Control of polarization signal distortion by frequency domain phase conjusation in optical fiber systems

    Institute of Scientific and Technical Information of China (English)

    BU Yang; WANG XiangZhao

    2008-01-01

    Optical frequency domain phase conjugation (FDPC) is based on phase conjugation of spectrum of an input signal. It is equivalent to the phase conjugation and the time reversal of the temporal envelope of an input signal. The use of FDPC to con-trol polarization signal distortion in birefringent optical fiber systems is proposed. Evolution of polarization signals in the system using midway FDPC is analyzed theoretically and simulated numerically. It is shown that the distortion of polariza-tion signals can be controlled effectively by FDPC. The impairments due to disper-sion and nonlinear effects can be suppressed simultaneously.

  19. A Survey of the Effectiveness of a Signal In a Wireless Analog and Digital System

    OpenAIRE

    Lundholm, Rickard; Bashir, Zaid; Kurowski, Sven

    2015-01-01

    The aim of this paper is to study the different parts of a wireless system in order to better understand the signal properties and what key factors changes the signal during its transmission. Two transmitters were created, an FM transmitter that transmits analog data and an Arudino board programed to convert data to bits before its transmission. The acquired signals were then compared to the original signal noting how differently the data had changed. To understand the antennas contribution t...

  20. System and method for adaptively deskewing parallel data signals relative to a clock

    Science.gov (United States)

    Jenkins, Philip Nord; Cornett, Frank N.

    2011-10-04

    A system and method of reducing skew between a plurality of signals transmitted with a transmit clock is described. Skew is detected between the received transmit clock and each of received data signals. Delay is added to the clock or to one or more of the plurality of data signals to compensate for the detected skew. The delay added to each of the plurality of delayed signals is updated to adapt to changes in detected skew.

  1. Research on fission chamber signal simulation of wide-range nuclear instrument system

    International Nuclear Information System (INIS)

    To establish an input signal to debug a digital wide-range nuclear instrument system (NIS) prototype, the research of fission chamber signal simulation was covered in this paper, which was composed of the simulation study of a pulse signal and a fluctuating current with pulse pile-up, and the signal output of the simulation results. The research is the first step to design and develop the algorithm of wide-range NIS prototype. (authors)

  2. The Open System Interconnection as a building block in a health sciences information network.

    OpenAIRE

    Boss, R W

    1985-01-01

    The interconnection of integrated health sciences library systems with other health sciences computer systems to achieve information networks will require either custom linkages among specific devices or the adoption of standards that all systems support. The most appropriate standards appear to be those being developed under the Open System Interconnection (OSI) reference model, which specifies a set of rules and functions that computers must follow to exchange information. The protocols hav...

  3. LOLA SYSTEM: A code block for nodal PWR simulation. Part. I - Simula-3 Code

    International Nuclear Information System (INIS)

    Description of the theory and users manual of the SIMULA-3 code, which is part of the core calculation system by nodal theory in one group, called LOLA SYSTEM. SIMULA-3 is the main module of the system, it uses a modified nodal theory, with interface leakages equivalent to the diffusion theory. (Author) 4 refs

  4. Wearable data acquisition system of multimodal physiological signals for personal health care.

    Science.gov (United States)

    Annus, Paul; Samieipour, Ali; Rist, Marek; Ruiso, Indrek; Krivoshei, Andrei; Land, Raul; Parve, Toomas; Min, Mart

    2013-01-01

    The paper proposes a wearable multimodal data acquisition system for biological signals. The system enables logging of electrical bioimpedance signals from multiple electrodes, electrocardiographic signals (ECG), acceleration signals from multiple locations, and spirometric data from a moving object. Later it will be used to conduct field measurements for characterizing health of the object under investigation. Main goal is to acquire enough data for development, refinement, and simplification of signal processing algorithms. The system is center part of the new wearable compact data acquisition modules ZCardio. Those modules enable multichannel impedance spectroscopy by logging ECG signals and data from the spirometric sensor. Initial reference measurements were conducted. Alternatively, tests were performed using Plessey Semiconductors capacitive sensors. Acceleration signals are gathered. PMID:23739367

  5. Mobile measurement system of ECG signal in vehicle environment

    Science.gov (United States)

    Oh, Kwang-seok; Lee, Sang-Ryong; Lee, Choon-Young; Kim, Myun-Hee

    2005-12-01

    This paper proposed a new method to measure the ECG signal from the driver. The ECG signal is often measured in the room. But it is mixed with many kinds of noise when it is measured during the vehicle moving. Noise occupied most many parts as the experimental among them was classified. And one suitable filter for each noise was designed. It used ALE(Adaptive Line Enhancement) to remove the noise occurred to electromagnetic wave in vehicle. To remove the noise occurred to steering or vibration of vehicle, the paper used Wavelet transformation after ALE(preprocessing filter). To realize unconscious measurement, this research used the stainless steel(not the electrode) fixed at steering wheel and designed the adaptive filter without using reference signal.

  6. Ghost Block

    OpenAIRE

    Webb, Neil

    2011-01-01

    Filmed on the English south coast 'Ghost Block' depicts the uncanny and eerie atmosphere at the site of a WW2 coastal defence line. The concrete cubes were used as an anti-invasion blockade against potential landing forces. This protection line now slowly decaying and becoming enmeshed into the environment still acts as a defence to repel unwanted visitors. The area is a natural reserve to nesting birds that often lay eggs directly onto the beach surface. The blocks act as a final barrier ...

  7. Porous block nanofiber composite filters

    Energy Technology Data Exchange (ETDEWEB)

    Ginley, David S.; Curtis, Calvin J.; Miedaner, Alexander; Weiss, Alan J.; Paddock, Arnold

    2016-08-09

    Porous block nano-fiber composite (110), a filtration system (10) and methods of using the same are disclosed. An exemplary porous block nano-fiber composite (110) includes a porous block (100) having one or more pores (200). The porous block nano-fiber composite (110) also includes a plurality of inorganic nano-fibers (211) formed within at least one of the pores (200).

  8. Treatment of metastatic colorectal carcinomas by systemic inhibition of vascular endothelial growth factor signaling in mice

    Institute of Scientific and Technical Information of China (English)

    Volker Schmitz; Miroslaw Kornek; Tobias Hilbert; Christian Dzienisowicz; Esther Raskopf; Christian Rabe; Tilman Sauerbruch; Cheng Qian; Wolfgang H Caselmann

    2005-01-01

    AIM: Tumor angiogenesis has been shown to be promoted by vascular endothelial growth factor (VEGF) via stimulating endothelial cell proliferation, migration, and survival.Blockade of VEGF signaling by different means has been demonstrated to result in reduced tumor growth and suppression of tumor angiogenesis in distinct tumor entities.Here, we tested a recombinant adenovirus, AdsFlt1-3,that encodes an antagonistically acting fragment of the VEGF receptor 1 (Flt-1), for systemic antitumor effects in pre-established subcutaneous CRC tumors in mice.METHODS: Murine colorectal carcinoma cells (CT26) were inoculated subcutaneously into Balb/c mice forin vivo studies. Tumor size and survival were determined. 293cell line was used for propagation of the adenoviral vectors.Human lung cancer line 4549 and human umbilical vein endothelial cells were transfected forin vitro experiments.RESULTS: Infection of tumor cells with AdsFlt1-3 resulted in protein secretion into cell supernatant, demonstrating correct vector function. As expected, the secreted sFlt1-3 protein had no direct effect on CT26 tumor cell proliferation in vitro, but endothelial cell function was inhibited by about 46% as compared to the AdLacZ control in a tube formation assay. When AdsFlt1-3 (5×109 PFU/animal) was applied to tumor bearing mice, we found a tumor inhibition by 72% at d 12 after treatment initiation. In spite of these antitumoral effects, the survival time was not improved.According to reduced intratumoral microvessel density in AdsFlt1-3-treated mice, the antitumor mechanism can be attributed to angiostatic vector effects. We did not detect increased systemic VEGF levels after AdsFlt1-3 treatment and liver toxicity was low as judged by serum alanine aminotransferase determination.CONCLUSION: In this study we confirmed the value of a systemic administration of AdsFlt1-3 to block VEGF signaling as antitumor therapy in an experimental metastatic colorectal carcinoma model in mice.

