WorldWideScience

Sample records for block signal systems

  1. Peak Power Demand and Energy Consumption Reduction Strategies for Trains under Moving Block Signalling System

    OpenAIRE

    Qing Gu; Tao Tang; Fang Cao; Hamid Reza Karimi; Yongduan Song

    2013-01-01

    In the moving block signalling (MBS) system where the tracking target point of the following train is moving forward with its leading train, overload of the substations occurs when a dense queue of trains starts (or restarts) in very close distance interval. This is the peak power demand problem. Several methods have been attempted in the literature to deal with this problem through changing train's operation strategies. However, most existing approaches reduce the service quality. In this pa...

  2. Integration between anticipatory blocking and redox signaling by the peroxiredoxin/thioredoxin/thioredoxin-reductase system.

    Science.gov (United States)

    Selvaggio, Gianluca; Coelho, Pedro M B M; Salvador, Armindo

    2014-10-01

    Cells are occasionally exposed to high H2O2 concentrations, often preceding exposure to other electrophylic compounds. Both H2O2 and these compounds can irreversibly modify protein thiols, with deleterious consequences. Induction of enzymatic defenses against those agents is too slow to avoid significant damage. Cells may solve this conundrum by reversibly "blocking" the thiols once H2O2 concentrations begin to increase. We term this mechanism "anticipatory blocking" because it acts in anticipation of irreversible damage upon detection of early signs of stress. Here we examine the design requirements for the Peroxiredoxin/Thioredoxin/Thioredoxin-Reductase/Protein-Dithiol System (PTTRDS) to effectively integrate H2O2 signaling and anticipatory blocking of protein dithiols as disulfides, and we compared them to the designs found in cells. To that effect, we developed a minimal model of the PTTRDS, and we defined a set of quantitative performance criteria that embody the requirements for (a) efficient scavenging capacity, (b) low NADPH consumption, (c) effective signal propagation, and (d) effective anticipatory blocking. We then sought the design principles (relationships among rate constants and species concentrations) that warrant fulfillment of all these criteria. Experimental data indicates that the design of the PTTRDS in human erythrocytes fulfills these principles and thus accomplishes effective integration between anticipatory blocking, antioxidant protection and redox signaling. A more general analysis suggests that the same principles hold in a wide variety of cell types and organisms. We acknowledge grants PEst-C/SAU/LA0001/2013-2014, PEst-OE/QUI/UI0612/2013, FCOMP-01-0124-FEDER-020978 (PTDC/QUI-BIQ/119657/2010) financed by FEDER through the "Programa Operacional Factores de Competitividade, COMPETE" and by national funds through "FCT, Fundação para a Ciência e a Tecnologia".

  3. Signal-Conditioning Block of a 1 × 200 CMOS Detector Array for a Terahertz Real-Time Imaging System

    Directory of Open Access Journals (Sweden)

    Jong-Ryul Yang

    2016-03-01

    Full Text Available A signal conditioning block of a 1 × 200 Complementary Metal-Oxide-Semiconductor (CMOS detector array is proposed to be employed with a real-time 0.2 THz imaging system for inspecting large areas. The plasmonic CMOS detector array whose pixel size including an integrated antenna is comparable to the wavelength of the THz wave for the imaging system, inevitably carries wide pixel-to-pixel variation. To make the variant outputs from the array uniform, the proposed signal conditioning block calibrates the responsivity of each pixel by controlling the gate bias of each detector and the voltage gain of the lock-in amplifiers in the block. The gate bias of each detector is modulated to 1 MHz to improve the signal-to-noise ratio of the imaging system via the electrical modulation by the conditioning block. In addition, direct current (DC offsets of the detectors in the array are cancelled by initializing the output voltage level from the block. Real-time imaging using the proposed signal conditioning block is demonstrated by obtaining images at the rate of 19.2 frame-per-sec of an object moving on the conveyor belt with a scan width of 20 cm and a scan speed of 25 cm/s.

  4. Biomedical signals and systems

    CERN Document Server

    Tranquillo, Joseph V

    2013-01-01

    Biomedical Signals and Systems is meant to accompany a one-semester undergraduate signals and systems course. It may also serve as a quick-start for graduate students or faculty interested in how signals and systems techniques can be applied to living systems. The biological nature of the examples allows for systems thinking to be applied to electrical, mechanical, fluid, chemical, thermal and even optical systems. Each chapter focuses on a topic from classic signals and systems theory: System block diagrams, mathematical models, transforms, stability, feedback, system response, control, time

  5. Macrocell Builder: IP-Block-Based Design Environment for High-Throughput VLSI Dedicated Digital Signal Processing Systems

    Directory of Open Access Journals (Sweden)

    Urard Pascal

    2006-01-01

    Full Text Available We propose an efficient IP-block-based design environment for high-throughput VLSI systems. The flow generates SystemC register-transfer-level (RTL architecture, starting from a Matlab functional model described as a netlist of functional IP. The refinement model inserts automatically control structures to manage delays induced by the use of RTL IPs. It also inserts a control structure to coordinate the execution of parallel clocked IP. The delays may be managed by registers or by counters included in the control structure. The flow has been used successfully in three real-world DSP systems. The experimentations show that the approach can produce efficient RTL architecture and allows to save huge amount of time.

  6. 49 CFR 236.512 - Cab signal indication when locomotive enters block where restrictive conditions obtain.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Cab signal indication when locomotive enters block... TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic Train Stop, Train Control and Cab Signal Systems Standards § 236.512 Cab signal indication when locomotive enters block where...

  7. Support agnostic Bayesian matching pursuit for block sparse signals

    KAUST Repository

    Masood, Mudassir

    2013-05-01

    A fast matching pursuit method using a Bayesian approach is introduced for block-sparse signal recovery. This method performs Bayesian estimates of block-sparse signals even when the distribution of active blocks is non-Gaussian or unknown. It is agnostic to the distribution of active blocks in the signal and utilizes a priori statistics of additive noise and the sparsity rate of the signal, which are shown to be easily estimated from data and no user intervention is required. The method requires a priori knowledge of block partition and utilizes a greedy approach and order-recursive updates of its metrics to find the most dominant sparse supports to determine the approximate minimum mean square error (MMSE) estimate of the block-sparse signal. Simulation results demonstrate the power and robustness of our proposed estimator. © 2013 IEEE.

  8. VLSI mixed signal processing system

    Science.gov (United States)

    Alvarez, A.; Premkumar, A. B.

    1993-01-01

    An economical and efficient VLSI implementation of a mixed signal processing system (MSP) is presented in this paper. The MSP concept is investigated and the functional blocks of the proposed MSP are described. The requirements of each of the blocks are discussed in detail. A sample application using active acoustic cancellation technique is described to demonstrate the power of the MSP approach.

  9. Block diagonal and schur complement preconditioners for block-toeplitz systems with small size blocks

    OpenAIRE

    Ching, WK; Ng, MK; Wen, YW

    2007-01-01

    In this paper we consider the solution of Hermitian positive definite block-Toeplitz systems with small size blocks. We propose and study block diagonal and Schur complement preconditioners for such block-Toeplitz matrices. We show that for some block-Toeplitz matrices, the spectra of the preconditioned matrices are uniformly bounded except for a fixed number of outliers where this fixed number depends only on the size of the block. Hence, conjugate gradient type methods, when applied to solv...

  10. Abscisic Acid Signal off the STARTing Block

    Institute of Scientific and Technical Information of China (English)

    Archana Joshi-Saha; Christiane Valon; Jeffrey Leung

    2011-01-01

    The year 2009 marked a real turnaround in our understanding of the mode ot abscisJc acid(ABA)action. Nearly 25 years had elapsed since the first biochemical detection of ABA-binding proteins in the plasmalemma of Vicia guard cells was reported. This recent-and laudable-achievement is owed largely to the discovery of the soluble ABA receptors whose major interacting proteins happen to be some of the most well-established components of earliest steps in ABA signaling. These soluble receptors, with the double name of PYRABACTIN RESISTANCE (PYR)or REGULATORY COM-PONENT OF ABA RECEPTOR (RCAR), are a family of Arabidopsis proteins of about 150-200 amino acids that share a con-served START domain. The ABA signal transduction circuitry under non-stress conditions is muted by the ciade A protein phosphatases 2C (PP2C)(notably HAB1, ABI1, and ABI2). During the initial steps of ABA signaling, the binding of the hor-mone to the receptor induces a conformational change in the latter that allows it to sequester the PP2Cs. This excludes them from the negative regulation of the downstream ABA-activated kinases (OST1/SnRK2.6/SRK2E, SnRK2.2, and SnRK2.3), thus unleashing the pathway by freeing them to phosphorylate downstream targets that now include several b-ZIP transcription factors, ion channels (SLAC1, KAT1), and a NADPH oxidase (AtrbohF). The discovery of this family of soluble receptors and the rich insight already gained from structural studies of their complexes with different isoforms of ABA, PP2C, and the synthetic agonist pyrabactin lay the foundation towards rational design of chemical switches that can bolster drought hardiness in plants.

  11. A Signal Coordination Control Based on Traversing Empty between Mid-Block Street Crossing and Intersection

    Directory of Open Access Journals (Sweden)

    Changjiang Zheng

    2012-01-01

    Full Text Available To solve the problem in pedestrian Mid-Block street crossing, the method of signal coordination control between mid-block street crossing and intersection is researched in this paper. The paper proposes to use “distance-flow rate-time” graph as the tool for building coordination control system model which is for different situations of traffic control. Through alternating the linear optimization model, the system outputs the distribution of signal timing and system operational factors (delays in vehicles and mid-block street crossing. Finally, taking one section on the Taiping North Road in Nanjing as an example, the signal coordination control is carried out. And the results which are delays in the vehicles and mid-block street crossing are compared to those in the current distribution of signal timing.

  12. Curcumin blocks interleukin-1 signaling in chondrosarcoma cells.

    Directory of Open Access Journals (Sweden)

    Thomas Kalinski

    Full Text Available Interleukin (IL-1 signaling plays an important role in inflammatory processes, but also in malignant processes. The essential downstream event in IL-1 signaling is the activation of nuclear factor (NF-κB, which leads to the expression of several genes that are involved in cell proliferation, invasion, angiogenesis and metastasis, among them VEGF-A. As microenvironment-derived IL-1β is required for invasion and angiogenesis in malignant tumors, also in chondrosarcomas, we investigated IL-1β-induced signal transduction and VEGF-A expression in C3842 and SW1353 chondrosarcoma cells. We additionally performed in vitro angiogenesis assays and NF-κB-related gene expression analyses. Curcumin is a substance which inhibits IL-1 signaling very early by preventing the recruitment of IL-1 receptor associated kinase (IRAK to the IL-1 receptor. We demonstrate that IL-1 signaling and VEGF-A expression are blocked by Curcumin in chondrosarcoma cells. We further show that Curcumin blocks IL-1β-induced angiogenesis and NF-κB-related gene expression. We suppose that IL-1 blockade is an additional treatment option in chondrosarcoma, either by Curcumin, its derivatives or other IL-1 blocking agents.

  13. Building blocks for embedded control systems

    NARCIS (Netherlands)

    Broenink, Jan F.; Hilderink, Gerald H.; Bakkers, André W.P.; Veen, Jean Pierre

    2000-01-01

    Developing embedded control systems using a building-block approach at all the parts enables an efficient and fast design process. Main reasons are the real plug-and-play capabilities of the blocks. Furthermore, due the simulatability of the designs, parts of the system can already be tested before

  14. Signal Space Separation method with block matrix inversion for extraction of signals in magnetoencephalography

    Science.gov (United States)

    Baskaran, R.; Janawadkar, M. P.

    2012-10-01

    Signal Space Separation (SSS) method is a technique utilized to eliminate the contribution of unwanted signals due to external magnetic noise that inevitably get recorded along with the actual magnetic signal due to neuronal currents in the brain. In this paper, the SSS method has been implemented using block matrix inversion. By implementing block matrix inversion along with regrouping of radial terms, it has been possible to extract the true brain signal from the measured magnetic signal which includes the contribution from an external magnetic dipole artifact for measurements from as few as 64 channels. We observe that the minimum root mean square deviation (RMSD) of the signal inferred from block matrix inversion with regrouped terms is around 6 fT when the truncation order is set at L1 = 11 for signals of interest and L2 = 2 for external noise sources and saturates to similar values for higher L1. The RMSD of extracted signal is 50% smaller than the minimum RMSD when the magnetoencephalography signal is extracted by direct pseudoinverse technique and does not have a deep minimum in the truncation order L1 as observed when direct pseudoinverse technique is used.

  15. Block methods for linear Hamiltonian systems

    OpenAIRE

    Tian, Hongjiong; Chen, Bailin

    2014-01-01

    For the numerical treatment of Hamiltonian differential equations,symplectic integrators are regarded as the most suitable choice.In this paper we are concerned with the applicability of block methods for the discrete approximate solution of linear Hamiltonian systems.The k-dimensional block methods are convergent of order at least k+1 for ordinary differential equations.We provide conditions on the coefficients of the equivalent block methods in order to maintain two important properties of...

  16. Combined parametric-nonparametric identification of block-oriented systems

    CERN Document Server

    Mzyk, Grzegorz

    2014-01-01

    This book considers a problem of block-oriented nonlinear dynamic system identification in the presence of random disturbances. This class of systems includes various interconnections of linear dynamic blocks and static nonlinear elements, e.g., Hammerstein system, Wiener system, Wiener-Hammerstein ("sandwich") system and additive NARMAX systems with feedback. Interconnecting signals are not accessible for measurement. The combined parametric-nonparametric algorithms, proposed in the book, can be selected dependently on the prior knowledge of the system and signals. Most of them are based on the decomposition of the complex system identification task into simpler local sub-problems by using non-parametric (kernel or orthogonal) regression estimation. In the parametric stage, the generalized least squares or the instrumental variables technique is commonly applied to cope with correlated excitations. Limit properties of the algorithms have been shown analytically and illustrated in simple experiments.

  17. Criminal Justice Systems. Block I: Law Enforcement. Block II: The Courts. Block III: Corrections. Block IV: Community Relations. Block V: Proficiency Skills. Block VI: Criminalistics. Student Guide.

    Science.gov (United States)

    Florida State Dept. of Education, Tallahassee. Div. of Vocational, Adult, and Community Education.

    This student guide together with an instructor guide comprise a set of curriculum materials on the criminal justice system. The student guide contains self-contained instructional material that students can study at their own pace most of the time. Six major subject areas or blocks, which are further broken down into several units, with some units…

  18. Criminal Justice Systems. Block I: Law Enforcement. Block II: The Courts. Block III: Corrections. Block IV: Community Relations. Block V: Proficiency Skills. Block VI: Criminalistics. Instructor Guide.

    Science.gov (United States)

    Florida State Dept. of Education, Tallahassee. Div. of Vocational, Adult, and Community Education.

    This instructor guide together with a student guide comprise a set of curriculum materials on the criminal justice system. The instructor guide is a resource for planning and managing individualized, competency-based instruction in six major subject areas or blocks, which are further broken down into several units with some units having several…

  19. Quantum Integrable Systems from Conformal Blocks

    CERN Document Server

    Chen, Heng-Yu

    2016-01-01

    In this note, we extend the striking connections between quantum integrable systems and conformal blocks recently found in http://arxiv.org/abs/1602.01858 in several directions. First, we explicitly demonstrate that the action of quartic conformal Casimir operator on general d-dimensional scalar conformal blocks, can be expressed in terms of certain combinations of commuting integrals of motions of the two particle hyperbolic BC2 Calogero-Sutherland system. The permutation and reflection properties of the underlying Dunkl operators play crucial roles in establishing such a connection. Next, we show that the scalar superconformal blocks in SCFTs with four and eight supercharges and suitable chirality constraints can also be identified with the eigenfunctions of the same Calogero-Sutherland system, this demonstrates the universality of such a connection. Finally, we observe that the so-called "seed" conformal blocks for constructing four point functions for operators with arbitrary space-time spins in four dime...

  20. Controlling systems of cogeneration blocks

    International Nuclear Information System (INIS)

    In this article the main parts of cogeneration unit control system are described. Article is aimed on electric power measurement with electricity protection as with temperature system regulation. In conclusion of the article, the control algorithm with perspective of cogeneration solve is indicated. (authors)

  1. Modularity in signaling systems

    International Nuclear Information System (INIS)

    Modularity is a property by which the behavior of a system does not change upon interconnection. It is crucial for understanding the behavior of a complex system from the behavior of the composing subsystems. Whether modularity holds in biology is an intriguing and largely debated question. In this paper, we discuss this question taking a control system theory view and focusing on signaling systems. In particular, we argue that, despite signaling systems being constituted of structural modules, such as covalent modification cycles, modularity does not hold in general. As in any engineering system, impedance-like effects, called retroactivity, appear at interconnections and alter the behavior of connected modules. We further argue that while signaling systems have evolved sophisticated ways to counter-act retroactivity and enforce modularity, retroactivity may also be exploited to finely control the information processing of signaling pathways. Testable predictions and experimental evidence are discussed with their implications. (paper)

  2. Building Blocks for Control System Software

    NARCIS (Netherlands)

    Broenink, J.F.; Hilderink, G.H.; Amerongen van, J.; Jonker, B.; Regtien, P.P.L.

    2001-01-01

    Software implementation of control laws for industrial systems seem straightforward, but is not. The computer code stemming from the control laws is mostly not more than 10 to 30% of the total. A building-block approach for embedded control system development is advocated to enable a fast and effici

  3. Efficient Recovery of Block Sparse Signals via Zero-point Attracting Projection

    OpenAIRE

    Liu, Jingbo; Jin, Jian; Gu, Yuantao

    2012-01-01

    In this paper, we consider compressed sensing (CS) of block-sparse signals, i.e., sparse signals that have nonzero coefficients occurring in clusters. An efficient algorithm, called zero-point attracting projection (ZAP) algorithm, is extended to the scenario of block CS. The block version of ZAP algorithm employs an approximate $l_{2,0}$ norm as the cost function, and finds its minimum in the solution space via iterations. For block sparse signals, an analysis of the stability of the local m...

  4. Continuous signals and systems with Matlab

    CERN Document Server

    ElAli, Taan

    2008-01-01

    Designed for a one-semester undergraduate course in continuous linear systems, Continuous Signals and Systems with MATLAB®, Second Edition presents the tools required to design, analyze, and simulate dynamic systems. It thoroughly describes the process of the linearization of nonlinear systems, using MATLAB® to solve most examples and problems. With updates and revisions throughout, this edition focuses more on state-space methods, block diagrams, and complete analog filter design. New to the Second Edition           A chapter on block diagrams that covers various classical and state-space

  5. Efficient Recovery of Block Sparse Signals via Zero-point Attracting Projection

    CERN Document Server

    Liu, Jingbo; Gu, Yuantao

    2012-01-01

    In this paper, we consider compressed sensing (CS) of block-sparse signals, i.e., sparse signals that have nonzero coefficients occurring in clusters. An efficient algorithm, called zero-point attracting projection (ZAP) algorithm, is extended to the scenario of block CS. The block version of ZAP algorithm employs an approximate $l_{2,0}$ norm as the cost function, and finds its minimum in the solution space via iterations. For block sparse signals, an analysis of the stability of the local minimums of this cost function under the perturbation of noise reveals an advantage of the proposed algorithm over its original non-block version in terms of reconstruction error. Finally, numerical experiments show that the proposed algorithm outperforms other state of the art methods for the block sparse problem in various respects, especially the stability under noise.

  6. UV light blocks EGFR signalling in human cancer cell lines

    DEFF Research Database (Denmark)

    Olsen, BB; Neves-Petersen, M T; Klitgaard, S;

    2007-01-01

    antibodies. There was a threshold level, below which the receptor could not be blocked. In addition, illumination caused the cells to upregulate the cyclin-dependent kinase inhibitor p21WAF1, irrespective of the p53 status. Since the EGF receptor is often overexpressed in cancers and other proliferative skin......UV light excites aromatic residues, causing these to disrupt nearby disulphide bridges. The EGF receptor is rich in aromatic residues near the disulphide bridges. Herein we show that laser-pulsed UV illumination of two different skin-derived cancer cell lines i.e. Cal-39 and A431, which both...

  7. BLOCK BIDIAGONALIZATION METHODS FOR MULTIPLE NONSYMMETRIC LINEAR SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    戴华

    2001-01-01

    The symmetric linear system gives us many simplifications and a possibility to adapt the computations to the computer at hand in order to achieve better performance. The aim of this paper is to consider the block bidiagonalization methods derived from a symmetric augmented multiple linear systems and make a comparison with the block GMRES and block biconjugate gradient methods.

  8. Signals and systems for dummies

    CERN Document Server

    Wickert, Mark

    2013-01-01

    Getting mixed signals in your signals and systems course? The concepts covered in a typical signals and systems course are often considered by engineering students to be some of the most difficult to master. Thankfully, Signals & Systems For Dummies is your intuitive guide to this tricky course, walking you step-by-step through some of the more complex theories and mathematical formulas in a way that is easy to understand. From Laplace Transforms to Fourier Analyses, Signals & Systems For Dummies explains in plain English the difficult concepts that can trip you up

  9. A SIGNALING MODEL OF CONTROL BLOCK SALES BY ENTREPRENEURS

    OpenAIRE

    Lynda S. Livingston

    2007-01-01

    In this paper, we present a model in which higher-valued managers signal their value by voluntarily submitting to shareholder oversight. If a manager is willing to sell enough stock to release voting control, he is perceived to be of higher quality than if he had defensively maintained control. The implication of the model is that voluntary/control sales by insiders can be good news for the firm. This is consistent with the share-price increases that follow the deaths of entrenched managers.

  10. Wireless data signal transmission system

    DEFF Research Database (Denmark)

    2014-01-01

    The present invention relates to a method for providing a radio frequency signal for transmission, a system for providing a radio frequency signal for transmission and a method for wireless data transmission between a transmitter and a receiver.......The present invention relates to a method for providing a radio frequency signal for transmission, a system for providing a radio frequency signal for transmission and a method for wireless data transmission between a transmitter and a receiver....

  11. Acoustic Signals and Systems

    DEFF Research Database (Denmark)

    2008-01-01

    The Handbook of Signal Processing in Acoustics will compile the techniques and applications of signal processing as they are used in the many varied areas of Acoustics. The Handbook will emphasize the interdisciplinary nature of signal processing in acoustics. Each Section of the Handbook...... will present topics on signal processing which are important in a specific area of acoustics. These will be of interest to specialists in these areas because they will be presented from their technical perspective, rather than a generic engineering approach to signal processing. Non-specialists, or specialists...... from different areas, will find the self-contained chapters accessible and will be interested in the similarities and differences between the approaches and techniques used in different areas of acoustics....

  12. Growth-Blocking Peptides As Nutrition-Sensitive Signals for Insulin Secretion and Body Size Regulation.

    Science.gov (United States)

    Koyama, Takashi; Mirth, Christen K

    2016-02-01

    In Drosophila, the fat body, functionally equivalent to the mammalian liver and adipocytes, plays a central role in regulating systemic growth in response to nutrition. The fat body senses intracellular amino acids through Target of Rapamycin (TOR) signaling, and produces an unidentified humoral factor(s) to regulate insulin-like peptide (ILP) synthesis and/or secretion in the insulin-producing cells. Here, we find that two peptides, Growth-Blocking Peptide (GBP1) and CG11395 (GBP2), are produced in the fat body in response to amino acids and TOR signaling. Reducing the expression of GBP1 and GBP2 (GBPs) specifically in the fat body results in smaller body size due to reduced growth rate. In addition, we found that GBPs stimulate ILP secretion from the insulin-producing cells, either directly or indirectly, thereby increasing insulin and insulin-like growth factor signaling activity throughout the body. Our findings fill an important gap in our understanding of how the fat body transmits nutritional information to the insulin producing cells to control body size. PMID:26928023

  13. Design and Implementation of Noise Free Audio Speech Signal Using Fast Block Least Mean Square Algorithm

    Directory of Open Access Journals (Sweden)

    J. Jebastine

    2012-06-01

    Full Text Available This paper describes the development of an adaptive noise cancellation algorithm for effective recognition of speech signal and also to improve SNR for an adaptive step size input. An adaptive filter with Fast Block Least Mean square Algorithm is designed for noise free audio (speech/music signals. The signal input used is a audio speech signal which could be in the form of a recorded voice. The filter used is adaptive filter and the algorithm used is Fast Block LMS algorithm. A Gaussian noise is added to this input signal and given as a input to the Fast Block LMS. The algorithm is implemented in Matlab and was tested for noise cancellation in speech signals. A Simulink model is designed which results in a noise free audio speech signal at the output. The FBLMS algorithm is computationally efficient in noise cancellation. The noise level in speech signal can be 1 mild, 2 moderate, 3 severe. The SNR is estimated by varying the adaptive step size.

  14. Design and Implementation of Noise Free Audio Speech Signal Using Fast Block Least Mean Square Algorithm

    Directory of Open Access Journals (Sweden)

    J. Jebastine

    2012-07-01

    Full Text Available This paper describes the development of an adaptive noise cancellation algorithm for effective recognition of speech signal and also to improve SNR for an adaptive step size input. An adaptive filter with Fast Block Least Mean square Algorithm is designed for noise free audio (speech/music signals. The signal input used is a audio speech signal which could be in the form of a recorded voice. The filter used is adaptive filter and the algorithm used is Fast Block LMS algorithm. A Gaussian noise is added to this input signal and given as a input to the Fast Block LMS. The algorithm is implemented in Matlab and was tested fornoise cancellation in speech signals. A Simulink model is designed which results in a noise free audiospeech signal at the output. The FBLMS algorithm is computationally efficient in noise cancellation. The noise level in speech signal can be 1 mild, 2 moderate, 3 severe. The SNR is estimated by varying the adaptive step size.

  15. Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells.

    Directory of Open Access Journals (Sweden)

    Xing Chen

    Full Text Available Signal abnormalities in human cells usually cause unexpected consequences for individual health. We focus on these kinds of events involved in JAK-STAT signal pathways, especially the ones triggered by aberrant activated STAT3, an oncoprotein which participates in essential processes of cell survival, growth and proliferation in many types of tumors, as well as immune diseases. By establishing a STAT3 signal based high-throughput drug screening system in human lung cancer A549 cells, we have screened a library from natural products which contained purified compounds from medicinal herbs. One compound, named Brevilin A, exhibited both strong STAT3 signal inhibition and STAT3 signal dependent cell growth inhibition. Further investigations revealed that Brevilin A not only inhibits STAT3 signaling but also STAT1 signaling for cytokines induced phosphorylation of STAT3 and STAT1 as well as the expression of their target genes. In addition, we found Brevilin A could attenuate the JAKs activity by blocking the JAKs tyrosine kinase domain JH1. The levels of cytokine induced phosphorylation of STATs and other substrates were dramatically reduced by treatment of Brevilin A. The roles of Brevilin A targeting on JAKs activity indicate that Brevilin A may not only be used as a STAT3 inhibitor but also a compound blocking other JAK-STAT hyperactivation. Thus, these findings provided a strong impetus for the development of selective JAK-STAT inhibitors and therapeutic drugs in order to improve survival of patients with hyperactivated JAKs and STATs.

  16. New Preconditioners for Nonsymmetric Saddle Point Systems with Singular Block

    OpenAIRE

    Qingbing Liu

    2013-01-01

    We investigate the solution of large linear systems of saddle point type with singular (1,1) block by preconditioned iterative methods and consider two parameterized block triangular preconditioners used with Krylov subspace methods which have the attractive property of improved eigenvalue clustering with increased ill-conditioning of the (1,1) block of the saddle point matrix, including the choice of the parameter. Meanwhile, we analyze the spectral characteristics of two preconditioners and...

  17. Solving block linear systems with low-rank off-diagonal blocks is easily parallelizable

    Energy Technology Data Exchange (ETDEWEB)

    Menkov, V. [Indiana Univ., Bloomington, IN (United States)

    1996-12-31

    An easily and efficiently parallelizable direct method is given for solving a block linear system Bx = y, where B = D + Q is the sum of a non-singular block diagonal matrix D and a matrix Q with low-rank blocks. This implicitly defines a new preconditioning method with an operation count close to the cost of calculating a matrix-vector product Qw for some w, plus at most twice the cost of calculating Qw for some w. When implemented on a parallel machine the processor utilization can be as good as that of those operations. Order estimates are given for the general case, and an implementation is compared to block SSOR preconditioning.

  18. Signals and systems with MATLAB

    CERN Document Server

    Yang, Won Young; Song, Ik H; Cho, Yong S

    2009-01-01

    Covers some of the theoretical foundations and mathematical derivations that can be used in higher-level related subjects such as signal processing, communication, and control, minimizing the mathematical difficulty and computational burden. This book illustrates the usage of MATLAB and Simulink for signal and system analysis and design.

  19. COMPRESSED SPEECH SIGNAL SENSING BASED ON THE STRUCTURED BLOCK SPARSITY WITH PARTIAL KNOWLEDGE OF SUPPORT

    Institute of Scientific and Technical Information of China (English)

    Ji Yunyun; Yang Zhen; Xu Qian

    2012-01-01

    Structural and statistical characteristics of signals can improve the performance of Compressed Sensing (CS).Two kinds of features of Discrete Cosine Transform (DCT) coefficients of voiced speech signals are discussed in this paper.The first one is the block sparsity of DCT coefficients of voiced speech formulated from two different aspects which are the distribution of the DCT coefficients of voiced speech and the comparison of reconstruction performance between the mixed l2 /l1 program and Basis Pursuit (BP).The block sparsity of DCT coefficients of voiced speech means that some algorithms of block-sparse CS can be used to improve the recovery performance of speech signals.It is proved by the simulation results of the l2 / reweighted l1 mixed program which is an improved version of the mixed l2 /l1 program.The second one is the well known large DCT coefficients of voiced speech focus on low frequency.In line with this feature,a special Gaussian and Partial Identity Joint (GPIJ)matrix is constructed as the sensing matrix for voiced speech signals.Simulation results show that the GPIJ matrix outperforms the classical Gaussian matrix for speech signals of male and female adults.

  20. Block Fusion Systems and the Center of the Group Ring

    DEFF Research Database (Denmark)

    Jacobsen, Martin Wedel

    This thesis develops some aspects of the theory of block fusion systems. Chapter 1 contains a brief introduction to the group algebra and some simple results about algebras over a field of positive characteristic. In chapter 2 we define the concept of a fusion system and the fundamental property ...... algebra is one-dimensional. Chapter 4 consists of a proof that block fusion systems of symmetric groups are always group fusion systems of symmetric groups, and an analogous result holds for the alternating groups.......This thesis develops some aspects of the theory of block fusion systems. Chapter 1 contains a brief introduction to the group algebra and some simple results about algebras over a field of positive characteristic. In chapter 2 we define the concept of a fusion system and the fundamental property...... of saturation. We also define block fusion systems and prove that they are saturated. Chapter 3 develops some tools for relating block fusion systems to the structure of the center of the group algebra. In particular, it is proven that a block has trivial defect group if and only if the center of the block...

  1. Block Preconditioned SSOR Methods for -Matrices Linear Systems

    OpenAIRE

    Zhao-Nian Pu; Xue-Zhong Wang

    2013-01-01

    We present a block preconditioner and consider block preconditioned SSOR iterative methods for solving linear system $Ax=b$ . When $A$ is an $H$ -matrix, the convergence and some comparison results of the spectral radius for our methods are given. Numerical examples are also given to illustrate that our methods are valid.

  2. Handbook of signal processing systems

    CERN Document Server

    Deprettere, Ed; Leupers, Rainer; Takala, Jarmo

    2013-01-01

    Handbook of Signal Processing Systems is organized in three parts. The first part motivates representative applications that drive and apply state-of-the art methods for design and implementation of signal processing systems; the second part discusses architectures for implementing these applications; the third part focuses on compilers and simulation tools, describes models of computation and their associated design tools and methodologies. This handbook is an essential tool for professionals in many fields and researchers of all levels.

  3. Block Preconditioners for Complex Symmetric Linear System with Two-by-Two Block Form

    Directory of Open Access Journals (Sweden)

    Shi-Liang Wu

    2015-01-01

    Full Text Available Based on the previous work by Zhang and Zheng (A parameterized splitting iteration method for complex symmetric linear systems, Japan J. Indust. Appl. Math., 31 (2014 265–278, three block preconditioners for complex symmetric linear system with two-by-two block form are presented. Spectral properties of the preconditioned matrices are discussed in detail. It is shown that all the eigenvalues of the preconditioned matrices are well-clustered. Numerical experiments are reported to illustrate the efficiency of the proposed preconditioners.

  4. Pilot Signal Design for Massive MIMO Systems: A Received Signal-To-Noise-Ratio-Based Approach

    Science.gov (United States)

    So, Jungho; Kim, Donggun; Lee, Yuni; Sung, Youngchul

    2015-05-01

    In this paper, the pilot signal design for massive MIMO systems to maximize the training-based received signal-to-noise ratio (SNR) is considered under two channel models: block Gauss-Markov and block independent and identically distributed (i.i.d.) channel models. First, it is shown that under the block Gauss-Markov channel model, the optimal pilot design problem reduces to a semi-definite programming (SDP) problem, which can be solved numerically by a standard convex optimization tool. Second, under the block i.i.d. channel model, an optimal solution is obtained in closed form. Numerical results show that the proposed method yields noticeably better performance than other existing pilot design methods in terms of received SNR.

  5. Systemic defense signaling in tomato

    Institute of Scientific and Technical Information of China (English)

    LI Changbao; SUN Jiaqiang; JIANG Hongling; WU Xiaoyan; LI Chuanyou

    2005-01-01

    The wound-inducible expression of proteinase inhibitors (PIs) genes in tomato provides a powerful model system to elucidate the signal transduction pathway of sys- temic defense response. An increasing body of evidence indi- cates that systemin and jasmonic acid (JA) work in the same signaling pathway to activate the expression of PIs and other defense-related genes. However, little is known about how systemin and JA interact to regulate cell to cell communica- tion over long distances. Genetic analysis of the systemin/JA signaling pathway in tomato plants provides a unique opportunity to dissect the mechanism by which peptide and oxylipin signals interact to coordinate systemic expression of defense-related genes. Previously, it has been proposed that systemin is the long-distance mobile signal for systemic expression of defense related genes. However, recent genetic approach provided new evidence that jasmonic acid, rather than systemin, functions as the systemic wound signal, and that the peptide systemin works to regulate the biosynthesis of JA.

  6. Nonselective block by La3+ of Arabidopsis ion channels involved in signal transduction

    Science.gov (United States)

    Lewis, B. D.; Spalding, E. P.; Evans, M. L. (Principal Investigator)

    1998-01-01

    Lanthanide ions such as La3+ are frequently used as blockers to test the involvement of calcium channels in plant and animal signal transduction pathways. For example, the large rise in cytoplasmic Ca2+ concentration triggered by cold shock in Arabidopsis seedlings is effectively blocked by 10 mM La3+ and we show here that the simultaneous large membrane depolarization is similarly blocked. However, a pharmacological tool is only as useful as it is selective and the specificity of La3+ for calcium channels was brought into question by our finding that it also blocked a blue light (BL)-induced depolarization that results from anion channel activation and believed not to involve calcium channels. This unexpected inhibitory effect of La3+ on the BL-induced depolarization is explained by our finding that 10 mM La3+ directly and completely blocked the BL-activated anion channel when applied to excised patches. We have investigated the ability of La3+ to block noncalcium channels in Arabidopsis. In addition to the BL-activated anion channel, 10 mM La3+ blocked a cation channel and a stretch-activated channel in patches of plasma membrane excised from hypocotyl cells. In root cells, 10 mM La3+ inhibited the activity of an outward-rectifying potassium channel at the whole cell and single-channel level by 47% and 58%, respectively. We conclude that La3+ is a nonspecific blocker of multiple ionic conductances in Arabidopsis and may disrupt signal transduction processes independently of any effect on Ca2+ channels.

  7. Modular Analysis of Almost Block Diagonal Systems of Equations

    OpenAIRE

    El-Mistikawy, Tarek M. A.

    2013-01-01

    Almost block diagonal linear systems of equations can be exemplified by two modules. This makes it possible to construct all sequential forms of band and/or block elimination methods, six old and fourteen new. It allows easy assessment of the methods on the basis of their operation counts, storage needs, and admissibility of partial pivoting. It unveils a robust partial pivoting strategy- local pivoting. Extension of modular analysis to bordered systems is also included.

  8. Block Iterative Reweighted Algorithms for Super-Resolution of Spectrally Sparse Signals

    OpenAIRE

    Cho, Myung; Mishra, Kumar Vijay; Cai, Jian-Feng; Xu, Weiyu

    2015-01-01

    We propose novel algorithms that enhance the performance of recovering unknown continuous-valued frequencies from undersampled signals. Our iterative reweighted frequency recovery algorithms employ the support knowledge gained from earlier steps of our algorithms as block prior information to enhance frequency recovery. Our methods improve the performance of the atomic norm minimization which is a useful heuristic in recovering continuous-valued frequency contents. Numerical results demonstra...

  9. New adhesive systems based on functionalized block copolymers

    Energy Technology Data Exchange (ETDEWEB)

    Kent, M.; Saunders, R.; Hurst, M.; Small, J.; Emerson, J.; Zamora, D.

    1997-05-01

    The goal of this work was to evaluate chemically-functionalized block copolymers as adhesion promoters for metal/thermoset resin interfaces. Novel block copolymers were synthesized which contain pendant functional groups reactive toward copper and epoxy resins. In particular, imidazole and triazole functionalities that chelate with copper were incorporated onto one block, while secondary amines were incorporated onto the second block. These copolymers were found to self-assemble from solution onto copper surfaces to form monolayers. The structure of the adsorbed monolayers were studied in detail by neutron reflection and time-of-flight secondary ion mass spectrometry. The monolayer structure was found to vary markedly with the solution conditions and adsorption protocol. Appropriate conditions were found for which the two blocks form separate layers on the surface with the amine functionalized block exposed at the air surface. Adhesion testing of block copolymer-coated copper with epoxy resins was performed in both lap shear and peel modes. Modest enhancements in bond strengths were observed with the block copolymer applied to the native oxide. However, it was discovered that the native oxide is the weak link, and that by simply removing the native oxide, and then applying an epoxy resin before the native oxide can reform, excellent bond strength in the as-prepared state as well as excellent retention of bond strength after exposure to solder in ambient conditions are obtained. It is recommended that long term aging studies be performed with and without the block copolymer. In addition, the functionalized block copolymer method should be evaluated for another system that has inherently poor bonding, such as the nickel/silicone interface, and for systems involving metals and alloys which form oxides very rapidly, such as aluminum and stainless steel, where bonding strategies involve stabilizing the native oxide.

  10. Morbillivirus v proteins exhibit multiple mechanisms to block type 1 and type 2 interferon signalling pathways.

    Directory of Open Access Journals (Sweden)

    Senthil K Chinnakannan

    Full Text Available Morbilliviruses form a closely related group of pathogenic viruses which encode three non-structural proteins V, W and C in their P gene. Previous studies with rinderpest virus (RPV and measles virus (MeV have demonstrated that these non-structural proteins play a crucial role in blocking type I (IFNα/β and type II (IFNγ interferon action, and various mechanisms have been proposed for these effects. We have directly compared four important morbilliviruses, rinderpest (RPV, measles virus (MeV, peste des petits ruminants virus (PPRV and canine distemper virus (CDV. These viruses and their V proteins could all block type I IFN action. However, the viruses and their V proteins had varying abilities to block type II IFN action. The ability to block type II IFN-induced gene transcription correlated with co-precipitation of STAT1 with the respective V protein, but there was no correlation between co-precipitation of either STAT1 or STAT2 and the abilities of the V proteins to block type I IFN-induced gene transcription or the creation of the antiviral state. Further study revealed that the V proteins of RPV, MeV, PPRV and CDV could all interfere with phosphorylation of the interferon-receptor-associated kinase Tyk2, and the V protein of highly virulent RPV could also block the phosphorylation of another such kinase, Jak1. Co-precipitation studies showed that morbillivirus V proteins all form a complex containing Tyk2 and Jak1. This study highlights the ability of morbillivirus V proteins to target multiple components of the IFN signalling pathways to control both type I and type II IFN action.

  11. Signal processing and linear systems

    CERN Document Server

    Lathi, B P

    1998-01-01

    This text presents a comprehensive treatment of signal processing and linear systems suitable for juniors and seniors in electrical engineering. Based on B. P. Lathi's widely used book, Linear Systems and Signals, it features additional applications to communications, controls, and filtering as well as new chapters on analog and digital filters and digital signal processing. Lathi emphasizes the physical appreciation of concepts rather than the mere mathematical manipulation of symbols. Avoiding the tendency to treat engineering as a branch of applied mathematics, he uses mathematics to enhance physical and intuitive understanding of concepts, instead of employing it only to prove axiomatic theory. Theoretical results are supported by carefully chosen examples and analogies, allowing students to intuitively discover meaning for themselves.

  12. Adaptive Multi-Layered Space-Time Block Coded Systems in Wireless Environments

    KAUST Repository

    Al-Ghadhban, Samir

    2014-12-23

    © 2014, Springer Science+Business Media New York. Multi-layered space-time block coded systems (MLSTBC) strike a balance between spatial multiplexing and transmit diversity. In this paper, we analyze the block error rate performance of MLSTBC. In addition, we propose an adaptive MLSTBC schemes that are capable of accommodating the channel signal-to-noise ratio variation of wireless systems by near instantaneously adapting the uplink transmission configuration. The main results demonstrate that significant effective throughput improvements can be achieved while maintaining a certain target bit error rate.

  13. Block Sparse Compressed Sensing of Electroencephalogram (EEG Signals by Exploiting Linear and Non-Linear Dependencies

    Directory of Open Access Journals (Sweden)

    Hesham Mahrous

    2016-02-01

    Full Text Available This paper proposes a compressive sensing (CS method for multi-channel electroencephalogram (EEG signals in Wireless Body Area Network (WBAN applications, where the battery life of sensors is limited. For the single EEG channel case, known as the single measurement vector (SMV problem, the Block Sparse Bayesian Learning-BO (BSBL-BO method has been shown to yield good results. This method exploits the block sparsity and the intra-correlation (i.e., the linear dependency within the measurement vector of a single channel. For the multichannel case, known as the multi-measurement vector (MMV problem, the Spatio-Temporal Sparse Bayesian Learning (STSBL-EM method has been proposed. This method learns the joint correlation structure in the multichannel signals by whitening the model in the temporal and the spatial domains. Our proposed method represents the multi-channels signal data as a vector that is constructed in a specific way, so that it has a better block sparsity structure than the conventional representation obtained by stacking the measurement vectors of the different channels. To reconstruct the multichannel EEG signals, we modify the parameters of the BSBL-BO algorithm, so that it can exploit not only the linear but also the non-linear dependency structures in a vector. The modified BSBL-BO is then applied on the vector with the better sparsity structure. The proposed method is shown to significantly outperform existing SMV and also MMV methods. It also shows significant lower compression errors even at high compression ratios such as 10:1 on three different datasets.

  14. Handbook of signal processing systems

    CERN Document Server

    Bhattacharyya, Shuvra S; Leupers, Rainer; Takala, Jarmo

    2010-01-01

    The Handbook is organized in four parts. The first part motivates representative applications that drive and apply state-of-the art methods for design and implementation of signal processing systems; the second part discusses architectures for implementing these applications; the third part focuses on compilers and simulation tools; and the fourth part describes models of computation and their associated design tools and methodologies.

  15. QuaBingo: A Prediction System for Protein Quaternary Structure Attributes Using Block Composition

    Science.gov (United States)

    Tung, Chi-Hua; Chen, Chi-Wei; Guo, Ren-Chao; Ng, Hui-Fuang

    2016-01-01

    Background. Quaternary structures of proteins are closely relevant to gene regulation, signal transduction, and many other biological functions of proteins. In the current study, a new method based on protein-conserved motif composition in block format for feature extraction is proposed, which is termed block composition. Results. The protein quaternary assembly states prediction system which combines blocks with functional domain composition, called QuaBingo, is constructed by three layers of classifiers that can categorize quaternary structural attributes of monomer, homooligomer, and heterooligomer. The building of the first layer classifier uses support vector machines (SVM) based on blocks and functional domains of proteins, and the second layer SVM was utilized to process the outputs of the first layer. Finally, the result is determined by the Random Forest of the third layer. We compared the effectiveness of the combination of block composition, functional domain composition, and pseudoamino acid composition of the model. In the 11 kinds of functional protein families, QuaBingo is 23% of Matthews Correlation Coefficient (MCC) higher than the existing prediction system. The results also revealed the biological characterization of the top five block compositions. Conclusions. QuaBingo provides better predictive ability for predicting the quaternary structural attributes of proteins.

  16. QuaBingo: A Prediction System for Protein Quaternary Structure Attributes Using Block Composition

    Directory of Open Access Journals (Sweden)

    Chi-Hua Tung

    2016-01-01

    Full Text Available Background. Quaternary structures of proteins are closely relevant to gene regulation, signal transduction, and many other biological functions of proteins. In the current study, a new method based on protein-conserved motif composition in block format for feature extraction is proposed, which is termed block composition. Results. The protein quaternary assembly states prediction system which combines blocks with functional domain composition, called QuaBingo, is constructed by three layers of classifiers that can categorize quaternary structural attributes of monomer, homooligomer, and heterooligomer. The building of the first layer classifier uses support vector machines (SVM based on blocks and functional domains of proteins, and the second layer SVM was utilized to process the outputs of the first layer. Finally, the result is determined by the Random Forest of the third layer. We compared the effectiveness of the combination of block composition, functional domain composition, and pseudoamino acid composition of the model. In the 11 kinds of functional protein families, QuaBingo is 23% of Matthews Correlation Coefficient (MCC higher than the existing prediction system. The results also revealed the biological characterization of the top five block compositions. Conclusions. QuaBingo provides better predictive ability for predicting the quaternary structural attributes of proteins.

  17. QuaBingo: A Prediction System for Protein Quaternary Structure Attributes Using Block Composition.

    Science.gov (United States)

    Tung, Chi-Hua; Chen, Chi-Wei; Guo, Ren-Chao; Ng, Hui-Fuang; Chu, Yen-Wei

    2016-01-01

    Background. Quaternary structures of proteins are closely relevant to gene regulation, signal transduction, and many other biological functions of proteins. In the current study, a new method based on protein-conserved motif composition in block format for feature extraction is proposed, which is termed block composition. Results. The protein quaternary assembly states prediction system which combines blocks with functional domain composition, called QuaBingo, is constructed by three layers of classifiers that can categorize quaternary structural attributes of monomer, homooligomer, and heterooligomer. The building of the first layer classifier uses support vector machines (SVM) based on blocks and functional domains of proteins, and the second layer SVM was utilized to process the outputs of the first layer. Finally, the result is determined by the Random Forest of the third layer. We compared the effectiveness of the combination of block composition, functional domain composition, and pseudoamino acid composition of the model. In the 11 kinds of functional protein families, QuaBingo is 23% of Matthews Correlation Coefficient (MCC) higher than the existing prediction system. The results also revealed the biological characterization of the top five block compositions. Conclusions. QuaBingo provides better predictive ability for predicting the quaternary structural attributes of proteins. PMID:27610389

  18. Heart Block

    Science.gov (United States)

    ... the signal causes the heart to contract and pump blood. Heart block occurs if the electrical signal is ... degree heart block limits the heart's ability to pump blood to the rest of the body. This type ...

  19. Integration specially intended for a signal processing system. Structures of programmed and micro-programmed operators for signal processing

    International Nuclear Information System (INIS)

    The aim is to describe the development of programmed and micro-programmed system for signal processing (accumulation, histogram, Fourier transform, correlation, convolution, digital filtering etc...). The following points will be discussed: possibilities and limitations of systems based on universal computers, addition of specialized terminals, specialized computers for signal processing. Two typical laboratory studies will be described: adaptation of basic type advanced languages to signal processing, description of a new structure of operators suitable for treatments of repetitive algorithms on blocks of data

  20. Applied signal processing concepts, circuits, and systems

    CERN Document Server

    Hamdy, Nadder

    2008-01-01

    Introduction What are Signals? Signal parameters Why Signal processing? Analog vs. Digital Signal processing Practical Signal processing Systems Analog Signal Processing Amplitude Shaping Frequency Spectrum Shaping Phase Errors Correction Waveform Generation Analog Filter Design Describing Equations Design Procedures Filter Specifications Approximations to the Ideal Response Realization Practical RC-Filters Design Switched Capacitor Filter Realization Design examples Data Converters Introduction A typical DSP System Specifications of Data Converters Sampling Samp

  1. EFFECT OF PEDESTRIANS UN-SIGNALIZED MID-BLOCK CROSSING ON VEHICULAR SPEED

    Directory of Open Access Journals (Sweden)

    B Raghuram Kadali

    2015-06-01

    Full Text Available Pedestrian is one of the important component in urban transportation system and also vulnerable at un-protected mid-block locations under mixed traffic conditions. At un-protected mid-block locations, some of the vehicles may yield to pedestrians who are already at crosswalk location. However, some of the pedestrians are using forced gaps to cross the road. Hence, while pedestrians use the mid-block crosswalk with forced gaps, which decreases the vehicular flow characteristics. The pedestrian sidewalks do not show a direct effect on the vehicular flow characteristics when the pedestrian have pleasant walking facilities. The present study has analyzed the effect of pedestrian crossing on the characteristics of vehicular flow at mid-block location under mixed traffic conditions. The results indicate that the pedestrian forced gap condition has significant effect on vehicular characteristics. The study results may be useful for decreasing the travel time for vehicular drivers by controlling usage of pedestrian forced gaps.

  2. 49 CFR 236.514 - Interconnection of cab signal system with roadway signal system.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Interconnection of cab signal system with roadway signal system. 236.514 Section 236.514 Transportation Other Regulations Relating to Transportation... Interconnection of cab signal system with roadway signal system. The automatic cab signal system shall...

  3. Comparison of dimensionality reduction techniques for the fault diagnosis of mono block centrifugal pump using vibration signals

    Directory of Open Access Journals (Sweden)

    N.R. Sakthivel

    2014-03-01

    Full Text Available Bearing fault, Impeller fault, seal fault and cavitation are the main causes of breakdown in a mono block centrifugal pump and hence, the detection and diagnosis of these mechanical faults in a mono block centrifugal pump is very crucial for its reliable operation. Based on a continuous acquisition of signals with a data acquisition system, it is possible to classify the faults. This is achieved by the extraction of features from the measured data and employing data mining approaches to explore the structural information hidden in the signals acquired. In the present study, statistical features derived from the vibration data are used as the features. In order to increase the robustness of the classifier and to reduce the data processing load, dimensionality reduction is necessary. In this paper dimensionality reduction is performed using traditional dimensionality reduction techniques and nonlinear dimensionality reduction techniques. The effectiveness of each dimensionality reduction technique is also verified using visual analysis. The reduced feature set is then classified using a decision tree. The results obtained are compared with those generated by classifiers such as Naïve Bayes, Bayes Net and kNN. The effort is to bring out the better dimensionality reduction technique–classifier combination.

  4. Random matrix theory for pseudo-Hermitian systems: Cyclic blocks

    Indian Academy of Sciences (India)

    Sudhir R Jain; Shashi C L Srivastava

    2009-12-01

    We discuss the relevance of random matrix theory for pseudo-Hermitian systems, and, for Hamiltonians that break parity and time-reversal invariance . In an attempt to understand the random Ising model, we present the treatment of cyclic asymmetric matrices with blocks and show that the nearest-neighbour spacing distributions have the same form as obtained for the matrices with scalar entries. We also summarize the theory for random cyclic matrices with scalar entries. We have also found that for block matrices made of Hermitian and pseudo-Hermitian sub-blocks of the form appearing in Ising model depart from the known results for scalar entries. However, there is still similarity in trends even in log–log plots.

  5. PN Sequence Preestimator Scheme for DS-SS Signal Acquisition Using Block Sequence Estimation

    Directory of Open Access Journals (Sweden)

    Sang Kyu Park

    2005-03-01

    Full Text Available An m-sequence (PN sequence preestimator scheme for direct-sequence spread spectrum (DS-SS signal acquisition by using block sequence estimation (BSE is proposed and analyzed. The proposed scheme consists of an estimator and a verifier which work according to the PN sequence chip clock, and provides not only the enhanced chip estimates with a threshold decision logic and one-chip error correction among the first m received chips, but also the reliability check of the estimates with additional decision logic. The probabilities of the estimator and verifier operations are calculated. With these results, the detection, the false alarm, and the missing probabilities of the proposed scheme are derived. In addition, using a signal flow graph, the average acquisition time is calculated. The proposed scheme can be used as a preestimator and easily implemented by changing the internal signal path of a generally used digital matched filter (DMF correlator or any other correlator that has a lot of sampling data memories for sampled PN sequence. The numerical results show rapid acquisition performance in a relatively good CNR.

  6. PN Sequence Preestimator Scheme for DS-SS Signal Acquisition Using Block Sequence Estimation

    Science.gov (United States)

    Hyun, Kwangmin; Yoon, Dongweon; Park, Sang Kyu

    2005-12-01

    An [InlineEquation not available: see fulltext.]-sequence (PN sequence) preestimator scheme for direct-sequence spread spectrum (DS-SS) signal acquisition by using block sequence estimation (BSE) is proposed and analyzed. The proposed scheme consists of an estimator and a verifier which work according to the PN sequence chip clock, and provides not only the enhanced chip estimates with a threshold decision logic and one-chip error correction among the first [InlineEquation not available: see fulltext.] received chips, but also the reliability check of the estimates with additional decision logic. The probabilities of the estimator and verifier operations are calculated. With these results, the detection, the false alarm, and the missing probabilities of the proposed scheme are derived. In addition, using a signal flow graph, the average acquisition time is calculated. The proposed scheme can be used as a preestimator and easily implemented by changing the internal signal path of a generally used digital matched filter (DMF) correlator or any other correlator that has a lot of sampling data memories for sampled PN sequence. The numerical results show rapid acquisition performance in a relatively good CNR.

  7. Stability and Stabilization of Block-cascading Switched Linear Systems

    Institute of Scientific and Technical Information of China (English)

    Ya-Hong Zhu; Dai-Zhan Cheng

    2006-01-01

    The main purpose of this paper is to investigate the problem of quadratic stability and stabilization in switched linear systems using reducible Lie algebra. First, we investigate the structure of all real invariant subspaces for a given linear system. The result is then used to provide a comparable cascading form for switching models. Using the commoncascading form, a common quadratic Lyapunov function is (QLFs) is explored by finding common QLFs of diagonal blocks.In addition, a cascading Quaker Lemma is proved. Combining it with stability results, the problem of feedback stabilization for a class of switched linear systems is solved.

  8. User selection strategies for multiuser MIMO systems with block diagonalization

    Institute of Scientific and Technical Information of China (English)

    ZHOU Bei; XU Ning; WANG Ying; ZHANG Ping

    2008-01-01

    Block diagonalization (BD) is an efficient precodingtechnique that eliminates inter-user interference in downlinkmultiple-input multiple-output (MIMO) systems. User selectionstrategies applied to multiuser MIMO systems with BD areinvestigated in this article. To enhance the capacity of multiuserMIMO systems, an equivalent capacity maximum (ECM) userselection strategy is proposed with low computational complexity.Considering both the factors of channel correlations andchannel conditions, the proposed strategy can select a group ofusers to serve for maximizing the total throughput. Simulationresults indicate that, for various channel conditions, proposedECM strategy gains a better performance compared withtraditional user selection strategies, and achieves a near optimalthroughput as the exhaustive search.

  9. Energy-Efficient Full Diversity Collaborative Unitary Space-Time Block Code Design via Unique Factorization of Signals

    CERN Document Server

    Xia, Dong; Dumitrescu, Sorina

    2011-01-01

    In this paper, a novel concept called a \\textit{uniquely factorable constellation pair} (UFCP) is proposed for the systematic design of a noncoherent full diversity collaborative unitary space-time block code by normalizing two Alamouti codes for a wireless communication system having two transmitter antennas and a single receiver antenna. It is proved that such a unitary UFCP code assures the unique identification of both channel coefficients and transmitted signals in a noise-free case as well as full diversity for the noncoherent maximum likelihood (ML) receiver in a noise case. To further improve error performance, an optimal unitary UFCP code is designed by appropriately and uniquely factorizing a pair of energy-efficient cross quadrature amplitude modulation (QAM) constellations to maximize the coding gain subject to a transmission bit rate constraint. After a deep investigation of the fractional coding gain function, a technical approach developed in this paper to maximizing the coding gain is to caref...

  10. Investigating complex patterns of blocked intestinal artery blood pressure signals by empirical mode decomposition and linguistic analysis

    Science.gov (United States)

    Yeh, J.-R.; Lin, T.-Y.; Shieh, J.-S.; Chen, Y.; Huang, N. E.; Wu, Z.; Peng, C.-K.

    2008-02-01

    In this investigation, surgical operations of blocked intestinal artery have been conducted on pigs to simulate the condition of acute mesenteric arterial occlusion. The empirical mode decomposition method and the algorithm of linguistic analysis were applied to verify the blood pressure signals in simulated situation. We assumed that there was some information hidden in the high-frequency part of the blood pressure signal when an intestinal artery is blocked. The empirical mode decomposition method (EMD) has been applied to decompose the intrinsic mode functions (IMF) from a complex time series. But, the end effects and phenomenon of intermittence damage the consistence of each IMF. Thus, we proposed the complementary ensemble empirical mode decomposition method (CEEMD) to solve the problems of end effects and the phenomenon of intermittence. The main wave of blood pressure signals can be reconstructed by the main components, identified by Monte Carlo verification, and removed from the original signal to derive a riding wave. Furthermore, the concept of linguistic analysis was applied to design the blocking index to verify the pattern of riding wave of blood pressure using the measurements of dissimilarity. Blocking index works well to identify the situation in which the sampled time series of blood pressure signal was recorded. Here, these two totally different algorithms are successfully integrated and the existence of the existence of information hidden in high-frequency part of blood pressure signal has been proven.

  11. Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells.

    Directory of Open Access Journals (Sweden)

    Renyue Bao

    Full Text Available Constitutive Wnt signalling is characterized by excessive levels of β-catenin protein and is a frequent occurrence in cancer. APC and Axin are key components of the β-catenin destruction complex that acts to promote β-catenin degradation. The levels of Axin are in turn controlled by tankyrases, members of the PARP-family of poly-ADP-ribosylation enzymes. In colorectal cancer cells, which typically harbor APC mutations, inhibition of tankyrase activity promotes Axin stabilization and attenuates Wnt signalling. Here, we examined the effect of inhibiting tankyrases in breast cancer cells with normal APC. We show that application of the small molecule tankyrase inhibitor, XAV939 or siRNA-mediated abrogation of tankyrase expression increases Axin1 and Axin2 protein levels and attenuates Wnt-induced transcriptional responses in several breast cancer lines. In MDA-MB-231 cells, inhibiton of tankyrase activity also attenuate Wnt3a induced cell migration. Moreover, in both MDA-MB-231 and colorectal cancer cells, XAV939 inhibits cell growth under conditions of serum-deprivation. However, the presence of serum prevents this growth inhibitory effect, although inhibition of Wnt-induced transcriptional and migratory responses was maintained. These results indicate that stabilization of Axin by inhibition of tankyrases alone, may not be an effective means to block tumor cell growth and that combinatorial therapeutic approaches should be considered.

  12. Multiprocessor schemes for solving block tridiagonal linear systems

    Energy Technology Data Exchange (ETDEWEB)

    Berry, M.W.; Sameh, A. (Univ. of Illinois at Urbana-Champaign, Urbana, IL (US))

    1988-01-01

    The solution of large, banded diagonally dominant or symmetric positive definite linear systems constitutes one of the most common computational tasks associated with implementations of the finite element method in applications such as fluid dynamics and structural analysis. Thus, designing multiprocessor algorithms for solving large block tridiagonal systems becomes of paramount importance for efficient implementation of these applications on vector and parallel machines. The authors present such schemes here, along with specific performance results on the Alliant FX/8 and CRAY X-MP 48. They particularly emphasize the speedups obtained with these schemes over popular direct band solvers. The development of a candidate scheme for the multicluster CEDAR machine is their goal.

