WorldWideScience

Sample records for biomolecules equipment design

  1. Margins related to equipment design

    International Nuclear Information System (INIS)

    Safety margins related to design of reactor equipment are defined according to safety regulations. Advanced best estimate methods are proposed including some examples which were computed and compared to experimental results. Best estimate methods require greater computation effort and more material data but give better variable accuracy and need careful experimental validation. Simplified methods compared to the previous are less sensitive to material data, sometimes are more accurate but very long to elaborate

  2. 40 CFR 160.61 - Equipment design.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Equipment design. 160.61 Section 160... LABORATORY PRACTICE STANDARDS Equipment § 160.61 Equipment design. Equipment used in the generation... appropriate design and adequate capacity to function according to the protocol and shall be suitably...

  3. 40 CFR 792.61 - Equipment design.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 31 2010-07-01 2010-07-01 true Equipment design. 792.61 Section 792.61...) GOOD LABORATORY PRACTICE STANDARDS Equipment § 792.61 Equipment design. Equipment used in the... of appropriate design and adequate capacity to function according to the protocol and shall...

  4. 21 CFR 58.61 - Equipment design.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Equipment design. 58.61 Section 58.61 Food and... PRACTICE FOR NONCLINICAL LABORATORY STUDIES Equipment § 58.61 Equipment design. Equipment used in the... of appropriate design and adequate capacity to function according to the protocol and shall...

  5. Engineering of scintigraphy equipment - the basic design

    International Nuclear Information System (INIS)

    Basic design of scintigraphy equipment for imaging small organs has been made. The equipment is a mini gamma camera. The function of the equipment is provide images of metabolism process in a body organ. The result of the equipment can be used to diagnose an illness. Radiation detection from a body organ is designed using single scintillation crystal detector which is coupled to a position sensitive photomultiplier tube (PSPMT). With this basic design of scintigraphy equipment is expected that scintigraphy equipment engineering activity can be carried out. (author)

  6. Bifunctional chelating agent for the design and development of site specific radiopharmaceuticals and biomolecule conjugation strategy

    Science.gov (United States)

    Katti, Kattesh V.; Prabhu, Kandikere R.; Gali, Hariprasad; Pillarsetty, Nagavara Kishore; Volkert, Wynn A.

    2003-10-21

    There is provided a method of labeling a biomolecule with a transition metal or radiometal in a site specific manner to produce a diagnostic or therapeutic pharmaceutical compound by synthesizing a P.sub.2 N.sub.2 -bifunctional chelating agent intermediate, complexing the intermediate with a radio metal or a transition metal, and covalently linking the resulting metal-complexed bifunctional chelating agent with a biomolecule in a site specific manner. Also provided is a method of synthesizing the --PR.sub.2 containing biomolecules by synthesizing a P.sub.2 N.sub.2 -bifunctional chelating agent intermediate, complexing the intermediate with a radiometal or a transition metal, and covalently linking the resulting radio metal-complexed bifunctional chelating agent with a biomolecule in a site specific manner. There is provided a therapeutic or diagnostic agent comprising a --PR.sub.2 containing biomolecule.

  7. Hot conditioning equipment conceptual design report

    Energy Technology Data Exchange (ETDEWEB)

    Bradshaw, F.W., Westinghouse Hanford

    1996-08-06

    This report documents the conceptual design of the Hot Conditioning System Equipment. The Hot conditioning System will consist of two separate designs: the Hot Conditioning System Equipment; and the Hot Conditioning System Annex. The Hot Conditioning System Equipment Design includes the equipment such as ovens, vacuum pumps, inert gas delivery systems, etc.necessary to condition spent nuclear fuel currently in storage in the K Basins of the Hanford Site. The Hot Conditioning System Annex consists of the facility of house the Hot Conditioning System. The Hot Conditioning System will be housed in an annex to the Canister Storage Building. The Hot Conditioning System will consist of pits in the floor which contain ovens in which the spent nuclear will be conditioned prior to interim storage.

  8. Hot conditioning equipment conceptual design report

    International Nuclear Information System (INIS)

    This report documents the conceptual design of the Hot Conditioning System Equipment. The Hot conditioning System will consist of two separate designs: the Hot Conditioning System Equipment; and the Hot Conditioning System Annex. The Hot Conditioning System Equipment Design includes the equipment such as ovens, vacuum pumps, inert gas delivery systems, etc.necessary to condition spent nuclear fuel currently in storage in the K Basins of the Hanford Site. The Hot Conditioning System Annex consists of the facility of house the Hot Conditioning System. The Hot Conditioning System will be housed in an annex to the Canister Storage Building. The Hot Conditioning System will consist of pits in the floor which contain ovens in which the spent nuclear will be conditioned prior to interim storage

  9. Optimization of biomolecule separation by combining microscale filtration and design-of-experiment methods.

    Science.gov (United States)

    Kazemi, Amir S; Kawka, Karina; Latulippe, David R

    2016-10-01

    There is considerable interest in developing microscale (i.e., high-throughput) methods that enable multiple filtration experiments to be run in parallel with smaller sample amounts and thus reduce the overall required time and associated cost to run the filtration tests. Previous studies to date have focused on simply evaluating the filtration capacity, not the separation performance. In this work, the stirred-well filtration (SWF) method was used in combination with design-of-experiment (DOE) methods to optimize the separation performance for three binary mixtures of bio-molecules: protein-protein, protein-polysaccharide, and protein-DNA. Using the parallel based format of the SWF method, eight constant-flux ultrafiltration experiments were conducted at once to study the effects of stirring conditions, permeate flux, and/or solution conditions (pH, ionic strength). Four separate filtration tests were conducted for each combination of process variables; in total, over 100 separate tests were conducted. The sieving coefficient and selectivity results are presented to match the DOE design format and enable a greater understanding of the effects of the different process variables that were studied. The method described herein can be used to rapidly determine the optimal combination of process factors that give the best separation performance for a range of membrane-based separations applications and thus obviate the need to run a large number of traditional lab-scale tests. Biotechnol. Bioeng. 2016;113: 2131-2139. © 2016 Wiley Periodicals, Inc. PMID:27563852

  10. Improving the hygienic design of closed equipment

    DEFF Research Database (Denmark)

    Friis, Alan; Jensen, Bo Boye Busk

    2005-01-01

    cleaning action of fluid flow and the interaction between flow characteristics and soil attached to surfaces. Ideally, such information can be contained in fluid dynamics models or rules of thumb which can be used to assist in design of process equipment and when optimising cleaning procedures. Extending...... process plant. In turn the adhesion mechanisms between the soil and the surface of the process equipment must be overcome. In closed processes validation proves rather difficult, as inspection often is not possible. Hence, we benefit from a greater basic understanding of the influence of the mechanical...

  11. ITER L 7 duct remote handling equipment design report

    International Nuclear Information System (INIS)

    The operation, design and interfaces of the 'Duct Vehicle' and it's associated remote handling equipment are briefly described in this document. This equipment is being designed by Spar Aerospace Ltd. for the Divertor Test Platform as part of ITER Research and Development Project L-7. Canadian Fusion Fuels Technology Project funds this work as part of the Canadian Contribution to ITER. This document describes the equipment design status at the September 1996 design review. 23 figs

  12. Design report for cask transportation equipment

    International Nuclear Information System (INIS)

    In Korea, the spent fuels stored in the spent fuel storage pools in the domestic nuclear power plants significantly affects the continuation of the power plant operation. To solve this problem, KAERI has developed KSC-4 spent fuel shipping cask, which can transport 4 PWR spent fuel assemblies. Besides the development of the cask, KAERI developed transportation equipment which needed to use of KSC-4 cask. These equipment consist of cask handling tools such as lifting yoke, lid handling tool and spent fuel handling tool, etc. and transportation equipment such as trailer. In this report the usages, structures and functions of these tools and equipment were described, and the safety evaluation was carried out for each equipment

  13. Towards structured integration of maintenance knowledge in industrial equipment design

    OpenAIRE

    Mulder, W; Basten, R.J.I.; Jauregui Becker, J.M.; Dongen, van, C.J.J.; Lindemann, Udo; Venkataraman, Srinivasan; Kim, Yong Se

    2013-01-01

    Industrial equipment requires maintenance to remain operational. The level of maintenance that is required, and how easily it can be executed, is affected by the characteristics of the equipment. Therefore, design decisions have a strong influence on the effectiveness and efficiency of the maintenance process. Ideally, the design of the equipment should be aligned with the design of the maintenance service. Relevant knowledge about the relationships between them is available in both the liter...

  14. Conceptual design report, CEBAF basic experimental equipment

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-04-13

    The Continuous Electron Beam Accelerator Facility (CEBAF) will be dedicated to basic research in Nuclear Physics using electrons and photons as projectiles. The accelerator configuration allows three nearly continuous beams to be delivered simultaneously in three experimental halls, which will be equipped with complementary sets of instruments: Hall A--two high resolution magnetic spectrometers; Hall B--a large acceptance magnetic spectrometer; Hall C--a high-momentum, moderate resolution, magnetic spectrometer and a variety of more dedicated instruments. This report contains a short description of the initial complement of experimental equipment to be installed in each of the three halls.

  15. Design and Development of Carborne Survey Equipment

    Directory of Open Access Journals (Sweden)

    Syarbaini

    2015-08-01

    Full Text Available In most nuclear and radiological emergencies involving the release of radioactive materials to environment, it is important that data on the geographic distribution of potentially hazardous radioactive materials be quickly presented to the authorities. The mobile radiation detection system makes it possible to measure radioactive materials in the environment at random places because of its easy mobility from place to place. The purpose of the work is to develop a mobile radiation detection system to measure gamma exposure rate, radioactive material on the ground and airborne radioactive particulate in the environment quickly. In this work, we have developed a carborne survey equipment system consisting of three gamma ray detectors, one airbome radioactive particulate sampler, a GPS (Global Positioning System, meteorological sensors, a data acquisition system and an operation software. Performance of the carborne survey equipment has been successfully demonstrated to measure iodine and argon release from medical isotope production facility on Serpong in western Java, Indonesia.

  16. Design and Adaptation of EMF Equipment

    OpenAIRE

    Beerwald, C.; Beerwald, M.; Henselek, A.

    2004-01-01

    Since the electromagnetic forming (EMF) becomes more and more accepted within industrial manufacturing, the methods engineer has to deal with the choice of matching equipment as to perform the task of production in the best possible way. At the present time several manufacturers offer EMF-machines with different characteristics, whereby the machines consist of a pulse power generator and an exchangeable tool coil. The storable energy, the current capability and a high short circuit frequen...

  17. Recent advancements in nanotechnological strategies in selection, design and delivery of biomolecules for skin regeneration.

    Science.gov (United States)

    Korrapati, Purna Sai; Karthikeyan, K; Satish, Aishwarya; Krishnaswamy, Venkat Raghavan; Venugopal, Jayarama Reddy; Ramakrishna, Seeram

    2016-10-01

    Skin is a very complex organ and hence designing a bioengineered skin model replicating the essential physiological characteristics for replacing the diseased or damaged parts has been a challenging goal for many. Newer technologies for satisfying most of the criteria are being attempted with the copious efforts of biologists, engineers, physiologists, using multitude of features in combination. Amongst them nanotechnology based biomaterials have gained prominence owing to the enhanced pharmacokinetics, bio-distribution profile, extended half-life and reduced side effects. Designing a matrix that can be assimilated into the body during the regeneration and delivering the essential pharmacological agents in a temporal and spatially specific manner is a tremendous goal. This review essentially deals with the various approaches for designing a multidisciplinary translational smart matrix for addressing the various skin related ailments. PMID:27287175

  18. Maintainability design criteria for packaging of spacecraft replaceable electronic equipment.

    Science.gov (United States)

    Kappler, J. R.; Folsom, A. B.

    1972-01-01

    Maintainability must be designed into long-duration spacecraft and equipment to provide the required high probability of mission success with the least cost and weight. The ability to perform repairs quickly and easily in a space environment can be achieved by imposing specific maintainability design criteria on spacecraft equipment design and installation. A study was funded to investigate and define design criteria for electronic equipment that would permit rapid removal and replacement in a space environment. The results of the study are discussed together with subsequent simulated zero-g demonstration tests of a mockup with new concepts for packaging.

  19. Design and materials for power generation equipments. 4. Design and materials of steam turbine equipment

    International Nuclear Information System (INIS)

    As development on technology of the steam turbine equipments (STEs) can be characterized at upgrading of temperature, pressure, and efficiency of steam conditions, improvement and development of materials and device of structure and design are also promoted so as to accommodate to them. The STEs can be roughly divided to for thermal power generation, for nuclear power generation, for geothermal power generation, and so on, on a base of kinds of steam generation sources, but can be divided to for industry with relatively middle and small capacity and for business use mainly with large capacity. Here was summarized concepts, especially considerations at design on selecting materials, on design of steam turbine, main steam valve, and heat exchanger on STEs for thermal and nuclear power generations for business uses. And, on the steam turbine, together with summarizing rotors, casings, blades (rotating and stationary blades), clamping bolts, and bearings, they were introduced under separation for thermal power generation from for nuclear power generation, because of large difference between their using conditions, and so on. (G.K.)

  20. Equipment design guidance document for flammable gas waste storage tank new equipment

    International Nuclear Information System (INIS)

    This document is intended to be used as guidance for design engineers who are involved in design of new equipment slated for use in Flammable Gas Waste Storage Tanks. The purpose of this document is to provide design guidance for all new equipment intended for application into those Hanford storage tanks in which flammable gas controls are required to be addressed as part of the equipment design. These design criteria are to be used as guidance. The design of each specific piece of new equipment shall be required, as a minimum to be reviewed by qualified Unreviewed Safety Question evaluators as an integral part of the final design approval. Further Safety Assessment may be also needed. This guidance is intended to be used in conjunction with the Operating Specifications Documents (OSDs) established for defining work controls in the waste storage tanks. The criteria set forth should be reviewed for applicability if the equipment will be required to operate in locations containing unacceptable concentrations of flammable gas

  1. Cost effective radiotherapy equipment design to overcome budget shortfalls

    International Nuclear Information System (INIS)

    Medical physicists cannot always depend on manufacturers for gadgets required for dosimetry, radiotherapy treatments, and for teaching purposes. The immediate need, budget constraints, specifications of the devices makes it necessary for medical physicists to try and design equipment when required. Many valuable ideas for new equipment in radiotherapy come from medical physicists

  2. Towards structured integration of maintenance knowledge in industrial equipment design

    NARCIS (Netherlands)

    Mulder, W.; Basten, R.J.I.; Jauregui Becker, J.M.; Dongen, van L.A.M.; Lindemann, Udo; Venkataraman, Srinivasan; Kim, Yong Se

    2013-01-01

    Industrial equipment requires maintenance to remain operational. The level of maintenance that is required, and how easily it can be executed, is affected by the characteristics of the equipment. Therefore, design decisions have a strong influence on the effectiveness and efficiency of the maintenan

  3. Standard guide for general design considerations for hot cell equipment

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2008-01-01

    1.1 Intent: 1.1.1 The intent of this guide is to provide general design and operating considerations for the safe and dependable operation of remotely operated hot cell equipment. Hot cell equipment is hardware used to handle, process, or analyze nuclear or radioactive material in a shielded room. The equipment is placed behind radiation shield walls and cannot be directly accessed by the operators or by maintenance personnel because of the radiation exposure hazards. Therefore, the equipment is operated remotely, either with or without the aid of viewing. 1.1.2 This guide may apply to equipment in other radioactive remotely operated facilities such as suited entry repair areas, canyons or caves, but does not apply to equipment used in commercial power reactors. 1.1.3 This guide does not apply to equipment used in gloveboxes. 1.2 Applicability: 1.2.1 This guide is intended for persons who are tasked with the planning, design, procurement, fabrication, installation, or testing of equipment used in rem...

  4. Engineering design guidelines for electromagnetic pulse hardening of naval equipment

    Science.gov (United States)

    Rogers, S. R.; Perala, R. A.; Rosich, R. K.; Cook, R. B.; Rudolph, T. H.

    1981-07-01

    This document is intended to be used by engineers who design and manufacture shipboard equipment. It is complete in the sense that both the EMP hazard and the means of mitigating the hazard (hardening) are presented. The hazard is described, which not only discusses EMP generation in a general sense, but it also presents specific threat levels for EMP fields and transient currents and voltages included on cables and antennas which are connected to electronic equipment. This specific threat constitutes an EMP survivability criteria which must be met by the mission critical equipment. The necessary hardening technology areas include volume shielding, cable shielding and connectors, interface susceptibility analysis, terminal protective devices, upset and upset hardening, common mode rejection techniques, optical isolation, and grounding/bonding techniques. Test techniques which can verify equipment hardness are presented along with methods to observe the equipment's hardness and maintain the hardness.

  5. Reliable design of electronic equipment an engineering guide

    CERN Document Server

    Natarajan, Dhanasekharan

    2014-01-01

    This book explains reliability techniques with examples from electronics design for the benefit of engineers. It presents the application of de-rating, FMEA, overstress analyses and reliability improvement tests for designing reliable electronic equipment. Adequate information is provided for designing computerized reliability database system to support the application of the techniques by designers. Pedantic terms and the associated mathematics of reliability engineering discipline are excluded for the benefit of comprehensiveness and practical applications. This book offers excellent support

  6. Design review report for modifications to RMCS safety class equipment

    International Nuclear Information System (INIS)

    This report documents the completion of the formal design review for modifications to the Rotary Mode Core Sampling (RMCS) safety class equipment. These modifications are intended to support core sampling operations in waste tanks requiring flammable gas controls. The objective of this review was to approve the Engineering Change Notices affecting safety class equipment used in the RMCS system. The conclusion reached by the review committee was that these changes are acceptable

  7. Design review report for modifications to RMCS safety class equipment

    Energy Technology Data Exchange (ETDEWEB)

    Corbett, J.E.

    1997-05-30

    This report documents the completion of the formal design review for modifications to the Rotary Mode Core Sampling (RMCS) safety class equipment. These modifications are intended to support core sampling operations in waste tanks requiring flammable gas controls. The objective of this review was to approve the Engineering Change Notices affecting safety class equipment used in the RMCS system. The conclusion reached by the review committee was that these changes are acceptable.

  8. Design of equipment management information system for nuclear power plant

    International Nuclear Information System (INIS)

    The author describes the ideas and practical method for need analysis, system function dividing, code design, program design and network disposition of equipment purchase management system of nuclear power plant during building, from the view of engineering investment control, schedule control and quality control

  9. System design description for master equipment list, phase I

    International Nuclear Information System (INIS)

    This System Design Description (SDD) is for the Master Equipment List Phase I (MEL). It has been prepared following the WI-IC-CM-3-10, ''Software Practices,'' (Ref. 6). This SDD describes the internal design for implementation of the MEL Phase I

  10. Verification of the thermal design of electronic equipment

    Energy Technology Data Exchange (ETDEWEB)

    Hienonen, R.; Karjalainen, M.; Lankinen, R. [VTT Automation, Espoo (Finland). ProTechno

    1997-12-31

    The project `Verification of the thermal design of electronic equipment` studied the methodology to be followed in the verification of thermal design of electronic equipment. This project forms part of the `Cool Electronics` research programme funded by TEKES, the Finnish Technology Development Centre. This project was carried out jointly by VTT Automation, Lappeenranta University of Technology, Nokia Research Center and ABB Industry Oy VSD-Technology. The thermal design of electronic equipment has a significant impact on the cost, reliability, tolerance to different environments, selection of components and materials, and ergonomics of the product. This report describes the method for verification of thermal design. It assesses the goals set for thermal design, environmental requirements, technical implementation of the design, thermal simulation and modelling, and design qualification testing and the measurements needed. The verification method covers all packaging levels of electronic equipment from the system level to the electronic component level. The method described in this report can be used as part of the quality system of a corporation. The report includes information about the measurement and test methods needed in the verification process. Some measurement methods for the temperature, flow and pressure of air are described. (orig.) Published in Finnish VTT Julkaisuja 824. 22 refs.

  11. Engineering electrodynamics electric machine, transformer, and power equipment design

    CERN Document Server

    Turowski, Janusz

    2013-01-01

    Due to a huge concentration of electromagnetic fields and eddy currents, large power equipment and systems are prone to crushing forces, overheating, and overloading. Luckily, power failures due to disturbances like these can be predicted and/or prevented.Based on the success of internationally acclaimed computer programs, such as the authors' own RNM-3D, Engineering Electrodynamics: Electric Machine, Transformer, and Power Equipment Design explains how to implement industry-proven modeling and design techniques to solve complex electromagnetic phenomena. Considering recent progress in magneti

  12. Maintenance approach and remote equipment design for FER

    International Nuclear Information System (INIS)

    The latest FER remote maintenance concept and various remote equipments design are described. Reactor concept of the FER is decided based primarily on tradeoffs between reliability of maintenance scheme and minimization of capital costs. Key features of the FER structure are: 1) the most reliable maintenance procedure, 2) optimization of PF coil allocation, 3) installation of sacrificed ''guard limiter'' on the inboard first wall area against off-normal conditions, and 4) reliable and simple shielding structure (water-tank type shield). Local guard limiters are designed to be easily replaceable without breaking a plasma vacuum. Outboard shield and divertor modules are planned to be removed by horizontal access with reliable single straight-line motion. Transfer casks are prepared for the containment of tritium and activated debris during transportation. As for equipments, design study puts emphasis upon the ''inboard/outboard limiter handling equipments'', ''transfer cask for tritium/radioactive debris'', and ''in-vessel manipulator system for inspection''. This paper consists of general description of the FER, design philosophy, design conditions, maintenance procedure, remote handling equipments, repair facility, and urgent R and D issues/JAERI's R and D programme for remote handling. (author). 7 refs, 6 figs, 3 tabs

  13. Design of integrated emergency receiver equipment for radioactive scrap resin

    International Nuclear Information System (INIS)

    Based on the source item features and considering the requirement of safety, light-weight and interface support in radioactive scrap resin emergency receiver for PWR coolant circuit, the receiving process flow is proposed. The integrated receiving equipment is designed, and its corresponding experiment method and requirement is brought forward. (authors)

  14. Equipment design for reliability testing of protection system

    International Nuclear Information System (INIS)

    The equipment for reliability testing of cable of protection system has been designed as a a furnace with the electric heater have a 4 kW power, and need time 10 minute to reach the designed maximum temperature 3000C. The dimension of furnace is 800 mm diameter and 2000 mm length is isolated use rockwool isolator and coated by aluminium. For the designed maximum temperature the surface temperature is 78 0c. Assemble of specimens is arranged horizontally in the furnace. The failure criteria will be defined based on the behaviour of the load circuit in each line of cable specimens

  15. The stem cell laboratory: design, equipment, and oversight.

    Science.gov (United States)

    Wesselschmidt, Robin L; Schwartz, Philip H

    2011-01-01

    This chapter describes some of the major issues to be considered when setting up a laboratory for the culture of human pluripotent stem cells (hPSCs). The process of establishing a hPSC laboratory can be divided into two equally important parts. One is completely administrative and includes developing protocols, seeking approval, and establishing reporting processes and documentation. The other part of establishing a hPSC laboratory involves the physical plant and includes design, equipment and personnel. Proper planning of laboratory operations and proper design of the physical layout of the stem cell laboratory so that meets the scope of planned operations is a major undertaking, but the time spent upfront will pay long-term returns in operational efficiency and effectiveness. A well-planned, organized, and properly equipped laboratory supports research activities by increasing efficiency and reducing lost time and wasted resources. PMID:21822863

  16. The Design of Administrative System Based On Portable Intellectual Equipment

    Institute of Scientific and Technical Information of China (English)

    Zeng,Jianhua; Chen,Haisong; Feng,Mingfa; Liang,Zhaofeng

    2005-01-01

    Regard property management of intelligentized residential area as the application background, we introduce a kind of method for the design of a management system based on portable intelligent equipments. The system is made up of intelligent terminals and personal computers. The intelligent terminals are for data collection and data storage. They communicate with personal computers through high-speed interface. The personal computers communicate with intelligent devices and carry out data analysis and data processing with VB6.0.

  17. Design of EPON far-end equipment based on FTTH

    Science.gov (United States)

    Feng, Xiancheng; Yun, Xiang

    2008-12-01

    Now, most favors fiber access is mainly the EPON fiber access system. Inheriting from the low cost of Ethernet, usability and bandwidth of optical network, EPON technology is one of the best technologies in fiber access and is adopted by the carriers all over the world widely. According to the scheme analysis to FTTH fan-end equipment, hardware design of ONU is proposed in this paper. The FTTH far-end equipment software design deference modulation design concept, it divides the software designment into 5 function modules: the module of low-layer driver, the module of system management, the module of master/slave communication, and the module of main/Standby switch and the module of command line. The software flow of the host computer is also analyzed. Finally, test is made for Ethernet service performance of FTTH far-end equipment, E1 service performance and the optical path protection switching, and so on. The results of test indicates that all the items are accordance with technical request of far-end ONU equipment and possess good quality and fully reach the requirement of telecommunication level equipment. The far-end equipment of FTTH divides into several parts based on the function: the control module, the exchange module, the UNI interface module, the ONU module, the EPON interface module, the network management debugging module, the voice processing module, the circuit simulation module, the CATV module. In the downstream direction, under the protect condition, we design 2 optical modules. The system can set one group optical module working and another group optical module closure when it is initialized. When the optical fiber line is cut off, the LOS warning comes out. It will cause MUX to replace another group optical module, simultaneously will reset module 3701/3711 and will make it again test the distance, and will give the plug board MPC850 report through the GPIO port. During normal mode, the downstream optical signal is transformed into the

  18. IRIS safety system and equipment design verification test plan

    International Nuclear Information System (INIS)

    The International Reactor Innovative and Secure (IRIS) is an advanced, integral, light-water cooled reactor of medium generating capacity (335 MWe), geared at near term deployment (2012-2015). IRIS is an innovative design that features an integral reactor vessel that contains all the reactor coolant system components, including the steam generators, coolant pumps, pressurizer and heaters, and control rod drive mechanisms; in addition to the: typical core, internals, control rods and neutron reflector. Other IRIS innovations also include a small, high design pressure, spherical steel containment; and a simplified passive safety system concept and equipment features that derive from its unique 'safety-by-design' IM philosophy. The IRIS ('safety-by-design')TM approach not only improves safety, but it also reduces the overall cost by allowing a significant reduction and simplification in safety systems. Moreover, IRIS improved safety supports licensing the power plant without the need for off-site emergency response planning an objective which is part of the pre-application with NRC and is also is being pursued in collaboration with IAEA. The IRIS innovative integral reactor coolant system design, as well as its innovative ('safety-by-design')TM approach features, has resulted in the need for new safety analyses and new equipment design and qualification, in order to successfully license the plant. Therefore, the IRIS design team has developed a test plan that will provide the necessary data for safety analyses verification as well as the demonstration of equipment manufacturing feasibility and operation. This paper will present the 'IRIS Safety System and Equipment Design Verification Test Plan' which develops and confirms the operation of all the IRIS unique features, and includes component manufacturing feasibility tests, component separate effects tests, component qualification tests, and integral effects tests. These tests will also provide the data necessary to

  19. Designing equipment for use in gamma radiation environments

    International Nuclear Information System (INIS)

    High levels of gamma radiation are known to cause degradation in a variety of materials and components. When designing systems to operate in a high radiation environment, special precautions and procedures should be followed. This report (1) outlines steps that should be followed in designing equipment and (2) explains the general effects of radiation on various engineering materials and components. Much information exists in the literature on radiation effects upon materials. However, very little information is available to give the designer a step-by-step process for designing systems that will be subject to high levels of gamma radiation, such as those found in a nuclear fuel reprocessing facility. In this report, many radiation effect references are relied upon to aid in the design of components and systems. 11 refs., 4 tabs

  20. Designing Equipment for Use in Gamma Radiation Environments

    Energy Technology Data Exchange (ETDEWEB)

    Vandergriff, K.U.

    1990-01-01

    High levels of gamma radiation are known to cause degradation in a variety of materials and components. When designing systems to operate in a high radiation environment, special precautions and procedures should be followed. This report (1) outlines steps that should be followed in designing equipment and (2) explains the general effects of radiation on various engineering materials and components. Much information exists in the literature on radiation effects upon materials. However, very little information is available to give the designer a step-by-step process for designing systems that will be subject to high levels of gamma radiation, such as those found in a nuclear fuel reprocessing facility. In this report, many radiation effect references are relied upon to aid in the design of components and systems.