  9. A Threats Blocking Plug-in for Open Source Learning Management Systems

    Science.gov (United States)

    Braga, Gianluca; Sterbini, Andrea; Temperini, Marco

    Web-based Learning Management Systems, as in the nature of web-applications, are subject to attacks delivered through Internet, mainly aiming at accessing restricted data for illegal use. Protection from these kinds of threats is studied in the area of web applications and has been steadily improving in the last years. Nonetheless, especially in the area of very popular and easy-to-install web applications, such as Content Managements Systems, Blogs, and open source Learning Management Systems, the usual way to protect an installed system is to wait that weaknesses in the system software are discovered, and "patches" or new system releases are made available for installation. And this can be necessary also in cases in which no new threat technique has been discovered, while just another part of the system software has been detected as "weak" to that type of attack. Here we give an account of the most usual "exploit" techniques, known to be available, and describe a prototype methodology to equip certain Learning Management Systems (namely the open source ones, in particular those based on PHP engines) with a more stable protection, making it unnecessary to patch, or reinstall, a system in a hurry, after that minor weaknesses have been unveiled. The plug-in for a system is supposed to filter the input, sent by the user through a browser, and to avoid execution of server activities on suspect data. We test the methodology on Moodle, by producing a suitable plug-in, and verifying its success at system run-time.

  10. An offset tone based gain stabilization technique for mixed-signal RF measurement systems

    Science.gov (United States)

    Joshi, Gopal; Motiwala, Paresh D.; Randale, G. D.; Singh, Pitamber; Agarwal, Vivek; Kumar, Girish

    2015-09-01

    This paper describes a gain stabilization technique for a RF signal measurement system. A sinusoidal signal of known amplitude, phase and close enough in frequency is added to the main, to be measured RF signal at the input of the analog section. The system stabilizes this offset tone in the digital domain, as it is sampled at the output of the analog section. This process generates a correction factor needed to stabilize the magnitude of the gain of the analog section for the main RF signal. With the help of a simple calibration procedure, the absolute amplitude of the main RF signal can be measured. The technique is especially suited for a system that processes signals around a single frequency, employs direct signal conversion into the digital domain, and processes subsequent steps in an FPGA. The inherent parallel signal processing in an FPGA-based implementation allows a real time stabilization of the gain. The effectiveness of the technique is derived from the fact, that the gain stabilization stamped to the main RF signal measurement branch requires only a few components in the system to be inherently stable. A test setup, along with experimental results is presented from the field of RF instrumentation for particle accelerators. Due to the availability of a phase synchronized RF reference signal in these systems, the measured phase difference between the main RF and the RF reference is also stabilized using this technique. A scheme of the signal processing is presented, where a moving average filter has been used to filter out not only the unwanted frequencies, but also to separate the main RF signal from the offset tone signal. This is achieved by a suitable choice of sampling and offset tone frequencies. The presented signal processing scheme is suitable to a variety of RF measurement applications.

  11. An offset tone based gain stabilization technique for mixed-signal RF measurement systems

    International Nuclear Information System (INIS)

    This paper describes a gain stabilization technique for a RF signal measurement system. A sinusoidal signal of known amplitude, phase and close enough in frequency is added to the main, to be measured RF signal at the input of the analog section. The system stabilizes this offset tone in the digital domain, as it is sampled at the output of the analog section. This process generates a correction factor needed to stabilize the magnitude of the gain of the analog section for the main RF signal. With the help of a simple calibration procedure, the absolute amplitude of the main RF signal can be measured. The technique is especially suited for a system that processes signals around a single frequency, employs direct signal conversion into the digital domain, and processes subsequent steps in an FPGA. The inherent parallel signal processing in an FPGA-based implementation allows a real time stabilization of the gain. The effectiveness of the technique is derived from the fact, that the gain stabilization stamped to the main RF signal measurement branch requires only a few components in the system to be inherently stable. A test setup, along with experimental results is presented from the field of RF instrumentation for particle accelerators. Due to the availability of a phase synchronized RF reference signal in these systems, the measured phase difference between the main RF and the RF reference is also stabilized using this technique. A scheme of the signal processing is presented, where a moving average filter has been used to filter out not only the unwanted frequencies, but also to separate the main RF signal from the offset tone signal. This is achieved by a suitable choice of sampling and offset tone frequencies. The presented signal processing scheme is suitable to a variety of RF measurement applications

  12. Nuclear spectrometry signal acquisition and processing system based on LabVIEW and C

    International Nuclear Information System (INIS)

    The process of designing nuclear spectrometry signal acquisition and processing system based on virtual instrument technology is showed in this article. For the deficiency of LabVIEW in big data analyzing and processing, a method is presented in which C programmer is inserted and applied in signal smoothing, peak searching and area of the peak calculating. A complete nuclear spectrometry signal acquisition, processing and document management system is implemented. (authors)

  13. Design and implementation of a hybrid circuit system for micro sensor signal processing*

    Institute of Scientific and Technical Information of China (English)

    Wang Zhuping; Chen Jing; Liu Ruqing

    2011-01-01

    This paper covers a micro sensor analog signal processing circuit system (MASPS) chip with low power and a digital signal processing circuit board implementation including hardware connection and software design.Attention has been paid to incorporate the MASPS chip into the digital circuit board. The ultimate aim is to form a hybrid circuit used for mixed-signal processing, which can be applied to a micro sensor flow monitoring system.

  14. Cross comparison design analysis of analog input signals of TXS system in Tianwan Nuclear Power Plant

    International Nuclear Information System (INIS)

    The paper describes and analyzes the mathematical model and structural design of analog signal input redundant channel cross comparison of TXS system in Tianwan Nuclear Power Plant. The operation practice proves that the design of analog signal input redundant channel cross comparison of TXS system can complete well the task of analog signal channel test and channel breakdown tendency monitoring, and it meets the needs of nuclear safety rules and standards. (authors)

  15. Design and implementation of a hybrid circuit system for micro sensor signal processing

    Energy Technology Data Exchange (ETDEWEB)

    Wang Zhuping; Chen Jing; Liu Ruqing, E-mail: wangzhuping169@163.com [School of Information and Electronics, Beijing Institute of Technology, Beijing 100081 (China)

    2011-04-15

    This paper covers a micro sensor analog signal processing circuit system (MASPS) chip with low power and a digital signal processing circuit board implementation including hardware connection and software design. Attention has been paid to incorporate the MASPS chip into the digital circuit board. The ultimate aim is to form a hybrid circuit used for mixed-signal processing, which can be applied to a micro sensor flow monitoring system. (semiconductor integrated circuits)

  16. PEA System Modeling and Signal Processing for Measurements of Volume Charge Distributions in Thin Dielectric Films

    OpenAIRE

    Pearson, Lee H.; Dennison, JR; Griffiths, Erick W.; Pearson, A. C.

    2016-01-01

    This paper discusses an effort to develop advanced pulsed electroacoustic (PEA) measurement system capabilities that incorporate state-of-the-art hardware and improved signal processing and modeling to characterize embedded charge distributions in thin dielectric films. Objectives in developing this system include: (1) improved spatial resolution, while maintaining reasonable temporal resolution; (2) improved signal processing tools for increased signal/noise ratios; (3) integrated PEA modeli...

  17. Fast optical signal processing in high bit rate OTDM systems

    DEFF Research Database (Denmark)

    Poulsen, Henrik Nørskov; Jepsen, Kim Stokholm; Clausen, Anders; Buxens Azcoaga, Alvaro Juan; Stubkjær, Kristian; Hess, R.; Dülk, M.; Melchior, H.

    As all-optical signal processing is maturing, optical time division multiplexing (OTDM) has also gained interest for simple networking in high capacity backbone networks. As an example of a network scenario we show an OTDM bus interconnecting another OTDM bus, a single high capacity user represen...... represented by an optical termination (OT) and a WDM area...