  13. Iterative multi-user detection and decoding for space-time block coding systems

    Institute of Scientific and Technical Information of China (English)

    JIN Yi-dan; ZHANG Feng; WU Wei-ling

    2006-01-01

    To restrain the interference of co-channel users using space-time block coding (STBC), the proposed Gaussian-forcing soft decision multi-user detection (GFSDMUD) algorithm is applied in flat-fading channels by using the relation among the users' signals, which can enhance the capacity by introducing co-channel users. During iterations, extrinsic information is calculated and exchanged between a soft multi-user detector and a bank of turbo decoders to achieve refined estimates of the users' signals. The simulations show that the proposed iterative receiver techniques provide significant performance improvement around 2 dB over conventional noniterative methods. Furthermore, iterative multi-user space-time processing techniques offer substantial performance gains around 8 dB by adding the number of receiver antennas from 4to 6, and the system performance can be enhanced by using this strategy in multi-user STBC systems, which is very important for enlarging the system capacity.

  14. Kalkitoxin Inhibits Angiogenesis, Disrupts Cellular Hypoxic Signaling, and Blocks Mitochondrial Electron Transport in Tumor Cells

    Directory of Open Access Journals (Sweden)

    J. Brian Morgan

    2015-03-01

    Full Text Available The biologically active lipopeptide kalkitoxin was previously isolated from the marine cyanobacterium Moorea producens (Lyngbya majuscula. Kalkitoxin exhibited N-methyl-d-aspartate (NMDA-mediated neurotoxicity and acted as an inhibitory ligand for voltage-sensitive sodium channels in cultured rat cerebellar granule neurons. Subsequent studies revealed that kalkitoxin generated a delayed form of colon tumor cell cytotoxicity in 7-day clonogenic cell survival assays. Cell line- and exposure time-dependent cytostatic/cytotoxic effects were previously observed with mitochondria-targeted inhibitors of hypoxia-inducible factor-1 (HIF-1. The transcription factor HIF-1 functions as a key regulator of oxygen homeostasis. Therefore, we investigated the ability of kalkitoxin to inhibit hypoxic signaling in human tumor cell lines. Kalkitoxin potently and selectively inhibited hypoxia-induced activation of HIF-1 in T47D breast tumor cells (IC50 5.6 nM. Mechanistic studies revealed that kalkitoxin inhibits HIF-1 activation by suppressing mitochondrial oxygen consumption at electron transport chain (ETC complex I (NADH-ubiquinone oxidoreductase. Further studies indicate that kalkitoxin targets tumor angiogenesis by blocking the induction of angiogenic factors (i.e., VEGF in tumor cells.

  15. Oxethazaine inhibits hepatitis B virus capsid assembly by blocking the cytosolic calcium-signalling pathway.

    Science.gov (United States)

    Zhang, Lin; Liu, Chunlan; Xiao, Yu; Chen, Xulin

    2016-05-01

    Chronic hepatitis B virus (HBV) infection is a serious public health problem and may progress to liver fibrosis, cirrhosis and hepatocellular carcinoma. It is currently treated with PEGylated IFN-α2a and nucleoside/nucleotide analogues (NAs). However, PEGylated IFN treatment has problems of high cost, low efficiency and side effects. Long-term administration of NAs is necessary to avoid virus relapse, which can cause drug resistance and side effects. New efforts are now being directed to develop novel anti-HBV drugs targeting either additional viral targets other than viral DNA polymerase or host targets to improve the treatment of chronic hepatitis B. In this study, we discovered that oxethazaine, approved for clinic use in a few countries such as Japan, India, South Africa and Brazil, can dose-dependently reduce the levels of HBV envelope antigen, extracellular HBV DNA in supernatants and intracellular HBV total DNA. However, the levels of HBV cccDNA and HBV RNAs were not affected by oxethazaine treatment. Further study confirmed that oxethazaine acts on the virus assembly stage of the HBV life cycle. A study of the mechanisms of oxethazaine suggested that this drug inhibits HBV replication and capsid assembly by blocking the cytosolic calcium-signalling pathway. Moreover, oxethazaine could inhibit the replication of lamivudine/entecavir-dual-resistant and adefovir-resistant HBV mutants. In conclusion, our study suggests that oxethazaine may serve as a promising drug, or could be used as a starting point for anti-HBV drug discovery. PMID:26838678

  16. CYLD Inhibits Tumorigenesis and Metastasis by Blocking JNK/AP1 Signaling at Multiple Levels

    Science.gov (United States)

    de Marval, Paula Miliani; Lutfeali, Shazia; Jin, Jane Y.; Leshin, Benjamin; Selim, M. Angelica; Zhang, Jennifer Y.

    2011-01-01

    CYLD has been recognized as a tumor suppressor due to its dominant genetic linkage to multiple types of epidermal tumors and a range of other cancers. The molecular mechanisms governing CYLD control of skin cancer are still unclear. Here, we demonstrated that K14-driven epidermal expression of a patient relevant and catalytically deficient CYLD truncation mutant (CYLDm) sensitized mice to skin tumor development in response to DMBA/TPA-challenge. Tumors developed on transgenic mice were prone to malignant progression and lymph node metastasis, and displayed increased activation of JNK and the downstream c-Jun and c-Fos proteins. Most importantly, topical application of a pharmacological JNK inhibitor significantly reduced tumor development and abolished metastasis in the transgenic mice. Further in line with these animal data, exogenous expression of CYLDm in A431, a human squamous cell carcinoma (SCC) cell line, markedly enhanced cell growth, migration and subcutaneous tumor growth in an AP1-depdendent manner. In contrast, expression of the wild type CYLD inhibited SCC tumorigenesis and AP1 function. Most importantly, CYLDm not only increased JNK activation but also induced an upregulation of K63-ubiquitination on both c-Jun and c-Fos, leading to sustained AP1 activation. Our findings uncovered c-Jun and c-Fos as novel CYLD-targets and underscore that CYLD controls epidermal tumorigenesis through blocking the JNK/AP1 signaling pathway at multiple levels. PMID:21478324

  17. The IRS-1 signaling system.

    Science.gov (United States)

    White, M F

    1994-02-01

    IRS-1 is a principal substrate of the insulin receptor tyrosine kinase. It undergoes multi-site tyrosine phosphorylation and mediates the insulin signal by associating with various signaling molecules containing Src homology 2 domains. Interleukin-4 also stimulates IRS-1 phosphorylation, and it is suspected that a few more growth factors or cytokines will be added to form a select group of receptors that utilize the IRS-1 signaling pathway. More IRS-1-like adapter molecules, such as 4PS (IRS-2), may remain to be found.

  18. 76 FR 21943 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System

    Science.gov (United States)

    2011-04-19

    ...) seeks approval of the proposed discontinuance and removal of the automatic block signal system (ABS) on... Railroad Signal System Pursuant to Title 49 Code of Federal Regulations (CFR) Part 235 and 49 U.S.C. 20502... for the discontinuance or modification of the signal system, as detailed below. Docket Number...

  19. 77 FR 31429 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System

    Science.gov (United States)

    2012-05-25

    ... approval of the proposed discontinuance of an automatic block signal (ABS) system and a traffic control... Railroad Signal System In accordance with Part 235 of Title 49 Code of Federal Regulations (CFR) and 49 U.S...) seeking approval for the discontinuance or modification of a signal system. FRA assigned the...

  20. Signals and systems primer with Matlab

    CERN Document Server

    Poularikas, Alexander D

    2006-01-01

    Signals and Systems Primer with MATLAB® equally emphasizes the fundamentals of both analog and digital signals and systems. To ensure insight into the basic concepts and methods, the text presents a variety of examples that illustrate a wide range of applications, from microelectromechanical to worldwide communication systems. It also provides MATLAB functions and procedures for practice and verification of these concepts.Taking a pedagogical approach, the author builds a solid foundation in signal processing as well as analog and digital systems. The book first introduces orthogonal signals,

  1. The time keeping system for GPS block IIR

    Science.gov (United States)

    Rawicz, H. C.; Epstein, M. A.; Rajan, J. A.

    1993-01-01

    The precision time keeping system (TKS) in the Global Positioning System (GPS), Block IIR satellites is designed to operate under severe natural and man made environmental conditions. The Block IIR TKS provides precise, autonomous time keeping for periods of up to seven months, without the intervention of the GPS Control Segment. The TKS is implemented using both linear and non-linear controls. The resulting TKS architecture uses a hybrid analog/digital phase locked loop (PLL). The paper provides details of the design and analysis of the TKS. The simulation techniques and the test bed activities used in performing the TKS design trade-offs are described. The effects of non-linear controls are analyzed using a TKS computer simulation of the PLL. The results from a hardware test bed are provided that verify desired TKS operation. The design criteria for the TKS computer simulation and the hardware test bed are indicated. The concepts for verification and testing of the TKS computer simulation and hardware test bed are presented.

  2. The Blocks database--a system for protein classification.

    OpenAIRE

    Pietrokovski, S; Henikoff, J G; Henikoff, S.

    1996-01-01

    The Blocks Database contains multiple alignments of conserved regions in protein families. The database can be searched by e-mail and World Wide Web(WWW) servers (http://blocks.fhcrc.org/help) to classify protein and nucleotide sequences.

  3. Accuracy guaranties for $\\ell_1$ recovery of block-sparse signals

    OpenAIRE

    Juditsky, Anatoli; Karzan, Fatma Kılınç; Nemirovski, Arkadi; Polyak, Boris

    2011-01-01

    We introduce a general framework to handle structured models (sparse and block-sparse with possibly overlapping blocks). We discuss new methods for their recovery from incomplete observation, corrupted with deterministic and stochastic noise, using block-$\\ell_{1}$ regularization. While the current theory provides promising bounds for the recovery errors under a number of different, yet mostly hard to verify conditions, our emphasis is on verifiable conditions on the problem parameters (sensi...

  4. Rateless Space Time Block Code for Massive MIMO Systems

    Directory of Open Access Journals (Sweden)

    Ali H. Alqahtani

    2014-01-01

    Full Text Available This paper presents a rateless space time block code (RSTBC for massive MIMO systems. The paper illustrates the basis of rateless space time codes deployments in massive MIMO transmissions over wireless erasure channels. In such channels, data may be lost or is not decodable at the receiver due to a variety of factors such as channel fading, interference, or antenna element failure. We show that RSTBC guarantees the reliability of the system in such cases, even when the data loss rate is 25% or more. In such a highly lossy channel, the conventional fixed-rate codes fail to perform well, particularly when channel state information is not available at the transmitter. Simulation results are provided to demonstrate the BER performance and the spectral efficiency of the proposed scheme.

  5. Sonic hedgehog signaling during nervous system development

    Institute of Scientific and Technical Information of China (English)

    Qin Yang; Peng Xie

    2008-01-01

    The Hedgehog signaling pathway plays a key role in embryonic development and organ formation.Sonic hedgehog signaling participates in nervous system development,regulates proliferation and differentiation of neural stem cells,controls growth and targeting of axons,and contributes to specialization of oligodendrocytes.For further studies of the Sonic hedgehog signaling pathway and for the development of new drugs in the treatment of nervous system diseases,it is beneficial to understand these mechanisms.

  6. Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats

    Directory of Open Access Journals (Sweden)

    Yang Jia-Le

    2012-05-01

    Full Text Available Abstract Background Spinal glia, particularly microglia and astrocytes, are of the utmost importance in the development and maintenance of chronic pain. A recent study from our laboratory revealed that gabapentin, a recommended first-line treatment for multiple neuropathic conditions, could also efficiently antagonize thermal hyperalgesia evoked by complete Freund's adjuvant (CFA-induced monoarthritis (MA. In the present study, we investigated whether the spinal glia are involved in the anti-hyperalgesic effect of gabapentin and how this event occurs. Results Unilateral intra-articular injection of CFA produced a robust activation of microglia and astrocytes. These cells exhibited large cell bodies, thick processes and increases in the ionized calcium binding adapter molecule 1 (Iba-1, a microglial marker or the glia fibrillary acidic protein (GFAP, an astrocytic marker. These cells also displayed immunoreactive signals, and an upregulation of the voltage-gated calcium channels (VGCCs α2/δ-1 subunit, CX3CL1 and CX3CR1 expression levels in the spinal cord. These changes were associated with the development of thermal hyperalgesia. Immunofluorescence staining showed that VGCC α2/δ-1 subunit, a proposed gabapentin target of action, was widely distributed in primary afferent fibers terminals and dorsal horn neurons. CX3CL1, a potential trigger to activate microglia, colocalized with VGCC α2/δ-1 subunits in the spinal dorsal horn. However, its receptor CX3CR1 was mainly expressed in the spinal microglia. Multiple intraperitoneal (i.p. gabapentin injections (100 mg/kg, once daily for 4 days with the first injection 60 min before intra-articular CFA suppressed the activation of spinal microglia, downregulated spinal VGCC α2/δ-1 subunits decreased CX3CL1 levels and blocked the development of thermal hyperalgesia in MA rats. Conclusions Here we provide the first evidence that gabapentin diminishes CX3CL1 signaling and spinal microglia

  7. Properties of train traffic flow in a moving block system

    Institute of Scientific and Technical Information of China (English)

    Wang Min; Zeng Jun-Wei; Qian Yong-Sheng; Li Wen-Jun; Yang Fang; Jia Xin-Xin

    2012-01-01

    The development direction of railways is toward the improvement of capacity and service quality,where the service quality includes safety,schedule,high speed,and comfort.In light of the existing cellular automaton models,in this paper,we develop a model to analyze the mixed running processes of trains with maximal speeds of 500 km/h and 350 km/h respectively in the moving block system.In the proposed model,we establish some sound rules to control the running processes of a train,where the rules include the departure rules in the intermediate stations,the overtaking rules,and the conditions of speed limitation for a train stopping at a station or passing through a station.With the consideration of the mixed ratio and the distance between two adjacent stations,the properties of the train traffic flow (including capacity and average speed) are simulated.The numerical results show that the interactions among different trains will affect the capacity,and a proper increase of the spatial distance between two adjacent stations can enhance the capacity and the average speed under the moving block.

  8. Aerial multi-camera systems: Accuracy and block triangulation issues

    Science.gov (United States)

    Rupnik, Ewelina; Nex, Francesco; Toschi, Isabella; Remondino, Fabio

    2015-03-01

    Oblique photography has reached its maturity and has now been adopted for several applications. The number and variety of multi-camera oblique platforms available on the market is continuously growing. So far, few attempts have been made to study the influence of the additional cameras on the behaviour of the image block and comprehensive revisions to existing flight patterns are yet to be formulated. This paper looks into the precision and accuracy of 3D points triangulated from diverse multi-camera oblique platforms. Its coverage is divided into simulated and real case studies. Within the simulations, different imaging platform parameters and flight patterns are varied, reflecting both current market offerings and common flight practices. Attention is paid to the aspect of completeness in terms of dense matching algorithms and 3D city modelling - the most promising application of such systems. The experimental part demonstrates the behaviour of two oblique imaging platforms in real-world conditions. A number of Ground Control Point (GCP) configurations are adopted in order to point out the sensitivity of tested imaging networks and arising block deformations. To stress the contribution of slanted views, all scenarios are compared against a scenario in which exclusively nadir images are used for evaluation.

  9. Efficient spread space-time block coding scheme in multiple antenna systems

    Institute of Scientific and Technical Information of China (English)

    Qiu Ling; Zheng Xiayu

    2006-01-01

    Space-time coding is an important technique that can improve transmission performance at fading environments in mobile communication systems. In this paper, we propose a novel diversity scheme using spread spacetime block coding (SSTBC) in multiple antenna systems. At the transmitter, the primitive data are serial to parallel converted to multiple data streams, and each stream is rotated in constellation. Then Walsh codes are used to spread each symbol to all antenna space in a space-time block. The signals received from all receiver antennas are combined with the maximum ratio combining (MRC), equalized with linear equalizer to eliminate the inter-code interference and finally demodulated to recover to transmit data by using the one-symbol maximum likelihood detector. The proposed scheme does not sacrifice the spectrum efficiency meanwhile maintains the transceiver with low complexity. Owing to the transmission symbols of different transmit antennas passing through all the spatial subchannels between transceiver antenna pairs, the system obtains the partial additional space diversity gain of all spatial paths. It is also shown that the diversity gain is better than the previous space-time block coding (STBC) schemes with full transmission rate.

  10. INVERSE DDA OF A SYSTEM OF BLOCKS IN SPHERE COORDINATES

    Institute of Scientific and Technical Information of China (English)

    Wu Yun; Wang Hui; Zhou Shuoyu; Shi Shunying

    2003-01-01

    In accordance with the geometric equations of elastic-mechanics in the sphere-coordinates, the displacement equation of blocks on asphere consisting of 6 deforming parameters is developed, The formula for distance between blocks is derived under the supposition that all block boundaries are prime arcs. The kinematic constraint and the penalty function for reasonable contact between blocks are developed. The normal equations and their coefficient matrix, based on the Least Squares Principle, are derived. The problem of adjudging penetration between blocks is discussed, and a solution is proposed.

  11. INVERSE DDA OF A SYSTEM OF BLOCKS IN SPHERE COORDINATES

    Institute of Scientific and Technical Information of China (English)

    WuYun; WangHui; ZhouShuoyu; ShiShunying

    2003-01-01

    In accordance with the geometric equations of elastic-mechanics in the sphere-coordinates, the displacement equation of blocks on asphere consisting of 6 deforming parameters is developed. The formula for distance between blocks is derived under the supposition that all block boundaries are prime arcs. The kinematic constraint and the penalty function for reasonable contact between blocks are developed. The normal equations and their coefficient matrix, based on the Least Squares Principle, are derived. The problem of adjudging penetration between blocks is discussed, and a solution is proposed.

  12. Intelligent Multimodal Signal Adaptation System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Micro Analysis and Design (MA&D) is pleased to submit this proposal to design an Intelligent Multimodal Signal Adaptation System. This system will dynamically...

  13. Tectonic Setting and Metallogenic System of North China Block Margins

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    The paleocontinental margins have frequent and intensive tectonic movement and various ore-forming processes. According to their tectono-dynamic characteristics, the paleocontinental margins can be classified into three types: the divergent, the convergent and the transformational. Each type has its specific geological-geochemical processes and metallogenic system. The paper discusses thetectonic evolution and ore-forming features of the North China block margins, puts forward conceptions such as complexity, variety and multi-stage development of metallogenic evolution in the paleocontinental margins, and expounds five factors controlling the formation of large-superlarge ore deposits in the paleocontinental margins: (1) channelway, (2) rendezvous of fluids, (3) abundance of ore source, (4) thermo-dynamic anomaly, (5) long duration of structural activities.

  14. System for surveillance of spectral signals

    Science.gov (United States)

    Gross, Kenneth C.; Wegerich, Stephan W.; Criss-Puszkiewicz, Cynthia; Wilks, Alan D.

    2001-01-01

    A method and system for monitoring at least one of a system, a process and a data source. A method and system have been developed for carrying out surveillance, testing and modification of an ongoing process or other source of data, such as a spectroscopic examination. A signal from the system under surveillance is collected and compared with a reference signal, a frequency domain transformation carried out for the system signal and reference signal, a frequency domain difference function established. The process is then repeated until a full range of data is accumulated over the time domain and a SPRT sequential probability ratio test methodology applied to determine a three-dimensional surface plot characteristic of the operating state of the system under surveillance.

  15. A Parallel Framework with Block Matrices of a Discrete Fourier Transform for Vector-Valued Discrete-Time Signals

    Directory of Open Access Journals (Sweden)

    Pablo Soto-Quiros

    2015-01-01

    Full Text Available This paper presents a parallel implementation of a kind of discrete Fourier transform (DFT: the vector-valued DFT. The vector-valued DFT is a novel tool to analyze the spectra of vector-valued discrete-time signals. This parallel implementation is developed in terms of a mathematical framework with a set of block matrix operations. These block matrix operations contribute to analysis, design, and implementation of parallel algorithms in multicore processors. In this work, an implementation and experimental investigation of the mathematical framework are performed using MATLAB with the Parallel Computing Toolbox. We found that there is advantage to use multicore processors and a parallel computing environment to minimize the high execution time. Additionally, speedup increases when the number of logical processors and length of the signal increase.

  16. SYSTEM ANALYSIS OF DISCIPLINARY-BLOCK TRAINING PRINCIPLE

    OpenAIRE

    A. S. Mikhalev

    2014-01-01

    A traditional approach to organization of group-training method leads to rather sharp contra-dictions of «discreteness», «assortment» and «asynchronicity». A disciplinary-block training principle overcomes the indicated contradictions owing to breaking-up a term and a term disciplinary set in blocks, consecutive study of every block and distribution of examinations in «butt joints» between the blocks. The paper shows that the principle significantly improves important properties of education ...

  17. AMPK inhibition blocks ROS-NFκB signaling and attenuates endotoxemia-induced liver injury.

    Directory of Open Access Journals (Sweden)

    Yuan Guo

    Full Text Available BACKGROUND: AMP-activated protein kinase (AMPK is an important enzyme in regulation of cellular energy homeostasis. We have previously shown that AMPK activation by 5-aminoimidazole-4-carboxamide (AICAR results in suppression of immune responses, indicating the pivotal role of AMPK in immune regulation. However, the cellular mechanism underpinning AMPK inhibition on immune response remains largely to be elucidated. The study aimed to investigate the effects of AMPK inhibition on reactive oxygen species (ROS-nuclear factor κB (NFκB signaling and endotoxemia-induced liver injury. METHODOLOGY/PRINCIPAL FINDINGS: RAW 264.7 cells were pretreated with AMPK activator or inhibitor, followed by LPS challenge. In addition, LPS was injected intraperitoneally into mice to induce systemic inflammation. The parameters of liver injury and immune responses were determined, and survival of mice was monitored respectively. LPS challenge in RAW 264.7 cells resulted in AMPK activation which was then inhibited by compound C treatment. Both AMPK activation by AICAR or inhibition by compound C diminished LPS-induced ROS generation, inhibited phosphorylation of IKK, IκB, and NFκB p65, and consequently, decreased TNF production of RAW 264.7 cells. AICAR or compound C treatment decreased ALT, AST, and TNF levels in serum, reduced CD68 expression and MPO activity in liver tissue of mice with endotoxemia. Moreover, AICAR or compound C treatment improved survival of endotoxemic mice. CONCLUSIONS: AICAR or compound C treatment attenuates LPS-induced ROS-NFκB signaling, immune responses and liver injury. Strategies to activate or inhibit AMPK signaling may provide alternatives to the current clinical approaches to inhibit immune responses of endotoxemia.

  18. Capturing blocked-entrance binaural signals from open-entrance recordings

    DEFF Research Database (Denmark)

    Hammershøi, Dorte; Hoffmann, Pablo F.; Olesen, Søren Krarup;

    2008-01-01

    Binaural recordings enable us to capture all sound attributes including spatial information, room effect, and source characteristics in a given environment. It has been shown that blocked-entrance binaural recordings provide advantages over open-entrance recordings, primarily because the blocked-...... context. To this purpose, equalization filters are derived from the ratio between blocked and open ear canal transfer functions. Different transfer-function measuring techniques and inverse filtering methods are evaluated.......Binaural recordings enable us to capture all sound attributes including spatial information, room effect, and source characteristics in a given environment. It has been shown that blocked-entrance binaural recordings provide advantages over open-entrance recordings, primarily because the blocked......-entrance recordings is not influenced by the ear canal acoustics of the individual for which it is recorded. However, blocking the ear canal for recoding imposes an obvious disruption to normal hearing conditions, which may be unacceptable for applications in which binaural audio capturing is desired but without...

  19. Research on Portable Fatigue Signal Detection System

    Directory of Open Access Journals (Sweden)

    Bowen Li

    2013-07-01

    Full Text Available According to the characteristics of human pulse wave signals, the acquisition system acquisition system with excellent performance is designed, 16 bit MCU MSP430 with ultralow power is used to record, process and transmit the collected pulse wave signals. In order to make the hardware part satisfy acquisition requirements of pulse wave, the paper focuses on discussing composition, operating principle, analysis method and performance parameter of analog circuit. The software part makes use of the design tools of Matlab graphical user interface (GUI for designing pulse wave signal measurement system. The trial on intelligent fatigue test signal adopts relatively unique methods no matter in hardware circuit design or software algorithm process, which provides important and meaningful reference for objective and quantitative research on fatigue signal.

  20. Systems Biology Analysis of Heterocellular Signaling.

    Science.gov (United States)

    Tape, Christopher J

    2016-08-01

    Tissues comprise multiple heterotypic cell types (e.g., epithelial, mesenchymal, and immune cells). Communication between heterotypic cell types is essential for biological cohesion and is frequently dysregulated in disease. Despite the importance of heterocellular communication, most systems biology techniques do not report cell-specific signaling data from mixtures of cells. As a result, our existing perspective of cellular behavior under-represents the influence of heterocellular signaling. Recent technical advances now permit the resolution of systems-level cell-specific signaling data. This review discusses how new physical, spatial, and isotopic resolving methods are facilitating unique systems biology studies of heterocellular communication. PMID:27087613

  1. Design of a Real-time Signal Processing System for LIF Sensor

    Energy Technology Data Exchange (ETDEWEB)

    Zhao Xiande; Zheng Wengang; Dong Daming; Shen Changjun; Zhang Xin; Zhou Jianjun; Yan Hua; Wu Wenbiao, E-mail: zhengwg@nercita.org.cn [National Engineering Research Center for Information Technology in Agriculture, 100097 (China)

    2011-02-01

    Laser Induced Fluorescence (LIF) sensor is one of the most sensitive approaches available for a variety of analytical applications, such as determination of nitrogen content of plant leaves, detection of chlorophyll content in water, etal. As a core instrumental requirements of real time LIF sensor, signal processing system is used to store effective processing and identification algorithms in a short time. By analyzing the working principle of LIF sensor in detail, a novel platform of signal processing system used in LIF sensor is proposed in this paper. The design solutions and hardware architecture of the system are described in this paper, include Digital Signal Processor (DSP), data transmission block, and memory block. Several steps of signal processing methods are proposed, according to the characteristic of LIF sensor. At last, an application of using the signal processing system designed in this paper for measuring chlorophyll content in plant leaves is shown.

  2. Signal processing by the endosomal system.

    Science.gov (United States)

    Villaseñor, Roberto; Kalaidzidis, Yannis; Zerial, Marino

    2016-04-01

    Cells need to decode chemical or physical signals from their environment in order to make decisions on their fate. In the case of signalling receptors, ligand binding triggers a cascade of chemical reactions but also the internalization of the activated receptors in the endocytic pathway. Here, we highlight recent studies revealing a new role of the endosomal network in signal processing. The diversity of entry pathways and endosomal compartments is exploited to regulate the kinetics of receptor trafficking, and interactions with specific signalling adaptors and effectors. By governing the spatio-temporal distribution of signalling molecules, the endosomal system functions analogously to a digital-analogue computer that regulates the specificity and robustness of the signalling response.

  3. COMPLEMENT BLOCK CODING SCHEME FOR REDUCING PEAK-TO-AVERAGE POWER RATIO OF OFDM SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    Jiang Tao; Zhu Guangxi

    2004-01-01

    A new scheme termed as Complement Block Coding (CBC) technique is proposed to reduce the Peak-to-Average Power Ratio (PAPR) of OFDM signals. Utilizing the complement bits which are added to the original information bits,this method can effectively reduce the PAPR of OFDM systems with random frame size N and the coding rate R ≤ (N - k)/N, where kis a positive integer and k ≤ N/2. The performance results obtained with CBC are given and compared with that of some well known schemes, such as Simple Block Coding (SBC), Modified Simple Block Coding (MSBC) and Simple Odd Parity Code (SOPC) for the same purpose. The results show that, at the same coding rate 3/4, the CBC can achieve almost the same performance as SBC, MSBC, but with lower complexity, and that the same performance can be obtained with higher coding rate by using CBC. At the same coding rate (N - 1)/N, the PAPR reduction of CBC is almost the twice as that of SOPC when N ≥ 16. Further more, the PAPR reductions with coding rate (N - 1)/N are almost the same as that with coding rate less than (N - 1)/N,so the proposed scheme CBC is more suitable for the large frame size with high coding rate and can provide error detection.

  4. A novel power swing blocking scheme using adaptive neuro-fuzzy inference system

    Energy Technology Data Exchange (ETDEWEB)

    Zadeh, Hassan Khorashadi; Li, Zuyi [Illinois Institute of Technology, Department of Electrical and Computer Engineering, 3301 S. Dearborn Street, Chicago, IL 60616 (United States)

    2008-07-15

    A power swing may be caused by any sudden change in the configuration or the loading of an electrical network. During a power swing, the impedance locus moves along an impedance circle with possible encroachment into the distance relay zone, which may cause an unnecessary tripping. In order to prevent the distance relay from tripping under such condition, a novel power swing blocking (PSB) scheme is proposed in this paper. The proposed scheme uses an adaptive neuro-fuzzy inference systems (ANFIS) for preventing distance relay from tripping during power swings. The input signals to ANFIS, include the change of positive sequence impedance, positive and negative sequence currents, and power swing center voltage. Extensive tests show that the proposed PSB has two distinct features that are advantageous over existing schemes. The first is that the proposed scheme is able to detect various kinds of power swings thus block distance relays during power swings, even if the power swings are fast or the power swings occur during single pole open conditions. The second distinct feature is that the proposed scheme is able to clear the blocking if faults occur within the relay trip zone during power swings, even if the faults are high resistance faults, or the faults occur at the power swing center, or the faults occur when the power angle is close to 180 . (author)

  5. A Method for Solving Cyclic Block Penta-diagonal Systems of Linear Equations

    OpenAIRE

    Batista, Milan

    2008-01-01

    A method for solving cyclic block three-diagonal systems of equations is generalized for solving a block cyclic penta-diagonal system of equations. Introducing a special form of two new variables the original system is split into three block pentagonal systems, which can be solved by the known methods. As such method belongs to class of direct methods without pivoting. Implementation of the algorithm is discussed in some details and the numerical examples are present.

  6. Interfering effect of noise on signaling systems

    Directory of Open Access Journals (Sweden)

    S.V. Chandrashekhar Rao

    1958-07-01

    Full Text Available Noise is statistical phenomenon. It has a complex wave form. This wave from may undergo modifications in the process of transmission of noise through a signaling system. The interfering effect of noise is always with specific reference to the type of signal that the system handles. Therefore, engineering evaluations of noise interference are more complex than the actual physical problem of noise.

  7. Child Abuse Images and Cleanfeeds: Assessing Internet Blocking Systems

    OpenAIRE

    McIntyre, T. J.

    2013-01-01

    One of the most important trends in internet governance in recent years has been the growth of internet blocking as a policy tool, to the point where it is increasingly becoming a global norm. This is most obvious in states such as China where blocking is used to suppress political speech; however, in the last decade blocking has also become more common in democracies, usually as part of attempts to limit the availability of child abuse images. Numerous governments have therefore settled on b...

  8. Cooperative storage of shared files in a parallel computing system with dynamic block size

    Science.gov (United States)

    Bent, John M.; Faibish, Sorin; Grider, Gary

    2015-11-10

    Improved techniques are provided for parallel writing of data to a shared object in a parallel computing system. A method is provided for storing data generated by a plurality of parallel processes to a shared object in a parallel computing system. The method is performed by at least one of the processes and comprises: dynamically determining a block size for storing the data; exchanging a determined amount of the data with at least one additional process to achieve a block of the data having the dynamically determined block size; and writing the block of the data having the dynamically determined block size to a file system. The determined block size comprises, e.g., a total amount of the data to be stored divided by the number of parallel processes. The file system comprises, for example, a log structured virtual parallel file system, such as a Parallel Log-Structured File System (PLFS).

  9. POTENSI MAHASISWA REGULAR BLOCK SYSTEM (RBS UNIVERSITAS KANJURUHAN MALANG

    Directory of Open Access Journals (Sweden)

    R. Anastasia Endang Susilawati

    2008-02-01

    Full Text Available Survey conducted to obtain get situation of quadran strategy determine elegibility of increase of maximum expense lecturing of program student of Regular Block System (RBS at institute education of University of Kanjuruhan Unlucky enlisting and active in year of akademic 2006/2007. Used variables shall be as follows: 1 psicografis, 2 social of demography and economics, 3 geografis, 4 benefit, 5 last experience, 6 physical medium, 7 expense, 8 advertisement, 9 word of mouth communication, 10 image of PTS, 11 quality of technical service, 12 quality of functional service, 13 satisfaction of student, and 14 student expectation. Technique data collecting use quesioner which consist of question closed and is open. Obtained to be data to be analysed to descriptive method and SWOT ( strengths, weaknesses, opportunities, threats. Result of survey indicate that University of Kanjuruhan unlucky reside in aggresive strategy ( strength 71.12% and opportunity 71.1% and also strategy diversify ( strength 71.12% and threat 69.8%, hence competent to boost up the expense of maximum study equal to 19.41% made balance to with diversification of program to overcome threats faced in this time and in the future.

  10. The response of high-impact blocking weather systems to climate change

    Science.gov (United States)

    Kennedy, Daniel; Parker, Tess; Woollings, Tim; Harvey, Benjamin; Shaffrey, Len

    2016-07-01

    Midlatitude weather and climate are dominated by the jet streams and associated eastward moving storm systems. Occasionally, however, these are blocked by persistent anticyclonic regimes known as blocking. Climate models generally predict a small decline in blocking frequency under anthropogenic climate change. However, confidence in these predictions is undermined by, among other things, a lack of understanding of the physical mechanisms underlying the change. Here we analyze blocking (mostly in the Euro-Atlantic sector) in a set of sensitivity experiments to determine the effect of different parts of the surface global warming pattern. We also analyze projected changes in the impacts of blocking such as temperature extremes. The results show that enhanced warming both in the tropics and over the Arctic act to strengthen the projected decline in blocking. The tropical changes are more important for the uncertainty in projected blocking changes, though the Arctic also affects the temperature anomalies during blocking.

  11. Block quasi-minimal residual iterations for non-Hermitian linear systems

    Energy Technology Data Exchange (ETDEWEB)

    Freund, R.W. [AT& T Bell Labs., Murray Hill, NJ (United States)

    1994-12-31

    Many applications require the solution of multiple linear systems that have the same coefficient matrix, but differ only in their right-hand sides. Instead of applying an iterative method to each of these systems individually, it is usually more efficient to employ a block version of the method that generates blocks of iterates for all the systems simultaneously. An example of such an iteration is the block conjugate gradient algorithm, which was first studied by Underwood and O`Leary. On parallel architectures, block versions of conjugate gradient-type methods are attractive even for the solution of single linear systems, since they have fewer synchronization points than the standard versions of these algorithms. In this talk, the author presents a block version of Freund and Nachtigal`s quasi-minimal residual (QMR) method for the iterative solution of non-Hermitian linear systems. He describes two different implementations of the block-QMR method, one based on a block version of the three-term Lanczos algorithm and one based on coupled two-term block recurrences. In both cases, the underlying block-Lanczos process still allows arbitrary normalizations of the vectors within each block, and the author discusses different normalization strategies. To maintain linear independence within each block, it is usually necessary to reduce the block size in the course of the iteration, and the author describes a deflation technique for performing this reduction. He also present some convergence results, and reports results of numerical experiments with the block-QMR method. Finally, the author discusses possible block versions of transpose-free Lanczos-based iterations such as the TFQMR method.

  12. Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways.

    Science.gov (United States)

    Zhang, Jing; Liu, Yangang; Beard, Caroline; Tuveson, David A; Jaenisch, Rudolf; Jacks, Tyler E; Lodish, Harvey F

    2007-06-15

    When overexpressed in primary erythroid progenitors, oncogenic Ras leads to the constitutive activation of its downstream signaling pathways, severe block of terminal erythroid differentiation, and cytokine-independent growth of primary erythroid progenitors. However, whether high-level expression of oncogenic Ras is required for these phenotypes is unknown. To address this issue, we expressed oncogenic K-ras (K-ras(G12D)) from its endogenous promoter using a tetracycline-inducible system. We show that endogenous K-ras(G12D) leads to a partial block of terminal erythroid differentiation in vivo. In contrast to results obtained when oncogenic Ras was overexpressed from retroviral vectors, endogenous levels of K-ras(G12D) fail to constitutively activate but rather hyperactivate cytokine-dependent signaling pathways, including Stat5, Akt, and p44/42 MAPK, in primary erythroid progenitors. This explains previous observations that hematopoietic progenitors expressing endogenous K-ras(G12D) display hypersensitivity to cytokine stimulation in various colony assays. Our results support efforts to modulate Ras signaling for treating hematopoietic malignancies.

  13. The Ubiquitin System and Jasmonate Signaling

    Directory of Open Access Journals (Sweden)

    Astrid Nagels Durand

    2016-01-01

    Full Text Available The ubiquitin (Ub system is involved in most, if not all, biological processes in eukaryotes. The major specificity determinants of this system are the E3 ligases, which bind and ubiquitinate specific sets of proteins and are thereby responsible for target recruitment to the proteasome or other cellular processing machineries. The Ub system contributes to the regulation of the production, perception and signal transduction of plant hormones. Jasmonic acid (JA and its derivatives, known as jasmonates (JAs, act as signaling compounds regulating plant development and plant responses to various biotic and abiotic stress conditions. We provide here an overview of the current understanding of the Ub system involved in JA signaling.

  14. Small signal gain in DPAL systems

    Science.gov (United States)

    Galbally-Kinney, Kristin L.; Maser, Daniel L.; Kessler, William J.; Rawlins, Wilson T.; Davis, Steven J.

    2011-03-01

    In this paper we describe a platform for small signal gain measurements for alkali atom laser systems based on the DPAL excitation method. We present initial results that clearly show the transition from absorption on the alkali atom D1 lines in Cs and Rb to optical transparency and positive gain. The achievement of optical gain is critically dependent upon alkali cell conditions and collision partners. We also present the first spatially resolved gain measurements in a DPAL system. The small signal gain methods described will be valuable tools for power scaling of these laser systems.

  15. Prediction of Wintertime Northern Hemisphere Blocking by the NCEP Climate Forecast System

    Institute of Scientific and Technical Information of China (English)

    JIA Xiaolong; YANG Song; SONG Wenling; HE Bin

    2014-01-01

    Daily output from the hindcasts by the NCEP Climate Forecast System version 2 (CFSv2) is analyzed to understand CFSv2’s skill in forecasting wintertime atmospheric blocking in the Northern Hemisphere. Prediction skills of sector blocking, sector-blocking episodes, and blocking onset/decay are assessed with a focus on the Euro-Atlantic sector (20◦W-45◦E) and the Pacifi c sector (160◦E-135◦W). Features of associated circulation and climate patterns are also examined. The CFSv2 well captures the observed features of longitudinal distribution of blocking activity, but underestimates blocking frequency and intensity and shows a decreasing trend in blocking frequency with increasing forecast lead time. Within 14-day lead time, the Euro-Atlantic sector blocking receives a higher skill than the Pacifi c sector blocking. Skillful forecast (taking the hit rate of 50% as a criterion) can be obtained up to 9 days in the Euro-Atlantic sector, which is slightly longer than that in the Pacifi c sector (7 days). The forecast skill of sector-blocking episodes is slightly lower than that of sector blocking in both sectors, and it is slightly higher in the Euro-Atlantic sector than in the Pacifi c sector. Compared to block onset, the skill for block decay is lower in the Euro-Atlantic sector, slightly higher in the Pacifi c sector during the early three days but lower after three days in lead time. In both the Euro-Atlantic and the Pacifi c sectors, a local dipole pattern in 500-hPa geopotential height associated with blocking is well presented in the CFSv2 prediction, but the wave-train like pattern that is far away from the blocking sector can only maintain in the forecast of relative short lead time. The CFSv2 well reproduces the observed characteristics of local temperature and precipitation anomalies associated with blocking.

  16. Analysis of Crown Block Weighing System%天车称重系统解析

    Institute of Scientific and Technical Information of China (English)

    王钰捷

    2012-01-01

    The hardware architecture, working principle, transmission mode, instrument fimction, weighing sensor princi- ple, wire rope supplement and correction, signal transmission,weighing instruments of crown block weighing system are intro- duced using the example of 240t crown block weighing system of steel making and rolling plant of Hebei Tangshan Iron & Steel Co., LTD. Combing with practical operation in production, the common problems in maintenance are summarized and the solutions are given.%以河北钢铁集团唐山钢铁有限责任公司一钢轧厂240t天车称重系统为例,介绍天车称重系统的硬件结构、工作原理、传输方式、仪表功能、称重传感器原理、钢丝绳补偿、信号传输、称重仪表等,结合在生产中的实际运行状况,总结出在生产维护中的常见问题,并提出具体的解决方法。

  17. Signaling via the NFκB system.

    Science.gov (United States)

    Mitchell, Simon; Vargas, Jesse; Hoffmann, Alexander

    2016-05-01

    The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune development, immune responses, inflammation, and cancer. The NFκB signaling system (defined by the interactions between NFκB dimers, IκB regulators, and IKK complexes) is responsive to a number of stimuli, and upon ligand-receptor engagement, distinct cellular outcomes, appropriate to the specific signal received, are set into motion. After almost three decades of study, many signaling mechanisms are well understood, rendering them amenable to mathematical modeling, which can reveal deeper insights about the regulatory design principles. While other reviews have focused on upstream, receptor proximal signaling (Hayden MS, Ghosh S. Signaling to NF-κB. Genes Dev 2004, 18:2195-2224; Verstrepen L, Bekaert T, Chau TL, Tavernier J, Chariot A, Beyaert R. TLR-4, IL-1R and TNF-R signaling to NF-κB: variations on a common theme. Cell Mol Life Sci 2008, 65:2964-2978), and advances through computational modeling (Basak S, Behar M, Hoffmann A. Lessons from mathematically modeling the NF-κB pathway. Immunol Rev 2012, 246:221-238; Williams R, Timmis J, Qwarnstrom E. Computational models of the NF-KB signalling pathway. Computation 2014, 2:131), in this review we aim to summarize the current understanding of the NFκB signaling system itself, the molecular mechanisms, and systems properties that are key to its diverse biological functions, and we discuss remaining questions in the field. WIREs Syst Biol Med 2016, 8:227-241. doi: 10.1002/wsbm.1331 For further resources related to this article, please visit the WIREs website. PMID:26990581

  18. Traffic Signal Using Smart Agent System

    Directory of Open Access Journals (Sweden)

    Cheonshik Kim

    2008-01-01

    Full Text Available In this research, we propose an electro-sensitive traffic light using the smart agent algorithm to reduce traffic congestion and traffic accidents. The multi-agent system approach can provide a new and preferable solution. The proposed method adaptively controls the cycle of traffic signals even though the traffic volume varies. Consequently, we reduce the car waiting time and start-up delay time using fuzzy control of feedback data. In particular, we have designed and implemented a system to create optimum traffic signals in congested conditions. The effectiveness of this method was shown through simulation of multiple intersections.

  19. The V protein of Tioman virus is incapable of blocking type I interferon signaling in human cells.

    Directory of Open Access Journals (Sweden)

    Grégory Caignard

    Full Text Available The capacity of a virus to cross species barriers is determined by the development of bona fide interactions with cellular components of new hosts, and in particular its ability to block IFN-α/β antiviral signaling. Tioman virus (TioV, a close relative of mumps virus (MuV, has been isolated in giant fruit bats in Southeast Asia. Nipah and Hendra viruses, which are present in the same bat colonies, are highly pathogenic in human. Despite serological evidences of close contacts between TioV and human populations, whether TioV is associated to some human pathology remains undetermined. Here we show that in contrast to the V protein of MuV, the V protein of TioV (TioV-V hardly interacts with human STAT2, does not degrade STAT1, and cannot block IFN-α/β signaling in human cells. In contrast, TioV-V properly binds to human STAT3 and MDA5, and thus interferes with IL-6 signaling and IFN-β promoter induction in human cells. Because STAT2 binding was previously identified as a host restriction factor for some Paramyxoviridae, we established STAT2 sequence from giant fruit bats, and binding to TioV-V was tested. Surprisingly, TioV-V interaction with STAT2 from giant fruit bats is also extremely weak and barely detectable. Altogether, our observations question the capacity of TioV to appropriately control IFN-α/β signaling in both human and giant fruit bats that are considered as its natural host.

  20. 75 FR 5638 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System...

    Science.gov (United States)

    2010-02-03

    ... discontinuance and removal of the Automatic Block Signal System (ABS) on the entire railroad line between, but... the Federal Register published on April 11, 2000 (65 FR 19477) or at http://www.dot.gov/privacy.html... Railroad Signal System or Relief From the Requirements of Title 49 Code of Federal Regulations Part...

  1. Power systems signal processing for smart grids

    CERN Document Server

    Ribeiro, Paulo Fernando; Ribeiro, Paulo Márcio; Cerqueira, Augusto Santiago

    2013-01-01

    With special relation to smart grids, this book provides clear and comprehensive explanation of how Digital Signal Processing (DSP) and Computational Intelligence (CI) techniques can be applied to solve problems in the power system. Its unique coverage bridges the gap between DSP, electrical power and energy engineering systems, showing many different techniques applied to typical and expected system conditions with practical power system examples. Surveying all recent advances on DSP for power systems, this book enables engineers and researchers to understand the current state of the art a

  2. Bidirectional coupling of splicing and ATM signaling in response to transcription-blocking DNA damage

    NARCIS (Netherlands)

    M. Tresini (Maria); J.A. Marteijn (Jurgen); W. Vermeulen (Wim)

    2016-01-01

    textabstractIn response to DNA damage cells activate intricate protein networks to ensure genomic fidelity and tissue homeostasis. DNA damage response signaling pathways coordinate these networks and determine cellular fates, in part, by modulating RNA metabolism. Here we discuss a replication-indep

  3. Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.

    Science.gov (United States)

    Lerner, E C; Qian, Y; Blaskovich, M A; Fossum, R D; Vogt, A; Sun, J; Cox, A D; Der, C J; Hamilton, A D; Sebti, S M

    1995-11-10

    Ras-induced malignant transformation requires Ras farnesylation, a lipid posttranslational modification catalyzed by farnesyltransferase (FTase). Inhibitors of this enzyme have been shown to block Ras-dependent transformation, but the mechanism by which this occurs remains largely unknown. We have designed FTI-276, a peptide mimetic of the COOH-terminal Cys-Val-Ile-Met of K-Ras4B that inhibited potently FTase in vitro (IC50 = 500 pM) and was highly selective for FTase over geranylgeranyltransferase I (GGTase I) (IC50 = 50 nM). FTI-277, the methyl ester derivative of FTI-276, was extremely potent (IC50 = 100 nM) at inhibiting H-Ras, but not the geranylgeranylated Rap1A processing in whole cells. Treatment of H-Ras oncogene-transformed NIH 3T3 cells with FTI-277 blocked recruitment to the plasma membrane and subsequent activation of the serine/threonine kinase c-Raf-1 in cells transformed by farnesylated Ras (H-RasF), but not geranylgeranylated, Ras (H-RasGG). FTI-277 induced accumulation of cytoplasmic non-farnesylated H-Ras that was able to bind Raf and form cytoplasmic Ras/Raf complexes in which Raf kinase was not activated. Furthermore, FTI-277 blocked constitutive activation of mitogen-activated protein kinase (MAPK) in H-RasF, but not H-RasGG, or Raf-transformed cells. FTI-277 also inhibited oncogenic K-Ras4B processing and constitutive activation of MAPK, but the concentrations required were 100-fold higher than those needed for H-Ras inhibition. The results demonstrate that FTI-277 blocks Ras oncogenic signaling by accumulating inactive Ras/Raf complexes in the cytoplasm, hence preventing constitutive activation of the MAPK cascade.

  4. Block Two-stage Methods for Singular Systems and Markov Chains

    OpenAIRE

    Migallón Gomis, Violeta; Penadés, Jose; Szyld, Daniel B.

    2007-01-01

    Research Report 95-121, Department of Mathematics, Temple University, December 1995. This paper appeared, in revised form, in Numerical Linear Algebra with Applications, vol. 3 (1996) 413-426. The use of block two-stage methods for the iterative solution of consistent singular linear systems is studied. In particular, hypotheses are provided for the convergence of non-stationary methods, i.e., when the number of inner iterations may vary from block to block and from one outer iteration to ...

  5. DESIGN PRINCIPLES AND BLOCK SCHEMES OF THE PROBE AUTOMATIC INSPECTION SYSTEMS FOR MICROAND NANOELECTRONICS ON A WAFER

    Directory of Open Access Journals (Sweden)

    V. A. Minchenko

    2012-01-01

    Full Text Available In this work we suggested the principles of design and block schemes of probe systems for analytical and interoperation measurement and inspection of high-speed microand nano on a chip systems in the nanosecond range. The sources of wideband signals distortion and errors of probe inspection systems for large integrated circuits inspection as well as transient response of high speed contacting probes are considered with the OTDR device with picosecond resolution. The features and defined errors of precision positioners for linear stepper motors and magnetic air motors for precise positioning of the probes on the pads with automatic sensing of LSI wafer are discussed. 

  6. Flash memory management system and method utilizing multiple block list windows

    Science.gov (United States)

    Chow, James (Inventor); Gender, Thomas K. (Inventor)

    2005-01-01

    The present invention provides a flash memory management system and method with increased performance. The flash memory management system provides the ability to efficiently manage and allocate flash memory use in a way that improves reliability and longevity, while maintaining good performance levels. The flash memory management system includes a free block mechanism, a disk maintenance mechanism, and a bad block detection mechanism. The free block mechanism provides efficient sorting of free blocks to facilitate selecting low use blocks for writing. The disk maintenance mechanism provides for the ability to efficiently clean flash memory blocks during processor idle times. The bad block detection mechanism provides the ability to better detect when a block of flash memory is likely to go bad. The flash status mechanism stores information in fast access memory that describes the content and status of the data in the flash disk. The new bank detection mechanism provides the ability to automatically detect when new banks of flash memory are added to the system. Together, these mechanisms provide a flash memory management system that can improve the operational efficiency of systems that utilize flash memory.

  7. Haptic teleoperation systems signal processing perspective

    CERN Document Server

    Lee, Jae-young

    2015-01-01

    This book examines the signal processing perspective in haptic teleoperation systems. This text covers the topics of prediction, estimation, architecture, data compression, and error correction that can be applied to haptic teleoperation systems. The authors begin with an overview of haptic teleoperation systems, then look at a Bayesian approach to haptic teleoperation systems. They move onto a discussion of haptic data compression, haptic data digitization and forward error correction.   ·         Presents haptic data prediction/estimation methods that compensate for unreliable networks   ·         Discusses haptic data compression that reduces haptic data size over limited network bandwidth and haptic data error correction that compensate for packet loss problem   ·         Provides signal processing techniques used with existing control architectures.

  8. Traffic Signal Using Smart Agent System

    OpenAIRE

    Cheonshik Kim; You S. Hong

    2008-01-01

    In this research, we propose an electro-sensitive traffic light using the smart agent algorithm to reduce traffic congestion and traffic accidents. The multi-agent system approach can provide a new and preferable solution. The proposed method adaptively controls the cycle of traffic signals even though the traffic volume varies. Consequently, we reduce the car waiting time and start-up delay time using fuzzy control of feedback data. In particular, we have designed and implemented a system to...

  9. Dealing naturally with stumbling blocks on highways and byways of TRAIL induced signaling.

    Science.gov (United States)

    Rana, Aamir; Attar, Rukset; Qureshi, Muhammad Zahid; Gasparri, Maria Luisa; Donato, Violante Di; Ali, Ghulam Muhammad; Farooqi, Ammad Ahmad

    2014-01-01

    In-depth analysis of how TRAIL signals through death receptors to induce apoptosis in cancer cells using high throughput technologies has added new layers of knowledge. However, the wealth of information has also highlighted the fact that TRAIL induced apoptosis may be impaired as evidenced by experimental findings obtained from TRAIL resistant cancer cell lines. Overwhelmingly, increasing understanding of TRAIL mediated apoptosis has helped in identifying synthetic and natural compounds which can restore TRAIL induced apoptosis via functionalization of either extrinsic or intrinsic pathways. Increasingly it is being realized that biologically active phytochemicals modulate TRAIL induced apoptosis, as evidenced by cell-based studies. In this review we have attempted to provide an overview of how different phytonutrients have shown efficacy in restoring apoptosis in TRAIL resistant cancer cells. We partition this review into how the TRAIL mediated signaling landscape has broadened over the years and how TRAIL induced signaling machinery crosstalks with autophagic protein networks. Subsequently, we provide a generalized view of considerable biological activity of coumarins against a wide range of cancer cell lines and how coumarins (psoralidin and esculetin) isolated from natural sources have improved TRAIL induced apoptosis in resistant cancer cells. We summarize recent updates on piperlongumine, phenethyl isothiocyanate and luteolin induced activation of TRAIL mediated apoptosis. The data obtained from pre-clinical studies will be helpful in translation of information from benchtop to the bedside. PMID:25338981

  10. Drugs to block cytokine signaling for the prevention and treatment of inflammation induced preterm birth

    Directory of Open Access Journals (Sweden)

    Pearl Y Ng

    2015-04-01

    Full Text Available Preterm birth (PTB at less than 37 weeks of gestation is the leading cause of neonatal morbidity and mortality. Intrauterine infection (IUI due to microbial invasion of the amniotic cavity is the leading cause of early PTB (<32 weeks. Commensal genital tract Ureaplasma and Mycoplasma species, as well as Gram-positive and Gram-negative bacteria, have been associated with IUI-induced PTB. Bacterial activation of toll-like receptors (TLRs and other pattern recognition receptors initiates a cascade of inflammatory signaling via the NF-κB and p38 MAPK signaling pathways, prematurely activating parturition. Antenatal antibiotic treatment has had limited success in preventing PTB or fetal inflammation. Administration of anti-inflammatory drugs with antibiotics could be a viable therapeutic option to prevent PTB and fetal complications in women at risk of IUI and inflammation. In this mini-review we will discuss the potential for anti-inflammatory drugs in obstetric care, focusing on the class of drugs termed ‘cytokine suppressive anti-inflammatory drugs’ or CSAIDs. These inhibitors work by specifically targeting the NF-κB and p38 MAPK inflammatory signaling pathways. Several CSAIDs are discussed, together with clinical and toxicological considerations associated with the administration of anti-inflammatory agents in pregnancy.

  11. Spatial Organization of Cytokinesis Signaling Reconstituted in a Cell-Free System*

    OpenAIRE

    Nguyen, Phuong A.; Groen, Aaron C.; Loose, Martin; Ishihara, Keisuke; Wühr, Martin; Field, Christine M.; Mitchison, Timothy J.

    2014-01-01

    During animal cell division, the cleavage furrow is positioned by microtubules that signal to the actin cortex at the cell midplane. We developed a cell-free system to recapitulate cytokinesis signaling using cytoplasmic extract from Xenopus eggs. Microtubules grew out as asters from artificial centrosomes and met to organize antiparallel overlap zones. These zones blocked interpenetration of neighboring asters and recruited cytokinesis midzone proteins including the Chromosoma...

  12. Antenna Array Signal Processing for Quaternion-Valued Wireless Communication Systems

    OpenAIRE

    Liu, W.

    2015-01-01

    Quaternion-valued wireless communication systems have been studied in the past. Although progress has been made in this promising area, a crucial missing link is lack of effective and efficient quaternion-valued signal processing algorithms for channel equalisation and beamforming. With most recent developments in quaternion-valued signal processing, in this work, we fill the gap to solve the problem and further derive the quaternion-valued Wiener solution for block-based calculation.

  13. PRECISE SYNTHESIS OF OLEFIN BLOCK COPOLYMERS USING A SYNDIOSPECIFIC LIVING POLYMERIZATION SYSTEM

    Institute of Scientific and Technical Information of China (English)

    Zheng-guo Cai; Hai-hui Su; Takeshi Shiono

    2013-01-01

    This feature article summarizes the synthesis of novel olefin block copolymers using fast syndiospecific living homo-and copolymerization of propylene,higher 1-alkene,and norbomene with ansa-fluorenylamidodimethyltitaniumbased catalyst according to the authors' recent results.The catalytic synthesis of monodisperse polyolefin and olefin block copolymer was also described using this living system.

  14. Joint impact of quantization and clipping on single- and multi-carrier block transmission systems

    NARCIS (Netherlands)

    Yang, H.; Schenk, T.C.W.; Smulders, P.F.M.; Fledderus, E.R.

    2008-01-01

    This work investigates the joint impact of quantization and clipping, caused by analog-to-digital converters (ADCs) with low bit resolutions, on single- and multi-carrier block transmission systems in wireless multipath environments. We consider single carrier block transmission with frequency domai

  15. Norcantharidin blocks Wnt/β-catenin signaling via promoter demethylation of WIF-1 in glioma.

    Science.gov (United States)

    Xie, Dajiang; Xie, Jixi; Wan, Yingfeng; Ma, Li; Qi, Xuchen; Wang, Kun; Yang, Shuxu

    2016-04-01

    Glioma is one of the most common primary intracranial tumors, and the prognosis is poor even though much treatment management is employed. Wnt/β-catenin signaling has been reported to be associated with glioma. Norcantharidin (NCTD) is the demethylated analog of cantharidin isolated from blister beetles, and it is reported to possess anticancer activity but less nephrotoxicity than cantharidin. Accordingly, we aimed to investigate NCTD as an anti-neoplastic drug that inhibits the Wnt/β‑catenin pathway via promoter demethylation of Wnt inhibitory factor-1 (WIF-1) in glioma growth in vitro. In the present study, we report that NCTD inhibited cell proliferation, induced apoptosis and cell cycle arrest, and suppressed cell migration and invasion in vitro. Moreover, we observed that the expression levels of WIF-1 mRNA and protein in the NCTD-treated cells were increased significantly compared with these levels in the negative control (NC) cells. Promoter demethylation was observed in the NCTD‑treated cells. In contrast, aberrant methylation was observed in the NC cells. Additionally, more investigation revealed that NCTD suppressed activity of Wnt/β-catenin signaling and transcription of β-catenin/TCF-4. Furthermore, the expression of apoptosis-related proteins Bcl-2 and cleaved caspase-3 indicated significant cell apoptosis. We provide initial evidence that NCTD reactivates WIF-1 from a methylation state, and downregulates canonical Wnt/β-catenin signaling. Our findings revealed that NCTD is effective for glioma in vitro and may be a new therapeutic option in vivo. PMID:26781164

  16. Blocking lhh Signaling Pathway Inhibits the Proliferation and Pro-motes the Apoptosis of PSCs

    Institute of Scientific and Technical Information of China (English)

    Kai XU; Fengjing GUO; Shuwei ZHANG; Cheng LIU; Feixiong WANG; Zhiguo ZHOU; Anmin CHEN

    2009-01-01

    The roles of Indian hedgehog (Ihh) signaling pathway in the proliferation and apoptosis of precartilaginous stem cells (PSCs) were investigated.PSCs,labeled with fibroblast growth factor receptor 3 (FGFR-3),were isolated from neonatal rats by immanomagnetic separation.After identifi-cation with FGFR-3 and Col Ⅱ,the cells were incubated with different concentrations of cyclopamine (cyclo),the specific inhibitor of lhh signaling pathway.The morphologic changes of the cells were observed under the inverted phase contrast microscope.The mRNA expression levels of Ibh,para-thyroid hormonerelated peptide (PTHrP),protein Patched (Ptch),Bcl-2 and p21 were detected by RT-PCR.The protein expression levels of Ihh and Ptch were measured by Western blot.MTT assay was used to examine the effects of cyclo on proliferation of PSCs.Apoptosis rate of PSCs was exam-ined by Annexin V/PI assay of flow cytometric analyses.After PSCs were incubated with cyclo,ob-vious morphologic changes were observed as compared with the control group.The mRNA expres-sion levels of PTHrP,Ptch and Bcl-2 were decreased to varying degrees in a cyclo dose-dependent manner.However,the expression levels of lhh and p21 mRNA were increased.The protein expres-sion of Ptch and Ihh had the same change as the mRNA expression.Meanwhile,cyclo could obvi-ously inhibit the proliferation and promote the apoptosis of PSCs.The results indicated that Ihh sig-naling pathway plays an important role in regulating the proliferation and apoptosis of PSCs,which is probably mediated by Bcl-2 and p21.