  1. Conference on Manned Systems Design : New Methods and Equipment

    CERN Document Server

    Kraiss, K-F

    1981-01-01

    This volume contains the proceedings of a conference held in Freiburg, West Germany, September 22-25, 1980, entitled "Manned Systems Design, New Methods and Equipment". The conference was sponsored by the Special Programme Panel on Human Factors of the Scientific Affairs Division of NATO, and supported by Panel VIII, AC/243, on "Human and Biomedical Sciences". Their sponsorship and support are gratefully acknowledged. The contributions in the book are grouped according to the main themes of the conference with special emphasis on analytical approaches, measurement of performance, and simulator design and evaluat ion. The design of manned systems covers many and highly diversified areas. Therefore, a conference under the general title of "Manned Systems Design" is rather ambitious in itself. However, scientists and engineers engaged in the design of manned systems very often are confronted with problems that can be solved only by having several disciplines working together. So it was felt that knowledge about ...

  2. NATO ARI on Ergonomic Data for Equipment Design

    CERN Document Server

    1984-01-01

    For many years ergonomists and human engineering specialists have made significant contributions to the solution of problems faced in the area of human labour and to the introduction of their research results and field experience into the process of equipment design. However, the rapid increase in complexity of equipment in use as well as in development demonstrates the necessity of broaden­ ing the point of view continuously. The workshop held in Munich from March 22nd to March 26th, 1982, was an excellent opportunity for the participants to discuss their respective interests and their interpretation of needs for future research. The workshop was sponsored by the Human Factors Special Programme Panel of the Scientific Affairs Division of NATO. This sponsorship, together with the helpful assistance rendered by Drs. Bayraktar, Kroemer, and Sanders, is gratefully acknowledged. This volume contains the papers presented during the workshop. All these papers are directly related to the general aim: the ex­ chang...

  3. Biomolecules in Astrobiology

    OpenAIRE

    Meringer, Markus

    2013-01-01

    Astrobiology is the study of the origin, distribution and future of life in the universe, biomolecules are molecules produced by living organisms. This talk reviews known facts and open questions about biomolecules in the context of Astrobiology and introduces a research project on "Creating a Reference Set of Amino Acids Structures for Use in Multiple Astrobiology Investigations" that tries to find answers using computational methods.

  4. Design of remote handling equipment for the ITER NBI

    International Nuclear Information System (INIS)

    The ITER machine has three Neutral Beam Injectors (NBIs) placed tangential to the plasma at a minimum radius of 6.25 m. During operation, neutrons produced by the D-T reactions will irradiate the NBI structure and it will become radioactive. Radiation levels will be such that all subsequent maintenance of the NBIs must be carried out remotely. The presence of tritium and possibly radioactive dust requires that precautions be taken during maintenance to prevent the escape of these contaminants beyond the prescribed boundaries. The scope of this task is both the development of remote maintenance procedures and the design of the remote handling equipment to handle the NBIs. This report describes the design of remote handling tools for the ion source and its filaments, transfer cask, maintenance time, manufacturing schedule and cost estimation. (author)

  5. Design of remote handling equipment for the ITER NBI

    Energy Technology Data Exchange (ETDEWEB)

    Oka, Kiyoshi; Tada, Eisuke [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1999-08-01

    The ITER machine has three Neutral Beam Injectors (NBIs) placed tangential to the plasma at a minimum radius of 6.25 m. During operation, neutrons produced by the D-T reactions will irradiate the NBI structure and it will become radioactive. Radiation levels will be such that all subsequent maintenance of the NBIs must be carried out remotely. The presence of tritium and possibly radioactive dust requires that precautions be taken during maintenance to prevent the escape of these contaminants beyond the prescribed boundaries. The scope of this task is both the development of remote maintenance procedures and the design of the remote handling equipment to handle the NBIs. This report describes the design of remote handling tools for the ion source and its filaments, transfer cask, maintenance time, manufacturing schedule and cost estimation. (author)

  6. Design guide for heat transfer equipment in water-cooled nuclear reactor systems

    International Nuclear Information System (INIS)

    Information pertaining to design methods, material selection, fabrication, quality assurance, and performance tests for heat transfer equipment in water-cooled nuclear reactor systems is given in this design guide. This information is intended to assist those concerned with the design, specification, and evaluation of heat transfer equipment for nuclear service and the systems in which this equipment is required. (U.S.)

  7. DNV launches new recommended practice for design of subsea equipment

    Energy Technology Data Exchange (ETDEWEB)

    Toerstad, Elisabeth Heggelund

    2005-07-01

    The application of modern corrosion-resistant alloys to subsea pipelines and components has led to serious problems of hydrogen embrittlement from the corrosion protection system, resulting in cracks and leaks. The most commonly known incidents of this kind are the duplex hubs on Voinhaven, UK and Garn West and the 13% Cr pipelines on Tune and Aasgard, all at the Norwegian shelf. Understanding the nature of this problem has called for a broad multidisciplinary approach, involving expertise on corrosion and metallurgy as well as structural design and integrity. Competence in probabilistic analyses and risk assessments has also been necessary in order to set acceptance criteria and evaluate probability of failure for existing installations. (Det Norske Veritas (DNV) is now about to issues a Recommended Practise (RP) for design of subsea equipment in duplex steels under Cathodic Protection. The RP is based on knowledge gained through failure investigations, qualification pr grams and research work, and a broad industry consortium has contributed with experience and knowledge. Hydrogen Induced Stress Cracking (HISC) due to hydrogen from the Cathodic Protection (CP) system has been one of the most frequent and costly failure modes for subsea equipment and pipelines in the North Sea over the recent years. Today, the international oil business is looking to Norway for assistance in establishing detailed knowledge about and preventive measures against this failure mode. A significant research work is currently being carried out jointly by DNV, SINTEF and TWI (The Welding Institute), supported by a broad industry consortium - aiming at a better understanding of the HISC (Hydrogen Induced Stress Cracking) mechanism and establishment of test methods which reflect the sensitivity to cracking. DNV has also established a Recommended Practice, which will be issued late 2005. It reflects the experience gained from the failure examinations, fitness for purpose evaluations, research

  8. Design and Implementation of Equipment Interactive Electronic Technical Manuals

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Interactive electronic technical manuals (IETMs) can significantly improve the maintenance and logistics of modern weapon equipment. Main functiors and development strategies of IETMs are discussed. As an example, the IETM development of a certain equipment is demonstrated.

  9. DESIGNING FEATURES OF POWER OPTICAL UNITS FOR TECHNOLOGICAL EQUIPMENT

    Directory of Open Access Journals (Sweden)

    M. Y. Afanasiev

    2016-03-01

    Full Text Available This paper considers the question of an optical unit designing for transmitting power laser radiation through an optical fiber. The aim of this work is designing a simple construction unit with minimized reflection losses. The source of radiation in the optical unit described below is an ultraviolet laser with diode pumping. We present the general functioning scheme and designing features for the three main parts: laser beam deflecting system, laser beam dump and optical unit control system. The described laser beam deflection system is composed of a moving flat mirror and a spherical scattering mirror. Comparative analysis of the production technology for such mirrors was carried out, and, as a result, the decision was made to produce both mirrors of 99.99 % pure molybdenum without coating. A moving mirror deflects laser emission from a source through a fiber or deflects it on a spherical mirror and into the laser beam dump, moreover, switching from one position to another occurs almost immediately. It is shown that a scattering mirror is necessary, otherwise, the absorbing surface of the beam dump is being worn out irregularly. The laser beam dump is an open conical cavity, in which the conical element with its spire turned to the emission source is placed. Special microgeometry of the internal surface of the beam dump is suggested for the better absorption effect. An optical unit control system consists of a laser beam deflection system, laser temperature sensor, deflection system solenoid temperature sensor, and deflection mirror position sensor. The signal processing algorithm for signals coming from the sensors to the controller is described. The optical unit will be used in special technological equipment.

  10. Experimental equipment design and testing of the DEOX process

    International Nuclear Information System (INIS)

    Several technologies exist or are under development for treating spent oxide fuels. Foremost among these are aqueous and pyrochemical reprocessing which both involve head-end fuel dissolution step. This dissolution step may potentially be shortened if it is combined with a fuel decladding and size reduction process. Declad and Oxidize (DEOX), an advanced head-end processing concept, is being assessed at Argonne National Laboratory (ANL) to meet these decladding and size reduction needs via the oxidation of UO2 to U3O8. DEOX is intended to remove the spent fuel from its cladding, while avoiding oxidation of the cladding that would contaminate the product. An additional goal is to obtain a product particle size distribution between 45 μm to 4 mm. DEOX begins with uranium oxide (UO2) spent fuel pins. Remote tools are used to cut the fuel into segments. Additional equipment is then employed to heat the segments and exposes them to oxygen. The UO2 oxidizes to U3O8 per the reaction 3UO2 + O2 = U3O8, it undergoes a corresponding volume increase, which pulverizes the fuel. This volume increase may cause the pin cladding to split, allowing fuel to escape. Mechanical sieving can further separate the pulverized fuel and cladding. The fuel may then be treated by either aqueous or pyrochemical methods, and the cladding can be disposed of through existing techniques. The DEOX experiments are planned to be run in the argon portion of the Hot Fuel Examination Facility at ANL. During the design phase, engineers identified 6 major components: 1) the fuel cutter - to chop the fuel pins to the desired length; 2) the fuel container - to hold the chopped fuel pieces during processing; 3) the furnace - to heat the fuel samples; 4) the containment vessel - to seal out argon from the hot cell but expose the fuel samples to a pure oxygen environment; 5) the off gas filter - to capture off-gases; and 6) the gas panel - to regulate air-flow and pressure. All the components of the DEOX

  11. Original equipment manufacturers (OEM) protective coating design basis Accident testing

    International Nuclear Information System (INIS)

    The United States Nuclear Regulatory Commission (USNRC) currently holds the position that 100 percent of design basis accident (DBA) unqualified coating materials located within a pressurised water reactor (PWR) containment will fail (dis-bond) during a DBA (e.g. loss of coolant, main steam line break) and may contribute to the emergency core cooling system (ECCS) sump debris source term. Electrical cabinets, small cranes, electric motors, pipe support components, and other miscellaneous equipment installed within US PWR containments are often coated by the original equipment manufacturers (OEM) using DBA unqualified coating materials (usually a standard shop oil based alkyd system). Little or no documented DBA test data currently exists concerning these OEM coatings. In support of the US industry efforts to resolve Generic Safety Issue 191, EPRI International, PSE Division (EPRI PSE) and the Nuclear Utility Coating Council (NUCC) are jointly conducting research to investigate the actual effect of PWR DBA environmental exposure on OEM coatings applied to components installed in US PWR containments. This paper will present details concerning the study. The EPRI/NUCC study, entitled, 'Unqualified OEM Coatings Testing', will be conducted during 2004 in four major steps: 1. conduct an industry-wide survey to determine which components in US PWR containments are normally coated with DBA-unqualified OEM coatings; 2. determine which of the components identified in Step 1 have been previously EQ tested, and review available EQ test data to determine the performance of the OEM coatings when exposed to DBA environments; 3. determine which of the components identified in Step 1 have not been previously EQ tested, and perform DBA testing on samples cut from actual OEM components in accordance with ASTM D3911-03 and ASTM D4082-02; and 4. publish the results of Steps 2 and 3 in two separate reports. The EPRI/NUCC study plan is described in this paper. Since the actual study will

  12. Synchronous and Sequential Strategies in the Process Design of Cascade Equipment

    NARCIS (Netherlands)

    Groot Wassink, Jan; Rácz, Imre G.

    1976-01-01

    Cascade or multistage equipment is characterized by the repetition of similar equipment elements in series. Process design, resulting into the main geometric and kinematic dimensions of the equipment, makes use of different strategies. These strategies, based on a process description, the (equality-

  13. Design of equipment used for high-level waste vitrification at the West Valley Demonstration Project

    International Nuclear Information System (INIS)

    The equipment as designed, started, and operated for high-level radioactive waste vitrification at the West Valley Demonstration Project in western New York State is described. Equipment for the processes of melter feed make-up, vitrification, canister handling, and off-gas treatment are included. For each item of equipment the functional requirements, process description, and hardware descriptions are presented

  14. Design, installation and equipment of a burnable poisons plant

    International Nuclear Information System (INIS)

    The construction of a facility to press and sinter burnable poisons has been decided in order to produce UO2-Gd fuel elements. The paper describes the concept of the project and the construction tasks. Special equipment, such as glove-boxes and sintering furnaces are also described

  15. Design and construction rules for electrical equipments of nuclear islands. 3. ed.

    International Nuclear Information System (INIS)

    The French design and construction for electrical equipments of nuclear islands (RCC-E) deals with equipments of which the failure may have consequences on the safety of persons or appreciable effects on the availability of the power plant. This book presents the rules concerning (1) qualification procedure, (2) the design of functional units, (3) the installation (environmental conditions, protection rules), (4) the constituent elements of equipments, (5) the control and testing methods

  16. Design and construction rules for electrical equipments of nuclear islands: RCC-E. (2 ed.).

    International Nuclear Information System (INIS)

    The RCC-E (French Design and Construction Rules for Electrical equipments of nuclear units) deals with equipments of which the failure may have consequences on the safety of persons or appreciable effects on the availability of the power plant. This book presents the rules concerning 1) the qualification procedure, 2) the design of functional units, 3) the installation (environmental conditions, protection rules), 4) the constituent elements of equipments, 5) the control and testing methods

  17. 46 CFR 130.220 - Design of equipment for cooking and heating.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Design of equipment for cooking and heating. 130.220... Design of equipment for cooking and heating. (a) Doors on each cooking appliance must be provided with heavy-duty hinges and locking-devices to prevent accidental opening in heavy weather. (b) Each...

  18. New design of the forming equipment DRECE for obtaining UFG structure in strip of sheet

    OpenAIRE

    J. Kedron; T. Donic; L. Cizek; Dutkiewicz, J.; K. Malanik; S. Rusz; S. Tylsar

    2010-01-01

    Purpose: of this paper is realisation of engineering design and manufacture of new type of equipment DRECE (Dual Rolling Equal Channel Extrusion), designated for obtaining UFG structure in strip of sheet.Design/methodology/approach: The equipment enables refinement of grain in strip of sheet by extrusion technology without change of cross-section. Special attention is paid to the design of the forming tool in order to prevent upsetting of sheet or its undulation during the forming process.Fin...

  19. Nonlinear excitations in biomolecules

    International Nuclear Information System (INIS)

    The aim of the workshop entitled ''Nonlinear Excitations in Biomolecules'' is to attempt to bridge the gap between the physicists and biologists communities which is mainly due to language and cultural barriers. The progress of nonlinear science in the last few decades which have shown that the combination of nonlinearity, which characterize most biological phenomena, and cooperative effects in a system having a large number of degrees of freedom, can give rise to coherent excitations with remarkable properties. New concepts, such as solitons nd nonlinear energy localisation have become familiar to physicists and applied mathematicians. It is thus tempting to make an analogy between these coherent excitations and the exceptional stability of some biological processes, such as for instance DNA transcription, which require the coordination of many events in the ever changing environment of a cell. Physicists are now invoking nonlinear excitations to describe and explain many bio-molecular processes while biologists often doubt that the seemingly infinite variety of phenomena that they are attempting to classify can be reduced to such simple concepts. A large part of the meeting is devoted to tutorial lectures rather than to latest research results. The book provides a pedagogical introduction to the two topics forming the backbone of the meeting: the theory of nonlinear excitations and solitons, and their application in biology; and the structure and function of biomolecules, as well as energy and charge transport in biophysics. In order to emphasize the link between physics and biology, the volume is not divided along these two topics but according to biological subjects. Each chapter starts with a short introduction attempting to help the reader to find his way among the contributions and point out the connection between them. 23 lectures over the 32 presented have been selected and refers to quantum properties of macro-molecules. (J.S.)

  20. Design of large-scale pressurizer in comprehensive experiment device for nuclear power equipment

    International Nuclear Information System (INIS)

    The author briefly introduces the design of the large-scale pressurizer for the comprehensive experiment device of the nuclear power equipment. This equipment has the following main features: reasonable selection of the material, the fine seal and the ability to prevent the fatigue damage and the thermal shock. This equipment can be supplied for the hot test for the safety valve and the relief valve of all levels nuclear power device

  1. Manual on Safety Aspects of the Design and Equipment of Hot Laboratories

    International Nuclear Information System (INIS)

    With the development of atomic energy application and research, hot laboratories are now being constructed in a number of countries. The present publication describes and discusses experience in several countries in designing equipment for these laboratories. The safe handling of highly radioactive substances is the main purpose of hot laboratory design and equipment. The manual aims at helping those persons, particularly in the developing countries, who plan to design and construct a new hot laboratory or modify an existing one. It does not deal in great detail with the engineering design of protective and handling equipment; these matters can be found in the comprehensive list of references. The manual itself covers only basic ideas and different approaches in the design of laboratory building, hot cells, shielded and glove boxes, fume cupboards, and handling and viewing equipment. Systems for transferring materials and main services are also discussed.

  2. Cost effectiveness of operator features in equipment design.

    Science.gov (United States)

    Williams, J C

    1983-06-01

    In design negotiation, the attribution of credible values to the incorporation or deletion of operator features allows engineers the freedom to judge the overall effect of human factors recommendations in relation to the achievement of a design specification. Likewise in the development phase, product planners frequently need more precise statements about productivity, training needs and general operational performance than, "it will be greater/less, worse/better than...". The method described utilises measured and synthetic data, learning theory and Markov processes to calculate the likelihood of operator task failure. These failure rates are then treated via filter factors derived from the application of the Nominal Groups Technique to give a global statement of the likelihood of operator failure resulting in unscheduled calls for service. Using the relationship between the cost of service calls and the overall life cost of developing, manufacturing, marketing and supporting a leased product, it is then possible to place credible values on the design features in question. Thus during the design process it becomes feasible to calculate the likely effects of human factors recommendations and modifications in relation to manufacturing costs, and thereby facilitate rational assessment of their implementation on a sound economic basis. This technique has been used to considerable effect, and represents a useful additional tool for the human factors practitioner in the design negotiation process. Further developments and refinements are planned, and it is anticipated that a similar technique will shortly be available to enable assessment of the effectiveness of product training programmes and job aids. PMID:15676470

  3. The optimization design of nuclear measurement teaching equipment

    International Nuclear Information System (INIS)

    So far domestic student-oriented experimental nuclear measuring instruments are used only to measure object density, thickness or material level, and in the choice of sources activity is mostly about 10 mCi. this design will proposed a optimization program dealing with domestic situation. It discussed the radioactive sources activity, the structural design of sealed sources, such as the choice of the tested material in order to get a program optimization. The program used 1 mCi activity radioactive sources 137Cs to reduce the radiation dose, and the measurement function was improved. So that the apparatus can measure density, thickness nad material level. (authors)

  4. Seismic Analysis of Nuclear Power Equipment Related to Design

    International Nuclear Information System (INIS)

    We use the finite element method to analyze the seismic design of a liquid storage tank for a polar crane at a nuclear power plant. We obtained the natural frequency and vibration modes by modal analysis, and we evaluated the seismic stability by response spectrum analysis. Furthermore, the seismic analysis of the tank was accomplished by analyzing not only the forces applied to the wall by the sloshing of the liquid, but also the safe-shutdown earthquake condition for the tank. We propose a seismic-design process and a seismic-analysis method for liquid storage tanks based on the commercial finite element analysis program, ANSYS

  5. Design of highwall mining equipment electronic guidance package

    Energy Technology Data Exchange (ETDEWEB)

    Brenden, B.B.; Morgen, G.P.; Shorpik, J.R.; Farrar, R.

    1981-11-01

    This report provides design specifics and guidance software for a guidance system intended for use in guiding an auger type highwall mining head through thin coal seams to depths of up to 600 ft. A small desk top computer is used at the operator's station to send and receive signals in serialized bit streams to a downhole microprocessor. The guidance system accepts signals from a variety of sensors and uses these signals to plot and control the course of the auger head automatically using computer algorithms designed to keep the auger head in the coal seam and maintain a specified stump thickness.

  6. Automation of finite element analysis in pressure equipments design. Applications in energy and petrochemistry industries

    International Nuclear Information System (INIS)

    Pressure Equipments are used in different Petrochemistry and Energy industries, like in thermal ou nuclear power plants, oil refineries, and chemical plants. These industries have to insure the safety and environmental conditions. Design of Pressure Equipments have to respect Codes and Standards. For those Pressure Vessels with Neighbouring nozzles, or under load cases different from Pressure loadings (Seismic, Concentrated, etc..), Finite Element simulation remains the unique and accepted method for verifying equipments design according to Codes and Standards. This paper presents application of automated procedure for stress and criteria verification in Energy and Petrochemistry industries. This automated procedure allows to insure the analysis quality and to reduce the analysis time. (author)

  7. Structuring of Information Base for Designing Fire Equipment

    OpenAIRE

    Zinko, Roman

    2015-01-01

    Proper ordering and structuring help process large volumes of knowledge quickly, identify key trends and changes in design, and offer effective solutions of the current issues. Using term by term disjunction allows processing large amounts of knowledge, and representation of the predicate presented as a graph provides a clear visualization. The example of the application of the above-mentioned method while creating a new fire truck to fight forest fires is provided.

  8. Biomolecule labelling by 186 Re

    International Nuclear Information System (INIS)

    The aim of this study is to develop and improve the existing radiolabelling techniques of peptides and monoclonal antibodies with 186 Re and 188 Re as potential agents for cancer targeted radiotherapy. We selected the following methods and techniques for direct labelling of peptides and monoclonal antibody: 1. Prereduction of -S-S- bridges of biomolecule to sulfhydryls using reducing agents: ascorbic acid, cysteine, active hydrogen, 2,3 dimercaptopropanol. The prereduction reactions are controlled by massic ratios of reduction agents/biomolecule, pH, temperature and time of incubation; 2. Reduction of 186 Re O4- stannous chloride in acid and alkaline pH; 3. Coupling reaction of 186 Re (red) with the biomolecule controlled by the time and temperature of incubation, the influence of pH regarding the binding of 186 Re to the biomolecules. The quality control was effected by chromatography techniques (paper and elution gel chromatography) on labeled biomolecule before and after purification. The elution gel chromatography was spectrophotometricaly monitored at 280 nm. In the same time the radioactivity of samples was measured using a gamma counter. All the results confirm in vitro stability of labeled biomolecule. The biological evaluation studies regarding accumulation and biological affinity will be controlled by scintigraphy method. Biodistribution studies will be effected to Walker tumor bearing animals at 4 and 24 hours after injections. (authors)

  9. Sustainable hydrogen - A challenge for materials science and equipment design

    International Nuclear Information System (INIS)

    Full text: Hydrogen is the ideal fuel, considering its fully non-polluting by-products. Still, in discussions on 'sustainable hydrogen', there must be considered all the steps implied in hydrogen production, storage and use and the overall energy balance represents the real starting point of evaluating the sustainability. So far, hydrogen production is related to rather energy-consuming processes; extended research is devoted to develop high efficiency processes, but the industrial hydrogen production makes use of either large electrical or thermal energy amounts. Hydrogen production via water photolysis represents, consequently a viable alternative although many steps have to be elaborated to reached the industrial scale of these processes. Hydrogen storing represents another problem that affects its application; a safe storage way, in metal hydrides, is still under intensive research all over the world. The group of the Centre of Product Design for Sustainable Development is engaged in research for developing a laboratory photolyser, able to produce hydrogen and to offer an efficient storage alternative. The photolyser is a photo-electrochemical cell, and the efficiency of the photolysis process depends on several factors: - the photo-electrodes: thin films of wide band gap semiconductors with tailored properties; - the aqueous environment, with effect on the electrode materials properties and stability; - the external bias; - the cell design. The paper focuses mainly on the photo-electrode materials that were tested. The influence of the composition, crystalline and defect structure, of the morphology and of the interfaces on the photolysis process are reviewed. The effect of the pH in the aqueous media is discussed along with the stability of the materials and the reversibility of the adsorption/desorption processes. The design criteria that must be fulfilled in developing the photolyser are also discussed. (authors)

  10. RCC-E design and construction rules for the electrical equipments of nuclear islands

    International Nuclear Information System (INIS)

    This compilation of design and construction rules concerns the equipments and softwares, the failure of which can have consequences on personnel's safety or significant impacts on the nuclear power plant availability. It is designed to be used in the framework of contractual relations between clients and suppliers. This document does not treat of all electrical equipments with the same level of detail because standard documents are detailed enough in most cases. The rules are organized in six sections dealing with: general dispositions and quality assurance, qualification and agreement, design of equipments (coordination of electrical characteristics, periodical tests and availability, interchangeability of equipments), electrical installations (grounding, protection systems, labelling), components, test and control methods. (J.S.)

  11. Improvements of seismic design of nuclear power plant equipment

    International Nuclear Information System (INIS)

    A brief survey and overview of the current research and development in Japan was presented. Particularly, several kinds of new dampers and isolators were developed and those effectiveness were examined by caring out the large-scale vibration test and so on. The evaluation of the energy absorption of these damping devices at the earthquake appeared to be significant. In addition, it must be necessary to investigate the design margin and the failure mode and limit problem to these devices and the nuclear structures and piping supported by those. Mutual exchange of the information related to these technology and research has to be put forward and cooperative works including the international conference on those issues should be promoted. (J.P.N.)

  12. Improvements of seismic design of nuclear power plant equipment

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Kohei [Tokyo Metropolitan Univ., Hachioji (Japan). Faculty of Technology; Takayama, Yoshihiro

    1997-03-01

    A brief survey and overview of the current research and development in Japan was presented. Particularly, several kinds of new dampers and isolators were developed and those effectiveness were examined by caring out the large-scale vibration test and so on. The evaluation of the energy absorption of these damping devices at the earthquake appeared to be significant. In addition, it must be necessary to investigate the design margin and the failure mode and limit problem to these devices and the nuclear structures and piping supported by those. Mutual exchange of the information related to these technology and research has to be put forward and cooperative works including the international conference on those issues should be promoted. (J.P.N.)

  13. Design and Development of Decision Support System for Equipping Farm Machines

    Directory of Open Access Journals (Sweden)

    Ying Wang

    2014-06-01

    Full Text Available Equipping farm machines is the key link of agricultural production process. The decision support system of equipping farm machines is able to aid managers to make scientific and effective decision. In this paper, the decision support system of equipping farm machines is designed and developed based on the related theories and the thought of prototype. The system chooses Delphi 7.0 as development language, and uses three classic equipping methods to establish system models. For the complex linear programming model, firstly it is established by M-file of Matlab, then COM components are generated; finally Delphi calls the COM components to solve. The database of the system is established and managed by SQL Server 2005. It can be seen from the result of the system application study that the system could assist users to equip farm machines more scientifically and dynamically

  14. Design and ergonomic guidelines for underground mining equipment

    Energy Technology Data Exchange (ETDEWEB)

    Teniswood, C.F.; Mason, L.G.; Clark, D.G.N. (Australian Coal Association, Sydney, NSW (Australia))

    1991-09-01

    Design and ergonomic guidelines for Continuous Miners and Shuttle Cars operating underground in Australian coal mines. These two assessment manuals and their common appendices have been bound as one volume for distribution and use by engineering, safety, management and operation personnel. A worksheet format was adopted wherever possible to encourage staff at the mines to work through procedures and reach identifiable conclusions to problems at the local level. These manuals address the requirements for rating machines and scheduling their modification and rebuilding, together with procedures for evaluating maintainability and repairability. Close attention was given to factors which impact upon the operators of these machines. Worksheets provide for ergonomic assessments of operator compartments, their visual fields and the demands of the workplace upon machine operators. The appendices detail mine surveys, the site modifications already implemented to these machines and suggested changes for future implementation. Reports on the anthropometry of Australian miners and the use of standard and wide angle photographs to assess visual fields. Further aspects of maintainability, repairability and operator related features are covered, and a comprehensive list of references is supplied. Three technology transfer workshops have been held in New South Wales and a seminar introduction to the Queensland industry. Guidelines have been enthusiastically received by participants, who have expressed the desire that other machinery types also be covered.