  18. E-Block: A Tangible Programming Tool with Graphical Blocks

    Directory of Open Access Journals (Sweden)

    Danli Wang

    2013-01-01

    Full Text Available This paper designs a tangible programming tool, E-Block, for children aged 5 to 9 to experience the preliminary understanding of programming by building blocks. With embedded artificial intelligence, the tool defines the programming blocks with the sensors as the input and enables children to write programs to complete the tasks in the computer. The symbol on the programming block's surface is used to help children understanding the function of each block. The sequence information is transferred to computer by microcomputers and then translated into semantic information. The system applies wireless and infrared technologies and provides user with feedbacks on both screen and programming blocks. Preliminary user studies using observation and user interview methods are shown for E-Block's prototype. The test results prove that E-Block is attractive to children and easy to learn and use. The project also highlights potential advantages of using single chip microcomputer (SCM technology to develop tangible programming tools for children.

  19. Uncoupling High Light Responses from Singlet Oxygen Retrograde Signaling and Spatial-Temporal Systemic Acquired Acclimation.

    Science.gov (United States)

    Carmody, Melanie; Crisp, Peter A; d'Alessandro, Stefano; Ganguly, Diep; Gordon, Matthew; Havaux, Michel; Albrecht-Borth, Verónica; Pogson, Barry J

    2016-07-01

    Distinct ROS signaling pathways initiated by singlet oxygen ((1)O2) or superoxide and hydrogen peroxide have been attributed to either cell death or acclimation, respectively. Recent studies have revealed that more complex antagonistic and synergistic relationships exist within and between these pathways. As specific chloroplastic ROS signals are difficult to study, rapid systemic signaling experiments using localized high light (HL) stress or ROS treatments were used in this study to uncouple signals required for direct HL and ROS perception and distal systemic acquired acclimation (SAA). A qPCR approach was chosen to determine local perception and distal signal reception. Analysis of a thylakoidal ascorbate peroxidase mutant (tapx), the (1)O2-retrograde signaling double mutant (ex1/ex2), and an apoplastic signaling double mutant (rbohD/F) revealed that tAPX and EXECUTER 1 are required for both HL and systemic acclimation stress perception. Apoplastic membrane-localized RBOHs were required for systemic spread of the signal but not for local signal induction in directly stressed tissues. Endogenous ROS treatments revealed a very strong systemic response induced by a localized 1 h induction of (1)O2 using the conditional flu mutant. A qPCR time course of (1)O2 induced systemic marker genes in directly and indirectly connected leaves revealed a direct vascular connection component of both immediate and longer term SAA signaling responses. These results reveal the importance of an EXECUTER-dependent (1)O2 retrograde signal for both local and long distance RBOH-dependent acclimation signaling that is distinct from other HL signaling pathways, and that direct vascular connections have a role in spatial-temporal SAA induction. PMID:27288360

  20. Epidural block

    Science.gov (United States)

    ... Drugs & Supplements Videos & Tools Español You Are Here: Home ... It numbs or causes a loss of feeling in the lower half your body. This lessens the pain of contractions during childbirth. An epidural block may also be used to ...

  1. Improvement of Small Signal Stability of SMIB System Using PSO and CSO based Power System Stabilizer

    Directory of Open Access Journals (Sweden)

    Y. Raghuvamsi

    2015-08-01

    Full Text Available In a power system, Low Frequency Oscillations (LFOs are dangerous and make system unstable. These oscillations are referred to small signal stability and they are mainly due to lack of damping torque. This insufficient damping torque is because of high gain and low time constant of Automatic Voltage Regulator (AVR. AVR is useful for maintaining the terminal voltage of synchronous machine as constant. While doing so, it will make the system damping torque as negative. For providing required damping torque thereby minimizing the LFOs, Power System Stabilizer is used in conjunction with AVR. In this paper for SMIB system, the stability is studied with the help of eigen values before and after placement of PSS with optimized PSS parameters using Particle Swarm Optimization (PSO and Cat Swarm Optimization (CSO. The simulation work is performed in the MATLAB/SIMULINK and corresponding results are presented and analyzed.

  2. Establishment of control equations and adjoint equations using block-pulse functions for optimal control of linear systems with time delays

    Institute of Scientific and Technical Information of China (English)

    王兴涛

    2002-01-01

    Control equation and adjoint equation are established by using block-pulse functions, which trans-forms the linear time-varying systems with time delays into a system of algebraic equations and the optimal con-trol problems are transformed into an optimization problem of multivariate functions thereby achieving the opti-mal control of linear systems with time delays.

  3. Building Block Apartments Energy Monitoring Interactive System With Social Case Study

    OpenAIRE

    Meyers, Christophe

    2015-01-01

    This report has two aims. First aim is to evaluate the e_ect of installing a home energy monitoring system on the electrical consumption of inhabitants of a Smart City. Numerous literature urges for the need of more informative energy billing; historic, extra information or comparative feedback. This thesis conducts a further evaluation in scope of further validating these _ndings. Second aim is to compare deployment and performance of Open vs commercial energy monitoring systems. Henc...

  4. Wireless Body Area Network in a Ubiquitous Healthcare System for Physiological Signal Monitoring and Health Consulting

    Directory of Open Access Journals (Sweden)

    Joonyoung Jung

    2008-12-01

    Full Text Available We developed a ubiquitous healthcare system consisted of aphysiological signal devices, a mobile system, a device provider system, a healthcare service provider system, a physician system, and a healthcare personal system. In this system, wireless body area network (WBAN such as ZigBee is used to communicate between physiological signal devices and the mobile system. WBAN device needs a specific function for ubiquitous healthcare application. We propose a scanning algorithm, dynamic discovery and installation, reliable data transmission, device access control, and a healthcare profile for ubiquitous healthcare system.

  5. Phosphate sink containing two-component signaling systems as tunable threshold devices

    DEFF Research Database (Denmark)

    Amin, Munia; Kothamachu, Varun B; Feliu, Elisenda;

    2014-01-01

    Synthetic biology aims to design de novo biological systems and reengineer existing ones. These efforts have mostly focused on transcriptional circuits, with reengineering of signaling circuits hampered by limited understanding of their systems dynamics and experimental challenges. Bacterial two...

  6. Throughput-Distortion Computation Of Generic Matrix Multiplication: Toward A Computation Channel For Digital Signal Processing Systems

    CERN Document Server

    Anastasia, Davide

    2011-01-01

    The generic matrix multiply (GEMM) function is the core element of high-performance linear algebra libraries used in many computationally-demanding digital signal processing (DSP) systems. We propose an acceleration technique for GEMM based on dynamically adjusting the imprecision (distortion) of computation. Our technique employs adaptive scalar companding and rounding to input matrix blocks followed by two forms of packing in floating-point that allow for concurrent calculation of multiple results. Since the adaptive companding process controls the increase of concurrency (via packing), the increase in processing throughput (and the corresponding increase in distortion) depends on the input data statistics. To demonstrate this, we derive the optimal throughput-distortion control framework for GEMM for the broad class of zero-mean, independent identically distributed, input sources. Our approach converts matrix multiplication in programmable processors into a computation channel: when increasing the processi...

  7. LDPC concatenated space-time block coded system in multipath fading environment: Analysis and evaluation

    Directory of Open Access Journals (Sweden)

    Surbhi Sharma

    2011-06-01

    Full Text Available Irregular low-density parity-check (LDPC codes have been found to show exceptionally good performance for single antenna systems over a wide class of channels. In this paper, the performance of LDPC codes with multiple antenna systems is investigated in flat Rayleigh and Rician fading channels for different modulation schemes. The focus of attention is mainly on the concatenation of irregular LDPC codes with complex orthogonal space-time codes. Iterative decoding is carried out with a density evolution method that sets a threshold above which the code performs well. For the proposed concatenated system, the simulation results show that the QAM technique achieves a higher coding gain of 8.8 dB and 3.2 dB over the QPSK technique in Rician (LOS and Rayleigh (NLOS faded environments respectively.

  8. Time-resolved single-photon detection module based on silicon photomultiplier: A novel building block for time-correlated measurement systems

    Science.gov (United States)

    Martinenghi, E.; Di Sieno, L.; Contini, D.; Sanzaro, M.; Pifferi, A.; Dalla Mora, A.

