WorldWideScience

Sample records for biophysconnector connecting sequence

  1. Detecting Emotions from Connected Action Sequences

    Science.gov (United States)

    Bernhardt, Daniel; Robinson, Peter

    In this paper we deal with the problem of detecting emotions from the body movements produced by naturally connected action sequences. Although action sequences are one of the most common forms of body motions in everyday scenarios their potential for emotion recognition has not been explored in the past. We show that there are fundamental differences between actions recorded in isolation and in natural sequences and demonstrate a number of techniques which allow us to correctly label action sequences with one of four emotions up to 86% of the time. Our results bring us an important step closer to recognizing emotions from body movements in natural scenarios.

  2. Cortico-cerebellar functional connectivity and sequencing of movements in schizophrenia

    Directory of Open Access Journals (Sweden)

    Kasparek Tomas

    2012-03-01

    Full Text Available Abstract Background Abnormal execution of several movements in a sequence is a frequent finding in schizophrenia. Successful performance of such motor acts requires correct integration of cortico-subcortical processes, particularly those related to cerebellar functions. Abnormal connectivity between cortical and cerebellar regions with resulting cognitive dysmetria has been proposed as the core dysfunction behind many signs and symptoms of schizophrenia. The aim of the present study was to assess if these proposed abnormalities in connectivity are a unifying feature of schizophrenia, or, rather, reflect a specific symptom domain of a heterogeneous disease. We predicted that abnormal functional connectivity between the motor cortex and cerebellum would be linked with abnormal performance of movement sequencing. Methods We examined 24 schizophrenia patients (SCH and 24 age-, sex-, and handedness-matched healthy controls (HC using fMRI during a modified finger-tapping task. The ability to perform movement sequencing was tested using the Neurological Evaluation Scale (NES. The subjects were categorized into two groups, with (SQ+ and without (SQ- movement sequencing abnormalities, according to the NES-SQ score. The effects of diagnosis and movement sequencing abnormalities on the functional connectivity parameters between the motor cortex and cerebellum (MC-CRBL and the supplementary motor cortex and cerebellum (SMA-CRBL activated during the motor task were analyzed. Results We found no effect of diagnosis on the functional connectivity measures. There was, however, a significant effect on the SQ group: SQ + patients showed a lower level of MC-CRBL connectivity than SQ- patients and healthy controls. Moreover, the level of MC-CRBL and SMA-CRBL negatively correlated with the magnitude of NES-SQ abnormalities, but with no other NES domain. Conclusions Abnormal cortico-cerebellar functional connectivity during the execution of a motor task is linked

  3. Negative sequence current control in wind power plants with VSC-HVDC connection

    DEFF Research Database (Denmark)

    Chaudhary, Sanjay; Teodorescu, Remus; Rodriguez, Pedro;

    2012-01-01

    Large offshore wind power plants may have multi-MW wind turbine generators (WTG) equipped with full-scale converters (FSC) and voltage source converter (VSC) based high voltaage direct-current (HVDC) transmission for grid connection. The power electronic converters in theWTG-FSC and the VSC-HVDC...... allow fast current control in the offshore grid. This paper presents a method of controlling the negative sequence current injection into the offshore grid from the VSC-HVDC as well as WTG-FSCs. This would minimize the power oscillations and hence reduce the dc voltage overshoots in the VSC-HVDC system...... sequence current control mitigates the power oscillations and therefore limits the dc voltage excursions in the VSC-HVDC system during the asymmetric faults....

  4. Use of hourly sequences of global radiation for simulation of photovoltaic systems grid connected

    Energy Technology Data Exchange (ETDEWEB)

    Sidrach de Cardona, M. [Dept. Fisica Aplicada 2, E.T.S.I., Univ. de Malaga (Spain); Mora Lopez, Ll. [Dept. Lenguajes y Ciencias de la Computacion, E.T.S.I., Univ. de Malaga (Spain)

    1996-12-31

    In this paper we analyse whether it is suitable to use hourly sequences of global radiation to study the performance of photovoltaic systems grid connected. The purpose of this paper is to quantify the error which is made on predicting the energy which a photovoltaic system connected to the grid, when the global radiation interval considered (which is an input value in our computations) varies. Using a simulation model we have studied how much energy is produced. The input values we considered are: values of daily global radiation, values of hourly global radiation and global radiation intervals of 10 minutes. These data have been recorded by the metereological station in Malaga of Andalusian Institute for renewable energies. In each interval, the simulation model takes into account the variations in module temperature as a function of ambient temperature. Therefore, when using daily values the model takes into account the average value of ambient temperature during sun hours and when using other values the model takes into account the average of this parameter in the interval under consideration. The nominal power considered is 2 kWp. The model we use assumes that the working point of the installation is always the maximum power point of modules and that all produced energy is injected in the grid. We also study the influence on this error when different set point of minimum input power for inverter starting (threshold value) are used. (orig.)

  5. A Note on Stability of a Linear Functional Equation of Second Order Connected with the Fibonacci Numbers and Lucas Sequences

    Directory of Open Access Journals (Sweden)

    Janusz Brzdęk

    2010-01-01

    Full Text Available We prove the Hyers-Ulam stability of a second-order linear functional equation in single variable (with constant coefficients that is connected with the Fibonacci numbers and Lucas sequences. In this way we complement, extend, and/or improve some recently published results on stability of that equation.

  6. Evolutionary connections of biological kingdoms based on protein and nucleic acid sequence evidence

    Science.gov (United States)

    Dayhoff, M. O.

    1983-01-01

    Prokaryotic and eukaryotic evolutionary trees are developed from protein and nucleic-acid sequences by the methods of numerical taxonomy. Trees are presented for bacterial ferredoxins, 5S ribosomal RNA, c-type cytochromes , cytochromes c2 and c', and 5.8S ribosomal RNA; the implications for early evolution are discussed; and a composite tree showing the branching of the anaerobes, aerobes, archaebacteria, and eukaryotes is shown. Single lines are found for all oxygen-evolving photosynthetic forms and for the salt-loving and high-temperature forms of archaebacteria. It is argued that the eukaryote mitochondria, chloroplasts, and cytoplasmic host material are descended from free-living prokaryotes that formed symbiotic associations, with more than one symbiotic event involved in the evolution of each organelle.

  7. Age-related differences in practice-dependent resting-state functional connectivity related to motor sequence learning.

    Science.gov (United States)

    Mary, Alison; Wens, Vincent; Op de Beeck, Marc; Leproult, Rachel; De Tiège, Xavier; Peigneux, Philippe

    2017-02-01

    Decreased neural plasticity is observed with healthy ageing in the primary sensorimotor (SM1) cortex thought to participate in motor learning and memory consolidation processes. In the present magnetoencephalography study, the post-training reorganization of resting-state functional connectivity (rsFC) and its relation with motor learning and early consolidation in 14 young (19-30 years) and 14 old (66-70 years) healthy participants were investigated. At the behavioral level, participants were trained on a motor sequence learning task then retested 20-30 min later for transient offline gains in performance. Using a sensorimotor seed-based approach, rsFC relying on beta band power envelope correlation was estimated immediately before and 10 min after the learning episode. Post-training changes in rsFC (from before to after learning) were correlated with motor learning performance and with the offline improvement in performance within the hour after learning. Young and old participants exhibited differential patterns of sensorimotor-related rsFC, bearing specific relationships with motor learning and consolidation. Our findings suggest that rsFC changes following learning reflect the offline processing of the new motor skill and contribute to the early memory consolidation within the hour after learning. Furthermore, differences in post-training changes in rsFC between young and old participants support the hypothesis that ageing modulates the neural circuits underlying the learning of a new motor skill and the early subsequent consolidation stages. Hum Brain Mapp 38:923-937, 2017. © 2016 Wiley Periodicals, Inc.

  8. Local amino acid sequence patterns dominate the heterogeneous phenotype for the collagen connective tissue disease Osteogenesis Imperfecta resulting from Gly mutations.

    Science.gov (United States)

    Xiao, Jianxi; Yang, Zhangfu; Sun, Xiuxia; Addabbo, Rayna; Baum, Jean

    2015-10-01

    Osteogenesis Imperfecta (OI), a hereditary connective tissue disease in collagen that arises from a single Gly → X mutation in the collagen chain, varies widely in phenotype from perinatal lethal to mild. It is unclear why there is such a large variation in the severity of the disease considering the repeating (Gly-X-Y)n sequence and the uniform rod-like structure of collagen. We systematically evaluate the effect of local (Gly-X-Y)n sequence around the mutation site on OI phenotype using integrated bio-statistical approaches, including odds ratio analysis and decision tree modeling. We show that different Gly → X mutations have different local sequence patterns that are correlated with lethal and nonlethal phenotypes providing a mechanism for understanding the sensitivity of local context in defining lethal and non-lethal OI. A number of important trends about which factors are related to OI phenotypes are revealed by the bio-statistical analyses; most striking is the complementary relationship between the placement of Pro residues and small residues and their correlation to OI phenotype. When Pro is present or small flexible residues are absent nearby a mutation site, the OI case tends to be lethal; when Pro is present or small flexible residues are absent further away from the mutation site, the OI case tends to be nonlethal. The analysis also reveals the dominant role of local sequence around mutation sites in the Major Ligand Binding Regions that are primarily responsible for collagen binding to its receptors and shows that non-lethal mutations are highly predicted by local sequence considerations alone whereas lethal mutations are not as easily predicted and may be a result of more complex interactions. Understanding the sequence determinants of OI mutations will enhance genetic counseling and help establish which steps in the collagen hierarchy to target for drug therapy.

  9. Connected Traveler

    Energy Technology Data Exchange (ETDEWEB)

    Schroeder, Alex

    2015-11-01

    The Connected Traveler project is a multi-disciplinary undertaking that seeks to validate potential for transformative transportation system energy savings by incentivizing efficient traveler behavior. This poster outlines various aspects of the Connected Traveler project, including market opportunity, understanding traveler behavior and decision-making, automation and connectivity, and a projected timeline for Connected Traveler's key milestones.

  10. Improvement of Zero-sequence Directional Component for Parallel Lines with Magnetically Strong and Electrically Weak Connection%平行线弱电强磁下零序方向元件的改进

    Institute of Scientific and Technical Information of China (English)

    张琦兵

    2013-01-01

    平行线在弱电强磁的影响下,相邻线接地故障时可能会引起本线零序方向纵联保护的误动.文中分析了目前克服弱电强磁所采取的解决方案,指出消除零序方向元件比相电压中零序互感电压是防止零序方向保护误动的一种有效手段.根据上述原理,提出了2种新型零序方向保护方案.考虑零序电压与母线相电压受到相同的零序互感影响,引入非故障相电压差、零序电压与故障相电压之差2种电压作为比相参考电压,从而形成不受零序互感影响的零序方向保护判据.PSCAD/EMTDC的仿真分析表明,文中提出的新保护方案在平行线弱电强磁时能保证可靠不误动.%Under the impact of parallel lines with magnetically strong and electrically weak connection, the false tripping of the league zero-sequence directional protection happens when ground faults occur on another line of the parallel lines. The current solution methodologies are analyzed. This problem is caused by the zero-sequence mutual potential between two lines. This can be solved by using polar voltages which do not contain zero-sequence mutual in zero-sequence directional protection. Based on this principle, two novel methods of zero-sequence directional protection are proposed using non-fault phase voltage difference ae well as zero-sequence voltage and fault phase voltage difference, thus the zero-sequence directional protection criteria are formed without the impact of zero-sequence mutual inductance. The feasibility of new zero-sequence directional protection schemes are verified by PSCAD/EMTDC simulations.

  11. A Tale of Two Anomalies: Depletion, Dispersion, and the Connection Between the Stellar Lithium Spread and Inflated Radii on the Pre-Main Sequence

    CERN Document Server

    Somers, Garrett

    2014-01-01

    We investigate lithium depletion in standard stellar models (SSMs) and main sequence (MS) open clusters, and explore the origin of the Li dispersion in young, cool stars of equal mass, age and composition. We first demonstrate that SSMs accurately predict the Li abundances of solar analogs at the zero-age main sequence (ZAMS) within theoretical uncertainties. We then measure the rate of MS Li depletion by removing the [Fe/H]-dependent ZAMS Li pattern from three well-studied clusters, and comparing the detrended data. MS depletion is found to be mass dependent, in the sense of more depletion at low mass. A dispersion in Li abundance at fixed $T_{\\rm eff}$ is nearly universal, and sets in by $\\sim$200 Myr. We discuss mass and age dispersion trends, and the pattern is mixed. We argue that metallicity impacts the ZAMS Li pattern, in agreement with theoretical expectations but contrary to the findings of some previous studies, and suggest Li as a test of cluster metallicity. Finally, we argue that a radius dispers...

  12. Exome sequencing identifies de novo pathogenic variants in FBN1 and TRPS1 in a patient with a complex connective tissue phenotype

    Science.gov (United States)

    Zastrow, Diane B.; Zornio, Patricia A.; Dries, Annika; Kohler, Jennefer; Fernandez, Liliana; Waggott, Daryl; Walkiewicz, Magdalena; Eng, Christine M.; Manning, Melanie A.; Farrelly, Ellyn; Fisher, Paul G.; Ashley, Euan A.; Bernstein, Jonathan A.

    2017-01-01

    Here we describe a patient who presented with a history of congenital diaphragmatic hernia, inguinal hernia, and recurrent umbilical hernia. She also has joint laxity, hypotonia, and dysmorphic features. A unifying diagnosis was not identified based on her clinical phenotype. As part of her evaluation through the Undiagnosed Diseases Network, trio whole-exome sequencing was performed. Pathogenic variants in FBN1 and TRPS1 were identified as causing two distinct autosomal dominant conditions, each with de novo inheritance. Fibrillin 1 (FBN1) mutations are associated with Marfan syndrome and a spectrum of similar phenotypes. TRPS1 mutations are associated with trichorhinophalangeal syndrome types I and III. Features of both conditions are evident in the patient reported here. Discrepant features of the conditions (e.g., stature) and the young age of the patient may have made a clinical diagnosis more difficult in the absence of exome-wide genetic testing. PMID:28050602

  13. A Tale of Two Anomalies: Depletion, Dispersion, and the Connection between the Stellar Lithium Spread and Inflated Radii on the Pre-main Sequence

    Science.gov (United States)

    Somers, Garrett; Pinsonneault, Marc H.

    2014-07-01

    We investigate lithium depletion in standard stellar models (SSMs) and main sequence (MS) open clusters, and explore the origin of the Li dispersion in young, cool stars of equal mass, age, and composition. We first demonstrate that SSMs accurately predict the Li abundances of solar analogs at the zero-age main sequence (ZAMS) within theoretical uncertainties. We then measure the rate of MS Li depletion by removing the [Fe/H]-dependent ZAMS Li pattern from three well-studied clusters, and comparing the detrended data. MS depletion is found to be mass-dependent, in the sense of more depletion at low mass. A dispersion in Li abundance at fixed T eff is nearly universal, and sets in by ~200 Myr. We discuss mass and age dispersion trends, and the pattern is mixed. We argue that metallicity impacts the ZAMS Li pattern, in agreement with theoretical expectations but contrary to the findings of some previous studies, and suggest Li as a test of cluster metallicity. Finally, we argue that a radius dispersion in stars of fixed mass and age, during the epoch of pre-MS Li destruction, is responsible for the spread in Li abundances and the correlation between rotation and Li in young cool stars, most well known in the Pleiades. We calculate stellar models, inflated to match observed radius anomalies in magnetically active systems, and the resulting range of Li abundances reproduces the observed patterns of young clusters. We discuss ramifications for pre-MS evolutionary tracks and age measurements of young clusters, and suggest an observational test.

  14. A tale of two anomalies: Depletion, dispersion, and the connection between the stellar lithium spread and inflated radii on the pre-main sequence

    Energy Technology Data Exchange (ETDEWEB)

    Somers, Garrett; Pinsonneault, Marc H., E-mail: somers@astronomy.ohio-state.edu, E-mail: pinsono@astronomy.ohio-state.edu [Department of Astronomy, The Ohio State University, 140 West 18th Avenue, Columbus, OH 43201 (United States)

    2014-07-20

    We investigate lithium depletion in standard stellar models (SSMs) and main sequence (MS) open clusters, and explore the origin of the Li dispersion in young, cool stars of equal mass, age, and composition. We first demonstrate that SSMs accurately predict the Li abundances of solar analogs at the zero-age main sequence (ZAMS) within theoretical uncertainties. We then measure the rate of MS Li depletion by removing the [Fe/H]-dependent ZAMS Li pattern from three well-studied clusters, and comparing the detrended data. MS depletion is found to be mass-dependent, in the sense of more depletion at low mass. A dispersion in Li abundance at fixed T{sub eff} is nearly universal, and sets in by ∼200 Myr. We discuss mass and age dispersion trends, and the pattern is mixed. We argue that metallicity impacts the ZAMS Li pattern, in agreement with theoretical expectations but contrary to the findings of some previous studies, and suggest Li as a test of cluster metallicity. Finally, we argue that a radius dispersion in stars of fixed mass and age, during the epoch of pre-MS Li destruction, is responsible for the spread in Li abundances and the correlation between rotation and Li in young cool stars, most well known in the Pleiades. We calculate stellar models, inflated to match observed radius anomalies in magnetically active systems, and the resulting range of Li abundances reproduces the observed patterns of young clusters. We discuss ramifications for pre-MS evolutionary tracks and age measurements of young clusters, and suggest an observational test.

  15. 正序基波提取器在光伏并网功率调节系统中的应用%Positive-sequence fundamental wave extractor applied in the PV grid-connected power conditioning system

    Institute of Scientific and Technical Information of China (English)

    杨艺云; 司传涛; 廖波; 周林

    2013-01-01

    The key for PV grid-connected power conditioning system to realize the uniform control of PV grid-connected and active filter is to correctly detect harmonic and reactive current and form grid-connected directive current. Considering distortion and frequency deviation of the actual grid voltage, to get the correct harmonic, reactive current and synchronous sine, the amplitude integral and selective characteristic of frequency are used to form the positive sequence fundamental extractor. The K in the positive sequence fundamental extractor is further analyzed, and then the operation expression of K is derived. If K is chosen properly, positive-sequence fundamental can be got correctly, and synchronous sine and cosine can be got without the phase lock loop. The detecting method for the harmonic, reactive power, and the sum of unsymmetrical components, as well as the grid-connected directive current composing method is analyzed to realize the active power injection, harmonic eliminating and reactive power compensation. The simulation in Matlab/Simulink verifies the correctness of the theoretical analysis. For the effect of K on the positive-sequence fundamental extracting, the miniwatt experiment is conducted to further verify the correctness of the method.%光伏并网功率调节系统实现光伏并网与有源滤波的统一控制,关键是谐波、无功电流的准确检测和并网指令电流的形成。考虑实际电网电压有畸变或频率偏差,为获得准确谐波、无功电流和同步正弦,利用幅值积分及其频率选择特性构成正序基波提取器,深入分析正序基波提取器中K参数设计方法,推导出K值的计算表达式,合理取K值,可准确提取正序基波,无需锁相环可得到同步正、余弦信号。分析了谐波、无功及不对称分量之和的检测方法和并网指令电流的合成方式,实现光伏有功注入与谐波抑制、无功补偿功能。最后进行Matlab/Simulink仿真

  16. About Connections

    Directory of Open Access Journals (Sweden)

    Kathleen S Rockland

    2015-05-01

    Full Text Available Despite the attention attracted by connectomics, one can lose sight of the very real questions concerning What are connections? In the neuroimaging community, structural connectivity is ground truth and underlying constraint on functional or effective connectivity. It is referenced to underlying anatomy; but, as increasingly remarked, there is a large gap between the wealth of human brain mapping and the relatively scant data on actual anatomical connectivity. Moreover, connections have typically been discussed as pairwise, point x projecting to point y (or: to points y and z, or more recently, in graph theoretical terms, as nodes or regions and the interconnecting edges. This is a convenient shorthand, but tends not to capture the richness and nuance of basic anatomical properties as identified in the classic tradition of tracer studies. The present short review accordingly revisits connectional weights, heterogeneity, reciprocity, topography, and hierarchical organization, drawing on concrete examples. The emphasis is on presynaptic long-distance connections, motivated by the intention to probe current assumptions and promote discussions about further progress and synthesis.

  17. Gendered Connections

    DEFF Research Database (Denmark)

    Jensen, Steffen Bo

    2009-01-01

    This article explores the gendered nature of urban politics in Cape Town by focusing on a group of female, township politicians. Employing the Deleuzian concept of `wild connectivity', it argues that these politically entrepreneurial women were able to negotiate a highly volatile urban landscape...... space also drew on quite traditional notions of female respectability. Furthermore, the article argues, the form of wild connectivity to an extent was a function of the political transition, which destabilized formal structures of gendered authority. It remains a question whether this form...... of connectivity might endure, as Capetonian politics assumes a post-apartheid structure....

  18. HR Connect

    Data.gov (United States)

    US Agency for International Development — HR Connect is the USAID HR personnel system which allows HR professionals to process HR actions related to employee's personal and position information. This system...

  19. Analysis of negative sequence and efficiency of balance transformer connected in Y and double trapezoids%星形-双梯形接线平衡变压器负序及效率分析

    Institute of Scientific and Technical Information of China (English)

    刘谋君; 罗隆福; 张志文; 宁志豪; 黄际元

    2012-01-01

    由于现有电气化铁道牵引负荷的不对称性,导致电力系统含有大量负序电流,牵引变压器运行效率不高.为了解决上述问题,对星形-双梯形接线三相变两相平衡变压器进行了研究,重点分析其负序特性及效率特性,并在不同负载工况下,探讨一次侧电流不平衡度及变压器运行效率的情况,得出了电流不平衡度为零且变压器运行效率最高的条件.通过MATLAB建模对其负序特性与效率特性进行了仿真研究,结果表明该变压器能抑制负序电流的产生.%The unbalanced load of electrified railway causes big negative sequence currents,resulting in low efficiency of traction transformer. The three-phase to two-phase balance transformer connected in Y and double trapezoids is researched and its characteristics of negative-sequence and efficiency are analyzed. The unbalance degree of the current at primary side and the operating efficiency of transformer are studied under different loads,and the conditions to achieve zero current unbalance degree with highest transformer efficiency are obtained. Simulative study is carried out with MATLAB and results show that the transformer suppresses the negative sequence current effectively.

  20. Connected Traveler

    Energy Technology Data Exchange (ETDEWEB)

    2016-06-01

    The Connected Traveler framework seeks to boost the energy efficiency of personal travel and the overall transportation system by maximizing the accuracy of predicted traveler behavior in response to real-time feedback and incentives. It is anticipated that this approach will establish a feedback loop that 'learns' traveler preferences and customizes incentives to meet or exceed energy efficiency targets by empowering individual travelers with information needed to make energy-efficient choices and reducing the complexity required to validate transportation system energy savings. This handout provides an overview of NREL's Connected Traveler project, including graphics, milestones, and contact information.

  1. Learning Connections

    Science.gov (United States)

    Royer, Regina D.; Richards, Patricia O.

    2005-01-01

    In this edition of Learning Connections, the authors show how technology can enhance study of weather patterns, reading comprehension, real-world training, critical thinking, health education, and art criticism. The following sections are included: (1) Social Studies; (2) Language Arts; (3) Computer Science and ICT; (4) Art; and (5) Health.…

  2. Getting Connected

    Science.gov (United States)

    Larkin, Patrick

    2011-01-01

    That the world outside schools is changing faster than ever is old news. Unfortunately, that the world "inside" schools is changing at a glacial pace is even older news. As school leaders, principals have an important choice to make as they move into the second decade of the 21st century. School leaders have a moral obligation to connect and…

  3. Order-theoretical connectivity

    Directory of Open Access Journals (Sweden)

    T. A. Richmond

    1990-01-01

    Full Text Available Order-theoretically connected posets are introduced and applied to create the notion of T-connectivity in ordered topological spaces. As special cases T-connectivity contains classical connectivity, order-connectivity, and link-connectivity.

  4. Connecting dots

    DEFF Research Database (Denmark)

    Murakami, Kyoko; Jacobs, Rachel L.

    2017-01-01

    of connecting the dots of recalled moments of individual family members lives and is geared towards building a family’s shared future for posterity. Lastly, we consider a wider implication of family reminiscence in terms of human development. http://www.infoagepub.com/products/Memory-Practices-and-Learning...... and Middleton, 1995). A reminiscence conversation is a dynamic talk-in-interaction, which can produce valuable learning experience for the participants involved. Reminiscence talk contains rich, personal, historic data that can reveal and inform family members of an unknown past. In this seminar/chapter, we...... shall present a discursive approach, a methodology that captures the dynamics of reminiscence. We analyse collected conversational data of British family members reminiscing on their past as a joint family activity. Through such talk-in-interaction, the family members develop continuity within...

  5. Connectivity of communication networks

    CERN Document Server

    Mao, Guoqiang

    2017-01-01

    This book introduces a number of recent developments on connectivity of communication networks, ranging from connectivity of large static networks and connectivity of highly dynamic networks to connectivity of small to medium sized networks. This book also introduces some applications of connectivity studies in network optimization, in network localization, and in estimating distances between nodes. The book starts with an overview of the fundamental concepts, models, tools, and methodologies used for connectivity studies. The rest of the chapters are divided into four parts: connectivity of large static networks, connectivity of highly dynamic networks, connectivity of small to medium sized networks, and applications of connectivity studies.

  6. Pythagorean Triples from Harmonic Sequences.

    Science.gov (United States)

    DiDomenico, Angelo S.; Tanner, Randy J.

    2001-01-01

    Shows how all primitive Pythagorean triples can be generated from harmonic sequences. Use inductive and deductive reasoning to explore how Pythagorean triples are connected with another area of mathematics. (KHR)

  7. Connection Strings Property on ADO Connection Object

    Institute of Scientific and Technical Information of China (English)

    Girigi Deogratias; Wu Min; Cao Weihua

    2002-01-01

    The connection string property on ADO connection object contains the information used to establish a connection to the data source. The syntax, the keyword of that information must be in specific format. Depending on the type of data you are connecting to, you need either specify an OLEDB provider or use on ODBC driver. The biggest problem, the industries face is the proliferation of data access interfaces, and the complexity of creating,maintaining and programming against them, and the network problem when communicating over the Intranet or the Internet. This paper first provides an in-depth look of the standard arguments supported by ADO connection string; then gives the easier way for understanding the meaning, the utility and the syntax of the connection strings property on ADO connection object, and finally proposes solution to work around the problems due to the connection strings errors.

  8. Attribute-space connectivity and connected filters

    NARCIS (Netherlands)

    Wilkinson, Michael H.F.

    2007-01-01

    In this paper connected operators from mathematical morphology are extended to a wider class of operators, which are based on connectivities in higher dimensional spaces, similar to scale spaces, which will be called attribute-spaces. Though some properties of connected filters are lost, granulometr

  9. Undifferentiated Connective Tissue Disease

    Science.gov (United States)

    ... Home Conditions Undifferentiated Connective Tissue Disease (UCTD) Undifferentiated Connective Tissue Disease (UCTD) Make an Appointment Find a Doctor ... L. Goldstein, MD, MMSc (February 01, 2016) Undifferentiated connective tissue disease (UCTD) is a systemic autoimmune disease. This ...

  10. Connective Tissue Disorders

    Science.gov (United States)

    Connective tissue is the material inside your body that supports many of its parts. It is the "cellular ... their work. Cartilage and fat are examples of connective tissue. There are over 200 disorders that impact connective ...

  11. Minimum cost connection networks

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Tvede, Mich

    . We use three axioms to characterize allocation rules that truthfully implement cost minimizing networks satisfying all connection demands in a game where: (1) a central planner announces an allocation rule and a cost estimation rule; (2) every agent reports her own connection demand as well as all...... connection costs; and, (3) the central planner selects a cost minimizing network satisfying reported connection demands based on estimated connection costs and allocates true connection costs of the selected network....

  12. Automatic sequences

    CERN Document Server

    Haeseler, Friedrich

    2003-01-01

    Automatic sequences are sequences which are produced by a finite automaton. Although they are not random they may look as being random. They are complicated, in the sense of not being not ultimately periodic, they may look rather complicated, in the sense that it may not be easy to name the rule by which the sequence is generated, however there exists a rule which generates the sequence. The concept automatic sequences has special applications in algebra, number theory, finite automata and formal languages, combinatorics on words. The text deals with different aspects of automatic sequences, in particular:· a general introduction to automatic sequences· the basic (combinatorial) properties of automatic sequences· the algebraic approach to automatic sequences· geometric objects related to automatic sequences.

  13. Expressing stochastic filters via number sequences

    OpenAIRE

    Capponi, A.; Farina, A; Pilotto, C.

    2010-01-01

    We generalize the results presented in [1] regarding the relation between the Kalman filter and the Fibonacci sequence. We consider more general filtering models and relate the finite dimensional Kalman and Benes filters to the Fibonacci sequence and to the Golden Section. We also prove that Fibonacci numbers may be expressed as the convolution of the Fibonacci and Padovan sequence, thus extending the connection between stochastic filtering and Fibonacci sequence to the Padovan sequence.

  14. Controlled processing during sequencing

    Directory of Open Access Journals (Sweden)

    Malathi eThothathiri

    2015-10-01

    Full Text Available Longstanding evidence has identified a role for the frontal cortex in sequencing within both linguistic and non-linguistic domains. More recently, neuropsychological studies have suggested a specific role for the left premotor-prefrontal junction (BA 44/6 in selection between competing alternatives during sequencing. In this study, we used neuroimaging with healthy adults to confirm and extend knowledge about the neural correlates of sequencing. Participants reproduced visually presented sequences of syllables and words using manual button presses. Items in the sequence were presented either consecutively or concurrently. Concurrent presentation is known to trigger the planning of multiple responses, which might compete with one another. Therefore, we hypothesized that regions involved in controlled processing would show greater recruitment during the concurrent than the consecutive condition. Whole-brain analysis showed concurrent > consecutive activation in sensory, motor and somatosensory cortices and notably also in rostral-dorsal anterior cingulate cortex (ACC. Region of interest analyses showed increased activation within left BA 44/6 and correlation between this region’s activation and behavioral response times. Functional connectivity analysis revealed increased connectivity between left BA 44/6 and the posterior lobe of the cerebellum during the concurrent than the consecutive condition. These results corroborate recent evidence and demonstrate the involvement of BA 44/6 and other control regions when ordering co-activated representations.

  15. Controlled processing during sequencing.

    Science.gov (United States)

    Thothathiri, Malathi; Rattinger, Michelle

    2015-01-01

    Longstanding evidence has identified a role for the frontal cortex in sequencing within both linguistic and non-linguistic domains. More recently, neuropsychological studies have suggested a specific role for the left premotor-prefrontal junction (BA 44/6) in selection between competing alternatives during sequencing. In this study, we used neuroimaging with healthy adults to confirm and extend knowledge about the neural correlates of sequencing. Participants reproduced visually presented sequences of syllables and words using manual button presses. Items in the sequence were presented either consecutively or concurrently. Concurrent presentation is known to trigger the planning of multiple responses, which might compete with one another. Therefore, we hypothesized that regions involved in controlled processing would show greater recruitment during the concurrent than the consecutive condition. Whole-brain analysis showed concurrent > consecutive activation in sensory, motor and somatosensory cortices and notably also in rostral-dorsal anterior cingulate cortex. Region of interest analyses showed increased activation within left BA 44/6 and correlation between this region's activation and behavioral response times. Functional connectivity analysis revealed increased connectivity between left BA 44/6 and the posterior lobe of the cerebellum during the concurrent than the consecutive condition. These results corroborate recent evidence and demonstrate the involvement of BA 44/6 and other control regions when ordering co-activated representations.

  16. A Building Connecting Separated Communities

    DEFF Research Database (Denmark)

    Axel, Erik

    . in no systematic sequence. This, among other things, separates design and use, which is worth investigating in order to understand the problems involved in connecting the design of a house and analyzing the experience of a user. We undertook a preliminary investigation of how a dormitory for visiting students from...... with students from other dormitories, and connect with the Danes from other sections of the building isolating themselves. The janitor was surprised at the supposed function of the washing machines. Since other dormitories at the campus did not provide washing machines, the ones at the house investigated were...... in constant use, overloaded and noisy, making people stay away from the kitchen. With point of departure in this case, the nature of the spatial arrangements for the daily conduct of life are sketched out. The kitchen, hallways, washing machines and hotspots will be discussed as arrangements for accidental...

  17. Assembly design system based on engineering connection

    Science.gov (United States)

    Yin, Wensheng

    2016-12-01

    An assembly design system is an important part of computer-aided design systems, which are important tools for realizing product concept design. The traditional assembly design system does not record the connection information of production on the engineering layer; consequently, the upstream design idea cannot be fully used in the downstream design. An assembly design model based on the relationship of engineering connection is presented. In this model, all nodes are divided into two categories: The component and the connection. Moreover, the product is constructed on the basis of the connection relationship of the components. The model is an And/Or graph and has the ability to record all assembly schemes. This model records only the connection information that has engineering application value in the product design. In addition, this model can significantly reduce the number of combinations, and is very favorable for the assembly sequence planning in the downstream. The system contains a connection knowledge system that can be mapped to the connection node, and the connection knowledge obtained in practice can be returned to the knowledge system. Finally, VC++ 6.0 is used to develop a prototype system called Connect-based Assembly Planning (CAP). The relationship between the CAP system and the commercial assembly design system is also established.

  18. Asymptotically hyperbolic connections

    CERN Document Server

    Fine, Joel; Krasnov, Kirill; Scarinci, Carlos

    2015-01-01

    General Relativity in 4 dimensions can be equivalently described as a dynamical theory of SO(3)-connections rather than metrics. We introduce the notion of asymptotically hyperbolic connections, and work out an analog of the Fefferman-Graham expansion in the language of connections. As in the metric setup, one can solve the arising "evolution" equations order by order in the expansion in powers of the radial coordinate. The solution in the connection setting is arguably simpler, and very straightforward algebraic manipulations allow one to see how the obstruction appears at third order in the expansion. Another interesting feature of the connection formulation is that the "counter terms" required in the computation of the renormalised volume all combine into the Chern-Simons functional of the restriction of the connection to the boundary. As the Chern-Simons invariant is only defined modulo large gauge transformations, the requirement that the path integral over asymptotically hyperbolic connections is well-d...

  19. One Dimensional Locally Connected S-spaces

    CERN Document Server

    Kunen, Joan E Hart Kenneth

    2007-01-01

    We construct, assuming Jensen's principle diamond, a one-dimensional locally connected hereditarily separable continuum without convergent sequences. The construction is an inverse limit in omega_1 steps, and is patterned after the original Fedorchuk construction of a compact S-space. To make it one-dimensional, each space in the inverse limit is a copy of the Menger sponge.

  20. Eccentric connectivity index

    CERN Document Server

    Ilić, Aleksandar

    2011-01-01

    The eccentric connectivity index $\\xi^c$ is a novel distance--based molecular structure descriptor that was recently used for mathematical modeling of biological activities of diverse nature. It is defined as $\\xi^c (G) = \\sum_{v \\in V (G)} deg (v) \\cdot \\epsilon (v)$\\,, where $deg (v)$ and $\\epsilon (v)$ denote the vertex degree and eccentricity of $v$\\,, respectively. We survey some mathematical properties of this index and furthermore support the use of eccentric connectivity index as topological structure descriptor. We present the extremal trees and unicyclic graphs with maximum and minimum eccentric connectivity index subject to the certain graph constraints. Sharp lower and asymptotic upper bound for all graphs are given and various connections with other important graph invariants are established. In addition, we present explicit formulae for the values of eccentric connectivity index for several families of composite graphs and designed a linear algorithm for calculating the eccentric connectivity in...

  1. On eccentric connectivity index

    CERN Document Server

    Zhou, Bo

    2010-01-01

    The eccentric connectivity index, proposed by Sharma, Goswami and Madan, has been employed successfully for the development of numerous mathematical models for the prediction of biological activities of diverse nature. We now report mathematical properties of the eccentric connectivity index. We establish various lower and upper bounds for the eccentric connectivity index in terms of other graph invariants including the number of vertices, the number of edges, the degree distance and the first Zagreb index. We determine the n-vertex trees of diameter with the minimum eccentric connectivity index, and the n-vertex trees of pendent vertices, with the maximum eccentric connectivity index. We also determine the n-vertex trees with respectively the minimum, second-minimum and third-minimum, and the maximum, second-maximum and third-maximum eccentric connectivity indices for

  2. Sequence assembly

    DEFF Research Database (Denmark)

    Scheibye-Alsing, Karsten; Hoffmann, S.; Frankel, Annett Maria

    2009-01-01

    Despite the rapidly increasing number of sequenced and re-sequenced genomes, many issues regarding the computational assembly of large-scale sequencing data have remain unresolved. Computational assembly is crucial in large genome projects as well for the evolving high-throughput technologies and...... in genomic DNA, highly expressed genes and alternative transcripts in EST sequences. We summarize existing comparisons of different assemblers and provide a detailed descriptions and directions for download of assembly programs at: http://genome.ku.dk/resources/assembly/methods.html....

  3. Genome Sequencing

    DEFF Research Database (Denmark)

    Sato, Shusei; Andersen, Stig Uggerhøj

    2014-01-01

    The current Lotus japonicus reference genome sequence is based on a hybrid assembly of Sanger TAC/BAC, Sanger shotgun and Illumina shotgun sequencing data generated from the Miyakojima-MG20 accession. It covers nearly all expressed L. japonicus genes and has been annotated mainly based on transcr......The current Lotus japonicus reference genome sequence is based on a hybrid assembly of Sanger TAC/BAC, Sanger shotgun and Illumina shotgun sequencing data generated from the Miyakojima-MG20 accession. It covers nearly all expressed L. japonicus genes and has been annotated mainly based...

  4. Institutions for Asian Connectivity

    OpenAIRE

    Bhattacharyay, Biswa

    2010-01-01

    To make Asia more economically sustainable and resilient against external shocks, regional economies need to be rebalanced toward regional demand- and trade-driven growth through increased regional connectivity. The effectiveness of connectivity depends on the quality of hard and soft infrastructure. Of particular importance in terms of soft infrastructure which makes hard infrastructure work are the facilitating institutions that support connectivity through appropriate policies, reforms, sy...

  5. Handbook of networking & connectivity

    CERN Document Server

    McClain, Gary R

    1994-01-01

    Handbook of Networking & Connectivity focuses on connectivity standards in use, including hardware and software options. The book serves as a guide for solving specific problems that arise in designing and maintaining organizational networks.The selection first tackles open systems interconnection, guide to digital communications, and implementing TCP/IP in an SNA environment. Discussions focus on elimination of the SNA backbone, routing SNA over internets, connectionless versus connection-oriented networks, internet concepts, application program interfaces, basic principles of layering, proto

  6. 78 FR 55684 - ConnectED Workshop

    Science.gov (United States)

    2013-09-11

    ... content into the curriculum; and as classroom management software tools move everything from homework... consider promising strategies for achieving the President's goal of connecting virtually all K-12 students... policies and consider the most promising strategies for equipping K-12 schools for digital learning....

  7. Inverse Degree and Connectivity

    Institute of Scientific and Technical Information of China (English)

    MA Xiao-ling; TIAN Ying-zhi

    2013-01-01

    Let G be a connected graph with vertex set V(G),order n =丨V(G)丨,minimum degree δ(G) and connectivity κ(G).The graph G is called maximally connected if κ(G) =δ(G).Define the inverse degree of G with no isolated vertices as R(G) =Σv∈V(G)1/d(v),where d(v) denotes the degree of the vertex v.We show that G is maximally connected if R(G) < 1 + 2/δ + n-2δ+1/(n-1)(n-3).

  8. Asymptotically hyperbolic connections

    Science.gov (United States)

    Fine, Joel; Herfray, Yannick; Krasnov, Kirill; Scarinci, Carlos

    2016-09-01

    General relativity in four-dimensions can be equivalently described as a dynamical theory of {SO}(3)˜ {SU}(2)-connections rather than metrics. We introduce the notion of asymptotically hyperbolic connections, and work out an analogue of the Fefferman-Graham expansion in the language of connections. As in the metric setup, one can solve the arising ‘evolution’ equations order by order in the expansion in powers of the radial coordinate. The solution in the connection setting is arguably simpler, and very straightforward algebraic manipulations allow one to see how the unconstrained by Einstein equations ‘stress-energy tensor’ appears at third order in the expansion. Another interesting feature of the connection formulation is that the ‘counter terms’ required in the computation of the renormalised volume all combine into the Chern-Simons functional of the restriction of the connection to the boundary. As the Chern-Simons invariant is only defined modulo large gauge transformations, the requirement that the path integral over asymptotically hyperbolic connections is well-defined requires the cosmological constant to be quantised. Finally, in the connection setting one can deform the 4D Einstein condition in an interesting way, and we show that asymptotically hyperbolic connection expansion is universal and valid for any of the deformed theories.

  9. Minimum cost connection networks

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Tvede, Mich

    2015-01-01

    demands. We use a few axioms to characterize allocation rules that truthfully implement cost minimizing networks satisfying all connection demands in a game where: (1) a central planner announces an allocation rule and a cost estimation rule; (2) every agent reports her own connection demand as well...... as all connection costs; (3) the central planner selects a cost minimizing network satisfying reported connection demands based on the estimated costs; and, (4) the planner allocates the true costs of the selected network. It turns out that an allocation rule satisfies the axioms if and only if relative...

  10. Connecting Arithmetic to Algebra

    Science.gov (United States)

    Darley, Joy W.; Leapard, Barbara B.

    2010-01-01

    Algebraic thinking is a top priority in mathematics classrooms today. Because elementary school teachers lay the groundwork to develop students' capacity to think algebraically, it is crucial for teachers to have a conceptual understanding of the connections between arithmetic and algebra and be confident in communicating these connections. Many…

  11. Tokens of Connection

    Science.gov (United States)

    Crowley, Theresa

    2016-01-01

    When teachers make the effort to build a solid relationship with each student, built on trust, they often engender a life-long connection, one that's life-changing for the student. But how can teachers grow such long-lasting relationships with all students, especially disenfranchised learners and those who make it hard to connect? Crowley, a…

  12. Making Connections with Estimation.

    Science.gov (United States)

    Lobato, Joanne E.

    1993-01-01

    Describes four methods to structure estimation activities that enable students to make connections between their understanding of numbers and extensions of those concepts to estimating. Presents activities that connect estimation with other curricular areas, other mathematical topics, and real-world applications. (MDH)

  13. Generalized connectivity of graphs

    CERN Document Server

    Li, Xueliang

    2016-01-01

    Noteworthy results, proof techniques, open problems and conjectures in generalized (edge-) connectivity are discussed in this book. Both theoretical and practical analyses for generalized (edge-) connectivity of graphs are provided. Topics covered in this book include: generalized (edge-) connectivity of graph classes, algorithms, computational complexity, sharp bounds, Nordhaus-Gaddum-type results, maximum generalized local connectivity, extremal problems, random graphs, multigraphs, relations with the Steiner tree packing problem and generalizations of connectivity. This book enables graduate students to understand and master a segment of graph theory and combinatorial optimization. Researchers in graph theory, combinatorics, combinatorial optimization, probability, computer science, discrete algorithms, complexity analysis, network design, and the information transferring models will find this book useful in their studies.

  14. Handbook of Brain Connectivity

    CERN Document Server

    Jirsa, Viktor K

    2007-01-01

    Our contemporary understanding of brain function is deeply rooted in the ideas of the nonlinear dynamics of distributed networks. Cognition and motor coordination seem to arise from the interactions of local neuronal networks, which themselves are connected in large scales across the entire brain. The spatial architectures between various scales inevitably influence the dynamics of the brain and thereby its function. But how can we integrate brain connectivity amongst these structural and functional domains? Our Handbook provides an account of the current knowledge on the measurement, analysis and theory of the anatomical and functional connectivity of the brain. All contributors are leading experts in various fields concerning structural and functional brain connectivity. In the first part of the Handbook, the chapters focus on an introduction and discussion of the principles underlying connected neural systems. The second part introduces the currently available non-invasive technologies for measuring struct...

  15. Sequence-structure relations of biopolymers

    CERN Document Server

    Barrett, Christopher; Reidys, Christian M

    2015-01-01

    Motivation: DNA data is transcribed into single-stranded RNA, which folds into specific molecular structures. In this paper we pose the question to what extent sequence- and structure-information correlate. We view this correlation as structural semantics of sequence data that allows for a different interpretation than conventional sequence alignment. Structural semantics could enable us to identify more general embedded "patterns" in DNA and RNA sequences. Results: We compute the partition function of sequences with respect to a fixed structure and connect this computation to the mutual information of a sequence-structure pair for RNA secondary structures. We present a Boltzmann sampler and obtain the a priori probability of specific sequence patterns. We present a detailed analysis for the three PDB-structures, 2JXV (hairpin), 2N3R (3-branch multi-loop) and 1EHZ (tRNA). We localize specific sequence patterns, contrast the energy spectrum of the Boltzmann sampled sequences versus those sequences that refold ...

  16. On computing the nucleolus of a balanced connected game

    NARCIS (Netherlands)

    Solymosi, Tamás; Aarts, Harry; Driessen, Theo

    1998-01-01

    The question of “fairly” allocating costs or cost-savings among the participants of a joint enterprise is frequently answered by finding the nucleolus of a related cooperative game. In connection with various routing, sequencing and scheduling situations, connected games often arise. Their common fe

  17. Dna Sequencing

    Science.gov (United States)

    Tabor, Stanley; Richardson, Charles C.

    1995-04-25

    A method for sequencing a strand of DNA, including the steps off: providing the strand of DNA; annealing the strand with a primer able to hybridize to the strand to give an annealed mixture; incubating the mixture with four deoxyribonucleoside triphosphates, a DNA polymerase, and at least three deoxyribonucleoside triphosphates in different amounts, under conditions in favoring primer extension to form nucleic acid fragments complementory to the DNA to be sequenced; labelling the nucleic and fragments; separating them and determining the position of the deoxyribonucleoside triphosphates by differences in the intensity of the labels, thereby to determine the DNA sequence.

  18. Quantifying bicycle network connectivity.

    Science.gov (United States)

    Lowry, Michael; Loh, Tracy Hadden

    2017-02-01

    The intent of this study was to compare bicycle network connectivity for different types of bicyclists and different neighborhoods. Connectivity was defined as the ability to reach important destinations, such as grocery stores, banks, and elementary schools, via pathways or roads with low vehicle volumes and low speed limits. The analysis was conducted for 28 neighborhoods in Seattle, Washington under existing conditions and for a proposed bicycle master plan, which when complete will provide over 700 new bicycle facilities, including protected bike lanes, neighborhood greenways, and multi-use trails. The results showed different levels of connectivity across neighborhoods and for different types of bicyclists. Certain projects were shown to improve connectivity differently for confident and non-confident bicyclists. The analysis showed a positive correlation between connectivity and observed utilitarian bicycle trips. To improve connectivity for the majority of bicyclists, planners and policy-makers should provide bicycle facilities that allow immediate, low-stress access to the street network, such as neighborhood greenways. The analysis also suggests that policies and programs that build confidence for bicycling could greatly increase connectivity.

  19. Covariant Magnetic Connection Hypersurfaces

    CERN Document Server

    Pegoraro, F

    2016-01-01

    In the single fluid, nonrelativistic, ideal-Magnetohydrodynamic (MHD) plasma description magnetic field lines play a fundamental role by defining dynamically preserved "magnetic connections" between plasma elements. Here we show how the concept of magnetic connection needs to be generalized in the case of a relativistic MHD description where we require covariance under arbitrary Lorentz transformations. This is performed by defining 2-D {\\it magnetic connection hypersurfaces} in the 4-D Minkowski space. This generalization accounts for the loss of simultaneity between spatially separated events in different frames and is expected to provide a powerful insight into the 4-D geometry of electromagnetic fields when ${\\bf E} \\cdot {\\bf B} = 0$.

  20. Singularities of invariant connections

    Energy Technology Data Exchange (ETDEWEB)

    Amores, A.M. (Universidad Complutense, Madrid (Spain)); Gutierrez, M. (Universidad Politecnica, Madrid (Spain))

    1992-12-01

    A reductive homogeneous space M = P/G is considered, endowed with an invariant connection, i.e., such that all left translations of M induced by members of P preserve it. The authors study the set of singularities of such connections giving sufficient conditions for it to be empty, or, in other cases, familities of b-incomplete curves converging to singularities. A full description of the b-completion of a connection with M = R[sup m] (or a quotient of it) is given with information on its topology. 5 refs.

  1. Problem of Electromagnetoviscoelasticity for Multiply Connected Plates

    Science.gov (United States)

    Kaloerov, S. A.; Samodurov, A. A.

    2015-11-01

    A method for solving the problem of electromagnetoviscoelasticity for multiply connected plates is proposed. The small-parameter method is used to reduce this problem to a recursive sequence of problems of electromagnetoelasticity, which are solved by using complex potentials. A procedure is developed to determine, using complex potentials, approximations of the basic characteristics (stresses, electromagnetic-field strength, electromagnetic-flux density) of the electromagnetoelastic state at any time after application of a load. A plate with an elliptic hole is considered as an example. The variation in the electromagnetoelastic state of the multiply connected plate with time is studied

  2. Strengthening connections: functional connectivity and brain plasticity

    OpenAIRE

    2014-01-01

    The ascendancy of functional neuroimaging has facilitated the addition of network-based approaches to the neuropsychologist’s toolbox for evaluating the sequelae of brain insult. In particular, intrinsic functional connectivity (iFC) mapping of resting state fMRI (R-fMRI) data constitutes an ideal approach to measuring macro-scale networks in the human brain. Beyond the value of iFC mapping for charting how the functional topography of the brain is altered by insult and injury, iFC analyses c...

  3. Connective Tissue Naevus

    Directory of Open Access Journals (Sweden)

    Bhat Ramesh M

    1999-01-01

    Full Text Available A young adult female patient of connective tissue naevus presented with papules and indurated plaques on both les and left arm. Histopathology showed increased amount of collagen in the dermis. Osteopoikilosis was absent.

