WorldWideScience

Sample records for biophysconnector connecting sequence

  1. Detecting Emotions from Connected Action Sequences

    Science.gov (United States)

    Bernhardt, Daniel; Robinson, Peter

    In this paper we deal with the problem of detecting emotions from the body movements produced by naturally connected action sequences. Although action sequences are one of the most common forms of body motions in everyday scenarios their potential for emotion recognition has not been explored in the past. We show that there are fundamental differences between actions recorded in isolation and in natural sequences and demonstrate a number of techniques which allow us to correctly label action sequences with one of four emotions up to 86% of the time. Our results bring us an important step closer to recognizing emotions from body movements in natural scenarios.

  2. A Special Integer Sequence Strongly Connected to the Discrete Logarithm Problem

    Directory of Open Access Journals (Sweden)

    Omar Khadir

    2013-03-01

    Full Text Available Let p be a large prime integer. In this work, we study the recurrent sequence defined by ... and ... . This integer sequence has connection with the discrete logarithm problem, and under certain assumptions, we obtain an exact solution.

  3. A Special Integer Sequence Strongly Connected to the Discrete Logarithm Problem

    OpenAIRE

    Omar Khadir; Laszlo Szalay

    2013-01-01

    Let p be a large prime integer. In this work, we study the recurrent sequence defined by ... and ... . This integer sequence has connection with the discrete logarithm problem, and under certain assumptions, we obtain an exact solution.

  4. Cortico-cerebellar functional connectivity and sequencing of movements in schizophrenia

    Directory of Open Access Journals (Sweden)

    Kasparek Tomas

    2012-03-01

    Full Text Available Abstract Background Abnormal execution of several movements in a sequence is a frequent finding in schizophrenia. Successful performance of such motor acts requires correct integration of cortico-subcortical processes, particularly those related to cerebellar functions. Abnormal connectivity between cortical and cerebellar regions with resulting cognitive dysmetria has been proposed as the core dysfunction behind many signs and symptoms of schizophrenia. The aim of the present study was to assess if these proposed abnormalities in connectivity are a unifying feature of schizophrenia, or, rather, reflect a specific symptom domain of a heterogeneous disease. We predicted that abnormal functional connectivity between the motor cortex and cerebellum would be linked with abnormal performance of movement sequencing. Methods We examined 24 schizophrenia patients (SCH and 24 age-, sex-, and handedness-matched healthy controls (HC using fMRI during a modified finger-tapping task. The ability to perform movement sequencing was tested using the Neurological Evaluation Scale (NES. The subjects were categorized into two groups, with (SQ+ and without (SQ- movement sequencing abnormalities, according to the NES-SQ score. The effects of diagnosis and movement sequencing abnormalities on the functional connectivity parameters between the motor cortex and cerebellum (MC-CRBL and the supplementary motor cortex and cerebellum (SMA-CRBL activated during the motor task were analyzed. Results We found no effect of diagnosis on the functional connectivity measures. There was, however, a significant effect on the SQ group: SQ + patients showed a lower level of MC-CRBL connectivity than SQ- patients and healthy controls. Moreover, the level of MC-CRBL and SMA-CRBL negatively correlated with the magnitude of NES-SQ abnormalities, but with no other NES domain. Conclusions Abnormal cortico-cerebellar functional connectivity during the execution of a motor task is linked

  5. Use of hourly sequences of global radiation for simulation of photovoltaic systems grid connected

    Energy Technology Data Exchange (ETDEWEB)

    Sidrach de Cardona, M. [Dept. Fisica Aplicada 2, E.T.S.I., Univ. de Malaga (Spain); Mora Lopez, Ll. [Dept. Lenguajes y Ciencias de la Computacion, E.T.S.I., Univ. de Malaga (Spain)

    1996-12-31

    In this paper we analyse whether it is suitable to use hourly sequences of global radiation to study the performance of photovoltaic systems grid connected. The purpose of this paper is to quantify the error which is made on predicting the energy which a photovoltaic system connected to the grid, when the global radiation interval considered (which is an input value in our computations) varies. Using a simulation model we have studied how much energy is produced. The input values we considered are: values of daily global radiation, values of hourly global radiation and global radiation intervals of 10 minutes. These data have been recorded by the metereological station in Malaga of Andalusian Institute for renewable energies. In each interval, the simulation model takes into account the variations in module temperature as a function of ambient temperature. Therefore, when using daily values the model takes into account the average value of ambient temperature during sun hours and when using other values the model takes into account the average of this parameter in the interval under consideration. The nominal power considered is 2 kWp. The model we use assumes that the working point of the installation is always the maximum power point of modules and that all produced energy is injected in the grid. We also study the influence on this error when different set point of minimum input power for inverter starting (threshold value) are used. (orig.)

  6. A Note on Stability of a Linear Functional Equation of Second Order Connected with the Fibonacci Numbers and Lucas Sequences

    Directory of Open Access Journals (Sweden)

    Janusz Brzdęk

    2010-01-01

    Full Text Available We prove the Hyers-Ulam stability of a second-order linear functional equation in single variable (with constant coefficients that is connected with the Fibonacci numbers and Lucas sequences. In this way we complement, extend, and/or improve some recently published results on stability of that equation.

  7. Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi

    OpenAIRE

    Cacho, Ralph A.; Yi eTang; Yit-Heng eChooi

    2015-01-01

    Genomics has revolutionized the research on fungal secondary metabolite biosynthesis. To elucidate the molecular and enzymatic mechanisms underlying the biosynthesis of a specific secondary metabolite compound, the important first step is often to find the genes that responsible for its synthesis. The accessibility to fungal genome sequences allows the bypass of the cumbersome traditional library construction and screening approach. The advance in next-generation sequencing (NGS) technologies...

  8. Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi

    OpenAIRE

    Cacho, Ralph A.; Tang, Yi; Chooi, Yit-Heng

    2015-01-01

    Genomics has revolutionized the research on fungal secondary metabolite (SM) biosynthesis. To elucidate the molecular and enzymatic mechanisms underlying the biosynthesis of a specific SM compound, the important first step is often to find the genes that responsible for its synthesis. The accessibility to fungal genome sequences allows the bypass of the cumbersome traditional library construction and screening approach. The advance in next-generation sequencing (NGS) technologies have further...

  9. Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi

    Directory of Open Access Journals (Sweden)

    Ralph A Cacho

    2015-01-01

    Full Text Available Genomics has revolutionized the research on fungal secondary metabolite biosynthesis. To elucidate the molecular and enzymatic mechanisms underlying the biosynthesis of a specific secondary metabolite compound, the important first step is often to find the genes that responsible for its synthesis. The accessibility to fungal genome sequences allows the bypass of the cumbersome traditional library construction and screening approach. The advance in next-generation sequencing (NGS technologies have further improved the speed and reduced the cost of microbial genome sequencing in the past few years, which has accelerated the research in this field. Here, we will present an example work flow for identifying the gene cluster encoding the biosynthesis of secondary metabolites of interest using an NGS approach. We will also review the different strategies that can be employed to pinpoint the targeted gene clusters rapidly by giving several examples stemming from our work.

  10. Effects of Particle Size, Electronic Connectivity, and Incoherent Nanoscale Domains on the Sequence of Lithiation in LiFePO₄ Porous Electrodes.

    Science.gov (United States)

    Li, Yiyang; Meyer, Sophie; Lim, Jongwoo; Lee, Sang Chul; Gent, William E; Marchesini, Stefano; Krishnan, Harinarayan; Tyliszczak, Tolek; Shapiro, David; Kilcoyne, Arthur L David; Chueh, William C

    2015-11-01

    High-resolution X-ray microscopy is used to investigate the sequence of lithiation in LiFePO4 porous electrodes. For electrodes with homogeneous interparticle electronic connectivity via the carbon black network, the smaller particles lithiate first. For electrodes with heterogeneous connectivity, the better-connected particles preferentially lithiate. Correlative electron and X-ray microscopy also reveal the presence of incoherent nanodomains that lithiate as if they are separate particles. PMID:26423560

  11. INVESTIGATING CONNECTIONS BETWEEN SOME SMARANDACHE SEQUENCES, PRIME NUMBERS AND MAGIC SQUARES

    OpenAIRE

    CHEBRAKOV, Y.V.; SHMAGIN, V.V.

    2010-01-01

    In this paper we investigate some properties of Smarandache sequences of the 2nd kind and demonstrate that these numbers are near prime numbers. In particular, we establish that prime numbers and Smarandache numbers of the 2nd kind (a) may be computed from the similar analytical expressions, (b) may be used for constructing Magic squares 3x3 or Magic squares 9x9, consisted of 9 Magic squares 3x3.

  12. Local amino acid sequence patterns dominate the heterogeneous phenotype for the collagen connective tissue disease Osteogenesis Imperfecta resulting from Gly mutations.

    Science.gov (United States)

    Xiao, Jianxi; Yang, Zhangfu; Sun, Xiuxia; Addabbo, Rayna; Baum, Jean

    2015-10-01

    Osteogenesis Imperfecta (OI), a hereditary connective tissue disease in collagen that arises from a single Gly → X mutation in the collagen chain, varies widely in phenotype from perinatal lethal to mild. It is unclear why there is such a large variation in the severity of the disease considering the repeating (Gly-X-Y)n sequence and the uniform rod-like structure of collagen. We systematically evaluate the effect of local (Gly-X-Y)n sequence around the mutation site on OI phenotype using integrated bio-statistical approaches, including odds ratio analysis and decision tree modeling. We show that different Gly → X mutations have different local sequence patterns that are correlated with lethal and nonlethal phenotypes providing a mechanism for understanding the sensitivity of local context in defining lethal and non-lethal OI. A number of important trends about which factors are related to OI phenotypes are revealed by the bio-statistical analyses; most striking is the complementary relationship between the placement of Pro residues and small residues and their correlation to OI phenotype. When Pro is present or small flexible residues are absent nearby a mutation site, the OI case tends to be lethal; when Pro is present or small flexible residues are absent further away from the mutation site, the OI case tends to be nonlethal. The analysis also reveals the dominant role of local sequence around mutation sites in the Major Ligand Binding Regions that are primarily responsible for collagen binding to its receptors and shows that non-lethal mutations are highly predicted by local sequence considerations alone whereas lethal mutations are not as easily predicted and may be a result of more complex interactions. Understanding the sequence determinants of OI mutations will enhance genetic counseling and help establish which steps in the collagen hierarchy to target for drug therapy.

  13. Connecting Local Environmental Sequences to Global Climate Patterns: Evidence From the Hominin-Bearing Hadar Formation, Ethiopia.

    Science.gov (United States)

    Campisano, C. J.; Feibel, C. S.

    2004-12-01

    Central to the debate surrounding global climate change and Plio-Pleistocene hominin evolution is the degree to which large-scale climate patterns influence low-latitude continental ecosystems and how these global influences can be distinguished from regional tectono-volcanic events and local environmental effects. These isolated factors must then be compared to trends or events in the hominin fossil or archaeological record. The Pliocene Hadar Formation preserves a high-resolution record of hominin paleoenvironments from roughly 3.5 to 2.3 Ma. The chronostratigraphic framework at Hadar, often divisible into sub-50,000 year intervals, provides temporal resolution relevant to evolutionary change within hominins and other taxa. Combined with a high sedimentation rate and abundant faunal remains, this tightly controlled stratigraphic framework allows Hadar to be compared to detailed climate proxies such as marine core isotope, dust, and sapropel records. Preliminary analyses from Hadar suggest that these comparisons can be used to distinguish local versus regional and global environmental change, determine the overall sensitivity of the Hadar system and its fauna to such change, and how this level of sensitively compares to other East African localities. Consistent cycling observed both between and within fluvial and lacustrine depositional environments prior to 2.9 Ma at Hadar appears to be dominantly climatic in nature. However, a significant change in depositional facies after 2.9 Ma to sequences dominated by conglomerate cut-and-fill cycles indicates a strong tectonic signature related to regional developments in the Main Ethiopian Rift (MER). While specific events seen in marine proxy records may have parallels in the Hadar environmental archive, their overall patterns of high versus low variability may be even more relevant. For example, periods of relatively high amplitude climate oscillations between 3.15 and 2.95 Ma may be linked to noted morphological

  14. Assessing hydraulic connections across a complex sequence of volcanic rocks - Analysis of U-20 WW multiple-well aquifer test, Pahute Mesa, Nevada National Security Site, Nevada

    Science.gov (United States)

    Garcia, C. Amanda; Fenelon, Joseph M.; Halford, Keith J.; Reiner, Steven R.; Laczniak, Randell J.

    2011-01-01

    Groundwater beneath Pahute Mesa flows through a complexly layered sequence of volcanic rock aquifers and confining units that have been faulted into distinct structural blocks. Hydraulic property estimates of rocks and structures in this flow system are necessary to assess radionuclide migration near underground nuclear testing areas. The U.S. Geological Survey (USGS) used a 12 month (October 1, 2008— October 1, 2009) intermittent pumping schedule of well U-20 WW and continuously monitored water levels in observation wells ER-20-6 #3, UE-20bh 1, and U-20bg as a multi-well aquifer test to evaluate hydraulic connections across structural blocks, bulk hydraulic properties of volcanic rocks, and the hydraulic significance of a major fault. Measured water levels were approximated using synthetic water levels generated from an analytical model. Synthetic water levels are a summation of environmental water-level fluctuations and a Theis (1935) transform of the pumping signal from flow rate to water-level change. Drawdown was estimated by summing residual differences between measured and synthetic water levels and the Theis-transformed pumping signal from April to September 2009. Drawdown estimates were used in a three‑dimensional numerical model to estimate hydraulic properties of distinct aquifers, confining units, and a major fault.

  15. Fibonacci-Like Sequence

    OpenAIRE

    Shikha Bhatnagar; Bijendra Singh; Omprakash Sikhwal

    2013-01-01

    The Fibonacci and Lucas sequences are well-known examples of second order recurrence sequences, which belong to particular class of recursive sequences. In this article, Fibonacci-Like sequence is introduced and defined by The Binet’s formula and generating function of Fibonacci-Like sequence are presented with some identities and connection formulae.

  16. A Brief Analysis on sequence of clauses of Compound Sentences without Connective s in Russian%俄语无连接词复合句的分句间次序浅析

    Institute of Scientific and Technical Information of China (English)

    孔韶辉

    2005-01-01

    各分句间不用连接词或关联词,而用语调;标点符号等手段连接起来的复合句叫无连接词复合句.无连接词复合句具有意义含蓄,结构紧凑,用词简练,形式活泼等特点,是一个争议颇多,难以掌握的句法结构,这里着重论述无连接词复合句的分句次序.%Compound sentences which do not connect with each other between their clauses by intonation, punctuation mark and so on, are compound sentences without connectives. These compound sentences, characterized by meaningful implication, close structure, concise vocabulary, active form, etc. are a controversial and difficult syntactical structure. This paper focuses on the sequence of clauses of compound sentences without connectives.

  17. Connected Traveler

    Energy Technology Data Exchange (ETDEWEB)

    Schroeder, Alex

    2015-11-01

    The Connected Traveler project is a multi-disciplinary undertaking that seeks to validate potential for transformative transportation system energy savings by incentivizing efficient traveler behavior. This poster outlines various aspects of the Connected Traveler project, including market opportunity, understanding traveler behavior and decision-making, automation and connectivity, and a projected timeline for Connected Traveler's key milestones.

  18. A Tale of Two Anomalies: Depletion, Dispersion, and the Connection Between the Stellar Lithium Spread and Inflated Radii on the Pre-Main Sequence

    CERN Document Server

    Somers, Garrett

    2014-01-01

    We investigate lithium depletion in standard stellar models (SSMs) and main sequence (MS) open clusters, and explore the origin of the Li dispersion in young, cool stars of equal mass, age and composition. We first demonstrate that SSMs accurately predict the Li abundances of solar analogs at the zero-age main sequence (ZAMS) within theoretical uncertainties. We then measure the rate of MS Li depletion by removing the [Fe/H]-dependent ZAMS Li pattern from three well-studied clusters, and comparing the detrended data. MS depletion is found to be mass dependent, in the sense of more depletion at low mass. A dispersion in Li abundance at fixed $T_{\\rm eff}$ is nearly universal, and sets in by $\\sim$200 Myr. We discuss mass and age dispersion trends, and the pattern is mixed. We argue that metallicity impacts the ZAMS Li pattern, in agreement with theoretical expectations but contrary to the findings of some previous studies, and suggest Li as a test of cluster metallicity. Finally, we argue that a radius dispers...

  19. A Tale of Two Anomalies: Depletion, Dispersion, and the Connection between the Stellar Lithium Spread and Inflated Radii on the Pre-main Sequence

    Science.gov (United States)

    Somers, Garrett; Pinsonneault, Marc H.

    2014-07-01

    We investigate lithium depletion in standard stellar models (SSMs) and main sequence (MS) open clusters, and explore the origin of the Li dispersion in young, cool stars of equal mass, age, and composition. We first demonstrate that SSMs accurately predict the Li abundances of solar analogs at the zero-age main sequence (ZAMS) within theoretical uncertainties. We then measure the rate of MS Li depletion by removing the [Fe/H]-dependent ZAMS Li pattern from three well-studied clusters, and comparing the detrended data. MS depletion is found to be mass-dependent, in the sense of more depletion at low mass. A dispersion in Li abundance at fixed T eff is nearly universal, and sets in by ~200 Myr. We discuss mass and age dispersion trends, and the pattern is mixed. We argue that metallicity impacts the ZAMS Li pattern, in agreement with theoretical expectations but contrary to the findings of some previous studies, and suggest Li as a test of cluster metallicity. Finally, we argue that a radius dispersion in stars of fixed mass and age, during the epoch of pre-MS Li destruction, is responsible for the spread in Li abundances and the correlation between rotation and Li in young cool stars, most well known in the Pleiades. We calculate stellar models, inflated to match observed radius anomalies in magnetically active systems, and the resulting range of Li abundances reproduces the observed patterns of young clusters. We discuss ramifications for pre-MS evolutionary tracks and age measurements of young clusters, and suggest an observational test.

  20. A tale of two anomalies: Depletion, dispersion, and the connection between the stellar lithium spread and inflated radii on the pre-main sequence

    Energy Technology Data Exchange (ETDEWEB)

    Somers, Garrett; Pinsonneault, Marc H., E-mail: somers@astronomy.ohio-state.edu, E-mail: pinsono@astronomy.ohio-state.edu [Department of Astronomy, The Ohio State University, 140 West 18th Avenue, Columbus, OH 43201 (United States)

    2014-07-20

    We investigate lithium depletion in standard stellar models (SSMs) and main sequence (MS) open clusters, and explore the origin of the Li dispersion in young, cool stars of equal mass, age, and composition. We first demonstrate that SSMs accurately predict the Li abundances of solar analogs at the zero-age main sequence (ZAMS) within theoretical uncertainties. We then measure the rate of MS Li depletion by removing the [Fe/H]-dependent ZAMS Li pattern from three well-studied clusters, and comparing the detrended data. MS depletion is found to be mass-dependent, in the sense of more depletion at low mass. A dispersion in Li abundance at fixed T{sub eff} is nearly universal, and sets in by ∼200 Myr. We discuss mass and age dispersion trends, and the pattern is mixed. We argue that metallicity impacts the ZAMS Li pattern, in agreement with theoretical expectations but contrary to the findings of some previous studies, and suggest Li as a test of cluster metallicity. Finally, we argue that a radius dispersion in stars of fixed mass and age, during the epoch of pre-MS Li destruction, is responsible for the spread in Li abundances and the correlation between rotation and Li in young cool stars, most well known in the Pleiades. We calculate stellar models, inflated to match observed radius anomalies in magnetically active systems, and the resulting range of Li abundances reproduces the observed patterns of young clusters. We discuss ramifications for pre-MS evolutionary tracks and age measurements of young clusters, and suggest an observational test.

  1. Sequence information signal processor

    Science.gov (United States)

    Peterson, John C.; Chow, Edward T.; Waterman, Michael S.; Hunkapillar, Timothy J.

    1999-01-01

    An electronic circuit is used to compare two sequences, such as genetic sequences, to determine which alignment of the sequences produces the greatest similarity. The circuit includes a linear array of series-connected processors, each of which stores a single element from one of the sequences and compares that element with each successive element in the other sequence. For each comparison, the processor generates a scoring parameter that indicates which segment ending at those two elements produces the greatest degree of similarity between the sequences. The processor uses the scoring parameter to generate a similar scoring parameter for a comparison between the stored element and the next successive element from the other sequence. The processor also delivers the scoring parameter to the next processor in the array for use in generating a similar scoring parameter for another pair of elements. The electronic circuit determines which processor and alignment of the sequences produce the scoring parameter with the highest value.

  2. Gendered Connections

    DEFF Research Database (Denmark)

    Jensen, Steffen Bo

    2009-01-01

    This article explores the gendered nature of urban politics in Cape Town by focusing on a group of female, township politicians. Employing the Deleuzian concept of `wild connectivity', it argues that these politically entrepreneurial women were able to negotiate a highly volatile urban landscape ...... of connectivity might endure, as Capetonian politics assumes a post-apartheid structure....

  3. About Connections

    Directory of Open Access Journals (Sweden)

    Kathleen S Rockland

    2015-05-01

    Full Text Available Despite the attention attracted by connectomics, one can lose sight of the very real questions concerning What are connections? In the neuroimaging community, structural connectivity is ground truth and underlying constraint on functional or effective connectivity. It is referenced to underlying anatomy; but, as increasingly remarked, there is a large gap between the wealth of human brain mapping and the relatively scant data on actual anatomical connectivity. Moreover, connections have typically been discussed as pairwise, point x projecting to point y (or: to points y and z, or more recently, in graph theoretical terms, as nodes or regions and the interconnecting edges. This is a convenient shorthand, but tends not to capture the richness and nuance of basic anatomical properties as identified in the classic tradition of tracer studies. The present short review accordingly revisits connectional weights, heterogeneity, reciprocity, topography, and hierarchical organization, drawing on concrete examples. The emphasis is on presynaptic long-distance connections, motivated by the intention to probe current assumptions and promote discussions about further progress and synthesis.

  4. HR Connect

    Data.gov (United States)

    US Agency for International Development — HR Connect is the USAID HR personnel system which allows HR professionals to process HR actions related to employee's personal and position information. This system...

  5. Pythagorean Triples from Harmonic Sequences.

    Science.gov (United States)

    DiDomenico, Angelo S.; Tanner, Randy J.

    2001-01-01

    Shows how all primitive Pythagorean triples can be generated from harmonic sequences. Use inductive and deductive reasoning to explore how Pythagorean triples are connected with another area of mathematics. (KHR)

  6. Connected Traveler

    Energy Technology Data Exchange (ETDEWEB)

    2016-06-01

    The Connected Traveler framework seeks to boost the energy efficiency of personal travel and the overall transportation system by maximizing the accuracy of predicted traveler behavior in response to real-time feedback and incentives. It is anticipated that this approach will establish a feedback loop that 'learns' traveler preferences and customizes incentives to meet or exceed energy efficiency targets by empowering individual travelers with information needed to make energy-efficient choices and reducing the complexity required to validate transportation system energy savings. This handout provides an overview of NREL's Connected Traveler project, including graphics, milestones, and contact information.

  7. DISULFIND: A DISULFIDE BONDING STATE AND CYSTEINE CONNECTIVITY PREDICTION SERVER

    OpenAIRE

    Ceroni, A; Passerini, A.; Vullo,A; Frasconi, P.

    2006-01-01

    DISULFIND is a server for predicting the disulfide bonding state of cysteines and their disulfide connectivity starting from sequence alone. Optionally, disulfide connectivity can be predicted from sequence and a bonding state assignment given as input. The output is a simple visualization of the assigned bonding state (with confidence degrees) and the most likely connectivity patterns. The server is available at .

  8. 78 FR 55684 - ConnectED Workshop

    Science.gov (United States)

    2013-09-11

    ... National Telecommunications and Information Administration ConnectED Workshop AGENCY: National... in the United States to next- generation broadband. This Notice announces that the ConnectED Workshop... ConnectED Workshop will discuss the growing bandwidth needs of K-12 schools as more schools use...

  9. Application of difference sequences theory

    OpenAIRE

    Khantarzhiev, Georgii

    2013-01-01

    The results of difference sequences theory are applied to analytic function theory and Diophantine equations. As a result we have the equation which connects the $n$-th derivative of a function with the difference sequence for the values of this function. Also the results of difference sequences theory helps to discover some features of the whole kind of Diophantine equations. The method presented allows to find limits where Diophantine equation does not have integer solutions. The higher pow...

  10. Discordant connections

    OpenAIRE

    Arora-Jonsson, Seema

    2009-01-01

    The importance of gender-equality and of women’s work in relation to the environment are considered to be crucial questions for development in ‘third world’ rural societies. ‘Development’ and a certain standard of welfare make these issues appear to be less urgent in a wealthier country like Sweden. In this paper I trace some of the contradictions and connections in the ways in which gender equality is conceptualised in women’s struggles vis á vis environmental issues in rural areas in Swede...

  11. Automatic sequences

    CERN Document Server

    Haeseler, Friedrich

    2003-01-01

    Automatic sequences are sequences which are produced by a finite automaton. Although they are not random they may look as being random. They are complicated, in the sense of not being not ultimately periodic, they may look rather complicated, in the sense that it may not be easy to name the rule by which the sequence is generated, however there exists a rule which generates the sequence. The concept automatic sequences has special applications in algebra, number theory, finite automata and formal languages, combinatorics on words. The text deals with different aspects of automatic sequences, in particular:· a general introduction to automatic sequences· the basic (combinatorial) properties of automatic sequences· the algebraic approach to automatic sequences· geometric objects related to automatic sequences.

  12. Controlled processing during sequencing.

    Science.gov (United States)

    Thothathiri, Malathi; Rattinger, Michelle

    2015-01-01

    Longstanding evidence has identified a role for the frontal cortex in sequencing within both linguistic and non-linguistic domains. More recently, neuropsychological studies have suggested a specific role for the left premotor-prefrontal junction (BA 44/6) in selection between competing alternatives during sequencing. In this study, we used neuroimaging with healthy adults to confirm and extend knowledge about the neural correlates of sequencing. Participants reproduced visually presented sequences of syllables and words using manual button presses. Items in the sequence were presented either consecutively or concurrently. Concurrent presentation is known to trigger the planning of multiple responses, which might compete with one another. Therefore, we hypothesized that regions involved in controlled processing would show greater recruitment during the concurrent than the consecutive condition. Whole-brain analysis showed concurrent > consecutive activation in sensory, motor and somatosensory cortices and notably also in rostral-dorsal anterior cingulate cortex. Region of interest analyses showed increased activation within left BA 44/6 and correlation between this region's activation and behavioral response times. Functional connectivity analysis revealed increased connectivity between left BA 44/6 and the posterior lobe of the cerebellum during the concurrent than the consecutive condition. These results corroborate recent evidence and demonstrate the involvement of BA 44/6 and other control regions when ordering co-activated representations.

  13. Controlled processing during sequencing

    Directory of Open Access Journals (Sweden)

    Malathi eThothathiri

    2015-10-01

    Full Text Available Longstanding evidence has identified a role for the frontal cortex in sequencing within both linguistic and non-linguistic domains. More recently, neuropsychological studies have suggested a specific role for the left premotor-prefrontal junction (BA 44/6 in selection between competing alternatives during sequencing. In this study, we used neuroimaging with healthy adults to confirm and extend knowledge about the neural correlates of sequencing. Participants reproduced visually presented sequences of syllables and words using manual button presses. Items in the sequence were presented either consecutively or concurrently. Concurrent presentation is known to trigger the planning of multiple responses, which might compete with one another. Therefore, we hypothesized that regions involved in controlled processing would show greater recruitment during the concurrent than the consecutive condition. Whole-brain analysis showed concurrent > consecutive activation in sensory, motor and somatosensory cortices and notably also in rostral-dorsal anterior cingulate cortex (ACC. Region of interest analyses showed increased activation within left BA 44/6 and correlation between this region’s activation and behavioral response times. Functional connectivity analysis revealed increased connectivity between left BA 44/6 and the posterior lobe of the cerebellum during the concurrent than the consecutive condition. These results corroborate recent evidence and demonstrate the involvement of BA 44/6 and other control regions when ordering co-activated representations.

  14. Places Connected:

    DEFF Research Database (Denmark)

    Hansen, Annette Skovsted

    Nations Volunteer of Japanese nationality. Networks of personal ties, ideas, feelings, and material culture. By combining work on the experience of place with network historiography on migration and kinship, the paper presents a case on the function of the temporary encounter in human networks....... experience the places of Denmark and Japan temporarily integrate the national histories of these two countries in the histories of their home countries and vice versa. Thereby, I wish to offer a dynamic understanding of development history and globalization, which challenges the nationally bound histories...... experiences of place, however, when it is often the same people who experience many different places? Along with many other so-called donors in the 1950s, Denmark and Japan chose to invest in the education of own and other nationals involved in development and thereby financed personal connections between...

  15. Genome Sequencing

    DEFF Research Database (Denmark)

    Sato, Shusei; Andersen, Stig Uggerhøj

    2014-01-01

    The current Lotus japonicus reference genome sequence is based on a hybrid assembly of Sanger TAC/BAC, Sanger shotgun and Illumina shotgun sequencing data generated from the Miyakojima-MG20 accession. It covers nearly all expressed L. japonicus genes and has been annotated mainly based on transcr......The current Lotus japonicus reference genome sequence is based on a hybrid assembly of Sanger TAC/BAC, Sanger shotgun and Illumina shotgun sequencing data generated from the Miyakojima-MG20 accession. It covers nearly all expressed L. japonicus genes and has been annotated mainly based...

  16. Connection Strings Property on ADO Connection Object

    Institute of Scientific and Technical Information of China (English)

    Girigi Deogratias; Wu Min; Cao Weihua

    2002-01-01

    The connection string property on ADO connection object contains the information used to establish a connection to the data source. The syntax, the keyword of that information must be in specific format. Depending on the type of data you are connecting to, you need either specify an OLEDB provider or use on ODBC driver. The biggest problem, the industries face is the proliferation of data access interfaces, and the complexity of creating,maintaining and programming against them, and the network problem when communicating over the Intranet or the Internet. This paper first provides an in-depth look of the standard arguments supported by ADO connection string; then gives the easier way for understanding the meaning, the utility and the syntax of the connection strings property on ADO connection object, and finally proposes solution to work around the problems due to the connection strings errors.

  17. Attribute-space connectivity and connected filters

    NARCIS (Netherlands)

    Wilkinson, Michael H.F.

    2007-01-01

    In this paper connected operators from mathematical morphology are extended to a wider class of operators, which are based on connectivities in higher dimensional spaces, similar to scale spaces, which will be called attribute-spaces. Though some properties of connected filters are lost, granulometr

  18. Sequence assembly

    DEFF Research Database (Denmark)

    Scheibye-Alsing, Karsten; Hoffmann, S.; Frankel, Annett Maria;

    2009-01-01

    and plays an important role in processing the information generated by these methods. Here, we provide a comprehensive overview of the current publicly available sequence assembly programs. We describe the basic principles of computational assembly along with the main concerns, such as repetitive sequences...

  19. Sequence-structure relations of biopolymers

    CERN Document Server

    Barrett, Christopher; Reidys, Christian M

    2015-01-01

    Motivation: DNA data is transcribed into single-stranded RNA, which folds into specific molecular structures. In this paper we pose the question to what extent sequence- and structure-information correlate. We view this correlation as structural semantics of sequence data that allows for a different interpretation than conventional sequence alignment. Structural semantics could enable us to identify more general embedded "patterns" in DNA and RNA sequences. Results: We compute the partition function of sequences with respect to a fixed structure and connect this computation to the mutual information of a sequence-structure pair for RNA secondary structures. We present a Boltzmann sampler and obtain the a priori probability of specific sequence patterns. We present a detailed analysis for the three PDB-structures, 2JXV (hairpin), 2N3R (3-branch multi-loop) and 1EHZ (tRNA). We localize specific sequence patterns, contrast the energy spectrum of the Boltzmann sampled sequences versus those sequences that refold ...

  20. Dna Sequencing

    Science.gov (United States)

    Tabor, Stanley; Richardson, Charles C.

    1995-04-25

    A method for sequencing a strand of DNA, including the steps off: providing the strand of DNA; annealing the strand with a primer able to hybridize to the strand to give an annealed mixture; incubating the mixture with four deoxyribonucleoside triphosphates, a DNA polymerase, and at least three deoxyribonucleoside triphosphates in different amounts, under conditions in favoring primer extension to form nucleic acid fragments complementory to the DNA to be sequenced; labelling the nucleic and fragments; separating them and determining the position of the deoxyribonucleoside triphosphates by differences in the intensity of the labels, thereby to determine the DNA sequence.

  1. Minimum cost connection networks

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Tvede, Mich

    . We use three axioms to characterize allocation rules that truthfully implement cost minimizing networks satisfying all connection demands in a game where: (1) a central planner announces an allocation rule and a cost estimation rule; (2) every agent reports her own connection demand as well as all...... connection costs; and, (3) the central planner selects a cost minimizing network satisfying reported connection demands based on estimated connection costs and allocates true connection costs of the selected network.......In the present paper we consider the allocation of cost in connection networks. Agents have connection demands in form of pairs of locations they want to be connected. Connections between locations are costly to build. The problem is to allocate costs of networks satisfying all connection demands...

  2. Minimum cost connection networks

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Tvede, Mich

    2015-01-01

    demands. We use a few axioms to characterize allocation rules that truthfully implement cost minimizing networks satisfying all connection demands in a game where: (1) a central planner announces an allocation rule and a cost estimation rule; (2) every agent reports her own connection demand as well...... as all connection costs; (3) the central planner selects a cost minimizing network satisfying reported connection demands based on the estimated costs; and, (4) the planner allocates the true costs of the selected network. It turns out that an allocation rule satisfies the axioms if and only if relative......In the present paper we consider the allocation of costs in connection networks. Agents have connection demands in form of pairs of locations they want to have connected. Connections between locations are costly to build. The problem is to allocate costs of networks satisfying all connection...

  3. Main: Sequences [KOME

    Lifescience Database Archive (English)

    Full Text Available Sequences Nucleotide Sequence Nucleotide sequence of full length cDNA (trimmed sequence) kome_ine_full_seque...nce_db.fasta.zip kome_ine_full_sequence_db.zip kome_ine_full_sequence_db ...

  4. [Sequencing babies?].

    Science.gov (United States)

    Jordan, Bertrand

    2015-10-01

    An extension of newborn screening to genome sequencing is now feasible but raises a number of scientific, organisational and ethical issues. This is being explored in discussions and in several funded trials, in order to maximize benefits and avoid some identified risks. As some companies are already offering such a service, this is quite an urgent matter. PMID:26481033

  5. One Dimensional Locally Connected S-spaces

    CERN Document Server

    Kunen, Joan E Hart Kenneth

    2007-01-01

    We construct, assuming Jensen's principle diamond, a one-dimensional locally connected hereditarily separable continuum without convergent sequences. The construction is an inverse limit in omega_1 steps, and is patterned after the original Fedorchuk construction of a compact S-space. To make it one-dimensional, each space in the inverse limit is a copy of the Menger sponge.

  6. MedlinePlus Connect

    Science.gov (United States)

    ... IT systems, patient portals and electronic health record (EHR) systems to relevant, authoritative patient health information from ... they need it via their patient portal or EHR. How does MedlinePlus Connect work? MedlinePlus Connect responds ...

  7. Galois connections and applications

    CERN Document Server

    Erné, M; Wismath, S

    2004-01-01

    This book presents the main ideas of General Galois Theory as a generalization of Classical Galois Theory It sketches the development of Galois connections through the last three centuries Examples of Galois connections as powerful tools in Category Theory and Universal Algebra are given Applications of Galois connections in Linguistic and Data Analysis are presented

  8. Asymptotically hyperbolic connections

    CERN Document Server

    Fine, Joel; Krasnov, Kirill; Scarinci, Carlos

    2015-01-01

    General Relativity in 4 dimensions can be equivalently described as a dynamical theory of SO(3)-connections rather than metrics. We introduce the notion of asymptotically hyperbolic connections, and work out an analog of the Fefferman-Graham expansion in the language of connections. As in the metric setup, one can solve the arising "evolution" equations order by order in the expansion in powers of the radial coordinate. The solution in the connection setting is arguably simpler, and very straightforward algebraic manipulations allow one to see how the obstruction appears at third order in the expansion. Another interesting feature of the connection formulation is that the "counter terms" required in the computation of the renormalised volume all combine into the Chern-Simons functional of the restriction of the connection to the boundary. As the Chern-Simons invariant is only defined modulo large gauge transformations, the requirement that the path integral over asymptotically hyperbolic connections is well-d...

  9. From Sequence to Morphology - Long-Range Correlations in Complete Sequenced Genomes

    NARCIS (Netherlands)

    T.A. Knoch (Tobias)

    2004-01-01

    textabstractThe largely unresolved sequential organization, i.e. the relations within DNA sequences, and its connection to the three-dimensional organization of genomes was investigated by correlation analyses of completely sequenced chromosomes from Viroids, Archaea, Bacteria, Arabidopsis thali

  10. Recurrent Network Models of Sequence Generation and Memory.

    Science.gov (United States)

    Rajan, Kanaka; Harvey, Christopher D; Tank, David W

    2016-04-01

    Sequential activation of neurons is a common feature of network activity during a variety of behaviors, including working memory and decision making. Previous network models for sequences and memory emphasized specialized architectures in which a principled mechanism is pre-wired into their connectivity. Here we demonstrate that, starting from random connectivity and modifying a small fraction of connections, a largely disordered recurrent network can produce sequences and implement working memory efficiently. We use this process, called Partial In-Network Training (PINning), to model and match cellular resolution imaging data from the posterior parietal cortex during a virtual memory-guided two-alternative forced-choice task. Analysis of the connectivity reveals that sequences propagate by the cooperation between recurrent synaptic interactions and external inputs, rather than through feedforward or asymmetric connections. Together our results suggest that neural sequences may emerge through learning from largely unstructured network architectures.

  11. Handbook of networking & connectivity

    CERN Document Server

    McClain, Gary R

    1994-01-01

    Handbook of Networking & Connectivity focuses on connectivity standards in use, including hardware and software options. The book serves as a guide for solving specific problems that arise in designing and maintaining organizational networks.The selection first tackles open systems interconnection, guide to digital communications, and implementing TCP/IP in an SNA environment. Discussions focus on elimination of the SNA backbone, routing SNA over internets, connectionless versus connection-oriented networks, internet concepts, application program interfaces, basic principles of layering, proto

  12. Asymptotically hyperbolic connections

    Science.gov (United States)

    Fine, Joel; Herfray, Yannick; Krasnov, Kirill; Scarinci, Carlos

    2016-09-01

    General relativity in four-dimensions can be equivalently described as a dynamical theory of {SO}(3)˜ {SU}(2)-connections rather than metrics. We introduce the notion of asymptotically hyperbolic connections, and work out an analogue of the Fefferman-Graham expansion in the language of connections. As in the metric setup, one can solve the arising ‘evolution’ equations order by order in the expansion in powers of the radial coordinate. The solution in the connection setting is arguably simpler, and very straightforward algebraic manipulations allow one to see how the unconstrained by Einstein equations ‘stress-energy tensor’ appears at third order in the expansion. Another interesting feature of the connection formulation is that the ‘counter terms’ required in the computation of the renormalised volume all combine into the Chern-Simons functional of the restriction of the connection to the boundary. As the Chern-Simons invariant is only defined modulo large gauge transformations, the requirement that the path integral over asymptotically hyperbolic connections is well-defined requires the cosmological constant to be quantised. Finally, in the connection setting one can deform the 4D Einstein condition in an interesting way, and we show that asymptotically hyperbolic connection expansion is universal and valid for any of the deformed theories.

  13. Inverse Degree and Connectivity

    Institute of Scientific and Technical Information of China (English)

    MA Xiao-ling; TIAN Ying-zhi

    2013-01-01

    Let G be a connected graph with vertex set V(G),order n =丨V(G)丨,minimum degree δ(G) and connectivity κ(G).The graph G is called maximally connected if κ(G) =δ(G).Define the inverse degree of G with no isolated vertices as R(G) =Σv∈V(G)1/d(v),where d(v) denotes the degree of the vertex v.We show that G is maximally connected if R(G) < 1 + 2/δ + n-2δ+1/(n-1)(n-3).

  14. A cooperative approach to sequencing and connection problems

    NARCIS (Netherlands)

    Ciftci, B.B.

    2009-01-01

    There are many economic settings in which a group of agents wishes to undertake a joint enterprise in order to save costs. The success of such enterprises often relies on agreements on how to share the cost savings generated. The central issue of this monograph is to address cost allocation problems

  15. Tokens of Connection

    Science.gov (United States)

    Crowley, Theresa

    2016-01-01

    When teachers make the effort to build a solid relationship with each student, built on trust, they often engender a life-long connection, one that's life-changing for the student. But how can teachers grow such long-lasting relationships with all students, especially disenfranchised learners and those who make it hard to connect? Crowley, a…

  16. Generalised Connections and Curvature

    OpenAIRE

    Kunzinger, Michael; Steinbauer, Roland; Vickers, James A.

    2004-01-01

    The concept of generalised (in the sense of Colombeau) connection on a principal fibre bundle is introduced. This definition is then used to extend results concerning the geometry of principal fibre bundles to those that only have a generalised connection. Some applications to singular solutions of Yang-Mills theory are given.

  17. Generalized connectivity of graphs

    CERN Document Server

    Li, Xueliang

    2016-01-01

    Noteworthy results, proof techniques, open problems and conjectures in generalized (edge-) connectivity are discussed in this book. Both theoretical and practical analyses for generalized (edge-) connectivity of graphs are provided. Topics covered in this book include: generalized (edge-) connectivity of graph classes, algorithms, computational complexity, sharp bounds, Nordhaus-Gaddum-type results, maximum generalized local connectivity, extremal problems, random graphs, multigraphs, relations with the Steiner tree packing problem and generalizations of connectivity. This book enables graduate students to understand and master a segment of graph theory and combinatorial optimization. Researchers in graph theory, combinatorics, combinatorial optimization, probability, computer science, discrete algorithms, complexity analysis, network design, and the information transferring models will find this book useful in their studies.

  18. Handbook of Brain Connectivity

    CERN Document Server

    Jirsa, Viktor K

    2007-01-01

    Our contemporary understanding of brain function is deeply rooted in the ideas of the nonlinear dynamics of distributed networks. Cognition and motor coordination seem to arise from the interactions of local neuronal networks, which themselves are connected in large scales across the entire brain. The spatial architectures between various scales inevitably influence the dynamics of the brain and thereby its function. But how can we integrate brain connectivity amongst these structural and functional domains? Our Handbook provides an account of the current knowledge on the measurement, analysis and theory of the anatomical and functional connectivity of the brain. All contributors are leading experts in various fields concerning structural and functional brain connectivity. In the first part of the Handbook, the chapters focus on an introduction and discussion of the principles underlying connected neural systems. The second part introduces the currently available non-invasive technologies for measuring struct...

  19. Main: Sequences [KOME

    Lifescience Database Archive (English)

    Full Text Available Sequences Amino Acid Sequence Amino Acid sequence of full length cDNA (Longest ORF) kome_ine_full_sequence..._amino_db.fasta.zip kome_ine_full_sequence_amino_db.zip kome_ine_full_sequence_amino_db ...

  20. Covariant Magnetic Connection Hypersurfaces

    CERN Document Server

    Pegoraro, F

    2016-01-01

    In the single fluid, nonrelativistic, ideal-Magnetohydrodynamic (MHD) plasma description magnetic field lines play a fundamental role by defining dynamically preserved "magnetic connections" between plasma elements. Here we show how the concept of magnetic connection needs to be generalized in the case of a relativistic MHD description where we require covariance under arbitrary Lorentz transformations. This is performed by defining 2-D {\\it magnetic connection hypersurfaces} in the 4-D Minkowski space. This generalization accounts for the loss of simultaneity between spatially separated events in different frames and is expected to provide a powerful insight into the 4-D geometry of electromagnetic fields when ${\\bf E} \\cdot {\\bf B} = 0$.

  1. Covariant magnetic connection hypersurfaces

    Science.gov (United States)

    Pegoraro, F.

    2016-04-01

    > In the single fluid, non-relativistic, ideal magnetohydrodynamic (MHD) plasma description, magnetic field lines play a fundamental role by defining dynamically preserved `magnetic connections' between plasma elements. Here we show how the concept of magnetic connection needs to be generalized in the case of a relativistic MHD description where we require covariance under arbitrary Lorentz transformations. This is performed by defining 2-D magnetic connection hypersurfaces in the 4-D Minkowski space. This generalization accounts for the loss of simultaneity between spatially separated events in different frames and is expected to provide a powerful insight into the 4-D geometry of electromagnetic fields when .

  2. Can we measure connectivity?

    Science.gov (United States)

    Brazier, Richard; Vericat, Damia; Cerda, Artemi; Brardinoni, Francesco; Batalla, Ramon; Masselink, Rens; Wittenberg, Lea; Nadal Romero, Estela; López-Tarazón, José; Estrany, Joan; Keesstra, Saskia

    2015-04-01

    Whilst the term 'connectivity' in hydrological and sediment-based research is becoming increasing well-known, it is neither used consistently in the existing literature, nor is it clear from that literature, that the connectivity of a landscape, or part of a landscape can be measured. However, it is argued that understanding how well critical source areas of water or sediment are connected to receiving surface waters, may be an essential step towards improvement of land management to mitigate flooding, soil erosion and water quality problems. The first part of this paper, therefore, explores what is currently meant by the term connectivity; addressing the differences between structural and functional, or process-based connectivity, specifically with reference to the movement of water and sediment through an ecosystem. We argue that most existing studies do not measure connectivity. Instead, they address only part of the story. Existing work may describe structural change in a landscape, which can perhaps elucidate the potential for connectivity to occur, or indeed the emergent spatial properties of an ecosystem, but it rarely quantifies the connectivity of an ecosystem in a process-based manner through time. Alternatively, a great deal of work describes fluxes of water and sediment at (sometimes multiple) points in a landscape and infers connectivity of the system via analysis of time series data; from rainfall peak to hydrograph peak or start of sediment flux until peak sediment flux within an event. Such data are doubtless useful to understand catchment function, but alone, they do not provide evidence that quantifies (for example) how well connected sediment sources are to the outlets of the catchments from which they flux. Finally, there are many examples of water and particularly sediment tracing studies, which attempt to link, either directly or indirectly water or sediment sources with their sinks (which might more usefully be termed temporary stores

  3. HIV-AIDS Connection

    Science.gov (United States)

    ... Content Marketing Share this: Main Content Area The HIV-AIDS Connection AIDS was first recognized in 1981 ... cancers. Why is there overwhelming scientific consensus that HIV causes AIDS? Before HIV infection became widespread in ...

  4. Green Connections Network

    Data.gov (United States)

    City of San Francisco — Green Connections aims to increase access to parks, open spaces, and the waterfront by envisioning a network of ���green connectors�۪ ��� city streets that will be...

  5. Connective Tissue Disorder

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    2008349 A clinical analysis of 32 patients with diffuse alveolar hemorrhage in diffuse connective tissue diseases. CHEN Guangxing(陈光星), et al. Dept Rheumatol, PUMC & CAMS Beijing 100730. Chin J Intern Med 2008;47(5):362-365.Objective To provide clues to diagnosis and treatment for diffuse alveolar hemorrhage(DAH)in patients with diffuse connective tissue diseases(CTD).Method To analyze restropectively the data of clinical features,

  6. Series connection of IGBT

    OpenAIRE

    Nguyen, The Van; Jeannin, Pierre-Olivier; Vagnon, Eric; Frey, David; Crébier, Jean-Christophe

    2010-01-01

    International audience This article analyzes the effects of parasitic capacitances in the series connection of IGBT, which exist naturally due to gate driver and power circuit geometry. Two solutions, that can be combined, are proposed to minimize these effects in order to achieve a better voltage balancing. The first one is based on gate driver self-powering technique. The second one is based on a vertical structure assembly of IGBT connected in series. The performance offered by these tw...

  7. Quick connect fastener

    Science.gov (United States)

    Weddendorf, Bruce (Inventor)

    1994-01-01

    A quick connect fastener and method of use is presented wherein the quick connect fastener is suitable for replacing available bolts and screws, the quick connect fastener being capable of installation by simply pushing a threaded portion of the connector into a member receptacle hole, the inventive apparatus being comprised of an externally threaded fastener having a threaded portion slidably mounted upon a stud or bolt shaft, wherein the externally threaded fastener portion is expandable by a preloaded spring member. The fastener, upon contact with the member receptacle hole, has the capacity of presenting cylindrical threads of a reduced diameter for insertion purposes and once inserted into the receiving threads of the receptacle member hole, are expandable for engagement of the receptacle hole threads forming a quick connect of the fastener and the member to be fastened, the quick connect fastener can be further secured by rotation after insertion, even to the point of locking engagement, the quick connect fastener being disengagable only by reverse rotation of the mated thread engagement.