  15. Human-centered design of the human-system interfaces of medical equipment: thyroid uptake system

    International Nuclear Information System (INIS)

    Technology plays an important role in modern medical centers, making healthcare increasingly complex, relying on complex technical equipment. This technical complexity is particularly noticeable in the nuclear medicine. Poorly design human-system interfaces can increase the risks for human error. The human-centered approach emphasizes the development of the equipment with a deep understanding of the users activities, current work practices, needs and abilities of the users. An important concept of human-centered design is that the ease-of-use of the equipment can be ensured only if users are actively incorporated in all phases of the life cycle of design process. Representative groups of users are exposed to the equipment at various stages in development, in a variety of testing, evaluation and interviewing situations. The users feedback obtained is then used to refine the design, with the result serving as input to the next interaction of design process. The limits of the approach are that the users cannot address any particular future needs without prior experience or knowledge about the equipment operation. The aim of this paper is to present a methodological framework that contributes to the design of the human-system interfaces, through an approach related to the users and their activities. A case study is described in which the methodological framework is being applied in development of new human-system interfaces of the thyroid uptake system. (author)

  16. Human-centered design of the human-system interfaces of medical equipment: thyroid uptake system

    Energy Technology Data Exchange (ETDEWEB)

    Monteiro, Jonathan K.R.; Farias, Marcos S.; Santos, Isaac J.A. Luquetti, E-mail: luquetti@ien.gov.br [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Monteiro, Beany G. [Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ (Brazil). Dept. de Desenho Industrial

    2013-07-01

    Technology plays an important role in modern medical centers, making healthcare increasingly complex, relying on complex technical equipment. This technical complexity is particularly noticeable in the nuclear medicine. Poorly design human-system interfaces can increase the risks for human error. The human-centered approach emphasizes the development of the equipment with a deep understanding of the users activities, current work practices, needs and abilities of the users. An important concept of human-centered design is that the ease-of-use of the equipment can be ensured only if users are actively incorporated in all phases of the life cycle of design process. Representative groups of users are exposed to the equipment at various stages in development, in a variety of testing, evaluation and interviewing situations. The users feedback obtained is then used to refine the design, with the result serving as input to the next interaction of design process. The limits of the approach are that the users cannot address any particular future needs without prior experience or knowledge about the equipment operation. The aim of this paper is to present a methodological framework that contributes to the design of the human-system interfaces, through an approach related to the users and their activities. A case study is described in which the methodological framework is being applied in development of new human-system interfaces of the thyroid uptake system. (author)

  17. Underwater fuel handling equipment maintenance. Verification of design assumptions, specific problems and tools, case study

    International Nuclear Information System (INIS)

    The majority of CANDU Fuel Transfer System equipment at Pickering is located under fourteen feet of water, as dictated by the containment and shielding requirements. Such arrangement, however, creates specific problems with equipment maintenance. Each single piece of equipment serves two generating units, which means in case of defect- double losses on production, or two units shut down simultaneously for planned maintenance. The requirement for underwater maintenance was not anticipated at the design stage, which multiples the level of difficulty, and creates requirement for developing special tools for each work. Removal of the damaged fuel from the receiving bays and decontamination of submerged equipment is also part of the problem. The purpose of this presentation is to share our experience with the designers, operators, maintenance mechanics and technical personnel of the other CANDU generating stations

  18. The design and Manufacturing of the equipment for 'Monju' by Ube Industries, Ltd

    International Nuclear Information System (INIS)

    In the manufacture of the various facilities for the prototype FBR 'Monju', as compared with the case of the experimental FBR 'Joyo', much advanced welding and manufacturing technologies and jigs, tools and equipments for the manufacture have been applied. The main equipments of the various facilities are constructed with stainless steel materials, and the jigs and tools have been exclusively used, besides, the manufacture has been performed in exclusively used clean rooms to prevent the mixing of impurities. As to the welding technology, that for nickel steel and nickel alloy steel, which has many results in chemical plants under high temperature, high pressure and corrosive environment, has been adopted entirely. To the prevention of thermal deformation accompanying welding, attention has been paid most. In the design aspect, finite element analysis was carried out to avoid excessive local stress in the equipment. Ube Industries was in charge of the common maintenance equipment, washing equipment, nuclear fuel washing equipment, and carriages and cranes for the prototype FBR 'Monju'. Those facilities are explained on their main equipments and systems and the design. (K.I.)

  19. Performance based design of structures, systems and equipment in Indian nuclear power plants

    International Nuclear Information System (INIS)

    Nuclear power plants in India have been designed for earthquake resistance by the methods of analysis and testing. Many of the electrical and instrumentation equipment have been tested on shake tables available in India. The performance of the civil structures, piping systems, cable trays, ducting and mechanical, electrical, instrumentation and control equipment in industries around Koyna (1967, 6.5 M), Bhuj (2001, 7.6 M) and Muzaffarabad (2005, 7.6 M) which have witnessed the earthquake is also available

  20. Developing a model to assist in designing ground vehicular electronic equipment for minimum life cycle cost

    OpenAIRE

    Hubbard, Jeffrey Miller

    1991-01-01

    Life cycle cost (LCC) was studied as a design evaluation function for electronic equipment. Sample equipment data were analyzed to discover cost estimating relationships. Using these relationships and basic cost parameters, a LCC model was developed in the BASIC computer language. The model was exercised to produce output for a variety of hypothetical electronic assemblies and operating environments. The resulting LCC estimates were statistically analyzed, leading t...

  1. Design/Operations review of core sampling trucks and associated equipment

    International Nuclear Information System (INIS)

    A systematic review of the design and operations of the core sampling trucks was commissioned by Characterization Equipment Engineering of the Westinghouse Hanford Company in October 1995. The review team reviewed the design documents, specifications, operating procedure, training manuals and safety analysis reports. The review process, findings and corrective actions are summarized in this supporting document

  2. Sustainable Development in Innovation, Design, and Technology Perspective Case Study of Volvo Construction Equipment

    OpenAIRE

    Nithiwat, Riebroicharoen; Koykitcharoen, Pim

    2009-01-01

        Abstract Date: 8 June 2009 Degree Program: International Business and Entrepreneurship Program Division: School of Innovation, Design, and Engineering Course: Graduation Project in Innovation Management Title: Sustainable Development in Innovation, Design, and Technology Perspective.  Case Study of Volvo Construction Equipment Authors: Nithiwat Riebroicharoen 821024-T173 Pim Koykitcharoen 830311-T101 Supervisors: Sten Ekman, Christer Nygre...

  3. Seismic design of equipment and piping systems for nuclear power plants in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Minematsu, Akiyoshi [Tokyo Electric Power Co., Inc. (Japan)

    1997-03-01

    The philosophy of seismic design for nuclear power plant facilities in Japan is based on `Examination Guide for Seismic Design of Nuclear Power Reactor Facilities: Nuclear Power Safety Committee, July 20, 1981` (referred to as `Examination Guide` hereinafter) and the present design criteria have been established based on the survey of governmental improvement and standardization program. The detailed design implementation procedure is further described in `Technical Guidelines for Aseismic Design of Nuclear Power Plants, JEAG4601-1987: Japan Electric Association`. This report describes the principles and design procedure of the seismic design of equipment/piping systems for nuclear power plant in Japan. (J.P.N.)

  4. Seismic design of equipment and piping systems for nuclear power plants in Japan

    International Nuclear Information System (INIS)

    The philosophy of seismic design for nuclear power plant facilities in Japan is based on 'Examination Guide for Seismic Design of Nuclear Power Reactor Facilities: Nuclear Power Safety Committee, July 20, 1981' (referred to as 'Examination Guide' hereinafter) and the present design criteria have been established based on the survey of governmental improvement and standardization program. The detailed design implementation procedure is further described in 'Technical Guidelines for Aseismic Design of Nuclear Power Plants, JEAG4601-1987: Japan Electric Association'. This report describes the principles and design procedure of the seismic design of equipment/piping systems for nuclear power plant in Japan. (J.P.N.)

  5. Maintenance based design and equipment reliability for AECL's advanced CANDU reactor

    International Nuclear Information System (INIS)

    This paper will describe how the elements of AECL's Maintenance Based Design will enable the Advanced CANDU Reactor to sustain high equipment reliability and capacity factors over the 60-year design life of the plant. The elements of Maintenance Based Design are; 1-Design Reliable Systems,Structures and Components (SSCs); 2-Select and Procure Reliable Components; 3-Incorporate Monitoring Capabilities and Facilities for SSCs; 4-Develop Maintenance Strategies and Programs for SSCs; 5-Apply Lessons Learned From Previous Plants; 6-Incorporate Maintainability and Event Free Features in the Design; 7-Provide Enhanced Maintenance Management Information and Tools to the Customer; 8-Optimize Chemistry and Materials in the Design. All these elements will be discussed with a detailed focus on the following; Design Reliable SSCs Using the techniques outlined in INPO AP-913, Equipment Reliability Process Description, each CANDU system that has caused any station past unavailability is analyzed as part of the ACR design in order to identify the critical components and any Single Points of Vulnerability (SPVs). All SPVs are then analyzed further in order to determine if they can be practically designed out or otherwise mitigated by the design. Developing Maintenance Strategies and Programs for SSCs Equipment degradation begins as soon as a component is manufactured and accelerates during initial commissioning and eventual operation. In order to sustain high levels of equipment reliability a maintenance strategy must be developed during the design phase and be ready for implementation before the start of commissioning. This maintenance strategy is developed for all critical components using the techniques of INPO AP-913 and other best industry practices. The strategy can be expanded and customized in conjunction with a future owner. Specific examples from the current ACR-1000 design will be used to show how these elements are being implemented.

  6. Design and construction of the Portable Industrial X-Ray Equipment

    International Nuclear Information System (INIS)

    The main purposes of the project are the supporting to design and construction of the Portable Industrial X-Ray Equipment; with the accuracy ±2% of Output High Voltage 200 kV and Tube current 5 mA. The Equipment is composed of control unit, X-ray generator, and power cable, connection cable. X-ray generator is assembling construction X-ray tube, H.V transformer together with gas insulation (SF6) are sealed up in aluminum bucked cabinet, fan and heat-sink are mounted in the end of X-ray generator as cooling, SF6 is a gas electrical performance to H.V. Alarm lamp is used to warn, flashing, show generating X-ray. Control unit is box construction. Four printed circuit boards (PCB) and electronic device are mounted in it. All operating buttons switches and displays are equipped on the panel. We have completed to design and construct the Portable Industrial X-Ray Equipment; and have tested the electronic parameters of all test points and the main parameters of equipment (the accuracy ±2% of Output High Voltage 200 kV and Tube current 5 mA). We also have successful used the Portable Industrial X-Ray Equipment to evaluate the welds in industry. (author)

  7. Design and Construction of the Portable Industrial X-Ray Equipment

    International Nuclear Information System (INIS)

    The main purposes of the project are the supporting to design and construction of the Portable Industrial X-Ray Equipment; with the accuracy ±2% of Output High Voltage 200 kV and Tube current 5 mA. The Equipment is composed of control unit, X-ray generator, and power cable, connection cable. X-ray generator is assembling construction X-ray tube, H.V transformer together with gas insulation (SF6) are sealed up in aluminum bucked cabinet, fan and heat-sink are mounted in the end of X-ray generator as cooling, SF6 is a gas electrical performance to H.V. Alarm lamp is used to warn, flashing, show generating X-ray. Control unit is box construction. Four printed circuit boards (PCB) and electronic device are mounted in it. All operating buttons switches and displays are equipped on the panel. We have completed to design and construct the Portable Industrial X-Ray Equipment; and have tested the electronic parameters of all test points and the main parameters of equipment (the accuracy ±2% of Output High Voltage 200 kV and Tube current 5 mA). We also have successful used the Portable Industrial X-Ray Equipment to evaluate the welds in industry. (author)

  8. Preliminary design report for prototypical spent nuclear fuel rod consolidation equipment

    International Nuclear Information System (INIS)

    The purpose of the Prototypical Consolidation Demonstration Project (PCDP) is to develop and demonstrate the equipment system that will be used to consolidate the bulk of the spent nuclear fuel generated in the United States prior to its placement in a geological repository. The equipment must thus be capable of operating on a routine production basis over a long period of time with stringent requirements for safety, reliability, productivity and cost-effectiveness. Four phases are planned for the PCDP. Phase 1 is the Preliminary Design of generic consolidation equipment that could be installed at a Monitored Retrievable Storage (MRS) facility or in the Receiving ampersand Handling Facility at a geologic repository site. Phase 2 will be the Final Design and preparation of procurement packages for the equipment in a configuration capable of being installed and tested in a special enclosure within the TAN Hot Shop at DOE's Idaho National Engineering Laboratory. In Phase 3 the equipment will be fabricated and then tested with mock fuel elements in a contractor's facility. Finally, in Phase 4 the equipment will be moved to the TAN facility for demonstration operation with irradiated spent fuel elements. 55 figs., 15 tabs

  9. Design of a Prognostics and Health Management System for Electromechanical Equipment Through Time Stress Analysis

    Institute of Scientific and Technical Information of China (English)

    L(U) Ke-hong; QIU Jing; LIU Guan-jun

    2008-01-01

    Time stress includes all kinds of environment and operating stress such as shock, vibration, temperature and electric current that the electromechanical system suffers in the manufacture, transport and operating process. In this paper, the conception of time stress and prognostics and health management (PHM) system are introduced. Then, in order to improve the false alarm recognition and fault prediction capabilities of the electromechanical equipment, a novel PHM architecture for electromechanical equipment is put forward based on a built-in test (BIT) system design technology and time stress analysis method. Finally, the structure, the design and implementing method and the functions of each module of this PHM system are described in detail.

  10. Design and construction of prototype FBR 'Monju' equipments by Fuji Electric

    International Nuclear Information System (INIS)

    The prototype FBR 'Monju' which has been constructed by Power Reactor and Nuclear Fuel Development corporation has attained the initial criticality on April 5, 1994. Fuji Electric was in charge of the fuel handling and storage facilities, radioactive waste treatment facilities and radiation monitoring facilities from their design, manufacture to installation in the prototype FBR 'Monju'. As for these equipments, the specifications and structures were decided through the results of the construction and operation of the experimental FBR 'Joyo' and its design and various development tests. The manufacture of the equipments was carried out in Kawasaki Works, the measuring and control system in Tokyo Works, and the power source board in Kobe Works. The installation works, the functional tests of the single equipments, and the integrated functional test of the whole prototype FBR 'Monju' were carried out, and the facilities were delivered in December, 1992. The outline, the basic specifications, the design and development of the main equipments, the manufacture of the equipments and so on of respective facilities are described. The installation works and the tests at the site are reported. (K.I.)

  11. DOE/USDA joint project to design and manufacture prototype equipment

    Energy Technology Data Exchange (ETDEWEB)

    Fuller, J.G.

    1996-07-01

    Design, assembly, prove-in, and performance testing of prototype equipment for the United States Department of Agriculture`s Subtropical Agriculture Research Laboratory (SARL) were completed by the Department of Energy`s Kansas City Plant. The plant is operated by AlliedSignal Federal Manufacturing & Technologies (FM&T). The prototype equipment was developed as part of the USDA`s efforts to mass produce parasitic wasps for organic control of boll weevils in cotton crops. This development was part of the Production Capability Assurance Program and also part of the Work For Others program. Design and assembly of this prototype equipment led to some new FM&T processes and technologies and exercised many others as described in the text and, at the same time, met the needs of the USDA.

  12. Power system engineering planning, design, and operation of power systems and equipment

    CERN Document Server

    Schlabbach, Juergen

    2014-01-01

    With its focus on the requirements and procedures of tendering and project contracting, this book enables the reader to adapt the basics of power systems and equipment design to special tasks and engineering projects, e.g. the integration of renewable energy sources.

  13. Design and fabrication of equipment and devices for a Radiotherapy department

    International Nuclear Information System (INIS)

    The objective of this work is to present the possibility to design and construct utilizing local technology, a series of equipment and devices necessaries for a routine in a Radiotherapy Department with typical budget in the Latin-American hospitals. (Author)

  14. Two tools for environmentally conscious designers and product developers of electrical & electronic equipment (EEE)

    DEFF Research Database (Denmark)

    Poll, Christian; Hauschild, Michael Zwicky; Olsen, Stig Irving;

    2002-01-01

    The paper presents the two tools 1)"Product families - short cuts to environmental knowledge" and 2)"Eco-conscious design of electrical & electronic equipment (EEE)". Tool 1) comes in form of a handbook. The purpose of this handbook is to ease the work with developing more environmentally sound...

  15. Prototypical spent fuel rod consolidation equipment preliminary design report: Volume 2, Drawings

    International Nuclear Information System (INIS)

    This volume consists of 65 E size drawings and 4 sketches of the NUS spent fuel rod consolidation equipment. The drawings have been grouped into categories; a detailed list of the drawings is included. The sketches prepared during the preliminary design process have been included

  16. On Syllabus Design for the Specialty of Electromechanical Equipment Maintenance and Management in Vocational College

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    We carried out researches on the syllabus design for the specialty of electromechanical equipment maintenance & management in vocational college. Our researches involve the following aspects: (1) The training objective of the specialty; (2) the curriculum system; (3) The teaching methodology; and (4) Field training.

  17. Interaction and educational design of mobile equipment for crisis management training

    DEFF Research Database (Denmark)

    Ørngreen, Rikke

    2011-01-01

    discussion, where the empirical data have to do with first aid in general and training cardiocerebral resuscitation in office settings specifically. Consequently, the paper contains design ideas, analysis and evaluation of current work with mobile equipment and augmented reality features, utilizing...

  18. Development of medical X-ray equipment for fluoroscopy: The design

    International Nuclear Information System (INIS)

    Medical x-ray equipment for fluoroscopy is producing an image that visualized in the fluorescent screen. In a conventional system, in order to diagnose the patient, typically the physician directly observed the phosphorescent screen. Thus, physician will be at risk of radiation exposure from x-ray tube. Therefore, there is a need to modify the conventional fluoroscopic x-ray equipment in order to reduce the risk of radiation exposure to the physician or operator. In the equipment to be developed, image data will be transferred to computer system via a CCD camera as a digital image. Using the computer, the image then will be proceed and displayed in the monitor in control room. The observation of the image can be done by the physician in the control room to reduce radiation exposure. In this paper, we will discuss the design of the x-ray equipment for fluoroscopy that will be developed. The prototype of the equipment will be created in the next term of the research based on the design presented here. (author)

  19. Design and tests of the screw denitration equipment using microwave heating

    International Nuclear Information System (INIS)

    A continuous denitration equipment which uses a microwave heating technique is designed and tested. A screw is incorporated for feeding material. Major features of this technique include easiness of pellet molding due to high activity of powder, decreased amount of waste and waste liquid released and easy operation and maintenance due to simplified processes. The equipment consists of a solution supply pipe, denitrated material discharge pipe, microwave guide, offgas exhaust pipe and screw feeder, all of which are connected to a denitration oven. Tests are performed for determining microwave absorption efficiency, processing capacity and performance. Cerium nitrate solution is employed as sample to simulate uranyl nitrate solution. Parameters used include the solution retention volume, inclination of the screw shaft, clearance between the screw and the trough, and solution concentration. The maximum microwave absorption efficiency is found to be 50 percent. Measurements also show that the equipment requires 3.5 - 4.5 hours to reach a stationary state. The size of dried material depends on the revolution speed of the screw. In the performance confirmation test, the equipment is operated continuously for 52 hours while measuring the fluctuation in the torque of the screw motor shaft and the properties of dried material discharged. Results show that the equipment can operate continuously while meeting the design conditions. (Nogami, K.)

  20. Analysis and design recommendation on rabbeted capping plate of equipment cell in nuclear chemical facility

    International Nuclear Information System (INIS)

    Rabbeted capping plates are widely used in the roof of equipment cells in order to meet the requirements of nuclear radiation protection. The key considerations in the design include vertical load, seismic load and repair load. This article establishes T shaped and Z-shaped plate model via FEM software (ANSYS), analyzes the bearing capacity and displacement distribution in different load cases, and provides recommendations to the design and construction accordingly. (authors)

  1. A novel compact design of calibration equipment for gas and thermal sensors

    Energy Technology Data Exchange (ETDEWEB)

    Feng, P. X.; Zhang, H. X.; Peng, X. Y.; Sajjad, M.; Chu, J. [Institute for Functional Nanomaterials and Department of Physics, University of Puerto Rico, P.O. Box 70377, San Juan, 00936-8377 (Puerto Rico)

    2011-04-15

    A novel design of calibration equipment has been developed for static and dynamic calibrations of gas and thermal sensors. This system is cheap, compact, and easily adjustable, which is also combined with a plasma surface modification source for tailoring the surface of sensors to ensure the sensitivity and selectivity. The main advantage of this equipment is that the operating temperature, bias voltage, types of plasma source (for surface modification), types of feeding gases, and gas flow rate (for calibrations), etc., can be independently controlled. This novel system provides a highly reliable, reproducible, and economical method of calibrations for various gas and thermal sensors.

  2. Mechanical design for positioning of GM detector for system of avian flu virus detection equipment

    International Nuclear Information System (INIS)

    Mechanical design for positioning of GM detector system has been done. It is used for avian flu detection equipment. The requirements for the design are to protect detection system against shock, portable, and easy to maintain. The mechanical system consists of connectors, cable assemblies, holders, casing, housing and detectors cover. The selected material should have small gamma radiation absorption property in order to give optimum counts for the detector. The design result should give a system that is easy to operate, cheap and easy to assemble. (author)

  3. A mechanical design for positioning of gm detector for system of avian flu virus detection equipment

    International Nuclear Information System (INIS)

    Mechanical design for positioning of GM detector system has been done. It is used for avian flu detection equipment. The requirements for the design are to protect detection system against shock, portable, and easy to maintain. The mechanical system consists of connectors, cable assemblies, holders, casing, housing and detectors cover. The selected material should have small gamma radiation absorption property in order to give optimum counts for the detector. The design result should give a system that is easy to operate, cheap and easy to assemble. (author)

  4. Design of phantoms and software for automatic image analysis applied to digital radiographic equipments

    International Nuclear Information System (INIS)

    In a quality control of the radiographic equipment, the quality of the obtained image is very useful to characterize the physical properties of the image radiographic chain. In the radiographic technique it is necessary that the evaluation of the image can guarantee the constancy of its quality to carry out a suitable diagnosis. The use of digital systems allows the automatic analysis of the obtained radiographic images, increasing the objectivity in the evaluation of the image. In this work we have designed some radiographic phantoms for different radiographic digital devices, as dental, conventional, equipments with computed radiography (phosphor plate) and direct radiography (sensor) technology. Additionally, we have developed a software to analyse the image obtained by the radiographic equipment with digital processing techniques as edge detector, morphological operators, statistical test for the detected combinations.. The images have been acquired in DICOM, tiff.. format and they can be analysed with objective parameters as an image quality index and the contrast detail curve. The design of these phantoms let the evaluation of a wide range of operating conditions of voltage, current and time of the digital equipments. Moreover, the image quality analysis by the automatic software let study it with objective parameters and the functioning of the image chain of the digital system. (author)

  5. Prototypical spent fuel rod consolidation equipment preliminary design report: Volume 1, Report

    International Nuclear Information System (INIS)

    This design report describes the NUS Preliminary Design of the Prototype Spent Nuclear Fuel Rod Consolidation Equipment for the Department of Energy. The sections of the report elaborate on each facet of the preliminary design. A concept summary is provided to assist the reader in rapidly understanding the complete design. The NUS Prototype Spent Fuel Rod Consolidation System is an automatically controlled system to consolidate a minimum of 750 MT (heavy metal)/year of US commercial nuclear reactor fuel, at 75% availability. The system is designed with replaceable components utilizing the latest state-of-the-art technology. This approach gives the system the flexibility to be developed without costly development programs, yet accept new technology as it evolves over the next ten years. Capability is also provided in the system design to accommodate a wide variety of fuel conditions and to recover from any situation which may arise

  6. Design considerations, tooling, and equipment for remote in-service inspection of radioactive piping and pressure-vessel systems

    International Nuclear Information System (INIS)

    This paper summarizes results obtained in use of remotely-operated nondestructive testing (NDT) equipment for inspection of reactor-system components. Experience obtained in operating the Fast Flux Test Facility (FFTF) has provided a basis for field verification of remote NDT equipment designs and has suggested development improvements. Remote Viewing and data gathering systems used include periscopes, borescopes, fiberscopes, hybrid borescopes/fiberscopes, and closed circuit television. A summary of design consideration for inspection equipment and power plant design is presented to achieve improved equipment operation and reduction of plant maintenance downtime

  7. Design and implementation of equipment for monitoring the salinity in the subsoil

    Directory of Open Access Journals (Sweden)

    Mariano Norzagaray Campos

    2012-09-01

    Full Text Available Geochemical exploration equipments to explore the contaminants and structures geological in the subsoil come from abroad are expensive and sometimes parts for replacement are not available in the market. So it is necessary design apparatus that meet cover these needs. To the monitoring of variations in salinity there is semi-automatic equipment, but it always has difficult to manage. However, is not equipment for the indirect study of salinity in the subsoil. In this work was design equipment for measurement the apparent resistivity in the subsoil, at same time allow know the salinity, as well as the detection of any pollutant in groundwater. For make it, was selected a design of earthing systems, with electronic hardware which were jointed for apply to subsoil a direct current (DC through an array dipole-dipole and vertical electric sounding, with brass and stainless steel electrodes. In the earthing systems the electrodes were collocated in the equidistant line between the detectors of potential and current. A geometric factor (K, that depend on theelectrodes distance and direct current (I injected in the electrodes A and B, was used for measure the potential difference between the electrodes M and N; after was calculate the resistivity point to point for obtain a subsoil tomography geoelectrical. The equipment was calibrated with minimum error (rms < 2% whit respect to curves obtained in similar commercial equipment. On this situation, in this work was modernized and automated an equipment to determine thesalinity of the subsoil. The instrument was tasted in the micro basin Texcoco, State of Mexico, to define the environment geometry formed by alluvial or lake sediments from igneous rocks (andesites, rhyolites and tuffs vitreous or “tepetates” which by its mineralogical composition allowed to the lateral resistivity be associate with free components trace from the aquifer: Cd, Cu, Cr, Co, Ni, Pb or Zn and others. This method constitutes

  8. System design, construction, and start-up of the Hanford Site Transportable Grout Equipment facility

    International Nuclear Information System (INIS)

    The US Department of Energy (DOE) and Westinghouse Hanford Company (Westinghouse Hanford) have developed a grouting process for the immobilization and final disposal of mixed low-level tank wastes from various Hanford N-Reactor operations. Associated Technologies, Inc. (ATI), now part of US Ecology Nuclear, was selected to design, construct, and start-up the Transportable Grout Equipment (TGE) facility with technical assistance from SGN of France

  9. Analysis of possible schemes for twisting multiwire superconducting cables and design of twisting equipment

    International Nuclear Information System (INIS)

    Possible technological schemes for obtaining superconducting twisted cables are presented. The advantages and disadvantages of the twisting schemes and deformations of the superconduct ing wires when being twisted are analyzed. The causes of the twist step instabilities are considered and recommendations on choosing the twisting scheme satisfying the requirements imposed on the twisted cables are presented. Brief information on the designed and used in industry equipment for superconductor twisting is given. 8 refs.; 8 figs.; 2 tabs

  10. Research and Design of Sleeve Detach and Reunion Drive Mechanism of Screw Melt Extruder Equipment

    Institute of Scientific and Technical Information of China (English)

    Xiude ZHANG

    2012-01-01

    The design of sleeve detach and reunion drive device of screw melt ex- truder equipment was optimized, based on the present installation of hygraulic drive device to achieve the mechanical opening and closing of the sleeve, the dynamic model of the sleeve detach and reunion drive was theoretically measured, and it was verified that the device is simple to operate and convenient to maintain, thus it has great social values.

  11. Vibration Control Systems for Sensitive Equipment: Limiting Performance and Optimal Design

    OpenAIRE

    Ryaboy, V.M.

    2005-01-01

    As vibration control requirements become increasingly stringent, designers and users of vibration control equipment turn to devices and systems combining various physical mechanisms. Subsystems based on different physical effects can be combined to achieve the optimal performance for the application. Building an optimal product line that would cover a wide field of applications by combining several products, as opposed to creating one optimal device for a particular application, presents an o...

  12. Identifying the essential factors in the marketing mix design (The case of Personal Protective Equipment)

    OpenAIRE

    2012-01-01

    This research intends to focus on establishing an easier methodology for determining a marketing mix that a startup company can use. It can also help established companies in an early phase assessment of their marketing mix. The study focuses on this methodology through the case of PPE (Personal Protective Equipment) by identifying the essential factors in the marketing mix design for it. Marketing a product requires that the product has a right mix of all the four P’s- Product, Place, Price ...