    2016-07-01

    We present the design and preliminary characterization of the first detection module based on Silicon Photomultiplier (SiPM) tailored for single-photon timing applications. The aim of this work is to demonstrate, thanks to the design of a suitable module, the possibility to easily exploit SiPM in many applications as an interesting detector featuring large active area, similarly to photomultipliers tubes, but keeping the advantages of solid state detectors (high quantum efficiency, low cost, compactness, robustness, low bias voltage, and insensitiveness to magnetic field). The module integrates a cooled SiPM with a total photosensitive area of 1 mm2 together with the suitable avalanche signal read-out circuit, the signal conditioning, the biasing electronics, and a Peltier cooler driver for thermal stabilization. It is able to extract the single-photon timing information with resolution better than 100 ps full-width at half maximum. We verified the effective stabilization in response to external thermal perturbations, thus proving the complete insensitivity of the module to environment temperature variations, which represents a fundamental parameter to profitably use the instrument for real-field applications. We also characterized the single-photon timing resolution, the background noise due to both primary dark count generation and afterpulsing, the single-photon detection efficiency, and the instrument response function shape. The proposed module can become a reliable and cost-effective building block for time-correlated single-photon counting instruments in applications requiring high collection capability of isotropic light and detection efficiency (e.g., fluorescence decay measurements or time-domain diffuse optics systems).

  9. Time-resolved single-photon detection module based on silicon photomultiplier: A novel building block for time-correlated measurement systems.

    Science.gov (United States)

    Martinenghi, E; Di Sieno, L; Contini, D; Sanzaro, M; Pifferi, A; Dalla Mora, A

    2016-07-01

    We present the design and preliminary characterization of the first detection module based on Silicon Photomultiplier (SiPM) tailored for single-photon timing applications. The aim of this work is to demonstrate, thanks to the design of a suitable module, the possibility to easily exploit SiPM in many applications as an interesting detector featuring large active area, similarly to photomultipliers tubes, but keeping the advantages of solid state detectors (high quantum efficiency, low cost, compactness, robustness, low bias voltage, and insensitiveness to magnetic field). The module integrates a cooled SiPM with a total photosensitive area of 1 mm(2) together with the suitable avalanche signal read-out circuit, the signal conditioning, the biasing electronics, and a Peltier cooler driver for thermal stabilization. It is able to extract the single-photon timing information with resolution better than 100 ps full-width at half maximum. We verified the effective stabilization in response to external thermal perturbations, thus proving the complete insensitivity of the module to environment temperature variations, which represents a fundamental parameter to profitably use the instrument for real-field applications. We also characterized the single-photon timing resolution, the background noise due to both primary dark count generation and afterpulsing, the single-photon detection efficiency, and the instrument response function shape. The proposed module can become a reliable and cost-effective building block for time-correlated single-photon counting instruments in applications requiring high collection capability of isotropic light and detection efficiency (e.g., fluorescence decay measurements or time-domain diffuse optics systems). PMID:27475542

  10. Blocking Wnt signaling by SFRP-like molecules inhibits in vivo cell proliferation and tumor growth in cells carrying active β-catenin.

    Science.gov (United States)

    Lavergne, E; Hendaoui, I; Coulouarn, C; Ribault, C; Leseur, J; Eliat, P-A; Mebarki, S; Corlu, A; Clément, B; Musso, O

    2011-01-27

    Constitutive activation of Wnt/β-catenin signaling in cancer results from mutations in pathway components, which frequently coexist with autocrine Wnt signaling or epigenetic silencing of extracellular Wnt antagonists. Among the extracellular Wnt inhibitors, the secreted frizzled-related proteins (SFRPs) are decoy receptors that contain soluble Wnt-binding frizzled domains. In addition to SFRPs, other endogenous molecules harboring frizzled motifs bind to and inhibit Wnt signaling. One of such molecules is V3Nter, a soluble SFRP-like frizzled polypeptide that binds to Wnt3a and inhibits Wnt signaling and expression of the β-catenin target genes cyclin D1 and c-myc. V3Nter is derived from the cell surface extracellular matrix component collagen XVIII. Here, we used HCT116 human colon cancer cells carrying the ΔS45 activating mutation in one of the alleles of β-catenin to show that V3Nter and SFRP-1 decrease baseline and Wnt3a-induced β-catenin stabilization. Consequently, V3Nter reduces the growth of human colorectal cancer xenografts by specifically controlling cell proliferation and cell cycle progression, without affecting angiogenesis or apoptosis, as shown by decreased [(3)H]-thymidine (in vitro) or BrdU (in vivo) incorporation, clonogenesis assays, cell cycle analysis and magnetic resonance imaging in living mice. Additionally, V3Nter switches off the β-catenin target gene expression signature in vivo. Moreover, experiments with β-catenin allele-targeted cells showed that the ΔS45 β-catenin allele hampers, but does not abrogate, inhibition of Wnt signaling by SFRP-1 or by the SFRP-like frizzled domain. Finally, neither SFRP-1 nor V3Nter affect β-catenin signaling in SW480 cells carrying nonfunctional Adenomatous polyposis coli. Thus, SFRP-1 and the SFRP-like molecule V3Nter can inhibit tumor growth of β-catenin-activated tumor cells in vivo. PMID:20856206

  11. Signalling components of the house mouse mate recognition system

    Czech Academy of Sciences Publication Activity Database

    Bímová, Barbora; Albrecht, Tomáš; Macholán, Miloš; Piálek, Jaroslav

    2009-01-01

    Roč. 80, č. 1 (2009), s. 20-27. ISSN 0376-6357 R&D Projects: GA AV ČR IAA600930506 Institutional research plan: CEZ:AV0Z60930519; CEZ:AV0Z50450515 Keywords : Faeces * Olfactory communication * Salivary androgen binding protein * Sexual preferences * Urinary signals Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 1.527, year: 2009

  12. Mitochondrial two-component signaling systems in Candida albicans.

    Science.gov (United States)

    Mavrianos, John; Berkow, Elizabeth L; Desai, Chirayu; Pandey, Alok; Batish, Mona; Rabadi, Marissa J; Barker, Katherine S; Pain, Debkumar; Rogers, P David; Eugenin, Eliseo A; Chauhan, Neeraj

    2013-06-01

    Two-component signal transduction pathways are one of the primary means by which microorganisms respond to environmental signals. These signaling cascades originated in prokaryotes and were inherited by eukaryotes via endosymbiotic lateral gene transfer from ancestral cyanobacteria. We report here that the nuclear genome of the pathogenic fungus Candida albicans contains elements of a two-component signaling pathway that seem to be targeted to the mitochondria. The C. albicans two-component response regulator protein Srr1 (stress response regulator 1) contains a mitochondrial targeting sequence at the N terminus, and fluorescence microscopy reveals mitochondrial localization of green fluorescent protein-tagged Srr1. Moreover, phylogenetic analysis indicates that C. albicans Srr1 is more closely related to histidine kinases and response regulators found in marine bacteria than are other two-component proteins present in the fungi. These data suggest conservation of this protein during the evolutionary transition from endosymbiont to a subcellular organelle. We used microarray analysis to determine whether the phenotypes observed with a srr1Δ/Δ mutant could be correlated with gene transcriptional changes. The expression of mitochondrial genes was altered in the srr1Δ/Δ null mutant in comparison to their expression in the wild type. Furthermore, apoptosis increased significantly in the srr1Δ/Δ mutant strain compared to the level of apoptosis in the wild type, suggesting the activation of a mitochondrion-dependent apoptotic cell death pathway in the srr1Δ/Δ mutant. Collectively, this study shows for the first time that a lower eukaryote like C. albicans possesses a two-component response regulator protein that has survived in mitochondria and regulates a subset of genes whose functions are associated with the oxidative stress response and programmed cell death (apoptosis). PMID:23584995

  13. Unveiling Hidden Dynamics of Hippo Signalling: A Systems Analysis.

    Science.gov (United States)