  17. Description on the signal processing system of ATLAS facility

    International Nuclear Information System (INIS)

    In the present report, signal processing system and logic of ATLAS facility was explained. Input signals was categorized as the first-, second- and third-order EU (engineering unit) parameter according to the signal processing logic. The system integration was described in Chapter 2, and the signal process logic of different types of signals was presented in Chapter 3

  18. Hepatitis B virus polymerase blocks pattern recognition receptor signaling via interaction with DDX3: implications for immune evasion.

    Directory of Open Access Journals (Sweden)

    Haifeng Wang

    Full Text Available Viral infection leads to induction of pattern-recognition receptor signaling, which leads to interferon regulatory factor (IRF activation and ultimately interferon (IFN production. To establish infection, many viruses have strategies to evade the innate immunity. For the hepatitis B virus (HBV, which causes chronic infection in the liver, the evasion strategy remains uncertain. We now show that HBV polymerase (Pol blocks IRF signaling, indicating that HBV Pol is the viral molecule that effectively counteracts host innate immune response. In particular, HBV Pol inhibits TANK-binding kinase 1 (TBK1/IkappaB kinase-epsilon (IKKepsilon, the effector kinases of IRF signaling. Intriguingly, HBV Pol inhibits TBK1/IKKepsilon activity by disrupting the interaction between IKKepsilon and DDX3 DEAD box RNA helicase, which was recently shown to augment TBK1/IKKepsilon activity. This unexpected role of HBV Pol may explain how HBV evades innate immune response in the early phase of the infection. A therapeutic implication of this work is that a strategy to interfere with the HBV Pol-DDX3 interaction might lead to the resolution of life-long persistent infection.

  19. Purinergic signaling pathways in endocrine system.

    Science.gov (United States)

    Bjelobaba, Ivana; Janjic, Marija M; Stojilkovic, Stanko S

    2015-09-01

    Adenosine-5'-triphosphate is released by neuroendocrine, endocrine, and other cell types and acts as an extracellular agonist for ligand-gated P2X cationic channels and G protein-coupled P2Y receptors in numerous organs and tissues, including the endocrine system. The breakdown of ATP by ectonucleotidases not only terminates its extracellular messenger functions, but also provides a pathway for the generation of two additional agonists: adenosine 5'-diphosphate, acting via some P2Y receptors, and adenosine, a native agonist for G protein-coupled adenosine receptors, also expressed in the endocrine system. This article provides a review of purinergic signaling pathways in the hypothalamic magnocellular neurosecretory cells and neurohypophysis, hypothalamic parvocellular neuroendocrine system, adenohypophysis, and effector glands organized in five axes: hypothalamic-pituitary-gonadal, hypothalamic-pituitary-thyroid, hypothalamic-pituitary-adrenal, hypothalamic-pituitary-growth hormone, and hypothalamic-pituitary-prolactin. We attempted to summarize current knowledge of purinergic receptor subtypes expressed in the endocrine system, including their roles in intracellular signaling, hormone secretion, and other cell functions. We also briefly review the release mechanism for adenosine-5'-triphosphate by neuroendocrine, endocrine and surrounding cells, the enzymes involved in adenosine-5'-triphosphate hydrolysis to adenosine-5'-diphosphate and adenosine, and the relevance of this pathway for sequential activation of receptors and termination of signaling.

  20. SiC Multi-Chip Power Modules as Power-System Building Blocks

    Science.gov (United States)

    Lostetter, Alexander; Franks, Steven

    2007-01-01

    The term "SiC MCPMs" (wherein "MCPM" signifies "multi-chip power module") denotes electronic power-supply modules containing multiple silicon carbide power devices and silicon-on-insulator (SOI) control integrated-circuit chips. SiC MCPMs are being developed as building blocks of advanced expandable, reconfigurable, fault-tolerant power-supply systems. Exploiting the ability of SiC semiconductor devices to operate at temperatures, breakdown voltages, and current densities significantly greater than those of conventional Si devices, the designs of SiC MCPMs and of systems comprising multiple SiC MCPMs are expected to afford a greater degree of miniaturization through stacking of modules with reduced requirements for heat sinking. Moreover, the higher-temperature capabilities of SiC MCPMs could enable operation in environments hotter than Si-based power systems can withstand. The stacked SiC MCPMs in a given system can be electrically connected in series, parallel, or a series/parallel combination to increase the overall power-handling capability of the system. In addition to power connections, the modules have communication connections. The SOI controllers in the modules communicate with each other as nodes of a decentralized control network, in which no single controller exerts overall command of the system. Control functions effected via the network include synchronization of switching of power devices and rapid reconfiguration of power connections to enable the power system to continue to supply power to a load in the event of failure of one of the modules. In addition to serving as building blocks of reliable power-supply systems, SiC MCPMs could be augmented with external control circuitry to make them perform additional power-handling functions as needed for specific applications: typical functions could include regulating voltages, storing energy, and driving motors. Because identical SiC MCPM building blocks could be utilized in a variety of ways, the cost

  1. Control analysis of systems with reaction blocks that 'cross-talk'.

    Science.gov (United States)

    Ainscow, E K; Brand, M D

    1998-09-01

    Practical application of metabolic control analysis has been facilitated by use of the top-down approach, which divides a metabolic system into a small number of reaction blocks, linked by a few key intermediates. Previous papers have stressed that communication between blocks should be only through the explicit intermediates, 'cross-talk' between reaction blocks invalidated the approach. Here we show how the restriction is a result of the use of inhibitors of the blocks, and can be overcome if other system modulations are used. We also show a way to treat the related problem of enzymes that appear in more than one block such as the analysis of glycolytic substrate cycles into ATP consuming and net flux activities.

  2. Suramin blocks interaction between human FGF1 and FGFR2 D2 domain and reduces downstream signaling activity.

    Science.gov (United States)

    Wu, Zong-Sian; Liu, Che Fu; Fu, Brian; Chou, Ruey-Hwang; Yu, Chin

    2016-09-01

    The extracellular portion of the human fibroblast growth factor receptor2 D2 domain (FGFR2 D2) interacts with human fibroblast growth factor 1 (hFGF1) to activate a downstream signaling cascade that ultimately affects mitosis and differentiation. Suramin is an antiparasiticdrug and a potent inhibitor of FGF-induced angiogenesis. Suramin has been shown to bind to hFGF1, and might block the interaction between hFGF1 and FGFR2 D2. Here, we titrated hFGF1 with FGFR2 D2 and suramin to elucidate their interactions using the detection of NMR. The docking results of both hFGF1-FGFR2 D2 domain and hFGF1-suramin complex were superimposed. The results indicate that suramin blocks the interaction between hFGF1 and FGFR2 D2. We used the PyMOL software to show the hydrophobic interaction of hFGF1-suramin. In addition, we used a Water-soluble Tetrazolium salts assay (WST1) to assess hFGF1 bioactivity. The results will be useful for the development of new antimitogenic activity drugs. PMID:27387234

  3. Blocking transforming growth factor- receptor signaling down-regulates transforming growth factor-β1 autoproduction in keloid fibroblasts

    Institute of Scientific and Technical Information of China (English)

    刘伟; 蔡泽浩; 王丹茹; 武小莉; 崔磊; 商庆新; 钱云良; 曹谊林

    2002-01-01

    Objective: To study transforming growth factor-β1(TGF-β1) autoproduction in keloid fibroblasts and theregulation effect of blocking TGF-β intracellular signalingon rhTGF-β1 autoproduction.Methods: Keloid fibroblasts cultured in vitro weretreated with either rhTGF-β1 (5 ng/ml ) or recombinantadenovirus containing a truncated type II TGF-β receptorgene (50 pfu/cell ). Their effects of regulating geneexpression of TGF-β1 and its receptor I and II wereobserved with Northern blot.Results: rhTGF-β1 up-regulated the gene expressionof TGF-β1 and receptor I, but not receptor II. Over-expression of the truncated receptor II down-regulated thegene expression of TGF-β1 and its receptor I, but notreceptor II.Conclusions: TGF-β1 autoproduction was observed inkeloid fibroblasts. Over-expression of the truncated TGF-βreceptor H decreased TGF-β1 autoproduction via blockingTGF-β receptor signaling.

  4. Signals and Systems in Biomedical Engineering Signal Processing and Physiological Systems Modeling

    CERN Document Server

    Devasahayam, Suresh R

    2013-01-01

    The use of digital signal processing is ubiquitous in the field of physiology and biomedical engineering. The application of such mathematical and computational tools requires a formal or explicit understanding of physiology. Formal models and analytical techniques are interlinked in physiology as in any other field. This book takes a unitary approach to physiological systems, beginning with signal measurement and acquisition, followed by signal processing, linear systems modelling, and computer simulations. The signal processing techniques range across filtering, spectral analysis and wavelet analysis. Emphasis is placed on fundamental understanding of the concepts as well as solving numerical problems. Graphs and analogies are used extensively to supplement the mathematics. Detailed models of nerve and muscle at the cellular and systemic levels provide examples for the mathematical methods and computer simulations. Several of the models are sufficiently sophisticated to be of value in understanding real wor...

  5. Methods for Setting up a Three-Dimensional Industrial Surveying System of "Building Blocks Type"

    Institute of Scientific and Technical Information of China (English)

    FENG Wenhao

    2004-01-01

    This paper is to advance some relevant techniques to set up a three-dimensional industrial surveying system of "building blocks type", making use of the electronic theodolite, standard ruler and portable computer.

  6. Development of Test Article Building Block (TABB) for deployable platform systems

    Science.gov (United States)

    Greenberg, H. S.; Barbour, R. T.

    1984-01-01

    The concept of a Test Article Building Block (TABB) is described. The TABB is a ground test article that is representative of a future building block that can be used to construct LEO and GEO deployable space platforms for communications and scientific payloads. This building block contains a main housing within which the entire structure, utilities, and deployment/retraction mechanism are stowed during launch. The end adapter secures the foregoing components to the housing during launch. The main housing and adapter provide the necessary building-block-to-building-block attachments for automatically deployable platforms. Removal from the shuttle cargo bay can be accomplished with the remote manipulator system (RMS) and/or the handling and positioning aid (HAPA). In this concept, all the electrical connections are in place prior to launch with automatic latches for payload attachment provided on either the end adapters or housings. The housings also can contain orbiter docking ports for payload installation and maintenance.

  7. Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance.

    Science.gov (United States)

    Kraakman, Michael J; Kammoun, Helene L; Allen, Tamara L; Deswaerte, Virginie; Henstridge, Darren C; Estevez, Emma; Matthews, Vance B; Neill, Bronwyn; White, David A; Murphy, Andrew J; Peijs, Lone; Yang, Christine; Risis, Steve; Bruce, Clinton R; Du, Xiao-Jun; Bobik, Alex; Lee-Young, Robert S; Kingwell, Bronwyn A; Vasanthakumar, Ajithkumar; Shi, Wei; Kallies, Axel; Lancaster, Graeme I; Rose-John, Stefan; Febbraio, Mark A

    2015-03-01

    Interleukin-6 (IL-6) plays a paradoxical role in inflammation and metabolism. The pro-inflammatory effects of IL-6 are mediated via IL-6 "trans-signaling," a process where the soluble form of the IL-6 receptor (sIL-6R) binds IL-6 and activates signaling in inflammatory cells that express the gp130 but not the IL-6 receptor. Here we show that trans-signaling recruits macrophages into adipose tissue (ATM). Moreover, blocking trans-signaling with soluble gp130Fc protein prevents high-fat diet (HFD)-induced ATM accumulation, but does not improve insulin action. Importantly, however, blockade of IL-6 trans-signaling, unlike complete ablation of IL-6 signaling, does not exacerbate obesity-induced weight gain, liver steatosis, or insulin resistance. Our data identify the sIL-6R as a critical chemotactic signal for ATM recruitment and suggest that selectively blocking IL-6 trans-signaling may be a more favorable treatment option for inflammatory diseases, compared with current treatments that completely block the action of IL-6 and negatively impact upon metabolic homeostasis.

  8. On parallel multisplitting block iterative methods for linear systems arising in the numerical solution of Euler equations

    OpenAIRE

    Zhang, Cheng-Yi; Luo, Shuanghua; Xu, Zongben

    2014-01-01

    The paper studies the convergence of some parallel multisplitting block iterative methods for the solution of linear systems arising in the numerical solution of Euler equations. Some sufficient conditions for convergence are proposed. As special cases the convergence of the parallel block generalized AOR (BGAOR), the parallel block AOR (BAOR), the parallel block generalized SOR (BGSOR), the parallel block SOR (BSOR), the extrapolated parallel BAOR and the extrapolated parallel BSOR methods a...

  9. Implementation of configuration dependent stiffness proportional damping for the dynamics of rigid multi-block systems

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    The distinct element method (DEM) has been used successfully for the dynamic analysis of rigid block systems. One of many difficulties associated with DEM is modeling of damping. In this paper, new procedures are proposed for the damping modeling and its numerical implementation in distinct element analysis of rigid multi-block systems. The stiffness proportional damping is constructed for the prescribed damping ratio, based on the non-zero fundamental frequency effective during the time interval while the boundary conditions remain essentially constant. At this time interval, the fundamental frequency can be estimated without complete eigenvalue analysis. The damping coefficients will vary while the damping ratio remains the same throughout the entire analysis. A new numerical procedure is developed to prevent unnecessary energy loss that can occur during the separation phases. These procedures were implemented in the development of the distinct element method for the dynamic analyses of piled multi-block systems. The analysis results for the single-block and two-block systems were in a good agreement with the analytic predictions. Applications to the seismic analyses of piled four-block systems revealed that the new procedures can make a significant difference and may lead to much-improved results.

  10. A block zero-padding method based on DCFT for L1 parameter estimations in weak signal and high dynamic environments

    Institute of Scientific and Technical Information of China (English)

    Chao WU; Lu-ping XU; Hua ZHANG; Wen-bo ZHAO

    2015-01-01

    Weak L1 signal acquisition in a high dynamic environment primarily faces a challenge:the integration peak is neg-atively influenced by the possible bit sign reversal every 20 ms and the frequency error. The block accumulating semi-coherent integration of correlations (BASIC) is a state-of-the-art method, but calculating the inter-block conjugate products restricts BASIC in a low signal-to-noise ratio (SNR) acquisition. We propose a block zero-padding method based on a discrete chirp-Fourier transform (DCFT) for parameter estimations in weak signal and high dynamic environments. Compared with the conventional receiver architecture that uses closed-loop acquisition and tracking, it is more suitable for open-loop acquisition. The proposed method combines DCFT and block zero-padding. In this way, the post-correlation signal is coherently post-integrated with the bit sequence stripped off, and the high dynamic parameters are precisely estimated using the threshold set based on a false alarm probability. In addition, the detection performance of the proposed method is analyzed. Simulation results show that compared with the BASIC method, the proposed method can precisely detect the high dynamic parameters in lower SNR when the length of the received signal is fixed.

  11. AN OPTIMAL BLOCK PREVENTIVE MAINTENANCE POLICY FOR A MULTI-UNIT SYSTEM CONSIDERING IMPERFECT MAINTENANCE

    OpenAIRE

    Park, J. H.; Lee, S. C.; J. W. HONG; C. H. LIE

    2009-01-01

    A block preventive maintenance (PM) policy for a multi-unit system composed of identical units is investigated in this paper. The block PM model of this paper considers periodic inspection and periodic imperfect maintenance. The imperfect maintenance effects are formulated using improvement factor and age reduction model. We define variables of maintenance policy as the inspection period and the PM period and obtain an optimal maintenance policy which minimizes the average total cost. A numer...

  12. A completely transparent, adhesively bonded soda-lime glass block masonry system

    OpenAIRE

    Faidra Oikonomopoulou; Fred Veer; Rob Nijsse; K. Baardolf

    2015-01-01

    A pioneering, all transparent, self-supporting glass block facade is presented in this paper. Previously realized examples utilize embedded metal components in order to obtain the desired structural performance despite the fact that these elements greatly affect the facade’s overall transparency level. Undeniably, the oxymoron ‘transparency and strength’ remains the prime concern in such applications. In this paper, a new, innovative structural system for glass block facades is described, whi...

  13. Modular Analysis of Sequential Solution Methods for Almost Block Diagonal Systems of Equations

    OpenAIRE

    El-Mistikawy, Tarek M. A.

    2013-01-01

    Almost block diagonal linear systems of equations can be exemplified by two modules. This makes it possible to construct all sequential forms of band and/or block elimination methods. It also allows easy assessment of the methods on the basis of their operation counts, storage needs, and admissibility of partial pivoting. The outcome of the analysis and implementation is to discover new methods that outperform a well-known method, a modification of which is, therefore, advocated.

  14. Motor activity of stomach and duodenum while blocking NO-ergic system

    OpenAIRE

    O. O. Galyns’ky; A. S. Trushenko; V. O. Galyns’ky; O. V. Severynovs’ka; A. I. Rudenko

    2010-01-01

    The features of ultradian rhythms of the stomach and duodenum of rats under different time spans of blocking NO-synthase and the associated disturbance of regulatory mechanisms have been investigated. The functional relationship between changes in the МEA of stomach and duodenum, as well as the morphological status of the mucous membrane under disturbance of the nitric monoxide synthesis have been established. Each time blocking NO-ergic system caused an increase in motor performance index of...

  15. ANALYSIS OF EXISTING AND PROSPECTIVE TECHNICAL CONTROL SYSTEMS OF NUMERIC CODES AUTOMATIC BLOCKING

    Directory of Open Access Journals (Sweden)

    A. M. Beznarytnyy

    2013-09-01

    Full Text Available Purpose. To identify the characteristic features of the engineering control measures system of automatic block of numeric code, identifying their advantages and disadvantages, to analyze the possibility of their use in the problems of diagnosing status of the devices automatic block and setting targets for the development of new diagnostic systems. Methodology. In order to achieve targets the objective theoretical and analytical method and the method of functional analysis have been used. Findings. The analysis of existing and future facilities of the remote control and diagnostics automatic block devices had shown that the existing systems of diagnosis were not sufficiently informative, designed primarily to control the discrete parameters, which in turn did not allow them to construct a decision support subsystem. In developing of new systems of technical diagnostics it was proposed to use the principle of centralized distributed processing of diagnostic data, to include a subsystem support decision-making in to the diagnostics system, it will reduce the amount of work to maintain the devices blocking and reduce recovery time after the occurrence injury. Originality. As a result, the currently existing engineering controls facilities of automatic block can not provide a full assessment of the state distillation alarms and locks. Criteria for the development of new systems of technical diagnostics with increasing amounts of diagnostic information and its automatic analysis were proposed. Practical value. These results of the analysis can be used in practice in order to select the technical control of automatic block devices, as well as the further development of diagnostic systems automatic block that allows for a gradual transition from a planned preventive maintenance service model to the actual state of the monitored devices.

  16. A completely transparent, adhesively bonded soda-lime glass block masonry system

    Directory of Open Access Journals (Sweden)

    Faidra Oikonomopoulou

    2015-06-01

    Full Text Available A pioneering, all transparent, self-supporting glass block facade is presented in this paper. Previously realized examples utilize embedded metal components in order to obtain the desired structural performance despite the fact that these elements greatly affect the facade’s overall transparency level. Undeniably, the oxymoron ‘transparency and strength’ remains the prime concern in such applications. In this paper, a new, innovative structural system for glass block facades is described, which demonstrably meets both criteria. The structure is exclusively constructed by monolithic glass blocks, bonded with a colourless, UV-curing adhesive, obtaining thus a maximum transparency. In addition, the desired structural performance is achieved solely through the masonry system, without any opaque substructure. Differing from previous realized projects, solid soda-lime glass blocks are used rather than borosilicate ones. This article provides an overview of the integrated architectural and structural design and discusses the choice of materials. The structural verification of the system is demonstrated. The results show that the adhesively bonded glass block structure has the required self-structural behaviour, but only if strict tolerances are met in the geometry of the glass blocks.  

  17. A completely transparent, adhesively bonded soda-lime glass block masonry system

    Directory of Open Access Journals (Sweden)

    F. Oikonomopoulou

    2015-01-01

    Full Text Available A pioneering, all transparent, self-supporting glass block facade is presented in this paper. Previously realized examples utilize embedded metal components in order to obtain the desired structural performance despite the fact that these elements greatly affect the facade’s overall transparency level. Undeniably, the oxymoron ‘transparency and strength’ remains the prime concern in such applications. In this paper, a new, innovative structural system for glass block facades is described, which demonstrably meets both criteria. The structure is exclusively constructed by monolithic glass blocks, bonded with a colourless, UV-curing adhesive, obtaining thus a maximum transparency. In addition, the desired structural performance is achieved solely through the masonry system, without any opaque substructure. Differing from previous realized projects, solid soda-lime glass blocks are used rather than borosilicate ones. This article provides an overview of the integrated architectural and structural design and discusses the choice of materials. The structural verification of the system is demonstrated. The results show that the adhesively bonded glass block structure has the required self-structural behaviour, but only if strict tolerances are met in the geometry of the glass blocks.

  18. Blocking Type I Interferon Signaling Rescues Lymphocytes from Oxidative Stress, Exhaustion, and Apoptosis in a Streptozotocin-Induced Mouse Model of Type I Diabetes

    OpenAIRE

    Ibrahim, Hany M.; El-Elaimy, Ibrahim A.; Saad Eldien, Heba M.; Badr Mohamed Badr; Rabah, Danny M.; Gamal Badr

    2013-01-01

    Elevated levels of type I interferon (IFN) during type 1 diabetes mellitus (T1D) are associated with a defective immune response. In the present study, we investigated whether blocking type I IFN signaling during streptozotocin- (STZ-) induced T1D in mice improves lymphocyte proliferation and escape from continuous apoptosis. Three groups of mice were examined: diabetic mice, type I IFN signaling-incompetent diabetic mice, and control nondiabetic mice. We first found that diabetes induction w...

  19. Development of the Functional Flow Block Diagram for the J-2X Rocket Engine System

    Science.gov (United States)

    White, Thomas; Stoller, Sandra L.; Greene, WIlliam D.; Christenson, Rick L.; Bowen, Barry C.

    2007-01-01

    The J-2X program calls for the upgrade of the Apollo-era Rocketdyne J-2 engine to higher power levels, using new materials and manufacturing techniques, and with more restrictive safety and reliability requirements than prior human-rated engines in NASA history. Such requirements demand a comprehensive systems engineering effort to ensure success. Pratt & Whitney Rocketdyne system engineers performed a functional analysis of the engine to establish the functional architecture. J-2X functions were captured in six major operational blocks. Each block was divided into sub-blocks or states. In each sub-block, functions necessary to perform each state were determined. A functional engine schematic consistent with the fidelity of the system model was defined for this analysis. The blocks, sub-blocks, and functions were sequentially numbered to differentiate the states in which the function were performed and to indicate the sequence of events. The Engine System was functionally partitioned, to provide separate and unique functional operators. Establishing unique functional operators as work output of the System Architecture process is novel in Liquid Propulsion Engine design. Each functional operator was described such that its unique functionality was identified. The decomposed functions were then allocated to the functional operators both of which were the inputs to the subsystem or component performance specifications. PWR also used a novel approach to identify and map the engine functional requirements to customer-specified functions. The final result was a comprehensive Functional Flow Block Diagram (FFBD) for the J-2X Engine System, decomposed to the component level and mapped to all functional requirements. This FFBD greatly facilitates component specification development, providing a well-defined trade space for functional trades at the subsystem and component level. It also provides a framework for function-based failure modes and effects analysis (FMEA), and a

  20. RESEARCH OF WAVELET TRANSFORM INSTRUMENT SYSTEM FOR SIGNAL ANALYSIS

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    After brief describing the principle of wavelet transform (WT) of signals, a new signals analysis system based on wavelet transform is introduced. The design and development of the instrument of wavelet transform are described. A number of practical uses of this system demonstrate that wavelet transform system is specially functional in identifying and processing impulse, singular and nonsmooth signals,so that it should be evaluated the most advanced signal analyzing system.

  1. Second International Conference on Communications, Signal Processing, and Systems

    CERN Document Server

    Mu, Jiasong; Wang, Wei; Liang, Qilian; Pi, Yiming

    2014-01-01

    The Proceedings of The Second International Conference on Communications, Signal Processing, and Systems provides the state-of-art developments of Communications, Signal Processing, and Systems. The conference covered such topics as wireless communications, networks, systems, signal processing for communications. This book is a collection of contributions coming out of The Second International Conference on Communications, Signal Processing, and Systems (CSPS) held September 2013 in Tianjin, China.

  2. System and method for traffic signal timing estimation

    KAUST Repository

    Dumazert, Julien

    2015-12-30

    A method and system for estimating traffic signals. The method and system can include constructing trajectories of probe vehicles from GPS data emitted by the probe vehicles, estimating traffic signal cycles, combining the estimates, and computing the traffic signal timing by maximizing a scoring function based on the estimates. Estimating traffic signal cycles can be based on transition times of the probe vehicles starting after a traffic signal turns green.

  3. 3rd International Conference on Communications, Signal Processing, and Systems

    CERN Document Server

    Liang, Qilian; Wang, Wei; Zhang, Baoju; Pi, Yiming

    2015-01-01

    The Proceedings of The Third International Conference on Communications, Signal Processing, and Systems provides the state-of-art developments of communications, signal processing, and systems. This book is a collection of contributions from the conference and covers such topics as wireless communications, networks, systems, and signal processing for communications. The conference was held July 2014 in Hohhot, Inner Mongolia, China.

  4. Pentamidine blocks the interaction between mutant S100A5 and RAGE V domain and inhibits the RAGE signaling pathway.

    Science.gov (United States)

    Cho, Ching Chang; Chou, Ruey Hwang; Yu, Chin

    2016-08-19

    The human S100 protein family contains small, dimeric and acidic proteins that contain two EF-hand motifs and bind calcium. When S100A5 binds calcium, its conformation changes and promotes interaction with the target protein. The extracellular domain of RAGE (Receptor of Advanced Glycation End products) contain three domains: C1, C2 and V. The RAGE V domain is the target protein of S100A5 that promotes cell survival, growth and differentiation by activating several signaling pathways. Pentamidine is an apoptotic and antiparasitic drug that is used to treat or prevent pneumonia. Here, we found that pentamidine interacts with S100A5 using HSQC titration. We elucidated the interactions of S100A5 with RAGE V domain and pentamidine using fluorescence and NMR spectroscopy. We generated two binary models-the S100A5-RAGE V domain and S100A5-Pentamidine complex-and then observed that the pentamidine and RAGE V domain share a similar binding region in mS100A5. We also used the WST-1 assay to investigate the bioactivity of S100A5, RAGE V domain and pentamidine. These results indicated that pentamidine blocks the binding between S100A5 and RAGE V domain. This finding is useful for the development of new anti-proliferation drugs. PMID:27297108

  5. Traffic Modelling for Moving-Block Train Control System

    Institute of Scientific and Technical Information of China (English)

    TANG Tao; LI Ke-Ping

    2007-01-01

    This paper presents a new cellular automaton (CA) model for train control system simulation.In the proposed CA model,the driver reactions to train movements are captured by some updated rules.The space-time diagram of traffic flow and the trajectory of train movement is used to obtain insight into the characteristic behavior of railway traffic flow.A number of simulation results demonstrate that the proposed CA model can be successfully used for the simulations of railway traffic.Not only the characteristic behavior of railway traffic flow can be reproduced,but also the simulation values of the minimum time headway are close to the theoretical values.

  6. Traffic Modelling for Moving-Block Train Control System

    International Nuclear Information System (INIS)

    This paper presents a new cellular automaton (CA) model for train control system simulation. In the proposed CA model, the driver reactions to train movements are captured by some updated rules. The space-time diagram of traffic flow and the trajectory of train movement is used to obtain insight into the characteristic behavior of railway traffic flow. A number of simulation results demonstrate that the proposed CA model can be successfully used for the simulations of railway traffic. Not only the characteristic behavior of railway traffic flow can be reproduced, but also the simulation values of the minimum time headway are close to the theoretical values.

  7. Analysis of the seismic signals generated by controlled single-block rockfalls on soft clay shales sediments: the Rioux Bourdoux slope experiment (French Alps).

    Science.gov (United States)

    Hibert, Clément; Provost, Floriane; Malet, Jean-Philippe; Bourrier, Franck; Berger, Frédéric; Bornemann, Pierrick; Borgniet, Laurent; Tardif, Pascal; Mermin, Eric

    2016-04-01

    Understanding the dynamics of rockfalls is critical to mitigate the associated hazards but is made very difficult by the nature of these natural disasters that makes them hard to observe directly. Recent advances in seismology allow to determine the dynamics of the largest landslides on Earth from the very low-frequency seismic waves they generate. However, the vast majority of rockfalls that occur worldwide are too small to generate such low-frequency seismic waves and thus these methods cannot be used to reconstruct their dynamics. However, if seismic sensors are close enough, these events will generate high-frequency seismic signals. Unfortunately we cannot yet use these high-frequency seismic records to infer parameters synthetizing the rockfall dynamics as the source of these waves is not well understood. One of the first steps towards understanding the physical processes involved in the generation of high-frequency seismic waves by rockfalls is to study the link between the dynamics of a single block propagating along a well-known path and the features of the seismic signal generated. We conducted controlled releases of single blocks of limestones in a gully of clay-shales (e.g. black marls) in the Rioux Bourdoux torrent (French Alps). 28 blocks, with masses ranging from 76 kg to 472 kg, were released. A monitoring network combining high-velocity cameras, a broadband seismometer and an array of 4 high-frequency seismometers was deployed near the release area and along the travel path. The high-velocity cameras allow to reconstruct the 3D trajectories of the blocks, to estimate their velocities and the position of the different impacts with the slope surface. These data are compared to the seismic signals recorded. As the distance between the block and the seismic sensors at the time of each impact is known, we can determine the associated seismic signal amplitude corrected from propagation and attenuation effects. We can further compare the velocity, the

  8. Increased Percentage of Passing Grades on the Massachusetts Comprehensive Assessment System after Implementation of Block Scheduling

    Science.gov (United States)

    Forman, Eric D.

    2009-01-01

    This study examined one public school system's change in its bell scheduling format from a seven period day to block scheduling. The data collected was from a three year period of the grade 10 students passing the Massachusetts Comprehensive Assessment System exam. Students in Massachusetts must pass the mathematics and English/language arts…

  9. Rapamycin targeting mTOR and hedgehog signaling pathways blocks human rhabdomyosarcoma growth in xenograft murine model

    Energy Technology Data Exchange (ETDEWEB)

    Kaylani, Samer Z. [Division of Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, 1600 7th Avenue South, ACC 414, Birmingham, AL 35233 (United States); Xu, Jianmin; Srivastava, Ritesh K. [Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, 1530 3rd Avenue South, VH 509, Birmingham, AL 35294-0019 (United States); Kopelovich, Levy [Division of Cancer Prevention, National Cancer Institute, Bethesda (United States); Pressey, Joseph G. [Division of Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, 1600 7th Avenue South, ACC 414, Birmingham, AL 35233 (United States); Athar, Mohammad, E-mail: mathar@uab.edu [Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, 1530 3rd Avenue South, VH 509, Birmingham, AL 35294-0019 (United States)

    2013-06-14

    Graphical abstract: Intervention of poorly differentiated RMS by rapamycin: In poorly differentiated RMS, rapamycin blocks mTOR and Hh signaling pathways concomitantly. This leads to dampening in cell cycle regulation and induction of apoptosis. This study provides a rationale for the therapeutic intervention of poorly differentiated RMS by treating patients with rapamycin alone or in combination with other chemotherapeutic agents. -- Highlights: •Rapamycin abrogates RMS tumor growth by modulating proliferation and apoptosis. •Co-targeting mTOR/Hh pathways underlie the molecular basis of effectiveness. •Reduction in mTOR/Hh pathways diminish EMT leading to reduced invasiveness. -- Abstract: Rhabdomyosarcomas (RMS) represent the most common childhood soft-tissue sarcoma. Over the past few decades outcomes for low and intermediate risk RMS patients have slowly improved while patients with metastatic or relapsed RMS still face a grim prognosis. New chemotherapeutic agents or combinations of chemotherapies have largely failed to improve the outcome. Based on the identification of novel molecular targets, potential therapeutic approaches in RMS may offer a decreased reliance on conventional chemotherapy. Thus, identification of effective therapeutic agents that specifically target relevant pathways may be particularly beneficial for patients with metastatic and refractory RMS. The PI3K/AKT/mTOR pathway has been found to be a potentially attractive target in RMS therapy. In this study, we provide evidence that rapamycin (sirolimus) abrogates growth of RMS development in a RMS xenograft mouse model. As compared to a vehicle-treated control group, more than 95% inhibition in tumor growth was observed in mice receiving parenteral administration of rapamycin. The residual tumors in rapamycin-treated group showed significant reduction in the expression of biomarkers indicative of proliferation and tumor invasiveness. These tumors also showed enhanced apoptosis

  10. 78 FR 47822 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System

    Science.gov (United States)

    2013-08-06

    ... discontinuance of the automatic block signal (ABS) system on Main Line 1 and 2, from Milepost (MP) 1.2 Bliss to... that the ABS system is no longer needed for freight switching operations. There are no through freight... published on April 11, 2000 (65 FR 19477). Robert C. Lauby, Deputy Associate Administrator for...

  11. Space-Time Block Coding for Time Slotted CDMA Systems with Frequency-Selective Fading

    Institute of Scientific and Technical Information of China (English)

    WANGYingmin; YIKechu; NIUZhongxia; TIANHongxin

    2003-01-01

    The radio channel fading is one of the most important physical limitations for wireless mobile communications. Space-time coding is a coding technique that is designed for use with multiple transmit antennas and offers an effective transmit diversity technique to combat fading. However, most existing space-time coding schemes assume fiat fading that may not be valid for wideband wireless mobile communication channels. In this paper, a novel spacetime block coding scheme based on block processing is proposed for time slotted CDMA systems with frequencyselective fading. In order to get quasi-orthogonality, we encode the information based on the two data fields (blocks) of a burst, other than the symbols in a data field (block). As a consequence, it is convenient for block processing of joint detection which can be used with just some small modifications of the algorithms with no space-time coding. For decoding the new space time codes, block linear joint detection algorithms are developed. Then, we simplify these algorithms with an iterative procedure. With moderate iterative times, the computation complexity of the simplified algorithms is much less than that of the exact algorithms. Simulation results show that the performance of the simplified joint detection algorithms approximates to that of the exact ones.

  12. The switching between zonal and blocked mid-latitude atmospheric circulation: a dynamical system perspective

    Science.gov (United States)

    Faranda, Davide; Masato, Giacomo; Moloney, Nicholas; Sato, Yuzuru; Daviaud, Francois; Dubrulle, Bérengère; Yiou, Pascal

    2016-09-01

    Atmospheric mid-latitude circulation is dominated by a zonal, westerly flow. Such a flow is generally symmetric, but it can be occasionally broken up by blocking anticyclones. The subsequent asymmetric flow can persist for several days. In this paper, we apply new mathematical tools based on the computation of an extremal index in order to reexamine the dynamical mechanisms responsible for the transitions between zonal and blocked flows. We discard the claim that mid-latitude circulation features two distinct stable equilibria or chaotic regimes, in favor of a simpler mechanism that is well understood in dynamical systems theory: we identify the blocked flow as an unstable fixed point (or saddle point) of a single basin chaotic attractor, dominated by the westerlies regime. We also analyze the North Atlantic Oscillation and the Arctic Oscillation atmospheric indices, whose behavior is often associated with the transition between the two circulation regimes, and investigate analogies and differences with the bidimensional blocking indices. We find that the Arctic Oscillation index, which can be thought as a proxy for a hemispheric average of the Tibaldi-Molteni blocking index, tracks unstable fixed points. On the other hand, the North Atlantic Oscillation, representative only for local properties of the North Atlantic blocking dynamics, does not show any trace of the presence of unstable fixed points of the dynamics.

  13. Differential Space-Time Block Code Modulation for DS-CDMA Systems

    Directory of Open Access Journals (Sweden)

    Liu Jianhua

    2002-01-01

    Full Text Available A differential space-time block code (DSTBC modulation scheme is used to improve the performance of DS-CDMA systems in fast time-dispersive fading channels. The resulting scheme is referred to as the differential space-time block code modulation for DS-CDMA (DSTBC-CDMA systems. The new modulation and demodulation schemes are especially studied for the down-link transmission of DS-CDMA systems. We present three demodulation schemes, referred to as the differential space-time block code Rake (D-Rake receiver, differential space-time block code deterministic (D-Det receiver, and differential space-time block code deterministic de-prefix (D-Det-DP receiver, respectively. The D-Det receiver exploits the known information of the spreading sequences and their delayed paths deterministically besides the Rake type combination; consequently, it can outperform the D-Rake receiver, which employs the Rake type combination only. The D-Det-DP receiver avoids the effect of intersymbol interference and hence can offer better performance than the D-Det receiver.

  14. System Performance of Concatenated STBC and Block Turbo Codes in Dispersive Fading Channels

    Directory of Open Access Journals (Sweden)

    Kam Tai Chan

    2005-05-01

    Full Text Available A new scheme of concatenating the block turbo code (BTC with the space-time block code (STBC for an OFDM system in dispersive fading channels is investigated in this paper. The good error correcting capability of BTC and the large diversity gain characteristics of STBC can be achieved simultaneously. The resulting receiver outperforms the iterative convolutional Turbo receiver with maximum- a-posteriori-probability expectation maximization (MAP-EM algorithm. Because of its ability to perform the encoding and decoding processes in parallel, the proposed system is easy to implement in real time.

  15. Performance of multi-service system with retrials due to blocking and called-party-busy

    DEFF Research Database (Denmark)

    Stepanov, S.N.; Kokina, O.A.; Iversen, Villy Bæk

    2008-01-01

    In this paper we construct a model of a multi-service system with an arbitrary number of bandwidth flow demands, taking into account retrials due to both blocking along the route and to called-party-busy. An approximate algorithm for estimation of key performance measures is proposed, and the pro......In this paper we construct a model of a multi-service system with an arbitrary number of bandwidth flow demands, taking into account retrials due to both blocking along the route and to called-party-busy. An approximate algorithm for estimation of key performance measures is proposed...

  16. Reconciling Compressive Sampling Systems for Spectrally-sparse Continuous-time Signals

    CERN Document Server

    Lexa, Michael A; Thompson, John S

    2011-01-01

    The Random Demodulator (RD) and the Modulated Wideband Converter (MWC) are two recently proposed compressed sensing (CS) techniques for the acquisition of continuous-time spectrally-sparse signals. They extend the standard CS paradigm from sampling discrete, finite dimensional signals to sampling continuous and possibly infinite dimensional ones, and thus establish the ability to capture these signals at sub-Nyquist sampling rates. The RD and the MWC have remarkably similar structures (similar block diagrams), but their reconstruction algorithms and signal models strongly differ. To date, few results exist that compare these systems, and owing to the potential impacts they could have on spectral estimation in applications like electromagnetic scanning and cognitive radio, we more fully investigate their relationship in this paper. Specifically, we show that the RD and the MWC are both based on the general concept of random filtering, but that the sampling functions characterising the systems differ significan...

  17. A hearing aid on-chip system based on accuracy optimized front- and back-end blocks

    International Nuclear Information System (INIS)

    A hearing aid on-chip system based on accuracy optimized front- and back-end blocks is presented for enhancing the signal processing accuracy of the hearing aid. Compared with the conventional system, the accuracy optimized system is characterized by the dual feedback network and the gain compensation technique used in the front- and back-end blocks, respectively, so as to alleviate the nonlinearity distortion caused by the output swing. By using the technique, the accuracy of the whole hearing aid system can be significantly improved. The prototype chip has been designed with a 0.13 μm standard CMOS process and tested with 1 V supply voltage. The measurement results show that, for driving a 16 Ω loudspeaker with a normalized output level of 300 mVp-p, the total harmonic distortion reached about −60 dB, achieving at least three times reduction compared to the previously reported works. In addition, the typical input referred noise is only about 5 μVrms. (semiconductor integrated circuits)

  18. A hearing aid on-chip system based on accuracy optimized front- and back-end blocks

    Science.gov (United States)

    Fanyang, Li; Hao, Jiang

    2014-03-01

    A hearing aid on-chip system based on accuracy optimized front- and back-end blocks is presented for enhancing the signal processing accuracy of the hearing aid. Compared with the conventional system, the accuracy optimized system is characterized by the dual feedback network and the gain compensation technique used in the front- and back-end blocks, respectively, so as to alleviate the nonlinearity distortion caused by the output swing. By using the technique, the accuracy of the whole hearing aid system can be significantly improved. The prototype chip has been designed with a 0.13 μm standard CMOS process and tested with 1 V supply voltage. The measurement results show that, for driving a 16 Ω loudspeaker with a normalized output level of 300 mVp-p, the total harmonic distortion reached about -60 dB, achieving at least three times reduction compared to the previously reported works. In addition, the typical input referred noise is only about 5 μVrms.

  19. Effective System for Automatic Bundle Block Adjustment and Ortho Image Generation from Multi Sensor Satellite Imagery

    Science.gov (United States)

    Akilan, A.; Nagasubramanian, V.; Chaudhry, A.; Reddy, D. Rajesh; Sudheer Reddy, D.; Usha Devi, R.; Tirupati, T.; Radhadevi, P. V.; Varadan, G.

    2014-11-01

    Block Adjustment is a technique for large area mapping for images obtained from different remote sensingsatellites.The challenge in this process is to handle huge number of satellite imageries from different sources with different resolution and accuracies at the system level. This paper explains a system with various tools and techniques to effectively handle the end-to-end chain in large area mapping and production with good level of automation and the provisions for intuitive analysis of final results in 3D and 2D environment. In addition, the interface for using open source ortho and DEM references viz., ETM, SRTM etc. and displaying ESRI shapes for the image foot-prints are explained. Rigorous theory, mathematical modelling, workflow automation and sophisticated software engineering tools are included to ensure high photogrammetric accuracy and productivity. Major building blocks like Georeferencing, Geo-capturing and Geo-Modelling tools included in the block adjustment solution are explained in this paper. To provide optimal bundle block adjustment solution with high precision results, the system has been optimized in many stages to exploit the full utilization of hardware resources. The robustness of the system is ensured by handling failure in automatic procedure and saving the process state in every stage for subsequent restoration from the point of interruption. The results obtained from various stages of the system are presented in the paper.

  20. A Parallel Algorithm for Solving Block-diagonal Structured Large Linear System

    Institute of Scientific and Technical Information of China (English)

    SHEN Jie; ZHANG Zhong-lin; CHENG Ji-lin

    2001-01-01

    A parallel algorithm for solving block-diagonal structured large linear system is presented.This algorithm is based on the "gradient-simplex" method. It partitions a large linear system into several small linear subsystems so that they can be solved in parallel. The algorithm has the merit of high speed and is suitable for the large linear systems with less coupling constrains. The efficiency and applicability of the method is also analyzed.

  1. COMPUTER-BASED ECG SIGNAL ANALYSIS AND MONITORING SYSTEM

    OpenAIRE

    Nasser N. Khamiss Al-Ani; Hadeel Kassim Al-Jobouri

    2008-01-01

    This paper deals with the design and implementation of an ECG system. The proposed system gives a new concept of ECG signal manipulation, storing, and editing. It consists mainly of hardware circuits and the related software. The hardware includes the circuits of ECG signals capturing, and system interfaces. The software is written using Visual Basic languages, to perform the task of identification of the ECG signal. The main advantage of the system is to provide a reported ECG recording on a...

  2. Effect of signal modulating noise in bistable stochastic dynamical systems

    Institute of Scientific and Technical Information of China (English)

    肖方红; 闫桂荣; 张新武

    2003-01-01

    The effect of signal modulating noise in bistable stochastic dynamical systems is studied.The concept of instan taneous steady state is proposed for bistable dynamical systems.By making a dynamical analysis of bistable stochastic systems,we find that global and local effect of signal modulating noise as well as stochastic resonance can occur in bistable dynamical systems on which both a weak sinusoidal signal and noise are forced.The effect is demonstrated by numerical simulation.

  3. Blocking Type I Interferon Signaling Rescues Lymphocytes from Oxidative Stress, Exhaustion, and Apoptosis in a Streptozotocin-Induced Mouse Model of Type I Diabetes

    Directory of Open Access Journals (Sweden)

    Hany M. Ibrahim

    2013-01-01

    Full Text Available Elevated levels of type I interferon (IFN during type 1 diabetes mellitus (T1D are associated with a defective immune response. In the present study, we investigated whether blocking type I IFN signaling during streptozotocin- (STZ- induced T1D in mice improves lymphocyte proliferation and escape from continuous apoptosis. Three groups of mice were examined: diabetic mice, type I IFN signaling-incompetent diabetic mice, and control nondiabetic mice. We first found that diabetes induction was accompanied by an elevation in the plasma levels of reactive oxygen species (ROS, hydroperoxide, malondialdehyde (MDN, and the proinflammatory cytokines IL-1α, IL-1β, IL-6, and CXCL10. Blocking type 1 IFN signaling in diabetic mice significantly decreased the levels of oxidative stress and proinflammatory cytokines. In addition, lymphocytes from diabetic mice exhibited a marked reduction in their proliferative capacity, increased apoptosis, upregulation of the exhaustion marker PD-1, and aberrant phosphorylation of STAT1, STAT2, AKT and IκB-α. Interestingly, following the blocking of type I IFN signaling in diabetic mice, the lymphocytes exhibited restored proliferative capacity, decreased apoptosis, normal expression of PD-1, and normal phosphorylation of STAT1, STAT2, AKT and IκB-α. Our data suggest that elevated levels of type I IFN during T1D trigger lymphocyte exhaustion and a defective lymphocyte-medicated immune response.

  4. Normal mode analysis of macromolecular systems with the mobile block Hessian method

    Energy Technology Data Exchange (ETDEWEB)

    Ghysels, An; Van Speybroeck, Veronique; Van Neck, Dimitri; Waroquier, Michel [Center for Molecular Modeling, Ghent University, Technologiepark 903, 9052 Zwijnaarde (Belgium); Brooks, Bernard R. [Laboratory for Computational Biology, National Heart, Lung and Blood Institute, National Institutes of Health, 5636 Fisher' s Ln, Rockville, MD 20851 (United States)

    2015-01-22

    Until recently, normal mode analysis (NMA) was limited to small proteins, not only because the required energy minimization is a computationally exhausting task, but also because NMA requires the expensive diagonalization of a 3N{sub a}×3N{sub a} matrix with N{sub a} the number of atoms. A series of simplified models has been proposed, in particular the Rotation-Translation Blocks (RTB) method by Tama et al. for the simulation of proteins. It makes use of the concept that a peptide chain or protein can be seen as a subsequent set of rigid components, i.e. the peptide units. A peptide chain is thus divided into rigid blocks with six degrees of freedom each. Recently we developed the Mobile Block Hessian (MBH) method, which in a sense has similar features as the RTB method. The main difference is that MBH was developed to deal with partially optimized systems. The position/orientation of each block is optimized while the internal geometry is kept fixed at a plausible - but not necessarily optimized - geometry. This reduces the computational cost of the energy minimization. Applying the standard NMA on a partially optimized structure however results in spurious imaginary frequencies and unwanted coordinate dependence. The MBH avoids these unphysical effects by taking into account energy gradient corrections. Moreover the number of variables is reduced, which facilitates the diagonalization of the Hessian. In the original implementation of MBH, atoms could only be part of one rigid block. The MBH is now extended to the case where atoms can be part of two or more blocks. Two basic linkages can be realized: (1) blocks connected by one link atom, or (2) by two link atoms, where the latter is referred to as the hinge type connection. In this work we present the MBH concept and illustrate its performance with the crambin protein as an example.

  5. Prototypic implementations of the building block for component based open Hypermedia systems (BB/CB-OHSs)

    DEFF Research Database (Denmark)

    Mohamed, Omer I. Eldai

    2005-01-01

    In this paper we describe the prototypic implementations of the BuildingBlock (BB/CB-OHSs) that proposed to address some of the Component-based Open Hypermedia Systems (CB-OHSs) issues, including distribution and interoperability [4, 11, 12]. Four service implementations were described below. The...

  6. Blocking Probability Based Hierarchical Storage Design in VoD Systems

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    In this paper, we discuss the relationship between the blocking probability and the configuration of storage hierarchy in a Video on Demand (VoD) server using the queueing model we propose. With this model , the optimal configuration of the storage system can be obtained.

  7. BLOCK OF FUZZY MODELS FOR CALCULATION OF THE ECONOMIC PARAMETERS IN A TECHNOLOGICALLY INTEGRATED PRODUCTION SYSTEM

    Directory of Open Access Journals (Sweden)

    Baranovskaya T. P.

    2014-06-01

    Full Text Available The article describes the fuzzy-multiple approach and the block of fuzzy (interval mathematical models developed by the authors for calculating the amounts of material and financial flows, prices for bread and economic efficiency in a technologically integrated bread production system

  8. Adaptive rational block Arnoldi methods for model reductions in large-scale MIMO dynamical systems

    Directory of Open Access Journals (Sweden)

    Khalide Jbilou

    2016-04-01

    Full Text Available In recent years, a great interest has been shown towards Krylov subspace techniques applied to model order reduction of large-scale dynamical systems. A special interest has been devoted to single-input single-output (SISO systems by using moment matching techniques based on Arnoldi or Lanczos algorithms. In this paper, we consider multiple-input multiple-output (MIMO dynamical systems and introduce the rational block Arnoldi process to design low order dynamical systems that are close in some sense to the original MIMO dynamical system. Rational Krylov subspace methods are based on the choice of suitable shifts that are selected a priori or adaptively. In this paper, we propose an adaptive selection of those shifts and show the efficiency of this approach in our numerical tests. We also give some new block Arnoldi-like relations that are used to propose an upper bound for the norm of the error on the transfer function.

  9. A convergence analysis for a sweeping preconditioner for block tridiagonal systems of linear equations

    KAUST Repository

    Bagci, Hakan

    2014-11-11

    We study sweeping preconditioners for symmetric and positive definite block tridiagonal systems of linear equations. The algorithm provides an approximate inverse that can be used directly or in a preconditioned iterative scheme. These algorithms are based on replacing the Schur complements appearing in a block Gaussian elimination direct solve by hierarchical matrix approximations with reduced off-diagonal ranks. This involves developing low rank hierarchical approximations to inverses. We first provide a convergence analysis for the algorithm for reduced rank hierarchical inverse approximation. These results are then used to prove convergence and preconditioning estimates for the resulting sweeping preconditioner.

  10. FunBlocks. A Modular Framework for AmI System Development

    Science.gov (United States)

    Baquero, Rafael; Rodríguez, José; Mendoza, Sonia; Decouchant, Dominique; Papis, Alfredo Piero Mateos

    2012-01-01

    The last decade has seen explosive growth in the technologies required to implement Ambient Intelligence (AmI) systems. Technologies such as facial and speech recognition, home networks, household cleaning robots, to name a few, have become commonplace. However, due to the multidisciplinary nature of AmI systems and the distinct requirements of different user groups, integrating these developments into full-scale systems is not an easy task. In this paper we propose FunBlocks, a minimalist modular framework for the development of AmI systems based on the function module abstraction used in the IEC 61499 standard for distributed control systems. FunBlocks provides a framework for the development of AmI systems through the integration of modules loosely joined by means of an event-driven middleware and a module and sensor/actuator catalog. The modular design of the FunBlocks framework allows the development of AmI systems which can be customized to a wide variety of usage scenarios. PMID:23112599

  11. Digital signal processing in communication systems

    CERN Document Server

    Frerking, Marvin E

    1994-01-01

    An engineer's introduction to concepts, algorithms, and advancements in Digital Signal Processing. This lucidly written resource makes extensive use of real-world examples as it covers all the important design and engineering references.

  12. System proportions fluid-flow in response to demand signals

    Science.gov (United States)

    1966-01-01

    Control system provides proportioned fluid flow rates in response to demand signals. It compares a digital signal, representing a flow demand, with a reference signal to yield a control voltage to one or more solenoid valves connected to orifices of a predetermined size.

  13. Information content in reflected global navigation satellite system signals

    DEFF Research Database (Denmark)

    Høeg, Per; Carlstrom, Anders

    2011-01-01

    The direct signals from satellites in global satellite navigation satellites systems (GNSS) as, GPS, GLONASS and GALILEO, constitute the primary source for positioning, navigation and timing from space. But also the reflected GNSS signals contain an important information content of signal travel...

  14. Notch signalling and proneural genes work together to control the neural building blocks for the initial scaffold in the hypothalamus

    Directory of Open Access Journals (Sweden)

    Michelle eWare

    2014-12-01

    Full Text Available The vertebrate embryonic prosencephalon gives rise to the hypothalamus, which plays essential roles in sensory information processing as well as control of physiological homeostasis and behaviour. While patterning of the hypothalamus has received much attention, initial neurogenesis in the developing hypothalamus has mostly been neglected. The first differentiating progenitor cells of the hypothalamus will give rise to neurons that form the nucleus of the tract of the postoptic commissure and the nucleus of the mammillotegmental tract. The formation of these neuronal populations has to be highly controlled both spatially and temporally as these tracts will form part of the ventral longitudinal tract and act as a scaffold for later, follower axons. This review will cumulate and summarise the existing data available describing initial neurogenesis in the vertebrate hypothalamus. It has only recently been proposed that loss of Notch signalling in the developing chick embryo causes an increase in the number of neurons in the hypothalamus, highlighting an early function of the Notch pathway during hypothalamus formation. It is well known that the Notch signalling pathway through the inhibition of proneural genes is a key regulator of neurogenesis in the vertebrate central nervous system. Scarce studies have shown genes such as Ascl1 and Hes5 are expressed in the hypothalamus earlier than when the first mature neurons appear. The timing of the transcriptional repressors of the Notch signalling pathway and proneural activators will be analysed. We will discuss novel targets that start to unravel the mechanisms behind neurogenesis in the hypothalamus. Given the critical role that hypothalamic neural circuitry plays in maintaining homeostasis, it is particularly important to establish the targets downstream of this Notch/proneural network.

  15. The synthesis of planar sp2 -bonded system from molecular building blocks

    Science.gov (United States)

    Zhang, Xin; Luo, Hong; Gu, Gong

    Biphenyl and pyrene molecules were deposited onto atomically flat Cu (100) surface as building blocks for the synthesis of planar, conjugated, sp2-bonded system. In situ STM observation confirmed the formation of highly-ordered lattice structure after annealing under UHV condition, as a result of the substrate-assisted dehydrogenation. The electronic properties of the system were examined by STS and will be presented. ONR N00014-15-1-2661.

  16. Effective System for Automatic Bundle Block Adjustment and Ortho Image Generation from Multi Sensor Satellite Imagery

    OpenAIRE

    A. Akilan; V. Nagasubramanian; Chaudhry, A.; Rajesh Reddy, D.; Sudheer Reddy, D.; Usha Devi, R.; Tirupati, T.; Radhadevi, P.V.; Varadan, G.

    2014-01-01

    Block Adjustment is a technique for large area mapping for images obtained from different remote sensingsatellites.The challenge in this process is to handle huge number of satellite imageries from different sources with different resolution and accuracies at the system level. This paper explains a system with various tools and techniques to effectively handle the end-to-end chain in large area mapping and production with good level of automation and the provisions for intuitive anal...

  17. PERIODIC SIGNAL DETECTION WITH USING DUFFING SYSTEM POINCARE MAP ANALYSIS

    Directory of Open Access Journals (Sweden)

    Valeriy Martynyuk

    2014-06-01

    Full Text Available In this article the periodic signal detection method on the base of Duffing system chaotic oscillations analysis is presented. This work is a development of the chaos-based signal detection technique. Generally, chaos-based signal detection is the detection of chaotic-to-periodic state transition under input periodic component influence. If the input periodic component reaches certain threshold value, the system transforms from chaotic state to periodic state. The Duffing-type chaotic systems are often used for such a signal detection purpose because of their ability to work in chaotic state for a long time and relatively simple realization. The main advantage of chaos-based signal detection methods is the utilization of chaotic system sensitivity to weak signals. But such methods are not used in practice because of the chaotic system state control problems. The method presented does not require an exact system state control. The Duffing system works continuously in chaotic state and the periodic signal detection process is based on the analysis of Duffing system Poincare map fractal structure. This structure does not depend on noise, and therefore the minimum input signal-to-noise ratio required for periodic signal detection is not limited by chaotic system state control tolerance.

  18. Block Copolymer Modified Epoxy Amine System for Reactive Rotational Molding: Structures, Properties and Processability

    Science.gov (United States)

    Lecocq, Eva; Nony, Fabien; Tcharkhtchi, Abbas; Gérard, Jean-François

    2011-05-01

    Poly(styrene-butadiene-methylmethacrylate) (SBM) and poly(methylmethacrylate-butyle-acrylate-methylmethacrylate) (MAM) triblock copolymers have been dissolved in liquid DGEBA epoxy resin which is subsequently polymerized by meta-xylene diamine (MXDA) or Jeffamine EDR-148. A chemorheology study of these formulations by plate-plate rheology and by thermal analysis has allowed to conclude that the addition of these copolymer blocks improve the reactive rotational moulding processability without affecting the processing time. Indeed, it prevents the pooling of the formulation at the bottom of the mould and a too rapid build up of resin viscosity of these thermosetting systems. The morphology of the cured blends examined by scanning electron microscopy (SEM) shows an increase of fracture surface area and thereby a potential increase of the toughness with the modification of epoxy system. Dynamic mechanical spectroscopy (DMA) and opalescence of final material show that the block PMMA, initially miscible, is likely to induce phase separation from the epoxy-amine matrix. Thereby, the poor compatibilisation between the toughener and the matrix has a detrimental effect on the tensile mechanical properties. The compatibilisation has to be increased to improve in synergy the processability and the final properties of these block copolymer modified formulations. First attempts could be by adapting the length and ratio of each block.

  19. Intelligent Signal Processing for Detection System Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Fu, C Y; Petrich, L I; Daley, P F; Burnham, A K

    2004-06-18

    A wavelet-neural network signal processing method has demonstrated approximately tenfold improvement in the detection limit of various nitrogen and phosphorus compounds over traditional signal-processing methods in analyzing the output of a thermionic detector attached to the output of a gas chromatograph. A blind test was conducted to validate the lower detection limit. All fourteen of the compound spikes were detected when above the estimated threshold, including all three within a factor of two above. In addition, two of six were detected at levels 1/2 the concentration of the nominal threshold. We would have had another two correct hits if we had allowed human intervention to examine the processed data. One apparent false positive in five nulls was traced to a solvent impurity, whose presence was identified by running a solvent aliquot evaporated to 1% residual volume, while the other four nulls were properly classified. We view this signal processing method as broadly applicable in analytical chemistry, and we advocate that advanced signal processing methods be applied as directly as possible to the raw detector output so that less discriminating preprocessing and post-processing does not throw away valuable signal.

  20. Intelligent Signal Processing for Detection System Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Fu, C Y; Petrich, L I; Daley, P F; Burnham, A K

    2004-12-05

    A wavelet-neural network signal processing method has demonstrated approximately tenfold improvement over traditional signal-processing methods for the detection limit of various nitrogen and phosphorus compounds from the output of a thermionic detector attached to a gas chromatograph. A blind test was conducted to validate the lower detection limit. All fourteen of the compound spikes were detected when above the estimated threshold, including all three within a factor of two above the threshold. In addition, two of six spikes were detected at levels of 1/2 the concentration of the nominal threshold. Another two of the six would have been detected correctly if we had allowed human intervention to examine the processed data. One apparent false positive in five nulls was traced to a solvent impurity, whose presence was subsequently identified by analyzing a solvent aliquot evaporated to 1% residual volume, while the other four nulls were properly classified. We view this signal processing method as broadly applicable in analytical chemistry, and we advocate that advanced signal processing methods should be applied as directly as possible to the raw detector output so that less discriminating preprocessing and post-processing does not throw away valuable signal.