  13. Thermally modulated biomolecule transport through nanoconfined channels

    Science.gov (United States)

    Liu, Lei; Zhu, Lizhong

    2015-04-01

    In this work, a nanofluidic device containing both a feed cell and a permeation cell linked by nanopore arrays has been fabricated, which is employed to investigate thermally controlled biomolecular transporting properties through confined nanochannels. The ionic currents modulated by the translocations of goat antibody to human immunoglobulin G (IgG) or bovine serum albumin (BSA) are recorded and analyzed. The results suggest that the modulation effect decreases with the electrolyte concentration increasing, while the effects generated by IgG translocation are more significant than that generated by BSA translocation. More importantly, there is a maximum decreasing value in each modulated current curve with biomolecule concentration increasing for thermally induced intermolecular collision. Furthermore, the turning point for the maximum shifts to lower biomolecule concentrations with the system temperature rising (from 4°C to 45°C), and it is mainly determined by the temperature in the feed cell if the temperature difference exists in the two separated cells. These findings are expected to be valuable for the future design of novel sensing device based on nanopore and/or nanopore arrays.

  14. Radio frequency sputtering equipment: design considerations for the disc and annulus system

    International Nuclear Information System (INIS)

    The basic equations important in the design of rf sputtering equipment are presented. Attention is restricted to the 'disc and annulus' system and simple techniques in lead-through fabrication and electrode shielding are described. Also rf power oscillator theory is used to derive the important parameters of power generation. Load coupling and power matching techniques are discussed. Problems of the magnetic field coil design are analysed and a value for the thermal conductivity of coils wound from polyurethane coated wire is given, namely k = 0.64 W m-1/0C-1, permitting the steady state temperature distribution inside such coils to be predicted. (author)

  15. Research and design of the main equipments and structure of Xiangjiaba shiplift

    Institute of Scientific and Technical Information of China (English)

    Liao Lekang; Zhu Hong; Zhang Rui

    2014-01-01

    The type of pinion and rack vertical shiplifts has been developed in recent a couple of years in the construction of dams. But the design methods and methodologies have rarely been discussed in literature. The Xiangjiaba shiplift is the second shiplift of this type following the Three Gorges shiplift. Being aimed at the technological rationality of the design in synthetically considering security,economy and applicability,this pa-per presents the research results of some vital issues relating the design of the Xiangjiaba shiplift,including the determination of design water depth of ship chamber based on fluid numeral computation and physical model test,the optimum design of general layout of main equipments and the civil structure of the Xiangjiaba shiplift, the finite element method (FEM) analysis of stress,vibration modes and the buckling of ship chamber,anti-seismic research and the design of structures and mechanisms of the shiplift and the optimum design of driving mechanisms. This research provides the theoretical basis for the design of the Xiangjiaba shiplift. The design principles and research methods are valuable for the design of the same type of shiplifts.

  16. Design and installation of extra high voltage cryogenic dielectric test facilities for the superconducting electric equipment

    International Nuclear Information System (INIS)

    We installed high voltage cryogenic dielectric test facilities including big FRP cryostat. We designed 3 m long and 2 m wide cryostat system with busing. Low temperature and high voltage bushing were fabricated and tested. CF4 gas shows excellent characteristics in low temperature insulation. High voltage bushing could be modified for low temperature environment. Superconducting electric equipments have a lot of advantages over the conventional devices such as improvements in overall efficiency, size reduction, high current carrying capability, and also environment-friendly products. Owing to these advantages, many research institutes have been tried to develop commercial superconducting devices, which could be applicable to the high voltage and high current electric networks. But up to now, most of the research works to develop commercial products were delayed because it was not easy to acquire reliable high voltage insulation properties and optimum insulation design skills considering extremely low temperature environments. Furthermore, it was difficult to determine optimum high voltage insulation level due to the lack of high voltage cryogenic dielectric test facilities. Thus, in order to establish the cryogenic dielectric technology regarding insulating design, cryogenic dielectric test skills, and to implement more reliable high voltage superconducting devices, high voltage cryogenic dielectric test facilities should be prepared for extra high voltage superconducting electric equipments. Recently, cryogenic dielectric test facilities were installed including 3 m long 2 m wide cryostat system with bushing, and 1.6 MVA lightening impulse generators, 400 kVA AC overvoltage test system in Korea. In this paper, design and installation of high voltage cryogenic dielectric test system including very big size FRP cryostat and high voltage bushing were minutely introduced. And some test results to develop high voltage bushings for liquid nitrogen cryostat in order to

  17. Simulating biomolecules in cellular environments

    Czech Academy of Sciences Publication Activity Database

    Feig, M.; Tanizaki, S.; Chocholoušová, Jana; Sayadi, M.; Clifford, J. W.; Connelly, B. D.; Mukherjee, S.; Law, S. M.

    Jüllich : John von Neumann Institute for Computing, 2008 - (Hansmann, U.; Meinke, J.; Mohanty, S.), s. 23-30 ISBN 978-3-9810843-6-8. - ( NIC Series. 40). [From Computational Biophysics to Systems Biology (CBSB08). NIC Workshop 2008. Jülich (US), 19.05.2008-21.05.2008] Institutional research plan: CEZ:AV0Z40550506 Keywords : generalized Born formalism * implicit solvent * biomolecules Subject RIV: CC - Organic Chemistry http://www.fz-juelich.de/ nic -series/volume40

  18. BSDB: the biomolecule stretching database

    OpenAIRE

    Sikora, Mateusz; Sułkowska, Joanna I.; Bartłomiej S. Witkowski; Cieplak, Marek

    2010-01-01

    We describe the Biomolecule Stretching Data Base that has been recently set up at http://www.ifpan.edu.pl/BSDB/. It provides information about mechanostability of proteins. Its core is based on simulations of stretching of 17 134 proteins within a structure-based model. The primary information is about the heights of the maximal force peaks, the force–displacement patterns, and the sequencing of the contact-rupturing events. We also summarize the possible types of the mechanical clamps, i.e. ...

  19. Implementation design of the remote control equipment and device development facility

    International Nuclear Information System (INIS)

    In Nuclear Plant Decommissioning Safety Research Establishment of Sector of Fukushima Research and Development of JAEA, implementation design of the remote control equipment and device development facility has been performed for R and D of decommissioning of TEPCO'S Fukushima Daiichi Nuclear Power Station. This facility consists of the testing building for various demonstration tests and the research control building for equipment of worker training and user's workroom. The demonstration test area for the technique to repair a water leakage at the PCV, development and demonstration test area for the remote controlled devices and the shareable area, are prepared in the testing building, assuming that the two types of tests are performed in parallel. Furthermore, the accessory building, consists of researcher's rooms and workshops for development/demonstration tests of disaster response robots, is prepared in the testing building. The research control building consists of worker training rooms, user's rooms, office rooms and multipurpose area. In the multipurpose room, it is also possible to hold international conferences. This report summarized the result of implementation design of the remote control equipment and device development facility. In addition, construction of this facility was started in September 2014. (author)

  20. Problem-oriented system of design of technology of equipment dismantling at NPP units decommissioning

    International Nuclear Information System (INIS)

    The principles for construction of the problem-oriented system for designing the NPP equipment dismantling technology during power unit decommissioning are considered. The rules of the design space organization and use basing on application of the information and expert methods taking into account the action of the factors characterizing the technology functioning medium effects are applied as initial elements for the system construction. The general scheme for building the models used when developing the equipment dismantling technology is described in details. It is shown that the technological principles of conducting the works connected with the equipment dismantling are mostly determined by the work volumes. The basic variant of NPP power unit decommissioning under modern conditions in Russia involves safe monitored storage with final reactor dismantling after long time period (for 30-100 years) in order to provide its components activity decreasing due to natural radioactive nuclide decays. At that the main condition for dismantling technology functioning is following the radiation safety requirements for personnel, population and environment

  1. Design validation of the 4S high temperature electromagnetic pump by one pole segment test equipment

    International Nuclear Information System (INIS)

    The small fast reactor 4S (Super Safe Small and Simple) adopts high temperature sodium immersed electromagnetic pump (EMP) as a primary pump. The reason is that EMP is able to satisfy the low maintenance, safety and reliability requirements for 4S, because it has simple structure and no moving parts. Technical challenges of 4S EMP are the following three items.The first is to confirm manufacturability of 4S EMP. 4S EMP has the world greatest dimension coil and stator and flattened shape with the aspect ratio (outer diameter / stator length) of 1.8. The 4S prototype EMP as same as practical dimension and the one pole segment test equipment were manufactured in JFY 2008. The second is to construct the back up power supply system for flow coast down. It will be confirmed by combination test of 4S prototype EMP and the system in JFY 2010. The third is to confirm low maintenance for 30 years. A part of long-term soundness test of coil is tested by heat cycle test with one pole test equipment discussed in the next section. Furthermore, as the future development subject, the seismic assessment and the long-term soundness test of the EMP body by the sodium fluid test has been planned. The one pole segment test equipment is used for evaluation of following items. The first is the integrity of the electrical insulation of large diameter coil. Insulation breakdown will be estimated due to thermal expansion in coil during operation, thus, the heat cycle is loaded to the equipment simulating start-and-stop of 4S. Insulation resistance, leak current and tan δ will also be measured in several steps of coil temperature. The second is validation whether stator support system of the EMP would work as designed. In practical 4S EMP, all of Joule heat by energization of the coil during operation is transferred into sodium through core and duct. To keep the heat transfer system, in the outer stator, the core is pressed upon the duct by spring plates. Therefore, it is important to

  2. Study on compact design of remote handling equipment for ITER blanket maintenance

    International Nuclear Information System (INIS)

    In the ITER, the neutrons created by D-T reactions activate structural materials, and thereby, the circumstance in the vacuum vessel is under intense gamma radiation field. Thus, the in-vessel components such as blanket are handled and replaced by remote handling equipment. The objective of this report is to study the compactness of the remote handling equipment (a vehicle/manipulator) for the ITER blanket maintenance. In order to avoid the interferences between the blanket and the equipment during blanket replacement in the restricted vacuum vessel, a compact design of the equipment is required. Therefore, the compact design is performed, including kinematic analyses aiming at the reduction of the sizes of the vehicle equipped with a manipulator handling the blanket and the rail for the vehicle traveling in the vacuum vessel. Major results are as follows: 1. The compact vehicle/manipulator is designed concentration on the reduction of the rail size and simplification of the guide roller mechanism as well as the reduction of the gear diameter for vehicle rotation around the rail. Height of the rail is reduced from 500 mm to 400 mm by a parameter survey for weight, stiffness and stress of the rail. The roller mechanism is divided into two simple functional mechanisms composed of rollers and a pad, that is, the rollers support relatively light loads during rail deployment and vehicle traveling while a pad supports heavy loads during blanket replacement. Regarding the rotation mechanism, the double helical gear is adopted, because it has higher contact ratio than the normal spur gear and consequently can transfer higher force. The smaller double helical gear, 996 mm in diameter, can achieve 26% higher output torque, 123.5 kN·m, than that of the original spur gear of 1,460 mm in diameter, 98 kN·m. As a result, the manipulator becomes about 30% lighter, 8 tons, than the original weight, 11.2 tons. 2. Based on the compact design of the vehicle/manipulator, the

  3. BSDB: the Biomolecule Stretching Database

    Science.gov (United States)

    Cieplak, Marek; Sikora, Mateusz; Sulkowska, Joanna I.; Witkowski, Bartlomiej

    2011-03-01

    Despite more than a decade of experiments on single biomolecule manipulation, mechanical properties of only several scores of proteins have been measured. A characteristic scale of the force of resistance to stretching, Fmax , has been found to range between ~ 10 and 480 pN. The Biomolecule Stretching Data Base (BSDB) described here provides information about expected values of Fmax for, currently, 17 134 proteins. The values and other characteristics of the unfolding proces, including the nature of identified mechanical clamps, are available at www://info.ifpan.edu.pl/BSDB/. They have been obtained through simulations within a structure-based model which correlates satisfactorily with the available experimental data on stretching. BSDB also lists experimental data and results of the existing all-atom simulations. The database offers a Protein-Data-Bank-wide guide to mechano-stability of proteins. Its description is provided by a forthcoming Nucleic Acids Research paper. Supported by EC FUNMOL project FP7-NMP-2007-SMALL-1, and European Regional Development Fund: Innovative Economy (POIG.01.01.02-00-008/08).

  4. A Knowledge-Based Approach for Selection of Material Handling Equipment and Material Handling System Pre-design

    OpenAIRE

    YAMAN, Ramazan

    2001-01-01

    For material handling system design, material handling equipment selection is the first stage. Also the material handling system and facility layout design problems are coupled. Solving these problems needs consideration of these three different problems. Right material handling equipment selection and good design of the material handling system and facility layout can increase productivity and reduce investments and operations' costs. In this study, after describing the mater...

  5. Equipment Design and Cost Estimation for Small Modular Biomass Systems, Synthesis Gas Cleanup, and Oxygen Separation Equipment; Task 9: Mixed Alcohols From Syngas -- State of Technology

    Energy Technology Data Exchange (ETDEWEB)

    Nexant Inc.

    2006-05-01

    This deliverable is for Task 9, Mixed Alcohols from Syngas: State of Technology, as part of National Renewable Energy Laboratory (NREL) Award ACO-5-44027, ''Equipment Design and Cost Estimation for Small Modular Biomass Systems, Synthesis Gas Cleanup and Oxygen Separation Equipment''. Task 9 supplements the work previously done by NREL in the mixed alcohols section of the 2003 technical report Preliminary Screening--Technical and Economic Assessment of Synthesis Gas to Fuels and Chemicals with Emphasis on the Potential for Biomass-Derived Syngas.

  6. Final design and start-up of the transportable grout equipment facility at Hanford

    International Nuclear Information System (INIS)

    The U.S. Department of Energy and its Hanford operations contractors have designated certain low-level radioactive liquid wastes to be immobilized by means of a grouting process. The process is now being implemented on a production basis under the management of the Westinghouse Hanford Company (WHC). Associated Technologies, Incorporated (ATI) has completed the design, fabrication, and installation of the Transportable Grout Equipment (TGE) Facility, the waste processing unit of the overall storage, treatment and disposal system. SGN of France under contract to ATI assisted with remote maintenance design considerations and field start-up support. The TGE Facility provides for the remotely-operated mixing of the selected liquid wastes with the dry grout solids and delivery of the resulting slurry to the disposal vaults where solidification occurs. TGE includes the processing module and all necessary control and supporting systems for safe, self-contained operation. All processing and support modules have been fabricated, delivered, and installed

  7. Aseismic design of structure-equipment systems using variable frequency pendulum isolator

    International Nuclear Information System (INIS)

    Sliding isolation systems have emerged as very useful vibration control technique that incorporate isolation, energy dissipation and restoring mechanism in one unit. However, most currently available systems such as friction pendulum system (FPS) and pure friction (PF) system have practical limitations and are of limited effectiveness when input excitation level is significantly different from its design level. To overcome these limitations while preserving the advantages, a new system called the variable frequency pendulum isolator (VFPI) has been developed by the authors. The isolation period of VFPI continuously decreases with increase in horizontal sliding displacement which results in a more robust isolation system. The VFPI also limits the maximum force transmitted to the structure by providing a restoring force-softening mechanism. In this paper, it has been shown that isolating a structure using VFPI is very effective for vibration control of structure-equipment and other primary-secondary systems. An example five-storey structure with equipment mounted at its top has been analysed to demonstrate the effectiveness of VFPI. It is shown that VFPI provides better vibration control properties compared to other friction isolation systems, and excellent response reduction is observed for a wide range of equipment properties and excitation characteristics. The performance of the example structure with VFPI has been compared with the other frictional systems such as FPS and PF system

  8. Design for Reliability of Complex System: Case Study of Horizontal Drilling Equipment with Limited Failure Data

    Directory of Open Access Journals (Sweden)

    Morteza Soleimani

    2014-01-01

    Full Text Available Reliability is an important phase in durable system designs, specifically in the early phase of the product development. In this paper, a new methodology is proposed for complex systems’ design for reliability. Specific test and field failure data scarcity is evaluated here as a challenge to implement design for reliability of a new product. In the developed approach, modeling and simulation of the system are accomplished by using reliability block diagram (RBD method. The generic data are corrected to account for the design and environment effects on the application. The integral methodology evaluates reliability of the system and assesses the importance of each component. In addition, the availability of the system was evaluated using Monte Carlo simulation. Available design alternatives with different components are analyzed for reliability optimization. Evaluating reliability of complex systems in competitive design attempts is one of the applications of this method. The advantage of this method is that it is applicable in early design phase where there is only limited failure data available. As a case study, horizontal drilling equipment is used for assessment of the proposed method. Benchmarking of the results with a system with more available failure and maintenance data verifies the effectiveness and performance quality of presented method.

  9. Development of processing procedure preparing for digital computer controlled equipment on modular design base

    International Nuclear Information System (INIS)

    In order to reduce labour consumption of technological preparation of production for digital computer controlled machines during the treatment of steam turbines articles created is a system of modular design of technological processes and controlling programs. A set of typical modulas-transitions, being a number of surfaces of an articles treated with one cutting tool in optimum sequence, and a library of cutting tools are the base of the system. Introduction of such a system sharply enhaneces the efficiency of the equipment utilization

  10. Project and design of apparatus and equipment of pilot plant experimental bituminization line PS 44 EBO

    International Nuclear Information System (INIS)

    The modifications are described made in the design of major components of the pilot plant experimental bituminization line involving: the mixing equipment, the film rotor evaporator, the calciner, and various transport mechanisms for handling drums and containers. The difficulty and complexity of the problem which Kralovopolska strojirna Brno, the end supplier of the bituminization line, will have to tackle is evident mainly from the case of bridge cranes, which feed the line, and the full-portal gantry crane which handles the containers and drums at regional sites of radioactive waste disposal. (Z.M.)

  11. Design validation of the 4S high temperature electromagnetic pump by one pole segment test equipment

    International Nuclear Information System (INIS)

    Toshiba has developed the Super-Safe, Small and Simple sodium-cooled reactor, named as 4S. 4S has the features that the passive safety design, no on-site refuelling for 30 years, the low maintenance. 4S adopts a high temperature sodium immersed electromagnetic pump (EM pump) as the primary pump. The coil diameter of 4S EM pump is one and a half times as larger than that of 160 m3/min EM pump which Toshiba has already developed. To confirm the manufacturability of the large diameter coil with the high temperature insulation and the large size stator, the one pole segment test equipment, which has one-sixth height and same size radius of 4S EM pump, was manufactured. In this paper, the test results of the one pole segment test equipment are reported. It was confirmed the structural integrity of EM pump caused by the electromagnetic oscillation by the energization of a coil. By the heat cycle test, it was able to confirm the structural integrity during the operation of 4S EM pump and the insulation performance in the high-temperature environment. These test results would be reflected the design and the manufacture of 4S EM pump. (author)

  12. An Expert System for Supporting the Design and Selection of Mechanical Equipment for Recreational Crafts

    Directory of Open Access Journals (Sweden)

    T. Gonciarz

    2014-06-01

    Full Text Available Expert Systems can be defined as computer programs, whose main task is to simulate a human expert, usually in a narrow field of expertise. Expert Systems have experienced tremendous growth and popularity since their commercial introduction in the early 1970’s. Today, Expert Systems are used in business, science, engineering, manufacturing and other engineering applications such as planning, scheduling, diagnosing equipment failures and are used in almost every stage of the manufacturing process and also in medicine and many other fields. Expert Systems belong to the field of artificial intelligence. An intelligent computer program that uses knowledge and inference procedures to solve problems that are difficult enough to require significant human expertise for the solution. The purpose of this paper is to present an Expert System which assists with the design of yachts and supports the selection of mechanical equipment for yachts and includes knowledge in the field of yachting engineering. Using the presented Expert System reduces the time during the design and production preparation process.

  13. Effect of extraction solvents on the biomolecules and antioxidant properties of Scorzonera undulata (Asteraceae: Application of factorial design optimization phenolic extraction

    Directory of Open Access Journals (Sweden)

    Khaled Athmouni

    2015-12-01

    Full Text Available Background. Phenolic compounds were extracted and isolated from S. undulata roots. Methods. Sample of roots from E. hirta was tested for phenolic compounds, and in vitro antioxidant activity by diphenyl-1-picrylhydrazyl (DPPH assay, ABTS, FRAP and reducing power was measured using cyano- ferrate method. Results. The methanolic fraction exhibited the highest total phenol content (6.12 ±0.11 mg AGE/g DW. On the other hand, the highest flavonoids concentration was observed in ethyl acetate fraction (2.90 ±0.05 mg CE/g DW in addition to anthocyanins (28.56 ±3.96 mg/l. Besides, the highest level of tannins content was measured in the polar aprotic solvent ethyl acetate extract (3.25 ±0.06 mg CE/g DW. The different extracts of S. undulata were evaluated for their radical scavenging activities by means of the DPPH assay. The strongest scavenging activity was observed in methanolic fraction scavenged radicals effectively with IC   values of 0.14 ±0.02 mg/ml. Similarly, the potassium ferricyanide reduction (FRAP and ABTS•+ of methanol extract. On the other hand, the total reducing power of ethyl acetate extract was found higher than of other extracts. This paper presents the application of the design-of experiment method for optimizing the extraction of phe- nolic content using methanol solvent. The resulting regression model has shown that the effect of temperature is not statistically significant (with >95% certainty, while that of agitation speed is. The two main effects are contributed by the solvent concentration and the maceration period. Conclusion. Our results clearly showed that the extraction of phenolic compounds and their antioxidant ca- pacity is significantly affected by solvent combinations. S. undulata presented the highest total phenolic con- tent, total flavonoids content and antioxidant capacity values. The resulting regression model has shown that the effect of temperature is not statistically significant (with >95

  14. Cell and biomolecule delivery for regenerative medicine

    International Nuclear Information System (INIS)

    Regenerative medicine is an exciting field that aims to create regenerative alternatives to harvest tissues for transplantation. In this approach, the delivery of cells and biological molecules plays a central role. The scaffold (synthetic temporary extracellular matrix) delivers cells to the regenerative site and provides three-dimensional environments for the cells. To fulfil these functions, we design biodegradable polymer scaffolds with structural features on multiple size scales. To enhance positive cell-material interactions, we design nano-sized structural features in the scaffolds to mimic the natural extracellular matrix. We also integrate micro-sized pore networks to facilitate mass transport and neo tissue regeneration. We also design novel polymer devices and self-assembled nanospheres for biomolecule delivery to recapitulate key events in developmental and wound healing processes. Herein, we present recent work in biomedical polymer synthesis, novel processing techniques, surface engineering and biologic delivery. Examples of enhanced cellular/tissue function and regenerative outcomes of these approaches are discussed to demonstrate the excitement of the biomimetic scaffold design and biologic delivery in regenerative medicine. (topical review)

  15. Cell and biomolecule delivery for regenerative medicine

    Directory of Open Access Journals (Sweden)

    Ian O Smith and Peter X Ma

    2010-01-01

    Full Text Available Regenerative medicine is an exciting field that aims to create regenerative alternatives to harvest tissues for transplantation. In this approach, the delivery of cells and biological molecules plays a central role. The scaffold (synthetic temporary extracellular matrix delivers cells to the regenerative site and provides three-dimensional environments for the cells. To fulfil these functions, we design biodegradable polymer scaffolds with structural features on multiple size scales. To enhance positive cell–material interactions, we design nano-sized structural features in the scaffolds to mimic the natural extracellular matrix. We also integrate micro-sized pore networks to facilitate mass transport and neo tissue regeneration. We also design novel polymer devices and self-assembled nanospheres for biomolecule delivery to recapitulate key events in developmental and wound healing processes. Herein, we present recent work in biomedical polymer synthesis, novel processing techniques, surface engineering and biologic delivery. Examples of enhanced cellular/tissue function and regenerative outcomes of these approaches are discussed to demonstrate the excitement of the biomimetic scaffold design and biologic delivery in regenerative medicine.

  16. Thermal control for space microelectronic equipment via pyroelectric material: Design, characterisation and experimental campaign

    Science.gov (United States)

    Monti, Riccardo; Gasbarri, Paolo; Lecci, Umberto

    2012-12-01

    In the last decades the development of new satellite platforms from a smaller to a bigger size goes in parallel with the development of the microelectronics equipment boarded on. Avionics, control systems and payloads equipment exploit the microelectronics in order to reduce the overall dimensions and masses and to increase the performances of each unit for the improvement of goals in each mission. A larger use of electronic elements with the relevant components increases the importance of a carefully equipment designed under different points of view. One of them is the thermal management. It is well known that the Joule Effect causes the heat overstocking which in turn reduces the efficiency of the electronic devices and increases the difficulties to manage the thermal power budget on board. A new design philosophy sees a possibility for a simpler and a more efficient thermal control on the use of the pyroelectric materials. Pyroelectrics are a "special" class of materials that demonstrates a spontaneous capacity to convert thermal fluxes in electrical charge and if applied on a "passive" structure they can "actively" reduce the heat overstocking. The electrical charge could be eventually stored for different purposes such as for instance the auto-feeding, or better the energy harvesting. With the reduction of the temperature of each component, and consequently with the reduction of the heat flux that flows through microelectronics, better efficiency and better performances are ensured. In this way the reliability is increased and the goals of the mission could be achieved easier and easier. In this paper the design of a thermal rig made up of pyroelectric devices and dummy electronics components in order to verify the thermo-electric conversion is presented. Furthermore an experimental campaign has been performed to validate the technology here introduced and the relevant results presented. In particular the characterisation of a typical aerospace pyroelectric

  17. Design of process cell equipment layout and its associated piping in typical nuclear fuel reprocessing plant

    International Nuclear Information System (INIS)

    Nuclear fuel reprocessing plant processes spent nuclear fuel discharged from the nuclear reactor to separate chemically the uranium and plutonium. Spent nuclear fuel emits radiation due to the presence of fission products, actinides and activation products. The major operation steps in reprocessing plant are dismantling of spent fuel subassemblies, chopping of fuel pins and dissolution in concentrated nitric acid. Subsequently, this solution containing uranium and plutonium, fission products and actinides is subjected to solvent extraction with tributyl phosphate in diluent as solvent for separating uranium and plutonium from fission products and other actinides. In the design of a fuel reprocessing plant, apart from problems associated with conventional chemical process industries such as corrosion, materials handling, industrial and fire safety and economy, specific considerations such as health hazards from radioactivity (radiological safety) and damage to material by radiation are considered. This necessitates the processing of spent fuel inside the shielded process cells (concrete and lead cells) with remote operation and maintenance philosophy to prevent the contamination as well as radiation exposure to the operators and prevention of criticality in process tanks and equipments. Reprocessing plant consists of number of shielded process cells depending on the processing capacity and type of spent fuel handled. Concrete cells and lead cells houses various type of storage tanks, equipments, liquid transfer devices, etc with interconnecting small bore pipe lines for liquid transfer and supply of services, which runs in multiple layers, forming a high density piping inside the cells. In addition to this, cells have remote handling systems and gadgets for remote operation and maintenance wherever required. This paper highlights the design of process cells, its equipment layout and piping in typical reprocessing plant; the suitable material of construction

  18. Design and Experiment on Self-propelled Precise Feeding Equipment for Dairy Cow

    Directory of Open Access Journals (Sweden)

    Hewei Meng

    2013-04-01

    Full Text Available Designed a kind of self-propelled precise feeding machine for single dairy cow based on the technology of RFID, to achieve the automation,fine and intelligent of dairy farming.The computer was used as the information management platform, MCU was used as control platform, even using wireless transmission, RFID recognition, infrared detection technology and so on, which achievement the information data of wireless transmission,precise recognition and detection cattle position.It is applied to equal-diameter and variable-pitch screw feeding structure to realize the precise concentrated feed supply, equipment performance test shown that the system speed 60rpm is the most stable when feeding, feeding accuracy not less than 97.5%, to meet the feeding requirements, equipped with the best traveling speed is 0.6m/s, the response time of the system is 0.4s, the recognition rate is 96%; through one-month feeding experiment in the dairy cow farm showed that the milk production was increased, the average daily milk yield of individual cows improve 0.8kg than artificial feeding.

  19. Development of the graphic design and control system based on a graphic simulator for the spent fuel dismantling equipment

    International Nuclear Information System (INIS)

    In this study, the graphic design system is developed for designing the spent fuel rod consolidation and the dismantling processes. This system is used throughout the design stages from the conceptual design to the motion analysis. Also, the real-time control system of the rod extracting equipment is developed. This system utilizes the graphic simulator which simulates the motion of the equipment in real time by synchronously connecting the control PC with the graphic server through the TCP/IP network. The developed system is expected to be used as an effective tool in designing the process equipment for the spent fuel management. And the real-time graphic control system can be effectively used to enhance the reliability and safety of the spent fuel handling process by providing the remote monitoring function of the process

  20. Development of the graphic design and control system based on a graphic simulator for the spent fuel dismantling equipment

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J. Y.; Kim, S. H.; Song, T. G.; Yoon, J. S

    2000-06-01

    In this study, the graphic design system is developed for designing the spent fuel rod consolidation and the dismantling processes. This system is used throughout the design stages from the conceptual design to the motion analysis. Also, the real-time control system of the rod extracting equipment is developed. This system utilizes the graphic simulator which simulates the motion of the equipment in real time by synchronously connecting the control PC with the graphic server through the TCP/IP network. The developed system is expected to be used as an effective tool in designing the process equipment for the spent fuel management. And the real-time graphic control system can be effectively used to enhance the reliability and safety of the spent fuel handling process by providing the remote monitoring function of the process.