  8. Strengthening connections: functional connectivity and brain plasticity

    OpenAIRE

    Kelly, Clare; Castellanos, F. Xavier

    2014-01-01

    The ascendancy of functional neuroimaging has facilitated the addition of network-based approaches to the neuropsychologist’s toolbox for evaluating the sequelae of brain insult. In particular, intrinsic functional connectivity (iFC) mapping of resting state fMRI (R-fMRI) data constitutes an ideal approach to measuring macro-scale networks in the human brain. Beyond the value of iFC mapping for charting how the functional topography of the brain is altered by insult and injury, iFC analyses c...

  9. Algebraic connectivity and graph robustness.

    Energy Technology Data Exchange (ETDEWEB)

    Feddema, John Todd; Byrne, Raymond Harry; Abdallah, Chaouki T. (University of New Mexico)

    2009-07-01

    Recent papers have used Fiedler's definition of algebraic connectivity to show that network robustness, as measured by node-connectivity and edge-connectivity, can be increased by increasing the algebraic connectivity of the network. By the definition of algebraic connectivity, the second smallest eigenvalue of the graph Laplacian is a lower bound on the node-connectivity. In this paper we show that for circular random lattice graphs and mesh graphs algebraic connectivity is a conservative lower bound, and that increases in algebraic connectivity actually correspond to a decrease in node-connectivity. This means that the networks are actually less robust with respect to node-connectivity as the algebraic connectivity increases. However, an increase in algebraic connectivity seems to correlate well with a decrease in the characteristic path length of these networks - which would result in quicker communication through the network. Applications of these results are then discussed for perimeter security.

  10. Classifying Genomic Sequences by Sequence Feature Analysis

    Institute of Scientific and Technical Information of China (English)

    Zhi-Hua Liu; Dian Jiao; Xiao Sun

    2005-01-01

    Traditional sequence analysis depends on sequence alignment. In this study, we analyzed various functional regions of the human genome based on sequence features, including word frequency, dinucleotide relative abundance, and base-base correlation. We analyzed the human chromosome 22 and classified the upstream,exon, intron, downstream, and intergenic regions by principal component analysis and discriminant analysis of these features. The results show that we could classify the functional regions of genome based on sequence feature and discriminant analysis.

  11. Multi-task Sequence to Sequence Learning

    OpenAIRE

    Luong, Minh-Thang; Le, Quoc V.; Sutskever, Ilya; Vinyals, Oriol; Kaiser, Lukasz

    2015-01-01

    Sequence to sequence learning has recently emerged as a new paradigm in supervised learning. To date, most of its applications focused on only one task and not much work explored this framework for multiple tasks. This paper examines three multi-task learning (MTL) settings for sequence to sequence models: (a) the oneto-many setting - where the encoder is shared between several tasks such as machine translation and syntactic parsing, (b) the many-to-one setting - useful when only the decoder ...

  12. Shotgun protein sequencing.

    Energy Technology Data Exchange (ETDEWEB)

    Faulon, Jean-Loup Michel; Heffelfinger, Grant S.

    2009-06-01

    A novel experimental and computational technique based on multiple enzymatic digestion of a protein or protein mixture that reconstructs protein sequences from sequences of overlapping peptides is described in this SAND report. This approach, analogous to shotgun sequencing of DNA, is to be used to sequence alternative spliced proteins, to identify post-translational modifications, and to sequence genetically engineered proteins.

  13. Connectable solar air collectors

    Energy Technology Data Exchange (ETDEWEB)

    Oestergaard Jensen, S.; Bosanac, M.

    2002-02-01

    The project has proved that it is possible to manufacture solar air collector panels, which in an easy way can be connected into large collector arrays with integrated ducting without loss of efficiency. The developed connectable solar air collectors are based on the use of matrix absorbers in the form of perforated metal sheets. Three interconnected solar air collectors of the above type - each with an transparent area of approx. 3 m{sup 2} - was tested and compared with parallel tests on two single solar air collectors also with a transparent area of approx. 3 m{sup 2} One of the single solar air collectors has an identical absorber as the connectable solar air collectors while the absorber of the other single solar air collector was a fibre cloth. The efficiency of the three solar air collectors proved to be almost identical in the investigated range of mass flow rates and temperature differences. The solar air collectors further proved to be very efficient - as efficient as the second most efficient solar air collectors tested in the IEA task 19 project Solar Air Systems. Some problems remain although to be solved: the pressure drop across especially the connectable solar air collectors is too high - mainly across the inlets of the solar air collectors. It should, however, be possible to considerably reduce the pressure losses with a more aerodynamic design of the inlet and outlet of the solar air collectors; The connectable solar air collectors are easy connectable but the air tightness of the connections in the present form is not good enough. As leakage leads to lower efficiencies focus should be put on making the connections more air tight without loosing the easiness in connecting the solar air collectors. As a spin off of the project a simple and easy way to determine the efficiency of solar, air collectors for pre-heating of fresh air has been validated. The simple method of determining the efficiency has with success been compared with an advance method

  14. VANET Connectivity Analysis

    CERN Document Server

    Kafsi, M; Dousse, O; Alpcan, T; Hubaux, J -P

    2009-01-01

    Vehicular Ad Hoc Networks (VANETs) are a peculiar subclass of mobile ad hoc networks that raise a number of technical challenges, notably from the point of view of their mobility models. In this paper, we provide a thorough analysis of the connectivity of such networks by leveraging on well-known results of percolation theory. By means of simulations, we study the influence of a number of parameters, including vehicle density, proportion of equipped vehicles, and radio communication range. We also study the influence of traffic lights and roadside units. Our results provide insights on the behavior of connectivity. We believe this paper to be a valuable framework to assess the feasibility and performance of future applications relying on vehicular connectivity in urban scenarios.

  15. Connectivity and superconductivity

    CERN Document Server

    Rubinstein, Jacob

    2000-01-01

    The motto of connectivity and superconductivity is that the solutions of the Ginzburg--Landau equations are qualitatively influenced by the topology of the boundaries, as in multiply-connected samples. Special attention is paid to the "zero set", the set of the positions (also known as "quantum vortices") where the order parameter vanishes. The effects considered here usually become important in the regime where the coherence length is of the order of the dimensions of the sample. It takes the intuition of physicists and the awareness of mathematicians to find these new effects. In connectivity and superconductivity, theoretical and experimental physicists are brought together with pure and applied mathematicians to review these surprising results. This volume is intended to serve as a reference book for graduate students and researchers in physics or mathematics interested in superconductivity, or in the Schrödinger equation as a limiting case of the Ginzburg--Landau equations.

  16. Whole Genome Sequencing

    Science.gov (United States)

    ... you want to learn. Search form Search Whole Genome Sequencing You are here Home Testing & Services Testing ... the full story, click here . What is whole genome sequencing? Whole genome sequencing is the mapping out ...

  17. Multimodal sequence learning.

    Science.gov (United States)

    Kemény, Ferenc; Meier, Beat

    2016-02-01

    While sequence learning research models complex phenomena, previous studies have mostly focused on unimodal sequences. The goal of the current experiment is to put implicit sequence learning into a multimodal context: to test whether it can operate across different modalities. We used the Task Sequence Learning paradigm to test whether sequence learning varies across modalities, and whether participants are able to learn multimodal sequences. Our results show that implicit sequence learning is very similar regardless of the source modality. However, the presence of correlated task and response sequences was required for learning to take place. The experiment provides new evidence for implicit sequence learning of abstract conceptual representations. In general, the results suggest that correlated sequences are necessary for implicit sequence learning to occur. Moreover, they show that elements from different modalities can be automatically integrated into one unitary multimodal sequence.

  18. Sequence Read Archive (SRA)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Sequence Read Archive (SRA) stores raw sequencing data from the next generation of sequencing platforms including Roche 454 GS System®, Illumina Genome...

  19. Consensus Sequence Zen

    OpenAIRE

    Schneider, Thomas D.

    2002-01-01

    Consensus sequences are widely used in molecular biology but they have many flaws. As a result, binding sites of proteins and other molecules are missed during studies of genetic sequences and important biological effects cannot be seen. Information theory provides a mathematically robust way to avoid consensus sequences. Instead of using consensus sequences, sequence conservation can be quantitatively presented in bits of information by using sequence logo graphics to repre...

  20. The Connectivity Order of Links

    CERN Document Server

    Dugowson, Stéphane

    2008-01-01

    We associate at each link a connectivity space which describes its splittability properties. Then, the notion of order for finite connectivity spaces results in the definition of a new numerical invariant for links, their connectivity order. A section of this short paper presents a theorem which asserts that every finite connectivity structure can be realized by a link : the Brunn-Debrunner-Kanenobu Theorem.

  1. On contravariant product conjugate connections

    Directory of Open Access Journals (Sweden)

    A. M. Blaga

    2012-02-01

    Full Text Available Invariance properties for the covariant and contravariant connections on a Riemannian manifold with respect to an almost product structure are stated. Restricting to a distribution of the contravariant connections is also discussed. The particular case of the conjugate connection is investigated and properties of the extended structural and virtual tensors for the contravariant connections are given.

  2. The connected brain

    NARCIS (Netherlands)

    van den Heuvel, M.P.

    2009-01-01

    The connected brain Martijn van den Heuvel, 2009 Our brain is a network. It is a network of different brain regions that are all functionally and structurally linked to each other. In the past decades, neuroimaging studies have provided a lot of information about the specific functions of each separ

  3. Connecting to Compete 2016

    OpenAIRE

    Arvis, Jean-François; Saslavsky, Daniel; Ojala, Lauri; Shepherd, Ben; Busch, Christina; Raj, Anasuya; Naula, Tapio

    2016-01-01

    The LPI has provided valuable information for policy makers, traders, and other stakeholders, including researchers and academics, on the role of logistics for growth and the policies needed to support logistics in areas such as infrastructure planning, service provision, and crossborder trade and transport facilitation. The results of Connecting to Compete 2016 point to Germany as the bes...

  4. From connection to customer

    International Nuclear Information System (INIS)

    Energy companies can no longer be certain that a customer today will remain a customer tomorrow. They have to work hard to achieve that. They are going from thinking in terms of connections to pampering their customers. Good Customer Relationship Management is a way to achieve a competitive advantage. The whole organisation has to adapt, particularly the customer orientation of employees

  5. 18.CONNECTIVE TISSUE DISORDER

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    930734 Measurement of serum soluble interleukin—2 receptor in connective tissue diseases.CAI Houronget al.Dept Intern Med,Affili Gulou Hosp,Med School,Nanjing Univ,Nanjing,210008,ShanghaiJ Immunol 1993;13(4):216—218December 1993 Vol 10 No 4

  6. High Quality Connections

    OpenAIRE

    Balslev, Lise; Molin, Jan

    2014-01-01

    Gode og stærke relationer er afgørende for en organisations livskraft. Motivation, engagement, effektivitet, kreativitet mv. er nemlig ofte direkte forbundet med organisationens evne til at skabe stærke relationer mellem ledere, medarbejdere, kunder og omverden. Jane Dutton, Professor of Business Administration and Psychology ved Michigan University, introducerer begrebet High Quality Connections (HQC) og siger.

  7. The Anansi Connection.

    Science.gov (United States)

    Carger, Chris Liska

    1998-01-01

    Describes a teacher educator's efforts to connect children's literature, sponsored by a partnership between Northern Illinois University and Chicago Public Schools. In one project, student teachers used award-winning picture books to inspire African-American eighth graders to create pastels on black paper. In another, regional folk tales inspired…

  8. Technology and Internet Connections.

    Science.gov (United States)

    Allen, Denise; Lindroth, Linda

    1996-01-01

    Suggests that teachers can use computer software and Internet connections to enhance curriculum and capitalize student's natural interest in sports and sports figures. Provides a list of activities that students can do in relation to the Olympic games and gives information on how technology can assist in such activities. Appropriate Internet…

  9. Clip, Connect, Clone

    DEFF Research Database (Denmark)

    Fujima, Jun; Lunzer, Aran; Hornbæk, Kasper Anders Søren;

    2010-01-01

    using three mechanisms: clipping of input and result elements from existing applications to form cells on a spreadsheet; connecting these cells using formulas, thus enabling result transfer between applications; and cloning cells so that multiple requests can be handled side by side. We demonstrate...

  10. Covert connection of filaments

    CERN Document Server

    Filippov, Boris

    2015-01-01

    We analyse the relationship between two near filaments, which do not show any connection in H-alpha images but reveal close magnetic connectivity during filament activations in Extreme Ultraviolet (EUV) observations. A twisted flux rope, which connects a half of one filament with another filament, becomes visible during several activations but seems to exist all the time of the filaments presence on the disc. Solar Dynamic Observatory} (SDO) and Solar Terrestrial Relations Observatory (STEREO) observed the region with the filaments from two points of view separated by the angle of about 120 deg. On 2012 July 27, SDO observed the filament activation on disc, while for the STEREO B position the filaments were visible at the limb. Nearly identical interaction episode was observed on 2012 August 04 by STEREO A on disc and by SDO at the limb. This good opportunity allows us to disentangle the 3-D shape of the connecting flux rope and in particular to determine with high reliability the helicity sign of the flux ro...

  11. An improved molecular connectivity index

    Institute of Scientific and Technical Information of China (English)

    李新华; 俞庆森; 朱龙观

    2000-01-01

    Through modification of the delta values of the molecular connectivity indexes, and connecting the quantum chemistry with topology method effectively, the molecular connectivity indexes are converted into quantum-topology indexes. The modified indexes not only keep all information obtained from the original molecular connectivity method but also have their own virtue in application, and at the same time make up some disadvantages of the quantum and molecular connectivity methods.

  12. Electronic Transport and Thermopower in Aperiodic DNA Sequences

    Science.gov (United States)

    Roche, Stephan; Maciá, Enrique

    A detailed study of charge transport properties of synthetic and genomic DNA sequences is reported. Genomic sequences of the Chromosome 22, λ-bacteriophage, and D1s80 genes of Human and Pygmy chimpanzee are considered in this work, and compared with both periodic and quasiperiodic (Fibonacci) sequences of nucleotides. Charge transfer efficiency is compared for all these different sequences, and large variations in charge transfer efficiency, stemming from sequence-dependent effects, are reported. In addition, basic characteristics of tunneling currents, including contact effects, are described. Finally, the thermoelectric power of nucleobases connected in between metallic contacts at different temperatures is presented.

  13. Strengthening connections: functional connectivity and brain plasticity.

    Science.gov (United States)

    Kelly, Clare; Castellanos, F Xavier

    2014-03-01

    The ascendancy of functional neuroimaging has facilitated the addition of network-based approaches to the neuropsychologist's toolbox for evaluating the sequelae of brain insult. In particular, intrinsic functional connectivity (iFC) mapping of resting state fMRI (R-fMRI) data constitutes an ideal approach to measuring macro-scale networks in the human brain. Beyond the value of iFC mapping for charting how the functional topography of the brain is altered by insult and injury, iFC analyses can provide insights into experience-dependent plasticity at the macro level of large-scale functional networks. Such insights are foundational to the design of training and remediation interventions that will best facilitate recovery of function. In this review, we consider what is currently known about the origin and function of iFC in the brain, and how this knowledge is informative in neuropsychological settings. We then summarize studies that have examined experience-driven plasticity of iFC in healthy control participants, and frame these findings in terms of a schema that may aid in the interpretation of results and the generation of hypotheses for rehabilitative studies. Finally, we outline some caveats to the R-fMRI approach, as well as some current developments that are likely to bolster the utility of the iFC paradigm for neuropsychology.

  14. Complex Factorizations of the Lucas Sequences via Matrix Methods

    Directory of Open Access Journals (Sweden)

    Honglin Wu

    2014-01-01

    Full Text Available Firstly, we show a connection between the first Lucas sequence and the determinants of some tridiagonal matrices. Secondly, we derive the complex factorizations of the first Lucas sequence by computing those determinants with the help of Chebyshev polynomials of the second kind. Furthermore, we also obtain the complex factorizations of the second Lucas sequence by the similar matrix method using Chebyshev polynomials of the first kind.

  15. Connectivity of neutral networks and structural conservation in protein evolution

    OpenAIRE

    Bastolla, Ugo; Porto, Markus; Roman, H. Eduardo; Vendruscolo, Michele

    2001-01-01

    Protein structures are much more conserved than sequences during evolution. Based on this observation, we investigate the consequences of structural conservation on protein evolution. We study seven of the most studied protein folds, finding out that an extended neutral network in sequence space is associated to each of them. Within our model, neutral evolution leads to a non-Poissonian substitution process, due to the broad distribution of connectivities in neutral networks. The observation ...

  16. The generalized quaternion sequence

    Science.gov (United States)

    Deveci, Ömür

    2016-04-01

    In this work, we define the recurrence sequence by using the relation matrix of the generalized quaternion group and then, we obtain miscellaneous properties of this sequence. Also, we obtain the cyclic groups and the semigroups which are produced by generating matrix of the sequence defined when read modulo m. Furthermore, we study this sequence modulo m, and then we derive the relationship among the order the cyclic groups obtained and the periods of the sequence defined.

  17. Skeletal muscle connective tissue

    DEFF Research Database (Denmark)

    Brüggemann, Dagmar Adeline

    to accumulation of intermolecular cross-links are thought to be the cause, though no cross-link could be identified, that could confirm this hypothesis. Yet, although it has never been possible to demonstrate a direct relation between the total amount of collagen and tenderness, it is still generally agreed...... composition, the organizational structure of connective tissue, the role of connective tissue in muscle contraction and the generation of force, metabolic regulation of arterial structure focusing on associated collagen changes, and a new highly-specific technique for following in three-dimensions changes...... systems of muscle have been visualized in their full complexity, including the ‘neglected' lymphatic capillaries at the level of the endomysium. These findings serve to remind us that muscle contraction is not only about force generation and transmission, but also about nutrient supply and waste removal...

  18. Network of tRNA Gene Sequences

    Institute of Scientific and Technical Information of China (English)

    WEI Fang-ping; LI Sheng; MA Hong-ru

    2008-01-01

    A network of 3719 tRNA gene sequences was constructed using simplest alignment. Its topology, degree distribution and clustering coefficient were studied. The behaviors of the network shift from fluctuated distribution to scale-free distribution when the similarity degree of the tRNA gene sequences increases. The tRNA gene sequences with the same anticodon identity are more self-organized than those with different anticodon identities and form local clusters in the network. Some vertices of the local cluster have a high connection with other local clusters, and the probable reason was given. Moreover, a network constructed by the same number of random tRNA sequences was used to make comparisons. The relationships between the properties of the tRNA similarity network and the characters of tRNA evolutionary history were discussed.

  19. Finding significantly connected voxels based on histograms of connection strengths

    DEFF Research Database (Denmark)

    Kasenburg, Niklas; Pedersen, Morten; Darkner, Sune

    2016-01-01

    We explore a new approach for structural connectivity based segmentations of subcortical brain regions. Connectivity based segmentations are usually based on fibre connections from a seed region to predefined target regions. We present a method for finding significantly connected voxels based...... on the distribution of connection strengths. Paths from seed voxels to all voxels in a target region are obtained from a shortest-path tractography. For each seed voxel we approximate the distribution with a histogram of path scores. We hypothesise that the majority of estimated connections are false......-positives and that their connection strength is distributed differently from true-positive connections. Therefore, an empirical null-distribution is defined for each target region as the average normalized histogram over all voxels in the seed region. Single histograms are then tested against the corresponding null...

  20. Empowering Human Connected Communities

    OpenAIRE

    Cerri, Stefano A.

    2012-01-01

    International audience The keynote's goal is to reflect on emergent opportunities for human Discovery (in science), Creativity (in art & industry), and Learning (in education) as processes often occurring serendipitously in individuals and in communities empowered by dynamic Web connections in the global village. These reflections seem to fit best with the mandate of the CBIE Conference: sustainable education. Having been influenced by the pioneering work of the late ecologist Francesco Di...

  1. Mobile connections : curator's statement.

    OpenAIRE

    Hemment, Drew

    2004-01-01

    The Mobile Connections exhibition at the Futuresonic 2004 festival explored how mobile and locative media reconfigure social, cultural and information space. It looked beyond computing in its current form, towards the social and cultural possibilities opened by a new generation of networked, location-aware media. It sought an art of mobile communications: asking, are there any forms of expression that are intrinsic or unique to mobile and locative media?

  2. Polynomially Bounded Sequences and Polynomial Sequences

    Directory of Open Access Journals (Sweden)

    Okazaki Hiroyuki

    2015-09-01

    Full Text Available In this article, we formalize polynomially bounded sequences that plays an important role in computational complexity theory. Class P is a fundamental computational complexity class that contains all polynomial-time decision problems [11], [12]. It takes polynomially bounded amount of computation time to solve polynomial-time decision problems by the deterministic Turing machine. Moreover we formalize polynomial sequences [5].

  3. Energy storage connection system

    Science.gov (United States)

    Benedict, Eric L.; Borland, Nicholas P.; Dale, Magdelena; Freeman, Belvin; Kite, Kim A.; Petter, Jeffrey K.; Taylor, Brendan F.

    2012-07-03

    A power system for connecting a variable voltage power source, such as a power controller, with a plurality of energy storage devices, at least two of which have a different initial voltage than the output voltage of the variable voltage power source. The power system includes a controller that increases the output voltage of the variable voltage power source. When such output voltage is substantially equal to the initial voltage of a first one of the energy storage devices, the controller sends a signal that causes a switch to connect the variable voltage power source with the first one of the energy storage devices. The controller then causes the output voltage of the variable voltage power source to continue increasing. When the output voltage is substantially equal to the initial voltage of a second one of the energy storage devices, the controller sends a signal that causes a switch to connect the variable voltage power source with the second one of the energy storage devices.

  4. Connective tissue ulcers.

    Science.gov (United States)

    Dabiri, Ganary; Falanga, Vincent

    2013-11-01

    Connective tissue disorders (CTD), which are often also termed collagen vascular diseases, include a number of related inflammatory conditions. Some of these diseases include rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis (scleroderma), localized scleroderma (morphea variants localized to the skin), Sjogren's syndrome, dermatomyositis, polymyositis, and mixed connective tissue disease. In addition to the systemic manifestations of these diseases, there are a number of cutaneous features that make these conditions recognizable on physical exam. Lower extremity ulcers and digital ulcers are an infrequent but disabling complication of long-standing connective tissue disease. The exact frequency with which these ulcers occur is not known, and the cause of the ulcerations is often multifactorial. Moreover, a challenging component of CTD ulcerations is that there are still no established guidelines for their diagnosis and treatment. The morbidity associated with these ulcerations and their underlying conditions is very substantial. Indeed, these less common but intractable ulcers represent a major medical and economic problem for patients, physicians and nurses, and even well organized multidisciplinary wound healing centers.

  5. Aromatic oligoamides with a rare ortho-connectivity

    DEFF Research Database (Denmark)

    Hjelmgaard, T.; Nielsen, John

    2013-01-01

    Even though aromatic oligoamides composed of aromatic amino acids in a "one-way sequence" attract ever increasing research interest, backbones connected through ortho-linked aromatics remain rare. Herein, we present the first synthesis and study of N-alkylated ortho-aminomethyl- benzamides termed...

  6. Genome Sequence Databases (Overview): Sequencing and Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Lapidus, Alla L.

    2009-01-01

    From the date its role in heredity was discovered, DNA has been generating interest among scientists from different fields of knowledge: physicists have studied the three dimensional structure of the DNA molecule, biologists tried to decode the secrets of life hidden within these long molecules, and technologists invent and improve methods of DNA analysis. The analysis of the nucleotide sequence of DNA occupies a special place among the methods developed. Thanks to the variety of sequencing technologies available, the process of decoding the sequence of genomic DNA (or whole genome sequencing) has become robust and inexpensive. Meanwhile the assembly of whole genome sequences remains a challenging task. In addition to the need to assemble millions of DNA fragments of different length (from 35 bp (Solexa) to 800 bp (Sanger)), great interest in analysis of microbial communities (metagenomes) of different complexities raises new problems and pushes some new requirements for sequence assembly tools to the forefront. The genome assembly process can be divided into two steps: draft assembly and assembly improvement (finishing). Despite the fact that automatically performed assembly (or draft assembly) is capable of covering up to 98% of the genome, in most cases, it still contains incorrectly assembled reads. The error rate of the consensus sequence produced at this stage is about 1/2000 bp. A finished genome represents the genome assembly of much higher accuracy (with no gaps or incorrectly assembled areas) and quality ({approx}1 error/10,000 bp), validated through a number of computer and laboratory experiments.

  7. Contamination of sequence databases with adaptor sequences

    Energy Technology Data Exchange (ETDEWEB)

    Yoshikawa, Takeo; Sanders, A.R.; Detera-Wadleigh, S.D. [National Institute of Mental Health, Bethesda, MD (United States)

    1997-02-01

    Because of the exponential increase in the amount of DNA sequences being added to the public databases on a daily basis, it has become imperative to identify sources of contamination rapidly. Previously, contaminations of sequence databases have been reported to alert the scientific community to the problem. These contaminations can be divided into two categories. The first category comprises host sequences that have been difficult for submitters to manage or control. Examples include anomalous sequences derived from Escherichia coli, which are inserted into the chromosomes (and plasmids) of the bacterial hosts. Insertion sequences are highly mobile and are capable of transposing themselves into plasmids during cloning manipulation. Another example of the first category is the infection with yeast genomic DNA or with bacterial DNA of some commercially available cDNA libraries from Clontech. The second category of database contamination is due to the inadvertent inclusion of nonhost sequences. This category includes incorporation of cloning-vector sequences and multicloning sites in the database submission. M13-derived artifacts have been common, since M13-based vectors have been widely used for subcloning DNA fragments. Recognizing this problem, the National Center for Biotechnology Information (NCBI) started to screen, in April 1994, all sequences directly submitted to GenBank, against a set of vector data retrieved from GenBank by use of key-word searches, such as {open_quotes}vector.{close_quotes} In this report, we present evidence for another sequence artifact that is widespread but that, to our knowledge, has not yet been reported. 11 refs., 1 tab.

  8. Bi-connected Gravity Fields

    CERN Document Server

    Bel, Lluís

    2016-01-01

    I describe a bi-connection formalism of General relativity based on the dual role of the Weitzenb\\"{o}ck connection defining the parallelism at a distance and the concomitant Levi-Civita connection derived from the Riemannian metric. A more explicit tensor writing of the geodesic and loxodromic equations clarifies their joint meaning.

  9. Positive fast sealing union connections

    Science.gov (United States)

    Kleber, C. M.

    1972-01-01

    Union connections are designed for connecting high pressure flexible hoses from gas storage manifolds to gas transport trailers. Connection uses O ring seals which can be quickly assembled and disassembled without use of wrenches, and which do not twist hose. Worn or damaged O rings are easily replaced.

  10. Attribute-space connected filters

    NARCIS (Netherlands)

    Wilkinson, Michael H.F.; Ronse, C; Najman, L; Decenciere, E

    2005-01-01

    In this paper connected operators from mathematical morphology are extended to a wider class of operators, which are based on connectivities in higher dimension spaces, similar to scale spaces which will be called attribute spaces. Though some properties of connected filters are lost, granulometries

  11. Connecting to Everyday Practices

    DEFF Research Database (Denmark)

    Iversen, Ole Sejer; Smith, Rachel Charlotte

    2012-01-01

    We suggest that social media can contribute to reconnecting audiences’ everyday practices to issues of cultural heritage in museum institutions. Social media can support the creation of dialogical spaces in the museum, both playful and reflective, that allow audiences to engage in the ongoing...... issues of digital heritage with audiences’ everyday practices in a museum. We point to the fact the use of social media in museums not only challenge us to rethink the design of technology for museum experiences. Social media also challenge us to rethink conceptions of museums and cultural heritage...... focusing on the connections between audiences practices and the museum exhibition....

  12. The Berry's connection

    International Nuclear Information System (INIS)

    A course on the Berry's connection is presented. The main steps leading to the Berry's discovery are reviewed and the obtained equations are examined. Some applications of Berry's formulation are presented. They include diatomic molecules, dipole-quadrupole interaction in spherical mucleus and diabolic pair transfer. The experimental results presented are the spectrum of the Na3 molecule, the propagation of photons in an helical optical fiber and the neutron spin rotation. Non-abelian problems and the Aharonow-Anandan phase are discussed

  13. Naturally Connecting the World

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ During China International Trade Fair for Home Textiles and Accessories held in Shanghai 2010(on Aug.25th the second day of the fair),Cotton Council International(CCI)hosted an exchange meeting targeted the COTTON USATM home textile licenses,taking"Naturally Connecting the World-Opportunities for Sourcing and Collaboration with Cotton-Made Home Textiles"as the theme of the meeting.CCI's representative institution in China invited the domestic famous home textile brands,enterprises and their customers to participate in the exchange which aims to introduce the current development trend of the global cotton textile industry through CCI,the powerful platform of communication.

  14. Supercomputers and biological sequence comparison algorithms.

    Science.gov (United States)

    Core, N G; Edmiston, E W; Saltz, J H; Smith, R M

    1989-12-01

    Comparison of biological (DNA or protein) sequences provides insight into molecular structure, function, and homology and is increasingly important as the available databases become larger and more numerous. One method of increasing the speed of the calculations is to perform them in parallel. We present the results of initial investigations using two dynamic programming algorithms on the Intel iPSC hypercube and the Connection Machine as well as an inexpensive, heuristically-based algorithm on the Encore Multimax.

  15. Anomaly Detection in Sequences

    Data.gov (United States)

    National Aeronautics and Space Administration — We present a set of novel algorithms which we call sequenceMiner, that detect and characterize anomalies in large sets of high-dimensional symbol sequences that...

  16. DNA sequencing conference, 2

    Energy Technology Data Exchange (ETDEWEB)

    Cook-Deegan, R.M. [Georgetown Univ., Kennedy Inst. of Ethics, Washington, DC (United States); Venter, J.C. [National Inst. of Neurological Disorders and Strokes, Bethesda, MD (United States); Gilbert, W. [Harvard Univ., Cambridge, MA (United States); Mulligan, J. [Stanford Univ., CA (United States); Mansfield, B.K. [Oak Ridge National Lab., TN (United States)

    1991-06-19

    This conference focused on DNA sequencing, genetic linkage mapping, physical mapping, informatics and bioethics. Several were used to study this sequencing and mapping. This article also discusses computer hardware and software aiding in the mapping of genes.

  17. sequenceMiner algorithm

    Data.gov (United States)

    National Aeronautics and Space Administration — Detecting and describing anomalies in large repositories of discrete symbol sequences. sequenceMiner has been open-sourced! Download the file below to try it out....

  18. Roles of repetitive sequences

    Energy Technology Data Exchange (ETDEWEB)

    Bell, G.I.

    1991-12-31

    The DNA of higher eukaryotes contains many repetitive sequences. The study of repetitive sequences is important, not only because many have important biological function, but also because they provide information on genome organization, evolution and dynamics. In this paper, I will first discuss some generic effects that repetitive sequences will have upon genome dynamics and evolution. In particular, it will be shown that repetitive sequences foster recombination among, and turnover of, the elements of a genome. I will then consider some examples of repetitive sequences, notably minisatellite sequences and telomere sequences as examples of tandem repeats, without and with respectively known function, and Alu sequences as an example of interspersed repeats. Some other examples will also be considered in less detail.

  19. Piston and connecting rod assembly

    Science.gov (United States)

    Brogdon, James William (Inventor); Gill, David Keith (Inventor); Chatten, John K. (Inventor)

    2001-01-01

    A piston and connecting rod assembly includes a piston crown, a piston skirt, a connecting rod, and a bearing insert. The piston skirt is a component separate from the piston crown and is connected to the piston crown to provide a piston body. The bearing insert is a component separate from the piston crown and the piston skirt and is fixedly disposed within the piston body. A bearing surface of a connecting rod contacts the bearing insert to thereby movably associate the connecting rod and the piston body.

  20. DNA sequences encoding erythropoietin

    Energy Technology Data Exchange (ETDEWEB)

    Lin, F.K.

    1987-10-27

    A purified and isolated DNA sequence is described consisting essentially of a DNA sequence encoding a polypeptide having an amino acid sequence sufficiently duplicative of that of erythropoietin to allow possession of the biological property of causing bone marrow cells to increase production of reticulocytes and red blood cells, and to increase hemoglobin synthesis or iron uptake.

  1. On Asymptotically Orthonormal Sequences

    OpenAIRE

    Fricain, Emmanuel; Rupam, Rishika

    2016-01-01

    An asymptotically orthonormal sequence is a sequence which is 'nearly' orthonormal in the sense that it satisfies the Parseval equality up to two constants close to one. In this paper, we explore such sequences formed by normalized reproducing kernels of model spaces and de Branges Rovnyak spaces.

  2. LHCb connects its pipes

    CERN Multimedia

    2006-01-01

    Two weeks ago the first beryllium section of the LHCb beam vacuum chamber was installed. This three-day operation, after requiring lengthy preparation work, demanded patience and precision as the first of four sections of the beampipe was connected to the vertex locator (VeLo) vacuum vessel. The AT-VAC Group with the collaboration of PH/LBD, including Gloria Corti, Tatsuya Nakada, Patrice Mermet, Delios Ramos, Frans Mul, Bruno Versollato, Bernard Corajod, and Raymond Veness. (Not pictured: Adriana Rossi and Laurent Bouvet) This first installed section is composed of a nearly two-metre long conical tube of one-millimetre thick beryllium and of a thin spherical-shaped window, 800 millimeter diameter, made of an aluminum alloy, and has the appearance of a mushroom lying on its side. The window is connected to the conical part of the beampipe through an aluminum alloy bellow, which is needed to allow for mechanical alignment once the assembly is installed. Beryllium was chosen as the material for 12 m of the 19...

  3. Whole Genome Mapping with Feature Sets from High-Throughput Sequencing Data.

    Science.gov (United States)

    Pan, Yonglong; Wang, Xiaoming; Liu, Lin; Wang, Hao; Luo, Meizhong

    2016-01-01

    A good physical map is essential to guide sequence assembly in de novo whole genome sequencing, especially when sequences are produced by high-throughput sequencing such as next-generation-sequencing (NGS) technology. We here present a novel method, Feature sets-based Genome Mapping (FGM). With FGM, physical map and draft whole genome sequences can be generated, anchored and integrated using the same data set of NGS sequences, independent of restriction digestion. Method model was created and parameters were inspected by simulations using the Arabidopsis genome sequence. In the simulations, when ~4.8X genome BAC library including 4,096 clones was used to sequence the whole genome, ~90% of clones were successfully connected to physical contigs, and 91.58% of genome sequences were mapped and connected to chromosomes. This method was experimentally verified using the existing physical map and genome sequence of rice. Of 4,064 clones covering 115 Mb sequence selected from ~3 tiles of 3 chromosomes of a rice draft physical map, 3,364 clones were reconstructed into physical contigs and 98 Mb sequences were integrated into the 3 chromosomes. The physical map-integrated draft genome sequences can provide permanent frameworks for eventually obtaining high-quality reference sequences by targeted sequencing, gap filling and combining other sequences. PMID:27611682

  4. Low autocorrelation binary sequences

    Science.gov (United States)

    Packebusch, Tom; Mertens, Stephan

    2016-04-01

    Binary sequences with minimal autocorrelations have applications in communication engineering, mathematics and computer science. In statistical physics they appear as groundstates of the Bernasconi model. Finding these sequences is a notoriously hard problem, that so far can be solved only by exhaustive search. We review recent algorithms and present a new algorithm that finds optimal sequences of length N in time O(N {1.73}N). We computed all optimal sequences for N≤slant 66 and all optimal skewsymmetric sequences for N≤slant 119.

  5. Repdigits in -Lucas Sequences

    Indian Academy of Sciences (India)

    Jhon J J Bravo; Florian Luca

    2014-05-01

    For an integer ≥ 2, let $(L_n^{(k)})_n$ be the -Lucas sequence which starts with $0,\\ldots,0,2,1$ ( terms) and each term afterwards is the sum of the preceding terms. In 2000, Luca (Port. Math. 57(2) 2000 243-254) proved that 11 is the largest number with only one distinct digit (the so-called repdigit) in the sequence $(L_n^{(2)})_n$. In this paper, we address a similar problem in the family of -Lucas sequences. We also show that the -Lucas sequences have similar properties to those of -Fibonacci sequences and occur in formulae simultaneously with the latter.

  6. Connecting the Production Multiple

    DEFF Research Database (Denmark)

    Lichen, Alex Yu; Mouritsen, Jan

    was implementing sales and operations planning (S&OP) process to foster integration on its demand chain. Although actors wanted to see what it is to produce, that is to say, the object Production, as a singular object that could be diffused across time and space, Production became more multiple because the S......&OP process itself is a fluid object, but there is still possibility to organise the messy Production. There are connections between the Production multiple and the managerial technology fluid. The fluid enacted the multiplicity of Production thus making it more difficult to be organised because there were...... always Other representations that enact new relations between presences, manifest absences and others. The multiple was organised in the sense that its mutually exclusive realities were managed by different constituents of the fluid located in these diverse realities. Accounting incompleteness...

  7. Connect the future

    Institute of Scientific and Technical Information of China (English)

    李柯翰

    2015-01-01

    <正>China has been developed so rapidly that it economic strength grows fast like a rocket.It leads China to become the World’s second-largest economy.Because the change of our life conditions,more and more people are wiling to go abroad,in order to feel the fresh air,civilized language,advanced science,and harmony atmosphere,all of these things like baptism which shocked people’s heart.The pursuit of better life quality requires more and more important elements such as beautiful landscape,clean lake,elegant buildings,rigorous law and kind people,since the beauty of landscape depends on it’s quality,the prosperity of a country rely on it’s power.I’ve been dreaming to become a messenger who can establish connect between different countries and various people.

  8. The Connectivity Analysis of Intermittent Connected Wireless Network

    Institute of Scientific and Technical Information of China (English)

    Li Yun; Zhou Yahui; Liu Qilie; Wang Xiaoying

    2009-01-01

    The connectivity is a basic and important characteristic to the network, it expresses the situation of link connectivity directly, and provides important reference for the entire network plan. Using statistics and probability Theory, this article emphasizes the probability between any two nodes in the network which nodes are equally distributed and the connectivity of whole network. At last, this article has made verification through simulation and has made out a conclusion, the simulation result agrees with theoretical analysis.

  9. Robot Sequencing and Visualization Program (RSVP)

    Science.gov (United States)

    Cooper, Brian K.; Maxwell,Scott A.; Hartman, Frank R.; Wright, John R.; Yen, Jeng; Toole, Nicholas T.; Gorjian, Zareh; Morrison, Jack C

    2013-01-01

    The Robot Sequencing and Visualization Program (RSVP) is being used in the Mars Science Laboratory (MSL) mission for downlink data visualization and command sequence generation. RSVP reads and writes downlink data products from the operations data server (ODS) and writes uplink data products to the ODS. The primary users of RSVP are members of the Rover Planner team (part of the Integrated Planning and Execution Team (IPE)), who use it to perform traversability/articulation analyses, take activity plan input from the Science and Mission Planning teams, and create a set of rover sequences to be sent to the rover every sol. The primary inputs to RSVP are downlink data products and activity plans in the ODS database. The primary outputs are command sequences to be placed in the ODS for further processing prior to uplink to each rover. RSVP is composed of two main subsystems. The first, called the Robot Sequence Editor (RoSE), understands the MSL activity and command dictionaries and takes care of converting incoming activity level inputs into command sequences. The Rover Planners use the RoSE component of RSVP to put together command sequences and to view and manage command level resources like time, power, temperature, etc. (via a transparent realtime connection to SEQGEN). The second component of RSVP is called HyperDrive, a set of high-fidelity computer graphics displays of the Martian surface in 3D and in stereo. The Rover Planners can explore the environment around the rover, create commands related to motion of all kinds, and see the simulated result of those commands via its underlying tight coupling with flight navigation, motor, and arm software. This software is the evolutionary replacement for the Rover Sequencing and Visualization software used to create command sequences (and visualize the Martian surface) for the Mars Exploration Rover mission.

  10. Constructing circuit codes by permuting initial sequences

    CERN Document Server

    Wynn, Ed

    2012-01-01

    Two new constructions are presented for coils and snakes in the hypercube. Improvements are made on the best known results for snake-in-the-box coils of dimensions 9, 10 and 11, and for some other circuit codes of dimensions between 8 and 13. In the first construction, circuit codes are generated from permuted copies of an initial transition sequence; the multiple copies constrain the search, so that long codes can be found relatively efficiently. In the second construction, two lower-dimensional paths are joined together with only one or two changes in the highest dimension; this requires a search for a permutation of the second sequence to fit around the first. It is possible to investigate sequences of vertices of the hypercube, including circuit codes, by connecting the corresponding vertices in an extended graph related to the hypercube. As an example of this, invertible circuit codes are briefly discussed.

  11. Interstate Connections - CEHC [ds619

    Data.gov (United States)

    California Department of Resources — The California Department of Transportation (Caltrans) and California Department of Fish and Game (CDFG) commissioned the California Essential Habitat Connectivity...

  12. An Optimized and Scalable Eigensolver for Sequences of Eigenvalue Problems

    CERN Document Server

    Berljafa, Mario; Di Napoli, Edoardo

    2014-01-01

    In many scientific applications the solution of non-linear differential equations are obtained through the set-up and solution of a number of successive eigenproblems. These eigenproblems can be regarded as a sequence whenever the solution of one problem fosters the initialization of the next. In addition, some eigenproblem sequences show a connection between the solutions of adjacent eigenproblems. Whenever is possible to unravel the existence of such a connection, the eigenproblem sequence is said to be a correlated. When facing with a sequence of correlated eigenproblems the current strategy amounts to solving each eigenproblem in isolation. We propose a novel approach which exploits such correlation through the use of an eigensolver based on subspace iteration and accelerated with Chebyshev polynomials (ChFSI). The resulting eigensolver, is optimized by minimizing the number of matvec multiplications and parallelized using the Elemental library framework. Numerical results shows that ChFSI achieves excell...

  13. Sequences of commutator operations

    CERN Document Server

    Aichinger, Erhard

    2012-01-01

    Given the congruence lattice L of a finite algebra A with a Mal'cev term, we look for those sequences of operations on L that are sequences of higher commutator operations of expansions of A. The properties of higher commutators proved so far delimit the number of such sequences: the number is always at most countably infinite; if it is infinite, then L is the union of two proper subintervals with nonempty intersection.

  14. Next-generation sequencing

    DEFF Research Database (Denmark)

    Rieneck, Klaus; Bak, Mads; Jønson, Lars;

    2013-01-01

    the feasibility of predicting the fetal KEL1 phenotype using next-generation sequencing (NGS) technology. STUDY DESIGN AND METHODS: The KEL1/2 single-nucleotide polymorphism was polymerase chain reaction (PCR) amplified with one adjoining base, and the PCR product was sequenced using a genome analyzer (GAIIx......, Illumina); several millions of PCR sequences were analyzed. RESULTS: The results demonstrated the feasibility of diagnosing the fetal KEL1 or KEL2 blood group from cell-free DNA purified from maternal plasma. CONCLUSION: This method requires only one primer pair, and the large amount of sequence...

  15. Ideal Systems and Connecting Orbits

    Institute of Scientific and Technical Information of China (English)

    Shu-xiang Yu; Zuo-huan Zheng; Fan-nu Hu

    2004-01-01

    In this paper,we study a class of dynamical systems in R nideal systems and give an existence criterion of quasi-connecting orbits for such systems.Also,an existence criterion of connecting orbits for general systems is given.

  16. [Muscles and connective tissue: histology].

    Science.gov (United States)

    Delage, J-P

    2012-10-01

    Here, we give some comments about the DVD movies "Muscle Attitudes" from Endovivo productions, the movies up lighting some loss in the attention given to studies on the connective tissue, and especially them into muscles. The main characteristics of the different components in the intra-muscular connective tissue (perimysium, endomysium, epimysium) are shown here with special references to their ordered architecture and special references to their spatial distributions. This connective tissue is abundant into the muscles and is in continuity with the muscles in vicinity, with their tendons and their sheath, sticking the whole on skin. This connective tissue has also very abundant connections on the muscles fibres. It is then assumed that the connective tissue sticks every organs or cells of the locomotion system. Considering the elastic properties of the collagen fibres which are the most abundant component of connective tissue, it is possible to up light a panel of connective tissue associated functions such as the transmission of muscle contractions or the regulation of protein and energetic muscles metabolism.

  17. Hitchin's connection in metaplectic quantization

    DEFF Research Database (Denmark)

    Andersen, Jørgen Ellegaard; Gammelgaard, Niels Leth; Lauridsen, Magnus Roed

    2012-01-01

    We give a differential geometric construction of a connection, which we call the Hitchin connection, in the bundle of quantum Hilbert spaces arising from metaplectically corrected geometric quantization of a prequantizable, symplectic manifold, endowed with a rigid family of Kähler structures, all...

  18. The Always-Connected Generation

    Science.gov (United States)

    Bull, Glen

    2010-01-01

    The Pew Internet and American Life project characterizes the millennials--the first generation to come of age in the new millennium--as the first "always-connected" generation. Significant aspects of culture are changing as a result. A changing world where all students are connected all the time has substantial educational implications. Despite…

  19. Algebraic Connectivity of Interdependent Networks

    NARCIS (Netherlands)

    Martin-Hernandez, J.; Wang, H.; Van Mieghem, P.; D'Agostino, G.

    2014-01-01

    The algebraic connectivity UN-1, i.e. the second smallest eigenvalue of the Laplacian matrix, plays a crucial role in dynamic phenomena such as diffusion processes, synchronization stability, and network robustness. In this work we study the algebraic connectivity in the general context of interdepe

  20. Cosmetology: Scope and Sequence.

    Science.gov (United States)

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This scope and sequence guide, developed for a cosmetology vocational education program, represents an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System. It was developed as a result of needs expressed by teachers, parents, and the…

  1. Carl Sagan's Cosmic Connection

    Science.gov (United States)

    Sagan, Carl; Agel, Jerome

    2000-08-01

    Foreword Freeman Dyson; Personal reflections Ann Druyan; Preface; Part I. Cosmic Perspective: 1. A transitional animal; 2. The Unicorn of Cetus; 3. A message from earth; 4. A message to earth; 5. Experiments in utopias; 6. Chauvinism; 7. Space exploration as a human enterprise I. The scientific interest; 8. Space exploration as a human enterprise II. The public interest; 9. Space exploration as a human enterprise III. The historical interest; Part II. The Solar System: 10. On teaching the first grade; 11. 'The ancient and legendary Gods of old'; 12. The Venus detective story; 13. Venus is hell; 14. Science and 'intelligence'; 15. The moons of Barsoom; 16. The mountains of Mars I. Observations from earth; 17. The mountains of Mars II. Observations from space; 18. The canals of Mars; 19. The lost pictures of Mars; 20. The Ice Age and the cauldron; 21. Beginnings and ends of the Earth; 22. Terraforming the plants; 23. The exploration and utlization of the solar system; Part III. Beyond the Solar System: 24. Some of my best friends are dolphins; 25. 'Hello, central casting? Send me twenty extraterrestrials'; 26. The cosmic connection; 27. Extraterrestrial life: an idea whose time has come; 28. Has the Earth been visited?; 29. A search strategy for detecting extraterrestrial intelligence; 30. If we succeed 31. Cables, drums, and seashells; 32. The night freight to the stars; 33. Astroengineering; 34. Twenty questions: a classification of cosmic civilisations; 35. Galactic cultural exchanges; 36. A passage to elsewhere; 37. Starfolk I. A Fable; 38. Starfolk II. A future; 39. Starfolk III. The cosmic Cheshire cats; Epilog David Morrison; Index.

  2. Evaluation measures of multiple sequence alignments.

    Science.gov (United States)

    Gonnet, G H; Korostensky, C; Benner, S

    2000-01-01

    Multiple sequence alignments (MSAs) are frequently used in the study of families of protein sequences or DNA/RNA sequences. They are a fundamental tool for the understanding of the structure, functionality and, ultimately, the evolution of proteins. A new algorithm, the Circular Sum (CS) method, is presented for formally evaluating the quality of an MSA. It is based on the use of a solution to the Traveling Salesman Problem, which identifies a circular tour through an evolutionary tree connecting the sequences in a protein family. With this approach, the calculation of an evolutionary tree and the errors that it would introduce can be avoided altogether. The algorithm gives an upper bound, the best score that can possibly be achieved by any MSA for a given set of protein sequences. Alternatively, if presented with a specific MSA, the algorithm provides a formal score for the MSA, which serves as an absolute measure of the quality of the MSA. The CS measure yields a direct connection between an MSA and the associated evolutionary tree. The measure can be used as a tool for evaluating different methods for producing MSAs. A brief example of the last application is provided. Because it weights all evolutionary events on a tree identically, but does not require the reconstruction of a tree, the CS algorithm has advantages over the frequently used sum-of-pairs measures for scoring MSAs, which weight some evolutionary events more strongly than others. Compared to other weighted sum-of-pairs measures, it has the advantage that no evolutionary tree must be constructed, because we can find a circular tour without knowing the tree.