  4. Connective Tissue Disorder

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    2008349 A clinical analysis of 32 patients with diffuse alveolar hemorrhage in diffuse connective tissue diseases. CHEN Guangxing(陈光星), et al. Dept Rheumatol, PUMC & CAMS Beijing 100730. Chin J Intern Med 2008;47(5):362-365.Objective To provide clues to diagnosis and treatment for diffuse alveolar hemorrhage(DAH)in patients with diffuse connective tissue diseases(CTD).Method To analyze restropectively the data of clinical features,

  5. Reliability of power connections

    Institute of Scientific and Technical Information of China (English)

    BRAUNOVIC Milenko

    2007-01-01

    Despite the use of various preventive maintenance measures, there are still a number of problem areas that can adversely affect system reliability. Also, economical constraints have pushed the designs of power connections closer to the limits allowed by the existing standards. The major parameters influencing the reliability and life of Al-Al and Al-Cu connections are identified. The effectiveness of various palliative measures is determined and the misconceptions about their effectiveness are dealt in detail.

  6. NEACP Onboard Connectivity Study

    Science.gov (United States)

    1990-03-30

    Methodology Framework .............................. 6-3 6.2.2 Sources of ME Cost Savings with NOCH ............... 6-5 6.2.3 Additional Benefits of 1OCU...processing system (MPS) installation connects all record and data communications equipment to a common MIL -STD-1553B bus and automates many of the manual...Local Area Network Concepts A NOCH developed around a generic bus would provide connectivity throughout the aircraft, thereby reducing or eliminating

  7. Connections between Frontier Markets

    Directory of Open Access Journals (Sweden)

    Eliza-Olivia Lungu

    2013-06-01

    Full Text Available The global financial system presents a high degree of connectivity and the network theory provides the natural framework for visualizing the structure of it connections. I analyse the financial links established between the frontier markets and how these links evolve over a 10 years period (2001 - 2011. I identify patterns in the network looking both at the node specific statistics (degree, strength and clustering coefficient and at the aggregated network statistics (network density and network asymmetry index.

  8. [Connective tissue and inflammation].

    Science.gov (United States)

    Jakab, Lajos

    2014-03-23

    The author summarizes the structure of the connective tissues, the increasing motion of the constituents, which determine the role in establishing the structure and function of that. The structure and function of the connective tissue are related to each other in the resting as well as inflammatory states. It is emphasized that cellular events in the connective tissue are part of the defence of the organism, the localisation of the damage and, if possible, the maintenance of restitutio ad integrum. The organism responds to damage with inflammation, the non specific immune response, as well as specific, adaptive immunity. These processes are located in the connective tissue. Sterile and pathogenic inflammation are relatively similar processes, but inevitable differences are present, too. Sialic acids and glycoproteins containing sialic acids have important roles, and the role of Siglecs is also highlighted. Also, similarities and differences in damages caused by pathogens and sterile agents are briefly summarized. In addition, the roles of adhesion molecules linked to each other, and the whole event of inflammatory processes are presented. When considering practical consequences it is stressed that the structure (building up) of the organism and the defending function of inflammation both have fundamental importance. Inflammation has a crucial role in maintaining the integrity and the unimpaired somato-psychological state of the organism. Thus, inflammation serves as a tool of organism identical with the natural immune response, inseparably connected with the specific, adaptive immune response. The main events of the inflammatory processes take place in the connective tissue.

  9. A cooperative approach to sequencing and connection problems

    NARCIS (Netherlands)

    Ciftci, B.B.

    2009-01-01

    There are many economic settings in which a group of agents wishes to undertake a joint enterprise in order to save costs. The success of such enterprises often relies on agreements on how to share the cost savings generated. The central issue of this monograph is to address cost allocation problems

  10. Heritable Disorders of Connective Tissue

    Science.gov (United States)

    ... Connective Tissue Find a Clinical Trial Journal Articles Connective Tissue August 2016 Questions and Answers about Heritable Disorders of Connective Tissue This publication contains general information about heritable (genetic) ...

  11. Algebraic connectivity and graph robustness.

    Energy Technology Data Exchange (ETDEWEB)

    Feddema, John Todd; Byrne, Raymond Harry; Abdallah, Chaouki T. (University of New Mexico)

    2009-07-01

    Recent papers have used Fiedler's definition of algebraic connectivity to show that network robustness, as measured by node-connectivity and edge-connectivity, can be increased by increasing the algebraic connectivity of the network. By the definition of algebraic connectivity, the second smallest eigenvalue of the graph Laplacian is a lower bound on the node-connectivity. In this paper we show that for circular random lattice graphs and mesh graphs algebraic connectivity is a conservative lower bound, and that increases in algebraic connectivity actually correspond to a decrease in node-connectivity. This means that the networks are actually less robust with respect to node-connectivity as the algebraic connectivity increases. However, an increase in algebraic connectivity seems to correlate well with a decrease in the characteristic path length of these networks - which would result in quicker communication through the network. Applications of these results are then discussed for perimeter security.

  12. Linear connections on matrix geometries

    CERN Document Server

    Madore, J; Mourad, J; Madore, John; Masson, Thierry; Mourad, Jihad

    1994-01-01

    A general definition of a linear connection in noncommutative geometry has been recently proposed. Two examples are given of linear connections in noncommutative geometries which are based on matrix algebras. They both possess a unique metric connection.

  13. Connectable solar air collectors

    Energy Technology Data Exchange (ETDEWEB)

    Oestergaard Jensen, S.; Bosanac, M.

    2002-02-01

    The project has proved that it is possible to manufacture solar air collector panels, which in an easy way can be connected into large collector arrays with integrated ducting without loss of efficiency. The developed connectable solar air collectors are based on the use of matrix absorbers in the form of perforated metal sheets. Three interconnected solar air collectors of the above type - each with an transparent area of approx. 3 m{sup 2} - was tested and compared with parallel tests on two single solar air collectors also with a transparent area of approx. 3 m{sup 2} One of the single solar air collectors has an identical absorber as the connectable solar air collectors while the absorber of the other single solar air collector was a fibre cloth. The efficiency of the three solar air collectors proved to be almost identical in the investigated range of mass flow rates and temperature differences. The solar air collectors further proved to be very efficient - as efficient as the second most efficient solar air collectors tested in the IEA task 19 project Solar Air Systems. Some problems remain although to be solved: the pressure drop across especially the connectable solar air collectors is too high - mainly across the inlets of the solar air collectors. It should, however, be possible to considerably reduce the pressure losses with a more aerodynamic design of the inlet and outlet of the solar air collectors; The connectable solar air collectors are easy connectable but the air tightness of the connections in the present form is not good enough. As leakage leads to lower efficiencies focus should be put on making the connections more air tight without loosing the easiness in connecting the solar air collectors. As a spin off of the project a simple and easy way to determine the efficiency of solar, air collectors for pre-heating of fresh air has been validated. The simple method of determining the efficiency has with success been compared with an advance method

  14. Main: Sequences [KOME

    Lifescience Database Archive (English)

    Full Text Available Sequences Nucleotide Sequence Nucleotide sequence of full length cDNA (trimmed sequence) kome_ine_full_seq...uence_db.fasta.zip kome_ine_full_sequence_db.zip kome_ine_full_sequence_db ...

  15. The CONNECT project

    DEFF Research Database (Denmark)

    Assaf, Yaniv; Alexander, Daniel C; Jones, Derek K

    2013-01-01

    diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states. The CONNECT (Consortium......In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using...... tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal...

  16. Skeletal muscle connective tissue

    DEFF Research Database (Denmark)

    Brüggemann, Dagmar Adeline

      The connective tissue content of skeletal muscle is believed to be the major factor responsible for defining the eating quality of different meat cuts, although attempts to correlate quantifications based on traditional histological methods have not as yet been able to prove this relation....... Collagen, being the major protein in connective tissue, has been extensively investigated with regard to its relation to meat tenderness, but the results have been rather conflicting. Meat from older animals is tougher than that from younger animals, and changes in the properties of the collagen due...... that collagen plays a significant role in determining the tenderness of meat. What are we missing? Therefore, fundamental aspects of connective tissue research have been the centre of attention throughout this thesis. A holistic view has been applied, glancing at this complex tissue which has many facets...

  17. Connectivity and superconductivity

    CERN Document Server

    Rubinstein, Jacob

    2000-01-01

    The motto of connectivity and superconductivity is that the solutions of the Ginzburg--Landau equations are qualitatively influenced by the topology of the boundaries, as in multiply-connected samples. Special attention is paid to the "zero set", the set of the positions (also known as "quantum vortices") where the order parameter vanishes. The effects considered here usually become important in the regime where the coherence length is of the order of the dimensions of the sample. It takes the intuition of physicists and the awareness of mathematicians to find these new effects. In connectivity and superconductivity, theoretical and experimental physicists are brought together with pure and applied mathematicians to review these surprising results. This volume is intended to serve as a reference book for graduate students and researchers in physics or mathematics interested in superconductivity, or in the Schrödinger equation as a limiting case of the Ginzburg--Landau equations.

  18. Best connected rectangular arrangements

    Directory of Open Access Journals (Sweden)

    Krishnendra Shekhawat

    2016-03-01

    Full Text Available It can be found quite often in the literature that many well-known architects have employed either the golden rectangle or the Fibonacci rectangle in their works. On contrary, it is rare to find any specific reason for using them so often. Recently, Shekhawat (2015 proved that the golden rectangle and the Fibonacci rectangle are one of the best connected rectangular arrangements and this may be one of the reasons for their high presence in architectural designs. In this work we present an algorithm that generates n-4 best connected rectangular arrangements so that the proposed solutions can be further used by architects for their designs.

  19. Strengthening connections: functional connectivity and brain plasticity.

    Science.gov (United States)

    Kelly, Clare; Castellanos, F Xavier

    2014-03-01

    The ascendancy of functional neuroimaging has facilitated the addition of network-based approaches to the neuropsychologist's toolbox for evaluating the sequelae of brain insult. In particular, intrinsic functional connectivity (iFC) mapping of resting state fMRI (R-fMRI) data constitutes an ideal approach to measuring macro-scale networks in the human brain. Beyond the value of iFC mapping for charting how the functional topography of the brain is altered by insult and injury, iFC analyses can provide insights into experience-dependent plasticity at the macro level of large-scale functional networks. Such insights are foundational to the design of training and remediation interventions that will best facilitate recovery of function. In this review, we consider what is currently known about the origin and function of iFC in the brain, and how this knowledge is informative in neuropsychological settings. We then summarize studies that have examined experience-driven plasticity of iFC in healthy control participants, and frame these findings in terms of a schema that may aid in the interpretation of results and the generation of hypotheses for rehabilitative studies. Finally, we outline some caveats to the R-fMRI approach, as well as some current developments that are likely to bolster the utility of the iFC paradigm for neuropsychology.

  20. 18.CONNECTIVE TISSUE DISORDER

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    930734 Measurement of serum soluble interleukin—2 receptor in connective tissue diseases.CAI Houronget al.Dept Intern Med,Affili Gulou Hosp,Med School,Nanjing Univ,Nanjing,210008,ShanghaiJ Immunol 1993;13(4):216—218December 1993 Vol 10 No 4

  1. Connecting Competing Memories

    NARCIS (Netherlands)

    Laarse, van der R.; Saloul, I.A.M.

    Research Expert Meeting: Connecting Competing Memories of War in Contemporary Europe5 March 2014NIAS hosts, 6 - 7 March, the expert meeting of the Consortium for 'The Cultural Heritage of War in Contemporary Europe'. The aim is to draft main themes and discuss financial and research structures regar

  2. The Anansi Connection.

    Science.gov (United States)

    Carger, Chris Liska

    1998-01-01

    Describes a teacher educator's efforts to connect children's literature, sponsored by a partnership between Northern Illinois University and Chicago Public Schools. In one project, student teachers used award-winning picture books to inspire African-American eighth graders to create pastels on black paper. In another, regional folk tales inspired…

  3. Technology and Internet Connections.

    Science.gov (United States)

    Allen, Denise; Lindroth, Linda

    1996-01-01

    Suggests that teachers can use computer software and Internet connections to enhance curriculum and capitalize student's natural interest in sports and sports figures. Provides a list of activities that students can do in relation to the Olympic games and gives information on how technology can assist in such activities. Appropriate Internet…

  4. Wireless Connectivity and Capacity

    CERN Document Server

    Halldorsson, Magnus M

    2011-01-01

    Given $n$ wireless transceivers located in a plane, a fundamental problem in wireless communications is to construct a strongly connected digraph on them such that the constituent links can be scheduled in fewest possible time slots, assuming the SINR model of interference. In this paper, we provide an algorithm that connects an arbitrary point set in $O(\\log n)$ slots, improving on the previous best bound of $O(\\log^2 n)$ due to Moscibroda. This is complemented with a super-constant lower bound on our approach to connectivity. An important feature is that the algorithms allow for bi-directional (half-duplex) communication. One implication of this result is an improved bound of $\\Omega(1/\\log n)$ on the worst-case capacity of wireless networks, matching the best bound known for the extensively studied average-case. We explore the utility of oblivious power assignments, and show that essentially all such assignments result in a worst case bound of $\\Omega(n)$ slots for connectivity. This rules out a recent cla...

  5. Connecting with Your Audience.

    Science.gov (United States)

    Mamchur, Carolyn

    1989-01-01

    A workshop model on presentation skills for teachers in the classroom is presented. The goals and techniques would apply to many teaching situations in the college classroom, as well as lectures and symposium presentations. Making a personal connection, focusing on audience, and empowering the audience are discussed. (MLW)

  6. Clip, connect, clone

    DEFF Research Database (Denmark)

    Fujima, Jun; Lunzer, Aran; Hornbæk, Kasper

    2010-01-01

    using three mechanisms: clipping of input and result elements from existing applications to form cells on a spreadsheet; connecting these cells using formulas, thus enabling result transfer between applications; and cloning cells so that multiple requests can be handled side by side. We demonstrate...

  7. The connected brain

    NARCIS (Netherlands)

    van den Heuvel, M.P.

    2009-01-01

    The connected brain Martijn van den Heuvel, 2009 Our brain is a network. It is a network of different brain regions that are all functionally and structurally linked to each other. In the past decades, neuroimaging studies have provided a lot of information about the specific functions of each separ

  8. Preschool Connected Speech Inventory.

    Science.gov (United States)

    DiJohnson, Albert; And Others

    This speech inventory developed for a study of aurally handicapped preschool children (see TM 001 129) provides information on intonation patterns in connected speech. The inventory consists of a list of phrases and simple sentences accompanied by pictorial clues. The test is individually administered by a teacher-examiner who presents the spoken…

  9. Revisiting city connectivity

    NARCIS (Netherlands)

    Mans, U.

    2014-01-01

    This article introduces a new perspective on city connectivity in order to analyze non-hub cities and their position in the world economy. The author revisits the different approaches discussed in the Global Commodity Chains (GCC), Global Production Networks (GPN) and World City Network (WCN) discou

  10. Natural connections given by general linear and classical connections

    OpenAIRE

    Janyška, Josef

    2004-01-01

    We assume a vector bundle $p: E\\to M$ with a general linear connection $K$ and a classical linear connection $\\Lam$ on $M$. We prove that all classical linear connections on the total space $E$ naturally given by $(\\Lam, K)$ form a 15-parameter family. Further we prove that all connections on $J^1 E$ naturally given by $(\\Lam, K)$ form a 14-parameter family. Both families of connections are described geometrically.

  11. Network motifs in music sequences

    CERN Document Server

    Zanette, Damian H

    2010-01-01

    In this note, I summarize ongoing research on motif distribution in networks built up out of symbolic sequences of Western musical origin. Their motif significance profiles exhibit remarkable consistency over different styles and periods, and define a class that cannot be identified with any of the four "superfamilies" to which most real networks seem to belong. Networks from music sequences possess an unusual abundance of bidirectional connections, due to the inherent reversibility of short musical note patterns. This property contributes to motif significance from both local and large-scale features of musical structure.

  12. On contravariant product conjugate connections

    Directory of Open Access Journals (Sweden)

    A. M. Blaga

    2012-02-01

    Full Text Available Invariance properties for the covariant and contravariant connections on a Riemannian manifold with respect to an almost product structure are stated. Restricting to a distribution of the contravariant connections is also discussed. The particular case of the conjugate connection is investigated and properties of the extended structural and virtual tensors for the contravariant connections are given.

  13. An improved molecular connectivity index

    Institute of Scientific and Technical Information of China (English)

    李新华; 俞庆森; 朱龙观

    2000-01-01

    Through modification of the delta values of the molecular connectivity indexes, and connecting the quantum chemistry with topology method effectively, the molecular connectivity indexes are converted into quantum-topology indexes. The modified indexes not only keep all information obtained from the original molecular connectivity method but also have their own virtue in application, and at the same time make up some disadvantages of the quantum and molecular connectivity methods.

  14. From Sequence to Morphology - Long-Range Correlations in Complete Sequenced Genomes

    NARCIS (Netherlands)

    T.A. Knoch (Tobias)

    2004-01-01

    textabstractThe largely unresolved sequential organization, i.e. the relations within DNA sequences, and its connection to the three-dimensional organization of genomes was investigated by correlation analyses of completely sequenced chromosomes from Viroids, Archaea, Bacteria, Arabidopsis thali

  15. Connecting to Everyday Practices

    DEFF Research Database (Denmark)

    Iversen, Ole Sejer; Smith, Rachel Charlotte

    2012-01-01

    construction and reproduction of cultural heritage creating novel connections between self and others and between past, present and future. We present experiences from a current research project, the Digital Natives exhibition, in which social media was designed as an integral part of the exhibition to connect...... issues of digital heritage with audiences’ everyday practices in a museum. We point to the fact the use of social media in museums not only challenge us to rethink the design of technology for museum experiences. Social media also challenge us to rethink conceptions of museums and cultural heritage......We suggest that social media can contribute to reconnecting audiences’ everyday practices to issues of cultural heritage in museum institutions. Social media can support the creation of dialogical spaces in the museum, both playful and reflective, that allow audiences to engage in the ongoing...

  16. Connecting Science with Society

    DEFF Research Database (Denmark)

    awareness of the important questions of our society reflected in scientific research and of the answers produced by these research activities. The CRIS2010 conference, entitled “Bringing Science to Society”, therefore seeks to highlight the role of Current Research Information Systems for communicating......CRIS2010, the 10th conference in the bi-annual series organized by euroCRIS, focuses on the connecting role of Current Research Information Systems (CRIS). Aalborg, Denmark where CRIS2010 is held, is located near the intersection of the Northern Sea and Kattegat, a place were not only the waters...... of two seas are exchanged, but also goods and culture. In a similar way, Current Research Information Systems are at the intersection between (publicly funded) research and society. They do not only connect actors, activities and results within the research domain but also play a crucial role in raising...

  17. Weldless Flange Connections

    OpenAIRE

    Andersson, Mattias; Jonsson, Henrik; Löfqvist, Stefan; Maigne, Remi; Bravo, Unai

    2004-01-01

    This development project is a bachelor’s degree thesis work that will conclude the education program ”Development Technology” at Blekinge Institute of Technology. The development project has been done in cooperation with Faurecia Exhaust Systems AB in Torsås that constructs and manufactures manifolds, catalytic converters, mufflers and whole exhaust systems. The task with this project was to find a new solution concept for the connection of pipes into flanges in manifolds. The concept that Fa...

  18. Connecting with Citizens

    DEFF Research Database (Denmark)

    Jørgensen, Poul Erik Flyvholm; Isaksson, Maria

    2017-01-01

    /2007. If Norway, like Denmark, significantly reduces its number of municipalities, the majority of municipalities will undergo significant change and experience loss of identity. Each new municipality will need to create meaningful new identities attractive to publics fearful of alienation inside a community...... they have no relationship to. The study examines how municipalities reach out to connect with their publics, and whether they employ emotional and engaging discourse. Our data consists of 20 Norwegian and 20 Danish municipal websites....

  19. Energy storage connection system

    Science.gov (United States)

    Benedict, Eric L.; Borland, Nicholas P.; Dale, Magdelena; Freeman, Belvin; Kite, Kim A.; Petter, Jeffrey K.; Taylor, Brendan F.

    2012-07-03

    A power system for connecting a variable voltage power source, such as a power controller, with a plurality of energy storage devices, at least two of which have a different initial voltage than the output voltage of the variable voltage power source. The power system includes a controller that increases the output voltage of the variable voltage power source. When such output voltage is substantially equal to the initial voltage of a first one of the energy storage devices, the controller sends a signal that causes a switch to connect the variable voltage power source with the first one of the energy storage devices. The controller then causes the output voltage of the variable voltage power source to continue increasing. When the output voltage is substantially equal to the initial voltage of a second one of the energy storage devices, the controller sends a signal that causes a switch to connect the variable voltage power source with the second one of the energy storage devices.

  20. Connective tissue ulcers.

    Science.gov (United States)

    Dabiri, Ganary; Falanga, Vincent

    2013-11-01

    Connective tissue disorders (CTD), which are often also termed collagen vascular diseases, include a number of related inflammatory conditions. Some of these diseases include rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis (scleroderma), localized scleroderma (morphea variants localized to the skin), Sjogren's syndrome, dermatomyositis, polymyositis, and mixed connective tissue disease. In addition to the systemic manifestations of these diseases, there are a number of cutaneous features that make these conditions recognizable on physical exam. Lower extremity ulcers and digital ulcers are an infrequent but disabling complication of long-standing connective tissue disease. The exact frequency with which these ulcers occur is not known, and the cause of the ulcerations is often multifactorial. Moreover, a challenging component of CTD ulcerations is that there are still no established guidelines for their diagnosis and treatment. The morbidity associated with these ulcerations and their underlying conditions is very substantial. Indeed, these less common but intractable ulcers represent a major medical and economic problem for patients, physicians and nurses, and even well organized multidisciplinary wound healing centers.

  1. Recurrent Network Models of Sequence Generation and Memory.

    Science.gov (United States)

    Rajan, Kanaka; Harvey, Christopher D; Tank, David W

    2016-04-01

    Sequential activation of neurons is a common feature of network activity during a variety of behaviors, including working memory and decision making. Previous network models for sequences and memory emphasized specialized architectures in which a principled mechanism is pre-wired into their connectivity. Here we demonstrate that, starting from random connectivity and modifying a small fraction of connections, a largely disordered recurrent network can produce sequences and implement working memory efficiently. We use this process, called Partial In-Network Training (PINning), to model and match cellular resolution imaging data from the posterior parietal cortex during a virtual memory-guided two-alternative forced-choice task. Analysis of the connectivity reveals that sequences propagate by the cooperation between recurrent synaptic interactions and external inputs, rather than through feedforward or asymmetric connections. Together our results suggest that neural sequences may emerge through learning from largely unstructured network architectures.

  2. Connecting the Production Multiple

    DEFF Research Database (Denmark)

    Lichen, Alex Yu; Mouritsen, Jan

    was implementing sales and operations planning (S&OP) process to foster integration on its demand chain. Although actors wanted to see what it is to produce, that is to say, the object Production, as a singular object that could be diffused across time and space, Production became more multiple because the S...... in opposite directions. They are all part of the fluid object. There is no single chain of circulating references that makes the object a matter of fact. Accounting fluidity means that references drift back and forth and enact new realities also connected to the chain. In this setting future research may...

  3. Transcultural Tectonic Connections

    DEFF Research Database (Denmark)

    Carter, Adrian

    2014-01-01

    This paper presents an understanding of Jørn Utzon, as one of the most profound exponents of a transcultural and tectonic approach to modern architecture in the late twentieth century. The paper will examine the sources of inspiration, intersections and connections in Utzon’s architecture; which...... ruins in Mexico. The Sydney Opera House’s signature sail-like roof shells derive from knowledge of boat building in his youth and ancient Chinese and Japanese temple roofs floating above a stone base. With the choice of ceramic tiles to accentuate the sculptural character of the shells, owing its...

  4. Naturally Connecting the World

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ During China International Trade Fair for Home Textiles and Accessories held in Shanghai 2010(on Aug.25th the second day of the fair),Cotton Council International(CCI)hosted an exchange meeting targeted the COTTON USATM home textile licenses,taking"Naturally Connecting the World-Opportunities for Sourcing and Collaboration with Cotton-Made Home Textiles"as the theme of the meeting.CCI's representative institution in China invited the domestic famous home textile brands,enterprises and their customers to participate in the exchange which aims to introduce the current development trend of the global cotton textile industry through CCI,the powerful platform of communication.

  5. Practicing (Dis)connections

    DEFF Research Database (Denmark)

    day-to-day character of the work practices entailed, tracing their at once embedded, yet, distributed and disparate – (dis)connected – configurations. In the course of an MRI exam, from the screening of the patient to the scanning itself, and onto the subsequent processing and analysis of the images...... and redistribution of knowledge-practices in and through sociotechnical change, particularly in the light of the advent of film-less radiology, and how MRI comes to be particularly implicated in the transition/development in radiology toward practices entailing picture archive and communication systems (PACS...

  6. LHCb connects its pipes

    CERN Multimedia

    2006-01-01

    Two weeks ago the first beryllium section of the LHCb beam vacuum chamber was installed. This three-day operation, after requiring lengthy preparation work, demanded patience and precision as the first of four sections of the beampipe was connected to the vertex locator (VeLo) vacuum vessel. The AT-VAC Group with the collaboration of PH/LBD, including Gloria Corti, Tatsuya Nakada, Patrice Mermet, Delios Ramos, Frans Mul, Bruno Versollato, Bernard Corajod, and Raymond Veness. (Not pictured: Adriana Rossi and Laurent Bouvet) This first installed section is composed of a nearly two-metre long conical tube of one-millimetre thick beryllium and of a thin spherical-shaped window, 800 millimeter diameter, made of an aluminum alloy, and has the appearance of a mushroom lying on its side. The window is connected to the conical part of the beampipe through an aluminum alloy bellow, which is needed to allow for mechanical alignment once the assembly is installed. Beryllium was chosen as the material for 12 m of the 19...

  7. Transnational Connections and Multiple Belongings

    DEFF Research Database (Denmark)

    Galal, Lise Paulsen; Sparre, Sara Cathrine Lei

    With the purpose of presenting DIMECCE key findings, we in this paper present different aspects, potentials and challenges related to the Middle Eastern Christians transnational connections and multiple belonging. We distinguish between individual transnational connections and practices, such as ......, such as family relations, churches as transnational – or global – institutions, and other organisations and associations established to support politically, socially or culturally connections and development in the country or region of origin.......With the purpose of presenting DIMECCE key findings, we in this paper present different aspects, potentials and challenges related to the Middle Eastern Christians transnational connections and multiple belonging. We distinguish between individual transnational connections and practices...

  8. Poretools: a toolkit for analyzing nanopore sequence data

    OpenAIRE

    Loman, Nicholas J.; Quinlan, Aaron R.

    2014-01-01

    Motivation: Nanopore sequencing may be the next disruptive technology in genomics, owing to its ability to detect single DNA molecules without prior amplification, lack of reliance on expensive optical components, and the ability to sequence long fragments. The MinION™ from Oxford Nanopore Technologies (ONT) is the first nanopore sequencer to be commercialized and is now available to early-access users. The MinION™ is a USB-connected, portable nanopore sequencer that permits real-time analysi...

  9. Connect the future

    Institute of Scientific and Technical Information of China (English)

    李柯翰

    2015-01-01

    <正>China has been developed so rapidly that it economic strength grows fast like a rocket.It leads China to become the World’s second-largest economy.Because the change of our life conditions,more and more people are wiling to go abroad,in order to feel the fresh air,civilized language,advanced science,and harmony atmosphere,all of these things like baptism which shocked people’s heart.The pursuit of better life quality requires more and more important elements such as beautiful landscape,clean lake,elegant buildings,rigorous law and kind people,since the beauty of landscape depends on it’s quality,the prosperity of a country rely on it’s power.I’ve been dreaming to become a messenger who can establish connect between different countries and various people.

  10. The Connectivity Analysis of Intermittent Connected Wireless Network

    Institute of Scientific and Technical Information of China (English)

    Li Yun; Zhou Yahui; Liu Qilie; Wang Xiaoying

    2009-01-01

    The connectivity is a basic and important characteristic to the network, it expresses the situation of link connectivity directly, and provides important reference for the entire network plan. Using statistics and probability Theory, this article emphasizes the probability between any two nodes in the network which nodes are equally distributed and the connectivity of whole network. At last, this article has made verification through simulation and has made out a conclusion, the simulation result agrees with theoretical analysis.

  11. The Chitin Connection

    Science.gov (United States)

    Goldman, David L.; Vicencio, Alfin G.

    2012-01-01

    ABSTRACT Chitin, a polymer of N-acetylglucosamine, is an essential component of the fungal cell wall. Chitosan, a deacetylated form of chitin, is also important in maintaining cell wall integrity and is essential for Cryptococcus neoformans virulence. In their article, Gilbert et al. [N. M. Gilbert, L. G. Baker, C. A. Specht, and J. K. Lodge, mBio 3(1):e00007-12, 2012] demonstrate that the enzyme responsible for chitosan synthesis, chitin deacetylase (CDA), is differentially attached to the cell membrane and wall. Bioactivity is localized to the cell membrane, where it is covalently linked via a glycosylphosphatidylinositol (GPI) anchor. Findings from this study significantly enhance our understanding of cryptococcal cell wall biology. Besides the role of chitin in supporting structural stability, chitin and host enzymes with chitinase activity have an important role in host defense and modifying the inflammatory response. Thus, chitin appears to provide a link between the fungus and host that involves both innate and adaptive immune responses. Recently, there has been increased attention to the role of chitinases in the pathogenesis of allergic inflammation, especially asthma. We review these findings and explore the possible connection between fungal infections, the induction of chitinases, and asthma. PMID:22448043

  12. Formal connections in deformation quantization

    DEFF Research Database (Denmark)

    Masulli, Paolo

    attention on symplectic manifolds equipped with a family of star products, indexed by a parameter space. In this situation we can define a connection in the trivial bundle over the parameter space with fibres the formal smooth functions on the manifold, which relates the star products in the family...... and is called a formal connection. We study the question of classifying such formal connections. To each star product we can associate a certain cohomology class called the characteristic class. It turns out that a formal connection exists if and only if all the star products in the family have the same...... characteristic class, and that formal connections form an affine space over the derivations of the star products. Moreover, if the parameter space for the family of star products is contractible, we obtain that any two flat formal connections are gauge equivalent via a self-equivalence of the family of star...

  13. Hitchin's connection in metaplectic quantization

    DEFF Research Database (Denmark)

    Andersen, Jørgen Ellegaard; Gammelgaard, Niels Leth; Lauridsen, Magnus Roed

    2012-01-01

    We give a differential geometric construction of a connection, which we call the Hitchin connection, in the bundle of quantum Hilbert spaces arising from metaplectically corrected geometric quantization of a prequantizable, symplectic manifold, endowed with a rigid family of Kähler structures, all...... manifold in question. Furthermore, when we are in a setting similar to the moduli space, we give an explicit formula and show that this connection agrees with previous constructions....

  14. Interstate Connections - CEHC [ds619

    Data.gov (United States)

    California Department of Resources — The California Department of Transportation (Caltrans) and California Department of Fish and Game (CDFG) commissioned the California Essential Habitat Connectivity...

  15. Asymptotics of Lagged Fibonacci Sequences

    CERN Document Server

    Mertens, Stephan

    2009-01-01

    Consider "lagged" Fibonacci sequences $a(n) = a(n-1)+a(\\lfloor n/k\\rfloor)$ for $k > 1$. We show that $\\lim_{n\\to\\infty} a(kn)/a(n)\\cdot\\ln n/n = k\\ln k$ and we demonstrate the slow numerical convergence to this limit and how to deal with this slow convergence. We also discuss the connection between two classical results of N.G. de Bruijn and K. Mahler on the asymptotics of $a(n)$.

  16. Carl Sagan's Cosmic Connection

    Science.gov (United States)

    Sagan, Carl; Agel, Jerome

    2000-08-01

    Foreword Freeman Dyson; Personal reflections Ann Druyan; Preface; Part I. Cosmic Perspective: 1. A transitional animal; 2. The Unicorn of Cetus; 3. A message from earth; 4. A message to earth; 5. Experiments in utopias; 6. Chauvinism; 7. Space exploration as a human enterprise I. The scientific interest; 8. Space exploration as a human enterprise II. The public interest; 9. Space exploration as a human enterprise III. The historical interest; Part II. The Solar System: 10. On teaching the first grade; 11. 'The ancient and legendary Gods of old'; 12. The Venus detective story; 13. Venus is hell; 14. Science and 'intelligence'; 15. The moons of Barsoom; 16. The mountains of Mars I. Observations from earth; 17. The mountains of Mars II. Observations from space; 18. The canals of Mars; 19. The lost pictures of Mars; 20. The Ice Age and the cauldron; 21. Beginnings and ends of the Earth; 22. Terraforming the plants; 23. The exploration and utlization of the solar system; Part III. Beyond the Solar System: 24. Some of my best friends are dolphins; 25. 'Hello, central casting? Send me twenty extraterrestrials'; 26. The cosmic connection; 27. Extraterrestrial life: an idea whose time has come; 28. Has the Earth been visited?; 29. A search strategy for detecting extraterrestrial intelligence; 30. If we succeed 31. Cables, drums, and seashells; 32. The night freight to the stars; 33. Astroengineering; 34. Twenty questions: a classification of cosmic civilisations; 35. Galactic cultural exchanges; 36. A passage to elsewhere; 37. Starfolk I. A Fable; 38. Starfolk II. A future; 39. Starfolk III. The cosmic Cheshire cats; Epilog David Morrison; Index.

  17. Classifying Genomic Sequences by Sequence Feature Analysis

    Institute of Scientific and Technical Information of China (English)

    Zhi-Hua Liu; Dian Jiao; Xiao Sun

    2005-01-01

    Traditional sequence analysis depends on sequence alignment. In this study, we analyzed various functional regions of the human genome based on sequence features, including word frequency, dinucleotide relative abundance, and base-base correlation. We analyzed the human chromosome 22 and classified the upstream,exon, intron, downstream, and intergenic regions by principal component analysis and discriminant analysis of these features. The results show that we could classify the functional regions of genome based on sequence feature and discriminant analysis.

  18. Main: Sequences [KOME

    Lifescience Database Archive (English)

    Full Text Available Sequences Amino Acid Sequence Amino Acid sequence of full length cDNA (Longest ORF) kome_ine_full_seq...uence_amino_db.fasta.zip kome_ine_full_sequence_amino_db.zip kome_ine_full_sequence_amino_db ...

  19. Shotgun protein sequencing.

    Energy Technology Data Exchange (ETDEWEB)

    Faulon, Jean-Loup Michel; Heffelfinger, Grant S.

    2009-06-01

    A novel experimental and computational technique based on multiple enzymatic digestion of a protein or protein mixture that reconstructs protein sequences from sequences of overlapping peptides is described in this SAND report. This approach, analogous to shotgun sequencing of DNA, is to be used to sequence alternative spliced proteins, to identify post-translational modifications, and to sequence genetically engineered proteins.

  20. Financial Connections and Systemic Risk

    NARCIS (Netherlands)

    Allen, F.; Babus, A.; Carletti, E.

    2010-01-01

    We develop a model where institutions form connections through swaps of projects in order to diversify their individual risk. These connections lead to two different network structures. In a clustered network groups of financial institutions hold identical portfolios and default together. In an uncl

  1. [Muscles and connective tissue: histology].

    Science.gov (United States)

    Delage, J-P

    2012-10-01

    Here, we give some comments about the DVD movies "Muscle Attitudes" from Endovivo productions, the movies up lighting some loss in the attention given to studies on the connective tissue, and especially them into muscles. The main characteristics of the different components in the intra-muscular connective tissue (perimysium, endomysium, epimysium) are shown here with special references to their ordered architecture and special references to their spatial distributions. This connective tissue is abundant into the muscles and is in continuity with the muscles in vicinity, with their tendons and their sheath, sticking the whole on skin. This connective tissue has also very abundant connections on the muscles fibres. It is then assumed that the connective tissue sticks every organs or cells of the locomotion system. Considering the elastic properties of the collagen fibres which are the most abundant component of connective tissue, it is possible to up light a panel of connective tissue associated functions such as the transmission of muscle contractions or the regulation of protein and energetic muscles metabolism.

  2. Sequence Read Archive (SRA)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Sequence Read Archive (SRA) stores raw sequencing data from the next generation of sequencing platforms including Roche 454 GS System®, Illumina Genome...

  3. Multimodal sequence learning.

    Science.gov (United States)

    Kemény, Ferenc; Meier, Beat

    2016-02-01

    While sequence learning research models complex phenomena, previous studies have mostly focused on unimodal sequences. The goal of the current experiment is to put implicit sequence learning into a multimodal context: to test whether it can operate across different modalities. We used the Task Sequence Learning paradigm to test whether sequence learning varies across modalities, and whether participants are able to learn multimodal sequences. Our results show that implicit sequence learning is very similar regardless of the source modality. However, the presence of correlated task and response sequences was required for learning to take place. The experiment provides new evidence for implicit sequence learning of abstract conceptual representations. In general, the results suggest that correlated sequences are necessary for implicit sequence learning to occur. Moreover, they show that elements from different modalities can be automatically integrated into one unitary multimodal sequence.

  4. Hierarchies of Predominantly Connected Communities

    CERN Document Server

    Hamann, Michael; Wagner, Dorothea

    2013-01-01

    We consider communities whose vertices are predominantly connected, i.e., the vertices in each community are stronger connected to other community members of the same community than to vertices outside the community. Flake et al. introduced a hierarchical clustering algorithm that finds such predominantly connected communities of different coarseness depending on an input parameter. We present a simple and efficient method for constructing a clustering hierarchy according to Flake et al. that supersedes the necessity of choosing feasible parameter values and guarantees the completeness of the resulting hierarchy, i.e., the hierarchy contains all clusterings that can be constructed by the original algorithm for any parameter value. However, predominantly connected communities are not organized in a single hierarchy. Thus, we develop a framework that, after precomputing at most $2(n-1)$ maximum flows, admits a linear time construction of a clustering $\\C(S)$ of predominantly connected communities that contains ...

  5. Coordinate cytokine regulatory sequences

    Science.gov (United States)

    Frazer, Kelly A.; Rubin, Edward M.; Loots, Gabriela G.

    2005-05-10

    The present invention provides CNS sequences that regulate the cytokine gene expression, expression cassettes and vectors comprising or lacking the CNS sequences, host cells and non-human transgenic animals comprising the CNS sequences or lacking the CNS sequences. The present invention also provides methods for identifying compounds that modulate the functions of CNS sequences as well as methods for diagnosing defects in the CNS sequences of patients.

  6. Practical lessons in remote connectivity.

    Science.gov (United States)

    Kouroubali, A.; Starren, J.; Barrows, R. C.; Clayton, P. D.

    1997-01-01

    Community Health Information Networks (CHINs) require the ability to provide computer network connections to many remote sites. During the implementation of the Washington Heights and Inwood Community Health Management Information System (WHICHIS) at the Columbia-Presbyterian Medical Center (CPMC), a number of remote connectivity issues have been encountered. Both technical and non-technical issues were significant during the installation. We developed a work-flow model for this process which may be helpful to any health care institution attempting to provide seamless remote connectivity. This model is presented and implementation lessons are discussed. PMID:9357643

  7. Framework for Connections on Facebook

    DEFF Research Database (Denmark)

    Sudzina, Frantisek

    There is a substantial amount of current information systems and marketing research focused on social networking sites, most frequently on Facebook. Often, these studies utilize available metadata on user on-line behavior, such as what links the users clicked on. In order to better understand...... behavior of Facebook users, it makes sense to investigate also whom the users connect to. It is possible to hypothesize that behavior of people, who connect only to relatives on Facebook, differs from behavior of people, who are connected only to their classmates. The paper offers a framework of Facebook...

  8. Aromatic oligoamides with a rare ortho-connectivity

    DEFF Research Database (Denmark)

    Hjelmgaard, T.; Nielsen, John

    2013-01-01

    Even though aromatic oligoamides composed of aromatic amino acids in a "one-way sequence" attract ever increasing research interest, backbones connected through ortho-linked aromatics remain rare. Herein, we present the first synthesis and study of N-alkylated ortho-aminomethyl- benzamides termed...... studies indicated a more restricted rotation about the amide bonds in ortho-arylopeptoids, presumably due to a more congested backbone structure resulting from the ortho-connectivity pattern. Intriguingly, tert-butyl and phenyl side chains offer complete control over the amide conformations; whereas...

  9. Mundtlig eksamen via Adobe Connect

    DEFF Research Database (Denmark)

    Kjær, Christopher

    2011-01-01

    I løbet af de sidste tre år har der på Syddansk Universitet (SDU) været afholdt mere end 20 mundtlige kandidatforsvar samt andre mundtlige eksaminationer via webkonferencesystemet Adobe Connect. Formålet med denne artikel er at videregive de praktiske erfaringer fra gennemførelsen af disse...... eksaminationer samt at opstille nogle hensigtsmæssige retningslinjer for dem, der ønsker at give sig i kast med mundtlig eksamination via Adobe Connect. Der indledes derfor med en generel præsentation af Adobe Connect samt de elementer ved systemet, som oftest anvendes i forbindelse med mundtlig eksamination...... mundtlige eksaminationer via Adobe Connect....

  10. THE EXISTENCE OF CONNECTING ORBITS

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    In this paper,using the notion of an isolating block and Conley's attractor theory,an existence criterion of trajectories connecting a pair of invariant sets of ordinary differential equations is given.

  11. Connectivity threshold for Bluetooth graphs

    CERN Document Server

    Broutin, Nicolas; Fraiman, Nicolas; Lugosi, Gábor

    2011-01-01

    We study the connectivity properties of random Bluetooth graphs that model certain "ad hoc" wireless networks. The graphs are obtained as "irrigation subgraphs" of the well-known random geometric graph model. There are two parameters that control the model: the radius $r$ that determines the "visible neighbors" of each node and the number of edges $c$ that each node is allowed to send to these. The randomness comes from the underlying distribution of data points in space and from the choices of each vertex. We prove that no connectivity can take place with high probability for a range of parameters $r, c$ and completely characterize the connectivity threshold (in $c$) for values of $r$ close the critical value for connectivity in the underlying random geometric graph.

  12. [Connective tissue diseases in adolescents].

    Science.gov (United States)

    Peitz, J; Tantcheva-Poór, I

    2016-04-01

    In this article we provide a brief review of systemic lupus erythematosus, juvenile dermatomyositis, systemic scleroderma, and mixed connective tissue disease in adolescents. As skin manifestations often belong to the presenting symptoms and may have a significant impact on the quality of life, dermatologists play an important role in the management of patients with connective tissue diseases. Early diagnosis and therapy onset are crucial for the patients' long-term outcome.

  13. Symmetries in Connection Preserving Deformations

    Directory of Open Access Journals (Sweden)

    Christopher M. Ormerod

    2011-05-01

    Full Text Available e wish to show that the root lattice of Bäcklund transformations of the q-analogue of the third and fourth Painlevé equations, which is of type (A_2+A_1^{(1}, may be expressed as a quotient of the lattice of connection preserving deformations. Furthermore, we will show various directions in the lattice of connection preserving deformations present equivalent evolution equations under suitable transformations. These transformations correspond to the Dynkin diagram automorphisms.

  14. Network of tRNA Gene Sequences

    Institute of Scientific and Technical Information of China (English)

    WEI Fang-ping; LI Sheng; MA Hong-ru

    2008-01-01

    A network of 3719 tRNA gene sequences was constructed using simplest alignment. Its topology, degree distribution and clustering coefficient were studied. The behaviors of the network shift from fluctuated distribution to scale-free distribution when the similarity degree of the tRNA gene sequences increases. The tRNA gene sequences with the same anticodon identity are more self-organized than those with different anticodon identities and form local clusters in the network. Some vertices of the local cluster have a high connection with other local clusters, and the probable reason was given. Moreover, a network constructed by the same number of random tRNA sequences was used to make comparisons. The relationships between the properties of the tRNA similarity network and the characters of tRNA evolutionary history were discussed.

  15. Strongly 2-connected orientations of graphs

    DEFF Research Database (Denmark)

    Thomassen, Carsten

    2014-01-01

    We prove that a graph admits a strongly 2-connected orientation if and only if it is 4-edge-connected, and every vertex-deleted subgraph is 2-edge-connected. In particular, every 4-connected graph has such an orientation while no cubic 3-connected graph has such an orientation....

  16. Visualizing neuronal network connectivity with connectivity pattern tables

    Directory of Open Access Journals (Sweden)

    Eilen Nordlie

    2010-01-01

    Full Text Available Complex ideas are best conveyed through well-designed illustrations. Up to now, computational neuroscientists have mostly relied on box-and-arrow diagrams of even complex neuronal networks, often using ad hoc notations with conflicting use of symbols from paper to paper. This significantly impedes the communication of ideas in neuronal network modeling. We present here Connectivity Pattern Tables (CPTs as a clutter-free visualization of connectivity in large neuronal networks containing two-dimensional populations of neurons. CPTs can be generated automatically from the same script code used to create the actual network in the NEST simulator. Through aggregation, CPTs can be viewed at different levels, providing either full detail or summary information. We also provide the open source ConnPlotter tool as a means to create connectivity pattern tables.

  17. MedlinePlus Connect: Technical Information

    Science.gov (United States)

    ... You Are Here: Home → MedlinePlus Connect → Technical Information URL of this page: https://medlineplus.gov/connect/technical. ... on the How it Works page . Queries are URL-based. Connect uses the GET method not POST. ...

  18. Connect the dot: Computing feed-links for network extension

    Directory of Open Access Journals (Sweden)

    Boris Aronov

    2011-12-01

    Full Text Available Road network analysis can require distance from points that are not on the network themselves. We study the algorithmic problem of connecting a point inside a face (region of the road network to its boundary while minimizing the detour factor of that point to any point on the boundary of the face. We show that the optimal single connection (feed-link can be computed in O(lambda_7(n log n time, where n is the number of vertices that bounds the face and lambda_7(n is the slightly superlinear maximum length of a Davenport-Schinzel sequence of order 7 on n symbols. We also present approximation results for placing more feed-links, deal with the case that there are obstacles in the face of the road network that contains the point to be connected, and present various related results.

  19. Continuously Connected With Mobile IP

    Science.gov (United States)

    2002-01-01

    Cisco Systems developed Cisco Mobile Networks, making IP devices mobile. With this innovation, a Cisco router and its connected IP devices can roam across network boundaries and connection types. Because a mobile user is able to keep the same IP address while roaming, a live IP connection can be maintained without interruption. Glenn Research Center jointly tested the technology with Cisco, and is working to use it on low-earth-orbiting research craft. With Cisco's Mobile Networks functionality now available in Cisco IOS Software release 12.2(4)T, the commercial advantages and benefits are numerous. The technology can be applied to public safety, military/homeland security, emergency management services, railroad and shipping systems, and the automotive industry. It will allow ambulances, police, firemen, and the U.S. Coast Guard to stay connected to their networks while on the move. In the wireless battlefield, the technology will provide rapid infrastructure deployment for U.S. national defense. Airline, train, and cruise passengers utilizing Cisco Mobile Networks can fly all around the world with a continuous Internet connection. Cisco IOS(R) Software is a registered trademark of Cisco Systems.

  20. Genome Sequence Databases (Overview): Sequencing and Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Lapidus, Alla L.

    2009-01-01

    From the date its role in heredity was discovered, DNA has been generating interest among scientists from different fields of knowledge: physicists have studied the three dimensional structure of the DNA molecule, biologists tried to decode the secrets of life hidden within these long molecules, and technologists invent and improve methods of DNA analysis. The analysis of the nucleotide sequence of DNA occupies a special place among the methods developed. Thanks to the variety of sequencing technologies available, the process of decoding the sequence of genomic DNA (or whole genome sequencing) has become robust and inexpensive. Meanwhile the assembly of whole genome sequences remains a challenging task. In addition to the need to assemble millions of DNA fragments of different length (from 35 bp (Solexa) to 800 bp (Sanger)), great interest in analysis of microbial communities (metagenomes) of different complexities raises new problems and pushes some new requirements for sequence assembly tools to the forefront. The genome assembly process can be divided into two steps: draft assembly and assembly improvement (finishing). Despite the fact that automatically performed assembly (or draft assembly) is capable of covering up to 98% of the genome, in most cases, it still contains incorrectly assembled reads. The error rate of the consensus sequence produced at this stage is about 1/2000 bp. A finished genome represents the genome assembly of much higher accuracy (with no gaps or incorrectly assembled areas) and quality ({approx}1 error/10,000 bp), validated through a number of computer and laboratory experiments.

  1. Contamination of sequence databases with adaptor sequences

    Energy Technology Data Exchange (ETDEWEB)

    Yoshikawa, Takeo; Sanders, A.R.; Detera-Wadleigh, S.D. [National Institute of Mental Health, Bethesda, MD (United States)

    1997-02-01

    Because of the exponential increase in the amount of DNA sequences being added to the public databases on a daily basis, it has become imperative to identify sources of contamination rapidly. Previously, contaminations of sequence databases have been reported to alert the scientific community to the problem. These contaminations can be divided into two categories. The first category comprises host sequences that have been difficult for submitters to manage or control. Examples include anomalous sequences derived from Escherichia coli, which are inserted into the chromosomes (and plasmids) of the bacterial hosts. Insertion sequences are highly mobile and are capable of transposing themselves into plasmids during cloning manipulation. Another example of the first category is the infection with yeast genomic DNA or with bacterial DNA of some commercially available cDNA libraries from Clontech. The second category of database contamination is due to the inadvertent inclusion of nonhost sequences. This category includes incorporation of cloning-vector sequences and multicloning sites in the database submission. M13-derived artifacts have been common, since M13-based vectors have been widely used for subcloning DNA fragments. Recognizing this problem, the National Center for Biotechnology Information (NCBI) started to screen, in April 1994, all sequences directly submitted to GenBank, against a set of vector data retrieved from GenBank by use of key-word searches, such as {open_quotes}vector.{close_quotes} In this report, we present evidence for another sequence artifact that is widespread but that, to our knowledge, has not yet been reported. 11 refs., 1 tab.

  2. Automated DNA Sequencing System

    Energy Technology Data Exchange (ETDEWEB)

    Armstrong, G.A.; Ekkebus, C.P.; Hauser, L.J.; Kress, R.L.; Mural, R.J.