    Shin, Sung-Young; Nguyen, Lan K

    2016-01-01

    The Hippo signalling pathway has recently emerged as an important regulator of cell apoptosis and proliferation with significant implications in human diseases. In mammals, the pathway contains the core kinases MST1/2, which phosphorylate and activate LATS1/2 kinases. The pro-apoptotic function of the MST/LATS signalling axis was previously linked to the Akt and ERK MAPK pathways, demonstrating that the Hippo pathway does not act alone but crosstalks with other signalling pathways to coordinate network dynamics and cellular outcomes. These crosstalks were characterised by a multitude of complex regulatory mechanisms involving competitive protein-protein interactions and phosphorylation mediated feedback loops. However, how these different mechanisms interplay in different cellular contexts to drive the context-specific network dynamics of Hippo-ERK signalling remains elusive. Using mathematical modelling and computational analysis, we uncovered that the Hippo-ERK network can generate highly diverse dynamical profiles that can be clustered into distinct dose-response patterns. For each pattern, we offered mechanistic explanation that defines when and how the observed phenomenon can arise. We demonstrated that Akt displays opposing, dose-dependent functions towards ERK, which are mediated by the balance between the Raf-1/MST2 protein interaction module and the LATS1 mediated feedback regulation. Moreover, Ras displays a multi-functional role and drives biphasic responses of both MST2 and ERK activities; which are critically governed by the competitive protein interaction between MST2 and Raf-1. Our study represents the first in-depth and systematic analysis of the Hippo-ERK network dynamics and provides a concrete foundation for future studies. PMID:27527217

  14. Projected Krylov Methods for Solving Non-Symmetric Two-by-Two Block Linear Systems Arising from Fictitious Domain Formulations

    Directory of Open Access Journals (Sweden)

    Radek Kucera

    2014-01-01

    Full Text Available The paper deals with the solution of large non-symmetric two-by-two block linear systems with a singular leading submatrix. Our algorithm consists of two levels. The outer level combines the Schur complement reduction with the orthogonal projectors that leads to the linear equation on subspaces. To solve this equation, we use a Krylov-type method representing the inner level of the algorithm. We propose a general technique how to get from the standard Krylov methods their projected variants generating iterations on subspaces. Then we derive the projected GMRES. The efficiency of our approach is illustrated by examples arising from the combination of the fictitious domain and FETI method.

  15. FPGA Implementation of Block Parallel DF-MPIC Detectors for DS-CDMA Systems in Frequency-Nonselective Channels

    Directory of Open Access Journals (Sweden)

    Adel Omar Dahmane

    2008-01-01

    Full Text Available Multistage parallel interference cancellation- (MPIC- based detectors allow to mitigate multiple-access interference in direct-sequence code-division multiple-access (DS-CDMA systems. They are considered serious candidates for practical implementation showing a good tradeoff between performance and complexity. Better performance is obtained when decision feedback (DF is employed. Although MPIC and DF-MPIC have the same arithmetic complexity, DF-MPIC needs much more FPGA resources when compared to MPIC without decision feedback. In this letter, FPGA implementation of block parallel DF-MPIC (BP-DF-MPIC is proposed allowing better tradeoff between performance and FPGA area occupancy. To reach an uncoded bit-error rate of 10−3, BP-DF-MPIC shows a 1.5 dB improvement over the MPIC without decision feedback with only 8% increase in FPGA resources compared to 69% for DF-MPIC.

  16. BioWatch - a wrist watch based signal acquisition system for physiological signals including blood pressure.

    Science.gov (United States)

    Thomas, Simi Susan; Nathan, Viswam; Chengzhi Zong; Akinbola, Ebunoluwa; Aroul, Antoine Lourdes Praveen; Philipose, Lijoy; Soundarapandian, Karthikeyan; Xiangrong Shi; Jafari, Roozbeh

    2014-01-01

    A wrist watch based system, which can measure electrocardiogram (ECG) and photoplethysmogram (PPG), is presented in this work. By using both ECG and PPG we also measure pulse transit time (PTT), which studies show to correlate well with blood pressure (BP). The system is also capable of monitoring heart rate using either ECG or PPG and can monitor blood oxygenation by easily replacing the PPG sensors with a different set. In this work, we investigate methods to train a fitting function to convert a PTT measurement to its corresponding systolic BP. We also validate measurements on different postures and show the value of calibrating the device for each posture. This system, called BioWatch, can potentially facilitate continuous and ubiquitous monitoring of ECG, PPG, heart rate, blood oxygenation and BP. PMID:25570444

  17. A Proposed Model for Traffic Signal Preemption Using Global Positioning System (GPS

    Directory of Open Access Journals (Sweden)

    Nikhil Mascarenhas

    2013-07-01

    Full Text Available A Traffic Signal Preemption system is an automated system that allows normal operation of traffic lights at automated signalized intersection s to be preempted. Preemption of signals is generally done to assist emergency vehicles, such a s ambulances, so that response times are reduced and right-of-way is provided in a smooth an d controlled manner. This paper proposes an innovative and cost-effective server-centric mod el to facilitate preemption using a simple mobile phone app which uses Global Positioning Syst em (GPS and a microcontroller which controls traffic signals.

  18. A SystemC-Based Design Methodology for Digital Signal Processing Systems

    Directory of Open Access Journals (Sweden)

    Christian Haubelt

    2007-03-01

    Full Text Available Digital signal processing algorithms are of big importance in many embedded systems. Due to complexity reasons and due to the restrictions imposed on the implementations, new design methodologies are needed. In this paper, we present a SystemC-based solution supporting automatic design space exploration, automatic performance evaluation, as well as automatic system generation for mixed hardware/software solutions mapped onto FPGA-based platforms. Our proposed hardware/software codesign approach is based on a SystemC-based library called SysteMoC that permits the expression of different models of computation well known in the domain of digital signal processing. It combines the advantages of executability and analyzability of many important models of computation that can be expressed in SysteMoC. We will use the example of an MPEG-4 decoder throughout this paper to introduce our novel methodology. Results from a five-dimensional design space exploration and from automatically mapping parts of the MPEG-4 decoder onto a Xilinx FPGA platform will demonstrate the effectiveness of our approach.

  19. Digital system analysis and system identification from engymetric signals in nuclear medicine

    International Nuclear Information System (INIS)

    This dissertation shows the selected possibilities and processes in processing measured physiological data or signals from analysis and identification of special systems and explains them with examples. Apart from the division of the data, the possibilities of data processing, such as filtering, smoothing and fitting to curves are described. The different methods of examining and identifying systems are shown and calculated on empirical or axiomatic models. The solution of systems of differential equations and the digital simulation of these are part of the description of axiomatic models, for models developed for certain physiological processes in the body, using a computer. To describe empirical models, statistical characteristics have to be calculated, such as auto-correlation and cross-correlation, and the various effort density spectra, in order to calculate further transfer functions and to be able to carry out system analysis and identification. In section 4 of the work, the ANALYSE program package is applied to real data, signals measured in nuclear medicine. The solutions described in the individual chapters can be achieved with the programs written in Fortran 5 for the Cyber 76 from Control Data. (orig./MG)

  20. Non-Dioxin-Like Polychlorinated Biphenyls Inhibit G-Protein Coupled Receptor-Mediated Ca2+ Signaling by Blocking Store-Operated Ca2+ Entry.

    Directory of Open Access Journals (Sweden)

    Se-Young Choi

    Full Text Available Polychlorinated biphenyls (PCBs are ubiquitous pollutants which accumulate in the food chain. Recently, several molecular mechanisms by which non-dioxin-like (NDL PCBs mediate neurodevelopmental and neurobehavioral toxicity have been elucidated. However, although the G-protein coupled receptor (GPCR is a significant target for neurobehavioral disturbance, our understanding of the effects of PCBs on GPCR signaling remains unclear. In this study, we investigated the effects of NDL-PCBs on GPCR-mediated Ca2+ signaling in PC12 cells. We found that ortho-substituted 2,2',6-trichlorinated biphenyl (PCB19 caused a rapid decline in the Ca2+ signaling of bradykinin, a typical Gq- and phospholipase Cβ-coupled GPCR, without any effect on its inositol 1,4,5-trisphosphate production. PCB19 reduced thapsigargin-induced sustained cytosolic Ca2+ levels, suggesting that PCB19 inhibits SOCE. The abilities of other NDL-PCBs to inhibit store-operated Ca2+ entry (SOCE were also examined and found to be of similar potencies to that of PCB19. PCB19 also showed a manner equivalent to that of known SOCE inhibitors. PCB19-mediated SOCE inhibition was confirmed by demonstrating the ability of PCB19 to inhibit the SOCE current and thapsigargin-induced Mn2+ influx. These results imply that one of the molecular mechanism by which NDL-PCBs cause neurobehavioral disturbances involves NDL-PCB-mediated inhibition of SOCE, thereby interfering with GPCR-mediated Ca2+ signaling.