  3. HIV Sequence Compendium 2015

    Energy Technology Data Exchange (ETDEWEB)

    Foley, Brian Thomas [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Leitner, Thomas Kenneth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Apetrei, Cristian [Univ. of Pittsburgh, PA (United States); Hahn, Beatrice [Univ. of Pennsylvania, Philadelphia, PA (United States); Mizrachi, Ilene [National Center for Biotechnology Information, Bethesda, MD (United States); Mullins, James [Univ. of Washington, Seattle, WA (United States); Rambaut, Andrew [Univ. of Edinburgh, Scotland (United Kingdom); Wolinsky, Steven [Northwestern Univ., Evanston, IL (United States); Korber, Bette Tina Marie [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-10-05

    This compendium is an annual printed summary of the data contained in the HIV sequence database. We try to present a judicious selection of the data in such a way that it is of maximum utility to HIV researchers. Each of the alignments attempts to display the genetic variability within the different species, groups and subtypes of the virus. This compendium contains sequences published before January 1, 2015. Hence, though it is published in 2015 and called the 2015 Compendium, its contents correspond to the 2014 curated alignments on our website. The number of sequences in the HIV database is still increasing. In total, at the end of 2014, there were 624,121 sequences in the HIV Sequence Database, an increase of 7% since the previous year. This is the first year that the number of new sequences added to the database has decreased compared to the previous year. The number of near complete genomes (>7000 nucleotides) increased to 5834 by end of 2014. However, as in previous years, the compendium alignments contain only a fraction of these. A more complete version of all alignments is available on our website, http://www.hiv.lanl.gov/ content/sequence/NEWALIGN/align.html As always, we are open to complaints and suggestions for improvement. Inquiries and comments regarding the compendium should be addressed to seq-info@lanl.gov.

  4. Mapping sequences by parts

    Directory of Open Access Journals (Sweden)

    Guziolowski Carito

    2007-09-01

    Full Text Available Abstract Background: We present the N-map method, a pairwise and asymmetrical approach which allows us to compare sequences by taking into account evolutionary events that produce shuffled, reversed or repeated elements. Basically, the optimal N-map of a sequence s over a sequence t is the best way of partitioning the first sequence into N parts and placing them, possibly complementary reversed, over the second sequence in order to maximize the sum of their gapless alignment scores. Results: We introduce an algorithm computing an optimal N-map with time complexity O (|s| × |t| × N using O (|s| × |t| × N memory space. Among all the numbers of parts taken in a reasonable range, we select the value N for which the optimal N-map has the most significant score. To evaluate this significance, we study the empirical distributions of the scores of optimal N-maps and show that they can be approximated by normal distributions with a reasonable accuracy. We test the functionality of the approach over random sequences on which we apply artificial evolutionary events. Practical Application: The method is illustrated with four case studies of pairs of sequences involving non-standard evolutionary events.

  5. Evolution of DNA Sequencing

    International Nuclear Information System (INIS)

    Sanger and coworkers introduced DNA sequencing in 1970s for the first time. It principally relied on termination of growing nucleotide chain when a dideoxythymidine triphosphate (ddTTP) was inserted in it. Detection of terminated sequences was done radiographically on Polyacrylamide Gel Electrophoresis (PAGE). Improvements that have evolved over time in original Sanger sequencing include replacement of radiography with fluorescence, use of separate fluorescent markers for each nucleotide, use of capillary electrophoresis instead of polyacrylamide gel electrophoresis and then introduction of capillary array electrophoresis. However, this technique suffered from few inherent limitations like decreased sensitivity for low level mutant alleles, complexities in analyzing highly polymorphic regions like Major Histocompatibility Complex (MHC) and high DNA concentrations required. Several Next Generation Sequencing (NGS) technologies have been introduced by Roche, Illumina and other commercial manufacturers that tend to overcome Sanger sequencing limitations and have been reviewed. Introduction of NGS in clinical research and medical diagnostics is expected to change entire diagnostic approach. These include study of cancer variants, detection of minimal residual disease, exome sequencing, detection of Single Nucleotide Polymorphisms (SNPs) and their disease association, epigenetic regulation of gene expression and sequencing of microorganisms genome. (author)

  6. Representing objects, relations, and sequences.

    Science.gov (United States)

    Gallant, Stephen I; Okaywe, T Wendy

    2013-08-01

    Vector symbolic architectures (VSAs) are high-dimensional vector representations of objects (e.g., words, image parts), relations (e.g., sentence structures), and sequences for use with machine learning algorithms. They consist of a vector addition operator for representing a collection of unordered objects, a binding operator for associating groups of objects, and a methodology for encoding complex structures. We first develop constraints that machine learning imposes on VSAs; for example, similar structures must be represented by similar vectors. The constraints suggest that current VSAs should represent phrases ("The smart Brazilian girl") by binding sums of terms, in addition to simply binding the terms directly. We show that matrix multiplication can be used as the binding operator for a VSA, and that matrix elements can be chosen at random. A consequence for living systems is that binding is mathematically possible without the need to specify, in advance, precise neuron-to-neuron connection properties for large numbers of synapses. A VSA that incorporates these ideas, Matrix Binding of Additive Terms (MBAT), is described that satisfies all constraints. With respect to machine learning, for some types of problems appropriate VSA representations permit us to prove learnability rather than relying on simulations. We also propose dividing machine (and neural) learning and representation into three stages, with differing roles for learning in each stage. For neural modeling, we give representational reasons for nervous systems to have many recurrent connections, as well as for the importance of phrases in language processing. Sizing simulations and analyses suggest that VSAs in general, and MBAT in particular, are ready for real-world applications. PMID:23607563

  7. Several graph sequences as solutions of a double recurrence

    OpenAIRE

    Brouder, Christian; Keith, William J.; Mestre, Ângela

    2013-01-01

    We describe the combinatorics that arise in summing a double recursion formula for the enumeration of connected Feynman graphs in quantum field theory. In one index the problem is more tractable and yields concise formulas which are combinatorially interesting on their own. In the other index, one of these sums is Sloane's sequence A001865.

  8. Connect the dot: Computing feed-links for network extension

    Directory of Open Access Journals (Sweden)

    Boris Aronov

    2011-12-01

    Full Text Available Road network analysis can require distance from points that are not on the network themselves. We study the algorithmic problem of connecting a point inside a face (region of the road network to its boundary while minimizing the detour factor of that point to any point on the boundary of the face. We show that the optimal single connection (feed-link can be computed in O(lambda_7(n log n time, where n is the number of vertices that bounds the face and lambda_7(n is the slightly superlinear maximum length of a Davenport-Schinzel sequence of order 7 on n symbols. We also present approximation results for placing more feed-links, deal with the case that there are obstacles in the face of the road network that contains the point to be connected, and present various related results.

  9. Framework for Connections on Facebook

    DEFF Research Database (Denmark)

    Sudzina, Frantisek

    There is a substantial amount of current information systems and marketing research focused on social networking sites, most frequently on Facebook. Often, these studies utilize available metadata on user on-line behavior, such as what links the users clicked on. In order to better understand...... behavior of Facebook users, it makes sense to investigate also whom the users connect to. It is possible to hypothesize that behavior of people, who connect only to relatives on Facebook, differs from behavior of people, who are connected only to their classmates. The paper offers a framework of Facebook...

  10. 33 CFR 156.130 - Connection.

    Science.gov (United States)

    2010-07-01

    ... operations unless it is: (1) A bolted or full threaded connection; or (2) A quick-connect coupling acceptable... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Connection. 156.130 Section 156....130 Connection. (a) Each person who makes a connection for transfer operations shall: (1) Use...

  11. Classification of base sequences

    CERN Document Server

    Djokovic, Dragomir Z

    2010-01-01

    Base sequences BS(n+1,n) are quadruples of {1,-1}-sequences (A;B;C;D), with A and B of length n+1 and C and D of length n, such that the sum of their nonperiodic autocorrelation functions is a delta-function. The base sequence conjecture, asserting that BS(n+1,n) exist for all n, is stronger than the famous Hadamard matrix conjecture. We introduce a new definition of equivalence for base sequences BS(n+1,n) and construct a canonical form. By using this canonical form, we have enumerated the equivalence classes of BS(n+1,n) for n <= 30. Due to excessive size of the equivalence classes, the tables in the paper cover only the cases n <= 12.

  12. Pierre Robin sequence

    Science.gov (United States)

    Pierre Robin syndrome; Pierre Robin complex; Pierre Robin anomaly ... The exact causes of Pierre Robin sequence are unknown. It may be part of many genetic syndromes. The lower jaw develops slowly before birth, but ...

  13. Scope and Sequence.

    Science.gov (United States)

    Callison, Daniel

    2002-01-01

    Discusses scope and sequence plans for curriculum coordination in elementary and secondary education related to school libraries. Highlights include library skills; levels of learning objectives; technology skills; media literacy skills; and information inquiry skills across disciplines by grade level. (LRW)

  14. Yeast genome sequencing:

    DEFF Research Database (Denmark)

    Piskur, Jure; Langkjær, Rikke Breinhold

    2004-01-01

    For decades, unicellular yeasts have been general models to help understand the eukaryotic cell and also our own biology. Recently, over a dozen yeast genomes have been sequenced, providing the basis to resolve several complex biological questions. Analysis of the novel sequence data has shown...... of closely related species helps in gene annotation and to answer how many genes there really are within the genomes. Analysis of non-coding regions among closely related species has provided an example of how to determine novel gene regulatory sequences, which were previously difficult to analyse because...... they are short and degenerate and occupy different positions. Comparative genomics helps to understand the origin of yeasts and points out crucial molecular events in yeast evolutionary history, such as whole-genome duplication and horizontal gene transfer(s). In addition, the accumulating sequence data provide...

  15. Biological sequence analysis

    DEFF Research Database (Denmark)

    Durbin, Richard; Eddy, Sean; Krogh, Anders Stærmose;

    This book provides an up-to-date and tutorial-level overview of sequence analysis methods, with particular emphasis on probabilistic modelling. Discussed methods include pairwise alignment, hidden Markov models, multiple alignment, profile searches, RNA secondary structure analysis, and phylogene......This book provides an up-to-date and tutorial-level overview of sequence analysis methods, with particular emphasis on probabilistic modelling. Discussed methods include pairwise alignment, hidden Markov models, multiple alignment, profile searches, RNA secondary structure analysis...

  16. HIV Sequence Compendium 2010

    Energy Technology Data Exchange (ETDEWEB)

    Kuiken, Carla [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Foley, Brian [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Leitner, Thomas [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Apetrei, Christian [Univ. of Pittsburgh, PA (United States); Hahn, Beatrice [Univ. of Alabama, Tuscaloosa, AL (United States); Mizrachi, Ilene [National Center for Biotechnology Information, Bethesda, MD (United States); Mullins, James [Univ. of Washington, Seattle, WA (United States); Rambaut, Andrew [Univ. of Edinburgh, Scotland (United Kingdom); Wolinsky, Steven [Northwestern Univ., Evanston, IL (United States); Korber, Bette [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2010-12-31

    This compendium is an annual printed summary of the data contained in the HIV sequence database. In these compendia we try to present a judicious selection of the data in such a way that it is of maximum utility to HIV researchers. Each of the alignments attempts to display the genetic variability within the different species, groups and subtypes of the virus. This compendium contains sequences published before January 1, 2010. Hence, though it is called the 2010 Compendium, its contents correspond to the 2009 curated alignments on our website. The number of sequences in the HIV database is still increasing exponentially. In total, at the time of printing, there were 339,306 sequences in the HIV Sequence Database, an increase of 45% since last year. The number of near complete genomes (>7000 nucleotides) increased to 2576 by end of 2009, reflecting a smaller increase than in previous years. However, as in previous years, the compendium alignments contain only a small fraction of these. Included in the alignments are a small number of sequences representing each of the subtypes and the more prevalent circulating recombinant forms (CRFs) such as 01 and 02, as well as a few outgroup sequences (group O and N and SIV-CPZ). Of the rarer CRFs we included one representative each. A more complete version of all alignments is available on our website, http://www.hiv.lanl.gov/content/sequence/NEWALIGN/align.html. Reprints are available from our website in the form of both HTML and PDF files. As always, we are open to complaints and suggestions for improvement. Inquiries and comments regarding the compendium should be addressed to seq-info@lanl.gov.

  17. Text Mining: (Asynchronous Sequences

    Directory of Open Access Journals (Sweden)

    Sheema Khan

    2014-12-01

    Full Text Available In this paper we tried to correlate text sequences those provides common topics for semantic clues. We propose a two step method for asynchronous text mining. Step one check for the common topics in the sequences and isolates these with their timestamps. Step two takes the topic and tries to give the timestamp of the text document. After multiple repetitions of step two, we could give optimum result.

  18. THE EXISTENCE OF CONNECTING ORBITS

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    In this paper,using the notion of an isolating block and Conley's attractor theory,an existence criterion of trajectories connecting a pair of invariant sets of ordinary differential equations is given.

  19. Cybersecurity for Connected Diabetes Devices.

    Science.gov (United States)

    Klonoff, David C

    2015-09-01

    Diabetes devices are increasingly connected wirelessly to each other and to data-displaying reader devices. Threats to the accurate flow of information and commands may compromise the function of these devices and put their users at risk of health complications. Sound cybersecurity of connected diabetes devices is necessary to maintain confidentiality, integrity, and availability of the data and commands. Diabetes devices can be hacked by unauthorized agents and also by patients themselves to extract data that are not automatically provided by product software. Unauthorized access to connected diabetes devices has been simulated and could happen in reality. A cybersecurity standard designed specifically for connected diabetes devices will improve the safety of these products and increase confidence of users that the products will be secure. PMID:25883162

  20. Nanapore Sequencing with MSPA

    Science.gov (United States)

    Gundlach, Jens H.

    2011-10-01

    Nanopore sequencing is the simplest concept of converting the sequence of a single DNA molecule directly into an electronic signal. We introduced the protein pore MspA. derived from Mycobacterium smegmatis, to nanpore sequencing [1]. MspA has a single, narrow (-1.2nm) and short (MspA is reproducible with sub-nanometer precision and is engineerable using genetic mutations. DNA moves through the pore at rates exceeding 1nt/microsec. too fast to observe the passage of each nucleotide. However, when DNA is held with double stranded DNA sections or an avidin anchor, single nucleotides resident in MspA's constriction can be identified with highly resolved current differences. We have provided proof of principle of a nanopore sequencing method [2] in which we use DNA modified by inserting double stranded DNA-sections between every nucleotide. The double stranded sections are designed to halt translocation for long enough to sequentially read the sequence of the original DNA molecule. Prospects and developments to sequence unmodified native DNA using MspA will be discussed.[4pt] [1] T.Z. Butler, et al, PNAS 105 20647 (2008)[0pt] [2] I.M. Derrington, et al, PNAS 107 16060 (2010).

  1. Cybersecurity for Connected Diabetes Devices

    OpenAIRE

    Klonoff, David C.

    2015-01-01

    Diabetes devices are increasingly connected wirelessly to each other and to data-displaying reader devices. Threats to the accurate flow of information and commands may compromise the function of these devices and put their users at risk of health complications. Sound cybersecurity of connected diabetes devices is necessary to maintain confidentiality, integrity, and availability of the data and commands. Diabetes devices can be hacked by unauthorized agents and also by patients themselves to...

  2. Connected Correlators in Quantum Gravity

    OpenAIRE

    Ambjorn, J.; Bialas, P.; Jurkiewicz, J.(Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, ul. prof. Stanislawa Lojasiewicza 11, Krakow, PL 30-348, Poland)

    1998-01-01

    We discuss the concept of connected, reparameterization invariant matter correlators in quantum gravity. We analyze the effect of discretization in two solvable cases: branched polymers and two-dimensional simplicial gravity. In both cases the naively defined connected correlators for a fixed volume display an anomalous behavior, which could be interpreted as a long-range order. We suggest that this is in fact only a highly non-trivial finite-size effect and propose an improved definition of ...

  3. Connected searching of weighted trees

    CERN Document Server

    Dereniowski, Dariusz

    2010-01-01

    In this paper we consider the problem of connected edge searching of weighted trees. It is shown that there exists a polynomial-time algorithm for finding optimal connected search strategy for bounded degree trees with arbitrary weights on the edges and vertices of the tree. The problem is NP-complete for general node-weighted trees (the weight of each edge is 1).

  4. Pleura: In connective tissue diseases

    OpenAIRE

    Kaushik Saha

    2016-01-01

    Connective tissue diseases (CTDs) (or collagen vascular diseases) represent a heterogeneous group of immunologically mediated disorders that affects many organs of the body including pleura. Frequency, presentation, and prognosis of pleural involvement depend on the underlying CTD. Connective tissue disorders may be heritable such as Marfan syndrome, Ehlers-Danlos syndrome, and osteogenesis imperfecta; and autoimmune such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), syste...

  5. Dynamical decoupling sequence construction as a filter-design problem

    CERN Document Server

    Biercuk, M J

    2010-01-01

    Over the past decade we have seen an explosion of demonstrations of quantum coherence in atomic, optical, and condensed matter systems. These developments have placed a new emphasis on the production of robust and optimal quantum control techniques in the presence of environmental noise. We discuss the use of dynamical decoupling as a form of open-loop quantum control capable of suppressing the effects of decoherence in quantum coherent systems. We introduce the concept of dynamical decoupling pulse-sequence construction as a filter-design problem, making connections with radiofrequency filter design from electrical engineering in the analysis of pulse-sequence performance. Our work takes this perspective in addressing both "standard" sequences derived from nuclear magnetic resonance and novel optimized sequences developed in the context of quantum information. We describe the physics underlying the functionality of various sequences, and compare their relative capabilities. Additionally, we review new techni...

  6. Adaptive Processing for Sequence Alignment

    KAUST Repository

    Zidan, Mohammed Affan

    2012-01-26

    Disclosed are various embodiments for adaptive processing for sequence alignment. In one embodiment, among others, a method includes obtaining a query sequence and a plurality of database sequences. A first portion of the plurality of database sequences is distributed to a central processing unit (CPU) and a second portion of the plurality of database sequences is distributed to a graphical processing unit (GPU) based upon a predetermined splitting ratio associated with the plurality of database sequences, where the database sequences of the first portion are shorter than the database sequences of the second portion. A first alignment score for the query sequence is determined with the CPU based upon the first portion of the plurality of database sequences and a second alignment score for the query sequence is determined with the GPU based upon the second portion of the plurality of database sequences.

  7. Review on Cold-Formed Steel Connections

    Directory of Open Access Journals (Sweden)

    Yeong Huei Lee

    2014-01-01

    Full Text Available The concept of cold-formed light steel framing construction has been widespread after understanding its structural characteristics with massive research works over the years. Connection serves as one of the important elements for light steel framing in order to achieve its structural stability. Compared to hot-rolled steel sections, cold-formed steel connections perform dissimilarity due to the thin-walled behaviour. This paper aims to review current researches on cold-formed steel connections, particularly for screw connections, storage rack connections, welded connections, and bolted connections. The performance of these connections in the design of cold-formed steel structures is discussed.

  8. Review on cold-formed steel connections.

    Science.gov (United States)

    Lee, Yeong Huei; Tan, Cher Siang; Mohammad, Shahrin; Tahir, Mahmood Md; Shek, Poi Ngian

    2014-01-01

    The concept of cold-formed light steel framing construction has been widespread after understanding its structural characteristics with massive research works over the years. Connection serves as one of the important elements for light steel framing in order to achieve its structural stability. Compared to hot-rolled steel sections, cold-formed steel connections perform dissimilarity due to the thin-walled behaviour. This paper aims to review current researches on cold-formed steel connections, particularly for screw connections, storage rack connections, welded connections, and bolted connections. The performance of these connections in the design of cold-formed steel structures is discussed. PMID:24688448

  9. Intermodal Passenger Connectivity Database - Raw Data

    Data.gov (United States)

    Department of Transportation — The Intermodal Passenger Connectivity Database (IPCD) is a nationwide data table of passenger transportation terminals, with data on the availability of connections...

  10. Review on Cold-Formed Steel Connections

    Science.gov (United States)

    Tan, Cher Siang; Mohammad, Shahrin; Md Tahir, Mahmood; Shek, Poi Ngian

    2014-01-01

    The concept of cold-formed light steel framing construction has been widespread after understanding its structural characteristics with massive research works over the years. Connection serves as one of the important elements for light steel framing in order to achieve its structural stability. Compared to hot-rolled steel sections, cold-formed steel connections perform dissimilarity due to the thin-walled behaviour. This paper aims to review current researches on cold-formed steel connections, particularly for screw connections, storage rack connections, welded connections, and bolted connections. The performance of these connections in the design of cold-formed steel structures is discussed. PMID:24688448

  11. Program Synthesizes UML Sequence Diagrams

    Science.gov (United States)

    Barry, Matthew R.; Osborne, Richard N.

    2006-01-01

    A computer program called "Rational Sequence" generates Universal Modeling Language (UML) sequence diagrams of a target Java program running on a Java virtual machine (JVM). Rational Sequence thereby performs a reverse engineering function that aids in the design documentation of the target Java program. Whereas previously, the construction of sequence diagrams was a tedious manual process, Rational Sequence generates UML sequence diagrams automatically from the running Java code.

  12. What is next generation sequencing?

    OpenAIRE

    Behjati, Sam; Tarpey, Patrick S.

    2013-01-01

    Next generation sequencing (NGS), massively parallel or deep sequencing are related terms that describe a DNA sequencing technology which has revolutionised genomic research. Using NGS an entire human genome can be sequenced within a single day. In contrast, the previous Sanger sequencing technology, used to decipher the human genome, required over a decade to deliver the final draft. Although in genome research NGS has mostly superseded conventional Sanger sequencing, it has not yet translat...

  13. Visualizing neuronal network connectivity with connectivity pattern tables

    Directory of Open Access Journals (Sweden)

    Eilen Nordlie

    2010-01-01

    Full Text Available Complex ideas are best conveyed through well-designed illustrations. Up to now, computational neuroscientists have mostly relied on box-and-arrow diagrams of even complex neuronal networks, often using ad hoc notations with conflicting use of symbols from paper to paper. This significantly impedes the communication of ideas in neuronal network modeling. We present here Connectivity Pattern Tables (CPTs as a clutter-free visualization of connectivity in large neuronal networks containing two-dimensional populations of neurons. CPTs can be generated automatically from the same script code used to create the actual network in the NEST simulator. Through aggregation, CPTs can be viewed at different levels, providing either full detail or summary information. We also provide the open source ConnPlotter tool as a means to create connectivity pattern tables.

  14. Ternary Chaotic Pulse Compression Sequences

    Directory of Open Access Journals (Sweden)

    J. B. Seventline

    2010-09-01

    Full Text Available In this paper method available for generating ternary sequences is discussed. These sequences are useful in many applications but specifically in synchronization of block codes and pulse compression in radar. The ternary sequences are derived from chaotic maps. It is feasible to achieve simultaneously superior performances in detection range and range resolution using the proposed ternary sequences. The properties of these sequences like autocorrelation function, Peak Side Lobe Ratio (PSLR, ambiguity diagram and performance under AWGN noise background has been studied. The generation of these sequences is much simpler, and the available number of sequences is virtually infinite and not limited by the length of the sequence.

  15. A^I-statistical convergence with respect to a sequence of modulus functions

    OpenAIRE

    Yamancı, Ulaş; GÜRDAL, MEHMET; Saltan, Suna

    2012-01-01

    In this paper, we introduce the notion of A^{I}-[V,λ]-summability and A^{I}-λ-statistical convergence with respect to a sequence of modulus functions. We basically study some connections between A^{I}-λ-statistical convergence and A^{I}-statistical convergence with respect to a sequence of modulus functions.

  16. Extremal properties of (epi)Sturmian sequences and distribution modulo 1

    OpenAIRE

    Allouche, Jean-Paul; Glen, Amy

    2009-01-01

    Starting from a study of Y. Bugeaud and A. Dubickas (2005) on a question in distribution of real numbers modulo 1 via combinatorics on words, we survey some combinatorial properties of (epi)Sturmian sequences and distribution modulo 1 in connection to their work. In particular we focus on extremal properties of (epi)Sturmian sequences, some of which have been rediscovered several times.

  17. Sequencing BPS Spectra

    CERN Document Server

    Gukov, Sergei; Saberi, Ingmar; Stosic, Marko; Sulkowski, Piotr

    2015-01-01

    This paper provides both a detailed study of color-dependence of link homologies, as realized in physics as certain spaces of BPS states, and a broad study of the behavior of BPS states in general. We consider how the spectrum of BPS states varies as continuous parameters of a theory are perturbed. This question can be posed in a wide variety of physical contexts, and we answer it by proposing that the relationship between unperturbed and perturbed BPS spectra is described by a spectral sequence. These general considerations unify previous applications of spectral sequence techniques to physics, and explain from a physical standpoint the appearance of many spectral sequences relating various link homology theories to one another. We also study structural properties of colored HOMFLY homology for links and evaluate Poincar\\'e polynomials in numerous examples. Among these structural properties is a novel "sliding" property, which can be explained by using (refined) modular $S$-matrix. This leads to the identifi...

  18. Continuously Connected With Mobile IP

    Science.gov (United States)

    2002-01-01

    Cisco Systems developed Cisco Mobile Networks, making IP devices mobile. With this innovation, a Cisco router and its connected IP devices can roam across network boundaries and connection types. Because a mobile user is able to keep the same IP address while roaming, a live IP connection can be maintained without interruption. Glenn Research Center jointly tested the technology with Cisco, and is working to use it on low-earth-orbiting research craft. With Cisco's Mobile Networks functionality now available in Cisco IOS Software release 12.2(4)T, the commercial advantages and benefits are numerous. The technology can be applied to public safety, military/homeland security, emergency management services, railroad and shipping systems, and the automotive industry. It will allow ambulances, police, firemen, and the U.S. Coast Guard to stay connected to their networks while on the move. In the wireless battlefield, the technology will provide rapid infrastructure deployment for U.S. national defense. Airline, train, and cruise passengers utilizing Cisco Mobile Networks can fly all around the world with a continuous Internet connection. Cisco IOS(R) Software is a registered trademark of Cisco Systems.

  19. Neutral Networks of Sequence to Shape Maps

    CERN Document Server

    Jin, Emma Y; Reidys, Christian M

    2007-01-01

    In this paper we present a novel framework for sequence to shape maps. These combinatorial maps realize exponentially many shapes, and have preimages which contain extended connected subgraphs of diameter $n$ (neutral networks). We prove that all basic properties of RNA folding maps also hold for combinatorial maps. Our construction is as follows: suppose we are given a graph $H$ over the $\\{1 ...,n\\}$ and an alphabet of nucleotides together with a symmetric relation $\\mathcal{R}$, implied by base pairing rules. Then the shape of a sequence of length $n$ is the maximal $H$ subgraph in which all pairs of nucleotides incident to $H$-edges satisfy $\\mathcal{R}$. Our main result is to prove the existence of at least $\\sqrt{2}^{n-1}$ shapes with extended neutral networks, i.e. shapes that have a preimage with diameter $n$ and a connected component of size at least $(\\frac{1+\\sqrt{5}}{2})^n+(\\frac{1-\\sqrt{5}}{2})^n$. Furthermore, we show that there exists a certain subset of shapes which carries a natural graph str...

  20. Connected correlators in quantum gravity

    International Nuclear Information System (INIS)

    We discuss the concept of connected, reparameterization invariant matter correlators in quantum gravity. We analyze the effect of discretization in two solvable cases: branched polymers and two-dimensional simplicial gravity. In both cases the naively defined connected correlators for a fixed volume display an anomalous behavior, which could be interpreted as a long-range order. We suggest that this is in fact only a highly non-trivial finite-size effect and propose an improved definition of the connected correlator, which reduces the effect. Using this definition we illustrate the appearance of a long-range spin order in the Ising model on a two-dimensional random lattice in an external magnetic field H, when H to 0 and β=βC. (author)

  1. MANAGERS CONNECTED THROUGH INFORMATION TECHNOLOGY

    Directory of Open Access Journals (Sweden)

    Osmarina Pedro Garcia Garcia

    2015-06-01

    Full Text Available This study had as its central objective to ascertain how managers connect with information technology. The methodology applied was an exploratory research, through a structured questionnaire survey based on qualitative and quantitative approach. The study interviewed eighteen managers in a city in Brazil (Cascavel – Paraná, from the industrial segment distributed in several areas, selected by the non-probabilistic method, considering the samples by convenience. The research results showed that the respondents connect with information technology through social networks, applications and technological devices in a normal deliberated way. Literature has showed that Brazil is the second most connected country in social networks, which shows that managers tend to increase the use of information technology over time. We concluded that when managers use those technological tools, are online frequently, to fulfill their entrepreneurial functions, they remain attentive to everything that is happening around them and globally.

  2. Pleura: In connective tissue diseases

    Directory of Open Access Journals (Sweden)

    Kaushik Saha

    2016-01-01

    Full Text Available Connective tissue diseases (CTDs (or collagen vascular diseases represent a heterogeneous group of immunologically mediated disorders that affects many organs of the body including pleura. Frequency, presentation, and prognosis of pleural involvement depend on the underlying CTD. Connective tissue disorders may be heritable such as Marfan syndrome, Ehlers-Danlos syndrome, and osteogenesis imperfecta; and autoimmune such as systemic lupus erythematosus (SLE, rheumatoid arthritis (RA, systemic sclerosis, mixed connective tissue disease (MCTD, Sjögren's syndrome (SS, dermatomyositis (DM, and polymyositis (PM. The subject of this review is to describe the variety of pleural disorders observed in the most frequent types of CTD: SLE, RA, scleroderma, SS, DM, PM, and MCTD.

  3. The solar-stellar connection

    Science.gov (United States)

    Giampapa, Mark S.

    2016-07-01

    A review of some principal results achieved in the area of stellar astrophysics with its origins in solar physics - the Solar-Stellar Connection - is presented from the perspective of an observational astronomer. The historical origins of the Solar-Stellar Connection are discussed followed by a review of key results from observations of stellar cycles analogous to the solar cycle in terms of parameters relevant to dynamo theory. A review of facets of angular momentum evolution and irradiance variations, each of which is determined by emergent, dynamo-generated magnetic fields, is given. Recent considerations of the impacts of stellar magnetic activity on the ambient radiative and energetic particle environment of the habitable zone of exoplanet systems are summarized. Some anticipated directions of the Solar-Stellar Connection in the new era of astronomy as defined by the advent of transformative facilities are presented.

  4. Grouted Connections with Shear Keys

    DEFF Research Database (Denmark)

    Pedersen, Ronnie; Jørgensen, M. B.; Damkilde, Lars;

    2012-01-01

    This paper presents a finite element model in the software package ABAQUS in which a reliable analysis of grouted pile-to-sleeve connections with shear keys is the particular purpose. The model is calibrated to experimental results and a consistent set of input parameters is estimated so that dif......This paper presents a finite element model in the software package ABAQUS in which a reliable analysis of grouted pile-to-sleeve connections with shear keys is the particular purpose. The model is calibrated to experimental results and a consistent set of input parameters is estimated so...

  5. An efficient algorithm for identifying matches with errors in multiple long molecular sequences.

    Science.gov (United States)

    Leung, M Y; Blaisdell, B E; Burge, C; Karlin, S

    1991-10-20

    An efficient algorithm is described for finding matches, repeats and other word relations, allowing for errors, in large data sets of long molecular sequences. The algorithm entails hashing on fixed-size words in conjunction with the use of a linked list connecting all occurrences of the same word. The average memory and run time requirement both increase almost linearly with the total sequence length. Some results of the program's performance on a database of Escherichia coli DNA sequences are presented.

  6. Instruction sequence processing operators

    NARCIS (Netherlands)

    J.A. Bergstra; C.A. Middelburg

    2009-01-01

    This paper concerns instruction sequences whose execution involves the processing of instructions by an execution environment that offers a family of services and may yield a Boolean value at termination. We introduce a composition operator for families of services and three operators that have a di

  7. THE RHIC SEQUENCER.

    Energy Technology Data Exchange (ETDEWEB)

    VAN ZEIJTS,J.; DOTTAVIO,T.; FRAK,B.; MICHNOFF,R.

    2001-06-18

    The Relativistic Heavy Ion Collider (RHIC) has a high level asynchronous time-line driven by a controlling program called the ''Sequencer''. Most high-level magnet and beam related issues are orchestrated by this system. The system also plays an important task in coordinated data acquisition and saving. We present the program, operator interface, operational impact and experience.

  8. Twin anemia polycythemia sequence

    NARCIS (Netherlands)

    Slaghekke, Femke

    2014-01-01

    In this thesis we describe that Twin Anemia Polycythemia Sequence (TAPS) is a form of chronic feto-fetal transfusion in monochorionic (identical) twins based on a small amount of blood transfusion through very small anastomoses. For the antenatal diagnosis of TAPS, Middle Cerebral Artery – Peak Syst

  9. 46 CFR 98.30-27 - Connections.

    Science.gov (United States)

    2010-10-01

    ... operations unless it is— (1) A bolted or full threaded connection; or (2) A quick-connect coupling accepted.... (a) Each person who makes a connection for a transfer operation shall— (1) Use suitable material in... less than four bolts in each temporary connection utilizing an American National Standards...

  10. A test of the multiple connections model of reading acquisition.

    Science.gov (United States)

    Berninger, V W; Chen, A C; Abbott, R D

    1988-10-01

    Within the framework of Society of Mind Theory (Minsky, 1986), learning to read is conceptualized as a process of creating new communication links or neural connections between an existing visual society and an existing linguistic society. Four visual-linguistic connections may become functional: letter-phonemic code, whole word-semantic code, whole word-name code, letter sequence-aural syllabic code. The hypothesis was tested that more than one of these visual-linguistic connections must be taken into account in predicting reading achievement. Results showed that the combination of the composite letter-phoneme variable and the composite whole word-semantic code variable accounted for significantly more variance in oral reading than did either single variable at the end of the first grade. Groups with large absolute discrepancy (1 or more standard scores) or small absolute discrepancy (1/3 standard score or less) on corresponding visual and linguistic skills differed significantly in both oral (whole word-semantic code composite) and silent reading (whole word-semantic code and letter sequence-aural syllabic code composites). There was a relationship between the number of large discrepancies and reading achievement. Results are discussed in reference to neuropsychological models of connectionism (Rumelhart & McClelland, 1986) and working brain systems (Luria, 1973).

  11. The Reading/Writing Connection.

    Science.gov (United States)

    Anderson, Nancy Comfort

    1998-01-01

    Discusses ways to motivate children to become readers and writers, characteristics of good children's literature, using patterned books as models, and prewriting activities; provides an annotated bibliography of 26 patterned books to encourage the reading/writing connection. A subset of updated folk and fairy tales is included. (LRW)

  12. Connecting musicological tools with Europeana

    NARCIS (Netherlands)

    van Berchum, M.

    2015-01-01

    Within the Europeana Cloud project (see http://pro.europeana.eu/web/europeana- cloud) small research groups are engaged in the development of new research tools, connected to the content present in Europeana. In 2014 a group of musicologists working on early music subjects was invited to participate

  13. Gigabit Wireless for Network Connectivity

    Science.gov (United States)

    Schoedel, Eric

    2009-01-01

    Uninterrupted, high-bandwidth network connectivity is crucial for higher education. Colleges and universities increasingly adopt gigabit wireless solutions because of their fiber-equivalent performance, quick implementation, and significant return on investment. For just those reasons, Rush University Medical Center switched from free space optics…

  14. Connecting the Dots: Rediscovering Continuity

    Science.gov (United States)

    Camenga, Kristin A.; Yates, Rebekah B. Johnson

    2014-01-01

    The topic of continuity is typically not introduced until calculus and then reexamined in real analysis. Recognizing the connections between secondary school mathematics and the advanced mathematics studied at the college level allows teachers to better identify mathematical concepts in student ideas, motivate students by piquing their curiosity,…

  15. Mundtlig eksamen via Adobe Connect

    DEFF Research Database (Denmark)

    Kjær, Christopher

    2011-01-01

    I løbet af de sidste tre år har der på Syddansk Universitet (SDU) været afholdt mere end 20 mundtlige kandidatforsvar samt andre mundtlige eksaminationer via webkonferencesystemet Adobe Connect. Formålet med denne artikel er at videregive de praktiske erfaringer fra gennemførelsen af disse...... eksaminationer samt at opstille nogle hensigtsmæssige retningslinjer for dem, der ønsker at give sig i kast med mundtlig eksamination via Adobe Connect. Der indledes derfor med en generel præsentation af Adobe Connect samt de elementer ved systemet, som oftest anvendes i forbindelse med mundtlig eksamination....... Heref ter præsenteres de typiske årsager til, at Adobe Connect anvendes til eksamination. I forlængelse heraf gennemgås nogle scenarier for afholdelse af mundtlig eksamination i systemet. Nogle af disse scenarier suppleres med beskrivelser af deltagernes oplevelser og erfaringer med gennemførelsen af...

  16. Liaison concatenation – A method to obtain feasible assembly sequences from 3D-CAD product

    Indian Academy of Sciences (India)

    M V A Raju Bahubalendruni; Bibhuti Bhusan Biswal

    2016-01-01

    Selection of optimized assembly sequence from the available feasible assembly sequences is significantly essential to achieve cost-effective manufacturing process. To achieve this, at the outset, generation of feasible assembly sequences with topological, geometrical, precedence and stability conditions should be generated. The increase of part count in a product results huge number of assembly sequences, the Liaison matrix/Liaison graph generated based on the connections between the assembly components eliminates nonpossible assembly sequences at the initial phase. There exist methods namely cut-set method to eliminate the non-possible assembly sequences using liaison graph. In this paper a new approach to eliminate the non-possible assembly sequences based on liaisons is described and the correctness of the methodology is illustrated with an example. The methodology to obtain the feasible assembly sequences is also briefly described and presented. An algorithm to interface with the CAD environment is described briefly.

  17. Properties of Semijoin Sequences

    Institute of Scientific and Technical Information of China (English)

    BengC.Ooi; B.Srinivasan

    1989-01-01

    The problem of finding optimum semijoin sequ4ence of an arbitrary query under linear cost function for the transmission cost is NP.hard.Hence heuristic algorithms with desirable properties are explored.In this paper four properties of semijoin programs for distributed query processing are identified,The use of these properties in constructing semijoin sequence is justified.An existing algorithm is modified incorporating these properties.Empirical comparison with existing algorithms shows the superiority of the proposed algorithm.

  18. Learning Sequence Neighbourhood Metrics

    CERN Document Server

    Bayer, Justin; van der Smagt, Patrick

    2011-01-01

    Recurrent neural networks (RNNs) in combination with a pooling operator and the neighbourhood components analysis (NCA) objective function are able to detect the characterizing dynamics of sequences and embed them into a fixed-length vector space of arbitrary dimensionality. Subsequently, the resulting features are meaningful and can be used for visualization or nearest neighbour classification in linear time. This kind of metric learning for sequential data enables the use of algorithms tailored towards fixed length vector spaces such as R^n.

  19. Sequence Classification: 885394 [

    Lifescience Database Archive (English)

    Full Text Available 703); The expression pattern of this gene is described in PMID:12000842; possible frameshift detected when compared...Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|23619146|ref|NP_705108.1| Slight difference exist when compa...red to the published sequence of EBL-1 from Dd2 strain of P. falciparum (PMID:10613

  20. Connecting leadership and learning: Do versatile learners make connective leaders?

    OpenAIRE

    Robinson, Jill L.

    2016-01-01

    Recent failures in leadership, suggest that creating better-quality leadership development programs is critical. In moving from theory to practice, this paper examined the relationship between learning style and leadership style which may enable us to move away from one-size-fits-all leadership development programs. Utilizing Kolb’s Experiential Learning Model and Connective Leadership theory, approximately 3600 college students were analyzed to discover whether versatility in learning styles...

  1. Image sequence analysis

    CERN Document Server

    1981-01-01

    The processing of image sequences has a broad spectrum of important applica­ tions including target tracking, robot navigation, bandwidth compression of TV conferencing video signals, studying the motion of biological cells using microcinematography, cloud tracking, and highway traffic monitoring. Image sequence processing involves a large amount of data. However, because of the progress in computer, LSI, and VLSI technologies, we have now reached a stage when many useful processing tasks can be done in a reasonable amount of time. As a result, research and development activities in image sequence analysis have recently been growing at a rapid pace. An IEEE Computer Society Workshop on Computer Analysis of Time-Varying Imagery was held in Philadelphia, April 5-6, 1979. A related special issue of the IEEE Transactions on Pattern Anal­ ysis and Machine Intelligence was published in November 1980. The IEEE Com­ puter magazine has also published a special issue on the subject in 1981. The purpose of this book ...

  2. Implicit sequence learning in people with Parkinson’s disease

    Directory of Open Access Journals (Sweden)

    Katherine R Gamble

    2014-08-01

    Full Text Available Implicit sequence learning involves learning about dependencies in sequences of events without intent to learn or awareness of what has been learned. Sequence learning is related to striatal dopamine levels, striatal activation, and integrity of white matter connections. People with Parkinson’s disease (PD have degeneration of dopamine-producing neurons, leading to dopamine deficiency and therefore striatal deficits, and they have difficulties with sequencing, including complex language comprehension and postural stability. Most research on implicit sequence learning in PD has used motor-based tasks. However, because PD presents with motor deficits, it is difficult to assess whether learning itself is impaired in these tasks. The present study used an implicit sequence learning task with a reduced motor component, the Triplets Learning Task (TLT. People with PD and age- and education-matched healthy older adults completed three sessions (each consisting of 10 blocks of 50 trials of the TLT. Results revealed that the PD group was able to learn the sequence, however, when learning was examined using a Half Blocks analysis (Nemeth et al., 2013, which compared learning in the 1st 25/50 trials of all blocks to that in the 2nd 25/50 trials, the PD group showed significantly less learning than Controls in the 2nd Half Blocks, but not in the 1st. Nemeth et al. hypothesized that the 1st Half Blocks involve recall and reactivation of the sequence learned, thus reflecting hippocampal-dependent learning, while the 2nd Half Blocks involve proceduralized behavior of learned sequences, reflecting striatal-based learning. The present results suggest that the PD group had intact hippocampal-dependent implicit sequence learning, but impaired striatal-dependent learning. Thus, sequencing deficits in PD are likely due to striatal impairments, but other brain systems, such as the hippocampus, may be able to partially compensate for striatal decline to improve

  3. Pengurangan Arus Harmonisa Urutan Nol Dengan Zero Sequence Blocking Transformer Dan Transformator Zig-Zag Yang Menggunakan Tiga Buah Transformator Satu Fasa

    OpenAIRE

    Pane, Zulkarnaen

    2014-01-01

    The zero-sequence harmonics current or the third sequence of harmonic current generated by non-linear loads potentially cause power quality problems on 4-wires 3-phase distributed systems. This research exposes an harmonic current suppression method by utilizing a zero sequence blocking transformer and a zig-zag transformer which employ three single-phase transformers. The zero sequence blocking transformer is connected serially to the power source to generate a high zero sequence impedance, ...

  4. ConnectED: President Obama's Plan for Connecting All Schools to the Digital Age

    Science.gov (United States)

    The White House, 2013

    2013-01-01

    Driven by new digital technologies, the future of learning is increasingly interactive, individualized, and full of real-world experiences and information. Unfortunately, the average school has about the same connectivity as the average American home, but serves 200 times as many users, and fewer than 20 percent of educators say their school's…

  5. Information Theory of DNA Sequencing

    CERN Document Server

    Motahari, Abolfazl; Tse, David

    2012-01-01

    DNA sequencing is the basic workhorse of modern day biology and medicine. Shotgun sequencing is the dominant technique used: many randomly located short fragments called reads are extracted from the DNA sequence, and these reads are assembled to reconstruct the original sequence. By drawing an analogy between the DNA sequencing problem and the classic communication problem, we define an information theoretic notion of sequencing capacity. This is the maximum number of DNA base pairs that can be resolved reliably per read, and provides a fundamental limit to the performance that can be achieved by any assembly algorithm. We compute the sequencing capacity explicitly for a simple statistical model of the DNA sequence and the read process. Using this framework, we also study the impact of noise in the read process on the sequencing capacity.

  6. Next-generation sequencing approaches in genetic rodent model systems to study functional effects of human genetic variation

    NARCIS (Netherlands)

    Guryev, Victor; Cuppen, Edwin

    2009-01-01

    Rapid advances in DNA sequencing improve existing techniques and enable new approaches in genetics and functional genomics, bringing about unprecedented coverage, resolution and sensitivity. Enhanced toolsets can facilitate the untangling of connections between genomic variation, environmental facto

  7. Next-generation sequencing approaches in genetic rodent model systems to study functional effects of human genetic variation.

    NARCIS (Netherlands)

    Guryev, V.; Cuppen, E.

    2009-01-01

    Rapid advances in DNA sequencing improve existing techniques and enable new approaches in genetics and functional genomics, bringing about unprecedented coverage, resolution and sensitivity. Enhanced toolsets can facilitate the untangling of connections between genomic variation, environmental facto

  8. Psychoacoustic Properties of Fibonacci Sequences

    Directory of Open Access Journals (Sweden)

    J. Sokoll

    2008-01-01

    Full Text Available 1202, Fibonacci set up one of the most interesting sequences in number theory. This sequence can be represented by so-called Fibonacci Numbers, and by a binary sequence of zeros and ones. If such a binary Fibonacci Sequence is played back as an audio file, a very dissonant sound results. This is caused by the “almost-periodic”, “self-similar” property of the binary sequence. The ratio of zeros and ones converges to the golden ratio, as do the primary and secondary spectral components intheir frequencies and amplitudes. These Fibonacci Sequences will be characterized using listening tests and psychoacoustic analyses. 

  9. Formal connections in deformation quantization

    DEFF Research Database (Denmark)

    Masulli, Paolo

    The field of this thesis is deformation quantization, and we consider mainly symplectic manifolds equipped with a star product. After reviewing basics in complex geometry, we introduce quantization, focusing on geometric quantization and deformation quantization. The latter is defined as a star...... manifold. Gammelgaard gave an explicit formula for a class of star products in this setting. We review his construction, which is combinatorial and based on a certain family of graphs and extend it, to provide the graph formalism with the notions of composition and differentiation. We shall focus our...... products. Afterwards we study the problem of trivializing a formal connection, that is to define a differential operator on the manifold which makes any section of the bundle parallel with respect to the connection. To approach the problem we use the graph formalism described above to encode it in graph...

  10. Correlating thalamocortical connectivity and activity

    Science.gov (United States)

    da Fontoura Costa, Luciano; Sporns, Olaf

    2006-07-01

    The segregated regions of the mammalian cerebral cortex and thalamus form an extensive and complex network, whose structure and function are still only incompletely understood. The present letter describes an application of the concepts of complex networks and random walks that allows the identification of nonrandom, highly structured features of thalamocortical connections and their potential effects on dynamic interactions between cortical areas in the cat brain. Utilizing large-scale anatomical data sets of this thalamocortical system, we investigate uniform random walks in such a network by considering the steady state eigenvector of the respective stochastic matrix. It is shown that thalamocortical connections are organized in such a way as to guarantee strong correlation between the outdegree and occupancy rate (a stochastic measure potentially related to activation) of each cortical area. Possible organizational principles underlying this effect are identified and discussed.

  11. 78 FR 28626 - Te Connectivity, Industrial Division, Middletown, Pennsylvania; Te Connectivity, Corporate Shared...

    Science.gov (United States)

    2013-05-15

    ..., Corporate Shared Services Group 100 & 200 Amp Drive, Harrisburg, Pennsylvania; Te Connectivity Corporate Shared Services Group, 3700 Reidsville Road, Winston-Salem, North Carolina; Te Connectivity, Corporate Shared Services Group, 1187 Park Place, Shakopee, Minnesota; Te Connectivity, Corporate Shared...

  12. Connection between Transmission Quality Parametrs

    Directory of Open Access Journals (Sweden)

    Andrej Sulovec

    2003-01-01

    Full Text Available Errors occuring in digital transmission are the major source of degradation in that they affect voice services in terms of distortion of voice, and data type services in terms of lost or inaccurate information or reduces throughput. Therefore International Telecommunication Union ITU-T defined some objectives that enable to express the measure of digital transmission quality. It is often necessary to know the connection between these parameters.

  13. Connection between Transmission Quality Parametrs

    OpenAIRE

    Andrej Sulovec

    2003-01-01

    Errors occuring in digital transmission are the major source of degradation in that they affect voice services in terms of distortion of voice, and data type services in terms of lost or inaccurate information or reduces throughput. Therefore International Telecommunication Union ITU-T defined some objectives that enable to express the measure of digital transmission quality. It is often necessary to know the connection between these parameters.

  14. Connecting Remote Clusters with ATM

    Energy Technology Data Exchange (ETDEWEB)

    Hu, T.C.; Wyckoff, P.S.

    1998-10-01

    Sandia's entry into utilizing clusters of networked workstations is called Computational Plant or CPlant for short. The design of CPlant uses Ethernet to boot the individual nodes, Myrinet to communicate within a node cluster, and ATM to connect between remote clusters. This SAND document covers the work done to enable the use of ATM on the CPlant nodes in the Fall of 1997.

  15. The Galaxy Dark Matter Connection

    OpenAIRE

    Bosch, Frank C. van den; Yang, Xiaohu; Mo, H. J.

    2004-01-01

    What galaxy lives in what halo? The answer to this simple question holds important information regarding galaxy formation and evolution. We describe a new statistical technique to link galaxies to their dark matter haloes, or light to mass, using the clustering properties of galaxies as function of their luminosity. The galaxy-dark matter connection thus established, and parameterized through the conditional luminosity function, indicates the presence of two characteristic scales in galaxy fo...