  1. Design of data acquisition system ZOH production process equipment of ZBS (zircon based sulfate)

    International Nuclear Information System (INIS)

    Design of data acquisition system of ZOH maker unit from ZBS has performed. Design is done as a follow-up of The Design Flow stirred tank reactor (RATB) ZOH Making of ZBS is equipped with a data acquisition system. The design of the system is going to work based on constants or parameters that have been previously calculated. Design method begins with understanding the process description of ZBS ZOH continuous basis, identify the parameters to be observed. Description of the process need to know to determine the actuator is used, as for these parameters are used to determine the sensor to be used. The parameter are the detection of NH4OH and ZBS reserves the feeder tank, flow rate ZBS and NH4OH, the temperature inside RATB, RATB and pH , the produced flow rate of ZOH. Based on the calculation, in order to get the results needed ZOH ZBS will flow into the reactor at the rate of 10 ml/min simultaneously with NH4OH with discharge flow 6.1 ml/min into the RATB 3 liters volume. When the volume reaches half tank RATB then start heating is turned on while the constant feed flow. Conditions of pH and temperature on the RATB always monitored by setting point pH at 10 while setting point temperature of 90°C. Monitoring parameters require gauge/transducer or a particular sensor. The study on the obtained results in the form of a flow chart design controller when controlling the process, when read and transmit data, and display the resulting data acquisition process parameters on the screen according to the parameters that was planned. (author)

  2. Application of PSA in Designing New Third-Generation NPPs Equipped with VVE Reactors

    International Nuclear Information System (INIS)

    The projects of new third-generation NPPs shall meet more stringent safety requirements. A proper balance between a high level of safety and modern requirements for power unit availability indicators cannot be achieved without applying a probabilistic approach in the course of designing, central to which is probabilistic safety assessment (PSA). The report presents the main results from application of PSA in working out new projects of NPPs equipped with VVER reactors, as well as the obtained quantitative results reflecting the entire spectrum of operational states and initiating events. It is shown that by using an efficient combination of active and passive safety systems it is possible to achieve a safety level in the projects complying with the latest requirements, including those following from the lessons learnt from the Fukushima accident. (author)

  3. Design of control system for CSRe cooling equipment based on P2P technology

    International Nuclear Information System (INIS)

    In the HIRFL-CSR project, it needs the high performance requirement in real time and reliability for the control system of CSRe's cooling equipment-Cooler. Simultaneously, the running environment of the Cooler is very complex and it is difficult to predict various kinds of interference. To solve these problems, we focus on the improvement on the control system of the Cooler. The high performance FPGA and ARM embedded systems are used to realize the beam commissioning automatically, and the P2P (Peer to peer) technology and the neural network algorithm are adopted to implement the automatic control of the Cooler. The system provides the advanced hardware platform and the design proposal for the cooling control system. (authors)

  4. The Design and Development of Divertor Remote Handling Equipment for ITER

    International Nuclear Information System (INIS)

    A key ITER maintenance activity is the complete exchange of the divertor system at scheduled intervals, typically after every 3-4 years of plasma operations. In view of this, ITER divertor maintenance is classified as an RH Class 1 activity and as such, detailed design of the associated RH equipment and verification of its operation before ITER construction by way of prototypes and mock-ups, is considered an essential activity. Throughout the course of the ITER design activities one of the major focuses of the EU contribution has been the study and development of remote handling equipment (RHE) necessary for divertor exchange. This suite of RHE will include a number of heavy in-vessel robotic transporters (known as '' ssette movers ''), ex-vessel transfer casks and several general purpose dextrous manipulators used to deploy and operate task-specific RH tooling. The current major step in the divertor RH development programme for ITER involves the construction of a full scale physical test facility in which to demonstrate and refine RHE designs through the operation of prototypes closely replicating those proposed for ITER. This facility, designated the '' Divertor Test Platform 2 (DTP2) '', will be constructed in Tampere, Finland and operated by the Finnish Fusion Association, TEKES. Four separate procurement contracts are currently being executed within European Industry for the supply of the major DTP2 sub-systems namely, a mock-up of the ITER divertor region, a mock-up cassette, a prototype cassette mover and the mover control hardware. The control system software development is being carried out in parallel by staff of the DTP2 host organisation. These DTP2 sub-systems will be brought together in Tampere during the Autumn 2006 / Spring 2007 and the system is expected to be ready for RH trials on the second cassette handling process in the summer of that year. Measures to extend the facility in subsequent years to allow more extensive trials in a 30 degree

  5. GroPBS: Fast Solver for Implicit Electrostatics of Biomolecules

    OpenAIRE

    Bertelshofer, Franziska; Sun, Liping; Greiner, Günther; Böckmann, Rainer A.

    2015-01-01

    Knowledge about the electrostatic potential on the surface of biomolecules or biomembranes under physiological conditions is an important step in the attempt to characterize the physico-chemical properties of these molecules and, in particular, also their interactions with each other. Additionally, knowledge about solution electrostatics may also guide the design of molecules with specified properties. However, explicit water models come at a high computational cost, rendering them unsuitable...

  6. An approach to human-centered design of nuclear medical equipment: the system of caption of the thyroid

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Isaac J.A. Luquetti; Silva, Carlos Borges da; Santana, Marcos; Carvalho, Paulo Victor R.; Oliveira, Mauro Vitor de; Mol, Antonio Carlos Mol; Grecco, Claudio Henrique; Augusto, Silas Cordeiro [Instituto de Engenharia Nuclear (IEN) , Rio de Janeiro, RJ (Brazil)]. E-mail: luquetti@ien.gov.br; borges@ien.gov.br; msantana@ien.gov.br; paulov@ien.gov.br; mvitor@ien.gov.br; mol@ien.gov.br; grecco@ien.gov.br; silas@ien.gov.br

    2005-07-01

    Technology plays an important role in modern medical centers, making health care increasingly complex, relying on complex technical equipment. This technical complexity is particularly noticeable in the nuclear medicine and can increase the risks for human error. Human error has many causes such as performance shaping factors, organizational factors and user interface design. Poorly design human system interfaces of nuclear medical equipment can increase the risks for human error. If all nuclear medical equipment had been designed with good user interfaces, incidents and accidents could be reduced as well as he time required to learn how to use the equipment. Although some manufacturers of nuclear medical equipment have already integrate human factors principles in their products, there is still a need to steer the development of nuclear medical technology toward more human-centered approach. The aim of this paper is to propose a methodology that contributes to the design, development and evaluation of nuclear medical equipment and human system interface, towards a human-centered approach. This methodology includes the ergonomic approach, based on the operator activity analysis, together with human factors standards and guidelines, questionnaires and user based testing. We describe a case study in which this methodology is being applied in evaluation of the thyroid uptake system, getting essential information and data, that ill be used in development of a new system. (author)

  7. An approach to human-centered design of nuclear medical equipment: the system of caption of the thyroid

    International Nuclear Information System (INIS)

    Technology plays an important role in modern medical centers, making health care increasingly complex, relying on complex technical equipment. This technical complexity is particularly noticeable in the nuclear medicine and can increase the risks for human error. Human error has many causes such as performance shaping factors, organizational factors and user interface design. Poorly design human system interfaces of nuclear medical equipment can increase the risks for human error. If all nuclear medical equipment had been designed with good user interfaces, incidents and accidents could be reduced as well as he time required to learn how to use the equipment. Although some manufacturers of nuclear medical equipment have already integrate human factors principles in their products, there is still a need to steer the development of nuclear medical technology toward more human-centered approach. The aim of this paper is to propose a methodology that contributes to the design, development and evaluation of nuclear medical equipment and human system interface, towards a human-centered approach. This methodology includes the ergonomic approach, based on the operator activity analysis, together with human factors standards and guidelines, questionnaires and user based testing. We describe a case study in which this methodology is being applied in evaluation of the thyroid uptake system, getting essential information and data, that ill be used in development of a new system. (author)

  8. Design requirements under development of equipment complex for plastic tubes welding

    International Nuclear Information System (INIS)

    Principles of formation of equipment complex for plastic tube working are determined and its properties are described. A seris of similar mounting portable (transportable) equipment and the main forming units of shop stationary equipment are taken as examples. Ways of improving developments on the basis of suggested principles have been assigned. 4 refs.; 5 figs

  9. Max Tech and Beyond: Maximizing Appliance and Equipment Efficiency by Design

    Energy Technology Data Exchange (ETDEWEB)

    Desroches, Louis-Benoit; Garbesi, Karina

    2011-07-20

    It is well established that energy efficiency is most often the lowest cost approach to reducing national energy use and minimizing carbon emissions. National investments in energy efficiency to date have been highly cost-effective. The cumulative impacts (out to 2050) of residential energy efficiency standards are expected to have a benefit-to-cost ratio of 2.71:1. This project examined energy end-uses in the residential, commercial, and in some cases the industrial sectors. The scope is limited to appliances and equipment, and does not include building materials, building envelopes, and system designs. This scope is consistent with the scope of DOE's appliance standards program, although many products considered here are not currently subject to energy efficiency standards. How much energy could the United States save if the most efficient design options currently feasible were adopted universally? What design features could produce those savings? How would the savings from various technologies compare? With an eye toward identifying promising candidates and strategies for potential energy efficiency standards, the Max Tech and Beyond project aims to answer these questions. The analysis attempts to consolidate, in one document, the energy savings potential and design characteristics of best-on-market products, best-engineered products (i.e., hypothetical products produced using best-on-market components and technologies), and emerging technologies in research & development. As defined here, emerging technologies are fundamentally new and are as yet unproven in the market, although laboratory studies and/or emerging niche applications offer persuasive evidence of major energy-savings potential. The term 'max tech' is used to describe both best-engineered and emerging technologies (whichever appears to offer larger savings). Few best-on-market products currently qualify as max tech, since few apply all available best practices and components. The

  10. Magnetic GMI sensor for detection of biomolecules

    International Nuclear Information System (INIS)

    A magnetic sensor based on the giant magnetoimpedance (GMI) effect for the detection of biomolecules was made with a CoFeSiB amorphous magnetic microwire as sensing element. Using soft ferromagnetic cobalt microparticles and field sensitivities of the impedance of about 2.5%/A m-1 in the very low field region (less than 200 A m-1) at frequencies close to 10 MHz, a highly sensitive response was measured, appropriate for the detection of low biomolecule concentrations

  11. Fabrication and installation of the irradiation equipment design verification test facility

    Energy Technology Data Exchange (ETDEWEB)

    Cho, M. S.; Kang, Y. H.; Kim, B. G. and others

    2000-08-01

    The half-core model with the same configuration as the HANARO reactor, however which the sectional area of the core was cut down half, was developed to test the performance and improve the design of the capsules outside the reactor. The three different materials of aluminium, Zircalloy-4 and SUS304 are used in the HANARO reactor, however, only SUS304 material is used in the test facility because there's no need to consider the effect of neutrons and radiation on it. The 14 sight glasses are installed to view the inside flow and the vibration, and 17 flow receptacles are furnished so that the corresponding flow tubes will be fit in when the half core system will be equipped in the future. The leak tightness was confirmed through the hydraulic pressure test which has the different test pressures of 160kpa and 470kpa at upper and lower part. This test facility can be contributed to the design verification and the performance improvement through the capsule loading test, the hydraulic performance test, the vibration and the endurance test etc.. In addition, this facility can be used on the multi-purpose test such as the drop time test of SO/CA rod after the scheduled drop times, the vibration test of the HANARO fuel and the test of various tools for HANARO operation.

  12. Design, construction and testing of replacement nuclear coolant pump stators to meet today's equipment reliability expectations

    International Nuclear Information System (INIS)

    The reliability expectations of equipment and components in today's nuclear power plant are much greater than three or more decades ago when nuclear plants were first constructed due to economic impact of a failure. Very few components in a pressurized water reactor plant can have as much impact of the plants capacity factor as a catastrophic failure of a reactor coolant pump winding. This paper describes the maintenance approach taken by one North American utility in attempt to preclude such failures. The paper will discuss the challenges of the reactor coolant pump application and the enhancements made in the winding design and construction by the supplier to address failure mechanisms so as to better meet present reliability expectations in accordance with dedicated specifications. The paper will also present the in-process and final testing requirements and limits imposed in an attempt to ensure quality of the machine windings, along with selected test results from the stators that have been designed and constructed to these specifications to date. (author)

  13. Medical equipment and design approach contributing to evolution of heavy-ion radiotherapy

    International Nuclear Information System (INIS)

    As part of the efforts being made to realize high-quality cancer treatment, the Toshiba Group is striving to offer healthcare processes with the advanced heavy-ion radiotherapy system as the core. In addition to key technologies including ion accelerators and irradiation devices developed by Toshiba, Toshiba Medical Systems Corporation has developed an image-guided radiotherapy (IGRT) technology for rapid and highly accurate determination of the beam irradiation position using computer tomography (CT) images taken by an AquilionTM X-ray CT scanner installed in the same treatment room. Moreover, in the area of design, Toshiba has employed a comprehensive approach that considers both optimal operations for the medical personnel and psychological care for the patient in each medical workflow, regarding the various items of equipment as a whole treatment system. In order to realize smooth communication between medical personnel and patients, Toshiba has also applied a design that provides efficiency and comfort appropriate to the treatment status to the displays of the treatment information system. (author)

  14. The theory and effect of solvent environment on biomolecules

    Science.gov (United States)

    Schnieders, Michael J.

    This dissertation describes the theory and effect of solvent environment on biomolecules using a computational model known as a force field. Force fields are based on formulating an efficient, empirical function of atomic coordinates designed to reproduce the potential energy surface predicted by the more rigorous, but also intractably expensive Schrodinger equation. In particular, this work is novel due to use of an Atomic Multipole Optimized Energetics for Biomolecular Applications (AMOEBA) force field that represents charge density using polarizable atomic multipoles. Polarizable Multipole Poisson-Boltzmann (PMPB) and generalized Kirkwood (GK) continuum electrostatics models are described that interact self-consistently with AMOEBA biomolecules. In conjunction with a novel apolar estimator, the PMPB and GK models are used to construct two implicit solvents for solutes represented by the AMOEBA force field. The effect of solvent environment on the electrostatic moments of a large set of folded proteins is examined.

  15. An overview: biomolecules from microalgae for animal feed and aquaculture.

    Science.gov (United States)

    Yaakob, Zahira; Ali, Ehsan; Zainal, Afifi; Mohamad, Masita; Takriff, Mohd Sobri

    2014-12-01

    Despite being more popular for biofuel, microalgae have gained a lot of attention as a source of biomolecules and biomass for feed purposes. Algae farming can be established using land as well as sea and strategies can be designed in order to gain the products of specific interest in the optimal way. A general overview of the contributions of Algae to meet the requirements of nutrients in animal/aquaculture feed is presented in this study. In addition to its applications in animal/aquaculture feed, algae can produce a number of biomolecules including astaxanthin, lutein, beta-carotene, chlorophyll, phycobiliprotein, Polyunsaturated Fatty Acids (PUFAs), beta-1,3-glucan, and pharmaceutical and nutraceutical compounds which have been reviewed with respect to their commercial importance and current status. The review is further extended to highlight the adequate utilization of value added products in the feeds for livestock, poultry and aquaculture (with emphasis in shrimp farming). PMID:25984489

  16. Recent advances in exploiting ionic liquids for biomolecules: Solubility, stability and applications.

    Science.gov (United States)

    Sivapragasam, Magaret; Moniruzzaman, Muhammad; Goto, Masahiro

    2016-08-01

    The technological utility of biomolecules (e.g. proteins, enzymes and DNA) can be significantly enhanced by combining them with ionic liquids (ILs) - potentially attractive "green" and "designer" solvents - rather than using in conventional organic solvents or water. In recent years, ILs have been used as solvents, cosolvents, and reagents for biocatalysis, biotransformation, protein preservation and stabilization, DNA solubilization and stabilization, and other biomolecule-based applications. Using ILs can dramatically enhance the structural and chemical stability of proteins, DNA, and enzymes. This article reviews the recent technological developments of ILs in protein-, enzyme-, and DNA-based applications. We discuss the different routes to increase biomolecule stability and activity in ILs, and the design of biomolecule-friendly ILs that can dissolve biomolecules with minimum alteration to their structure. This information will be helpful to design IL-based processes in biotechnology and the biological sciences that can serve as novel and selective processes for enzymatic reactions, protein and DNA stability, and other biomolecule-based applications. PMID:27312484

  17. WIPP conceptual design report. Addendum J. Support equipment in the high level waste facility of the Waste Isolation Pilot Plant

    International Nuclear Information System (INIS)

    The Aerojet Manufacturing Company (AMCO) received a contract in November 1976 to provide consulting services in assisting Holmes and Narver, Incorporated with the conceptual designs, cost estimates, and schedules of equipment used to handle waste casks, to decontaminate waste canisters and to overpack damaged or highly contaminated waste canisters for the Waste Isolation Pilot Plant (WIPP). Also, the layout of the hot cell in which canister handling, overpack and decontamination takes place was to be reviewed along with the time and motion study of the cell operations. This report has been prepared to present the results of the efforts and contains all technical and planning data developed during the program. The contents of this report are presented in three sections: (1) comments on the existing design criteria, equipment conceptual designs, hot cell design and time and motion studies of projected hot cell activities; (2) design descriptions of the equipment concepts and justification for varying from the existing concept (if a variation occurred). Drawings of each concept are provided in Appendix A. These design descriptions and drawings were used as the basis for the cost estimates; and (3) schedule projections and cost estimates for the equipment described in Section 2. Detail cost estimate backup data is provided in Appendix B

  18. Equipment Design and Cost Estimation for Small Modular Biomass Systems, Synthesis Gas Cleanup, and Oxygen Separation Equipment; Task 1: Cost Estimates of Small Modular Systems

    Energy Technology Data Exchange (ETDEWEB)

    Nexant Inc.

    2006-05-01

    This deliverable is the Final Report for Task 1, Cost Estimates of Small Modular Systems, as part of NREL Award ACO-5-44027, ''Equipment Design and Cost Estimation for Small Modular Biomass Systems, Synthesis Gas Cleanup and Oxygen Separation Equipment''. Subtask 1.1 looked into processes and technologies that have been commercially built at both large and small scales, with three technologies, Fluidized Catalytic Cracking (FCC) of refinery gas oil, Steam Methane Reforming (SMR) of Natural Gas, and Natural Gas Liquids (NGL) Expanders, chosen for further investigation. These technologies were chosen due to their applicability relative to other technologies being considered by NREL for future commercial applications, such as indirect gasification and fluidized bed tar cracking. Research in this subject is driven by an interest in the impact that scaling has on the cost and major process unit designs for commercial technologies. Conclusions from the evaluations performed could be applied to other technologies being considered for modular or skid-mounted applications.

  19. Design challenges for matrix assisted pulsed laser evaporation and infrared resonant laser evaporation equipment

    Science.gov (United States)

    Greer, James A.

    2011-11-01

    Since the development of the Matrix Assisted Pulsed Laser Evaporation (MAPLE) process by the Naval Research Laboratory (NRL) in the late 1990s, MAPLE has become an active area of research for the deposition of a variety of polymer, biological, and organic thin films. As is often the case with advancements in thin-film deposition techniques new technology sometimes evolves by making minor or major adjustments to existing deposition process equipment and techniques. This is usually the quickest and least expensive way to try out new ideas and to "push the envelope" in order to obtain new and unique scientific results as quickly as possible. This process of "tweaking" current equipment usually works to some degree, but once the new process is further refined overall designs for a new deposition tool based on the critical attributes of the new process typically help capitalize more fully on the all the salient features of the new and improved process. This certainly has been true for the MAPLE process. In fact the first MAPLE experiments the polymer/solvent matrix was mixed and poured into a copper holder held at LN2 temperature on a laboratory counter top. The holder was then quickly placed onto a LN2 cooled reservoir in a vacuum deposition chamber and placed in a vertical position on a LN2 cooled stage and pumped down as quickly as possible. If the sample was not placed into the chamber quickly enough the frozen matrix would melt and drip into the bottom of the chamber onto the chambers main gate valve making a bit of a mess. However, skilled and motivated scientists usually worked quickly enough to make this process work most of the time. The initial results from these experiments were encouraging and led to several publications which sparked considerable interest in this newly developed technique Clearly this approach provided the vision that MAPLE was a viable deposition process, but the equipment was not optimal for conducting MAPLE experiments on a regular basis

  20. Manual on safety aspects of the design and equipment of hot laboratories. 1981 ed

    International Nuclear Information System (INIS)

    This manual covers the general principles of planning and design of areas inside laboratories according to the varying potential radiation and contamination hazards; enclosures for radioactive material containment; viewing and lighting systems and various types of manipulators; transfer and transport of radioactive materials within the laboratories; air cleaning and ventilation systems, with particular reference to IAEA Safety Series No.17; techniques for controlling air pollution from the operation of nuclear facilities; various radioactive waste disposal systems; criticality control; fire protection; personnel monitoring, including changing-room monitoring and protective clothing; standardization and automation; and administrative controls. Although alpha, beta, gamma technologies have developed separately, equipment used in radioactive work is common to many operations. There is a step change in technology between work with uranium and plutonium and between work with plutonium and other transuranics; with plutonium one enters the field of alpha, beta, gamma technology. This manual reports the basic requirements and gives reference to more sophisticated techniques available. It is not concerned with work on a commercial scale. Other publications of interest in this context, for instance IAEA Safety Series No.39, are referenced for more detailed information.

  1. Biomolecule-assisted route to prepare titania mesoporous hollow structures.

    Science.gov (United States)

    Ding, Shangjun; Wang, Yaoming; Hong, Zhanglian; Lü, Xujie; Wan, Dongyun; Huang, Fuqiang

    2011-10-01

    Amino acids, as a particularly important type of biomolecules, have been used as multifunctional templates to intelligently construct mesoporous TiO(2) hollow structures through a simple solvothermal reaction. The structure-directing behaviors of various amino acids were systematically investigated, and it was found that these biomolecules possess the general capability to assist mesoporous TiO(2) hollow-sphere formation. At the same time, the nanostructures of the obtained TiO(2) are highly dependent on the isoelectric points (pI) of amino acids. Their molecular-structure variations can lead to pI differences and significantly influence the final TiO(2) morphologies. Higher-pI amino acids (e.g., L-lysine and L-arginine) have better structure-directing abilities to generate nanosheet-assembled hollow spheres and yolk/shell structures. The specific morphologies and mesopore size of these novel hollow structures can also be tuned by adjusting the titanium precursor concentration. Heat treatment in air and vacuum was further conducted to transform the as-prepared structures to porous nanoparticle-assembled hollow TiO(2) and TiO(2)/carbon nanocomposites, which may be potentially applied in the fields of photocatalysts, dye-sensitized solar cells, and Li batteries. This study provides some enlightenment on the design of novel templates by taking advantage of biomolecules. PMID:21882272

  2. The Design of Transportation Equipment in Terms of Human Capabilities. The Role of Engineering Psychology in Transport Safety.

    Science.gov (United States)

    McFarland, Ross A.

    Human factors engineering is considered with regard to the design of safety factors for aviation and highway transportation equipment. Current trends and problem areas are identified for jet air transportation and for highway transportation. Suggested solutions to transportation safety problems are developed by applying the techniques of human…

  3. Development of a bridge transported servo manipulator for the maintenance of the hot cell equipment - a prototype design

    International Nuclear Information System (INIS)

    Mechanical Master - Slave Manipulators (MSMs ) which are mounted on the hot cell wall cannot access all the areas for the equipment maintenance due to their reach limitation. A Bridge Transported Servo Manipulator (BTSM) has been designed to overcome the limitation of access that is a drawback of the MSMs for the equipment maintenance. The BTSM system consists of four components : a transporter with a telescoping tubeset , a slave manipulator, a master manipulator, and a remote control system. T he BTSM system has been designed by Solid Edge which is a 3D CAD, except for the remote control system. In this paper, it is addressed the design and analysis of the mechanical parts, except for the design of the remote control system

  4. SECOND GENERATION EXPERIMENTAL EQUIPMENT DESIGN TO SUPPORT VOLOXIDATION TESTING AT INL

    International Nuclear Information System (INIS)

    Voloxidation is a potential head-end process used prior to aqueous or pyrochemical spent-oxide-fuel treatment. The spent oxide fuel is heated to an elevated temperature in oxygen or air to promote separation of the fuel from the cladding as well as volatize the fission products. The Idaho National Laboratory (INL) and the Korea Atomic Energy Research Institute (KAERI) have been collaborating on voloxidation research through a joint International Nuclear Energy Research Initiative (I-NERI). A new furnace and off-gas trapping system (OTS) with enhanced capability was necessary to perform further testing. The design criteria for the OTS were jointly agreed upon by INL and KAERI. First, the equipment must accommodate the use of spent nuclear fuel and be capable of operating in the Hot Fuel Examination Facility (HFEF) at the INL. This primarily means the furnace and OTS must be remotely operational and maintainable. The system requires special filters and distinctive temperature zones so that the fission products can be uniquely captured. The OTS must be sealed to maximize the amount of fission products captured. Finally, to accommodate the largest range of operating conditions, the OTS must be capable of handling high temperatures and various oxidizing environments. The constructed system utilizes a vertical split-tube furnace with four independently controlled zones. One zone is capable of reaching 1200 C to promote the release of volatile fission products. The three additional zones that capture fission products can be controlled to operate between 100-1100 C. A detailed description of the OTS will be presented as well as some initial background information on high temperature seal options

  5. Improved design of electrophoretic equipment for rapid sickle-cell-anemia screening

    Science.gov (United States)

    Reddick, J. M.; Hirsch, I.

    1974-01-01

    Effective mass screening may be accomplished by modifying existing electrophoretic equipment in conjunction with multisample applicator used with cellulose-acetate-matrix test paper. Using this method, approximately 20 to 25 samples can undergo electrophoresis in 5 to 6 minutes.

  6. Using Some Coupled Numerical Models in Problems of Designing an Inductive Electrothermal Equipment

    Directory of Open Access Journals (Sweden)

    LEUCA Teodor

    2014-05-01

    Full Text Available This paper focuses on the numerical modeling of coupling the electromagnetic and the thermal field, in the process of inductive heating, for inductive electrothermal equipments. Numerical results are carried out by using a FLUX2D application.

  7. Microorganisms and biomolecules in space hard environment

    Science.gov (United States)

    Horneck, G.

    1981-01-01

    Microorganisms and biomolecules exposed to space vacuum and to different intensities of selected wavelengths of solar ultraviolet radiation is studied. The influence of these factors, applied singly or simultaneously, on the integrity of microbial systems and biomolecules is measured. Specifically, this experiment will study in Bacillus subtilis spores (1) disturbances in subsequent germination, outgrowth, and colony formation; (2) photochemical reactions of the DNA and protein in vivo and in vitro and their role in biological injury; and (3) the efficiency of repair processes in these events.