  1. Block copolymer battery separator

    Energy Technology Data Exchange (ETDEWEB)

    Wong, David; Balsara, Nitash Pervez

    2016-04-26

    The invention herein described is the use of a block copolymer/homopolymer blend for creating nanoporous materials for transport applications. Specifically, this is demonstrated by using the block copolymer poly(styrene-block-ethylene-block-styrene) (SES) and blending it with homopolymer polystyrene (PS). After blending the polymers, a film is cast, and the film is submerged in tetrahydrofuran, which removes the PS. This creates a nanoporous polymer film, whereby the holes are lined with PS. Control of morphology of the system is achieved by manipulating the amount of PS added and the relative size of the PS added. The porous nature of these films was demonstrated by measuring the ionic conductivity in a traditional battery electrolyte, 1M LiPF.sub.6 in EC/DEC (1:1 v/v) using AC impedance spectroscopy and comparing these results to commercially available battery separators.

  2. A design of an uncooled thermal imaging system to block image blurring using an optimum detector warm shield

    Science.gov (United States)

    Jeong, Junho; Youn, Byungyeol; Shin, Sanghoon; Park, Sangyeong; Kim, Youngjin; Lee, Jungsuk; Kim, Kihong

    2009-05-01

    Uncooled TIS is in the spotlight for its small size and low-voltage operation for personal and portable use compare to other TIS. Generally, uncooled TIS using temperature control by TEC converts the gap between TEC temperature and input-image into voltage by ROIC and outputs the analog image. For cooled detector, it is possible to block undesirable infrared input since F number of the optics and the detector are same but for uncooled detector, it is easy to get undesirable infrared input around because the F numbers are different. It becomes more obvious when temperature gap between the equipment and background gets bigger. For TIS, background temperature easily changes inside the system and around the detector because the radiating heat from the electrical circuit inside the system is getting higher as usage time passes, and it makes worse the non-uniformity output characteristics of the detector. In particular, the temperature change of the system itself which depends on its setting position and other temperaturechanging factors like electrical circuit inside the system make the additional non-uniformity worse which caused by infrared photon radiates from structures which includes optics and detector. This article would indicate the method of minimizing its image blurring which originates from the F number gap between optics and detector.

  3. Multi-Aperture Miniaturized Star Sensors, Modular Building Blocks for Small Satellite AOCS Systems

    OpenAIRE

    Rotteveel, Jeroen; Le Mair, Anita

    2009-01-01

    Accurate attitude determination is an important enabler for micro- and nanosatellite missions. For remote sensing applications and formation flying missions, the attitude of the spacecraft must be known and controlled with a high accuracy. ISIS introduces a modular and scalable attitude determination system based on a multi-aperture miniature star sensor. Based on a patented concept, the Multi-Aperture Baffled Starsensor, the attitude sensor integrates several apertures into a single star tra...

  4. Sequence System Building Blocks: Using a Component Architecture for Sequencing Software

    Science.gov (United States)

    Streiffert, Barbara A.; O'Reilly, Taifun

    2005-01-01

    Over the last few years software engineering has made significant strides in making more flexible architectures and designs possible. However, at the same time, spacecraft have become more complex and flight software has become more sophisticated. Typically spacecraft are often one-of-a-kind entities that have different hardware designs, different capabilities, different instruments, etc. Ground software has become more complex and operations teams have had to learn a myriad of tools that all have different user interfaces and represent data in different ways. At Jet Propulsion Laboratory (JPL) these themes have collided to require an new approach to producing ground system software. Two different groups have been looking at tackling this particular problem. One group is working for the JPL Mars Technology Program in the Mars Science Laboratory (MSL) Focused Technology area. The other group is the JPL Multi-Mission Planning and Sequencing Group . The major concept driving these two approaches on a similar path is to provide software that can be a more cohesive flexible system that provides a act of planning and sequencing system of services. This paper describes the efforts that have been made to date to create a unified approach from these disparate groups.

  5. Sequencing System Building Blocks: Using a Component Architecture for Sequencing Software

    Science.gov (United States)

    Streiffert, Barbara A.; O'Reilly, Taifun

    2006-01-01

    Over the last few years software engineering has made significant strides in making more flexible architectures and designs possible. However, at the same time, spacecraft have become more complex and flight software has become more sophisticated. Typically spacecraft are often one-of-a-kind entities that have different hardware designs, different capabilities, different instruments, etc. Ground software has become more complex and operations teams have had to learn a myriad of tools that all have different user interfaces and represent data in different ways. At Jet Propulsion Laboratory (JPL) these themes have collided to require a new approach to producing ground system software. Two different groups have been looking at tackling this particular problem. One group is working for the JPL Mars Technology Program in the Mars Science Laboratory (MSL) Focused Technology area. The other group is the JPL Multi-Mission Planning and Sequencing Group. The major concept driving these two approaches on a similar path is to provide software that can be a more cohesive flexible system that provides a set of planning and sequencing system of services. This paper describes the efforts that have been made to date to create a unified approach from these disparate groups.

  6. Building blocks of a fish head: Developmental and variational modularity in a complex system.

    Science.gov (United States)

    Lehoux, Caroline; Cloutier, Richard

    2015-11-01

    Evolution of the vertebrate skull is developmentally constrained by the interactions among its anatomical systems, such as the dermatocranium and the sensory system. The interaction between the dermal bones and lateral line canals has been debated for decades but their morphological integration has never been tested. An ontogenetic series of 97 juvenile and adult Amia calva (Actinopterygii) was used to describe the patterning and modularity of sensory lateral line canals and their integration with supporting cranial bones. Developmental modules were tested for the otic canal and supratemporal commissure by computing correlations in the branching sequence of groups of pores. Landmarks were digitized on 25 specimens to test a priori hypotheses of variational and developmental modularity at the level of canals and dermal bones. Branching sequence suggests a specific patterning supported by significant positive correlations in the sequence of appearance of branches between bilateral sides. Differences in patterning between the otic canal and the supratemporal commissure and tests of modularity with geometric morphometrics suggest that both canals form distinct modules. The integration between bones and canals was insufficient to detect a module. However, both components were not independent. Groups of pores tended to disappear without affecting other groups of pores suggesting that they are quasi-independent units acting as modules. This study provides evidence of a hierarchical organization for the modular sensory system that could explain variation of pattern of canals among species and their association with dermal bones. PMID:26227536

  7. Transmission of digital chaotic and information-bearing signals in optical communication systems

    Science.gov (United States)

    Gonzalez-Marcos, Ana P.; Martin-Pereda, Jose A.

    1999-12-01

    A new proposal to have secure communications in a system is reported. The basis is the use of a synchronized digital chaotic systems, sending the information signal added to an initial chaos. The received signal is analyzed by another chaos generator located at the receiver and, by a logic boolean function of the chaotic and the received signals, the original information is recovered. One of the most important facts of this system is that the bandwidth needed by the system remain the same with and without chaos.