  16. Autoimmune Hepatitis and PSC Connection.

    Science.gov (United States)

    Vergani, Diego; Mieli-Vergani, Giorgina

    2008-02-01

    This article describes the connection between autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC). The two conditions have chronicity, liver inflammation, and a positive autoimmune serology in common; they differ in terms of gender distribution and bile duct damage. There is evidence suggesting that AIH and PSC are immune-mediated diseases. PSC and AIH could lie within the spectrum of the same disease process. Future studies should determine how frequently AIH evolves to PSC.

  17. Critical Connections: Health and Academics

    OpenAIRE

    Michael, Shannon L; Merlo, Caitlin L.; Basch, Charles E.; Wentzel, Kathryn R; Wechsler, Howell

    2015-01-01

    BACKGROUND While it is a national priority to support the health and education of students, these sectors must better align, integrate, and collaborate to achieve this priority. This article summarizes the literature on the connection between health and academic achievement using the Whole School, Whole Community, and Whole Child (WSCC) framework as a way to address health-related barriers to learning. METHODS A literature review was conducted on the association between student health and aca...

  18. MANAGERS CONNECTED THROUGH INFORMATION TECHNOLOGY

    OpenAIRE

    Osmarina Pedro Garcia Garcia; Claudio Mioranza; Edison Luiz Leismann

    2015-01-01

    This study had as its central objective to ascertain how managers connect with information technology. The methodology applied was an exploratory research, through a structured questionnaire survey based on qualitative and quantitative approach. The study interviewed eighteen managers in a city in Brazil (Cascavel – Paraná), from the industrial segment distributed in several areas, selected by the non-probabilistic method, considering the samples by convenience. The research results showed...

  19. Connected Me - Proof of Concept

    OpenAIRE

    Vajravelu, Dilip Kumar

    2013-01-01

    Connected Me is a Human Body Communication (HBC) system, which is used fortransferring data through human body. The working principle is based on theorycalled Body Coupled Communication (BCC), which uses electrostatic couplingfor transferring data between device and human body. Capacitance between bodyand electrode acts as an electrical interface between devices. BCC has become aprominent research area in the field of Personal Area Network (PAN), introducedby Zimmerman in 1995. Until now ther...

  20. Stochastically excited oscillations on the upper main sequence

    DEFF Research Database (Denmark)

    Antoci, Victoria

    2013-01-01

    Convective envelopes in stars on the main sequence are usually connected only with stars of spectral types F5 or later. However, observations as well as theory indicate that the convective outer layers in earlier stars, despite being shallow, are still effective and turbulent enough to stochastic......Convective envelopes in stars on the main sequence are usually connected only with stars of spectral types F5 or later. However, observations as well as theory indicate that the convective outer layers in earlier stars, despite being shallow, are still effective and turbulent enough...... to stochastically excite oscillations. Because of the low amplitudes, exploring stochastically excited pulsations became possible only with space missions such as Kepler and CoRoT. Here I review the recent results and discuss among others, pulsators such as delta Scuti, gamma Doradus, roAp, beta Cephei, Slowly...... Pulsating B and Be stars, all in the context of solar-like oscillations....

  1. Networks that learn the precise timing of event sequences.

    Science.gov (United States)

    Veliz-Cuba, Alan; Shouval, Harel Z; Josić, Krešimir; Kilpatrick, Zachary P

    2015-12-01

    Neuronal circuits can learn and replay firing patterns evoked by sequences of sensory stimuli. After training, a brief cue can trigger a spatiotemporal pattern of neural activity similar to that evoked by a learned stimulus sequence. Network models show that such sequence learning can occur through the shaping of feedforward excitatory connectivity via long term plasticity. Previous models describe how event order can be learned, but they typically do not explain how precise timing can be recalled. We propose a mechanism for learning both the order and precise timing of event sequences. In our recurrent network model, long term plasticity leads to the learning of the sequence, while short term facilitation enables temporally precise replay of events. Learned synaptic weights between populations determine the time necessary for one population to activate another. Long term plasticity adjusts these weights so that the trained event times are matched during playback. While we chose short term facilitation as a time-tracking process, we also demonstrate that other mechanisms, such as spike rate adaptation, can fulfill this role. We also analyze the impact of trial-to-trial variability, showing how observational errors as well as neuronal noise result in variability in learned event times. The dynamics of the playback process determines how stochasticity is inherited in learned sequence timings. Future experiments that characterize such variability can therefore shed light on the neural mechanisms of sequence learning.

  2. HIV protein sequence hotspots for crosstalk with host hub proteins.

    Directory of Open Access Journals (Sweden)

    Mahdi Sarmady

    Full Text Available HIV proteins target host hub proteins for transient binding interactions. The presence of viral proteins in the infected cell results in out-competition of host proteins in their interaction with hub proteins, drastically affecting cell physiology. Functional genomics and interactome datasets can be used to quantify the sequence hotspots on the HIV proteome mediating interactions with host hub proteins. In this study, we used the HIV and human interactome databases to identify HIV targeted host hub proteins and their host binding partners (H2. We developed a high throughput computational procedure utilizing motif discovery algorithms on sets of protein sequences, including sequences of HIV and H2 proteins. We identified as HIV sequence hotspots those linear motifs that are highly conserved on HIV sequences and at the same time have a statistically enriched presence on the sequences of H2 proteins. The HIV protein motifs discovered in this study are expressed by subsets of H2 host proteins potentially outcompeted by HIV proteins. A large subset of these motifs is involved in cleavage, nuclear localization, phosphorylation, and transcription factor binding events. Many such motifs are clustered on an HIV sequence in the form of hotspots. The sequential positions of these hotspots are consistent with the curated literature on phenotype altering residue mutations, as well as with existing binding site data. The hotspot map produced in this study is the first global portrayal of HIV motifs involved in altering the host protein network at highly connected hub nodes.

  3. Inferring Neuronal Network Connectivity using Time-constrained Episodes

    CERN Document Server

    Patnaik, Debprakash; Unnikrishnan, K P

    2007-01-01

    Discovering frequent episodes in event sequences is an interesting data mining task. In this paper, we argue that this framework is very effective for analyzing multi-neuronal spike train data. Analyzing spike train data is an important problem in neuroscience though there are no data mining approaches reported for this. Motivated by this application, we introduce different temporal constraints on the occurrences of episodes. We present algorithms for discovering frequent episodes under temporal constraints. Through simulations, we show that our method is very effective for analyzing spike train data for unearthing underlying connectivity patterns.

  4. Allele Re-sequencing Technologies

    DEFF Research Database (Denmark)

    Byrne, Stephen; Farrell, Jacqueline Danielle; Asp, Torben

    2013-01-01

    The development of next-generation sequencing technologies has made sequencing an affordable approach for detection of genetic variations associated with various traits. However, the cost of whole genome re-sequencing still remains too high to be feasible for many plant species with large and com...... alternative to whole genome re-sequencing to identify causative genetic variations in plants. One challenge, however, will be efficient bioinformatics strategies for data handling and analysis from the increasing amount of sequence information.......The development of next-generation sequencing technologies has made sequencing an affordable approach for detection of genetic variations associated with various traits. However, the cost of whole genome re-sequencing still remains too high to be feasible for many plant species with large...

  5. Spaces of Ideal Convergent Sequences

    Directory of Open Access Journals (Sweden)

    M. Mursaleen

    2014-01-01

    Full Text Available In the present paper, we introduce some sequence spaces using ideal convergence and Musielak-Orlicz function ℳ=Mk. We also examine some topological properties of the resulting sequence spaces.

  6. Vortex generated fluid flows in multiply connected domains

    CERN Document Server

    Zemlyanova, Anna; Handley, Demond

    2016-01-01

    A fluid flow in a multiply connected domain generated by an arbitrary number of point vortices is considered. A stream function for this flow is constructed as a limit of a certain functional sequence using the method of images. The convergence of this sequence is discussed, and the speed of convergence is determined explicitly. The presented formulas allow for the easy computation of the values of the stream function with arbitrary precision in the case of well-separated cylinders. The considered problem is important for applications such as eddy flows in the oceans. Moreover, since finding the stream function of the flow is essentially identical to finding the modified Green's function for Laplace's equation, the presented method can be applied to a more general class of applied problems which involve solving the Dirichlet problem for Laplace's equation.

  7. Novel sequences propel familiar folds.

    Science.gov (United States)

    Jawad, Zahra; Paoli, Massimo

    2002-04-01

    Recent structure determinations have made new additions to a set of strikingly different sequences that give rise to the same topology. Proteins with a beta propeller fold are characterized by extreme sequence diversity despite the similarity in their three-dimensional structures. Several fold predictions, based in part on sequence repeats thought to match modular beta sheets, have been proved correct.

  8. Sequencing Games with Repeated Players

    NARCIS (Netherlands)

    Estevez Fernandez, M.A.; Borm, P.E.M.; Calleja, P.; Hamers, H.J.M.

    2004-01-01

    Two classes of one machine sequencing situations are considered in which each job corresponds to exactly one player but a player may have more than one job to be processed, so called RP(repeated player) sequencing situations.In max-RP sequencing situations it is assumed that each player's cost funct

  9. Rapid Polymer Sequencer

    Science.gov (United States)

    Stolc, Viktor (Inventor); Brock, Matthew W (Inventor)

    2013-01-01

    Method and system for rapid and accurate determination of each of a sequence of unknown polymer components, such as nucleic acid components. A self-assembling monolayer of a selected substance is optionally provided on an interior surface of a pipette tip, and the interior surface is immersed in a selected liquid. A selected electrical field is impressed in a longitudinal direction, or in a transverse direction, in the tip region, a polymer sequence is passed through the tip region, and a change in an electrical current signal is measured as each polymer component passes through the tip region. Each of the measured changes in electrical current signals is compared with a database of reference electrical change signals, with each reference signal corresponding to an identified polymer component, to identify the unknown polymer component with a reference polymer component. The nanopore preferably has a pore inner diameter of no more than about 40 nm and is prepared by heating and pulling a very small section of a glass tubing.

  10. The Galaxy End Sequence

    CERN Document Server

    Eales, Stephen; Smith, Matthew; Appah, Kiran; Ciesla, Laure; Duffield, Chris; Schofield, Simon

    2016-01-01

    A common assumption is that galaxies fall in two distinct regions on a plot of specific star-formation rate (SSFR) versus galaxy stellar mass: a star-forming Galaxy Main Sequence (GMS) and a separate region of `passive' or `red and dead galaxies'. Starting from a volume-limited sample of nearby galaxies designed to contain most of the stellar mass in this volume, and thus being a fair representation of the Universe at the end of 12 billion years of galaxy evolution, we investigate the distribution of galaxies in this diagram today. We show that galaxies follow a strongly curved extended GMS with a steep negative slope at high galaxy stellar masses. There is a gradual change in the morphologies of the galaxies along this distribution, but there is no clear break between early-type and late-type galaxies. Examining the other evidence that there are two distinct populations, we argue that the `red sequence' is the result of the colours of galaxies changing very little below a critical value of the SSFR, rather t...

  11. MOHCS: Towards Mining Overlapping Highly Connected Subgraphs

    CERN Document Server

    Lin, Xiahong; Chen, Kefei; Chiu, David K Y

    2008-01-01

    Many networks in real-life typically contain parts in which some nodes are more highly connected to each other than the other nodes of the network. The collection of such nodes are usually called clusters, communities, cohesive groups or modules. In graph terminology, it is called highly connected graph. In this paper, we first prove some properties related to highly connected graph. Based on these properties, we then redefine the highly connected subgraph which results in an algorithm that determines whether a given graph is highly connected in linear time. Then we present a computationally efficient algorithm, called MOHCS, for mining overlapping highly connected subgraphs. We have evaluated experimentally the performance of MOHCS using real and synthetic data sets from computer-generated graph and yeast protein network. Our results show that MOHCS is effective and reliable in finding overlapping highly connected subgraphs. Keywords-component; Highly connected subgraph, clustering algorithms, minimum cut, m...

  12. Connecting Related Rates and Differential Equations

    Science.gov (United States)

    Brandt, Keith

    2012-01-01

    This article points out a simple connection between related rates and differential equations. The connection can be used for in-class examples or homework exercises, and it is accessible to students who are familiar with separation of variables.

  13. Linear connections on the quantum plane

    OpenAIRE

    Dubois-Violette, Michel; Madore, John; Masson, Thierry; Mourad, Jihad

    1994-01-01

    A general definition has been proposed recently of a linear connection and a metric in noncommutative geometry. It is shown that to within normalization there is a unique linear connection on the quantum plane and there is no metric.

  14. Strategy of Concurrent Optimization for an Assembly Sequence

    Institute of Scientific and Technical Information of China (English)

    YANG Bo; LIU Lu-ning; ZE Xiang-bo

    2005-01-01

    An effective constraint release based approach to realize concurrent optimization for an assembly sequence is proposed. To quantify the measurement of assembly efficiency, a mathematical model of concurrency evaluation index was put forward at first, and then a technology to quantify assembly constraints was developed by application of some fuzzy logic algorithms. In the process of concurrent optimization of the assembly sequence, two kinds of constraints were involved. One was self-constraints of components, which was used to evaluate the assemble capability of components under the condition of full-freedom. Another was an assembly constraint between components represented by geometric constraints between points, lines and planes under physical restriction conditions. The concept of connection strength degree (CSD) was introduced as one efficient indicator and the value of it was evaluated by the intersection of the two constraints mentioned above. The equivalent constraints describing the connection weights between components were realized by a well designed constraints reduction, and then the connection weights based complete assembly liaison graph was applied to release virtual connections between components. Under a given threshold value, a decomposition and reconstituting strategy for the graph with the focus on high assembly concurrency was used to realize an optimized assembly concurrency evaluation index. Finally, the availability of the approach was illustrated in an example to optimize the assembly of a shift pump.

  15. Embedded adhesive connection for laminated glass plates

    DEFF Research Database (Denmark)

    Hansen, Jens Zangenberg; Poulsen, S.H.; Bagger, A.;

    2012-01-01

    The structural behavior of a new connection design, the embedded adhesive connection, used for laminated glass plates is investigated. The connection consists of an aluminum plate encapsulated in-between two adjacent triple layered laminated glass plates. Fastening between glass and aluminum...... usage in a design situation. The embedded connection shows promising potential as a future fastening system for load-carrying laminated glass plates....

  16. Fatigue Assessment of Threaded Riser Connections

    OpenAIRE

    Braun, Moritz,

    2014-01-01

    Threaded connections as found in applications like rigid riser, drillstrings, and workover riser are manufactured with sharp notches. Subjected to cyclic loading, those notches lead to high stress concentrations, which increase the risk of fatigue crack initiation significantly. A common connection type that has been the basis for extensive studies is the API Line Pipe connection. The basic API thread type consists of truncated triangular threads. In order to tighten the connection the male a...

  17. Destination Sequenced – Distance Vector Algorithm

    Directory of Open Access Journals (Sweden)

    Anto Ramya. S. I

    2015-11-01

    Full Text Available Mobile Ad Hoc Network (MANET is an infrastructure where nodes communicate without any central administration. Nodes are connected through wireless channels and can use multiple hops to exchange data. Routing protocols are needed for communication in such networks. Each node acts both as a router and host concurrently, which can move out or join the network freely. The instantly created network does not have any base infrastructure as used in conventional networks, but it is compatible with conventional networks. This paper discusses about the Destination – Sequenced Distance Vector (DSDV which is a modification of the conventional Bellman-Ford routing algorithm. It addresses the drawbacks related to the poor looping properties of Routing Information Protocol (RIP in the face of broken links. The modification adapted in DSDV makes it more suitable routing protocol for MANETs. This paper discusses about the DSDV protocol and analyses the properties of DSDV when it is used for MANET routing.

  18. Connectivity in Autism: A review of MRI connectivity studies

    Science.gov (United States)

    Rane, Pallavi; Cochran, David; Hodge, Steven M.; Haselgrove, Christian; Kennedy, David; Frazier, Jean A.

    2016-01-01

    Autism Spectrum Disorder (ASD) affects 1 in 50 children between the ages of 6–17 years as per a 2012 CDC survey of parents. The etiology of ASD is not precisely known. ASD is an umbrella term, which includes low (IQ70) individuals. A better understanding of the disorder, and how it manifests in an individual subject can lead to more effective intervention plans to fulfill the individual’s treatment needs. Magnetic resonance imaging (MRI) is a non-invasive investigational tool that can help study the ways in which the brain develops and/or deviates from the typical developmental trajectory. MRI offers insights into the structure, function, and metabolism of the brain. In this article, we review published studies on brain connectivity changes in ASD using either resting state functional MRI or diffusion tensor imaging. The general findings of decreases in white matter integrity and long-range neural coherence are prevalent in ASD literature. However, there is somewhat less of a consensus in the detailed localization of these findings. There are even fewer studies linking these connectivity alterations with the behavioral phenotype of the disorder. Nevertheless, with the help of data sharing and large-scale analytic efforts, the field is advancing towards several convergent themes. These include reduced functional coherence of long-range intra-hemispheric cortico-cortical default mode circuitry, impaired inter-hemispheric regulation, and an associated, perhaps compensatory, increase in local and short-range cortico-subcortical coherence. PMID:26146755

  19. 46 CFR 64.33 - Pipe connection.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Pipe connection. 64.33 Section 64.33 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING MARINE PORTABLE TANKS AND CARGO HANDLING SYSTEMS Standards for an MPT § 64.33 Pipe connection. Each pipe connection that is not a...

  20. Perfusion deficits and functional connectivity alterations in patients with post-traumatic stress disorder

    Science.gov (United States)

    Liu, Yang; Li, Baojuan; Zhang, Xi; Zhang, Linchuan; Li, Liang; Lu, Hongbing

    2016-03-01

    To explore the alteration in cerebral blood flow (CBF) and functional connectivity between survivors with recent onset post-traumatic stress disorder (PTSD) and without PTSD, survived from the same coal mine flood disaster. In this study, a processing pipeline using arterial spin labeling (ASL) sequence was proposed. Considering low spatial resolution of ASL sequence, a linear regression method was firstly used to correct the partial volume (PV) effect for better CBF estimation. Then the alterations of CBF between two groups were analyzed using both uncorrected and PV-corrected CBF maps. Based on altered CBF regions detected from the CBF analysis as seed regions, the functional connectivity abnormities in PTSD patients was investigated. The CBF analysis using PV-corrected maps indicates CBF deficits in the bilateral frontal lobe, right superior frontal gyrus and right corpus callosum of PTSD patients, while only right corpus callosum was identified in uncorrected CBF analysis. Furthermore, the regional CBF of the right superior frontal gyrus exhibits significantly negative correlation with the symptom severity in PTSD patients. The resting-state functional connectivity indicates increased connectivity between left frontal lobe and right parietal lobe. These results indicate that PV-corrected CBF exhibits more subtle perfusion changes and may benefit further perfusion and connectivity analysis. The symptom-specific perfusion deficits and aberrant connectivity in above memory-related regions may be putative biomarkers for recent onset PTSD induced by a single prolonged trauma exposure and help predict the severity of PTSD.

  1. Complete Convergence of Exchangeable Sequences

    Directory of Open Access Journals (Sweden)

    George Stoica

    2011-01-01

    Full Text Available We prove that exchangeable sequences converge completely in the Baum-Katz sense under the same conditions as i.i.d. sequences do. Problem statement: The research was needed as the rate of convergence in the law of large numbers for exchangeable sequences was previously obtained under restricted hypotheses. Approach: We applied powerful techniques involving inequalities for independent sequences of random variables. Results: We obtained the maximal rate of convergence and provided an example to show that our findings are sharp. Conclusion/Recommendations: The technique used in the paper may be adapted in the similar study for identically distributed sequences.

  2. Connectivity Changes in Parkinson's Disease.

    Science.gov (United States)

    Cerasa, Antonio; Novellino, Fabiana; Quattrone, Aldo

    2016-10-01

    Parkinson's disease (PD) is a chronic and progressive movement disorder of the central nervous system characterized by widespread alterations in several non-motor aspects such as mood, sleep, olfactory, and cognition in addition to motor dysfunctions. Advanced neuroimaging using functional connectivity reconstruction of the human brain has provided a vast knowledge on the pathophysiological mechanisms underlying this disorder, but this, however, does not cover the overall inter-/intra-individual variability of PD phenotypes. The present review is aimed at discussing to what extent the evidence provided by group-based neuroimaging analysis in this field of study (using seed-based, network-based, or graph theory approaches) may be generalized. In particular, we summarized the literature on the application of resting-state functional connectivity studies to explore different neural correlates of motor and non-motor symptoms of PD and the neural mechanisms involved in treatment effects: effects of levodopa or deep brain stimulation. The lesson learnt from one decade of studies provides consistent evidence on the role of the altered communication between the striato-frontal pathways as a marker of PD-related motor degeneration, whereas in the non-motor domain, several missing pieces of a complex puzzle are provided. However, the main target is to present a new era of intelligent neuroimaging applications, where automated multivariate analysis of functional connectivity data may be used for moving from group-level statistical results to personalized predictions in a clinical setting. Although in its relative infancy, the evidence gathered so far suggests a new era of clinical neuroimaging is starting. PMID:27568202

  3. Connectivity graphs of uncertainty regions

    CERN Document Server

    Chambers, Erin; Lenchner, Jonathan; Sember, Jeff; Srinivasan, Venkatesh; Stege, Ulrike; Stolpner, Svetlana; Weibel, Christophe; Whitesides, Sue

    2010-01-01

    We study a generalization of the well known bottleneck spanning tree problem called "Best Case Connectivity with Uncertainty": Given a family of geometric regions, choose one point per region, such that the length of the longest edge in a spanning tree of a disc intersection graph is minimized. We show that this problem is NP-hard even for very simple scenarios such as line segments and squares. We also give exact and approximation algorithms for the case of line segments and unit discs respectively.

  4. Women's connectivity in extreme networks.

    Science.gov (United States)

    Manrique, Pedro; Cao, Zhenfeng; Gabriel, Andrew; Horgan, John; Gill, Paul; Qi, Hong; Restrepo, Elvira M; Johnson, Daniela; Wuchty, Stefan; Song, Chaoming; Johnson, Neil

    2016-06-01

    A popular stereotype is that women will play more minor roles than men as environments become more dangerous and aggressive. Our analysis of new longitudinal data sets from offline and online operational networks [for example, ISIS (Islamic State)] shows that although men dominate numerically, women emerge with superior network connectivity that can benefit the underlying system's robustness and survival. Our observations suggest new female-centric approaches that could be used to affect such networks. They also raise questions about how individual contributions in high-pressure systems are evaluated. PMID:27386564

  5. The Cosmology - Particle Physics Connection

    CERN Document Server

    Trodden, M

    2006-01-01

    Modern cosmology poses deep and unavoidable questions for fundamental physics. In this plenary talk, delivered in slightly different forms at the {\\it Particles and Nuclei International Conference} (PANIC05) in Santa Fe, in October 2005, and at the {\\it CMB and Physics of the Early Universe International Conference}, on the island of Ischia, Italy, in April 2006, I discuss the broad connections between cosmology and particle physics, focusing on physics at the TeV scale, accessible at the next and future generations of colliders

  6. Adobe Connect Pro ohjauksen apuna

    OpenAIRE

    Koukkari, Katja

    2010-01-01

    Tämän kehittämistyön tavoitteena on tarkastella, miten suunnittelijat ja opiskelijat kokevat Adobe Connect Pro -ohjelman käytön ohjauksen apuna sekä miten käytettävä ohjelma on sekä teknisesti että pedagogisesti. Teoriaosuudessa tarkastelen mm. sulautuvaa opetusta ja verkko-ohjauksen erityispiirteitä. Internet tarjoaa mahdollisuuksia sekä eriaikaiseen että reaaliaikaiseen viestintään. Perinteisesti verkkokurssin viestintä on ollut eriaikaista tekstipohjaisuuteen perustuvaa viestintää. Nykyisi...

  7. Study of rectenna array connection

    Energy Technology Data Exchange (ETDEWEB)

    Miura, T.; Shinohara, N.; Matsumoto, H. [Kyoto Univ., Uji (Japan). Engineering Research Inst.

    1997-11-01

    A study was conducted in which a new rectenna working at 2.45 GHz microwave was developed for ground-to-ground microwave power transmission. The new rectenna consists of an antenna section and a rectifying section. The new design is simple and therefore more accurate than a micro-strip type patch antenna. The efficiency of conversion of microwave power to direct current depends on the mutual dependence of antenna elements and circuit conditions of rectifying sections. A series of experiments were conducted to analyze the rectenna characteristics and a method for efficiently connecting rectenna arrays was proposed. 3 refs., 2 tabs., 15 figs.

  8. New molecular connections in angiogenesis

    Institute of Scientific and Technical Information of China (English)

    Qiling Xu; David Wilkinson

    2010-01-01

    @@ In vertebrates, oxygen and nutrients are delivered to tissues by the circula-tion of blood through vessels, comprised of a branched network of endothelial tubes termed the vasculature. Crucial for the formation of blood vessels during development is the process of angiogenesis, in which new sprouts form from pre-existing vessels in a complex cascade of cellular events. This involves the activation of an endothelial cell in the vessel to become a highly exploratory 'tip' cell that migrates to invade the surrounding tissues, while remaining tightly connected to the fol-lowing cells that subsequently generate the tubular structures of a new vessel.

  9. A Building Connecting Separated Communities

    DEFF Research Database (Denmark)

    Axel, Erik

    abroad was constructed by different professional groups architects/engineers/craft persons, and how it was used by some groupings of students. In the beginning of the construction process our interviews with the architects revealed that the architect designing the house collaborated with an architect...... with students from other dormitories, and connect with the Danes from other sections of the building isolating themselves. The janitor was surprised at the supposed function of the washing machines. Since other dormitories at the campus did not provide washing machines, the ones at the house investigated were...

  10. Solid phase sequencing of biopolymers

    Energy Technology Data Exchange (ETDEWEB)

    Cantor, Charles (Del Mar, CA); Koster, Hubert (La Jolla, CA)

    2010-09-28

    This invention relates to methods for detecting and sequencing target nucleic acid sequences, to mass modified nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involve hybridizing the nucleic acids or nucleic acids which represent complementary or homologous sequences of the target to an array of nucleic acid probes. These probes comprise a single-stranded portion, an optional double-stranded portion and a variable sequence within the single-stranded portion. The molecular weights of the hybridized nucleic acids of the set can be determined by mass spectroscopy, and the sequence of the target determined from the molecular weights of the fragments. Nucleic acids whose sequences can be determined include DNA or RNA in biological samples such as patient biopsies and environmental samples. Probes may be fixed to a solid support such as a hybridization chip to facilitate automated molecular weight analysis and identification of the target sequence.

  11. The Evolution of Nanopore Sequencing

    Directory of Open Access Journals (Sweden)

    Yue eWang

    2015-01-01

    Full Text Available The $1,000 Genome project has been drawing increasing attention since its launch a decade ago. Nanopore sequencing, the third-generation, is believed to be one of the most promising sequencing technologies to reach four gold standards set for the $1,000 Genome while the second-generation sequencing technologies are bringing about a revolution in life sciences, particularly in genome sequencing-based personalized medicine. Both of protein and solid-state nanopores have been extensively investigated for a series of issues, from detection of ionic current blockage to field-effect-transistor (FET sensors. A newly released protein nanopore sequencer has shown encouraging potential that nanopore sequencing will ultimately fulfill the gold standards. In this review, we address advances, challenges, and possible solutions of nanopore sequencing according to these standards.

  12. Connection method of separated luminal regions of intestine from CT volumes

    Science.gov (United States)

    Oda, Masahiro; Kitasaka, Takayuki; Furukawa, Kazuhiro; Watanabe, Osamu; Ando, Takafumi; Hirooka, Yoshiki; Goto, Hidemi; Mori, Kensaku

    2015-03-01

    This paper proposes a connection method of separated luminal regions of the intestine for Crohn's disease diagnosis. Crohn's disease is an inflammatory disease of the digestive tract. Capsule or conventional endoscopic diagnosis is performed for Crohn's disease diagnosis. However, parts of the intestines may not be observed in the endoscopic diagnosis if intestinal stenosis occurs. Endoscopes cannot pass through the stenosed parts. CT image-based diagnosis is developed as an alternative choice of the Crohn's disease. CT image-based diagnosis enables physicians to observe the entire intestines even if stenosed parts exist. CAD systems for Crohn's disease using CT volumes are recently developed. Such CAD systems need to reconstruct separated luminal regions of the intestines to analyze intestines. We propose a connection method of separated luminal regions of the intestines segmented from CT volumes. The luminal regions of the intestines are segmented from a CT volume. The centerlines of the luminal regions are calculated by using a thinning process. We enumerate all the possible sequences of the centerline segments. In this work, we newly introduce a condition using distance between connected ends points of the centerline segments. This condition eliminates unnatural connections of the centerline segments. Also, this condition reduces processing time. After generating a sequence list of the centerline segments, the correct sequence is obtained by using an evaluation function. We connect the luminal regions based on the correct sequence. Our experiments using four CT volumes showed that our method connected 6.5 out of 8.0 centerline segments per case. Processing times of the proposed method were reduced from the previous method.

  13. Logging Data High-Resolution Sequence Stratigraphy

    Institute of Scientific and Technical Information of China (English)

    Li Hongqi; Xie Yinfu; Sun Zhongchun; Luo Xingping

    2006-01-01

    The recognition and contrast of bed sets in parasequence is difficult in terrestrial basin high-resolution sequence stratigraphy. This study puts forward new methods for the boundary identification and contrast of bed sets on the basis of manifold logging data. The formation of calcareous interbeds, shale resistivity differences and the relation of reservoir resistivity to altitude are considered on the basis of log curve morphological characteristics, core observation, cast thin section, X-ray diffraction and scanning electron microscopy. The results show that the thickness of calcareous interbeds is between 0.5 m and 2 m, increasing on weathering crusts and faults. Calcareous interbeds occur at the bottom of Reservoir resistivity increases with altitude. Calcareous interbeds may be a symbol of recognition for the boundary of bed sets and isochronous contrast bed sets, and shale resistivity differences may confirm the stack relation and connectivity of bed sets. Based on this, a high-rcsolution chronostratigraphic framework of Xi-1 segment in Shinan area, Junggar basin is presented, and the connectivity of bed sets and oil-water contact is confirmed. In this chronostratigraphic framework, the growth order, stack mode and space shape of bed sets are qualitatively and quantitatively described.

  14. Behavior of concentrically loaded CFT braces connections

    Directory of Open Access Journals (Sweden)

    Maha M. Hassan

    2014-03-01

    Full Text Available Concrete filled tubes (CFTs composite columns have many economical and esthetic advantages, but the behavior of their connections is complicated. Through this study, it is aimed to investigate the performance and behavior of different connection configurations between concrete filled steel tube columns and bracing diagonals through an experimental program. The study included 12 connection subassemblies consisting of a fixed length steel tube and gusset plate connected to the tube end with different details tested under half cyclic loading. A notable effect was observed on the behavior of the connections due to its detailing changes with respect to capacity, failure mode, ductility, and stress distribution.

  15. Making connections: reflection, feedback and support

    Directory of Open Access Journals (Sweden)

    Jane Seale

    2007-12-01

    Full Text Available Hansell (1974 conceptualized seven different connections or attachments that we have to the world in which we live: attachments that consist of connections to other people, to a social role as well as to a system of meaning. For many, learning is at the heart of the process of making connections, particularly meaningful connections (Horton, 2000. If this is true, then it leads us to consider the extent to which educators, the systems they work in and the tools they use have a role to play in helping learners make those meaningful connections. For example, Scherer (2002, p. 5 suggests that educational systems have a responsibility to:

  16. Generalized magnetofluid connections in relativistic magnetohydrodynamics.

    Science.gov (United States)

    Asenjo, Felipe A; Comisso, Luca

    2015-03-20

    The concept of magnetic connections is extended to nonideal relativistic magnetohydrodynamical plasmas. Adopting a general set of equations for relativistic magnetohydrodynamics including thermal-inertial, thermal electromotive, Hall, and current-inertia effects, we derive a new covariant connection equation showing the existence of generalized magnetofluid connections that are preserved during the dissipationless plasma dynamics. These connections are intimately linked to a general antisymmetric tensor that unifies the electromagnetic and fluid fields, allowing the extension of the magnetic connection notion to a much broader concept. PMID:25839284

  17. Generalized magnetofluid connections in pair plasmas

    International Nuclear Information System (INIS)

    We extend the magnetic connection theorem of ideal magnetohydrodynamics to nonideal relativistic pair plasmas. Adopting a generalized Ohm's law, we prove the existence of generalized magnetofluid connections that are preserved by the plasma dynamics. We show that these connections are related to a general antisymmetric tensor that unifies the electromagnetic and fluid fields. The generalized magnetofluid connections set important constraints on the plasma dynamics by forbidding transitions between configurations with different magnetofluid connectivity. An approximated solution is explicitly shown where the corrections due to current inertial effects are found

  18. Generalized magnetofluid connections in pair plasmas

    Science.gov (United States)

    Asenjo, Felipe A.; Comisso, Luca; Mahajan, Swadesh M.

    2015-12-01

    We extend the magnetic connection theorem of ideal magnetohydrodynamics to nonideal relativistic pair plasmas. Adopting a generalized Ohm's law, we prove the existence of generalized magnetofluid connections that are preserved by the plasma dynamics. We show that these connections are related to a general antisymmetric tensor that unifies the electromagnetic and fluid fields. The generalized magnetofluid connections set important constraints on the plasma dynamics by forbidding transitions between configurations with different magnetofluid connectivity. An approximated solution is explicitly shown where the corrections due to current inertial effects are found.

  19. Generalized Magnetofluid Connections in Pair Plasmas

    CERN Document Server

    Asenjo, Felipe A; Mahajan, Swadesh M

    2015-01-01

    We extend the magnetic connection theorem of ideal magnetohydrodynamics to nonideal relativistic pair plasmas. Adopting a generalized Ohm's law, we prove the existence of generalized magnetofluid connections that are preserved by the plasma dynamics. We show that these connections are related to a general antisymmetric tensor that unifies the electromagnetic and fluid fields. The generalized magnetofluid connections set important constraints on the plasma dynamics by forbidding transitions between configurations with different magnetofluid connectivity. An approximated solution is explicitly shown where the corrections due to current inertial effects are found.

  20. Generalized magnetofluid connections in pair plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Asenjo, Felipe A., E-mail: felipe.asenjo@uai.cl [Facultad de Ingeniería y Ciencias, Universidad Adolfo Ibáñez, Santiago 7941169 (Chile); Comisso, Luca, E-mail: lcomisso@princeton.edu [Department of Astrophysical Sciences and Princeton Plasma Physics Laboratory, Princeton University, Princeton, New Jersey 08544 (United States); Dipartimento Energia, Politecnico di Torino, Torino 10129, Italy and Istituto dei Sistemi Complessi-CNR, Roma 00185 (Italy); Mahajan, Swadesh M., E-mail: mahajan@mail.utexas.edu [Institute for Fusion Studies, The University of Texas at Austin, Austin, Texas 78712 (United States)

    2015-12-15

    We extend the magnetic connection theorem of ideal magnetohydrodynamics to nonideal relativistic pair plasmas. Adopting a generalized Ohm's law, we prove the existence of generalized magnetofluid connections that are preserved by the plasma dynamics. We show that these connections are related to a general antisymmetric tensor that unifies the electromagnetic and fluid fields. The generalized magnetofluid connections set important constraints on the plasma dynamics by forbidding transitions between configurations with different magnetofluid connectivity. An approximated solution is explicitly shown where the corrections due to current inertial effects are found.

  1. Connectivity editing for quadrilateral meshes

    KAUST Repository

    Peng, Chihan

    2011-12-12

    We propose new connectivity editing operations for quadrilateral meshes with the unique ability to explicitly control the location, orientation, type, and number of the irregular vertices (valence not equal to four) in the mesh while preserving sharp edges. We provide theoretical analysis on what editing operations are possible and impossible and introduce three fundamental operations to move and re-orient a pair of irregular vertices. We argue that our editing operations are fundamental, because they only change the quad mesh in the smallest possible region and involve the fewest irregular vertices (i.e., two). The irregular vertex movement operations are supplemented by operations for the splitting, merging, canceling, and aligning of irregular vertices. We explain how the proposed highlevel operations are realized through graph-level editing operations such as quad collapses, edge flips, and edge splits. The utility of these mesh editing operations are demonstrated by improving the connectivity of quad meshes generated from state-of-art quadrangulation techniques. © 2011 ACM.

  2. Connectivity editing for quadrilateral meshes

    KAUST Repository

    Peng, Chihan

    2011-12-01

    We propose new connectivity editing operations for quadrilateral meshes with the unique ability to explicitly control the location, orientation, type, and number of the irregular vertices (valence not equal to four) in the mesh while preserving sharp edges. We provide theoretical analysis on what editing operations are possible and impossible and introduce three fundamental operations to move and re-orient a pair of irregular vertices. We argue that our editing operations are fundamental, because they only change the quad mesh in the smallest possible region and involve the fewest irregular vertices (i.e., two). The irregular vertex movement operations are supplemented by operations for the splitting, merging, canceling, and aligning of irregular vertices. We explain how the proposed high-level operations are realized through graph-level editing operations such as quad collapses, edge flips, and edge splits. The utility of these mesh editing operations are demonstrated by improving the connectivity of quad meshes generated from state-of-art quadrangulation techniques.

  3. Astrophysicists' conversational connections on Twitter.

    Directory of Open Access Journals (Sweden)

    Kim Holmberg

    Full Text Available Because Twitter and other social media are increasingly used for analyses based on altmetrics, this research sought to understand what contexts, affordance use, and social activities influence the tweeting behavior of astrophysicists. Thus, the presented study has been guided by three research questions that consider the influence of astrophysicists' activities (i.e., publishing and tweeting frequency and of their tweet construction and affordance use (i.e. use of hashtags, language, and emotions on the conversational connections they have on Twitter. We found that astrophysicists communicate with a variety of user types (e.g. colleagues, science communicators, other researchers, and educators and that in the ego networks of the astrophysicists clear groups consisting of users with different professional roles can be distinguished. Interestingly, the analysis of noun phrases and hashtags showed that when the astrophysicists address the different groups of very different professional composition they use very similar terminology, but that they do not talk to each other (i.e. mentioning other user names in tweets. The results also showed that in those areas of the ego networks that tweeted more the sentiment of the tweets tended to be closer to neutral, connecting frequent tweeting with information sharing activities rather than conversations or expressing opinions.

  4. Content, Context & Connectivity Persuasive Interplay

    DEFF Research Database (Denmark)

    Sørensen, Christian Grund

    2013-01-01

    The aim of this paper is to discuss the relationship between content, context and connectivity and suggesting a model of Dynamic Interplay. This is done in relation to a specific learning environment concerning cultural mediation, in casu the Kaj Munk Case of the EuroPLOT-project (an EU-supported......The aim of this paper is to discuss the relationship between content, context and connectivity and suggesting a model of Dynamic Interplay. This is done in relation to a specific learning environment concerning cultural mediation, in casu the Kaj Munk Case of the EuroPLOT-project (an EU...... is discussed. Focus is here on The Kaj Munk Study Edition, The Conceptual Pond, Immersive Layers Design, and Generative Learning Objects (GLOs) which are applications affiliated with the Munk case. This paper explores the persuasive potential of the interplay between the different applications for the benefit...... of learning and reflection and a model of Dynamic Interplay is introduced. This is done with a primary inspiration from rhetoric particularly in the shape of the Aptum model and a focus on kairos. Possible benefits of this approach are discussed and several questions for further research are suggested....

  5. Dynamical decoupling sequence construction as a filter-design problem

    Science.gov (United States)

    Biercuk, M. J.; Doherty, A. C.; Uys, H.

    2011-08-01

    Over the past decade we have seen an explosion of demonstrations of quantum coherence in atomic, optical and condensed matter systems. These developments have placed a new emphasis on the production of robust and optimal quantum control techniques in the presence of environmental noise. We discuss the use of dynamical decoupling as a form of open-loop quantum control capable of suppressing the effects of dephasing in quantum coherent systems. We introduce the concept of dynamical decoupling pulse-sequence construction as a filter-design problem, making connections with filter design from control theory and electrical engineering in the analysis of pulse-sequence performance for the preservation of the phase degree of freedom in a quantum superposition. A detailed mathematical description of how dephasing and its suppression can be reduced to a linear control problem is provided, and used as motivation and context for studies of the filtration properties of various dynamical decoupling sequences. Our work then takes this practical perspective in addressing both 'standard' sequences derived from nuclear magnetic resonance and novel optimized sequences developed in the context of quantum information. Additionally, we review new techniques for the numerical construction of optimized pulse sequences in this light. We show how the filter-design perspective permits concise comparisons of the relative capabilities of these sequences and reveals the physics underlying their functionality. The use of this new analytical framework allows us to derive new insights into the performance of these sequences and reveals important limiting issues, such as the effect of digital clocking on optimized sequence performance.

  6. Investigation into Methods for Predicting Connection Temperatures

    Directory of Open Access Journals (Sweden)

    K. Anderson

    2009-01-01

    Full Text Available The mechanical response of connections in fire is largely based on material strength degradation and the interactions between the various components of the connection. In order to predict connection performance in fire, temperature profiles must initially be established in order to evaluate the material strength degradation over time. This paper examines two current methods for predicting connection temperatures: The percentage method, where connection temperatures are calculated as a percentage of the adjacent beam lower-flange, mid-span temperatures; and the lumped capacitance method, based on the lumped mass of the connection. Results from the percentage method do not correlate well with experimental results, whereas the lumped capacitance method shows much better agreement with average connection temperatures. A 3D finite element heat transfer model was also created in Abaqus, and showed good correlation with experimental results. 

  7. Random geometric graphs with general connection functions

    Science.gov (United States)

    Dettmann, Carl P.; Georgiou, Orestis

    2016-03-01

    In the original (1961) Gilbert model of random geometric graphs, nodes are placed according to a Poisson point process, and links formed between those within a fixed range. Motivated by wireless ad hoc networks "soft" or "probabilistic" connection models have recently been introduced, involving a "connection function" H (r ) that gives the probability that two nodes at distance r are linked (directly connect). In many applications (not only wireless networks), it is desirable that the graph is connected; that is, every node is linked to every other node in a multihop fashion. Here the connection probability of a dense network in a convex domain in two or three dimensions is expressed in terms of contributions from boundary components for a very general class of connection functions. It turns out that only a few quantities such as moments of the connection function appear. Good agreement is found with special cases from previous studies and with numerical simulations.

  8. STRENGTH DESIGN OF PREMIUM THREADED CASING CONNECTION

    Institute of Scientific and Technical Information of China (English)

    Gao Lianxin; Jin Ye; Zhang Yi

    2004-01-01

    Using premium casing connections instead of API ones is one of the most effective technique to prevent casing failure.The factors contribute to the strength of premium casing connections are studied with FEA and full-scale test.The criterions are presented that ensure the connection's strength higher than the pipe.At the same time, the method is given to decrease the peak stress of the connection so as to improve its anticorruption property.At last, full-scale tests are done to test the strength of the connections designed with the method described, the results show that the connection's strength is higher than the pipe.This indicated that the method described is effective in designing premium casing connection.

  9. Block Iterative Eigensolvers for Sequences of Correlated Eigenvalue Problems

    CERN Document Server

    Di Napoli, Edoardo

    2012-01-01

    In Density Functional Theory simulations based on the LAPW method, each self-consistent cycle comprises dozens of large dense generalized eigenproblems. In contrast to real-space methods, eigenpairs solving for problems at distinct cycles have either been believed to be independent or at most very loosely connected. In a recent study \\cite{DBB}, it was proposed to revert this point of view and consider simulations as made of dozens of sequences of eigenvalue problems; each sequence groups together eigenproblems with equal {\\bf k}-vectors and an increasing outer-iteration cycle index $\\ell$. From this different standpoint it was possible to demonstrate that, contrary to belief, successive eigenproblems in a sequence are strongly correlated with one another. In particular, by tracking the evolution of subspace angles between eigenvectors of successive eigenproblems, it was shown that these angles decrease noticeably after the first few iterations and become close to collinear: the closer to convergence the stro...

  10. Universal sequence map (USM of arbitrary discrete sequences

    Directory of Open Access Journals (Sweden)

    Almeida Jonas S

    2002-02-01

    Full Text Available Abstract Background For over a decade the idea of representing biological sequences in a continuous coordinate space has maintained its appeal but not been fully realized. The basic idea is that any sequence of symbols may define trajectories in the continuous space conserving all its statistical properties. Ideally, such a representation would allow scale independent sequence analysis – without the context of fixed memory length. A simple example would consist on being able to infer the homology between two sequences solely by comparing the coordinates of any two homologous units. Results We have successfully identified such an iterative function for bijective mappingψ of discrete sequences into objects of continuous state space that enable scale-independent sequence analysis. The technique, named Universal Sequence Mapping (USM, is applicable to sequences with an arbitrary length and arbitrary number of unique units and generates a representation where map distance estimates sequence similarity. The novel USM procedure is based on earlier work by these and other authors on the properties of Chaos Game Representation (CGR. The latter enables the representation of 4 unit type sequences (like DNA as an order free Markov Chain transition table. The properties of USM are illustrated with test data and can be verified for other data by using the accompanying web-based tool:http://bioinformatics.musc.edu/~jonas/usm/. Conclusions USM is shown to enable a statistical mechanics approach to sequence analysis. The scale independent representation frees sequence analysis from the need to assume a memory length in the investigation of syntactic rules.

  11. Dual Authentication For Bluetooth Connection

    Directory of Open Access Journals (Sweden)

    Diallo Alhassane Saliou

    2014-07-01

    Full Text Available Recently, Bluetooth technology is widely used by organizations and individuals to provide wireless personal area network (WPAN. This is because the radio frequency (RF waves can easily penetrate obstacles and can propagate without direct line-of-sight (LoS. These two characteristics have led to replace wired communication by wireless systems. However, there are serious security challenges associated with wireless communication systems because they are easier to eavesdrop, disrupt and jam than the wired systems. Bluetooth technology started with a form of pairing called legacy pairing prior to any communication. However, due to the serious security issues found in the legacy pairing, a secure and simple pairing called SPP was announced with Bluetooth 2.1 and later since 2007. SPP has solved the main security issue which is the weaknesses of the PIN code in the legacy pairing, however it has been found with some vulnerabilities such as eavesdropping and man-in-the-middle (MITM attacks. Since the discovery of these vulnerabilities, some enhancements have been proposed to the Bluetooth Specification Interest Group (SIG which is the regulatory body of Bluetooth technology; nevertheless, some proposed enhancements are ineffective or are not yet implemented by Manufacturers. Therefore, an improvement of the security authentication in Bluetooth connection is highly required to overcome the existing drawbacks. This proposed protocol uses Hash-based Message Authentication Code (HMAC algorithm with Secure Hash Algorithm (SHA-256. The implementation of this proposal is based on the Arduino Integrated Development Environment (IDE as software and a Bluetooth (BT Shield connected to an Arduino Uno R3 boards as hardware. The result was verified on a Graphical User Interface (GUI built in Microsoft Visual Studio 2010 with C sharp as default environment. It has shown that the proposed scheme works perfectly with the used hardware and software. In addition, the

  12. Connectivity in the deep: Phylogeography of the velvet belly lanternshark

    Science.gov (United States)

    Gubili, Chrysoula; Macleod, Kirsty; Perry, William; Hanel, Pia; Batzakas, Ioannis; Farrell, Edward D.; Lynghammar, Arve; Mancusi, Cecilia; Mariani, Stefano; Menezes, Gui M.; Neat, Francis; Scarcella, Giuseppe; Griffiths, Andrew M.

    2016-09-01

    The velvet belly lanternshark, Etmopterus spinax, is a deep-sea bioluminescent squaloid shark, found predominantly in the Northeast Atlantic and Mediterranean Sea. It has been exposed to relatively high levels of mortality associated with by-catch in some regions. Its late maturity and low fecundity potentially renders it vulnerable to over-exploitation, although little remains known about processes of connectivity between key habitats/regions. This study utilised DNA sequencing of partial regions of the mitochondrial control region and nuclear ribosomal internal transcribed spacer 2 to investigate population structure and phylogeography of this species across the Northeast Atlantic and Mediterranean Basin. Despite the inclusion of samples from the range edges or remote locations, no evidence of significant population structure was detected. An important exception was identified using the control region sequence, with much greater (and statistically significant) levels of genetic differentiation between the Mediterranean and Atlantic. This suggests that the Strait of Gibraltar may represent an important bathymetric barrier, separating regions with very low levels of female dispersal. Bayesian estimation of divergence time also places the separation between the Mediterranean and Atlantic lineages within the last 100,000 years, presumably connected with perturbations during the last Glacial Period. These results demonstrate population subdivision at a much smaller geographic distance than has generally been identified in previous work on deep-sea sharks. This highlights a very significant role for shallow bathymetry in promoting genetic differentiation in deepwater taxa. It acts as an important exception to a general paradigm of marine species being connected by high levels of gene-flow, representing single stocks over large scales. It may also have significant implications for the fisheries management of this species.