  1. A novel image block cryptosystem based on a spatiotemporal chaotic system and a chaotic neural network

    Institute of Scientific and Technical Information of China (English)

    Wang Xing-Yuan; Bao Xue-Mei

    2013-01-01

    In this paper,we propose a novel block cryptographic scheme based on a spatiotemporal chaotic system and a chaotic neural network (CNN).The employed CNN comprises a 4-neuron layer called a chaotic neuron layer (CNL),where the spatiotemporal chaotic system participates in generating its weight matrix and other parameters.The spatiotemporal chaotic system used in our scheme is the typical coupled map lattice (CML),which can be easily implemented in parallel by hardware.A 160-bit-long binary sequence is used to generate the initial conditions of the CML.The decryption process is symmetric relative to the encryption process.Theoretical analysis and experimental results prove that the block cryptosystem is secure and practical,and suitable for image encryption.

  2. Adaptability of the Logistics System in National Economic Mobilization Based on Blocking Flow Theory

    Directory of Open Access Journals (Sweden)

    Xiangyuan Jing

    2014-01-01

    Full Text Available In the process of national economic mobilization, the logistics system usually suffers from negative impact and/or threats of such emergency events as wars and accidents, which implies that adaptability of the logistics system directly determines realization of economic mobilization. And where the real-time rescue operation is concerned, heavy traffic congestion is likely to cause a great loss of or damage to human beings and their properties. To deal with this situation, this article constructs a blocking-resistance optimum model and an optimum restructuring model based on blocking flow theories, of which both are illustrated by numerical cases and compared in characteristics and application. The design of these two models is expected to eliminate or alleviate the congestion situation occurring in the logistics system, thus effectively enhancing its adaptability in the national economic mobilization process.

  3. PAPR reduction in optical OFDM systems using asymmetrically clipping and signal scrambling technique

    Science.gov (United States)

    Chen, Lin; Fang, Yong; Huang, Qinghua; Sun, Yanzan

    2015-08-01

    Optical orthogonal frequency division multiplexing (OOFDM) is a promising technology in the next generation of high-speed and long-haul optical transmission, due to its high spectral efficiency, high speed of data transmission and strong ability of anti-dispersion. But optical OFDM system has a very high peak-to-average power ratio (PAPR). High PAPR will bring instantaneous high optical power to the optical OFDM system. Asymmetrically clipping and signal scrambling based on fast Hartley transform for PAPR reduction is proposed in optical OFDM system. Firstly, IFFT/FFT module in each sub-block of traditional signal scrambling technique is replaced with inverse fast Hartley transform (IFHT) and fast Hartley transform (FHT) module, which yield to the real signal in OOFDM system. Then, asymmetrically clipping technique is applied to turn it into a positive and real signal. Finally, the signal with the minimum PAPR is selected for transmission in the fiber channel. The PAPR of the optical OFDM signal can be reduced effectively. And without the Hermitian symmetry, the space and computational complexity are reduced accordingly.

  4. Systemin/Jasmonate-Mediated Systemic Defense Signaling in Tomato

    Institute of Scientific and Technical Information of China (English)

    Jia-Qiang Sun; Hong-Ling Jiang; Chuan-You Li

    2011-01-01

    Wound-inducible proteinase inhibitors (Pis)in tomato plants provide a useful model system to elucidate the signal transduction pathways that regulate systemic defense response. Among the proposed intercellular signals for wound-induced Pis expression are the peptide systemin and the oxylipin-derived phytohormone jasmonic acid (JA).An increasing body of evidence indicates that systemin and JA work in the same signaling pathway to activate the ex-pression of Pis and other defense-related genes. However, relatively less is known about how these signals interact to promote cell-to-cell communication over long distances. Genetic analysis of the systemin/JA signaling pathway in tomato plants provides a unique opportunity to study, in a single experimental system, the mechanism by which peptide and oxylipin signals interact to coordinate systemic expression of defense-related genes. Previously, it has been proposed that systemin is the long-distance mobile signal for defense gene expression. Recently, grafting experiments with tomato mutants defective in JA biosynthesis and signaling provide new evidence that JA, rather than systemin, functions as the systemic wound signal, and that the biosynthesis of JA is regulated by the peptide systemin. Further understanding of the systemin/JA signaling pathway promises to provide new insights into the basic mechanisms governing plant de-fense to biotic stress.

  5. Developing a synthetic signal transduction system in plants.

    Science.gov (United States)

    Morey, Kevin J; Antunes, Mauricio S; Albrecht, Kirk D; Bowen, Tessa A; Troupe, Jared F; Havens, Keira L; Medford, June I

    2011-01-01

    One area of focus in the emerging field of plant synthetic biology is the manipulation of systems involved in sensing and response to environmental signals. Sensing and responding to signals, including ligands, typically involves biological signal transduction. Plants use a wide variety of signaling systems to sense and respond to their environment. One of these systems, a histidine kinase (HK) based signaling system, lends itself to manipulation using the tools of synthetic biology. Both plants and bacteria use HKs to relay signals, which in bacteria can involve as few as two proteins (two-component systems or TCS). HK proteins are evolutionarily conserved between plants and bacteria and plant HK components have been shown to be functional in bacteria. We found that this conservation also applies to bacterial HK components which can function in plants. This conservation of function led us to hypothesize that synthetic HK signaling components can be designed and rapidly tested in bacteria. These novel HK signaling components form the foundation for a synthetic signaling system in plants, but typically require modifications such as codon optimization and proper targeting to allow optimal function. We describe the process and methodology of producing a synthetic signal transduction system in plants. We discovered that the bacterial response regulator (RR) PhoB shows HK-dependent nuclear translocation in planta. Using this discovery, we engineered a partial synthetic pathway in which a synthetic promoter (PlantPho) is activated using a plant-adapted PhoB (PhoB-VP64) and the endogenous HK-based cytokinin signaling pathway. Building on this work, we adapted an input or sensing system based on bacterial chemotactic binding proteins and HKs, resulting in a complete eukaryotic signal transduction system. Input to our eukaryotic signal transduction system is provided by a periplasmic binding protein (PBP), ribose-binding protein (RBP). RBP interacts with the membrane

  6. Signal amplification in a qubit-resonator system

    International Nuclear Information System (INIS)

    We study the dynamics of a qubit-resonator system, when the resonator is driven by two signals. The interaction of the qubit with the high-amplitude driving we consider in terms of the qubit dressed states. Interaction of the dressed qubit with the second probing signal can essentially change the amplitude of this signal. We calculate the transmission amplitude of the probe signal through the resonator as a function of the qubit energy and the driving frequency detuning. The regions of increase and attenuation of the transmitted signal are calculated and demonstrated graphically. We present the influence of the signal parameters on the value of the amplification, and discuss the values of the qubit-resonator system parameters for an optimal amplification and attenuation of the weak probe signal.

  7. Holographic view on quantum correlations and mutual information between disjoint blocks of a quantum critical system

    Science.gov (United States)

    Molina-Vilaplana, Javier; Sodano, Pasquale

    2011-10-01

    In ( d + 1) dimensional Multiscale Entanglement Renormalization Ansatz (MERA) networks, tensors are connected so as to reproduce the discrete, ( d + 2) holographic geometry of Anti de Sitter space (AdS d+2) with the original system lying at the boundary. We analyze the MERA renormalization flow that arises when computing the quantum correlations between two disjoint blocks of a quantum critical system, to show that the structure of the causal cones characteristic of MERA, requires a transition between two different regimes attainable by changing the ratio between the size and the separation of the two disjoint blocks. We argue that this transition in the MERA causal developments of the blocks may be easily accounted by an AdS d+2 black hole geometry when the mutual information is computed using the Ryu-Takayanagi formula. As an explicit example, we use a BTZ AdS3 black hole to compute the MI and the quantum correlations between two disjoint intervals of a one dimensional boundary critical system. Our results for this low dimensional system not only show the existence of a phase transition emerging when the conformal four point ratio reaches a critical value but also provide an intuitive entropic argument accounting for the source of this instability. We discuss the robustness of this transition when finite temperature and finite size effects are taken into account.

  8. Utilization of excitation signal harmonics for control of nonlinear systems

    DEFF Research Database (Denmark)

    Vinther, Kasper; Rasmussen, Henrik; Izadi-Zamanabadi, Roozbeh;

    2012-01-01

    signal together with Fourier analysis to generate a feedback signal and simulations have shown that different system gains and time constants does not change the global equilibrium/operating point. An evaporator in a refrigeration system was used as example in the simulations, however, it is anticipated...

  9. Low-Overhead Non-Blocking Checkpointing Scheme for Mobile Computing Systems

    Institute of Scientific and Technical Information of China (English)

    MEN Chaoguang; CAO Liujuan; WANG Liwen; XU Zhenpeng

    2007-01-01

    When applied to mobile computing systems, checkpoint protocols for distributed computing systems would face many new challenges, such as low wireless bandwidth, frequent disconnections, and lack of stable storage at mobile hosts. This paper proposes a novel checkpoint protocol to effectively reduce the coordinating overhead. By using a communication vector, only a few processes participate in the checkpointing event. During checkpointing, the scheme can save the time used to trace the dependency tree by sending checkpoint requests to dependent processes at once. In addition, processes are non-blocking in this scheme, since the inconsistency is resolved by the piggyback technique. Hence the unnecessary and orphan messages can be avoided. Compared with the traditional coordinated checkpoint approach, the proposed non-blocking algorithm obtains a minimal number of processes to take checkpoints. It also reduces the checkpoint latency, which brings less overhead to mobile host with limited resources.

  10. An Optimization Approach for Selecting Blocks of Embedding Process in Robust Watermarking System

    Directory of Open Access Journals (Sweden)

    Ababneh M.F. Mohammad

    2006-01-01

    Full Text Available This study, discusses several kinds of attacks that may meet the watermarked image such as JPEG compression, Gaussian noise and median filter. The study introduces an approach capable of selecting the optimal blocks in cover image to be used in embedding process. Also, in this study, we propose a technique in robust digital watermarking system looking for finding a relation between the contrast of cover image and robustness to increase the resistance of previous attacks.

  11. Evaluated phase diagrams of binary metal-tellurium systems of the D-block transition elements

    International Nuclear Information System (INIS)

    The binary phase diagrams of metal-tellurium systems for twenty seven d-block transition elements have been critically evaluated. Complete phase diagrams are presented for the elements, chromium, manganese, iron, cobalt, nickel, copper, molybdenum, palladium, silver, lanthanum, platinum and gold, whereas, for scandium, titanium, vanadium, yttrium, zirconium, niobium, technitium, ruthenium, rhodium, hafnium, tantalum, tungsten , rhenium, osmium and iridium, the phase diagrams are incomplete and tentative. (author). 20 refs., 27 tabs., 27 figs

  12. Security Analysis of a Block Encryption Algorithm Based on Dynamic Sequences of Multiple Chaotic Systems

    Institute of Scientific and Technical Information of China (English)

    DU Mao-Kang; HE Bo; WANG Yong

    2011-01-01

    Recently, the cryptosystem based on chaos has attracted much attention. Wang and Yu (Commun. Nonlin. Sci. Numer. Simulat. 14(2009)574) proposed a block encryption algorithm based on dynamic sequences of multiple chaotic systems. We analyze the potential Saws in the algorithm. Then, a chosen-plaintext attack is presented. Some remedial measures are suggested to avoid the flaws effectively. Furthermore, an improved encryption algorithm is proposed to resist the attacks and to keep all the merits of the original cryptosystem.

  13. Developing the basic building blocks of mathematics to be employed in practical embedded systems

    Energy Technology Data Exchange (ETDEWEB)

    Tickle, A J; Harvey, P K; Smith, J S [Intelligence Engineering and Industrial Automation Research Group, Department of Electrical Engineering and Electronics, The University of Liverpool, Liverpool L69 3GJ (United Kingdom); Wu, F, E-mail: a.j.tickle@liverpool.ac.u [RF Engines Ltd, Innovation Centre, St. Cross Business Park, Newport, Isle of Wight, PO30 5WB (United Kingdom)

    2009-07-01

    Mathematics is vitally important as it is used in many areas of science and engineering, in particular are functions such as sine, cosine and the exponent in addition to being to able to carry out such tasks as decimal division. The sine wave is vitally important in physics and communications due to its ability to retain its waveshape when added to another sine wave of the same frequency and arbitrary phase. It is the only periodic waveform that has this property and leads to techniques such as Fourier analysis. Unfortunately these blocks are not included in the standard DSP Builder blockset in Simulink and so a method of creating these operations must be created if this methodology is to be employed in real world tasks such as power relay protection and stereo vision systems. Shown here is a method of performing these calculations using the limited blocks provided for a 50-bit based embedded system with a discussion about the accuracy when compared to traditional digital system counterparts. The order of the equations used and the scaling factors of the blocks are investigated to provide evidence of why certain values need to be changed depending upon the calculation being performed.

  14. The C proteins of human parainfluenza virus type 1 block IFN signaling by binding and retaining Stat1 in perinuclear aggregates at the late endosome.

    Directory of Open Access Journals (Sweden)

    Henrick Schomacker

    Full Text Available Interferons (IFNs play a crucial role in the antiviral immune response. Whereas the C proteins of wild-type human parainfluenza virus type 1 (WT HPIV1 inhibit both IFN-β induction and signaling, a HPIV1 mutant encoding a single amino acid substitution (F170S in the C proteins is unable to block either host response. Here, signaling downstream of the type 1 IFN receptor was examined in Vero cells to define at what stage WT HPIV1 can block, and F170S HPIV1 fails to block, IFN signaling. WT HPIV1 inhibited phosphorylation of both Stat1 and Stat2, and this inhibition was only slightly reduced for F170S HPIV1. Degradation of Stat1 or Stat2 was not observed. The HPIV1 C proteins were found to accumulate in the perinuclear space, often forming large granules, and co-localized with Stat1 and the cation-independent mannose 6-phosphate receptor (M6PR that is a marker for late endosomes. Upon stimulation with IFN-β, both the WT and F170S C proteins remained in the perinuclear space, but only the WT C proteins prevented Stat1 translocation to the nucleus. In addition, WT HPIV1 C proteins, but not F170S C proteins, co-immunoprecipitated both phosphorylated and unphosphorylated Stat1. Our findings suggest that the WT HPIV1 C proteins form a stable complex with Stat1 in perinuclear granules that co-localize with M6PR, and that this direct interaction between the WT HPIV1 C proteins and Stat1 is the basis for the ability of HPIV1 to inhibit IFN signaling. The F170S mutation in HPIV1 C did not prevent perinuclear co-localization with Stat1, but apparently weakened this interaction such that, upon IFN stimulation, Stat1 was translocated to the nucleus to induce an antiviral response.

  15. Theory for dynamical self arrest and gelation in microemulsions and the block copolymer systems

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Sangwook [Iowa State Univ., Ames, IA (United States)

    2005-01-01

    The main purpose of this work is to investigate the glassy behavior of microemulsions and block copolymers. The origin of glassy behavior in microemulsions and block copolymers is frustration due to a competition between short-range interaction and long range interaction. According to the charge frustrated Ising model, the competition between ferromagnetic interaction and antiferromagnetic interaction is the origin of frustration in microemulsions. The competition between entropic effects and stoichiometric constraints responsible for the formation of micelles in microemulsions can lead to the emergence of a self generated glassy behavior in these systems. In the block copolymer, the competition between the repulsive short range interaction between monomers in polymer chains and the long range interaction by chemical bonds can lead to the emergence of a self generated glassy behavior. The criteria for the fluctuation induced first order transition and our microemulsion and block copolymer glasses are essentially the same. Both are a consequence of the large phase space of low energy excitations (14) (62) (all states with momenta q which fulfill |q| = qm) and are of at the most a moderate supercooling of the liquid state is required. This is strongly supported by the observation in Ref. (14) that the metastable states which are first to appear at a fluctuation induced first order transition are the ones build by a superposition of large amplitude waves of wavenumber qm, but with random orientations and phases, i.e. just the ones which form the metastable states of our microemulsion and block copolymer glass. (38)

  16. Theory for dynamical self arrest and gelation in microemulsions and the block copolymer systems

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Sangwook

    2005-05-01

    The main purpose of this work is to investigate the glassy behavior of microemulsions and block copolymers. The origin of glassy behavior in microemulsions and block copolymers is frustration due to a competition between short-range interaction and long range interaction. According to the charge frustrated Ising model, the competition between ferromagnetic interaction and antiferromagnetic interaction is the origin of frustration in microemulsions. The competition between entropic effects and stoichiometric constraints responsible for the formation of micelles in microemulsions can lead to the emergence of a self generated glassy behavior in these systems. In the block copolymer, the competition between the repulsive short range interaction between monomers in polymer chains and the long range interaction by chemical bonds can lead to the emergence of a self generated glassy behavior. The criteria for the fluctuation induced first order transition and our microemulsion and block copolymer glasses are essentially the same. Both are a consequence of the large phase space of low energy excitations (14) (62) (all states with momenta q which fulfill |q| = q{sub m}) and are of at the most a moderate supercooling of the liquid state is required. This is strongly supported by the observation in Ref. (14) that the metastable states which are first to appear at a fluctuation induced first order transition are the ones build by a superposition of large amplitude waves of wavenumber q{sub m}, but with random orientations and phases, i.e. just the ones which form the metastable states of our microemulsion and block copolymer glass. (38)

  17. Ground standoff mine detection system (GSTAMIDS) engineering, manufacturing, and development (EMD) Block 0

    Science.gov (United States)

    Pressley, Jackson R.; Pabst, Donald; Sower, Gary D.; Nee, Larry; Green, Brian; Howard, Peter

    2001-10-01

    The United States Army has contracted EG&G Technical Services to build the GSTAMIDS EMD Block 0. This system autonomously detects and marks buried anti-tank land mines from an unmanned vehicle. It consists of a remotely operated host vehicle, standard teleoperation system (STS) control, mine detection system (MDS) and a control vehicle. Two complete systems are being fabricated, along with a third MDS. The host vehicle for Block 0 is the South African Meerkat that has overpass capability for anti-tank mines, as well as armor anti-mine blast protection and ballistic protection. It is operated via the STS radio link from within the control vehicle. The Main Computer System (MCS), located in the control vehicle, receives sensor data from the MDS via a high speed radio link, processes and fuses the data to make a decision of a mine detection, and sends the information back to the host vehicle for a mark to be placed on the mine location. The MCS also has the capability to interface into the FBCB2 system via SINGARS radio. The GSTAMIDS operator station and the control vehicle communications system also connect to the MCS. The MDS sensors are mounted on the host vehicle and include Ground Penetrating Radar (GPR), Pulsed Magnetic Induction (PMI) metal detector, and (as an option) long-wave infrared (LWIR). A distributed processing architecture is used so that pre-processing is performed on data at the sensor level before transmission to the MCS, minimizing required throughput. Nine (9) channels each of GPR and PMI are mounted underneath the meerkat to provide a three-meter detection swath. Two IR cameras are mounted on the upper sides of the Meerkat, providing a field of view of the required swath with overlap underneath the vehicle. Also included on the host vehicle are an Internal Navigation System (INS), Global Positioning System (GPS), and radio communications for remote control and data transmission. The GSTAMIDS Block 0 is designed as a modular, expandable system

  18. A New Indoor Positioning System Architecture Using GPS Signals

    Science.gov (United States)

    Xu, Rui; Chen, Wu; Xu, Ying; Ji, Shengyue

    2015-01-01

    The pseudolite system is a good alternative for indoor positioning systems due to its large coverage area and accurate positioning solution. However, for common Global Positioning System (GPS) receivers, the pseudolite system requires some modifications of the user terminals. To solve the problem, this paper proposes a new pseudolite-based indoor positioning system architecture. The main idea is to receive real-world GPS signals, repeat each satellite signal and transmit those using indoor transmitting antennas. The transmitted GPS-like signal can be processed (signal acquisition and tracking, navigation data decoding) by the general receiver and thus no hardware-level modification on the receiver is required. In addition, all Tx can be synchronized with each other since one single clock is used in Rx/Tx. The proposed system is simulated using a software GPS receiver. The simulation results show the indoor positioning system is able to provide high accurate horizontal positioning in both static and dynamic situations. PMID:25938199

  19. Resveratrol inhibits enterovirus 71 replication and pro-inflammatory cytokine secretion in rhabdosarcoma cells through blocking IKKs/NF-κB signaling pathway.

    Directory of Open Access Journals (Sweden)

    Li Zhang

    Full Text Available Polydatin and resveratrol, as major active components in Polygonum cuspidatum, have anti-inflammatory, antioxidant and antitumor functions. However, the effect and mechanism of polydatin and resveratrol on enterovirus 71 (EV71 have not been reported. In this study, resveratrol revealed strong antiviral activity on EV71, while polydatin had weak effect. Neither polydatin nor resveratrol exhibited influence on viral attachment. Resveratrol could effectively inhibit the synthesis of EV71/VP1 and the phosphorylation of IKKα, IKKβ, IKKγ, IKBα, NF-κB p50 and NF-κB p65, respectively. Meanwhile, the remarkably increased secretion of IL-6 and TNF-α in EV71-infected rhabdosarcoma (RD cells could be blocked by resveratrol. These results demonstrated that resveratrol inhibited EV71 replication and cytokine secretion in EV71-infected RD cells through blocking IKKs/NF-κB signaling pathway. Thus, resveratrol may have potent antiviral effect on EV71 infection.

  20. Goldstone solar system radar signal processing

    Science.gov (United States)

    Jurgens, R. F.; Satorius, E.; Sanchez, O.

    1992-01-01

    A performance analysis of the planetary radar data acquisition system is presented. These results extend previous computer simulation analysis and are facilitated by the development of a simple analytical model that predicts radar system performance over a wide range of operational parameters. The results of this study are useful to both the radar systems designer and the science investigator in establishing operational radar data acquisition parameters which result in the best systems performance for a given set of input conditions.

  1. Signal processing methods for PWR reactor noise diagnostic system

    International Nuclear Information System (INIS)

    A framework for a PWR reactor noise diagnostic system using various signal processing methods has been investigated. Supposing to treat not only reactor noise data in a stationary linear system but also those in a nonstationary or nonlinear system, the study covers a third-order-correlation of bispectrum, cepstrum analysis, Group Method of Data Handling (GMDH), chaotic quantity, neural network, and wavelet, in addition to Multivariate AutoRegressive analysis and Signal Transmission Path Diagram analysis (MAR/STPD). This paper describes consideration about the methods from viewpoints of theories and applications to PWR reactor noise diagnostic system. The point at the issue in the application system is how to extract many characteristics from the signals whatever states (linear or nonlinear, stationary or nonstationary) may happen in order to get more information and more exact diagnose to support human judgment. From this viewpoint, the paper discusses several signal processing techniques for the PWR diagnostic system. (J.P.N.)

  2. COMPUTER-BASED ECG SIGNAL ANALYSIS AND MONITORING SYSTEM

    Directory of Open Access Journals (Sweden)

    Nasser N. Khamiss Al-Ani

    2008-01-01

    Full Text Available This paper deals with the design and implementation of an ECG system. The proposed system gives a new concept of ECG signal manipulation, storing, and editing. It consists mainly of hardware circuits and the related software. The hardware includes the circuits of ECG signals capturing, and system interfaces. The software is written using Visual Basic languages, to perform the task of identification of the ECG signal. The main advantage of the system is to provide a reported ECG recording on a personal computer, so that it can be stored and processed at any time as required. This system was tested for different ECG signals, some of them are abnormal and the other is normal, and the results show that the system has a good quality of diagnosis identification.

  3. Signals, processes, and systems an interactive multimedia introduction to signal processing

    CERN Document Server

    Karrenberg, Ulrich

    2013-01-01

    This is a very new concept for learning Signal Processing, not only from the physically-based scientific fundamentals, but also from the didactic perspective, based on modern results of brain research. The textbook together with the DVD form a learning system that provides investigative studies and enables the reader to interactively visualize even complex processes. The unique didactic concept is built on visualizing signals and processes on the one hand, and on graphical programming of signal processing systems on the other. The concept has been designed especially for microelectronics, computer technology and communication. The book allows to develop, modify, and optimize useful applications using DasyLab - a professional and globally supported software for metrology and control engineering. With the 3rd edition, the software is also suitable for 64 bit systems running on Windows 7. Real signals can be acquired, processed and played on the sound card of your computer. The book provides more than 200 pre-pr...

  4. Modelling of composite concrete block pavement systems applying a cohesive zone model

    DEFF Research Database (Denmark)

    Skar, Asmus; Poulsen, Peter Noe

    This paper presents a numerical analysis of the fracture behaviour of the cement bound base material in composite concrete block pavement systems, using a cohesive zone model. The functionality of the proposed model is tested on experimental and numerical investigations of beam bending tests...... that the cohesive model is suitable for simulation of crack propagation in cement bound materials subjected to monotonic loading. The methodology implemented gives a new understanding of the mechanical behaviour of cement bound materials which can be used in further refinements of mechanical models for composite...... block pavements. It is envisaged that the methodology implemented in this study can be extended and thereby contribute to the ongoing development of rational failure criteria that can replace the empirical formulas currently used in pavement engineering....

  5. Block preconditioners for linear systems arising from multiscale collocation with compactly supported RBFs

    KAUST Repository

    Farrell, Patricio

    2015-04-30

    © 2015John Wiley & Sons, Ltd. Symmetric collocation methods with RBFs allow approximation of the solution of a partial differential equation, even if the right-hand side is only known at scattered data points, without needing to generate a grid. However, the benefit of a guaranteed symmetric positive definite block system comes at a high computational cost. This cost can be alleviated somewhat by considering compactly supported RBFs and a multiscale technique. But the condition number and sparsity will still deteriorate with the number of data points. Therefore, we study certain block diagonal and triangular preconditioners. We investigate ideal preconditioners and determine the spectra of the preconditioned matrices before proposing more practical preconditioners based on a restricted additive Schwarz method with coarse grid correction. Numerical results verify the effectiveness of the preconditioners.

  6. Block Krylov subspace exact time integration of linear ODE systems. Part 1: algorithm description

    CERN Document Server

    Botchev, Mikhail A

    2011-01-01

    We propose a time-exact Krylov-subspace-based method for solving linear ODE (ordinary differential equation) systems of the form $y'=-Ay + g(t)$, where $y(t)$ is the unknown function. The method consists of two stages. The first stage is an accurate polynomial approximation of the source term $g(t)$, constructed with the help of the truncated SVD (singular value decomposition). The second stage is a special residual-based block Krylov subspace method. The accuracy of the method is only restricted by the accuracy of the polynomial approximation and by the error of the block Krylov process. Since both errors can, in principle, be made arbitrarily small, this yields, at some costs, a time-exact method.

  7. Volume shrinkage and rheological studies of epoxidised and unepoxidised poly(styrene-block-butadiene-block-styrene) triblock copolymer modified epoxy resin-diamino diphenyl methane nanostructured blend systems.

    Science.gov (United States)

    George, Sajeev Martin; Puglia, Debora; Kenny, Josè M; Parameswaranpillai, Jyotishkumar; Vijayan P, Poornima; Pionteck, Jűrgen; Thomas, Sabu

    2015-05-21

    Styrene-block-butadiene-block-styrene (SBS) copolymers epoxidised at different epoxidation degrees were used as modifiers for diglycidyl ether of the bisphenol A-diamino diphenyl methane (DGEBA-DDM) system. Epoxy systems containing modified epoxidised styrene-block-butadiene-block-styrene (eSBS) triblock copolymer with compositions ranging from 0 to 30 wt% were prepared and the curing reaction was monitored in situ using rheometry and pressure-volume-temperature (PVT) analysis. By controlling the mole percent of epoxidation, we could generate vesicles, worm-like micelles and core-shell nanodomains. At the highest mole percent of epoxidation, the fraction of the epoxy miscible component in the triblock copolymer (epoxidised polybutadiene (PB)) was maximum. This gave rise to core-shell nanodomains having a size of 10-15 nm, in which the incompatible polystyrene (PS) becomes the core, the unepoxidised PB becomes the shell and the epoxidised PB interpenetrates with the epoxy phase. On the other hand, the low level of epoxidation gave rise to bigger domains having a size of ∼1 μm and the intermediate epoxidation level resulted in a worm-like structure. This investigation specifically focused on the importance of cure rheology on nanostructure formation, using rheometry. The reaction induced phase separation of the PS phase in the epoxy matrix was carefully explored through rheological measurements. PVT measurements during curing were carried out to understand the volume shrinkage of the blend, confirming that shrinkage behaviour is related to the block copolymer phase separation process during curing. The volume shrinkage was found to be maximum in the case of blends with unmodified SBS, where a heterogeneous morphology was observed, while a decrease in the shrinkage was evidenced in the case of SBS epoxidation. It could be explained by two effects: (1) solubility of the epoxidised block copolymer in the DGEBA leads to the formation of nanoscopic domains upon

  8. Flash signal evolution in Photinus fireflies: character displacement and signal exploitation in a visual communication system.

    Science.gov (United States)

    Stanger-Hall, Kathrin F; Lloyd, James E

    2015-03-01

    Animal communication is an intriguing topic in evolutionary biology. In this comprehensive study of visual signal evolution, we used a phylogenetic approach to study the evolution of the flash communication system of North American fireflies. The North American firefly genus Photinus contains 35 described species with simple ON-OFF visual signals, and information on habitat types, sympatric congeners, and predators. This makes them an ideal study system to test hypotheses on the evolution of male and female visual signal traits. Our analysis of 34 Photinus species suggests two temporal pattern generators: one for flash duration and one for flash intervals. Reproductive character displacement was a main factor for signal divergence in male flash duration among sympatric Photinus species. Male flash pattern intervals (i.e., the duration of the dark periods between signals) were positively correlated with the number of sympatric Photuris fireflies, which include predators of Photinus. Females of different Photinus species differ in their response preferences to male traits. As in other communication systems, firefly male sexual signals seem to be a compromise between optimizing mating success (sexual selection) and minimizing predation risk (natural selection). An integrative model for Photinus signal evolution is proposed.

  9. Signal processing method and system for noise removal and signal extraction

    Science.gov (United States)

    Fu, Chi Yung; Petrich, Loren

    2009-04-14

    A signal processing method and system combining smooth level wavelet pre-processing together with artificial neural networks all in the wavelet domain for signal denoising and extraction. Upon receiving a signal corrupted with noise, an n-level decomposition of the signal is performed using a discrete wavelet transform to produce a smooth component and a rough component for each decomposition level. The n.sup.th level smooth component is then inputted into a corresponding neural network pre-trained to filter out noise in that component by pattern recognition in the wavelet domain. Additional rough components, beginning at the highest level, may also be retained and inputted into corresponding neural networks pre-trained to filter out noise in those components also by pattern recognition in the wavelet domain. In any case, an inverse discrete wavelet transform is performed on the combined output from all the neural networks to recover a clean signal back in the time domain.

  10. Simulation of queue with cyclic service in signalized intersection system

    Directory of Open Access Journals (Sweden)

    Muhammad Dermawan Mulyodiputro

    2015-03-01

    Full Text Available The simulation was implemented by modeling the queue with cyclic service in the signalized intersection system. The service policies used in this study were exhaustive and gated, the model was the M/M/1 queue, the arrival rate used was Poisson distribution and the services rate used was Exponential distribution. In the gated service policy, the server served only vehicles that came before the green signal appears at an intersection. Considered that there were 2 types of exhaustive policy in the signalized intersection system, namely normal exhaustive (vehicles only served during the green signal was still active, and exhaustive (there was the green signal duration addition at the intersection, when the green signal duration at an intersection finished. The results of this queueing simulation program were to obtain characteristics and performance of the system, i.e. average number of vehicles and waiting time of vehicles in the intersection and in the system, as well as system utilities. Then from these values, it would be known which of the cyclic service policies (normal exhaustive, exhaustive and gated was the most suitable when applied to a signalized intersection system

  11. Signal restoration in intensity-modulated optical OFDM access systems.

    Science.gov (United States)

    Vanin, Evgeny

    2011-11-15

    It is well known that deliberate signal clipping in an intensity-modulated (IM) laser transmitter helps to overcome the optical orthogonal frequency division multiplexing (OFDM) system performance limitation that is related to the signal high peak-to-average power ratio. The amplitude of a clipped OFDM signal has to be optimized in order to minimize the optical power that is required to achieve a specified system performance. However, the signal clipping introduces nonlinear distortion (so-called clipping noise) and leads to a system performance penalty. In this Letter, the performance of the IM optical OFDM system with digital baseband clipping distortion in the transmitter and clipping noise compensation by means of signal restoration in the digital signal processing unit of the system receiver is analytically evaluated. It is demonstrated that the system bit-error ratio can be reduced by more than an order of magnitude, from 10(-3) to 3.5×10(-5), by applying only the first iteration of the signal restoration algorithm proposed in this Letter. The results of the analytical analysis are verified with brute-force numerical simulations based on direct error counting. PMID:22089556

  12. Measurement System for Playout Delay of TV Signals

    NARCIS (Netherlands)

    Kooij, W.J.; Stokking, H.M.; Brandenburg, R. van; Boer, P.T. de

    2014-01-01

    TV signals are carried towards end-users using different (broadcast) technologies and by different providers. This is causing differences in the playout timing of the TV signal at different locations and devices. Authors have developed a measurement system for measuring the relative playout delay of

  13. Auditory signal design for automatic number plate recognition system

    NARCIS (Netherlands)

    Heydra, C.G.; Jansen, R.J.; Van Egmond, R.

    2014-01-01

    This paper focuses on the design of an auditory signal for the Automatic Number Plate Recognition system of Dutch national police. The auditory signal is designed to alert police officers of suspicious cars in their proximity, communicating priority level and location of the suspicious car and takin

  14. Power system small signal stability analysis and control

    CERN Document Server

    Mondal, Debasish; Sengupta, Aparajita

    2014-01-01

    Power System Small Signal Stability Analysis and Control presents a detailed analysis of the problem of severe outages due to the sustained growth of small signal oscillations in modern interconnected power systems. The ever-expanding nature of power systems and the rapid upgrade to smart grid technologies call for the implementation of robust and optimal controls. Power systems that are forced to operate close to their stability limit have resulted in the use of control devices by utility companies to improve the performance of the transmission system against commonly occurring power system

  15. BLOCK CODING SCHEME FOR REDUCING PAPR IN OFDM SYSTEMS WITH LARGE NUMBER OF SUBCARRIERS

    Institute of Scientific and Technical Information of China (English)

    Jiang Tao; Zhu Guangxi; Zheng Jianbin

    2004-01-01

    The major drawback in Orthogonal Frequency Division Multiplexing (OFDM) system is due to the high Peak-to-Average Power Ratio (PAPR), so the performance of the system is significantly degraded by the nonlinearity of a High Power Amplifier (HPA) in the transmitter.In order to mitigate distortion, a block coding scheme for reducing PAPR in OFDM systems with large number of subcarriers based on complementary sequences and predistortion is proposed,which is capable of both error correction and PAPR reduction. Computer simulation results show that the proposed scheme significantly improves Bit Error Rate(BER) performance as compared to an uncoded system when an HPA is employed or a coded system without predistortion.

  16. The BTK Inhibitor Ibrutinib (PCI-32765) Blocks Hairy Cell Leukaemia Survival, Proliferation and BCR Signalling: A New Therapeutic Approach

    OpenAIRE

    Sivina, Mariela; Kreitman, Robert J.; Arons, Evgeny; Ravandi, Farhad; Burger, Jan A.

    2014-01-01

    B cell receptor (BCR) signalling plays a critical role in the progression of several B-cell malignancies, but its role in hairy cell leukaemia (HCL) is ambiguous. Bruton tyrosine kinase (BTK), a key player in BCR signalling, migration and adhesion, can be targeted with ibrutinib, a selective, irreversible BTK inhibitor. We analysed BTK expression and function in HCL and analysed the effects of ibrutinib on HCL cells. We demonstrated uniform BTK protein expression in HCL cells. Ibrutinib signi...

  17. Targeting the PDGF-B/PDGFR-β Interface with Destruxin A5 to Selectively Block PDGF-BB/PDGFR-ββ Signaling and Attenuate Liver Fibrosis

    Directory of Open Access Journals (Sweden)

    Xingqi Wang

    2016-05-01

    Full Text Available PDGF-BB/PDGFR-ββ signaling plays very crucial roles in the process of many diseases such as liver fibrosis. However, drug candidates with selective affinities for PDGF-B/PDGFR-β remain deficient. Here, we identified a natural cyclopeptide termed destruxin A5 that effectively inhibits PDGF-BB-induced PDGFR-β signaling. Interestingly and importantly, the inhibitory mechanism is distinct from the mechanism of tyrosine kinase inhibitors because destruxin A5 does not have the ability to bind to the ATP-binding pocket of PDGFR-β. Using Biacore T200 technology, thermal shift technology, microscale thermophoresis technology and computational analysis, we confirmed that destruxin A5 selectively targets the PDGF-B/PDGFR-β interaction interface to block this signaling. Additionally, the inhibitory effect of destruxin A5 on PDGF-BB/PDGFR-ββ signaling was verified using in vitro, ex vivo and in vivo models, in which the extent of liver fibrosis was effectively alleviated by destruxin A5. In summary, destruxin A5 may represent an efficacious and more selective inhibitor of PDGF-BB/PDGFR-ββ signaling.

  18. Improvement of train transportation performance by convoy signaling

    Science.gov (United States)

    Zhao, Yingbo; Orlik, Philip; Parsons, Kieran; Kataoka, Kenji; Kalmar-Nagy, Tamas

    2016-02-01

    In this paper, we compare the transportation performance of a given railway for three types of signaling system: fixed-block signaling, moving-block signaling and train-convoy signaling. The transportation performance is evaluated from two aspects: track capacity and robustness to delays. The transportation performance is computed using numerical method and a new cellular automaton model is proposed to simulate the behavior of a train. The simulation results show that train-convoy signaling can improve track capacity and robustness to delays, at the same time, compared to fixed-block signaling and moving-block signaling.

  19. Noise Separation from the Weak Signal Chaotic Detection System

    Directory of Open Access Journals (Sweden)

    Hanjie Gu

    2014-11-01

    Full Text Available The traditional weak signal chaotic detection system still restricts some technical issues in the situation of the signal with noise, such as poor denoising ability and low detection precision. In this paper, we propose a novel weak signal chaotic detection system based on an improved wavelet transform algorithm. First, the traditional wavelet transform algorithm domain variables have been transformed and discretized to eliminate the redundant transform. Then, based on the discrete optimization, the wavelet coefficients have been optimized by threshold compromise strategy. The improved wavelet transform algorithm is applied in the weak signal chaotic detection system. The noise signal after finite discrete processing is treated as a perturbation of cycle power and put into a chaotic system for detecting weak signal under the noise conditions. The simulation experiments show that the proposed improved wavelet transform algorithm has a better denoising effect than the traditional wavelet transform algorithm. Moreover, the improved algorithm shows better accuracy and higher robustness in the weak signal chaotic detection system.

  20. A Radio Communication System for Neuronal Signals

    Institute of Scientific and Technical Information of China (English)

    Wang Min; Yang Maoquan; Wang Xiaojun; Guang Kui; Zhang Xiao

    2012-01-01

    To collect neuronal activity data from awake, freely behaving animals, we developed miniature telemetry recording system. The integrated system consists of four major components: l) Microelectrodes and micro-driver assembly, 2) analog front end (AFE), 3) programmable system on chip (PSoC), and 4) ra- dio transceiver and the LabVIEW were used as a platform for the graphic user interface. The result showed the system was able to record and analyze neuronal recordings in freely moving animals and lasted continuously for a time period of a week or more. This is very useful for the study of the interdisciplinary research of neu- roscience and information engineering techniques. The circuits and architecture of the devices can be adapted for neurobiology and research with other small animals.

  1. The design and implementation of signal decomposition system of CL multi-wavelet transform based on DSP builder

    Science.gov (United States)

    Huang, Yan; Wang, Zhihui

    2015-12-01

    With the development of FPGA, DSP Builder is widely applied to design system-level algorithms. The algorithm of CL multi-wavelet is more advanced and effective than scalar wavelets in processing signal decomposition. Thus, a system of CL multi-wavelet based on DSP Builder is designed for the first time in this paper. The system mainly contains three parts: a pre-filtering subsystem, a one-level decomposition subsystem and a two-level decomposition subsystem. It can be converted into hardware language VHDL by the Signal Complier block that can be used in Quartus II. After analyzing the energy indicator, it shows that this system outperforms Daubenchies wavelet in signal decomposition. Furthermore, it has proved to be suitable for the implementation of signal fusion based on SoPC hardware, and it will become a solid foundation in this new field.

  2. Immune System to Brain Signaling: Neuropsychopharmacological Implications

    OpenAIRE

    Capuron, Lucile; Miller, Andrew H.

    2011-01-01

    There has been an explosion in our knowledge of the pathways and mechanisms by which the immune system can influence the brain and behavior. In the context of inflammation, pro-inflammatory cytokines can access the central nervous system and interact with a cytokine network in the brain to influence virtually every aspect of brain function relevant to behavior including neurotransmitter metabolism, neuroendocrine function, synaptic plasticity, and neurocircuits that regulate mood, motor activ...

  3. Modelling of Signal - Level Crossing System

    Directory of Open Access Journals (Sweden)

    Daniel Novak

    2006-01-01

    Full Text Available The author presents an object-oriented model of a railway level-crossing system created for the purpose of functional requirements specification. Unified Modelling Language (UML, version 1.4, which enables specification, visualisation, construction and documentation of software system artefacts, was used. The main attention was paid to analysis and design phases. The former phase resulted in creation of use case diagrams and sequential diagrams, the latter in creation of class/object diagrams and statechart diagrams.

  4. An implantable CMOS signal conditioning system for recording nerve signals with cuff electrodes

    DEFF Research Database (Denmark)

    Papathanasiou, Konstantinos; Lehmann, Torsten

    2000-01-01

    We propose a system architecture for recording nerve signals with cuff electrodes and develop the key component in this system, the small-input, low-noise, low-power, high-gain amplifier. The amplifier is implemented using a mixture of weak- and strong-inversion transistors and a special off-set ......-set compensation technique; its performance is validated using Spice simulations....

  5. Holographic View on Quantum Correlations and Mutual Information between Disjoint Blocks of a Quantum Critical System

    CERN Document Server

    Molina-Vilaplana, Javier

    2011-01-01

    We exploit the Multiscale Entanglement Renormalization Ansatz (MERA) to explicitly build the bulk AdSd+2 space associated to a (d+1) dimensional conformal field theory describing a critical system lying at the boundary of the AdS space. We show that, when computing the quantum correlations between two disjoint blocks of the boundary critical system, the structure of the causal cones characteristic of MERA requires a transition between two different regimes attainable by changing the ratio between the size and the separation of the two disjoint blocks. We argue that this transition may be easily accounted for if the metric of the MERA induced holographic dual bulk spacetime is described by an AdSd+2 black hole and the mutual information is computed using the Ryu-Takayanagi formula. As an explicit example, we use a BTZ AdS3 black hole to compute the MI and the quantum correlations between two disjoint intervals of a one dimensional boundary critical system. Our results for this low dimensional system not only s...

  6. Biophysics and Thermodynamics: The Scientific Building Blocks of Bio-inspired Drug Delivery Nano Systems.

    Science.gov (United States)

    Demetzos, Costas

    2015-06-01

    Biophysics and thermodynamics are considered as the scientific milestones for investigating the properties of materials. The relationship between the changes of temperature with the biophysical variables of biomaterials is important in the process of the development of drug delivery systems. Biophysics is a challenge sector of physics and should be used complementary with the biochemistry in order to discover new and promising technological platforms (i.e., drug delivery systems) and to disclose the 'silence functionality' of bio-inspired biological and artificial membranes. Thermal analysis and biophysical approaches in pharmaceuticals present reliable and versatile tools for their characterization and for the successful development of pharmaceutical products. The metastable phases of self-assembled nanostructures such as liposomes should be taken into consideration because they represent the thermal events can affect the functionality of advanced drug delivery nano systems. In conclusion, biophysics and thermodynamics are characterized as the building blocks for design and development of bio-inspired drug delivery systems.

  7. Water distributions in polystyrene-block-poly[styrene-g-poly(ethylene oxide)] block grafted copolymer system in aqueous solutions revealed by contrast variation small angle neutron scattering study

    Science.gov (United States)

    Li, Xin; Hong, Kunlun; Liu, Yun; Shew, Chwen-Yang; Liu, Emily; Herwig, Kenneth W.; Smith, Gregory S.; Zhao, Junpeng; Zhang, Guangzhao; Pispas, Stergios; Chen, Wei-Ren

    2010-10-01

    We develop an experimental approach to analyze the water distribution around a core-shell micelle formed by polystyrene-block-poly[styrene-g-poly(ethylene oxide (PEO)] block copolymers in aqueous media at a fixed polymeric concentration of 10 mg/ml through contrast variation small angle neutron scattering (SANS) study. Through varying the D2O/H2O ratio, the scattering contributions from the water molecules and the micellar constituent components can be determined. Based on the commonly used core-shell model, a theoretical coherent scattering cross section incorporating the effect of water penetration is developed and used to analyze the SANS I(Q ). We have successfully quantified the intramicellar water distribution and found that the overall micellar hydration level increases with the increase in the molecular weight of hydrophilic PEO side chains. Our work presents a practical experimental means for evaluating the intramacromolecular solvent distributions of general soft matter systems.

  8. 4th International Conference on Communications, Signal Processing, and Systems

    CERN Document Server

    Mu, Jiasong; Wang, Wei; Zhang, Baoju

    2016-01-01

    This book brings together papers presented at the 4th International Conference on Communications, Signal Processing, and Systems, which provides a venue to disseminate the latest developments and to discuss the interactions and links between these multidisciplinary fields. Spanning topics ranging from Communications, Signal Processing and Systems, this book is aimed at undergraduate and graduate students in Electrical Engineering, Computer Science and Mathematics, researchers and engineers from academia and industry as well as government employees (such as NSF, DOD, DOE, etc).

  9. Biometric recognition system using low bandwidth ECG signals

    OpenAIRE

    Matos, André Cigarro; Lourenço, André Ribeiro; Nascimento, José M. P.

    2013-01-01

    Biometric recognition has recently emerged as part of applications where the privacy of the information is crucial, as in the health care field. This paper presents a biometric recognition system based on the Electrocardiographic signal (ECG). The proposed system is based on a state-of-the-art recognition method which extracts information from the frequency domain. In this paper we propose a new method to increase the spectral resolution of low bandwidth ECG signals due to the limited bandwid...

  10. OUTPUT FEEDBACK CONTROL FOR MIMO NONLINEAR SYSTEMS WITH EXOGENOUS SIGNALS

    Institute of Scientific and Technical Information of China (English)

    Ying ZHOU; Yuqiang WU

    2006-01-01

    The paper addresses the global output tracking of a class of multi-input multi-output(MIMO) nonlinear systems affected by disturbances, which are generated by a known exosystem. An adaptive controller is designed based on the proposed observer and the backstepping approach to asymptotically track arbitrary reference signal and to guarantee the boundedness of all the signals in the closed loop system. Finally, the numerical simulation results illustrate the effectiveness of the proposed scheme.

  11. Curcumin blocks interleukin (IL)-2 signaling in T-lymphocytes by inhibiting IL-2 synthesis, CD25 expression, and IL-2 receptor signaling

    Energy Technology Data Exchange (ETDEWEB)

    Forward, Nicholas A.; Conrad, David M. [Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia (Canada); Power Coombs, Melanie R.; Doucette, Carolyn D. [Department of Pathology, Dalhousie University, Halifax, Nova Scotia (Canada); Furlong, Suzanne J. [Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia (Canada); Lin, Tong-Jun [Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia (Canada); Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia (Canada); Hoskin, David W., E-mail: d.w.hoskin@dal.ca [Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia (Canada); Department of Pathology, Dalhousie University, Halifax, Nova Scotia (Canada); Department of Surgery, Dalhousie University, Halifax, Nova Scotia (Canada)

    2011-04-22

    Highlights: {yields} Curcumin inhibits CD4{sup +} T-lymphocyte proliferation. {yields} Curcumin inhibits interleukin-2 (IL-2) synthesis and CD25 expression by CD4{sup +} T-lymphocytes. {yields} Curcumin interferes with IL-2 receptor signaling by inhibiting JAK3 and STAT5 phosphorylation. {yields} IL-2-dependent regulatory T-lymphocyte function and Foxp3 expression is downregulated by curcumin. -- Abstract: Curcumin (diferulomethane) is the principal curcuminoid in the spice tumeric and a potent inhibitor of activation-induced T-lymphocyte proliferation; however, the molecular basis of this immunosuppressive effect has not been well studied. Here we show that micromolar concentrations of curcumin inhibited DNA synthesis by mouse CD4{sup +} T-lymphocytes, as well as interleukin-2 (IL-2) and CD25 ({alpha} chain of the high affinity IL-2 receptor) expression in response to antibody-mediated cross-linking of CD3 and CD28. Curcumin acted downstream of protein kinase C activation and intracellular Ca{sup 2+} release to inhibit I{kappa}B phosphorylation, which is required for nuclear translocation of the transcription factor NF{kappa}B. In addition, IL-2-dependent DNA synthesis by mouse CTLL-2 cells, but not constitutive CD25 expression, was impaired in the presence of curcumin, which demonstrated an inhibitory effect on IL-2 receptor (IL-2R) signaling. IL-2-induced phosphorylation of STAT5A and JAK3, but not JAK1, was diminished in the presence of curcumin, indicating inhibition of critical proximal events in IL-2R signaling. In line with the inhibitory action of curcumin on IL-2R signaling, pretreatment of CD4{sup +}CD25{sup +} regulatory T-cells with curcumin downregulated suppressor function, as well as forkhead box p3 (Foxp3) expression. We conclude that curcumin inhibits IL-2 signaling by reducing available IL-2 and high affinity IL-2R, as well as interfering with IL-2R signaling.

  12. Curcumin blocks interleukin (IL)-2 signaling in T-lymphocytes by inhibiting IL-2 synthesis, CD25 expression, and IL-2 receptor signaling

    International Nuclear Information System (INIS)

    Highlights: → Curcumin inhibits CD4+ T-lymphocyte proliferation. → Curcumin inhibits interleukin-2 (IL-2) synthesis and CD25 expression by CD4+ T-lymphocytes. → Curcumin interferes with IL-2 receptor signaling by inhibiting JAK3 and STAT5 phosphorylation. → IL-2-dependent regulatory T-lymphocyte function and Foxp3 expression is downregulated by curcumin. -- Abstract: Curcumin (diferulomethane) is the principal curcuminoid in the spice tumeric and a potent inhibitor of activation-induced T-lymphocyte proliferation; however, the molecular basis of this immunosuppressive effect has not been well studied. Here we show that micromolar concentrations of curcumin inhibited DNA synthesis by mouse CD4+ T-lymphocytes, as well as interleukin-2 (IL-2) and CD25 (α chain of the high affinity IL-2 receptor) expression in response to antibody-mediated cross-linking of CD3 and CD28. Curcumin acted downstream of protein kinase C activation and intracellular Ca2+ release to inhibit IκB phosphorylation, which is required for nuclear translocation of the transcription factor NFκB. In addition, IL-2-dependent DNA synthesis by mouse CTLL-2 cells, but not constitutive CD25 expression, was impaired in the presence of curcumin, which demonstrated an inhibitory effect on IL-2 receptor (IL-2R) signaling. IL-2-induced phosphorylation of STAT5A and JAK3, but not JAK1, was diminished in the presence of curcumin, indicating inhibition of critical proximal events in IL-2R signaling. In line with the inhibitory action of curcumin on IL-2R signaling, pretreatment of CD4+CD25+ regulatory T-cells with curcumin downregulated suppressor function, as well as forkhead box p3 (Foxp3) expression. We conclude that curcumin inhibits IL-2 signaling by reducing available IL-2 and high affinity IL-2R, as well as interfering with IL-2R signaling.

  13. Exploitation of Ubiquitous Wi-Fi Devices as Building Blocks for Improvised Motion Detection Systems

    Directory of Open Access Journals (Sweden)

    Francesco Soldovieri

    2016-02-01

    Full Text Available This article deals with a feasibility study on the detection of human movements in indoor scenarios based on radio signal strength variations. The sensing principle exploits the fact that the human body interacts with wireless signals, introducing variations of the radiowave fields due to shadowing and multipath phenomena. As a result, human motion can be inferred from fluctuations of radiowave power collected by a receiving terminal. In this paper, we investigate the potentialities of widely available wireless communication devices in order to develop an improvised motion detection system (IMDS. Experimental tests are performed in an indoor environment by using a smartphone as a Wi-Fi access point and a laptop with dedicated software as a receiver. Simple detection strategies tailored for real-time operation are implemented to process the received signal strength measurements. The achieved results confirm the potentialities of the simple system here proposed to reliably detect human motion in operational conditions.

  14. Exploitation of Ubiquitous Wi-Fi Devices as Building Blocks for Improvised Motion Detection Systems.

    Science.gov (United States)

    Soldovieri, Francesco; Gennarelli, Gianluca

    2016-02-27

    This article deals with a feasibility study on the detection of human movements in indoor scenarios based on radio signal strength variations. The sensing principle exploits the fact that the human body interacts with wireless signals, introducing variations of the radiowave fields due to shadowing and multipath phenomena. As a result, human motion can be inferred from fluctuations of radiowave power collected by a receiving terminal. In this paper, we investigate the potentialities of widely available wireless communication devices in order to develop an improvised motion detection system (IMDS). Experimental tests are performed in an indoor environment by using a smartphone as a Wi-Fi access point and a laptop with dedicated software as a receiver. Simple detection strategies tailored for real-time operation are implemented to process the received signal strength measurements. The achieved results confirm the potentialities of the simple system here proposed to reliably detect human motion in operational conditions.

  15. Digital signal processing in power system protection and control

    CERN Document Server

    Rebizant, Waldemar; Wiszniewski, Andrzej

    2011-01-01

    Digital Signal Processing in Power System Protection and Control bridges the gap between the theory of protection and control and the practical applications of protection equipment. Understanding how protection functions is crucial not only for equipment developers and manufacturers, but also for their users who need to install, set and operate the protection devices in an appropriate manner. After introductory chapters related to protection technology and functions, Digital Signal Processing in Power System Protection and Control presents the digital algorithms for signal filtering, followed

  16. Double CAN communicating building block based on embedded system μC/OS-Ⅱ

    Institute of Scientific and Technical Information of China (English)

    Mo,Chuanmeng; Feng,Xiaoyu

    2004-01-01

    On the basis of transplanting successfully a suit of RTOS μC/OS-Ⅱ to MB90F543 MCU, double CAN communicating program module have been embedded into μC/OS-Ⅱ as a building block. Double CAN redundant communication have been realized among several hardware nodes based on μC/OS-Ⅱ. The design mechanism, hardware and software of double CAN communication were described in detail. The paper analyze the differences of CAN communication based on μC/OS-Ⅱ and traditional foreground/background system.Key Word:RTOS; μC/OS-Ⅱ;CAN bus;MB90F543 MCU;redundancy

  17. Emergency vehicle traffic signal preemption system

    Science.gov (United States)

    Bachelder, Aaron D. (Inventor); Foster, Conrad F. (Inventor)

    2011-01-01

    An emergency vehicle traffic light preemption system for preemption of traffic lights at an intersection to allow safe passage of emergency vehicles. The system includes a real-time status monitor of an intersection which is relayed to a control module for transmission to emergency vehicles as well as to a central dispatch office. The system also provides for audio warnings at an intersection to protect pedestrians who may not be in a position to see visual warnings or for various reasons cannot hear the approach of emergency vehicles. A transponder mounted on an emergency vehicle provides autonomous control so the vehicle operator can attend to getting to an emergency and not be concerned with the operation of the system. Activation of a priority-code (i.e. Code-3) situation provides communications with each intersection being approached by an emergency vehicle and indicates whether the intersection is preempted or if there is any conflict with other approaching emergency vehicles. On-board diagnostics handle various information including heading, speed, and acceleration sent to a control module which is transmitted to an intersection and which also simultaneously receives information regarding the status of an intersection. Real-time communications and operations software allow central and remote monitoring, logging, and command of intersections and vehicles.

  18. Early warning signals of tipping points in periodically forced systems

    Science.gov (United States)

    Williamson, Mark S.; Bathiany, Sebastian; Lenton, Timothy M.

    2016-04-01

    The prospect of finding generic early warning signals of an approaching tipping point in a complex system has generated much interest recently. Existing methods are predicated on a separation of timescales between the system studied and its forcing. However, many systems, including several candidate tipping elements in the climate system, are forced periodically at a timescale comparable to their internal dynamics. Here we use alternative early warning signals of tipping points due to local bifurcations in systems subjected to periodic forcing whose timescale is similar to the period of the forcing. These systems are not in, or close to, a fixed point. Instead their steady state is described by a periodic attractor. For these systems, phase lag and amplification of the system response can provide early warning signals, based on a linear dynamics approximation. Furthermore, the Fourier spectrum of the system's time series reveals harmonics of the forcing period in the system response whose amplitude is related to how nonlinear the system's response is becoming with nonlinear effects becoming more prominent closer to a bifurcation. We apply these indicators as well as a return map analysis to a simple conceptual system and satellite observations of Arctic sea ice area, the latter conjectured to have a bifurcation type tipping point. We find no detectable signal of the Arctic sea ice approaching a local bifurcation.

  19. 小干扰RNA阻断Olf-1/EBF相关锌指蛋白信号通路对狼疮抗核抗体产生的影响%Effect of OAZ signaling blocking through small interfering RNA on the production of anti-nuclear antibody in systemic lupus erythematosus

    Institute of Scientific and Technical Information of China (English)

    李荣良; 黄静; 周涛; 孙凌云; 冯学兵

    2010-01-01

    Objective To explore the role of OAZ gene in the pathogenesis of systemic lupus erythe-matosus (SLE) by using RNA interfering technique. Methods Peripheral blood mononuclear cells (PBMC) from SLE patients were collected. Each sample was equally divided into four groups for cell culture in 96 well plates. Specific siRNA for OAZ and GAPDH were concordantly added to the experimental group and the positive control group, while nonspecific siRNA was added to the negative control group and only culture medium was added to the Mock control group. Cells and supernatants were harvested after culturing for 72 hours, then RNA was extracted and reverse transcripted to cDNA. OAZ, Id1, Id2, Id3, Id4 mRNA expression levels were analyzed by using real-time PCR. Levels of IFN-γ, IL-4, IL-10, IL-12, IL-21, CCL2, ANA in the supernatant were tested by ELISA. Relationships between the expression levels of OAZ mRNA with levels of cytokines and ANA were analyzed. Results OAZ, Id1, Id2, Id3 gene mRNA expression levels (△Ct: 12.5±1.4, 8.9±1.5, 4.3±0.8, 8.04±1.1) in the experimental group were significantly decreased comparing to those in the negative control group (△Ct: 10.2±1.1, 6.5±1.2, 2.4±1.3, 6.2±1.2 respectively, P<0.05). Levels of IFN-γ, IL-10, IL-12, IL-21 and ANA in the experimental group were significantly lower than those in the negative control group (P< 0.05), but level of CCL2 was higher than the negative control group (P<0.05). Difference of OAZ mRNA expression levels (△△Ct) between the experimental group and the negative control group was negatively correlated with changes of ANA, IL-21 levels, but positively correlated with changes of Th1/Th2, CCL2. Conclusion OAZ siRNA can effectively reduce the expression of genes involved in the OAZ signaling pathway in SLE. OAZ may lead to abnormal production of ANA via regulating Id genes and cytokines.%目的 运用RNA干扰(RNAi)技术研究Olf-1/EBF相关锌指蛋白(OAZ)对其信号通路相关基因的干预作

  20. Massive MIMO Systems: Signal Processing Challenges and Research Trends

    OpenAIRE

    de Lamare, R.C.