  8. Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway

    Directory of Open Access Journals (Sweden)

    Freeman Robert S

    2011-02-01

    Full Text Available Abstract Background Thrombolytic therapy with tissue plasminogen activator (tPA benefits patients with acute ischemic stroke. However, tPA increases the risk for intracerebral bleeding and enhances post-ischemic neuronal injury if administered 3-4 hours after stroke. Therefore, combination therapies with tPA and neuroprotective agents have been considered to increase tPA's therapeutic window and reduce toxicity. The anticoagulant factor protein S (PS protects neurons from hypoxic/ischemic injury. PS also inhibits N-methyl-D-aspartate (NMDA excitotoxicity by phosphorylating Bad and Mdm2 which blocks the downstream steps in the intrinsic apoptotic cascade. To test whether PS can protect neurons from tPA toxicity we studied its effects on tPA/NMDA combined injury which in contrast to NMDA alone kills neurons by activating the extrinsic apoptotic pathway. Neither Bad nor Mdm2 which are PS's targets and control the intrinsic apoptotic pathway can influence the extrinsic cascade. Thus, based on published data one cannot predict whether PS can protect neurons from tPA/NMDA injury by blocking the extrinsic pathway. Neurons express all three TAM (Tyro3, Axl, Mer receptors that can potentially interact with PS. Therefore, we studied whether PS can activate TAM receptors during a tPA/NMDA insult. Results We show that PS protects neurons from tPA/NMDA-induced apoptosis by suppressing Fas-ligand (FasL production and FasL-dependent caspase-8 activation within the extrinsic apoptotic pathway. By transducing neurons with adenoviral vectors expressing the kinase-deficient Akt mutant AktK179A and a triple FKHRL1 Akt phosphorylation site mutant (FKHRL1-TM, we show that Akt activation and Akt-mediated phosphorylation of FKHRL1, a member of the Forkhead family of transcription factors, are critical for FasL down-regulation and caspase-8 inhibition. Using cultured neurons from Tyro3, Axl and Mer mutants, we show that Tyro3, but not Axl and Mer, mediates

  9. Naringin abrogated radiation induced oxidative stress through modulation of redox regulated cellular signaling system

    International Nuclear Information System (INIS)

    Ionizing radiation is widely used as major diagnostic and therapeutic applications. However, the deleterious effects of ionizing radiation are due to generation of reactive oxygen species. The amounts of ionizing radiation that can be given to treat malignant tumours are often limited by toxicity in the surrounding normal tissues and organs. The aim of this study was to investigate the role of Naringin (NG), a natural flavonoid, present in many plant parts against radiation induced oxidative stress with an evidence based exploration of the mechanism involved. Isolated murine splenocyte were irradiated with γ radiation (6 Gy) along with/without different concentrations of NG (50 and 100 μM). Biochemical, immunoblot, flow cytometry and immunofluorescence study was subject to be performed to observe its molecular mechanisms of action. Pretreatment with NG significantly prevented the radiation induced intracellular ROS generation, therefore prevented cellular TBARS formation and development of cellular nitrite. NG showed the significant reduction in nuclear DNA damage with respect to irradiated splenocyte through inhibition of DNA-PKcs and p-γH2AX. It recovered radiation induced reduced cell viability through modulation of redox regulated cell signaling system. It resulted in significant inhibition of radiation induced G1/S phase cell cycle arrest mediated by modulation of p53 dependent p21/WAF1 expression followed by Cyclin E and CDK2 expression. NG was involved in blocking radiation induced p38 function; reversed radiation mediated differential stress response through inhibition of NF-κB pathway. It prevented p-IKKα/β, p-IκBα, p-p65, COX2 expression. It also reversed the radiation induced p38/NF-κB guided inflammatory development. Thus it down regulated radiation induced CRP, MCP-1, and iNOS2 gene expression. This novel role of naringin provides a basis for therapeutic applications in future against radiation induced molecular and cellular functional

  10. Upgrade of control signal distribution system at J-PARC linac

    International Nuclear Information System (INIS)

    Three kinds of timing signals, 12-MHz clock, 25-Hz trigger, and type code (control word), are used in the timing system of J-PARC. The timing signals are generated in the central control room (CCR) and are delivered to each facilities. In the klystron gallery of the linac, these signals are received, divided, and distributed to each station. However, in this distribution system, an optical signal from CCR is transformed to an electrical one by a O/E module and divided by a FANOUT module, and then re-transformed to an optical by E/O module. This system is a source of troubles such as the module failure, the timing trouble of LLRF for temperature drift and so on. Therefore, we would like to update the timing signal distribution system for use of the optical amplifiers and the optical couplers. (author)

  11. Characterization of three digital signal processor systems used in gamma ray spectrometry

    International Nuclear Information System (INIS)

    Various manufacturers have recently introduced digital signal processing systems that allow data acquisition in gamma spectrometry at high-input counting rates (several thousand pulses per second). In these systems, the signal digitization is performed immediately following the preamplification stage. This allows digital shaping and filtering of the signal which increases the number of possible combinations in signal shaping and as a consequence, optimizes the resolution as a function of the detector characteristics and the counting rate. Basic characteristic parameters of three digital signal processors that were recently introduced in the market have been studied and compared to those of an analog system. This study is carried out using a hyper-pure coaxial type germanium detector and 57Co, 60Co and 137Cs radioactive sources. Performance parameters such as energy resolution, system throughput, and counting losses that are due to dead time and pile-up effects are presented and discussed

  12. An enzymatic signal amplification system for calorimetric studies of cellobiohydrolases

    DEFF Research Database (Denmark)

    Murphy, Leigh; Baumann, Martin Johannes; Borch, Kim;

    2010-01-01

    The study of cellulolytic enzymes has traditionally been carried out using endpoint measurements by quantitation of reaction products using high-performance liquid chromatography (HPLC) or overall determination of produced reducing ends. To measure catalytic activity, model substrates such as...... is heat production. This can be converted to the rate of reaction and allows direct and continuous monitoring of the hydrolysis of complex substrates. To overcome the low molar enthalpy of the hydrolysis of the glycosidic bond, which is typically on the order of −2.5 kJ mol−1, an enzymatic signal...

  13. Glossogyne tenuifolia Extract Inhibits TNF-α-Induced Expression of Adhesion Molecules in Human Umbilical Vein Endothelial Cells via Blocking the NF-kB Signaling Pathway.

    Science.gov (United States)

    Hsuan, Chin-Feng; Hsu, Hsia-Fen; Tseng, Wei-Kung; Lee, Thung-Lip; Wei, Yu-Feng; Hsu, Kwan-Lih; Wu, Chau-Chung; Houng, Jer-Yiing

    2015-01-01

    Chronic inflammation plays a pivotal role in the development of atherosclerosis, where the pro-inflammatory cytokine-induced expression of endothelial adhesion molecules and the recruitment of monocytes are the crucial events leading to its pathogenesis. Glossogyne tenuifolia ethanol extract (GTE) is shown to have potent anti-inflammatory and antioxidant activities. We evaluated the effects of GTE and its major components, luteolin (lut), luteolin-7-glucoside (lut-7-g), and oleanolic acid (OA) on TNF-α-induced expression of adhesion molecules in human umbilical vein endothelial cells (HUVECs). The results demonstrated that GTE, lut, and lut-7-g attenuated the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in TNF-α-activated HUVECs, and inhibited the adhesion of monocytes to TNF-α-activated HUVECs. The TNF-α-induced mRNA expression of ICAM-1 and VCAM-1 was also suppressed, revealing their inhibitory effects at the transcriptional level. Furthermore, GTE, lut, and lut-7-g blocked the TNF-α-induced degradation of nuclear factor-kB inhibitor (IkB), an indicator of the activation of nuclear factor-kB (NF-kB). In summary, GTE and its bioactive components were effective in preventing the adhesion of monocytes to cytokine-activated endothelium by the inhibition of expression of adhesion molecules, which in turn is mediated through blocking the activation and nuclear translocation of NF-kB. The current results reveal the therapeutic potential of GTE in atherosclerosis. PMID:26393541

  14. Overexpression of KiSS-1 reduces colorectal cancer cell invasion by downregulating MMP-9 via blocking PI3K/Akt/NF-κB signal pathway.