  13. Solid phase sequencing of biopolymers

    Energy Technology Data Exchange (ETDEWEB)

    Cantor, Charles R.; Hubert, Koster

    2014-06-24

    This invention relates to methods for detecting and sequencing target nucleic acid sequences, to mass modified nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involve hybridizing the nucleic acids or nucleic acids which represent complementary or homologous sequences of the target to an array of nucleic acid probes. These probes comprise a single-stranded portion, an optional double-stranded portion and a variable sequence within the single-stranded portion. The molecular weights of the hybridized nucleic acids of the set can be determined by mass spectroscopy, and the sequence of the target determined from the molecular weights of the fragments. Probes may be affixed to a solid support such as a hybridization chip to facilitate automated molecular weight analysis and identification of the target sequence.

  14. Turtle Graphics of Morphic Sequences

    Science.gov (United States)

    Zantema, Hans

    2016-02-01

    The simplest infinite sequences that are not ultimately periodic are pure morphic sequences: fixed points of particular morphisms mapping single symbols to strings of symbols. A basic way to visualize a sequence is by a turtle curve: for every alphabet symbol fix an angle, and then consecutively for all sequence elements draw a unit segment and turn the drawing direction by the corresponding angle. This paper investigates turtle curves of pure morphic sequences. In particular, criteria are given for turtle curves being finite (consisting of finitely many segments), and for being fractal or self-similar: it contains an up-scaled copy of itself. Also space-filling turtle curves are considered, and a turtle curve that is dense in the plane. As a particular result we give an exact relationship between the Koch curve and a turtle curve for the Thue-Morse sequence, where until now for such a result only approximations were known.

  15. Graphene nanodevices for DNA sequencing

    Science.gov (United States)

    Heerema, Stephanie J.; Dekker, Cees

    2016-02-01

    Fast, cheap, and reliable DNA sequencing could be one of the most disruptive innovations of this decade, as it will pave the way for personalized medicine. In pursuit of such technology, a variety of nanotechnology-based approaches have been explored and established, including sequencing with nanopores. Owing to its unique structure and properties, graphene provides interesting opportunities for the development of a new sequencing technology. In recent years, a wide range of creative ideas for graphene sequencers have been theoretically proposed and the first experimental demonstrations have begun to appear. Here, we review the different approaches to using graphene nanodevices for DNA sequencing, which involve DNA passing through graphene nanopores, nanogaps, and nanoribbons, and the physisorption of DNA on graphene nanostructures. We discuss the advantages and problems of each of these key techniques, and provide a perspective on the use of graphene in future DNA sequencing technology.

  16. Short sequence motifs, overrepresented in mammalian conservednon-coding sequences

    Energy Technology Data Exchange (ETDEWEB)

    Minovitsky, Simon; Stegmaier, Philip; Kel, Alexander; Kondrashov,Alexey S.; Dubchak, Inna

    2007-02-21

    Background: A substantial fraction of non-coding DNAsequences of multicellular eukaryotes is under selective constraint. Inparticular, ~;5 percent of the human genome consists of conservednon-coding sequences (CNSs). CNSs differ from other genomic sequences intheir nucleotide composition and must play important functional roles,which mostly remain obscure.Results: We investigated relative abundancesof short sequence motifs in all human CNSs present in the human/mousewhole-genome alignments vs. three background sets of sequences: (i)weakly conserved or unconserved non-coding sequences (non-CNSs); (ii)near-promoter sequences (located between nucleotides -500 and -1500,relative to a start of transcription); and (iii) random sequences withthe same nucleotide composition as that of CNSs. When compared tonon-CNSs and near-promoter sequences, CNSs possess an excess of AT-richmotifs, often containing runs of identical nucleotides. In contrast, whencompared to random sequences, CNSs contain an excess of GC-rich motifswhich, however, lack CpG dinucleotides. Thus, abundance of short sequencemotifs in human CNSs, taken as a whole, is mostly determined by theiroverall compositional properties and not by overrepresentation of anyspecific short motifs. These properties are: (i) high AT-content of CNSs,(ii) a tendency, probably due to context-dependent mutation, of A's andT's to clump, (iii) presence of short GC-rich regions, and (iv) avoidanceof CpG contexts, due to their hypermutability. Only a small number ofshort motifs, overrepresented in all human CNSs are similar to bindingsites of transcription factors from the FOX family.Conclusion: Human CNSsas a whole appear to be too broad a class of sequences to possess strongfootprints of any short sequence-specific functions. Such footprintsshould be studied at the level of functional subclasses of CNSs, such asthose which flank genes with a particular pattern of expression. Overallproperties of CNSs are affected by

  17. Nonlinear analysis of biological sequences

    Energy Technology Data Exchange (ETDEWEB)

    Torney, D.C.; Bruno, W.; Detours, V. [and others

    1998-11-01

    This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The main objectives of this project involved deriving new capabilities for analyzing biological sequences. The authors focused on tabulating the statistical properties exhibited by Human coding DNA sequences and on techniques of inferring the phylogenetic relationships among protein sequences related by descent.

  18. Unity connecting module in SSPF

    Science.gov (United States)

    1998-01-01

    In the Space Station Processing Facility, the Unity connecting module, part of the International Space Station, is shown with Pressurized Mating Adapters 1 (left) and 2 (right) attached. Unity is scheduled to undergo testing of the common berthing mechanism to which other space station elements will dock. Unity is the primary payload on mission STS-88, targeted to launch Dec. 3, 1998. Other testing includes the Pad Demonstration Test to verify the compatibility of the module with the Space Shuttle as well as the ability of the astronauts to send and receive commands to Unity from the flight deck of the orbiter. Unity is expected to be ready for installation into the payload canister on Oct. 25, and transported to Launch Pad 39-A on Oct. 27. The Unity will be mated to the Russian-built Zarya control module which should already be in orbit at that time.

  19. Galaxy Morphology - Halo Gas Connections

    CERN Document Server

    Kacprzak, G G; Steidel, C C; Kacprzak, Glenn G.; Churchill, Christopher W.; Steidel, Charles C.

    2005-01-01

    We studied a sample of 38 intermediate redshift MgII absorption-selected galaxies using (1) Keck/HIRES and VLT/UVES quasar spectra to measure the halo gas kinematics from MgII absorption profiles and (2) HST/WFPC-2 images to study the absorbing galaxy morphologies. We have searched for correlations between quantified gas absorption properties, and host galaxy impact parameters, inclinations, position angles, and quantified morphological parameters. We report a 3.2-sigma correlation between asymmetric perturbations in the host galaxy morphology and the MgII absorption equivalent width. We suggest that this correlation may indicate a connection between past merging and/or interaction events in MgII absorption-selected galaxies and the velocity dispersion and quantity of gas surrounding these galaxies.

  20. Method for hermetic electrical connections

    Science.gov (United States)

    Monroe, Saundra L.; Glass, S. Jill; Stone, Ronnie G.; Bond, Jamey T.; Susan, Donald F.

    2011-12-27

    A method of providing a hermetic, electrical connection between two electrical components by mating at least one metal pin in a glass-ceramic to metal seal connector to two electrical components, wherein the glass-ceramic to metal seal connector incorporates at least one metal pin encased (sealed) in a glass-ceramic material inside of a metal housing, with the glass-ceramic material made from 65-80% SiO.sub.2, 8-16% Li.sub.2O, 2-8% Al.sub.2O.sub.3, 1-5% P.sub.2O.sub.5, 1-8% K.sub.2O, 0.5-7% B.sub.2O.sub.3, and 0-5% ZnO. The connector retains hermeticity at temperatures as high as 700.degree. C. and pressures as high as 500 psi.

  1. Proliferating Connections and Communicating Convergence

    Directory of Open Access Journals (Sweden)

    Aylish Wood

    2008-01-01

    Full Text Available In this paper I use the work of Niklas Luhmann to explore what pressure the concept of convergence exerts over how we communicate about the changing expressive practices of digital games following the emergence of digital technologies. My claim will be that in its current form, convergence privileges either the human users of technological platforms, or the combination of aesthetic conventions from different media what connects is either the user or the aesthetic code. While neither of these two positions would be likely to deny a reliance on the interplay between humans and technologies, such an interplay is taken for granted rather than explored. By using Luhmann’s version of systems theory, I argue that we can more effectively grasp the interplay of human and technological participants by understanding their combined roles in changing expressive practices.

  2. Structural Connectivity of the Developing Human Amygdala

    Science.gov (United States)

    Saygin, Zeynep M.; Osher, David E.; Koldewyn, Kami; Martin, Rebecca E.; Finn, Amy; Saxe, Rebecca; Gabrieli, John D.E.; Sheridan, Margaret

    2015-01-01

    A large corpus of research suggests that there are changes in the manner and degree to which the amygdala supports cognitive and emotional function across development. One possible basis for these developmental differences could be the maturation of amygdalar connections with the rest of the brain. Recent functional connectivity studies support this conclusion, but the structural connectivity of the developing amygdala and its different nuclei remains largely unstudied. We examined age related changes in the DWI connectivity fingerprints of the amygdala to the rest of the brain in 166 individuals of ages 5-30. We also developed a model to predict age based on individual-subject amygdala connectivity, and identified the connections that were most predictive of age. Finally, we segmented the amygdala into its four main nucleus groups, and examined the developmental changes in connectivity for each nucleus. We observed that with age, amygdalar connectivity becomes increasingly sparse and localized. Age related changes were largely localized to the subregions of the amygdala that are implicated in social inference and contextual memory (the basal and lateral nuclei). The central nucleus’ connectivity also showed differences with age but these differences affected fewer target regions than the basal and lateral nuclei. The medial nucleus did not exhibit any age related changes. These findings demonstrate increasing specificity in the connectivity patterns of amygdalar nuclei across age. PMID:25875758

  3. Structural connectivity of the developing human amygdala.

    Directory of Open Access Journals (Sweden)

    Zeynep M Saygin

    Full Text Available A large corpus of research suggests that there are changes in the manner and degree to which the amygdala supports cognitive and emotional function across development. One possible basis for these developmental differences could be the maturation of amygdalar connections with the rest of the brain. Recent functional connectivity studies support this conclusion, but the structural connectivity of the developing amygdala and its different nuclei remains largely unstudied. We examined age related changes in the DWI connectivity fingerprints of the amygdala to the rest of the brain in 166 individuals of ages 5-30. We also developed a model to predict age based on individual-subject amygdala connectivity, and identified the connections that were most predictive of age. Finally, we segmented the amygdala into its four main nucleus groups, and examined the developmental changes in connectivity for each nucleus. We observed that with age, amygdalar connectivity becomes increasingly sparse and localized. Age related changes were largely localized to the subregions of the amygdala that are implicated in social inference and contextual memory (the basal and lateral nuclei. The central nucleus' connectivity also showed differences with age but these differences affected fewer target regions than the basal and lateral nuclei. The medial nucleus did not exhibit any age related changes. These findings demonstrate increasing specificity in the connectivity patterns of amygdalar nuclei across age.

  4. Structural connectivity of the developing human amygdala.

    Science.gov (United States)

    Saygin, Zeynep M; Osher, David E; Koldewyn, Kami; Martin, Rebecca E; Finn, Amy; Saxe, Rebecca; Gabrieli, John D E; Sheridan, Margaret

    2015-01-01

    A large corpus of research suggests that there are changes in the manner and degree to which the amygdala supports cognitive and emotional function across development. One possible basis for these developmental differences could be the maturation of amygdalar connections with the rest of the brain. Recent functional connectivity studies support this conclusion, but the structural connectivity of the developing amygdala and its different nuclei remains largely unstudied. We examined age related changes in the DWI connectivity fingerprints of the amygdala to the rest of the brain in 166 individuals of ages 5-30. We also developed a model to predict age based on individual-subject amygdala connectivity, and identified the connections that were most predictive of age. Finally, we segmented the amygdala into its four main nucleus groups, and examined the developmental changes in connectivity for each nucleus. We observed that with age, amygdalar connectivity becomes increasingly sparse and localized. Age related changes were largely localized to the subregions of the amygdala that are implicated in social inference and contextual memory (the basal and lateral nuclei). The central nucleus' connectivity also showed differences with age but these differences affected fewer target regions than the basal and lateral nuclei. The medial nucleus did not exhibit any age related changes. These findings demonstrate increasing specificity in the connectivity patterns of amygdalar nuclei across age. PMID:25875758

  5. Local Natural Connectivity in Complex Networks

    Institute of Scientific and Technical Information of China (English)

    SHANG Yi-Lun

    2011-01-01

    @@ In network theory, a complex network represents a system whose evolving structure and dynamic behavior contribute to its robustness.The natural connectivity is recently proposed as a spectral measure to characterize the robustness of complex networks.We decompose the natural connectivity of a network as local natural connectivity of its connected components and quantify their contributions to the network robustness.In addition, we compare the natural connectivity of a network with that of an induced subgraph of it based on interlacing theorems.As an application, we derive an inequality for eigenvalues of ErdSs-Renyi random graphs.%In network theory, a complex network represents a system whose evolving structure and dynamic behavior contribute to its robustness. The natural connectivity is recently proposed as a spectral measure to characterize the robustness of complex networks. We decompose the natural connectivity of a network as local naturai connectivity of its connected components and quantify their contributions to the network robustness. In addition, we compare the naturai connectivity of a network with that of an induced subgraph of it based on interlacing theorems. As an application, we derive an inequality for eigenvalues of Erdos-Renyi random graphs.

  6. [Connective tissue and prolapse genesis].

    Science.gov (United States)

    Tremollieres, F

    2010-06-01

    The pathophysiology of pelvic floor disorders still remains not well understood. Increasing age as well as vaginal multiparity are the main commonly accepted factors. The hypothesis of a defect of connective tissues of the pelvic floor with aging due to collagen deficiency and/or elastic fiber degradation is often highlighted. The issue of a potential protective role of HRT is also discussed although the recent results from the WHI would suggest a negative impact of HRT on urinary incontinence, especially when HRT is initiated in elderly women, far from the menopause. Nevertheless, environmental factors cannot explain the full pathogenesis of pelvic organ prolapse (POP) and the contribution of genetic factors to the development of pelvic floor disorders is widely recognized. Support for a genetic influence on POP derives from reports suggesting that heritability is a strong contributing factor and a familial history of POP is considered as a classical risk factor. However, the characterization of the underlying molecular mechanisms remains limited, since POP may be considered the end result of a multifactorial process leading to destruction of vaginal wall connective tissue. Experimental studies in mice with null mutations in the genes encoding different putative factors involved in elastic fibers remodeling and homeostasis are crucial in the understanding of the pathogenesis of POP. Mice with null mutation in the gene encoding lysyl oxidase-like 1 (LOXL1) or fibulin-5, demonstrate signs of elastinopathy including the development of a POP in the postpartum. Likewise, homeobox genes such as HOXA11, which are essential in the embryonic development of the urogenital tract might also be involved in the pathogenesis of POP. The better understanding of the underlying determinants of pelvic floor disorders with a special focus on genetic factors may offer new therapeutic strategies, in addition to or replacement of surgical procedures.

  7. Boundary effects in welded steel moment connections

    Science.gov (United States)

    Lee, Kyoung-Hyeog

    Unprecedented widespread failure of welded moment connections in steel frames caused by the 1994 Northridge and the 1995 Kobe earthquakes have alarmed the engineering communities throughout the world. Welded moment connections in steel frames have been traditionally designed by using the classical beam theory which leads to assumptions that the flanges transfer moment while the web connection primarily resists the shear force. However, this study shows that the magnitude and direction of the principal stresses in the connection region are better approximated by using truss analogy rather than the classical beam theory. Accordingly, both the bending moment and the shear force are transferred across the connection near the beam flanges through diagonal strut action. Thus, the beam flange region of the traditionally designed connection is overloaded. This conclusion explains, to a large extent, the recently observed steel moment connection failures. In this study, detailed finite element analyses were carried out for a representative beam-to-column subassemblage with fully welded connection. The stress distribution in the beam web and flanges in the vicinity of the connection were closely studied. The factors responsible for stress redistribution and concentration were identified by using fundamental principles of mechanics. It was concluded that peak resultant stresses can exceed the values used in simple design calculations by large margins. Using the finite element analysis results and the truss analogy to establish a realistic load path in the connection, a practical and more rational analysis and design procedure was developed. The proposed design procedure and the new connection details were successfully validated through cyclic load testing of a nearly full size specimen. The truss model represented the force transmission around the beam-to-column moment connection region very well. Results of the finite element analyses and the laboratory testing showed

  8. Blazar Sequence in Fermi Era

    Indian Academy of Sciences (India)

    Liang Chen

    2014-09-01

    In this paper, we review the latest research results on the topic of blazar sequence. It seems that the blazar sequence is phenomenally ruled out, while the theoretical blazar sequence still holds. We point out that black hole mass is a dominated parameter accounting for high-power-high-synchrotron-peaked and low-power-low-sychrotron-peaked blazars. Because most blazars have similar size of emission region, theoretical blazar sequence implies that the break of Spectral Energy Distribution (SED) is a cooling break in nature.

  9. SNMR pulse sequence phase cycling

    Science.gov (United States)

    Walsh, David O; Grunewald, Elliot D

    2013-11-12

    Technologies applicable to SNMR pulse sequence phase cycling are disclosed, including SNMR acquisition apparatus and methods, SNMR processing apparatus and methods, and combinations thereof. SNMR acquisition may include transmitting two or more SNMR pulse sequences and applying a phase shift to a pulse in at least one of the pulse sequences, according to any of a variety cycling techniques. SNMR processing may include combining SNMR from a plurality of pulse sequences comprising pulses of different phases, so that desired signals are preserved and indesired signals are canceled.

  10. Assembly sequencing with toleranced parts

    Energy Technology Data Exchange (ETDEWEB)

    Latombe, J.C. [Stanford Univ., CA (United States). Robotics Lab.; Wilson, R.H. [Sandia National Labs., Albuquerque, NM (United States). Intelligent Systems and Robotics Center

    1995-02-21

    The goal of assembly sequencing is to plan a feasible series of operations to construct a product from its individual parts. Previous research has thoroughly investigated assembly sequencing under the assumption that parts have nominal geometry. This paper considers the case where parts have toleranced geometry. Its main contribution is an efficient procedure that decides if a product admits an assembly sequence with infinite translations that is feasible for all possible instances of the components within the specified tolerances. If the product admits one such sequence, the procedure can also generate it. For the cases where there exists no such assembly sequence, another procedure is proposed which generates assembly sequences that are feasible only for some values of the toleranced dimensions. If this procedure produces no such sequence, then no instance of the product is assemblable. Finally, this paper analyzes the relation between assembly and disassembly sequences in the presence of toleranced parts. This work assumes a simple, but non-trivial tolerance language that falls short of capturing all imperfections of a manufacturing process. Hence, it is only one step toward assembly sequencing with toleranced parts.

  11. The ontology of biological sequences

    Directory of Open Access Journals (Sweden)

    Kelso Janet

    2009-11-01

    Full Text Available Abstract Background Biological sequences play a major role in molecular and computational biology. They are studied as information-bearing entities that make up DNA, RNA or proteins. The Sequence Ontology, which is part of the OBO Foundry, contains descriptions and definitions of sequences and their properties. Yet the most basic question about sequences remains unanswered: what kind of entity is a biological sequence? An answer to this question benefits formal ontologies that use the notion of biological sequences and analyses in computational biology alike. Results We provide both an ontological analysis of biological sequences and a formal representation that can be used in knowledge-based applications and other ontologies. We distinguish three distinct kinds of entities that can be referred to as "biological sequence": chains of molecules, syntactic representations such as those in biological databases, and the abstract information-bearing entities. For use in knowledge-based applications and inclusion in biomedical ontologies, we implemented the developed axiom system for use in automated theorem proving. Conclusion Axioms are necessary to achieve the main goal of ontologies: to formally specify the meaning of terms used within a domain. The axiom system for the ontology of biological sequences is the first elaborate axiom system for an OBO Foundry ontology and can serve as starting point for the development of more formal ontologies and ultimately of knowledge-based applications.

  12. ABS: Sequence alignment by scanning

    KAUST Repository

    Bonny, Mohamed Talal

    2011-08-01

    Sequence alignment is an essential tool in almost any computational biology research. It processes large database sequences and considered to be high consumers of computation time. Heuristic algorithms are used to get approximate but fast results. We introduce fast alignment algorithm, called Alignment By Scanning (ABS), to provide an approximate alignment of two DNA sequences. We compare our algorithm with the well-known alignment algorithms, the FASTA (which is heuristic) and the \\'Needleman-Wunsch\\' (which is optimal). The proposed algorithm achieves up to 76% enhancement in alignment score when it is compared with the FASTA Algorithm. The evaluations are conducted using different lengths of DNA sequences. © 2011 IEEE.

  13. Fast global sequence alignment technique

    KAUST Repository

    Bonny, Mohamed Talal

    2011-11-01

    Bioinformatics database is growing exponentially in size. Processing these large amount of data may take hours of time even if super computers are used. One of the most important processing tool in Bioinformatics is sequence alignment. We introduce fast alignment algorithm, called \\'Alignment By Scanning\\' (ABS), to provide an approximate alignment of two DNA sequences. We compare our algorithm with the wellknown sequence alignment algorithms, the \\'GAP\\' (which is heuristic) and the \\'Needleman-Wunsch\\' (which is optimal). The proposed algorithm achieves up to 51% enhancement in alignment score when it is compared with the GAP Algorithm. The evaluations are conducted using different lengths of DNA sequences. © 2011 IEEE.

  14. Multilocus Sequence Typing of Total-Genome-Sequenced Bacteria

    DEFF Research Database (Denmark)

    Larsen, Mette Voldby; Cosentino, Salvatore; Rasmussen, Simon;

    2012-01-01

    Accurate strain identification is essential for anyone working with bacteria. For many species, multilocus sequence typing (MLST) is considered the "gold standard" of typing, but it is traditionally performed in an expensive and time-consuming manner. As the costs of whole-genome sequencing (WGS)...

  15. Evaluation of a rapid, multi-phase MRE sequence in a heart-simulating phantom

    OpenAIRE

    Kolipaka, Arunark; McGee, Kiaran P.; Araoz, Philip A; Glaser, Kevin J.; Manduca, Armando; Ehman, Richard L.

    2009-01-01

    The aims of this study were to validate stiffness estimates of a phantom undergoing cyclic deformation obtained using a multi-phase magnetic resonance elastography (MRE) imaging sequence by comparison with those obtained using a single-phase MRE sequence and to quantify the stability of the multi-phase-derived stiffness estimates as a function of deformation frequency and imaging parameters. A spherical rubber-shell of 10 cm diameter and 1 cm thickness was connected to a computerized flow pum...

  16. Natural environments, nature relatedness and the ecological theater: connecting satellites and sequencing to shinrin-yoku.

    Science.gov (United States)

    Craig, Jeffrey M; Logan, Alan C; Prescott, Susan L

    2016-01-13

    Recent advances in research concerning the public health value of natural environments have been remarkable. The growing interest in this topic (often housed under terms such as green and/or blue space) has been occurring in parallel with the microbiome revolution and an increased use of remote sensing technology in public health. In the context of biodiversity loss, rapid urbanization, and alarming rates of global non-communicable diseases (many associated with chronic, low-grade inflammation), discussions of natural vis-a-vis built environments are not merely fodder for intellectual curiosity. Here, we argue for increased interdisciplinary collaboration with the aim of better understanding the mechanisms-including aerobiological and epigenetic-that might help explain some of the noted positive health outcomes. It is our contention that some of these mechanisms are related to ecodiversity (i.e., the sum of biodiversity and geodiversity, including biotic and abiotic constituents). We also encourage researchers to more closely examine individual nature relatedness and how it might influence many outcomes that are at the interface of lifestyle habits and contact with ecodiversity.

  17. Natural environments, nature relatedness and the ecological theater: connecting satellites and sequencing to shinrin-yoku.

    Science.gov (United States)

    Craig, Jeffrey M; Logan, Alan C; Prescott, Susan L

    2016-01-01

    Recent advances in research concerning the public health value of natural environments have been remarkable. The growing interest in this topic (often housed under terms such as green and/or blue space) has been occurring in parallel with the microbiome revolution and an increased use of remote sensing technology in public health. In the context of biodiversity loss, rapid urbanization, and alarming rates of global non-communicable diseases (many associated with chronic, low-grade inflammation), discussions of natural vis-a-vis built environments are not merely fodder for intellectual curiosity. Here, we argue for increased interdisciplinary collaboration with the aim of better understanding the mechanisms-including aerobiological and epigenetic-that might help explain some of the noted positive health outcomes. It is our contention that some of these mechanisms are related to ecodiversity (i.e., the sum of biodiversity and geodiversity, including biotic and abiotic constituents). We also encourage researchers to more closely examine individual nature relatedness and how it might influence many outcomes that are at the interface of lifestyle habits and contact with ecodiversity. PMID:26763049

  18. Formal Connections for families of Star Products

    DEFF Research Database (Denmark)

    Ellegaard Andersen, Jørgen; Masulli, Paolo; Schaetz, Florian

    We define the notion of a formal connection for a smooth family of star products with fixed underlying symplectic structure. Such a formal connection allows one to relate star products at different points in the family. This generalizes the formal Hitchin connection introduced by the first author....... We establish a necessary and sufficient condition that guarantees the existence of a formal connection, and we describe the space of formal connections for a family as an affine space modelled by the derivations of the star products. Moreover we show that if the parameter space has trivial first...... cohomology group any two flat formal connections are related by an automorphism of the family of star products....

  19. Connectivity analysis of controlled quantum systems

    Science.gov (United States)

    Wu, Rong; Rabitz, Herschel; Turinici, Gabriel; Sola, Ignacio

    2004-11-01

    A connectivity analysis of controlled quantum systems assesses the feasibility of a field existing that can transfer at least some amplitude between any specified pair of states. Although Hamiltonians with special structure or symmetry may not produce full connectivity, it is argued and demonstrated that virtually any Hamiltonian is expected to be connected. The connectivity of any particular system is generally revealed in the quantum evolution over a single or at most a few time steps. A connectivity analysis is inexpensive to perform and it can also identify statistically significant intermediate states linking a specified initial and final state. These points are illustrated with several simple systems. The likelihood of an arbitrary system being connected implies that at least some product yield can be expected in the laboratory for virtually all systems subjected to a suitable control.

  20. TE-dependent spatial and spectral specificity of functional connectivity.

    Science.gov (United States)

    Wu, Changwei W; Gu, Hong; Zou, Qihong; Lu, Hanbing; Stein, Elliot A; Yang, Yihong

    2012-02-15

    Previous studies suggest that spontaneous fluctuations in the resting-state fMRI (RS-fMRI) signal may reflect fluctuations in transverse relaxation time (T(2)(*)) rather than spin density (S(0)). However, such S(0) and T(2)(*) features have not been well characterized. In this study, spatial and spectral characteristics of functional connectivity on sensorimotor, default-mode, dorsal attention, and primary visual systems were examined using a multiple gradient-echo sequence at 3T. In the spatial domain, we found broad, local correlations at short echo times (TE ≤ 14 ms) due to dominant S(0) contribution, whereas long-range connections mediated by T(2)(*) became explicit at TEs longer than 22 ms. In the frequency domain, compared with the flat spectrum of S(0), spectral power of the T(2)(*)-weighted signal elevated significantly with increasing TE, particularly in the frequency ranges of 0.008-0.023 Hz and 0.037-0.043 Hz. Using the S(0) spectrum as a reference, we propose two indices to measure spectral signal change (SSC) and spectral contrast-to-noise ratio (SCNR), respectively, for quantifying the RS-fMRI signal. These indices demonstrated TE dependency of connectivity-related fluctuation strength, resembling functional contrasts in activation-based fMRI. These findings further confirm that large-scale functional circuit connectivity based on BOLD contrast may be constrained within specific frequency ranges in every brain network, and the spectral features of S(0) and T(2)(*) could be valuable for interpreting and quantifying RS-fMRI data. PMID:22119650

  1. A Multidata Connection Scheme for Big Data High-Dimension Using the Data Connection Coefficient

    Directory of Open Access Journals (Sweden)

    Yoon-su Jeong

    2015-01-01

    Full Text Available In the era of big data and cloud computing, sources and types of data vary, and the volume and flow of data are massive and continuous. With the widespread use of mobile devices and the Internet, huge volumes of data distributed over heterogeneous networks move forward and backward across networks. In order to meet the demands of big data service providers and customers, efficient technologies for processing and transferring big data over networks are needed. This paper proposes a multidata connection (MDC scheme that decreases the amount of power and time necessary for information to be communicated between the content server and the mobile users (i.e., the content consumers who are moving freely across different networks while using their mobile devices. MDC scheme is an approach to data validation that requires the presentation of two or more pieces of data in a heterogeneous environment of big data. The MDC transmits the difference of the consecutive data sequences instead of sending the data itself to the receiver, thus increasing transmission throughput and speed.

  2. Modeling of preloaded threaded pipe connections

    OpenAIRE

    Van Wittenberghe, Jeroen; DE BAETS, Patrick; De Waele, Wim

    2009-01-01

    In this paper a modeling method to perform parametric studies on preloaded threaded connections is presented. The method uses a non-linear 2D axisymmetric finite element model, and is illustrated by a parametric study of an API Line Pipe connection. The method was used to quantify the influence of the coefficient of friction, the wall thickness of pin and box and the box recess length of the connection.

  3. Review on Cold-Formed Steel Connections

    OpenAIRE

    Yeong Huei Lee; Cher Siang Tan; Shahrin Mohammad; Mahmood Md. Tahir; Poi Ngian Shek

    2014-01-01

    The concept of cold-formed light steel framing construction has been widespread after understanding its structural characteristics with massive research works over the years. Connection serves as one of the important elements for light steel framing in order to achieve its structural stability. Compared to hot-rolled steel sections, cold-formed steel connections perform dissimilarity due to the thin-walled behaviour. This paper aims to review current researches on cold-formed steel connection...

  4. Connected Car: Quantified Self becomes Quantified Car

    OpenAIRE

    Melanie Swan

    2015-01-01

    The automotive industry could be facing a situation of profound change and opportunity in the coming decades. There are a number of influencing factors such as increasing urban and aging populations, self-driving cars, 3D parts printing, energy innovation, and new models of transportation service delivery (Zipcar, Uber). The connected car means that vehicles are now part of the connected world, continuously Internet-connected, generating and transmitting data, which on the one hand can be hel...

  5. A Connection between Gravitation and Electromagnetism

    OpenAIRE

    Snyder, D. M.

    2000-01-01

    It is argued that there is a connection between the fundamental forces of electromagnetism and gravitation. This connection occurs because of: 1) the fundamental significance of the finite and invariant velocity of light in inertial reference frames in the special theory, and 2) the reliance of the general theory of relativity upon the special theory of relativity locally in spacetime. The connection between the fundamental forces of electromagnetism and gravitation follows immediately from t...

  6. Conformal transformation of tetrads and spin connection

    CERN Document Server

    Chakrabarty, Subhasish

    2016-01-01

    We investigate the conformal transformation of vierbein-Einstein-Palatini (VEP) action in terms of tetrads $e^I_\\mu$ and spin connection $A^{IJ}_\\mu$. The transformation of tetrads is obtained from that of the spacetime metric whereas that of the spin connection is not unique off-shell. When the connection can be completely expressed in terms of the tetrads, its transformation follows from that of the tetrads. We also construct the conformally invariant scalar field in the VEP formalism.

  7. Notes on sentential connections (predominantly) in Portuguese

    OpenAIRE

    Peres, João Andrade; Mascarenhas, Salvador

    2005-01-01

    In this article, we discuss a general typology of inter-sentential connections involving an explicit connective, including but no limited to subordination and coordination. In the first section, we briefly describe a proposal on the topic by one of the authors, which is taken as a point of departure. In the following section, we analyse step by step the diverse levels of organization of the connection system, ending in an overall picture and a suggestion of further additions related to hither...

  8. Conley: Computing connection matrices in Maple

    OpenAIRE

    Barakat, Mohamed; Robertz, Daniel

    2007-01-01

    In this work we announce the Maple package conley to compute connection and C-connection matrices. conley is based on our abstract homological algebra package homalg. We emphasize that the notion of braids is irrelevant for the definition and for the computation of such matrices. We introduce the notion of triangles that suffices to state the definition of (C)-connection matrices. The notion of octahedra, which is equivalent to that of braids is also introduced.

  9. Bluetooth LE (Low Energy) Connection Management

    OpenAIRE

    Khan, Olid Hossain

    2015-01-01

    This Bachelor’s thesis describes an Android Bluetooth Low Energy connection management collects sensor measurement data frequently and continuously from Bluetooth Low Energy devices to an Android phone. Currently there exists no such application that can connect with Bluetooth Low Energy devices continuously in a very short interval of time. Existing applications are also facing problems to establish a Bluetooth connection with Bluetooth Low Energy devices smoothly. The target of this res...

  10. The neural correlates of social connection

    OpenAIRE

    Hutcherson, Cendri A.; Seppala, Emma M.; James J Gross

    2015-01-01

    Cultivating social connection has long been a goal of psychology, philosophy, religion, and public policy. Yet the psychological and neural responses that accompany a feeling of connection to others remain unclear. In the present study, we used functional neuroimaging to shed light on the neural correlates of self- and other-focused processes during the successful self-generation of feelings of social connection. To do this, we used a trait judgment task to localize functional activation rela...

  11. Augmented brain function by coordinated reset stimulation with slowly varying sequences

    Directory of Open Access Journals (Sweden)

    Magteld eZeitler

    2015-03-01

    Full Text Available Several brain disorders are characterized by abnormally strong neuronal synchrony. Coordinated Reset (CR stimulation was developed to selectively counteract abnormal neuronal synchrony by desynchronization. For this, phase resetting stimuli are delivered to different subpopulations in a timely coordinated way. In neural networks with spike timing-dependent plasticity CR stimulation may eventually lead to an anti-kindling, i.e. an unlearning of abnormal synaptic connectivity and abnormal synchrony. The spatiotemporal sequence by which all stimulation sites are stimulated exactly once is called the stimulation site sequence, or briefly sequence. So far, in simulations, pre-clinical and clinical applications CR was applied either with fixed sequences or rapidly varying sequences (RVS. In this computational study we show that appropriate repetition of the sequence with occasional random switching to the next sequence may significantly improve the anti-kindling effect of CR. To this end, a sequence is applied many times before randomly switching to the next sequence. This new method is called SVS CR stimulation, i.e. CR with slowly varying sequences. In a neuronal network with strong short-range excitatory and weak long-range inhibitory dynamic couplings SVS CR stimulation turns out to be superior to CR stimulation with fixed sequences or RVS.

  12. Drill pipe threaded nipple connection design development

    Science.gov (United States)

    Saruev, A. L.; Saruev, L. A.; Vasenin, S. S.

    2015-11-01

    The paper presents the analysis of the behavior of the drill pipe nipple connection under the additional load generated by power pulses. The strain wave propagation through the nipple thread connection of drill pipes to the bottomhole is studied in this paper. The improved design of the nipple thread connection is suggested using the obtained experimental and theoretical data. The suggested connection design allows not only the efficient transmission of strain wave energy to a drill bit but also the automation of making-up and breaking-out drill pipes.

  13. On Metrizability of Invariant Affine Connections

    CERN Document Server

    Tanaka, Erico

    2011-01-01

    The metrizability problem for a symmetric affine connection on a manifold, invariant with respect to a group of diffeomorphisms G, is considered. We say that the connection is G-metrizable, if it is expressible as the Levi-Civita connection of a G-invariant metric field. In this paper we analyze the G-metrizability equations for the rotation group G = SO(3), acting canonically on three- and four-dimensional Euclidean spaces. We show that the property of the connection to be SO(3)-invariant allows us to find complete explicit description of all solutions of the SO(3)-metrizability equations.

  14. Affine connections, midpoint formation, and point reflection

    DEFF Research Database (Denmark)

    Kock, Anders

    2011-01-01

    We describe some differential-geometric structures in combinatorial terms: namely affine connections and their torsion and curvature, and we show that torsion free affine connections may equivalently be presented in terms of some simpler combinatorial structure: midpoint formation, and point refl...... reflection (geodesic symmetry). The method employed is that of synthetic differential geometry, which is briefly explained.......We describe some differential-geometric structures in combinatorial terms: namely affine connections and their torsion and curvature, and we show that torsion free affine connections may equivalently be presented in terms of some simpler combinatorial structure: midpoint formation, and point...

  15. Essential Connectivity Areas - CEHC, (Raster) [ds620

    Data.gov (United States)

    California Department of Resources — The California Department of Transportation (Caltrans) and California Department of Fish and Game (CDFG) commissioned the California Essential Habitat Connectivity...

  16. Neighborhood connected perfect domination in graphs

    Directory of Open Access Journals (Sweden)

    Kulandai Vel M.P.

    2012-12-01

    Full Text Available Let $G = (V, E$ be a connected graph. A set $S$ of vertices in $G$ is a perfect dominating set if every vertex $v$ in $V-S$ is adjacent to exactly one vertex in $S$. A perfect dominating set $S$ is said to be a neighborhood connected perfect dominating set (ncpd-set if the induced subgraph $$ is connected. The minimum cardinality of a ncpd-set of $G$ is called the neighborhood connected perfect domination number of $G$ and is denoted by $\\gamma_{ncp}(G$. In this paper we initiate a study of this parameter.

  17. Connection Skeleton Extraction Based on Contour Connectedness

    Institute of Scientific and Technical Information of China (English)

    CHEN Mang; LIU Yun-cai

    2008-01-01

    A stable skeleton is very important to some applications such as vehicle navigation, object represent and pattern recognition. The connection skeleton is just one that not only can be computed stably but also can figure the connectivity structure of contour. A new method named continuous connectivity detection and a new model named approximate regular polygon (ARP) were proposed for connection skeleton extraction. Both the method and the model were tested by the real maps of road network including flyovers, interchanges and other common object contours. Satisfactory results were obtained.

  18. Further advances in deepwater flowline connection technology

    Energy Technology Data Exchange (ETDEWEB)

    Moreira, J.R.; Cerqueira, M.B.; Silva, G.J.R.; Nagle, R.J.

    1996-12-31

    A diverless guidelineless flowline connection system, the so-called direct vertical connection, has been developed, and tested, which sharply decreases connection time, while allowing the lay-vessel itself to perform both flowline ends connections, thus dispensing with the use of auxiliary tools and making the operation more cost effective and reliable. This system has been designed to overcome problems associated with conventional pull-in systems, the lay-away method, ROV assisted pull-in systems and conventional vertical connections. The former have already been successfully used in Marlim field, in 25 wells located at water depths ranging from 740 m to 980 m. The direct vertical connection can now be considered a field proven method. Five import flowline connections have already been successfully performed in Albacora field manifold, installed at 620 m water depth. From now on, based on the excellent results achieved from those installations and previous tests, all deepwater Brazilian subsea trees and manifolds will be designed for direct vertical connection. Sixty six trees and six manifolds incorporating the direct vertical connection system are presently under fabrication in Brazil.

  19. Finite extensions of Bessel sequences

    OpenAIRE

    Bakić, Damir; Berić, Tomislav

    2015-01-01

    The paper studies finite extensions of Bessel sequences in infinite-dimensional Hilbert spaces. We provide a characterization of Bessel sequences that can be extended to frames by adding finitely many vectors. We also characterize frames that can be converted to Parseval frames by finite-dimensional perturbations. Finally, some results on excesses of frames and near-Riesz bases are derived.

  20. Sequence conserved for subcellular localization

    Science.gov (United States)

    Nair, Rajesh; Rost, Burkhard

    2002-01-01

    The more proteins diverged in sequence, the more difficult it becomes for bioinformatics to infer similarities of protein function and structure from sequence. The precise thresholds used in automated genome annotations depend on the particular aspect of protein function transferred by homology. Here, we presented the first large-scale analysis of the relation between sequence similarity and identity in subcellular localization. Three results stood out: (1) The subcellular compartment is generally more conserved than what might have been expected given that short sequence motifs like nuclear localization signals can alter the native compartment; (2) the sequence conservation of localization is similar between different compartments; and (3) it is similar to the conservation of structure and enzymatic activity. In particular, we found the transition between the regions of conserved and nonconserved localization to be very sharp, although the thresholds for conservation were less well defined than for structure and enzymatic activity. We found that a simple measure for sequence similarity accounting for pairwise sequence identity and alignment length, the HSSP distance, distinguished accurately between protein pairs of identical and different localizations. In fact, BLAST expectation values outperformed the HSSP distance only for alignments in the subtwilight zone. We succeeded in slightly improving the accuracy of inferring localization through homology by fine tuning the thresholds. Finally, we applied our results to the entire SWISS-PROT database and five entirely sequenced eukaryotes. PMID:12441382

  1. PERIODIC COMPLEMENTARY BINARY SEQUENCE PAIRS

    Institute of Scientific and Technical Information of China (English)

    XuChengqian; ZhaoXiaoqun

    2002-01-01

    A new set of binary sequences-Periodic Complementary Binary Sequence Pair (PCSP)is proposed .A new class of block design-Difference Family Pair (DFP)is also proposed .The relationship between PCSP and DFP,the properties and exising conditions of PCSP and the recursive constructions for PCSP are given.

  2. PERIODIC COMPLEMENTARY BINARY SEQUENCE PAIRS

    Institute of Scientific and Technical Information of China (English)

    Xu Chengqian; Zhao Xiaoqun

    2002-01-01

    A new set of binary sequences-Periodic Complementary Binary Sequence Pair (PCSP) is proposed. A new class of block design-Difference Family Pair (DFP) is also proposed.The relationship between PCSP and DFP, the properties and existing conditions of PCSP and the recursive constructions for PCSP are given.

  3. Rapid Diagnostics of Onboard Sequences

    Science.gov (United States)

    Starbird, Thomas W.; Morris, John R.; Shams, Khawaja S.; Maimone, Mark W.

    2012-01-01

    Keeping track of sequences onboard a spacecraft is challenging. When reviewing Event Verification Records (EVRs) of sequence executions on the Mars Exploration Rover (MER), operators often found themselves wondering which version of a named sequence the EVR corresponded to. The lack of this information drastically impacts the operators diagnostic capabilities as well as their situational awareness with respect to the commands the spacecraft has executed, since the EVRs do not provide argument values or explanatory comments. Having this information immediately available can be instrumental in diagnosing critical events and can significantly enhance the overall safety of the spacecraft. This software provides auditing capability that can eliminate that uncertainty while diagnosing critical conditions. Furthermore, the Restful interface provides a simple way for sequencing tools to automatically retrieve binary compiled sequence SCMFs (Space Command Message Files) on demand. It also enables developers to change the underlying database, while maintaining the same interface to the existing applications. The logging capabilities are also beneficial to operators when they are trying to recall how they solved a similar problem many days ago: this software enables automatic recovery of SCMF and RML (Robot Markup Language) sequence files directly from the command EVRs, eliminating the need for people to find and validate the corresponding sequences. To address the lack of auditing capability for sequences onboard a spacecraft during earlier missions, extensive logging support was added on the Mars Science Laboratory (MSL) sequencing server. This server is responsible for generating all MSL binary SCMFs from RML input sequences. The sequencing server logs every SCMF it generates into a MySQL database, as well as the high-level RML file and dictionary name inputs used to create the SCMF. The SCMF is then indexed by a hash value that is automatically included in all command

  4. Spatiotemporal correlations of aftershock sequences

    CERN Document Server

    Peixoto, Tiago P; Davidsen, Jörn

    2010-01-01

    Aftershock sequences are of particular interest in seismic research since they may condition seismic activity in a given region over long time spans. While they are typically identified with periods of enhanced seismic activity after a large earthquake as characterized by the Omori law, our knowledge of the spatiotemporal correlations between events in an aftershock sequence is limited. Here, we study the spatiotemporal correlations of two aftershock sequences form California (Parkfield and Hector Mine) using the recently introduced concept of "recurrent" events. We find that both sequences have very similar properties and that most of them are captured by the space-time epidemic-type aftershock sequence (ETAS) model if one takes into account catalog incompleteness. However, the stochastic model does not capture the spatiotemporal correlations leading to the observed structure of seismicity on small spatial scales.

  5. Multilocus sequence typing of total-genome-sequenced bacteria.

    Science.gov (United States)

    Larsen, Mette V; Cosentino, Salvatore; Rasmussen, Simon; Friis, Carsten; Hasman, Henrik; Marvig, Rasmus Lykke; Jelsbak, Lars; Sicheritz-Pontén, Thomas; Ussery, David W; Aarestrup, Frank M; Lund, Ole

    2012-04-01

    Accurate strain identification is essential for anyone working with bacteria. For many species, multilocus sequence typing (MLST) is considered the "gold standard" of typing, but it is traditionally performed in an expensive and time-consuming manner. As the costs of whole-genome sequencing (WGS) continue to decline, it becomes increasingly available to scientists and routine diagnostic laboratories. Currently, the cost is below that of traditional MLST. The new challenges will be how to extract the relevant information from the large amount of data so as to allow for comparison over time and between laboratories. Ideally, this information should also allow for comparison to historical data. We developed a Web-based method for MLST of 66 bacterial species based on WGS data. As input, the method uses short sequence reads from four sequencing platforms or preassembled genomes. Updates from the MLST databases are downloaded monthly, and the best-matching MLST alleles of the specified MLST scheme are found using a BLAST-based ranking method. The sequence type is then determined by the combination of alleles identified. The method was tested on preassembled genomes from 336 isolates covering 56 MLST schemes, on short sequence reads from 387 isolates covering 10 schemes, and on a small test set of short sequence reads from 29 isolates for which the sequence type had been determined by traditional methods. The method presented here enables investigators to determine the sequence types of their isolates on the basis of WGS data. This method is publicly available at www.cbs.dtu.dk/services/MLST. PMID:22238442

  6. Modelling and Simulation of VSC-HVDC Connection for Wind Power Plants

    DEFF Research Database (Denmark)

    Chaudhary, Sanjay Kumar; Teodorescu, Remus; Rodriguez, Pedro;

    2009-01-01

    step-up transformers. VSC's are modelled using ideal IGBT switches supplied by the gate pulses from their respective controllers. A sequence of operation has been simulated from the starting up of the VSC-HVDC transmission, energizing the offshore grid and subsequent synchronization of the individual......This paper describes the modelling and simulation of offshore wind power plants (WPP) connected to the onshore power system grid by VSC based HVDC transmission. Offshore wind power plant is modelled with several wind turbine generators connected to two separate collector buses with their own plant...

  7. The solar-coffee connection

    Energy Technology Data Exchange (ETDEWEB)

    Wright, G.

    2000-04-01

    Coffee connoisseurs, when they quaff a cup of coffee or enjoy a jug of joe, don't generally consider the costs to the environment of their favorite beverage. But the fact is that traditional coffee production is hard on the environment, exacting a toll on the native forests and waterways of Central America and on the migratory birds of the western hemisphere. Coffee growing is the second greatest cause of rainforest destruction after cattle ranching, because a lot of trees are cut down to dry the freshly-picked coffee crop. But espresso-sipping environmentalists and an eco-conscious Joe Public can take comfort in a promising new connection between solar energy and rainforest-friendly coffee--solar-dried coffee. And they can take pleasure in it too, because solar-dried coffee, according to virtually everyone who tries it, is the best-tasting coffee made. Considering that coffee is the second most-traded commodity next to oil, and the second most popular beverage in the world next to water, consumed by billions of people, any new process that reduces the environmental damage occasioned by coffee-growing and processing is significant.

  8. QED on the connection machine

    International Nuclear Information System (INIS)

    Physicists believe that the world is described in terms of gauge theories. A popular technique for investigating these theories is to discretize them onto a lattice and simulate numerically by a computer, yielding so-called lattice gauge theory. Such computations require at least 1014 floating-point operations, necessitating the use of advanced architecture supercomputers such as the Connection Machine. Currently the most important gauge theory to be solved is that describing the sub-nuclear world of high energy physics: quantum chromo-dynamics (QCD). The simplest example of a gauge theory is Quantum electro-dynamics (QED), the theory which describes the interaction of electrons and photons. Simulation of QCD requires computer software very similar to that for the simpler QED problem. The authors' current QED code achieves a computational rate of 1.6 million lattice site updates per second for a Monte Carlo algorithm, and 7.4 million site updates per second for a microcanonical algorithm. The estimate performance for a Monte Carlo QCD code is 200,000 site updates per second (or 5.6 Gflops/sec)

  9. IMPROVED NETWORK CONNECTIVITY IN MANETS

    Directory of Open Access Journals (Sweden)

    B R Sujatha

    2009-10-01

    Full Text Available The growth in wireless communication technologies has resulted in a considerable amount ofattention given to mobile adhoc networks. All mobile hosts in an adhoc network are embedded withpacket forwarding capabilities. It is decentralized and is independent of infrastructure. Since mobilehosts in an adhoc network usually move freely, the topology of the network changes dynamically anddisconnection occurs frequently. These characteristics require the routing protocols to find analternative path towards the destination for data transfer. The existing on-demand routing protocolsdoes the alternative path establishment only after the disconnection of links in the existing path. Thedata sent by the source during alternate path establishment period will be lost leading to incompletedata transfer. The network traffic will therefore increase considerably. This problem can be overcomeby establishing an alternative path when the existing path is more likely to be broken, by sending awarning message to the source indicating the likelihood of disconnection. In this paper an attempt hasbeen made to analyze a protocol that improves the network connectivity by preempting the alternativepath before the existing link gets failed by monitoring the signal strength and ‘age of the path’.