    2013-01-01

    This article presents a tutorial on multiuser multiple-antenna wireless systems with a very large number of antennas, known as massive multi-input multi-output (MIMO) systems. Signal processing challenges and future trends in the area of massive MIMO systems are presented and key application scenarios are detailed. A linear algebra approach is considered for the description of the system and data models of massive MIMO architectures. The operational requirements of massive MIMO systems are di...

  1. An innovative nonintrusive driver assistance system for vital signal monitoring.

    Science.gov (United States)

    Sun, Ye; Yu, Xiong Bill

    2014-11-01

    This paper describes an in-vehicle nonintrusive biopotential measurement system for driver health monitoring and fatigue detection. Previous research has found that the physiological signals including eye features, electrocardiography (ECG), electroencephalography (EEG) and their secondary parameters such as heart rate and HR variability are good indicators of health state as well as driver fatigue. A conventional biopotential measurement system requires the electrodes to be in contact with human body. This not only interferes with the driver operation, but also is not feasible for long-term monitoring purpose. The driver assistance system in this paper can remotely detect the biopotential signals with no physical contact with human skin. With delicate sensor and electronic design, ECG, EEG, and eye blinking can be measured. Experiments were conducted on a high fidelity driving simulator to validate the system performance. The system was found to be able to detect the ECG/EEG signals through cloth or hair with no contact with skin. Eye blinking activities can also be detected at a distance of 10 cm. Digital signal processing algorithms were developed to decimate the signal noise and extract the physiological features. The extracted features from the vital signals were further analyzed to assess the potential criterion for alertness and drowsiness determination. PMID:25375690

  2. Relationship between blocking temperature and strength of interparticle interaction in magnetic nanoparticle systems

    Science.gov (United States)

    Seehra, M. S.; Pisane, K. L.

    2016-06-01

    In magnetic nanoparticle systems, the variation of the blocking temperature TB with the measuring frequency fm is often used to determine the strength of the interparticle interactions (IPI) through a parameter Φ or the Vogel-Fulcher temperature To. Presence of IPI is inferred if To > 0 and Φ = ∆TB/[ TB ∆ log10fm ] < 0.13 where Δ signifies changes in TB and fm. Here it is shown that these two parameters are related by the Eq. Φ = Φo [ 1 - (To/TB(1)) ] where Φo ≈ 0.11-0.15 is a constant of the system depending on the magnitudes of measuring frequency and the attempt frequency fo of the Néel relaxation. Using data on a variety of nanoparticle systems, experimental verification of this relationship is also presented.

  3. The application of information theory to biochemical signaling systems.

    Science.gov (United States)

    Rhee, Alex; Cheong, Raymond; Levchenko, Andre

    2012-08-01

    Cell signaling can be thought of fundamentally as an information transmission problem in which chemical messengers relay information about the external environment to the decision centers within a cell. Due to the biochemical nature of cellular signal transduction networks, molecular noise will inevitably limit the fidelity of any messages received and processed by a cell's signal transduction networks, leaving it with an imperfect impression of its environment. Fortunately, Shannon's information theory provides a mathematical framework independent of network complexity that can quantify the amount of information that can be transmitted despite biochemical noise. In particular, the channel capacity can be used to measure the maximum number of stimuli a cell can distinguish based upon the noisy responses of its signaling systems. Here, we provide a primer for quantitative biologists that covers fundamental concepts of information theory, highlights several key considerations when experimentally measuring channel capacity, and describes successful examples of the application of information theoretic analysis to biological signaling.

  4. A Bioassay System Using Bioelectric Signals from Small Fish

    Science.gov (United States)

    Terawaki, Mitsuru; Soh, Zu; Hirano, Akira; Tsuji, Toshio

    Although the quality of tap water is generally examined using chemical assay, this method cannot be used for examination in real time. Against such a background, the technique of fish bioassay has attracted attention as an approach that enables constant monitoring of aquatic contamination. The respiratory rhythms of fish are considered an efficient indicator for the ongoing assessment of water quality, since they are sensitive to chemicals and can be indirectly measured from bioelectric signals generated by breathing. In order to judge aquatic contamination accurately, it is necessary to measure bioelectric signals from fish swimming freely as well as to stably discriminate measured signals, which vary between individuals. However, no bioassay system meeting the above requirements has yet been established. This paper proposes a bioassay system using bioelectric signals generated from small fish in free-swimming conditions. The system records signals using multiple electrodes to cover the extensive measurement range required in a free-swimming environment, and automatically discriminates changes in water quality from signal frequency components. This discrimination is achieved through an ensemble classification method using probability neural networks to solve the problem of differences between individual fish. The paper also reports on the results of related validation experiments, which showed that the proposed system was able to stably discriminate between water conditions before and after bleach exposure.

  5. Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells

    OpenAIRE

    Pan, Jing-Xuan; Ding, Ke; Wang, Cheng-Yan

    2012-01-01

    Niclosamide, an oral antihelminthic drug, has been used to treat tapeworm infection for about 50 years. Niclosamide is also used as a molluscicide for water treatment in schistosomiasis control programs. Recently, several groups have independently discovered that niclosamide is also active against cancer cells, but its precise mechanism of antitumor action is not fully understood. Evidence supports that niclosamide targets multiple signaling pathways (NF-κB, Wnt/β-catenin, Notch, ROS, mTORC1,...

  6. Application of signal detection theory to assess optoacoustic imaging systems

    Science.gov (United States)

    Lou, Yang; Oraevsky, Alexander; Anastasio, Mark A.

    2016-03-01

    The hybrid nature of optoacoustic tomography (OAT) brings together the advantages of both optical imaging and ultrasound imaging, making it a promising tool for breast cancer imaging. It is advocated in the modern imaging science literature to utilize objective, or task-based, measures of system performance to guide the optimization of hardware design and image reconstruction algorithms. In this work, we investigate this approach to assess the performance of OAT breast imaging systems. In particular, we apply principles from signal detection theory to compute the detectability of a simulated tumor at different depths within a breast, for two different system designs. The signal-to-noise ratio of the test statistic computed by a numerical observer is employed as the task-specific summary measure of system performance. A numerical breast model is employed that contains both slowly varying background and vessel structures as the background model, and superimpose a deterministic signal to emulate a tumor. This study demonstrates how signal detection performance of a numerical observer will vary as a function of signal depth and imaging system characteristics. The described methodology can be employed readily to systematically optimize other OAT imaging systems for tumor detection tasks.

  7. Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.

    Science.gov (United States)

    Tokarski, John S; Zupa-Fernandez, Adriana; Tredup, Jeffrey A; Pike, Kristen; Chang, ChiehYing; Xie, Dianlin; Cheng, Lihong; Pedicord, Donna; Muckelbauer, Jodi; Johnson, Stephen R; Wu, Sophie; Edavettal, Suzanne C; Hong, Yang; Witmer, Mark R; Elkin, Lisa L; Blat, Yuval; Pitts, William J; Weinstein, David S; Burke, James R

    2015-04-24

    Inhibition of signal transduction downstream of the IL-23 receptor represents an intriguing approach to the treatment of autoimmunity. Using a chemogenomics approach marrying kinome-wide inhibitory profiles of a compound library with the cellular activity against an IL-23-stimulated transcriptional response in T lymphocytes, a class of inhibitors was identified that bind to and stabilize the pseudokinase domain of the Janus kinase tyrosine kinase 2 (Tyk2), resulting in blockade of receptor-mediated activation of the adjacent catalytic domain. These Tyk2 pseudokinase domain stabilizers were also shown to inhibit Tyk2-dependent signaling through the Type I interferon receptor but not Tyk2-independent signaling and transcriptional cellular assays, including stimulation through the receptors for IL-2 (JAK1- and JAK3-dependent) and thrombopoietin (JAK2-dependent), demonstrating the high functional selectivity of this approach. A crystal structure of the pseudokinase domain liganded with a representative example showed the compound bound to a site analogous to the ATP-binding site in catalytic kinases with features consistent with high ligand selectivity. The results support a model where the pseudokinase domain regulates activation of the catalytic domain by forming receptor-regulated inhibitory interactions. Tyk2 pseudokinase stabilizers, therefore, represent a novel approach to the design of potent and selective agents for the treatment of autoimmunity. PMID:25762719

  8. Embryonic tongue morphogenesis in an organ culture model of mouse mandibular arches: blocking Sonic hedgehog signaling leads to microglossia.

    Science.gov (United States)

    Torii, Daisuke; Soeno, Yuuichi; Fujita, Kazuya; Sato, Kaori; Aoba, Takaaki; Taya, Yuji

    2016-01-01

    Mouse tongue development is initiated with the formation of lateral lingual swellings just before fusion between the mediodorsal surfaces of the mandibular arches at around embryonic day 11.0. Here, we investigated the role of Sonic hedgehog (Shh) signaling in embryonic mouse tongue morphogenesis. For this, we used an organ culture model of the mandibular arches from mouse embryos at embryonic day 10.5. When the Shh signaling inhibitor jervine was added to the culture medium for 24-96 h, the formation of lateral lingual swellings and subsequent epithelial invagination into the mesenchyme were impaired markedly, leading to a hypoplastic tongue with an incomplete oral sulcus. Notably, jervine treatment reduced the proliferation of non-myogenic mesenchymal cells at the onset of forming the lateral lingual swellings, whereas it did not affect the proliferation and differentiation of a myogenic cell lineage, which created a cell community at the central circumferential region of the lateral lingual swellings as seen in vivo and in control cultures lacking the inhibitor. Thus, epithelium-derived Shh signaling stimulates the proliferation of non-myogenic mesenchymal cells essential for forming lateral lingual swellings and contributes to epithelial invagination into the mesenchyme during early tongue development.

  9. Blind and semi-blind ML detection for space-time block-coded OFDM wireless systems

    KAUST Repository

    Zaib, Alam

    2014-01-01

    This paper investigates the joint maximum likelihood (ML) data detection and channel estimation problem for Alamouti space-time block-coded (STBC) orthogonal frequency-division multiplexing (OFDM) wireless systems. The joint ML estimation and data detection is generally considered a hard combinatorial optimization problem. We propose an efficient low-complexity algorithm based on branch-estimate-bound strategy that renders exact joint ML solution. However, the computational complexity of blind algorithm becomes critical at low signal-to-noise ratio (SNR) as the number of OFDM carriers and constellation size are increased especially in multiple-antenna systems. To overcome this problem, a semi-blind algorithm based on a new framework for reducing the complexity is proposed by relying on subcarrier reordering and decoding the carriers with different levels of confidence using a suitable reliability criterion. In addition, it is shown that by utilizing the inherent structure of Alamouti coding, the estimation performance improvement or the complexity reduction can be achieved. The proposed algorithms can reliably track the wireless Rayleigh fading channel without requiring any channel statistics. Simulation results presented against the perfect coherent detection demonstrate the effectiveness of blind and semi-blind algorithms over frequency-selective channels with different fading characteristics.

  10. Outage performance of cognitive radio systems with Improper Gaussian signaling

    KAUST Repository

    Amin, Osama

    2015-06-14

    Improper Gaussian signaling has proved its ability to improve the achievable rate of the systems that suffer from interference compared with proper Gaussian signaling. In this paper, we first study impact of improper Gaussian signaling on the performance of the cognitive radio system by analyzing the outage probability of both the primary user (PU) and the secondary user (SU). We derive exact expression of the SU outage probability and upper and lower bounds for the PU outage probability. Then, we design the SU signal by adjusting its transmitted power and the circularity coefficient to minimize the SU outage probability while maintaining a certain PU quality-of-service. Finally, we evaluate the proposed bounds and adaptive algorithms by numerical results.

  11. Signal structure of the Chinese Area Positioning System

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Proper signal structure is very important in the navigation, positioning, and time services of a satellite navigation system. In this paper, the carrier wave characteristics, ranging code functions, BOC modulation, navigation data rate, the error-correcting methods, and signal channel resource allocation are discussed in terms of the technical characteristics of the transforming satellite navigation system and the resources of communication satellites. The results show that dual-frequency of C band in the Chinese Area Positioning System (CAPS), compound ranging code, a combination of the coarse code and precise code, BOC modulation, separate-channel transmission of different users are compatible with the satellite navigation system at present. The experiments show that the current signal structure can meet the demand of CAPS.

  12. Performance of Turbo Interference Cancellation Receivers in Space-Time Block Coded DS-CDMA Systems

    Directory of Open Access Journals (Sweden)

    Emmanuel Oluremi Bejide

    2008-07-01

    Full Text Available We investigate the performance of turbo interference cancellation receivers in the space time block coded (STBC direct-sequence code division multiple access (DS-CDMA system. Depending on the concatenation scheme used, we divide these receivers into the partitioned approach (PA and the iterative approach (IA receivers. The performance of both the PA and IA receivers is evaluated in Rayleigh fading channels for the uplink scenario. Numerical results show that the MMSE front-end turbo space-time iterative approach receiver (IA effectively combats the mixture of MAI and intersymbol interference (ISI. To further investigate the possible achievable data rates in the turbo interference cancellation receivers, we introduce the puncturing of the turbo code through the use of rate compatible punctured turbo codes (RCPTCs. Simulation results suggest that combining interference cancellation, turbo decoding, STBC, and RCPTC can significantly improve the achievable data rates for a synchronous DS-CDMA system for the uplink in Rayleigh flat fading channels.

  13. Application of Block Copolymer in Three-Liquid-Phase Extraction System

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    A novel three-liquid-phase extraction system (TES) composed of butyl acetate, block copolymer polyethylene oxide-polypropylene oxide-polyethylene oxide and ammonium sulphate aqueous solution [(NH4)2SO4] as top, middle, and bottom phase, respectively, has been developed. The copolymer recycling and partitioning behavior of penicillin V has been studied in this system. Results show that the copolymer could be purified and recycled and penicillin V of the filtrated ferment broth could be partitioned unevenly among the phases and purified in the top phase of this TES. About 90 wt.% of penicillin V could be distributed into the top phase around pH 2.5 and only less than 0.1 wt.% left in the bottom phase.

  14. Signals and systems for bioengineers a Matlab-based introduction

    CERN Document Server

    Semmlow, John

    2011-01-01

    This book guides the reader through the electrical engineering principles that can be applied to biological systems and are therefore important to biomedical studies. The basic engineering concepts that underlie biomedical systems, medical devices, biocontrol, and biosignal analysis are explained in detail.This textbook is perfect for the one-semester bioengineering course usually offered in conjunction with a laboratory on signals and measurements which presents the fundamentals of systems and signal analysis. The target course occupies a pivotal position in the bioengineering curricu

  15. Input–output robustness in simple bacterial signaling systems

    OpenAIRE

    Shinar, Guy; Milo, Ron; Martínez, María Rodríguez; Alon, Uri

    2007-01-01

    Biological signaling systems produce an output, such as the level of a phosphorylated protein, in response to defined input signals. The output level as a function of the input level is called the system's input–output relation. One may ask whether this input–output relation is sensitive to changes in the concentrations of the system's components, such as proteins and ATP. Because component concentrations often vary from cell to cell, it might be expected that the input–output relation will l...

  16. Digital Signal Processing for Optical Coherent Communication Systems

    DEFF Research Database (Denmark)

    Zhang, Xu

    In this thesis, digital signal processing (DSP) algorithms are studied to compensate for physical layer impairments in optical fiber coherent communication systems. The physical layer impairments investigated in this thesis include optical fiber chromatic dispersion, polarization demultiplexing...... less hardware requirements than a conventional serial chromatic dispersion compensation algorithm. In conclusion, the digital signal processing algorithms presented in this thesis have shown to improve the performance of digital assisted coherent receivers for the next generation of optical fiber...

  17. Stochastic resonance in two-frequency signal systems

    Science.gov (United States)

    Song, Hui; Huang, Shengming; Liu, Xuemei

    2016-04-01

    Signal-to-noise ratio (SNR) in two-frequency signal systems is investigated in the presence of the correlated multiplicative and white additive noises. From the Wiener-Khinchin theorem, the exact expression of the SNR is obtained. It is found that stochastic resonance (SR) appears when two frequencies are almost the same, while SR gradually disappears when the frequency difference increases. We also found that there exists an optimized value of the frequency at which SNR takes its maximal value.

  18. A block iterative LU solver for weakly coupled linear systems. [in fluid dynamics equations

    Science.gov (United States)

    Cooke, C. H.

    1977-01-01

    A hybrid technique, called the block iterative LU solver, is proposed for solving the linear equations resulting from a finite element numerical analysis of certain fluid dynamics problems where the equations are weakly coupled between distinct sets of variables. Either the block Jacobi iterative method or the block Gauss-Seidel iterative solver is combined with LU decomposition.

  19. MiR-122 directly inhibits human papillomavirus E6 gene and enhances interferon signaling through blocking suppressor of cytokine signaling 1 in SiHa cells.

    Directory of Open Access Journals (Sweden)

    Junming He

    Full Text Available Human Papillomavirus (HPV 16 infection is considered as one of the significant causes of human cervical cancer. The expression of the viral oncogenes like E6 and E7 play an important role in the development of the cancer. MiR-122 has been reported to exhibit a strong relationship with hepatitis viruses and take part in several tumor development, while the effects of miR-122 on HPV infection and the HPV viral oncogenes expression still remain unexplored. In this study, using RNAhybrid software, the potential binding sites between miR-122 and HPV16 E6 and E7 mRNAs were identified. Over and loss of miR-122 function showed that miR-122 could directly bind with HPV16 E6 mRNA and significantly inhibit its expression in SiHa cells, which was further confirmed by constructing the miR-122-E6-mu to eliminate the miR-122 binding effects with E6. The increase of the expression of type I interferon (IFN and its classical effective molecules and the phosphorylation of signal transducers and activators of transcription (STAT1 protein indicated that miR-122 might enhance type I interferon in cervical carcinoma cells, which explained the significant reduction of HPV16 E7 and E6*I mRNA expression. This might be due to the binding between miR-122 and suppressor of cytokine signaling 1 (SOCS1 mRNA, which is the suppressor of interferon signaling pathway. Moreover, it was identified that the miR-122 binding position was nt359-nt375 in SOCS1 mRNA. Taken together, this study indicated that HPV16 could be effectively inhibited by miR-122 through both direct binding with E6 mRNA and promoting SOCS1-dependent IFN signaling pathway. Thus, miR-122 may serve as a new therapeutic option for inhibiting HPV infection.

  20. Digital Signal Processor System for AC Power Drivers

    Directory of Open Access Journals (Sweden)

    Ovidiu Neamtu

    2009-10-01

    Full Text Available DSP (Digital Signal Processor is the bestsolution for motor control systems to make possible thedevelopment of advanced motor drive systems. The motorcontrol processor calculates the required motor windingvoltage magnitude and frequency to operate the motor atthe desired speed. A PWM (Pulse Width Modulationcircuit controls the on and off duty cycle of the powerinverter switches to vary the magnitude of the motorvoltages.

  1. Complete Congenital Heart Block in a Newborn Associated with Maternal Systemic Lupus Erythematosus: A Case Report

    Directory of Open Access Journals (Sweden)

    Mahmoud A. Kiblawi

    2013-12-01

    Full Text Available Background: Complete Congenital Heart Block (CCHB is a rare disease of the newborn that carries significant morbidity and mortality. CCHB can be diagnosed early or late in life. In newborns, it is usually associated with maternal autoantibodies or a congenital cardiac structural abnormality. The most common presentation of CCHB is bradycardia that can be diagnosed by an electrocardiogram. Results: This is a case report of a male infant born to a mother with an autoimmune disease, Systemic Lupus Erythematosus (SLE, who was found to have third degree heart block at birth. Conclusion: Early diagnosis and prompt management of the case is important for a better prognosis and prevention of associated complications. Neonates with CCHB should be managed at a tertiary care center and the only definite treatment is insertion of a pacemaker. Moreover, prenatal diagnosis and specific obstetric counseling of pregnant women with SLE along with careful monitoring with serial ultrasonography and echocardiography are of paramount importance in prevention of the disease in subsequent offspring.

  2. Berberine Protects Human Umbilical Vein Endothelial Cells against LPS-Induced Apoptosis by Blocking JNK-Mediated Signaling

    Science.gov (United States)

    Guo, Junping; Wang, Lijun; Wang, Linyao; Qian, Senmi; Fang, Jie

    2016-01-01

    Endothelial dysfunction is a critical factor during the initiation of atherosclerosis. Berberine has a beneficial effect on endothelial function; however, the underlying mechanisms remain unclear. In this study, we investigated the effects of berberine on lipopolysaccharide- (LPS-) induced apoptosis in human umbilical vein endothelial cells (HUVECs) and the molecular mechanisms mediating the effect. The effects of berberine on LPS-induced cell apoptosis and viability were measured with 5-ethynyl-2′-deoxyuridine staining, flow cytometry, and Cell Counting Kit-8 assays. The expression and/or activation of proapoptotic and antiapoptotic proteins or signaling pathways, including caspase-3, poly(ADP-ribose) polymerase, myeloid cell leukemia-1 (MCL-1), p38 mitogen-activated protein kinase, C-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinase, were determined with western blotting. The malondialdehyde levels, superoxide dismutase (SOD) activity, and production of proinflammatory cytokines were measured with enzyme-linked immunosorbent assays. The results demonstrated that berberine pretreatment protected HUVECs from LPS-induced apoptosis, attenuated LPS-induced injury, inhibited LPS-induced JNK phosphorylation, increased MCL-1 expression and SOD activity, and decreased proinflammatory cytokine production. The effects of berberine on LPS-treated HUVECs were prevented by SP600125, a JNK-specific inhibitor. Thus, berberine might be a potential candidate in the treatment of endothelial cell injury-related vascular diseases. PMID:27478481

  3. Berberine Protects Human Umbilical Vein Endothelial Cells against LPS-Induced Apoptosis by Blocking JNK-Mediated Signaling.

    Science.gov (United States)

    Guo, Junping; Wang, Lijun; Wang, Linyao; Qian, Senmi; Zhang, Dayong; Fang, Jie; Pan, Jianping

    2016-01-01

    Endothelial dysfunction is a critical factor during the initiation of atherosclerosis. Berberine has a beneficial effect on endothelial function; however, the underlying mechanisms remain unclear. In this study, we investigated the effects of berberine on lipopolysaccharide- (LPS-) induced apoptosis in human umbilical vein endothelial cells (HUVECs) and the molecular mechanisms mediating the effect. The effects of berberine on LPS-induced cell apoptosis and viability were measured with 5-ethynyl-2'-deoxyuridine staining, flow cytometry, and Cell Counting Kit-8 assays. The expression and/or activation of proapoptotic and antiapoptotic proteins or signaling pathways, including caspase-3, poly(ADP-ribose) polymerase, myeloid cell leukemia-1 (MCL-1), p38 mitogen-activated protein kinase, C-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinase, were determined with western blotting. The malondialdehyde levels, superoxide dismutase (SOD) activity, and production of proinflammatory cytokines were measured with enzyme-linked immunosorbent assays. The results demonstrated that berberine pretreatment protected HUVECs from LPS-induced apoptosis, attenuated LPS-induced injury, inhibited LPS-induced JNK phosphorylation, increased MCL-1 expression and SOD activity, and decreased proinflammatory cytokine production. The effects of berberine on LPS-treated HUVECs were prevented by SP600125, a JNK-specific inhibitor. Thus, berberine might be a potential candidate in the treatment of endothelial cell injury-related vascular diseases. PMID:27478481

  4. The Ballistocardiogram Signal Monitoring System Based on the GSM Network

    Institute of Scientific and Technical Information of China (English)

    WANG Chun-wu; WANG Xu; LONG Zhe; ZHANG Ke-xin; YANG Dan

    2015-01-01

    Ballistocardiogram signal monitoring system based on GSM network was put forward in this paper. The system included a BCG signal acquisition module, a data processing module, a display module and a GSM module. The STM32F103VB microprocessor was used as the controlling core of the signal acquisition module. BCG signal acquisition, amplification, filtering and A/D conversion were completed by the resistance strain sensor and high precision A/D conversion chip of TM7708; VB6.0 software was used to realize the BCG signal analysis and processing;the SD card and LCD completed data storage and waveform display; the BCG data remote transmission and alarm function were realized through the GSM module. The system cannot only real-time monitor the changes of heart rate of patients by non-contact means, and can process data automatically, timely detection of arrhythmia and automatic alarm. The system is particularly suitable for heart disease patients receiving long-term home care;therefore, it has a broad application prospect.

  5. Parallel Signal Processing and System Simulation using aCe

    Science.gov (United States)

    Dorband, John E.; Aburdene, Maurice F.

    2003-01-01

    Recently, networked and cluster computation have become very popular for both signal processing and system simulation. A new language is ideally suited for parallel signal processing applications and system simulation since it allows the programmer to explicitly express the computations that can be performed concurrently. In addition, the new C based parallel language (ace C) for architecture-adaptive programming allows programmers to implement algorithms and system simulation applications on parallel architectures by providing them with the assurance that future parallel architectures will be able to run their applications with a minimum of modification. In this paper, we will focus on some fundamental features of ace C and present a signal processing application (FFT).

  6. [Study on neurofeedback system based on electroencephalogram signals].

    Science.gov (United States)

    Pu, Xianjie; Liu, Tiejun; Wu, Qiang; Zhang, Rui; Xu, Peng; Li, Ke; Xia, Yang; Yao, Dezhong

    2014-08-01

    Neurofeedback, as an alternative treatment method of behavioral medicine, is a technique which translates the electroencephalogram (EEG) signals to styles as sounds or animation to help people understand their own physical status and learn to enhance or suppress certain EEG signals to regulate their own brain functions after several repeated trainings. This paper develops a neurofeedback system on the foundation of brain-computer interface technique. The EEG features are extracted through real-time signal process and then translated to feedback information. Two feedback screens are designed for relaxation training and attention training individually. The veracity and feasibility of the neurofeedback system are validated through system simulation and preliminary experiment. Key words: neurofeedback; electroencephalogram; feature extraction; brain-computer interface PMID:25508440

  7. Chaotic oscillator detection system about weak signals in spot welding

    Institute of Scientific and Technical Information of China (English)

    Kai-lei SONG; Zhen LUO; Feng YE; Xin-xin TANG; Shu-xian YUAN

    2009-01-01

    Spot welding is an efficient and shortcut processing method used in plate, and its quality detection is very important. However, there are many factors affecting the spot welding quality. Because of the low precision of traditional detection methods, spot welding has seldom been used in the aerospace industry which requires high welding quality. In this article, we give a new weak signal detection model based on chaotic oscillators. Using Melnikov methods and Lyapunov exponent, we can determine the critical values when the system enters in and out of chaos. Through lots of numerical simulations, it can be found that the lowest value of the weak sinusoidal signal the system can detect reach 10-11, and its signal-to-noise ratio (SNR) is = 126 dB. Compared with other detection methods, chaos oscillator detection system not only has a lower threshold value, but also is easy to implement in practice. This model thus has good application prospects.

  8. A four-channel microelectronic system for neural signal regeneration

    Energy Technology Data Exchange (ETDEWEB)

    Xie Shushan; Wang Zhigong; Li Wenyuan [Institute of RF- and OE-ICs, Southeast University, Nanjing 210096 (China); Lue Xiaoying; Pan Haixian, E-mail: zgwang@seu.edu.c [State Key Laboratory of Bio-Electronics, Southeast University, Nanjing 210096 (China)

    2009-12-15

    This paper presents a microelectronic system which is capable of making a signal record and functional electric stimulation of an injured spinal cord. As a requirement of implantable engineering for the regeneration microelectronic system, the system is of low noise, low power, small size and high performance. A front-end circuit and two high performance OPAs (operational amplifiers) have been designed for the system with different functions, and the two OPAs are a low-noise low-power two-stage OPA and a constant-g{sub m} RTR input and output OPA. The system has been realized in CSMC 0.5-{mu}m CMOS technology. The test results show that the system satisfies the demands of neuron signal regeneration. (semiconductor integrated circuits)

  9. A four-channel microelectronic system for neural signal regeneration

    Institute of Scientific and Technical Information of China (English)

    Xie Shushan; Wang Zhigong; Lü Xiaoying; Li Wenyuan; Pan Haixian

    2009-01-01

    This paper presents a microelectronic system which is capable of making a signal record and functional electric stimulation of an injured spinal cord. As a requirement of implantable engineering for the regeneration microelectronic system, the system is of low noise, low power, small size and high performance. A front-end circuit and two high performance OPAs (operational amplifiers) have been designed for the system with different functions,and the two OPAs are a low-noise low-power two-stage OPA and a constant-g_m RTR input and output OPA. The system has been realized in CSMC 0.5-μm CMOS technology. The test results show that the system satisfies the demands of neuron signal regeneration.

  10. A Multiagent System for Integrated Detection of Pharmacovigilance Signals.

    Science.gov (United States)

    Koutkias, Vassilis; Jaulent, Marie-Christine

    2016-02-01

    Pharmacovigilance is the scientific discipline that copes with the continuous assessment of the safety profile of marketed drugs. This assessment relies on diverse data sources, which are routinely analysed to identify the so-called "signals", i.e. potential associations between drugs and adverse effects, that are unknown or incompletely documented. Various computational methods have been proposed to support domain experts in signal detection. However, recent comparative studies illustrated that current methods exhibit high false-positive rates, significantly variable performance across different datasets used for analysis and events of interest, but also complementarity in their outcomes. In this regard, in order to reinforce accurate and timely signal detection, we elaborated through an agent-based approach towards systematic, joint exploitation of multiple heterogeneous signal detection methods, data sources and other drug-related resources under a common, integrated framework. The approach relies on a multiagent system operating based on a collaborative agent interaction protocol, aiming to implement a comprehensive workflow that comprises of method selection and execution, as well as outcomes' aggregation, filtering, ranking and annotation. This paper presents the design of the proposed multiagent system, discusses implementation issues and demonstrates the applicability of the proposed solution in an example signal detection scenario. This work constitutes a step towards large-scale, integrated and knowledge-intensive computational signal detection. PMID:26590975

  11. An efficient user scheduling scheme for downlink Multiuser MIMO-OFDM systems with Block Diagonalization

    Directory of Open Access Journals (Sweden)

    Mounir Esslaoui

    2013-06-01

    Full Text Available The combination of multiuser multiple-input multiple-output (MU-MIMO technology with orthogonal frequency division multiplexing (OFDM is an attractive solution for next generation of wireless local area networks (WLANs, currently standardized within IEEE 802.11ac, and the fourth-generation (4G mobile cellular wireless systems to achieve a very high system throughput while satisfying quality of service (QoS constraints. In particular, Block Diagonalization (BD scheme is a low-complexity precoding technique for MU-MIMO downlink channels, which completely pre-cancels the multiuser interference. The major issue of the BD scheme is that the number of users that can be simultaneously supported is limited by the ratio of the number of base station transmit antennas to the number of user receive antennas. When the number of users is large, a subset of users must be selected, and selection algorithms should be designed to maximize the total system throughput. In this paper, the BD technique is extended to MU-MIMO-OFDM systems and a low complexity user scheduling algorithm is proposed to find the optimal subset of users that should transmit simultaneously, in light of the instantaneous channel state information (CSI, such that the total system sum-rate capacity is maximized. Simulation results show that the proposed scheduling algorithm achieves a good trade-off between sum-rate capacity performance and computational complexity.

  12. Space-Frequency Block Code with Matched Rotation for MIMO-OFDM System with Limited Feedback

    Directory of Open Access Journals (Sweden)

    Thushara D. Abhayapala

    2009-01-01

    Full Text Available This paper presents a novel matched rotation precoding (MRP scheme to design a rate one space-frequency block code (SFBC and a multirate SFBC for MIMO-OFDM systems with limited feedback. The proposed rate one MRP and multirate MRP can always achieve full transmit diversity and optimal system performance for arbitrary number of antennas, subcarrier intervals, and subcarrier groupings, with limited channel knowledge required by the transmit antennas. The optimization process of the rate one MRP is simple and easily visualized so that the optimal rotation angle can be derived explicitly, or even intuitively for some cases. The multirate MRP has a complex optimization process, but it has a better spectral efficiency and provides a relatively smooth balance between system performance and transmission rate. Simulations show that the proposed SFBC with MRP can overcome the diversity loss for specific propagation scenarios, always improve the system performance, and demonstrate flexible performance with large performance gain. Therefore the proposed SFBCs with MRP demonstrate flexibility and feasibility so that it is more suitable for a practical MIMO-OFDM system with dynamic parameters.

  13. Space-Frequency Block Code with Matched Rotation for MIMO-OFDM System with Limited Feedback

    Science.gov (United States)

    Zhang, Min; Abhayapala, Thushara D.; Jayalath, Dhammika; Smith, David; Athaudage, Chandra

    2009-12-01

    This paper presents a novel matched rotation precoding (MRP) scheme to design a rate one space-frequency block code (SFBC) and a multirate SFBC for MIMO-OFDM systems with limited feedback. The proposed rate one MRP and multirate MRP can always achieve full transmit diversity and optimal system performance for arbitrary number of antennas, subcarrier intervals, and subcarrier groupings, with limited channel knowledge required by the transmit antennas. The optimization process of the rate one MRP is simple and easily visualized so that the optimal rotation angle can be derived explicitly, or even intuitively for some cases. The multirate MRP has a complex optimization process, but it has a better spectral efficiency and provides a relatively smooth balance between system performance and transmission rate. Simulations show that the proposed SFBC with MRP can overcome the diversity loss for specific propagation scenarios, always improve the system performance, and demonstrate flexible performance with large performance gain. Therefore the proposed SFBCs with MRP demonstrate flexibility and feasibility so that it is more suitable for a practical MIMO-OFDM system with dynamic parameters.

  14. Validity of a surveillance system for childhood injuries in a rural block of Tamilnadu

    Directory of Open Access Journals (Sweden)

    Sivamani M

    2009-01-01

    Full Text Available Background: Childhood injuries are increasingly getting the attention of public health experts following WHO′s report on global burden of diseases. Surveillance is an important component of control of any disease and effectiveness of the surveillance system depends upon completeness of the information about occurrence of the health related events to the public health authorities. Aims: This study aimed to set up a surveillance system for childhood injuries and validate it by a survey and thereafter estimate the incidence of childhood injuries using capture recapture method. Settings and Design: Observational study design. Materials and Methods: Passive surveillance system for childhood injuries was created for 26,811 children of less than fourteen years of Kaniyambadi block and it was validated by cross sectional study at the end of surveillance period. Using these two independent information systems, capture recapture method was applied to find out the possible incidence of injuries in the given population at a given period of time. Statistics: Chi square, Lincoln Peterson formula for capture re-capture method. Results: Surveillance and survey for childhood injuries identified 13.59/1000 child-years (CI: 11.86 -15.32 and 341.89/1000 child-years (CI: 254.46-429.33 of injury rates, respectively. Conclusion: Passive surveillance system underreports childhood injuries markedly but it does identify childhood injuries of serious nature.

  15. Systemic Acquired Resistance and Signal Transduction in Plant

    Institute of Scientific and Technical Information of China (English)

    ZHAO Shu-qing; GUO Jian-bo

    2003-01-01

    Systemic acquired resistance (SAR), known as the broad-spectrum, inducible plant immunity,is a defense response triggered by pathogen infection. The response starts from the recognition of plant resist-ance (R) with the corresponding avirulence (avr) gene from the pathogen. There are some genes for conver-gence of signals downstream of different R/avr interacting partners into a single signaling pathway. Salicylicacid (SA) is required for the induction of SAR and involved in transducing the signal in target tissues. The SAsignal is transduced through NPR1, a nuclear-localized protein that interacts with transcription factors thatare involved in regulating SA-mediated gene expression. Some chemicals that mimic natural signaling com-pounds can also activate SAR. The application of biochemical activators to agriculture for plant protection is anovel idea for developing green chemical pesticide.

  16. S100A7-downregulation inhibits epidermal growth factor-induced signaling in breast cancer cells and blocks osteoclast formation.

    Directory of Open Access Journals (Sweden)

    Vikram Paruchuri

    Full Text Available S100A7 is a small calcium binding protein, which has been shown to be differentially expressed in psoriatic skin lesions, as well as in squamous cell tumors of the skin, lung and breast. Although its expression has been correlated to HER+ high-grade tumors and to a high risk of progression, the molecular mechanisms of these S100A7-mediated tumorigenic effects are not well known. Here, we showed for the first time that epidermal growth factor (EGF induces S100A7 expression in both MCF-7 and MDA-MB-468 cell lines. We also observed a decrease in EGF-directed migration in shRNA-downregulated MDA-MB-468 cell lines. Furthermore, our signaling studies revealed that EGF induced simultaneous EGF receptor phosphorylation at Tyr1173 and HER2 phosphorylation at Tyr1248 in S100A7-downregulated cell lines as compared to the vector-transfected controls. In addition, reduced phosphorylation of Src at tyrosine 416 and p-SHP2 at tyrosine 542 was observed in these downregulated cell lines. Further studies revealed that S100A7-downregulated cells had reduced angiogenesis in vivo based on matrigel plug assays. Our results also showed decreased tumor-induced osteoclastic resorption in an intra-tibial bone injection model involving SCID mice. S100A7-downregulated cells had decreased osteoclast number and size as compared to the vector controls, and this decrease was associated with variations in IL-8 expression in in vitro cell cultures. This is a novel report on the role of S100A7 in EGF-induced signaling in breast cancer cells and in osteoclast formation.

  17. 1st International Conference on Signal, Networks, Computing, and Systems

    CERN Document Server

    Mohapatra, Durga; Nagar, Atulya; Sahoo, Manmath

    2016-01-01

    The book is a collection of high-quality peer-reviewed research papers presented in the first International Conference on Signal, Networks, Computing, and Systems (ICSNCS 2016) held at Jawaharlal Nehru University, New Delhi, India during February 25–27, 2016. The book is organized in to two volumes and primarily focuses on theory and applications in the broad areas of communication technology, computer science and information security. The book aims to bring together the latest scientific research works of academic scientists, professors, research scholars and students in the areas of signal, networks, computing and systems detailing the practical challenges encountered and the solutions adopted.

  18. Wearable System for Acquisition and Monitoring of Biological Signals

    Science.gov (United States)

    Piccinini, D. J.; Andino, N. B.; Ponce, S. D.; Roberti, MA; López, y. N.

    2016-04-01

    This paper presents a modular, wearable system for acquisition and wireless transmission of biological signals. Configurable slaves for different signals (such as ECG, EMG, inertial sensors, and temperature) based in the ADS1294 Medical Analog Front End are connected to a Master, based in the CC3200 microcontroller, both from Texas Instruments. The slaves are configurable according to the specific application, providing versatility to the wearable system. The battery consumption is reduced, through a couple of Li-ion batteries and the circuit has also a battery charger. A custom made box was designed and fabricated in a 3D printer, preserving the requirements of low cost, low weight and safety recommendations.

  19. Multiple solutions to dense systems in radar scattering using a preconditioned block GMRES solver

    Energy Technology Data Exchange (ETDEWEB)

    Boyse, W.E. [Advanced Software Resources, Inc., Santa Clara, CA (United States)

    1996-12-31

    Multiple right-hand sides occur in radar scattering calculations in the computation of the simulated radar return from a body at a large number of angles. Each desired angle requires a right-hand side vector to be computed and the solution generated. These right-hand sides are naturally smooth functions of the angle parameters and this property is utilized in a novel way to compute solutions an order of magnitude faster than LINPACK The modeling technique addressed is the Method of Moments (MOM), i.e. a boundary element method for time harmonic Maxwell`s equations. Discretization by this method produces general complex dense systems of rank 100`s to 100,000`s. The usual way to produce the required multiple solutions is via LU factorization and solution routines such as found in LINPACK. Our method uses the block GMRES iterative method to directly iterate a subset of the desired solutions to convergence.

  20. Signal Adaptive System for Space/Spatial-Frequency Analysis

    Directory of Open Access Journals (Sweden)

    Veselin N. Ivanović

    2009-01-01

    Full Text Available This paper outlines the development of a multiple-clock-cycle implementation (MCI of a signal adaptive two-dimensional (2D system for space/spatial-frequency (S/SF signal analysis. The design is based on a method for improved S/SF representation of the analyzed 2D signals, also proposed here. The proposed MCI design optimizes critical design performances related to hardware complexity, making it a suitable system for real time implementation on an integrated chip. Additionally, the design allows the implemented system to take a variable number of clock cycles (CLKs (the only necessary ones regarding desirable—2D Wigner distribution-presentation of autoterms in different frequency-frequency points during the execution. This ability represents a major advantage of the proposed design which helps to optimize the time required for execution and produce an improved, cross-terms-free S/SF signal representation. The design has been verified by a field-programmable gate array (FPGA circuit design, capable of performing S/SF analysis of 2D signals in real time.

  1. Phosphoproteomics-based systems analysis of signal transduction networks

    Directory of Open Access Journals (Sweden)

    Hiroko eKozuka-Hata

    2012-01-01

    Full Text Available Signal transduction systems coordinate complex cellular information to regulate biological events such as cell proliferation and differentiation. Although the accumulating evidence on widespread association of signaling molecules has revealed essential contribution of phosphorylation-dependent interaction networks to cellular regulation, their dynamic behavior is mostly yet to be analyzed. Recent technological advances regarding mass spectrometry-based quantitative proteomics have enabled us to describe the comprehensive status of phosphorylated molecules in a time-resolved manner. Computational analyses based on the phosphoproteome dynamics accelerate generation of novel methodologies for mathematical analysis of cellular signaling. Phosphoproteomics-based numerical modeling can be used to evaluate regulatory network elements from a statistical point of view. Integration with transcriptome dynamics also uncovers regulatory hubs at the transcriptional level. These omics-based computational methodologies, which have firstly been applied to representative signaling systems such as the epidermal growth factor receptor pathway, have now opened up a gate for systems analysis of signaling networks involved in immune response and cancer.

  2. Digital Signal Processing for In-Vehicle Systems and Safety

    CERN Document Server

    Boyraz, Pinar; Takeda, Kazuya; Abut, Hüseyin

    2012-01-01

    Compiled from papers of the 4th Biennial Workshop on DSP (Digital Signal Processing) for In-Vehicle Systems and Safety this edited collection features world-class experts from diverse fields focusing on integrating smart in-vehicle systems with human factors to enhance safety in automobiles. Digital Signal Processing for In-Vehicle Systems and Safety presents new approaches on how to reduce driver inattention and prevent road accidents. The material addresses DSP technologies in adaptive automobiles, in-vehicle dialogue systems, human machine interfaces, video and audio processing, and in-vehicle speech systems. The volume also features: Recent advances in Smart-Car technology – vehicles that take into account and conform to the driver Driver-vehicle interfaces that take into account the driving task and cognitive load of the driver Best practices for In-Vehicle Corpus Development and distribution Information on multi-sensor analysis and fusion techniques for robust driver monitoring and driver recognition ...

  3. Power optimization in wearable biomedical systems: a signal processing perspective

    Science.gov (United States)

    Ghasemzadeh, Hassan

    2012-10-01

    Wearable monitoring systems have caught considerable attention recently due to their potential in many domains including smart health and well-being. These new biomedical monitoring systems aim to provide continuous patient monitoring and proactive care options. Realization of this vision requires research that addresses a number of challenges, in particular, regarding limited resources that the wearable sensor networks offer. This paper presents an overview of different strategies for prolonging system lifetimes through power optimization in such systems. Particular emphasis is given to enhancing processing and communication architectures with respect to the signal processing requirements of the system.

  4. Advances in signal processing and intelligent recognition systems

    CERN Document Server

    Gelbukh, Alexander; Mukhopadhyay, Jayanta

    2014-01-01

    This Edited Volume contains a selection of refereed and revised papers originally presented at the International Symposium on Signal Processing and Intelligent Recognition Systems (SIRS-2014), March 13-15, 2014, Trivandrum, India. The program committee received 134 submissions from 11 countries. Each paper was peer reviewed by at least three or more independent referees of the program committee and the 52 papers were finally selected. The papers offer stimulating insights into Pattern Recognition, Machine Learning and Knowledge-Based Systems; Signal and Speech Processing; Image and Video Processing; Mobile Computing and Applications and Computer Vision. The book is directed to the researchers and scientists engaged in various field of signal processing and related areas.  

  5. Light relations and performance of signal grass in silvopastoral system

    OpenAIRE

    Cynara Oliveira Diniz Rodrigues; Saulo Alberto do Carmo Araújo; Maria Celuta Machado Viana; Norberto Silva Rocha; Thiago Gomes dos Santos Braz; Severino Delmar Junqueira Villela

    2014-01-01

    The aim was to evaluate the influence of different spatial arrangements of trees [(3×2)×20 m, (2×2)×9 m and 2×9 m] and sampling sites (center of row spacing and side of tree rows) with regard to the amount and quality of light in the understory of silvopastoral systems and their effects on the production and chemical composition of pasture. The experimental design was a randomized block in a split plot, with three replications. The sampling site affected absolute irradiance, photosynthetic ac...

  6. Analysis of the call blocking rate of two-hop-relay cellular system in the dead spots

    Institute of Scientific and Technical Information of China (English)

    LU Wei-feng; WU Meng

    2007-01-01

    In a traditional cellular system, the call requests initiated by mobile stations (MSs) must be carried through a base station (BS) via the cellular interface, but when MSs are located in the dead spots, their call requests will be blocked because the MSs cannot communicate with the BS. It is considered to relay these blocked calls requested using Ad-hoc network, which will improve the performance of the system as a whole. This article first introduces a novel architecture of the two-hop-relay cellular system in the dead spots, and then analyzes and compares the call blocking rate of the traditional cellular and the two-hop-relay cellular system respectively under three different conditions. The first and second conditions are the traditional cellular system without and with taking account of the effect of the dead spots. The third condition is the two-hop-relay cellular system with taking account of the effect of the dead spots. Numerical analytical result shows that the two-hop-relay cellular system can obtain lower call blocking rate than the traditional cellular system when considering the effect of dead spots. Consequently, this novel architecture can resolve the problem of coverage limitation of a traditional cellular system effectively.

  7. Cancer systems biology: signal processing for cancer research

    Institute of Scientific and Technical Information of China (English)

    Olli Yli-Harja; Antti Ylip(a)(a); Matti Nykter; Wei Zhang

    2011-01-01

    In this editorial we introduce the research paradigms of signal processing in the era of systems biology. Signal processing is a field of science traditionally focused on modeling electronic and communications systems, but recently it has turned to biological applications with astounding results. The essence of signal processing is to describe the natural world by mathematical models and then, based on these models, develop efficient computational tools for solving engineering problems. Here, we underline, with examples, the endless possibilities which arise when the battle-hardened tools of engineering are applied to solve the problems that have tormented cancer researchers. Based on this approach, a new field has emerged, called cancer systems biology. Despite its short history, cancer systems biology has already produced several success stories tackling previously impracticable problems. Perhaps most importantly, it has been accepted as an integral part of the major endeavors of cancer research, such as analyzing the genomic and epigenomic data produced by The Cancer Genome Atlas (TCGA) project. Finally, we show that signal processing and cancer research, two fields that are seemingly distant from each other, have merged into a field that is indeed more than the sum of its parts.

  8. Synthetic modular systems--reverse engineering of signal transduction

    DEFF Research Database (Denmark)

    Pawson, Tony; Linding, Rune

    2005-01-01

    to a deeper and more abstract understanding of signal transduction systems. Designing and successfully introducing synthetic proteins into cellular pathways would provide us with a powerful research tool with many applications, such as development of biosensors, protein drugs and rewiring of biological...

  9. Linear System Models for Ultrasonic Imaging: Application to Signal Statistics

    Science.gov (United States)

    Zemp, Roger J.; Abbey, Craig K.; Insana, Michael F.

    2009-01-01

    Linear equations for modeling echo signals from shift-variant systems forming ultrasonic B-mode, Doppler, and strain images are analyzed and extended. The approach is based on a solution to the homogeneous wave equation for random inhomogeneous media. When the system is shift-variant, the spatial sensitivity function—defined as a spatial weighting function that determines the scattering volume for a fixed point of time—has advantages over the point-spread function traditionally used to analyze ultrasound systems. Spatial sensitivity functions are necessary for determining statistical moments in the context of rigorous image quality assessment, and they are time-reversed copies of point-spread functions for shift variant systems. A criterion is proposed to assess the validity of a local shift-invariance assumption. The analysis reveals realistic situations in which in-phase signals are correlated to the corresponding quadrature signals, which has strong implications for assessing lesion detectability. Also revealed is an opportunity to enhance near- and far-field spatial resolution by matched filtering unfocused beams. The analysis connects several well-known approaches to modeling ultrasonic echo signals. PMID:12839176

  10. Cancer systems biology: signal processing for cancer research.

    Science.gov (United States)

    Yli-Harja, Olli; Ylipää, Antti; Nykter, Matti; Zhang, Wei

    2011-04-01

    In this editorial we introduce the research paradigms of signal processing in the era of systems biology. Signal processing is a field of science traditionally focused on modeling electronic and communications systems, but recently it has turned to biological applications with astounding results. The essence of signal processing is to describe the natural world by mathematical models and then, based on these models, develop efficient computational tools for solving engineering problems. Here, we underline, with examples, the endless possibilities which arise when the battle-hardened tools of engineering are applied to solve the problems that have tormented cancer researchers. Based on this approach, a new field has emerged, called cancer systems biology. Despite its short history, cancer systems biology has already produced several success stories tackling previously impracticable problems. Perhaps most importantly, it has been accepted as an integral part of the major endeavors of cancer research, such as analyzing the genomic and epigenomic data produced by The Cancer Genome Atlas (TCGA) project. Finally, we show that signal processing and cancer research, two fields that are seemingly distant from each other, have merged into a field that is indeed more than the sum of its parts.

  11. Z-guggulsterone negatively controls microglia-mediated neuroinflammation via blocking IκB-α-NF-κB signals.

    Science.gov (United States)

    Huang, Chao; Wang, Jili; Lu, Xu; Hu, Wenfeng; Wu, Feng; Jiang, Bo; Ling, Yong; Yang, Rongrong; Zhang, Wei

    2016-04-21

    Induction of pro-inflammatory factors is one of the characteristics of microglial activation and can be regulated by numerous active agents extracted from plants. Suppression of pro-inflammatory factors is beneficial to alleviate neuroinflammation. Z-guggulsterone, a compound extracted from the gum resin of the tree commiphora mukul, exhibits numerous anti-inflammatory effects. However, the role and mechanism of Z-guggulsterone in pro-inflammatory responses in microglia remains unclear. This study addressed this issue in in vitro murine microglia and in vivo neuroinflammation models. Results showed that Z-guggulsterone reduced inducible nitric oxide (iNOS) protein expression as well as nitric oxide (NO), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) production in LPS-stimulated BV-2 cells. Z-guggulsterone also reduced the mRNA level of iNOS, TNF-α, and IL-6. Mechanistic studies revealed that Z-guggulsterone attenuated the LPS-induced degradation of inhibitor κ B-α (IκB-α) as well as the LPS-induced nuclear translocation of nuclear factor-κB (NF-κB). Z-guggulsterone, however, failed to reduce the LPS-induced increase in NF-κB phosphorylation level. These major findings were ascertained in primary microglia where the LPS-induced increases in iNOS expression, NO content, and IκB-α degradation were diminished by Z-guggulsterone treatment. In a mouse model of neuroinflammation, Z-guggulsterone exhibited significant anti-inflammatory effects, which were exemplified by the attenuation of microglial activation and neuroinflammation-induced behavioral abnormalities in Z-guggulsterone-treated mice. Taken together, these studies demonstrate that Z-guggulsterone attenuates the LPS-mediated induction of pro-inflammatory factors in microglia via inhibition of IκB-α-NF-κB signals, providing evidence to uncover the potential role of Z-guggulsterone in neuroinflammation-associated disorder therapies.

  12. Dose-response aligned circuits in signaling systems.

    Directory of Open Access Journals (Sweden)

    Long Yan

    Full Text Available Cells use biological signal transduction pathways to respond to environmental stimuli and the behavior of many cell types depends on precise sensing and transmission of external information. A notable property of signal transduction that was characterized in the Saccharomyces cerevisiae yeast cell and many mammalian cells is the alignment of dose-response curves. It was found that the dose response of the receptor matches closely the dose responses of the downstream. This dose-response alignment (DoRA renders equal sensitivities and concordant responses in different parts of signaling system and guarantees a faithful information transmission. The experimental observations raise interesting questions about the nature of the information transmission through DoRA signaling networks and design principles of signaling systems with this function. Here, we performed an exhaustive computational analysis on network architectures that underlie the DoRA function in simple regulatory networks composed of two and three enzymes. The minimal circuits capable of DoRA were examined with Michaelis-Menten kinetics. Several motifs that are essential for the dynamical function of DoRA were identified. Systematic analysis of the topology space of robust DoRA circuits revealed that, rather than fine-tuning the network's parameters, the function is primarily realized by enzymatic regulations on the controlled node that are constrained in limiting regions of saturation or linearity.

  13. Fixed-complexity vector perturbation with Block diagonalization for MU-MIMO systems

    CERN Document Server

    Mohaisen, Manar; Chang, KyungHi; Ji, Seunghwan; Joung, Jinsoup

    2009-01-01

    Block diagonalization (BD) is an attractive technique that transforms the multi-user multiple-input multiple-output (MU-MIMO) channel into parallel single-user MIMO (SU-MIMO) channels with zero inter-user interference (IUI). In this paper, we combine the BD technique with two deterministic vector perturbation (VP) algorithms that reduce the transmit power in MU-MIMO systems with linear precoding. These techniques are the fixed-complexity sphere encoder (FSE) and the QR-decomposition with M-algorithm encoder (QRDM-E). In contrast to the conventional BD VP technique, which is based on the sphere encoder (SE), the proposed techniques have fixed complexity and a tradeoff between performance and complexity can be achieved by controlling the size of the set of candidates for the perturbation vector. Simulation results and analysis demonstrate the properness of the proposed techniques for the next generation mobile communications systems which are latency and computational complexity limited. In MU-MIMO system with ...

  14. Conduction block in the peripheral nervous system in experimental allergic encephalomyelitis

    Science.gov (United States)

    Pender, M. P.; Sears, T. A.

    1982-04-01

    Experimental allergic encephalomyelitis (EAE) has been widely studied as a model of multiple sclerosis, a central nervous system (CNS) disease of unknown aetiology. The clinical features of both EAE and multiple sclerosis provide the only guide to the progress and severity of these diseases, and are used to assess the response to treatment. In such comparisons the clinical features of EAE are assumed to be due to lesions in the CNS, but in this disease there is also histological evidence of damage to the peripheral nervous system1-8. However, the functional consequences of such peripheral lesions have been entirely ignored. To examine this we have studied nerve conduction in rabbits with EAE. We report here that most of the large diameter afferent fibres are blocked in the region of the dorsal root ganglion and at the dorsal root entry zone, thus accounting for the loss of tendon jerks and also, through the severe loss of proprioceptive information, the ataxia of these animals. We conclude that whenever clinical comparisons are made between EAE and multiple sclerosis, the pathophysiology associated with the histological damage of the peripheral nervous system must be taken into account.

  15. Hierarchically Ordered Polymer/Block Copolymer/Nanoparticle Systems Enabled via Holographic Photopolymerization

    Science.gov (United States)

    Bunning, Timothy

    2010-03-01

    Combining top-down and bottom-up methods in one process step creates novel hierarchical nanostructures with tailored properties. We demonstrate the ability to spatially pattern block copolymers or nanoparticles into periodic volume gratings using a one-step holographic patterning (HP) technique. The confinement of the second phase (e.g. block copolymer or nanoparticle) within the grating results in local preferential ordering of that phase, enabling single-step fabrication of complex hierarchical structures. As an example, this simple interfering photopolymer `writing' technique was utilized to generate a layer-in-layer structure of poly(ethylene oxide-b-epsilon-caprolactone) confined between crosslinked resin. The period of the volume grating was 200 nm, with the BCP occupying 100 nm of the 1-D structure. The BCP crystallized/phase separated to produce a lamellar structure with a 21 nm periodicity. This system exhibits interesting thermo-optical behavior during heating/cooling cycles. Alternatively, a layered polymer/nanoparticle composite was created through a one-step two-beam interference lithographic exposure of a dispersion of silica nanoparticles within a photopolymerizable mixture at a wavelength of 532 nm. The effects of exposure time and power, nanoparticle size, and periodicity on the nanocomposite structure were measured with transmission electron microscopy. The optical properties of the formed gratings were probed in real-time during formation. Collaborators on this work include M. Birnkrant and C. Li from Drexel University, A. Juhl and P. Braun from UIUC, and L. Natarajan, V. Tondiglia, and R. Vaia from AFRL.

  16. Increased noise signal processing in incoherent radar systems

    Directory of Open Access Journals (Sweden)

    I. I. Chesanovskyi

    2013-09-01

    Full Text Available Introduction. The work is devoted to the method of increasing coherence and noise immunity pulse radar systems with incoherent sources probing signals. Problem. Incongruities between a resolution and a range of pulsed radar systems can not be resolved within the classical approaches of building incoherent radar systems, requiring new approaches in their construction. The main part. The paper presents a method of two-stage processing incoherent pulsed radar signals, allowing to compensate and use the information available to them and the angular amplitude of spurious modulation. Conclusions. Simulation results and research functions of these expressions of uncertainty indicate that use volatility as an additional transmitter modulation allows to significantly improve the resolution and robustness of the radar system.

  17. Systemic Nutrient and Stress Signaling via Myokines and Myometabolites.

    Science.gov (United States)

    Rai, Mamta; Demontis, Fabio

    2016-01-01

    Homeostatic systems mount adaptive responses to meet the energy demands of the cell and to compensate for dysfunction in cellular compartments. Such surveillance systems are also active at the organismal level: Nutrient and stress sensing in one tissue can lead to changes in other tissues. Here, we review the emerging understanding of the role of skeletal muscle in regulating physiological homeostasis and disease progression in other tissues. Muscle-specific genetic interventions can induce systemic effects indirectly, via changes in the mass and metabolic demand of muscle, and directly, via the release of muscle-derived cytokines (myokines) and metabolites (myometabolites) in response to nutrients and stress. In turn, myokines and myometabolites signal to various target tissues in an autocrine, paracrine, and endocrine manner, thereby determining organismal resilience to aging, disease, and environmental challenges. We propose that tailoring muscle systemic signaling by modulating myokine and myometabolite levels may combat many degenerative diseases and delay aging. PMID:26527185

  18. Correlation between peak and median blocking temperatures by magnetization measurement on isolated ferromagnetic and antiferromagnetic particle systems

    DEFF Research Database (Denmark)

    Jiang, Jianzhong; Mørup, Steen

    1997-01-01

    The influence of the particle size distribution on the ratio of the peak temperature, T-peak, to the blocking temperature, T-Bm, in zero field cooled (ZFD) magnetization curves has studied for both ferromagnetic and antiferromagnetic particle systems. In both systems the ratio beta=T-peak/T-Bm does...