    1999-04-25

    Oak Ridge National Laboratory (ORNL) is developing a core DNA sequencing facility to support biological research endeavors at ORNL and to conduct basic sequencing automation research. This facility is novel because its development is based on existing standard biology laboratory equipment; thus, the development process is of interest to the many small laboratories trying to use automation to control costs and increase throughput. Before automation, biology Laboratory personnel purified DNA, completed cycle sequencing, and prepared 96-well sample plates with commercially available hardware designed specifically for each step in the process. Following purification and thermal cycling, an automated sequencing machine was used for the sequencing. A technician handled all movement of the 96-well sample plates between machines. To automate the process, ORNL is adding a CRS Robotics A- 465 arm, ABI 377 sequencing machine, automated centrifuge, automated refrigerator, and possibly an automated SpeedVac. The entire system will be integrated with one central controller that will direct each machine and the robot. The goal of this system is to completely automate the sequencing procedure from bacterial cell samples through ready-to-be-sequenced DNA and ultimately to completed sequence. The system will be flexible and will accommodate different chemistries than existing automated sequencing lines. The system will be expanded in the future to include colony picking and/or actual sequencing. This discrete event, DNA sequencing system will demonstrate that smaller sequencing labs can achieve cost-effective the laboratory grow.

  3. Supercomputers and biological sequence comparison algorithms.

    Science.gov (United States)

    Core, N G; Edmiston, E W; Saltz, J H; Smith, R M

    1989-12-01

    Comparison of biological (DNA or protein) sequences provides insight into molecular structure, function, and homology and is increasingly important as the available databases become larger and more numerous. One method of increasing the speed of the calculations is to perform them in parallel. We present the results of initial investigations using two dynamic programming algorithms on the Intel iPSC hypercube and the Connection Machine as well as an inexpensive, heuristically-based algorithm on the Encore Multimax.

  4. The solar-stellar connection

    Science.gov (United States)

    Giampapa, Mark S.

    2016-07-01

    A review of some principal results achieved in the area of stellar astrophysics with its origins in solar physics - the Solar-Stellar Connection - is presented from the perspective of an observational astronomer. The historical origins of the Solar-Stellar Connection are discussed followed by a review of key results from observations of stellar cycles analogous to the solar cycle in terms of parameters relevant to dynamo theory. A review of facets of angular momentum evolution and irradiance variations, each of which is determined by emergent, dynamo-generated magnetic fields, is given. Recent considerations of the impacts of stellar magnetic activity on the ambient radiative and energetic particle environment of the habitable zone of exoplanet systems are summarized. Some anticipated directions of the Solar-Stellar Connection in the new era of astronomy as defined by the advent of transformative facilities are presented.

  5. Pleura: In connective tissue diseases

    Directory of Open Access Journals (Sweden)

    Kaushik Saha

    2016-01-01

    Full Text Available Connective tissue diseases (CTDs (or collagen vascular diseases represent a heterogeneous group of immunologically mediated disorders that affects many organs of the body including pleura. Frequency, presentation, and prognosis of pleural involvement depend on the underlying CTD. Connective tissue disorders may be heritable such as Marfan syndrome, Ehlers-Danlos syndrome, and osteogenesis imperfecta; and autoimmune such as systemic lupus erythematosus (SLE, rheumatoid arthritis (RA, systemic sclerosis, mixed connective tissue disease (MCTD, Sjögren's syndrome (SS, dermatomyositis (DM, and polymyositis (PM. The subject of this review is to describe the variety of pleural disorders observed in the most frequent types of CTD: SLE, RA, scleroderma, SS, DM, PM, and MCTD.

  6. Intermodal Passenger Connectivity Database - Raw Data

    Data.gov (United States)

    Department of Transportation — The Intermodal Passenger Connectivity Database (IPCD) is a nationwide data table of passenger transportation terminals, with data on the availability of connections...

  7. Finding significantly connected voxels based on histograms of connection strengths

    DEFF Research Database (Denmark)

    Kasenburg, Niklas; Pedersen, Morten Vester; Darkner, Sune

    2016-01-01

    -distribution and significance is determined using the false discovery rate (FDR). Segmentations are based on significantly connected voxels and their FDR. In this work we focus on the thalamus and the target regions were chosen by dividing the cortex into a prefrontal/temporal zone, motor zone, somatosensory zone and a parieto...

  8. sequenceMiner algorithm

    Data.gov (United States)

    National Aeronautics and Space Administration — Detecting and describing anomalies in large repositories of discrete symbol sequences. sequenceMiner has been open-sourced! Download the file below to try it out....

  9. DNA sequencing conference, 2

    Energy Technology Data Exchange (ETDEWEB)

    Cook-Deegan, R.M. [Georgetown Univ., Kennedy Inst. of Ethics, Washington, DC (United States); Venter, J.C. [National Inst. of Neurological Disorders and Strokes, Bethesda, MD (United States); Gilbert, W. [Harvard Univ., Cambridge, MA (United States); Mulligan, J. [Stanford Univ., CA (United States); Mansfield, B.K. [Oak Ridge National Lab., TN (United States)

    1991-06-19

    This conference focused on DNA sequencing, genetic linkage mapping, physical mapping, informatics and bioethics. Several were used to study this sequencing and mapping. This article also discusses computer hardware and software aiding in the mapping of genes.

  10. Anomaly Detection in Sequences

    Data.gov (United States)

    National Aeronautics and Space Administration — We present a set of novel algorithms which we call sequenceMiner, that detect and characterize anomalies in large sets of high-dimensional symbol sequences that...

  11. Roles of repetitive sequences

    Energy Technology Data Exchange (ETDEWEB)

    Bell, G.I.

    1991-12-31

    The DNA of higher eukaryotes contains many repetitive sequences. The study of repetitive sequences is important, not only because many have important biological function, but also because they provide information on genome organization, evolution and dynamics. In this paper, I will first discuss some generic effects that repetitive sequences will have upon genome dynamics and evolution. In particular, it will be shown that repetitive sequences foster recombination among, and turnover of, the elements of a genome. I will then consider some examples of repetitive sequences, notably minisatellite sequences and telomere sequences as examples of tandem repeats, without and with respectively known function, and Alu sequences as an example of interspersed repeats. Some other examples will also be considered in less detail.

  12. Generalized connected domination in graphs

    Directory of Open Access Journals (Sweden)

    M. Kouider

    2006-01-01

    Full Text Available As a generalization of connected domination in a graph G we consider domination by sets having at most k components. The order γ c k (G of such a smallest set we relate to γ c (G, the order of a smallest connected dominating set. For a tree T we give bounds on γ c k (T in terms of minimum valency and diameter. For trees the inequality γ c k (T≤ n-k-1 is known to hold, we determine the class of trees, for which equality holds.

  13. Neural networks of colored sequence synesthesia.

    Science.gov (United States)

    Tomson, Steffie N; Narayan, Manjari; Allen, Genevera I; Eagleman, David M

    2013-08-28

    Synesthesia is a condition in which normal stimuli can trigger anomalous associations. In this study, we exploit synesthesia to understand how the synesthetic experience can be explained by subtle changes in network properties. Of the many forms of synesthesia, we focus on colored sequence synesthesia, a form in which colors are associated with overlearned sequences, such as numbers and letters (graphemes). Previous studies have characterized synesthesia using resting-state connectivity or stimulus-driven analyses, but it remains unclear how network properties change as synesthetes move from one condition to another. To address this gap, we used functional MRI in humans to identify grapheme-specific brain regions, thereby constructing a functional "synesthetic" network. We then explored functional connectivity of color and grapheme regions during a synesthesia-inducing fMRI paradigm involving rest, auditory grapheme stimulation, and audiovisual grapheme stimulation. Using Markov networks to represent direct relationships between regions, we found that synesthetes had more connections during rest and auditory conditions. We then expanded the network space to include 90 anatomical regions, revealing that synesthetes tightly cluster in visual regions, whereas controls cluster in parietal and frontal regions. Together, these results suggest that synesthetes have increased connectivity between grapheme and color regions, and that synesthetes use visual regions to a greater extent than controls when presented with dynamic grapheme stimulation. These data suggest that synesthesia is better characterized by studying global network dynamics than by individual properties of a single brain region.

  14. Enhanced virome sequencing using targeted sequence capture.

    Science.gov (United States)

    Wylie, Todd N; Wylie, Kristine M; Herter, Brandi N; Storch, Gregory A

    2015-12-01

    Metagenomic shotgun sequencing (MSS) is an important tool for characterizing viral populations. It is culture independent, requires no a priori knowledge of the viruses in the sample, and may provide useful genomic information. However, MSS can lack sensitivity and may yield insufficient data for detailed analysis. We have created a targeted sequence capture panel, ViroCap, designed to enrich nucleic acid from DNA and RNA viruses from 34 families that infect vertebrate hosts. A computational approach condensed ∼1 billion bp of viral reference sequence into <200 million bp of unique, representative sequence suitable for targeted sequence capture. We compared the effectiveness of detecting viruses in standard MSS versus MSS following targeted sequence capture. First, we analyzed two sets of samples, one derived from samples submitted to a diagnostic virology laboratory and one derived from samples collected in a study of fever in children. We detected 14 and 18 viruses in the two sets, comprising 19 genera from 10 families, with dramatic enhancement of genome representation following capture enrichment. The median fold-increases in percentage viral reads post-capture were 674 and 296. Median breadth of coverage increased from 2.1% to 83.2% post-capture in the first set and from 2.0% to 75.6% in the second set. Next, we analyzed samples containing a set of diverse anellovirus sequences and demonstrated that ViroCap could be used to detect viral sequences with up to 58% variation from the references used to select capture probes. ViroCap substantially enhances MSS for a comprehensive set of viruses and has utility for research and clinical applications.

  15. DNA sequences encoding erythropoietin

    Energy Technology Data Exchange (ETDEWEB)

    Lin, F.K.

    1987-10-27

    A purified and isolated DNA sequence is described consisting essentially of a DNA sequence encoding a polypeptide having an amino acid sequence sufficiently duplicative of that of erythropoietin to allow possession of the biological property of causing bone marrow cells to increase production of reticulocytes and red blood cells, and to increase hemoglobin synthesis or iron uptake.

  16. Critical Connections: Health and Academics

    Science.gov (United States)

    Michael, Shannon L.; Merlo, Caitlin L.; Basch, Charles E.; Wentzel, Kathryn R.; Wechsler, Howell

    2015-01-01

    Background: While it is a national priority to support the health and education of students, these sectors must better align, integrate, and collaborate to achieve this priority. This article summarizes the literature on the connection between health and academic achievement using the Whole School, Whole Community, and Whole Child (WSCC) framework…

  17. Indicators of malicious SSL connections

    NARCIS (Netherlands)

    Bortolameotti, R.; Peter, A.; Everts, M.H.; Bolzoni, D.

    2015-01-01

    Internet applications use SSL to provide data confidentiality to communicating entities. The use of encryption in SSL makes it impossible to distinguish between benign and malicious connections as the content cannot be inspected. Therefore, we propose and evaluate a set of indicators for malicious S

  18. Connecting the Dots: Rediscovering Continuity

    Science.gov (United States)

    Camenga, Kristin A.; Yates, Rebekah B. Johnson

    2014-01-01

    The topic of continuity is typically not introduced until calculus and then reexamined in real analysis. Recognizing the connections between secondary school mathematics and the advanced mathematics studied at the college level allows teachers to better identify mathematical concepts in student ideas, motivate students by piquing their curiosity,…

  19. Elementary Algebra Connections to Precalculus

    Science.gov (United States)

    Lopez-Boada, Roberto; Daire, Sandra Arguelles

    2013-01-01

    This article examines the attitudes of some precalculus students to solve trigonometric and logarithmic equations and systems using the concepts of elementary algebra. With the goal of enticing the students to search for and use connections among mathematical topics, they are asked to solve equations or systems specifically designed to allow…

  20. Grouted Connections with Shear Keys

    DEFF Research Database (Denmark)

    Pedersen, Ronnie; Jørgensen, M. B.; Damkilde, Lars

    2012-01-01

    This paper presents a finite element model in the software package ABAQUS in which a reliable analysis of grouted pile-to-sleeve connections with shear keys is the particular purpose. The model is calibrated to experimental results and a consistent set of input parameters is estimated so...

  1. The Reading/Writing Connection.

    Science.gov (United States)

    Anderson, Nancy Comfort

    1998-01-01

    Discusses ways to motivate children to become readers and writers, characteristics of good children's literature, using patterned books as models, and prewriting activities; provides an annotated bibliography of 26 patterned books to encourage the reading/writing connection. A subset of updated folk and fairy tales is included. (LRW)

  2. Connecting musicological tools with Europeana

    NARCIS (Netherlands)

    van Berchum, M.

    2015-01-01

    Within the Europeana Cloud project (see http://pro.europeana.eu/web/europeana- cloud) small research groups are engaged in the development of new research tools, connected to the content present in Europeana. In 2014 a group of musicologists working on early music subjects was invited to participate

  3. Low autocorrelation binary sequences

    Science.gov (United States)

    Packebusch, Tom; Mertens, Stephan

    2016-04-01

    Binary sequences with minimal autocorrelations have applications in communication engineering, mathematics and computer science. In statistical physics they appear as groundstates of the Bernasconi model. Finding these sequences is a notoriously hard problem, that so far can be solved only by exhaustive search. We review recent algorithms and present a new algorithm that finds optimal sequences of length N in time O(N {1.73}N). We computed all optimal sequences for N≤slant 66 and all optimal skewsymmetric sequences for N≤slant 119.

  4. Repdigits in -Lucas Sequences

    Indian Academy of Sciences (India)

    Jhon J J Bravo; Florian Luca

    2014-05-01

    For an integer ≥ 2, let $(L_n^{(k)})_n$ be the -Lucas sequence which starts with $0,\\ldots,0,2,1$ ( terms) and each term afterwards is the sum of the preceding terms. In 2000, Luca (Port. Math. 57(2) 2000 243-254) proved that 11 is the largest number with only one distinct digit (the so-called repdigit) in the sequence $(L_n^{(2)})_n$. In this paper, we address a similar problem in the family of -Lucas sequences. We also show that the -Lucas sequences have similar properties to those of -Fibonacci sequences and occur in formulae simultaneously with the latter.

  5. On Maximal Green Sequences

    CERN Document Server

    Brüstle, Thomas; Pérotin, Matthieu

    2012-01-01

    Maximal green sequences are particular sequences of quiver mutations which were introduced by Keller in the context of quantum dilogarithm identities and independently by Cecotti-Cordova-Vafa in the context of supersymmetric gauge theory. Our aim is to initiate a systematic study of these sequences from a combinatorial point of view. Interpreting maximal green sequences as paths in various natural posets arising in representation theory, we prove the finiteness of the number of maximal green sequences for cluster finite quivers, affine quivers and acyclic quivers with at most three vertices. We also give results concerning the possible numbers and lengths of these maximal green sequences. Finally we describe an algorithm for computing maximal green sequences for arbitrary valued quivers which we used to obtain numerous explicit examples that we present.

  6. On the Quality of Wireless Network Connectivity

    CERN Document Server

    Dasgupta, Soura

    2011-01-01

    Despite intensive research in the area of network connectivity, there is an important category of problems that remain unsolved: how to measure the quality of connectivity of a wireless multi-hop network which has a realistic number of nodes, not necessarily large enough to warrant the use of asymptotic analysis, and has unreliable connections, reflecting the inherent unreliable characteristics of wireless communications? The quality of connectivity measures how easily and reliably a packet sent by a node can reach another node. It complements the use of \\emph{capacity} to measure the quality of a network in saturated traffic scenarios and provides a native measure of the quality of (end-to-end) network connections. In this paper, we explore the use of probabilistic connectivity matrix as a possible tool to measure the quality of network connectivity. Some interesting properties of the probabilistic connectivity matrix and their connections to the quality of connectivity are demonstrated. We argue that the la...

  7. Introduction aux dynamiques cat\\'egoriques connectives

    CERN Document Server

    Dugowson, Stéphane

    2011-01-01

    This text is a continuation to my former article "On Connectivity Spaces". It takes into account that connectivity spaces gives rise to phenomena which are essentially dynamic. In a first stage, the representation of finite connectivity spaces by links (Brunn-Debrunner-Kanenobu's theorem) leads to the notion of connective representation. But examples of connective representations often come from dynamical systems. And this is even more obvious when we study the adjoint notion of connective foliation. To apply those notions to dynamics, we first need to consider dynamical systems in an unified way. This is done with a categorical point of view on temporalities and dynamics. It is then possible to define categorical connective dynamics, and to apply to them the various connective notions, specially the connectivity order of a connectivity space.

  8. Robot Sequencing and Visualization Program (RSVP)

    Science.gov (United States)

    Cooper, Brian K.; Maxwell,Scott A.; Hartman, Frank R.; Wright, John R.; Yen, Jeng; Toole, Nicholas T.; Gorjian, Zareh; Morrison, Jack C

    2013-01-01

    The Robot Sequencing and Visualization Program (RSVP) is being used in the Mars Science Laboratory (MSL) mission for downlink data visualization and command sequence generation. RSVP reads and writes downlink data products from the operations data server (ODS) and writes uplink data products to the ODS. The primary users of RSVP are members of the Rover Planner team (part of the Integrated Planning and Execution Team (IPE)), who use it to perform traversability/articulation analyses, take activity plan input from the Science and Mission Planning teams, and create a set of rover sequences to be sent to the rover every sol. The primary inputs to RSVP are downlink data products and activity plans in the ODS database. The primary outputs are command sequences to be placed in the ODS for further processing prior to uplink to each rover. RSVP is composed of two main subsystems. The first, called the Robot Sequence Editor (RoSE), understands the MSL activity and command dictionaries and takes care of converting incoming activity level inputs into command sequences. The Rover Planners use the RoSE component of RSVP to put together command sequences and to view and manage command level resources like time, power, temperature, etc. (via a transparent realtime connection to SEQGEN). The second component of RSVP is called HyperDrive, a set of high-fidelity computer graphics displays of the Martian surface in 3D and in stereo. The Rover Planners can explore the environment around the rover, create commands related to motion of all kinds, and see the simulated result of those commands via its underlying tight coupling with flight navigation, motor, and arm software. This software is the evolutionary replacement for the Rover Sequencing and Visualization software used to create command sequences (and visualize the Martian surface) for the Mars Exploration Rover mission.

  9. Constructing circuit codes by permuting initial sequences

    CERN Document Server

    Wynn, Ed

    2012-01-01

    Two new constructions are presented for coils and snakes in the hypercube. Improvements are made on the best known results for snake-in-the-box coils of dimensions 9, 10 and 11, and for some other circuit codes of dimensions between 8 and 13. In the first construction, circuit codes are generated from permuted copies of an initial transition sequence; the multiple copies constrain the search, so that long codes can be found relatively efficiently. In the second construction, two lower-dimensional paths are joined together with only one or two changes in the highest dimension; this requires a search for a permutation of the second sequence to fit around the first. It is possible to investigate sequences of vertices of the hypercube, including circuit codes, by connecting the corresponding vertices in an extended graph related to the hypercube. As an example of this, invertible circuit codes are briefly discussed.

  10. Adipokines in connective tissue diseases.

    Science.gov (United States)

    Sawicka, Karolina; Krasowska, Dorota

    2016-01-01

    Adipokines, pleiotropic molecules produced by white adipose tissue (WAT) have attracted the attention of scientists since 1994. The role of adipokines in metabolic syndrome is known and fixed. Adipokines exerting a variety of metabolic activities have contributed to the ethiopathogenesis and the consequences of metabolic syndrome. Furthermore, adipokines are involved in the regulation of inflammatory processes and autoimmunity in the light of pathogenesis of connective tissue diseases. Given some evidence for the influence of adipokines in metabolic syndrome, there may be a link between CVDs and rheumatic diseases. This review provides an overview of the literature focusing on the role of adipokines in rheumatic diseases by putting special emphasis on the potential role of leptin, resistin, adiponectin, chemerin, visfatin and novel adipokines in connective tissue diseases.

  11. Correlating thalamocortical connectivity and activity

    Science.gov (United States)

    da Fontoura Costa, Luciano; Sporns, Olaf

    2006-07-01

    The segregated regions of the mammalian cerebral cortex and thalamus form an extensive and complex network, whose structure and function are still only incompletely understood. The present letter describes an application of the concepts of complex networks and random walks that allows the identification of nonrandom, highly structured features of thalamocortical connections and their potential effects on dynamic interactions between cortical areas in the cat brain. Utilizing large-scale anatomical data sets of this thalamocortical system, we investigate uniform random walks in such a network by considering the steady state eigenvector of the respective stochastic matrix. It is shown that thalamocortical connections are organized in such a way as to guarantee strong correlation between the outdegree and occupancy rate (a stochastic measure potentially related to activation) of each cortical area. Possible organizational principles underlying this effect are identified and discussed.

  12. Toeplitz operators on connected domains

    Institute of Scientific and Technical Information of China (English)

    CAO; Guangfu

    2006-01-01

    The proof of the index formula of the Toeplitz operator with a continuous symbol on the Hardy space for the unit circle in the complex plane depends on the Hopftheorem. However,the analogue result of the Hopf theorem does not hold on a general connected domain. Hence,the extension of the index formula of the Toeplitz operator on a general domain needs a method which is different from that for the case of the unit circle. In the present paper, the index formula of the Toeplitz operator with a continuous symbol on the finite complex connected domain in the complex plane is obtained, and the cohomology groups of Toeplitz algebras on general domains are discussed. In addition, the Toeplitz operators with symbols in QC are also discussed.

  13. Connecting Remote Clusters with ATM

    Energy Technology Data Exchange (ETDEWEB)

    Hu, T.C.; Wyckoff, P.S.

    1998-10-01

    Sandia's entry into utilizing clusters of networked workstations is called Computational Plant or CPlant for short. The design of CPlant uses Ethernet to boot the individual nodes, Myrinet to communicate within a node cluster, and ATM to connect between remote clusters. This SAND document covers the work done to enable the use of ATM on the CPlant nodes in the Fall of 1997.

  14. Autoimmune Hepatitis and PSC Connection.

    Science.gov (United States)

    Vergani, Diego; Mieli-Vergani, Giorgina

    2008-02-01

    This article describes the connection between autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC). The two conditions have chronicity, liver inflammation, and a positive autoimmune serology in common; they differ in terms of gender distribution and bile duct damage. There is evidence suggesting that AIH and PSC are immune-mediated diseases. PSC and AIH could lie within the spectrum of the same disease process. Future studies should determine how frequently AIH evolves to PSC.

  15. The Cosmology - Particle Physics Connection

    OpenAIRE

    Trodden, Mark(Center for Particle Cosmology, Department of Physics & Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA 19104, United States)

    2006-01-01

    Modern cosmology poses deep and unavoidable questions for fundamental physics. In this plenary talk, delivered in slightly different forms at the {\\it Particles and Nuclei International Conference} (PANIC05) in Santa Fe, in October 2005, and at the {\\it CMB and Physics of the Early Universe International Conference}, on the island of Ischia, Italy, in April 2006, I discuss the broad connections between cosmology and particle physics, focusing on physics at the TeV scale, accessible at the nex...

  16. Connected Me - Proof of Concept

    OpenAIRE

    Vajravelu, Dilip Kumar

    2013-01-01

    Connected Me is a Human Body Communication (HBC) system, which is used fortransferring data through human body. The working principle is based on theorycalled Body Coupled Communication (BCC), which uses electrostatic couplingfor transferring data between device and human body. Capacitance between bodyand electrode acts as an electrical interface between devices. BCC has become aprominent research area in the field of Personal Area Network (PAN), introducedby Zimmerman in 1995. Until now ther...

  17. A test of the multiple connections model of reading acquisition.

    Science.gov (United States)

    Berninger, V W; Chen, A C; Abbott, R D

    1988-10-01

    Within the framework of Society of Mind Theory (Minsky, 1986), learning to read is conceptualized as a process of creating new communication links or neural connections between an existing visual society and an existing linguistic society. Four visual-linguistic connections may become functional: letter-phonemic code, whole word-semantic code, whole word-name code, letter sequence-aural syllabic code. The hypothesis was tested that more than one of these visual-linguistic connections must be taken into account in predicting reading achievement. Results showed that the combination of the composite letter-phoneme variable and the composite whole word-semantic code variable accounted for significantly more variance in oral reading than did either single variable at the end of the first grade. Groups with large absolute discrepancy (1 or more standard scores) or small absolute discrepancy (1/3 standard score or less) on corresponding visual and linguistic skills differed significantly in both oral (whole word-semantic code composite) and silent reading (whole word-semantic code and letter sequence-aural syllabic code composites). There was a relationship between the number of large discrepancies and reading achievement. Results are discussed in reference to neuropsychological models of connectionism (Rumelhart & McClelland, 1986) and working brain systems (Luria, 1973).

  18. On a nonorthogonal polynomial sequence associated with Bessel operator

    CERN Document Server

    Loureiro, Ana F; Yakubovich, S

    2011-01-01

    By means of the Bessel operator a polynomial sequence is constructed to which several properties are given. Among them, its explicit expression, the connection with the Euler numbers, its integral representation via the Kontorovich-Lebedev transform. Despite its non-orthogonality, it is possible to associate to the canonical element of its dual sequence a positive-definite measure as long as certain stronger constraints are imposed.

  19. Performance evaluations of demountable electrical connections

    Science.gov (United States)

    Niemann, R. C.; Cha, Y. S.; Hull, J. R.; Buckles, W. E.; Daugherty, M. A.

    Electrical conductors operating in cryogenic environments can require demountable connections along their lengths. The connections must have low resistance and high reliability and should allow ready assembly and disassembly. In this work, the performance of two types of connections has been evaluated. The first connection type is a clamped surface-to-surface joint. The second connection type is a screwed joint that incorporates male and female machine-thread components. The connections for copper conductors have been evaluated experimentally at 77 K. Experimental variables included thread surface treatment and assembly methods. The results of the evaluations are presented.

  20. Connectivity in Autism: A review of MRI connectivity studies

    Science.gov (United States)

    Rane, Pallavi; Cochran, David; Hodge, Steven M.; Haselgrove, Christian; Kennedy, David; Frazier, Jean A.

    2016-01-01

    Autism Spectrum Disorder (ASD) affects 1 in 50 children between the ages of 6–17 years as per a 2012 CDC survey of parents. The etiology of ASD is not precisely known. ASD is an umbrella term, which includes low (IQ70) individuals. A better understanding of the disorder, and how it manifests in an individual subject can lead to more effective intervention plans to fulfill the individual’s treatment needs. Magnetic resonance imaging (MRI) is a non-invasive investigational tool that can help study the ways in which the brain develops and/or deviates from the typical developmental trajectory. MRI offers insights into the structure, function, and metabolism of the brain. In this article, we review published studies on brain connectivity changes in ASD using either resting state functional MRI or diffusion tensor imaging. The general findings of decreases in white matter integrity and long-range neural coherence are prevalent in ASD literature. However, there is somewhat less of a consensus in the detailed localization of these findings. There are even fewer studies linking these connectivity alterations with the behavioral phenotype of the disorder. Nevertheless, with the help of data sharing and large-scale analytic efforts, the field is advancing towards several convergent themes. These include reduced functional coherence of long-range intra-hemispheric cortico-cortical default mode circuitry, impaired inter-hemispheric regulation, and an associated, perhaps compensatory, increase in local and short-range cortico-subcortical coherence. PMID:26146755

  1. Cosmetology: Scope and Sequence.

    Science.gov (United States)

    Nashville - Davidson County Metropolitan Public Schools, TN.

    This scope and sequence guide, developed for a cosmetology vocational education program, represents an initial step in the development of a systemwide articulated curriculum sequence for all vocational programs within the Metropolitan Nashville Public School System. It was developed as a result of needs expressed by teachers, parents, and the…

  2. DNA sequencing by CE.

    Science.gov (United States)

    Karger, Barry L; Guttman, András

    2009-06-01

    Sequencing of human and other genomes has been at the center of interest in the biomedical field over the past several decades and is now leading toward an era of personalized medicine. During this time, DNA-sequencing methods have evolved from the labor-intensive slab gel electrophoresis, through automated multiCE systems using fluorophore labeling with multispectral imaging, to the "next-generation" technologies of cyclic-array, hybridization based, nanopore and single molecule sequencing. Deciphering the genetic blueprint and follow-up confirmatory sequencing of Homo sapiens and other genomes were only possible with the advent of modern sequencing technologies that were a result of step-by-step advances with a contribution of academics, medical personnel and instrument companies. While next-generation sequencing is moving ahead at breakneck speed, the multicapillary electrophoretic systems played an essential role in the sequencing of the Human Genome, the foundation of the field of genomics. In this prospective, we wish to overview the role of CE in DNA sequencing based in part of several of our articles in this journal.

  3. Hardware bitstream sequence recognizer

    OpenAIRE

    Karpin, Oleksandr; Sokil, Volodymyr

    2009-01-01

    This paper describes how to implement in hardware a bistream sequence recognizer using the PSoC Pseudo Random Sequence Generator (PRS) User Module. The PRS can be used in digital communication systems with the serial data interface for automatic preamble detection and extraction, control words selection, etc.

  4. Sequencing the maize genome.

    Science.gov (United States)

    Martienssen, Robert A; Rabinowicz, Pablo D; O'Shaughnessy, Andrew; McCombie, W Richard

    2004-04-01

    Sequencing of complex genomes can be accomplished by enriching shotgun libraries for genes. In maize, gene-enrichment by copy-number normalization (high C(0)t) and methylation filtration (MF) have been used to generate up to two-fold coverage of the gene-space with less than 1 million sequencing reads. Simulations using sequenced bacterial artificial chromosome (BAC) clones predict that 5x coverage of gene-rich regions, accompanied by less than 1x coverage of subclones from BAC contigs, will generate high-quality mapped sequence that meets the needs of geneticists while accommodating unusually high levels of structural polymorphism. By sequencing several inbred strains, we propose a strategy for capturing this polymorphism to investigate hybrid vigor or heterosis.

  5. New molecular connections in angiogenesis

    Institute of Scientific and Technical Information of China (English)

    Qiling Xu; David Wilkinson

    2010-01-01

    @@ In vertebrates, oxygen and nutrients are delivered to tissues by the circula-tion of blood through vessels, comprised of a branched network of endothelial tubes termed the vasculature. Crucial for the formation of blood vessels during development is the process of angiogenesis, in which new sprouts form from pre-existing vessels in a complex cascade of cellular events. This involves the activation of an endothelial cell in the vessel to become a highly exploratory 'tip' cell that migrates to invade the surrounding tissues, while remaining tightly connected to the fol-lowing cells that subsequently generate the tubular structures of a new vessel.

  6. Content, Context & Connectivity Persuasive Interplay

    DEFF Research Database (Denmark)

    Sørensen, Christian Grund

    2013-01-01

    -supported research project under EACEA). In the development of this project several categories of content have been implemented in technology enhanced learning tools. These have been designed to support learning in different contexts and eventually the role of the connectivity of these learning objects and tools...... is discussed. Focus is here on The Kaj Munk Study Edition, The Conceptual Pond, Immersive Layers Design, and Generative Learning Objects (GLOs) which are applications affiliated with the Munk case. This paper explores the persuasive potential of the interplay between the different applications for the benefit...

  7. Connecting cognition and consumer choice.

    Science.gov (United States)

    Bartels, Daniel M; Johnson, Eric J

    2015-02-01

    We describe what can be gained from connecting cognition and consumer choice by discussing two contexts ripe for interaction between the two fields. The first-context effects on choice-has already been addressed by cognitive science yielding insights about cognitive process but there is promise for more interaction. The second is learning and representation in choice where relevant theories in cognitive science could be informed by consumer choice, and in return, could pose and answer new questions. We conclude by discussing how these two fields of research stand to benefit from more interaction, citing examples of how interfaces of cognitive science with other fields have been illuminating for theories of cognition.

  8. Connectivity graphs of uncertainty regions

    CERN Document Server

    Chambers, Erin; Lenchner, Jonathan; Sember, Jeff; Srinivasan, Venkatesh; Stege, Ulrike; Stolpner, Svetlana; Weibel, Christophe; Whitesides, Sue

    2010-01-01

    We study a generalization of the well known bottleneck spanning tree problem called "Best Case Connectivity with Uncertainty": Given a family of geometric regions, choose one point per region, such that the length of the longest edge in a spanning tree of a disc intersection graph is minimized. We show that this problem is NP-hard even for very simple scenarios such as line segments and squares. We also give exact and approximation algorithms for the case of line segments and unit discs respectively.

  9. The Cosmology - Particle Physics Connection

    CERN Document Server

    Trodden, M

    2006-01-01

    Modern cosmology poses deep and unavoidable questions for fundamental physics. In this plenary talk, delivered in slightly different forms at the {\\it Particles and Nuclei International Conference} (PANIC05) in Santa Fe, in October 2005, and at the {\\it CMB and Physics of the Early Universe International Conference}, on the island of Ischia, Italy, in April 2006, I discuss the broad connections between cosmology and particle physics, focusing on physics at the TeV scale, accessible at the next and future generations of colliders

  10. Collective action, clientelism and connectivity

    DEFF Research Database (Denmark)

    Shami, Mahvish

    are in short supply, the few that exist are generally pessimistic. This paper argues, however, that clientelist relations are highly context-specific, which matters a great deal for their implications for collective action. Making use of a natural experiment in rural Punjab, Pakistan, the paper finds...... that the unequal relationship between landlords and peasants does not, in and by itself, block peasant collective action. Rather, it is the interaction between clientelism and isolation that allow patrons to block community based projects. Despite still relying on powerful landlords, peasants in connected villages...

  11. Autoimmune connective tissue disease: scleroderma.

    Science.gov (United States)

    Wilson, Helen; Vincent, Rachel

    Scleroderma is an umbrella term for a spectrum of rare and complex autoimmune connective tissue diseases, the cause and pathogenesis of which is only partially defined. Scleroderma can be divided into two main subgroups--systemic and localized--but the hallmark of both is skin fibrosis. As yet no drug has been found to be effective in reversing the disease process, however early intervention has been shown to give maximum benefit. Due to the chronic nature of the condition a multidisciplinary approach is essential and the nurse's input from an early stage is vital in supporting the patient to manage both their medical treatment and their activities of daily living.

  12. Mathematical connections a capstone course

    CERN Document Server

    Conway, John B

    2010-01-01

    This book illustrates connections between various courses taken by undergraduate mathematics majors. As such it can be used as a text for a capstone course. The chapters are essentially independent, and the instructor can choose the topics that will form the course and thus tailor the syllabus to suit the backgrounds and abilities of the students. At the end of such a course the graduating seniors should glimpse mathematics not as a series of independent courses but as something more like an integrated body of knowledge. The book has numerous exercises and examples so that the student has many

  13. Evaluation measures of multiple sequence alignments.

    Science.gov (United States)

    Gonnet, G H; Korostensky, C; Benner, S

    2000-01-01

    Multiple sequence alignments (MSAs) are frequently used in the study of families of protein sequences or DNA/RNA sequences. They are a fundamental tool for the understanding of the structure, functionality and, ultimately, the evolution of proteins. A new algorithm, the Circular Sum (CS) method, is presented for formally evaluating the quality of an MSA. It is based on the use of a solution to the Traveling Salesman Problem, which identifies a circular tour through an evolutionary tree connecting the sequences in a protein family. With this approach, the calculation of an evolutionary tree and the errors that it would introduce can be avoided altogether. The algorithm gives an upper bound, the best score that can possibly be achieved by any MSA for a given set of protein sequences. Alternatively, if presented with a specific MSA, the algorithm provides a formal score for the MSA, which serves as an absolute measure of the quality of the MSA. The CS measure yields a direct connection between an MSA and the associated evolutionary tree. The measure can be used as a tool for evaluating different methods for producing MSAs. A brief example of the last application is provided. Because it weights all evolutionary events on a tree identically, but does not require the reconstruction of a tree, the CS algorithm has advantages over the frequently used sum-of-pairs measures for scoring MSAs, which weight some evolutionary events more strongly than others. Compared to other weighted sum-of-pairs measures, it has the advantage that no evolutionary tree must be constructed, because we can find a circular tour without knowing the tree.

  14. RIKEN Integrated Sequence Analysis (RISA) System—384-Format Sequencing Pipeline with 384 Multicapillary Sequencer

    OpenAIRE

    Shibata, Kazuhiro; Itoh, Masayoshi; Aizawa, Katsunori; Nagaoka, Sumiharu; Sasaki, Nobuya; Carninci, Piero; Konno, Hideaki; AKIYAMA, Junichi; Nishi, Katsuo; Kitsunai, Tokuji; Tashiro, Hideo; Itoh, Mari; Sumi, Noriko; Ishii, Yoshiyuki; Nakamura, Shin

    2000-01-01

    The RIKEN high-throughput 384-format sequencing pipeline (RISA system) including a 384-multicapillary sequencer (the so-called RISA sequencer) was developed for the RIKEN mouse encyclopedia project. The RISA system consists of colony picking, template preparation, sequencing reaction, and the sequencing process. A novel high-throughput 384-format capillary sequencer system (RISA sequencer system) was developed for the sequencing process. This system consists of a 384-multicapillary auto seque...

  15. MOHCS: Towards Mining Overlapping Highly Connected Subgraphs

    CERN Document Server

    Lin, Xiahong; Chen, Kefei; Chiu, David K Y

    2008-01-01

    Many networks in real-life typically contain parts in which some nodes are more highly connected to each other than the other nodes of the network. The collection of such nodes are usually called clusters, communities, cohesive groups or modules. In graph terminology, it is called highly connected graph. In this paper, we first prove some properties related to highly connected graph. Based on these properties, we then redefine the highly connected subgraph which results in an algorithm that determines whether a given graph is highly connected in linear time. Then we present a computationally efficient algorithm, called MOHCS, for mining overlapping highly connected subgraphs. We have evaluated experimentally the performance of MOHCS using real and synthetic data sets from computer-generated graph and yeast protein network. Our results show that MOHCS is effective and reliable in finding overlapping highly connected subgraphs. Keywords-component; Highly connected subgraph, clustering algorithms, minimum cut, m...

  16. Linear connections on the quantum plane

    CERN Document Server

    Dubois-Violette, M; Masson, T; Mourad, J; Dubois-Violette, Michel; Madore, John; Masson, Thierry; Mourad, Jihad

    1994-01-01

    A general definition has been proposed recently of a linear connection and a metric in noncommutative geometry. It is shown that to within normalization there is a unique linear connection on the quantum plane and there is no metric.

  17. Understanding and Connections between Equations and Graphs.

    Science.gov (United States)

    Knuth, Eric J.

    2000-01-01

    Presents results from a study that examined students' understanding of connections between algebraic and graphical representations of functions. Discusses a possible reason for the inadequate and often absent connections that students made between them. (ASK)

  18. Neural network connectivity and response latency modelled by stochastic processes

    DEFF Research Database (Denmark)

    Tamborrino, Massimiliano

    is connected to thousands of other neurons. The rst question is: how to model neural networks through stochastic processes? A multivariate Ornstein-Uhlenbeck process, obtained as a diffusion approximation of a jump process, is the proposed answer. Obviously, dependencies between neurons imply dependencies......Stochastic processes and their rst passage times have been widely used to describe the membrane potential dynamics of single neurons and to reproduce neuronal spikes, respectively.However, cerebral cortex in human brains is estimated to contain 10-20 billions of neurons and each of them...... between their spike times. Therefore, the second question is: how to detect neural network connectivity from simultaneously recorded spike trains? Answering this question corresponds to investigate the joint distribution of sequences of rst passage times. A non-parametric method based on copulas...

  19. Embedded adhesive connection for laminated glass plates

    DEFF Research Database (Denmark)

    Hansen, Jens Zangenberg; Poulsen, S.H.; Bagger, A.

    2012-01-01

    The structural behavior of a new connection design, the embedded adhesive connection, used for laminated glass plates is investigated. The connection consists of an aluminum plate encapsulated in-between two adjacent triple layered laminated glass plates. Fastening between glass and aluminum...... usage in a design situation. The embedded connection shows promising potential as a future fastening system for load-carrying laminated glass plates....

  20. Affine connections on involutive G-structures

    OpenAIRE

    Merkulov, Sergey A.

    1995-01-01

    This paper is a review of the twistor theory of irreducible G-structures and affine connections. Long ago, Berger presented a very restricted list of possible irreducibly acting holonomies of torsion-free affine connections. His list was complete in the part of metric connections, while the situation with holonomies of non-metric torsion-free affine connections was and remains rather unclear. One of the results discussed in this review asserts that any torsion-free holomorphic affine connecti...

  1. Connectivity editing for quadrilateral meshes

    KAUST Repository

    Peng, Chihan

    2011-12-01

    We propose new connectivity editing operations for quadrilateral meshes with the unique ability to explicitly control the location, orientation, type, and number of the irregular vertices (valence not equal to four) in the mesh while preserving sharp edges. We provide theoretical analysis on what editing operations are possible and impossible and introduce three fundamental operations to move and re-orient a pair of irregular vertices. We argue that our editing operations are fundamental, because they only change the quad mesh in the smallest possible region and involve the fewest irregular vertices (i.e., two). The irregular vertex movement operations are supplemented by operations for the splitting, merging, canceling, and aligning of irregular vertices. We explain how the proposed high-level operations are realized through graph-level editing operations such as quad collapses, edge flips, and edge splits. The utility of these mesh editing operations are demonstrated by improving the connectivity of quad meshes generated from state-of-art quadrangulation techniques.

  2. Connectivity editing for quadrilateral meshes

    KAUST Repository

    Peng, Chihan

    2011-12-12

    We propose new connectivity editing operations for quadrilateral meshes with the unique ability to explicitly control the location, orientation, type, and number of the irregular vertices (valence not equal to four) in the mesh while preserving sharp edges. We provide theoretical analysis on what editing operations are possible and impossible and introduce three fundamental operations to move and re-orient a pair of irregular vertices. We argue that our editing operations are fundamental, because they only change the quad mesh in the smallest possible region and involve the fewest irregular vertices (i.e., two). The irregular vertex movement operations are supplemented by operations for the splitting, merging, canceling, and aligning of irregular vertices. We explain how the proposed highlevel operations are realized through graph-level editing operations such as quad collapses, edge flips, and edge splits. The utility of these mesh editing operations are demonstrated by improving the connectivity of quad meshes generated from state-of-art quadrangulation techniques. © 2011 ACM.

  3. Astrophysicists' conversational connections on Twitter.

    Science.gov (United States)

    Holmberg, Kim; Bowman, Timothy D; Haustein, Stefanie; Peters, Isabella

    2014-01-01

    Because Twitter and other social media are increasingly used for analyses based on altmetrics, this research sought to understand what contexts, affordance use, and social activities influence the tweeting behavior of astrophysicists. Thus, the presented study has been guided by three research questions that consider the influence of astrophysicists' activities (i.e., publishing and tweeting frequency) and of their tweet construction and affordance use (i.e. use of hashtags, language, and emotions) on the conversational connections they have on Twitter. We found that astrophysicists communicate with a variety of user types (e.g. colleagues, science communicators, other researchers, and educators) and that in the ego networks of the astrophysicists clear groups consisting of users with different professional roles can be distinguished. Interestingly, the analysis of noun phrases and hashtags showed that when the astrophysicists address the different groups of very different professional composition they use very similar terminology, but that they do not talk to each other (i.e. mentioning other user names in tweets). The results also showed that in those areas of the ego networks that tweeted more the sentiment of the tweets tended to be closer to neutral, connecting frequent tweeting with information sharing activities rather than conversations or expressing opinions.

  4. Astrophysicists' conversational connections on Twitter.

    Directory of Open Access Journals (Sweden)

    Kim Holmberg

    Full Text Available Because Twitter and other social media are increasingly used for analyses based on altmetrics, this research sought to understand what contexts, affordance use, and social activities influence the tweeting behavior of astrophysicists. Thus, the presented study has been guided by three research questions that consider the influence of astrophysicists' activities (i.e., publishing and tweeting frequency and of their tweet construction and affordance use (i.e. use of hashtags, language, and emotions on the conversational connections they have on Twitter. We found that astrophysicists communicate with a variety of user types (e.g. colleagues, science communicators, other researchers, and educators and that in the ego networks of the astrophysicists clear groups consisting of users with different professional roles can be distinguished. Interestingly, the analysis of noun phrases and hashtags showed that when the astrophysicists address the different groups of very different professional composition they use very similar terminology, but that they do not talk to each other (i.e. mentioning other user names in tweets. The results also showed that in those areas of the ego networks that tweeted more the sentiment of the tweets tended to be closer to neutral, connecting frequent tweeting with information sharing activities rather than conversations or expressing opinions.

  5. HIV Sequence Compendium 2015

    Energy Technology Data Exchange (ETDEWEB)

    Foley, Brian Thomas [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Leitner, Thomas Kenneth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Apetrei, Cristian [Univ. of Pittsburgh, PA (United States); Hahn, Beatrice [Univ. of Pennsylvania, Philadelphia, PA (United States); Mizrachi, Ilene [National Center for Biotechnology Information, Bethesda, MD (United States); Mullins, James [Univ. of Washington, Seattle, WA (United States); Rambaut, Andrew [Univ. of Edinburgh, Scotland (United Kingdom); Wolinsky, Steven [Northwestern Univ., Evanston, IL (United States); Korber, Bette Tina Marie [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-10-05

    This compendium is an annual printed summary of the data contained in the HIV sequence database. We try to present a judicious selection of the data in such a way that it is of maximum utility to HIV researchers. Each of the alignments attempts to display the genetic variability within the different species, groups and subtypes of the virus. This compendium contains sequences published before January 1, 2015. Hence, though it is published in 2015 and called the 2015 Compendium, its contents correspond to the 2014 curated alignments on our website. The number of sequences in the HIV database is still increasing. In total, at the end of 2014, there were 624,121 sequences in the HIV Sequence Database, an increase of 7% since the previous year. This is the first year that the number of new sequences added to the database has decreased compared to the previous year. The number of near complete genomes (>7000 nucleotides) increased to 5834 by end of 2014. However, as in previous years, the compendium alignments contain only a fraction of these. A more complete version of all alignments is available on our website, http://www.hiv.lanl.gov/ content/sequence/NEWALIGN/align.html As always, we are open to complaints and suggestions for improvement. Inquiries and comments regarding the compendium should be addressed to seq-info@lanl.gov.

  6. Book Review: Infrastructure for Asian Connectivity

    OpenAIRE

    Sandee, Henry

    2013-01-01

    This article reviews the book Infrastructure for Asian Connectivity edited by Bhattacharyay, Kawai and Nag (2012). This book is the second publication coordinated by the ADB and the ADB Institute focusing on infrastructure and connectivity in Asian countries. This book looks at regional (across border) infrastructure that is needed to facilitate growth and development through better connectivity and integration among countries.

  7. MedlinePlus Connect: Web Service

    Science.gov (United States)

    ... MedlinePlus Connect → Web Service URL of this page: https://medlineplus.gov/connect/service.html MedlinePlus Connect: Web ... the base URL for the Web service is: https://apps.nlm.nih.gov/medlineplus/services/mpconnect_service. ...

  8. MedlinePlus Connect: Web Application

    Science.gov (United States)

    ... MedlinePlus Connect → Web Application URL of this page: https://medlineplus.gov/connect/application.html MedlinePlus Connect: Web ... the base URL for the Web application is: https://apps.nlm.nih.gov/medlineplus/services/mpconnect.cfm ...

  9. Phylogenetic Trees From Sequences

    Science.gov (United States)

    Ryvkin, Paul; Wang, Li-San

    In this chapter, we review important concepts and approaches for phylogeny reconstruction from sequence data.We first cover some basic definitions and properties of phylogenetics, and briefly explain how scientists model sequence evolution and measure sequence divergence. We then discuss three major approaches for phylogenetic reconstruction: distance-based phylogenetic reconstruction, maximum parsimony, and maximum likelihood. In the third part of the chapter, we review how multiple phylogenies are compared by consensus methods and how to assess confidence using bootstrapping. At the end of the chapter are two sections that list popular software packages and additional reading.

  10. Impact of Negative Sequence Current Injection by Wind Power Plants

    DEFF Research Database (Denmark)

    Chaudhary, Sanjay; Göksu, Ömer; Teodorescu, Remus;

    2013-01-01

    This paper presents an analysis of the impact from negative sequence current injection by wind power plants in power systems under steady-state and short-term unbalanced conditions, including faults. The separate positive and negative sequence current control capability of the grid-side converters...... of full scale converter type wind turbines may be utilized to alter voltage imbalance at the point of connection and further into the grid, in turn changing the resultant negative sequence current flow in the grid. The effects of such control actions have been analyzed and discussed through theoretical...

  11. Inferring Neuronal Network Connectivity using Time-constrained Episodes

    CERN Document Server

    Patnaik, Debprakash; Unnikrishnan, K P

    2007-01-01

    Discovering frequent episodes in event sequences is an interesting data mining task. In this paper, we argue that this framework is very effective for analyzing multi-neuronal spike train data. Analyzing spike train data is an important problem in neuroscience though there are no data mining approaches reported for this. Motivated by this application, we introduce different temporal constraints on the occurrences of episodes. We present algorithms for discovering frequent episodes under temporal constraints. Through simulations, we show that our method is very effective for analyzing spike train data for unearthing underlying connectivity patterns.