  10. Cortical attractor network dynamics with diluted connectivity.

    Science.gov (United States)

    Rolls, Edmund T; Webb, Tristan J

    2012-01-24

    The connectivity of the cerebral cortex is diluted, with the probability of excitatory connections between even nearby pyramidal cells rarely more than 0.1, and in the hippocampus 0.04. To investigate the extent to which this diluted connectivity affects the dynamics of attractor networks in the cerebral cortex, we simulated an integrate-and-fire attractor network taking decisions between competing inputs with diluted connectivity of 0.25 or 0.1, and with the same number of synaptic connections per neuron for the recurrent collateral synapses within an attractor population as for full connectivity. The results indicated that there was less spiking-related noise with the diluted connectivity in that the stability of the network when in the spontaneous state of firing increased, and the accuracy of the correct decisions increased. The decision times were a little slower with diluted than with complete connectivity. Given that the capacity of the network is set by the number of recurrent collateral synaptic connections per neuron, on which there is a biological limit, the findings indicate that the stability of cortical networks, and the accuracy of their correct decisions or memory recall operations, can be increased by utilizing diluted connectivity and correspondingly increasing the number of neurons in the network, with little impact on the speed of processing of the cortex. Thus diluted connectivity can decrease cortical spiking-related noise. In addition, we show that the Fano factor for the trial-to-trial variability of the neuronal firing decreases from the spontaneous firing state value when the attractor network makes a decision. This article is part of a Special Issue entitled "Neural Coding". PMID:21875702

  11. Regularities in the E.coli promoters composition in connection with the DNA strands interaction and promoter activity

    Institute of Scientific and Technical Information of China (English)

    BEREZHNOY Andrey Yu; SHCKORBATOV Yuriy G.; HISANORI Kiryu

    2006-01-01

    The energy of interaction between DNA strands in promoters is of great functional importance. Visualization of the energy of DNA strands distribution in promoter sequences was achieved. The separation of promoters in groups by their energetic properties enables evaluation of the dependence of promoter strength on the energetic properties. The analysis of groups (clusters)of promoters distributed by the energy of DNA strands interaction in -55, -35, -10 and +6 sequences indicates their connection with the transcriptional activity.

  12. Role of connecting loop I in catalysis and allosteric regulation of human glucokinase.

    Science.gov (United States)

    Martinez, Juliana A; Larion, Mioara; Conejo, Maria S; Porter, Carol M; Miller, Brian G

    2014-07-01

    Glucokinase (GCK, hexokinase IV) is a monomeric enzyme with a single glucose binding site that displays steady-state kinetic cooperativity, a functional characteristic that affords allosteric regulation of GCK activity. Structural evidence suggests that connecting loop I, comprised of residues 47-71, facilitates cooperativity by dictating the rate and scope of motions between the large and small domains of GCK. Here we investigate the impact of varying the length and amino acid sequence of connecting loop I upon GCK cooperativity. We find that sequential, single amino acid deletions from the C-terminus of connecting loop I cause systematic decreases in cooperativity. Deleting up to two loop residues leaves the kcat value unchanged; however, removing three or more residues reduces kcat by 1000-fold. In contrast, the glucose K0.5 and KD values are unaffected by shortening the connecting loop by up to six residues. Substituting alanine or glycine for proline-66, which adopts a cis conformation in some GCK crystal structures, does not alter cooperativity, indicating that cis/trans isomerization of this loop residue does not govern slow conformational reorganizations linked to hysteresis. Replacing connecting loop I with the corresponding loop sequence from the catalytic domain of the noncooperative isozyme human hexokinase I (HK-I) eliminates cooperativity without impacting the kcat and glucose K0.5 values. Our results indicate that catalytic turnover requires a minimal length of connecting loop I, whereas the loop has little impact upon the binding affinity of GCK for glucose. We propose a model in which the primary structure of connecting loop I affects cooperativity by influencing conformational dynamics, without altering the equilibrium distribution of GCK conformations. PMID:24723372

  13. Ossification sequence heterochrony among amphibians.

    Science.gov (United States)

    Harrington, Sean M; Harrison, Luke B; Sheil, Christopher A

    2013-01-01

    Heterochrony is an important mechanism in the evolution of amphibians. Although studies have centered on the relationship between size and shape and the rates of development, ossification sequence heterochrony also may have been important. Rigorous, phylogenetic methods for assessing sequence heterochrony are relatively new, and a comprehensive study of the relative timing of ossification of skeletal elements has not been used to identify instances of sequence heterochrony across Amphibia. In this study, a new version of the program Parsimov-based genetic inference (PGi) was used to identify shifts in ossification sequences across all extant orders of amphibians, for all major structural units of the skeleton. PGi identified a number of heterochronic sequence shifts in all analyses, the most interesting of which seem to be tied to differences in metamorphic patterns among major clades. Early ossification of the vomer, premaxilla, and dentary is retained by Apateon caducus and members of Gymnophiona and Urodela, which lack the strongly biphasic development seen in anurans. In contrast, bones associated with the jaws and face were identified as shifting late in the ancestor of Anura. The bones that do not shift late, and thereby occupy the earliest positions in the anuran cranial sequence, are those in regions of the skull that undergo the least restructuring throughout anuran metamorphosis. Additionally, within Anura, bones of the hind limb and pelvic girdle were also identified as shifting early in the sequence of ossification, which may be a result of functional constraints imposed by the drastic metamorphosis of most anurans.

  14. Variational Sequences, Representation Sequences and Applications in Physics

    OpenAIRE

    Palese, Marcella; Rossi, Olga; Winterroth, Ekkehart; Musilová, Jana

    2015-01-01

    This paper is a review containing new original results on the finite order variational sequence and its different representations with emphasis on applications in the theory of variational symmetries and conservation laws in physics.

  15. Super Connectivity of Line Graphs and Digraphs

    Institute of Scientific and Technical Information of China (English)

    Min Lü; Jun-Ming Xu

    2006-01-01

    The h-super connectivity κh and the h-super edge-connectivity λh are more refined network reliability indices than the connectivity and the edge-connectivity. This paper shows that for a connected balanced digraph D and its line digraph L, if D is optimally super edge-connected, then κ1(L) = 2λ1(D), and that for a connected graph G and its line graph L, if one of κ1(L) and λ2(G) exists, then κ1(L) = λ2(G). This paper determines that κ1 (B(d, n)) is equal to 4d - 8 for n = 2 and d ≥ 4, and to 4d - 4 for n ≥ 3 and d ≥ 3, and that κ1(K(d,n)) is equal to 4d- 4 for d ≥ 2 and n ≥ 2 except K(2,2). It then follows that B(d,n) and K(d,n) are both super connected for any d ≥ 2 and n ≥ 1.

  16. Quick-Connect Heavy-Duty Fastener

    Science.gov (United States)

    Moore, D. M.

    1986-01-01

    Attaching device combines fast connection and disconnection with high strength. T-shaped stud engages groove in receptacle after one-quarter turn. Further turning tightens nut on receptacle. Like quarter-turn attaching devices, connected and disconnected quickly. Like threaded devices, adjusted to desired preload, withstand high loads, and accommodate wide range of grip lengths.

  17. Connect the Book. George Washington's Teeth

    Science.gov (United States)

    Brodie, Carolyn S.

    2005-01-01

    February celebrates both National Children's Dental Health Month and President's Day (February 21), so this month's "Connect the Book" column features a book with connections to both events. George Washington, the first President of the United States (1789-1797) and known as the "Father of Our Country," had a serious dental health problem that…

  18. Supervision, Staff Development, and Evaluation Connections.

    Science.gov (United States)

    McQuarrie, Frank O.; Wood, Fred H.

    1991-01-01

    Examines the relationship between supervision, staff development, and teacher evaluation, discussing why educators must strive to make connections among the three, identifying important misunderstandings about them, and describing the purposes of each process and the similarities, differences, and connections between them. Together, they can be…

  19. Strong Connections and Invertible Weak Entwining Structures

    Institute of Scientific and Technical Information of China (English)

    J.N.ALONSO (A)LVAREZ; J.M.FERN(A)NDEZ VILABOA; R.GONZ(A)LEZ RODR(I)GUEZ

    2012-01-01

    In this paper we obtain a criterion under which the bijectivity of the canonical morphism of a weak Galois extension associated to a weak invertible entwining structure is equivalent to the existence of a strong connection form.Also we obtain an explicit formula for a strong connection under equivariant projective conditions or under coseparability conditions.

  20. A Random Walk: Stumbling across Connections

    Science.gov (United States)

    Wasserman, Nicholas H.

    2015-01-01

    Finding and designing tasks that allow for students to make connections among mathematical ideas is important for mathematics educators. One such task, which affords students the opportunity to make connections and engage with significant mathematical ideas through a variety of problem-solving approaches, is described in this article. Three…

  1. Connecting Functions in Geometry and Algebra

    Science.gov (United States)

    Steketee, Scott; Scher, Daniel

    2016-01-01

    One goal of a mathematics education is that students make significant connections among different branches of mathematics. Connections--such as those between arithmetic and algebra, between two-dimensional and three-dimensional geometry, between compass-and-straight-edge constructions and transformations, and between calculus and analytic…

  2. Physical Science Connected Classrooms: Case Studies

    Science.gov (United States)

    Irving, Karen; Sanalan, Vehbi; Shirley, Melissa

    2009-01-01

    Case-study descriptions of secondary and middle school classrooms in diverse contexts provide examples of how teachers implement connected classroom technology to facilitate formative assessment in science instruction. Connected classroom technology refers to a networked system of handheld devices designed for classroom use. Teachers were…

  3. Water Treatment Technology - Cross-Connections.

    Science.gov (United States)

    Ross-Harrington, Melinda; Kincaid, G. David

    One of twelve water treatment technology units, this student manual on cross connections provides instructional materials for two competencies. (The twelve units are designed for a continuing education training course for public water supply operators.) The competencies focus on cross connections terminology and control devices. For each…

  4. Are we connected? : Ports in Global Networks

    NARCIS (Netherlands)

    R.A. Zuidwijk (Rob)

    2015-01-01

    markdownabstractAbstract Global supply chains are built on organizational, information, and logistics networks. Ports are connected via these networks and also need to connect these networks. Synchromodality is an innovative concept for container transportation, and the port plays an important ro

  5. Connecting Representations: Using Predict, Check, Explain

    Science.gov (United States)

    Roy, George J.; Fueyo, Vivian; Vahey, Philip; Knudsen, Jennifer; Rafanan, Ken; Lara-Meloy, Teresa

    2016-01-01

    Although educators agree that making connections with the real world, as advocated by "Principles to Actions: Ensuring Mathematical Success for All" (NCTM 2014), is important, making such connections while addressing important mathematics is elusive. The authors have found that math content coupled with the instructional strategy of…

  6. Making Connections between Research and Practice

    Science.gov (United States)

    Porter, Andrew; McMaken, Jennifer

    2009-01-01

    Strengthening connections between research and practice is an important goal in education. Making the connection has both a supply side and a demand side but the demand is often ignored in education. The authors offer six hypotheses about why this situation occurs.

  7. MedlinePlus Connect: Web Application

    Science.gov (United States)

    ... in English or Spanish. MedlinePlus Connect will assume English is the language if it is not specified. If you wish ... in English or Spanish. MedlinePlus Connect will assume English is the language if it is not specified. If you wish ...

  8. Natural Connections on Riemannian Product Manifolds

    CERN Document Server

    Gribacheva, Dobrinka

    2011-01-01

    A Riemannian almost product manifold with integrable almost product structure is called a Riemannian product manifold. In the present paper the natural connections on such manifolds are studied, i.e. the linear connections preserving the almost product structure and the Riemannian metric.

  9. Making the Chromosome-Gene-Protein Connection.

    Science.gov (United States)

    Mulvihill, Charlotte

    1996-01-01

    Presents an exercise that demonstrates the chromosome-gene-protein connection using sickle-cell anemia, a genetic disease with a well-characterized molecular basis. Involves connecting changes in DNA to protein outcomes and tying them into the next generation by meiosis and gamete formation with genetic crosses. Motivates students to integrate…

  10. The Matrix Connection: Fibonacci and Inductive Proof

    Science.gov (United States)

    Veenstra, Tamara B.; Miller, Catherine M.

    2006-01-01

    This article presents several activities (some involving graphing calculators) designed to guide students to discover several interesting properties of Fibonacci numbers. Then, we explore interesting connections between Fibonacci numbers and matrices; using this connection and induction we prove divisibility properties of Fibonacci numbers.

  11. Directional connectivity in hydrology and ecology.

    Science.gov (United States)

    Larsen, Laurel G; Choi, Jungyill; Nungesser, Martha K; Harvey, Judson W

    2012-12-01

    Quantifying hydrologic and ecological connectivity has contributed to understanding transport and dispersal processes and assessing ecosystem degradation or restoration potential. However, there has been little synthesis across disciplines. The growing field of ecohydrology and recent recognition that loss of hydrologic connectivity is leading to a global decline in biodiversity underscore the need for a unified connectivity concept. One outstanding need is a way to quantify directional connectivity that is consistent, robust to variations in sampling, and transferable across scales or environmental settings. Understanding connectivity in a particular direction (e.g., streamwise, along or across gradient, between sources and sinks, along cardinal directions) provides critical information for predicting contaminant transport, planning conservation corridor design, and understanding how landscapes or hydroscapes respond to directional forces like wind or water flow. Here we synthesize progress on quantifying connectivity and develop a new strategy for evaluating directional connectivity that benefits from use of graph theory in ecology and percolation theory in hydrology. The directional connectivity index (DCI) is a graph-theory based, multiscale metric that is generalizable to a range of different structural and functional connectivity applications. It exhibits minimal sensitivity to image rotation or resolution within a given range and responds intuitively to progressive, unidirectional change. Further, it is linearly related to the integral connectivity scale length--a metric common in hydrology that correlates well with actual fluxes--but is less computationally challenging and more readily comparable across different landscapes. Connectivity-orientation curves (i.e., directional connectivity computed over a range of headings) provide a quantitative, information-dense representation of environmental structure that can be used for comparison or detection of

  12. Directional connectivity in hydrology and ecology

    Science.gov (United States)

    Larsen, Laurel G.; Choi, Jungyill; Nungesser, Martha K.; Harvey, Judson W.

    2012-01-01

    Quantifying hydrologic and ecological connectivity has contributed to understanding transport and dispersal processes and assessing ecosystem degradation or restoration potential. However, there has been little synthesis across disciplines. The growing field of ecohydrology and recent recognition that loss of hydrologic connectivity is leading to a global decline in biodiversity underscore the need for a unified connectivity concept. One outstanding need is a way to quantify directional connectivity that is consistent, robust to variations in sampling, and transferable across scales or environmental settings. Understanding connectivity in a particular direction (e.g., streamwise, along or across gradient, between sources and sinks, along cardinal directions) provides critical information for predicting contaminant transport, planning conservation corridor design, and understanding how landscapes or hydroscapes respond to directional forces like wind or water flow. Here we synthesize progress on quantifying connectivity and develop a new strategy for evaluating directional connectivity that benefits from use of graph theory in ecology and percolation theory in hydrology. The directional connectivity index (DCI) is a graph-theory based, multiscale metric that is generalizable to a range of different structural and functional connectivity applications. It exhibits minimal sensitivity to image rotation or resolution within a given range and responds intuitively to progressive, unidirectional change. Further, it is linearly related to the integral connectivity scale length—a metric common in hydrology that correlates well with actual fluxes—but is less computationally challenging and more readily comparable across different landscapes. Connectivity-orientation curves (i.e., directional connectivity computed over a range of headings) provide a quantitative, information-dense representation of environmental structure that can be used for comparison or detection of

  13. A Criterion for Regular Sequences

    Indian Academy of Sciences (India)

    D P Patil; U Storch; J Stückrad

    2004-05-01

    Let be a commutative noetherian ring and $f_1,\\ldots,f_r \\in R$. In this article we give (cf. the Theorem in $\\mathcal{x}$2) a criterion for $f_1,\\ldots,f_r$ to be regular sequence for a finitely generated module over which strengthens and generalises a result in [2]. As an immediate consequence we deduce that if $V(g_1,\\ldots,g_r) \\subseteq V(f_1,\\ldots,f_r)$ in Spec and if $f_1,\\ldots,f_r$ is a regular sequence in , then $g_1,\\ldots,g_r$ is also a regular sequence in .

  14. Algebraic connectivity of connected graphs with fixed number of pendant vertices

    CERN Document Server

    Lal, Arbind K; Sahoo, Binod K

    2010-01-01

    In this paper we consider the following problem: Over the class of all simple connected graphs of order $n$ with $k$ pendant vertices ($n,k$ being fixed), which graph maximizes (respectively, minimizes) the algebraic connectivity? We also discuss the algebraic connectivity of unicyclic graphs.

  15. Sequences of Inequalities Among Differences of Gini Means and Divergence Measures

    Directory of Open Access Journals (Sweden)

    Taneja Inder J.

    2012-12-01

    Full Text Available In 1938, Gini [3] studied a mean having two parameters. Later, many authors studied properties of this mean. In particular, it contains the famous means as harmonic, geometric, arithmetic, etc. Here we considered a sequence of inequalities arising due to particular values of each parameter of Gini’s mean. This sequence generates many nonnegative differences. Not all of them are convex. We have established new sequences of inequalities of these differences. Some refinement inequalities are also presented. Considering in terms of probability distributions these differences, we have made connections with some well known divergence measures.

  16. Three-Phase Multiple Harmonic Sequence Detection Based on Generalized Delayed Signal Superposition

    DEFF Research Database (Denmark)

    Lu, Yong; Xiao, Guochun; Wang, Xiongfei;

    2016-01-01

    multiple harmonic sequence detection method is proposed for estimating both the fundamental and harmonic sequence components under adverse grid conditions. This detection method is denoted as MG DSS-PLL since it contains Multiple Generalized Delayed Signal Superposition operators and a Phase-Locked Loop......Grid synchronization has always been an important challenge for three-phase grid-connected converters under unbalanced and distorted grid conditions. Moreover, how to quickly and accurately extract multiple harmonic sequence information is essential for control systems. In this paper, a three-phase...

  17. Connecting multimodality in human communication

    Directory of Open Access Journals (Sweden)

    Christina eRegenbogen

    2013-11-01

    Full Text Available A successful reciprocal evaluation of social signals serves as a prerequisite for social coherence and empathy. In a previous fMRI study we studied naturalistic communication situations by presenting video clips to our participants and recording their behavioral responses regarding empathy and its components. In two conditions, all three channels transported congruent emotional or neutral information, respectively. Three conditions selectively presented two emotional channels and one neutral channel and were thus bimodally emotional. We reported channel-specific emotional contributions in modality-related areas, elicited by dynamic video clips with varying combinations of emotionality in facial expressions, prosody, and speech content. However, to better understand the underlying mechanisms accompanying a naturalistically displayed human social interaction in some key regions that presumably serve as specific processing hubs for facial expressions, prosody, and speech content, we pursued a reanalysis of the data. In addition to this specificity of these regions to information channels we demonstrated that they were also sensitive to variations of the respective emotional content.Here, we focused on two different descriptions of temporal characteristics within these three modality-related regions (right fusiform gyrus (FFG, left auditory cortex (AC, left angular gyrus (AG and left dorsomedial prefrontal cortex (dmPFC. By means of a finite impulse response (FIR analysis within each of the three regions we examined the post-stimulus time-courses as a description of the temporal characteristics of the BOLD response during the video clips. Second, effective connectivity between these areas and the left dmPFC was analyzed using dynamic causal modeling (DCM in order to describe condition-related modulatory influences on the coupling between these regions. The FIR analysis showed initially diminished activation in bimodally emotional conditions but

  18. Connectiveness and civility in online learning.

    Science.gov (United States)

    Rieck, Susan; Crouch, Laura

    2007-11-01

    As the classroom shifts from teacher-centered to learner-centered and from face-to-face to online, nursing faculty members are challenged to promote a sense of connectiveness and social interaction. Making connectiveness more elusive is the perception of rude, impolite, or unkind communication. The purpose of this descriptive-exploratory study was to examine perceptions of connectiveness and civility in online nursing courses. Ninety-six students in four nursing programs participated in the study. Strategies that promote connectiveness with peers are in-person activities whenever possible and discussion assignments that include social activities. Timely feedback when responding to questions and prompt grading are important for student-to-instructor connectiveness. Thirty-five percent of the students encountered rude or unkind communication with peers, and 60% reported incivility from instructors. Their suggestions for effective handling of rude communication included addressing the behavior privately, giving guidance about netiquette, and defining what constitutes rude behavior. PMID:17765016

  19. Spin connection and renormalization of teleparallel action

    Energy Technology Data Exchange (ETDEWEB)

    Krssak, Martin; Pereira, J.G. [Universidade Estadual Paulista, Instituto de Fisica Teorica, Sao Paulo, SP (Brazil)

    2015-11-15

    In general relativity, inertia and gravitation are both included in the Levi-Civita connection. As a consequence, the gravitational action, as well as the corresponding energy-momentum density, are in general contaminated by spurious contributions coming from inertial effects. In teleparallel gravity, on the other hand, because the spin connection represents inertial effects only, it is possible to separate inertia from gravitation. Relying on this property, it is shown that to each tetrad there is naturally associated a spin connection that locally removes the inertial effects from the action. The use of the appropriate spin connection can be viewed as a renormalization process in the sense that the computation of energy and momentum naturally yields the physically relevant values. A self-consistent method for solving field equations and determining the appropriate spin connection is presented. (orig.)

  20. Spin connection and renormalization of teleparallel action

    Energy Technology Data Exchange (ETDEWEB)

    Krššák, Martin, E-mail: krssak@ift.unesp.br; Pereira, J. G., E-mail: jpereira@ift.unesp.br [Instituto de Física Teórica, Universidade Estadual Paulista, R. Dr. Bento Teobaldo Ferraz 271, 01140-070, São Paulo, SP (Brazil)

    2015-10-31

    In general relativity, inertia and gravitation are both included in the Levi–Civita connection. As a consequence, the gravitational action, as well as the corresponding energy–momentum density, are in general contaminated by spurious contributions coming from inertial effects. In teleparallel gravity, on the other hand, because the spin connection represents inertial effects only, it is possible to separate inertia from gravitation. Relying on this property, it is shown that to each tetrad there is naturally associated a spin connection that locally removes the inertial effects from the action. The use of the appropriate spin connection can be viewed as a renormalization process in the sense that the computation of energy and momentum naturally yields the physically relevant values. A self-consistent method for solving field equations and determining the appropriate spin connection is presented.

  1. New Orthogonal Small Set Kasami Code Sequence

    OpenAIRE

    I Nyoman Pramaita; I G.A.G.K. Diafari; DNKP Negara; Agus Dharma

    2015-01-01

    In this paper, the authors propose the design of a new orthogonal small set Kasami code sequence generated using combination of non-orthogonal m-sequence and small set Kasami code sequence. The authors demonstrate that the proposed code sequence has comparable auto-correlation function (ACF), cross- correlation function (CCF), peak cross-correlation values with that of the existing orthogonal small set Kasami code sequence. Though the proposed code sequence has less code sequence sets than th...

  2. Connecting network properties of rapidly disseminating epizoonotics.

    Directory of Open Access Journals (Sweden)

    Ariel L Rivas

    Full Text Available To effectively control the geographical dissemination of infectious diseases, their properties need to be determined. To test that rapid microbial dispersal requires not only susceptible hosts but also a pre-existing, connecting network, we explored constructs meant to reveal the network properties associated with disease spread, which included the road structure.Using geo-temporal data collected from epizoonotics in which all hosts were susceptible (mammals infected by Foot-and-mouth disease virus, Uruguay, 2001; birds infected by Avian Influenza virus H5N1, Nigeria, 2006, two models were compared: 1 'connectivity', a model that integrated bio-physical concepts (the agent's transmission cycle, road topology into indicators designed to measure networks ('nodes' or infected sites with short- and long-range links, and 2 'contacts', which focused on infected individuals but did not assess connectivity.THE CONNECTIVITY MODEL SHOWED FIVE NETWORK PROPERTIES: 1 spatial aggregation of cases (disease clusters, 2 links among similar 'nodes' (assortativity, 3 simultaneous activation of similar nodes (synchronicity, 4 disease flows moving from highly to poorly connected nodes (directionality, and 5 a few nodes accounting for most cases (a "20:80" pattern. In both epizoonotics, 1 not all primary cases were connected but at least one primary case was connected, 2 highly connected, small areas (nodes accounted for most cases, 3 several classes of nodes were distinguished, and 4 the contact model, which assumed all primary cases were identical, captured half the number of cases identified by the connectivity model. When assessed together, the synchronicity and directionality properties explained when and where an infectious disease spreads.Geo-temporal constructs of Network Theory's nodes and links were retrospectively validated in rapidly disseminating infectious diseases. They distinguished classes of cases, nodes, and networks, generating information usable

  3. ISIS Individualized Support In Sequencing

    NARCIS (Netherlands)

    Drachsler, Hendrik; Hummel, Hans

    2007-01-01

    Drachsler, H., & Hummel, H. G. K. (2007). ISIS Individualized Support In Sequencing. Presentation given during the PIP meeting on March 22, 2007. Open University of the Netherlands: Heerlen, The Netherlands.

  4. DNA Sequencing Using capillary Electrophoresis

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Barry Karger

    2011-05-09

    The overall goal of this program was to develop capillary electrophoresis as the tool to be used to sequence for the first time the Human Genome. Our program was part of the Human Genome Project. In this work, we were highly successful and the replaceable polymer we developed, linear polyacrylamide, was used by the DOE sequencing lab in California to sequence a significant portion of the human genome using the MegaBase multiple capillary array electrophoresis instrument. In this final report, we summarize our efforts and success. We began our work by separating by capillary electrophoresis double strand oligonucleotides using cross-linked polyacrylamide gels in fused silica capillaries. This work showed the potential of the methodology. However, preparation of such cross-linked gel capillaries was difficult with poor reproducibility, and even more important, the columns were not very stable. We improved stability by using non-cross linked linear polyacrylamide. Here, the entangled linear chains could move when osmotic pressure (e.g. sample injection) was imposed on the polymer matrix. This relaxation of the polymer dissipated the stress in the column. Our next advance was to use significantly lower concentrations of the linear polyacrylamide that the polymer could be automatically blown out after each run and replaced with fresh linear polymer solution. In this way, a new column was available for each analytical run. Finally, while testing many linear polymers, we selected linear polyacrylamide as the best matrix as it was the most hydrophilic polymer available. Under our DOE program, we demonstrated initially the success of the linear polyacrylamide to separate double strand DNA. We note that the method is used even today to assay purity of double stranded DNA fragments. Our focus, of course, was on the separation of single stranded DNA for sequencing purposes. In one paper, we demonstrated the success of our approach in sequencing up to 500 bases. Other

  5. Guitars, Violins, and Geometric Sequences

    Science.gov (United States)

    Barger, Rita; Haehl, Martha

    2007-01-01

    This article describes middle school mathematics activities that relate measurement, ratios, and geometric sequences to finger positions or the placement of frets on stringed musical instruments. (Contains 2 figures and 2 tables.)

  6. Classification of Base Sequences (+1,

    Directory of Open Access Journals (Sweden)

    Dragomir Ž. Ðoković

    2010-01-01

    Full Text Available Base sequences BS(+1, are quadruples of {±1}-sequences (;;;, with A and B of length +1 and C and D of length n, such that the sum of their nonperiodic autocor-relation functions is a -function. The base sequence conjecture, asserting that BS(+1, exist for all n, is stronger than the famous Hadamard matrix conjecture. We introduce a new definition of equivalence for base sequences BS(+1, and construct a canonical form. By using this canonical form, we have enumerated the equivalence classes of BS(+1, for ≤30. As the number of equivalence classes grows rapidly (but not monotonically with n, the tables in the paper cover only the cases ≤13.

  7. The Conditional Sequence Information Function

    Directory of Open Access Journals (Sweden)

    Osman Guzide

    2010-01-01

    Full Text Available Problem statement: A great deal of attention has been given to the theory of information. It has found its applications in science especially in the area of Biothecnology. Previous studies on the subject has been limited to either conditional or sequence problem solving. This study combines both conditional and sequence properties of the information function. By doing this, researchers can find solutions to more problems that are applicable in real life. Approach: First, properties of the dynamical systems and the information function defined by Shannon has been provided, Then, the conditional sequence information function of a dynamical system together with its proof was presented. Result: This new function now exists now and ready for the use in many real life problems such as finding solutions to DNA sequence with conditional sickness. Conclusion: This new function created opens a new avenue to researches in solving more complex problems by using its developed properties.

  8. Mining protein sequences for motifs.

    Science.gov (United States)

    Narasimhan, Giri; Bu, Changsong; Gao, Yuan; Wang, Xuning; Xu, Ning; Mathee, Kalai

    2002-01-01

    We use methods from Data Mining and Knowledge Discovery to design an algorithm for detecting motifs in protein sequences. The algorithm assumes that a motif is constituted by the presence of a "good" combination of residues in appropriate locations of the motif. The algorithm attempts to compile such good combinations into a "pattern dictionary" by processing an aligned training set of protein sequences. The dictionary is subsequently used to detect motifs in new protein sequences. Statistical significance of the detection results are ensured by statistically determining the various parameters of the algorithm. Based on this approach, we have implemented a program called GYM. The Helix-Turn-Helix motif was used as a model system on which to test our program. The program was also extended to detect Homeodomain motifs. The detection results for the two motifs compare favorably with existing programs. In addition, the GYM program provides a lot of useful information about a given protein sequence. PMID:12487759

  9. Modified Genetic Algorithm for DNA Sequence Assembly by Shotgun and Hybridization Sequencing Techniques

    OpenAIRE

    Prof.Narayan Kumar Sahu; Prof.Somesh Dewangan; Prof.Akash Wanjari

    2012-01-01

    Since the advent of rapid DNA sequencing methods in 1976, scientists have had the problem of inferring DNA sequences from sequenced fragments. Shotgun sequencing is a well-established biological and computational method used in practice. Many conventional algorithms for shotgun sequencing are based on the notion of pair wise fragment overlap. While shotgun sequencing infers a DNA sequence given the sequences of overlapping fragments, a recent and complementary method, called sequencing by hy...

  10. Sequence diversity and functional conformity

    OpenAIRE

    de Lange, Orlando

    2015-01-01

    At least four phylogenetically distinct groups of bacteria encode repeat proteins with the common ability to bind specific DNA sequences with a unique but conserved code. Each repeat binds a single DNA base, and specificity is determined by the amino acid residue at position 13 of each repeat. Repeats are typically 33-35 amino acids long. Comparing repeat sequences across all groups reveals that only three positions are hyper-conserved. Repeats are in most cases functionally compatible such t...

  11. On train track splitting sequences

    CERN Document Server

    Masur, Howard; Schleimer, Saul

    2010-01-01

    We show that the subsurface projection of a train track splitting sequence is an unparameterized quasi-geodesic in the curve complex of the subsurface. For the proof we introduce induced tracks, efficient position, and wide curves. This result is an important step in the proof that the disk complex is Gromov hyperbolic. As another application we show that train track sliding and splitting sequences give quasi-geodesics in the train track graph, generalizing a result of Hamenstaedt [Invent. Math.].

  12. Integrated sequence analysis. Final report

    International Nuclear Information System (INIS)

    The NKS/RAK subprojet 3 'integrated sequence analysis' (ISA) was formulated with the overall objective to develop and to test integrated methodologies in order to evaluate event sequences with significant human action contribution. The term 'methodology' denotes not only technical tools but also methods for integration of different scientific disciplines. In this report, we first discuss the background of ISA and the surveys made to map methods in different application fields, such as man machine system simulation software, human reliability analysis (HRA) and expert judgement. Specific event sequences were, after the surveys, selected for application and testing of a number of ISA methods. The event sequences discussed in the report were cold overpressure of BWR, shutdown LOCA of BWR, steam generator tube rupture of a PWR and BWR disturbed signal view in the control room after an external event. Different teams analysed these sequences by using different ISA and HRA methods. Two kinds of results were obtained from the ISA project: sequence specific and more general findings. The sequence specific results are discussed together with each sequence description. The general lessons are discussed under a separate chapter by using comparisons of different case studies. These lessons include areas ranging from plant safety management (design, procedures, instrumentation, operations, maintenance and safety practices) to methodological findings (ISA methodology, PSA,HRA, physical analyses, behavioural analyses and uncertainty assessment). Finally follows a discussion about the project and conclusions are presented. An interdisciplinary study of complex phenomena is a natural way to produce valuable and innovative results. This project came up with structured ways to perform ISA and managed to apply the in practice. The project also highlighted some areas where more work is needed. In the HRA work, development is required for the use of simulators and expert judgement as

  13. Structural complexity of DNA sequence.

    Science.gov (United States)

    Liou, Cheng-Yuan; Tseng, Shen-Han; Cheng, Wei-Chen; Tsai, Huai-Ying

    2013-01-01

    In modern bioinformatics, finding an efficient way to allocate sequence fragments with biological functions is an important issue. This paper presents a structural approach based on context-free grammars extracted from original DNA or protein sequences. This approach is radically different from all those statistical methods. Furthermore, this approach is compared with a topological entropy-based method for consistency and difference of the complexity results. PMID:23662161

  14. Structural Complexity of DNA Sequence

    Directory of Open Access Journals (Sweden)

    Cheng-Yuan Liou

    2013-01-01

    Full Text Available In modern bioinformatics, finding an efficient way to allocate sequence fragments with biological functions is an important issue. This paper presents a structural approach based on context-free grammars extracted from original DNA or protein sequences. This approach is radically different from all those statistical methods. Furthermore, this approach is compared with a topological entropy-based method for consistency and difference of the complexity results.

  15. Some results on homoclinic and heteroclinic connections in planar systems

    International Nuclear Information System (INIS)

    Consider a family of planar systems depending on two parameters (n, b) and having at most one limit cycle. Assume that the limit cycle disappears at some homoclinic (or heteroclinic) connection when Φ(n, b) = 0. We present a method that allows us to obtain a sequence of explicit algebraic lower and upper bounds for the bifurcation set Φ(n, b) = 0. The method is applied to two quadratic families, one of them is the well-known Bogdanov–Takens system. One of the results that we obtain for this system is the bifurcation curve for small values of n. We obtain the new three terms from purely algebraic calculations, without evaluating Melnikov functions

  16. Dynamics about Neural Array with Simple Lateral Inhibitory Connections

    Institute of Scientific and Technical Information of China (English)

    Jian ZHUANG

    2011-01-01

    Lateral inhibitory effect is a well-known feature of information processing in neural systems.This paper presents a neural array model with simple lateral inhibitory connections.After detailed examining into the dynamics of this kind of neural array,the author gives the sufficient conditions under which the outputs of the network will tend to a special stable pattern called spatial sparse pattern in which if the output of a neuron is 1,then the outputs of the neurons in its neighborhood are 0.This ability called spatial sparse coding plays an important role in self-coding,self-organization and associative memory for patterns and pattern sequences.The main conclusions about the dynamics of this kind of neural array which is related to spatial sparse coding are introduced.

  17. Facilitate generation connections on Orkney by automatic distribution network management

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    This report summarises the results of a study assessing the capability and limitations of the Orkney Network under a variety of conditions of demand, generation connections, network configuration, and reactive compensation). A conceptual active management scheme (AMS) suitable for the conditions on Orkney is developed and evaluated. Details are given of a proposed framework for the design and evaluation of future active management schemes, logic control sequences for managed generation units, and a proposed evaluation method for the active management scheme. Implications of introducing the proposed AMS are examined, and the commercial aspects of an AMS and system security are considered. The existing Orkney network is described; and an overview of the SHEPDL (Scottish Hydro Electric Power Distribution Ltd.) SCADA system is presented with a discussion of AMS identification, selection, and development.

  18. Has the connection between polyploidy and diversification actually been tested?

    Science.gov (United States)

    Kellogg, Elizabeth A

    2016-04-01

    Many major clades of angiosperms have several whole genome duplications (polyploidization events) in their distant past, suggesting that polyploidy drives or at least permits diversification. However, data on recently diverged groups are more equivocal, finding little evidence of elevated diversification following polyploidy. The discrepancy may be attributable at least in part to methodology. Many studies use indirect methods, such as chromosome numbers, genome size, and Ks plots, to test polyploidy, although these approaches can be misleading, and often lack sufficient resolution. A direct test of diversification following polyploidy requires a sequence-based approach that traces the history of nuclear genomes rather than species. These methods identify the point of coalescence of ancestral genomes, but may be misleading about the time and thus the extent of diversification. Limitations of existing methods mean that the connection between polyploidy and diversification has not been rigorously tested and remains unknown.

  19. A proof of Connelly's conjecture on 3-connected generic cycles

    DEFF Research Database (Denmark)

    Berg, Alex Rune; Jordán, Tibor

    2001-01-01

    A graph G = (V , E) is called a generic circuit if |E| = 2|V| - 2 and every X ⊂ V with 2 ≥ |X| ≥ |V| - 1 satisfies i(X) ≤ 2|X| - 3. Here i(X) denotes the number of edges induced by X. The operation extension subdivides an edge uw of a graph by a new vertex v and adds a new edge vz for some vertex z...... ≠ u, w. Connelly conjectured that every 3-connected generic circuit can be obtained from K4 by a sequence of extensions. We prove this conjecture. As a corollary, we also obtain a special case of a conjecture of Hendrickson on generically globally rigid graphs....

  20. Optimization of sequence alignment for simple sequence repeat regions

    Directory of Open Access Journals (Sweden)

    Ogbonnaya Francis C

    2011-07-01

    Full Text Available Abstract Background Microsatellites, or simple sequence repeats (SSRs, are tandemly repeated DNA sequences, including tandem copies of specific sequences no longer than six bases, that are distributed in the genome. SSR has been used as a molecular marker because it is easy to detect and is used in a range of applications, including genetic diversity, genome mapping, and marker assisted selection. It is also very mutable because of slipping in the DNA polymerase during DNA replication. This unique mutation increases the insertion/deletion (INDELs mutation frequency to a high ratio - more than other types of molecular markers such as single nucleotide polymorphism (SNPs. SNPs are more frequent than INDELs. Therefore, all designed algorithms for sequence alignment fit the vast majority of the genomic sequence without considering microsatellite regions, as unique sequences that require special consideration. The old algorithm is limited in its application because there are many overlaps between different repeat units which result in false evolutionary relationships. Findings To overcome the limitation of the aligning algorithm when dealing with SSR loci, a new algorithm was developed using PERL script with a Tk graphical interface. This program is based on aligning sequences after determining the repeated units first, and the last SSR nucleotides positions. This results in a shifting process according to the inserted repeated unit type. When studying the phylogenic relations before and after applying the new algorithm, many differences in the trees were obtained by increasing the SSR length and complexity. However, less distance between different linage had been observed after applying the new algorithm. Conclusions The new algorithm produces better estimates for aligning SSR loci because it reflects more reliable evolutionary relations between different linages. It reduces overlapping during SSR alignment, which results in a more realistic

  1. Genome Sequence of Canine Herpesvirus.

    Directory of Open Access Journals (Sweden)

    Konstantinos V Papageorgiou

    Full Text Available Canine herpesvirus is a widespread alphaherpesvirus that causes a fatal haemorrhagic disease of neonatal puppies. We have used high-throughput methods to determine the genome sequences of three viral strains (0194, V777 and V1154 isolated in the United Kingdom between 1985 and 2000. The sequences are very closely related to each other. The canine herpesvirus genome is estimated to be 125 kbp in size and consists of a unique long sequence (97.5 kbp and a unique short sequence (7.7 kbp that are each flanked by terminal and internal inverted repeats (38 bp and 10.0 kbp, respectively. The overall nucleotide composition is 31.6% G+C, which is the lowest among the completely sequenced alphaherpesviruses. The genome contains 76 open reading frames predicted to encode functional proteins, all of which have counterparts in other alphaherpesviruses. The availability of the sequences will facilitate future research on the diagnosis and treatment of canine herpesvirus-associated disease.

  2. Road Weather and Connected Vehicles

    Science.gov (United States)

    Pisano, P.; Boyce, B. C.

    2015-12-01

    On average, there are over 5.8 M vehicle crashes each year of which 23% are weather-related. Weather-related crashes are defined as those crashes that occur in adverse weather or on slick pavement. The vast majority of weather-related crashes happen on wet pavement (74%) and during rainfall (46%). Connected vehicle technologies hold the promise to transform road-weather management by providing improved road weather data in real time with greater temporal and geographic accuracy. This will dramatically expand the amount of data that can be used to assess, forecast, and address the impacts that weather has on roads, vehicles, and travelers. The use of vehicle-based measurements of the road and surrounding atmosphere with other, more traditional weather data sources, and create road and atmospheric hazard products for a variety of users. The broad availability of road weather data from mobile sources will vastly improve the ability to detect and forecast weather and road conditions, and will provide the capability to manage road-weather response on specific roadway links. The RWMP is currently demonstrating how weather, road conditions, and related vehicle data can be used for decision making through an innovative Integrated Mobile Observations project. FHWA is partnering with 3 DOTs (MN, MI, & NV) to pilot these applications. One is a mobile alerts application called the Motorists Advisories and Warnings (MAW) and a maintenance decision support application. These applications blend traditional weather information (e.g., radar, surface stations) with mobile vehicle data (e.g., temperature, brake status, wiper status) to determine current weather conditions. These weather conditions, and other road-travel-relevant information, are provided to users via web and phone applications. The MAW provides nowcasts and short-term forecasts out to 24 hours while the EMDSS application can provide forecasts up to 72 hours in advance. The three DOTs have placed readers and external

  3. Detecting Functional Connectivity During Audiovisual Integration with MEG: A Comparison of Connectivity Metrics.

    Science.gov (United States)

    Ard, Tyler; Carver, Frederick W; Holroyd, Tom; Horwitz, Barry; Coppola, Richard

    2015-08-01

    In typical magnetoencephalography and/or electroencephalography functional connectivity analysis, researchers select one of several methods that measure a relationship between regions to determine connectivity, such as coherence, power correlations, and others. However, it is largely unknown if some are more suited than others for various types of investigations. In this study, the authors investigate seven connectivity metrics to evaluate which, if any, are sensitive to audiovisual integration by contrasting connectivity when tracking an audiovisual object versus connectivity when tracking a visual object uncorrelated with the auditory stimulus. The authors are able to assess the metrics' performances at detecting audiovisual integration by investigating connectivity between auditory and visual areas. Critically, the authors perform their investigation on a whole-cortex all-to-all mapping, avoiding confounds introduced in seed selection. The authors find that amplitude-based connectivity measures in the beta band detect strong connections between visual and auditory areas during audiovisual integration, specifically between V4/V5 and auditory cortices in the right hemisphere. Conversely, phase-based connectivity measures in the beta band as well as phase and power measures in alpha, gamma, and theta do not show connectivity between audiovisual areas. The authors postulate that while beta power correlations detect audiovisual integration in the current experimental context, it may not always be the best measure to detect connectivity. Instead, it is likely that the brain utilizes a variety of mechanisms in neuronal communication that may produce differential types of temporal relationships.

  4. Long-range barcode labeling-sequencing

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Feng; Zhang, Tao; Singh, Kanwar K.; Pennacchio, Len A.; Froula, Jeff L.; Eng, Kevin S.

    2016-10-18

    Methods for sequencing single large DNA molecules by clonal multiple displacement amplification using barcoded primers. Sequences are binned based on barcode sequences and sequenced using a microdroplet-based method for sequencing large polynucleotide templates to enable assembly of haplotype-resolved complex genomes and metagenomes.

  5. Pig genome sequence - analysis and publication strategy

    NARCIS (Netherlands)

    Archibald, A.L.; Bolund, L.; Churcher, C.; Fredholm, M.; Groenen, M.A.M.; Harlizius, B.

    2010-01-01

    Background - The pig genome is being sequenced and characterised under the auspices of the Swine Genome Sequencing Consortium. The sequencing strategy followed a hybrid approach combining hierarchical shotgun sequencing of BAC clones and whole genome shotgun sequencing. Results - Assemblies of the B

  6. Thread extraction for polyadic instruction sequences

    NARCIS (Netherlands)

    J.A. Bergstra; C.A. Middelburg

    2009-01-01

    Instruction sequences are often fragmented. An important reason for instruction sequence fragmentation is that the execution architecture at hand to execute instruction sequences sets bounds to the size of instruction sequences. In this paper, we study instruction sequences that have been split into

  7. Resting state functional connectivity in perfusion imaging: correlation maps with BOLD connectivity and resting state perfusion.

    Directory of Open Access Journals (Sweden)

    Roberto Viviani

    Full Text Available Functional connectivity is a property of the resting state that may provide biomarkers of brain function and individual differences. Classically, connectivity is estimated as the temporal correlation of spontaneous fluctuations of BOLD signal. We investigated differences in connectivity estimated from the BOLD and CBF signal present in volumes acquired with arterial spin labeling technique in a large sample (N = 265 of healthy individuals. Positive connectivity was observable in both BOLD and CBF signal, and was present in the CBF signal also at frequencies lower than 0.009 Hz, here investigated for the first time. Negative connectivity was more variable. The validity of positive connectivity was confirmed by the existence of correlation across individuals in its intensity estimated from the BOLD and CBF signal. In contrast, there was little or no correlation across individuals between intensity of connectivity and mean perfusion levels, suggesting that these two biomarkers correspond to distinct sources of individual differences.

  8. Mapping hydrologic connectivity of geographically isolated wetlands

    Science.gov (United States)

    Ameli, Ali; Creed, Irena

    2016-04-01

    Geographically isolated wetlands (GIWs) are characterized as depressional landscape features completely surrounded by uplands. These small and typically circular landscape features represent a vast majority of wetlands in various landscapes in North America (98% of all wetlands in the Prairie Pothole Region). Geographical isolation, however, does not imply the hydrological isolation. Although geospatial data (e.g., aerial photos) suggested that GIWs lack a persistent surface water connection, the groundwater connection between GIWs and navigable downstream waters can be substantial with large fluxes at the regional scales. The surface/subsurface connections among GIWs and between GIWs and navigable waters are difficult to map and quantify. This is intimately tied to the fact that an efficient incorporation of these small geometric features and characterization of the mechanisms behind these connectivities are challenging within grid-based simulators. We used a physically-based grid-free groundwater-surface water interaction and surface flow routing schemes to map and assess the watershed-scale GIWs connectivity within an extensively studied watershed at the Canadian prairie pothole region with high density of GIWs. The results showed that there is a persistent subsurface connectivity among GIWs and between GIWs and navigable waters. Surface connection was rare and only occurred during extreme events. The results of this paper have significant implications for developing scientifically grounded environmental policy for protection of GIWs within North American Prairie.

  9. High-Throughput Mapping of Single-Neuron Projections by Sequencing of Barcoded RNA.

    Science.gov (United States)

    Kebschull, Justus M; Garcia da Silva, Pedro; Reid, Ashlan P; Peikon, Ian D; Albeanu, Dinu F; Zador, Anthony M

    2016-09-01

    Neurons transmit information to distant brain regions via long-range axonal projections. In the mouse, area-to-area connections have only been systematically mapped using bulk labeling techniques, which obscure the diverse projections of intermingled single neurons. Here we describe MAPseq (Multiplexed Analysis of Projections by Sequencing), a technique that can map the projections of thousands or even millions of single neurons by labeling large sets of neurons with random RNA sequences ("barcodes"). Axons are filled with barcode mRNA, each putative projection area is dissected, and the barcode mRNA is extracted and sequenced. Applying MAPseq to the locus coeruleus (LC), we find that individual LC neurons have preferred cortical targets. By recasting neuroanatomy, which is traditionally viewed as a problem of microscopy, as a problem of sequencing, MAPseq harnesses advances in sequencing technology to permit high-throughput interrogation of brain circuits.

  10. Transient of power pulse and its sequence in power electronics

    Institute of Scientific and Technical Information of China (English)

    ZHAO ZhengMing; BAI Hua; YUAN LiQiang

    2007-01-01

    Various failures and destructions occur in the applications of the power electronic converter, The real practice shows that these failures are connected with the concentration of the transient power pulse. In allusion to the physical characteristics of power electronic converters, this paper proposed that the power pulse and its sequence are the basis for power electronics in the perspective of electromagnetic energy. The authors analyzed the transient processes in the power semiconductors,electric conduction loops and controller system and illustrated the power pulse phenomena in high voltage and high power inverters. This investigation on the power pulse sequence is very meaningful for the failure analysis and device protection and has become an important topic in power electronics.

  11. Transient of power pulse and its sequence in power electronics

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Various failures and destructions occur in the applications of the power electronic converter. The real practice shows that these failures are connected with the con-centration of the transient power pulse. In allusion to the physical characteristics of power electronic converters,this paper proposed that the power pulse and its se-quence are the basis for power electronics in the perspective of electromagnetic energy. The authors analyzed the transient processes in the power semiconductors,electric conduction loops and controller system and illustrated the power pulse phenomena in high voltage and high power inverters. This investigation on the power pulse sequence is very meaningful for the failure analysis and device pro-tection and has become an important topic in power electronics.