  19. Anti-Inflammatory Effects of Cumin Essential Oil by Blocking JNK, ERK, and NF-κB Signaling Pathways in LPS-Stimulated RAW 264.7 Cells

    Directory of Open Access Journals (Sweden)

    Juan Wei

    2015-01-01

    Full Text Available Cumin seeds (Cuminum cyminum L. have been commonly used in food flavoring and perfumery. In this study, cumin essential oil (CuEO extracted from seeds was employed to investigate the anti-inflammatory effects in lipopolysaccharide- (LPS- stimulated RAW 264.7 cells and the underlying mechanisms. A total of 26 volatile constituents were identified in CuEO by GC-MS, and the most abundant constituent was cuminaldehyde (48.773%. Mitochondrial-respiration-dependent 3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium (MTT reduction assay demonstrated that CuEO did not exhibit any cytotoxic effect at the employed concentrations (0.0005–0.01%. Real-time PCR tests showed that CuEO significantly inhibited the mRNA expressions of inducible nitric oxide synthase (iNOS, cyclooxygenase (COX-2, interleukin- (IL- 1, and IL-6. Moreover, western blotting analysis revealed that CuEO blocked LPS-induced transcriptional activation of nuclear factor-kappa B (NF-κB and inhibited the phosphorylation of extracellular signal regulated kinase (ERK and c-Jun N-terminal kinase (JNK. These results suggested that CuEO exerted anti-inflammatory effects in LPS-stimulated RAW 264.7 cells via inhibition of NF-κB and mitogen-activated protein kinases ERK and JNK signaling; the chemical could be used as a source of anti-inflammatory agents as well as dietary complement for health promotion.

  20. Anti-Inflammatory Effects of Cumin Essential Oil by Blocking JNK, ERK, and NF-κB Signaling Pathways in LPS-Stimulated RAW 264.7 Cells.

    Science.gov (United States)

    Wei, Juan; Zhang, Xitong; Bi, Yang; Miao, Ruidong; Zhang, Zhong; Su, Hailan

    2015-01-01

    Cumin seeds (Cuminum cyminum L.) have been commonly used in food flavoring and perfumery. In this study, cumin essential oil (CuEO) extracted from seeds was employed to investigate the anti-inflammatory effects in lipopolysaccharide- (LPS-) stimulated RAW 264.7 cells and the underlying mechanisms. A total of 26 volatile constituents were identified in CuEO by GC-MS, and the most abundant constituent was cuminaldehyde (48.773%). Mitochondrial-respiration-dependent 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) reduction assay demonstrated that CuEO did not exhibit any cytotoxic effect at the employed concentrations (0.0005-0.01%). Real-time PCR tests showed that CuEO significantly inhibited the mRNA expressions of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2), interleukin- (IL-) 1, and IL-6. Moreover, western blotting analysis revealed that CuEO blocked LPS-induced transcriptional activation of nuclear factor-kappa B (NF-κB) and inhibited the phosphorylation of extracellular signal regulated kinase (ERK) and c-Jun N-terminal kinase (JNK). These results suggested that CuEO exerted anti-inflammatory effects in LPS-stimulated RAW 264.7 cells via inhibition of NF-κB and mitogen-activated protein kinases ERK and JNK signaling; the chemical could be used as a source of anti-inflammatory agents as well as dietary complement for health promotion. PMID:26425131

  1. Blocking Epidermal Growth Factor Receptor Signaling in HTR-8/SVneo First Trimester Trophoblast Cells Results in Dephosphorylation of PKBα/AKT and Induces Apoptosis

    Directory of Open Access Journals (Sweden)

    J. Bolnick

    2011-01-01

    Full Text Available We identified a major peptide signaling target of EGF/EGFR pathway and explored the consequences of blocking or activating this pathway in the first trimester extravillous trophoblast cells, HTR-8/SVneo. A global analysis of protein phosphorylation was undertaken using novel technology (Kinexus Kinetworks that utilizes SDS-polyacrylamide minigel electrophoresis and multi-lane immunoblotting to permit specific and semiquantitative detection of multiple phosphoproteins. Forty-seven protein phosphorylation sites were queried, and the results reported based on relative phosphorylation at each site. EGF- and Iressa-(gefitinib, ZD1839, an inhibitor of EGFR treated HTR-8/SVneo cells were subjected to immunoblotting and flow cytometry to confirm the phosphoprotein screen and to assess the effects of EGF versus Iressa on cell cycle and apoptosis. EGFR mediates the phosphorylation of important signaling proteins, including PKBα/AKT. This pathway is likely to be central to EGFR-mediated trophoblast survival. Furthermore, EGF treatment induces proliferation and inhibits apoptosis, while Iressa induces apoptosis.

  2. Signal distortion from microelectrodes in clinical EEG acquisition systems

    Science.gov (United States)

    Stacey, William C.; Kellis, Spencer; Patel, Paras R.; Greger, Bradley; Butson, Christopher R.

    2012-10-01

    Many centers are now using high-density microelectrodes during traditional intracranial electroencephalography (iEEG) both for research and clinical purposes. These microelectrodes are FDA-approved and integrate into clinical EEG acquisition systems. However, the electrical characteristics of these electrodes are poorly described and clinical systems were not designed to use them; thus, it is possible that this shift into clinical practice could have unintended consequences. In this study, we characterized the impedance of over 100 commercial macro- and microelectrodes using electrochemical impedance spectroscopy (EIS) to determine how electrode properties could affect signal acquisition and interpretation. The EIS data were combined with the published specifications of several commercial EEG systems to design digital filters that mimic the behavior of the electrodes and amplifiers. These filters were used to analyze simulated brain signals that contain a mixture of characteristic features commonly observed in iEEG. Each output was then processed with several common quantitative EEG measurements. Our results show that traditional macroelectrodes had low impedances and produced negligible distortion of the original signal. Brain tissue and electrical wiring also had negligible filtering effects. However, microelectrode impedances were much higher and more variable than the macroelectrodes. When connected to clinical amplifiers, higher impedance electrodes produced considerable distortion of the signal at low frequencies (60 Hz), which caused significant changes in amplitude, phase, variance and spectral band power. In contrast, there were only minimal changes to the signal content for frequencies above 100 Hz. In order to minimize distortion with microelectrodes, we determined that an acquisition system should have an input impedance of at least 1 GΩ, which is much higher than most clinical systems. These results show that it is critical to account for variations

  3. Coding and signal processing for magnetic recording systems

    CERN Document Server

    Vasic, Bane

    2004-01-01

    RECORDING SYSTEMSA BriefHistory of Magnetic Storage, Dean PalmerPhysics of Longitudinal and Perpendicular Recording, Hong Zhou, Tom Roscamp, Roy Gustafson, Eric Boernern, and Roy ChantrellThe Physics of Optical Recording, William A. Challener and Terry W. McDanielHead Design Techniques for Recording Devices, Robert E. RottmayerCOMMUNICATION AND INFORMATION THEORY OF MAGNETIC RECORDING CHANNELSModeling the Recording Channel, Jaekyun MoonSignal and Noise Generation for Magnetic Recording Channel Simulations, Xueshi Yang and Erozan M. KurtasStatistical Analysis of Digital Signals and Systems, Dra

  4. Joint Polar Satellite System (JPSS) Common Ground System (CGS) Block 3.0 Communications Strategies

    Science.gov (United States)

    Miller, S. W.; Grant, K. D.; Ottinger, K.

    2015-12-01

    The National Oceanic and Atmospheric Administration (NOAA) and National Aeronautics and Space Administration (NASA) are jointly acquiring the next-generation civilian weather and environmental satellite system: the Joint Polar Satellite System (JPSS). The JPSS program is the follow-on for both space and ground systems to the Polar-orbiting Operational Environmental Satellites (POES) managed by NOAA. The JPSS satellites will carry a suite of sensors designed to collect meteorological, oceanographic, climatological and geophysical observations of the Earth. The ground processing system for JPSS is known as the JPSS Common Ground System (JPSS CGS). Developed and maintained by Raytheon Intelligence, Information and Services (IIS), the CGS is a globally distributed, multi-mission system serving NOAA, NASA and their national and international partners. The CGS has demonstrated its scalability and flexibility to incorporate multiple missions efficiently and with minimal cost, schedule and risk, while strengthening global partnerships in weather and environmental monitoring. In a highly successful international partnership between NOAA and the European Organisation for the Exploitation of Meteorological Satellites (EUMETSAT), the CGS currently provides data routing from McMurdo Station in Antarctica to the EUMETSAT processing center in Darmstadt, Germany. Continuing and building upon that partnership, NOAA and EUMETSAT are collaborating on the development of a new path forward for the 2020's. One approach being explored is a concept of operations where each organization shares satellite downlink resources with the other. This paper will describe that approach, as well as modeling results that demonstrate its feasibility and expected performance.

  5. Optimizing Blocking and Nonblocking Reduction Operations for Multicore Systems: Hierarchical Design and Implementation

    Energy Technology Data Exchange (ETDEWEB)

    Gorentla Venkata, Manjunath [ORNL; Shamis, Pavel [ORNL; Graham, Richard L [ORNL; Ladd, Joshua S [ORNL; Sampath, Rahul S [ORNL

    2013-01-01

    Many scientific simulations, using the Message Passing Interface (MPI) programming model, are sensitive to the performance and scalability of reduction collective operations such as MPI Allreduce and MPI Reduce. These operations are the most widely used abstractions to perform mathematical operations over all processes that are part of the simulation. In this work, we propose a hierarchical design to implement the reduction operations on multicore systems. This design aims to improve the efficiency of reductions by 1) tailoring the algorithms and customizing the implementations for various communication mechanisms in the system 2) providing the ability to configure the depth of hierarchy to match the system architecture, and 3) providing the ability to independently progress each of this hierarchy. Using this design, we implement MPI Allreduce and MPI Reduce operations (and its nonblocking variants MPI Iallreduce and MPI Ireduce) for all message sizes, and evaluate on multiple architectures including InfiniBand and Cray XT5. We leverage and enhance our existing infrastructure, Cheetah, which is a framework for implementing hierarchical collective operations to implement these reductions. The experimental results show that the Cheetah reduction operations outperform the production-grade MPI implementations such as Open MPI default, Cray MPI, and MVAPICH2, demonstrating its efficiency, flexibility and portability. On Infini- Band systems, with a microbenchmark, a 512-process Cheetah nonblocking Allreduce and Reduce achieves a speedup of 23x and 10x, respectively, compared to the default Open MPI reductions. The blocking variants of the reduction operations also show similar performance benefits. A 512-process nonblocking Cheetah Allreduce achieves a speedup of 3x, compared to the default MVAPICH2 Allreduce implementation. On a Cray XT5 system, a 6144-process Cheetah Allreduce outperforms the Cray MPI by 145%. The evaluation with an application kernel, Conjugate

  6. A general U-block model-based design procedure for nonlinear polynomial control systems

    Science.gov (United States)

    Zhu, Q. M.; Zhao, D. Y.; Zhang, Jianhua

    2016-10-01

    The proposition of U-model concept (in terms of 'providing concise and applicable solutions for complex problems') and a corresponding basic U-control design algorithm was originated in the first author's PhD thesis. The term of U-model appeared (not rigorously defined) for the first time in the first author's other journal paper, which established a framework for using linear polynomial control system design approaches to design nonlinear polynomial control systems (in brief, linear polynomial approaches → nonlinear polynomial plants). This paper represents the next milestone work - using linear state-space approaches to design nonlinear polynomial control systems (in brief, linear state-space approaches → nonlinear polynomial plants). The overall aim of the study is to establish a framework, defined as the U-block model, which provides a generic prototype for using linear state-space-based approaches to design the control systems with smooth nonlinear plants/processes described by polynomial models. For analysing the feasibility and effectiveness, sliding mode control design approach is selected as an exemplary case study. Numerical simulation studies provide a user-friendly step-by-step procedure for the readers/users with interest in their ad hoc applications. In formality, this is the first paper to present the U-model-oriented control system design in a formal way and to study the associated properties and theorems. The previous publications, in the main, have been algorithm-based studies and simulation demonstrations. In some sense, this paper can be treated as a landmark for the U-model-based research from intuitive/heuristic stage to rigour/formal/comprehensive studies.

  7. Performance of a Heating Block System Designed for Studying the Heat Resistance of Bacteria in Foods.

    Science.gov (United States)

    Kou, Xiao-Xi; Li, Rui; Hou, Li-Xia; Huang, Zhi; Ling, Bo; Wang, Shao-Jin

    2016-07-28

    Knowledge of bacteria's heat resistance is essential for developing effective thermal treatments. Choosing an appropriate test method is important to accurately determine bacteria's heat resistances. Although being a major factor to influence the thermo-tolerance of bacteria, the heating rate in samples cannot be controlled in water or oil bath methods due to main dependence on sample's thermal properties. A heating block system (HBS) was designed to regulate the heating rates in liquid, semi-solid and solid foods using a temperature controller. Distilled water, apple juice, mashed potato, almond powder and beef were selected to evaluate the HBS's performance by experiment and computer simulation. The results showed that the heating rates of 1, 5 and 10 °C/min with final set-point temperatures and holding times could be easily and precisely achieved in five selected food materials. A good agreement in sample central temperature profiles was obtained under various heating rates between experiment and simulation. The experimental and simulated results showed that the HBS could provide a sufficiently uniform heating environment in food samples. The effect of heating rate on bacterial thermal resistance was evaluated with the HBS. The system may hold potential applications for rapid and accurate assessments of bacteria's thermo-tolerances.

  8. Performance of a Heating Block System Designed for Studying the Heat Resistance of Bacteria in Foods.

    Science.gov (United States)

    Kou, Xiao-Xi; Li, Rui; Hou, Li-Xia; Huang, Zhi; Ling, Bo; Wang, Shao-Jin

    2016-01-01

    Knowledge of bacteria's heat resistance is essential for developing effective thermal treatments. Choosing an appropriate test method is important to accurately determine bacteria's heat resistances. Although being a major factor to influence the thermo-tolerance of bacteria, the heating rate in samples cannot be controlled in water or oil bath methods due to main dependence on sample's thermal properties. A heating block system (HBS) was designed to regulate the heating rates in liquid, semi-solid and solid foods using a temperature controller. Distilled water, apple juice, mashed potato, almond powder and beef were selected to evaluate the HBS's performance by experiment and computer simulation. The results showed that the heating rates of 1, 5 and 10 °C/min with final set-point temperatures and holding times could be easily and precisely achieved in five selected food materials. A good agreement in sample central temperature profiles was obtained under various heating rates between experiment and simulation. The experimental and simulated results showed that the HBS could provide a sufficiently uniform heating environment in food samples. The effect of heating rate on bacterial thermal resistance was evaluated with the HBS. The system may hold potential applications for rapid and accurate assessments of bacteria's thermo-tolerances. PMID:27465120

  9. Performance of a Heating Block System Designed for Studying the Heat Resistance of Bacteria in Foods

    Science.gov (United States)

    Kou, Xiao-Xi; Li, Rui; Hou, Li-Xia; Huang, Zhi; Ling, Bo; Wang, Shao-Jin

    2016-07-01

    Knowledge of bacteria’s heat resistance is essential for developing effective thermal treatments. Choosing an appropriate test method is important to accurately determine bacteria’s heat resistances. Although being a major factor to influence the thermo-tolerance of bacteria, the heating rate in samples cannot be controlled in water or oil bath methods due to main dependence on sample’s thermal properties. A heating block system (HBS) was designed to regulate the heating rates in liquid, semi-solid and solid foods using a temperature controller. Distilled water, apple juice, mashed potato, almond powder and beef were selected to evaluate the HBS’s performance by experiment and computer simulation. The results showed that the heating rates of 1, 5 and 10 °C/min with final set-point temperatures and holding times could be easily and precisely achieved in five selected food materials. A good agreement in sample central temperature profiles was obtained under various heating rates between experiment and simulation. The experimental and simulated results showed that the HBS could provide a sufficiently uniform heating environment in food samples. The effect of heating rate on bacterial thermal resistance was evaluated with the HBS. The system may hold potential applications for rapid and accurate assessments of bacteria’s thermo-tolerances.

  10. Nonlinear optical signal processing for high-speed, spectrally efficient fiber optic systems and networks

    Science.gov (United States)

    Zhang, Bo

    The past decade has witnessed astounding boom in telecommunication network traffic. With the emergence of multimedia over Internet, the high-capacity optical transport systems have started to shift focus from the core network towards the end users. This trend leads to diverse optical networks with transparency and reconfigurability requirement. As single channel data rate continues to increase and channel spacing continues to shrink for high capacity, high spectral efficiency, the workload on conventional electronic signal processing elements in the router nodes continues to build up. Performing signal processing functions in the optical domain can potentially alleviate the speed bottleneck if the unique optical properties are efficiently leveraged to assist electronic processing methodologies. Ultra-high bandwidth capability along with the promise for multi-channel and format-transparent operation make optical signal processing an attractive technology which is expected to have great impact on future optical networks. For optical signal processing applications in fiber-optic network and systems, a laudable goal would be to explore the unique nonlinear optical processes in novel photonic devices. This dissertation investigates novel optical signal processing techniques through simulations and experimental demonstrations, analyzes limitations of these nonlinear processing elements and proposes techniques to enhance the system performance or designs for functional photonic modules. Two key signal-processing building blocks for future optical networks, namely slow-light-based tunable optical delay lines and SOA-based high-speed wavelength converters, are presented in the first part of the dissertation. Phase preserving and spectrally efficient slow light are experimentally demonstrated using advanced modulation formats. Functional and novel photonic modules, such as multi-channel synchronizer and variable-bit-rate optical time division multiplexer are designed and

  11. A Segmented Signal Progression Model for the Modern Streetcar System

    Directory of Open Access Journals (Sweden)

    Baojie Wang

    2015-01-01

    Full Text Available This paper is on the purpose of developing a segmented signal progression model for modern streetcar system. The new method is presented with the following features: (1 the control concept is based on the assumption of only one streetcar line operating along an arterial under a constant headway and no bandwidth demand for streetcar system signal progression; (2 the control unit is defined as a coordinated intersection group associated with several streetcar stations, and the control joints must be streetcar stations; (3 the objective function is built to ensure the two-way streetcar arrival times distributing within the available time of streetcar phase; (4 the available time of streetcar phase is determined by timing schemes, intersection structures, track locations, streetcar speeds, and vehicular accelerations; (5 the streetcar running speed is constant separately whether it is in upstream or downstream route; (6 the streetcar dwell time is preset according to historical data distribution or charging demand. The proposed method is experimentally examined in Hexi New City Streetcar Project in Nanjing, China. In the experimental results, the streetcar system operation and the progression impacts are shown to affect transit and vehicular traffic. The proposed model presents promising outcomes through the design of streetcar system segmented signal progression, in terms of ensuring high streetcar system efficiency and minimizing negative impacts on transit and vehicular traffic.

  12. Altered B cell receptor signaling in human systemic lupus erythematosus

    Science.gov (United States)

    Jenks, Scott A.; Sanz, Iñaki

    2009-01-01

    Regulation of B cell receptor signaling is essential for the development of specific immunity while retaining tolerance to self. Systemic lupus erythematosus (SLE) is characterized by a loss of B cell tolerance and the production of anti-self antibodies. Accompanying this break down in tolerance are alterations in B cell receptor signal transduction including elevated induced calcium responses and increased protein phosphorylation. Specific pathways that negatively regulate B cell signaling have been shown to be impaired in some SLE patients. These patients have reduced levels of the kinase Lyn in lipid raft microdomains and this reduction is inversely correlated with increased CD45 in lipid rafts. Function and expression of the inhibitory immunoglobulin receptor FcγRIIB is also reduced in Lupus IgM- CD27+ memory cells. Because the relative contribution of different memory and transitional B cell subsets can be abnormal in SLE patients, we believe studies targeted to well defined B cell subsets will be necessary to further our understanding of signaling abnormalities in SLE. Intracellular flow cytometric analysis of signaling is a useful approach to accomplish this goal. PMID:18723129

  13. THE RESTRICTIVELY PRECONDITIONED CONJUGATE GRADIENT METHODS ON NORMAL RESIDUAL FOR BLOCK TWO-BY-TWO LINEAR SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    Junfeng Yin; Zhongzhi Bai

    2008-01-01

    The restrictively preconditioned conjugate gradient (RPCG) method is further developed to solve large sparse system of linear equations of a block two-by-two structure.The basic idea of this new approach is that we apply the RPCG method to the normal-residual equation of the block two-by-two linear system and construct each required approximate matrix by making use of the incomplete orthogonal factorization of the involved matrix blocks.Numerical experiments show that the new method,called the restrictively preconditioned conjugate gradient on normal residual (RPCGNR),is more robust and effective than either the known RPCG method or the standard conjugate gradient on normal residual (CGNR) method when being used for solving the large sparse saddle point problems.

  14. Dissecting Nck/Dock Signaling Pathways in Drosophila Visual System

    Directory of Open Access Journals (Sweden)

    2005-04-01

    Full Text Available The establishment of neuronal connections during embryonic development requires the precise guidance and targeting of the neuronal growth cone, an expanded cellular structure at the leading tip of a growing axon. The growth cone contains sophisticated signaling systems that allow the rapid communication between guidance receptors and the actin cytoskeleton in generating directed motility. Previous studies demonstrated a specific role for the Nck/Dock SH2/SH3 adapter protein in photoreceptor (R cell axon guidance and target recognition in the Drosophila visual system, suggesting strongly that Nck/Dock is one of the long-sought missing links between cell surface receptors and the actin cytoskeleton. In this review, I discuss the recent progress on dissecting the Nck/Dock signaling pathways in R-cell growth cones. These studies have identified additional key components of the Nck/Dock signaling pathways for linking the receptor signaling to the remodeling of the actin cytoskeleton in controlling growth-cone motility.

  15. Signaling mechanisms regulating myelination in the central nervous system

    Institute of Scientific and Technical Information of China (English)

    Jared T.Ahrendsen; Wendy Macklin

    2013-01-01

    The precise and coordinated production of myelin is essential for proper development and function of the nervous system.Diseases that disrupt myelin,including multiple sclerosis,cause significant functional disability.Current treatment aims to reduce the inflammatory component of the disease,thereby preventing damage resulting from demyelination.However,therapies are not yet available to improve natural repair processes after damage has already occurred.A thorough understanding of the signaling mechanisms that regulate myelin generation will improve our ability to enhance repair.In this review,we summarize the positive and negative regulators of myelination,focusing primarily on central nervous system myelination.Axon-derived signals,extracellular signals from both diffusible factors and the extracellular matrix,and intracellular signaling pathways within myelinating oligodendrocytes are discussed.Much is known about the positive regulators that drive myelination,while less is known about the negative regulators that shift active myelination to myelin maintenance at the appropriate time.Therefore,we also provide new data on potential negative regulators of CNS myelination.

  16. Verification of Mixed-Signal Systems with Affine Arithmetic Assertions

    Directory of Open Access Journals (Sweden)

    Carna Radojicic

    2013-01-01

    Full Text Available Embedded systems include an increasing share of analog/mixed-signal components that are tightly interwoven with functionality of digital HW/SW systems. A challenge for verification is that even small deviations in analog components can lead to significant changes in system properties. In this paper we propose the combination of range-based, semisymbolic simulation with assertion checking. We show that this approach combines advantages, but as well some limitations, of multirun simulations with formal techniques. The efficiency of the proposed method is demonstrated by several examples.

  17. Environment-induced self-assembly in phase separated block copolymer systems: A SANS investigation

    International Nuclear Information System (INIS)

    In this research, we examine the effect of non-selective solvent on the large-scale mesoscopic ordering in asymmetric block copolymers, poly(styrene-block-ethylene/butylene-block-styrene) (SEBS) using small angle neutron scattering technique (SANS). SANS measurements were carried out over a wide range of concentrations and temperatures. Evolution of the self-assembled phase morphology in such polymer with the thermodynamic selectivity of solvent, temperature and concentration has been discussed. Correlation between morphology and thermorheological behavior of the gels has also been established

  18. Hepatic venous outflow block in a young patient with Systemic Lupus Erythematosus

    Directory of Open Access Journals (Sweden)

    Ali Ghavidel

    2015-08-01

    Full Text Available Introduction: Hepatic venous outflow block or Budd-Chiari syndrome is a severe liver disease with a 3 years survival rate of 50%. Several conditions have been implicated as a cause of Budd-Chiari syndrome, including myeloproliferative disorders, paroxysmal nocturnal hemoglobinuria, the presence of lupus anti-coagulant, oral contraceptives, pregnancy, and others. In a small number of cases, Budd-Chiari syndrome is associated with the presence of lupus anticoagulant. Anticardiolipin antibodies (ACA are similar to lupus anti-coagulant antiphospholipid antibodies (APLAs, which have been described in patients with recurrent arterial and venous thrombosis, thrombocytopenia, fetal loss, or miscarriage. Case Report: A 23-year-old woman is reported with Budd-Chiari syndrome in whom lupus anticoagulant and anticardiolipin antibodies were shown; 9 months after diagnosis of systemic lupus erythematosus (SLE treatment with steroids admitted with gastrointestinal problems, abdominal pain and ascites and treated oral anticoagulants induced a considerable improvement. This treatment was continued after 1 year, but interruption was followed by redevelopment of ascites. Further treatment with anticoagulants was continued for 5 years with noticeable improvement. Conclusion: Patients with Budd-Chiari syndrome should be tested for lupus anticoagulants and anticardiolipin antibodies, Budd-Chiari syndrome resulting from this cause may have a good response to treatment with oral anticoagulants; this treatment should be maintained permanently, and pregnancy in such patients may initiate serious difficulties. The condition of the patient at follow-up was good.

  19. Novel layered two-dimensional semiconductors as the building blocks for nano-electronic/photonic systems

    Science.gov (United States)

    Su, Guoxiong; De, Debtanu; Hadjiev, Viktor G.; Peng, Haibing

    2014-06-01

    Layered two-dimensional (2D) semiconductors beyond graphene have been emerging as potential building blocks for the next-generation electronic/photonic applications. Representative metal chalcogenides, including the widely studied MoS2, possess similar layered crystal structures with weak interaction between adjacent layers, thus allowing the formation of stable thin-layer crystals with thickness down to a few or even single atomic layer. Other important chalcogenides, involving earth-abundant and environment-friendly materials desirable for sustainable applications, include SnS2 (band gap: 2.1 eV) and SnS (band gap: 1.1 eV). So far, commonly adopted for research purpose are mechanical and liquid exfoliation methods for creating thin layers of such 2D semiconductors. Most recently, chemical vapor deposition (CVD) was attracting significant attention as a practical method for producing thin films or crystal grains of MoS2. However, critical yet still absent is an effective experimental approach for controlling the positions of thin crystal grains of layered 2D semiconductors during the CVD process. Here we report the controlled CVD synthesis of thin crystal arrays of representative layered semiconductors (including SnS2 and SnS) at designed locations on chip, promising large-scale optoelectronic applications. Our work opens a window for future practical applications of layered 2D semiconductors in integrated nano-electronic/photonic systems.

  20. Curing kinetics and morphology of a nanovesicular epoxy/stearyl-block-poly(ethylene oxide) surfactant system.

    Science.gov (United States)

    Bogaerts, K; Lavrenova, A; Spoelstra, A B; Boyard, N; Goderis, B

    2015-08-21

    Brittle epoxy based thermosets can be made tougher by introducing structural inhomogeneities at the micro- or nanoscale. In that respect, nano vesicles and worm-like micelles from self-assembling blockcopolymers have been shown to be very effective. This paper describes the curing kinetics and morphology of an epoxy composed of diglycidyl ether of bisphenol A (DGEBA) and 4,4'-methylenedianiline (MDA), modified by 20% of the surfactant stearyl-block-poly(ethylene oxide). Time resolved, synchrotron small-angle X-ray scattering demonstrates that at any time during the epoxy curing process, the surfactant predominantly adopts a bilayer vesicular nano-morphology. Transmission electron microscopy on fully cured systems reveals the coexistence of spherical and worm-like micelles. Differential scanning calorimetry experiments prove that the presence of surfactant reduces the epoxy curing rate but that ultimately full curing is accomplished. The material glass transition temperature falls below that of the pure resin due to plasticization. It is suggested that favorable secondary interactions between the PEO segments and the epoxy resin are responsible for the observed phenomena. PMID:26144526

  1. Snore related signals processing in a private cloud computing system.

    Science.gov (United States)

    Qian, Kun; Guo, Jian; Xu, Huijie; Zhu, Zhaomeng; Zhang, Gongxuan

    2014-09-01

    Snore related signals (SRS) have been demonstrated to carry important information about the obstruction site and degree in the upper airway of Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) patients in recent years. To make this acoustic signal analysis method more accurate and robust, big SRS data processing is inevitable. As an emerging concept and technology, cloud computing has motivated numerous researchers and engineers to exploit applications both in academic and industry field, which could have an ability to implement a huge blue print in biomedical engineering. Considering the security and transferring requirement of biomedical data, we designed a system based on private cloud computing to process SRS. Then we set the comparable experiments of processing a 5-hour audio recording of an OSAHS patient by a personal computer, a server and a private cloud computing system to demonstrate the efficiency of the infrastructure we proposed.

  2. Protective Effects of Blocking Renin-Angiotensin System on the Progression of Renal Injury in Glomerulosclerosis

    Institute of Scientific and Technical Information of China (English)

    Zequan Ji; Cuiwen Huang; Chengjie Liang; Bo Chen; Shengqiang Chen; Weiwen Sun

    2005-01-01

    To investigate the protective effects of blocking rennin-angiotensin system (RAS) on the progression of renal injury in glomerulosclerosis, a glomerulosclerosis model was made for SD rats by unilateral nephrectomy and being injected with Adriamycin into caudal vein. The rats with glomerulosclerosis were randomly divided as ten pergroup into those without further treatment (group D) and those treated with Benazepril (group DB), Losartan (group DL), or sham-operation (group C), respectively. After 6 weeks of administration of Benazepril or Losartan,the mRNA expressions of TGF-β1, Col Ⅳ, Fn, ET-1 and iNOS in renal cortex were measured by RT-PCR. Besides,the expressions of TGF-β1, ET-1 and iNOS at protein level were detected by Western blotting and the concentrations of Col Ⅳ and Fn were analyzed with immunohistochemistry respectively. Results showed that the rats in group D appeared as obvious proteinuria, hypoalbuminemia and hypercholesterolemia, which had a significant difference compared with group C (p<0.05), and most of their mesangiums were detected with cellular proliferation and significant increasing for extracellular matrix. Renal cortex TGF-β1, Col Ⅳ, Fn, ET-1 and iNOS in rats of group D were increased by 3.59, 2.57, 2.21, 2.58 and 3.28 times at mRNA level, and by 2.60, 1.40, 0.75, 1.83 and 2.15 times at protein level, respectively, compared with group C. When the animals were treated with Benazepril (group DB) or Losartan (group DL), however, the biochemical and pathological damages were significantly recovered, and protein expressions of TGF-β, Col Ⅳ, Fn, ET-1 and iNOS were also significantly diminished (p<0.05). This study suggested that blocking RAS using Benazepril or Losartan can have protective effects on the renal injury in glomerulosclerosis by down-regulating the expressions of TGF-β1, Col Ⅳ, Fn, ET-1 and iNOS. Cellular & Molecular Immunology. 2005;2(2):150-154.

  3. Protective Effects of Blocking Renin-Angiotensin System on the Progression of Renal Injury in Glomerulosclerosis

    Institute of Scientific and Technical Information of China (English)

    ZequanJi; CuiwenHuang; ChengjieLiang; BoChen; ShengqiangChen; WeiwenSun

    2005-01-01

    To investigate the protective effects of blocking rennin-angiotensin system (RAS) on the progression of renal injury in glomerulosclerosis, a glomerulosclerosis model was made for SD rats by unilateral nephrectomy and being injected with Adriamycin into caudal vein. The rats with glomerulosclerosis were randomly divided as ten per group into those without further treatment (group D) and those treated with Benazepril (group DB), Losartan (group DL), or sham-operation (group C), respectively. After 6 weeks of administration of Benazepril or Losartan, the mRNA expressions of TGF-β1, Col IV, Fn, ET-1 and iNOS in renal cortex were measured by RT-PCR. Besides, the expressions of TGF-β1, ET-1 and iNOS at protein level were detected by Western blotting and the concentrations of Col IV and Fn were analyzed with immunohistochemistry respectively. Results showed that the rats in group D appeared as obvious proteinuria, hypoalbuminemia and hypercholesterolemia, which had a significant difference compared with group C (p < 0.05), and most of their mesangiums were detected with cellular proliferation and significant increasing for extracellular matrix. Renal cortex TGF-β1, Col IV, Fn, ET-1 and iNOS in rats of group D were increased by 3.59, 2.57, 2.21, 2.58 and 3.28 times at mRNA level, and by 2.60, 1.40, 0.75, 1.83 and 2.15 times at protein level, respectively, compared with group C. When the animals were treated with Benazepril (group DB) or Losartan (group DL), however, the biochemical and pathological damages were significantly recovered, and protein expressions of TGF-β1, Col IV, Fn, ET-1 and iNOS were also significantly diminished (p < 0.05). This study suggested that blocking RAS using Benazepril or Losartan can have protective effects on the renal injury in glomerulosclerosis by down-regulating the expressions of TGF-β1, Col IV, Fn, ET-1 and iNOS. Cellular & Molecular Immunology. 2005;2(2):150-154.

  4. Calcium efflux systems in stress signalling and adaptation in plants

    Directory of Open Access Journals (Sweden)

    Jayakumar eBose

    2011-12-01

    Full Text Available Transient cytosolic calcium ([Ca2+]cyt elevation is an ubiquitous denominator of the signalling network when plants are exposed to literally every known abiotic and biotic stress. These stress-induced [Ca2+]cyt elevations vary in magnitude, frequency and shape, depending on the severity of the stress as well the type of stress experienced. This creates a unique stress-specific calcium signature that is then decoded by signal transduction networks. While most published papers have been focused predominantly on the role of Ca2+ influx mechanisms in shaping [Ca2+]cyt signatures, restoration of the basal [Ca2+]cyt levels is impossible without both cytosolic Ca2+ buffering and efficient Ca2+ efflux mechanisms removing excess Ca2+ from cytosol, to reload Ca2+ stores and to terminate Ca2+ signalling. This is the topic of the current review. The molecular identity of two major types of Ca2+ efflux systems, Ca2+-ATPase pumps and Ca2+/H+ exchangers, is described, and their regulatory modes are analysed in detail. The spatial and temporal organisation of calcium signalling networks is described, and the importance of existence of intracellular calcium microdomains is discussed. Experimental evidence for the role of Ca2+ efflux systems in plant responses to a range of abiotic and biotic factors is summarised. Contribution of Ca2+-ATPase pumps and Ca2+/H+ exchangers in shaping [Ca2+]cyt signatures is then modelled by using a four-component model (plasma- and endo- membrane-based Ca2+-permeable channels and efflux systems taking into account the cytosolic Ca2+ buffering. It is concluded that physiologically relevant variations in the activity of Ca2+-ATPase pumps and Ca2+/H+ exchangers are sufficient to fully describe all the reported experimental evidence and determine the shape of [Ca2+]cyt signatures in response to environmental stimuli, emphasising the crucial role these active efflux systems play in plant adaptive responses to environment.

  5. Audio Signal Generator System Based On State Machines

    Institute of Scientific and Technical Information of China (English)

    王维喜

    2009-01-01

    A state machine can make program designing quicker, simpler and more efficient. This paper describes in detail the model for a state machine and the idea for its designing and gives the design process of the state machine through an example of audio signal generator system based on Labview. The result shows that the introduction of the state machine can make complex design processes more clear and the revision of programs easier.

  6. Advanced biofeedback from surface electromyography signals using fuzzy system

    DEFF Research Database (Denmark)

    Samani, Afshin; Holtermann, Andreas; Søgaard, Karen;

    2010-01-01

    The aims of this study were to develop a fuzzy inference-based biofeedback system and investigate its effects when inducing active (shoulder elevation) and passive (relax) pauses on the trapezius muscle electromyographic (EMG) activity during computer work. Surface EMG signals were recorded from......-uniform muscle activity changes in the trapezius muscle depicted by increase and decrease of permuted sample entropy in ascending and clavicular parts of trapezius, respectively (P EMG increased approximately 5% in descending part...

  7. System Measures Errors Between Time-Code Signals

    Science.gov (United States)

    Cree, David; Venkatesh, C. N.

    1993-01-01

    System measures timing errors between signals produced by three asynchronous time-code generators. Errors between 1-second clock pulses resolved to 2 microseconds. Basic principle of computation of timing errors as follows: central processing unit in microcontroller constantly monitors time data received from time-code generators for changes in 1-second time-code intervals. In response to any such change, microprocessor buffers count of 16-bit internal timer.

  8. Performance evaluation of block-diagonal preconditioners for the divergence-conforming B-spline discretization of the Stokes system

    KAUST Repository

    Côrtes, A.M.A.

    2015-02-20

    The recently introduced divergence-conforming B-spline discretizations allow the construction of smooth discrete velocity–pressure pairs for viscous incompressible flows that are at the same time inf-sup stable and pointwise divergence-free. When applied to discretized Stokes equations, these spaces generate a symmetric and indefinite saddle-point linear system. Krylov subspace methods are usually the most efficient procedures to solve such systems. One of such methods, for symmetric systems, is the Minimum Residual Method (MINRES). However, the efficiency and robustness of Krylov subspace methods is closely tied to appropriate preconditioning strategies. For the discrete Stokes system, in particular, block-diagonal strategies provide efficient preconditioners. In this article, we compare the performance of block-diagonal preconditioners for several block choices. We verify how the eigenvalue clustering promoted by the preconditioning strategies affects MINRES convergence. We also compare the number of iterations and wall-clock timings. We conclude that among the building blocks we tested, the strategy with relaxed inner conjugate gradients preconditioned with incomplete Cholesky provided the best results.

  9. CXCL12 Signaling in the Development of the Nervous System

    Science.gov (United States)

    Mithal, Divakar S.; Banisadr, Ghazal; Miller, Richard J.

    2015-01-01

    Chemokines are small, secreted proteins that have been shown to be important regulators of leukocyte trafficking and inflammation. All the known effects of chemokines are transduced by action at a family of G protein coupled receptors. Two of these receptors, CCR5 and CXCR4, are also known to be the major cellular receptors for HIV-1. Consideration of the evolution of the chemokine family has demonstrated that the chemokine Stromal cell Derived Factor-1 or SDF1 (CXCL12) and its receptor CXCR4 are the most ancient members of the family and existed in animals prior to the development of a sophisticated immune system. Thus, it appears that the original function of chemokine signaling was in the regulation of stem cell trafficking and development. CXCR4 signaling is important in the development of many tissues including the nervous system. Here we discuss the manner in which CXCR4 signaling can regulate the development of different structures in the central and peripheral nervous systems and the different strategies employed to achieve these effects. PMID:22270883

  10. A novel 300 kW arc plasma inverter system based on hierarchical controlled building block structure

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    To date, the high power arc plasma technology is widely used. A next generation high power arc plasma system based on building block structure is presented. The whole arc plasma inverter system is composed of 12 paralleled units to increase the system output capability. The hierarchical control system is adopted to improve the reliability and flexibility of the high power arc plasma inverter. To ensure the reliable turn on and off of the IGBT module in each building block unit, a special pulse drive circuit is designed by using pulse transformer. The experimental result indicates that the high power arc plasma inverter system can transfer 300 kW arc plasma energy reliably with high efficiency.

  11. Power and signal transmission for mobile teleoperated systems

    International Nuclear Information System (INIS)

    Appropriate means must be furnished for supplying power and for sending controlling commands to mobile teleoperated systems. Because a sizable number of possibilities are available for such applications, methods used in designing both the power and communications systems built into mobile vehicles that serve in radiological emergencies must be carefully selected. This paper describes a number of umbilical, on-board, and wireless systems used in tranmitting power that are available for mobile teleoperator services. The pros and cons of selecting appropriate methods from a list of possible communication systems (wired, fiber optic, and radio frequency) are also examined. Moreover, hybrid systems combining wireless power transmissions with command-information signals are also possible

  12. Positioning models and systems based on digital television broadcasting signals

    Institute of Scientific and Technical Information of China (English)

    HE Feng; WU Lenan

    2007-01-01

    The requirement and feasibility of the positioning system using digital television(DTV)broadcasting signals are analyzed.The principle of DTV positioning on the basis of frame synchronization is brought forward and the ranging characteristic is studied that the observables are asynchronously measured during the same epoch interval.The models of the pseudo-range observation and Doppler carrier phase integral are researched.The system observation and state equations are presented on the basis of the above models.The simulation results showed that DTV positioning technology could remarkably improve the precision of system state estimates using smoothing methods for positioning systems or integrated navigation systems.The DTV positioning that has a sub-meter level ranging error and meter level positioning accuracy can parallel with and even taken as a beneficial substitute for the tradition positioning technology.

  13. Systemic mifepristone blocks reconsolidation of cue-conditioned fear; propranolol prevents this effect.

    Science.gov (United States)

    Pitman, Roger K; Milad, Mohammed R; Igoe, Sarah A; Vangel, Mark G; Orr, Scott P; Tsareva, Alina; Gamache, Karine; Nader, Karim

    2011-08-01

    Reducing reconsolidation of reactivated traumatic memories may offer a novel pharmacological treatment for posttraumatic stress disorder (PTSD). Preclinical research is needed to identify candidate drugs. We evaluated the ability of postreactivation mifepristone (RU38486, a glucocorticoid antagonist), alone and in combination with propranolol (a beta-adrenergic blocker), both given systemically, to reduce cue-conditioned fear in rats. On Day 1, a 30-s tone conditioned stimulus (CS) was paired with an electric shock unconditioned stimulus (US). On Day 2, the CS was presented without the US (reactivation), and the freezing conditioned response (CR) was measured. This was immediately followed by subcutaneous injection of vehicle, mifepristone 30 mg/kg, propranolol 10 mg/kg, or both. On Day 3, the CR was again measured as a test of postreactivation long-term memory (PR-LTM). On Day 10, the CR was again measured to evaluate spontaneous recovery. On Day 11, the US was presented alone (reinstatement). On Day 12, the CR was again measured. A fifth group received mifepristone without the CS presentation (nonreactivation) on Day 2. A sixth group was tested four hours after the Day 2 mifepristone injection to measure postreactivation short-term memory. Postreactivation, but not nonreactivation, mifepristone produced a decrement in the CR that did not undergo spontaneous recovery and underwent only modest reinstatement. Mifepristone did not exert its effect when administered concurrently with propranolol. Postreactivation mifepristone did not impair short-term memory. Systemic mifepristone blocks the reconsolidation of cue-conditioned fear in rats. Concurrent administration of propranolol prevents this effect. Postreactivation mifepristone may be a promising treatment for PTSD, but not necessarily in combination with propranolol. PMID:21688892

  14. Design principles of paradoxical signaling in the immune system

    Science.gov (United States)

    Hart, Yuval

    A widespread feature of cell-cell signaling systems is paradoxical pleiotropy: the same secreted signaling molecule can induce opposite effects in the responding cells. For example, the cytokine IL-2 can promote proliferation and death of T-cells. The role of such paradoxical signaling remains unclear. We suggest that this mechanism provides homeostatic concentration of cells, independent of initial conditions. The crux of the paradoxical mechanism is the combination of a positive and a negative feedback loops creating two stable states - an OFF state and an ON state. Experimentally, we found that CD4 + cells grown in culture with a 30-fold difference in initial concentrations reached a homeostatic concentration nearly independent of initial cell levels (ON-state). Below an initial threshold, cell density decayed to extinction (OFF-state). Mathematical modeling explained the observed cell and cytokine dynamics and predicted conditions that shifted cell fate from homeostasis to the OFF-state. We suggest that paradoxical signaling provides cell circuits with specific dynamical features that are robust to environmental perturbations.

  15. Estimation of uncertainty of impedance function of SSI system based on existing comprehensive block-shaking test data

    International Nuclear Information System (INIS)

    Study on advanced seismic design for LWR has been carried out by the Nuclear Power Engineering Corporation (NUPEC), under the sponsorship of the Ministry of International Trade and Industry (MTTI) of Japan. Considerable number of soil-structure interaction (SSI) tests shaking large concrete block (block-shaking tests) have been carried out in various places in Japan to obtain soil-structure interaction data. The researchers compared their test results with analytical results in their papers. They have reached various conclusions reflecting their own test results. So, it is necessary to gather the data altogether and to have common knowledge as to the uncertainty between tests and analyses. This paper evaluates the uncertainty of impedance functions of SSI system based on the comprehensive existing block-shaking data. It also estimates the uncertainty of responses of reactor buildings due to the uncertainty of impedance functions

  16. BlockSolve95 users manual: Scalable library software for the parallel solution of sparse linear systems

    Energy Technology Data Exchange (ETDEWEB)

    Jones, M.T.; Plassmann, P.E.

    1995-12-01

    BlockSolve95 is a software library for solving large, sparse systems of linear equations on massively parallel computers or networks of workstations. The matrices must be symmetric in structure; however, the matrix nonzero values may be either symmetric or nonsymmetric. The nonzeros must be real valued. BlockSolve95 uses a message-passing paradigm and achieves portability through the use of the MPI message-passing standard. Emphasis has been placed on achieving both good professor performance through the use of higher-level BLAS and scalability through the use of advanced algorithms. This report gives detailed instructions on the use of BlockSolve95 and descriptions of a number of program examples that can be used as templates for application programs.

  17. Signal Processing System for the CASA Integrated Project I Radars

    Energy Technology Data Exchange (ETDEWEB)

    Bharadwaj, Nitin; Chandrasekar, V.; Junyent, Francesc

    2010-09-01

    This paper describes the waveform design space and signal processing system for dual-polarization Doppler weather radar operating at X band. The performance of the waveforms is presented with ground clutter suppression capability and mitigation of range velocity ambiguity. The operational waveform is designed based on operational requirements and system/hardware requirements. A dual Pulse Repetition Frequency (PRF) waveform was developed and implemented for the first generation X-band radars deployed by the Center for Collaborative Adaptive Sensing of the Atmosphere (CASA). This paper presents an evaluation of the performance of the waveforms based on simulations and data collected by the first-generation CASA radars during operations.

  18. Photonics for microwave systems and ultra-wideband signal processing

    Science.gov (United States)

    Ng, W.

    2016-08-01

    The advantages of using the broadband and low-loss distribution attributes of photonics to enhance the signal processing and sensing capabilities of microwave systems are well known. In this paper, we review the progress made in the topical areas of true-time-delay beamsteering, photonic-assisted analog-to-digital conversion, RF-photonic filtering and link performances. We also provide an outlook on the emerging field of integrated microwave photonics (MWP) that promise to reduce the cost of MWP subsystems and components, while providing significantly improved form-factors for system insertion.

  19. Calibration of Frequency Data Collection Systems Using Shortwave Radio Signals

    Science.gov (United States)

    Estler, Ron

    2000-09-01

    The atomic-clock-derived audio tones broadcast on the National Institute of Standards and Technology (NIST) shortwave station WWV are used to calibrate computer frequency data collection systems via Fast Fourier Transforms (FFT). Once calibrated, the data collection system can be used to accurately determine the audio signals used in several instructional physical chemistry laboratory experiments. This method can be applied to virtually any hardware-software configuration that allows adjustment of the apparent time scale (digitizing rate) of the recorded audio file.

  20. Dangerous mating systems: signal complexity, signal content and neural capacity in spiders.

    Science.gov (United States)

    Herberstein, M E; Wignall, A E; Hebets, E A; Schneider, J M

    2014-10-01

    Spiders are highly efficient predators in possession of exquisite sensory capacities for ambushing prey, combined with machinery for launching rapid and determined attacks. As a consequence, any sexually motivated approach carries a risk of ending up as prey rather than as a mate. Sexual selection has shaped courtship to effectively communicate the presence, identity, motivation and/or quality of potential mates, which help ameliorate these risks. Spiders communicate this information via several sensory channels, including mechanical (e.g. vibrational), visual and/or chemical, with examples of multimodal signalling beginning to emerge in the literature. The diverse environments that spiders inhabit have further shaped courtship content and form. While our understanding of spider neurobiology remains in its infancy, recent studies are highlighting the unique and considerable capacities of spiders to process and respond to complex sexual signals. As a result, the dangerous mating systems of spiders are providing important insights into how ecology shapes the evolution of communication systems, with future work offering the potential to link this complex communication with its neural processes. PMID:25088579

  1. Blocking protein phosphatase 2A signaling prevents endothelial-to-mesenchymal transition and renal fibrosis: a peptide-based drug therapy

    Science.gov (United States)

    Deng, Yuanjun; Guo, Yanyan; Liu, Ping; Zeng, Rui; Ning, Yong; Pei, Guangchang; Li, Yueqiang; Chen, Meixue; Guo, Shuiming; Li, Xiaoqing; Han, Min; Xu, Gang

    2016-01-01

    Endothelial-to-mesenchymal transition (EndMT) contributes to the emergence of fibroblasts and plays a significant role in renal interstitial fibrosis. Protein phosphatase 2A (PP2A) is a major serine/threonine protein phosphatase in eukaryotic cells and regulates many signaling pathways. However, the significance of PP2A in EndMT is poorly understood. In present study, the role of PP2A in EndMT was evaluated. We demonstrated that PP2A activated in endothelial cells (EC) during their EndMT phenotype acquisition and in the mouse model of obstructive nephropathy (i.e., UUO). Inhibition of PP2A activity by its specific inhibitor prevented EC undergoing EndMT. Importantly, PP2A activation was dependent on tyrosine nitration at 127 in the catalytic subunit of PP2A (PP2Ac). Our renal-protective strategy was to block tyrosine127 nitration to inhibit PP2A activation by using a mimic peptide derived from PP2Ac conjugating a cell penetrating peptide (CPP: TAT), termed TAT-Y127WT. Pretreatment withTAT-Y127WT was able to prevent TGF-β1-induced EndMT. Administration of the peptide to UUO mice significantly ameliorated renal EndMT level, with preserved density of peritubular capillaries and reduction in extracellular matrix deposition. Taken together, these results suggest that inhibiting PP2Ac nitration using a mimic peptide is a potential preventive strategy for EndMT in renal fibrosis.

  2. Activation of Robo1 signaling of breast cancer cells by Slit2 from stromal fibroblast restrains tumorigenesis via blocking PI3K/Akt/β-catenin pathway.

    Science.gov (United States)

    Chang, Po-Hao; Hwang-Verslues, Wendy W; Chang, Yi-Cheng; Chen, Chun-Chin; Hsiao, Michael; Jeng, Yung-Ming; Chang, King-Jen; Lee, Eva Y-H P; Shew, Jin-Yuh; Lee, Wen-Hwa

    2012-09-15

    Tumor microenvironment plays a critical role in regulating tumor progression by secreting factors that mediate cancer cell growth. Stromal fibroblasts can promote tumor growth through paracrine factors; however, restraint of malignant carcinoma progression by the microenvironment also has been observed. The mechanisms that underlie this paradox remain unknown. Here, we report that the tumorigenic potential of breast cancer cells is determined by an interaction between the Robo1 receptor and its ligand Slit2, which is secreted by stromal fibroblasts. The presence of an active Slit2/Robo1 signal blocks the translocation of β-catenin into nucleus, leading to downregulation of c-myc and cyclin D1 via the phosphoinositide 3-kinase (PI3K)/Akt pathway. Clinically, high Robo1 expression in the breast cancer cells correlates with increased survival in patients with breast cancer, and low Slit2 expression in the stromal fibroblasts is associated with lymph node metastasis. Together, our findings explain how a specific tumor microenvironment can restrain a given type of cancer cell from progression and show that both stromal fibroblasts and tumor cell heterogeneity affect breast cancer outcomes.

  3. Noise helped manifestation of intrinsic frequency: A case study in the mesoscopic hormone signaling system

    Institute of Scientific and Technical Information of China (English)

    Lin Ji; Yuanyuan Zhang; Xiufeng Lang; Wenxiang Hu; Qianshu Li

    2009-01-01

    The selective sustainment of nonlinear systems to signals is of great significance to signal transduction in living systems. We take hormone signaling as an example, and investigate the sustainment of internal and external signals. Simulation results prove that signals with "intrinsic frequency", no matter if it is noise induced or external injected, can be selectively sustained by exploiting internal and/or external noise. Both the internal and external noise can optimize the noise-induced signals, and the optimization is rather robust to the disturbance of external signals with other frequencies. These results are of significance for weak signal detection and trausduction in the presence of external signals.

  4. The signal connections in robot integrated manufacturing systems

    Directory of Open Access Journals (Sweden)

    D. Reclik

    2008-01-01

    Full Text Available Purpose: The main goal of this paper is that, the robot integrated manufacturing systems are more popular and useful in the industry. Moreover, the communication in those systems might be realized by many different data exchange solutions. Using this kind of solution causes the data exchange incompatibility. This paper deals with different ways in informatics connection of all of the components in robot integrated manufacturing system.Design/methodology/approach: Incompatibility is a result of usage many different communication systems between components in lathe center. The way of mutual signal connections were the target of researches.Findings: As a result of scientific work, the universal and compatible informatics connection system of the robot lathe center was created.Research limitations/implications: The project of the data exchange system is confined to PROFIBUS DP lan.Practical implications: The result of the researches was developing a technical element choice procedure of the data exchange depending on transport means quantity and system composition in the robot lathe system.Originality/value: This is a brand new paper, which describes internal systems of data exchange in robot integrated manufacturing system in example of automatic lathe center.

  5. Altered signaling in systemic juvenile idiopathic arthritis monocytes.

    Science.gov (United States)

    Macaubas, Claudia; Wong, Elizabeth; Zhang, Yujuan; Nguyen, Khoa D; Lee, Justin; Milojevic, Diana; Shenoi, Susan; Stevens, Anne M; Ilowite, Norman; Saper, Vivian; Lee, Tzielan; Mellins, Elizabeth D

    2016-02-01

    Systemic juvenile idiopathic arthritis (sJIA) is characterized by systemic inflammation and arthritis. Monocytes are implicated in sJIA pathogenesis, but their role in disease is unclear. The response of sJIA monocytes to IFN may be dysregulated. We examined intracellular signaling in response to IFN type I (IFNα) and type II (IFNγ) in monocytes during sJIA activity and quiescence, in 2 patient groups. Independent of disease activity, monocytes from Group 1 (collected between 2002 and 2009) showed defective STAT1 phosphorylation downstream of IFNs, and expressed higher transcript levels of SOCS1, an inhibitor of IFN signaling. In the Group 2 (collected between 2011 and 2014), monocytes of patients with recent disease onset were IFNγ hyporesponsive, but in treated, quiescent subjects, monocytes were hyperresponsive to IFNγ. Recent changes in medication in sJIA may alter the IFN hyporesponsiveness. Impaired IFN/pSTAT1 signaling is consistent with skewing of sJIA monocytes away from an M1 phenotype and may contribute to disease pathology.

  6. A Miniaturized System for Neural Signal Acquiring and Processing

    Institute of Scientific and Technical Information of China (English)

    WANG Min; GAO Guang-hong; XIANG Dong-sheng; CAO Mao-yong; JIA Ai-bin; DING Lei; KONG Hui-min

    2008-01-01

    To collect neural activity data from awake, behaving freely animals, we develop miniaturized implantable recording system by the modern chip:Programmable System on Chip(PSoC) and through chronic electrodes in the cortex. With PSoC family member CY8C29466,the system completed operational and instrument amplifiers, filters, timers, AD convertors, and serial communication, etc. The signal processing was dealt with virtual instrument technology. All of these factors can significantly affect the price and development cycle of the project. The result showed that the system was able to record and analyze neural extrocellular discharge generated by neurons continuously for a week or more. This is very useful for the interdisciplinary research of neuroscience and information engineering technique.The circuits and architecture of the devices can be adapted for neurobiology and research with other small animals.

  7. Chemosensory signals and their receptors in the olfactory neural system.

    Science.gov (United States)

    Ihara, S; Yoshikawa, K; Touhara, K

    2013-12-19

    Chemical communication is widely used among various organisms to obtain essential information from their environment required for life. Although a large variety of molecules have been shown to act as chemical cues, the molecular and neural basis underlying the behaviors elicited by these molecules has been revealed for only a limited number of molecules. Here, we review the current knowledge regarding the signaling molecules whose flow from receptor to specific behavior has been characterized. Discussing the molecules utilized by mice, insects, and the worm, we focus on how each organism has optimized its reception system to suit its living style. We also highlight how the production of these signaling molecules is regulated, an area in which considerable progress has been recently made.

  8. Population Blocks.

    Science.gov (United States)

    Smith, Martin H.

    1992-01-01

    Describes an educational game called "Population Blocks" that is designed to illustrate the concept of exponential growth of the human population and some potential effects of overpopulation. The game material consists of wooden blocks; 18 blocks are painted green (representing land), 7 are painted blue (representing water); and the remaining…

  9. FireSignal-Data acquisition and control system software

    Energy Technology Data Exchange (ETDEWEB)

    Neto, A. [Associacao Euratom/IST, Centro de Fusao Nuclear, Av. Rovisco Pais, P-1049-001 Lisboa (Portugal)], E-mail: andre.neto@cfn.ist.utl.pt; Fernandes, H.; Duarte, A.; Carvalho, B.B.; Sousa, J.; Valcarcel, D.F. [Associacao Euratom/IST, Centro de Fusao Nuclear, Av. Rovisco Pais, P-1049-001 Lisboa (Portugal); Hron, M. [Asociace EURATOM IPP.CR, Prague (Czech Republic); Varandas, C.A.F. [Associacao Euratom/IST, Centro de Fusao Nuclear, Av. Rovisco Pais, P-1049-001 Lisboa (Portugal)

    2007-10-15

    Control of fusion experiments requires non-ambiguous, easy to use, user-interfaces to configure hardware devices. With that aim, a highly generic system for data control and acquisition has been developed. Among the main features it allows remote hardware configuration, shot launching, data sharing between connected users and experiment monitoring. The system is fully distributed: the hardware driver nodes, clients and servers are completely independent from each other and might run in different operating systems and programmed in different languages. All the communication is provided through the Common Object Request Broker Architecture (CORBA) protocol. FireSignal is designed to be as independent as possible from any kind of constraints as it is a plugin based system. Database, data viewers and the security system are some examples of what can easily be changed and adapted to the target machine's needs. In this system, every hardware is described in eXtensible Markup Language (XML) and with this information Graphical User Interfaces (GUI) are automatically built and user's parameter configuration validated. Any type of hardware device can be integrated in the system as long as it is described in XML and the respective driver developed. Any modern programming language can be used to develop these drivers. Currently Python and Java generic drivers are used. Data storage and indexing is time stamp event-based. Nodes are responsible for tagging the acquired samples with the absolute time stamps and to react to machine events. FireSignal is currently being used to control the ISTTOK/PT and CASTOR/CZ tokamaks.

  10. Cervical sympathetic block regulates early systemic inflammatory response in severe trauma patients

    OpenAIRE

    Liu, Ming-Hua; Tian, Jun; Su, Yong-Ping; WANG, Tao; Xiang, Qiang; Wen, Liang

    2013-01-01

    Background This aim of this study was to investigate the effects of one-side cervical sympathetic block on early inflammatory response in severe trauma patients. Material/Methods Thirty severe trauma patients with injury severity score (ISS) of 16 to 25 were randomly divided into treatment and control groups (n=15 each). Patients in the treatment group underwent a right-side stellate ganglion block (SGB) using 8 mL 0.75% ropivacaine for 4 times, with the first injection within 12 hr of admiss...

  11. 2012 Proceedings of the International Conference on Communications, Signal Processing, and Systems

    CERN Document Server

    Wang, Wei; Mu, Jiasong; Liang, Jing; Zhang, Baoju; Pi, Yiming; Zhao, Chenglin

    2012-01-01

    Communications, Signal Processing, and Systems is a collection of contributions coming out of the International Conference on Communications, Signal Processing, and Systems (CSPS) held October 2012. This book provides the state-of-art developments of Communications, Signal Processing, and Systems, and their interactions in multidisciplinary fields, such as Smart Grid. The book also examines Radar Systems, Sensor Networks, Radar Signal Processing, Design and Implementation of Signal Processing Systems and Applications. Written by experts and students in the fields of Communications, Signal Processing, and Systems.

  12. Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling.