  12. Connecting multimodality in human communication.

    Science.gov (United States)

    Regenbogen, Christina; Habel, Ute; Kellermann, Thilo

    2013-01-01

    A successful reciprocal evaluation of social signals serves as a prerequisite for social coherence and empathy. In a previous fMRI study we studied naturalistic communication situations by presenting video clips to our participants and recording their behavioral responses regarding empathy and its components. In two conditions, all three channels transported congruent emotional or neutral information, respectively. Three conditions selectively presented two emotional channels and one neutral channel and were thus bimodally emotional. We reported channel-specific emotional contributions in modality-related areas, elicited by dynamic video clips with varying combinations of emotionality in facial expressions, prosody, and speech content. However, to better understand the underlying mechanisms accompanying a naturalistically displayed human social interaction in some key regions that presumably serve as specific processing hubs for facial expressions, prosody, and speech content, we pursued a reanalysis of the data. Here, we focused on two different descriptions of temporal characteristics within these three modality-related regions [right fusiform gyrus (FFG), left auditory cortex (AC), left angular gyrus (AG) and left dorsomedial prefrontal cortex (dmPFC)]. By means of a finite impulse response (FIR) analysis within each of the three regions we examined the post-stimulus time-courses as a description of the temporal characteristics of the BOLD response during the video clips. Second, effective connectivity between these areas and the left dmPFC was analyzed using dynamic causal modeling (DCM) in order to describe condition-related modulatory influences on the coupling between these regions. The FIR analysis showed initially diminished activation in bimodally emotional conditions but stronger activation than that observed in neutral videos toward the end of the stimuli, possibly by bottom-up processes in order to compensate for a lack of emotional information. The

  13. Dual Authentication For Bluetooth Connection

    Directory of Open Access Journals (Sweden)

    Diallo Alhassane Saliou

    2014-07-01

    Full Text Available Recently, Bluetooth technology is widely used by organizations and individuals to provide wireless personal area network (WPAN. This is because the radio frequency (RF waves can easily penetrate obstacles and can propagate without direct line-of-sight (LoS. These two characteristics have led to replace wired communication by wireless systems. However, there are serious security challenges associated with wireless communication systems because they are easier to eavesdrop, disrupt and jam than the wired systems. Bluetooth technology started with a form of pairing called legacy pairing prior to any communication. However, due to the serious security issues found in the legacy pairing, a secure and simple pairing called SPP was announced with Bluetooth 2.1 and later since 2007. SPP has solved the main security issue which is the weaknesses of the PIN code in the legacy pairing, however it has been found with some vulnerabilities such as eavesdropping and man-in-the-middle (MITM attacks. Since the discovery of these vulnerabilities, some enhancements have been proposed to the Bluetooth Specification Interest Group (SIG which is the regulatory body of Bluetooth technology; nevertheless, some proposed enhancements are ineffective or are not yet implemented by Manufacturers. Therefore, an improvement of the security authentication in Bluetooth connection is highly required to overcome the existing drawbacks. This proposed protocol uses Hash-based Message Authentication Code (HMAC algorithm with Secure Hash Algorithm (SHA-256. The implementation of this proposal is based on the Arduino Integrated Development Environment (IDE as software and a Bluetooth (BT Shield connected to an Arduino Uno R3 boards as hardware. The result was verified on a Graphical User Interface (GUI built in Microsoft Visual Studio 2010 with C sharp as default environment. It has shown that the proposed scheme works perfectly with the used hardware and software. In addition, the

  14. Yeast genome sequencing:

    DEFF Research Database (Denmark)

    Piskur, Jure; Langkjær, Rikke Breinhold

    2004-01-01

    For decades, unicellular yeasts have been general models to help understand the eukaryotic cell and also our own biology. Recently, over a dozen yeast genomes have been sequenced, providing the basis to resolve several complex biological questions. Analysis of the novel sequence data has shown...... of closely related species helps in gene annotation and to answer how many genes there really are within the genomes. Analysis of non-coding regions among closely related species has provided an example of how to determine novel gene regulatory sequences, which were previously difficult to analyse because...... they are short and degenerate and occupy different positions. Comparative genomics helps to understand the origin of yeasts and points out crucial molecular events in yeast evolutionary history, such as whole-genome duplication and horizontal gene transfer(s). In addition, the accumulating sequence data provide...

  15. In Favor of Sequencing?

    NARCIS (Netherlands)

    van der Borgh, G.J.C.

    2014-01-01

    This short article is a contribution to an online discussion about political sequencing and stability. It argues that despite all the risks of democratization in fragile states,a more gradual approach should be preferred.

  16. Scope and Sequence.

    Science.gov (United States)

    Callison, Daniel

    2002-01-01

    Discusses scope and sequence plans for curriculum coordination in elementary and secondary education related to school libraries. Highlights include library skills; levels of learning objectives; technology skills; media literacy skills; and information inquiry skills across disciplines by grade level. (LRW)

  17. Pierre Robin sequence

    Science.gov (United States)

    Pierre Robin syndrome; Pierre Robin complex; Pierre Robin anomaly ... The exact causes of Pierre Robin sequence are unknown. It may be part of many genetic syndromes. The lower jaw develops slowly before birth, but may grow ...

  18. Generalized magnetofluid connections in relativistic magnetohydrodynamics.

    Science.gov (United States)

    Asenjo, Felipe A; Comisso, Luca

    2015-03-20

    The concept of magnetic connections is extended to nonideal relativistic magnetohydrodynamical plasmas. Adopting a general set of equations for relativistic magnetohydrodynamics including thermal-inertial, thermal electromotive, Hall, and current-inertia effects, we derive a new covariant connection equation showing the existence of generalized magnetofluid connections that are preserved during the dissipationless plasma dynamics. These connections are intimately linked to a general antisymmetric tensor that unifies the electromagnetic and fluid fields, allowing the extension of the magnetic connection notion to a much broader concept.

  19. Generalized magnetofluid connections in pair plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Asenjo, Felipe A., E-mail: felipe.asenjo@uai.cl [Facultad de Ingeniería y Ciencias, Universidad Adolfo Ibáñez, Santiago 7941169 (Chile); Comisso, Luca, E-mail: lcomisso@princeton.edu [Department of Astrophysical Sciences and Princeton Plasma Physics Laboratory, Princeton University, Princeton, New Jersey 08544 (United States); Dipartimento Energia, Politecnico di Torino, Torino 10129, Italy and Istituto dei Sistemi Complessi-CNR, Roma 00185 (Italy); Mahajan, Swadesh M., E-mail: mahajan@mail.utexas.edu [Institute for Fusion Studies, The University of Texas at Austin, Austin, Texas 78712 (United States)

    2015-12-15

    We extend the magnetic connection theorem of ideal magnetohydrodynamics to nonideal relativistic pair plasmas. Adopting a generalized Ohm's law, we prove the existence of generalized magnetofluid connections that are preserved by the plasma dynamics. We show that these connections are related to a general antisymmetric tensor that unifies the electromagnetic and fluid fields. The generalized magnetofluid connections set important constraints on the plasma dynamics by forbidding transitions between configurations with different magnetofluid connectivity. An approximated solution is explicitly shown where the corrections due to current inertial effects are found.

  20. Behavior of concentrically loaded CFT braces connections

    Directory of Open Access Journals (Sweden)

    Maha M. Hassan

    2014-03-01

    Full Text Available Concrete filled tubes (CFTs composite columns have many economical and esthetic advantages, but the behavior of their connections is complicated. Through this study, it is aimed to investigate the performance and behavior of different connection configurations between concrete filled steel tube columns and bracing diagonals through an experimental program. The study included 12 connection subassemblies consisting of a fixed length steel tube and gusset plate connected to the tube end with different details tested under half cyclic loading. A notable effect was observed on the behavior of the connections due to its detailing changes with respect to capacity, failure mode, ductility, and stress distribution.

  1. Behavior of concentrically loaded CFT braces connections.

    Science.gov (United States)

    Hassan, Maha M; Ramadan, Hazem M; Abdel-Mooty, Mohammed N; Mourad, Sherif A

    2014-03-01

    Concrete filled tubes (CFTs) composite columns have many economical and esthetic advantages, but the behavior of their connections is complicated. Through this study, it is aimed to investigate the performance and behavior of different connection configurations between concrete filled steel tube columns and bracing diagonals through an experimental program. The study included 12 connection subassemblies consisting of a fixed length steel tube and gusset plate connected to the tube end with different details tested under half cyclic loading. A notable effect was observed on the behavior of the connections due to its detailing changes with respect to capacity, failure mode, ductility, and stress distribution.

  2. Vortex generated fluid flows in multiply connected domains

    CERN Document Server

    Zemlyanova, Anna; Handley, Demond

    2016-01-01

    A fluid flow in a multiply connected domain generated by an arbitrary number of point vortices is considered. A stream function for this flow is constructed as a limit of a certain functional sequence using the method of images. The convergence of this sequence is discussed, and the speed of convergence is determined explicitly. The presented formulas allow for the easy computation of the values of the stream function with arbitrary precision in the case of well-separated cylinders. The considered problem is important for applications such as eddy flows in the oceans. Moreover, since finding the stream function of the flow is essentially identical to finding the modified Green's function for Laplace's equation, the presented method can be applied to a more general class of applied problems which involve solving the Dirichlet problem for Laplace's equation.

  3. HIV Sequence Compendium 2010

    Energy Technology Data Exchange (ETDEWEB)

    Kuiken, Carla [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Foley, Brian [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Leitner, Thomas [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Apetrei, Christian [Univ. of Pittsburgh, PA (United States); Hahn, Beatrice [Univ. of Alabama, Tuscaloosa, AL (United States); Mizrachi, Ilene [National Center for Biotechnology Information, Bethesda, MD (United States); Mullins, James [Univ. of Washington, Seattle, WA (United States); Rambaut, Andrew [Univ. of Edinburgh, Scotland (United Kingdom); Wolinsky, Steven [Northwestern Univ., Evanston, IL (United States); Korber, Bette [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2010-12-31

    This compendium is an annual printed summary of the data contained in the HIV sequence database. In these compendia we try to present a judicious selection of the data in such a way that it is of maximum utility to HIV researchers. Each of the alignments attempts to display the genetic variability within the different species, groups and subtypes of the virus. This compendium contains sequences published before January 1, 2010. Hence, though it is called the 2010 Compendium, its contents correspond to the 2009 curated alignments on our website. The number of sequences in the HIV database is still increasing exponentially. In total, at the time of printing, there were 339,306 sequences in the HIV Sequence Database, an increase of 45% since last year. The number of near complete genomes (>7000 nucleotides) increased to 2576 by end of 2009, reflecting a smaller increase than in previous years. However, as in previous years, the compendium alignments contain only a small fraction of these. Included in the alignments are a small number of sequences representing each of the subtypes and the more prevalent circulating recombinant forms (CRFs) such as 01 and 02, as well as a few outgroup sequences (group O and N and SIV-CPZ). Of the rarer CRFs we included one representative each. A more complete version of all alignments is available on our website, http://www.hiv.lanl.gov/content/sequence/NEWALIGN/align.html. Reprints are available from our website in the form of both HTML and PDF files. As always, we are open to complaints and suggestions for improvement. Inquiries and comments regarding the compendium should be addressed to seq-info@lanl.gov.

  4. Biological sequence analysis

    DEFF Research Database (Denmark)

    Durbin, Richard; Eddy, Sean; Krogh, Anders Stærmose

    This book provides an up-to-date and tutorial-level overview of sequence analysis methods, with particular emphasis on probabilistic modelling. Discussed methods include pairwise alignment, hidden Markov models, multiple alignment, profile searches, RNA secondary structure analysis, and phylogene......This book provides an up-to-date and tutorial-level overview of sequence analysis methods, with particular emphasis on probabilistic modelling. Discussed methods include pairwise alignment, hidden Markov models, multiple alignment, profile searches, RNA secondary structure analysis...

  5. Text Mining: (Asynchronous Sequences

    Directory of Open Access Journals (Sweden)

    Sheema Khan

    2014-12-01

    Full Text Available In this paper we tried to correlate text sequences those provides common topics for semantic clues. We propose a two step method for asynchronous text mining. Step one check for the common topics in the sequences and isolates these with their timestamps. Step two takes the topic and tries to give the timestamp of the text document. After multiple repetitions of step two, we could give optimum result.

  6. Proliferating Connections and Communicating Convergence

    Directory of Open Access Journals (Sweden)

    Aylish Wood

    2008-01-01

    Full Text Available In this paper I use the work of Niklas Luhmann to explore what pressure the concept of convergence exerts over how we communicate about the changing expressive practices of digital games following the emergence of digital technologies. My claim will be that in its current form, convergence privileges either the human users of technological platforms, or the combination of aesthetic conventions from different media what connects is either the user or the aesthetic code. While neither of these two positions would be likely to deny a reliance on the interplay between humans and technologies, such an interplay is taken for granted rather than explored. By using Luhmann’s version of systems theory, I argue that we can more effectively grasp the interplay of human and technological participants by understanding their combined roles in changing expressive practices.

  7. Unity connecting module in SSPF

    Science.gov (United States)

    1998-01-01

    In the Space Station Processing Facility, the Unity connecting module, part of the International Space Station, is shown with Pressurized Mating Adapters 1 (left) and 2 (right) attached. Unity is scheduled to undergo testing of the common berthing mechanism to which other space station elements will dock. Unity is the primary payload on mission STS-88, targeted to launch Dec. 3, 1998. Other testing includes the Pad Demonstration Test to verify the compatibility of the module with the Space Shuttle as well as the ability of the astronauts to send and receive commands to Unity from the flight deck of the orbiter. Unity is expected to be ready for installation into the payload canister on Oct. 25, and transported to Launch Pad 39-A on Oct. 27. The Unity will be mated to the Russian-built Zarya control module which should already be in orbit at that time.

  8. Sprays and Cartan projective connections

    Science.gov (United States)

    Saunders, D. J.

    2004-10-01

    Around 80 years ago, several authors (for instance H. Weyl, T.Y. Thomas, J. Douglas and J.H.C. Whitehead) studied the projective geometry of paths, using the methods of tensor calculus. The principal object of study was a spray, namely a homogeneous second-order differential equation, or more generally a projective equivalence class of sprays. At around the same time, E. Cartan studied the same topic from a different point of view, by imagining a projective space attached to a manifold, or, more generally, attached to a `manifold of elements'; the infinitesimal `glue' may be interpreted in modern language as a Cartan projective connection on a principal bundle. This paper describes the geometrical relationship between these two points of view.

  9. Method for hermetic electrical connections

    Science.gov (United States)

    Monroe, Saundra L.; Glass, S. Jill; Stone, Ronnie G.; Bond, Jamey T.; Susan, Donald F.

    2011-12-27

    A method of providing a hermetic, electrical connection between two electrical components by mating at least one metal pin in a glass-ceramic to metal seal connector to two electrical components, wherein the glass-ceramic to metal seal connector incorporates at least one metal pin encased (sealed) in a glass-ceramic material inside of a metal housing, with the glass-ceramic material made from 65-80% SiO.sub.2, 8-16% Li.sub.2O, 2-8% Al.sub.2O.sub.3, 1-5% P.sub.2O.sub.5, 1-8% K.sub.2O, 0.5-7% B.sub.2O.sub.3, and 0-5% ZnO. The connector retains hermeticity at temperatures as high as 700.degree. C. and pressures as high as 500 psi.

  10. Galaxy Morphology - Halo Gas Connections

    CERN Document Server

    Kacprzak, G G; Steidel, C C; Kacprzak, Glenn G.; Churchill, Christopher W.; Steidel, Charles C.

    2005-01-01

    We studied a sample of 38 intermediate redshift MgII absorption-selected galaxies using (1) Keck/HIRES and VLT/UVES quasar spectra to measure the halo gas kinematics from MgII absorption profiles and (2) HST/WFPC-2 images to study the absorbing galaxy morphologies. We have searched for correlations between quantified gas absorption properties, and host galaxy impact parameters, inclinations, position angles, and quantified morphological parameters. We report a 3.2-sigma correlation between asymmetric perturbations in the host galaxy morphology and the MgII absorption equivalent width. We suggest that this correlation may indicate a connection between past merging and/or interaction events in MgII absorption-selected galaxies and the velocity dispersion and quantity of gas surrounding these galaxies.

  11. GATA: a graphic alignment tool for comparative sequence analysis

    Directory of Open Access Journals (Sweden)

    Nix David A

    2005-01-01

    Full Text Available Abstract Background Several problems exist with current methods used to align DNA sequences for comparative sequence analysis. Most dynamic programming algorithms assume that conserved sequence elements are collinear. This assumption appears valid when comparing orthologous protein coding sequences. Functional constraints on proteins provide strong selective pressure against sequence inversions, and minimize sequence duplications and feature shuffling. For non-coding sequences this collinearity assumption is often invalid. For example, enhancers contain clusters of transcription factor binding sites that change in number, orientation, and spacing during evolution yet the enhancer retains its activity. Dot plot analysis is often used to estimate non-coding sequence relatedness. Yet dot plots do not actually align sequences and thus cannot account well for base insertions or deletions. Moreover, they lack an adequate statistical framework for comparing sequence relatedness and are limited to pairwise comparisons. Lastly, dot plots and dynamic programming text outputs fail to provide an intuitive means for visualizing DNA alignments. Results To address some of these issues, we created a stand alone, platform independent, graphic alignment tool for comparative sequence analysis (GATA http://gata.sourceforge.net/. GATA uses the NCBI-BLASTN program and extensive post-processing to identify all small sub-alignments above a low cut-off score. These are graphed as two shaded boxes, one for each sequence, connected by a line using the coordinate system of their parent sequence. Shading and colour are used to indicate score and orientation. A variety of options exist for querying, modifying and retrieving conserved sequence elements. Extensive gene annotation can be added to both sequences using a standardized General Feature Format (GFF file. Conclusions GATA uses the NCBI-BLASTN program in conjunction with post-processing to exhaustively align two DNA

  12. [Connective tissue and prolapse genesis].

    Science.gov (United States)

    Tremollieres, F

    2010-06-01

    The pathophysiology of pelvic floor disorders still remains not well understood. Increasing age as well as vaginal multiparity are the main commonly accepted factors. The hypothesis of a defect of connective tissues of the pelvic floor with aging due to collagen deficiency and/or elastic fiber degradation is often highlighted. The issue of a potential protective role of HRT is also discussed although the recent results from the WHI would suggest a negative impact of HRT on urinary incontinence, especially when HRT is initiated in elderly women, far from the menopause. Nevertheless, environmental factors cannot explain the full pathogenesis of pelvic organ prolapse (POP) and the contribution of genetic factors to the development of pelvic floor disorders is widely recognized. Support for a genetic influence on POP derives from reports suggesting that heritability is a strong contributing factor and a familial history of POP is considered as a classical risk factor. However, the characterization of the underlying molecular mechanisms remains limited, since POP may be considered the end result of a multifactorial process leading to destruction of vaginal wall connective tissue. Experimental studies in mice with null mutations in the genes encoding different putative factors involved in elastic fibers remodeling and homeostasis are crucial in the understanding of the pathogenesis of POP. Mice with null mutation in the gene encoding lysyl oxidase-like 1 (LOXL1) or fibulin-5, demonstrate signs of elastinopathy including the development of a POP in the postpartum. Likewise, homeobox genes such as HOXA11, which are essential in the embryonic development of the urogenital tract might also be involved in the pathogenesis of POP. The better understanding of the underlying determinants of pelvic floor disorders with a special focus on genetic factors may offer new therapeutic strategies, in addition to or replacement of surgical procedures.

  13. Radiotherapy in patients with connective tissue diseases.

    Science.gov (United States)

    Giaj-Levra, Niccolò; Sciascia, Savino; Fiorentino, Alba; Fersino, Sergio; Mazzola, Rosario; Ricchetti, Francesco; Roccatello, Dario; Alongi, Filippo

    2016-03-01

    The decision to offer radiotherapy in patients with connective tissue diseases continues to be challenging. Radiotherapy might trigger the onset of connective tissue diseases by increasing the expression of self-antigens, diminishing regulatory T-cell activity, and activating effectors of innate immunity (dendritic cells) through Toll-like receptor-dependent mechanisms, all of which could potentially lead to breaks of immune tolerance. This potential risk has raised some debate among radiation oncologists about whether patients with connective tissue diseases can tolerate radiation as well as people without connective tissue diseases. Because the number of patients with cancer and connective tissue diseases needing radiotherapy will probably increase due to improvements in medical treatment and longer life expectancy, the issue of interactions between radiotherapy and connective tissue diseases needs to be clearer. In this Review, we discuss available data and evidence for patients with connective tissue diseases treated with radiotherapy.

  14. Hematopoietic stem cell origin of connective tissues.

    Science.gov (United States)

    Ogawa, Makio; Larue, Amanda C; Watson, Patricia M; Watson, Dennis K

    2010-07-01

    Connective tissue consists of "connective tissue proper," which is further divided into loose and dense (fibrous) connective tissues and "specialized connective tissues." Specialized connective tissues consist of blood, adipose tissue, cartilage, and bone. In both loose and dense connective tissues, the principal cellular element is fibroblasts. It has been generally believed that all cellular elements of connective tissue, including fibroblasts, adipocytes, chondrocytes, and bone cells, are generated solely by mesenchymal stem cells. Recently, a number of studies, including those from our laboratory based on transplantation of single hematopoietic stem cells, strongly suggested a hematopoietic stem cell origin of these adult mesenchymal tissues. This review summarizes the experimental evidence for this new paradigm and discusses its translational implications.

  15. STRENGTH DESIGN OF PREMIUM THREADED CASING CONNECTION

    Institute of Scientific and Technical Information of China (English)

    Gao Lianxin; Jin Ye; Zhang Yi

    2004-01-01

    Using premium casing connections instead of API ones is one of the most effective technique to prevent casing failure.The factors contribute to the strength of premium casing connections are studied with FEA and full-scale test.The criterions are presented that ensure the connection's strength higher than the pipe.At the same time, the method is given to decrease the peak stress of the connection so as to improve its anticorruption property.At last, full-scale tests are done to test the strength of the connections designed with the method described, the results show that the connection's strength is higher than the pipe.This indicated that the method described is effective in designing premium casing connection.

  16. [Gastroenterologic aspects of connective tissue diseases].

    Science.gov (United States)

    Altomonte, L; Zoli, A; Alessi, F; Ghirlanda, G; Greco, A V; Magarò, M

    1985-07-14

    The connective tissue disorders are a protean group of acquired diseases which have in common widespread immunologic and inflammatory alterations of connective tissue. The acquired connective tissue diseases generally include the following clinical entities: rheumatoid arthritis, systemic lupus erythematosus, polymyositis, polyarteritis nodosa, scleroderma, mixed connective tissue disease, Sjögren's and Behcet's sindromes. These entities have certain features in common which include sinovitis, pleuritis, myocarditis, endocarditis, pericarditis, peritonitis, vasculitis, myositis, changes in skin, alteration of connective tissue and nephritis. Gastrointestinal and hepatic involvement in connective tissue disorders are not the most important features, nevertheless appear almost regularly. Anorexia, nausea, vomiting, abdominal pain, malabsorption may affect patients suffering by rheumatoid arthritis, systemic lupus erythematosus and other collagenophaties. In some cases mesenteric vasculitis may cause intestinal ischemia which may result in bowel infarction, mucosal ulceration, hemorrhage, perforation. After an extensive review of the existing literature the Authors make an accurate evaluation of gastrointestinal and hepatic alterations in connective tissue diseases.

  17. Investigation into Methods for Predicting Connection Temperatures

    Directory of Open Access Journals (Sweden)

    K. Anderson

    2009-01-01

    Full Text Available The mechanical response of connections in fire is largely based on material strength degradation and the interactions between the various components of the connection. In order to predict connection performance in fire, temperature profiles must initially be established in order to evaluate the material strength degradation over time. This paper examines two current methods for predicting connection temperatures: The percentage method, where connection temperatures are calculated as a percentage of the adjacent beam lower-flange, mid-span temperatures; and the lumped capacitance method, based on the lumped mass of the connection. Results from the percentage method do not correlate well with experimental results, whereas the lumped capacitance method shows much better agreement with average connection temperatures. A 3D finite element heat transfer model was also created in Abaqus, and showed good correlation with experimental results. 

  18. Continued fractions and heavy sequences

    CERN Document Server

    Boshernitzan, Michael

    2009-01-01

    We initiate the study of the sets $H(c)$, $0=x-[x]$ stands for the fractional part of $x\\in \\mathbb R$. We prove that, for rational $c$, the sets $H(c)$ are of positive Hausdorff dimension and, in particular, are uncountable. For integers $m\\geq1$, we obtain a surprising characterization of the numbers $\\alpha\\in H_m= H(\\frac1m)$ in terms of their continued fraction expansions: The odd entries (partial quotients) of these expansions are divisible by $m$. The characterization implies that $x\\in H_m$ if and only if $\\frac 1{mx} \\in H_m$, for $x>0$. We are unaware of a direct proof of this equivalence, without making a use of the mentioned characterization of the sets $H_m$. We also introduce the dual sets $\\hat H_m$ of reals $y$ for which the sequence of integers $\\big([ky]\\big)_{k\\geq1}$ consistently hits the set $m\\mathbb Z$ with the at least expected frequency $\\frac1m$ and establish the connection with the sets $H_m$: {2mm} If $xy=m$ for $x,y>0$, then $x\\in H_m$ if and only if $y\\in \\hat H_m$. The motivatio...

  19. Structural Connectivity of the Developing Human Amygdala

    Science.gov (United States)

    Saygin, Zeynep M.; Osher, David E.; Koldewyn, Kami; Martin, Rebecca E.; Finn, Amy; Saxe, Rebecca; Gabrieli, John D.E.; Sheridan, Margaret

    2015-01-01

    A large corpus of research suggests that there are changes in the manner and degree to which the amygdala supports cognitive and emotional function across development. One possible basis for these developmental differences could be the maturation of amygdalar connections with the rest of the brain. Recent functional connectivity studies support this conclusion, but the structural connectivity of the developing amygdala and its different nuclei remains largely unstudied. We examined age related changes in the DWI connectivity fingerprints of the amygdala to the rest of the brain in 166 individuals of ages 5-30. We also developed a model to predict age based on individual-subject amygdala connectivity, and identified the connections that were most predictive of age. Finally, we segmented the amygdala into its four main nucleus groups, and examined the developmental changes in connectivity for each nucleus. We observed that with age, amygdalar connectivity becomes increasingly sparse and localized. Age related changes were largely localized to the subregions of the amygdala that are implicated in social inference and contextual memory (the basal and lateral nuclei). The central nucleus’ connectivity also showed differences with age but these differences affected fewer target regions than the basal and lateral nuclei. The medial nucleus did not exhibit any age related changes. These findings demonstrate increasing specificity in the connectivity patterns of amygdalar nuclei across age. PMID:25875758

  20. Structural connectivity of the developing human amygdala.

    Directory of Open Access Journals (Sweden)

    Zeynep M Saygin

    Full Text Available A large corpus of research suggests that there are changes in the manner and degree to which the amygdala supports cognitive and emotional function across development. One possible basis for these developmental differences could be the maturation of amygdalar connections with the rest of the brain. Recent functional connectivity studies support this conclusion, but the structural connectivity of the developing amygdala and its different nuclei remains largely unstudied. We examined age related changes in the DWI connectivity fingerprints of the amygdala to the rest of the brain in 166 individuals of ages 5-30. We also developed a model to predict age based on individual-subject amygdala connectivity, and identified the connections that were most predictive of age. Finally, we segmented the amygdala into its four main nucleus groups, and examined the developmental changes in connectivity for each nucleus. We observed that with age, amygdalar connectivity becomes increasingly sparse and localized. Age related changes were largely localized to the subregions of the amygdala that are implicated in social inference and contextual memory (the basal and lateral nuclei. The central nucleus' connectivity also showed differences with age but these differences affected fewer target regions than the basal and lateral nuclei. The medial nucleus did not exhibit any age related changes. These findings demonstrate increasing specificity in the connectivity patterns of amygdalar nuclei across age.

  1. Local Natural Connectivity in Complex Networks

    Institute of Scientific and Technical Information of China (English)

    SHANG Yi-Lun

    2011-01-01

    @@ In network theory, a complex network represents a system whose evolving structure and dynamic behavior contribute to its robustness.The natural connectivity is recently proposed as a spectral measure to characterize the robustness of complex networks.We decompose the natural connectivity of a network as local natural connectivity of its connected components and quantify their contributions to the network robustness.In addition, we compare the natural connectivity of a network with that of an induced subgraph of it based on interlacing theorems.As an application, we derive an inequality for eigenvalues of ErdSs-Renyi random graphs.%In network theory, a complex network represents a system whose evolving structure and dynamic behavior contribute to its robustness. The natural connectivity is recently proposed as a spectral measure to characterize the robustness of complex networks. We decompose the natural connectivity of a network as local naturai connectivity of its connected components and quantify their contributions to the network robustness. In addition, we compare the naturai connectivity of a network with that of an induced subgraph of it based on interlacing theorems. As an application, we derive an inequality for eigenvalues of Erdos-Renyi random graphs.

  2. Boundary effects in welded steel moment connections

    Science.gov (United States)

    Lee, Kyoung-Hyeog

    Unprecedented widespread failure of welded moment connections in steel frames caused by the 1994 Northridge and the 1995 Kobe earthquakes have alarmed the engineering communities throughout the world. Welded moment connections in steel frames have been traditionally designed by using the classical beam theory which leads to assumptions that the flanges transfer moment while the web connection primarily resists the shear force. However, this study shows that the magnitude and direction of the principal stresses in the connection region are better approximated by using truss analogy rather than the classical beam theory. Accordingly, both the bending moment and the shear force are transferred across the connection near the beam flanges through diagonal strut action. Thus, the beam flange region of the traditionally designed connection is overloaded. This conclusion explains, to a large extent, the recently observed steel moment connection failures. In this study, detailed finite element analyses were carried out for a representative beam-to-column subassemblage with fully welded connection. The stress distribution in the beam web and flanges in the vicinity of the connection were closely studied. The factors responsible for stress redistribution and concentration were identified by using fundamental principles of mechanics. It was concluded that peak resultant stresses can exceed the values used in simple design calculations by large margins. Using the finite element analysis results and the truss analogy to establish a realistic load path in the connection, a practical and more rational analysis and design procedure was developed. The proposed design procedure and the new connection details were successfully validated through cyclic load testing of a nearly full size specimen. The truss model represented the force transmission around the beam-to-column moment connection region very well. Results of the finite element analyses and the laboratory testing showed

  3. Adaptive Processing for Sequence Alignment

    KAUST Repository

    Zidan, Mohammed Affan

    2012-01-26

    Disclosed are various embodiments for adaptive processing for sequence alignment. In one embodiment, among others, a method includes obtaining a query sequence and a plurality of database sequences. A first portion of the plurality of database sequences is distributed to a central processing unit (CPU) and a second portion of the plurality of database sequences is distributed to a graphical processing unit (GPU) based upon a predetermined splitting ratio associated with the plurality of database sequences, where the database sequences of the first portion are shorter than the database sequences of the second portion. A first alignment score for the query sequence is determined with the CPU based upon the first portion of the plurality of database sequences and a second alignment score for the query sequence is determined with the GPU based upon the second portion of the plurality of database sequences.

  4. Program Synthesizes UML Sequence Diagrams

    Science.gov (United States)

    Barry, Matthew R.; Osborne, Richard N.

    2006-01-01

    A computer program called "Rational Sequence" generates Universal Modeling Language (UML) sequence diagrams of a target Java program running on a Java virtual machine (JVM). Rational Sequence thereby performs a reverse engineering function that aids in the design documentation of the target Java program. Whereas previously, the construction of sequence diagrams was a tedious manual process, Rational Sequence generates UML sequence diagrams automatically from the running Java code.

  5. Perfusion deficits and functional connectivity alterations in patients with post-traumatic stress disorder

    Science.gov (United States)

    Liu, Yang; Li, Baojuan; Zhang, Xi; Zhang, Linchuan; Li, Liang; Lu, Hongbing

    2016-03-01

    To explore the alteration in cerebral blood flow (CBF) and functional connectivity between survivors with recent onset post-traumatic stress disorder (PTSD) and without PTSD, survived from the same coal mine flood disaster. In this study, a processing pipeline using arterial spin labeling (ASL) sequence was proposed. Considering low spatial resolution of ASL sequence, a linear regression method was firstly used to correct the partial volume (PV) effect for better CBF estimation. Then the alterations of CBF between two groups were analyzed using both uncorrected and PV-corrected CBF maps. Based on altered CBF regions detected from the CBF analysis as seed regions, the functional connectivity abnormities in PTSD patients was investigated. The CBF analysis using PV-corrected maps indicates CBF deficits in the bilateral frontal lobe, right superior frontal gyrus and right corpus callosum of PTSD patients, while only right corpus callosum was identified in uncorrected CBF analysis. Furthermore, the regional CBF of the right superior frontal gyrus exhibits significantly negative correlation with the symptom severity in PTSD patients. The resting-state functional connectivity indicates increased connectivity between left frontal lobe and right parietal lobe. These results indicate that PV-corrected CBF exhibits more subtle perfusion changes and may benefit further perfusion and connectivity analysis. The symptom-specific perfusion deficits and aberrant connectivity in above memory-related regions may be putative biomarkers for recent onset PTSD induced by a single prolonged trauma exposure and help predict the severity of PTSD.

  6. Sequencing BPS Spectra

    CERN Document Server

    Gukov, Sergei; Saberi, Ingmar; Stosic, Marko; Sulkowski, Piotr

    2015-01-01

    This paper provides both a detailed study of color-dependence of link homologies, as realized in physics as certain spaces of BPS states, and a broad study of the behavior of BPS states in general. We consider how the spectrum of BPS states varies as continuous parameters of a theory are perturbed. This question can be posed in a wide variety of physical contexts, and we answer it by proposing that the relationship between unperturbed and perturbed BPS spectra is described by a spectral sequence. These general considerations unify previous applications of spectral sequence techniques to physics, and explain from a physical standpoint the appearance of many spectral sequences relating various link homology theories to one another. We also study structural properties of colored HOMFLY homology for links and evaluate Poincar\\'e polynomials in numerous examples. Among these structural properties is a novel "sliding" property, which can be explained by using (refined) modular $S$-matrix. This leads to the identifi...

  7. Connectivity of channelized reservoirs: a modelling approach

    Energy Technology Data Exchange (ETDEWEB)

    Larue, David K. [ChevronTexaco, Bakersfield, CA (United States); Hovadik, Joseph [ChevronTexaco, San Ramon, CA (United States)

    2006-07-01

    Connectivity represents one of the fundamental properties of a reservoir that directly affects recovery. If a portion of the reservoir is not connected to a well, it cannot be drained. Geobody or sandbody connectivity is defined as the percentage of the reservoir that is connected, and reservoir connectivity is defined as the percentage of the reservoir that is connected to wells. Previous studies have mostly considered mathematical, physical and engineering aspects of connectivity. In the current study, the stratigraphy of connectivity is characterized using simple, 3D geostatistical models. Based on these modelling studies, stratigraphic connectivity is good, usually greater than 90%, if the net: gross ratio, or sand fraction, is greater than about 30%. At net: gross values less than 30%, there is a rapid diminishment of connectivity as a function of net: gross. This behaviour between net: gross and connectivity defines a characteristic 'S-curve', in which the connectivity is high for net: gross values above 30%, then diminishes rapidly and approaches 0. Well configuration factors that can influence reservoir connectivity are well density, well orientation (vertical or horizontal; horizontal parallel to channels or perpendicular) and length of completion zones. Reservoir connectivity as a function of net: gross can be improved by several factors: presence of overbank sandy facies, deposition of channels in a channel belt, deposition of channels with high width/thickness ratios, and deposition of channels during variable floodplain aggradation rates. Connectivity can be reduced substantially in two-dimensional reservoirs, in map view or in cross-section, by volume support effects and by stratigraphic heterogeneities. It is well known that in two dimensions, the cascade zone for the 'S-curve' of net: gross plotted against connectivity occurs at about 60% net: gross. Generalizing this knowledge, any time that a reservoir can be regarded as &apos

  8. Conformal transformation of tetrads and spin connection

    CERN Document Server

    Chakrabarty, Subhasish

    2016-01-01

    We investigate the conformal transformation of vierbein-Einstein-Palatini (VEP) action in terms of tetrads $e^I_\\mu$ and spin connection $A^{IJ}_\\mu$. The transformation of tetrads is obtained from that of the spacetime metric whereas that of the spin connection is not unique off-shell. When the connection can be completely expressed in terms of the tetrads, its transformation follows from that of the tetrads. We also construct the conformally invariant scalar field in the VEP formalism.

  9. Evoked Effective Connectivity of the Human Neocortex

    OpenAIRE

    Entz, László; Tóth, Emília; Keller, Corey J.; Bickel, Stephan; Groppe, David M.; Fabó, Dániel; Kozák, Lajos R.; Eroőss, Loránd; Ulbert, István; Mehta, Ashesh D.

    2014-01-01

    The role of cortical connectivity in brain function and pathology is increasingly being recognized. While in vivo magnetic resonance imaging studies have provided important insights into anatomical and functional connectivity, these methodologies are limited in their ability to detect electrophysiological activity and the causal relationships that underlie effective connectivity. Here, we describe results of cortico-cortical evoked potential (CCEP) mapping using single pulse electrical stimul...

  10. Abnormal Asymmetry of Brain Connectivity in Schizophrenia

    OpenAIRE

    Ribolsi, Michele; Zafiris J Daskalakis; Siracusano, Alberto; Koch, Giacomo

    2014-01-01

    Recently, a growing body of data has revealed that beyond a dysfunction of connectivity among different brain areas in schizophrenia patients (SCZ), there is also an abnormal asymmetry of functional connectivity compared with healthy subjects. The loss of the cerebral torque and the abnormalities of gyrification, with an increased or more complex cortical folding in the right hemisphere may provide an anatomical basis for such aberrant connectivity in SCZ. Furthermore, diffusion tensor imagin...

  11. Connection method of separated luminal regions of intestine from CT volumes

    Science.gov (United States)

    Oda, Masahiro; Kitasaka, Takayuki; Furukawa, Kazuhiro; Watanabe, Osamu; Ando, Takafumi; Hirooka, Yoshiki; Goto, Hidemi; Mori, Kensaku

    2015-03-01

    This paper proposes a connection method of separated luminal regions of the intestine for Crohn's disease diagnosis. Crohn's disease is an inflammatory disease of the digestive tract. Capsule or conventional endoscopic diagnosis is performed for Crohn's disease diagnosis. However, parts of the intestines may not be observed in the endoscopic diagnosis if intestinal stenosis occurs. Endoscopes cannot pass through the stenosed parts. CT image-based diagnosis is developed as an alternative choice of the Crohn's disease. CT image-based diagnosis enables physicians to observe the entire intestines even if stenosed parts exist. CAD systems for Crohn's disease using CT volumes are recently developed. Such CAD systems need to reconstruct separated luminal regions of the intestines to analyze intestines. We propose a connection method of separated luminal regions of the intestines segmented from CT volumes. The luminal regions of the intestines are segmented from a CT volume. The centerlines of the luminal regions are calculated by using a thinning process. We enumerate all the possible sequences of the centerline segments. In this work, we newly introduce a condition using distance between connected ends points of the centerline segments. This condition eliminates unnatural connections of the centerline segments. Also, this condition reduces processing time. After generating a sequence list of the centerline segments, the correct sequence is obtained by using an evaluation function. We connect the luminal regions based on the correct sequence. Our experiments using four CT volumes showed that our method connected 6.5 out of 8.0 centerline segments per case. Processing times of the proposed method were reduced from the previous method.

  12. Plasmodium falciparum antigenic variation. Mapping mosaic var gene sequences onto a network of shared, highly polymorphic sequence blocks.

    Science.gov (United States)

    Bull, Peter C; Buckee, Caroline O; Kyes, Sue; Kortok, Moses M; Thathy, Vandana; Guyah, Bernard; Stoute, José A; Newbold, Chris I; Marsh, Kevin

    2008-06-01

    Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a potentially important family of immune targets, encoded by an extremely diverse gene family called var. Understanding of the genetic organization of var genes is hampered by sequence mosaicism that results from a long history of non-homologous recombination. Here we have used software designed to analyse social networks to visualize the relationships between large collections of short var sequences tags sampled from clinical parasite isolates. In this approach, two sequences are connected if they share one or more highly polymorphic sequence blocks. The results show that the majority of analysed sequences including several var-like sequences from the chimpanzee parasite Plasmodium reichenowi can be either directly or indirectly linked together in a single unbroken network. However, the network is highly structured and contains putative subgroups of recombining sequences. The major subgroup contains the previously described group A var genes, previously proposed to be genetically distinct. Another subgroup contains sequences found to be associated with rosetting, a parasite virulence phenotype. The mosaic structure of the sequences and their division into subgroups may reflect the conflicting problems of maximizing antigenic diversity and minimizing epitope sharing between variants while maintaining their host cell binding functions.

  13. Connectivity in the deep: Phylogeography of the velvet belly lanternshark

    Science.gov (United States)

    Gubili, Chrysoula; Macleod, Kirsty; Perry, William; Hanel, Pia; Batzakas, Ioannis; Farrell, Edward D.; Lynghammar, Arve; Mancusi, Cecilia; Mariani, Stefano; Menezes, Gui M.; Neat, Francis; Scarcella, Giuseppe; Griffiths, Andrew M.

    2016-09-01

    The velvet belly lanternshark, Etmopterus spinax, is a deep-sea bioluminescent squaloid shark, found predominantly in the Northeast Atlantic and Mediterranean Sea. It has been exposed to relatively high levels of mortality associated with by-catch in some regions. Its late maturity and low fecundity potentially renders it vulnerable to over-exploitation, although little remains known about processes of connectivity between key habitats/regions. This study utilised DNA sequencing of partial regions of the mitochondrial control region and nuclear ribosomal internal transcribed spacer 2 to investigate population structure and phylogeography of this species across the Northeast Atlantic and Mediterranean Basin. Despite the inclusion of samples from the range edges or remote locations, no evidence of significant population structure was detected. An important exception was identified using the control region sequence, with much greater (and statistically significant) levels of genetic differentiation between the Mediterranean and Atlantic. This suggests that the Strait of Gibraltar may represent an important bathymetric barrier, separating regions with very low levels of female dispersal. Bayesian estimation of divergence time also places the separation between the Mediterranean and Atlantic lineages within the last 100,000 years, presumably connected with perturbations during the last Glacial Period. These results demonstrate population subdivision at a much smaller geographic distance than has generally been identified in previous work on deep-sea sharks. This highlights a very significant role for shallow bathymetry in promoting genetic differentiation in deepwater taxa. It acts as an important exception to a general paradigm of marine species being connected by high levels of gene-flow, representing single stocks over large scales. It may also have significant implications for the fisheries management of this species.

  14. Essential Connectivity Areas - CEHC, (Raster) [ds620

    Data.gov (United States)

    California Department of Resources — The California Department of Transportation (Caltrans) and California Department of Fish and Game (CDFG) commissioned the California Essential Habitat Connectivity...

  15. Neighborhood connected perfect domination in graphs

    Directory of Open Access Journals (Sweden)

    Kulandai Vel M.P.

    2012-12-01

    Full Text Available Let $G = (V, E$ be a connected graph. A set $S$ of vertices in $G$ is a perfect dominating set if every vertex $v$ in $V-S$ is adjacent to exactly one vertex in $S$. A perfect dominating set $S$ is said to be a neighborhood connected perfect dominating set (ncpd-set if the induced subgraph $$ is connected. The minimum cardinality of a ncpd-set of $G$ is called the neighborhood connected perfect domination number of $G$ and is denoted by $\\gamma_{ncp}(G$. In this paper we initiate a study of this parameter.

  16. Affine connections, midpoint formation, and point reflection

    DEFF Research Database (Denmark)

    Kock, Anders

    2011-01-01

    We describe some differential-geometric structures in combinatorial terms: namely affine connections and their torsion and curvature, and we show that torsion free affine connections may equivalently be presented in terms of some simpler combinatorial structure: midpoint formation, and point refl...... reflection (geodesic symmetry). The method employed is that of synthetic differential geometry, which is briefly explained.......We describe some differential-geometric structures in combinatorial terms: namely affine connections and their torsion and curvature, and we show that torsion free affine connections may equivalently be presented in terms of some simpler combinatorial structure: midpoint formation, and point...

  17. Connecting multimodality in human communication

    Directory of Open Access Journals (Sweden)

    Christina eRegenbogen

    2013-11-01

    Full Text Available A successful reciprocal evaluation of social signals serves as a prerequisite for social coherence and empathy. In a previous fMRI study we studied naturalistic communication situations by presenting video clips to our participants and recording their behavioral responses regarding empathy and its components. In two conditions, all three channels transported congruent emotional or neutral information, respectively. Three conditions selectively presented two emotional channels and one neutral channel and were thus bimodally emotional. We reported channel-specific emotional contributions in modality-related areas, elicited by dynamic video clips with varying combinations of emotionality in facial expressions, prosody, and speech content. However, to better understand the underlying mechanisms accompanying a naturalistically displayed human social interaction in some key regions that presumably serve as specific processing hubs for facial expressions, prosody, and speech content, we pursued a reanalysis of the data. In addition to this specificity of these regions to information channels we demonstrated that they were also sensitive to variations of the respective emotional content.Here, we focused on two different descriptions of temporal characteristics within these three modality-related regions (right fusiform gyrus (FFG, left auditory cortex (AC, left angular gyrus (AG and left dorsomedial prefrontal cortex (dmPFC. By means of a finite impulse response (FIR analysis within each of the three regions we examined the post-stimulus time-courses as a description of the temporal characteristics of the BOLD response during the video clips. Second, effective connectivity between these areas and the left dmPFC was analyzed using dynamic causal modeling (DCM in order to describe condition-related modulatory influences on the coupling between these regions. The FIR analysis showed initially diminished activation in bimodally emotional conditions but

  18. Twin anemia polycythemia sequence

    NARCIS (Netherlands)

    Slaghekke, Femke

    2014-01-01

    In this thesis we describe that Twin Anemia Polycythemia Sequence (TAPS) is a form of chronic feto-fetal transfusion in monochorionic (identical) twins based on a small amount of blood transfusion through very small anastomoses. For the antenatal diagnosis of TAPS, Middle Cerebral Artery – Peak Syst

  19. Family Sequencing and Cooperation

    NARCIS (Netherlands)

    Grundel, S.; Ciftci, B.B.; Borm, P.E.M.; Hamers, H.J.M.

    2012-01-01

    To analyze the allocation problem of the maximal cost savings of the whole group of jobs, we define and analyze a so-called corresponding cooperative family sequencing game which explicitly takes into account the maximal cost savings for any coalition of jobs. Using nonstandard techniques we prove t

  20. A Multidata Connection Scheme for Big Data High-Dimension Using the Data Connection Coefficient

    Directory of Open Access Journals (Sweden)

    Yoon-su Jeong

    2015-01-01

    Full Text Available In the era of big data and cloud computing, sources and types of data vary, and the volume and flow of data are massive and continuous. With the widespread use of mobile devices and the Internet, huge volumes of data distributed over heterogeneous networks move forward and backward across networks. In order to meet the demands of big data service providers and customers, efficient technologies for processing and transferring big data over networks are needed. This paper proposes a multidata connection (MDC scheme that decreases the amount of power and time necessary for information to be communicated between the content server and the mobile users (i.e., the content consumers who are moving freely across different networks while using their mobile devices. MDC scheme is an approach to data validation that requires the presentation of two or more pieces of data in a heterogeneous environment of big data. The MDC transmits the difference of the consecutive data sequences instead of sending the data itself to the receiver, thus increasing transmission throughput and speed.

  1. An efficient algorithm for identifying matches with errors in multiple long molecular sequences.

    Science.gov (United States)

    Leung, M Y; Blaisdell, B E; Burge, C; Karlin, S

    1991-10-20

    An efficient algorithm is described for finding matches, repeats and other word relations, allowing for errors, in large data sets of long molecular sequences. The algorithm entails hashing on fixed-size words in conjunction with the use of a linked list connecting all occurrences of the same word. The average memory and run time requirement both increase almost linearly with the total sequence length. Some results of the program's performance on a database of Escherichia coli DNA sequences are presented.

  2. Functional connectivity of parietal cortex during temporal selective attention.

    Science.gov (United States)

    Tyler, Sarah C; Dasgupta, Samhita; Agosta, Sara; Battelli, Lorella; Grossman, Emily D

    2015-04-01

    Perception of natural experiences requires allocation of attention towards features, objects, and events that are moving and changing over time. This allocation of attention is controlled by large-scale brain networks that, when damaged, cause widespread cognitive deficits. In particular, damage to ventral parietal cortex (right lateralized TPJ, STS, supramarginal and angular gyri) is associated with failures to selectively attend to and isolate features embedded within rapidly changing visual sequences (Battelli, Pascual-Leone, & Cavanagh, 2007; Husain, Shapiro, Martin, & Kennard, 1997). In this study, we used fMRI to investigate the neural activity and functional connectivity of intact parietal cortex while typical subjects judged the relative onsets and offsets of rapidly flickering tokens (a phase discrimination task in which right parietal patients are impaired). We found two regions in parietal cortex correlated with task performance: a bilateral posterior TPJ (pTPJ) and an anterior right-lateralized TPJ (R aTPJ). Both regions were deactivated when subjects engaged in the task but showed different patterns of functional connectivity. The bilateral pTPJ was strongly connected to nodes within the default mode network (DMN) and the R aTPJ was connected to the attention network. Accurate phase discriminations were associated with increased functional correlations between sensory cortex (hMT+) and the bilateral pTPJ, whereas accuracy on a control task was associated with yoked activity in the hMT+ and the R aTPJ. We conclude that temporal selective attention is particularly sensitive for revealing information pathways between sensory and core cognitive control networks that, when damaged, can lead to nonspatial attention impairments in right parietal stroke patients.

  3. Internal representation of hierarchical sequences involves the default network

    Directory of Open Access Journals (Sweden)

    Rogers Baxter P

    2010-04-01

    Full Text Available Abstract Background The default network is a set of brain regions that exhibit a reduction in BOLD response during attention-demanding cognitive tasks, and distinctive patterns of functional connectivity that typically include anti-correlations with a fronto-parietal network involved in attention, working memory, and executive control. The function of the default network regions has been attributed to introspection, self-awareness, and theory of mind judgments, and some of its regions are involved in episodic memory processes. Results Using the method of psycho-physiological interactions, we studied the functional connectivity of several regions in a fronto-parietal network involved in a paired image discrimination task involving transitive inference. Some image pairs were derived from an implicit underlying sequence A>B>C>D>E, and some were independent (F>G, H>J, etc. Functional connectivity between the fronto-parietal regions and the default network regions depended on the presence of the underlying sequence relating the images. When subjects viewed learned and novel pairs from the sequence, connectivity between these two networks was higher than when subjects viewed learned and novel pairs from the independent sets. Conclusions These results suggest that default network regions were involved in maintaining the internal model that subserved discrimination of image pairs derived from the implicit sequence, and contributed to introspective access of an internal sequence model built during training. The default network may not be a unified entity with a specific function, but rather may interact with other functional networks in task-dependent ways.

  4. Road Weather and Connected Vehicles

    Science.gov (United States)

    Pisano, P.; Boyce, B. C.