  12. Configuring Random Graph Models with Fixed Degree Sequences

    CERN Document Server

    Fosdick, Bailey K; Nishimura, Joel; Ugander, Johan

    2016-01-01

    Random graph null models have found widespread application in diverse research communities analyzing network datasets. The most popular family of random graph null models, called configuration models, are defined as uniform distributions over a space of graphs with a fixed degree sequence. Commonly, properties of an empirical network are compared to properties of an ensemble of graphs from a configuration model in order to quantify whether empirical network properties are meaningful or whether they are instead a common consequence of the particular degree sequence. In this work we study the subtle but important decisions underlying the specification of a configuration model, and investigate the role these choices play in graph sampling procedures and a suite of applications. We place particular emphasis on the importance of specifying the appropriate graph labeling---stub-labeled or vertex-labeled---under which to consider a null model, a choice that closely connects the study of random graphs to the study of...

  13. Generalized Finite Sequence of Fuzzy Topographic Topological Mapping

    Directory of Open Access Journals (Sweden)

    Tahir Ahmad

    2010-01-01

    Full Text Available Problem statement: Fuzzy Topographic Topological Mapping (FTTM was developed to solve the neuromagnetic inverse problem. FTTM consisted of four topological spaces and connected by three homeomorphisms. FTTM 1 and FTTM 2 were developed to present 3-D view of an unbounded single current source and bounded multicurrent sources, respectively. FTTM 1 and FTTM 2 were homeomorphic and this homeomorphism will generate another 14 FTTM. We conjectured if there exist n elements of FTTM, then the numbers of new elements are n4-n. Approach: In this study, the conjecture was proven by viewing FTTMs as sequence and using its geometrical features. Results: In the process, several definitions were developed, geometrical and algebraic properties of FTTM were discovered. Conclusion: The conjecture was proven and some features of the sequence appear in Pascal Triangle.

  14. Altered thalamic functional connectivity in multiple sclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Yaou; Liang, Peipeng; Duan, Yunyun; Huang, Jing; Ren, Zhuoqiong; Jia, Xiuqin [Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053 (China); Dong, Huiqing; Ye, Jing [Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053 (China); Shi, Fu-Dong [Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052 (China); Butzkueven, Helmut [Department of Medicine, University of Melbourne, Parkville 3010 (Australia); Li, Kuncheng, E-mail: kunchengli55@gmail.com [Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053 (China)

    2015-04-15

    Highlights: •We demonstrated decreased connectivity between thalamus and cortical regions in MS. •Increased intra- and inter-thalamic connectivity was also observed in MS. •The increased functional connectivity is attenuated by increasing disease duration. -- Abstract: Objective: To compare thalamic functional connectivity (FC) in patients with multiple sclerosis (MS) and healthy controls (HC), and correlate these connectivity measures with other MRI and clinical variables. Methods: We employed resting-state functional MRI (fMRI) to examine changes in thalamic connectivity by comparing thirty-five patients with MS and 35 age- and sex-matched HC. Thalamic FC was investigated by correlating low frequency fMRI signal fluctuations in thalamic voxels with voxels in all other brain regions. Additionally thalamic volume fraction (TF), T2 lesion volume (T2LV), EDSS and disease duration were recorded and correlated with the FC changes. Results: MS patients were found to have a significantly lower TF than HC in bilateral thalami. Compared to HC, the MS group showed significantly decreased FC between thalamus and several brain regions including right middle frontal and parahippocampal gyri, and the left inferior parietal lobule. Increased intra- and inter-thalamic FC was observed in the MS group compared to HC. These FC alterations were not correlated with T2LV, thalamic volume or lesions. In the MS group, however, there was a negative correlation between disease duration and inter-thalamic connectivity (r = −0.59, p < 0.001). Conclusion: We demonstrated decreased FC between thalamus and several cortical regions, while increased intra- and inter-thalamic connectivity in MS patients. These complex functional changes reflect impairments and/or adaptations that are independent of T2LV, thalamic volume or presence of thalamic lesions. The negative correlation between disease duration and inter-thalamic connectivity could indicate an adaptive role of thalamus that is

  15. Low pore connectivity in natural rock

    Science.gov (United States)

    Hu, Qinhong; Ewing, Robert P.; Dultz, Stefan

    2012-05-01

    As repositories for CO2 and radioactive waste, as oil and gas reservoirs, and as contaminated sites needing remediation, rock formations play a central role in energy and environmental management. The connectivity of the rock's porespace strongly affects fluid flow and solute transport. This work examines pore connectivity and its implications for fluid flow and chemical transport. Three experimental approaches (imbibition, tracer concentration profiles, and imaging) were used in combination with network modeling. In the imbibition results, three types of imbibition slope [log (cumulative imbibition) vs. log (imbibition time)] were found: the classical 0.5, plus 0.26, and 0.26 transitioning to 0.5. The imbibition slope of 0.26 seen in Indiana sandstone, metagraywacke, and Barnett shale indicates low pore connectivity, in contrast to the slope of 0.5 seen in the well-connected Berea sandstone. In the tracer profile work, rocks exhibited different distances to the plateau porosity, consistent with the pore connectivity from the imbibition tests. Injection of a molten metal into connected pore spaces, followed by 2-D imaging of the solidified alloy in polished thin sections, allowed direct assessment of pore structure and lateral connection in the rock samples. Pore-scale network modeling gave results consistent with measurements, confirming pore connectivity as the underlying cause of both anomalous behaviors: imbibition slope not having the classical value of 0.5, and accessible porosity being a function of distance from the edge. A poorly connected porespace will exhibit anomalous behavior in fluid flow and chemical transport, such as a lower imbibition slope (in air-water system) and diffusion rate than expected from classical behavior.

  16. Low Pore Connectivity in Natural Rock

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Qinhong; Ewing, Robert P.; Dultz, Stefan

    2012-05-15

    As repositories for CO₂ and radioactive waste, as oil and gas reservoirs, and as contaminated sites needing remediation, rock formations play a central role in energy and environmental management. The connectivity of the rock's porespace strongly affects fluid flow and solute transport. This work examines pore connectivity and its implications for fluid flow and chemical transport. Three experimental approaches (imbibition, tracer concentration profiles, and imaging) were used in combination with network modeling. In the imbibition results, three types of imbibition slope [log (cumulative imbibition) vs. log (imbibition time)] were found: the classical 0.5, plus 0.26, and 0.26 transitioning to 0.5. The imbibition slope of 0.26 seen in Indiana sandstone, metagraywacke, and Barnett shale indicates low pore connectivity, in contrast to the slope of 0.5 seen in the well-connected Berea sandstone. In the tracer profile work, rocks exhibited different distances to the plateau porosity, consistent with the pore connectivity from the imbibition tests. Injection of a molten metal into connected pore spaces, followed by 2-D imaging of the solidified alloy in polished thin sections, allowed direct assessment of pore structure and lateral connection in the rock samples. Pore-scale network modeling gave results consistent with measurements, confirming pore connectivity as the underlying cause of both anomalous behaviors: imbibition slope not having the classical value of 0.5, and accessible porosity being a function of distance from the edge. A poorly connected porespace will exhibit anomalous behavior in fluid flow and chemical transport, such as a lower imbibition slope (in air–water system) and diffusion rate than expected from classical behavior.

  17. Low pore connectivity in natural rock.

    Science.gov (United States)

    Hu, Qinhong; Ewing, Robert P; Dultz, Stefan

    2012-05-15

    As repositories for CO(2) and radioactive waste, as oil and gas reservoirs, and as contaminated sites needing remediation, rock formations play a central role in energy and environmental management. The connectivity of the rock's porespace strongly affects fluid flow and solute transport. This work examines pore connectivity and its implications for fluid flow and chemical transport. Three experimental approaches (imbibition, tracer concentration profiles, and imaging) were used in combination with network modeling. In the imbibition results, three types of imbibition slope [log (cumulative imbibition) vs. log (imbibition time)] were found: the classical 0.5, plus 0.26, and 0.26 transitioning to 0.5. The imbibition slope of 0.26 seen in Indiana sandstone, metagraywacke, and Barnett shale indicates low pore connectivity, in contrast to the slope of 0.5 seen in the well-connected Berea sandstone. In the tracer profile work, rocks exhibited different distances to the plateau porosity, consistent with the pore connectivity from the imbibition tests. Injection of a molten metal into connected pore spaces, followed by 2-D imaging of the solidified alloy in polished thin sections, allowed direct assessment of pore structure and lateral connection in the rock samples. Pore-scale network modeling gave results consistent with measurements, confirming pore connectivity as the underlying cause of both anomalous behaviors: imbibition slope not having the classical value of 0.5, and accessible porosity being a function of distance from the edge. A poorly connected porespace will exhibit anomalous behavior in fluid flow and chemical transport, such as a lower imbibition slope (in air-water system) and diffusion rate than expected from classical behavior.

  18. Task-related functional connectivity of the caudate mediates the association between trait mindfulness and implicit learning in older adults.

    Science.gov (United States)

    Stillman, Chelsea M; You, Xiaozhen; Seaman, Kendra L; Vaidya, Chandan J; Howard, James H; Howard, Darlene V

    2016-08-01

    Accumulating evidence shows a positive relationship between mindfulness and explicit cognitive functioning, i.e., that which occurs with conscious intent and awareness. However, recent evidence suggests that there may be a negative relationship between mindfulness and implicit types of learning, or those that occur without conscious awareness or intent. Here we examined the neural mechanisms underlying the recently reported negative relationship between dispositional mindfulness and implicit probabilistic sequence learning in both younger and older adults. We tested the hypothesis that the relationship is mediated by communication, or functional connectivity, of brain regions once traditionally considered to be central to dissociable learning systems: the caudate, medial temporal lobe (MTL), and prefrontal cortex (PFC). We first replicated the negative relationship between mindfulness and implicit learning in a sample of healthy older adults (60-90 years old) who completed three event-related runs of an implicit sequence learning task. Then, using a seed-based connectivity approach, we identified task-related connectivity associated with individual differences in both learning and mindfulness. The main finding was that caudate-MTL connectivity (bilaterally) was positively correlated with learning and negatively correlated with mindfulness. Further, the strength of task-related connectivity between these regions mediated the negative relationship between mindfulness and learning. This pattern of results was limited to the older adults. Thus, at least in healthy older adults, the functional communication between two interactive learning-relevant systems can account for the relationship between mindfulness and implicit probabilistic sequence learning. PMID:27121302

  19. Intensive reasoning training alters patterns of brain connectivity at rest.

    Science.gov (United States)

    Mackey, Allyson P; Miller Singley, Alison T; Bunge, Silvia A

    2013-03-13

    Patterns of correlated activity among brain regions reflect functionally relevant networks that are widely assumed to be stable over time. We hypothesized that if these correlations reflect the prior history of coactivation of brain regions, then a marked shift in cognition could alter the strength of coupling between these regions. We sought to test whether intensive reasoning training in humans would result in tighter coupling among regions in the lateral frontoparietal network, as measured with resting-state fMRI (rs-fMRI). Rather than designing an artificial training program, we studied individuals who were preparing for a standardized test that places heavy demands on relational reasoning, the Law School Admissions Test (LSAT). LSAT questions require test takers to group or sequence items according to a set of complex rules. We recruited young adults who were enrolled in an LSAT course that offers 70 h of reasoning instruction (n = 25), and age- and IQ-matched controls intending to take the LSAT in the future (n = 24). rs-fMRI data were collected for all subjects during two scanning sessions separated by 90 d. An analysis of pairwise correlations between brain regions implicated in reasoning showed that fronto-parietal connections were strengthened, along with parietal-striatal connections. These findings provide strong evidence for neural plasticity at the level of large-scale networks supporting high-level cognition. PMID:23486950

  20. Higher U(1)-gerbe connections in geometric prequantization

    Science.gov (United States)

    Fiorenza, Domenico; Rogers, Christopher L.; Schreiber, Urs

    2016-07-01

    We promote geometric prequantization to higher geometry (higher stacks), where a prequantization is given by a higher principal connection (a higher gerbe with connection). We show fairly generally how there is canonically a tower of higher gauge groupoids and Courant groupoids assigned to a higher prequantization, and establish the corresponding Atiyah sequence as an integrated Kostant-Souriau ∞-group extension of higher Hamiltonian symplectomorphisms by higher quantomorphisms. We also exhibit the ∞-group cocycle which classifies this extension and discuss how its restrictions along Hamiltonian ∞-actions yield higher Heisenberg cocycles. In the special case of higher differential geometry over smooth manifolds, we find the L∞-algebra extension of Hamiltonian vector fields — which is the higher Poisson bracket of local observables — and show that it is equivalent to the construction proposed by the second author in n-plectic geometry. Finally, we indicate a list of examples of applications of higher prequantization in the extended geometric quantization of local quantum field theories and specifically in string geometry.

  1. Bridge connection of quantum Hall elementary devices

    CERN Document Server

    Callegaro, Luca

    2013-01-01

    Multiple-series and multiple-parallel connections of quantum Hall elementary devices allow the realization of multiple or fractional values of the quantized Hall resistance, rejecting the effect of contact and wiring resistances. We introduce here the multiple-bridge connection, which maintains the properties of multiple-series and parallel connections and allows more freedom in the choice of the topology of networks composed of quantum Hall elements, and the design of more efficient quantum Hall array resistance standards (and other devices). As an example, a 5-element network is analyzed in detail.

  2. Failure Analysis of A Fractured Connecting Rod

    OpenAIRE

    Mohammed, M. N.; Omar, M. Z.; Zainuddin Sajuri; A. Salah; M.A. Abdelgnei; Salleh, M. S.

    2012-01-01

    In many cases, the major reason behind or causing catastrophic engine failure is the occurrence of the connecting-rod failure and sometimes, such a failure can be attributed to the broken connecting rod’s shank especially when there is a probability of being pushed through the side of the crank-case, thereby making the engine irreparable. Thus, the major aim of the current work is to analyze the connecting rod failure. The study applied a finite element analysis and metallographic examination...

  3. Intermittently connected mobile ad hoc networks

    CERN Document Server

    Jamalipour, Abbas

    2011-01-01

    In the last few years, there has been extensive research activity in the emerging area of Intermittently Connected Mobile Ad Hoc Networks (ICMANs). By considering the nature of intermittent connectivity in most real word mobile environments without any restrictions placed on users' behavior, ICMANs are eventually formed without any assumption with regard to the existence of a end-to-end path between two nodes wishing to communicate. It is different from the conventional Mobile Ad Hoc Networks (MANETs), which have been implicitly viewed as a connected graph with established complete paths betwe

  4. The Twisted-Cube Connected Networks

    Institute of Scientific and Technical Information of China (English)

    WANG Deqiang; ZHAO Lianchang

    1999-01-01

    This paper presents a newinterconnection network topology, called the twisted-cube connectednetwork, which is a generation of the twisted 3-cube. The twisted-cubeconnected network is a variant of the hypercube, and it has a betterrecursive structure. The regularity, connectivities, subgraphs of thetwisted-cube connected network are studied. The twisted-cube connectednetwork is proved to be a 3-cube-free network, which is the essentialdifference from the hypercube and variants of the hypercube. Anefficient routing algorithm is proposed, and the diameter ofn-dimensional twisted-cube connected network is proved to be just[n+1/2] which is less than that of the hypercube.

  5. Electrical connection structure for a superconductor element

    Science.gov (United States)

    Lallouet, Nicolas; Maguire, James

    2010-05-04

    The invention relates to an electrical connection structure for a superconductor element cooled by a cryogenic fluid and connected to an electrical bushing, which bushing passes successively through an enclosure at an intermediate temperature between ambient temperature and the temperature of the cryogenic fluid, and an enclosure at ambient temperature, said bushing projecting outside the ambient temperature enclosure. According to the invention, said intermediate enclosure is filled at least in part with a solid material of low thermal conductivity, such as a polyurethane foam or a cellular glass foam. The invention is applicable to connecting a superconductor cable at cryogenic temperature to a device for equipment at ambient temperature.

  6. Is the spin connection confined or condensed?

    CERN Document Server

    Donoghue, John F

    2016-01-01

    The spin connection enters the theory of gravity as a nonabelian gauge field associated with local Lorentz transformations. Normally it is eliminated from making an extra assumption - that of the metricity of the vierbein field. However, treated by itself with the usual gauge action, it has a negative beta function, implying that it is asymptotically free. I suggest that the spin connection could be confined (or perhaps partially confined) in the same way as other nonabelian gauge fields. This would remove the need to make the extra assumption of metricity, as the spin connection would not be present in the low energy theory, leaving the symmetry to be realized only using metric variables.

  7. Limited Genetic Connectivity between Gorgonian Morphotypes along a Depth Gradient.

    Science.gov (United States)

    Costantini, Federica; Gori, Andrea; Lopez-González, Pablo; Bramanti, Lorenzo; Rossi, Sergio; Gili, Josep-Maria; Abbiati, Marco

    2016-01-01

    Gorgonian species show a high morphological variability in relation to the environment in which they live. In coastal areas, parameters such as temperature, light, currents, and food availability vary significantly with depth, potentially affecting morphology of the colonies and the structure of the populations, as well as their connectivity patterns. In tropical seas, the existence of connectivity between shallow and deep populations supported the hypothesis that the deep coral reefs could potentially act as (reproductive) refugia fostering re-colonization of shallow areas after mortality events. Moreover, this hypothesis is not so clear accepted in temperate seas. Eunicella singularis is one of the most common gorgonian species in Northwestern Mediterranean Sea, playing an important role as ecosystem engineer by providing biomass and complexity to the coralligenous habitats. It has a wide bathymetric distribution ranging from about 10 m to 100 m. Two depth-related morphotypes have been identified, differing in colony morphology, sclerite size and shape, and occurrence of symbiotic algae, but not in mitochondrial DNA haplotypes. In the present study the genetic structure of E. singularis populations along a horizontal and bathymetric gradient was assessed using microsatellites and ITS1 sequences. Restricted gene flow was found at 30-40 m depth between the two Eunicella morphotypes. Conversely, no genetic structuring has been found among shallow water populations within a spatial scale of ten kilometers. The break in gene flow between shallow and deep populations contributes to explain the morphological variability observed at different depths. Moreover, the limited vertical connectivity hinted that the refugia hypothesis does not apply to E. singularis. Re-colonization of shallow water populations, occasionally affected by mass mortality events, should then be mainly fueled by larvae from other shallow water populations. PMID:27490900

  8. Limited Genetic Connectivity between Gorgonian Morphotypes along a Depth Gradient

    Science.gov (United States)

    Gori, Andrea; Lopez-González, Pablo; Bramanti, Lorenzo; Rossi, Sergio; Gili, Josep-Maria; Abbiati, Marco

    2016-01-01

    Gorgonian species show a high morphological variability in relation to the environment in which they live. In coastal areas, parameters such as temperature, light, currents, and food availability vary significantly with depth, potentially affecting morphology of the colonies and the structure of the populations, as well as their connectivity patterns. In tropical seas, the existence of connectivity between shallow and deep populations supported the hypothesis that the deep coral reefs could potentially act as (reproductive) refugia fostering re-colonization of shallow areas after mortality events. Moreover, this hypothesis is not so clear accepted in temperate seas. Eunicella singularis is one of the most common gorgonian species in Northwestern Mediterranean Sea, playing an important role as ecosystem engineer by providing biomass and complexity to the coralligenous habitats. It has a wide bathymetric distribution ranging from about 10 m to 100 m. Two depth-related morphotypes have been identified, differing in colony morphology, sclerite size and shape, and occurrence of symbiotic algae, but not in mitochondrial DNA haplotypes. In the present study the genetic structure of E. singularis populations along a horizontal and bathymetric gradient was assessed using microsatellites and ITS1 sequences. Restricted gene flow was found at 30–40 m depth between the two Eunicella morphotypes. Conversely, no genetic structuring has been found among shallow water populations within a spatial scale of ten kilometers. The break in gene flow between shallow and deep populations contributes to explain the morphological variability observed at different depths. Moreover, the limited vertical connectivity hinted that the refugia hypothesis does not apply to E. singularis. Re-colonization of shallow water populations, occasionally affected by mass mortality events, should then be mainly fueled by larvae from other shallow water populations. PMID:27490900

  9. Sequential evolution of cortical activity and effective connectivity of swallowing using fMRI.

    Science.gov (United States)

    Mihai, Paul Glad; Otto, Mareile; Platz, Thomas; Eickhoff, Simon B; Lotze, Martin

    2014-12-01

    Swallowing consists of a hierarchical sequence of primary motor and somatosensory processes. The temporal interplay of different phases is complex and clinical disturbances frequent. Of interest was the temporal interaction of the swallowing network. Time resolution optimized functional magnetic resonance imaging was used to describe the temporal sequence of representation sites of swallowing and their functional connectivity. Sixteen young healthy volunteers were investigated who swallowed 2 ml of water 20 times per run with a repetition time for functional imaging of 514 ms. After applying the general linear model approach to identify activation magnitude in preselected regions of interest repeated measures analysis of variance (rmANOVA) was used to detect relevant effects on lateralization, time, and onset. Furthermore, dynamic causal modeling (DCM) was applied to uncover where the input enters the model and the way in which the cortical regions are connected. The temporal analysis revealed a successive activation starting at the premotor cortex, supplementary motor area (SMA), and bilateral thalamus, followed by the primary sensorimotor cortex, the posterior insula, and cerebellum and culminating with activation in the pons shortly before subsiding. The rmANOVA revealed that activation was lateralized initially to the left hemisphere and gradually moved to the right hemisphere over time. The group random effects DCM analysis resulted in a most likely model that consisted of inputs to SMA and M1S1, bidirectionally connected, and a one-way connection from M1S1 to the posterior insula.

  10. Resting state BOLD functional connectivity at 3T: spin echo versus gradient echo EPI.

    Directory of Open Access Journals (Sweden)

    Piero Chiacchiaretta

    Full Text Available Previous evidence showed that, due to refocusing of static dephasing effects around large vessels, spin-echo (SE BOLD signals offer an increased linearity and promptness with respect to gradient-echo (GE acquisition, even at low field. These characteristics suggest that, despite the reduced sensitivity, SE fMRI might also provide a potential benefit when investigating spontaneous fluctuations of brain activity. However, there are no reports on the application of spin-echo fMRI for connectivity studies at low field. In this study we compared resting state functional connectivity as measured with GE and SE EPI sequences at 3T. Main results showed that, within subject, the GE sensitivity is overall larger with respect to that of SE, but to a less extent than previously reported for activation studies. Noteworthy, the reduced sensitivity of SE was counterbalanced by a reduced inter-subject variability, resulting in comparable group statistical connectivity maps for the two sequences. Furthermore, the SE method performed better in the ventral portion of the default mode network, a region affected by signal dropout in standard GE acquisition. Future studies should clarify if these features of the SE BOLD signal can be beneficial to distinguish subtle variations of functional connectivity across different populations and/or treatments when vascular confounds or regions affected by signal dropout can be a critical issue.

  11. ARC Code TI: sequenceMiner

    Data.gov (United States)

    National Aeronautics and Space Administration — The sequenceMiner was developed to address the problem of detecting and describing anomalies in large sets of high-dimensional symbol sequences. sequenceMiner works...

  12. Mitochondrial DNA sequence variation in the Anatolian Peninsula (Turkey)

    Indian Academy of Sciences (India)

    Hatice Mergen; Reyhan Öner; Cihan Öner

    2004-04-01

    Throughout human history, the region known today as the Anatolian peninsula (Turkey) has served as a junction connecting the Middle East, Europe and Central Asia, and, thus, has been subject to major population movements. The present study is undertaken to obtain information about the distribution of the existing mitochondrial D-loop sequence variations in the Turkish population of Anatolia. A few studies have previously reported mtDNA sequences in Turks. We attempted to extend these results by analysing a cohort that is not only larger, but also more representative of the Turkish population living in Anatolia. In order to obtain a descriptive picture for the phylogenetic distribution of the mitochondrial genome within Turkey, we analysed mitochondrial D-loop region sequence variations in 75 individuals from different parts of Anatolia by direct sequencing. Analysis of the two hypervariable segments within the noncoding region of the mitochondrial genome revealed the existence of 81 nucleotide mutations at 79 sites. The neighbour-joining tree of Kimura’s distance matrix has revealed the presence of six main clusters, of which H and U are the most common. The data obtained are also compared with several European and Turkic Central Asian populations.

  13. Dynamic encoding of natural luminance sequences by LGN bursts.

    Directory of Open Access Journals (Sweden)

    Nicholas A Lesica

    2006-07-01

    Full Text Available In the lateral geniculate nucleus (LGN of the thalamus, visual stimulation produces two distinct types of responses known as tonic and burst. Due to the dynamics of the T-type Ca(2+ channels involved in burst generation, the type of response evoked by a particular stimulus depends on the resting membrane potential, which is controlled by a network of modulatory connections from other brain areas. In this study, we use simulated responses to natural scene movies to describe how modulatory and stimulus-driven changes in LGN membrane potential interact to determine the luminance sequences that trigger burst responses. We find that at low resting potentials, when the T channels are de-inactivated and bursts are relatively frequent, an excitatory stimulus transient alone is sufficient to evoke a burst. However, to evoke a burst at high resting potentials, when the T channels are inactivated and bursts are relatively rare, prolonged inhibitory stimulation followed by an excitatory transient is required. We also observe evidence of these effects in vivo, where analysis of experimental recordings demonstrates that the luminance sequences that trigger bursts can vary dramatically with the overall burst percentage of the response. To characterize the functional consequences of the effects of resting potential on burst generation, we simulate LGN responses to different luminance sequences at a range of resting potentials with and without a mechanism for generating bursts. Using analysis based on signal detection theory, we show that bursts enhance detection of specific luminance sequences, ranging from the onset of excitatory sequences at low resting potentials to the offset of inhibitory sequences at high resting potentials. These results suggest a dynamic role for burst responses during visual processing that may change according to behavioral state.

  14. PROCESS OF ELECTRICAL CONNECTION OF PHOTOVOLTAIC DEVICES

    DEFF Research Database (Denmark)

    2012-01-01

    A photovoltaic cell module comprising at least two serially connected photovoltaic cells on a common substrate, wherein the cells each comprise a first electrode layer, a first charge selective layer, a light harvesting layer which comprises an organic conjugated polymer, and a second charge...... of the pair, which connection is made through the light harvesting layer common to the at least one pair of cells, without forming an electrical connection with the first electrode of the first cell or the second charge selective layer of the second cell; and a method of making such a photovoltaic cell module....... selective layer that selects for an opposite charge to the first charge selective layer, wherein the first electrode layers for each cell are formed such that the first electrode layer of one cell has no direct electrical connection to the first electrode layer of any other cell, and the second charge...

  15. Heteroclinic connections in plane Couette flow

    CERN Document Server

    Halcrow, Jonathan; Cvitanović, Predrag; Viswanath, Divakar

    2008-01-01

    Plane Couette flow transitions to turbulence for Re~325 even though the laminar solution with a linear profile is linearly stable for all Re (Reynolds number). One starting point for understanding this subcritical transition is the existence of invariant sets in the state space of the Navier Stokes equation, such as upper and lower branch equilibria and periodic and relative periodic solutions, that are quite distinct from the laminar solution. This article reports several heteroclinic connections between such objects and briefly describes a numerical method for locating heteroclinic connections. Computing such connections is essential for understanding the global dynamics of spatially localized structures that occur in transitional plane Couette flow. We show that the nature of streaks and streamwise rolls can change significantly along a heteroclinic connection.

  16. 47 CFR 54.506 - Internal connections.

    Science.gov (United States)

    2010-10-01

    ... library receives internal connections services other than basic maintenance services that are shared with other schools or libraries (for example, as part of a consortium), the shared services will be... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED)...

  17. Affine connection form of Regge calculus

    CERN Document Server

    Khatsymovsky, V M

    2015-01-01

    Regge action is represented analogously to how the Palatini action for general relativity (GR) as some functional of the metric and a general connection as independent variables represents the Einstein-Hilbert action. The piecewise flat (or simplicial) spacetime of Regge calculus is equipped with some world coordinates and some piecewise affine metric which is completely defined by the set of edge lengths and the world coordinates of the vertices. The conjugate variables are the general nondegenerate matrices on the 3-simplices which play a role of a general discrete connection. Our previous result on some representation of the Regge calculus action in terms of the local Euclidean (Minkowsky) frame vectors and orthogonal connection matrices as independent variables is somewhat modified for the considered case of the general linear group GL(4,R) of the connection matrices. As a result, we have some action invariant w. r. t. arbitrary change of coordinates of the vertices (and related GL(4,R) transformations in...

  18. Partial connectivity increases cultural accumulation within groups.

    Science.gov (United States)

    Derex, Maxime; Boyd, Robert

    2016-03-15

    Complex technologies used in most human societies are beyond the inventive capacities of individuals. Instead, they result from a cumulative process in which innovations are gradually added to existing cultural traits across many generations. Recent work suggests that a population's ability to develop complex technologies is positively affected by its size and connectedness. Here, we present a simple computer-based experiment that compares the accumulation of innovations by fully and partially connected groups of the same size in a complex fitness landscape. We find that the propensity to learn from successful individuals drastically reduces cultural diversity within fully connected groups. In comparison, partially connected groups produce more diverse solutions, and this diversity allows them to develop complex solutions that are never produced in fully connected groups. These results suggest that explanations of ancestral patterns of cultural complexity may need to consider levels of population fragmentation and interaction patterns between partially isolated groups. PMID:26929364

  19. An Investigation into Node Strength Connectivity Correlation

    Institute of Scientific and Technical Information of China (English)

    SHI Jian-Jun; WANG Yong-Li; HE Da-Ren

    2009-01-01

    We propose investigating the node strength connectivity correlation by a resource-allocation method and the traditional multiple edge method, respectively. A rough analysis suggests that the resource-allocation node strength connectivity correlation is always negative, which is different from the connectivity correlation of the traditional multiple edge node strength (it can show either positive, negative or no correlation). As examples,empirical investigation results for two real world cooperation-competition networks (the 2004 Athens Olympic Games network and the mixed drink network) are presented. We believe that the resource-allocation node strength connectivity correlation can serve as a description of the relative crackajack distribution, which is a complementarity of the traditional multiple edge one.

  20. Bound on m-restricted Edge Connectivity

    Institute of Scientific and Technical Information of China (English)

    Jian-ping Ou; Fu-ji Zhang

    2003-01-01

    An m-restricted edge cut is an edge cut that separates a connected graph into a disconnected one with no components having order less than m. m-restricted edge connectivity λm is the cardinality of a minimum m-restricted edge cut. Let G be a connected k-regular graph of order at least 2m that contains m-restricted edge cuts and X be a subgraph of G. Let( )(X) denote the number of edges with one end in X and the other not in X and ξm = min{( )(X): X is a connected vertex-induced subgraph of order m}. It is proved in this paper that if G has girth at least m/2 + 2, then λm ≤ξm. The upper bound of λm is sharp.

  1. Application of Partially Connected Neural Network

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    This paper focuses mainly on application of Partially Connected Backpropagation Neural Network (PCBP) instead of typical Fully Connected Neural Network (FCBP). The initial neural network is fully connected, after training with sample data using cross-entropy as error function, a clustering method is employed to cluster weights between inputs to hidden layer and from hidden to output layer, and connections that are relatively unnecessary are deleted, thus the initial network becomes a PCBP network.Then PCBP can be used in prediction or data mining by training PCBP with data that comes from database. At the end of this paper, several experiments are conducted to illustrate the effects of PCBP using Iris data set.

  2. Connecting and communicating after Typhoon Haiyan

    Directory of Open Access Journals (Sweden)

    Mariko Hall

    2014-02-01

    Full Text Available In the first month of the Typhoon Haiyan response, one of the priorities facing the international community was to re-establish internet connectivity in order to facilitate information sharing and the provision of assistance.

  3. MedlinePlus Connect: Technical Information

    Science.gov (United States)

    ... code can be submitted per request. Supports the HL7 Context-Aware Knowledge Retrieval (Infobutton) standard. Connects using ... How does it work? Responds to requests with XML, JSON, or JSONP, which implementers can use to ...

  4. Periodic words connected with the Fibonacci words

    Directory of Open Access Journals (Sweden)

    G. M. Barabash

    2016-06-01

    Full Text Available In this paper we introduce two families of periodic words (FLP-words of type 1 and FLP-words of type 2 that are connected with the Fibonacci words and investigated their properties.

  5. Comparing brains by matching connectivity profiles.

    Science.gov (United States)

    Mars, Rogier B; Verhagen, Lennart; Gladwin, Thomas E; Neubert, Franz-Xaver; Sallet, Jerome; Rushworth, Matthew F S

    2016-01-01

    The great promise of comparative neuroscience is to understand why brains differ by investigating the relations between variations in the organization of different brains, their evolutionary history, and their current ecological niche. For this approach to be successful, the organization of different brains needs to be quantifiable. Here, we present an approach to formally comparing the connectivity of different cortical areas across different brains. We exploit the fact that cortical regions can be characterized by the unique pattern of connectivity, the so-called connectivity fingerprint. By comparing connectivity fingerprints between cortical areas in the human and non-human primate brain we can identify between-species homologs, but also illustrate that is driving differences between species. We illustrate the approach by comparing the organization of the frontal cortex between humans and macaques, showing general similarities combined with some differences in the lateral frontal pole.

  6. Sequencing Needs for Viral Diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Gardner, S N; Lam, M; Mulakken, N J; Torres, C L; Smith, J R; Slezak, T

    2004-01-26

    We built a system to guide decisions regarding the amount of genomic sequencing required to develop diagnostic DNA signatures, which are short sequences that are sufficient to uniquely identify a viral species. We used our existing DNA diagnostic signature prediction pipeline, which selects regions of a target species genome that are conserved among strains of the target (for reliability, to prevent false negatives) and unique relative to other species (for specificity, to avoid false positives). We performed simulations, based on existing sequence data, to assess the number of genome sequences of a target species and of close phylogenetic relatives (''near neighbors'') that are required to predict diagnostic signature regions that are conserved among strains of the target species and unique relative to other bacterial and viral species. For DNA viruses such as variola (smallpox), three target genomes provide sufficient guidance for selecting species-wide signatures. Three near neighbor genomes are critical for species specificity. In contrast, most RNA viruses require four target genomes and no near neighbor genomes, since lack of conservation among strains is more limiting than uniqueness. SARS and Ebola Zaire are exceptional, as additional target genomes currently do not improve predictions, but near neighbor sequences are urgently needed. Our results also indicate that double stranded DNA viruses are more conserved among strains than are RNA viruses, since in most cases there was at least one conserved signature candidate for the DNA viruses and zero conserved signature candidates for the RNA viruses.

  7. Better models are more effectively connected models

    Science.gov (United States)

    Nunes, João Pedro; Bielders, Charles; Darboux, Frederic; Fiener, Peter; Finger, David; Turnbull-Lloyd, Laura; Wainwright, John

    2016-04-01

    The concept of hydrologic and geomorphologic connectivity describes the processes and pathways which link sources (e.g. rainfall, snow and ice melt, springs, eroded areas and barren lands) to accumulation areas (e.g. foot slopes, streams, aquifers, reservoirs), and the spatial variations thereof. There are many examples of hydrological and sediment connectivity on a watershed scale; in consequence, a process-based understanding of connectivity is crucial to help managers understand their systems and adopt adequate measures for flood prevention, pollution mitigation and soil protection, among others. Modelling is often used as a tool to understand and predict fluxes within a catchment by complementing observations with model results. Catchment models should therefore be able to reproduce the linkages, and thus the connectivity of water and sediment fluxes within the systems under simulation. In modelling, a high level of spatial and temporal detail is desirable to ensure taking into account a maximum number of components, which then enables connectivity to emerge from the simulated structures and functions. However, computational constraints and, in many cases, lack of data prevent the representation of all relevant processes and spatial/temporal variability in most models. In most cases, therefore, the level of detail selected for modelling is too coarse to represent the system in a way in which connectivity can emerge; a problem which can be circumvented by representing fine-scale structures and processes within coarser scale models using a variety of approaches. This poster focuses on the results of ongoing discussions on modelling connectivity held during several workshops within COST Action Connecteur. It assesses the current state of the art of incorporating the concept of connectivity in hydrological and sediment models, as well as the attitudes of modellers towards this issue. The discussion will focus on the different approaches through which connectivity

  8. The spin connection of twisted geometry

    OpenAIRE

    Haggard, Hal M.; Rovelli, Carlo; Vidotto, Francesca; Wieland, Wolfgang

    2012-01-01

    Twisted geometry is a piecewise-flat geometry less rigid than Regge geometry. In Loop Gravity, it provides the classical limit for each step of the truncation utilized in the definition of the quantum theory. We define the torsionless spin-connection of a twisted geometry. The difficulty given by the discontinuity of the triad is addressed by interpolating between triads. The curvature of the resulting spin connection reduces to the Regge curvature in the case of a Regge geometry.

  9. Regulation of synaptic connectivity by glia

    OpenAIRE

    Eroglu, Cagla; Barres, Ben A

    2010-01-01

    The human brain contains more than 100 trillion (1014) synaptic connections, which form all of its neural circuits. Neuroscientists have long been interested in how this complex synaptic web is weaved during development and remodelled during learning and disease. Recent studies have uncovered that glial cells are important regulators of synaptic connectivity. These cells are far more active than was previously thought and are powerful controllers of synapse formation, function, plasticity and...

  10. Univalent Biharmonic Mappings and Linearly Connected Domains

    Directory of Open Access Journals (Sweden)

    Zayid Abdulhadi

    2015-11-01

    Full Text Available A four times continuously differentiable complex valued function F = u + iv in a simply connected domain Ω is biharmonic if the laplacian of F is harmonic. Every biharmonic mapping F in Ω has the representation F = |z|^2 G + K, where G and K are harmonic in Ω. This paper investigates the relationship between the univalence of F and of K using the concept of linearly connected domains.

  11. Computational Unification: a Vision for Connecting Researchers

    OpenAIRE

    Troy III, Richard M.

    2004-01-01

    The extent to which the benefits of science can be fully realized depends critically upon the quality of the connection between researchers themselves and between researchers and members of the public. We believe that it is now possible to improve these connections on a community-wide and even world-wide basis through the use of an appropriate information management system. In this paper we explore the concepts and challenges, and propose an architecture for the implementation of such a syste...

  12. SERVIR Town Hall - Connecting Space to Village

    Science.gov (United States)

    Limaye, Ashutosh S.; Searby, Nancy D.; Irwin, Daniel; Albers, Cerese

    2013-01-01

    SERVIR, a joint NASA-USAID project, strives to improve environmental decision making through the use of Earth observations, models, and geospatial technology innovations. SERVIR connects these assets with the needs of end users in Mesoamerica, East Africa, and Hindu Kush-Himalaya regions. This Town Hall meeting will engage the AGU community by exploring examples of connecting Space to Village with SERVIR science applications.

  13. Autaptic Connections Shift Network Excitability and Bursting

    OpenAIRE

    Wiles, Laura; Gu, Shi; Pasqualetti, Fabio; Bassett, Danielle S.; Meaney, David F.

    2016-01-01

    Network architecture forms a critical constraint on neuronal function. Here we examine the role of structural autapses, when a neuron synapses onto itself, in driving network-wide bursting behavior. Using a simple spiking model of neuronal activity, we study how autaptic connections affect activity patterns, and evaluate if neuronal degree or controllability are significant factors that affect changes in bursting from these autaptic connections. We observed that adding increasing numbers of a...

  14. Zone heated diesel particulate filter electrical connection

    Science.gov (United States)

    Gonze, Eugene V.; Paratore, Jr., Michael J.

    2010-03-30

    An electrical connection system for a particulate filter is provided. The system includes: a particulate filter (PF) disposed within an outer shell wherein the PF is segmented into a plurality of heating zones; an outer mat disposed between the particulate filter and the outer shell; an electrical connector coupled to the outer shell of the PF; and a plurality of printed circuit connections that extend along the outer surface of the PF from the electrical connector to the plurality of heating zones.

  15. Adiabatic Connection for Strictly-Correlated Electrons

    OpenAIRE

    Liu, Zhenfei; Burke, Kieron

    2009-01-01

    Modern density functional theory (DFT) calculations employ the Kohn-Sham (KS) system of non-interacting electrons as a reference, with all complications buried in the exchange-correlation energy (Exc). The adiabatic connection formula gives an exact expression for Exc. We consider DFT calculations that instead employ a reference of strictly-correlated electrons. We define a "decorrelation energy" that relates this reference to the real system, and derive the corresponding adiabatic connection...

  16. Sequence Patterns of Identity Authentication Protocols

    Institute of Scientific and Technical Information of China (English)

    Tao Hongcai; He Dake

    2006-01-01

    From the viewpoint of protocol sequence, analyses are made of the sequence patterns of possible identity authentication protocol under two cases: with or without the trusted third party (TTP). Ten feasible sequence patterns of authentication protocol with TTP and 5 sequence patterns without TTP are gained. These gained sequence patterns meet the requirements for identity authentication,and basically cover almost all the authentication protocols with TTP and without TTP at present. All of the sequence patterns gained are classified into unilateral or bilateral authentication. Then , according to the sequence symmetry, several good sequence patterns with TTP are evaluated. The accompolished results can provide a reference to design of new identity authentication protocols.

  17. Admissibility, stable units and connected components

    CERN Document Server

    Xarez, J J

    2011-01-01

    Consider a reflection from a finitely-complete category $\\mathbb{C}$ into its full subcategory $\\mathbb{M}$, with unit $\\eta :1_\\mathbb{C}\\rightarrow HI$. Suppose there is a left-exact functor $U$ into the category of sets, such that $UH$ reflects isomorphisms and $U(\\eta_C)$ is a surjection, for every $C\\in\\mathbb{C}$. If, in addition, all the maps $\\mathbb{M}(T,M)\\rightarrow \\mathbf{Set}(1,U(M))$ induced by the functor $UH$ are surjections, where $T$ and 1 are respectively terminal objects in $\\mathbb{C}$ and $\\mathbf{Set}$, for every object $M$ in the full subcategory $\\mathbb{M}$, then it is true that: the reflection $H\\vdash I$ is semi-left-exact (admissible in the sense of categorical Galois theory) if and only if its connected components are "connected"; it has stable units if and only if any finite product of connected components is "connected". Where the meaning of "connected" is the usual in categorical Galois theory, and the definition of connected component with respect to the ground structure wil...

  18. Service connectivity architecture for mobile augmented reality

    Science.gov (United States)

    Turunen, Tuukka; Pyssysalo, Tino; Roening, Juha

    2001-06-01

    Mobile augmented reality can be utilized in a number of different services, and it provides a lot of added value compared to the interfaces used in mobile multimedia today. Intelligent service connectivity architecture is needed for the emerging commercial mobile augmented reality services, to guarantee mobility and interoperability on a global scale. Some of the key responsibilities of this architecture are to find suitable service providers, to manage the connection with and utilization of such providers, and to allow smooth switching between them whenever the user moves out of the service area of the service provider she is currently connected to. We have studied the potential support technologies for such architectures and propose a way to create an intelligent service connectivity architecture based on current and upcoming wireless networks, an Internet backbone, and mechanisms to manage service connectivity in the upper layers of the protocol stack. In this paper, we explain the key issues of service connectivity, describe the properties of our architecture, and analyze the functionality of an example system. Based on these, we consider our proposition a good solution to the quest for global interoperability in mobile augmented reality services.

  19. Wireless device connection problems and design solutions

    Science.gov (United States)

    Song, Ji-Won; Norman, Donald; Nam, Tek-Jin; Qin, Shengfeng

    2016-09-01

    Users, especially the non-expert users, commonly experience problems when connecting multiple devices with interoperability. While studies on multiple device connections are mostly concentrated on spontaneous device association techniques with a focus on security aspects, the research on user interaction for device connection is still limited. More research into understanding people is needed for designers to devise usable techniques. This research applies the Research-through-Design method and studies the non-expert users' interactions in establishing wireless connections between devices. The "Learning from Examples" concept is adopted to develop a study focus line by learning from the expert users' interaction with devices. This focus line is then used for guiding researchers to explore the non-expert users' difficulties at each stage of the focus line. Finally, the Research-through-Design approach is used to understand the users' difficulties, gain insights to design problems and suggest usable solutions. When connecting a device, the user is required to manage not only the device's functionality but also the interaction between devices. Based on learning from failures, an important insight is found that the existing design approach to improve single-device interaction issues, such as improvements to graphical user interfaces or computer guidance, cannot help users to handle problems between multiple devices. This study finally proposes a desirable user-device interaction in which images of two devices function together with a system image to provide the user with feedback on the status of the connection, which allows them to infer any required actions.

  20. Holistic Connectivity Controller for Multirobot Dispersion

    Directory of Open Access Journals (Sweden)

    Zhenqiang Mi

    2013-01-01

    Full Text Available Dispersion of mobile robots in a certain formation is prerequisite in many applications; one of the most important issues during the entire process is to maintain the interagent connections, as well as to restore them whenever they were broken. We investigate the aforementioned problem in this work by designing a holistic connectivity controller (HCC to regulate and restore the interagent connections during the dispersion of the mobile network. HCC consists of two core structures. Firstly, to illustrate the multirobot dispersion, we adopt the distributed link removal algorithm (DLRA, which is able to remove redundant links in the multirobot network to facilitate the dispersion and only requires local information of no more than two-hop neighbors. Secondly, the proposed approach is extended to the problem of connectivity restoration with consideration of simultaneous failure of multiple agents. A connectivity restoration strategy is proposed, and then the recoverability of network connectivity is investigated. The proposed HCC has also integrated motion controller to regulate the movement of the mobile robots, so that interrobot collisions can be effectively avoided. Theoretical analysis and computer simulations have confirmed the efficiency and scalability of the proposed schemes.

  1. Transgressive Surface as Sequence Boundary

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Analysis of the four cases of the sequence boundary (SB)-transgressive surface (TS) relation in nature shows that applying transgressive surfaces as sequence boundaries has the following merits: it improves the methodology of stratigraphic subdivision; the position of transgressive surface in a sea level curve is relatively fixed; the transgressive surface is a transforming surface of the stratal structure; in platforms or ramps, the transgressive surface is the only choice for determining the sequence boundary; the transgressive surface is a readily recognized physical surface reflected by seismic records in seismostratigraphy. The paper reaches a conclusion that to delineate a SB in terms of the TS is theoretically and practically better than to delineate it between highstand and lowstand sediments as has been done traditionally.

  2. On the base sequence conjecture

    CERN Document Server

    Djokovic, Dragomir Z

    2010-01-01

    Let BS(m,n) denote the set of base sequences (A;B;C;D), with A and B of length m and C and D of length n. The base sequence conjecture (BSC) asserts that BS(n+1,n) exist (i.e., are non-empty) for all n. This is known to be true for n <= 36 and when n is a Golay number. We show that it is also true for n=37 and n=38. It is worth pointing out that BSC is stronger than the famous Hadamard matrix conjecture. In order to demonstrate the abundance of base sequences, we have previously attached to BS(n+1,n) a graph Gamma_n and computed the Gamma_n for n <= 27. We now extend these computations and determine the Gamma_n for n=28,...,35. We also propose a conjecture describing these graphs in general.

  3. Vector sequences - Budding yeast cDNA sequencing project | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available Budding yeast cDNA sequencing project Vector sequences Data detail Data name Vector sequences Description of data contents Vector seq...wnload License Update History of This Database Site Policy | Contact Us Vector sequences - Budding yeast cDNA sequencing project | LSDB Archive ... ...uences used for sequencing. Multi FASTA format. 7 entries. Data file File name: vec

  4. KERNEL WORDS AND GAP SEQUENCE OF THE TRIBONACCI SEQUENCE

    Institute of Scientific and Technical Information of China (English)

    Yuke HUANG; Zhiying WEN

    2016-01-01

    In this paper, we investigate the factor properties and gap sequence of the Tri-bonacci sequence, the fixed point of the substitution σ(a, b, c) = (ab, ac, a). Let ωp be the p-th occurrence of ω and Gp(ω) be the gap between ωp and ωp+1. We introduce a notion of kernel for each factor ω, and then give the decomposition of the factor ω with respect to its kernel. Using the kernel and the decomposition, we prove the main result of this paper:for each factorω, the gap sequence{Gp(ω)}p≥1 is the Tribonacci sequence over the alphabet{G1(ω), G2(ω), G4(ω)}, and the expressions of gaps are determined completely. As an appli-cation, for each factorω and p∈N, we determine the position ofωp. Finally we introduce a notion of spectrum for studying some typical combinatorial properties, such as power, overlap and separate of factors.