  8. Sixth international conference on material issues in design, manufacturing and operation of nuclear power plants equipment. Collection of abstracts

    International Nuclear Information System (INIS)

    The Collection of Abstracts of the sixth international conference On material issues in design, manufacturing and operation of nuclear power plants equipment are presented. The main attention is paid to the issue of structural integrity with an emphasis on the irradiation of WWER reactor pressure vessels. The questions concerning materials development and their production, properties study, structure integrity assessment of WWER reactor pressure vessels, lifetime of austenitic pipelines and equipment during operation and also manufacture of containers for transportation and prolonged storage of spent fuel are discussed

  9. Remote maintenance systems requirements are being developed to provide design guidelines for machine components, to define maintenance interfaces, and to quantify maintenance equipment and procedures needed

    International Nuclear Information System (INIS)

    Remote maintenance systems requirements are being developed to provide design guidelines for machine components, to define maintenance interfaces, and to quantify maintenance equipment and procedures needed

  10. Simple approach to study biomolecule adsorption in polymeric microfluidic channels

    International Nuclear Information System (INIS)

    Highlights: ► A simple tool to assess biomolecule adsorption onto the surfaces of microchannels. ► Development for dilution by surface-adsorption based depletion of protein samples. ► It can easily be done using a readily available apparatus like a spin-coater. ► The assessment tool is facile and quantitative. ► Straightforward comparison of different surface chemistries. - Abstract: Herein a simple analytical method is presented for the characterization of biomolecule adsorption on cyclo olefin polymer (COP, trade name: Zeonor®) substrates which are widely used in microfluidic lab-on-a-chip devices. These Zeonor® substrates do not possess native functional groups for specific reactions with biomolecules. Therefore, depending on the application, such substrates must be functionalized by surface chemistry methods to either enhance or suppress biomolecular adsorption. This work demonstrates a microfluidic method for evaluating the adsorption of antibodies and oligonucleotides surfaces. The method uses centrifugal microfluidic flow-through chips and can easily be implemented using common equipment such as a spin coater. The working principle is very simple. The user adds 40 L of the solution containing the sample to the starting side of a microfluidic channel, where it is moved through by centrifugal force. Some molecules are adsorbed in the channel. The sample is then collected at the other end in a small reservoir and the biomolecule concentration is measured. As a pilot application, we characterized the adsorption of goat anti-human IgG and a 20-mer DNA on Zeonor®, and on three types of functionalized Zeonor: 3-aminopropyltriethoxysilane (APTES) modified surface with mainly positive charge, negatively charged surface with immobilized bovine serum albumin (BSA), and neutral, hydrogel-like film with polyethylene glycol (PEG) characteristics. This simple analytical approach adds to the fundamental understanding of the interaction forces in real

  11. Portable Kitchen Equipment Design Research%可携带式厨房设备设计研究

    Institute of Scientific and Technical Information of China (English)

    泮娇娇; 周晓江

    2013-01-01

    Life habits of university graduate groups is discussed and analyzed. From the aspects of different function to the design of portable kitchen equipment requirements to explore. Preliminary design of portable kitchen equipment are given, and the main study crowd portable kitchen design of research and discussion.%主要对大学刚毕业人群的生活习惯做了探讨和分析。从不同功能方面对可携带式厨房设备的设计要求作出探讨。对实现可携带式厨房设备作出初步构想,并且作了主要针对人群可携带式厨房设计研究的课题研究和探讨。

  12. Tuneable graphene nanopores for single biomolecule detection.

    Science.gov (United States)

    Al-Dirini, Feras; Mohammed, Mahmood A; Hossain, Md Sharafat; Hossain, Faruque M; Nirmalathas, Ampalavanapillai; Skafidas, Efstratios

    2016-05-21

    Solid-state nanopores are promising candidates for next generation DNA and protein sequencing. However, once fabricated, such devices lack tuneability, which greatly restricts their biosensing capabilities. Here we propose a new class of solid-state graphene-based nanopore devices that exhibit a unique capability of self-tuneability, which is used to control their conductance, tuning it to levels comparable to the changes caused by the translocation of a single biomolecule, and hence, enabling high detection sensitivities. Our presented quantum simulation results suggest that the smallest amino acid, glycine, when present in water and in an aqueous saline solution can be detected with high sensitivity, up to a 90% change in conductance. Our results also suggest that passivating the device with nitrogen, making it an n-type device, greatly enhances its sensitivity, and makes it highly sensitive to not only the translocation of a single biomolecule, but more interestingly to intramolecular electrostatics within the biomolecule. Sensitive detection of the carboxyl group within the glycine molecule, which carries a charge equivalent to a single electron, is achieved with a conductance change that reaches as high as 99% when present in an aqueous saline solution. The presented findings suggest that tuneable graphene nanopores, with their capability of probing intramolecular electrostatics, could pave the way towards a new generation of single biomolecule detection devices. PMID:27171594

  13. Tuneable graphene nanopores for single biomolecule detection

    Science.gov (United States)

    Al-Dirini, Feras; Mohammed, Mahmood A.; Hossain, Md Sharafat; Hossain, Faruque M.; Nirmalathas, Ampalavanapillai; Skafidas, Efstratios

    2016-05-01

    Solid-state nanopores are promising candidates for next generation DNA and protein sequencing. However, once fabricated, such devices lack tuneability, which greatly restricts their biosensing capabilities. Here we propose a new class of solid-state graphene-based nanopore devices that exhibit a unique capability of self-tuneability, which is used to control their conductance, tuning it to levels comparable to the changes caused by the translocation of a single biomolecule, and hence, enabling high detection sensitivities. Our presented quantum simulation results suggest that the smallest amino acid, glycine, when present in water and in an aqueous saline solution can be detected with high sensitivity, up to a 90% change in conductance. Our results also suggest that passivating the device with nitrogen, making it an n-type device, greatly enhances its sensitivity, and makes it highly sensitive to not only the translocation of a single biomolecule, but more interestingly to intramolecular electrostatics within the biomolecule. Sensitive detection of the carboxyl group within the glycine molecule, which carries a charge equivalent to a single electron, is achieved with a conductance change that reaches as high as 99% when present in an aqueous saline solution. The presented findings suggest that tuneable graphene nanopores, with their capability of probing intramolecular electrostatics, could pave the way towards a new generation of single biomolecule detection devices.

  14. Immobilizing Biomolecules Near the Diffraction Limit

    DEFF Research Database (Denmark)

    Skovsen, Esben; Petersen, Maria Teresa Neves; Gennaro, Ane Kold Di;

    2009-01-01

    Our group has previously shown that biomolecules containing disulfide bridges in close proximity to aromatic residues can be immobilized, through covalent bonds, onto thiol derivatized surfaces upon UV excitation of the aromatic residue(s). We have also previously shown that our new technology ca...

  15. PREFACE: Structure and Function of Biomolecules

    Science.gov (United States)

    Cieplak, Marek; Sienkiewicz, Andrzej

    2005-05-01

    The Workshop on the Structure and Function of Biomolecules took place in Bedlewo near Poznan, Poland, on 13-15 May 2004, two weeks after Poland joined the European Community. The Workshop was sponsored by the ASPECT Centre of Excellence for Advanced Spectroscopy Applications in Physics, Modern Science, Biology and Environmental Protection (the European Community contract GMA1-2002-72801) and by the Institute of Physics, Polish Academy of Sciences. The Workshop gathered together approximately 100 participants mostly from the European Community but also from Canada, Russia, Switzerland, Turkey and the USA. The scientific aim of this Workshop was to provide an active forum for cross-disciplinary interactions between specialists who are active in different fields related to biomolecules, with an emphasis on proteins and nucleic acids. The workshop covered both experimental and theoretical issues. The subjects that were discussed included: mechanical stretching of biomolecules, protein kinetics and structure, aggregation of biomolecules, and novel spectroscopic methods for studying protein conformation. There were 36 invited lectures and 33 poster contributions presented at the Workshop. This Special Issue of Journal of Physics: Condensed Matter contains a sample of the research presented at the Workshop.

  16. A Multidisciplinary, Open Access Platform for Research on Biomolecules

    Directory of Open Access Journals (Sweden)

    Jürg Bähler

    2011-08-01

    Full Text Available I am pleased to introduce Biomolecules, a new journal to report on all aspects of science that focuses on biologically derived substances, from small molecules to complex polymers. Some examples are lipids, carbohydrates, vitamins, hormones, amino acids, nucleotides, peptides, RNA and polysaccharides, but this list is far from exhaustive. Research on biomolecules encompasses multiple fascinating questions. How are biomolecules synthesized and modified? What are their structures and interactions with other biomolecules? How do biomolecules function in biological processes, at the level of organelles, cells, organs, organisms, or even ecosystems? How do biomolecules affect either the organism that produces them or other organisms of the same or different species? How are biomolecules shaped by evolution, and how in turn do they affect cellular phenotypes? What is the systems-level contribution of biomolecules to biological function?

  17. Ionic strength independence of charge distributions in solvation of biomolecules

    OpenAIRE

    Virtanen, J. J.; Sosnick, T. R.; Freed, K. F.

    2014-01-01

    Electrostatic forces enormously impact the structure, interactions, and function of biomolecules. We perform all-atom molecular dynamics simulations for 5 proteins and 5 RNAs to determine the dependence on ionic strength of the ion and water charge distributions surrounding the biomolecules, as well as the contributions of ions to the electrostatic free energy of interaction between the biomolecule and the surrounding salt solution (for a total of 40 different biomolecule/solvent combinations...

  18. Impact of Mars sand on dust on the design of space suits and life support equipment: A technology assessment

    Science.gov (United States)

    Simonds, Charles H.

    1991-01-01

    Space suits and life support equipment will come in intimate contact with Martian soil as aerosols, wind blown particles and material thrown up by men and equipment on the Martian surface. For purposes of this discussion the soil is assumed to consist of a mixture of cominuted feldspar, pyroxene, olivine, quartz, titanomagnetite and other anhydrous and hydrous iron bearing oxides, clay minerals, scapolite and water soluble chlorides and sulfates. The soil may have photoactivated surfaces that acts as a strong oxidizer with behavior similar to hydrogen peroxide. The existing data about the Mars soil suggests that the dust and sand will require designs analogous to those uses on equipment exposed to salty air and blowing sand and dust. The major design challenges are in developing high performance radiators which can be cleaned after each EVA without degradation, designing seals that are readily cleaned and possibly in selecting materials which will not be degraded by any strong oxidants in the soil. The magnitude of the dust filtration challenge needs careful evaluation in terms of the trade off between fine-particle dust filters with low pressure drop that are either physically large and heavy, like filter baghouses require frequent replacement of filter elements, of low volume high pressure thus power consumption approaches, or washable filters. In the latter, filter elements are cleaned with water, as could the outsides of the space suits in the airlock.

  19. New and improved designs of surface mining equipment and machine parts for efficient mining and haulage in the mining industry and in soil engineering

    Energy Technology Data Exchange (ETDEWEB)

    Kluge, H.; Reinel, H. (VEB SMK TAKRAF (German Democratic Republic). Georgi-Dimitroff-Werk)

    1989-01-01

    Explains specifications and design of mining equipment series produced by the TAKRAF manufacturer, GDR for coal and mineral surface mines. Equipment includes SRs bucket wheel excavators, ERs bucket chain excavators and BRs mobile transfer conveyors. Various photographs are provided. Small sized equipment is available for selective mining of sections in larger mines as well as for operation in small mines with mine production of 150 to 300 thousand m{sup 3}. Another focus is equipment for direct spoil overcast by a combination of bucket wheel or bucket chain excavator, mobile conveyor and spoil spreader. Recently developed equipment, its production capacity and size are presented.

  20. Design and Application of an Expert System for Equipment Maintenance and Forecast

    Institute of Scientific and Technical Information of China (English)

    WANG Jian; PAN Kai-long; SHEN Yun-feng; LI Jie

    2007-01-01

    The maintenance and forecast expert system of equipment based on Artificial Neural Network is composed of control, measure, failure forecast, execution, data processing module and database. The data processing module obtains the change of the controlled objects′ structure and parameters, then takes correspondent measures according to the examination and diagnosis information. The failure forecast module finds the control system fault, separates the fault symptom location, tells the fault kind, estimates the magnitude and time of the fault, and finally makes evaluation and decision.

  1. An Expert System for Supporting the Design and Selection of Mechanical Equipment for Recreational Crafts

    OpenAIRE

    T. Gonciarz

    2014-01-01

    Expert Systems can be defined as computer programs, whose main task is to simulate a human expert, usually in a narrow field of expertise. Expert Systems have experienced tremendous growth and popularity since their commercial introduction in the early 1970’s. Today, Expert Systems are used in business, science, engineering, manufacturing and other engineering applications such as planning, scheduling, diagnosing equipment failures and are used in almost every stage of the manufacturing proce...

  2. Natural Antioxidants: Fascinating or Mythical Biomolecules?

    Directory of Open Access Journals (Sweden)

    Johannes Van Staden

    2010-10-01

    Full Text Available Research on the use, properties, characteristics and sources of antioxidants especially phenolic compounds, flavonoids, vitamins, synthetic chemicals and some micronutrients began in the late 18th century. Since then antioxidant research has received considerable attention and over a hundred thousand papers have been published on the subject. This has led to a rampant use of antioxidants in order to try to obtain and preserve optimal health. A number of nutraceuticals and food supplements are frequently fortified with synthetic or natural antioxidants. However, some research outcomes have led to the belief that antioxidants exist as mythical biomolecules. This review provides a critical evaluation of some common in vitro antioxidant capacity methods, and a discussion on the role and controversies surrounding non-enzymatic biomolecules, in particular phenolic compounds and non-phenolic compounds, in oxidative processes in an attempt of stemming the tidal wave that is threatening to swamp the concept of natural antioxidants.

  3. Quantum dots and their interaction with biomolecules

    OpenAIRE

    Stanisavljević, Maja

    2015-01-01

    In this study CdTe QDs were synthetized via microwave irradiation method. Further they have been modified for purposes of their interaction with biomolecules using different conjugation approaches. Applied conjugation chemistries were non-specific interaction, streptavidin-biotin affinity. Glutathione modified CdTe QDs of 2 nm size were capable of non-specific interaction with major groove of DNA, while streptavidin modified CdTe QDs served as specific linker for biotinylated oligonucleotides...

  4. Immobilizing Biomolecules Near the Diffraction Limit

    DEFF Research Database (Denmark)

    Skovsen, Esben; Neves-Petersen, Maria Teresa; Kold, Ane;

    2009-01-01

    Our group has previously shown that biomolecules containing disulfide bridges in close proximity to aromatic residues can be immobilized, through covalent bonds, onto thiol derivatized surfaces upon UV excitation of the aromatic residue(s). We have also previously shown that our new technology ca...... a substrate, which can be generated by a UV diffraction pattern. Such patterns can have sub-micron feature sizes and could therefore be of great relevance for present and future nanotechnological applications....

  5. Separation of biomolecules using supercritical fluid extraction.

    Science.gov (United States)

    Lucien, F P; Liong, K K; Cotton, N J; Macnaughton, S J; Foster, N R

    1993-01-01

    Supercritical fluids are increasingly being used as a replacement for more conventional organic solvents in the extraction of biomolecules from a range of matrices. Supercritical fluid extraction of essential fatty acids from fish oils is discussed. Supercritical CO2 was used to fractionate two fatty acids, EPA and DHA from fish oil ethyl esters. EPA and DHA were obtained with a purity of 58% and 67% respectively from Sardine oil with an original composition of 17% and 12%. PMID:7763846

  6. Of Tangerines, Asparagus, and Nonprotein Biomolecules.

    Science.gov (United States)

    2016-05-19

    Every month the editors of Cell Chemical Biology bring you highlights of the most recent chemical biology literature. Our May 2016 selection includes a new method for labeling and visualizing nonprotein biomolecules using electron microscopy; a small molecule, originally found in tangerine peel, that regulates our circadian clock and helps with some of the metabolic pathologies associated with circadian rhythms; and a finding that asparagine is used as an amino acid exchanger in tumor cells. PMID:27203369

  7. Solar Equipment

    Science.gov (United States)

    1983-01-01

    A medical refrigeration and a water pump both powered by solar cells that convert sunlight directly into electricity are among the line of solar powered equipment manufactured by IUS (Independent Utility Systems) for use in areas where conventional power is not available. IUS benefited from NASA technology incorporated in the solar panel design and from assistance provided by Kerr Industrial Applications Center.

  8. The design of an energy harvesting device for prolonging the working time of DC equipment

    Science.gov (United States)

    Wen, Yayuan; Deng, Huaxia; Zhang, Jin; Yu, Liandong

    2016-01-01

    Energy harvesting (EH) derives from the idea of converting the ambient energy into electric energy, which can solve the problem of DC supply for some electronic equipment. PZT is a typical piezoelectric material of inorganic, which has been developed as EH devices to transfer ambient vibration energy into electric energy. However, these PZT devices require relatively violent excitation, and easy to be fatigue fracture under the resonance condition. In this paper, PVDF, which is a kind of soft piezoelectric polymer, is adopted for developing transducer. The PVDF devices are flexible and have longer life time than PZT devices under the harmonic environment. The EH researches are mainly focused on the development of energy transfer efficiency either by the mechanical structure of transducer or the improvement of circuit. However, the practicality and stability of the EH devices are important in the practical engineering applications. In this paper, a charge amplifier is introduced in the circuit in order to guarantee the stability of the battery charging under small ambient vibration conditions. The model of the mechanical structure of PVDF and the electric performance of circuit are developed. The experimental results and simulation show that the stability of battery charging is improved and the working time of DC equipment is prolonged.

  9. The design of equipment for optical power measurement in FSO link beam cross-section

    Science.gov (United States)

    Latal, Jan; David, Tomas; Wilfert, Otakar; Kolka, Zdenek; Koudelka, Petr; Hanacek, Frantisek; Vitasek, Jan; Siska, Petr; Skapa, Jan; Vasinek, Vladimir

    2012-06-01

    The free space optical links have found their major application in today's technological society. The demand for quality broadband is a must for all types of end users in these times. Because of the large jamming from wireless radio networks in non-licensed ISM bands, the free space optical links provide bridging of some densely populated urban areas. Their advantage is the high transmission rate for relatively long distances. However, the disadvantage is the dependence of free space optical links on atmospheric influences. Aired collimated optical beam passes through the atmospheric transmission environment and by its influence cause the deformation of the optical beam. Author's team decided to construct a special measuring device for measurement of optical power in FSO link beam cross-section. The equipment is mobile and can be rearranged and adjust according to the given location and placement of the FSO link at any time. The article describes the individual structural elements of the measuring equipment, its controlling and application for evaluation and adjustment of measuring steps. The graphs from optical power measurements in the beam cross-section of professional FSO links are presented at the end.

  10. An aptamer-functionalized chemomechanically modulated biomolecule catch-and-release system

    Science.gov (United States)

    Shastri, Ankita; McGregor, Lynn M.; Liu, Ya; Harris, Valerie; Nan, Hanqing; Mujica, Maritza; Vasquez, Yolanda; Bhattacharya, Amitabh; Ma, Yongting; Aizenberg, Michael; Kuksenok, Olga; Balazs, Anna C.; Aizenberg, Joanna; He, Ximin

    2015-05-01

    The efficient extraction of (bio)molecules from fluid mixtures is vital for applications ranging from target characterization in (bio)chemistry to environmental analysis and biomedical diagnostics. Inspired by biological processes that seamlessly synchronize the capture, transport and release of biomolecules, we designed a robust chemomechanical sorting system capable of the concerted catch and release of target biomolecules from a solution mixture. The hybrid system is composed of target-specific, reversible binding sites attached to microscopic fins embedded in a responsive hydrogel that moves the cargo between two chemically distinct environments. To demonstrate the utility of the system, we focus on the effective separation of thrombin by synchronizing the pH-dependent binding strength of a thrombin-specific aptamer with volume changes of the pH-responsive hydrogel in a biphasic microfluidic regime, and show a non-destructive separation that has a quantitative sorting efficiency, as well as the system's stability and amenability to multiple solution recycling.

  11. Immobilization of Biomolecules on Poly(vinyldimethylazlactone)-containing Surface Scaffolds

    Energy Technology Data Exchange (ETDEWEB)

    Barrninger, Joshua [Clemson University; Messman, Jamie M [ORNL; Banaszak, Abigail [Clemson University; Meyer III, Harry M [ORNL; Kilbey, II, S Michael [ORNL

    2009-01-01

    We describe the successful development of a procedure for the step-by-step formation of a reactive, multi-layer polymer scaffold incorporating polymers based on 2-vinyl-4,4-dimethylazlactone (VDMA) on a silicon wafer and the characterization of these materials. Also discussed is the development of a procedure for the non-site specific attachment of a biomolecule to the modified silicon wafer, including scaffolds modified via drop-on-demand (DOD) inkjet printing. VDMA-based polymers were used because of their hydrolytic stability and ability of the pendant azlactone rings to form stable covalent bonds with primary amines without byproducts via nucleophilic addition. This reaction proceeds without a catalyst and at room temperature, yielding a stable amide linkage, which adds to the ease of construction expected when using VDMA-based polymers. DOD inkjet printing was explored as an interesting method for creating surfaces with one or more patterns of biomolecules, because of the flexibility and ease in pattern design.

  12. Chitosan membrane development and design of equipment for the removal of heavy metals from water

    International Nuclear Information System (INIS)

    A filtration technique has compared with 1,75% m/v chitosan membranes, crosslinked with glutaraldehyde (0,08% m/v) and without cross link, to quantify the removal capacity of chromium, copper and cadmium ions of model solutions. In addition, a simple and low cost equipment was developed to use with prepared membranes. The main goal has been to use biodegradable materials for removing heavy metals from water, through a low energy consumption, cheap, and applicable to specific problems. Two data sheets were prepared for the membranes and was found that chromium was the metal with the highest removal from water, by using a crosslinked membrane. Metal adsorption was best adjusted to the Freundlich isotherm model, better than Langmuir isotherm model. However, no correlation has been found between pore size of the membranes and crosslinking degree. (author)

  13. Design and Operation of Equipment to Detect and Remove Water within Used Nuclear Fuel Storage Bottles

    Energy Technology Data Exchange (ETDEWEB)

    C.C. Baker; T.M. Pfeiffer; J.C. Price

    2013-09-01

    Inspection and drying equipment has been implemented in a hot cell to address the inadvertent ingress of water into used nuclear fuel storage bottles. Operated with telemanipulators, the system holds up to two fuel bottles and allows their threaded openings to be connected to pressure transducers and a vacuum pump. A prescribed pressure rebound test is used to diagnose the presence of moisture. Bottles found to contain moisture are dried by vaporization. The drying process is accelerated by the application of heat and vacuum. These techniques detect and remove virtually all free water (even water contained in a debris bed) while leaving behind most, if not all, particulates. The extracted water vapour passes through a thermoelectric cooler where it is condensed back to the liquid phase for collection. Fuel bottles are verified to be dry by passing the pressure rebound test.

  14. Progress of R and D and design of blanket remote handling equipment for ITER

    International Nuclear Information System (INIS)

    The design of in-vessel transporter (IVT) including vehicle manipulator has been updated according to the design changes such as blanket segmentation and structure, taking account of the interface between modules and vehicle manipulator. In particular, the updated design of the vehicle manipulator and rail has been carried out because of collision avoidance between modules and vehicle manipulator. According to the updated design, the vehicle manipulator has been reduced by about 30% in weight, compared with the reference design. In parallel with design activities, the R and D to clarify the specifications of the IVT design in detail is also performed, i.e., simulation system to provide the visual information during maintenance, dry lubricant to prevent the lubricant oil from spreading in the vacuum vessel (VV). The rail connection and cable handling in the transfer cask, which are critical issues for IVT system, are under preparation of the demonstration tests to finalize the design of the IVT system. Connection of the rail joint and cable handling test facilities are planned and under fabrication now. These test facility will be installed by the end of March 2008, and the performance tests will be carried out from April 2008

  15. Erosion of wind turbine blade coatings - Design and analysis of jet-based laboratory equipment for performance evaluation

    DEFF Research Database (Denmark)

    Zhang, Shizhong; Dam-Johansen, Kim; Nørkjær, Sten;

    2015-01-01

    blades in such equipment. To reduce expensive blade maintenance repairs and to avoid out-of-service periods, energy-absorbing blade coatings are required to protect rotor blades from rain erosion. In this work we describe the design, construction and evaluation of a laboratory setup for fast screening of...... potential significance of the presence of a thin water film on the coated surfaces. Our results endorse the complex nature of the rain erosion phenomenon, which is the result of the simultaneous combination of complex mechanisms and as such, it is difficult to reproduce at the laboratory scale....

  16. Design of equipment for microwave sterilization of food particulates. Memorandum report

    Energy Technology Data Exchange (ETDEWEB)

    Metaxas, A.C.

    1976-07-01

    The memorandum considers the design of a resonant microwave cavity, operating in the TMsub11(10) mode, for sterilization of liquid foodstuffs or particulates in gravy. The overall design and matching is considered in detail. Preliminary tests have been performed to study the uniformity of heating and optimization of the cavity design. Temperature differences within the cavity of up to 7% of the mean increment were found which may be high for some applications. The cavity utilization efficiency was of the order of 90% and very insensitive to changes in process parameters.

  17. Reaction between protein radicals and other biomolecules

    DEFF Research Database (Denmark)

    Østdal, Henrik; Davies, Michael Jonathan; Andersen, Henrik J

    2002-01-01

    The present study investigates the reactivity of bovine serum albumin (BSA) radicals towards different biomolecules (urate, linoleic acid, and a polypeptide, poly(Glu-Ala-Tyr)). The BSA radical was formed at room temperature through a direct protein-to-protein radical transfer from H(2)O(2....... Subsequent analysis showed a decrease in the concentration of urate upon reaction with the BSA radical, while the BSA radical in the presence of poly(Glu-Ala-Tyr) resulted in increased formation of the characteristic protein oxidation product, dityrosine. Reaction between the BSA radical and a linoleic acid...

  18. Design of electronic measurement and quench detection equipment for the Current Lead Test facility Karlsruhe (CuLTKa)

    International Nuclear Information System (INIS)

    The Current Lead Test facility Karlsruhe (CuLTKa) is under construction at the Karlsruhe Institute of Technology (KIT) to perform acceptance tests of high temperature superconductor (HTS) current leads (CL). CuLTKa is in progress and present planning expects the completion in 2013. The data acquisition system is based on a modular design with electronic measurement and monitoring equipment covering a test voltage of 50 kV DC against ground. It provides plug-in units which enable temperature and voltage measurement at high voltage potential and in addition quench detection units which detect a loss of superconductivity reliably and quickly to avoid damage of the superconducting device under test. Prototype units for quench detection, temperature and voltage measurement have been successfully tested. Six temperature measurement units are already in use in the KIT test facility TOSKA and operated reliably during the acceptance tests of the HTS current leads for Wendelstein 7-X (W7-X) in 2011/2012. CuLTKa will be used first for 26 current leads which will be built in KIT for the fusion experiment JT-60SA. The present paper gives an overview of the design of the electronic measurement and quench detection equipment

  19. Probabilistic risk assessment techniques help in identifying optimal equipment design for in-situ vitrification

    International Nuclear Information System (INIS)

    The analysis discussed in this paper was performed as part of the buried waste remediation efforts at the Idaho National Engineering Laboratory (INEL). The specific type of remediation discussed herein involves a thermal treatment process for converting contaminated soil and waste into a stable, chemically-inert form. Models of the proposed process were developed using probabilistic risk assessment (PRA) fault tree and event tree modeling techniques. The models were used to determine the appropriateness of the conceptual design by identifying potential hazards of system operations. Additional models were developed to represent the reliability aspects of the system components. By performing various sensitivities with the models, optimal design modifications are being identified to substantiate an integrated, cost-effective design representing minimal risk to the environment and/or public with maximum component reliability. 4 figs

  20. Design and initial application of the extended aircraft interrogation and display system: Multiprocessing ground support equipment for digital flight systems

    Science.gov (United States)

    Glover, Richard D.

    1987-01-01

    A pipelined, multiprocessor, general-purpose ground support equipment for digital flight systems has been developed and placed in service at the NASA Ames Research Center's Dryden Flight Research Facility. The design is an outgrowth of the earlier aircraft interrogation and display system (AIDS) used in support of several research projects to provide engineering-units display of internal control system parameters during development and qualification testing activities. The new system, incorporating multiple 16-bit processors, is called extended AIDS (XAIDS) and is now supporting the X-29A forward-swept-wing aircraft project. This report describes the design and mechanization of XAIDS and shows the steps whereby a typical user may take advantage of its high throughput and flexible features.

  1. Thermal design of a fully equipped solar-powered desert home

    KAUST Repository

    Serag-Eldin, M.A.

    2010-03-01

    The paper presents a conceptual design and thermodynamic analysis of a solar-powered desert home. The home is airconditioned and provides all modern comforts and facilities. Electrical power, which drives the entire energy system, is generated by roof mounted photovoltaic modules. A detailed dynamic heat transfer analysis is conducted for the building envelope, coupled with a solar radiation model. A dynamic heat balance for a typical Middle-Eastern desert site, reveals that indeed such a design is feasible with present day technology; and should be even more attractive with future advances in technology.

  2. Porous solid ion exchange wafer for immobilizing biomolecules

    Science.gov (United States)

    Arora, Michelle B.; Hestekin, Jamie A.; Lin, YuPo J.; St. Martin, Edward J.; Snyder, Seth W.

    2007-12-11

    A porous solid ion exchange wafer having a combination of a biomolecule capture-resin and an ion-exchange resin forming a charged capture resin within said wafer. Also disclosed is a porous solid ion exchange wafer having a combination of a biomolecule capture-resin and an ion-exchange resin forming a charged capture resin within said wafer containing a biomolecule with a tag. A separate bioreactor is also disclosed incorporating the wafer described above.