    2015-12-01

    On average, there are over 5.8 M vehicle crashes each year of which 23% are weather-related. Weather-related crashes are defined as those crashes that occur in adverse weather or on slick pavement. The vast majority of weather-related crashes happen on wet pavement (74%) and during rainfall (46%). Connected vehicle technologies hold the promise to transform road-weather management by providing improved road weather data in real time with greater temporal and geographic accuracy. This will dramatically expand the amount of data that can be used to assess, forecast, and address the impacts that weather has on roads, vehicles, and travelers. The use of vehicle-based measurements of the road and surrounding atmosphere with other, more traditional weather data sources, and create road and atmospheric hazard products for a variety of users. The broad availability of road weather data from mobile sources will vastly improve the ability to detect and forecast weather and road conditions, and will provide the capability to manage road-weather response on specific roadway links. The RWMP is currently demonstrating how weather, road conditions, and related vehicle data can be used for decision making through an innovative Integrated Mobile Observations project. FHWA is partnering with 3 DOTs (MN, MI, & NV) to pilot these applications. One is a mobile alerts application called the Motorists Advisories and Warnings (MAW) and a maintenance decision support application. These applications blend traditional weather information (e.g., radar, surface stations) with mobile vehicle data (e.g., temperature, brake status, wiper status) to determine current weather conditions. These weather conditions, and other road-travel-relevant information, are provided to users via web and phone applications. The MAW provides nowcasts and short-term forecasts out to 24 hours while the EMDSS application can provide forecasts up to 72 hours in advance. The three DOTs have placed readers and external

  5. Strong Connections and Invertible Weak Entwining Structures

    Institute of Scientific and Technical Information of China (English)

    J.N.ALONSO (A)LVAREZ; J.M.FERN(A)NDEZ VILABOA; R.GONZ(A)LEZ RODR(I)GUEZ

    2012-01-01

    In this paper we obtain a criterion under which the bijectivity of the canonical morphism of a weak Galois extension associated to a weak invertible entwining structure is equivalent to the existence of a strong connection form.Also we obtain an explicit formula for a strong connection under equivariant projective conditions or under coseparability conditions.

  6. Water Treatment Technology - Cross-Connections.

    Science.gov (United States)

    Ross-Harrington, Melinda; Kincaid, G. David

    One of twelve water treatment technology units, this student manual on cross connections provides instructional materials for two competencies. (The twelve units are designed for a continuing education training course for public water supply operators.) The competencies focus on cross connections terminology and control devices. For each…

  7. Grid OCL : A Graphical Object Connecting Language

    Science.gov (United States)

    Taylor, I. J.; Schutz, B. F.

    In this paper, we present an overview of the Grid OCL graphical object connecting language. Grid OCL is an extension of Grid, introduced last year, that allows users to interactively build complex data processing systems by selecting a set of desired tools and connecting them together graphically. Algorithms written in this way can now also be run outside the graphical environment.

  8. Connecting Representations: Using Predict, Check, Explain

    Science.gov (United States)

    Roy, George J.; Fueyo, Vivian; Vahey, Philip; Knudsen, Jennifer; Rafanan, Ken; Lara-Meloy, Teresa

    2016-01-01

    Although educators agree that making connections with the real world, as advocated by "Principles to Actions: Ensuring Mathematical Success for All" (NCTM 2014), is important, making such connections while addressing important mathematics is elusive. The authors have found that math content coupled with the instructional strategy of…

  9. Countering oversegmentation in partitioning-based connectivities

    NARCIS (Netherlands)

    Ouzounis, Georgios K.; Wilkinson, Michael H.F.

    2005-01-01

    A new theoretical development is presented for handling the over-segmentation problem in partitioning-based connected openings. The definition we propose treats singletons generated with the earlier method, as elements of a larger connected component. Unlike the existing formalism, this new method a

  10. Natural Connections on Riemannian Product Manifolds

    OpenAIRE

    Gribacheva, Dobrinka

    2011-01-01

    A Riemannian almost product manifold with integrable almost product structure is called a Riemannian product manifold. In the present paper the natural connections on such manifolds are studied, i.e. the linear connections preserving the almost product structure and the Riemannian metric.

  11. Science and Mathematics--A Natural Connection

    Science.gov (United States)

    Park Rogers, Meredith A.; Volkmann, Mark J.; Abell, Sandra K.

    2007-01-01

    Connections between science and mathematics seem natural. First, mathematics can be used in science to organize and analyze data in tables and graphs. Second, mathematics can help represent scientific phenomena and understand scientific concepts. Student learning should benefit when teachers make the connections between science and mathematics…

  12. Elders' Lifelong Connection with the Natural Environment

    Science.gov (United States)

    Carman, Jack

    2011-01-01

    Our interaction with nature does not end just because we age. People have a lifelong connection with the outdoor environment in varying degrees. For some, this participation may be subtle by simply watching others interact with the outdoor environment. For others, there is a deeper connection with nature through gardening, birding, exercise,…

  13. Removable Edges in a 5-Connected Graph

    Institute of Scientific and Technical Information of China (English)

    Li Qiong XU; Xiao Feng GU

    2011-01-01

    An edge e of a k-connected graph G is said to be a removable edge if G Θ e is still k-connected,where G Θ e denotes the graph obtained from G by deleting e to get G-e,and for any end vertex of e with degree k-1 in G-e,say x,delete x,and then add edges between any pair of non-adjacent vertices in NC_e(x).The existence of removable edges of k-connected graphs and some properties of 3-connected and 4-connected graphs have been investigated[1,11,14,15].In the present paper,we investigate some properties of 5-connected graphs and study the distribution of removable edges on a cycle and a spanning tree in a 5-connected graph.Based on the properties,we proved that for a 5-connected graph G of order at least 10,if the edge-vertex-atom of G contains at least three vertices,then G has at least (3|G|+2)/2 removable edges.

  14. MedlinePlus Connect: How it Works

    Science.gov (United States)

    ... page for more examples of Web Application response pages. Web Service The MedlinePlus Connect REST-based Web service ... to the user. Visit the Web Service Demonstration page for more examples of Web Service response pages. More Information How MedlinePlus Connect ...

  15. A Random Walk: Stumbling across Connections

    Science.gov (United States)

    Wasserman, Nicholas H.

    2015-01-01

    Finding and designing tasks that allow for students to make connections among mathematical ideas is important for mathematics educators. One such task, which affords students the opportunity to make connections and engage with significant mathematical ideas through a variety of problem-solving approaches, is described in this article. Three…

  16. Connecting Functions in Geometry and Algebra

    Science.gov (United States)

    Steketee, Scott; Scher, Daniel

    2016-01-01

    One goal of a mathematics education is that students make significant connections among different branches of mathematics. Connections--such as those between arithmetic and algebra, between two-dimensional and three-dimensional geometry, between compass-and-straight-edge constructions and transformations, and between calculus and analytic…

  17. Are we connected? : Ports in Global Networks

    NARCIS (Netherlands)

    R.A. Zuidwijk (Rob)

    2015-01-01

    markdownabstractAbstract Global supply chains are built on organizational, information, and logistics networks. Ports are connected via these networks and also need to connect these networks. Synchromodality is an innovative concept for container transportation, and the port plays an important ro

  18. Making Connections between Research and Practice

    Science.gov (United States)

    Porter, Andrew; McMaken, Jennifer

    2009-01-01

    Strengthening connections between research and practice is an important goal in education. Making the connection has both a supply side and a demand side but the demand is often ignored in education. The authors offer six hypotheses about why this situation occurs.

  19. Directional connectivity in hydrology and ecology.

    Science.gov (United States)

    Larsen, Laurel G; Choi, Jungyill; Nungesser, Martha K; Harvey, Judson W

    2012-12-01

    Quantifying hydrologic and ecological connectivity has contributed to understanding transport and dispersal processes and assessing ecosystem degradation or restoration potential. However, there has been little synthesis across disciplines. The growing field of ecohydrology and recent recognition that loss of hydrologic connectivity is leading to a global decline in biodiversity underscore the need for a unified connectivity concept. One outstanding need is a way to quantify directional connectivity that is consistent, robust to variations in sampling, and transferable across scales or environmental settings. Understanding connectivity in a particular direction (e.g., streamwise, along or across gradient, between sources and sinks, along cardinal directions) provides critical information for predicting contaminant transport, planning conservation corridor design, and understanding how landscapes or hydroscapes respond to directional forces like wind or water flow. Here we synthesize progress on quantifying connectivity and develop a new strategy for evaluating directional connectivity that benefits from use of graph theory in ecology and percolation theory in hydrology. The directional connectivity index (DCI) is a graph-theory based, multiscale metric that is generalizable to a range of different structural and functional connectivity applications. It exhibits minimal sensitivity to image rotation or resolution within a given range and responds intuitively to progressive, unidirectional change. Further, it is linearly related to the integral connectivity scale length--a metric common in hydrology that correlates well with actual fluxes--but is less computationally challenging and more readily comparable across different landscapes. Connectivity-orientation curves (i.e., directional connectivity computed over a range of headings) provide a quantitative, information-dense representation of environmental structure that can be used for comparison or detection of

  20. Directional connectivity in hydrology and ecology

    Science.gov (United States)

    Larsen, Laurel G.; Choi, Jungyill; Nungesser, Martha K.; Harvey, Judson W.

    2012-01-01

    Quantifying hydrologic and ecological connectivity has contributed to understanding transport and dispersal processes and assessing ecosystem degradation or restoration potential. However, there has been little synthesis across disciplines. The growing field of ecohydrology and recent recognition that loss of hydrologic connectivity is leading to a global decline in biodiversity underscore the need for a unified connectivity concept. One outstanding need is a way to quantify directional connectivity that is consistent, robust to variations in sampling, and transferable across scales or environmental settings. Understanding connectivity in a particular direction (e.g., streamwise, along or across gradient, between sources and sinks, along cardinal directions) provides critical information for predicting contaminant transport, planning conservation corridor design, and understanding how landscapes or hydroscapes respond to directional forces like wind or water flow. Here we synthesize progress on quantifying connectivity and develop a new strategy for evaluating directional connectivity that benefits from use of graph theory in ecology and percolation theory in hydrology. The directional connectivity index (DCI) is a graph-theory based, multiscale metric that is generalizable to a range of different structural and functional connectivity applications. It exhibits minimal sensitivity to image rotation or resolution within a given range and responds intuitively to progressive, unidirectional change. Further, it is linearly related to the integral connectivity scale length—a metric common in hydrology that correlates well with actual fluxes—but is less computationally challenging and more readily comparable across different landscapes. Connectivity-orientation curves (i.e., directional connectivity computed over a range of headings) provide a quantitative, information-dense representation of environmental structure that can be used for comparison or detection of

  1. 29 CFR Appendix H to Subpart R of... - Double Connections: Illustration of a Clipped End Connection and a Staggered Connection: Non...

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 8 2010-07-01 2010-07-01 false Double Connections: Illustration of a Clipped End Connection and a Staggered Connection: Non-Mandatory Guidelines for Complying With § 1926.756(c)(1) H...: Illustration of a Clipped End Connection and a Staggered Connection: Non-Mandatory Guidelines for...

  2. Spin connection and renormalization of teleparallel action

    Energy Technology Data Exchange (ETDEWEB)

    Krššák, Martin, E-mail: krssak@ift.unesp.br; Pereira, J. G., E-mail: jpereira@ift.unesp.br [Instituto de Física Teórica, Universidade Estadual Paulista, R. Dr. Bento Teobaldo Ferraz 271, 01140-070, São Paulo, SP (Brazil)

    2015-10-31

    In general relativity, inertia and gravitation are both included in the Levi–Civita connection. As a consequence, the gravitational action, as well as the corresponding energy–momentum density, are in general contaminated by spurious contributions coming from inertial effects. In teleparallel gravity, on the other hand, because the spin connection represents inertial effects only, it is possible to separate inertia from gravitation. Relying on this property, it is shown that to each tetrad there is naturally associated a spin connection that locally removes the inertial effects from the action. The use of the appropriate spin connection can be viewed as a renormalization process in the sense that the computation of energy and momentum naturally yields the physically relevant values. A self-consistent method for solving field equations and determining the appropriate spin connection is presented.

  3. Discrete Cocompact Subgroups of the Five-Dimensional Connected and Simply Connected Nilpotent Lie Groups

    Directory of Open Access Journals (Sweden)

    Amira Ghorbel

    2009-02-01

    Full Text Available The discrete cocompact subgroups of the five-dimensional connected, simply connected nilpotent Lie groups are determined up to isomorphism. Moreover, we prove if G = N × A is a connected, simply connected, nilpotent Lie group with an Abelian factor A, then every uniform subgroup of G is the direct product of a uniform subgroup of N and Z^r where r = dim A.

  4. Liaison concatenation – A method to obtain feasible assembly sequences from 3D-CAD product

    Indian Academy of Sciences (India)

    M V A Raju Bahubalendruni; Bibhuti Bhusan Biswal

    2016-01-01

    Selection of optimized assembly sequence from the available feasible assembly sequences is significantly essential to achieve cost-effective manufacturing process. To achieve this, at the outset, generation of feasible assembly sequences with topological, geometrical, precedence and stability conditions should be generated. The increase of part count in a product results huge number of assembly sequences, the Liaison matrix/Liaison graph generated based on the connections between the assembly components eliminates nonpossible assembly sequences at the initial phase. There exist methods namely cut-set method to eliminate the non-possible assembly sequences using liaison graph. In this paper a new approach to eliminate the non-possible assembly sequences based on liaisons is described and the correctness of the methodology is illustrated with an example. The methodology to obtain the feasible assembly sequences is also briefly described and presented. An algorithm to interface with the CAD environment is described briefly.

  5. Next-generation sequencing

    DEFF Research Database (Denmark)

    Rieneck, Klaus; Bak, Mads; Jønson, Lars

    2013-01-01

    , Illumina); several millions of PCR sequences were analyzed. RESULTS: The results demonstrated the feasibility of diagnosing the fetal KEL1 or KEL2 blood group from cell-free DNA purified from maternal plasma. CONCLUSION: This method requires only one primer pair, and the large amount of sequence......BACKGROUND: Maternal immunization against KEL1 of the Kell blood group system can have serious adverse consequences for the fetus as well as the newborn baby. Therefore, it is important to determine the phenotype of the fetus to predict whether it is at risk. We present data that show...... information obtained allows well for statistical analysis of the data. This general approach can be integrated into current laboratory practice and has numerous applications. Besides DNA-based predictions of blood group phenotypes, platelet phenotypes, or sickle cell anemia, and the determination of zygosity...

  6. Rapid-Sequence Intubation

    Directory of Open Access Journals (Sweden)

    Evangelina Dávila Cabo de Villa

    2015-09-01

    Full Text Available In medical practice there are several situations that require immediate intervention of the airway in some patients, in order to ensure proper entrance and exit of gases into and out of the lungs and prevent aspiration. Rapid-sequence intubation has been considered as the administration of a hypnotic agent and a neuromuscular relaxant consecutively (virtually simultaneously to facilitate orotracheal intubation in critically ill patients and minimize the risk of aspiration. This paper aims to collect elements that promote a successful medical management according to the situation presented, since there is no single way of proceeding in case of rapid-sequence intubation. The elements to consider include: knowing the anatomy of the upper respiratory tract, having a group of drugs to choose from, receiving adequate training and having an alternative plan for the difficulties that may arise.

  7. Sequencing of aromatase inhibitors

    OpenAIRE

    2005-01-01

    Since the development of the third-generation aromatase inhibitors (AIs), anastrozole, letrozole and exemestane, these agents have been the subject of intensive research to determine their optimal use in advanced breast cancer. Not only have they replaced progestins in second-line therapy and challenged the role of tamoxifen in first-line, but there is also evidence for a lack of cross-resistance between the steroidal and nonsteroidal AIs, meaning that they may be used in sequence to obtain p...

  8. Learning Sequence Neighbourhood Metrics

    CERN Document Server

    Bayer, Justin; van der Smagt, Patrick

    2011-01-01

    Recurrent neural networks (RNNs) in combination with a pooling operator and the neighbourhood components analysis (NCA) objective function are able to detect the characterizing dynamics of sequences and embed them into a fixed-length vector space of arbitrary dimensionality. Subsequently, the resulting features are meaningful and can be used for visualization or nearest neighbour classification in linear time. This kind of metric learning for sequential data enables the use of algorithms tailored towards fixed length vector spaces such as R^n.

  9. Sequence Classification: 885394 [

    Lifescience Database Archive (English)

    Full Text Available 703); The expression pattern of this gene is described in PMID:12000842; possible frameshift detected when compare...Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|23619146|ref|NP_705108.1| Slight difference exist when compa...red to the published sequence of EBL-1 from Dd2 strain of P. falciparum (PMID:10613

  10. Properties of Semijoin Sequences

    Institute of Scientific and Technical Information of China (English)

    BengC.Ooi; B.Srinivasan

    1989-01-01

    The problem of finding optimum semijoin sequ4ence of an arbitrary query under linear cost function for the transmission cost is NP.hard.Hence heuristic algorithms with desirable properties are explored.In this paper four properties of semijoin programs for distributed query processing are identified,The use of these properties in constructing semijoin sequence is justified.An existing algorithm is modified incorporating these properties.Empirical comparison with existing algorithms shows the superiority of the proposed algorithm.

  11. Natural environments, nature relatedness and the ecological theater: connecting satellites and sequencing to shinrin-yoku.

    Science.gov (United States)

    Craig, Jeffrey M; Logan, Alan C; Prescott, Susan L

    2016-01-13

    Recent advances in research concerning the public health value of natural environments have been remarkable. The growing interest in this topic (often housed under terms such as green and/or blue space) has been occurring in parallel with the microbiome revolution and an increased use of remote sensing technology in public health. In the context of biodiversity loss, rapid urbanization, and alarming rates of global non-communicable diseases (many associated with chronic, low-grade inflammation), discussions of natural vis-a-vis built environments are not merely fodder for intellectual curiosity. Here, we argue for increased interdisciplinary collaboration with the aim of better understanding the mechanisms-including aerobiological and epigenetic-that might help explain some of the noted positive health outcomes. It is our contention that some of these mechanisms are related to ecodiversity (i.e., the sum of biodiversity and geodiversity, including biotic and abiotic constituents). We also encourage researchers to more closely examine individual nature relatedness and how it might influence many outcomes that are at the interface of lifestyle habits and contact with ecodiversity.

  12. Image sequence analysis

    CERN Document Server

    1981-01-01

    The processing of image sequences has a broad spectrum of important applica­ tions including target tracking, robot navigation, bandwidth compression of TV conferencing video signals, studying the motion of biological cells using microcinematography, cloud tracking, and highway traffic monitoring. Image sequence processing involves a large amount of data. However, because of the progress in computer, LSI, and VLSI technologies, we have now reached a stage when many useful processing tasks can be done in a reasonable amount of time. As a result, research and development activities in image sequence analysis have recently been growing at a rapid pace. An IEEE Computer Society Workshop on Computer Analysis of Time-Varying Imagery was held in Philadelphia, April 5-6, 1979. A related special issue of the IEEE Transactions on Pattern Anal­ ysis and Machine Intelligence was published in November 1980. The IEEE Com­ puter magazine has also published a special issue on the subject in 1981. The purpose of this book ...

  13. Sequencing BPS spectra

    Science.gov (United States)

    Gukov, Sergei; Nawata, Satoshi; Saberi, Ingmar; Stošić, Marko; Sułkowski, Piotr

    2016-03-01

    This paper provides both a detailed study of color-dependence of link homologies, as realized in physics as certain spaces of BPS states, and a broad study of the behavior of BPS states in general. We consider how the spectrum of BPS states varies as continuous parameters of a theory are perturbed. This question can be posed in a wide variety of physical contexts, and we answer it by proposing that the relationship between unperturbed and perturbed BPS spectra is described by a spectral sequence. These general considerations unify previous applications of spectral sequence techniques to physics, and explain from a physical standpoint the appearance of many spectral sequences relating various link homology theories to one another. We also study structural properties of colored HOMFLY homology for links and evaluate Poincaré polynomials in numerous examples. Among these structural properties is a novel "sliding" property, which can be explained by using (refined) modular S-matrix. This leads to the identification of modular transformations in Chern-Simons theory and 3d {N}=2 theory via the 3d/3d correspondence. Lastly, we introduce the notion of associated varieties as classical limits of recursion relations of colored superpolynomials of links, and study their properties.

  14. The Galaxy End Sequence

    Science.gov (United States)

    Eales, Stephen; de Vis, Pieter; Smith, Matthew W. L.; Appah, Kiran; Ciesla, Laure; Duffield, Chris; Schofield, Simon

    2017-03-01

    A common assumption is that galaxies fall in two distinct regions of a plot of specific star formation rate (SSFR) versus galaxy stellar mass: a star-forming galaxy main sequence (GMS) and a separate region of 'passive' or 'red and dead galaxies'. Starting from a volume-limited sample of nearby galaxies designed to contain most of the stellar mass in this volume, and thus representing the end-point of ≃12 billion years of galaxy evolution, we investigate the distribution of galaxies in this diagram today. We show that galaxies follow a strongly curved extended GMS with a steep negative slope at high galaxy stellar masses. There is a gradual change in the morphologies of the galaxies along this distribution, but there is no clear break between early-type and late-type galaxies. Examining the other evidence that there are two distinct populations, we argue that the 'red sequence' is the result of the colours of galaxies changing very little below a critical value of the SSFR, rather than implying a distinct population of galaxies. Herschel observations, which show at least half of early-type galaxies contain a cool interstellar medium, also imply continuity between early-type and late-type galaxies. This picture of a unitary population of galaxies requires more gradual evolutionary processes than the rapid quenching process needed to explain two distinct populations. We challenge theorists to predict quantitatively the properties of this 'Galaxy End Sequence'.

  15. Next-generation sequencing approaches in genetic rodent model systems to study functional effects of human genetic variation.

    NARCIS (Netherlands)

    Guryev, V.; Cuppen, E.

    2009-01-01

    Rapid advances in DNA sequencing improve existing techniques and enable new approaches in genetics and functional genomics, bringing about unprecedented coverage, resolution and sensitivity. Enhanced toolsets can facilitate the untangling of connections between genomic variation, environmental facto

  16. Next-generation sequencing approaches in genetic rodent model systems to study functional effects of human genetic variation

    NARCIS (Netherlands)

    Guryev, Victor; Cuppen, Edwin

    2009-01-01

    Rapid advances in DNA sequencing improve existing techniques and enable new approaches in genetics and functional genomics, bringing about unprecedented coverage, resolution and sensitivity. Enhanced toolsets can facilitate the untangling of connections between genomic variation, environmental facto

  17. Implicit sequence learning in people with Parkinson’s disease

    Directory of Open Access Journals (Sweden)

    Katherine R Gamble

    2014-08-01

    Full Text Available Implicit sequence learning involves learning about dependencies in sequences of events without intent to learn or awareness of what has been learned. Sequence learning is related to striatal dopamine levels, striatal activation, and integrity of white matter connections. People with Parkinson’s disease (PD have degeneration of dopamine-producing neurons, leading to dopamine deficiency and therefore striatal deficits, and they have difficulties with sequencing, including complex language comprehension and postural stability. Most research on implicit sequence learning in PD has used motor-based tasks. However, because PD presents with motor deficits, it is difficult to assess whether learning itself is impaired in these tasks. The present study used an implicit sequence learning task with a reduced motor component, the Triplets Learning Task (TLT. People with PD and age- and education-matched healthy older adults completed three sessions (each consisting of 10 blocks of 50 trials of the TLT. Results revealed that the PD group was able to learn the sequence, however, when learning was examined using a Half Blocks analysis (Nemeth et al., 2013, which compared learning in the 1st 25/50 trials of all blocks to that in the 2nd 25/50 trials, the PD group showed significantly less learning than Controls in the 2nd Half Blocks, but not in the 1st. Nemeth et al. hypothesized that the 1st Half Blocks involve recall and reactivation of the sequence learned, thus reflecting hippocampal-dependent learning, while the 2nd Half Blocks involve proceduralized behavior of learned sequences, reflecting striatal-based learning. The present results suggest that the PD group had intact hippocampal-dependent implicit sequence learning, but impaired striatal-dependent learning. Thus, sequencing deficits in PD are likely due to striatal impairments, but other brain systems, such as the hippocampus, may be able to partially compensate for striatal decline to improve

  18. Information Theory of DNA Sequencing

    CERN Document Server

    Motahari, Abolfazl; Tse, David

    2012-01-01

    DNA sequencing is the basic workhorse of modern day biology and medicine. Shotgun sequencing is the dominant technique used: many randomly located short fragments called reads are extracted from the DNA sequence, and these reads are assembled to reconstruct the original sequence. By drawing an analogy between the DNA sequencing problem and the classic communication problem, we define an information theoretic notion of sequencing capacity. This is the maximum number of DNA base pairs that can be resolved reliably per read, and provides a fundamental limit to the performance that can be achieved by any assembly algorithm. We compute the sequencing capacity explicitly for a simple statistical model of the DNA sequence and the read process. Using this framework, we also study the impact of noise in the read process on the sequencing capacity.

  19. Modeled Population Connectivity across the Hawaiian Archipelago.

    Science.gov (United States)

    Wren, Johanna L K; Kobayashi, Donald R; Jia, Yanli; Toonen, Robert J

    2016-01-01

    We present the first comprehensive estimate of connectivity of passive pelagic particles released from coral reef habitat throughout the Hawaiian Archipelago. Potential connectivity is calculated using a Lagrangian particle transport model coupled offline with currents generated by an oceanographic circulation model, MITgcm. The connectivity matrices show a surprising degree of self-recruitment and directional dispersal towards the northwest, from the Main Hawaiian Islands (MHI) to the northwestern Hawaiian Islands (NWHI). We identify three predicted connectivity breaks in the archipelago, that is, areas in the mid and northern part of the archipelago that have limited connections with surrounding islands and reefs. Predicted regions of limited connectivity generally match observed patterns of genetic structure reported for coral reef species in the uninhabited NWHI, but multiple genetic breaks observed in the inhabited MHI are not explained by passive dispersal. The better congruence in our modeling results based on physical transport of passive particles in the low-lying atolls of the uninhabited NWHI, but not in the anthropogenically impacted high islands of the MHI begs the question: what ultimately controls connectivity in this system?

  20. Mapping hydrologic connectivity of geographically isolated wetlands

    Science.gov (United States)

    Ameli, Ali; Creed, Irena

    2016-04-01

    Geographically isolated wetlands (GIWs) are characterized as depressional landscape features completely surrounded by uplands. These small and typically circular landscape features represent a vast majority of wetlands in various landscapes in North America (98% of all wetlands in the Prairie Pothole Region). Geographical isolation, however, does not imply the hydrological isolation. Although geospatial data (e.g., aerial photos) suggested that GIWs lack a persistent surface water connection, the groundwater connection between GIWs and navigable downstream waters can be substantial with large fluxes at the regional scales. The surface/subsurface connections among GIWs and between GIWs and navigable waters are difficult to map and quantify. This is intimately tied to the fact that an efficient incorporation of these small geometric features and characterization of the mechanisms behind these connectivities are challenging within grid-based simulators. We used a physically-based grid-free groundwater-surface water interaction and surface flow routing schemes to map and assess the watershed-scale GIWs connectivity within an extensively studied watershed at the Canadian prairie pothole region with high density of GIWs. The results showed that there is a persistent subsurface connectivity among GIWs and between GIWs and navigable waters. Surface connection was rare and only occurred during extreme events. The results of this paper have significant implications for developing scientifically grounded environmental policy for protection of GIWs within North American Prairie.

  1. Low Pore Connectivity in Natural Rock

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Qinhong; Ewing, Robert P.; Dultz, Stefan

    2012-05-15

    As repositories for CO₂ and radioactive waste, as oil and gas reservoirs, and as contaminated sites needing remediation, rock formations play a central role in energy and environmental management. The connectivity of the rock's porespace strongly affects fluid flow and solute transport. This work examines pore connectivity and its implications for fluid flow and chemical transport. Three experimental approaches (imbibition, tracer concentration profiles, and imaging) were used in combination with network modeling. In the imbibition results, three types of imbibition slope [log (cumulative imbibition) vs. log (imbibition time)] were found: the classical 0.5, plus 0.26, and 0.26 transitioning to 0.5. The imbibition slope of 0.26 seen in Indiana sandstone, metagraywacke, and Barnett shale indicates low pore connectivity, in contrast to the slope of 0.5 seen in the well-connected Berea sandstone. In the tracer profile work, rocks exhibited different distances to the plateau porosity, consistent with the pore connectivity from the imbibition tests. Injection of a molten metal into connected pore spaces, followed by 2-D imaging of the solidified alloy in polished thin sections, allowed direct assessment of pore structure and lateral connection in the rock samples. Pore-scale network modeling gave results consistent with measurements, confirming pore connectivity as the underlying cause of both anomalous behaviors: imbibition slope not having the classical value of 0.5, and accessible porosity being a function of distance from the edge. A poorly connected porespace will exhibit anomalous behavior in fluid flow and chemical transport, such as a lower imbibition slope (in air–water system) and diffusion rate than expected from classical behavior.

  2. Low pore connectivity in natural rock.

    Science.gov (United States)

    Hu, Qinhong; Ewing, Robert P; Dultz, Stefan

    2012-05-15

    As repositories for CO(2) and radioactive waste, as oil and gas reservoirs, and as contaminated sites needing remediation, rock formations play a central role in energy and environmental management. The connectivity of the rock's porespace strongly affects fluid flow and solute transport. This work examines pore connectivity and its implications for fluid flow and chemical transport. Three experimental approaches (imbibition, tracer concentration profiles, and imaging) were used in combination with network modeling. In the imbibition results, three types of imbibition slope [log (cumulative imbibition) vs. log (imbibition time)] were found: the classical 0.5, plus 0.26, and 0.26 transitioning to 0.5. The imbibition slope of 0.26 seen in Indiana sandstone, metagraywacke, and Barnett shale indicates low pore connectivity, in contrast to the slope of 0.5 seen in the well-connected Berea sandstone. In the tracer profile work, rocks exhibited different distances to the plateau porosity, consistent with the pore connectivity from the imbibition tests. Injection of a molten metal into connected pore spaces, followed by 2-D imaging of the solidified alloy in polished thin sections, allowed direct assessment of pore structure and lateral connection in the rock samples. Pore-scale network modeling gave results consistent with measurements, confirming pore connectivity as the underlying cause of both anomalous behaviors: imbibition slope not having the classical value of 0.5, and accessible porosity being a function of distance from the edge. A poorly connected porespace will exhibit anomalous behavior in fluid flow and chemical transport, such as a lower imbibition slope (in air-water system) and diffusion rate than expected from classical behavior.

  3. Altered thalamic functional connectivity in multiple sclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Yaou; Liang, Peipeng; Duan, Yunyun; Huang, Jing; Ren, Zhuoqiong; Jia, Xiuqin [Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053 (China); Dong, Huiqing; Ye, Jing [Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053 (China); Shi, Fu-Dong [Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052 (China); Butzkueven, Helmut [Department of Medicine, University of Melbourne, Parkville 3010 (Australia); Li, Kuncheng, E-mail: kunchengli55@gmail.com [Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053 (China)

    2015-04-15

    Highlights: •We demonstrated decreased connectivity between thalamus and cortical regions in MS. •Increased intra- and inter-thalamic connectivity was also observed in MS. •The increased functional connectivity is attenuated by increasing disease duration. -- Abstract: Objective: To compare thalamic functional connectivity (FC) in patients with multiple sclerosis (MS) and healthy controls (HC), and correlate these connectivity measures with other MRI and clinical variables. Methods: We employed resting-state functional MRI (fMRI) to examine changes in thalamic connectivity by comparing thirty-five patients with MS and 35 age- and sex-matched HC. Thalamic FC was investigated by correlating low frequency fMRI signal fluctuations in thalamic voxels with voxels in all other brain regions. Additionally thalamic volume fraction (TF), T2 lesion volume (T2LV), EDSS and disease duration were recorded and correlated with the FC changes. Results: MS patients were found to have a significantly lower TF than HC in bilateral thalami. Compared to HC, the MS group showed significantly decreased FC between thalamus and several brain regions including right middle frontal and parahippocampal gyri, and the left inferior parietal lobule. Increased intra- and inter-thalamic FC was observed in the MS group compared to HC. These FC alterations were not correlated with T2LV, thalamic volume or lesions. In the MS group, however, there was a negative correlation between disease duration and inter-thalamic connectivity (r = −0.59, p < 0.001). Conclusion: We demonstrated decreased FC between thalamus and several cortical regions, while increased intra- and inter-thalamic connectivity in MS patients. These complex functional changes reflect impairments and/or adaptations that are independent of T2LV, thalamic volume or presence of thalamic lesions. The negative correlation between disease duration and inter-thalamic connectivity could indicate an adaptive role of thalamus that is

  4. A vision for ubiquitous sequencing.

    Science.gov (United States)

    Erlich, Yaniv

    2015-10-01

    Genomics has recently celebrated reaching the $1000 genome milestone, making affordable DNA sequencing a reality. With this goal successfully completed, the next goal of the sequencing revolution can be sequencing sensors--miniaturized sequencing devices that are manufactured for real-time applications and deployed in large quantities at low costs. The first part of this manuscript envisions applications that will benefit from moving the sequencers to the samples in a range of domains. In the second part, the manuscript outlines the critical barriers that need to be addressed in order to reach the goal of ubiquitous sequencing sensors.

  5. Psychoacoustic Properties of Fibonacci Sequences

    Directory of Open Access Journals (Sweden)

    J. Sokoll

    2008-01-01

    Full Text Available 1202, Fibonacci set up one of the most interesting sequences in number theory. This sequence can be represented by so-called Fibonacci Numbers, and by a binary sequence of zeros and ones. If such a binary Fibonacci Sequence is played back as an audio file, a very dissonant sound results. This is caused by the “almost-periodic”, “self-similar” property of the binary sequence. The ratio of zeros and ones converges to the golden ratio, as do the primary and secondary spectral components intheir frequencies and amplitudes. These Fibonacci Sequences will be characterized using listening tests and psychoacoustic analyses. 

  6. Detecting Functional Connectivity During Audiovisual Integration with MEG: A Comparison of Connectivity Metrics.

    Science.gov (United States)

    Ard, Tyler; Carver, Frederick W; Holroyd, Tom; Horwitz, Barry; Coppola, Richard

    2015-08-01

    In typical magnetoencephalography and/or electroencephalography functional connectivity analysis, researchers select one of several methods that measure a relationship between regions to determine connectivity, such as coherence, power correlations, and others. However, it is largely unknown if some are more suited than others for various types of investigations. In this study, the authors investigate seven connectivity metrics to evaluate which, if any, are sensitive to audiovisual integration by contrasting connectivity when tracking an audiovisual object versus connectivity when tracking a visual object uncorrelated with the auditory stimulus. The authors are able to assess the metrics' performances at detecting audiovisual integration by investigating connectivity between auditory and visual areas. Critically, the authors perform their investigation on a whole-cortex all-to-all mapping, avoiding confounds introduced in seed selection. The authors find that amplitude-based connectivity measures in the beta band detect strong connections between visual and auditory areas during audiovisual integration, specifically between V4/V5 and auditory cortices in the right hemisphere. Conversely, phase-based connectivity measures in the beta band as well as phase and power measures in alpha, gamma, and theta do not show connectivity between audiovisual areas. The authors postulate that while beta power correlations detect audiovisual integration in the current experimental context, it may not always be the best measure to detect connectivity. Instead, it is likely that the brain utilizes a variety of mechanisms in neuronal communication that may produce differential types of temporal relationships.

  7. Electrical connection structure for a superconductor element

    Science.gov (United States)

    Lallouet, Nicolas; Maguire, James

    2010-05-04

    The invention relates to an electrical connection structure for a superconductor element cooled by a cryogenic fluid and connected to an electrical bushing, which bushing passes successively through an enclosure at an intermediate temperature between ambient temperature and the temperature of the cryogenic fluid, and an enclosure at ambient temperature, said bushing projecting outside the ambient temperature enclosure. According to the invention, said intermediate enclosure is filled at least in part with a solid material of low thermal conductivity, such as a polyurethane foam or a cellular glass foam. The invention is applicable to connecting a superconductor cable at cryogenic temperature to a device for equipment at ambient temperature.

  8. Cooperation Strategies for Enhanced Connectivity at Home

    OpenAIRE

    Rossi, Claudio

    2014-01-01

    WHILE AT HOME , USERS MAY EXPERIENCE A POOR I NTERNET SERVICE while being connected to their 802.11 Access Points (APs). The AP is just one component of the Internet Gateway (GW) that generally includes a backhaul connection (ADSL, fiber,etc..) and a router providing a LAN. The root cause of performance degradation may be poor/congested wireless channel between the user and the GW or congested/bandwidth limited backhaul connection. The latter is a serious issue for DSL users that are located ...

  9. Intermittently connected mobile ad hoc networks

    CERN Document Server

    Jamalipour, Abbas

    2011-01-01

    In the last few years, there has been extensive research activity in the emerging area of Intermittently Connected Mobile Ad Hoc Networks (ICMANs). By considering the nature of intermittent connectivity in most real word mobile environments without any restrictions placed on users' behavior, ICMANs are eventually formed without any assumption with regard to the existence of a end-to-end path between two nodes wishing to communicate. It is different from the conventional Mobile Ad Hoc Networks (MANETs), which have been implicitly viewed as a connected graph with established complete paths betwe

  10. Is the spin connection confined or condensed?

    CERN Document Server

    Donoghue, John F

    2016-01-01

    The spin connection enters the theory of gravity as a nonabelian gauge field associated with local Lorentz transformations. Normally it is eliminated from making an extra assumption - that of the metricity of the vierbein field. However, treated by itself with the usual gauge action, it has a negative beta function, implying that it is asymptotically free. I suggest that the spin connection could be confined (or perhaps partially confined) in the same way as other nonabelian gauge fields. This would remove the need to make the extra assumption of metricity, as the spin connection would not be present in the low energy theory, leaving the symmetry to be realized only using metric variables.

  11. Resting state functional connectivity in perfusion imaging: correlation maps with BOLD connectivity and resting state perfusion.

    Directory of Open Access Journals (Sweden)

    Roberto Viviani

    Full Text Available Functional connectivity is a property of the resting state that may provide biomarkers of brain function and individual differences. Classically, connectivity is estimated as the temporal correlation of spontaneous fluctuations of BOLD signal. We investigated differences in connectivity estimated from the BOLD and CBF signal present in volumes acquired with arterial spin labeling technique in a large sample (N = 265 of healthy individuals. Positive connectivity was observable in both BOLD and CBF signal, and was present in the CBF signal also at frequencies lower than 0.009 Hz, here investigated for the first time. Negative connectivity was more variable. The validity of positive connectivity was confirmed by the existence of correlation across individuals in its intensity estimated from the BOLD and CBF signal. In contrast, there was little or no correlation across individuals between intensity of connectivity and mean perfusion levels, suggesting that these two biomarkers correspond to distinct sources of individual differences.

  12. Stochastically excited oscillations on the upper main sequence

    DEFF Research Database (Denmark)

    Antoci, Victoria

    2013-01-01

    Convective envelopes in stars on the main sequence are usually connected only with stars of spectral types F5 or later. However, observations as well as theory indicate that the convective outer layers in earlier stars, despite being shallow, are still effective and turbulent enough to stochastic......Convective envelopes in stars on the main sequence are usually connected only with stars of spectral types F5 or later. However, observations as well as theory indicate that the convective outer layers in earlier stars, despite being shallow, are still effective and turbulent enough...... to stochastically excite oscillations. Because of the low amplitudes, exploring stochastically excited pulsations became possible only with space missions such as Kepler and CoRoT. Here I review the recent results and discuss among others, pulsators such as delta Scuti, gamma Doradus, roAp, beta Cephei, Slowly...

  13. Infinite sequences and series

    CERN Document Server

    Knopp, Konrad

    1956-01-01

    One of the finest expositors in the field of modern mathematics, Dr. Konrad Knopp here concentrates on a topic that is of particular interest to 20th-century mathematicians and students. He develops the theory of infinite sequences and series from its beginnings to a point where the reader will be in a position to investigate more advanced stages on his own. The foundations of the theory are therefore presented with special care, while the developmental aspects are limited by the scope and purpose of the book. All definitions are clearly stated; all theorems are proved with enough detail to ma

  14. Networks that learn the precise timing of event sequences.

    Science.gov (United States)

    Veliz-Cuba, Alan; Shouval, Harel Z; Josić, Krešimir; Kilpatrick, Zachary P

    2015-12-01

    Neuronal circuits can learn and replay firing patterns evoked by sequences of sensory stimuli. After training, a brief cue can trigger a spatiotemporal pattern of neural activity similar to that evoked by a learned stimulus sequence. Network models show that such sequence learning can occur through the shaping of feedforward excitatory connectivity via long term plasticity. Previous models describe how event order can be learned, but they typically do not explain how precise timing can be recalled. We propose a mechanism for learning both the order and precise timing of event sequences. In our recurrent network model, long term plasticity leads to the learning of the sequence, while short term facilitation enables temporally precise replay of events. Learned synaptic weights between populations determine the time necessary for one population to activate another. Long term plasticity adjusts these weights so that the trained event times are matched during playback. While we chose short term facilitation as a time-tracking process, we also demonstrate that other mechanisms, such as spike rate adaptation, can fulfill this role. We also analyze the impact of trial-to-trial variability, showing how observational errors as well as neuronal noise result in variability in learned event times. The dynamics of the playback process determines how stochasticity is inherited in learned sequence timings. Future experiments that characterize such variability can therefore shed light on the neural mechanisms of sequence learning.

  15. Silicone breast implants and connective tissue disease

    DEFF Research Database (Denmark)

    Lipworth, Loren; Holmich, Lisbet R; McLaughlin, Joseph K

    2011-01-01

    The association of silicone breast implants with connective tissue diseases (CTDs), including systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and fibromyalgia, as well as a hypothesized new "atypical" disease, which does not meet established diagnostic criteria for any known...

  16. Periodic words connected with the Fibonacci words

    Directory of Open Access Journals (Sweden)

    G. M. Barabash

    2016-06-01

    Full Text Available In this paper we introduce two families of periodic words (FLP-words of type 1 and FLP-words of type 2 that are connected with the Fibonacci words and investigated their properties.

  17. Transistor Effect in Improperly Connected Transistors.

    Science.gov (United States)

    Luzader, Stephen; Sanchez-Velasco, Eduardo

    1996-01-01

    Discusses the differences between the standard representation and a realistic representation of a transistor. Presents an experiment that helps clarify the explanation of the transistor effect and shows why transistors should be connected properly. (JRH)

  18. Non-standard connections in classical mechanics

    CERN Document Server

    Echeverría-Enríquez, A; Román-Roy, N

    1995-01-01

    In the jet-bundle description of first-order classical field theories there are some elements, such as the lagrangian energy and the construction of the hamiltonian formalism, which require the prior choice of a connection. Bearing these facts in mind, we analyze the situation in the jet-bundle description of time-dependent classical mechanics. So we prove that this connection-dependence also occurs in this case, although it is usually hidden by the use of the ``natural'' connection given by the trivial bundle structure of the phase spaces in consideration. However, we also prove that this dependence is dynamically irrelevant, except where the dynamical variation of the energy is concerned. In addition, the relationship between first integrals and connections is shown for a large enough class of lagrangians.

  19. Connecting River Systems Restoration Assessment Degree Flowlines

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This represents the flowline network in Connecting River Systems Restoration Assessment (CRSRA). It is attributed with the number of disconnections between the reach...

  20. PROCESS OF ELECTRICAL CONNECTION OF PHOTOVOLTAIC DEVICES

    DEFF Research Database (Denmark)

    2012-01-01

    A photovoltaic cell module comprising at least two serially connected photovoltaic cells on a common substrate, wherein the cells each comprise a first electrode layer, a first charge selective layer, a light harvesting layer which comprises an organic conjugated polymer, and a second charge...... of the pair, which connection is made through the light harvesting layer common to the at least one pair of cells, without forming an electrical connection with the first electrode of the first cell or the second charge selective layer of the second cell; and a method of making such a photovoltaic cell module....... selective layer that selects for an opposite charge to the first charge selective layer, wherein the first electrode layers for each cell are formed such that the first electrode layer of one cell has no direct electrical connection to the first electrode layer of any other cell, and the second charge...

  1. Children and Place: A Natural Connection.

    Science.gov (United States)

    Vickers, Valerie G.; Matthews, Catherine E.

    2002-01-01

    Presents seven outdoor activities on the environment and ecology to be used at the K-12 grade level. Connects students with the environment they live in and develops the critical sense of place. (Contains 26 references.) (YDS)

  2. Asthma Research: The NIH–NJRC Connection

    Science.gov (United States)

    ... Bar Home Current Issue Past Issues Special Section Asthma Research: The NIH–NJRC Connection Past Issues / Fall ... the many ways that NIH supports and promotes asthma research is through its strong relationship with National ...

  3. Affine connection form of Regge calculus

    CERN Document Server

    Khatsymovsky, V M

    2015-01-01

    Regge action is represented analogously to how the Palatini action for general relativity (GR) as some functional of the metric and a general connection as independent variables represents the Einstein-Hilbert action. The piecewise flat (or simplicial) spacetime of Regge calculus is equipped with some world coordinates and some piecewise affine metric which is completely defined by the set of edge lengths and the world coordinates of the vertices. The conjugate variables are the general nondegenerate matrices on the 3-simplices which play a role of a general discrete connection. Our previous result on some representation of the Regge calculus action in terms of the local Euclidean (Minkowsky) frame vectors and orthogonal connection matrices as independent variables is somewhat modified for the considered case of the general linear group GL(4,R) of the connection matrices. As a result, we have some action invariant w. r. t. arbitrary change of coordinates of the vertices (and related GL(4,R) transformations in...

  4. Application of Partially Connected Neural Network

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    This paper focuses mainly on application of Partially Connected Backpropagation Neural Network (PCBP) instead of typical Fully Connected Neural Network (FCBP). The initial neural network is fully connected, after training with sample data using cross-entropy as error function, a clustering method is employed to cluster weights between inputs to hidden layer and from hidden to output layer, and connections that are relatively unnecessary are deleted, thus the initial network becomes a PCBP network.Then PCBP can be used in prediction or data mining by training PCBP with data that comes from database. At the end of this paper, several experiments are conducted to illustrate the effects of PCBP using Iris data set.

  5. Allele Re-sequencing Technologies

    DEFF Research Database (Denmark)

    Byrne, Stephen; Farrell, Jacqueline Danielle; Asp, Torben

    2013-01-01

    The development of next-generation sequencing technologies has made sequencing an affordable approach for detection of genetic variations associated with various traits. However, the cost of whole genome re-sequencing still remains too high to be feasible for many plant species with large and com...... alternative to whole genome re-sequencing to identify causative genetic variations in plants. One challenge, however, will be efficient bioinformatics strategies for data handling and analysis from the increasing amount of sequence information.......The development of next-generation sequencing technologies has made sequencing an affordable approach for detection of genetic variations associated with various traits. However, the cost of whole genome re-sequencing still remains too high to be feasible for many plant species with large...

  6. Spaces of Ideal Convergent Sequences

    Directory of Open Access Journals (Sweden)

    M. Mursaleen

    2014-01-01

    Full Text Available In the present paper, we introduce some sequence spaces using ideal convergence and Musielak-Orlicz function ℳ=Mk. We also examine some topological properties of the resulting sequence spaces.

  7. Facilitate generation connections on Orkney by automatic distribution network management

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    This report summarises the results of a study assessing the capability and limitations of the Orkney Network under a variety of conditions of demand, generation connections, network configuration, and reactive compensation). A conceptual active management scheme (AMS) suitable for the conditions on Orkney is developed and evaluated. Details are given of a proposed framework for the design and evaluation of future active management schemes, logic control sequences for managed generation units, and a proposed evaluation method for the active management scheme. Implications of introducing the proposed AMS are examined, and the commercial aspects of an AMS and system security are considered. The existing Orkney network is described; and an overview of the SHEPDL (Scottish Hydro Electric Power Distribution Ltd.) SCADA system is presented with a discussion of AMS identification, selection, and development.

  8. Implicit particle methods and their connection with variational data assimilation

    CERN Document Server

    Atkins, Ethan; Chorin, Alexandre J

    2012-01-01

    The implicit particle filter is a sequential Monte Carlo method for data assimilation that guides the particles to the high-probability regions via a sequence of steps that includes minimizations. We present a new and more general derivation of this approach and extend the method to particle smoothing as well as to data assimilation for perfect models. We show that the minimizations required by implicit particle methods are similar to the ones one encounters in variational data assimilation and explore the connection of implicit particle methods with variational data assimilation. In particular, we argue that existing variational codes can be converted into implicit particle methods at a low cost, often yielding better estimates, that are also equipped with quantitative measures of the uncertainty. A detailed example is presented.

  9. Has the connection between polyploidy and diversification actually been tested?

    Science.gov (United States)

    Kellogg, Elizabeth A

    2016-04-01

    Many major clades of angiosperms have several whole genome duplications (polyploidization events) in their distant past, suggesting that polyploidy drives or at least permits diversification. However, data on recently diverged groups are more equivocal, finding little evidence of elevated diversification following polyploidy. The discrepancy may be attributable at least in part to methodology. Many studies use indirect methods, such as chromosome numbers, genome size, and Ks plots, to test polyploidy, although these approaches can be misleading, and often lack sufficient resolution. A direct test of diversification following polyploidy requires a sequence-based approach that traces the history of nuclear genomes rather than species. These methods identify the point of coalescence of ancestral genomes, but may be misleading about the time and thus the extent of diversification. Limitations of existing methods mean that the connection between polyploidy and diversification has not been rigorously tested and remains unknown.

  10. A proof of Connelly's conjecture on 3-connected generic cycles

    DEFF Research Database (Denmark)

    Berg, Alex Rune; Jordán, Tibor

    2001-01-01

    A graph G = (V , E) is called a generic circuit if |E| = 2|V| - 2 and every X ⊂ V with 2 ≥ |X| ≥ |V| - 1 satisfies i(X) ≤ 2|X| - 3. Here i(X) denotes the number of edges induced by X. The operation extension subdivides an edge uw of a graph by a new vertex v and adds a new edge vz for some vertex z...... ≠ u, w. Connelly conjectured that every 3-connected generic circuit can be obtained from K4 by a sequence of extensions. We prove this conjecture. As a corollary, we also obtain a special case of a conjecture of Hendrickson on generically globally rigid graphs....