  5. A repetitive sequence assembler based on next-generation sequencing.

    Science.gov (United States)

    Lian, S; Tu, Y; Wang, Y; Chen, X; Wang, L

    2016-01-01

    Repetitive sequences of variable length are common in almost all eukaryotic genomes, and most of them are presumed to have important biomedical functions and can cause genomic instability. Next-generation sequencing (NGS) technologies provide the possibility of identifying capturing these repetitive sequences directly from the NGS data. In this study, we assessed the performances in identifying capturing repeats of leading assemblers, such as Velvet, SOAPdenovo, SGA, MSR-CA, Bambus2, ALLPATHS-LG, and AByss using three real NGS datasets. Our results indicated that most of them performed poorly in capturing the repeats. Consequently, we proposed a repetitive sequence assembler, named NGSReper, for capturing repeats from NGS data. Simulated datasets were used to validate the feasibility of NGSReper. The results indicate that the completeness of capturing repeat is up to 99%. Cross validation was performed in three real NGS datasets, and extensive comparisons indicate that NGSReper performed best in terms of completeness and accuracy in capturing repeats. In conclusion, NGSReper is an appropriate and suitable tool for capturing repeats directly from NGS data. PMID:27525861

  6. Sequences and series involving the sequence of composite numbers

    Directory of Open Access Journals (Sweden)

    Panayiotis Vlamos

    2002-01-01

    Full Text Available Denoting by pn and cn the nth prime number and the nth composite number, respectively, we prove that both the sequence (xnn≥1, defined by xn=∑k=1n (ck+1−ck / k−pn / n, and the series ∑n=1∞ (pcn−cpn / npn are convergent.

  7. Integrated sequence analysis. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, K.; Pyy, P

    1998-02-01

    The NKS/RAK subprojet 3 `integrated sequence analysis` (ISA) was formulated with the overall objective to develop and to test integrated methodologies in order to evaluate event sequences with significant human action contribution. The term `methodology` denotes not only technical tools but also methods for integration of different scientific disciplines. In this report, we first discuss the background of ISA and the surveys made to map methods in different application fields, such as man machine system simulation software, human reliability analysis (HRA) and expert judgement. Specific event sequences were, after the surveys, selected for application and testing of a number of ISA methods. The event sequences discussed in the report were cold overpressure of BWR, shutdown LOCA of BWR, steam generator tube rupture of a PWR and BWR disturbed signal view in the control room after an external event. Different teams analysed these sequences by using different ISA and HRA methods. Two kinds of results were obtained from the ISA project: sequence specific and more general findings. The sequence specific results are discussed together with each sequence description. The general lessons are discussed under a separate chapter by using comparisons of different case studies. These lessons include areas ranging from plant safety management (design, procedures, instrumentation, operations, maintenance and safety practices) to methodological findings (ISA methodology, PSA,HRA, physical analyses, behavioural analyses and uncertainty assessment). Finally follows a discussion about the project and conclusions are presented. An interdisciplinary study of complex phenomena is a natural way to produce valuable and innovative results. This project came up with structured ways to perform ISA and managed to apply the in practice. The project also highlighted some areas where more work is needed. In the HRA work, development is required for the use of simulators and expert judgement as

  8. $delta$-Quasi Cauchy Sequences

    OpenAIRE

    Cakalli, Huseyin

    2010-01-01

    Recently, a concept of forward continuity and a concept of forward compactness are introduced in the senses that a function $f$ is forward continuous if $\\lim_{n\\to\\infty} \\Delta f(x_{n})=0$ whenever $\\lim_{n\\to\\infty} \\Delta x_{n}=0$,\\; and a subset $E$ of $\\textbf{R}$ is forward compact if any sequence $\\textbf{x}=(x_{n})$ of points in $E$ has a subsequence $\\textbf{z}=(z_{k})=(x_{n_{k}})$ of the sequence $\\textbf{x}$ such that $\\lim_{k\\to \\infty} \\Delta z_{k}=0$ where $\\Delta z_{k}=z_{k+1}...

  9. P-connection on Riemannian almost product manifolds

    CERN Document Server

    Mekerov, Dimitar

    2009-01-01

    In the present work, we introduce a linear connection (preserving the almost product structure and the Riemannian metric) on Riemannian almost product manifolds. This connection, called P-connection, is an analogue of the first canonical connection of Lichnerowicz in the Hermitian geometry and the B-connection in the geometry of the almost complex manifolds with Norden metric. Particularly, we consider the P-connection on a the class of manifolds with nonintegrable almost product structure.

  10. The origin of biased sequence depth in sequence-independent nucleic acid amplification and optimization for efficient massive parallel sequencing.

    Directory of Open Access Journals (Sweden)

    Toon Rosseel

    Full Text Available Sequence Independent Single Primer Amplification is one of the most widely used random amplification approaches in virology for sequencing template preparation. This technique relies on oligonucleotides consisting of a 3' random part used to prime complementary DNA synthesis and a 5' defined tag sequence for subsequent amplification. Recently, this amplification method was combined with next generation sequencing to obtain viral sequences. However, these studies showed a biased distribution of the resulting sequence reads over the analyzed genomes. The aim of this study was to elucidate the mechanisms that lead to biased sequence depth when using random amplification. Avian paramyxovirus type 8 was used as a model RNA virus to investigate these mechanisms. We showed, based on in silico analysis of the sequence depth in relation to GC-content, predicted RNA secondary structure and sequence complementarity to the 3' part of the tag sequence, that the tag sequence has the main contribution to the observed bias in sequence depth. We confirmed this finding experimentally using both fragmented and non-fragmented viral RNAs as well as primers differing in random oligomer length (6 or 12 nucleotides and in the sequence of the amplification tag. The observed oligonucleotide annealing bias can be reduced by extending the random oligomer sequence and by in silico combining sequence data from SISPA experiments using different 5' defined tag sequences. These findings contribute to the optimization of random nucleic acid amplification protocols that are currently required for downstream applications such as viral metagenomics and microarray analysis.

  11. Mutual connectivity analysis (MCA) using generalized radial basis function neural networks for nonlinear functional connectivity network recovery in resting-state functional MRI

    Science.gov (United States)

    D'Souza, Adora M.; Abidin, Anas Zainul; Nagarajan, Mahesh B.; Wismüller, Axel

    2016-03-01

    We investigate the applicability of a computational framework, called mutual connectivity analysis (MCA), for directed functional connectivity analysis in both synthetic and resting-state functional MRI data. This framework comprises of first evaluating non-linear cross-predictability between every pair of time series prior to recovering the underlying network structure using community detection algorithms. We obtain the non-linear cross-prediction score between time series using Generalized Radial Basis Functions (GRBF) neural networks. These cross-prediction scores characterize the underlying functionally connected networks within the resting brain, which can be extracted using non-metric clustering approaches, such as the Louvain method. We first test our approach on synthetic models with known directional influence and network structure. Our method is able to capture the directional relationships between time series (with an area under the ROC curve = 0.92 +/- 0.037) as well as the underlying network structure (Rand index = 0.87 +/- 0.063) with high accuracy. Furthermore, we test this method for network recovery on resting-state fMRI data, where results are compared to the motor cortex network recovered from a motor stimulation sequence, resulting in a strong agreement between the two (Dice coefficient = 0.45). We conclude that our MCA approach is effective in analyzing non-linear directed functional connectivity and in revealing underlying functional network structure in complex systems.

  12. Connectivity measures in EEG microstructural sleep elements

    Directory of Open Access Journals (Sweden)

    Dimitris eSakellariou

    2016-02-01

    Full Text Available During Non-Rapid Eye Movement sleep (NREM the brain is relatively disconnected from the environment, while connectedness between brain areas is also decreased. Evidence indicates that these dynamic connectivity changes are delivered by microstructural elements of sleep: short periods of environmental stimuli evaluation followed by sleep promoting procedures. The connectivity patterns of the latter, among other aspects of sleep microstructure, are still to be fully elucidated.We suggest here a methodology for the assessment and investigation of the connectivity patterns of EEG microstructural elements, such as sleep spindles. The methodology combines techniques in the preprocessing, estimation, error assessing and visualization of results levels in order to allow the detailed examination of the connectivity aspects (levels and directionality of information flow over frequency and time with notable resolution, while dealing with the volume conduction and EEG reference assessment. The high temporal and frequency resolution of the methodology will allow the association between the microelements and the dynamically forming networks that characterise them, and consequently possibly reveal aspects of the EEG microstructure. The proposed methodology is initially tested on artificially generated signals for proof of concept and subsequently applied to real EEG recordings via a custom built MATLAB-based tool developed for such studies. Preliminary results from 843 fast sleep spindles recorded in whole night sleep of 5 healthy volunteers indicate a prevailing pattern of interactions between centroparietal and frontal regions.We demonstrate hereby an opening to our knowledge attempt to estimate the scalp EEG connectivity that characterizes fast sleep spindles via an EEG-element connectivity methodology we propose. The application of the latter, via a computational tool we developed suggests it is able to investigate the connectivity patterns related to the

  13. Increased facilitatory connectivity from the pre-SMA to the left dorsal premotor cortex during pseudoword repetition

    DEFF Research Database (Denmark)

    Hartwigsen, Gesa; Saur, Dorothee; Price, Cathy J;

    2013-01-01

    modeling to investigate effective connectivity between premotor areas during overt repetition of words and pseudowords presented in both the auditory and visual modalities. Regions involved in phonological aspects of language production were identified as those where regional increases in the BOLD signal...... were common to repetition in both modalities. We thus obtained three seed regions: the bilateral pre-SMA, left dorsal premotor cortex (PMd), and left ventral premotor cortex that were used to test 63 different models of effective connectivity in the premotor network for pseudoword relative to word...... that the pre-SMA plays a supervisory role in the generation and subsequent sequencing of motor plans. Diffusion tensor imaging-based fiber tracking in another group of healthy volunteers showed that the functional connection between both regions is underpinned by a direct cortico-cortical anatomical connection....

  14. Sequences in language and text

    CERN Document Server

    Mikros, George K

    2015-01-01

    The aim of this volume is to present the diverse but highly interesting area of the quantitative analysis of the sequence of various linguistic structures. The collected articles present a wide spectrum of quantitative analyses of linguistic syntagmatic structures and explore novel sequential linguistic entities. This volume will be interesting to all researchers studying linguistics using quantitative methods.

  15. Single-primer fluorescent sequencing

    Energy Technology Data Exchange (ETDEWEB)

    Ruth, J.L.; Morgan, C.A.; Middendorf, L.R.; Grone, D.L.; Brumbaugh, J.A.

    1987-05-01

    Modified linker arm oligonucleotides complementary to standard M13 priming sites were synthesized, labelled with either one, two, or three fluoresceins, and purified by reverse-phase HPLC. When used as primers in standard dideoxy M13 sequencing with /sup 32/P-dNTPs, normal autoradiographic patterns were obtained. To eliminate the radioactivity, direct on-line fluorescence detection was achieved by the use of a scanning 10 mW Argon laser emitting 488 nm light. Fluorescent bands were detected directly in standard 0.2 or 0.35 mm thick polyacrylamide gels at a distance of 24 cm from the loading wells by a photomultiplier tube filtered at 520 nm. Horizontal and temporal location of each band was displayed by computer as a band in real time, providing visual appearance similar to normal 4-lane autoradiograms. Using a single primer labelled with two fluoresceins, sequences of between 500 and 600 bases have been read in a single loading with better than 98% accuracy; up to 400 bases can be read reproducibly with no errors. More than 50 sequences have been determined by this method. This approach requires only 1-2 ug of cloned template, and produces continuous sequence data at about one band per minute.

  16. Single-cell semiconductor sequencing.

    Science.gov (United States)

    Kohn, Andrea B; Moroz, Tatiana P; Barnes, Jeffrey P; Netherton, Mandy; Moroz, Leonid L

    2013-01-01

    RNA-seq or transcriptome analysis of individual cells and small-cell populations is essential for virtually any biomedical field. It is especially critical for developmental, aging, and cancer biology as well as neuroscience where the enormous heterogeneity of cells present a significant methodological and conceptual challenge. Here we present two methods that allow for fast and cost-efficient transcriptome sequencing from ultra-small amounts of tissue or even from individual cells using semiconductor sequencing technology (Ion Torrent, Life Technologies). The first method is a reduced representation sequencing which maximizes capture of RNAs and preserves transcripts' directionality. The second, a template-switch protocol, is designed for small mammalian neurons. Both protocols, from cell/tissue isolation to final sequence data, take up to 4 days. The efficiency of these protocols has been validated with single hippocampal neurons and various invertebrate tissues including individually identified neurons within a simpler memory-forming circuit of Aplysia californica and early (1-, 2-, 4-, 8-cells) embryonic and developmental stages from basal metazoans.

  17. Farey Sequences and Resistor Networks

    Indian Academy of Sciences (India)

    Sameen Ahmed Khan

    2012-05-01

    In this article, we employ the Farey sequence and Fibonacci numbers to establish strict upper and lower bounds for the order of the set of equivalent resistances for a circuit constructed from equal resistors combined in series and in parallel. The method is applicable for networks involving bridge and non-planar circuits.

  18. Instruction Sequences for Computer Science

    NARCIS (Netherlands)

    J.A. Bergstra; C.A. Middelburg

    2012-01-01

    This book demonstrates that the concept of an instruction sequence offers a novel and useful viewpoint on issues relating to diverse subjects in computer science. Selected issues relating to well-known subjects from the theory of computation and the area of computer architecture are rigorously inves

  19. Fractals in DNA sequence analysis

    Institute of Scientific and Technical Information of China (English)

    Yu Zu-Guo(喻祖国); Vo Anh; Gong Zhi-Min(龚志民); Long Shun-Chao(龙顺潮)

    2002-01-01

    Fractal methods have been successfully used to study many problems in physics, mathematics, engineering, finance,and even in biology. There has been an increasing interest in unravelling the mysteries of DNA; for example, how can we distinguish coding and noncoding sequences, and the problems of classification and evolution relationship of organisms are key problems in bioinformatics. Although much research has been carried out by taking into consideration the long-range correlations in DNA sequences, and the global fractal dimension has been used in these works by other people, the models and methods are somewhat rough and the results are not satisfactory. In recent years, our group has introduced a time series model (statistical point of view) and a visual representation (geometrical point of view)to DNA sequence analysis. We have also used fractal dimension, correlation dimension, the Hurst exponent and the dimension spectrum (multifractal analysis) to discuss problems in this field. In this paper, we introduce these fractal models and methods and the results of DNA sequence analysis.

  20. Resting state functional connectivity in anorexia nervosa.

    Science.gov (United States)

    Phillipou, Andrea; Abel, Larry Allen; Castle, David Jonathan; Hughes, Matthew Edward; Nibbs, Richard Grant; Gurvich, Caroline; Rossell, Susan Lee

    2016-05-30

    Anorexia Nervosa (AN) is a serious psychiatric illness characterised by a disturbance in body image, a fear of weight gain and significantly low body weight. The factors involved in the genesis and maintenance of AN are unclear, though the potential neurobiological underpinnings of the condition are of increasing interest. Through the investigation of functional connectivity of the brain at rest, information relating to neuronal communication and integration of information that may relate to behaviours and cognitive symptoms can be explored. The aim of this study was to investigate functional connectivity of the default mode network, and sensorimotor and visual networks in AN. 26 females with AN and 27 healthy control participants matched for age, gender and premorbid intelligence underwent a resting state functional magnetic resonance imaging scan. Default mode network functional connectivity did not differ between groups. AN participants displayed reduced functional connectivity between the sensorimotor and visual networks, in comparison to healthy controls. This finding is discussed in terms of differences in visuospatial processing in AN and the distortion of body image experienced by these individuals. Overall, the findings suggest that sensorimotor and visual network connectivity may be related to visuospatial processing in AN, though, further research is required. PMID:27111812

  1. Connectivity: An emerging concept for physiotherapy practice.

    Science.gov (United States)

    Nicholls, David A; Atkinson, Karen; Bjorbækmo, Wenche S; Gibson, Barbara E; Latchem, Julie; Olesen, Jens; Ralls, Jenny; Setchell, Jennifer

    2016-01-01

    Having spent their first century anchored to a biomedical model of practice, physiotherapists have been increasingly interested in exploring new models and concepts that will better equip them for serving the health-care needs of 21st century clients/patients. Connectivity offers one such model. With an extensive philosophical background in phenomenology, symbolic interactionism, structuralism, and postmodern research, connectivity resists the prevailing western biomedical view that health professionals should aim to increase people's independence and autonomy, preferring instead to identify and amplify opportunities for collaboration and co-dependence. Connectivity critiques the normalization that underpins modern health care, arguing that our constant search for deviance is building stigma and discrimination into our everyday practice. It offers provocative opportunities for physiotherapists to rethink some of the fundamental tenets of their profession and better align physiotherapy with 21st century societal expectations. In this paper, we provide a background to the place connectivity may play in future health care, and most especially future physiotherapy practice. The paper examines some of the philosophical antecedents that have made connectivity an increasingly interesting and challenging concept in health care today. PMID:27050116

  2. Connectivity in finite ad-hoc networks

    Institute of Scientific and Technical Information of China (English)

    WANG HanXing; LU GuiLin; JIA WeiJia; ZHAO Wei

    2008-01-01

    Research on ad-hoc network connectivity has mainly focused on asymptotic results In the number of nodes in the network. For a one-dimensional ad-hoc network G1, assuming all the nodes are Independently uniform distributed in a closed Interval [O, Z](z ∈ R+), we derive a generic formula for the probability that the network is connected. The finite connected ad-hoc networks is analyzed. And we separately suggest necessary conditions to make the ad-hoc network to be connected in one and two dimensional cases, facing possible failed nodes (f-nodes). Based on the necessary condition and unit-disk assumption for the node transmission, we prove that the nodes of the connected two-dimensional ad-hoc networks (G2) can be di-vided into at most five different groups. For an f-node n0 in either of the five groups, we derive a close formula for the probability that there is at least one route between a pair of nodes in G2 - {no}.

  3. Connected Car: Quantified Self becomes Quantified Car

    Directory of Open Access Journals (Sweden)

    Melanie Swan

    2015-02-01

    Full Text Available The automotive industry could be facing a situation of profound change and opportunity in the coming decades. There are a number of influencing factors such as increasing urban and aging populations, self-driving cars, 3D parts printing, energy innovation, and new models of transportation service delivery (Zipcar, Uber. The connected car means that vehicles are now part of the connected world, continuously Internet-connected, generating and transmitting data, which on the one hand can be helpfully integrated into applications, like real-time traffic alerts broadcast to smartwatches, but also raises security and privacy concerns. This paper explores the automotive connected world, and describes five killer QS (Quantified Self-auto sensor applications that link quantified-self sensors (sensors that measure the personal biometrics of individuals like heart rate and automotive sensors (sensors that measure driver and passenger biometrics or quantitative automotive performance metrics like speed and braking activity. The applications are fatigue detection, real-time assistance for parking and accidents, anger management and stress reduction, keyless authentication and digital identity verification, and DIY diagnostics. These kinds of applications help to demonstrate the benefit of connected world data streams in the automotive industry and beyond where, more fundamentally for human progress, the automation of both physical and now cognitive tasks is underway.

  4. k-Connectivity of Random Key Graphs

    CERN Document Server

    Zhao, Jun; Gligor, Virgil

    2015-01-01

    Random key graphs represent topologies of secure wireless sensor networks that apply the seminal Eschenauer-Gligor random key predistribution scheme to secure communication between sensors. These graphs have received much attention and also been used in diverse application areas beyond secure sensor networks; e.g., cryptanalysis, social networks, and recommender systems. Formally, a random key graph with $n$ nodes is constructed by assigning each node $X_n$ keys selected uniformly at random from a pool of $Y_n$ keys and then putting an undirected edge between any two nodes sharing at least one key. Considerable progress has been made in the literature to analyze connectivity and $k$-connectivity of random key graphs, where $k$-connectivity of a graph ensures connectivity even after the removal of $k$ nodes or $k$ edges. Yet, it still remains an open question for $k$-connectivity in random key graphs under $X_n \\geq 2$ and $X_n = o(\\sqrt{\\ln n})$ (the case of $X_n=1$ is trivial). In this paper, we answer the a...

  5. A systematic framework for functional connectivity measures

    Directory of Open Access Journals (Sweden)

    Huifang Elizabeth Wang

    2014-12-01

    Full Text Available Various methods have been proposed to characterize the functional connectivity between nodes in a network measured with different modalities (electrophysiology, functional magnetic resonance imaging etc.. Since different measures of functional connectivity yield different results for the same dataset, it is important to assess when and how they can be used. In this work, we provide a systematic framework for evaluating the performance of a large range of functional connectivity measures – based upon a comprehensive portfolio of models generating measurable responses. Specifically, we benchmarked 42 methods using 10,000 simulated datasets from 5 different types of generative models with different connectivity structures. Since all functional connectivity methods require the setting of some parameters (window size and number, model order etc., we first optimized these parameters using performance criteria based upon (threshold free ROC analysis. We then evaluated the performance of the methods on data simulated with different types of models. Finally, we assessed the performance of the methods against different levels of signal-to-noise ratios and network configurations. A MATLAB toolbox is provided to perform such analyses using other methods and simulated datasets.

  6. Pig genome sequence - analysis and publication strategy

    DEFF Research Database (Denmark)

    Archibald, Alan L.; Bolund, Lars; Churcher, Carol;

    2010-01-01

    BACKGROUND: The pig genome is being sequenced and characterised under the auspices of the Swine Genome Sequencing Consortium. The sequencing strategy followed a hybrid approach combining hierarchical shotgun sequencing of BAC clones and whole genome shotgun sequencing. RESULTS: Assemblies......) is under construction and will incorporate whole genome shotgun sequence (WGS) data providing > 30x genome coverage. The WGS sequence, most of which comprise short Illumina/Solexa reads, were generated from DNA from the same single Duroc sow as the source of the BAC library from which clones were...

  7. Stream cipher based on GSS sequences

    Institute of Scientific and Technical Information of China (English)

    HU Yupu; XIAO Guozhen

    2004-01-01

    Generalized self-shrinking sequences, simply named the GSS sequences,are novel periodic sequences that have many advantages in cryptography. In this paper,we give several results about GSS sequence's application to cryptography. First, we give a simple method for selecting those GSS sequences whose least periods reach the maximum. Second, we give a method for describing and computing the auto-correlation coefficients of GSS sequences. Finally, we point out that some GSS sequences, when used as stream ciphers, have a security weakness.

  8. De novo backbone and sequence design of an idealized alpha/beta-barrel protein: Evidence of stable tertiary structure

    OpenAIRE

    Offredi, Fabrice; Dubail, Fabien; Kischel, Philippe; Sarinski, K.; Stern, A S; Van de Weerdt, Cécile; Hoch, J. C.; Prosperi, Christelle; François, Jean-Marie; Mayo, S. L.; Martial, Joseph

    2003-01-01

    We have designed, synthesized, and characterized a 216 amino acid residue sequence encoding a putative idealized alpha/beta-barrel protein. The design was elaborated in two steps. First, the idealized backbone was defined with geometric parameters representing our target fold: a central eight parallel-stranded beta-sheet surrounded by eight parallel alpha-helices, connected together with short structural turns on both sides of the barrel. An automated sequence selection algorithm, based on th...

  9. The Toothpick Sequence and Other Sequences from Cellular Automata

    CERN Document Server

    Applegate, David; Sloane, N J A

    2010-01-01

    A two-dimensional arrangement of toothpicks is constructed by the following iterative procedure. At stage 1, place a single toothpick of length 1 on a square grid, aligned with the y-axis. At each subsequent stage, for every exposed toothpick end, place an orthogonal toothpick centered at that end. The resulting structure has a fractal-like appearance. We will analyze the toothpick sequence, which gives the total number of toothpicks after n steps. We also study several related sequences that arise from enumerating active cells in cellular automata. Some unusual recurrences appear: a typical example is that instead of the Fibonacci recurrence, which we may write as a(2+i) = a(i) + a(i+1), we set n = 2^k+i (0 = 0} (1+x^{2^k-1}+2x^{2^k}) and variations thereof.

  10. Orthogonal Basis Spreading Sequence for Optimal CDMA

    OpenAIRE

    Tsuda, Hirofumi; Umeno, Ken

    2016-01-01

    Recently, new spreading sequences have been proposed to multiplex the capacity of users. In particular, Weyl spreading sequences have the larger capacity of users than Gold code. This paper shows that Weyl spreading sequences appear in bit restoring model and they are orthogonal basis in the particular situation. This result shows the reason why they have the large capacity and that any spreading sequence are expressed as the sum of Weyl spreading sequences.

  11. Hardware Acceleration of Bioinformatics Sequence Alignment Applications

    OpenAIRE

    Hasan, L.

    2011-01-01

    Biological sequence alignment is an important and challenging task in bioinformatics. Alignment may be defined as an arrangement of two or more DNA or protein sequences to highlight the regions of their similarity. Sequence alignment is used to infer the evolutionary relationship between a set of protein or DNA sequences. An accurate alignment can provide valuable information for experimentation on the newly found sequences. It is indispensable in basic research as well as in practical applic...

  12. Hardware Accelerated Sequence Alignment with Traceback

    OpenAIRE

    Scott Lloyd; Snell, Quinn O

    2009-01-01

    Biological sequence alignment is an essential tool used in molecular biology and biomedical applications. The growing volume of genetic data and the complexity of sequence alignment present a challenge in obtaining alignment results in a timely manner. Known methods to accelerate alignment on reconfigurable hardware only address sequence comparison, limit the sequence length, or exhibit memory and I/O bottlenecks. A space-efficient, global sequence alignment algorithm and architecture is pres...

  13. A review of variables of urban street connectivity for spatial connection

    Science.gov (United States)

    Mohamad, W. S. N. W.; Said, I.

    2014-02-01

    Several studies on street connectivity in cities and towns have been modeled on topology, morphology, technology and psychology of people living in the urban environment. Street connectivity means the connection of streets that offers people alternative routes. However, there emerge difficulties to determine the suitable variables and analysis to be chosen in defining the accurate result for studies street connectivity. The aim of this paper is to identify variables of street connectivity by applying GIS and Space Syntax. This paper reviews the variables of street connectivity from 15 past articles done in 1990s to early 2000s from journals of nine disciplines on Environment and Behavior, Planning and Design, Computers, Environment and Urban Systems, Applied Earth Observation and Geo-information, Environment and Planning, Physica A: Statistical Mechanics and its Applications, Environmental Psychology, Social Science and Medicine and Building and Environment. From the review, there are four variables found for street connectivity: link (streets-streets, street-nodes or node-streets, nodes-nodes), accessibility, least-angle, and centrality. Space syntax and GIS are suitable tools to analyze the four variables relating to systematic street systems for pedestrians. This review implies that planners of the street systems, in the aspect of street connectivity in cities and towns, should consider these four variables.

  14. Connecting to Our Community: Utilizing Photovoice as a Pedagogical Tool to Connect College Students to Science

    Science.gov (United States)

    Cook, Kristin; Quigley, Cassie

    2013-01-01

    In this study, we investigated the ways in which university students connected with science through the use of photovoice (Wang & Burris, 1994) as a pedagogical tool. Results indicated that students came to appreciate their connections to the science that operates in their lives as they reflected on and became empowered with regard to the science…

  15. A review of variables of urban street connectivity for spatial connection

    International Nuclear Information System (INIS)

    Several studies on street connectivity in cities and towns have been modeled on topology, morphology, technology and psychology of people living in the urban environment. Street connectivity means the connection of streets that offers people alternative routes. However, there emerge difficulties to determine the suitable variables and analysis to be chosen in defining the accurate result for studies street connectivity. The aim of this paper is to identify variables of street connectivity by applying GIS and Space Syntax. This paper reviews the variables of street connectivity from 15 past articles done in 1990s to early 2000s from journals of nine disciplines on Environment and Behavior, Planning and Design, Computers, Environment and Urban Systems, Applied Earth Observation and Geo-information, Environment and Planning, Physica A: Statistical Mechanics and its Applications, Environmental Psychology, Social Science and Medicine and Building and Environment. From the review, there are four variables found for street connectivity: link (streets-streets, street-nodes or node-streets, nodes-nodes), accessibility, least-angle, and centrality. Space syntax and GIS are suitable tools to analyze the four variables relating to systematic street systems for pedestrians. This review implies that planners of the street systems, in the aspect of street connectivity in cities and towns, should consider these four variables

  16. Healthcare e-commerce: connecting with patients.

    Science.gov (United States)

    Joslyn, J S

    2001-01-01

    Electronically connecting with patients is a challenging frontier at which technical hurdles are probably exceeded by political, legal, and other barriers. The rise of consumerism, however, compels a response focused more on revenue and strategic advantage than on pure cost savings. Among the difficulties faced by providers is choosing among various models of connectivity and component function. Emerging models include "free-floating" personal medical records largely independent of the office-based physician, systems with compatible and intertwined physician and consumer relationships using an application services provider office practice system, and systems that connect patients and providers through e-mail, office triage, prescription refills, scheduling, and so on. This article discusses these and other combinations of technology that significantly overcome the barriers involved and that may be woven together to provide solutions uniquely suited to various competitive situations.

  17. AMTEC vapor-vapor series connected cells

    Science.gov (United States)

    Underwood, Mark L.; Williams, Roger M.; Ryan, Margaret A.; Nakamura, Barbara J.; Oconnor, Dennis E.

    1995-08-01

    An alkali metal thermoelectric converter (AMTEC) having a plurality of cells structurally connected in series to form a septum dividing a plenum into two chambers, and electrically connected in series, is provided with porous metal anodes and porous metal cathodes in the cells. The cells may be planar or annular, and in either case a metal alkali vapor at a high temperature is provided to the plenum through one chamber on one side of the wall and returned to a vapor boiler after condensation at a chamber on the other side of the wall in the plenum. If the cells are annular, a heating core may be placed along the axis of the stacked cells. This arrangement of series-connected cells allows efficient generation of power at high voltage and low current.

  18. LR: Compact connectivity representation for triangle meshes

    Energy Technology Data Exchange (ETDEWEB)

    Gurung, T; Luffel, M; Lindstrom, P; Rossignac, J

    2011-01-28

    We propose LR (Laced Ring) - a simple data structure for representing the connectivity of manifold triangle meshes. LR provides the option to store on average either 1.08 references per triangle or 26.2 bits per triangle. Its construction, from an input mesh that supports constant-time adjacency queries, has linear space and time complexity, and involves ordering most vertices along a nearly-Hamiltonian cycle. LR is best suited for applications that process meshes with fixed connectivity, as any changes to the connectivity require the data structure to be rebuilt. We provide an implementation of the set of standard random-access, constant-time operators for traversing a mesh, and show that LR often saves both space and traversal time over competing representations.

  19. Healthcare e-commerce: connecting with patients.

    Science.gov (United States)

    Joslyn, J S

    2001-01-01

    Electronically connecting with patients is a challenging frontier at which technical hurdles are probably exceeded by political, legal, and other barriers. The rise of consumerism, however, compels a response focused more on revenue and strategic advantage than on pure cost savings. Among the difficulties faced by providers is choosing among various models of connectivity and component function. Emerging models include "free-floating" personal medical records largely independent of the office-based physician, systems with compatible and intertwined physician and consumer relationships using an application services provider office practice system, and systems that connect patients and providers through e-mail, office triage, prescription refills, scheduling, and so on. This article discusses these and other combinations of technology that significantly overcome the barriers involved and that may be woven together to provide solutions uniquely suited to various competitive situations. PMID:11338911

  20. Quantifying Riverscape Connectivity with Graph Theory

    Science.gov (United States)

    Carbonneau, P.; Milledge, D.; Sinha, R.; Tandon, S. K.

    2013-12-01

    Fluvial catchments convey fluxes of water, sediment, nutrients and aquatic biota. At continental scales, crustal topography defines the overall path of channels whilst at local scales depositional and/or erosional features generally determine the exact path of a channel. Furthermore, constructions such as dams, for either water abstraction or hydropower, often have a significant impact on channel networks.The concept of ';connectivity' is commonly invoked when conceptualising the structure of a river network.This concept is easy to grasp but there have been uneven efforts across the environmental sciences to actually quantify connectivity. Currently there have only been a few studies reporting quantitative indices of connectivity in river sciences, notably, in the study of avulsion processes. However, the majority of current work describing some form of environmental connectivity in a quantitative manner is in the field of landscape ecology. Driven by the need to quantify habitat fragmentation, landscape ecologists have returned to graph theory. Within this formal setting, landscape ecologists have successfully developed a range of indices which can model connectivity loss. Such formal connectivity metrics are currently needed for a range of applications in fluvial sciences. One of the most urgent needs relates to dam construction. In the developed world, hydropower development has generally slowed and in many countries, dams are actually being removed. However, this is not the case in the developing world where hydropower is seen as a key element to low-emissions power-security. For example, several dam projects are envisaged in Himalayan catchments in the next 2 decades. This region is already under severe pressure from climate change and urbanisation, and a better understanding of the network fragmentation which can be expected in this system is urgently needed. In this paper, we apply and adapt connectivity metrics from landscape ecology. We then examine the

  1. Evolution Strategies in the Multipoint Connections Routing

    Directory of Open Access Journals (Sweden)

    L. Krulikovska

    2010-09-01

    Full Text Available Routing of multipoint connections plays an important role in final cost and quality of a found connection. New algorithms with better results are still searched. In this paper, a possibility of using the evolution strategies (ES for routing is presented. Quality of found connection is evaluated from the view of final cost and time spent on a searching procedure. First, parametrical analysis of results of the ES are discussed and compared with the Prim’s algorithm, which was chosen as a representative of the deterministic routing algorithms. Second, ways for improving the ES are suggested and implemented. The obtained results are reviewed. The main improvements are specified and discussed in conclusion.

  2. Functional connectivity of emotional processing in depression.

    LENUS (Irish Health Repository)

    Carballedo, Angela

    2012-02-01

    OBJECTIVES: The aim of the study is to map a neural network of emotion processing and to identify differences in major depression compared to healthy controls. It is hypothesized that intentional perception of emotional faces activates connections between amygdala (Demir et al.), orbitofrontal cortex (OFC), anterior cingulate cortex (ACC) and prefrontal cortex (PFC) and that frontal-amygdala connections are altered in major depressive disorder (MDD). METHODS: Fifteen medication-free patients with MDD and fifteen healthy controls were enrolled. All subjects were assessed using the same face-matching functional Magnetic Resonance Imaging (fMRI) task, known to involve those areas. Brain activations were obtained using Statistical Parametric Mapping version 5 (SPM5) for data analysis and MARSBAR for extracting of fMRI time series. Then data was analyzed using structural equation modeling (SEM). RESULTS: A valid model was established for the left and the right hemispheres showing a circuit involving ACC, OFC, PFC and AMY. The left hemisphere shows significant lower connectivity strengths in patients than controls, for the pathway that goes from AMY to the OF11, and a trend of higher connectivity in patients for the path that goes from the PF9 to the OF11. In the right hemisphere, patients show lower connectivity coefficients in the paths from the AMY to OF11, from the AMY to ACC, and from the ACC to PF9. By the contrary, controls show lower connectivity strengths for the path that goes from ACC to AMY. CONCLUSIONS: Functional disconnection between limbic and frontal brain regions could be demonstrated using structural equation modeling. The interpretation of these findings could be that there is an emotional processing bias with disconnection bilaterally between amygdala to orbitofrontal cortices and in addition a right disconnection between amygdala and ACC as well as between ACC and prefrontal cortex possibly in line with a more prominent role for the right hemisphere

  3. Sequence Planning for On-Orbit Assembly of Large Space Truss Structures in a Multirobot Environment

    Institute of Scientific and Technical Information of China (English)

    GUO Jifeng; WANG Ping; CUI Naigang

    2006-01-01

    An approach to sequence planning for on-orbit assembly of large space truss structures in a multirobot environment is presented. A hierarchical representation of large space truss structures at the structural volume element level and strut level is adopted. The representation of connectivity matrix and directed graph is respectively presented at the strut level and SVE level. The multirobot environment that consists of autonomous space robots and struts is supposed. Then the multirobot serial assembly strategy, assembly states, assembly tasks and assembly sequences are described. The assembly sequence planning algorithms at the strut level and SVE level are respectively discussed. The results of the simulations show that this approach is feasible and efficient. Two extensions of this approach include more accurate assessment of the efficiency representation and improvements in planning algorithm. In the future, the assembly sequence planning of more large space truss structures and complex multirobot environments and assembly tasks will be considered.

  4. Connected brains and minds – the UMCD repository for brain connectivity matrices

    Science.gov (United States)

    Brown, Jesse A.; Van Horn, John D.

    2016-01-01

    We describe the USC Multimodal Connectivity Database (http://umcd.humanconnectomeproject.org ), an interactive web-based platform for brain connectivity matrix sharing and analysis. The site enables users to download connectivity matrices shared by other users, upload matrices from their own published studies, or select a specific matrix and perform a realtime graph theory-based analysis and visualization of network properties. The data shared on the site span a broad spectrum of functional and structural brain connectivity information from humans across the entire age range (fetal to age 89), representing an array of different neuropsychiatric and neurodegenerative disease populations (autism spectrum disorder, ADHD, and APOE-4 carriers). An analysis combining 7 different datasets shared on the site illustrates the diversity of the data and the potential for yielding deeper insight by assessing new connectivity matrices with respect to population-wide network properties represented in the UMCD. PMID:26311606

  5. Connected brains and minds--The UMCD repository for brain connectivity matrices.

    Science.gov (United States)

    Brown, Jesse A; Van Horn, John D

    2016-01-01

    We describe the USC Multimodal Connectivity Database (http://umcd.humanconnectomeproject.org), an interactive web-based platform for brain connectivity matrix sharing and analysis. The site enables users to download connectivity matrices shared by other users, upload matrices from their own published studies, or select a specific matrix and perform a real-time graph theory-based analysis and visualization of network properties. The data shared on the site span a broad spectrum of functional and structural brain connectivity information from humans across the entire age range (fetal to age 89), representing an array of different neuropsychiatric and neurodegenerative disease populations (autism spectrum disorder, ADHD, and APOE-4 carriers). An analysis combining 7 different datasets shared on the site illustrates the diversity of the data and the potential for yielding deeper insight by assessing new connectivity matrices with respect to population-wide network properties represented in the UMCD. PMID:26311606

  6. AARP iPad Tech to Connect

    CERN Document Server

    Boyd, Barbara

    2012-01-01

    The world is at your fingertips with iPad! AARP iPad: Tech to Connect introduces you to the world?s most popular tablet device, the iPad, and all the amazing things it has to offer. In clear, non-technical language, this book guides you through registering and setting up your iPad, getting acquainted with the multitouch interface, navigating around the screen, finding and downloading apps, reading books, listening to music, watching videos, surfing the web, and communicating with friends and family. Developed in partnership with AARP and dedicated to helping readers stay connected with friends

  7. Supervised hub-detection for brain connectivity

    DEFF Research Database (Denmark)

    Kasenburg, Niklas; Liptrot, Matthew George; Reislev, Nina Linde;

    2016-01-01

    A structural brain network consists of physical connections between brain regions. Brain network analysis aims to find features associated with a parameter of interest through supervised prediction models such as regression. Unsupervised preprocessing steps like clustering are often applied......-detection and a linear regression using the original network connections as features. The results show that the SHD is able to retain regression performance, while still finding hubs that represent the underlying variation in the population. Although here we applied the SHD to brain networks, it can be applied to any...

  8. Political Connections and Investment in Rural Vietnam

    DEFF Research Database (Denmark)

    Markussen, Thomas; Tarp, Finn

    behaviour in environments with developing institutions and markets. They also suggest the presence of an untapped potential for economic development: if households without connections could obtain equally strong property rights and access to credit and insurance as the well-connected households, investment......This paper uses household panel data from rural Vietnam to explore the effects of having a relative in a position of political or bureaucratic power on farmers’ agricultural investment decisions. Our main result is that households significantly increase their investment in land improvement...

  9. Cold electrical connection for FAIR/ SIS100

    CERN Document Server

    Kauschke, M; Quack, H

    2009-01-01

    The Facility of Antiproton and Ion Research (FAIR) will be an international centre for atomic-, plasma- and nuclear- physics, located next to Gesellschaft für Schwerionenforschung (GSI), Darmstadt. FAIR will be composed from two synchrotrons and four storage rings. Both synchrotrons, SIS100 and SIS300, are designed with superconducting magnets. For radiation protection reasons and landscaping restrictions the synchrotrons will be placed underground, whereas the power supplies will be placed within three service buildings above ground level. To save space and refrigeration power a superconducting electrical connection will be implemented. The mechanical and thermal design of this connection will be presented in the paper.

  10. The canonical connection in quantum mechanics

    CERN Document Server

    Lévai, Peter; Tsutsui, I; Levay, Peter; McMullan, David; Tsutsui, Izumi

    1995-01-01

    In this paper we investigate the form of induced gauge fields that arises in two types of quantum systems. In the first we consider quantum mechanics on coset spaces G/H, and argue that G-invariance is central to the emergence of the H-connection as induced gauge fields in the different quantum sectors. We then demonstrate why the same connection, now giving rise to the non-abelian generalization of Berry's phase, can also be found in systems which have slow variables taking values in such a coset space.

  11. The canonical connection in quantum mechanics

    Energy Technology Data Exchange (ETDEWEB)

    Levay, P. [Budapesti Mueszaki Egyetem, Budapest (Hungary); Mcmullan, D.; Tsutsui, Izumi

    1995-04-01

    In this paper we investigate the form of induced gauge fields that arises in two types of quantum systems. In the first we consider quantum mechanics on coset spaces G/H, and argue that G-invariance is central to the emergence of the H-connection as induced gauge fields in the different quantum sectors. We then demonstrate why the same connection, now giving rise to the non-abelian generalization of Berry`s phase, can also be found in systems which have slow variables taking values in such a coset space. (author).

  12. Coupled Intrinsic Connectivity Distribution analysis: a method for exploratory connectivity analysis of paired FMRI data.

    Directory of Open Access Journals (Sweden)

    Dustin Scheinost

    Full Text Available We present a novel voxel-based connectivity approach for paired functional magnetic resonance imaging (fMRI data collected under two different conditions labeled the Coupled Intrinsic Connectivity Distribution (coupled-ICD. Our proposed method jointly models both conditions to incorporate additional paired information into the connectivity metric. Voxel-based connectivity holds promise as a clinical tool to characterize a wide range of neurological and psychiatric diseases, and monitor their treatment. As such, examining paired connectivity data such as scans acquired pre- and post-intervention is an important application for connectivity methodologically. When presented with data from paired conditions, conventional voxel-based methods analyze each condition separately. However, summarizing each connection separately can misrepresent patterns of changes in connectivity. We show that commonly used methods can underestimate functional changes and subsequently introduce and evaluate our solution to this problem, the coupled-ICD metric, using two studies: 1 healthy controls scanned awake and under anesthesia, and 2 cocaine-dependent subjects and healthy controls scanned while being presented with relaxing or drug-related imagery cues. The coupled-ICD approach detected differences between paired conditions in similar brain regions as the conventional approaches while also revealing additional changes in regions not identified using conventional voxel-based connectivity analyses. Follow-up seed-based analyses on data independent from the voxel-based results also showed connectivity differences between conditions in regions detected by coupled-ICD. This approach of jointly analyzing paired resting-state scans provides a new and important tool with many applications for clinical and basic neuroscience research.

  13. Nonparametric Inference for Periodic Sequences

    KAUST Repository

    Sun, Ying

    2012-02-01

    This article proposes a nonparametric method for estimating the period and values of a periodic sequence when the data are evenly spaced in time. The period is estimated by a "leave-out-one-cycle" version of cross-validation (CV) and complements the periodogram, a widely used tool for period estimation. The CV method is computationally simple and implicitly penalizes multiples of the smallest period, leading to a "virtually" consistent estimator of integer periods. This estimator is investigated both theoretically and by simulation.We also propose a nonparametric test of the null hypothesis that the data have constantmean against the alternative that the sequence of means is periodic. Finally, our methodology is demonstrated on three well-known time series: the sunspots and lynx trapping data, and the El Niño series of sea surface temperatures. © 2012 American Statistical Association and the American Society for Quality.

  14. Cassini Mission Sequence Subsystem (MSS)

    Science.gov (United States)

    Alland, Robert

    2011-01-01

    This paper describes my work with the Cassini Mission Sequence Subsystem (MSS) team during the summer of 2011. It gives some background on the motivation for this project and describes the expected benefit to the Cassini program. It then introduces the two tasks that I worked on - an automatic system auditing tool and a series of corrections to the Cassini Sequence Generator (SEQ_GEN) - and the specific objectives these tasks were to accomplish. Next, it details the approach I took to meet these objectives and the results of this approach, followed by a discussion of how the outcome of the project compares with my initial expectations. The paper concludes with a summary of my experience working on this project, lists what the next steps are, and acknowledges the help of my Cassini colleagues.

  15. Genome Sequence of Mycobacteriophage Momo.

    Science.gov (United States)

    Pope, Welkin H; Bina, Elizabeth A; Brahme, Indraneel S; Hill, Amy B; Himmelstein, Philip H; Hunsicker, Sara M; Ish, Amanda R; Le, Tinh S; Martin, Mary M; Moscinski, Catherine N; Shetty, Sameer A; Swierzewski, Tomasz; Iyengar, Varun B; Kim, Hannah; Schafer, Claire E; Grubb, Sarah R; Warner, Marcie H; Bowman, Charles A; Russell, Daniel A; Hatfull, Graham F

    2015-06-18

    Momo is a newly discovered phage of Mycobacterium smegmatis mc(2)155. Momo has a double-stranded DNA genome 154,553 bp in length, with 233 predicted protein-encoding genes, 34 tRNA genes, and one transfer-messenger RNA (tmRNA) gene. Momo has a myoviral morphology and shares extensive nucleotide sequence similarity with subcluster C1 mycobacteriophages.

  16. Sequencing Trade and Monetary Integration

    OpenAIRE

    Richard Pomfret

    2005-01-01

    Regional integration for at least the last sixty years has focused on trade integration. Balassa’s canonical taxonomy of regional trading arrangements is often interpreted as a sequence from free trade area through customs union and common market to economic union. In the 1980s the concept of deep integration went beyond trade with its focus on policy harmonization, which came to include monetary integration, but it presupposed trade integration as the first step in the regional integration s...

  17. Linear Connections on Normal Almost Contact Manifolds with Norden Metric

    CERN Document Server

    Teofilova, Marta

    2011-01-01

    Families of linear connections are constructed on almost contact manifolds with Norden metric. An analogous connection to the symmetric Yano connection is obtained on a normal almost contact manifold with Norden metric and closed structural 1-form. The curvature properties of this connection are studied on two basic classes of normal almost contact manifolds with Norden metric.

  18. On the correspondence between infinitesimal and integral description of connections

    International Nuclear Information System (INIS)

    We point out that there is no equivalence between infinitesimal (connection form or distribution of horizontal subspaces) and integral (path formalism) description of connections. There will be a one-to-one correspondence if the notion of (infinitesimal) connection is generalized. This is done by introducing ''infinitesimally non-linear'' connections. (author)

  19. Sequencing technologies to maximize recovery

    Energy Technology Data Exchange (ETDEWEB)

    Dusseault, M.B. [Waterloo Univ., ON (Canada)

    2006-07-01

    The deliberate sequencing of extraction technologies for viscous oil may optimize financial returns. Sequencing is based on an understanding that some technologies improve reservoir transport parameters through phenomena such as shear dilation; fracturing of shales through high pressure injection; thermal consolidation; shear rupture of clay dustings and shale laminae; and the dislodging of pore blocking agents. Cold heavy oil production with sand (CHOPS) increases reservoir permeability, porosity and compressibility, and can alter stress fields and flow paths, which can in turn lead to more effective subsequent thermal or gravity methods of extraction. High pressure thermal extraction processes such as steam flood (SF) and cyclic steam stimulation (CSS) generate reservoir dilation and viscosity reduction which mean that subsequent gravity methods such as VAPEX will achieve increased extraction efficiency. Massive dilation during cyclic injection phases means that recompaction drive mechanisms will improve recovery rates and recovery factors. Successful planning means that the physics and impacts on the reservoir of all commercial technologies must be understood, and initial systems of exploitation should be designed to minimize future well needs. It was concluded that if implemented correctly, the impact of sequencing on technically recoverable reserves estimates in heavy oil will be considerable. Recoverable reserves increases exceeding a trillion barrels are anticipated. 12 refs., 8 figs.

  20. Sequencing technologies to maximize recovery

    International Nuclear Information System (INIS)

    The deliberate sequencing of extraction technologies for viscous oil may optimize financial returns. Sequencing is based on an understanding that some technologies improve reservoir transport parameters through phenomena such as shear dilation; fracturing of shales through high pressure injection; thermal consolidation; shear rupture of clay dustings and shale laminae; and the dislodging of pore blocking agents. Cold heavy oil production with sand (CHOPS) increases reservoir permeability, porosity and compressibility, and can alter stress fields and flow paths, which can in turn lead to more effective subsequent thermal or gravity methods of extraction. High pressure thermal extraction processes such as steam flood (SF) and cyclic steam stimulation (CSS) generate reservoir dilation and viscosity reduction which mean that subsequent gravity methods such as VAPEX will achieve increased extraction efficiency. Massive dilation during cyclic injection phases means that recompaction drive mechanisms will improve recovery rates and recovery factors. Successful planning means that the physics and impacts on the reservoir of all commercial technologies must be understood, and initial systems of exploitation should be designed to minimize future well needs. It was concluded that if implemented correctly, the impact of sequencing on technically recoverable reserves estimates in heavy oil will be considerable. Recoverable reserves increases exceeding a trillion barrels are anticipated. 12 refs., 8 figs