  3. Teaching Computer-Aided Design of Fluid Flow and Heat Transfer Engineering Equipment.

    Science.gov (United States)

    Gosman, A. D.; And Others

    1979-01-01

    Describes a teaching program for fluid mechanics and heat transfer which contains both computer aided learning (CAL) and computer aided design (CAD) components and argues that the understanding of the physical and numerical modeling taught in the CAL course is essential to the proper implementation of CAD. (Author/CMV)

  4. Application of mapping crossover genetic algorithm in nuclear power equipment optimization design

    International Nuclear Information System (INIS)

    Genetic algorithm (GA) has been widely applied in nuclear engineering. An improved method, named the mapping crossover genetic algorithm (MCGA), was developed aiming at improving the shortcomings of traditional genetic algorithm (TGA). The optimal results of benchmark problems show that MCGA has better optimizing performance than TGA. MCGA was applied to the reactor coolant pump optimization design. (authors)

  5. Probabilistic assessment of lightning striking the equipment at the Hanford Site 241-SY tank farm relative to two different designs of lightning protection

    International Nuclear Information System (INIS)

    The one-million-gallon waste-storage tank 241-SY-101 in the Hanford Site 241-SY Tank Farm has been under intense scrutiny because of the production and venting of hydrogen and nitrous oxide gases. This potentially reactive mixture of gases could be ignited by an ignition was a direct lightning strike on equipment in the 241-SY Tank Farm. A probabilistic assessment of two designs of lightning protection was performed to evaluate probabilities of lightning strikes on equipment and the estimated costs of the two lightning protection designs. The two lightning protection designs were (1) a open-quotes lightning rodclose quotes design with two telephone poles and some cable serving as the lightning rods and (2) the same system as described in (1) but with metal enclosures around each piece of equipment of concern. The assessment used information presented in IEEE-142, IEEE Recommended Practice for Grounding of Industrial and Commercial Power Systems (Institute of Electrical and Electronics Engineers, Inc., New York City, New York), plus Hanford Site-specific weather data. The results of the assessment indicated that the addition of metal enclosures around each piece of equipment reduced the probability of a direct lightning strike on the equipment from 4 E-06 to 8 E-08 during a 27-day period of concern. The conclusion of the assessment was that the cost of constructing metal enclosures around each piece of equipment was greater than the benefit from reducing the probability of a direct lightning strike on the equipment

  6. Shock Syntheses of Novel Nitrides and Biomolecules

    Science.gov (United States)

    Sekine, Toshimori

    2013-06-01

    High-pressure spinel nitride of Si3N4 was discovered more than 10 years ago. Since then there have been many studies on the spinel nitrides and related materials including oxynitrides. We have developed shock synthesis method to investigate their structural, mechanical, chemical, physical, and optical properties. At the same time we tried to synthesize carbon nitrides from the organic substances. And later we extended to shock synthesis of ammonia through the Haber-Bosch reaction under shock in order to apply geochemical subjects related to the origin of life. The simplest amino acid of glycine, as well as animes (up to propylamine) and carboxylic acids (up to pentanoic acid), has been synthesized successfully in aqueous solutions through meteoritic impact reactions. Recently we are trying to make more complex biomolecules for implications of biomolecule formation for the origin of life through meteorite impacts on early Earth's ocean. These results of shock syntheses may imply significant contributions to materials science and Earth and planetary sciences. This research is collaborated with National Institute for Materials Science and Tohoku University.

  7. Design and development of electric vehicle charging station equipped with RFID

    Science.gov (United States)

    Panatarani, C.; Murtaddo, D.; Maulana, D. W.; Irawan, S.; Joni, I. M.

    2016-02-01

    This paper reports the development of electric charging station from distributed renewable for electric vehicle (EV). This designed refer to the input voltage standard of IEC 61851, plugs features of IEC 62196 and standard communication of ISO 15118. The developed electric charging station used microcontroller ATMEGA8535 and RFID as controller and identifier of the EV users, respectively. The charging station successfully developed as desired features for electric vehicle from renewable energy resources grid with solar panel, wind power and batteries storage.

  8. Design of experiments and equipment to test the ballooning characteristics of CANDU pressure tubes

    International Nuclear Information System (INIS)

    Experiments have been planned and an apparatus has been designed to enable creep testing of end-of-life pressure tube specimens in a LOCA environment. Effects that could be studied include: annealing of irradiation damage during transient heating; effects of hydride blisters on pressure tube ballooning strains; and, effects of uniformly-distributed hydrogen content on pressure tube ballooning strains. The proposed experimental program will consist of separate effects creep tests on pressure tube sections under transient heating conditions

  9. A VLSI design for universal noiseless coding. [for spacecraft imaging equipment

    Science.gov (United States)

    Lee, Jun-Ji; Fang, Wai-Chi; Rice, Robert F.

    1988-01-01

    The practical, noiseless and efficient data-compression technique presented involves a conceptual VLSI design which is capable of meeting real-time processing rates and meets low-power, low-weight, and small-volume requirements. This form of data compression is applicable to image data compression aboard future low-budget spaceflight missions, for such instruments as visual-IR mapping spectrometers and high-resolution imaging spectrometers.

  10. Rationalization design on large equipment dismantling facility. The cell fire-extinguishing examination. 1. Technical report

    International Nuclear Information System (INIS)

    In order to rationalize for Large Equipment Dismantling Facility (LEDF), the plan of removing vaporizer belong to Cell-fire-extinguishing-system was investigated. In this test, in order to study the behavior of pressure in cell, when the liquefaction carbon dioxide (liq-CO2) is emitted, and the performance of extinguishing fires, the test of behavior. of pressure and the extinguishing fires take effect. Also the extinguishing fires test used water-mist take effect for complement liq-CO2. The results as follows; (1) In the test of behavior of pressure, Liq-CO2 was emitted test room under -40 mmAq negative pressure. Room pressure was increase about 0.8 mmAq/sec at first. After 20 sec, the pressure was increase slowly about 0.1 mmAq/sec. After 120 sec,the increase was drastic about 1.5 mmAq/s. (2) In the test of extinguishing fires by liq-CO2, under -40 mmAq, Polyethylene and wooden chips + cotton (crib) was burn. Polyethylene was extinguished perfectly, but the embers remained in cribs. While the room pressure was increase about 1.3 mmAq/sec for 10 sec at first. After 30 sec, the pressure was increase about 1 mmAq/sec. On the other hand, the drastic increase of pressure disappeared between 100 sec to 120 sec by change the nozzle size from 14 mm2 to 10 mm2. (3) In the test of extinguishing fires by water-mist, Cribs was extinguished perfectly, but Polyethylene was extinguished difficulty under the same condition of liq-CO2 test. (4) Therefore the results, It's coped with the fire extinguishing and the keeping negative 2 pressure for LEDF cells. Therefore nozzle size is fitted cell volume as changing 14 mm2 to 10 mm2 (5) As the performance of extinguishing fires by liq-CO2, It is necessity the concentration of above 50% CO2 for combustibles as cribs, remaining the embers. (6) On the other hand, It is necessity most study for the adoption of water-mist. Therefore water-mist was not effective for polyethylene, and it needed water for fire in great volume. (author)

  11. Interfacial water thickness at inorganic nanoconstructs and biomolecules: Size matters

    Science.gov (United States)

    Cardellini, Annalisa; Fasano, Matteo; Chiavazzo, Eliodoro; Asinari, Pietro

    2016-04-01

    Water molecules in the proximity of solid nanostructures influence both the overall properties of liquid and the structure and functionality of solid particles. The study of water dynamics at solid-liquid interfaces has strong implications in energy, environmental and biomedical fields. This article focuses on the hydration layer properties in the proximity of Carbon Nanotubes (CNTs) and biomolecules (proteins, polypeptides and amino acids). Here we show a quantitative relation between the solid surface extension and the characteristic length of water nanolayer (δ), which is confined at solid-liquid interfaces. Specifically, the size dependence is attributed to the limited superposition of nonbonded interactions in case of small molecules. These results may facilitate the design of novel energy or biomedical colloidal nanosuspensions, and a more fundamental understanding of biomolecular processes influenced by nanoscale water dynamics.

  12. a New Design for Diamond Window Equipped Paris-Edinburgh — First Tests and Results

    Science.gov (United States)

    Burchard, M.; Glasmacher, U. A.; Dedera, S.; Trautmann, C.

    2012-12-01

    High pressure cells of the Paris-Edinburgh type are important tools for experimental high pressure studies in material science. Although these cells were originally developed for use in neutron diffraction, today they are also applied in alternative experimental high pressure fields. Their main advantages are their small construction size, limited weight and the relative high reachable pressures with a maximized sample volume. The small construction size also results in very good cost efficiency. The major drawback of these cells is that due to their simple squeezer geometry pressure extrapolations are nearly impossible and, hence, the use of internal standard is mandatory. Consequently, the normal use of Paris-Edinburgh cells is mostly limited to experiments with neutron or synchrotron radiation, during which pressure and temperature are determined by using an internal diffraction standard. To overcome this problem, tone may combine the advantages of diamond anvil cells with those of Paris-Edinburgh-cells by integrating diamond windows into the upper and / or the lower anvil. With such a cell it is possible to retrieve pressure and / or temperature data by measuring the shift of Raman bands or fluorescence lines by spectroscopic methods. Several attempts have been made to build such a cell ([1] and Klotz pers. communication) using different window materials. Until now no final setup has been published. We present a new Paris-Edinburgh cell design especially constructed for use within high energy relativistic heavy ion radiation experiments. This design uses conventional diamond anvils as spectroscopic windows in conjunction with specially designed hardened steel anvils. We have performed first feasibility studies up to 2.5 GPa with a standard Raman spectrometer using a special adapted Raman glass fiber probe. We present results of several mechanical test runs and one experiment with relativistic heavy ion radiation at the GSI Helmholtzzentrum f

  13. Climate design of vegetable oil fuels for agricultural equipment; Klimadesign von Pflanzenoelkraftstoffen fuer landwirtschaftliche Maschinen

    Energy Technology Data Exchange (ETDEWEB)

    Stoehr, Michael [B.A.U.M. Consult GmbH, Muenchen (Germany). International and Energy Projects; Pickel, Peter [John Deere European Technology Innovation Center, Kaiserslautern (Germany)

    2012-07-01

    The use of biofuels in agricultural machinery is an option for complying with climate protection requirements that are presently discussed to be placed on manufacturers of mobile off-road machinery by the European Commission. A mathematical model has been developed that allows calculating greenhouse gas emissions (GHGE) of biofuels for complex production paths in a straightforward, transparent manner and in pattern with the EU's Fuel Quality Directive (FQD). Therewith it has been shown that both rape seed and camelina sativa oil fuels can save more than 60 % GHGE. Key parameters have been identified and rules for a climate design of vegetable oil fuels have been formulated. (orig.)

  14. Design of data acquisition system and algorithm research for omnidirectional gamma-ray positioning equipment

    International Nuclear Information System (INIS)

    This article introduces the design and performance of the data acquisition system used in an omnidirectional gamma-ray positioning system, along with a new method used in this system to obtain the position of radiation sources in a large field. This data acquisition system has various built-in interfaces collecting, in real time, information from the radiation detector, the video camera and the GPS positioning module. Experiments show that the data acquisition system is capable of carrying out the proposed quantitative analysis to derive the position of radioactive sources, which also satisfies the requirements of high stability and reliability. (authors)

  15. Permanent group of experts for nuclear pressure equipment (GPESPN) - Session of the 14 September 2011: Examination of design options for nuclear pressure equipment of the primary circuit and main secondary circuits of the ATMEA 1 reactor project

    International Nuclear Information System (INIS)

    This report discusses the elements stated by ATMEA regarding the design options of nuclear pressure equipment of the primary and secondary circuits of the ATMEA 1 reactor project. Several design aspects are addressed: the steam generator, the vessel and its inner parts, the cluster control mechanisms, the primary motor-pump groups, the primary and main secondary pipes, the pressurizer, the protection of the primary and main secondary circuits against overpressures. Related ASN documents are provided

  16. Design of an equipment for the testing of target dedicated to the production of radioactive ions through the ISOL method

    International Nuclear Information System (INIS)

    In the ISOL (isotope separation on line) technique, a primary ion beam impinges on a thick target, the incident ions are stopped through fragmentation reactions that generate radioactive nuclei. As soon as they have collected enough electrons, the radioactive nuclei begin diffusing outside the target as radioactive atoms. In order to improve this diffusion the target is strongly heated. The radioactive atoms diffuse till a ion source that ionize them, they are then accelerated to form a secondary beam that is delivered to the experimental area. This work deals with the design of an equipment able to measure the diffusion capacities of various targets, it is made up of -) a high temperature (> 2300 K) oven that will contain the target, -) a ionization source for ionizing radioactive atoms and -) a target dispatcher able to introduce in the oven or remove from the oven any target of a set of 12 targets. This equipment has proved to be able to test during a single experiment several primary beams and target materials. Measurements will be performed in a sequential way for the different projectile-target couples which will assure very closed experimental conditions for each measuring campaign. (A.C.)

  17. Design of lubricating equipment of stud hole's threads of reactor pressure vessel

    International Nuclear Information System (INIS)

    It is determined that lubrication method of reactor pressure vessel (RPV) stud hole's thread is brushing lubrication by flow test of N5000 grease. The basic requirements of RPV stud hole's thread lubrication are all-surface and uniformity of greasing. The RPV stud hole lubricating machine is mainly composed of control panel, cable hanging device, automatic trolley and lubricating device. The lubricating device is the key part of RPV stud hole lubricating machine, therefore, the structure and principle of lubricating device are described. Besides, its operating principle, technical characteristics and design features are briefly described. During refuelling and repairing of No.1 unit of Daya Bay Nuclear Power Plant RPV, stud hole's lubricating machine are practically used. The practical using of RPV stud hole's lubricating machine proved that its all technical characteristics and functions have already met requirements of technical specification of the proprietor

  18. Conceptual design studies of in-vessel viewing equipment for ITER

    International Nuclear Information System (INIS)

    In-vessel viewing systems are essential to inspect all surface of in-vessel components so as to detect and locate damages, and to assist in-vessel maintenance operations. The in-vessel viewing operations are categorized into the three cases, which are 1) rapid inspection just after off-normal events such as disruption, 2) scheduled inspection, and 3) supplementary inspection during maintenance operations. In case of the rapid inspection, the viewing systems have to be operated in vacuum (ca. 10-5Pa) and high temperature (ca. 300degC) under a gamma ray dose rate of 107 R/h. On the other hand, the latter two cases are anticipated to be under atmospheric inert gas, 150degC and 3x106 R/h. Accordingly, the in-vessel viewing systems are required to have sufficient durability under those conditions of all cases as well as precision of the vision to all of in-vessel surface. Based on those requirements, scoping studies on various viewing concepts have been performed and the applicability to the ITER conditions have been assessed. As a result, two types of viewing systems have been chosen, which are a periscope type viewing system and a image fiber type viewing system with a multi-joint manipulator. Both systems are based on radiation hard optical elements which are being developed. In this report, the design features of both viewing systems are described, including technical issues for ITER application. Finally, a periscope type viewing system is recommended as a primary system and the following specifications/conditions are proposed for the further engineering design. (1) Unified type periscope with a movable mirror at the tip (2) Integrated lighting device into the periscope (3) Accessed from top vertical ports located at 7.3m from the machine center (4) Proposed configuration with a total length of around 27m and a diameter of 200mm. (author)

  19. Electrical insulation design and evaluation of 60 kV prototype condenser cone bushing for the superconducting equipment

    International Nuclear Information System (INIS)

    Highlights: •The optimum design of condenser cone cryogenic bushing was investigated. •Multi-layer aluminum foils in the bushing insulation body was designed and analyzed. •The optimum electric field distribution was selected by simulation. •The 60 kV FRP condenser cone cryogenic bushing was fabricated and tested. •BIL test corresponding to IEC 60137 was successfully performed for the bushing. -- Abstract: A cryogenic bushing is an essential component to be developed for commercial applications of high voltage (HV) superconducting devices. Due to the steep temperature gradient of the ambient of cryogenic bushing, general gas bushing adopting SF6 gas as an insulating media could not be directly used due to the freezing of SF6 gas. Therefore, condenser type bushing with special material considering cryogenic environment would be better choice for superconducting equipment. Considering these circumstance, we focused on the design of condenser bushing made of fiber reinforced plastic (FRP). In case of the design of the condenser bushing, it is very important to reduce the electric field intensification on the mounted flange part of the cryostat, which is the most vulnerable part of bushings. In this paper, design factors of cryogenic bushing were analyzed, and finally 60 kV condenser bushing was fabricated and tested. In order to achieve optimal electric field configuration, the configuration of condenser cone was determined using 2D electric field simulation results. Based on the experimental and the analytical works, 60 kV FRP condenser bushing was fabricated. Finally, the fabricated condenser bushing has been tested by applying lightning impulse and AC overvoltage test. From the test results, it was possible to get satisfactory results which confirm the design of cryogenic bushing in cryogenic environment

  20. The influence of deposition parameters and gaseous detonation equipment design on the coating formation

    International Nuclear Information System (INIS)

    The paper devoted to the problems of development of the problem-oriented dialogue program complex for direct computational experiment in the chain detonation gun -gas-powder feeding-high-temperature high-velocity jet- coating. The formation of structure and properties of coatings are determining by large quantity of factors. At the first approaching the conditions of coatings formation are determined by shape, sizes, velocity and temperature of particles, their texture and aggregative state, spatio-temporal distribution of powder particles into impulse heterogeneous jet, microrelief, texture and temperature gradient of substrate surface layer, rate of fire, etc. More detailed consideration is demanding taking into account a number of other factors as used gas mixture, spatio- temporal characteristics of fresh charge into barrel, kinematics of spraying process, design philosophy of sprayed component, main material, etc. However, the starting point in this complicated process of coating obtaining is the formation of start elements of coating in the form of individual particles sprayed onto substrate. The systems of mathematical models and information interchange in the time of optimization of engineering procedures of detonation spraying of coatings are examined. The base of an expert system to assist detonation spray coating process is a dialogue modeling complex. It represent a stationary developed complex of methodical, algorithmic, software and information environment, which assure the essential promotion of effectiveness of development work, investigations and training. (author)

  1. Regulatory Guide 1.122: Development of floor design response spectra for seismic design of floor-supported equipment or components

    International Nuclear Information System (INIS)

    ''Reactor Site Criteria,'' requires, in part, that safety-related structures, systems, and components remain functional in the event of a Safe Shutdown Earthquake (SSE). It specifies the use of a suitable dynamic analysis as one method of ensuring that the structures, systems, and components can withstand the seismic loads. Similarly, paragraph (a)(2) of Section VI of the same appendix requires, in part, that the structures, systems, and components necessary for continued operation without undue risk to the health and safety of the public remain functional in the event of an Operating Basis Earthquake (OBE). Again, the use of suitable dynamic analysis is specified as one method of ensuring that the structures, systems, and components can withstand the seismic loads. This guide describes methods acceptable to the NRC staff for developing two horizontal and one vertical floor design response spectra at various floors or other equipment-support locations of interest from the time-history motions resulting from the dynamic analysis of the supporting structure. These floor design response spectra are needed for the dynamic analysis of the systems or equipment supported at various locations of the supporting structure

  2. The performance of a prototype device designed to evaluate general quality parameters of X-ray equipment

    Science.gov (United States)

    Murata, C. H.; Fernandes, D. C.; Lavínia, N. C.; Caldas, L. V. E.; Pires, S. R.; Medeiros, R. B.

    2014-02-01

    The performance of radiological equipment can be assessed using non-invasive methods and portable instruments that can analyze an X-ray beam with just one exposure. These instruments use either an ionization chamber or a state solid detector (SSD) to evaluate X-ray beam parameters. In Brazil, no such instruments are currently being manufactured; consequently, these instruments come at a higher cost to users due to importation taxes. Additionally, quality control tests are time consuming and impose a high workload on the X-ray tubes when evaluating their performance parameters. The assessment of some parameters, such as the half-value layer (HVL), requires several exposures; however, this can be reduced by using a SSD that requires only a single exposure. One such SSD uses photodiodes designed for high X-ray sensitivity without the use of scintillation crystals. This sensitivity allows one electron-hole pair to be created per 3.63 eV of incident energy, resulting in extremely high and stable quantum efficiencies. These silicon photodiodes operate by absorbing photons and generating a flow of current that is proportional to the incident power. The aim of this study was to show the response of the solid sensor PIN RD100A detector in a multifunctional X-ray analysis system that is designed to evaluate the average peak voltage (kVp), exposure time, and HVL of radiological equipment. For this purpose, a prototype board that uses four SSDs was developed to measure kVp, exposure time, and HVL using a single exposure. The reproducibility and accuracy of the results were compared to that of different X-ray beam analysis instruments. The kVp reproducibility and accuracy results were 2% and 3%, respectively; the exposure time reproducibility and accuracy results were 2% and 1%, respectively; and the HVL accuracy was ±2%. The prototype's methodology was able to calculate these parameters with appropriate reproducibility and accuracy. Therefore, the prototype can be considered

  3. Design and Analysis of a Spurious Switching Suppression Technique Equipped Low Power Multiplier with Hybrid Encoding Scheme

    Directory of Open Access Journals (Sweden)

    M.Madheswaran

    2009-12-01

    Full Text Available Multiplication is an arithmetic operation that is mostly used in Digital Signal Processing (DSP and communication applications. Efficient implementation of the multipliers is required in many applications. The design and analysis of Spurious Switching Suppression Technique (SSST equipped low power multiplier with hybrid encoding is presented in this paper. The proposed encoding technique reduces the number of switching activity and dynamic power consumption by analyzing the bit patterns in the input data. In this proposed encoding scheme, the operation is executed depends upon the number of 1’s and its position in the multiplier data. The architecture of the proposed multiplier is designed using a low power full adder which consumes less power than the other adder architectures. The switching activity of the proposed multiplier has been reduced by 86% and 46% compared with conventional and Booth multiplier respectively. It is observed from the device level simulation using TANNER 12.6 EDA that the power consumption of the proposed multiplier has been reduced by 87% and 26% compared with conventional and Booth multiplier. Keywords-component; Low power VLSI Design, Booth Multiplier, Hybrid encoding.

  4. Poster — Thur Eve — 56: Design of Quality Assurance Methodology for VMAT system on Agility System equipped with CVDR

    Energy Technology Data Exchange (ETDEWEB)

    Thind, K; Tolakanahalli, R [Walker Family Cancer Center, Hamilton Health Science, Hamilton, ON (Canada)

    2014-08-15

    The aim of this study was to analyze the feasibility of designing comprehensive QA plans using iComCAT for Elekta machines equipped with Agility multileaf collimator and continuously variable dose rate. Test plans with varying MLC speed, gantry speed, and dose rate were created and delivered in a controlled manner. A strip test was designed with three 1 cm MLC positions and delivered using dynamic, StepNShoot and VMAT techniques. Plans were also designed to test error in MLC position with various gantry speeds and various MLC speeds. The delivery fluence was captured using the electronic portal-imaging device. Gantry speed was found to be within tolerance as per the Canadian standards. MLC positioning errors at higher MLC speed with gravity effects does add more than 2 mm discrepancy. More tests need to be performed to evaluate MLC performance using independent measurement systems. The treatment planning system with end-to-end testing necessary for commissioning was also investigated and found to have >95% passing rates within 3%/3mm gamma criteria. Future studies involve performing off-axis gantry starshot pattern and repeating the tests on three matched Elekta linear accelerators.

  5. Poster — Thur Eve — 56: Design of Quality Assurance Methodology for VMAT system on Agility System equipped with CVDR

    International Nuclear Information System (INIS)

    The aim of this study was to analyze the feasibility of designing comprehensive QA plans using iComCAT for Elekta machines equipped with Agility multileaf collimator and continuously variable dose rate. Test plans with varying MLC speed, gantry speed, and dose rate were created and delivered in a controlled manner. A strip test was designed with three 1 cm MLC positions and delivered using dynamic, StepNShoot and VMAT techniques. Plans were also designed to test error in MLC position with various gantry speeds and various MLC speeds. The delivery fluence was captured using the electronic portal-imaging device. Gantry speed was found to be within tolerance as per the Canadian standards. MLC positioning errors at higher MLC speed with gravity effects does add more than 2 mm discrepancy. More tests need to be performed to evaluate MLC performance using independent measurement systems. The treatment planning system with end-to-end testing necessary for commissioning was also investigated and found to have >95% passing rates within 3%/3mm gamma criteria. Future studies involve performing off-axis gantry starshot pattern and repeating the tests on three matched Elekta linear accelerators

  6. Bioconjugation and stabilisation of biomolecules in biosensors.

    Science.gov (United States)

    Liébana, Susana; Drago, Guido A

    2016-06-30

    Suitable bioconjugation strategies and stabilisation of biomolecules on electrodes is essential for the development of novel and commercially viable biosensors. In the present review, the functional groups that comprise the selectable targets for practical bioconjugation methods are discussed. We focus on describing the most common immobilisation techniques used in biosensor construction, which are classified into irreversible and reversible methods. Concerning the stability of proteins, the two main types of stability may be defined as (i) storage or shelf stability, and (ii) operational stability. Both types of stability are explained, as well as the introduction of an electrophoretic technique for predicting protein-polymer interactions. In addition, solution and dry stabilisation as well as stabilisation using the covalent immobilisation of proteins are discussed including possible factors that influence stability. Finally, the integration of nanomaterials, such as magnetic particles, with protein immobilisation is discussed in relation to protein stability studies. PMID:27365036

  7. 'Smartening' anticancer therapeutic nanosystems using biomolecules.

    Science.gov (United States)

    Núñez-Lozano, Rebeca; Cano, Manuel; Pimentel, Belén; de la Cueva-Méndez, Guillermo

    2015-12-01

    To be effective, anticancer agents must induce cell killing in a selective manner, something that is proving difficult to achieve. Drug delivery systems could help to solve problems associated with the lack of selectivity of classical chemotherapeutic agents. However, to realize this, such systems must overcome multiple physiological barriers. For instance, they must evade surveillance by the immune system, attach selectively to target cells, and gain access to their interior. Furthermore, there they must escape endosomal entrapment, and release their cargoes in a controlled manner, without affecting their functionality. Here we review recent efforts aiming at using biomolecules to confer these abilities to bare nanoparticles, to transform them into smart anticancer therapeutic nanosystems. PMID:26277646

  8. A quasi-static continuum model describing interactions between plasmons and non-absorbing biomolecules

    Science.gov (United States)

    Salary, Mohammad Mahdi; Mosallaei, Hossein

    2015-06-01

    Interactions between the plasmons of noble metal nanoparticles and non-absorbing biomolecules forms the basis of the plasmonic sensors, which have received much attention. Studying these interactions can help to exploit the full potentials of plasmonic sensors in quantification and analysis of biomolecules. Here, a quasi-static continuum model is adopted for this purpose. We present a boundary-element method for computing the optical response of plasmonic particles to the molecular binding events by solving the Poisson equation. The model represents biomolecules with their molecular surfaces, thus accurately accounting for the influence of exact binding conformations as well as structural differences between different proteins on the response of plasmonic nanoparticles. The linear systems arising in the method are solved iteratively with Krylov generalized minimum residual algorithm, and the acceleration is achieved by applying precorrected-Fast Fourier Transformation technique. We apply the developed method to investigate interactions of biotinylated gold nanoparticles (nanosphere and nanorod) with four different types of biotin-binding proteins. The interactions are studied at both ensemble and single-molecule level. Computational results demonstrate the ability of presented model for analyzing realistic nanoparticle-biomolecule configurations. The method can provide comprehensive study for wide variety of applications, including protein structures, monitoring structural and conformational transitions, and quantification of protein concentrations. In addition, it is suitable for design and optimization of the nano-plasmonic sensors.