    Science.gov (United States)

    Feldmann, Georg; Mishra, Anjali; Hong, Seung-Mo; Bisht, Savita; Strock, Christopher J; Ball, Douglas W; Goggins, Michael; Maitra, Anirban; Nelkin, Barry D

    2010-06-01

    Cyclin-dependent kinase 5 (CDK5), a neuronal kinase that functions in migration, has been found to be activated in some human cancers in which it has been implicated in promoting metastasis. In this study, we investigated the role of CDK5 in pancreatic cancers in which metastatic disease is most common at diagnosis. CDK5 was widely active in pancreatic cancer cells. Functional ablation significantly inhibited invasion, migration, and anchorage-independent growth in vitro, and orthotopic tumor formation and systemic metastases in vivo. CDK5 blockade resulted in the profound inhibition of Ras signaling through its critical effectors RalA and RalB. Conversely, restoring Ral function rescued the effects of CDK5 inhibition in pancreatic cancer cells. Our findings identify CDK5 as a pharmacologically tractable target to degrade Ras signaling in pancreatic cancer.

  13. Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression via suppression of Ras-Ral signaling

    Science.gov (United States)

    Feldmann, Georg; Mishra, Anjali; Hong, Seung-Mo; Bisht, Savita; Strock, Christopher J.; Ball, Douglas W.; Goggins, Michael; Maitra, Anirban; Nelkin, Barry D.

    2011-01-01

    Cyclin-dependent kinase 5 (CDK5), a neuronal kinase that functions in migration, has been found to be activated in some human cancers where it has been implicated in promoting metastasis. In this study, we investigated the role of CDK5 in pancreatic cancers where metastatic disease is most common at diagnosis. CDK5 was widely active in pancreatic cancer cells. Functional ablation significantly inhibited invasion, migration and anchorage-independent growth in vitro, and orthotopic tumor formation and systemic metastases in vivo. CDK5 blockade resulted in profound inhibition of Ras signaling through its critical effectors RalA and RalB. Conversely, restoring Ral function rescued the effects of CDK5 inhibition in pancreatic cancer cells. Our findings identify CDK5 as a pharmacologically tractable target to degrade Ras signaling in pancreatic cancer. PMID:20484029

  14. Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems

    CERN Document Server

    Thiriet, Marc

    2013-01-01

    The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors.  Activation of...

  15. Effects of HVDC on power systems small signal angle stability

    Energy Technology Data Exchange (ETDEWEB)

    Custodio, D.T.; Paccini, R.O.; Kopcak, I.; Costa, V.F. da [State University of Campinas (UNICAMP), SP (Brazil). School of Electrical and Computer Engineering. Power Systems Dept.], Emails: totti@dsee.fee.unicamp.br, rodrigo@dsee.fee.unicamp.br, kopcak@dsee.fee.unicamp.br, vivaldo@dsee.fee.unicamp.br

    2009-07-01

    In this paper, a didactic method for parameters tuning of the Power Oscillation Damper (POD) coupled to the HVDC constant current controller is proposed utilizing the MATLAB package with a control system toolbox. First, modal analysis is done from the system state matrix to determine the critical mode and oscillation natural frequency. Input and output linearized matrixes are built to single-input and single-output (SISO) control systems. The phase to be compensated between the active power flow in the parallel AC inter-tie and the current reference signal of the HVDC constant current controller is obtained from the Nyquist theorem. Following, the POD time constants are obtained. Finally, the static gain of the POD is tuned based on the root locus method of the classical control theory. Simulations results prove that the DC power modulation is efficient to damp the AC power oscillations. This method is straightforward because only involves matrix operation. (author)

  16. Energy Signal Tool for Decision Support in Building Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Henze, G. P.; Pavlak, G. S.; Florita, A. R.; Dodier, R. H.; Hirsch, A. I.

    2014-12-01

    A prototype energy signal tool is demonstrated for operational whole-building and system-level energy use evaluation. The purpose of the tool is to give a summary of building energy use which allows a building operator to quickly distinguish normal and abnormal energy use. Toward that end, energy use status is displayed as a traffic light, which is a visual metaphor for energy use that is either substantially different from expected (red and yellow lights) or approximately the same as expected (green light). Which light to display for a given energy end use is determined by comparing expected to actual energy use. As expected, energy use is necessarily uncertain; we cannot choose the appropriate light with certainty. Instead, the energy signal tool chooses the light by minimizing the expected cost of displaying the wrong light. The expected energy use is represented by a probability distribution. Energy use is modeled by a low-order lumped parameter model. Uncertainty in energy use is quantified by a Monte Carlo exploration of the influence of model parameters on energy use. Distributions over model parameters are updated over time via Bayes' theorem. The simulation study was devised to assess whole-building energy signal accuracy in the presence of uncertainty and faults at the submetered level, which may lead to tradeoffs at the whole-building level that are not detectable without submetering.

  17. Chemotaxis signaling systems in model beneficial plant-bacteria associations.

    Science.gov (United States)

    Scharf, Birgit E; Hynes, Michael F; Alexandre, Gladys M

    2016-04-01

    Beneficial plant-microbe associations play critical roles in plant health. Bacterial chemotaxis provides a competitive advantage to motile flagellated bacteria in colonization of plant root surfaces, which is a prerequisite for the establishment of beneficial associations. Chemotaxis signaling enables motile soil bacteria to sense and respond to gradients of chemical compounds released by plant roots. This process allows bacteria to actively swim towards plant roots and is thus critical for competitive root surface colonization. The complete genome sequences of several plant-associated bacterial species indicate the presence of multiple chemotaxis systems and a large number of chemoreceptors. Further, most soil bacteria are motile and capable of chemotaxis, and chemotaxis-encoding genes are enriched in the bacteria found in the rhizosphere compared to the bulk soil. This review compares the architecture and diversity of chemotaxis signaling systems in model beneficial plant-associated bacteria and discusses their relevance to the rhizosphere lifestyle. While it is unclear how controlling chemotaxis via multiple parallel chemotaxis systems provides a competitive advantage to certain bacterial species, the presence of a larger number of chemoreceptors is likely to contribute to the ability of motile bacteria to survive in the soil and to compete for root surface colonization.

  18. Modeling a verification test system for mixed-signals circuits

    NARCIS (Netherlands)

    San Segundo Bello, David; Tangelder, Ronald; Kerkhoff, Hans

    2001-01-01

    In contrast to the large number of logic gates and storage circuits encountered in digital networks, purely analog networks usually have relatively few circuit primitives (operational amplifiers and so on). The complexity lies not in the number of building blocks but in the complexity of each block

  19. Signal and reference wave dually encrypted digital holographic system

    Institute of Scientific and Technical Information of China (English)

    ZHU YiChao; ZHANG JiaSen; GONG QiHuang

    2008-01-01

    We propose a secure digital holographic system with signal and reference waves dually encrypted. Two random phase masks are used to encrypt the images in the input and the Fourier planes. The reference beam is phase encoded by another random phase mask. The encrypted image and the key are recorded by a CCD camera. The data can be processed or transferred directly by computer. We theoretically and experimentally demonstrate encryption and decryption of multiple images and the results show a high quality and good fault tolerance.

  20. Fault Tolerant Neural Network for ECG Signal Classification Systems

    Directory of Open Access Journals (Sweden)

    MERAH, M.

    2011-08-01

    Full Text Available The aim of this paper is to apply a new robust hardware Artificial Neural Network (ANN for ECG classification systems. This ANN includes a penalization criterion which makes the performances in terms of robustness. Specifically, in this method, the ANN weights are normalized using the auto-prune method. Simulations performed on the MIT ? BIH ECG signals, have shown that significant robustness improvements are obtained regarding potential hardware artificial neuron failures. Moreover, we show that the proposed design achieves better generalization performances, compared to the standard back-propagation algorithm.

  1. Analysis of the blocking behaviour of schema transformations in relational database systems

    NARCIS (Netherlands)

    Wevers, Lesley; Hofstra, Matthijs; Tammens, Menno; Huisman, Marieke; Keulen, van Maurice

    2015-01-01

    In earlier work we have extended the TPC-C benchmark with basic and complex schema transformations. This paper uses this benchmark to investigate the blocking behaviour of online schema transformations in PostgreSQL, MySQL and Oracle 11g. First we discuss experiments using the data definition langua

  2. Structural analysis of superposed fault systems of the Bornholm horst block, Tornquist Zone, Denmark

    DEFF Research Database (Denmark)

    Graversen, Ole

    2009-01-01

    The Bornholm horst block is composed of Precambrian crystalline basement overlain by Palaeozoicand Mesozoic cover rocks. The cover intervals are separated by an angular unconformity and a hiatus spanning the Devonian through Middle Triassic interval. Late Palaeozoic faulting of the Early Palaeozoic...

  3. Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis.

    Directory of Open Access Journals (Sweden)

    Wenle Xia

    Full Text Available Photo-activation of psoralen with UVA irradiation, referred to as PUVA, is used in the treatment of proliferative skin disorders. The anti-proliferative effects of PUVA have been largely attributed to psoralen intercalation of DNA, which upon UV treatment, triggers the formation of interstrand DNA crosslinks (ICL that inhibit transcription and DNA replication. Here, we show that PUVA exerts antitumor effects in models of human breast cancer that overexpress the ErbB2 receptor tyrosine kinase oncogene, through a new mechanism. Independent of ICL formation, the antitumor effects of PUVA in ErbB2+ breast cancer models can instead be mediated through inhibition of ErbB2 activation and signaling. Using a mass spectroscopy-based approach, we show for the first time that photo-activated 8MOP (8-methoxypsoralen interacts with the ErbB2 catalytic autokinase domain. Furthermore, PUVA can reverse therapeutic resistance to lapatinib and other ErbB2 targeted therapies, including resistance mediated via expression of a phosphorylated, truncated form of ErbB2 (p85(ErbB2 that is preferentially expressed in tumor cell nuclei. Current ErbB2 targeted therapies, small molecule kinase inhibitors or antibodies, do not block the phosphorylated, activated state of p85(ErbB2. Here we show that PUVA reduced p85(ErbB2 phosphorylation leading to tumor cell apoptosis. Thus, in addition to its effects on DNA and the formation of ICL, PUVA represents a novel ErbB2 targeted therapy for the treatment of ErbB2+ breast cancers, including those that have developed resistance to other ErbB2 targeted therapies.

  4. The Bucket System – A computer mediated signaling system for group improvisation

    DEFF Research Database (Denmark)

    Dahlstedt, Palle; Nilsson, Per Anders; Robair, Gino

    2015-01-01

    The Bucket System is a new system for computer-mediated ensemble improvisation, designed by improvisers for improvisers. Coming from a tradition of structured free ensemble improvisation practices (comprovisation), influenced by post-WW2 experimental music practices, it is a signaling system...

  5. BIG DATA-DRIVEN FAST REDUCING THE VISUAL BLOCK ARTIFACTS OF DCT COMPRESSED IMAGES FOR URBAN SURVEILLANCE SYSTEMS

    Directory of Open Access Journals (Sweden)

    Ling Hu

    2016-07-01

    Full Text Available The Urban Surveillance Systems generate huge amount of video and image data and impose high pressure onto the recording disks. It is obvious that the research of video is a key point of big data research areas. Since videos are composed of images, the degree and efficiency of image compression are of great importance. Although the DCT based JPEG standard are widely used, it encounters insurmountable problems. For instance, image encoding deficiencies such as block artifacts have to be removed frequently. In this paper, we propose a new, simple but effective method to fast reduce the visual block artifacts of DCT compressed images for urban surveillance systems. The simulation results demonstrate that our proposed method achieves better quality than widely used filters while consuming much less computer CPU resources.

  6. Fluorescence-enhancement with different ionic inputs in a cryptand-based multi-receptor signalling system

    Indian Academy of Sciences (India)

    Bamaprasad Bag; Parimal K Bharadwaj

    2005-03-01

    Two molecules of a laterally non-symmetric aza cryptand have been attached to 9,10-dimethylanthracene to obtain a multi-receptor fluorescent signalling system in the ``receptor-spacer-fluorophore- spacer-receptor” format. In the absence of a metal ion, weak fluorescence is observed upon excitation of the anthryl group owing to efficient photo-induced electron transfer (PET) of the lone pair of N attached to the anthryl group. However, when a metal salt is added, the lone pair is engaged, thus in blocking of the PET and leading to recovery of fluorescence to different extents depending upon the nature of the metal ion.

  7. Method for analyzing signaling networks in complex cellular systems.

    Science.gov (United States)

    Plavec, Ivan; Sirenko, Oksana; Privat, Sylvie; Wang, Yuker; Dajee, Maya; Melrose, Jennifer; Nakao, Brian; Hytopoulos, Evangelos; Berg, Ellen L; Butcher, Eugene C

    2004-02-01

    Now that the human genome has been sequenced, the challenge of assigning function to human genes has become acute. Existing approaches using microarrays or proteomics frequently generate very large volumes of data not directly related to biological function, making interpretation difficult. Here, we describe a technique for integrative systems biology in which: (i) primary cells are cultured under biologically meaningful conditions; (ii) a limited number of biologically meaningful readouts are measured; and (iii) the results obtained under several different conditions are combined for analysis. Studies of human endothelial cells overexpressing different signaling molecules under multiple inflammatory conditions show that this system can capture a remarkable range of functions by a relatively small number of simple measurements. In particular, measurement of seven different protein levels by ELISA under four different conditions is capable of reconstructing pathway associations of 25 different proteins representing four known signaling pathways, implicating additional participants in the NF-kappaBorRAS/mitogen-activated protein kinase pathways and defining additional interactions between these pathways. PMID:14745015

  8. Improper Gaussian Signaling in Interference-Limited Systems

    KAUST Repository

    Gaafar, Mohamed

    2016-05-01

    In the last decade, wireless applications have witnessed a tremendous growth. This can be envisioned in the surge of smart devices which became almost in everyone\\'s possession, demand for high speed connection and the internet of things (IoT) along with its enabling technologies. Hence, the multiuser interference became the main limiting factor in wireless communications. Moreover, just like diamonds and emeralds, the electromagnetic spectrum is limited and precious. Therefore, the high data rate application may not be satisfied by our current technologies. In order to solve this spectrum scarcity problem, researchers have steered their focus to develop new techniques such as cognitive radio (CR) and in-band full-duplex (FD). However, these systems suffer from the interference problem that can dramatically impede their quality-of-service (QoS). Therefore, investigating communication techniques/systems that can relieve the interference adverse signature becomes imperative. Improper Gaussian signaling (IGS) has been recently shown to outperform the traditional proper Gaussian signaling (PGS) in several interference-limited systems. In this thesis, we use IGS in order to mitigate the interference issue in three different communication settings. IGS has the ability to control the interference signal dimension, and hence, it can be considered as one form of interference alignment. In the first part, we investigate an underlay CR system with in-band FD primary users (PUs) and one-way communication for the secondary user (SU). IGS is employed to alleviate the interference introduced by the SU on the PUs. First, we derive a closed form expression and an upper bound for the SU and PUs outage probabilities, respectively. Second, we optimize the SU signal parameters, represented in its power and the circularity coefficient, to achieve the design objectives of the SU while satisfying certain QoS constraints for the PU under instantaneous, average and partial channel state

  9. Special Issue on Signal Processing for Mechanical Systems in Honor of Professor Simon Braun

    Science.gov (United States)

    Fassois, Spilios D.

    2016-06-01

    This Special Issue is in honor of a pioneer of the area of Signal Processing for Mechanical Systems and, at the same time, Founding Editor of the Journal of Mechanical Systems and Signal Processing (MSSP), Professor Simon Braun.

  10. Metabolite transport and associated sugar signalling systems underpinning source/sink interactions.

    Science.gov (United States)

    Griffiths, Cara A; Paul, Matthew J; Foyer, Christine H

    2016-10-01

    Metabolite transport between organelles, cells and source and sink tissues not only enables pathway co-ordination but it also facilitates whole plant communication, particularly in the transmission of information concerning resource availability. Carbon assimilation is co-ordinated with nitrogen assimilation to ensure that the building blocks of biomass production, amino acids and carbon skeletons, are available at the required amounts and stoichiometry, with associated transport processes making certain that these essential resources are transported from their sites of synthesis to those of utilisation. Of the many possible posttranslational mechanisms that might participate in efficient co-ordination of metabolism and transport only reversible thiol-disulphide exchange mechanisms have been described in detail. Sucrose and trehalose metabolism are intertwined in the signalling hub that ensures appropriate resource allocation to drive growth and development under optimal and stress conditions, with trehalose-6-phosphate acting as an important signal for sucrose availability. The formidable suite of plant metabolite transporters provides enormous flexibility and adaptability in inter-pathway coordination and source-sink interactions. Focussing on the carbon metabolism network, we highlight the functions of different transporter families, and the important of thioredoxins in the metabolic dialogue between source and sink tissues. In addition, we address how these systems can be tailored for crop improvement. PMID:27487250

  11. Block Advertisement Protocol

    OpenAIRE

    Nemirovsky, Danil

    2015-01-01

    Bitcoin, a decentralized cryptocurrency, has attracted a lot of attention from academia, financial service industry and enthusiasts. The trade-off between transaction confirmation throughput and centralization of hash power do not allow Bitcoin to perform at the same level as modern payment systems. Block Advertisement Protocol is proposed as a step to resolve this issue. The protocol allows block mining and block relaying to happen in parallel. The protocol dictates a miner to advertise the ...

  12. The Role Played by Blocking Systems over Europe in Abnormal Weather over Kingdom of Saudi Arabia in Summer 2010

    Directory of Open Access Journals (Sweden)

    Y. Y. Hafez

    2013-01-01

    Full Text Available The present paper investigates the role played by blocking high systems over Europe in abnormal weather over the Kingdom of Saudi Arabia (KSA in summer 2010. The NCEP/NCAR Reanalysis data of several meteorological elements such as surface air temperature, wind, sea level pressure, relative humidity, outgoing long wave radiation, precipitation rate, and geopotential height at level 500 hpa for summer seasons for the period 1948–2012 and in particular of summer 2010 have been used and analyzed through the present work. Furthermore, the corresponding daily and monthly mean values of climatic indices NAO index, SOI, and El-Nino3.4 have been analyzed. The results uncovered that air current in the upper atmosphere over Europe and NAO, SOI and El-Nino3.4 have impacts on the weather conditions over KSA through the study period 1948–2012. During the period of persistence of blocking system over Europe in summer 2010, results revealed that; weather in KSA was fully controlled by two abnormal weather regimes. The first one is the European blocking system and negative anomaly of NAO from the north. The second one is the positive anomaly of SOI and negative anomaly of El-Nino3.4.

  13. Light relations and performance of signal grass in silvopastoral system

    Directory of Open Access Journals (Sweden)

    Cynara Oliveira Diniz Rodrigues

    2014-03-01

    Full Text Available The aim was to evaluate the influence of different spatial arrangements of trees [(3×2×20 m, (2×2×9 m and 2×9 m] and sampling sites (center of row spacing and side of tree rows with regard to the amount and quality of light in the understory of silvopastoral systems and their effects on the production and chemical composition of pasture. The experimental design was a randomized block in a split plot, with three replications. The sampling site affected absolute irradiance, photosynthetic active radiation (PAR, light interception (LI and red/far red ratio, with higher rates in the center of spacing. There were high and positive correlations between LI/leaf area index (LAI, LI/dry mater (DM and LAI/DM in the center and LI/LAI and FAR/DM in the side of tree rows. Spatial arrangement (3×2×20 m had higher rates for plant height (PH, DM and neutral detergent fiber rate, while (2×2×9 m had high leaf/stem ratio and crude protein rate. In the case of the sampling site, higher rates of PH and DM were reported in the center. Forage composition was not affected by sampling sites. Highest production of DM was obtained in the (3×2×20 m arrangement and improvements in forage composition were observed in denser arrangements.

  14. Quantifying process heterogeneity: Signal propagation in hydrological systems

    Science.gov (United States)

    Lischeid, G.; Merz, C.; Schindler, U.; Schulz, R.; Steidl, J.; Tauschke, R.

    2009-04-01

    Natural hydrological systems are characterized by heterogeneous structures. The typical length scale of the relevant structures is smaller than the resolution of area-covering methods that are available at the catchment-scale. On the other hand these structures are too large to be treated as random effects and are often related to hydrological behaviour in a non-linear way. Consequently, model results, risk assessments etc. are prone to substantial uncertainties. This is often addressed by random realizations of the structures based on given probability density functions and geostatistical properties, and then analysing the resulting effects on hydrological behaviour, e.g., discharge or groundwater table fluctuations, using process-based models. In this study an alternative approach was followed. Hydrological systems usually act as low-pass filters: An input signal (precipitation, groundwater recharge, tracer application, etc.) is damped and delayed during its passage through the system. This study aimed at characterizing the damping behaviour in a quantitative way. Large perturbations usually are transmitted at much higher velocities compared to small perturbations, thus hindering a spectrum analysis based approach. Instead, time series of soil water content, groundwater level and catchment runoff from the Uckermark region in North Germany were analysed using a principal component analysis. In all cases, the first component depicted the mean behaviour, and the second component explained a large fraction of the deviations from the mean behaviour. The loadings of the first two components could be used as an index of the mean damping behaviour for the given time period. Results of the soil water content data showed a linear increase of damping with depth at most sites. However, different sites differed substantially even for backfilled lysimeters that were considered to be homogeneous. There was no clear relationship between clay content and damping behaviour. The

  15. HLA Class I and II Blocks Are Associated to Susceptibility, Clinical Subtypes and Autoantibodies in Mexican Systemic Sclerosis (SSc Patients.

    Directory of Open Access Journals (Sweden)

    Tatiana S Rodriguez-Reyna

    Full Text Available Human leukocyte antigen (HLA polymorphism studies in Systemic Sclerosis (SSc have yielded variable results. These studies need to consider the genetic admixture of the studied population. Here we used our previously reported definition of genetic admixture of Mexicans using HLA class I and II DNA blocks to map genetic susceptibility to develop SSc and its complications.We included 159 patients from a cohort of Mexican Mestizo SSc patients. We performed clinical evaluation, obtained SSc-associated antibodies, and determined HLA class I and class II alleles using sequence-based, high-resolution techniques to evaluate the contribution of these genes to SSc susceptibility, their correlation with the clinical and autoantibody profile and the prevalence of Amerindian, Caucasian and African alleles, blocks and haplotypes in this population.Our study revealed that class I block HLA-C*12:03-B*18:01 was important to map susceptibility to diffuse cutaneous (dc SSc, HLA-C*07:01-B*08:01 block to map the susceptibility role of HLA-B*08:01 to develop SSc, and the C*07:02-B*39:05 and C*07:02-B*39:06 blocks to map the protective role of C*07:02 in SSc. We also confirmed previous associations of HLA-DRB1*11:04 and -DRB1*01 to susceptibility to develop SSc. Importantly, we mapped the protective role of DQB1*03:01 using three Amerindian blocks. We also found a significant association for the presence of anti-Topoisomerase I antibody with HLA-DQB1*04:02, present in an Amerindian block (DRB1*08:02-DQB1*04:02, and we found several alleles associated to internal organ damage. The admixture estimations revealed a lower proportion of the Amerindian genetic component among SSc patients.This is the first report of the diversity of HLA class I and II alleles and haplotypes Mexican patients with SSc. Our findings suggest that HLA class I and class II genes contribute to the protection and susceptibility to develop SSc and its different clinical presentations as well as

  16. A solution for applying IEC 61499 function blocks in the development of substation automation systems

    OpenAIRE

    Vlad, Valentin; Popa, Cezar D.; Turcu, Corneliu O.; Buzduga, Corneliu

    2015-01-01

    This paper presents a solution for applying IEC 61499 function blocks along with IEC 61850 specifications in modeling and implementing control applications for substations automation. The IEC 61499 artifacts are used for structuring the control logic, while the IEC 61850 concepts for communication and information exchange between the automation devices. The proposed control architecture was implemented and validated in a simple fault protection scenario with simulated power equipment.

  17. Unlocking Chain Exchange in Highly Amphiphilic Block Polymer Micellar Systems: Influence of Agitation

    OpenAIRE

    Murphy, Ryan P.; Kelley, Elizabeth G.; Rogers, Simon A.; Sullivan, Millicent O.; Epps, Thomas H.

    2014-01-01

    Chain exchange between block polymer micelles in highly selective solvents, such as water, is well-known to be arrested under quiescent conditions, yet this work demonstrates that simple agitation methods can induce rapid chain exchange in these solvents. Aqueous solutions containing either pure poly(butadiene-b-ethylene oxide) or pure poly(butadiene-b-ethylene oxide-d 4) micelles were combined and then subjected to agitation by vortex mixing, concentric cylinder Couette flow, or nitrogen gas...

  18. Hepatic venous outflow block in a young patient with Systemic Lupus Erythematosus

    OpenAIRE

    Ali Ghavidel

    2015-01-01

    Introduction: Hepatic venous outflow block or Budd-Chiari syndrome is a severe liver disease with a 3 years survival rate of 50%. Several conditions have been implicated as a cause of Budd-Chiari syndrome, including myeloproliferative disorders, paroxysmal nocturnal hemoglobinuria, the presence of lupus anti-coagulant, oral contraceptives, pregnancy, and others. In a small number of cases, Budd-Chiari syndrome is associated with the presence of lupus anticoagulant. Anticardiolipin antibodies ...

  19. Begging the Signalling Question: Quantum Signalling and the Dynamics of Multiparticle Systems

    OpenAIRE

    Peacock, Kent A.; Hepburn, Brian S.

    1999-01-01

    Many authors state that quantum nonlocality could not involve any controllable superluminal transmission of momentum-energy, signals, or information. We claim that most or all no-signalling proofs to date are question-begging, in that they depend upon assumptions about the locality of the measurement process that needed to be established in the first place. We analyse no-signalling arguments by Bohm and Hiley, and Shimony, which illustrate the problem in an especially striking way.

  20. Begging the Signalling Question Quantum Signalling and the Dynamics of Multiparticle Systems

    CERN Document Server

    Peacock, K A; Peacock, Kent A.; Hepburn, Brian S.

    1999-01-01

    Many authors state that quantum nonlocality could not involve any controllable superluminal transmission of momentum-energy, signals, or information. We claim that most or all no-signalling proofs to date are question-begging, in that they depend upon assumptions about the locality of the measurement process that needed to be established in the first place. We analyse no-signalling arguments by Bohm and Hiley, and Shimony, which illustrate the problem in an especially striking way.

  1. Adaptive Noise Cancellation Method Used for Wheel Speed Signal of Integrate ABS/ASR System

    Institute of Scientific and Technical Information of China (English)

    MA Yue-feng; LIU Zhao-du; QI Zhi-quan; CUI Hai-feng

    2006-01-01

    A novel adaptive noise cancellation method for wheel speed signal of the anti-lock braking system/anti-slip regulation(ABS/ASR) control system is proposed. Based on the spectrum distribution of vehicle's wheel speed signal got from fast Fourier transform under various conditions, the high-pass filter is used to deal with original wheel speed signals sampled to get reference noise signal and the original wheel speed signals are used as adaptive filter's desired outputs. The difference between original signals and reference noise signals is used as the error signal for the adaptive FIR filter and also used as the whole adaptive noise cancellation system's final output. This method can obtain the noise signal on-line and is easy to use for real control system,which is useful to improve the performance of integrate system ABS/ASR.

  2. Permutation-based Homogeneous Block Content Authentication for Watermarking

    Directory of Open Access Journals (Sweden)

    S.Maruthuperumal

    2013-02-01

    Full Text Available In modern days, digital watermarking has become an admired technique for hitting data in digital images to help guard against copyright infringement. The proposed Permutation-based Homogeneous Block Content authentication (PHBC methods develop a secure and excellence strong watermarking algorithm that combines the reward of permutation-based Homogeneous block (PHB with that of significant and insignificant bit values with X0R encryption function using Max coefficient of least coordinate value for embedding the watermark. In the projected system uses the relationship between the permutation blocks to embed many data into Homogeneous blocks without causing solemn distortion to the watermarked image. The experimental results show that the projected system is very efficient in achieving perceptual invisibility with an increase in the Peak Signal to Noise Ratio (PSNR. Moreover, the projected system is robust to a variety of signal processing operations, such as image Cropping, Rotation, Resizing, Adding noise, Filtering , Blurring and Motion blurring.

  3. Characteristic parameters of electromagnetic signals from a human heart system

    Institute of Scientific and Technical Information of China (English)

    Liu Xin-Yuan; Pei Liu-Qing; Wang Yin; Zhang Su-Ming; Gao Hong-Lei; Dai Yuan-Dong

    2011-01-01

    The electromagnetic field of a human heart system is a bioelectromagnetic field. Electrocardiography (ECG)and magnetocardiography (MCG)are both carriers of electromagnetic information about the cardiac system, and they are nonstationary signals. In this study, ECG and MCG data from healthy subjects are acquired;the MCG data are captured using a high-T, radio frequency superconducting quantum interference device (HTc rf SQUIDs)and the QRS complexes in these data are analysed by the evolutionary spectrum analysis method. The results show that the quality factor Q and the central frequency fz of the QRS complex evolutionary spectrum are the characteristic parameters (CHPs)of ECG and MCG in the time-frequency domain. The confidence intervals of the mean values of the CHPs are estimated by the Student t distribution method in mathematical statistics. We believe that there are threshold ranges of the mean values of Q and fz for healthy subjects. We have postulated the following criterion:if the mean values of CHPs are in the proper ranges, the cardiac system is in a normal condition and it possesses the capability of homeostasis. In contrast, if the mean values of the CHPs do not lie in the proper ranges, the homeostasis of the cardiac system is lacking and some cardiac disease may follow. The results and procedure of MCG CHPs in the study afford a technological route for the application of HTc rf SQUIDs in cardiology.

  4. Characteristic parameters of electromagnetic signals from a human heart system

    Science.gov (United States)

    Liu, Xin-Yuan; Pei, Liu-Qing; Wang, Yin; Zhang, Su-Ming; Gao, Hong-Lei; Dai, Yuan-Dong

    2011-04-01

    The electromagnetic field of a human heart system is a bioelectromagnetic field. Electrocardiography (ECG) and magnetocardiography (MCG) are both carriers of electromagnetic information about the cardiac system, and they are nonstationary signals. In this study, ECG and MCG data from healthy subjects are acquired; the MCG data are captured using a high-Tc radio frequency superconducting quantum interference device (HTc rf SQUIDs) and the QRS complexes in these data are analysed by the evolutionary spectrum analysis method. The results show that the quality factor Q and the central frequency fz of the QRS complex evolutionary spectrum are the characteristic parameters (CHPs) of ECG and MCG in the time—frequency domain. The confidence intervals of the mean values of the CHPs are estimated by the Student t distribution method in mathematical statistics. We believe that there are threshold ranges of the mean values of Q and fz for healthy subjects. We have postulated the following criterion: if the mean values of CHPs are in the proper ranges, the cardiac system is in a normal condition and it possesses the capability of homeostasis. In contrast, if the mean values of the CHPs do not lie in the proper ranges, the homeostasis of the cardiac system is lacking and some cardiac disease may follow. The results and procedure of MCG CHPs in the study afford a technological route for the application of HTc rf SQUIDs in cardiology.

  5. Random Telegraph Signal in a Metallic Double-Dot System

    Science.gov (United States)

    Vardi, Yuval; Guttman, Avraham; Bar-Joseph, Israel

    2015-03-01

    Double quantum dot systems offer a unique opportunity for studying the world of quantum transport. This stems from the ability to localize an electron in a limited region in space on the dot, and monitor its presence and properties. Another system, in which electrons can be stored and measured, is an electronic trap in solid. The electrons in such a trap are better isolated from the environment. However, their measurement and control are more difficult. Here we demonstrate how these two systems, metallic double-dots and electronic traps, are combined to yield a hybrid structure in which an electron can be stored for long durations and can be easily detected and measured. We investigate the dynamics of a single electron surface trap, embedded in a self-assembly metallic double-dot system. The charging and discharging of the trap by a single electron is manifested as a random telegraph signal of the current through the double-dot device. We find that we can control the duration that an electron resides in the trap through the current, varying it between fractions of a second to more than an hour, at the Coulomb blockade region. We suggest that the observed switching is the electrical manifestation of the optical blinking phenomenon, commonly observed in semiconductor quantum dots. Y. Vardi, A. Guttman, and I. Bar-Joseph, Nano Lett. 14, 2794 (2014). [DOI: 10.1021/nl500803p

  6. Component/connection/signal modeling of accelerator systems.

    Energy Technology Data Exchange (ETDEWEB)

    Dohan, D. A.; Accelerator Systems Division (APS)

    2006-01-01

    This paper presents a pragmatic global approach to data modeling a complex facility such as a particle accelerator. By successively partitioning the facility into collaborating subsystems, one eventually arrives at the component level--the point at which the subsystem is replaceable as a single unit. The fundamental goal of the model is to capture the dynamical relationships (i. e., the connections) that exist among the accelerator-components. Components participate in one or more of three connection types: control, housing, and power. These connections are captured in a multi-hierarchical model capable of handling any component of the accelerator, from the macro scale (magnets, power supplies, racks, etc.) to the embedded scale (circuit board components), if desired. The connection approach has been used to model the signal flows between the components via their port connections. The result is a schema for a cable database that provides end-to-end signal tracing throughout the facility. The paper will discuss the multi-hierarchy nature of the model and its success in replacing the 'Revision Controlled Drawing' approach to system documentation.

  7. Lesson Thirteen Trifascicular Block

    Institute of Scientific and Technical Information of China (English)

    鲁端; 王劲

    2005-01-01

    @@ A complete trifascicular block would result in complete AV block. The idio ventricular rhythm has a slower rate and a wide QRS complex because the pacemaker is located at the peripheral part of the conduction system distal to the sites of the block1. Such a rhythm may be difficult to differentiate from bifascicular or bundle branch block combined with complete block at a higher level such as the AV node or His bundle2. Besides a slower ventricular rate, a change in the morphology of the QRS complex from a previous known bifascicular pattern would be strongly suggestive of a trifascicular origin of the complete AV block3. A His bundle recording is required for a definitive diagnosis, however.

  8. Simulation of signal transduction in model multiprotein systems

    Science.gov (United States)

    Su, Julius

    2009-03-01

    To simulate the dynamics of multiprotein machines, I have developed a method called multiconformer Brownian dynamics (mcBD). In this method, proteins rotate and translate via Brownian motion while their conformations are varied among a prestored set of structures on a simplified energy landscape, taking into account inter-protein interactions. As an example, I build a simple model of a G-protein coupled receptor/G-protein complex, and show that ligand binding causes conformational shifts, which induce GDP to leave, GTP to bind, and the complex to dissociate. The two proteins couple their fast fluctuations together into large-scale coordinated functional motions, resulting in signal transduction. I vary the shapes, electrostatics, and energy landscapes of the proteins independently and examine the impact this has on the system's function. In one result, increasing the binding between proteins improves the fidelity of communication, but at the expense of overall switching frequency.

  9. Development of DC-TOP Signal Processing System

    Energy Technology Data Exchange (ETDEWEB)

    Nam, Uk Won [Korea Astronomy and Space Science Institute, Daejeon (Korea, Republic of)

    2010-08-15

    The PSD panel of the DC-TOF consists of 32 PSD(Position Sensitive Detector) and its signal processing part. Each signal processing part can communicate with Data Acquisition PC with TCP/IP protocol. By such a way, total 352 PSD(l1 paneD can be used in DC-TOF. In panel, 1 DSP, 8 PML and 64 PAM are installed as signal processing part, and control neutron detecting signal from 32 PSDs

  10. Statistical Signal Processing in Humanitarian Mine Clerance Systems

    OpenAIRE

    Karlsen, Brian; Sørensen, Helge Bjarup Dissing; Larsen, Jan; Jakobsen, Kaj Bjarne

    2002-01-01

    Denne artikel beskriver kortfattet metoder og resultater relateret til clutterreduktion (clutter: uønskede reflekterede signaler) i jordradar- (eng. ground penetrating radar, GPR) signaler vha. statistiske signalbehandlingsmetoder baseret på Independent Component Analysis (ICA). Formålet ved denne form for clutterreduktion er at dekomponere GPR signaler i clutter og clutterreducerede underrum. Ved kun at anvende de clutterreducerede underrum kan man reducere clutter i GPR signaler. Metoderne ...

  11. Signal transduction in cells of the immune system in microgravity

    Directory of Open Access Journals (Sweden)

    Huber Kathrin

    2008-10-01

    Full Text Available Abstract Life on Earth developed in the presence and under the constant influence of gravity. Gravity has been present during the entire evolution, from the first organic molecule to mammals and humans. Modern research revealed clearly that gravity is important, probably indispensable for the function of living systems, from unicellular organisms to men. Thus, gravity research is no more or less a fundamental question about the conditions of life on Earth. Since the first space missions and supported thereafter by a multitude of space and ground-based experiments, it is well known that immune cell function is severely suppressed in microgravity, which renders the cells of the immune system an ideal model organism to investigate the influence of gravity on the cellular and molecular level. Here we review the current knowledge about the question, if and how cellular signal transduction depends on the existence of gravity, with special focus on cells of the immune system. Since immune cell function is fundamental to keep the organism under imnological surveillance during the defence against pathogens, to investigate the effects and possible molecular mechanisms of altered gravity is indispensable for long-term space flights to Earth Moon or Mars. Thus, understanding the impact of gravity on cellular functions on Earth will provide not only important informations about the development of life on Earth, but also for therapeutic and preventive strategies to cope successfully with medical problems during space exploration.

  12. SELF-ADAPTIVE CONTROLS OF A COMPLEX CELLULAR SIGNALING TRANSDUCTION SYSTEM

    Institute of Scientific and Technical Information of China (English)

    LI Hong; ZHOU Zhiyuan; DAI Rongyang; LUO Bo; ZHENG Xiaoli; YANG Wenli; HE Tao; WU Minglu

    2004-01-01

    In cells, the interactions of distinct signaling transduction pathways originating from cross-talkings between signaling molecules give rise to the formation of signaling transduction networks, which contributes to the changes (emergency) of kinetic behaviors of signaling system compared with single molecule or pathway. Depending on the known experimental data, we have constructed a model for complex cellular signaling transduction system, which is derived from signaling transduction of epidermal growth factor receptor in neuron. By the computational simulating methods, the self-adaptive controls of this system have been investigated. We find that this model exhibits a relatively stable selfadaptive system, especially to over-stimulation of agonist, and the amplitude and duration of signaling intermediates in it could be controlled by multiple self-adaptive effects, such as "signal scattering", "positive feedback", "negative feedback" and "B-Raf shunt". Our results provide an approach to understanding the dynamic behaviors of complex biological systems.

  13. Control of intrachain charge transfer in model systems for block copolymer photovoltaic materials.

    Science.gov (United States)

    Johnson, Kerr; Huang, Ya-Shih; Huettner, Sven; Sommer, Michael; Brinkmann, Martin; Mulherin, Rhiannon; Niedzialek, Dorota; Beljonne, David; Clark, Jenny; Huck, Wilhelm T S; Friend, Richard H

    2013-04-01

    We report the electronic properties of the conjugated coupling between a donor polymer and an acceptor segment serving as a model for the coupling in conjugated donor-acceptor block copolymers. These structures allow the study of possible intrachain photoinduced charge separation, in contrast to the interchain separation achieved in conventional donor-acceptor blends. Depending on the nature of the conjugated linkage, we observe varying degrees of modification of the excited states, including the formation of intrachain charge transfer excitons. The polymers comprise a block (typically 18 repeat units) of P3HT, poly(3-hexyl thiophene), coupled to a single unit of F8-TBT (where F8 is dioctylfluorene, and TBT is thiophene-benzothiadiazole-thiophene). When the P3HT chain is linked to the TBT unit, we observe formation of a localized charge transfer state, with red-shifted absorption and emission. Independent of the excitation energy, this state is formed very rapidly (<40 fs) and efficiently. Because there is only a single TBT unit present, there is little scope for long-range charge separation and it is relatively short-lived, <1 ns. In contrast, when the P3HT chain and TBT unit are separated by the wider bandgap F8 unit, there is little indication for modification of either ground or excited electronic states, and longer-lived charge separated states are observed.

  14. Theoretical analysis and simulation of a code division multiple access system (cdma for secure signal transmission in wideband channels

    Directory of Open Access Journals (Sweden)

    Stevan M. Berber

    2014-06-01

    Code Division Multiple Access (CDMA technique which allows communications of multiple users in the same communication system. This is achieved in such a way that each user is assigned a unique code sequence, which is used at the receiver side to discover the information dedicated to that user. These systems belong to the group of communication systems for direct sequence spread spectrum systems. Traditionally, CDMA systems use binary orthogonal spreading codes. In this paper, a mathematical model and simulation of a CDMA system based on the application of non-binary, precisely speaking, chaotic spreading sequences. In their nature, these sequences belong to random sequences with infinite periodicity, and due to that they are appropriate for applications in the systems that provide enhanced security against interception and secrecy in signal transmission. Numerous papers are dedicated to the development of CDMA systems in flat fading channels. This paper presents the results of these systems analysis for the case when frequency selective fading is present in the channel. In addition, the paper investigates a possibility of using interleaving techniques to mitigate fading in a wideband channel with the frequency selective fading. Basic structure of a CDMA communication system and its operation In this paper, a CDMA system block schematic is ppresented and the function of all blocks is explained. Notation  to be used in the paper is introduced. Chaotic sequences are defined and explained in accordance with the method of their generation. A wideband channel with frequency selective fading is defined by its impulse response function. Theoretical analysis of a CDMA system with flat fading in a narrowband channel A narrowband channel and flat fading are defined. A mathematical analysis of the system is conducted by presenting the signal expressions at vital points in the transmitter and receiver. The expression of the signal at the output of the sequence correlator is

  15. Engineering satellite-based navigation and timing global navigation satellite systems, signals, and receivers

    CERN Document Server

    Betz, J

    2016-01-01

    This book describes the design and performance analysis of satnav systems, signals, and receivers. It also provides succinct descriptions and comparisons of all the world’s satnav systems. Its comprehensive and logical structure addresses all satnav signals and systems in operation and being developed. Engineering Satellite-Based Navigation and Timing: Global Navigation Satellite Systems, Signals, and Receivers provides the technical foundation for designing and analyzing satnav signals, systems, and receivers. Its contents and structure address all satnav systems and signals: legacy, modernized, and new. It combines qualitative information with detailed techniques and analyses, providing a comprehensive set of insights and engineering tools for this complex multidisciplinary field. Part I describes system and signal engineering including orbital mechanics and constellation design, signal design principles and underlying considerations, link budgets, qua tifying receiver performance in interference, and e...

  16. An interactive system for seismic signal detection and identification

    International Nuclear Information System (INIS)

    The methods to distinguish an underground explosion from an earthquake are mainly based on exploiting the differences in the source functions of the two processes and locating the depth of source. Various characteristics of seismic signals generated by these sources are usually represented by different parameters or identifiers. However, it is not possible for a single identifier to distinguish an explosion from an earthquake with equal effectiveness in all situations. Usually a combination of several identifiers is found to provide effective means for the identification of seismic sources. In order to use the multiple parameters in an optimum way, an interactive system (IS) for detection and identification of global events has been developed using short period data of Gauribidanur array. This report describes the salient features of the IS and demonstrates its effectiveness in identifying an event using weighted combination of the parameters together with the depth of source. It is intended to augment the system with long period data in the next phase of the development. (author). 37 refs., 14 figs., 2 tabs

  17. Digital Signal Processing Based Real Time Vehicular Detection System

    Institute of Scientific and Technical Information of China (English)

    YANG Zhaoxuan; LIN Tao; LI Xiangping; LIU Chunyi; GAO Jian

    2005-01-01

    Traffic monitoring is of major importance for enforcing traffic management policies.To accomplish this task,the detection of vehicle can be achieved by exploiting image analysis techniques.In this paper,a solution is presented to obtain various traffic parameters through vehicular video detection system(VVDS).VVDS exploits the algorithm based on virtual loops to detect moving vehicle in real time.This algorithm uses the background differencing method,and vehicles can be detected through luminance difference of pixels between background image and current image.Furthermore a novel technology named as spatio-temporal image sequences analysis is applied to background differencing to improve detection accuracy.Then a hardware implementation of a digital signal processing (DSP) based board is described in detail and the board can simultaneously process four-channel video from different cameras. The benefit of usage of DSP is that images of a roadway can be processed at frame rate due to DSP′s high performance.In the end,VVDS is tested on real-world scenes and experiment results show that the system is both fast and robust to the surveillance of transportation.

  18. Analysis on Design of Kohonen-network System Based on Classification of Complex Signals

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The key methods of detection and classification of the electroencephalogram(EEG) used in recent years are introduced . Taking EEG for example, the design plan of Kohonen neural network system based on detection and classification of complex signals is proposed, and both the network design and signal processing are analyzed, including pre-processing of signals, extraction of signal features, classification of signal and network topology, etc.

  19. Zitongxi Block

    Institute of Scientific and Technical Information of China (English)

    1996-01-01

    @@ Zitongxi Block (Western Zitong Block), is located in Zitong County, northwest of Sichuan Province (as shown on Fig. 8 ). Geologically. it is situated in the Zitong Depression, southwest of the middle Longmenshan faulted and folded belt, covering an area of 1 830 km2. Transportation is very convenient. A crisscross network of highways run through the block and the Baocheng railway is nearby. The climate is moderate. Most area belongs to hilly land with the elevation of 500-600 m.The Tongjiang River runs across the area.

  20. A signal processing method for the friction-based endpoint detection system of a CMP process

    Energy Technology Data Exchange (ETDEWEB)

    Xu Chi; Guo Dongming; Jin Zhuji; Kang Renke, E-mail: xuchi_dut@163.com [Key Laboratory for Precision and Non-Traditional Machining Technology of Ministry of Education, Dalian University of Technology, Dalian 116024 (China)

    2010-12-15

    A signal processing method for the friction-based endpoint detection system of a chemical mechanical polishing (CMP) process is presented. The signal process method uses the wavelet threshold denoising method to reduce the noise contained in the measured original signal, extracts the Kalman filter innovation from the denoised signal as the feature signal, and judges the CMP endpoint based on the feature of the Kalman filter innovation sequence during the CMP process. Applying the signal processing method, the endpoint detection experiments of the Cu CMP process were carried out. The results show that the signal processing method can judge the endpoint of the Cu CMP process. (semiconductor technology)

  1. Design Error Performance of Space-Frequency Block Coded OFDM Systems with Different Equalizers and For Different Modulation Schemes

    Directory of Open Access Journals (Sweden)

    Rijhun Tripathi

    2012-01-01

    Full Text Available —Multiple transmit and receive antennas can be used to form multiple-input multiple-output (MIMO channels to increase the capacity (by a factor of the minimum number of transmit and receive antennas and data rate. In this paper, the combination of MIMO technology and orthogonal frequency division multiplexing (OFDM systems is considered for wideband transmission to mitigate inter symbol interference and to enhance system capacity. It owns the advantages of both MIMO and OFDM. MIMO-OFDM system exploits the space and frequency diversity simultaneously to improve the performance of system. The coding is done across OFDM subcarriers rather than OFDM symbols. In this paper, the performance of Space-Frequency (SF block coding for MIMO-OFDM along with different equalizers is investigated. Bit Error Rate (BER analysis is presented using different equalizers and then optimum equalization method is suggested.

  2. Non-Linear Detection for Joint Space-Frequency Block Coding and Spatial Multiplexing in OFDM-MIMO Systems

    DEFF Research Database (Denmark)

    Rahman, Imadur Mohamed; Marchetti, Nicola; Fitzek, Frank;

    2005-01-01

    In this work, we have analyzed a joint spatial diversity and multiplexing transmission structure for MIMO-OFDM system, where Orthogonal Space-Frequency Block Coding (OSFBC) is used across all spatial multiplexing branches. We have derived a BLAST-like non-linear Successive Interference Cancellation...... in this paper. We have found that a linear two-stage receiver for the proposed system [1] performs very close to the non-linear receiver studied in this work. Finally, we compared the system performance in spatially correlated scenario. It is found that higher amount of spatial correlation at the transmitter...... (SIC) receiver where the detection is done on subcarrier by sub-carrier basis based on both Zero Forcing (ZF) and Minimum Mean Square Error (MMSE) nulling criterion for the system. In terms of Frame Error Rate (FER), MMSE based SIC receiver performs better than all other receivers compared...

  3. Expression of the Wnt signaling system in central nervous system axon guidance and regeneration

    Directory of Open Access Journals (Sweden)

    Edmund eHollis

    2012-02-01

    Full Text Available Wnt signaling is essential for axon wiring throughout the development of the nervous system in vertebrates and invertebrates. In vertebrates, Wnts are expressed in gradients that span the entire anterior-posterior axis in the spinal cord and the medial-lateral axis in the superior colliculus. In the brainstem, Wnts are expressed in more complex gradients along the anterior-posterior axis. These gradients provide directional information for axon pathfinding and positional information for topographic mapping and are detected by cell polarity signaling pathways. The gradient expression of Wnts and the coordinated expression of Wnt signaling systems are regulated by mechanisms which are currently unknown. Injury to the adult spinal cord results in the re-induction of Wnts in multiple cell types around the lesion site and their signaling system in injured axons. Reinduced Wnts form gradients around the lesion site, with the lesion site being the peak. The reinduced Wnts may be responsible for the well-known retraction of descending motor axons through the atypical kinase receptor Ryk. Wnt signaling is an appealing therapeutic target for CNS repair. The mechanisms regulating the reinduction will be informative for therapeutic design.

  4. Hardware System for Real-Time EMG Signal Acquisition and Separation Processing during Electrical Stimulation.

    Science.gov (United States)

    Hsueh, Ya-Hsin; Yin, Chieh; Chen, Yan-Hong

    2015-09-01

    The study aimed to develop a real-time electromyography (EMG) signal acquiring and processing device that can acquire signal during electrical stimulation. Since electrical stimulation output can affect EMG signal acquisition, to integrate the two elements into one system, EMG signal transmitting and processing method has to be modified. The whole system was designed in a user-friendly and flexible manner. For EMG signal processing, the system applied Altera Field Programmable Gate Array (FPGA) as the core to instantly process real-time hybrid EMG signal and output the isolated signal in a highly efficient way. The system used the power spectral density to evaluate the accuracy of signal processing, and the cross correlation showed that the delay of real-time processing was only 250 μs. PMID:26210898

  5. Interleukin-7 Receptor Signaling Network: An Integrated Systems Perspective

    Institute of Scientific and Technical Information of China (English)

    Megan J. Palmer; Vinay S. Mahajan; Lily C. Trajman; Darrell J. Irvine; Douglas A.Lauffenburger; Jianzhu Chen

    2008-01-01

    Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor, the IL-7 receptor (IL-7R), activates multiple pathways that regulate lymphocyte survival, glucose uptake, proliferation and differentiation. There has been much interest in understanding how IL-7 receptor signaling is modulated at multiple interconnected network levels. This review examines how the strength of the signal through the IL-7 receptor is modulated in T and B cells, including the use of shared receptor components, signaling crosstaik, shared interaction domains, feedback loops, integrated gene regulation, muitimerization and ligand competition. We discuss how these network control mechanisms could integrate to govern the properties of IL-7R signaling in lymphocytes in health and disease. Analysis of IL-7receptor signaling at a network level in a systematic manner will allow for a comprehensive approach to understanding the impact of multiple signaling pathways on lymphocyte biology.

  6. Dynamic Vibrotactile Signals for Forward Collision Avoidance Warning Systems

    OpenAIRE

    Meng, Fanxing; Gray, Rob; Ho, Cristy.; Ahtamad, Mujthaba; Spence, Charles

    2015-01-01

    Objective: Four experiments were conducted in order to assess the effectiveness of dynamic vibrotactile collision-warning signals in potentially enhancing safe driving. Background: Auditory neuroscience research has demonstrated that auditory signals that move toward a person are more salient than those that move away. If this looming effect were found to extend to the tactile modality, then it could be utilized in the context of in-car warning signal design. Method: The effectiveness of vari...

  7. Signal amplification in biological and electrical engineering systems: universal role of cascades.

    Science.gov (United States)

    Grubelnik, Vladimir; Dugonik, Bogdan; Osebik, Davorin; Marhl, Marko

    2009-08-01

    In this paper we compare the cascade mechanisms of signal amplification in biological and electrical engineering systems, and show that they share the capacity to considerably amplify signals, and respond to signal changes both quickly and completely, which effectively preserves the form of the input signal. For biological systems, these characteristics are crucial for efficient and reliable cellular signaling. We show that this highly-efficient biological mechanism of signal amplification that has naturally evolved is mathematically fully equivalent with some man-developed amplifiers, which indicates parallels between biological evolution and successful technology development.

  8. Reliability assessments of railway signaling systems: A comparison and evaluation of approaches

    OpenAIRE

    Tang, Lichao

    2015-01-01

    The railway signaling system is the key system to ensure the safe operation of railway traffic. It is therefore important to have a safe and reliable railway signaling system. The railway authority defines requirements that should be complied with. The technical safety report is a vital documentation for the demonstration of fulfillment of requirements to the railway authority. A literature review of the signaling system is presented first. It describes the different technologies used for ...

  9. Statistical Signal Processing in Humanitarian Mine Clerance Systems

    DEFF Research Database (Denmark)

    Karlsen, Brian; Sørensen, Helge Bjarup Dissing; Larsen, Jan;

    2002-01-01

    Denne artikel beskriver kortfattet metoder og resultater relateret til clutterreduktion (clutter: uønskede reflekterede signaler) i jordradar- (eng. ground penetrating radar, GPR) signaler vha. statistiske signalbehandlingsmetoder baseret på Independent Component Analysis (ICA). Formålet ved denn...

  10. Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide

    NARCIS (Netherlands)

    S. Feldt (Sandra); W.W. Batenburg (Wendy); I. Mazak (Istvan); U. Maschke (Ulrike); M. Wellner (Maren); H. Kvakan (Heda); R. Dechend (Ralf); A. Fiebeler (Anette); C. Burckle (Celine); A. Contrepas (Aurelie); A.H.J. Danser (Jan); M. Bader (Michael); G. Nguyen (Genevieve); F.C. Luft (Friedrich); D. Müller (Dominik)

    2008-01-01

    textabstractThe recently cloned (pro)renin receptor [(P)RR] mediates renin-stimulated cellular effects by activating mitogen-activated protein kinases and promotes nonproteolytic prorenin activation. In vivo, (P)RR is said to be blocked with a peptide consisting of 10 amino acids from the prorenin p

  11. TV Trouble-Shooting Manual. Volumes 3-4. Part 1: Block Diagram of Colour TV Receiver and Signal Flow. Student and Instructor's Manuals.

    Science.gov (United States)

    Mukai, Masaaki; Kobayashi, Ryozo

    These volumes are, respectively, the self-instructional student manual and the teacher manual that cover the first set of training topics in this course for television repair technicians. Both volumes contain the following two sections: (1) Functional Block Diagram of a Colour TV Receiver, including information on the video reproduction circuit,…

  12. The virion host shutoff protein of herpes simplex virus 1 blocks the replication-independent activation of NF-κB in dendritic cells in the absence of type I interferon signaling.

    Science.gov (United States)

    Cotter, Christopher R; Kim, Won-keun; Nguyen, Marie L; Yount, Jacob S; López, Carolina B; Blaho, John A; Moran, Thomas M

    2011-12-01

    Immune evasion is a defining feature of the virus-host relationship. During infection, herpes simplex virus type 1 (HSV-1) utilizes multiple proteins to manipulate the host immune response. In the present study, we investigated the mechanism by which the virion host shutoff (vhs) protein blocks the activation of dendritic cells (DCs). Previously, we found that coinfection of wild-type HSV-1 with a panel of RNA viruses resulted in a block to DC activation that was attributable to vhs. These observations led us to hypothesize that the vhs-mediated inhibition was dependent on signaling through the RIG-I-like receptor (RLR) signaling pathway. By examining DCs generated from MAVS (IPS-1) knockout (KO) mice, we determined that RLR/MAVS signaling is not essential for the DC response to HSV-1. We also evaluated the requirement for the type I interferon (IFN) signaling pathway in DC activation following infection with HSV-1 and found that stimulation of DCs with wild-type HSV-1 required intact type I IFN signaling for the production of cytokines, whereas the vhs deletion (vhs(-)) mutant virus activated DCs without the need for exogenous IFN signaling. Comparisons of transcription factor activation in DCs infected with wild-type HSV and the vhs(-) mutant virus revealed that NF-κB activation was inhibited by vhs in the early phase of the infection. In contrast, IRF3 activation was not influenced by vhs. In these studies, measurement of proinflammatory cytokines and type I IFN release from the infected DCs reflected the activation status of these transcription factors. Taken together, the work presented here (i) describes a novel role for the vhs protein as an inhibitor of the early activation of NF-κB during HSV-1 infection of DCs and (ii) offers a mechanistic explanation of how this protein interferes with DC activation.

  13. Auxiliary signal processing system for a multiparameter radar

    Science.gov (United States)

    Chandrasekar, V.; Gray, G. R.; Caylor, I. J.

    1993-01-01

    The design of an auxiliary signal processor for a multiparameter radar is described with emphasis on low cost, quick development, and minimum disruption of radar operations. The processor is based around a low-cost digital signal processor card and personal computer controller. With the use of such a concept, an auxiliary processor was implemented for the NCAR CP-2 radar during a 1991 summer field campaign and allowed measurement of additional polarimetric parameters, namely, the differential phase and the copolar cross correlation. Sample data are presented from both the auxiliary and existing radar signal processors.

  14. Extracting information masked by the chaotic signal of a time-delay system.

    Science.gov (United States)

    Ponomarenko, V I; Prokhorov, M D

    2002-08-01

    We further develop the method proposed by Bezruchko et al. [Phys. Rev. E 64, 056216 (2001)] for the estimation of the parameters of time-delay systems from time series. Using this method we demonstrate a possibility of message extraction for a communication system with nonlinear mixing of information signal and chaotic signal of the time-delay system. The message extraction procedure is illustrated using both numerical and experimental data and different kinds of information signals.

  15. Chaotic system for the detection of periodic signals under the background of strong noise

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    We propose a method to study the chaotic system for the detection of periodic signals in the presence of strong background noise. The numerical experiments indicate that the chaotic system constructed from the modified Duffing-Holmes equation is sensitive to the weak periodic signal mixed with noise, and it has certain immunity to noise. The signal to noise ratio for the system can reach to about -91 dB.

  16. Multi-Purpose Radio Signal Generation System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The MRSiG will be able to replace many of the expensive, highly specialized RF signal generators with cheaper generic boxes that can be customized as the...

  17. Phosphate sink containing two-component signaling systems as tunable threshold devices

    DEFF Research Database (Denmark)

    Amin, Munia; Kothamachu, Varun B; Feliu, Elisenda;

    2014-01-01

    rapid signal termination, whereby one of the RRs acts as a phosphate sink towards the other RR (i.e. the output RR), but also implements a sigmoidal signal-response relationship. We identify two mathematical conditions on system parameters that are necessary for sigmoidal signal-response relationships...

  18. Vitamin D signaling and the differentiation of developing dopamine systems.

    Science.gov (United States)

    Pertile, Renata A N; Cui, Xiaoying; Eyles, Darryl W

    2016-10-01

    Vitamin D regulates multiple factors including those involved in the ontogeny of dopaminergic systems. It has been shown that in neonatal rats maternally deprived of vitamin D, dopamine (DA) turnover is decreased with associated reductions in one catabolic enzyme, catechol-o-methyl transferase (COMT). To directly examine this signaling relationship, in the present study we have over-expressed the vitamin D receptor (VDR) in neuroblastoma SH-SY5Y cells in order to examine the mechanisms by which the active vitamin D hormone, 1,25(OH)2D3, via its receptor VDR, affects DA production and turnover. Our results show that VDR overexpression increases DA neuron differentiation by increasing tyrosine hydroxylase expression, DA production and decreasing the expression of NEUROG2 a marker of immature DA neurons. In the VDR-overexpressing cells, 1,25(OH)2D3 further increased the levels of the DA-metabolites 3-MT and HVA and elevated COMT gene expression. Chromatin immunoprecipitation revealed that 1,25(OH)2D3 increased VDR binding in three regions of the COMT promoter, strongly suggesting direct regulation. In addition, 1,25(OH)2D3 treatment attenuated increased levels of MAOA, DRD2 and VMAT2 gene expression caused by the VDR-overexpression. Taken together, these results show VDR and 1,25(OH)2D3 are directly involved in regulating the expression of dopaminergic-associated genes and that this in vitro neuronal model is a useful tool for identifying the role of 1,25(OH)2D3 in DA neuronal development and maturation. PMID:27450565

  19. Generation of probe signal for feedback cancellation systems

    OpenAIRE

    Odelius, Johan

    2004-01-01

    A common problem of hearing aids is whistling caused by feedback from the loudspeaker back to the microphone. A method of reducing the negative effects, caused by the feedback, is called feedback cancellation. A variant of feedback cancellation uses a probe signal, which is applied to the speaker of the hearing aid and is used to continuously estimate the feedback. Oticon A/S has suggested a master's thesis with the purpose of designing and evaluating an algorithm generating a probe signal fo...