  11. Better models are more effectively connected models

    Science.gov (United States)

    Nunes, João Pedro; Bielders, Charles; Darboux, Frederic; Fiener, Peter; Finger, David; Turnbull-Lloyd, Laura; Wainwright, John

    2016-04-01

    The concept of hydrologic and geomorphologic connectivity describes the processes and pathways which link sources (e.g. rainfall, snow and ice melt, springs, eroded areas and barren lands) to accumulation areas (e.g. foot slopes, streams, aquifers, reservoirs), and the spatial variations thereof. There are many examples of hydrological and sediment connectivity on a watershed scale; in consequence, a process-based understanding of connectivity is crucial to help managers understand their systems and adopt adequate measures for flood prevention, pollution mitigation and soil protection, among others. Modelling is often used as a tool to understand and predict fluxes within a catchment by complementing observations with model results. Catchment models should therefore be able to reproduce the linkages, and thus the connectivity of water and sediment fluxes within the systems under simulation. In modelling, a high level of spatial and temporal detail is desirable to ensure taking into account a maximum number of components, which then enables connectivity to emerge from the simulated structures and functions. However, computational constraints and, in many cases, lack of data prevent the representation of all relevant processes and spatial/temporal variability in most models. In most cases, therefore, the level of detail selected for modelling is too coarse to represent the system in a way in which connectivity can emerge; a problem which can be circumvented by representing fine-scale structures and processes within coarser scale models using a variety of approaches. This poster focuses on the results of ongoing discussions on modelling connectivity held during several workshops within COST Action Connecteur. It assesses the current state of the art of incorporating the concept of connectivity in hydrological and sediment models, as well as the attitudes of modellers towards this issue. The discussion will focus on the different approaches through which connectivity

  12. Univalent Biharmonic Mappings and Linearly Connected Domains

    Directory of Open Access Journals (Sweden)

    Zayid Abdulhadi

    2015-11-01

    Full Text Available A four times continuously differentiable complex valued function F = u + iv in a simply connected domain Ω is biharmonic if the laplacian of F is harmonic. Every biharmonic mapping F in Ω has the representation F = |z|^2 G + K, where G and K are harmonic in Ω. This paper investigates the relationship between the univalence of F and of K using the concept of linearly connected domains.

  13. SERVIR Town Hall - Connecting Space to Village

    Science.gov (United States)

    Limaye, Ashutosh S.; Searby, Nancy D.; Irwin, Daniel; Albers, Cerese

    2013-01-01

    SERVIR, a joint NASA-USAID project, strives to improve environmental decision making through the use of Earth observations, models, and geospatial technology innovations. SERVIR connects these assets with the needs of end users in Mesoamerica, East Africa, and Hindu Kush-Himalaya regions. This Town Hall meeting will engage the AGU community by exploring examples of connecting Space to Village with SERVIR science applications.

  14. Computational Unification: a Vision for Connecting Researchers

    OpenAIRE

    Troy III, Richard M.

    2004-01-01

    The extent to which the benefits of science can be fully realized depends critically upon the quality of the connection between researchers themselves and between researchers and members of the public. We believe that it is now possible to improve these connections on a community-wide and even world-wide basis through the use of an appropriate information management system. In this paper we explore the concepts and challenges, and propose an architecture for the implementation of such a syste...

  15. Regional Connectivity for Trading in Transport Services

    OpenAIRE

    Dr. M. Rahmatullah

    2012-01-01

    Transport cost, a significant determinant of competitiveness. Due lack of regional connectivity in South Asia and poor trade facilitation at border crossing, logistic costs are 13-14% of the value compared to 8% in USA. Transport connectivities between South Asian countries continue to remain fragmented, despite existence of basic infrastructures Indian wagons come up to the border, and BR Locos pull them inside. No inter-country truck movement. Goods are transshipped at the border.

  16. A critical period for auditory thalamocortical connectivity

    DEFF Research Database (Denmark)

    Rinaldi Barkat, Tania; Polley, Daniel B; Hensch, Takao K

    2011-01-01

    connectivity by in vivo recordings and day-by-day voltage-sensitive dye imaging in an acute brain slice preparation. Passive tone-rearing modified response strength and topography in mouse primary auditory cortex (A1) during a brief, 3-d window, but did not alter tonotopic maps in the thalamus. Gene...... locus of change for the tonotopic plasticity. The evolving postnatal connectivity between thalamus and cortex in the days following hearing onset may therefore determine a critical period for auditory processing....

  17. Zone heated diesel particulate filter electrical connection

    Science.gov (United States)

    Gonze, Eugene V.; Paratore, Jr., Michael J.

    2010-03-30

    An electrical connection system for a particulate filter is provided. The system includes: a particulate filter (PF) disposed within an outer shell wherein the PF is segmented into a plurality of heating zones; an outer mat disposed between the particulate filter and the outer shell; an electrical connector coupled to the outer shell of the PF; and a plurality of printed circuit connections that extend along the outer surface of the PF from the electrical connector to the plurality of heating zones.

  18. Connectivity of Random 1-Dimensional Networks

    OpenAIRE

    Kurlin, V.; Mihaylova, L.

    2007-01-01

    An important problem in wireless sensor networks is to find the minimal number of randomly deployed sensors making a network connected with a given probability. In practice sensors are often deployed one by one along a trajectory of a vehicle, so it is natural to assume that arbitrary probability density functions of distances between successive sensors in a segment are given. The paper computes the probability of connectivity and coverage of 1-dimensional networks and gives estimates for a m...

  19. Strategy of Concurrent Optimization for an Assembly Sequence

    Institute of Scientific and Technical Information of China (English)

    YANG Bo; LIU Lu-ning; ZE Xiang-bo

    2005-01-01

    An effective constraint release based approach to realize concurrent optimization for an assembly sequence is proposed. To quantify the measurement of assembly efficiency, a mathematical model of concurrency evaluation index was put forward at first, and then a technology to quantify assembly constraints was developed by application of some fuzzy logic algorithms. In the process of concurrent optimization of the assembly sequence, two kinds of constraints were involved. One was self-constraints of components, which was used to evaluate the assemble capability of components under the condition of full-freedom. Another was an assembly constraint between components represented by geometric constraints between points, lines and planes under physical restriction conditions. The concept of connection strength degree (CSD) was introduced as one efficient indicator and the value of it was evaluated by the intersection of the two constraints mentioned above. The equivalent constraints describing the connection weights between components were realized by a well designed constraints reduction, and then the connection weights based complete assembly liaison graph was applied to release virtual connections between components. Under a given threshold value, a decomposition and reconstituting strategy for the graph with the focus on high assembly concurrency was used to realize an optimized assembly concurrency evaluation index. Finally, the availability of the approach was illustrated in an example to optimize the assembly of a shift pump.

  20. Sequence Handling by Sequence Analysis Toolbox v1.0

    DEFF Research Database (Denmark)

    Ingrell, Christian Ravnsborg; Matthiesen, Rune; Jensen, Ole Nørregaard

    2006-01-01

    The fact that mass spectrometry have become a high-throughput method calls for bioinformatic tools for automated sequence handling and prediction. For efficient use of bioinformatic tools, it is important that these tools are integrated or interfaced with each other. The purpose of sequence...... analysis toolbox v1.0 was to have a general purpose sequence analyzing tool that can import sequences obtained by high-throughput sequencing methods. The program includes algorithms for calculation or prediction of isoelectric point, hydropathicity index, transmembrane segments, and glycosylphosphatidyl...

  1. Rapid Polymer Sequencer

    Science.gov (United States)

    Stolc, Viktor (Inventor); Brock, Matthew W (Inventor)

    2013-01-01

    Method and system for rapid and accurate determination of each of a sequence of unknown polymer components, such as nucleic acid components. A self-assembling monolayer of a selected substance is optionally provided on an interior surface of a pipette tip, and the interior surface is immersed in a selected liquid. A selected electrical field is impressed in a longitudinal direction, or in a transverse direction, in the tip region, a polymer sequence is passed through the tip region, and a change in an electrical current signal is measured as each polymer component passes through the tip region. Each of the measured changes in electrical current signals is compared with a database of reference electrical change signals, with each reference signal corresponding to an identified polymer component, to identify the unknown polymer component with a reference polymer component. The nanopore preferably has a pore inner diameter of no more than about 40 nm and is prepared by heating and pulling a very small section of a glass tubing.

  2. The Galaxy End Sequence

    CERN Document Server

    Eales, Stephen; Smith, Matthew; Appah, Kiran; Ciesla, Laure; Duffield, Chris; Schofield, Simon

    2016-01-01

    A common assumption is that galaxies fall in two distinct regions on a plot of specific star-formation rate (SSFR) versus galaxy stellar mass: a star-forming Galaxy Main Sequence (GMS) and a separate region of `passive' or `red and dead galaxies'. Starting from a volume-limited sample of nearby galaxies designed to contain most of the stellar mass in this volume, and thus being a fair representation of the Universe at the end of 12 billion years of galaxy evolution, we investigate the distribution of galaxies in this diagram today. We show that galaxies follow a strongly curved extended GMS with a steep negative slope at high galaxy stellar masses. There is a gradual change in the morphologies of the galaxies along this distribution, but there is no clear break between early-type and late-type galaxies. Examining the other evidence that there are two distinct populations, we argue that the `red sequence' is the result of the colours of galaxies changing very little below a critical value of the SSFR, rather t...

  3. Wireless device connection problems and design solutions

    Science.gov (United States)

    Song, Ji-Won; Norman, Donald; Nam, Tek-Jin; Qin, Shengfeng

    2016-09-01

    Users, especially the non-expert users, commonly experience problems when connecting multiple devices with interoperability. While studies on multiple device connections are mostly concentrated on spontaneous device association techniques with a focus on security aspects, the research on user interaction for device connection is still limited. More research into understanding people is needed for designers to devise usable techniques. This research applies the Research-through-Design method and studies the non-expert users' interactions in establishing wireless connections between devices. The "Learning from Examples" concept is adopted to develop a study focus line by learning from the expert users' interaction with devices. This focus line is then used for guiding researchers to explore the non-expert users' difficulties at each stage of the focus line. Finally, the Research-through-Design approach is used to understand the users' difficulties, gain insights to design problems and suggest usable solutions. When connecting a device, the user is required to manage not only the device's functionality but also the interaction between devices. Based on learning from failures, an important insight is found that the existing design approach to improve single-device interaction issues, such as improvements to graphical user interfaces or computer guidance, cannot help users to handle problems between multiple devices. This study finally proposes a desirable user-device interaction in which images of two devices function together with a system image to provide the user with feedback on the status of the connection, which allows them to infer any required actions.

  4. Abnormal asymmetry of brain connectivity in schizophrenia.

    Science.gov (United States)

    Ribolsi, Michele; Daskalakis, Zafiris J; Siracusano, Alberto; Koch, Giacomo

    2014-01-01

    Recently, a growing body of data has revealed that beyond a dysfunction of connectivity among different brain areas in schizophrenia patients (SCZ), there is also an abnormal asymmetry of functional connectivity compared with healthy subjects. The loss of the cerebral torque and the abnormalities of gyrification, with an increased or more complex cortical folding in the right hemisphere may provide an anatomical basis for such aberrant connectivity in SCZ. Furthermore, diffusion tensor imaging studies have shown a significant reduction of leftward asymmetry in some key white-matter tracts in SCZ. In this paper, we review the studies that investigated both structural brain asymmetry and asymmetry of functional connectivity in healthy subjects and SCZ. From an analysis of the existing literature on this topic, we can hypothesize an overall generally attenuated asymmetry of functional connectivity in SCZ compared to healthy controls. Such attenuated asymmetry increases with the duration of the disease and correlates with psychotic symptoms. Finally, we hypothesize that structural deficits across the corpus callosum may contribute to the abnormal asymmetry of intra-hemispheric connectivity in schizophrenia.

  5. Admissibility, stable units and connected components

    CERN Document Server

    Xarez, J J

    2011-01-01

    Consider a reflection from a finitely-complete category $\\mathbb{C}$ into its full subcategory $\\mathbb{M}$, with unit $\\eta :1_\\mathbb{C}\\rightarrow HI$. Suppose there is a left-exact functor $U$ into the category of sets, such that $UH$ reflects isomorphisms and $U(\\eta_C)$ is a surjection, for every $C\\in\\mathbb{C}$. If, in addition, all the maps $\\mathbb{M}(T,M)\\rightarrow \\mathbf{Set}(1,U(M))$ induced by the functor $UH$ are surjections, where $T$ and 1 are respectively terminal objects in $\\mathbb{C}$ and $\\mathbf{Set}$, for every object $M$ in the full subcategory $\\mathbb{M}$, then it is true that: the reflection $H\\vdash I$ is semi-left-exact (admissible in the sense of categorical Galois theory) if and only if its connected components are "connected"; it has stable units if and only if any finite product of connected components is "connected". Where the meaning of "connected" is the usual in categorical Galois theory, and the definition of connected component with respect to the ground structure wil...

  6. Modulation of frontal effective connectivity during speech.

    Science.gov (United States)

    Holland, Rachel; Leff, Alex P; Penny, William D; Rothwell, John C; Crinion, Jenny

    2016-10-15

    Noninvasive neurostimulation methods such as transcranial direct current stimulation (tDCS) can elicit long-lasting, polarity-dependent changes in neocortical excitability. In a previous concurrent tDCS-fMRI study of overt picture naming, we reported significant behavioural and regionally specific neural facilitation effects in left inferior frontal cortex (IFC) with anodal tDCS applied to left frontal cortex (Holland et al., 2011). Although distributed connectivity effects of anodal tDCS have been modelled at rest, the mechanism by which 'on-line' tDCS may modulate neuronal connectivity during a task-state remains unclear. Here, we used Dynamic Causal Modelling (DCM) to determine: (i) how neural connectivity within the frontal speech network is modulated during anodal tDCS; and, (ii) how individual variability in behavioural response to anodal tDCS relates to changes in effective connectivity strength. Results showed that compared to sham, anodal tDCS elicited stronger feedback from inferior frontal sulcus (IFS) to ventral premotor (VPM) accompanied by weaker self-connections within VPM, consistent with processes of neuronal adaptation. During anodal tDCS individual variability in the feedforward connection strength from IFS to VPM positively correlated with the degree of facilitation in naming behaviour. These results provide an essential step towards understanding the mechanism of 'online' tDCS paired with a cognitive task. They also identify left IFS as a 'top-down' hub and driver for speech change.

  7. Novel sequences propel familiar folds.

    Science.gov (United States)

    Jawad, Zahra; Paoli, Massimo

    2002-04-01

    Recent structure determinations have made new additions to a set of strikingly different sequences that give rise to the same topology. Proteins with a beta propeller fold are characterized by extreme sequence diversity despite the similarity in their three-dimensional structures. Several fold predictions, based in part on sequence repeats thought to match modular beta sheets, have been proved correct.

  8. Methods of solving sequence and series problems

    CERN Document Server

    Grigorieva, Ellina

    2016-01-01

    This book aims to dispel the mystery and fear experienced by students surrounding sequences, series, convergence, and their applications. The author, an accomplished female mathematician, achieves this by taking a problem solving approach, starting with fascinating problems and solving them step by step with clear explanations and illuminating diagrams. The reader will find the problems interesting, unusual, and fun, yet solved with the rigor expected in a competition. Some problems are taken directly from mathematics competitions, with the name and year of the exam provided for reference. Proof techniques are emphasized, with a variety of methods presented. The text aims to expand the mind of the reader by often presenting multiple ways to attack the same problem, as well as drawing connections with different fields of mathematics. Intuitive and visual arguments are presented alongside technical proofs to provide a well-rounded methodology. With nearly 300 problems including hints, answers, and solutions,Met...

  9. Regularities in the E.coli promoters composition in connection with the DNA strands interaction and promoter activity

    Institute of Scientific and Technical Information of China (English)

    BEREZHNOY Andrey Yu; SHCKORBATOV Yuriy G.; HISANORI Kiryu

    2006-01-01

    The energy of interaction between DNA strands in promoters is of great functional importance. Visualization of the energy of DNA strands distribution in promoter sequences was achieved. The separation of promoters in groups by their energetic properties enables evaluation of the dependence of promoter strength on the energetic properties. The analysis of groups (clusters)of promoters distributed by the energy of DNA strands interaction in -55, -35, -10 and +6 sequences indicates their connection with the transcriptional activity.

  10. Limited Genetic Connectivity between Gorgonian Morphotypes along a Depth Gradient.

    Science.gov (United States)

    Costantini, Federica; Gori, Andrea; Lopez-González, Pablo; Bramanti, Lorenzo; Rossi, Sergio; Gili, Josep-Maria; Abbiati, Marco

    2016-01-01

    Gorgonian species show a high morphological variability in relation to the environment in which they live. In coastal areas, parameters such as temperature, light, currents, and food availability vary significantly with depth, potentially affecting morphology of the colonies and the structure of the populations, as well as their connectivity patterns. In tropical seas, the existence of connectivity between shallow and deep populations supported the hypothesis that the deep coral reefs could potentially act as (reproductive) refugia fostering re-colonization of shallow areas after mortality events. Moreover, this hypothesis is not so clear accepted in temperate seas. Eunicella singularis is one of the most common gorgonian species in Northwestern Mediterranean Sea, playing an important role as ecosystem engineer by providing biomass and complexity to the coralligenous habitats. It has a wide bathymetric distribution ranging from about 10 m to 100 m. Two depth-related morphotypes have been identified, differing in colony morphology, sclerite size and shape, and occurrence of symbiotic algae, but not in mitochondrial DNA haplotypes. In the present study the genetic structure of E. singularis populations along a horizontal and bathymetric gradient was assessed using microsatellites and ITS1 sequences. Restricted gene flow was found at 30-40 m depth between the two Eunicella morphotypes. Conversely, no genetic structuring has been found among shallow water populations within a spatial scale of ten kilometers. The break in gene flow between shallow and deep populations contributes to explain the morphological variability observed at different depths. Moreover, the limited vertical connectivity hinted that the refugia hypothesis does not apply to E. singularis. Re-colonization of shallow water populations, occasionally affected by mass mortality events, should then be mainly fueled by larvae from other shallow water populations.

  11. Partition-induced connections and operators for pattern analysis

    NARCIS (Netherlands)

    Ouzounis, Georgios K.; Wilkinson, Michael H.F.

    2010-01-01

    In this paper we present a generalization on the notion of image connectivity similar to that modeled by second-generation connections. The connected operators based on this new type of connection make use of image partitions aided by mask images to extract path-wise connected regions that were prev

  12. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

    Science.gov (United States)

    Shibata, K; Itoh, M; Aizawa, K; Nagaoka, S; Sasaki, N; Carninci, P; Konno, H; Akiyama, J; Nishi, K; Kitsunai, T; Tashiro, H; Itoh, M; Sumi, N; Ishii, Y; Nakamura, S; Hazama, M; Nishine, T; Harada, A; Yamamoto, R; Matsumoto, H; Sakaguchi, S; Ikegami, T; Kashiwagi, K; Fujiwake, S; Inoue, K; Togawa, Y

    2000-11-01

    The RIKEN high-throughput 384-format sequencing pipeline (RISA system) including a 384-multicapillary sequencer (the so-called RISA sequencer) was developed for the RIKEN mouse encyclopedia project. The RISA system consists of colony picking, template preparation, sequencing reaction, and the sequencing process. A novel high-throughput 384-format capillary sequencer system (RISA sequencer system) was developed for the sequencing process. This system consists of a 384-multicapillary auto sequencer (RISA sequencer), a 384-multicapillary array assembler (CAS), and a 384-multicapillary casting device. The RISA sequencer can simultaneously analyze 384 independent sequencing products. The optical system is a scanning system chosen after careful comparison with an image detection system for the simultaneous detection of the 384-capillary array. This scanning system can be used with any fluorescent-labeled sequencing reaction (chain termination reaction), including transcriptional sequencing based on RNA polymerase, which was originally developed by us, and cycle sequencing based on thermostable DNA polymerase. For long-read sequencing, 380 out of 384 sequences (99.2%) were successfully analyzed and the average read length, with more than 99% accuracy, was 654.4 bp. A single RISA sequencer can analyze 216 kb with >99% accuracy in 2.7 h (90 kb/h). For short-read sequencing to cluster the 3' end and 5' end sequencing by reading 350 bp, 384 samples can be analyzed in 1.5 h. We have also developed a RISA inoculator, RISA filtrator and densitometer, RISA plasmid preparator which can handle throughput of 40,000 samples in 17.5 h, and a high-throughput RISA thermal cycler which has four 384-well sites. The combination of these technologies allowed us to construct the RISA system consisting of 16 RISA sequencers, which can process 50,000 DNA samples per day. One haploid genome shotgun sequence of a higher organism, such as human, mouse, rat, domestic animals, and plants, can be

  13. Logging Data High-Resolution Sequence Stratigraphy

    Institute of Scientific and Technical Information of China (English)

    Li Hongqi; Xie Yinfu; Sun Zhongchun; Luo Xingping

    2006-01-01

    The recognition and contrast of bed sets in parasequence is difficult in terrestrial basin high-resolution sequence stratigraphy. This study puts forward new methods for the boundary identification and contrast of bed sets on the basis of manifold logging data. The formation of calcareous interbeds, shale resistivity differences and the relation of reservoir resistivity to altitude are considered on the basis of log curve morphological characteristics, core observation, cast thin section, X-ray diffraction and scanning electron microscopy. The results show that the thickness of calcareous interbeds is between 0.5 m and 2 m, increasing on weathering crusts and faults. Calcareous interbeds occur at the bottom of Reservoir resistivity increases with altitude. Calcareous interbeds may be a symbol of recognition for the boundary of bed sets and isochronous contrast bed sets, and shale resistivity differences may confirm the stack relation and connectivity of bed sets. Based on this, a high-rcsolution chronostratigraphic framework of Xi-1 segment in Shinan area, Junggar basin is presented, and the connectivity of bed sets and oil-water contact is confirmed. In this chronostratigraphic framework, the growth order, stack mode and space shape of bed sets are qualitatively and quantitatively described.

  14. Reflections on the specificity of synaptic connections.

    Science.gov (United States)

    White, Edward L

    2007-10-01

    The principal focus of this treatise is the specificity of synaptic connectivity in the mammalian central nervous system. The occurrence of stereotypical patterns of connection at the macro level (e.g., the general consistency with which axonal pathways impinge on and originate within specific cortical areas and layers) implies that the cerebral cortex is a highly ordered structure. Order is seen also at the more micro level of synaptic connectivity, for instance, in the contrasting synaptic patterns of spiny vs. non-spiny neurons. Quantitative electron microscopic studies of synapses between identified neurons and correlative anatomical/electrophysiological investigations indicate that the high degree of order characterizing many aspects of cortical organization is mirrored by an equally ordered arrangement of synaptic connections between specific types of neurons. The recognition of recurring synaptic patterns has generated increased support for the notion of synaptic specificity as opposed to randomness, and we have begun now to understand the role of specificity in cortical function. At the core of cortical processing lie myriad possibilities for computation provided by the wealth of synaptic connections involving each neuron. Specificity, by limiting possibilities for connection, imposes an order on synaptic interactions even as processes of dynamic selection or synaptic remodeling ensure the constant formation and dissolution of cortical circuits. Collectively, these operations make maximal use of the richness of cortical synaptic connections to produce a highly flexible system, irrespective of the degree of hard-wiring, mutability, randomness or specificity that obtains for cortical wiring at any particular time. A brief, historical account of developments leading to our current understanding of cortical synaptic organization will precede the presentation of evidence for synaptic specificity.

  15. Connectivity measures in EEG microstructural sleep elements

    Directory of Open Access Journals (Sweden)

    Dimitris eSakellariou

    2016-02-01

    Full Text Available During Non-Rapid Eye Movement sleep (NREM the brain is relatively disconnected from the environment, while connectedness between brain areas is also decreased. Evidence indicates that these dynamic connectivity changes are delivered by microstructural elements of sleep: short periods of environmental stimuli evaluation followed by sleep promoting procedures. The connectivity patterns of the latter, among other aspects of sleep microstructure, are still to be fully elucidated.We suggest here a methodology for the assessment and investigation of the connectivity patterns of EEG microstructural elements, such as sleep spindles. The methodology combines techniques in the preprocessing, estimation, error assessing and visualization of results levels in order to allow the detailed examination of the connectivity aspects (levels and directionality of information flow over frequency and time with notable resolution, while dealing with the volume conduction and EEG reference assessment. The high temporal and frequency resolution of the methodology will allow the association between the microelements and the dynamically forming networks that characterise them, and consequently possibly reveal aspects of the EEG microstructure. The proposed methodology is initially tested on artificially generated signals for proof of concept and subsequently applied to real EEG recordings via a custom built MATLAB-based tool developed for such studies. Preliminary results from 843 fast sleep spindles recorded in whole night sleep of 5 healthy volunteers indicate a prevailing pattern of interactions between centroparietal and frontal regions.We demonstrate hereby an opening to our knowledge attempt to estimate the scalp EEG connectivity that characterizes fast sleep spindles via an EEG-element connectivity methodology we propose. The application of the latter, via a computational tool we developed suggests it is able to investigate the connectivity patterns related to the

  16. Solid phase sequencing of biopolymers

    Energy Technology Data Exchange (ETDEWEB)

    Cantor, Charles (Del Mar, CA); Koster, Hubert (La Jolla, CA)

    2010-09-28

    This invention relates to methods for detecting and sequencing target nucleic acid sequences, to mass modified nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involve hybridizing the nucleic acids or nucleic acids which represent complementary or homologous sequences of the target to an array of nucleic acid probes. These probes comprise a single-stranded portion, an optional double-stranded portion and a variable sequence within the single-stranded portion. The molecular weights of the hybridized nucleic acids of the set can be determined by mass spectroscopy, and the sequence of the target determined from the molecular weights of the fragments. Nucleic acids whose sequences can be determined include DNA or RNA in biological samples such as patient biopsies and environmental samples. Probes may be fixed to a solid support such as a hybridization chip to facilitate automated molecular weight analysis and identification of the target sequence.

  17. Registering cortical surfaces based on whole-brain structural connectivity and continuous connectivity analysis.

    Science.gov (United States)

    Gutman, Boris; Leonardo, Cassandra; Jahanshad, Neda; Hibar, Derrek; Eschenburg, Kristian; Nir, Talia; Villalon, Julio; Thompson, Paul

    2014-01-01

    We present a framework for registering cortical surfaces based on tractography-informed structural connectivity. We define connectivity as a continuous kernel on the product space of the cortex, and develop a method for estimating this kernel from tractography fiber models. Next, we formulate the kernel registration problem, and present a means to non-linearly register two brains' continuous connectivity profiles. We apply theoretical results from operator theory to develop an algorithm for decomposing the connectome into its shared and individual components. Lastly, we extend two discrete connectivity measures to the continuous case, and apply our framework to 98 Alzheimer's patients and controls. Our measures show significant differences between the two groups.

  18. Wetland Hydrological Connectivity: A Classification Approach and Continental Assessment

    Science.gov (United States)

    Connectivity has become a major focus of hydrological and ecological studies. Connectivity influences fluxes between landscape elements, while isolation reduces flows between elements. Thus connectivity can be an important characteristic controlling ecosystem services. Hydrolo...

  19. k-Connectivity of Random Key Graphs

    CERN Document Server

    Zhao, Jun; Gligor, Virgil

    2015-01-01

    Random key graphs represent topologies of secure wireless sensor networks that apply the seminal Eschenauer-Gligor random key predistribution scheme to secure communication between sensors. These graphs have received much attention and also been used in diverse application areas beyond secure sensor networks; e.g., cryptanalysis, social networks, and recommender systems. Formally, a random key graph with $n$ nodes is constructed by assigning each node $X_n$ keys selected uniformly at random from a pool of $Y_n$ keys and then putting an undirected edge between any two nodes sharing at least one key. Considerable progress has been made in the literature to analyze connectivity and $k$-connectivity of random key graphs, where $k$-connectivity of a graph ensures connectivity even after the removal of $k$ nodes or $k$ edges. Yet, it still remains an open question for $k$-connectivity in random key graphs under $X_n \\geq 2$ and $X_n = o(\\sqrt{\\ln n})$ (the case of $X_n=1$ is trivial). In this paper, we answer the a...

  20. Affine connection form of Regge calculus

    Science.gov (United States)

    Khatsymovsky, V. M.

    2016-12-01

    Regge action is represented analogously to how the Palatini action for general relativity (GR) as some functional of the metric and a general connection as independent variables represents the Einstein-Hilbert action. The piecewise flat (or simplicial) spacetime of Regge calculus is equipped with some world coordinates and some piecewise affine metric which is completely defined by the set of edge lengths and the world coordinates of the vertices. The conjugate variables are the general nondegenerate matrices on the three-simplices which play the role of a general discrete connection. Our previous result on some representation of the Regge calculus action in terms of the local Euclidean (Minkowsky) frame vectors and orthogonal connection matrices as independent variables is somewhat modified for the considered case of the general linear group GL(4, R) of the connection matrices. As a result, we have some action invariant w.r.t. arbitrary change of coordinates of the vertices (and related GL(4, R) transformations in the four-simplices). Excluding GL(4, R) connection from this action via the equations of motion we have exactly the Regge action for the considered spacetime.

  1. A systematic framework for functional connectivity measures

    Directory of Open Access Journals (Sweden)

    Huifang Elizabeth Wang

    2014-12-01

    Full Text Available Various methods have been proposed to characterize the functional connectivity between nodes in a network measured with different modalities (electrophysiology, functional magnetic resonance imaging etc.. Since different measures of functional connectivity yield different results for the same dataset, it is important to assess when and how they can be used. In this work, we provide a systematic framework for evaluating the performance of a large range of functional connectivity measures – based upon a comprehensive portfolio of models generating measurable responses. Specifically, we benchmarked 42 methods using 10,000 simulated datasets from 5 different types of generative models with different connectivity structures. Since all functional connectivity methods require the setting of some parameters (window size and number, model order etc., we first optimized these parameters using performance criteria based upon (threshold free ROC analysis. We then evaluated the performance of the methods on data simulated with different types of models. Finally, we assessed the performance of the methods against different levels of signal-to-noise ratios and network configurations. A MATLAB toolbox is provided to perform such analyses using other methods and simulated datasets.

  2. Connected Car: Quantified Self becomes Quantified Car

    Directory of Open Access Journals (Sweden)

    Melanie Swan

    2015-02-01

    Full Text Available The automotive industry could be facing a situation of profound change and opportunity in the coming decades. There are a number of influencing factors such as increasing urban and aging populations, self-driving cars, 3D parts printing, energy innovation, and new models of transportation service delivery (Zipcar, Uber. The connected car means that vehicles are now part of the connected world, continuously Internet-connected, generating and transmitting data, which on the one hand can be helpfully integrated into applications, like real-time traffic alerts broadcast to smartwatches, but also raises security and privacy concerns. This paper explores the automotive connected world, and describes five killer QS (Quantified Self-auto sensor applications that link quantified-self sensors (sensors that measure the personal biometrics of individuals like heart rate and automotive sensors (sensors that measure driver and passenger biometrics or quantitative automotive performance metrics like speed and braking activity. The applications are fatigue detection, real-time assistance for parking and accidents, anger management and stress reduction, keyless authentication and digital identity verification, and DIY diagnostics. These kinds of applications help to demonstrate the benefit of connected world data streams in the automotive industry and beyond where, more fundamentally for human progress, the automation of both physical and now cognitive tasks is underway.

  3. Data repository mapping for influenza protein sequence analysis

    Science.gov (United States)

    Pellegrino, Donald; Chen, Chaomei

    2011-01-01

    This paper introduces a new method for creating an interactive sequence similarity map of all known influenza virus protein sequences and integrating the map with existing general purpose analytical tools. The NCBI data model was designed to provide a high degree of interconnectedness amongst data objects. Substantial and continuous increase in data volume has led to a large and highly connected information space. Researchers seeking to explore this space are challenged to identify a starting point. They often choose data that is popular in the literature. Reference in the literature follow a power law distribution and popular data points may bias explorers toward paths that lead only to a dead-end of what is already known. To help discover the unexpected we developed an interactive visual analytics system to map the information space of influenza protein sequence data. The design is motivated by the needs of eScience researchers.

  4. P-connection on Riemannian almost product manifolds

    CERN Document Server

    Mekerov, Dimitar

    2009-01-01

    In the present work, we introduce a linear connection (preserving the almost product structure and the Riemannian metric) on Riemannian almost product manifolds. This connection, called P-connection, is an analogue of the first canonical connection of Lichnerowicz in the Hermitian geometry and the B-connection in the geometry of the almost complex manifolds with Norden metric. Particularly, we consider the P-connection on a the class of manifolds with nonintegrable almost product structure.

  5. Sequencing the exposome: A call to action

    Directory of Open Access Journals (Sweden)

    Dean P. Jones

    2016-01-01

    Full Text Available The exposome is a complement to the genome that includes non-genetic causes of disease. Multiple definitions are available, with salient points being global inclusion of exposures and behaviors, and cumulative integration of associated biologic responses. As such, the concept is both refreshingly simple and dauntingly complex. This article reviews high-resolution metabolomics (HRM as an affordable approach to routinely analyze samples for a broad spectrum of environmental chemicals and biologic responses. HRM has been successfully used in multiple exposome research paradigms and is suitable to implement in a prototype universal exposure surveillance system. Development of such a structure for systematic monitoring of environmental exposures is an important step toward sequencing the exposome because it builds upon successes of exposure science, naturally connects external exposure to body burden and partitions the exposome into workable components. Practical results would be repositories of quantitative data on chemicals according to geography and biology. This would support new opportunities for environmental health analysis and predictive modeling. Complementary approaches to hasten development of exposome theory and associated biologic response networks could include experimental studies with model systems, analysis of archival samples from longitudinal studies with outcome data and study of relatively short-lived animals, such as household pets (dogs and cats and non-human primates (common marmoset. International investment and cooperation to sequence the human exposome will advance scientific knowledge and also provide an important foundation to control adverse environmental exposures to sustain healthy living spaces and improve prediction and management of disease.

  6. Sequential evolution of cortical activity and effective connectivity of swallowing using fMRI.

    Science.gov (United States)

    Mihai, Paul Glad; Otto, Mareile; Platz, Thomas; Eickhoff, Simon B; Lotze, Martin

    2014-12-01

    Swallowing consists of a hierarchical sequence of primary motor and somatosensory processes. The temporal interplay of different phases is complex and clinical disturbances frequent. Of interest was the temporal interaction of the swallowing network. Time resolution optimized functional magnetic resonance imaging was used to describe the temporal sequence of representation sites of swallowing and their functional connectivity. Sixteen young healthy volunteers were investigated who swallowed 2 ml of water 20 times per run with a repetition time for functional imaging of 514 ms. After applying the general linear model approach to identify activation magnitude in preselected regions of interest repeated measures analysis of variance (rmANOVA) was used to detect relevant effects on lateralization, time, and onset. Furthermore, dynamic causal modeling (DCM) was applied to uncover where the input enters the model and the way in which the cortical regions are connected. The temporal analysis revealed a successive activation starting at the premotor cortex, supplementary motor area (SMA), and bilateral thalamus, followed by the primary sensorimotor cortex, the posterior insula, and cerebellum and culminating with activation in the pons shortly before subsiding. The rmANOVA revealed that activation was lateralized initially to the left hemisphere and gradually moved to the right hemisphere over time. The group random effects DCM analysis resulted in a most likely model that consisted of inputs to SMA and M1S1, bidirectionally connected, and a one-way connection from M1S1 to the posterior insula.

  7. Evolution Strategies in the Multipoint Connections Routing

    Directory of Open Access Journals (Sweden)

    L. Krulikovska

    2010-09-01

    Full Text Available Routing of multipoint connections plays an important role in final cost and quality of a found connection. New algorithms with better results are still searched. In this paper, a possibility of using the evolution strategies (ES for routing is presented. Quality of found connection is evaluated from the view of final cost and time spent on a searching procedure. First, parametrical analysis of results of the ES are discussed and compared with the Prim’s algorithm, which was chosen as a representative of the deterministic routing algorithms. Second, ways for improving the ES are suggested and implemented. The obtained results are reviewed. The main improvements are specified and discussed in conclusion.

  8. Quantifying Riverscape Connectivity with Graph Theory

    Science.gov (United States)

    Carbonneau, P.; Milledge, D.; Sinha, R.; Tandon, S. K.

    2013-12-01

    Fluvial catchments convey fluxes of water, sediment, nutrients and aquatic biota. At continental scales, crustal topography defines the overall path of channels whilst at local scales depositional and/or erosional features generally determine the exact path of a channel. Furthermore, constructions such as dams, for either water abstraction or hydropower, often have a significant impact on channel networks.The concept of ';connectivity' is commonly invoked when conceptualising the structure of a river network.This concept is easy to grasp but there have been uneven efforts across the environmental sciences to actually quantify connectivity. Currently there have only been a few studies reporting quantitative indices of connectivity in river sciences, notably, in the study of avulsion processes. However, the majority of current work describing some form of environmental connectivity in a quantitative manner is in the field of landscape ecology. Driven by the need to quantify habitat fragmentation, landscape ecologists have returned to graph theory. Within this formal setting, landscape ecologists have successfully developed a range of indices which can model connectivity loss. Such formal connectivity metrics are currently needed for a range of applications in fluvial sciences. One of the most urgent needs relates to dam construction. In the developed world, hydropower development has generally slowed and in many countries, dams are actually being removed. However, this is not the case in the developing world where hydropower is seen as a key element to low-emissions power-security. For example, several dam projects are envisaged in Himalayan catchments in the next 2 decades. This region is already under severe pressure from climate change and urbanisation, and a better understanding of the network fragmentation which can be expected in this system is urgently needed. In this paper, we apply and adapt connectivity metrics from landscape ecology. We then examine the

  9. Connections with nature and environmental behaviors.

    Science.gov (United States)

    Geng, Liuna; Xu, Jingke; Ye, Lijuan; Zhou, Wenjun; Zhou, Kexin

    2015-01-01

    The influence of environmental attitudes on environmental behaviors has long been discussed. However, few studies have addressed the foundation of such attitudes. In the present study, we explored primitive belief underlying environmental attitudes, i.e., connections with nature, and its relationship with pro-environmental behaviors. Specifically, we used scales, a computerized Implicit Association Test, and a situational simulation experiment to examine both explicit and implicit connections with nature, both deliberate and spontaneous environmental behaviors, and to find correlations between environmental connectedness and environmental behaviors. Results showed that explicit connectedness was positively correlated with deliberate environmental behaviors, while implicit connectedness was positively correlated with spontaneous environmental behaviors. Additionally, explicit and implicit connectedness was independent of each other. In conclusion, the current study confirms the positive role played by connections with nature in promoting environmental behavior, and accordingly suggests means to encourage pro-environmental behavior by enhancing people's connectedness to nature.

  10. AMTEC vapor-vapor series connected cells

    Science.gov (United States)

    Underwood, Mark L.; Williams, Roger M.; Ryan, Margaret A.; Nakamura, Barbara J.; Oconnor, Dennis E.

    1995-08-01

    An alkali metal thermoelectric converter (AMTEC) having a plurality of cells structurally connected in series to form a septum dividing a plenum into two chambers, and electrically connected in series, is provided with porous metal anodes and porous metal cathodes in the cells. The cells may be planar or annular, and in either case a metal alkali vapor at a high temperature is provided to the plenum through one chamber on one side of the wall and returned to a vapor boiler after condensation at a chamber on the other side of the wall in the plenum. If the cells are annular, a heating core may be placed along the axis of the stacked cells. This arrangement of series-connected cells allows efficient generation of power at high voltage and low current.

  11. Connective Versus Collective Action in Social Movements

    DEFF Research Database (Denmark)

    Lundgaard, Daniel; Razmerita, Liana

    ). This process is influenced by two dynamics; the logic of collective action and the logic of connective action (Bennett & Segerberg, 2012). The logic of collective action is defined by formal organizational control, stronger commitment and collective identity framing (Bennett & Segerberg 2012). The logic...... of connective action is are sult of mediating technologies especially web 2.0 that inspire and affords emergent digitally networked action, based on large‐scale self‐organized, fluid and weak‐tied networks (Ibid.). These logics are investigated in three different social media movements; #YesAllWomen, #Black......LivesMatter and the #IceBucketChallenge by analyzing Twitter and Facebook data from key periods of these movements,through a net nographic study. In particular, this study has investigated the following research questions: How are the logics of collective and connective action reflected in online social media interactions...

  12. Healthcare e-commerce: connecting with patients.

    Science.gov (United States)

    Joslyn, J S

    2001-01-01

    Electronically connecting with patients is a challenging frontier at which technical hurdles are probably exceeded by political, legal, and other barriers. The rise of consumerism, however, compels a response focused more on revenue and strategic advantage than on pure cost savings. Among the difficulties faced by providers is choosing among various models of connectivity and component function. Emerging models include "free-floating" personal medical records largely independent of the office-based physician, systems with compatible and intertwined physician and consumer relationships using an application services provider office practice system, and systems that connect patients and providers through e-mail, office triage, prescription refills, scheduling, and so on. This article discusses these and other combinations of technology that significantly overcome the barriers involved and that may be woven together to provide solutions uniquely suited to various competitive situations.

  13. LR: Compact connectivity representation for triangle meshes

    Energy Technology Data Exchange (ETDEWEB)

    Gurung, T; Luffel, M; Lindstrom, P; Rossignac, J

    2011-01-28

    We propose LR (Laced Ring) - a simple data structure for representing the connectivity of manifold triangle meshes. LR provides the option to store on average either 1.08 references per triangle or 26.2 bits per triangle. Its construction, from an input mesh that supports constant-time adjacency queries, has linear space and time complexity, and involves ordering most vertices along a nearly-Hamiltonian cycle. LR is best suited for applications that process meshes with fixed connectivity, as any changes to the connectivity require the data structure to be rebuilt. We provide an implementation of the set of standard random-access, constant-time operators for traversing a mesh, and show that LR often saves both space and traversal time over competing representations.

  14. Design of Bolted L-Flanged Connections

    DEFF Research Database (Denmark)

    Pedersen, Niels Leergaard

    2016-01-01

    on the tower and the tensile force in the bolt. In the literature and also in design standards different models are presented for this important non-linear response. The present work presents a simplified expression for the non-linear force response based on finite element calculations using contact analysis......In wind turbine towers the preferred design is circular tubes that are connected to each other by a bolted flange joint. The design is typically that of an L-flange resulting in an eccentrically loaded bolted connection. The eccentricity results in a non-linear relationship between external load....... Secondly, focus is on simple modifications of the flange design that considerably improves the strength of the connection....

  15. Political Connections and Investment in Rural Vietnam

    DEFF Research Database (Denmark)

    Markussen, Thomas; Tarp, Finn

    as a result of relatives moving into public office. Connections to office holders appear to be important for investment because they strengthen de facto land property rights and improve access to off-farm employment and to informal loans. The findings underline the importance of informal networks for economic......This paper uses household panel data from rural Vietnam to explore the effects of having a relative in a position of political or bureaucratic power on farmers’ agricultural investment decisions. Our main result is that households significantly increase their investment in land improvement...... behaviour in environments with developing institutions and markets. They also suggest the presence of an untapped potential for economic development: if households without connections could obtain equally strong property rights and access to credit and insurance as the well-connected households, investment...

  16. Altered Functional Connectivity in Essential Tremor

    Science.gov (United States)

    Benito-León, Julián; Louis, Elan D.; Romero, Juan Pablo; Hernández-Tamames, Juan Antonio; Manzanedo, Eva; Álvarez-Linera, Juan; Bermejo-Pareja, Félix; Posada, Ignacio; Rocon, Eduardo

    2015-01-01

    Abstract Essential tremor (ET) has been associated with a spectrum of clinical features, with both motor and nonmotor elements, including cognitive deficits. We employed resting-state functional magnetic resonance imaging (fMRI) to assess whether brain networks that might be involved in the pathogenesis of nonmotor manifestations associated with ET are altered, and the relationship between abnormal connectivity and ET severity and neuropsychological function. Resting-state fMRI data in 23 ET patients (12 women and 11 men) and 22 healthy controls (HC) (12 women and 10 men) were analyzed using independent component analysis, in combination with a “dual-regression” technique, to identify the group differences of resting-state networks (RSNs) (default mode network [DMN] and executive, frontoparietal, sensorimotor, cerebellar, auditory/language, and visual networks). All participants underwent a neuropsychological and neuroimaging session, where resting-state data were collected. Relative to HC, ET patients showed increased connectivity in RSNs involved in cognitive processes (DMN and frontoparietal networks) and decreased connectivity in the cerebellum and visual networks. Changes in network integrity were associated not only with ET severity (DMN) and ET duration (DMN and left frontoparietal network), but also with cognitive ability. Moreover, in at least 3 networks (DMN and frontoparietal networks), increased connectivity was associated with worse performance on different cognitive domains (attention, executive function, visuospatial ability, verbal memory, visual memory, and language) and depressive symptoms. Further, in the visual network, decreased connectivity was associated with worse performance on visuospatial ability. ET was associated with abnormal brain connectivity in major RSNs that might be involved in both motor and nonmotor symptoms. Our findings underscore the importance of examining RSNs in this population as a biomarker of disease. PMID:26656325

  17. Functional connectivity of emotional processing in depression.

    LENUS (Irish Health Repository)

    Carballedo, Angela

    2012-02-01

    OBJECTIVES: The aim of the study is to map a neural network of emotion processing and to identify differences in major depression compared to healthy controls. It is hypothesized that intentional perception of emotional faces activates connections between amygdala (Demir et al.), orbitofrontal cortex (OFC), anterior cingulate cortex (ACC) and prefrontal cortex (PFC) and that frontal-amygdala connections are altered in major depressive disorder (MDD). METHODS: Fifteen medication-free patients with MDD and fifteen healthy controls were enrolled. All subjects were assessed using the same face-matching functional Magnetic Resonance Imaging (fMRI) task, known to involve those areas. Brain activations were obtained using Statistical Parametric Mapping version 5 (SPM5) for data analysis and MARSBAR for extracting of fMRI time series. Then data was analyzed using structural equation modeling (SEM). RESULTS: A valid model was established for the left and the right hemispheres showing a circuit involving ACC, OFC, PFC and AMY. The left hemisphere shows significant lower connectivity strengths in patients than controls, for the pathway that goes from AMY to the OF11, and a trend of higher connectivity in patients for the path that goes from the PF9 to the OF11. In the right hemisphere, patients show lower connectivity coefficients in the paths from the AMY to OF11, from the AMY to ACC, and from the ACC to PF9. By the contrary, controls show lower connectivity strengths for the path that goes from ACC to AMY. CONCLUSIONS: Functional disconnection between limbic and frontal brain regions could be demonstrated using structural equation modeling. The interpretation of these findings could be that there is an emotional processing bias with disconnection bilaterally between amygdala to orbitofrontal cortices and in addition a right disconnection between amygdala and ACC as well as between ACC and prefrontal cortex possibly in line with a more prominent role for the right hemisphere

  18. AARP iPad Tech to Connect

    CERN Document Server

    Boyd, Barbara

    2012-01-01

    The world is at your fingertips with iPad! AARP iPad: Tech to Connect introduces you to the world?s most popular tablet device, the iPad, and all the amazing things it has to offer. In clear, non-technical language, this book guides you through registering and setting up your iPad, getting acquainted with the multitouch interface, navigating around the screen, finding and downloading apps, reading books, listening to music, watching videos, surfing the web, and communicating with friends and family. Developed in partnership with AARP and dedicated to helping readers stay connected with friends

  19. Cold electrical connection for FAIR/ SIS100

    CERN Document Server

    Kauschke, M; Quack, H

    2009-01-01

    The Facility of Antiproton and Ion Research (FAIR) will be an international centre for atomic-, plasma- and nuclear- physics, located next to Gesellschaft für Schwerionenforschung (GSI), Darmstadt. FAIR will be composed from two synchrotrons and four storage rings. Both synchrotrons, SIS100 and SIS300, are designed with superconducting magnets. For radiation protection reasons and landscaping restrictions the synchrotrons will be placed underground, whereas the power supplies will be placed within three service buildings above ground level. To save space and refrigeration power a superconducting electrical connection will be implemented. The mechanical and thermal design of this connection will be presented in the paper.

  20. A Grid-Connected Desalination Plant Operation

    Directory of Open Access Journals (Sweden)

    Won Ko

    2013-02-01

    Full Text Available In this paper, a grid-connected desalination plant operation approach is suggested. In desalination plant, large amount of energy is needed to operate pump and motor; hence most of energy is electricity. For this reason, the largest part of the operation cost is electricity charges. To demonstrate power usage, small size desalination measuring system mounted plant is used. Finally, to show the result of a grid-connected desalination plant operation, electric tariff rate of Korea is used. The result shows that total cost reduction rate is calculated about 1.6% of annual total electric plant operation cost.

  1. The canonical connection in quantum mechanics

    CERN Document Server

    Lévai, Peter; Tsutsui, I; Levay, Peter; McMullan, David; Tsutsui, Izumi

    1995-01-01

    In this paper we investigate the form of induced gauge fields that arises in two types of quantum systems. In the first we consider quantum mechanics on coset spaces G/H, and argue that G-invariance is central to the emergence of the H-connection as induced gauge fields in the different quantum sectors. We then demonstrate why the same connection, now giving rise to the non-abelian generalization of Berry's phase, can also be found in systems which have slow variables taking values in such a coset space.

  2. The canonical connection in quantum mechanics

    Energy Technology Data Exchange (ETDEWEB)

    Levay, P. [Budapesti Mueszaki Egyetem, Budapest (Hungary); Mcmullan, D.; Tsutsui, Izumi

    1995-04-01

    In this paper we investigate the form of induced gauge fields that arises in two types of quantum systems. In the first we consider quantum mechanics on coset spaces G/H, and argue that G-invariance is central to the emergence of the H-connection as induced gauge fields in the different quantum sectors. We then demonstrate why the same connection, now giving rise to the non-abelian generalization of Berry`s phase, can also be found in systems which have slow variables taking values in such a coset space. (author).

  3. Electromagnetism from extra space multi connectivity

    Energy Technology Data Exchange (ETDEWEB)

    Gauthier, C. [Moncton Univ., Moncton (France). Dept. de Mathematiques et de Statistique

    2001-09-01

    In a unified field theory of the Kaluza-Klein type, it is used a multi connected extra space to interpret geometrically the quantum properties of physics. This paper presents a pure geometric interpretation of electromagnetism. The electric change of a body is identified with its cross-section for interaction of twisted waves due to the extra space multi connectivity. A by-product of this interpretation is an expression for the permittivity of free space as an integral of the flux of these waves over their frequencies.