    Science.gov (United States)

    Chen, Shaoqin; Chen, Wei; Zhang, Xiang; Lin, Suyong; Chen, Zhihua

    2016-04-01

    Metastasis of colorectal cancer (CRC) depends critically on MMP-9. KiSS-1 is a human malignant melanoma metastasis-suppressor gene. Thus, the interaction between MMP-9 and KiSS-1 has drawn considerable attention in recent years. In the present study, it was hypothesized that KiSS-1 gene could repress the metastatic potential of colorectal cancer cells by inhibiting the expression of MMP-9. Stable transfection of KiSS-1 specific siRNA and KiSS-1 expression vector in human CRC cell line HCT-116 was achieved by lentivirus infection. Moreover, the cell proliferation, invasiveness, and apoptosis were evaluated by CCK-8 method, transwell experiment, and fluorescence activated cell sorter, respectively. We also investigated the expression of MMP-9, PI3K, Akt, pAKt, and NF-кB subunit p65 using western blotting. KiSS-1 overexpression significantly decreased the cell proliferation and invasiveness of HCT-119 cells, while apoptosis was enhanced. The result of western blotting showed that synthesis of MMP-9, PI3K, p65, and phosphorylation of Akt were significantly blocked by overexpression of KiSS-1. Concatenated treatment of KiSS-1 overexpression vector with PI3K and Akt agonists attenuated the effect of KiSS-1 on the biological activity of CRC cells and also released the expression of MMP-9, PI3K, p65, and phosphorylation of Akt from the influence of overexpression of KiSS-1. Overexpression of KiSS-1 suppressed the invasiveness of CRC cells, and the gene exerted its function by reducing the expression of MMP-9 via blocking of tge PI3K/Akt/NF-κB pathway. PMID:26847533

  15. The Signal Detection and Control Circuit Design for Confocal Auto-Focus System

    Directory of Open Access Journals (Sweden)

    Yin Liu

    2016-01-01

    Full Text Available Based on the demands of Confocal Auto-Focus system, the implementation method of signal measurement circuit and control circuit is given. Using the high performance instrumental amplifier AD620BN, low noise precision FET Op amplifier AD795JRZ and ultralow offset voltage Op amplifier OP07EP, a signal measurement circuit used to converse the two differential light intensity signal to electric signal is designed. And a control circuit which takes MCU MSP430F149 as core processes the former signal and generate a control signal driving the platform for auto-focusing. The experimental results proved the feasibility and correctness of circuits. And the system meets the design requirement.

  16. Method for signal conditioning and data acquisition system, based on variable amplification and feedback technique

    International Nuclear Information System (INIS)

    An original method of signal conditioning and adaptive amplification is proposed for data acquisition systems of analog signals, conceived to obtain a high resolution spectrum of any input signal. The procedure is based on a feedback scheme of the signal amplification with aim at maximizing the dynamic range and resolution of the data acquisition system. The paper describes the signal conditioning, digitization, and data processing procedures applied to an a priori unknown signal in order to enucleate its amplitude and frequency content for applications in different environments: on the ground, in space, or in the laboratory. An electronic board of the conditioning module has also been constructed and described. In the paper are also discussed the main fields of application and advantages of the method with respect to those known today

  17. Method for signal conditioning and data acquisition system, based on variable amplification and feedback technique

    Energy Technology Data Exchange (ETDEWEB)

    Conti, Livio, E-mail: livio.conti@uninettunouniversity.net [Facoltà di Ingegneria, Università Telematica Internazionale Uninettuno, Corso Vittorio Emanuele II 39, 00186 Rome, Italy INFN Sezione Roma Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome (Italy); Sgrigna, Vittorio [Dipartimento di Matematica e Fisica, Università Roma Tre, 84 Via della Vasca Navale, I-00146 Rome (Italy); Zilpimiani, David [National Institute of Geophysics, Georgian Academy of Sciences, 1 M. Alexidze St., 009 Tbilisi, Georgia (United States); Assante, Dario [Facoltà di Ingegneria, Università Telematica Internazionale Uninettuno, Corso Vittorio Emanuele II 39, 00186 Rome, Italy INFN Sezione Roma Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome (Italy)

    2014-08-21

    An original method of signal conditioning and adaptive amplification is proposed for data acquisition systems of analog signals, conceived to obtain a high resolution spectrum of any input signal. The procedure is based on a feedback scheme of the signal amplification with aim at maximizing the dynamic range and resolution of the data acquisition system. The paper describes the signal conditioning, digitization, and data processing procedures applied to an a priori unknown signal in order to enucleate its amplitude and frequency content for applications in different environments: on the ground, in space, or in the laboratory. An electronic board of the conditioning module has also been constructed and described. In the paper are also discussed the main fields of application and advantages of the method with respect to those known today.

  18. Classification of EEG Signals by Radial Neuro-Fuzzy Systems

    Czech Academy of Sciences Publication Activity Database

    Coufal, David

    2006-01-01

    Roč. 5, č. 2 (2006), s. 415-423. ISSN 1109-2777 R&D Projects: GA MŠk ME 701 Institutional research plan: CEZ:AV0Z10300504 Keywords : neuro-fuzzy systems * radial fuzzy systems * data mining * hybrid systems Subject RIV: BA - General Mathematics

  19. Enhancement of the automatic ultrasonic signal processing system using digital technology

    International Nuclear Information System (INIS)

    The objective of this study is to develop the automatic ultrasonic signal processing system which can be used in the inspection equipment to assess the integrity of the reactor vessel by enhancing the performance of the ultrasonic signal processing system. Main activities of this study divided into three categories such as the development of the circuits for generating ultrasonic signal and receiving the signal from the inspection equipment, the development of signal processing algorithm and H/W of the data processing system, and the development of the specification for application programs and system S/W for the analysis and evaluation computer. The results of main activities are as follows 1) the design of the ultrasonic detector and the automatic ultrasonic signal processing system by using the investigation of the state-of-the-art technology in the inside and outside of the country. 2) the development of H/W and S/W of the data processing system based on the results. Especially, the H/W of the data processing system, which have both advantages of digital and analog controls through the real-time digital signal processing, was developed using the DSP which can process the digital signal in the real-time, and was developed not only firmware of the data processing system in order for the peripherals but also the test algorithm of specimen for the calibration. The application programs and the system S/W of the analysis/evaluation computer were developed. Developed equipment was verified by the performance test. Based on developed prototype for the automatic ultrasonic signal processing system, the localization of the overall ultrasonic inspection equipment for nuclear industries would be expected through the further studies of the H/W establishment of real applications, developing the S/W specification of the analysis computer. (author)

  20. Enhancement of the automatic ultrasonic signal processing system using digital technology

    Energy Technology Data Exchange (ETDEWEB)

    Koo, In Soo; Park, H. Y.; Suh, Y. S.; Kim, D. Hoon; Huh, S.; Sung, S. H.; Jang, G. S.; Ryoo, S. G.; Choi, J. H.; Kim, Y. H.; Lee, J. C.; Kim, D. Hyun; Park, H. J.; Kim, Y. C.; Lee, J. P.; Park, C. H.; Kim, M. S

    1999-12-01

    The objective of this study is to develop the automatic ultrasonic signal processing system which can be used in the inspection equipment to assess the integrity of the reactor vessel by enhancing the performance of the ultrasonic signal processing system. Main activities of this study divided into three categories such as the development of the circuits for generating ultrasonic signal and receiving the signal from the inspection equipment, the development of signal processing algorithm and H/W of the data processing system, and the development of the specification for application programs and system S/W for the analysis and evaluation computer. The results of main activities are as follows 1) the design of the ultrasonic detector and the automatic ultrasonic signal processing system by using the investigation of the state-of-the-art technology in the inside and outside of the country. 2) the development of H/W and S/W of the data processing system based on the results. Especially, the H/W of the data processing system, which have both advantages of digital and analog controls through the real-time digital signal processing, was developed using the DSP which can process the digital signal in the real-time, and was developed not only firmware of the data processing system in order for the peripherals but also the test algorithm of specimen for the calibration. The application programs and the system S/W of the analysis/evaluation computer were developed. Developed equipment was verified by the performance test. Based on developed prototype for the automatic ultrasonic signal processing system, the localization of the overall ultrasonic inspection equipment for nuclear industries would be expected through the further studies of the H/W establishment of real applications, developing the S/W specification of the analysis computer. (author)