  20. A Combinatorial Method Based on Function Block and Object-Orientation Concepts for Modeling Distributed Real-Time Control Systems

    Directory of Open Access Journals (Sweden)

    Mohsen Sadighi Moshkenani

    2007-06-01

    Full Text Available This paper presents a novel modeling method for distributed real-time control systems. The method uses function blocks model of IEC 61499 standard related to industrial control systems in combination with object-oriented approach for software production. The new modeling technique is named OO+FB. This method models distribution characteristics and real-time constraints accurately and provides a proper background for analysis and design of controllers. The new methodology, gives a complete framework for facing with modern industrial processes, using the good characteristics of both fundamental method. In this paper, different steps of OO+FB is described and advantages of using such a model is discussed, so a reliable approach is introduced for modeling.

  1. 49 CFR 234.9 - Grade crossing signal system failure reports.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Grade crossing signal system failure reports. 234... PLANS Reports and Plans § 234.9 Grade crossing signal system failure reports. Each railroad shall report to FRA within 15 days each activation failure of a highway-rail grade crossing warning system....

  2. Ghost Block

    OpenAIRE

    Webb, Neil

    2011-01-01

    Filmed on the English south coast 'Ghost Block' depicts the uncanny and eerie atmosphere at the site of a WW2 coastal defence line. The concrete cubes were used as an anti-invasion blockade against potential landing forces. This protection line now slowly decaying and becoming enmeshed into the environment still acts as a defence to repel unwanted visitors. The area is a natural reserve to nesting birds that often lay eggs directly onto the beach surface. The blocks act as a final barrier ...

  3. Signal processing system for parallel plate ionization chamber at test beam of BEPC II

    International Nuclear Information System (INIS)

    A signal processing system has been designed in order to read out the electrode signals of 2D parallel plate ionization chamber at test beam facility of BEPC II. The system mainly includes that charge sensitive pre-amplifier, main-amplifier, analog to digital convertor and personal computer. Digital signals were recorded and displayed real time in histograms using data acquirement program based on Linux operating system. This signal processing system can be operated easily and has lower electronic noise and stable performance. (authors)

  4. Low Cost Em Signal Spectral Analysis with Two Element Time Modulated Array System by Multiple Signal Classification Algorithms

    Directory of Open Access Journals (Sweden)

    G. Balagurappa,

    2014-03-01

    Full Text Available Today homeland security is a big matter of concern. The present day wireless technology is available to anti-social elements, who are using this in several undesirable manners. By knowing the direction of the source of electromagnetic waves it becomes possible to locate such anti-social groups and take offensive action. In military applications also finding the direction of the signal source becomes very valuable information. The direction finding systems can achieve this goal. Conventional radio direction finding (RDF systems often use an array of two or more antennas and use either phase-comparison or amplitude-comparison of the received signals to determine direction of arrival information. In both of these techniques directional information is derived by processing array data at the receive signal frequency. In this project an alternative approach to direction finding using the concept of a time-switched array is proposed. The time-switched array system uses simple signal processing techniques to provide a directional main beam and pattern nulls at harmonic frequencies. To determine two dimensional angles is three elements, the system cost has been mostly minimised. we now consider the problem of using our low cost system to detect and estimate the direction of arrival of a desired signal in the presence of array antenna. The proposed scheme is cost effective technique in comparison with the existing schemes. MATLAB/GNU OCTAVE simulation tool will be used for simulation. The simulation results, applications, merits and demerits of proposed approach will be analyzed and will be documented.

  5. A Threats Blocking Plug-in for Open Source Learning Management Systems

    Science.gov (United States)

    Braga, Gianluca; Sterbini, Andrea; Temperini, Marco

    Web-based Learning Management Systems, as in the nature of web-applications, are subject to attacks delivered through Internet, mainly aiming at accessing restricted data for illegal use. Protection from these kinds of threats is studied in the area of web applications and has been steadily improving in the last years. Nonetheless, especially in the area of very popular and easy-to-install web applications, such as Content Managements Systems, Blogs, and open source Learning Management Systems, the usual way to protect an installed system is to wait that weaknesses in the system software are discovered, and "patches" or new system releases are made available for installation. And this can be necessary also in cases in which no new threat technique has been discovered, while just another part of the system software has been detected as "weak" to that type of attack. Here we give an account of the most usual "exploit" techniques, known to be available, and describe a prototype methodology to equip certain Learning Management Systems (namely the open source ones, in particular those based on PHP engines) with a more stable protection, making it unnecessary to patch, or reinstall, a system in a hurry, after that minor weaknesses have been unveiled. The plug-in for a system is supposed to filter the input, sent by the user through a browser, and to avoid execution of server activities on suspect data. We test the methodology on Moodle, by producing a suitable plug-in, and verifying its success at system run-time.

  6. Control of polarization signal distortion by frequency domain phase conjugation in optical fiber systems

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Optical frequency domain phase conjugation(FDPC) is based on phase conjuga-tion of spectrum of an input signal.It is equivalent to the phase conjugation and the time reversal of the temporal envelope of an input signal.The use of FDPC to con-trol polarization signal distortion in birefringent optical fiber systems is proposed.Evolution of polarization signals in the system using midway FDPC is analyzed theoretically and simulated numerically.It is shown that the distortion of polariza-tion signals can be controlled effectively by FDPC.The impairments due to disper-sion and nonlinear effects can be suppressed simultaneously.

  7. Control of polarization signal distortion by frequency domain phase conjusation in optical fiber systems

    Institute of Scientific and Technical Information of China (English)

    BU Yang; WANG XiangZhao

    2008-01-01

    Optical frequency domain phase conjugation (FDPC) is based on phase conjugation of spectrum of an input signal. It is equivalent to the phase conjugation and the time reversal of the temporal envelope of an input signal. The use of FDPC to con-trol polarization signal distortion in birefringent optical fiber systems is proposed. Evolution of polarization signals in the system using midway FDPC is analyzed theoretically and simulated numerically. It is shown that the distortion of polariza-tion signals can be controlled effectively by FDPC. The impairments due to disper-sion and nonlinear effects can be suppressed simultaneously.

  8. A Survey of the Effectiveness of a Signal In a Wireless Analog and Digital System

    OpenAIRE

    Lundholm, Rickard; Bashir, Zaid; Kurowski, Sven

    2015-01-01

    The aim of this paper is to study the different parts of a wireless system in order to better understand the signal properties and what key factors changes the signal during its transmission. Two transmitters were created, an FM transmitter that transmits analog data and an Arudino board programed to convert data to bits before its transmission. The acquired signals were then compared to the original signal noting how differently the data had changed. To understand the antennas contribution t...

  9. Porous block nanofiber composite filters

    Energy Technology Data Exchange (ETDEWEB)

    Ginley, David S.; Curtis, Calvin J.; Miedaner, Alexander; Weiss, Alan J.; Paddock, Arnold

    2016-08-09

    Porous block nano-fiber composite (110), a filtration system (10) and methods of using the same are disclosed. An exemplary porous block nano-fiber composite (110) includes a porous block (100) having one or more pores (200). The porous block nano-fiber composite (110) also includes a plurality of inorganic nano-fibers (211) formed within at least one of the pores (200).

  10. Radiotracers For Lipid Signaling Pathways In Biological Systems

    Energy Technology Data Exchange (ETDEWEB)

    Gatley, S. J. [Northeastern Univ., Boston, MA (United States)

    2016-09-26

    The primary focus of this project continues to be the development of radiotracers and radiotracer methodology for studying physiology and biochemistry. The compounds that have been labeled areacylethanolamines and acylglycerols that are, as classes, represented in both in plants and in animals. In the latter, some of these act as ligands for cannabinoid receptors and they are therefore known as endocannabinoids. Cannabinoid receptors are not found in plant genomes so that plants must contain other receptors and signaling systems that use acylethanolamines. Relatively little work has been done on that issue, though acylethanolamines do modulate plant growth and stress resistance, thus possessing obvious relevance to agriculture and energy production. Progress has been described in five peer-reviewed papers and seven meeting abstracts. Preparation of 2-acylglycerol lipid messengers in high purity. A novel enzymatic synthesis was developedthat gave pure 2-acylglycerols free of any rearrrangement to the thermodynamically more stable 1(3)-acylglycerol byproducts. The method utilized 1,3-dibutyryl-2-acylglycerol substrate ethanolysis by a resinimobilized lipase. Thus, pure radiolabeled 2-acylglycerols can now be conveniently prepared just prior to their utilization. These synthetic studies were published in the Journal of Medicinal Chemistry, 2011. Diacylglycerol lipase assay methodology. Diacylglycerol lipases (DAGLs) generate 2- acylglycerols, and are thus potential targets for disease- or growth-modifying agents, by means of reducing formation of 2-acylglycerols. A radioTLC assay of the hydrolysis of radiolabeled diglyceride substrate [1''-carbon-14]2-arachidonoyl-1-stearoyl-sn-glycerol has been implemented, and used to validate a novel, potentially highthroughput fluorescence resonance energy transfer (FRET) based assay. A number of new DAGL inhibitors that have selectivity for DAGLs were synthesized and screened. This work was very recently published in

  11. Epidural block

    Science.gov (United States)

    ... Drugs & Supplements Videos & Tools Español You Are Here: Home ... It numbs or causes a loss of feeling in the lower half your body. This lessens the pain of contractions during childbirth. An epidural block may also be used to ...

  12. E-Block: A Tangible Programming Tool with Graphical Blocks

    Directory of Open Access Journals (Sweden)

    Danli Wang

    2013-01-01

    Full Text Available This paper designs a tangible programming tool, E-Block, for children aged 5 to 9 to experience the preliminary understanding of programming by building blocks. With embedded artificial intelligence, the tool defines the programming blocks with the sensors as the input and enables children to write programs to complete the tasks in the computer. The symbol on the programming block's surface is used to help children understanding the function of each block. The sequence information is transferred to computer by microcomputers and then translated into semantic information. The system applies wireless and infrared technologies and provides user with feedbacks on both screen and programming blocks. Preliminary user studies using observation and user interview methods are shown for E-Block's prototype. The test results prove that E-Block is attractive to children and easy to learn and use. The project also highlights potential advantages of using single chip microcomputer (SCM technology to develop tangible programming tools for children.

  13. Building Block Apartments Energy Monitoring Interactive System With Social Case Study

    OpenAIRE

    Meyers, Christophe

    2015-01-01

    This report has two aims. First aim is to evaluate the e_ect of installing a home energy monitoring system on the electrical consumption of inhabitants of a Smart City. Numerous literature urges for the need of more informative energy billing; historic, extra information or comparative feedback. This thesis conducts a further evaluation in scope of further validating these _ndings. Second aim is to compare deployment and performance of Open vs commercial energy monitoring systems. Henc...

  14. Establishment of control equations and adjoint equations using block-pulse functions for optimal control of linear systems with time delays

    Institute of Scientific and Technical Information of China (English)

    王兴涛

    2002-01-01

    Control equation and adjoint equation are established by using block-pulse functions, which trans-forms the linear time-varying systems with time delays into a system of algebraic equations and the optimal con-trol problems are transformed into an optimization problem of multivariate functions thereby achieving the opti-mal control of linear systems with time delays.

  15. Mobile measurement system of ECG signal in vehicle environment

    Science.gov (United States)

    Oh, Kwang-seok; Lee, Sang-Ryong; Lee, Choon-Young; Kim, Myun-Hee

    2005-12-01

    This paper proposed a new method to measure the ECG signal from the driver. The ECG signal is often measured in the room. But it is mixed with many kinds of noise when it is measured during the vehicle moving. Noise occupied most many parts as the experimental among them was classified. And one suitable filter for each noise was designed. It used ALE(Adaptive Line Enhancement) to remove the noise occurred to electromagnetic wave in vehicle. To remove the noise occurred to steering or vibration of vehicle, the paper used Wavelet transformation after ALE(preprocessing filter). To realize unconscious measurement, this research used the stainless steel(not the electrode) fixed at steering wheel and designed the adaptive filter without using reference signal.

  16. Radiotracers For Lipid Signaling Pathways In Biological Systems

    Energy Technology Data Exchange (ETDEWEB)

    Gatley, S. J. [Northeastern Univ., Boston, MA (United States)

    2016-09-26

    The primary focus of this project continues to be the development of radiotracers and radiotracer methodology for studying physiology and biochemistry. The compounds that have been labeled areacylethanolamines and acylglycerols that are, as classes, represented in both in plants and in animals. In the latter, some of these act as ligands for cannabinoid receptors and they are therefore known as endocannabinoids. Cannabinoid receptors are not found in plant genomes so that plants must contain other receptors and signaling systems that use acylethanolamines. Relatively little work has been done on that issue, though acylethanolamines do modulate plant growth and stress resistance, thus possessing obvious relevance to agriculture and energy production. Progress has been described in five peer-reviewed papers and seven meeting abstracts. Preparation of 2-acylglycerol lipid messengers in high purity. A novel enzymatic synthesis was developedthat gave pure 2-acylglycerols free of any rearrrangement to the thermodynamically more stable 1(3)-acylglycerol byproducts. The method utilized 1,3-dibutyryl-2-acylglycerol substrate ethanolysis by a resinimobilized lipase. Thus, pure radiolabeled 2-acylglycerols can now be conveniently prepared just prior to their utilization. These synthetic studies were published in the Journal of Medicinal Chemistry, 2011. Diacylglycerol lipase assay methodology. Diacylglycerol lipases (DAGLs) generate 2- acylglycerols, and are thus potential targets for disease- or growth-modifying agents, by means of reducing formation of 2-acylglycerols. A radioTLC assay of the hydrolysis of radiolabeled diglyceride substrate [1''-carbon-14]2-arachidonoyl-1-stearoyl-sn-glycerol has been implemented, and used to validate a novel, potentially highthroughput fluorescence resonance energy transfer (FRET) based assay. A number of new DAGL inhibitors that have selectivity for DAGLs were synthesized and screened. This work was very recently published in

  17. Treatment of metastatic colorectal carcinomas by systemic inhibition of vascular endothelial growth factor signaling in mice

    Institute of Scientific and Technical Information of China (English)

    Volker Schmitz; Miroslaw Kornek; Tobias Hilbert; Christian Dzienisowicz; Esther Raskopf; Christian Rabe; Tilman Sauerbruch; Cheng Qian; Wolfgang H Caselmann

    2005-01-01

    AIM: Tumor angiogenesis has been shown to be promoted by vascular endothelial growth factor (VEGF) via stimulating endothelial cell proliferation, migration, and survival.Blockade of VEGF signaling by different means has been demonstrated to result in reduced tumor growth and suppression of tumor angiogenesis in distinct tumor entities.Here, we tested a recombinant adenovirus, AdsFlt1-3,that encodes an antagonistically acting fragment of the VEGF receptor 1 (Flt-1), for systemic antitumor effects in pre-established subcutaneous CRC tumors in mice.METHODS: Murine colorectal carcinoma cells (CT26) were inoculated subcutaneously into Balb/c mice forin vivo studies. Tumor size and survival were determined. 293cell line was used for propagation of the adenoviral vectors.Human lung cancer line 4549 and human umbilical vein endothelial cells were transfected forin vitro experiments.RESULTS: Infection of tumor cells with AdsFlt1-3 resulted in protein secretion into cell supernatant, demonstrating correct vector function. As expected, the secreted sFlt1-3 protein had no direct effect on CT26 tumor cell proliferation in vitro, but endothelial cell function was inhibited by about 46% as compared to the AdLacZ control in a tube formation assay. When AdsFlt1-3 (5×109 PFU/animal) was applied to tumor bearing mice, we found a tumor inhibition by 72% at d 12 after treatment initiation. In spite of these antitumoral effects, the survival time was not improved.According to reduced intratumoral microvessel density in AdsFlt1-3-treated mice, the antitumor mechanism can be attributed to angiostatic vector effects. We did not detect increased systemic VEGF levels after AdsFlt1-3 treatment and liver toxicity was low as judged by serum alanine aminotransferase determination.CONCLUSION: In this study we confirmed the value of a systemic administration of AdsFlt1-3 to block VEGF signaling as antitumor therapy in an experimental metastatic colorectal carcinoma model in mice.

  18. Vectorcardiogram of complete right bundle branch block with left axis deviation by the Frank and Kimura systems.

    Directory of Open Access Journals (Sweden)

    Nakagawa,Masahiro

    1979-10-01

    Full Text Available Vectorcardiogram (VCG recorded by both the Frank and Kimura systems were examined in 45 patients with complete right bundle branch block (RBBB and left axis deviation (LAD to investigate the relationship seen on electrocardiogram (ECG between RBBB with LAD and bilateral bundle. The sample included: 13 cases of type SI, SII, SIII, SaVF; 21 cases of type SI, SII, SIII, aVF; and 11 cases of types SI, SII, SIII. VCG recorded by the Frank system were classified into seven types according to the QRS loop pattern on the frontal plane and into three types according to the horizontal plane. The main findings were: (a In the Frank system the QRS loop in the frontal plane showed a variety of patterns in RBBB with LAD. (b On VCG of complete RBBB judged complicated by a left anterior hemiblock by the Frank system, the main portion of the QRS loop extended to the left superior or merely to the left in the frontal plane. The direction of rotation and position on the horizontal plane were not consistent. (c The results of this study suggest the usefulness of the Kimura system as an auxiliary diagnostic technique.

  19. An offset tone based gain stabilization technique for mixed-signal RF measurement systems

    Science.gov (United States)

    Joshi, Gopal; Motiwala, Paresh D.; Randale, G. D.; Singh, Pitamber; Agarwal, Vivek; Kumar, Girish

    2015-09-01

    This paper describes a gain stabilization technique for a RF signal measurement system. A sinusoidal signal of known amplitude, phase and close enough in frequency is added to the main, to be measured RF signal at the input of the analog section. The system stabilizes this offset tone in the digital domain, as it is sampled at the output of the analog section. This process generates a correction factor needed to stabilize the magnitude of the gain of the analog section for the main RF signal. With the help of a simple calibration procedure, the absolute amplitude of the main RF signal can be measured. The technique is especially suited for a system that processes signals around a single frequency, employs direct signal conversion into the digital domain, and processes subsequent steps in an FPGA. The inherent parallel signal processing in an FPGA-based implementation allows a real time stabilization of the gain. The effectiveness of the technique is derived from the fact, that the gain stabilization stamped to the main RF signal measurement branch requires only a few components in the system to be inherently stable. A test setup, along with experimental results is presented from the field of RF instrumentation for particle accelerators. Due to the availability of a phase synchronized RF reference signal in these systems, the measured phase difference between the main RF and the RF reference is also stabilized using this technique. A scheme of the signal processing is presented, where a moving average filter has been used to filter out not only the unwanted frequencies, but also to separate the main RF signal from the offset tone signal. This is achieved by a suitable choice of sampling and offset tone frequencies. The presented signal processing scheme is suitable to a variety of RF measurement applications.

  20. The solubilization of fatty acids in systems based on block copolymers and nonionic surfactants

    Science.gov (United States)

    Mirgorodskaya, A. B.; Yatskevich, E. I.; Zakharova, L. Ya.

    2010-12-01

    The solubilizing action of micellar, microemulsion, and polymer-colloid systems formed on the basis of biologically compatible amphiphilic polymers and nonionic surfactants on capric, lauric, palmitic, and stearic acids was characterized quantitatively. Systems based on micelle forming oxyethyl compounds increased the solubility of fatty acids by more than an order of magnitude. Acid molecules incorporated into micelles increased their size and caused structural changes. Solubilization was accompanied by complete or partial destruction of intrinsic acid associates and an increase in their p K a by 1.5-2 units compared with water.

  1. Design and implementation of a hybrid circuit system for micro sensor signal processing*

    Institute of Scientific and Technical Information of China (English)

    Wang Zhuping; Chen Jing; Liu Ruqing

    2011-01-01

    This paper covers a micro sensor analog signal processing circuit system (MASPS) chip with low power and a digital signal processing circuit board implementation including hardware connection and software design.Attention has been paid to incorporate the MASPS chip into the digital circuit board. The ultimate aim is to form a hybrid circuit used for mixed-signal processing, which can be applied to a micro sensor flow monitoring system.

  2. Design and implementation of a hybrid circuit system for micro sensor signal processing

    Energy Technology Data Exchange (ETDEWEB)

    Wang Zhuping; Chen Jing; Liu Ruqing, E-mail: wangzhuping169@163.com [School of Information and Electronics, Beijing Institute of Technology, Beijing 100081 (China)

    2011-04-15

    This paper covers a micro sensor analog signal processing circuit system (MASPS) chip with low power and a digital signal processing circuit board implementation including hardware connection and software design. Attention has been paid to incorporate the MASPS chip into the digital circuit board. The ultimate aim is to form a hybrid circuit used for mixed-signal processing, which can be applied to a micro sensor flow monitoring system. (semiconductor integrated circuits)

  3. PEA System Modeling and Signal Processing for Measurements of Volume Charge Distributions in Thin Dielectric Films

    OpenAIRE

    Pearson, Lee H.; Dennison, JR; Griffiths, Erick W.; Pearson, A. C.

    2016-01-01

    This paper discusses an effort to develop advanced pulsed electroacoustic (PEA) measurement system capabilities that incorporate state-of-the-art hardware and improved signal processing and modeling to characterize embedded charge distributions in thin dielectric films. Objectives in developing this system include: (1) improved spatial resolution, while maintaining reasonable temporal resolution; (2) improved signal processing tools for increased signal/noise ratios; (3) integrated PEA modeli...

  4. Generation of linearized optical single sideband signal for broadband radio over fiber systems

    Institute of Scientific and Technical Information of China (English)

    Tao Wang; Qingjiang Chang; Yikai Su

    2009-01-01

    We propose a new scheme to generate broadband linearized optical single-sideband (OSSB) signal for radio over fiber systems. By using an unbalanced dual parallel Mach-zehnder modulator (DPMZM) followed by optical filtering, a linearized OSSB signal is obtained. With coherent detection, radio frequency (RF) signal can be recovered with simultaneously suppressed second-order distortion and third-order intermodulation. This scheme can be used to realize broadband systems with wide dynamic range.

  5. FPGA Implementation of Block Parallel DF-MPIC Detectors for DS-CDMA Systems in Frequency-Nonselective Channels

    Directory of Open Access Journals (Sweden)

    Adel Omar Dahmane

    2008-01-01

    Full Text Available Multistage parallel interference cancellation- (MPIC- based detectors allow to mitigate multiple-access interference in direct-sequence code-division multiple-access (DS-CDMA systems. They are considered serious candidates for practical implementation showing a good tradeoff between performance and complexity. Better performance is obtained when decision feedback (DF is employed. Although MPIC and DF-MPIC have the same arithmetic complexity, DF-MPIC needs much more FPGA resources when compared to MPIC without decision feedback. In this letter, FPGA implementation of block parallel DF-MPIC (BP-DF-MPIC is proposed allowing better tradeoff between performance and FPGA area occupancy. To reach an uncoded bit-error rate of 10−3, BP-DF-MPIC shows a 1.5 dB improvement over the MPIC without decision feedback with only 8% increase in FPGA resources compared to 69% for DF-MPIC.

  6. Time-resolved single-photon detection module based on silicon photomultiplier: A novel building block for time-correlated measurement systems.

    Science.gov (United States)

    Martinenghi, E; Di Sieno, L; Contini, D; Sanzaro, M; Pifferi, A; Dalla Mora, A

    2016-07-01

    We present the design and preliminary characterization of the first detection module based on Silicon Photomultiplier (SiPM) tailored for single-photon timing applications. The aim of this work is to demonstrate, thanks to the design of a suitable module, the possibility to easily exploit SiPM in many applications as an interesting detector featuring large active area, similarly to photomultipliers tubes, but keeping the advantages of solid state detectors (high quantum efficiency, low cost, compactness, robustness, low bias voltage, and insensitiveness to magnetic field). The module integrates a cooled SiPM with a total photosensitive area of 1 mm(2) together with the suitable avalanche signal read-out circuit, the signal conditioning, the biasing electronics, and a Peltier cooler driver for thermal stabilization. It is able to extract the single-photon timing information with resolution better than 100 ps full-width at half maximum. We verified the effective stabilization in response to external thermal perturbations, thus proving the complete insensitivity of the module to environment temperature variations, which represents a fundamental parameter to profitably use the instrument for real-field applications. We also characterized the single-photon timing resolution, the background noise due to both primary dark count generation and afterpulsing, the single-photon detection efficiency, and the instrument response function shape. The proposed module can become a reliable and cost-effective building block for time-correlated single-photon counting instruments in applications requiring high collection capability of isotropic light and detection efficiency (e.g., fluorescence decay measurements or time-domain diffuse optics systems). PMID:27475542

  7. Time-resolved single-photon detection module based on silicon photomultiplier: A novel building block for time-correlated measurement systems

    Science.gov (United States)

    Martinenghi, E.; Di Sieno, L.; Contini, D.; Sanzaro, M.; Pifferi, A.; Dalla Mora, A.

    2016-07-01

    We present the design and preliminary characterization of the first detection module based on Silicon Photomultiplier (SiPM) tailored for single-photon timing applications. The aim of this work is to demonstrate, thanks to the design of a suitable module, the possibility to easily exploit SiPM in many applications as an interesting detector featuring large active area, similarly to photomultipliers tubes, but keeping the advantages of solid state detectors (high quantum efficiency, low cost, compactness, robustness, low bias voltage, and insensitiveness to magnetic field). The module integrates a cooled SiPM with a total photosensitive area of 1 mm2 together with the suitable avalanche signal read-out circuit, the signal conditioning, the biasing electronics, and a Peltier cooler driver for thermal stabilization. It is able to extract the single-photon timing information with resolution better than 100 ps full-width at half maximum. We verified the effective stabilization in response to external thermal perturbations, thus proving the complete insensitivity of the module to environment temperature variations, which represents a fundamental parameter to profitably use the instrument for real-field applications. We also characterized the single-photon timing resolution, the background noise due to both primary dark count generation and afterpulsing, the single-photon detection efficiency, and the instrument response function shape. The proposed module can become a reliable and cost-effective building block for time-correlated single-photon counting instruments in applications requiring high collection capability of isotropic light and detection efficiency (e.g., fluorescence decay measurements or time-domain diffuse optics systems).

  8. Improvement of Small Signal Stability of SMIB System Using PSO and CSO based Power System Stabilizer

    Directory of Open Access Journals (Sweden)

    Y. Raghuvamsi

    2015-08-01

    Full Text Available In a power system, Low Frequency Oscillations (LFOs are dangerous and make system unstable. These oscillations are referred to small signal stability and they are mainly due to lack of damping torque. This insufficient damping torque is because of high gain and low time constant of Automatic Voltage Regulator (AVR. AVR is useful for maintaining the terminal voltage of synchronous machine as constant. While doing so, it will make the system damping torque as negative. For providing required damping torque thereby minimizing the LFOs, Power System Stabilizer is used in conjunction with AVR. In this paper for SMIB system, the stability is studied with the help of eigen values before and after placement of PSS with optimized PSS parameters using Particle Swarm Optimization (PSO and Cat Swarm Optimization (CSO. The simulation work is performed in the MATLAB/SIMULINK and corresponding results are presented and analyzed.

  9. Screening system of blocking agents of the receptor for advanced glycation endproducts in cells using fluorescence.

    Science.gov (United States)

    Jung, Dong Ho; Kim, Young Sook; Kim, Jin Sook

    2012-01-01

    Activation of the receptor for advanced glycation endproducts (RAGE) triggers cellular responses implicated in the pathogenesis of diabetic complications; blockade of RAGE has been shown to inhibit the development of diabetic complications. To develop a screening system to identify novel disruptors of advanced glycation endproducts (AGE)-RAGE binding, we used an AGE-RAGE binding system in RAGE-overexpressing cells; test compounds were screened using this system. To construct human RAGE-overexpressing cells, mouse mesangial cells (MMCs) were stably transfected with the pcDNA-human RAGE (hRAGE) vector and selected under 1 mg/mL gentamicin (G418). RAGE expression in hRAGE-overexpressing MMCs was analyzed by Western blotting with specific RAGE antibody. To identify novel disruptors of AGE-RAGE binding, 50 single compounds and AGE-bovine serum albumin (BSA)-Alexa 488 (AGE-BSA labeled with Alexa 488) were treated to the hRAGE-overexpressing MMCs. Nonbinding AGE-BSA-Alexa 488 was washed and fluorescence measured by microtiter plate reader (excitation wavelength, 485 nm; emission wavelength, 528 nm). In hRAGE-overexpressing cells, only treatment with AGE-BSA-Alexa 488 significantly increased fluorescence intensity in a dose-dependent manner. Of 50 compounds tested, genistein disrupted AGE-RAGE binding in a dose-dependent manner. This AGE-RAGE binding system using AGE-BSA-Alexa 488 in hRAGE-overexpressing cells was suitable for screening of agents that disrupt AGE-hRAGE binding.

  10. Reduction of Under-Determined Linear Systems by Sparce Block Matrix Technique

    DEFF Research Database (Denmark)

    Tarp-Johansen, Niels Jacob; Poulsen, Peter Noe; Damkilde, Lars

    1996-01-01

    Under-determined linear equation systems occur in different engineering applications. In structural engineering they typically appear when applying the force method. As an example one could mention limit load analysis based on The Lower Bound Theorem. In this application there is a set of under...

  11. Uncoupling High Light Responses from Singlet Oxygen Retrograde Signaling and Spatial-Temporal Systemic Acquired Acclimation.

    Science.gov (United States)

    Carmody, Melanie; Crisp, Peter A; d'Alessandro, Stefano; Ganguly, Diep; Gordon, Matthew; Havaux, Michel; Albrecht-Borth, Verónica; Pogson, Barry J

    2016-07-01

    Distinct ROS signaling pathways initiated by singlet oxygen ((1)O2) or superoxide and hydrogen peroxide have been attributed to either cell death or acclimation, respectively. Recent studies have revealed that more complex antagonistic and synergistic relationships exist within and between these pathways. As specific chloroplastic ROS signals are difficult to study, rapid systemic signaling experiments using localized high light (HL) stress or ROS treatments were used in this study to uncouple signals required for direct HL and ROS perception and distal systemic acquired acclimation (SAA). A qPCR approach was chosen to determine local perception and distal signal reception. Analysis of a thylakoidal ascorbate peroxidase mutant (tapx), the (1)O2-retrograde signaling double mutant (ex1/ex2), and an apoplastic signaling double mutant (rbohD/F) revealed that tAPX and EXECUTER 1 are required for both HL and systemic acclimation stress perception. Apoplastic membrane-localized RBOHs were required for systemic spread of the signal but not for local signal induction in directly stressed tissues. Endogenous ROS treatments revealed a very strong systemic response induced by a localized 1 h induction of (1)O2 using the conditional flu mutant. A qPCR time course of (1)O2 induced systemic marker genes in directly and indirectly connected leaves revealed a direct vascular connection component of both immediate and longer term SAA signaling responses. These results reveal the importance of an EXECUTER-dependent (1)O2 retrograde signal for both local and long distance RBOH-dependent acclimation signaling that is distinct from other HL signaling pathways, and that direct vascular connections have a role in spatial-temporal SAA induction. PMID:27288360

  12. Fast optical signal processing in high bit rate OTDM systems

    DEFF Research Database (Denmark)

    Poulsen, Henrik Nørskov; Jepsen, Kim Stokholm; Clausen, Anders;

    1998-01-01

    As all-optical signal processing is maturing, optical time division multiplexing (OTDM) has also gained interest for simple networking in high capacity backbone networks. As an example of a network scenario we show an OTDM bus interconnecting another OTDM bus, a single high capacity user...

  13. Antenna Array Signal Processing for Multistatic Radar Systems

    NARCIS (Netherlands)

    Belfiori, F.

    2013-01-01

    The introductions of Digital Beam Forming (DBF), original signal exploitation and waveform multiplexing techniques have led to the design of novel radar concepts. Passive Coherent Locator (PCL) and Multiple-Input Multiple-Output (MIMO) sensors are two examples of innovative approaches. Beside the in

  14. Integration System of Head, Eye, and Retinal Position Signals for Perceptual Direction

    Science.gov (United States)

    Yamaguchi, Masashi; Kaneko, Hirohiko

    2007-11-01

    This study investigates the integration system of head (-to-trunk), eye (-to-head), and retinal position signals for hand pointing. In experiment 1, subjects changed their head and eye positions and pointed at a fixated visual stimulus by using an unseen pointer. In experiment 2, subjects fixated a visual stimulus and pointed at another visual stimulus. The results show that the head and eye position signals contributed linearly to perceptual direction (experiments 1 and 2), and that the coefficients of these signals decrease with peripheral vision and are smaller than the coefficient of the retinal position signal (experiment 2). These results collectively suggest that the integration algorithm of the position signals might be described by the linear summation equation and that the retinal position signal serves a more important role than the other position signals in the visual system.

  15. Huhe Block

    Institute of Scientific and Technical Information of China (English)

    1996-01-01

    @@ Huhe Block is located in the mid-west part of Inner Mogolia Autonomous Region, covering an area of 15 079km2, in the range of 109°40'-112°00'E and 39°23()-40°40'N. Topographically. the Fengzhen hill is to the east, the Yinshan Mounts is to the north, the Hetao Plain and Ordos Plateau are respectively in its west and south.The Yellow River flows across this block. The elevation is 1 000 m in the flat area and in the range of 1 000-1 300m. in the plateau area, good for the development of agriculture and industry as well as husbandry. It belongs to inland plateau climate with annually averaged temperature of 8℃, the minimum being -12℃ in winter and the maximum 22℃ in summer.

  16. A Simulated System for Traffic Signal Management Based on Integrating GIS & WSN Techniques

    Directory of Open Access Journals (Sweden)

    Ahmed S. Elmotelb

    2016-01-01

    Full Text Available Traffic signals management systems (TSMS are traffic systems based on cameras, infrared sensors and satellite systems. Such systems have been lacking the ability of real-time data collection and support. This paper proposes a solution to the traffic signal management problem using combined techniques that combines both GIS information with WSN based techniques. This combination provide appropriate techniques and tools that will enhance the capabilities of traffic jam prevention, early detection, efficient surveillance, efficient spread control, and fast termination of possible hazards. Consequently, this work proposes a new methodology thrown merging WSN and GIS techniques to produce valuable information for traffic signals management systems purposes.

  17. Reservoir computing with a slowly modulated mask signal for preprocessing using a mutually coupled optoelectronic system

    Science.gov (United States)

    Tezuka, Miwa; Kanno, Kazutaka; Bunsen, Masatoshi

    2016-08-01

    Reservoir computing is a machine-learning paradigm based on information processing in the human brain. We numerically demonstrate reservoir computing with a slowly modulated mask signal for preprocessing by using a mutually coupled optoelectronic system. The performance of our system is quantitatively evaluated by a chaotic time series prediction task. Our system can produce comparable performance with reservoir computing with a single feedback system and a fast modulated mask signal. We showed that it is possible to slow down the modulation speed of the mask signal by using the mutually coupled system in reservoir computing.

  18. Analysis of a kind of Duffing oscillator system used to detect weak signals

    Institute of Scientific and Technical Information of China (English)

    Li Yue; Yang Bao-Jun; Yuan Ye; Liu Xiao-Hua

    2007-01-01

    The stability of the periodic solution of the Duffing oscillator system in the periodic phase state is proved by using the Yoshizaw theorem, which establishes a theoretical basis for using this kind of chaotic oscillator system to detect weak signals. The restoring force term of the system affects the weak-signal detection ability of the system directly,the quantitative relationship between the coefficients of the linear and nonlinear items of the restoring force of the Duffing oscillator system and the SNR in the detection of weak signals is obtained through a large number of simulation experiments, then a new restoring force function with better detection results is established.

  19. A design of an uncooled thermal imaging system to block image blurring using an optimum detector warm shield

    Science.gov (United States)

    Jeong, Junho; Youn, Byungyeol; Shin, Sanghoon; Park, Sangyeong; Kim, Youngjin; Lee, Jungsuk; Kim, Kihong

    2009-05-01

    Uncooled TIS is in the spotlight for its small size and low-voltage operation for personal and portable use compare to other TIS. Generally, uncooled TIS using temperature control by TEC converts the gap between TEC temperature and input-image into voltage by ROIC and outputs the analog image. For cooled detector, it is possible to block undesirable infrared input since F number of the optics and the detector are same but for uncooled detector, it is easy to get undesirable infrared input around because the F numbers are different. It becomes more obvious when temperature gap between the equipment and background gets bigger. For TIS, background temperature easily changes inside the system and around the detector because the radiating heat from the electrical circuit inside the system is getting higher as usage time passes, and it makes worse the non-uniformity output characteristics of the detector. In particular, the temperature change of the system itself which depends on its setting position and other temperaturechanging factors like electrical circuit inside the system make the additional non-uniformity worse which caused by infrared photon radiates from structures which includes optics and detector. This article would indicate the method of minimizing its image blurring which originates from the F number gap between optics and detector.

  20. Multi-Aperture Miniaturized Star Sensors, Modular Building Blocks for Small Satellite AOCS Systems

    OpenAIRE

    Rotteveel, Jeroen; Le Mair, Anita

    2009-01-01

    Accurate attitude determination is an important enabler for micro- and nanosatellite missions. For remote sensing applications and formation flying missions, the attitude of the spacecraft must be known and controlled with a high accuracy. ISIS introduces a modular and scalable attitude determination system based on a multi-aperture miniature star sensor. Based on a patented concept, the Multi-Aperture Baffled Starsensor, the attitude sensor integrates several apertures into a single star tra...

  1. Part and Parcel of the Cardiac Autonomic Nerve System: Unravelling Its Cellular Building Blocks during Development

    OpenAIRE

    Végh, Anna M D; Duim, Sjoerd N; Smits, Anke M; Robert E Poelmann; Arend D. J. ten Harkel; DeRuiter, Marco C; Marie José Goumans; Monique R M Jongbloed

    2016-01-01

    The autonomic nervous system (cANS) is essential for proper heart function, and complications such as heart failure, arrhythmias and even sudden cardiac death are associated with an altered cANS function. A changed innervation state may underlie (part of) the atrial and ventricular arrhythmias observed after myocardial infarction. In other cardiac diseases, such as congenital heart disease, autonomic dysfunction may be related to disease outcome. This is also the case after heart transplantat...

  2. Sequence System Building Blocks: Using a Component Architecture for Sequencing Software

    Science.gov (United States)

    Streiffert, Barbara A.; O'Reilly, Taifun

    2005-01-01

    Over the last few years software engineering has made significant strides in making more flexible architectures and designs possible. However, at the same time, spacecraft have become more complex and flight software has become more sophisticated. Typically spacecraft are often one-of-a-kind entities that have different hardware designs, different capabilities, different instruments, etc. Ground software has become more complex and operations teams have had to learn a myriad of tools that all have different user interfaces and represent data in different ways. At Jet Propulsion Laboratory (JPL) these themes have collided to require an new approach to producing ground system software. Two different groups have been looking at tackling this particular problem. One group is working for the JPL Mars Technology Program in the Mars Science Laboratory (MSL) Focused Technology area. The other group is the JPL Multi-Mission Planning and Sequencing Group . The major concept driving these two approaches on a similar path is to provide software that can be a more cohesive flexible system that provides a act of planning and sequencing system of services. This paper describes the efforts that have been made to date to create a unified approach from these disparate groups.

  3. Sequencing System Building Blocks: Using a Component Architecture for Sequencing Software

    Science.gov (United States)

    Streiffert, Barbara A.; O'Reilly, Taifun

    2006-01-01

    Over the last few years software engineering has made significant strides in making more flexible architectures and designs possible. However, at the same time, spacecraft have become more complex and flight software has become more sophisticated. Typically spacecraft are often one-of-a-kind entities that have different hardware designs, different capabilities, different instruments, etc. Ground software has become more complex and operations teams have had to learn a myriad of tools that all have different user interfaces and represent data in different ways. At Jet Propulsion Laboratory (JPL) these themes have collided to require a new approach to producing ground system software. Two different groups have been looking at tackling this particular problem. One group is working for the JPL Mars Technology Program in the Mars Science Laboratory (MSL) Focused Technology area. The other group is the JPL Multi-Mission Planning and Sequencing Group. The major concept driving these two approaches on a similar path is to provide software that can be a more cohesive flexible system that provides a set of planning and sequencing system of services. This paper describes the efforts that have been made to date to create a unified approach from these disparate groups.

  4. Building blocks of a fish head: Developmental and variational modularity in a complex system.

    Science.gov (United States)

    Lehoux, Caroline; Cloutier, Richard

    2015-11-01

    Evolution of the vertebrate skull is developmentally constrained by the interactions among its anatomical systems, such as the dermatocranium and the sensory system. The interaction between the dermal bones and lateral line canals has been debated for decades but their morphological integration has never been tested. An ontogenetic series of 97 juvenile and adult Amia calva (Actinopterygii) was used to describe the patterning and modularity of sensory lateral line canals and their integration with supporting cranial bones. Developmental modules were tested for the otic canal and supratemporal commissure by computing correlations in the branching sequence of groups of pores. Landmarks were digitized on 25 specimens to test a priori hypotheses of variational and developmental modularity at the level of canals and dermal bones. Branching sequence suggests a specific patterning supported by significant positive correlations in the sequence of appearance of branches between bilateral sides. Differences in patterning between the otic canal and the supratemporal commissure and tests of modularity with geometric morphometrics suggest that both canals form distinct modules. The integration between bones and canals was insufficient to detect a module. However, both components were not independent. Groups of pores tended to disappear without affecting other groups of pores suggesting that they are quasi-independent units acting as modules. This study provides evidence of a hierarchical organization for the modular sensory system that could explain variation of pattern of canals among species and their association with dermal bones. PMID:26227536

  5. Block copolymer battery separator

    Energy Technology Data Exchange (ETDEWEB)

    Wong, David; Balsara, Nitash Pervez

    2016-04-26

    The invention herein described is the use of a block copolymer/homopolymer blend for creating nanoporous materials for transport applications. Specifically, this is demonstrated by using the block copolymer poly(styrene-block-ethylene-block-styrene) (SES) and blending it with homopolymer polystyrene (PS). After blending the polymers, a film is cast, and the film is submerged in tetrahydrofuran, which removes the PS. This creates a nanoporous polymer film, whereby the holes are lined with PS. Control of morphology of the system is achieved by manipulating the amount of PS added and the relative size of the PS added. The porous nature of these films was demonstrated by measuring the ionic conductivity in a traditional battery electrolyte, 1M LiPF.sub.6 in EC/DEC (1:1 v/v) using AC impedance spectroscopy and comparing these results to commercially available battery separators.

  6. Study of Intelligent Photovoltaic System Fault Diagnostic Scheme Based on Chaotic Signal Synchronization

    Directory of Open Access Journals (Sweden)

    Chin-Tsung Hsieh

    2013-01-01

    Full Text Available As the photovoltaic system consists of many equipment components, manual inspection will be very costly. This study proposes the photovoltaic system fault diagnosis based on chaotic signal synchronization. First, MATLAB was used to simulate the fault conditions of solar system, and the maximum power point tracking (MPPT was used to ensure the system's stable power and capture and record the system fault feature signals. The dynamic errors of various fault signals were extracted by chaotic signal synchronization, and the dynamic error data of various fault signals were recorded completely. In the photovoltaic system, the captured output voltage signal was used as the characteristic values for fault recognition, and the extension theory was used to create the joint domain and classical domain of various fault conditions according to the collected feature data. The matter-element model of extension engineering was constructed. Finally, the whole fault diagnosis system is only needed to capture the voltage signal of the solar photovoltaic system, so as to know the exact fault condition effectively and rapidly. The proposed fault diagnostor can be implemented by embedded system and be combined with ZigBee wireless network module in the future, thus reducing labor cost and building a complete portable renewable energy system fault diagnostor.

  7. Throughput-Distortion Computation Of Generic Matrix Multiplication: Toward A Computation Channel For Digital Signal Processing Systems

    CERN Document Server

    Anastasia, Davide

    2011-01-01

    The generic matrix multiply (GEMM) function is the core element of high-performance linear algebra libraries used in many computationally-demanding digital signal processing (DSP) systems. We propose an acceleration technique for GEMM based on dynamically adjusting the imprecision (distortion) of computation. Our technique employs adaptive scalar companding and rounding to input matrix blocks followed by two forms of packing in floating-point that allow for concurrent calculation of multiple results. Since the adaptive companding process controls the increase of concurrency (via packing), the increase in processing throughput (and the corresponding increase in distortion) depends on the input data statistics. To demonstrate this, we derive the optimal throughput-distortion control framework for GEMM for the broad class of zero-mean, independent identically distributed, input sources. Our approach converts matrix multiplication in programmable processors into a computation channel: when increasing the processi...

  8. Signal modulating noise effect in bistable stochastic resonance systems and its analog simulation

    Institute of Scientific and Technical Information of China (English)

    XIAO Fang-hong; YAN Gui-rong; XIE Shi-cheng

    2006-01-01

    The effect of signal modulating noise in bistable stochastic resonance systems was studied theoretically and experimentally. A mathematical analysis was made on the bistable stochastic resonance model with small system parameters. An analogue circuit was designed to perform the effect. The effect of signal modulating noise was shown in the analog simulation experiment. The analog experiment was conducted for two sinusoidal signals with different frequencies. The results show that there are a sinusoidal component corresponding to the input sinusoidal signal and a noise component presented as a Wiener process corresponding to the input white noise in the system output. By properly selecting system parameters, the effect of signal modulating noise can be manifested in the system output.

  9. Fast Detection of Weak Singularities in a Chaotic Signal Using Lorenz System and the Bisection Algorithm

    Directory of Open Access Journals (Sweden)

    Tiezheng Song

    2012-01-01

    Full Text Available Signals with weak singularities are important for condition monitoring, fault forecasting, and medicine diagnosis. However, the weak singularity in a signal is usually hidden by strong noise. A novel fast method is proposed for detecting a weak singularity in a noised signal by determining a critical threshold towards chaos for the Lorenz system. First, a rough critical threshold value is calculated by local Lyapunov exponents with a step size 0.1. Second, the exact threshold value is calculated by the bisection algorithm. The advantage of the method will not only reduce the computation costs, but also show the weak singular signal which can be accurately identified from strong noise. When the variance of an external signal method embeds into a Lorenz system, according to the parametric equivalent relation between the Lorenz system and the original system, the critical threshold value of the parameter in a Lorenz system is determined.

  10. 49 CFR 236.205 - Signal control circuits; requirements.

    Science.gov (United States)

    2010-10-01

    ..., INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Automatic... when any of the following conditions obtain within the block: (a) Occupancy by a train, locomotive,...

  11. Component/Connection/Signal Modeling of Accelerator Systems

    CERN Document Server

    Dohan, Donald

    2005-01-01

    This paper presents a pragmatic global approach to data modeling a complex facility such as a particle accelerator. By successively partitioning the facility into collaborating subsystems, one eventually arrives at the component level-the point at which the subsystem is replaceable as a single unit. The fundamental goal of the model is to capture the dynamical relationships (i.e., the connections) that exist among the accelerator components. Components participate in one or more of three connection types: control, housing, and power. These connections are captured in a multi-hierarchical model capable of handling any component of the accelerator, from the macro scale (magnets, power supplies, racks, etc.) to the embedded scale (circuit board components), if desired. The connection approach has been used to model the signal flows between the component via their port connections. The result is a schema for a cable database that provides end-to-end signal tracing throughout the facility. The paper will discuss t...

  12. Numerical simulation of the slip power recovery system using functional adapted blocks

    Energy Technology Data Exchange (ETDEWEB)

    Marques, G.D. [Technical University of Lisbon, Instituto Superior Tecnico, Seccao de Maquinas Electricas e de Electronica de Potencia, Lisboa (Portugal)

    2000-08-01

    This paper presents a numerical simulation method for the Slip Power Recovery System. The dq induction machine model using stator flux linkages as state variables is used. This leads to a simple and efficient computer program. The diode bridge rectifier is modeled using three switching functions that are determined by the sign of the corresponding AC currents. The model obtained is very simple and accurately represents the three-phase diode bridge rectifier including the current commutation process. When a DC current circuit is used in the intermediate circuit, a model of the whole 'Induction machine and diode bridge rectifier' should be used in other simulation methods. In this paper a different approach is presented. The operations performed to model the system are equivalent to assume that the induction machine has two state variables, i.e, the stator flux linkages. From the rotor point of view, the induction machine is equivalent to a three-phase RLE circuit. MATLAB/Simulink is used to integrate the equations. Experimental and simulated results are presented and compared showing good accuracy. (orig.)

  13. Part and Parcel of the Cardiac Autonomic Nerve System: Unravelling Its Cellular Building Blocks during Development

    Directory of Open Access Journals (Sweden)

    Anna M. D. Végh

    2016-09-01

    Full Text Available The autonomic nervous system (cANS is essential for proper heart function, and complications such as heart failure, arrhythmias and even sudden cardiac death are associated with an altered cANS function. A changed innervation state may underlie (part of the atrial and ventricular arrhythmias observed after myocardial infarction. In other cardiac diseases, such as congenital heart disease, autonomic dysfunction may be related to disease outcome. This is also the case after heart transplantation, when the heart is denervated. Interest in the origin of the autonomic nerve system has renewed since the role of autonomic function in disease progression was recognized, and some plasticity in autonomic regeneration is evident. As with many pathological processes, autonomic dysfunction based on pathological innervation may be a partial recapitulation of the early development of innervation. As such, insight into the development of cardiac innervation and an understanding of the cellular background contributing to cardiac innervation during different phases of development is required. This review describes the development of the cANS and focuses on the cellular contributions, either directly by delivering cells or indirectly by secretion of necessary factors or cell-derivatives.

  14. New Train Run Monitoring system: Getting the most out of an ERTMS level 2 Signalling system

    DEFF Research Database (Denmark)

    Richter, Troels; Landex, Alex; Andersen, Jonas Lohmann Elkjær

    advantage of the additional data delivered by the new systems. The conceptual design of a new RDS has consequently been underway since the start of the signalling program. The vision is to create an automatic system that delivers “perfect train run histories” with a cause for every time loss. The future...... ERTMS Traffic Management System will include a rescheduler: Every time a train leaves its path, a rescheduling is triggered and the train receives a new timetable. As a part of this process, other trains may also be rescheduled. A concept for converting this information into the “perfect train run......The present Punctuality Monitoring and Reporting System (RDS) of Rail Net Denmark uses occupation of main track circuits as source for arrival and departure times on the most intensively used parts of the Danish rail network. On the rest of the network, these times are manually registered...

  15. Unveiling Hidden Dynamics of Hippo Signalling: A Systems Analysis.

    Science.gov (United States)

    Shin, Sung-Young; Nguyen, Lan K

    2016-01-01

    The Hippo signalling pathway has recently emerged as an important regulator of cell apoptosis and proliferation with significant implications in human diseases. In mammals, the pathway contains the core kinases MST1/2, which phosphorylate and activate LATS1/2 kinases. The pro-apoptotic function of the MST/LATS signalling axis was previously linked to the Akt and ERK MAPK pathways, demonstrating that the Hippo pathway does not act alone but crosstalks with other signalling pathways to coordinate network dynamics and cellular outcomes. These crosstalks were characterised by a multitude of complex regulatory mechanisms involving competitive protein-protein interactions and phosphorylation mediated feedback loops. However, how these different mechanisms interplay in different cellular contexts to drive the context-specific network dynamics of Hippo-ERK signalling remains elusive. Using mathematical modelling and computational analysis, we uncovered that the Hippo-ERK network can generate highly diverse dynamical profiles that can be clustered into distinct dose-response patterns. For each pattern, we offered mechanistic explanation that defines when and how the observed phenomenon can arise. We demonstrated that Akt displays opposing, dose-dependent functions towards ERK, which are mediated by the balance between the Raf-1/MST2 protein interaction module and the LATS1 mediated feedback regulation. Moreover, Ras displays a multi-functional role and drives biphasic responses of both MST2 and ERK activities; which are critically governed by the competitive protein interaction between MST2 and Raf-1. Our study represents the first in-depth and systematic analysis of the Hippo-ERK network dynamics and provides a concrete foundation for future studies. PMID:27527217

  16. Unveiling Hidden Dynamics of Hippo Signalling: A Systems Analysis

    Directory of Open Access Journals (Sweden)

    Sung-Young Shin

    2016-08-01

    Full Text Available The Hippo signalling pathway has recently emerged as an important regulator of cell apoptosis and proliferation with significant implications in human diseases. In mammals, the pathway contains the core kinases MST1/2, which phosphorylate and activate LATS1/2 kinases. The pro-apoptotic function of the MST/LATS signalling axis was previously linked to the Akt and ERK MAPK pathways, demonstrating that the Hippo pathway does not act alone but crosstalks with other signalling pathways to coordinate network dynamics and cellular outcomes. These crosstalks were characterised by a multitude of complex regulatory mechanisms involving competitive protein-protein interactions and phosphorylation mediated feedback loops. However, how these different mechanisms interplay in different cellular contexts to drive the context-specific network dynamics of Hippo-ERK signalling remains elusive. Using mathematical modelling and computational analysis, we uncovered that the Hippo-ERK network can generate highly diverse dynamical profiles that can be clustered into distinct dose-response patterns. For each pattern, we offered mechanistic explanation that defines when and how the observed phenomenon can arise. We demonstrated that Akt displays opposing, dose-dependent functions towards ERK, which are mediated by the balance between the Raf-1/MST2 protein interaction module and the LATS1 mediated feedback regulation. Moreover, Ras displays a multi-functional role and drives biphasic responses of both MST2 and ERK activities; which are critically governed by the competitive protein interaction between MST2 and Raf-1. Our study represents the first in-depth and systematic analysis of the Hippo-ERK network dynamics and provides a concrete foundation for future studies.

  17. Clipping noise cancellation in OFDM systems using oversampled signal reconstruction

    OpenAIRE

    Saeedi, Hamid; Sharif, Masoud; Marvasti, Farokh

    2002-01-01

    Clipping the OFDM signals in the digital part of the transmitter is one of the simplest methods to reduce the peak factor. However, it suffers from additional clipping distortion, peak regrowth after digital to analog conversion, and out-of-band radiation in the case of oversampled sequence clipping. We use oversampled sequence clipping to combat the effect of peak regrowth and propose a method to reconstruct the clipped samples and mitigate the clipping distortion in the presence of channel ...

  18. Non-Dioxin-Like Polychlorinated Biphenyls Inhibit G-Protein Coupled Receptor-Mediated Ca2+ Signaling by Blocking Store-Operated Ca2+ Entry.

    Directory of Open Access Journals (Sweden)

    Se-Young Choi

    Full Text Available Polychlorinated biphenyls (PCBs are ubiquitous pollutants which accumulate in the food chain. Recently, several molecular mechanisms by which non-dioxin-like (NDL PCBs mediate neurodevelopmental and neurobehavioral toxicity have been elucidated. However, although the G-protein coupled receptor (GPCR is a significant target for neurobehavioral disturbance, our understanding of the effects of PCBs on GPCR signaling remains unclear. In this study, we investigated the effects of NDL-PCBs on GPCR-mediated Ca2+ signaling in PC12 cells. We found that ortho-substituted 2,2',6-trichlorinated biphenyl (PCB19 caused a rapid decline in the Ca2+ signaling of bradykinin, a typical Gq- and phospholipase Cβ-coupled GPCR, without any effect on its inositol 1,4,5-trisphosphate production. PCB19 reduced thapsigargin-induced sustained cytosolic Ca2+ levels, suggesting that PCB19 inhibits SOCE. The abilities of other NDL-PCBs to inhibit store-operated Ca2+ entry (SOCE were also examined and found to be of similar potencies to that of PCB19. PCB19 also showed a manner equivalent to that of known SOCE inhibitors. PCB19-mediated SOCE inhibition was confirmed by demonstrating the ability of PCB19 to inhibit the SOCE current and thapsigargin-induced Mn2+ influx. These results imply that one of the molecular mechanism by which NDL-PCBs cause neurobehavioral disturbances involves NDL-PCB-mediated inhibition of SOCE, thereby interfering with GPCR-mediated Ca2+ signaling.

  19. Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway

    Directory of Open Access Journals (Sweden)

    Freeman Robert S

    2011-02-01

    Full Text Available Abstract Background Thrombolytic therapy with tissue plasminogen activator (tPA benefits patients with acute ischemic stroke. However, tPA increases the risk for intracerebral bleeding and enhances post-ischemic neuronal injury if administered 3-4 hours after stroke. Therefore, combination therapies with tPA and neuroprotective agents have been considered to increase tPA's therapeutic window and reduce toxicity. The anticoagulant factor protein S (PS protects neurons from hypoxic/ischemic injury. PS also inhibits N-methyl-D-aspartate (NMDA excitotoxicity by phosphorylating Bad and Mdm2 which blocks the downstream steps in the intrinsic apoptotic cascade. To test whether PS can protect neurons from tPA toxicity we studied its effects on tPA/NMDA combined injury which in contrast to NMDA alone kills neurons by activating the extrinsic apoptotic pathway. Neither Bad nor Mdm2 which are PS's targets and control the intrinsic apoptotic pathway can influence the extrinsic cascade. Thus, based on published data one cannot predict whether PS can protect neurons from tPA/NMDA injury by blocking the extrinsic pathway. Neurons express all three TAM (Tyro3, Axl, Mer receptors that can potentially interact with PS. Therefore, we studied whether PS can activate TAM receptors during a tPA/NMDA insult. Results We show that PS protects neurons from tPA/NMDA-induced apoptosis by suppressing Fas-ligand (FasL production and FasL-dependent caspase-8 activation within the extrinsic apoptotic pathway. By transducing neurons with adenoviral vectors expressing the kinase-deficient Akt mutant AktK179A and a triple FKHRL1 Akt phosphorylation site mutant (FKHRL1-TM, we show that Akt activation and Akt-mediated phosphorylation of FKHRL1, a member of the Forkhead family of transcription factors, are critical for FasL down-regulation and caspase-8 inhibition. Using cultured neurons from Tyro3, Axl and Mer mutants, we show that Tyro3, but not Axl and Mer, mediates

  20. In vitro comparison rate of dental root canal transportation using two single file systems on the simulated resin blocks

    Directory of Open Access Journals (Sweden)

    Mohammad Javad Etesami

    2016-07-01

    Full Text Available Background and Aims: Cleaning and shaping is one of the most important stages in endodontic treatment. Single-file systems save time and reduce the risk of transmission of pathogens. This in vitro study was aimed to compare the rate of canal transportation after the preparation of the stimulated resin root canal with two single-file systems, namely Waveone and Reciproc. Materials and Methods: Thirty stimulated resin root canal blocks with size 8/0. 02 K file were randomly divided into two study groups. The preparation in Group A and Group B was performed using Reciproc and Waveone files, respectively. Pre and post- preparation photographs were taken and the images were superimposed to evaluate the inner and outer wall’s curvature tendency at three points (apical, middle and coronal using AutoCad pragram. Data were analyzed using T-test. Results: Based on the results, the degree of transportation in the inner and outer walls of the canal was less at the level of 3 millimeters (P0.05. Conclusion: Waveone showed better performance in the middle third of canal and this system maybe recommended.