  4. Supervised hub-detection for brain connectivity

    DEFF Research Database (Denmark)

    Kasenburg, Niklas; Liptrot, Matthew George; Reislev, Nina Linde

    2016-01-01

    A structural brain network consists of physical connections between brain regions. Brain network analysis aims to find features associated with a parameter of interest through supervised prediction models such as regression. Unsupervised preprocessing steps like clustering are often applied......-detection and a linear regression using the original network connections as features. The results show that the SHD is able to retain regression performance, while still finding hubs that represent the underlying variation in the population. Although here we applied the SHD to brain networks, it can be applied to any...

  5. Connecting to Our Community: Utilizing Photovoice as a Pedagogical Tool to Connect College Students to Science

    Science.gov (United States)

    Cook, Kristin; Quigley, Cassie

    2013-01-01

    In this study, we investigated the ways in which university students connected with science through the use of photovoice (Wang & Burris, 1994) as a pedagogical tool. Results indicated that students came to appreciate their connections to the science that operates in their lives as they reflected on and became empowered with regard to the science…

  6. DiseaseConnect: a comprehensive web server for mechanism-based disease-disease connections.

    Science.gov (United States)

    Liu, Chun-Chi; Tseng, Yu-Ting; Li, Wenyuan; Wu, Chia-Yu; Mayzus, Ilya; Rzhetsky, Andrey; Sun, Fengzhu; Waterman, Michael; Chen, Jeremy J W; Chaudhary, Preet M; Loscalzo, Joseph; Crandall, Edward; Zhou, Xianghong Jasmine

    2014-07-01

    The DiseaseConnect (http://disease-connect.org) is a web server for analysis and visualization of a comprehensive knowledge on mechanism-based disease connectivity. The traditional disease classification system groups diseases with similar clinical symptoms and phenotypic traits. Thus, diseases with entirely different pathologies could be grouped together, leading to a similar treatment design. Such problems could be avoided if diseases were classified based on their molecular mechanisms. Connecting diseases with similar pathological mechanisms could inspire novel strategies on the effective repositioning of existing drugs and therapies. Although there have been several studies attempting to generate disease connectivity networks, they have not yet utilized the enormous and rapidly growing public repositories of disease-related omics data and literature, two primary resources capable of providing insights into disease connections at an unprecedented level of detail. Our DiseaseConnect, the first public web server, integrates comprehensive omics and literature data, including a large amount of gene expression data, Genome-Wide Association Studies catalog, and text-mined knowledge, to discover disease-disease connectivity via common molecular mechanisms. Moreover, the clinical comorbidity data and a comprehensive compilation of known drug-disease relationships are additionally utilized for advancing the understanding of the disease landscape and for facilitating the mechanism-based development of new drug treatments.

  7. DiseaseConnect: a comprehensive web server for mechanism-based disease–disease connections

    Science.gov (United States)

    Liu, Chun-Chi; Tseng, Yu-Ting; Li, Wenyuan; Wu, Chia-Yu; Mayzus, Ilya; Rzhetsky, Andrey; Sun, Fengzhu; Waterman, Michael; Chen, Jeremy J. W.; Chaudhary, Preet M.; Loscalzo, Joseph; Crandall, Edward; Zhou, Xianghong Jasmine

    2014-01-01

    The DiseaseConnect (http://disease-connect.org) is a web server for analysis and visualization of a comprehensive knowledge on mechanism-based disease connectivity. The traditional disease classification system groups diseases with similar clinical symptoms and phenotypic traits. Thus, diseases with entirely different pathologies could be grouped together, leading to a similar treatment design. Such problems could be avoided if diseases were classified based on their molecular mechanisms. Connecting diseases with similar pathological mechanisms could inspire novel strategies on the effective repositioning of existing drugs and therapies. Although there have been several studies attempting to generate disease connectivity networks, they have not yet utilized the enormous and rapidly growing public repositories of disease-related omics data and literature, two primary resources capable of providing insights into disease connections at an unprecedented level of detail. Our DiseaseConnect, the first public web server, integrates comprehensive omics and literature data, including a large amount of gene expression data, Genome-Wide Association Studies catalog, and text-mined knowledge, to discover disease–disease connectivity via common molecular mechanisms. Moreover, the clinical comorbidity data and a comprehensive compilation of known drug–disease relationships are additionally utilized for advancing the understanding of the disease landscape and for facilitating the mechanism-based development of new drug treatments. PMID:24895436

  8. Graphene nanodevices for DNA sequencing

    Science.gov (United States)

    Heerema, Stephanie J.; Dekker, Cees

    2016-02-01

    Fast, cheap, and reliable DNA sequencing could be one of the most disruptive innovations of this decade, as it will pave the way for personalized medicine. In pursuit of such technology, a variety of nanotechnology-based approaches have been explored and established, including sequencing with nanopores. Owing to its unique structure and properties, graphene provides interesting opportunities for the development of a new sequencing technology. In recent years, a wide range of creative ideas for graphene sequencers have been theoretically proposed and the first experimental demonstrations have begun to appear. Here, we review the different approaches to using graphene nanodevices for DNA sequencing, which involve DNA passing through graphene nanopores, nanogaps, and nanoribbons, and the physisorption of DNA on graphene nanostructures. We discuss the advantages and problems of each of these key techniques, and provide a perspective on the use of graphene in future DNA sequencing technology.

  9. Solid phase sequencing of biopolymers

    Science.gov (United States)

    Cantor, Charles R.; Hubert, Koster

    2014-06-24

    This invention relates to methods for detecting and sequencing target nucleic acid sequences, to mass modified nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involve hybridizing the nucleic acids or nucleic acids which represent complementary or homologous sequences of the target to an array of nucleic acid probes. These probes comprise a single-stranded portion, an optional double-stranded portion and a variable sequence within the single-stranded portion. The molecular weights of the hybridized nucleic acids of the set can be determined by mass spectroscopy, and the sequence of the target determined from the molecular weights of the fragments. Probes may be affixed to a solid support such as a hybridization chip to facilitate automated molecular weight analysis and identification of the target sequence.

  10. Short sequence motifs, overrepresented in mammalian conservednon-coding sequences

    Energy Technology Data Exchange (ETDEWEB)

    Minovitsky, Simon; Stegmaier, Philip; Kel, Alexander; Kondrashov,Alexey S.; Dubchak, Inna

    2007-02-21

    Background: A substantial fraction of non-coding DNAsequences of multicellular eukaryotes is under selective constraint. Inparticular, ~;5 percent of the human genome consists of conservednon-coding sequences (CNSs). CNSs differ from other genomic sequences intheir nucleotide composition and must play important functional roles,which mostly remain obscure.Results: We investigated relative abundancesof short sequence motifs in all human CNSs present in the human/mousewhole-genome alignments vs. three background sets of sequences: (i)weakly conserved or unconserved non-coding sequences (non-CNSs); (ii)near-promoter sequences (located between nucleotides -500 and -1500,relative to a start of transcription); and (iii) random sequences withthe same nucleotide composition as that of CNSs. When compared tonon-CNSs and near-promoter sequences, CNSs possess an excess of AT-richmotifs, often containing runs of identical nucleotides. In contrast, whencompared to random sequences, CNSs contain an excess of GC-rich motifswhich, however, lack CpG dinucleotides. Thus, abundance of short sequencemotifs in human CNSs, taken as a whole, is mostly determined by theiroverall compositional properties and not by overrepresentation of anyspecific short motifs. These properties are: (i) high AT-content of CNSs,(ii) a tendency, probably due to context-dependent mutation, of A's andT's to clump, (iii) presence of short GC-rich regions, and (iv) avoidanceof CpG contexts, due to their hypermutability. Only a small number ofshort motifs, overrepresented in all human CNSs are similar to bindingsites of transcription factors from the FOX family.Conclusion: Human CNSsas a whole appear to be too broad a class of sequences to possess strongfootprints of any short sequence-specific functions. Such footprintsshould be studied at the level of functional subclasses of CNSs, such asthose which flank genes with a particular pattern of expression. Overallproperties of CNSs are affected by

  11. The relationship of anatomical and functional connectivity to resting-state connectivity in primate somatosensory cortex.

    Science.gov (United States)

    Wang, Zheng; Chen, Li Min; Négyessy, László; Friedman, Robert M; Mishra, Arabinda; Gore, John C; Roe, Anna W

    2013-06-19

    Studies of resting-state activity in the brain have provoked critical questions about the brain's functional organization, but the biological basis of this activity is not clear. Specifically, the relationships between interregional correlations in resting-state measures of activity, neuronal functional connectivity and anatomical connectivity are much debated. To investigate these relationships, we have examined both anatomical and steady-state functional connectivity within the hand representation of primary somatosensory cortex (areas 3b and 1) in anesthetized squirrel monkeys. The comparison of three data sets (fMRI, electrophysiological, and anatomical) indicate two primary axes of information flow within the SI: prominent interdigit interactions within area 3b and predominantly homotopic interactions between area 3b and area 1. These data support a strikingly close relationship between baseline functional connectivity and anatomical connections. This study extends findings derived from large-scale cortical networks to the realm of local millimeter-scale networks.

  12. Biosensors for DNA sequence detection

    Science.gov (United States)

    Vercoutere, Wenonah; Akeson, Mark

    2002-01-01

    DNA biosensors are being developed as alternatives to conventional DNA microarrays. These devices couple signal transduction directly to sequence recognition. Some of the most sensitive and functional technologies use fibre optics or electrochemical sensors in combination with DNA hybridization. In a shift from sequence recognition by hybridization, two emerging single-molecule techniques read sequence composition using zero-mode waveguides or electrical impedance in nanoscale pores.

  13. Nonlinear analysis of biological sequences

    Energy Technology Data Exchange (ETDEWEB)

    Torney, D.C.; Bruno, W.; Detours, V. [and others

    1998-11-01

    This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The main objectives of this project involved deriving new capabilities for analyzing biological sequences. The authors focused on tabulating the statistical properties exhibited by Human coding DNA sequences and on techniques of inferring the phylogenetic relationships among protein sequences related by descent.

  14. Coupled Intrinsic Connectivity Distribution analysis: a method for exploratory connectivity analysis of paired FMRI data.

    Directory of Open Access Journals (Sweden)

    Dustin Scheinost

    Full Text Available We present a novel voxel-based connectivity approach for paired functional magnetic resonance imaging (fMRI data collected under two different conditions labeled the Coupled Intrinsic Connectivity Distribution (coupled-ICD. Our proposed method jointly models both conditions to incorporate additional paired information into the connectivity metric. Voxel-based connectivity holds promise as a clinical tool to characterize a wide range of neurological and psychiatric diseases, and monitor their treatment. As such, examining paired connectivity data such as scans acquired pre- and post-intervention is an important application for connectivity methodologically. When presented with data from paired conditions, conventional voxel-based methods analyze each condition separately. However, summarizing each connection separately can misrepresent patterns of changes in connectivity. We show that commonly used methods can underestimate functional changes and subsequently introduce and evaluate our solution to this problem, the coupled-ICD metric, using two studies: 1 healthy controls scanned awake and under anesthesia, and 2 cocaine-dependent subjects and healthy controls scanned while being presented with relaxing or drug-related imagery cues. The coupled-ICD approach detected differences between paired conditions in similar brain regions as the conventional approaches while also revealing additional changes in regions not identified using conventional voxel-based connectivity analyses. Follow-up seed-based analyses on data independent from the voxel-based results also showed connectivity differences between conditions in regions detected by coupled-ICD. This approach of jointly analyzing paired resting-state scans provides a new and important tool with many applications for clinical and basic neuroscience research.

  15. ABS: Sequence alignment by scanning

    KAUST Repository

    Bonny, Mohamed Talal

    2011-08-01

    Sequence alignment is an essential tool in almost any computational biology research. It processes large database sequences and considered to be high consumers of computation time. Heuristic algorithms are used to get approximate but fast results. We introduce fast alignment algorithm, called Alignment By Scanning (ABS), to provide an approximate alignment of two DNA sequences. We compare our algorithm with the well-known alignment algorithms, the FASTA (which is heuristic) and the \\'Needleman-Wunsch\\' (which is optimal). The proposed algorithm achieves up to 76% enhancement in alignment score when it is compared with the FASTA Algorithm. The evaluations are conducted using different lengths of DNA sequences. © 2011 IEEE.

  16. Fast global sequence alignment technique

    KAUST Repository

    Bonny, Mohamed Talal

    2011-11-01

    Bioinformatics database is growing exponentially in size. Processing these large amount of data may take hours of time even if super computers are used. One of the most important processing tool in Bioinformatics is sequence alignment. We introduce fast alignment algorithm, called \\'Alignment By Scanning\\' (ABS), to provide an approximate alignment of two DNA sequences. We compare our algorithm with the wellknown sequence alignment algorithms, the \\'GAP\\' (which is heuristic) and the \\'Needleman-Wunsch\\' (which is optimal). The proposed algorithm achieves up to 51% enhancement in alignment score when it is compared with the GAP Algorithm. The evaluations are conducted using different lengths of DNA sequences. © 2011 IEEE.

  17. Assembly sequencing with toleranced parts

    Energy Technology Data Exchange (ETDEWEB)

    Latombe, J.C. [Stanford Univ., CA (United States). Robotics Lab.; Wilson, R.H. [Sandia National Labs., Albuquerque, NM (United States). Intelligent Systems and Robotics Center

    1995-02-21

    The goal of assembly sequencing is to plan a feasible series of operations to construct a product from its individual parts. Previous research has thoroughly investigated assembly sequencing under the assumption that parts have nominal geometry. This paper considers the case where parts have toleranced geometry. Its main contribution is an efficient procedure that decides if a product admits an assembly sequence with infinite translations that is feasible for all possible instances of the components within the specified tolerances. If the product admits one such sequence, the procedure can also generate it. For the cases where there exists no such assembly sequence, another procedure is proposed which generates assembly sequences that are feasible only for some values of the toleranced dimensions. If this procedure produces no such sequence, then no instance of the product is assemblable. Finally, this paper analyzes the relation between assembly and disassembly sequences in the presence of toleranced parts. This work assumes a simple, but non-trivial tolerance language that falls short of capturing all imperfections of a manufacturing process. Hence, it is only one step toward assembly sequencing with toleranced parts.

  18. SNMR pulse sequence phase cycling

    Science.gov (United States)

    Walsh, David O; Grunewald, Elliot D

    2013-11-12

    Technologies applicable to SNMR pulse sequence phase cycling are disclosed, including SNMR acquisition apparatus and methods, SNMR processing apparatus and methods, and combinations thereof. SNMR acquisition may include transmitting two or more SNMR pulse sequences and applying a phase shift to a pulse in at least one of the pulse sequences, according to any of a variety cycling techniques. SNMR processing may include combining SNMR from a plurality of pulse sequences comprising pulses of different phases, so that desired signals are preserved and indesired signals are canceled.

  19. Blazar Sequence in Fermi Era

    Indian Academy of Sciences (India)

    Liang Chen

    2014-09-01

    In this paper, we review the latest research results on the topic of blazar sequence. It seems that the blazar sequence is phenomenally ruled out, while the theoretical blazar sequence still holds. We point out that black hole mass is a dominated parameter accounting for high-power-high-synchrotron-peaked and low-power-low-sychrotron-peaked blazars. Because most blazars have similar size of emission region, theoretical blazar sequence implies that the break of Spectral Energy Distribution (SED) is a cooling break in nature.

  20. Cerebro-cerebellar connectivity is increased in primary lateral sclerosis

    Directory of Open Access Journals (Sweden)

    Avner Meoded

    2015-01-01

    Full Text Available Increased functional connectivity in resting state networks was found in several studies of patients with motor neuron disorders, although diffusion tensor imaging studies consistently show loss of white matter integrity. To understand the relationship between structural connectivity and functional connectivity, we examined the structural connections between regions with altered functional connectivity in patients with primary lateral sclerosis (PLS, a long-lived motor neuron disease. Connectivity matrices were constructed from resting state fMRI in 16 PLS patients to identify areas of differing connectivity between patients and healthy controls. Probabilistic fiber tracking was used to examine structural connections between regions of differing connectivity. PLS patients had 12 regions with increased functional connectivity compared to controls, with a predominance of cerebro-cerebellar connections. Increased functional connectivity was strongest between the cerebellum and cortical motor areas and between the cerebellum and frontal and temporal cortex. Fiber tracking detected no difference in connections between regions with increased functional connectivity. We conclude that functional connectivity changes are not strongly based in structural connectivity. Increased functional connectivity may be caused by common inputs, or by reduced selectivity of cortical activation, which could result from loss of intracortical inhibition when cortical afferents are intact.

  1. Cerebro-cerebellar connectivity is increased in primary lateral sclerosis.

    Science.gov (United States)

    Meoded, Avner; Morrissette, Arthur E; Katipally, Rohan; Schanz, Olivia; Gotts, Stephen J; Floeter, Mary Kay

    2015-01-01

    Increased functional connectivity in resting state networks was found in several studies of patients with motor neuron disorders, although diffusion tensor imaging studies consistently show loss of white matter integrity. To understand the relationship between structural connectivity and functional connectivity, we examined the structural connections between regions with altered functional connectivity in patients with primary lateral sclerosis (PLS), a long-lived motor neuron disease. Connectivity matrices were constructed from resting state fMRI in 16 PLS patients to identify areas of differing connectivity between patients and healthy controls. Probabilistic fiber tracking was used to examine structural connections between regions of differing connectivity. PLS patients had 12 regions with increased functional connectivity compared to controls, with a predominance of cerebro-cerebellar connections. Increased functional connectivity was strongest between the cerebellum and cortical motor areas and between the cerebellum and frontal and temporal cortex. Fiber tracking detected no difference in connections between regions with increased functional connectivity. We conclude that functional connectivity changes are not strongly based in structural connectivity. Increased functional connectivity may be caused by common inputs, or by reduced selectivity of cortical activation, which could result from loss of intracortical inhibition when cortical afferents are intact.

  2. Sequence Algebra, Sequence Decision Diagrams and Dynamic Fault Trees

    Energy Technology Data Exchange (ETDEWEB)

    Rauzy, Antoine B., E-mail: Antoine.Rauzy@lix.polytechnique.f [LIX-CNRS, Computer Science, Ecole Polytechnique, 91128 Palaiseau Cedex (France)

    2011-07-15

    A large attention has been focused on the Dynamic Fault Trees in the past few years. By adding new gates to static (regular) Fault Trees, Dynamic Fault Trees aim to take into account dependencies among events. Merle et al. proposed recently an algebraic framework to give a formal interpretation to these gates. In this article, we extend Merle et al.'s work by adopting a slightly different perspective. We introduce Sequence Algebras that can be seen as Algebras of Basic Events, representing failures of non-repairable components. We show how to interpret Dynamic Fault Trees within this framework. Finally, we propose a new data structure to encode sets of sequences of Basic Events: Sequence Decision Diagrams. Sequence Decision Diagrams are very much inspired from Minato's Zero-Suppressed Binary Decision Diagrams. We show that all operations of Sequence Algebras can be performed on this data structure.

  3. Values Connecting Societies and Water Systems

    NARCIS (Netherlands)

    J.A. van Ast (Jacko); J.J. Bouma (Jan Jaap); M. Bal (Mansee)

    2013-01-01

    markdownabstract__Introduction__ Water systems such as rivers and lakes have many important values for ecosystems and human societies. Both economical, social-ecological, cultural and political values are met by the water systems, connecting different activities in human society and ecosystem

  4. [Pulmonary involvement in connective tissue disease].

    Science.gov (United States)

    Bartosiewicz, Małgorzata

    2016-01-01

    The connective tissue diseases are a variable group of autoimmune mediated disorders characterized by multiorgan damage. Pulmonary complications are common, usually occur after the onset of joint symptoms, but can also be initially presenting complaint. The respiratory system may be involved in all its component: airways, vessels, parenchyma, pleura and respiratory muscles. Lung involvement is an increasing cause of morbidity and mortality in the connective tissue diseases. Clinical course is highly variable - can range from mild to rapidly progressive, some processes are reversible, while others are irreversible. Thus, the identification of reversible disease , and separately progressive disease, are important clinical issues. The frequency, clinical presentation, prognosis and responce to therapy are different, depending on the pattern of involvement as well as on specyfic diagnostic method used to identify it. High- resolution computed tompography plays an important role in identifying patients with respiratory involvement. Pulmonary function tests are a sensitive tool detecting interstitial lung disease. In this article, pulmonary lung involvement accompanying most frequently apperaing connective tissue diseases - rheumatoid arthritis, systemic sclerosis, lupus erythematosus, polymyositis/dermatomyositis, Sjögrens syndrome and mixed connective tissue disaese are reviewed.

  5. Connections, Coherence, and Cognition in Composition.

    Science.gov (United States)

    Goldstein, Elizabeth; Perfetti, Charles

    In a study conducted to show the importance of sentence connections as a way of looking at a writer's cognitive processes, three devices used to achieve coherence in written discourse were compared and proved to be unequally effective. The devices were cohesion (use of a textual reference in a sentence that has an antecedent in a preceding…

  6. "Scars" connect classical and quantum theory

    CERN Multimedia

    Monteiro, T

    1990-01-01

    Chaotic systems are unstable and extremely sensitive to initial condititions. So far, scientists have been unable to demonstrate that the same kind of behaviour exists in quantum or microscopic systems. New connections have been discovered though between classical and quantum theory. One is the phenomena of 'scars' which cut through the wave function of a particle (1 page).

  7. Precentral gyrus functional connectivity signatures of autism

    Directory of Open Access Journals (Sweden)

    Mary Beth eNebel

    2014-05-01

    Full Text Available Motor impairments are prevalent in children with autism spectrum disorders (ASD and are perhaps the earliest symptoms to develop. In addition, motor skills relate to the communicative/social deficits at the core of ASD diagnosis, and these behavioral deficits may reflect abnormal connectivity within brain networks underlying motor control and learning. Despite the fact that motor abnormalities in ASD are well-characterized, there remains a fundamental disconnect between the complexity of the clinical presentation of ASD and the underlying neurobiological mechanisms. In this study, we examined connectivity within and between functional subregions of a key component of the motor control network, the precentral gyrus, using resting state functional Magnetic Resonance Imaging data collected from a large, heterogeneous sample of individuals with ASD as well as neurotypical controls. We found that the strength of connectivity within and between distinct functional subregions of the precentral gyrus was related to ASD diagnosis and to the severity of ASD traits. In particular, connectivity involving the dorsomedial (lower limb/trunk subregion was abnormal in ASD individuals as predicted by models using a dichotomous variable coding for the presence of ASD, as well as models using symptom severity ratings. These findings provide further support for a link between motor and social/communicative abilities in ASD.

  8. Making Connections: Explorations in Creative Expression.

    Science.gov (United States)

    Hahn, Sidney L.

    A series of strategies called the "Synectics Model," can be used by teachers in helping students to break away from usual thought patterns and to make new connections. Its purpose is to increase creativity and to produce lateral thinking. The activities employed involve the use of metaphor. Examples of the model are provided that were…

  9. Parity and the spin{statistics connection

    Indian Academy of Sciences (India)

    J A Morgan

    2005-09-01

    A simple demonstration of the spin-statistics connection for general causal fields is obtained by using the parity operation to exchange spatial coordinates in the scalar product of a locally commuting field operator, evaluated at position x, with the same field operator evaluated at -x, at equal times.

  10. Assessing the Security of Connected Diabetes Devices.

    Science.gov (United States)

    Out, Dirk-Jan; Tettero, Olaf

    2017-03-01

    This article discusses the assessment of the (cyber)security of wirelessly connected diabetes devices under the DTSEC standard. We discuss the relation between diabetes devices and hackers, provide an overview of the DTSEC standard, and describe the process of security assessment of diabetes devices.

  11. Surprising Connections between Partitions and Divisors

    Science.gov (United States)

    Osler, Thomas J.; Hassen, Abdulkadir; Chandrupatla, Tirupathi R.

    2007-01-01

    The sum of the divisors of a positive integer is one of the most interesting concepts in multiplicative number theory, while the number of ways of expressing a number as a sum is a primary topic in additive number theory. In this article, we describe some of the surprising connections between and similarities of these two concepts.

  12. 14 CFR 33.29 - Instrument connection.

    Science.gov (United States)

    2010-01-01

    ... connection must be provided on each turbojet engine for an indicator system to indicate rotor system... necessary to ensure that the probability of a fault propagating from instrumentation and monitoring functions to control functions, or vice versa, is consistent with the failure effect of the fault. (h)...

  13. Supervised hub-detection for brain connectivity

    Science.gov (United States)

    Kasenburg, Niklas; Liptrot, Matthew; Reislev, Nina Linde; Garde, Ellen; Nielsen, Mads; Feragen, Aasa

    2016-03-01

    A structural brain network consists of physical connections between brain regions. Brain network analysis aims to find features associated with a parameter of interest through supervised prediction models such as regression. Unsupervised preprocessing steps like clustering are often applied, but can smooth discriminative signals in the population, degrading predictive performance. We present a novel hub-detection optimized for supervised learning that both clusters network nodes based on population level variation in connectivity and also takes the learning problem into account. The found hubs are a low-dimensional representation of the network and are chosen based on predictive performance as features for a linear regression. We apply our method to the problem of finding age-related changes in structural connectivity. We compare our supervised hub-detection (SHD) to an unsupervised hub-detection and a linear regression using the original network connections as features. The results show that the SHD is able to retain regression performance, while still finding hubs that represent the underlying variation in the population. Although here we applied the SHD to brain networks, it can be applied to any network regression problem. Further development of the presented algorithm will be the extension to other predictive models such as classification or non-linear regression.

  14. Connection Making between the Sister Arts.

    Science.gov (United States)

    Golden, Catherine

    A literature course entitled "The Victorian Illustrated Book: A Marriage of Image and Word," offered at Skidmore College in New York, was designed to help students make connections between art and literature. Based on the premise that illustrations in Victorian books can be "decoded" much like a written text, students were…

  15. Connecting and Communicating with Students on Facebook

    Science.gov (United States)

    Miller, Sarah Elizabeth; Jensen, Lauren A.

    2007-01-01

    Facebook is a social network that connects people with other people. Librarians have created Facebook Groups to share ideas and to debate how to use this resource as a potential marketing and/or reference tool. Based on conversations among these librarians, it appears that student response to library outreach on this medium is lackluster at best,…

  16. GOOSE: Semantic search on Internet connected sensors

    NARCIS (Netherlands)

    Schutte, K.; Bomhof, F.W.; Burghouts, G.J.; Diggelen, J. van; Hiemstra, P.; Hof, J. van 't; Kraaij, W.; Pasman, K.H.W.; Smith, A.J.E.; Versloot, C.A.; Wit, J.J. de

    2013-01-01

    More and more sensors are getting Internet connected. Examples are cameras on cell phones, CCTV cameras for traffic control as well as dedicated security and defense sensor systems. Due to the steadily increasing data volume, human exploitation of all this sensor data is impossible for effective mis

  17. Literacy and Sexuality: What's the Connection?

    Science.gov (United States)

    Ashcraft, Catherine

    2009-01-01

    In this column, the author highlights how the current framing of teen sexuality obscures important connections between literacy and sexuality. She argues that we need to challenge two current assumptions: the assumption that teen sexuality is primarily about public health and the assumption that all efforts to address teen sexuality are…

  18. Connecting Reading and Writing: A Case Study

    Science.gov (United States)

    Li, Zhanfang

    2015-01-01

    Connecting reading and writing, proposed by many scholars, is realized in this case study. The 30 participants in this study are the English majors of the third year in one School of Foreign Languages in Beijing. They are encouraged to write journals every week, based on the source text materials in their Intensive Reading class, with the final…

  19. Mathematics and Molecules: Exploring Connections via Programming.

    Science.gov (United States)

    Ploger, Don; Carlock, Margaret

    1996-01-01

    Examines the self-directed activity of two students who learned about molecular structure by writing computer programs. The programs displayed the solution of a mathematics problem, then the programs were extended to represent several classes of organic molecules. Different ways to enhance mathematical connections to chemistry education are…

  20. Algebraic connection theory of L-modules

    NARCIS (Netherlands)

    Ruiter, Jan de

    1972-01-01

    It is striking that many contravariant algebraic aspects of manifolds and especially of connections and cunvature are not restricted to manifolds. Another question raised by the theory is the following one: how far are diffenentiable functions and differentiable fields on a differentiable manifold d

  1. Quantized Abelian principle connections on Lorentzian manifolds

    Energy Technology Data Exchange (ETDEWEB)

    Benini, Marco [Pavia Univ. (Italy); Istituto Nazionale di Fisica Nucleare, Pavia (Italy); Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik; Dappiaggi, Claudio [Pavia Univ. (Italy); Istituto Nazionale di Fisica Nucleare, Pavia (Italy); Schenkel, Alexander [Bergische Univ., Wuppertal (Germany). Fachgruppe Mathematik

    2013-03-15

    We construct a covariant functor from a category of Abelian principal bundles over globally hyperbolic spacetimes to a category of *-algebras that describes quantized principal connections. We work within an appropriate differential geometric setting by using the bundle of connections and we study the full gauge group, namely the group of vertical principal bundle automorphisms. Properties of our functor are investigated in detail and, similar to earlier works, it is found that due to topological obstructions the locality property of locally covariant quantum field theory is violated. Furthermore, we prove that, for Abelian structure groups containing a nontrivial compact factor, the gauge invariant Borchers- Uhlmann algebra of the vector dual of the bundle of connections is not separating on gauge equivalence classes of principal connections. We introduce a topological generalization of the concept of locally covariant quantum fields. As examples, we construct for the full subcategory of principal U(1)-bundles two natural transformations from singular homology functors to the quantum field theory functor that can be interpreted as the Euler class and the electric charge. In this case we also prove that the electric charges can be consistently set to zero, which yields another quantum field theory functor that satisfies all axioms of locally covariant quantum field theory.

  2. Structural connectivity asymmetry in the neonatal brain.

    Science.gov (United States)

    Ratnarajah, Nagulan; Rifkin-Graboi, Anne; Fortier, Marielle V; Chong, Yap Seng; Kwek, Kenneth; Saw, Seang-Mei; Godfrey, Keith M; Gluckman, Peter D; Meaney, Michael J; Qiu, Anqi

    2013-07-15

    Asymmetry of the neonatal brain is not yet understood at the level of structural connectivity. We utilized DTI deterministic tractography and structural network analysis based on graph theory to determine the pattern of structural connectivity asymmetry in 124 normal neonates. We tracted white matter axonal pathways characterizing interregional connections among brain regions and inferred asymmetry in left and right anatomical network properties. Our findings revealed that in neonates, small-world characteristics were exhibited, but did not differ between the two hemispheres, suggesting that neighboring brain regions connect tightly with each other, and that one region is only a few paths away from any other region within each hemisphere. Moreover, the neonatal brain showed greater structural efficiency in the left hemisphere than that in the right. In neonates, brain regions involved in motor, language, and memory functions play crucial roles in efficient communication in the left hemisphere, while brain regions involved in emotional processes play crucial roles in efficient communication in the right hemisphere. These findings suggest that even at birth, the topology of each cerebral hemisphere is organized in an efficient and compact manner that maps onto asymmetric functional specializations seen in adults, implying lateralized brain functions in infancy.

  3. Emotional Connections in Higher Education Marketing

    Science.gov (United States)

    Durkin, Mark; McKenna, Seamas; Cummins, Darryl

    2012-01-01

    Purpose: Through examination of a case study this paper aims to describe a brand re-positioning exercise and explore how an emotionally driven approach to branding can help create meaningful connections with potential undergraduate students and can positively influence choice. Design/methodology/approach: The paper's approach is a case study…

  4. 24 CFR 3285.606 - Ductwork connections.

    Science.gov (United States)

    2010-04-01

    ... to UL 181A (incorporated by reference, see § 3285.4), for closure systems with rigid air ducts and connectors, or UL 181B (incorporated by reference, see § 3285.4), for closure systems with flexible air ducts... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Ductwork connections....

  5. Connections between the matching and chromatic polynomials

    Directory of Open Access Journals (Sweden)

    E. J. Farrell

    1992-01-01

    Full Text Available The main results established are (i a connection between the matching and chromatic polynomials and (ii a formula for the matching polynomial of a general complement of a subgraph of a graph. Some deductions on matching and chromatic equivalence and uniqueness are made.

  6. An Interoperable Security Framework for Connected Healthcare

    NARCIS (Netherlands)

    Asim, M.; Petkovic, M.; Qu, M.; Wang, C.

    2011-01-01

    Connected and interoperable healthcare system promises to reduce thecost of the healthcare delivery, increase its efficiency and enableconsumers to better engage with clinicians and manage their care. However at the same time it introduces new risks towards security andprivacy of personal health inf

  7. Learning and the Teacher-Student Connection

    Science.gov (United States)

    Protheroe, Nancy

    2005-01-01

    A critical element in effective teaching is establishing positive connections with students, particularly those at risk of failure. This article presents the findings and suggestions of researchers who have examined the practices and impact of caring teachers, and how their students perceive them.

  8. A Scheme for Connecting Quantum Components

    Institute of Scientific and Technical Information of China (English)

    TAN Xiao-Hui; FANG Xi-Ming; WANG Guo-You

    2006-01-01

    @@ We propose an approach to connect components of a quantum computer by using a linear cluster state, with which an arbitrary N-particle state can be perfectly propagated between quantum components in two ways that are based on feedback measurements and local transformation.

  9. Connected Speech Processes in Australian English.

    Science.gov (United States)

    Ingram, J. C. L.

    1989-01-01

    Explores the role of Connected Speech Processes (CSP) in accounting for sociolinguistically significant dimensions of speech variation, and presents initial findings on the distribution of CSPs in the speech of Australian adolescents. The data were gathered as part of a wider survey of speech of Brisbane school children. (Contains 26 references.)…

  10. Single Word versus Connected Speech Articulation Testing.

    Science.gov (United States)

    Johnson, John P.; And Others

    1980-01-01

    The study compared the productions of 35 articulation impaired children (ages 3 to 10) obtained by picture elicited single word and connected speech sampling methods. Productions were compared on the basis of both the number and type of errors made under the two testing conditions. (Author/PHR)

  11. Climate change and coral reef connectivity

    Science.gov (United States)

    Munday, P. L.; Leis, J. M.; Lough, J. M.; Paris, C. B.; Kingsford, M. J.; Berumen, M. L.; Lambrechts, J.

    2009-06-01

    This review assesses and predicts the impacts that rapid climate change will have on population connectivity in coral reef ecosystems, using fishes as a model group. Increased ocean temperatures are expected to accelerate larval development, potentially leading to reduced pelagic durations and earlier reef-seeking behaviour. Depending on the spatial arrangement of reefs, the expectation would be a reduction in dispersal distances and the spatial scale of connectivity. Small increase in temperature might enhance the number of larvae surviving the pelagic phase, but larger increases are likely to reduce reproductive output and increase larval mortality. Changes to ocean currents could alter the dynamics of larval supply and changes to planktonic productivity could affect how many larvae survive the pelagic stage and their condition at settlement; however, these patterns are likely to vary greatly from place-to-place and projections of how oceanographic features will change in the future lack sufficient certainty and resolution to make robust predictions. Connectivity could also be compromised by the increased fragmentation of reef habitat due to the effects of coral bleaching and ocean acidification. Changes to the spatial and temporal scales of connectivity have implications for the management of coral reef ecosystems, especially the design and placement of marine-protected areas. The size and spacing of protected areas may need to be strategically adjusted if reserve networks are to retain their efficacy in the future.

  12. Exploring Poetry: The Reading and Writing Connection.

    Science.gov (United States)

    Ediger, Marlow

    Connecting reading and writing has become an important trend in teaching the language arts. Poetry, as a salient facet of the reading curriculum, integrates well with different purposes in writing. Poetry read aloud to students can assist learners to enjoy reading activities and develop the feeling and aesthetic dimension of learning, among other…

  13. Working Connections: Class of 2002. Project Brief.

    Science.gov (United States)

    Becker, Kristin; Barnett, Lynn

    Working Connections is a program resulting from a partnership between the American Association of Community Colleges (AACC) and the Microsoft Corporation. The program was designed to help increase the number of skilled information technology (IT) workers by providing focused training in IT careers. Since 1998, AACC and Microsoft have awarded cash…

  14. Transformerless Photovoltaic Inverters Connected to the Grid

    DEFF Research Database (Denmark)

    Kerekes, Tamas; Teodorescu, Remus; Borup, Uffe

    2007-01-01

    -phase with respect to the leakage current generation. The best results, both for single-phase and three-phase systems, are obtained when the middle point of the input capacitors is connected to the neutral point, thereby minimizing the voltage fluctuations present at the terminals of the PV panel....

  15. Classroom Activity Connections: Lessons from Fluorescence

    Science.gov (United States)

    MacCormac, Aoife; O'Brien, Emma; O'Kennedy, Richard

    2010-01-01

    This Classroom Activity Connections paper describes an extension to the "JCE" Classroom Activity #68 "Turning on the Light". A number of additional common items that display fluorescence under UV light are described, including fruits, vegetables, and seashells. Two classroom extensions on fluorescence are also described. From these activities,…

  16. Kähler Quantization and Hitchin Connections

    DEFF Research Database (Denmark)

    Leth Gammelgaard, Niels

    such deformation quantization, which uses Feynman graphs to encode the relevant differential operators. In particular, this yields an explicit formula for the Berezin-Toeplitz star product. For geometric quantization, we consider Andersen's generalization of Hitchin's projectively flat connection to a general...

  17. Graph sharing games: complexity and connectivity

    CERN Document Server

    Cibulka, Josef; Mészáros, Viola; Stolař, Rudolf; Valtr, Pavel

    2012-01-01

    We study the following combinatorial game played by two players, Alice and Bob, which generalizes the Pizza game considered by Brown, Winkler and others. Given a connected graph G with nonnegative weights assigned to its vertices, the players alternately take one vertex of G in each turn. The first turn is Alice's. The vertices are to be taken according to one (or both) of the following two rules: (T) the subgraph of G induced by the taken vertices is connected during the whole game, (R) the subgraph of G induced by the remaining vertices is connected during the whole game. We show that if rules (T) and/or (R) are required then for every epsilon > 0 and for every positive integer k there is a k-connected graph G for which Bob has a strategy to obtain (1-epsilon) of the total weight of the vertices. This contrasts with the original Pizza game played on a cycle, where Alice is known to have a strategy to obtain 4/9 of the total weight. We show that the problem of deciding whether Alice has a winning strategy (i...

  18. Connecting Learning Spaces Using Mobile Technology

    Science.gov (United States)

    Chen, Wenli; Seow, Peter; So, Hyo-Jeong; Toh, Yancy; Looi, Chee-Kit

    2010-01-01

    The use of mobile technology can help extend children's learning spaces and enrich the learning experiences in their everyday lives where they move from one context to another, switching locations, social groups, technologies, and topics. When students have ubiquitous access to mobile devices with full connectivity, the in-situ use of the mobile…

  19. Jubilite: A 4-,8-connected Cubic Structural Pattern in Space Group Pm3

    Directory of Open Access Journals (Sweden)

    Eduardo A. Castro

    2005-05-01

    Full Text Available Abstract: In the course of investigating structural modifications of the 3-,4-connected net known as the Pt3O4 structure-type (waserite, a novel 4-,8-connected structure-type was discovered. This lattice is generated by replacing the 3-connected trigonal planar vertices of the Pt3O4 structure-type with 4-connected tetrahedral vertices, to achieve a structure which possesses a generic empirical formula of JK6L8. In such a topological modification, the four 3-fold axes of the parent cubic, Pm3n, Pt3O4 structure-type are retained. Thus the 4-connected tetrahedral vertices are oriented so as to preserve cubic symmetry in the resulting Pm3, JK6L8 (jubilite lattice. The unit cell contains a single 8-connected cubecentered vertex, six 4-connected distorted square planar vertices and eight 4-connected distorted tetrahedral vertices. It is a Wellsean structure with a Wells point symbol given by (4166484(42826(43838 and a Schläfli symbol of (53/4, 4.2667. This latter index reveals a decrease in the lattice’s polygonality and concomitant increase in the connectivity through the transformation from waserite to jubilite. The topology of the parent waserite lattice (Pt3O4 corresponds to that of the Catalan structures with the Wells point symbol (843(834, which has the Schläfli symbol (8, 3.4285. Finally, it can be seen that a sequence of structure-types starting with waserite (Pt3O4 and moving to jubilite (JK6L8 and finally to fluorite (CaF2 represents a continuous crystallographic structural transformation in which the symmetry and topology undergo concomitant changes from one structure-type (waserite to the other structure-types. The topology of the fluorite lattice, represented by the Wells point symbol (424(462, and the Schläfli symbol (4, 51/3, indicates a discontinuous topological transformation from the intermediate jubilite lattice; like the discontinuous topological transformation from Pt3O4 to JK6L8; in which the

  20. Altered whole-brain connectivity in albinism.

    Science.gov (United States)

    Welton, Thomas; Ather, Sarim; Proudlock, Frank A; Gottlob, Irene; Dineen, Robert A

    2017-02-01

    Albinism is a group of congenital disorders of the melanin synthesis pathway. Multiple ocular, white matter and cortical abnormalities occur in albinism, including a greater decussation of nerve fibres at the optic chiasm, foveal hypoplasia and nystagmus. Despite this, visual perception is largely preserved. It was proposed that this may be attributable to reorganisation among cerebral networks, including an increased interhemispheric connectivity of the primary visual areas. A graph-theoretic model was applied to explore brain connectivity networks derived from resting-state functional and diffusion-tensor magnetic resonance imaging data in 23 people with albinism and 20 controls. They tested for group differences in connectivity between primary visual areas and in summary network organisation descriptors. Main findings were supplemented with analyses of control regions, brain volumes and white matter microstructure. Significant functional interhemispheric hyperconnectivity of the primary visual areas in the albinism group were found (P = 0.012). Tests of interhemispheric connectivity based on the diffusion-tensor data showed no significant group difference (P = 0.713). Second, it was found that a range of functional whole-brain network metrics were abnormal in people with albinism, including the clustering coefficient (P = 0.005), although this may have been driven partly by overall differences in connectivity, rather than reorganisation. Based on the results, it was suggested that changes occur in albinism at the whole-brain level, and not just within the visual processing pathways. It was proposed that their findings may reflect compensatory adaptations to increased chiasmic decussation, foveal hypoplasia and nystagmus. Hum Brain Mapp 38:740-752, 2017. © 2016 Wiley Periodicals, Inc.

  1. Brain connectivity in pathological and pharmacological coma

    Directory of Open Access Journals (Sweden)

    Quentin Noirhomme

    2010-12-01

    Full Text Available Recent studies in patients with disorders of consciousness (DOC tend to support the view that awareness is not related to activity in a single brain region but to thalamo-cortical connectivity in the frontoparietal network. Functional neuroimaging studies have shown preserved albeit disconnected low level cortical activation in response to external stimulation in patients in a vegetative state or unresponsive wakefulness syndrome. While activation of these primary sensory cortices does not necessarily reflect conscious awareness, activation in higher order associative cortices in minimally conscious state patients seems to herald some residual perceptual awareness. PET studies have identified a metabolic dysfunction in a widespread fronto-parietal global neuronal workspace in DOC patients including the midline default mode network, ‘intrinsic’ system, and the lateral frontoparietal cortices or ‘extrinsic system’. Recent studies have investigated the relation of awareness to the functional connectivity within intrinsic and extrinsic networks, and with the thalami in both pathological and pharmacological coma. In brain damaged patients, connectivity in all default network areas was found to be non-linearly correlated with the degree of clinical consciousness impairment, ranging from healthy controls and locked-in syndrome to minimally conscious, vegetative, coma and brain dead patients. Anesthesia-induced loss of consciousness was also shown to correlate with a global decrease in cortico-cortical and thalamo-cortical connectivity in both intrinsic and extrinsic networks, but not in auditory or visual networks. In anesthesia, unconsciousness was also associated with a loss of cross-modal interactions between networks. These results suggest that conscious awareness critically depends on the functional integrity of thalamo-cortical and cortico-cortical frontoparietal connectivity within and between intrinsic and extrinsic brain networks.

  2. Dynamic functional connectivity reveals altered variability in functional connectivity among patients with major depressive disorder

    Science.gov (United States)

    Tornador, Cristian; Falcón, Carles; López‐Solà, Marina; Hernández‐Ribas, Rosa; Pujol, Jesús; Menchón, José M.; Ritter, Petra; Cardoner, Narcis; Soriano‐Mas, Carles; Deco, Gustavo

    2016-01-01

    Abstract Resting‐state fMRI (RS‐fMRI) has become a useful tool to investigate the connectivity structure of mental health disorders. In the case of major depressive disorder (MDD), recent studies regarding the RS‐fMRI have found abnormal connectivity in several regions of the brain, particularly in the default mode network (DMN). Thus, the relevance of the DMN to self‐referential thoughts and ruminations has made the use of the resting‐state approach particularly important for MDD. The majority of such research has relied on the grand averaged functional connectivity measures based on the temporal correlations between the BOLD time series of various brain regions. We, in our study, investigated the variations in the functional connectivity over time at global and local level using RS‐fMRI BOLD time series of 27 MDD patients and 27 healthy control subjects. We found that global synchronization and temporal stability were significantly increased in the MDD patients. Furthermore, the participants with MDD showed significantly increased overall average (static) functional connectivity (sFC) but decreased variability of functional connectivity (vFC) within specific networks. Static FC increased to predominance among the regions pertaining to the default mode network (DMN), while the decreased variability of FC was observed in the connections between the DMN and the frontoparietal network. Hum Brain Mapp 37:2918–2930, 2016. © 2016 Wiley Periodicals, Inc. PMID:27120982

  3. Investigation of Grid-connected Voltage Source Converter Performance under Unbalanced Faults

    DEFF Research Database (Denmark)

    Jia, Jundi; Yang, Guangya; Nielsen, Arne Hejde

    2016-01-01

    Renewable energy sources (RES) and HVDC links are typically interfaced with the grid by power converters, whose performance during grid faults is significantly different from that of traditional synchronous generators. This paper investigates the performance of grid-connected voltage source...... that the performance of VSCs varies with their control strategies. Negative-sequence current control is necessary to restrict converter current in each phase under unbalanced faults. Among presented control strategies, the balanced current control strategy complies with the present voltage support requirement best...... converters (VSCs) under unbalanced faults. Conventional positive-sequence synchronous reference frame (SRF) control is presented first, followed by three different negative-sequence current control strategies considering reactive power injection and converter current limit. The simulation results indicate...

  4. 49 CFR 192.155 - Welded branch connections.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Welded branch connections. 192.155 Section 192.155... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS... connections. Each welded branch connection made to pipe in the form of a single connection, or in a header...

  5. Bayesian analysis of binary sequences

    Science.gov (United States)

    Torney, David C.

    2005-03-01

    This manuscript details Bayesian methodology for "learning by example", with binary n-sequences encoding the objects under consideration. Priors prove influential; conformable priors are described. Laplace approximation of Bayes integrals yields posterior likelihoods for all n-sequences. This involves the optimization of a definite function over a convex domain--efficiently effectuated by the sequential application of the quadratic program.

  6. Gambling strategies for random sequences

    OpenAIRE

    George Davie

    2010-01-01

    There is a general consensus that it is not possible to gamble successfully against a random se-quence. This consensus is based on results from probability theory that all gambling systems arein some sense futile and the idea that at any stage of the sequence, the next outcome is entirelyunpredictable.

  7. DNA Sequencing Sensors: An Overview

    Directory of Open Access Journals (Sweden)

    Jose Antonio Garrido-Cardenas

    2017-03-01

    Full Text Available The first sequencing of a complete genome was published forty years ago by the double Nobel Prize in Chemistry winner Frederick Sanger. That corresponded to the small sized genome of a bacteriophage, but since then there have been many complex organisms whose DNA have been sequenced. This was possible thanks to continuous advances in the fields of biochemistry and molecular genetics, but also in other areas such as nanotechnology and computing. Nowadays, sequencing sensors based on genetic material have little to do with those used by Sanger. The emergence of mass sequencing sensors, or new generation sequencing (NGS meant a quantitative leap both in the volume of genetic material that was able to be sequenced in each trial, as well as in the time per run and its cost. One can envisage that incoming technologies, already known as fourth generation sequencing, will continue to cheapen the trials by increasing DNA reading lengths in each run. All of this would be impossible without sensors and detection systems becoming smaller and more precise. This article provides a comprehensive overview on sensors for DNA sequencing developed within the last 40 years.

  8. PERIODIC COMPLEMENTARY BINARY SEQUENCE PAIRS

    Institute of Scientific and Technical Information of China (English)

    XuChengqian; ZhaoXiaoqun

    2002-01-01

    A new set of binary sequences-Periodic Complementary Binary Sequence Pair (PCSP)is proposed .A new class of block design-Difference Family Pair (DFP)is also proposed .The relationship between PCSP and DFP,the properties and exising conditions of PCSP and the recursive constructions for PCSP are given.

  9. PERIODIC COMPLEMENTARY BINARY SEQUENCE PAIRS

    Institute of Scientific and Technical Information of China (English)

    Xu Chengqian; Zhao Xiaoqun

    2002-01-01

    A new set of binary sequences-Periodic Complementary Binary Sequence Pair (PCSP) is proposed. A new class of block design-Difference Family Pair (DFP) is also proposed.The relationship between PCSP and DFP, the properties and existing conditions of PCSP and the recursive constructions for PCSP are given.

  10. Sequence conserved for subcellular localization

    Science.gov (United States)

    Nair, Rajesh; Rost, Burkhard

    2002-01-01

    The more proteins diverged in sequence, the more difficult it becomes for bioinformatics to infer similarities of protein function and structure from sequence. The precise thresholds used in automated genome annotations depend on the particular aspect of protein function transferred by homology. Here, we presented the first large-scale analysis of the relation between sequence similarity and identity in subcellular localization. Three results stood out: (1) The subcellular compartment is generally more conserved than what might have been expected given that short sequence motifs like nuclear localization signals can alter the native compartment; (2) the sequence conservation of localization is similar between different compartments; and (3) it is similar to the conservation of structure and enzymatic activity. In particular, we found the transition between the regions of conserved and nonconserved localization to be very sharp, although the thresholds for conservation were less well defined than for structure and enzymatic activity. We found that a simple measure for sequence similarity accounting for pairwise sequence identity and alignment length, the HSSP distance, distinguished accurately between protein pairs of identical and different localizations. In fact, BLAST expectation values outperformed the HSSP distance only for alignments in the subtwilight zone. We succeeded in slightly improving the accuracy of inferring localization through homology by fine tuning the thresholds. Finally, we applied our results to the entire SWISS-PROT database and five entirely sequenced eukaryotes. PMID:12441382

  11. Augmented brain function by coordinated reset stimulation with slowly varying sequences

    Directory of Open Access Journals (Sweden)

    Magteld eZeitler

    2015-03-01

    Full Text Available Several brain disorders are characterized by abnormally strong neuronal synchrony. Coordinated Reset (CR stimulation was developed to selectively counteract abnormal neuronal synchrony by desynchronization. For this, phase resetting stimuli are delivered to different subpopulations in a timely coordinated way. In neural networks with spike timing-dependent plasticity CR stimulation may eventually lead to an anti-kindling, i.e. an unlearning of abnormal synaptic connectivity and abnormal synchrony. The spatiotemporal sequence by which all stimulation sites are stimulated exactly once is called the stimulation site sequence, or briefly sequence. So far, in simulations, pre-clinical and clinical applications CR was applied either with fixed sequences or rapidly varying sequences (RVS. In this computational study we show that appropriate repetition of the sequence with occasional random switching to the next sequence may significantly improve the anti-kindling effect of CR. To this end, a sequence is applied many times before randomly switching to the next sequence. This new method is called SVS CR stimulation, i.e. CR with slowly varying sequences. In a neuronal network with strong short-range excitatory and weak long-range inhibitory dynamic couplings SVS CR stimulation turns out to be superior to CR stimulation with fixed sequences or RVS.

  12. Rapid Diagnostics of Onboard Sequences

    Science.gov (United States)

    Starbird, Thomas W.; Morris, John R.; Shams, Khawaja S.; Maimone, Mark W.

    2012-01-01

    Keeping track of sequences onboard a spacecraft is challenging. When reviewing Event Verification Records (EVRs) of sequence executions on the Mars Exploration Rover (MER), operators often found themselves wondering which version of a named sequence the EVR corresponded to. The lack of this information drastically impacts the operators diagnostic capabilities as well as their situational awareness with respect to the commands the spacecraft has executed, since the EVRs do not provide argument values or explanatory comments. Having this information immediately available can be instrumental in diagnosing critical events and can significantly enhance the overall safety of the spacecraft. This software provides auditing capability that can eliminate that uncertainty while diagnosing critical conditions. Furthermore, the Restful interface provides a simple way for sequencing tools to automatically retrieve binary compiled sequence SCMFs (Space Command Message Files) on demand. It also enables developers to change the underlying database, while maintaining the same interface to the existing applications. The logging capabilities are also beneficial to operators when they are trying to recall how they solved a similar problem many days ago: this software enables automatic recovery of SCMF and RML (Robot Markup Language) sequence files directly from the command EVRs, eliminating the need for people to find and validate the corresponding sequences. To address the lack of auditing capability for sequences onboard a spacecraft during earlier missions, extensive logging support was added on the Mars Science Laboratory (MSL) sequencing server. This server is responsible for generating all MSL binary SCMFs from RML input sequences. The sequencing server logs every SCMF it generates into a MySQL database, as well as the high-level RML file and dictionary name inputs used to create the SCMF. The SCMF is then indexed by a hash value that is automatically included in all command

  13. Quantum Exchangeable Sequences of Algebras

    CERN Document Server

    Curran, Stephen

    2008-01-01

    We extend the notion of quantum exchangeability, introduced by K\\"ostler and Speicher in arXiv:0807.0677, to sequences (\\rho_1,\\rho_2,...c) of homomorphisms from an algebra C into a noncommutative probability space (A,\\phi), and prove a free de Finetti theorem: an infinite quantum exchangeable sequence (\\rho_1,\\rho_2,...c) is freely independent and identically distributed with respect to a conditional expectation. As a corollary we obtain a free analogue of the Hewitt Savage zero-one law. As in the classical case, the theorem fails for finite sequences. We give a characterization of finite quantum exchangeable sequences, which can be viewed as a noncommutative analogue of sampling without replacement. We then give an approximation to how far a finite quantum exchangeable sequence is from being freely independent with amalgamation.

  14. Spatiotemporal correlations of aftershock sequences

    CERN Document Server

    Peixoto, Tiago P; Davidsen, Jörn

    2010-01-01

    Aftershock sequences are of particular interest in seismic research since they may condition seismic activity in a given region over long time spans. While they are typically identified with periods of enhanced seismic activity after a large earthquake as characterized by the Omori law, our knowledge of the spatiotemporal correlations between events in an aftershock sequence is limited. Here, we study the spatiotemporal correlations of two aftershock sequences form California (Parkfield and Hector Mine) using the recently introduced concept of "recurrent" events. We find that both sequences have very similar properties and that most of them are captured by the space-time epidemic-type aftershock sequence (ETAS) model if one takes into account catalog incompleteness. However, the stochastic model does not capture the spatiotemporal correlations leading to the observed structure of seismicity on small spatial scales.

  15. Facilitating NCAR Data Discovery by Connecting Related Resources

    Science.gov (United States)

    Rosati, A.

    2012-12-01

    Linking datasets, creators, and users by employing the proper standards helps to increase the impact of funded research. In order for users to find a dataset, it must first be named. Data citations play the important role of giving datasets a persistent presence by assigning a formal "name" and location. This project focuses on the next step of the "name-find-use" sequence: enhancing discoverability of NCAR data by connecting related resources on the web. By examining metadata schemas that document datasets, I examined how Semantic Web approaches can help to ensure the widest possible range of data users. The focus was to move from search engine optimization (SEO) to information connectivity. Two main markup types are very visible in the Semantic Web and applicable to scientific dataset discovery: The Open Archives Initiative-Object Reuse and Exchange (OAI-ORE - www.openarchives.org) and Microdata (HTML5 and www.schema.org). My project creates pilot aggregations of related resources using both markup types for three case studies: The North American Regional Climate Change Assessment Program (NARCCAP) dataset and related publications, the Palmer Drought Severity Index (PSDI) animation and image files from NCAR's Visualization Lab (VisLab), and the multidisciplinary data types and formats from the Advanced Cooperative Arctic Data and Information Service (ACADIS). This project documents the differences between these markups and how each creates connectedness on the web. My recommendations point toward the most efficient and effective markup schema for aggregating resources within the three case studies based on the following assessment criteria: ease of use, current state of support and adoption of technology, integration with typical web tools, available vocabularies and geoinformatic standards, interoperability with current repositories and access portals (e.g. ESG, Java), and relation to data citation tools and methods.

  16. Connect Global Positioning System RF Module

    Science.gov (United States)

    Franklin, Garth W.; Young, Lawrence E.; Ciminera, Michael A.; Tien, Jeffrey Y.; Gorelik, Jacob; Okihiro, Brian Bachman; Koelewyn, Cynthia L.

    2012-01-01

    The CoNNeCT Global Positioning System RF Module (GPSM) slice is part of the JPL CoNNeCT Software Defined Radio (SDR). CoNNeCT is the Communications, Navigation, and Net working reconfigurable Testbed project that is part of NASA's Space Communication and Nav igation (SCaN) Program. The CoNNeCT project is an experimental dem onstration that will lead to the advancement of SDRs and provide a path for new space communication and navigation systems for future NASA exploration missions. The JPL CoNNeCT SDR will be flying on the International Space Station (ISS) in 2012 in support of the SCaN CoNNeCT program. The GPSM is a radio-frequency sampler module (see Figure 1) that directly sub-harmonically samples the filtered GPS L-band signals at L1 (1575.42 MHz), L2 (1227.6 MHz), and L5 (1176.45 MHz). The JPL SDR receives GPS signals through a Dorne & Margolin antenna mounted onto a choke ring. The GPS signal is filtered against interference, amplified, split, and fed into three channels: L1, L2, and L5. In each of the L-band channels, there is a chain of bandpass filters and amplifiers, and the signal is fed through each of these channels to where the GPSM performs a one-bit analog-to-digital conversion (see Figure 2). The GPSM uses a sub-harmonic, single-bit L1, L2, and L5 sampler that samples at a clock rate of 38.656 MHz. The new capability is the down-conversion and sampling of the L5 signal when previous hardware did not provide this capability. The first GPS IIF Satellite was launched in 2010, providing the new L5 signal. With the JPL SDR flying on the ISS, it will be possible to demonstrate navigation solutions with 10-meter 3-D accuracy at 10-second intervals using a field-program mable gate array (FPGA)-based feedback loop running at 50 Hz. The GPS data bits will be decoded and used in the SDR. The GPSM will also allow other waveforms that are installed in the SDR to demonstrate various GNSS tracking techniques.

  17. GlycoCT-a unifying sequence format for carbohydrates.

    Science.gov (United States)

    Herget, S; Ranzinger, R; Maass, K; Lieth, C-W V D

    2008-08-11

    As part of the EUROCarbDB project (www.eurocarbdb.org) we have carefully analyzed the encoding capabilities of all existing carbohydrate sequence formats and the content of publically available structure databases. We have found that none of the existing structural encoding schemata are capable of coping with the full complexity to be expected for experimentally derived structural carbohydrate sequence data across all taxonomic sources. This gap motivated us to define an encoding scheme for complex carbohydrates, named GlycoCT, to overcome the current limitations. This new format is based on a connection table approach, instead of a linear encoding scheme, to describe the carbohydrate sequences, with a controlled vocabulary to name monosaccharides, adopting IUPAC rules to generate a consistent, machine-readable nomenclature. The format uses a block concept to describe frequently occurring special features of carbohydrate sequences like repeating units. It exists in two variants, a condensed form and a more verbose XML syntax. Sorting rules assure the uniqueness of the condensed form, thus making it suitable as a direct primary key for database applications, which rely on unique identifiers. GlycoCT encompasses the capabilities of the heterogeneous landscape of digital encoding schemata in glycomics and is thus a step forward on the way to a unified and broadly accepted sequence format in glycobioinformatics.

  18. Expanding the clinical and genetic heterogeneity of hereditary disorders of connective tissue.

    Science.gov (United States)

    Alazami, Anas M; Al-Qattan, Sarah M; Faqeih, Eissa; Alhashem, Amal; Alshammari, Muneera; Alzahrani, Fatema; Al-Dosari, Mohammed S; Patel, Nisha; Alsagheir, Afaf; Binabbas, Bassam; Alzaidan, Hamad; Alsiddiky, Abdulmonem; Alharbi, Nasser; Alfadhel, Majid; Kentab, Amal; Daza, Riza M; Kircher, Martin; Shendure, Jay; Hashem, Mais; Alshahrani, Saif; Rahbeeni, Zuhair; Khalifa, Ola; Shaheen, Ranad; Alkuraya, Fowzan S

    2016-05-01

    Ehlers-Danlos syndrome (EDS) describes a group of clinical entities in which the connective tissue, primarily that of the skin, joint and vessels, is abnormal, although the resulting clinical manifestations can vary widely between the different historical subtypes. Many cases of hereditary disorders of connective tissue that do not seem to fit these historical subtypes exist. The aim of this study is to describe a large series of patients with inherited connective tissue disorders evaluated by our clinical genetics service and for whom a likely causal variant was identified. In addition to clinical phenotyping, patients underwent various genetic tests including molecular karyotyping, candidate gene analysis, autozygome analysis, and whole-exome and whole-genome sequencing as appropriate. We describe a cohort of 69 individuals representing 40 families, all referred because of suspicion of an inherited connective tissue disorder by their primary physician. Molecular lesions included variants in the previously published disease genes B3GALT6, GORAB, ZNF469, B3GAT3, ALDH18A1, FKBP14, PYCR1, CHST14 and SPARC with interesting variations on the published clinical phenotypes. We also describe the first recessive EDS-like condition to be caused by a recessive COL1A1 variant. In addition, exome capture in a familial case identified a homozygous truncating variant in a novel and compelling candidate gene, AEBP1. Finally, we also describe a distinct novel clinical syndrome of cutis laxa and marked facial features and propose ATP6V1E1 and ATP6V0D2 (two subunits of vacuolar ATPase) as likely candidate genes based on whole-genome and whole-exome sequencing of the two families with this new clinical entity. Our study expands the clinical spectrum of hereditary disorders of connective tissue and adds three novel candidate genes including two that are associated with a highly distinct syndrome.

  19. Differential Effects of Brain Disorders on Structural and Functional Connectivity

    Science.gov (United States)

    Vega-Pons, Sandro; Olivetti, Emanuele; Avesani, Paolo; Dodero, Luca; Gozzi, Alessandro; Bifone, Angelo

    2017-01-01

    Different measures of brain connectivity can be defined based on neuroimaging read-outs, including structural and functional connectivity. Neurological and psychiatric conditions are often associated with abnormal connectivity, but comparing the effects of the disease on different types of connectivity remains a challenge. In this paper, we address the problem of quantifying the relative effects of brain disease on structural and functional connectivity at a group level. Within the framework of a graph representation of connectivity, we introduce a kernel two-sample test as an effective method to assess the difference between the patients and control group. Moreover, we propose a common representation space for structural and functional connectivity networks, and a novel test statistics to quantitatively assess differential effects of the disease on different types of connectivity. We apply this approach to a dataset from BTBR mice, a murine model of Agenesis of the Corpus Callosum (ACC), a congenital disorder characterized by the absence of the main bundle of fibers connecting the two hemispheres. We used normo-callosal mice (B6) as a comparator. The application of the proposed methods to this data-set shows that the two types of connectivity can be successfully used to discriminate between BTBR and B6, meaning that both types of connectivity are affected by ACC. However, our novel test statistics shows that structural connectivity is significantly more affected than functional connectivity, consistent with the idea that functional connectivity has a robust topology that can tolerate substantial alterations in its structural connectivity substrate. PMID:28119556

  20. The Washington Connected Landscapes Project: Providing Analysis Tools for Regional Connectivity and Climate Adaptation Planning

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This project builds on existing work by the Washington Habitat Connectivity Working Group to provide scientific analyses and tools necessary to conserve wildlife...

  1. Connectivity editing for quad-dominant meshes

    KAUST Repository

    Peng, Chihan

    2013-08-01

    We propose a connectivity editing framework for quad-dominant meshes. In our framework, the user can edit the mesh connectivity to control the location, type, and number of irregular vertices (with more or fewer than four neighbors) and irregular faces (non-quads). We provide a theoretical analysis of the problem, discuss what edits are possible and impossible, and describe how to implement an editing framework that realizes all possible editing operations. In the results, we show example edits and illustrate the advantages and disadvantages of different strategies for quad-dominant mesh design. © 2013 The Author(s) Computer Graphics Forum © 2013 The Eurographics Association and John Wiley & Sons Ltd.

  2. Advanced connection systems for architectural glazing

    CERN Document Server

    Afghani Khoraskani, Roham

    2015-01-01

    This book presents the findings of a detailed study to explore the behavior of architectural glazing systems during and after an earthquake and to develop design proposals that will mitigate or even eliminate the damage inflicted on these systems. The seismic behavior of common types of architectural glazing systems are investigated and causes of damage to each system, identified. Furthermore, depending on the geometrical and structural characteristics, the ultimate horizontal load capacity of glass curtain wall systems is defined based on the stability of the glass components. Detailed attention is devoted to the incorporation of advanced connection devices between the structure of the building and the building envelope system in order to minimize the damage to glazed components. An innovative new connection device is introduced that results in a delicate and functional system easily incorporated into different architectural glazing systems, including those demanding maximum transparency.

  3. FEMINISM AND COSMOPOLITANISM: SOME INEVITABLE CONNECTIONS

    Directory of Open Access Journals (Sweden)

    DIANA ELENA NEAGA

    2011-04-01

    Full Text Available In this paper I will approach the issue of feminism and cosmopolitanism in order to give arguments in sustaining the fact that, today, feminism and cosmopolitanism are inevitable connected. In constructing my discourse I will begin by laying out the main ideas of cosmopolitanism, followed by a presentation of the construction of the feminist movement over time, inter-relating these two discourses at the end of the analysis. Connected with political ethics, political theory and political philosophy, the theoretical framework selected for this paper is based on the cosmopolitan theory developed by scholars like Martha Nussbaum, Fiona Robinson and Kwame Anthony Appaih who, underlining universality, define cosmopolitism as a universal concern with every human life and its well-being, but who are also giving value to the differences (seen as cultural or/ and of identity insofar as they are not harmful to people.

  4. FEMINISM AND COSMOPOLITANISM: SOME INEVITABLE CONNECTIONS

    Directory of Open Access Journals (Sweden)

    Diana Elena NEAGA

    2011-08-01

    Full Text Available In this paper I will approach the issue of feminism and cosmopolitanism in order to give arguments in sustaining the fact that, today, feminism and cosmopolitanism are inevitable connected. In constructing my discourse I will begin by laying out the main ideas of cosmopolitanism, followed by a presentation of the construction of the feminist movement over time, inter-relating these two discourses at the end of the analysis. Connected with political ethics, political theory and political philosophy, the theoretical framework selected for this paper is based on the cosmopolitan theory developed by scholars like Martha Nussbaum, Fiona Robinson and Kwame Anthony Appaih who, underlining universality, define cosmopolitism as a universal concern with every human life and its well-being, but who are also giving value to the differences (seen as cultural or/ and of identity insofar as they are not harmful to people.

  5. STATIONARY CONNECTED CURVES IN HILBERT SPACES

    Directory of Open Access Journals (Sweden)

    Raed Hatamleh

    2014-01-01

    Full Text Available In this article the structure of non-stationary curves which are stationary connected in Hilbert space is studied using triangular models of non-self-adjoint operator. The concept of evolutionary representability plays here an important role. It is proved that if one of two curves in Hilbert space is evolutionary representable and the curves are stationary connected, then another curve is evolutionary representable too. These curves are studied firstly. The structure of a cross-correlation function in the case when operator, defining the evolutionary representation, has one-dimensional non-Hermitian subspace (the spectrum is discreet and situated in the upper complex half-plane or has infinite multiplicity at zero (Volterra operator is studied.

  6. Painful connections: densification versus fibrosis of fascia.

    Science.gov (United States)

    Pavan, Piero G; Stecco, Antonio; Stern, Robert; Stecco, Carla

    2014-01-01

    Deep fascia has long been considered a source of pain, secondary to nerve pain receptors becoming enmeshed within the pathological changes to which fascia are subject. Densification and fibrosis are among such changes. They can modify the mechanical properties of deep fasciae and damage the function of underlying muscles or organs. Distinguishing between these two different changes in fascia, and understanding the connective tissue matrix within fascia, together with the mechanical forces involved, will make it possible to assign more specific treatment modalities to relieve chronic pain syndromes. This review provides an overall description of deep fasciae and the mechanical properties in order to identify the various alterations that can lead to pain. Diet, exercise, and overuse syndromes are able to modify the viscosity of loose connective tissue within fascia, causing densification, an alteration that is easily reversible. Trauma, surgery, diabetes, and aging alter the fibrous layers of fasciae, leading to fascial fibrosis.

  7. Nevos de tejido conectivo Connective tissue nevi

    Directory of Open Access Journals (Sweden)

    RE Achenbach

    Full Text Available Comunicamos dos casos de nevo del tejido conectivo, el primero con patrón histológico mixto y el segundo con predominio de alteraciones en las fibras elásticas. No se constataron síndromes ni patología sistémica asociada. Un caso presentó disposición linear y un nevo acrómico asociado.Two cases of connective tissue nevi are reported, one of them with a mixed histopatologic pattern and one with elastin fibers diminished. None of the patients had systemic involvement or associated syndromes. The mixed connective tissue nevi type showed a linear distribution and has associated an acromic nevi.

  8. Nuclei, Primes and the Random Matrix Connection

    Directory of Open Access Journals (Sweden)

    Steven J. Miller

    2009-09-01

    Full Text Available In this article, we discuss the remarkable connection between two very different fields, number theory and nuclear physics. We describe the essential aspects of these fields, the quantities studied, and how insights in one have been fruitfully applied in the other. The exciting branch of modern mathematics – random matrix theory – provides the connection between the two fields. We assume no detailed knowledge of number theory, nuclear physics, or random matrix theory; all that is required is some familiarity with linear algebra and probability theory, as well as some results from complex analysis. Our goal is to provide the inquisitive reader with a sound overview of the subjects, placing them in their historical context in a way that is not traditionally given in the popular and technical surveys.

  9. Connectivity and the Origin of Inertia

    CERN Document Server

    Nickisch, L J; Mollere, Jules

    2002-01-01

    Newton's Second Law defines inertial mass as the ratio of the applied force on an object to the responding acceleration of the object (viz., F=ma). Objects that exhibit finite accelerations under finite forces are described as being "massive'' and this mass has usually been considered to be an innate property of the particles composing the object. However mass itself is never directly measured. It is inertia, the reaction of the object to impressed forces, that is measured. We show that the effects of inertia are equally well explained as a consequence of the vacuum fields acting on massless particles travelling in geodesic motion. In this approach, the vacuum fields in the particle's history define the curvature of the particle's spacetime. The metric describing this curvature implies a transformation to Minkowski spacetime, which we call the Connective transformation. Application of the Connective transformation produces the usual effects of inertia when observed in Minkowski spacetime, including hyperbolic...

  10. Sociology: a lost connection in social psychology.

    Science.gov (United States)

    Oishi, Shigehiro; Kesebir, Selin; Snyder, Benjamin H

    2009-11-01

    For the first half of the 20th century, sociology was one of the closest allies of social psychology. Over the past four decades, however, the connection with sociology has weakened, whereas new connections with neighboring disciplines (e.g., biology, economics, political science) have formed. Along the way, the sociological perspective has been largely lost in mainstream social psychology in the United States. Most social psychologists today are not concerned with collective phenomena and do not investigate social structural factors (e.g., residential mobility, socioeconomic status, dominant religion, political systems). Even when the social structural factors are included in the analysis, psychologists typically treat them as individual difference variables. Sociologist C. Wright Mills famously promoted sociological imagination, or the ability to see distal yet important social forces operating in a larger societal context. By comparing sociological perspectives to psychological perspectives, this article highlights the insights that the sociological perspective and sociological imagination can bring to social psychology.

  11. Modifying network connectivity with a subgraph addition

    CERN Document Server

    Taylor, Dane

    2011-01-01

    The principal eigenvalue $\\lambda$ of a network's adjacency matrix often determines dynamics on the network (e.g., in synchronization and spreading processes) and some of its structural properties (e.g., robustness against failure or attack), and is therefore a good indicator for how "strongly" a network is connected. We study how $\\lambda$ is modified by the addition of a subgraph. This type of modification has broad applications, ranging from those involving a single modification (e.g., introduction of a drug into a biological process) to those involving repeated subnetwork additions (e.g., power-grid and transit development). We describe how to optimally connect the subgraph to the network to either maximize or minimize the shift in $\\lambda$, noting several applications.

  12. Autodesk发布Inventor Connected Design

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    2015年12月,欧特克公司宣布针对Inventor维护合约用户推出新的协作工具Inventor Connected Design.Inventor Connected Design将Inventor连入云端运算平台,用户可透过AutodeskA360,轻易地在Inventor中进行“设计分享协作会议”,进行设计标注,辅助、推动和记录设计决策的过程,同时管理设计的各项资源.通过云端,多个工程团队可跨越产品开发工作流程开展协作,加快决策流程.

  13. Disturbed Interhemispheric Functional Connectivity Rather than Structural Connectivity in Irritable Bowel Syndrome

    Directory of Open Access Journals (Sweden)

    Rongfeng Qi

    2016-12-01

    Full Text Available Neuroimaging studies have demonstrated that irritable bowel syndrome (IBS—a relapsing functional bowel disorder—presents with disrupted brain connections. However, little is known about the alterations of interhemispheric functional connectivity and underlying structural connectivity in IBS. This study combined resting-state functional magnetic resonance imaging (MRI and diffusion tensor imaging (DTI to investigate changes in interhemispheric coordination in IBS patients. Resting-state functional and structural magnetic resonance images were acquired from 65 IBS patients and 67 healthy controls (matched for age, sex and educational level. Interhemispheric voxel-mirrored homotopic connectivity (VMHC was calculated and compared between groups. Homotopic regions showing abnormal VMHC in patients were targeted as regions of interest for analysis of DTI tractography. The fractional anisotropy, fiber number, and fiber length were compared between groups. Statistical analysis was also performed by including anxiety and depression as covariates to evaluate their effect. A Pearson correlation analysis between abnormal interhemispheric connectivity and clinical indices of IBS patients was performed. Compared to healthy controls, IBS patients had higher interhemispheric functional connectivity between bilateral thalami, cuneus, posterior cingulate cortices, lingual gyri and inferior occipital/cerebellum lobes, as well as lower interhemispheric functional connectivity between bilateral ventral anterior cingulate cortices (vACC and inferior parietal lobules (IPL. The inclusion of anxiety and depression as covariates abolished VMHC difference in vACC. Microstructural features of white matter tracts connecting functionally abnormal regions did not reveal any differences between the groups. VMHC values in vACC negatively correlated with the quality of life scores of patients. In conclusion, this study provides preliminary evidence of the disrupted

  14. Radio Loud AGN Unification: Connecting Jets and Accretion

    Directory of Open Access Journals (Sweden)

    Meyer Eileen T.

    2013-12-01

    Full Text Available While only a fraction of Active Galactic Nuclei are observed to host a powerful relativistic jet, a cohesive picture is emerging that radio-loud AGN may represent an important phase in the evolution of galaxies and the growth of the central super-massive black hole. I will review my own recent observational work in radio-loud AGN unification in the context of understanding how and why jets form and their the connection to different kinds of accretion and growing the black hole, along with a brief discussion of possible connections to recent modeling work in jet formation. Starting from the significant observational advances in our understanding of jetted AGN as a population over the last decade thanks to new, more sensitive instruments such as Fermi and Swift as well as all-sky surveys at all frequencies, I will lay out the case for a dichotomy in the jetted AGN population connected to accretion mode onto the black hole. In recent work, we have identified two sub-populations of radio-loud AGN which appear to be distinguished by jet structure, where low-efficiency accreting systems produce ‘weak’ jets which decelerate more rapidly than the ’strong’ jets of black holes accreting near the Eddington limit. The two classes are comprised of: (1The weak jet sources, corresponding to the less collimated, edge-darkened FR Is, with a decelerating or spine-sheath jet with velocity gradients, and (2 The strong jet sources, having fast, collimated jets, and typically displaying strong emission lines. The dichotomy in the vp-Lp plane can be understood as a "broken power sequence" in which jets exist on one branch or the other based on the particular accretion mode (Georganopolous 2011.We suggest that the intrinsic kinetic power (as measured by low-frequency, isotropic radio emission, the orientation, and the accretion rate of the SMBH system are the the fundamental axes needed for unification of radio-loud AGN by studying a well-characterized sample

  15. Multilocus Sequence Typing of Total-Genome-Sequenced Bacteria

    DEFF Research Database (Denmark)

    Larsen, Mette Voldby; Cosentino, Salvatore; Rasmussen, Simon

    2012-01-01

    Accurate strain identification is essential for anyone working with bacteria. For many species, multilocus sequence typing (MLST) is considered the "gold standard" of typing, but it is traditionally performed in an expensive and time-consuming manner. As the costs of whole-genome sequencing (WGS......) continue to decline, it becomes increasingly available to scientists and routine diagnostic laboratories. Currently, the cost is below that of traditional MLST. The new challenges will be how to extract the relevant information from the large amount of data so as to allow for comparison over time...... and between laboratories. Ideally, this information should also allow for comparison to historical data. We developed a Web-based method for MLST of 66 bacterial species based on WGS data. As input, the method uses short sequence reads from four sequencing platforms or preassembled genomes. Updates from...

  16. Ossification sequence heterochrony among amphibians.

    Science.gov (United States)

    Harrington, Sean M; Harrison, Luke B; Sheil, Christopher A

    2013-01-01

    Heterochrony is an important mechanism in the evolution of amphibians. Although studies have centered on the relationship between size and shape and the rates of development, ossification sequence heterochrony also may have been important. Rigorous, phylogenetic methods for assessing sequence heterochrony are relatively new, and a comprehensive study of the relative timing of ossification of skeletal elements has not been used to identify instances of sequence heterochrony across Amphibia. In this study, a new version of the program Parsimov-based genetic inference (PGi) was used to identify shifts in ossification sequences across all extant orders of amphibians, for all major structural units of the skeleton. PGi identified a number of heterochronic sequence shifts in all analyses, the most interesting of which seem to be tied to differences in metamorphic patterns among major clades. Early ossification of the vomer, premaxilla, and dentary is retained by Apateon caducus and members of Gymnophiona and Urodela, which lack the strongly biphasic development seen in anurans. In contrast, bones associated with the jaws and face were identified as shifting late in the ancestor of Anura. The bones that do not shift late, and thereby occupy the earliest positions in the anuran cranial sequence, are those in regions of the skull that undergo the least restructuring throughout anuran metamorphosis. Additionally, within Anura, bones of the hind limb and pelvic girdle were also identified as shifting early in the sequence of ossification, which may be a result of functional constraints imposed by the drastic metamorphosis of most anurans.

  17. The Internet of things connecting objects

    CERN Document Server

    Chaouchi, Hakima

    2013-01-01

    Internet of Things: Connecting Objects… puts forward the technologies and the networking architectures which make it possible to support the Internet of Things. Amongst these technologies, RFID, sensor and PLC technologies are described and a clear view on how they enable the Internet of Things is given. This book also provides a good overview of the main issues facing the Internet of Things such as the issues of privacy and security, application and usage, and standardization.

  18. Eccentric Connectivity Index of Chemical Trees

    CERN Document Server

    c, Aleksandar Ili\\'

    2011-01-01

    The eccentric connectivity index $\\xi^c$ is a distance--based molecular structure descriptor that was recently used for mathematical modeling of biological activities of diverse nature. We prove that the broom has maximum $\\xi^c$ among trees with a fixed maximum vertex degree, and characterize such trees with minimum $\\xi^c$\\,. In addition, we propose a simple linear algorithm for calculating $\\xi^c$ of trees.

  19. Connection matrices for ultradiscrete linear problems

    Energy Technology Data Exchange (ETDEWEB)

    Ormerod, Chris [School of Mathematics and Statistics F07, The University of Sydney, Sydney (Australia)

    2007-10-19

    We present theory outlining associated linear problems for ultradiscrete equations. The appropriate domain for these problems is the max-plus semiring. Our main result is that despite the restrictive nature of the max-plus semiring, it is still possible to define a theory of connection matrices analogous to that of Birkhoff and his school for systems of linear difference equations. We use such theory to provide evidence for the integrability of an ultradiscrete difference equation.

  20. Careers, Connections and Corruption Risks in Europe

    DEFF Research Database (Denmark)

    Charron, Nicholas; Dahlström, Carl; Fazekas, Mihály

    the interplay between politics and bureaucracy. It suggests that corruption risks are minimized when the two groups involved in decision-making on public contracts—politicians and bureau-crats—have known different interests. This is institutionalized when politicians are accountable to the electorate, while.......4 million procurement contracts. Both show a remarkable sub-national variation across Europe. The study finds corruption risks significantly lower where bureau-crats’ careers do not depend on political connections....

  1. Connecting strangers at a train station

    DEFF Research Database (Denmark)

    Serafin, Stefania; Böttcher, Niels; Pellarin, Lars

    2005-01-01

    In this paper we describe a virtual instrument or a performance space, placed at Høje Tåstrup train station in Denmark, which is meant to establish communicative connections between strangers, by letting users of the system create soundscapes together across the rails. We discuss mapping...... to the development of an interactive installation which takes place in Hoje Taastrup train station in Denmark....

  2. Connections Between Singular Control and Optimal Switching

    OpenAIRE

    Guo, Xin; Tomecek, Pascal

    2007-01-01

    This paper builds a new theoretical connection between singular control of finite variation and optimal switching problems. This correspondence provides a novel method for solving high-dimensional singular control problems, and enables us to extend the theory of reversible investment: sufficient conditions are derived for the existence of optimal controls and for the regularity of value functions. Consequently, our regularity result links singular controls and Dynkin games through sequential ...

  3. Connection between Interception and Political Scene

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    <正>Interception can shake Murdoch’s the News Corporation;can also make the president of a country quit the political scene;even can trigger a coup.There’s no exaggeration. Only knowing yourself as well as the enemy,then you can fight a hundred battles with no danger of defeat. But how can one know the enemy? Interception is the most powerful tool. It is doomed to have connection with political scene ever since its birth.

  4. Connecting to Thermocouples with Fewer Lead Wires

    Science.gov (United States)

    Goldsby, Jon C.

    2003-01-01

    A simple technique has been devised to reduce the number of lead wires needed to connect an array of thermocouples to the instruments (e.g., voltmeters) used to read their output voltages. Because thermocouple wires are usually made of expensive metal alloys, reducing the number of lead wires can effect a considerable reduction in the cost of such an array. Reducing the number of wires also reduces the number of terminals and the amount of space needed to accommodate the wires.

  5. Polyimides containing amide and perfluoroisopropylidene connecting groups

    Science.gov (United States)

    Dezern, James F. (Inventor)

    1993-01-01

    New, thermooxidatively stable polyimides were prepared from the reaction of aromatic dianhydrides containing isopropylidene bridging groups with aromatic diamines containing amide connecting groups between the rings. Several of these polyimides were shown to be semi-crystalline as evidenced by wide angle x ray scattering and differential scanning calorimetry. Most of the polyimides form tough, flexible films with high tensile properties. These polyimide films exhibit enhanced solubility in organic solvents.

  6. Connecting care competencies and culture during disasters

    Directory of Open Access Journals (Sweden)

    Chhabra Vivek

    2009-01-01

    Full Text Available Connecting care Competencies and Culture are core fundamentals in responding to disasters. Thick coordination between professionals, communities and agencies in different geographical areas is crucial to the happening of appropriate preparedness and thus efficient response and mitigation of a disaster. In the next few articles, we present diverse examples related to the preparedness and recovery process to adverse disasters across the globe

  7. Seychelles Fisheries Connectivity and Transport Pathways

    Science.gov (United States)

    2015-09-30

    Plateau. • Identification of physical oceanographic controls on mass and momentum transport on scales that are relevant to local ecology and fisheries and...that determine biological connectivity amongst the Seychelles’ multiple islands. • Collection of observational data that will provide validation...capabilities for flow in complex environments. Figure 1. Region of interest and proposed model grid. Regional map includes the coastlines of Madagascar

  8. Geological connectivity drives microbial community structure and connectivity in polar, terrestrial ecosystems.

    Science.gov (United States)

    Ferrari, Belinda C; Bissett, Andrew; Snape, Ian; van Dorst, Josie; Palmer, Anne S; Ji, Mukan; Siciliano, Steven D; Stark, Jonathon S; Winsley, Tristrom; Brown, Mark V

    2016-06-01

    Landscape heterogeneity impacts community assembly in animals and plants, but it is not clear if this ecological concept extends to microbes. To examine this question, we chose to investigate polar soil environments from the Antarctic and Arctic, where microbes often form the major component of biomass. We examined soil environments that ranged in connectivity from relatively well-connected slopes to patchy, fragmented landforms that comprised isolated frost boils. We found landscape connectedness to have a significant correlation with microbial community structure and connectivity, as measured by co-occurrence networks. Soils from within fragmented landforms appeared to exhibit less local environmental heterogeneity, harboured more similar communities, but fewer biological associations than connected landforms. This effect was observed at both poles, despite the geographical distances and ecological differences between them. We suggest that microbial communities inhabiting well-connected landscape elements respond consistently to regional-scale gradients in biotic and edaphic factors. Conversely, the repeated freeze thaw cycles that characterize fragmented landscapes create barriers within the landscape and act to homogenize the soil environment within individual frost boils and consequently the microbial communities. We propose that lower microbial connectivity in the fragmented landforms is a function of smaller patch size and continual disturbances following soil mixing.

  9. Impaired thalamocortical connectivity in autism spectrum disorder: a study of functional and anatomical connectivity.

    Science.gov (United States)

    Nair, Aarti; Treiber, Jeffrey M; Shukla, Dinesh K; Shih, Patricia; Müller, Ralph-Axel

    2013-06-01

    The thalamus plays crucial roles in the development and mature functioning of numerous sensorimotor, cognitive and attentional circuits. Currently limited evidence suggests that autism spectrum disorder may be associated with thalamic abnormalities, potentially related to sociocommunicative and other impairments in this disorder. We used functional connectivity magnetic resonance imaging and diffusion tensor imaging probabilistic tractography to study the functional and anatomical integrity of thalamo-cortical connectivity in children and adolescents with autism spectrum disorder and matched typically developing children. For connectivity with five cortical seeds (prefontal, parieto-occipital, motor, somatosensory and temporal), we found evidence of both anatomical and functional underconnectivity. The only exception was functional connectivity with the temporal lobe, which was increased in the autism spectrum disorders group, especially in the right hemisphere. However, this effect was robust only in partial correlation analyses (partialling out time series from other cortical seeds), whereas findings from total correlation analyses suggest that temporo-thalamic overconnectivity in the autism group was only relative to the underconnectivity found for other cortical seeds. We also found evidence of microstructural compromise within the thalamic motor parcel, associated with compromise in tracts between thalamus and motor cortex, suggesting that the thalamus may play a role in motor abnormalities reported in previous autism studies. More generally, a number of correlations of diffusion tensor imaging and functional connectivity magnetic resonance imaging measures with diagnostic and neuropsychological scores indicate involvement of abnormal thalamocortical connectivity in sociocommunicative and cognitive impairments in autism spectrum disorder.

  10. Microgravity Stress: Bone and Connective Tissue.

    Science.gov (United States)

    Bloomfield, Susan A; Martinez, Daniel A; Boudreaux, Ramon D; Mantri, Anita V

    2016-03-15

    The major alterations in bone and the dense connective tissues in humans and animals exposed to microgravity illustrate the dependency of these tissues' function on normal gravitational loading. Whether these alterations depend solely on the reduced mechanical loading of zero g or are compounded by fluid shifts, altered tissue blood flow, radiation exposure, and altered nutritional status is not yet well defined. Changes in the dense connective tissues and intervertebral disks are generally smaller in magnitude but occur more rapidly than those in mineralized bone with transitions to 0 g and during recovery once back to the loading provided by 1 g conditions. However, joint injuries are projected to occur much more often than the more catastrophic bone fracture during exploration class missions, so protecting the integrity of both tissues is important. This review focuses on the research performed over the last 20 years in humans and animals exposed to actual spaceflight, as well as on knowledge gained from pertinent ground-based models such as bed rest in humans and hindlimb unloading in rodents. Significant progress has been made in our understanding of the mechanisms for alterations in bone and connective tissues with exposure to microgravity, but intriguing questions remain to be solved, particularly with reference to biomedical risks associated with prolonged exploration missions.

  11. Stretching Impacts Inflammation Resolution in Connective Tissue.

    Science.gov (United States)

    Berrueta, Lisbeth; Muskaj, Igla; Olenich, Sara; Butler, Taylor; Badger, Gary J; Colas, Romain A; Spite, Matthew; Serhan, Charles N; Langevin, Helene M

    2016-07-01

    Acute inflammation is accompanied from its outset by the release of specialized pro-resolving mediators (SPMs), including resolvins, that orchestrate the resolution of local inflammation. We showed earlier that, in rats with subcutaneous inflammation of the back induced by carrageenan, stretching for 10 min twice daily reduced inflammation and improved pain, 2 weeks after carrageenan injection. In this study, we hypothesized that stretching of connective tissue activates local pro-resolving mechanisms within the tissue in the acute phase of inflammation. In rats injected with carrageenan and randomized to stretch versus no stretch for 48 h, stretching reduced inflammatory lesion thickness and neutrophil count, and increased resolvin (RvD1) concentrations within lesions. Furthermore, subcutaneous resolvin injection mimicked the effect of stretching. In ex vivo experiments, stretching of connective tissue reduced the migration of neutrophils and increased tissue RvD1 concentration. These results demonstrate a direct mechanical impact of stretching on inflammation-regulation mechanisms within connective tissue.

  12. Connectivity and synchronization of Vicsek model

    Institute of Scientific and Technical Information of China (English)

    LIU ZhiXin; GUO Lei

    2008-01-01

    The collective behavior of multi-agent systems is an important studying point for the investigation of complex systems,and a basic model of multi-agent systems is the so called Vicsek model,which possesses some key features of complex systems,such as dynamic behavior,local interaction,changing neighborhood,etc.This model looks simple,but the nonlinearly coupled relationship makes the theoretical analysis quite complicated.Jadbabaie et al.analyzed the linearized heading equations in this model and showed that all agents will synchronize eventually,provided that the neighbor graphs associated with the agents' positions satisfy a certain connectivity condition.Much subsequent research effort has been devoted to the analysis of the Vicsek model since the publication of Jadbabaie's work.However,an unresolved key problem is when such a connectivity is satisfied.This paper given a sufficient condition to guarantee the synchronization of the Vicsek model,which is imposed on the model parameters only.Moreover,some counterexamples are given to show that the connectivity of the neighbor graphs is not sufficient for synchronization of the Vicsek model if the initial headings are allowed to be in [0,2π),which reveals some fundamental differences between the Vicsek model and its linearized version.

  13. Multiple neural representations of elementary logical connectives.

    Science.gov (United States)

    Baggio, Giosuè; Cherubini, Paolo; Pischedda, Doris; Blumenthal, Anna; Haynes, John-Dylan; Reverberi, Carlo

    2016-07-15

    A defining trait of human cognition is the capacity to form compounds out of simple thoughts. This ability relies on the logical connectives AND, OR and IF. Simple propositions, e.g., 'There is a fork' and 'There is a knife', can be combined in alternative ways using logical connectives: e.g., 'There is a fork AND there is a knife', 'There is a fork OR there is a knife', 'IF there is a fork, there is a knife'. How does the brain represent compounds based on different logical connectives, and how are compounds evaluated in relation to new facts? In the present study, participants had to maintain and evaluate conjunctive (AND), disjunctive (OR) or conditional (IF) compounds while undergoing functional MRI. Our results suggest that, during maintenance, the left posterior inferior frontal gyrus (pIFG, BA44, or Broca's area) represents the surface form of compounds. During evaluation, the left pIFG switches to processing the full logical meaning of compounds, and two additional areas are recruited: the left anterior inferior frontal gyrus (aIFG, BA47) and the left intraparietal sulcus (IPS, BA40). The aIFG shows a pattern of activation similar to pIFG, and compatible with processing the full logical meaning of compounds, whereas activations in IPS differ with alternative interpretations of conditionals: logical vs conjunctive. These results uncover the functions of a basic cortical network underlying human compositional thought, and provide a shared neural foundation for the cognitive science of language and reasoning.

  14. Behavior of Industrial Steel Rack Connections

    Science.gov (United States)

    Shah, S. N. R.; Ramli Sulong, N. H.; Khan, R.; Jumaat, M. Z.; Shariati, M.

    2016-03-01

    Beam-to-column connections (BCCs) used in steel pallet racks (SPRs) play a significant role to maintain the stability of rack structures in the down-aisle direction. The variety in the geometry of commercially available beam end connectors hampers the development of a generalized analytic design approach for SPR BCCs. The experimental prediction of flexibility in SPR BCCs is prohibitively expensive and difficult for all types of commercially available beam end connectors. A suitable solution to derive a particular uniform M-θ relationship for each connection type in terms of geometric parameters may be achieved through finite element (FE) modeling. This study first presents a comprehensive description of the experimental investigations that were performed and used as the calibration bases for the numerical study that constituted its main contribution. A three dimensioned (3D) non-linear finite element (FE) model was developed and calibrated against the experimental results. The FE model took into account material nonlinearities, geometrical properties and large displacements. Comparisons between numerical and experimental data for observed failure modes and M-θ relationship showed close agreement. The validated FE model was further extended to perform parametric analysis to identify the effects of various parameters which may affect the overall performance of the connection.

  15. Exploring brain function from anatomical connectivity

    Directory of Open Access Journals (Sweden)

    Gorka eZamora-López

    2011-06-01

    Full Text Available The intrinsic relationship between the architecture of the brain and the range of sensory and behavioral phenomena it produces is a relevant question in neuroscience. Here, we review recent knowledge gained on the architecture of the anatomical connectivity by means of complex network analysis. It has been found that corticocortical networks display a few prominent characteristics: (i modular organization, (ii abundant alternative processing paths and (iii the presence of highly connected hubs. Additionally, we present a novel classification of cortical areas of the cat according to the role they play in multisensory connectivity. All these properties represent an ideal anatomical substrate supporting rich dynamical behaviors, as-well-as facilitating the capacity of the brain to process sensory information of different modalities segregated and to integrate them towards a comprehensive perception of the real world. The result here exposed are mainly based in anatomical data of cats’ brain, but we show how further observations suggest that, from worms to humans, the nervous system of all animals might share fundamental principles of organization.

  16. The connection revisited; De aansluiting revisited

    Energy Technology Data Exchange (ETDEWEB)

    Janssen, J.E.

    2009-10-15

    A previous article of this journal (NTE 2006, no 5, pp 155-164) was dedicated to the connection in the Dutch Electricity Act 1998. Since then there have been several amendments in regulation, decisions and jurisprudence to justify a follow-up article. This article aims to provide a thematic overview of the developments in Dutch regulation, NMa decisions and jurisprudence with regard to electricity and gas connection in the last three years, linking up to the themes addresses in the above-mentioned article. The focus is broadened to connections under the Electricity Act and the Gas Act. [Dutch] In een vorig artikel van dit tijdschrift (NTE 2006, no. 5, p. 155-164) is aandacht besteed aan de aansluiting in de Elektriciteitswet 1998 (de E-wet). Sinds die tijd is er in de regelgeving, beschikkingspraktijk en jurisprudentie genoeg gewijzigd om een vervolg te rechtvaardigen. Dit artikel beoogt een thematisch overzicht te geven van de ontwikkelingen in de regelgeving, de beschikkingspraktijk van de NMa en jurisprudentie met betrekking tot de elektriciteits- en gasaansluiting in de laatste drie jaar. Daarbij is waar mogelijk aangeknoopt bij de thema's in het hierboven genoemde artikel. De focus is verbreed naar aansluitingen onder zowel de E-wet als de Gaswet.

  17. Intrusion Detection with Multi-Connected Representation

    Directory of Open Access Journals (Sweden)

    Abdelkader Khobzaoui

    2016-01-01

    Full Text Available Recently, considerable attention has been given to data mining techniques to improve the performance of intrusion detection systems (IDS. This has led to the application of various classification and clustering techniques for the purpose of intrusion detection. Most of them assume that behaviors, both normal and intrusions, are represented implicitly by connected classes. We state that such assumption isn't evident and is a source of the low detection rate and false alarm. This paper proposes a suitable method able to reach high detection rate and overcomes the disadvantages of conventional approaches which consider that behaviors must be closed to connected representation only. The main strategy of the proposed method is to segment sufficiently each behavior representation by connected subsets called natural classes which are used, with a suitable metric, as tools to build the expected classifier. The results show that the proposed model has many qualities compared to conventional models; especially regarding those have used DARPA data set for testing the effectiveness of their methods. The proposed model provides decreased rates both for false negative rates and for false positives.

  18. Schizophrenia, abnormal connection, and brain evolution.

    Science.gov (United States)

    Randall, P L

    1983-03-01

    Abnormalities of functional connection between specialized areas in the human brain may underlie the symptoms which constitute the schizophrenia syndrome. Callosal and intrahemispheric fibres may be equally involved. The clinical emergence of symptoms in the later stages of brain maturation may be dependent on myelination of these fibre groups, both of which have extended myelination cycles. Ontogenetically earlier variants of the same mechanism could theoretically result in dyslexia and the syndromes of Kanner and Gilles de la Tourette. As new and unique extensions of specialized function emerge within the evolving brain, biological trial and error of connection both within and between them may produce individuals possessing phylogenetically advanced abilities, or equally, others possessing a wide range of abnormalities including those which comprise the schizophrenia syndrome. A dormant phenotypic potential for schizophrenia may exist in individuals who never develop symptoms during the course of a lifetime though some of these may become clinically apparent under the influence of various precipitating factors. It is concluded that abnormal functional connection and its normal and "supernormal" counterparts may be natural, essential, and inevitable consequences of brain evolution, and that this may have been so throughout the history of vertebrate brain evolution.

  19. Long-Range Connections in Transportation Networks

    CERN Document Server

    Viana, Matheus P

    2010-01-01

    Since its recent introduction, the small-world effect has been identified in several important real-world systems. Frequently, it is a consequence of the existence of a few long-range connections, which dominate the original regular structure of the systems and implies each node to become accessible from other nodes after a small number of steps, typically of order $\\ell \\propto \\log N$. However, this effect has been observed in pure-topological networks, where the nodes have no spatial coordinates. In this paper, we present an alalogue of small-world effect observed in real-world transportation networks, where the nodes are embeded in a hree-dimensional space. Using the multidimensional scaling method, we demonstrate how the addition of a few long-range connections can suubstantially reduce the travel time in transportation systems. Also, we investigated the importance of long-range connections when the systems are under an attack process. Our findings are illustrated for two real-world systems, namely the L...

  20. Criminologyof the future: interdisciplinary scientific connections

    Directory of Open Access Journals (Sweden)

    Antonyan Yu.M.

    2014-12-01

    Full Text Available The results of interdisciplinary scientific connections of the modern criminology conditional on the open character of this science and the necessity of its further development are given. The narrow-purpose character of criminological researches is noted: trivial subject matter; the criminologists’ lack of psychological, psychiatric, economical, historical, biological, ethnological and other knowledge; insufficiency of complex interdisciplinary works and empirical studies. Different viewpoints on the type of criminologists’ education are analyzed. That emphasizes the necessity of cooperation between criminology and other sciences, such as: sociology, demography, culturology, psychology, economics, pedagogics, psychiatry, ethnology, history, biology, political science, philosophy and others. The phenomenon of criminology is argued: it studies a “bad”, criminal, immoral person unlike other sciences (it belongs to the number of sciences which object is person. The main parameter of criminology as a science is examined – its subject which allows to distinguish it from other legal disciplines especially from criminal law. New aspects of interconnection between criminology and criminal procedure, criminalistics, the theory of investigation activity and criminal executive law are shown. The stable connections with family law, banking law, financial law and administrative law are considered. The author emphasizes the significant potential of developing criminology in its connection with nonlegal sciences: sociology, psychiatry, economics, statistics, psychology (including criminal psychology, biology and philosophy. It is noted that prospects and progress of criminology are possible only in its cooperation with other sciences.