  9. Assembly and actuation of nanomaterials using active biomolecules.

    Energy Technology Data Exchange (ETDEWEB)

    Spoerke, Erik David; Thayer, Gayle Echo; de Boer, Maarten Pieter; Bunker, Bruce Conrad; Liu, Jun; Corwin, Alex David; Gaudioso, Jennifer Marie; Sasaki, Darryl Yoshio; Boal, Andrew Kiskadden; Bachand, George David; Trent, Amanda M.; Bachand, Marlene; Rivera, Susan B.; Koch, Steven John

    2005-11-01

    The formation and functions of living materials and organisms are fundamentally different from those of synthetic materials and devices. Synthetic materials tend to have static structures, and are not capable of adapting to the functional needs of changing environments. In contrast, living systems utilize energy to create, heal, reconfigure, and dismantle materials in a dynamic, non-equilibrium fashion. The overall goal of the project was to organize and reconfigure functional assemblies of nanoparticles using strategies that mimic those found in living systems. Active assembly of nanostructures was studied using active biomolecules to drive the organization and assembly of nanocomposite materials. In this system, kinesin motor proteins and microtubules were used to direct the transport and interactions of nanoparticles at synthetic interfaces. In addition, the kinesin/microtubule transport system was used to actively assemble nanocomposite materials capable of storing significant elastic energy. Novel biophysical measurement tools were also developed for measuring the collective force generated by kinesin motor proteins, which will provide insight on the mechanical constraints of active assembly processes. Responsive reconfiguration of nanostructures was studied in terms of using active biomolecules to mediate the optical properties of quantum dot (QD) arrays through modulation of inter-particle spacing and associated energy transfer interaction. Design rules for kinesin-based transport of a wide range of nanoscale cargo (e.g., nanocrystal quantum dots, micron-sized polymer spheres) were developed. Three-dimensional microtubule organizing centers were assembled in which the polar orientation of the microtubules was controlled by a multi-staged assembly process. Overall, a number of enabling technologies were developed over the course of this project, and will drive the exploitation of energy-driven processes to regulate the assembly, disassembly, and dynamic

  10. Equipment concept design and development plans for microgravity science and applications research on space station: Combustion tunnel, laser diagnostic system, advanced modular furnace, integrated electronics laboratory

    Science.gov (United States)

    Uhran, M. L.; Youngblood, W. W.; Georgekutty, T.; Fiske, M. R.; Wear, W. O.

    1986-01-01

    Taking advantage of the microgravity environment of space NASA has initiated the preliminary design of a permanently manned space station that will support technological advances in process science and stimulate the development of new and improved materials having applications across the commercial spectrum. Previous studies have been performed to define from the researcher's perspective, the requirements for laboratory equipment to accommodate microgravity experiments on the space station. Functional requirements for the identified experimental apparatus and support equipment were determined. From these hardware requirements, several items were selected for concept designs and subsequent formulation of development plans. This report documents the concept designs and development plans for two items of experiment apparatus - the Combustion Tunnel and the Advanced Modular Furnace, and two items of support equipment the Laser Diagnostic System and the Integrated Electronics Laboratory. For each concept design, key technology developments were identified that are required to enable or enhance the development of the respective hardware.

  11. Preliminary Equipment List

    International Nuclear Information System (INIS)

    The methodology for assigning equipment identifiers and component identifiers for the MGR Site Recommendation or License Application is presented below. Engineering Computer Support (ECS) assigns all equipment and component identifiers and is responsible for entering equipment identifiers into the Plant Design System (PDS) Master Equipment List. A sample report from the PDS Master Equipment List is attached. The attached report is representative of the information that will be provided by the PDS system. Since the equipment list presented is only preliminary, actual equipment numbers are not assigned. It contains information required to maintain control of the equipment and components for MGR important to safety systems. Definitions for the fields that currently exist on the PDS Master Equipment List are given

  12. The design of in-cell equipment for nuclear fuel reprocessing plant with special reference to the decanners for Pond 5, Sellafield

    International Nuclear Information System (INIS)

    The in-cave equipment has to meet many demanding criteria, which require not only sound and creative design thinking, but a range of design management techniques to ensure the success of the plant. This paper discusses these in some detail in relation to the decanners for Pond 5. (author)

  13. Preparation of supramolecular hydrogel-enzyme hybrids exhibiting biomolecule-responsive gel degradation.

    Science.gov (United States)

    Shigemitsu, Hajime; Fujisaku, Takahiro; Onogi, Shoji; Yoshii, Tatsuyuki; Ikeda, Masato; Hamachi, Itaru

    2016-09-01

    Hydrogelators are small, self-assembling molecules that form supramolecular nanofiber networks that exhibit unique dynamic properties. Development of supramolecular hydrogels that degrade in response to various biomolecules could potentially be used for applications in areas such as drug delivery and diagnostics. Here we provide a synthetic procedure for preparing redox-responsive supramolecular hydrogelators that are used to create hydrogels that degrade in response to oxidizing or reducing conditions. The synthesis takes ∼2-4 d, and it can potentially be carried out in parallel to prepare multiple hydrogelator candidates. This described solid-phase peptide synthesis protocol can be used to produce previously described hydrogelators or to construct a focused molecular library to efficiently discover and optimize new hydrogelators. In addition, we describe the preparation of redox-responsive supramolecular hydrogel-enzyme hybrids that are created by mixing aqueous solutions of hydrogelators and enzymes, which requires 2 h for completion. The resultant supramolecular hydrogel-enzyme hybrids exhibit gel degradation in response to various biomolecules, and can be rationally designed by connecting the chemical reactions of the hydrogelators with enzymatic reactions. Gel degradation in response to biomolecules as triggers occurs within a few hours. We also describe the preparation of hydrogel-enzyme hybrids arrayed on flat glass slides, enabling high-throughput analysis of biomolecules such as glucose, uric acid, lactate and so on by gel degradation, which is detectable by the naked eye. The protocol requires ∼6 h to prepare the hydrogel-enzyme hybrid array and to complete the biomolecule assay. PMID:27560177

  14. Ionic strength independence of charge distributions in solvation of biomolecules.

    Science.gov (United States)

    Virtanen, J J; Sosnick, T R; Freed, K F

    2014-12-14

    Electrostatic forces enormously impact the structure, interactions, and function of biomolecules. We perform all-atom molecular dynamics simulations for 5 proteins and 5 RNAs to determine the dependence on ionic strength of the ion and water charge distributions surrounding the biomolecules, as well as the contributions of ions to the electrostatic free energy of interaction between the biomolecule and the surrounding salt solution (for a total of 40 different biomolecule/solvent combinations). Although water provides the dominant contribution to the charge density distribution and to the electrostatic potential even in 1M NaCl solutions, the contributions of water molecules and of ions to the total electrostatic interaction free energy with the solvated biomolecule are comparable. The electrostatic biomolecule/solvent interaction energies and the total charge distribution exhibit a remarkable insensitivity to salt concentrations over a huge range of salt concentrations (20 mM to 1M NaCl). The electrostatic potentials near the biomolecule's surface obtained from the MD simulations differ markedly, as expected, from the potentials predicted by continuum dielectric models, even though the total electrostatic interaction free energies are within 11% of each other. PMID:25494774

  15. GroPBS: Fast Solver for Implicit Electrostatics of Biomolecules

    Directory of Open Access Journals (Sweden)

    Franziska eBertelshofer

    2015-11-01

    Full Text Available Knowledge about the electrostatic potential on the surface of biomolecules or biomembranes under physiological conditions is an important step in the attempt to characterize the physico-chemical properties of these molecules and in particular also their interactions with each other. Additionally, knowledge about solution electrostatics may guide also the design of molecules with specified properties. However, explicit water models come at a high computational cost, rendering them unsuitable for large design studies or for docking purposes. Implicit models with the water phase treated as a continuum require the numerical solution of the Poisson-Boltzmann Equation (PBE. Here, we present a new flexible program for the numerical solution of the PBE, allowing for different geometries, and the explicit and implicit inclusion of membranes. It involves a discretization of space and the computation of the molecular surface. The PBE is solved using finite differences, the resulting set of equations is solved using a Gauss-Seidel method. It is shown for the example of the sucrose transporter ScrY that the implicit inclusion of a surrounding membrane has a strong effect also on the electrostatics within the pore region and thus need to be carefully considered e.g. in design studies on membrane proteins.

  16. Noncovalent Labeling of Biomolecules with Red and Near- Infrared Dyes

    Directory of Open Access Journals (Sweden)

    Lucjan Strekowski

    2004-02-01

    Full Text Available Biopolymers such as proteins and nucleic acids can be labeled with a fluorescent marker to allow for their detection. Covalent labeling is achieved by the reaction of an appropriately functionalized dye marker with a reactive group on a biomolecule. The recent trend, however, is the use of noncovalent labeling that results from strong hydrophobic and/or ionic interactions between the marker and biomolecule of interest. The main advantage of noncovalent labeling is that it affects the functional activity of the biomolecule to a lesser extent. The applications of luminescent cyanine and squarylium dyes are reviewed.

  17. Experimental Beam Studies of Plasma-generated Species Interaction with Polymeric Materials and Biomolecules

    OpenAIRE

    Chung, Ting-Ying

    2012-01-01

    Low temperature plasma-based processes are used extensively in many modern technologies. It is thus very important to understand plasma and surface interactions in order to improve plasma processes and design of functional materials. Applying a high vacuum beam system, this dissertation studies the fundamental mechanisms of plasma species-induced modification of materials for two critical applications: manufacturing of semiconductor devices and surface deactivation of infectious biomolecules....

  18. Microfluidic Radiometal Labeling Systems for Biomolecules

    Energy Technology Data Exchange (ETDEWEB)

    Reichert, D E; Kenis, P J. A.

    2011-12-29

    In a typical labeling procedure with radiometals, such as Cu-64 and Ga-68; a very large (~ 100-fold) excess of the non-radioactive reactant (precursor) is used to promote rapid and efficient incorporation of the radioisotope into the PET imaging agent. In order to achieve high specific activities, careful control of reaction conditions and extensive chromatographic purifications are required in order to separate the labeled compounds from the cold precursors. Here we propose a microfluidic approach to overcome these problems, and achieve high specific activities in a more convenient, semi-automated fashion and faster time frame. Microfluidic reactors, consisting of a network of micron-sized channels (typical dimensions in the range 10 - 300¼m), filters, separation columns, electrodes and reaction loops/chambers etched onto a solid substrate, are now emerging as an extremely useful technology for the intensification and miniaturization of chemical processes. The ability to manipulate, process and analyze reagent concentrations and reaction interfaces in both space and time within the channel network of a microreactor provides the fine level of reaction control that is desirable in PET radiochemistry practice. These factors can bring radiometal labeling, specifically the preparation of radio-labeled biomolecules such as antibodies, much closer to their theoretical maximum specific activities.

  19. 新型口香糖清除器的设计%Design of New Chewing Gum Removal Equipment

    Institute of Scientific and Technical Information of China (English)

    鲁杰; 艾书义

    2012-01-01

    口香糖残留物粘着力强,易吸附灰尘和细菌,被丢弃后经日晒、踩踏,残留物与路面粘结,难以清除,严重影响城市的美观与卫生.因此口香糖残渣清理已成为环卫工作面临的重大难题.本文分析了国内口香糖残留清除方法及清除机械的现状,本着高效节能的理念,设计出一种新型半自动口香糖清除器.%Strong adhesion of chewing gum residues, easy to absorb the on the city's appearance and health, in particular, after the sun and trampl dust and bacteria, serious impact e, chewing gum residues are even more difficult to remove. Therefore, chewing gum residue removal has become a major problem facing public places. This paper analyses the domestic chewing gum residue removal methods and the current situation of removal machines, and designs a new type of chewing gum residue removal equipment.

  20. Engineered Carbon-Nanomaterial-Based Electrochemical Sensors for Biomolecules.

    Science.gov (United States)

    Tiwari, Jitendra N; Vij, Varun; Kemp, K Christian; Kim, Kwang S

    2016-01-26

    The study of electrochemical behavior of bioactive molecules has become one of the most rapidly developing scientific fields. Biotechnology and biomedical engineering fields have a vested interest in constructing more precise and accurate voltammetric/amperometric biosensors. One rapidly growing area of biosensor design involves incorporation of carbon-based nanomaterials in working electrodes, such as one-dimensional carbon nanotubes, two-dimensional graphene, and graphene oxide. In this review article, we give a brief overview describing the voltammetric techniques and how these techniques are applied in biosensing, as well as the details surrounding important biosensing concepts of sensitivity and limits of detection. Building on these important concepts, we show how the sensitivity and limit of detection can be tuned by including carbon-based nanomaterials in the fabrication of biosensors. The sensing of biomolecules including glucose, dopamine, proteins, enzymes, uric acid, DNA, RNA, and H2O2 traditionally employs enzymes in detection; however, these enzymes denature easily, and as such, enzymeless methods are highly desired. Here we draw an important distinction between enzymeless and enzyme-containing carbon-nanomaterial-based biosensors. The review ends with an outlook of future concepts that can be employed in biosensor fabrication, as well as limitations of already proposed materials and how such sensing can be enhanced. As such, this review can act as a roadmap to guide researchers toward concepts that can be employed in the design of next generation biosensors, while also highlighting the current advancements in the field. PMID:26579616

  1. 基于Django框架的设备管理系统的设计与实现%Django Framework Based Equipment Management System Design and Implementation

    Institute of Scientific and Technical Information of China (English)

    阳祝

    2013-01-01

    该文通过分析当前设备管理系统的应用场景和使用情况,将设备管理系统分解为若干模块,以用户角色为基础设计了一套完整的电子化设备管理系统。利用Python语言设计与开发了基于Django框架的设备管理系统。%This paper analyzes the current device management system applications and usage scenarios, the equipment manage-ment system is decomposed into several modules, user-role-based design of a complete set of electronic equipment management system. Design and development using the Python language Django framework based equipment management system.

  2. Design and fabrication of equipment and devices for a Radiotherapy department; Diseno y fabricacion de equipos y aditamentos para un departamento de Radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Picon, C.L.; Zaharia B, M. [Departamento de Radioterapia. Instituto de Enfermedades Neoplasicas, Av. Angamos Este 2520, Lima (Peru)

    1998-12-31

    The objective of this work is to present the possibility to design and construct utilizing local technology, a series of equipment and devices necessaries for a routine in a Radiotherapy Department with typical budget in the Latin-American hospitals. (Author)

  3. Calculation and visualization of atomistic mechanical stresses in nanomaterials and biomolecules.

    Directory of Open Access Journals (Sweden)

    Andrew T Fenley

    Full Text Available Many biomolecules have machine-like functions, and accordingly are discussed in terms of mechanical properties like force and motion. However, the concept of stress, a mechanical property that is of fundamental importance in the study of macroscopic mechanics, is not commonly applied in the biomolecular context. We anticipate that microscopical stress analyses of biomolecules and nanomaterials will provide useful mechanistic insights and help guide molecular design. To enable such applications, we have developed Calculator of Atomistic Mechanical Stress (CAMS, an open-source software package for computing atomic resolution stresses from molecular dynamics (MD simulations. The software also enables decomposition of stress into contributions from bonded, nonbonded and Generalized Born potential terms. CAMS reads GROMACS topology and trajectory files, which are easily generated from AMBER files as well; and time-varying stresses may be animated and visualized in the VMD viewer. Here, we review relevant theory and present illustrative applications.

  4. Recent trends in carbon nanomaterial-based electrochemical sensors for biomolecules: A review

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Cheng; Denno, Madelaine E.; Pyakurel, Poojan; Venton, B. Jill, E-mail: jventon@virginia.edu

    2015-08-05

    Carbon nanomaterials are advantageous for electrochemical sensors because they increase the electroactive surface area, enhance electron transfer, and promote adsorption of molecules. Carbon nanotubes (CNTs) have been incorporated into electrochemical sensors for biomolecules and strategies have included the traditional dip coating and drop casting methods, direct growth of CNTs on electrodes and the use of CNT fibers and yarns made exclusively of CNTs. Recent research has also focused on utilizing many new types of carbon nanomaterials beyond CNTs. Forms of graphene are now increasingly popular for sensors including reduced graphene oxide, carbon nanohorns, graphene nanofoams, graphene nanorods, and graphene nanoflowers. In this review, we compare different carbon nanomaterial strategies for creating electrochemical sensors for biomolecules. Analytes covered include neurotransmitters and neurochemicals, such as dopamine, ascorbic acid, and serotonin; hydrogen peroxide; proteins, such as biomarkers; and DNA. The review also addresses enzyme-based electrodes that are used to detect non-electroactive species such as glucose, alcohols, and proteins. Finally, we analyze some of the future directions for the field, pointing out gaps in fundamental understanding of electron transfer to carbon nanomaterials and the need for more practical implementation of sensors. - Highlights: • We review the types of carbon nanomaterials used in electrochemical sensors. • Different materials and sensor designs are compared for classes of biomolecules. • Future challenges of better sensor design and implementation are assessed.

  5. Biomolecule conjugation strategy using novel water-soluble phosphine-based chelating agents

    Science.gov (United States)

    Katti, Kattesh V.; Gali, Hariprasad; Volkert, Wynn A.

    2004-08-24

    This invention describes a novel strategy to produce phosphine-functionalized biomolecules (e.g. peptides or proteins) for potential use in the design and development of site-specific radiopharmaceuticals for diagnosis or therapy of specific cancers. Hydrophilic alkyl phosphines, in general, tend to be oxidatively unstable. Therefore, incorporation of such phosphine functionalities on peptide (and other biomolecule) backbones, without oxidizing the P.sup.III centers, is difficult. In this context this discovery reports on a new technology by which phosphines, in the form of bifunctional chelating agents, can be directly incorporated on biomolecular backbones using manual synthetic or solid phase peptide synthesis methodologies. The superior ligating abilities of phosphine ligands, with various diagnostically (e.g. TC-99m) or therapeutically (e.g. Re186/188, Rh-105, Au-199) useful radiometals, coupled with the findings that the resulting complexes demonstrate high in vivo stability makes this approach useful in the development of radiolabeled biomolecules for applications in the design of tumor-specific radiopharmaceuticals.

  6. Recent trends in carbon nanomaterial-based electrochemical sensors for biomolecules: A review

    International Nuclear Information System (INIS)

    Carbon nanomaterials are advantageous for electrochemical sensors because they increase the electroactive surface area, enhance electron transfer, and promote adsorption of molecules. Carbon nanotubes (CNTs) have been incorporated into electrochemical sensors for biomolecules and strategies have included the traditional dip coating and drop casting methods, direct growth of CNTs on electrodes and the use of CNT fibers and yarns made exclusively of CNTs. Recent research has also focused on utilizing many new types of carbon nanomaterials beyond CNTs. Forms of graphene are now increasingly popular for sensors including reduced graphene oxide, carbon nanohorns, graphene nanofoams, graphene nanorods, and graphene nanoflowers. In this review, we compare different carbon nanomaterial strategies for creating electrochemical sensors for biomolecules. Analytes covered include neurotransmitters and neurochemicals, such as dopamine, ascorbic acid, and serotonin; hydrogen peroxide; proteins, such as biomarkers; and DNA. The review also addresses enzyme-based electrodes that are used to detect non-electroactive species such as glucose, alcohols, and proteins. Finally, we analyze some of the future directions for the field, pointing out gaps in fundamental understanding of electron transfer to carbon nanomaterials and the need for more practical implementation of sensors. - Highlights: • We review the types of carbon nanomaterials used in electrochemical sensors. • Different materials and sensor designs are compared for classes of biomolecules. • Future challenges of better sensor design and implementation are assessed

  7. Observer-Based State-Space Current Controller for a Grid Converter Equipped With an LCL Filter: Analytical Method for Direct Discrete-Time Design

    OpenAIRE

    Kukkola, Jarno; Hinkkanen, Marko; Zenger, Kai

    2015-01-01

    State-space current control enables high dynamic performance of a three-phase grid-connected converter equipped with an LCL filter. In this paper, observer-based state-space control is designed using direct pole placement in the discrete-time domain and in grid-voltage coordinates. Analytical expressions for the controller and observer gains are derived as functions of the physical system parameters and design specifications. The connection between the physical parameters and the control algor...

  8. Space Heating Equipment

    Energy Technology Data Exchange (ETDEWEB)

    Rafferty, Kevin D.

    1998-01-01

    The performance evaluation of space heating equipment for a geothermal application is generally considered from either of two perspectives: (a) selecting equipment for installation in new construction, or (b) evaluating the performance and retrofit requirements of an existing system. With regard to new construction, the procedure is relatively straightforward. Once the heating requirements are determined, the process need only involve the selection of appropriately sized hot water heating equipment based on the available water temperature. It is important to remember that space heating equipment for geothermal applications is the same equipment used in non-geothermal applications. What makes geothermal applications unique is that the equipment is generally applied at temperatures and flow rates that depart significantly from traditional heating system design. This chapter presents general considerations for the performance of heating equipment at non-standard temperature and flow conditions, retrofit of existing systems, and aspects of domestic hot water heating.

  9. Active immobilization of biomolecules on a hybrid three-dimensional nanoelectrode by dielectrophoresis for single-biomolecule study

    International Nuclear Information System (INIS)

    We propose and experimentally demonstrate a method of active immobilization for biomolecules on a three-dimensional nanometre-scale electrode (3D nanoelectrode) using dielectrophoresis to immobilize the biomolecules at predetermined locations for single-biomolecule study. We have developed a novel two-step fabrication process for obtaining a 3D nanoelectrode having a sharp top, which is necessary for immobilizing a single biomolecule at a single point. The first step is to fabricate the backbone structure, which is rigid and defines the shape of the 3D nanoelectrode. It was fabricated with diamond-like carbon (DLC) obtained using focused ion beam assisted chemical vapour deposition followed by post-plasma etching, which reshapes the DLC structure. The second step coats the DLC structure with a thin layer of aluminium, which supplies electrical conductivity to the DLC structure. By applying a high frequency (of the order of megahertz) and high intensity (greater than or equal to a few megavolts per metre) electric field using the 3D nanoelectrodes, the generated dielectrophoresis attracted and then immobilized target biomolecules onto the tops of 3D nanoelectrodes, as a demonstration of active immobilization of biomolecules

  10. Diagnostic and therapeutic perspectives in nuclear medicine: radiolabelled biomolecules

    International Nuclear Information System (INIS)

    From their beginning, the radiopharmaceuticals chemistry has gone to the study of the molecular chemistry. The radiopharmaceuticals are only in their capacity to detect such specific biochemical places as the receivers and the enzymes. With the recent obtaining of the complete structural sequence of the genome, it doesn't fit doubt of the importance that they have acquired the molecular images for the study from the genetic information to the alterations phenotypic in the chemistry of the human body. So, the future of the diagnostic and therapeutic nuclear medicine, practically is based in the study of protein fragments, peptide structures and chains of DNA radiolabelled for the study of the metabolism In vivo. These investigations represent a substantial change in those paradigms of the pharmaceutical development, when using the own organic capacities as source of medications, instead of considering to the organism like a simple assay tube where molecules act, like they are most of the traditional medications. The investigation of new techniques to design complex stable of Tc-99m, Re-188, Lu-177, Y-90 and Dy-166/Ho-l66 with biomolecules that don't alter the specificity and in general the molecular properties of the same ones. it is a topic of world interest in the environment of the radiopharmaceutical chemistry. In this work some achievements and perspectives are presented on those main diagnostic and therapeutic radiopharmaceuticals of third generation. (Author)

  11. Research, Calculation for Designing the Technological Equipment Line of Cementation with 3,000 Tonnes of Solid Waste/Year Capacity for ZOC Plan

    International Nuclear Information System (INIS)

    Technological process and equipment line for cementation with 3,000 tons of solid wastes/year capacity for ZOC plant was studied according to the quantity, the composition and the property of solid wastes from ZOC plant. The influence of several parameters with cementation process such as cement mixing ratio, size, moisture and NaCl content in residue, which affected to mechanical and chemical strength of waste block after cementation was evaluated. The calculation and designing for cementation equipment line were thus conducted and total investment cost of construction and installation as well as operation of this equipment line was also estimated. Radiation safety and environmental protection for waste treatment facility was calculated and the design on radiation safety and environmental protection for equipment line was proposed. Technological process and design document of this production line seemed to be reasonable because it is consistent with properties of wastes as well as it has been commonly used in the world to stabilize solid residues in nuclear industry. The advantages of this propose were simple structure of the devices, locally made, easy operation, locally available and inexpensive materials resulting in low cost of investment and operation. (author)

  12. Cooling of electronic equipment

    DEFF Research Database (Denmark)

    A. Kristensen, Anders Schmidt

    2003-01-01

    Cooling of electronic equipment is studied. The design size of electronic equipment decrease causing the thermal density to increase. This affect the cooling which can cause for example failures of critical components due to overheating or thermal induced stresses. Initially a pin fin heat sink...

  13. Production of biomolecule microarrays through laser induced forward transfer

    Science.gov (United States)

    Fernandez-Pradas, Juan Marcos; Serra, Pere; Colina, Monica; Morenza, Jose-Luis

    2004-10-01

    Biomolecule microarrays are a kind of biosensors that consist in patterns of different biological molecules immobilized on a solid substrate and capable to bind specifically to their complementary targets. In particular, DNA and protein microarrays have been revealed to be very efficient devices for genen and protein identification, what has converted them in powerful tools for many applications, like clinical diagnose, drug discovery analysis, genomics and proteomics. The production of these devices requires the manipulation of tiny amounts of a liquid solution containing biomolecules without damaging them. In this work laser induced forward transfer (LIFT) has been used for spotting a biomolecule in order to check the viability of this technique for the production of microarrays. A pulsed Nd:YAG laser beam (355 nm wavelength) has been used to transfer droplets of a biomolecule containing solution onto a solid slide. Optical microscopy of the transferred material has been carried out to investigate the morphological characteristics of the droplets obtained under different irradiation conditions. Afterwards, a DNA microarray has been spotted. The viability of the transference has been tested by checking the biological activity of the biomolecule in front of its specific complementary target. This has revealed that, indeed, the LIFT technique is adequate for the production of DNA microarrays.

  14. Design and Realization of Integrated Management System for Data Interoperability between Point-of-Care Testing Equipment and Hospital Information System

    Science.gov (United States)

    Park, Ki Sang; Heo, Hyuk

    2013-01-01

    Objectives The purpose of this study was to design an integrated data management system based on the POCT1-A2, LIS2-A, LIS2-A2, and HL7 standard to ensure data interoperability between mobile equipment, such as point-of-care testing equipment and the existing hospital data system, its efficiency was also evaluated. Methods The method of this study was intended to design and realize a data management system which would provide a solution for the problems that occur when point-of-care testing equipment is introduced to existing hospital data, after classifying such problems into connectivity, integration, and interoperability. This study also checked if the data management system plays a sufficient role as a bridge between the point-of-care testing equipment and the hospital information system through connection persistence and reliability testing, as well as data integration and interoperability testing. Results In comparison with the existing system, the data management system facilitated integration by improving the result receiving time, improving the collection rate, and by enabling the integration of disparate types of data into a single system. And it was found out that we can solve the problems related to connectivity, integration and interoperability through generating the message in standardized types. Conclusions It is expected that the proposed data management system, which is designed to improve the integration point-of-care testing equipment with existing systems, will establish a solid foundation on which better medical service may be provided by hospitals by improving the quality of patient service. PMID:24175121

  15. Operating Sulfiban desulfurization equipment

    Energy Technology Data Exchange (ETDEWEB)

    Kato, T.; Sekikawa, N.; Matsumura, S.; Tawara, T.

    1982-01-01

    A report on the equipment referred to in the title, which has been operating smoothly during the two years since its construction at the Keihin Iron Works. The flowsheet of the Sulfiban process is outlined, with explanations of the design conditions, equipment characteristics, and operational record. Coke oven gas is brought into contact with a 15% solution of monoethanolamine in the desulfurization tower and the contained H/sub 2/S, HCN and some of the CO/sub 2/ is removed by absorption. The equipment maintains a high desulfurization percentage of over 97%. Corrosion control of the equipment is touched upon.

  16. Generalized design of fitness equipment control interface%健身器材控制界面的通用化设计

    Institute of Scientific and Technical Information of China (English)

    林能涛; 苏智剑; 乔帅; 闫扬义; 闫勇杰

    2014-01-01

    BACKGROUND:Health has been paid more and more attention in modern society, the health of those special groups, such as the elderly and the disabled, should also be brought to the forefront. As fitness equipment is more and more popular in contemporary, our focus should be transferred to the use of fitness equipment for these special groups. OBJECTIVE:To put forward the design strategy of fitness equipment control interface, for the special groups to use common fitness equipment comfortably and conveniently. METHODS:Based on the research of existing fitness equipment control interface, according to the usage habits and cognitive awareness of special groups on control interface, a new design strategy has been put forward using the general design method and ergonomics. RESULTS AND CONCLUSION:Based on the existing 45 kinds of exercise bikes, 84 kinds of running machines and 129 kinds of treadmil fitness equipments, we found that these equipments are designed for common users in the aspects of design and production process and control interface. Universal design is a design concept beyond the lack of capacity to meet the different needs of different populations, and designed products can reduce or even eliminate the difference in the ability of special populations and the general population in use. The new strategy makes design of fitness equipment control interface generalized and good man-machine interactive, which can meet the demand of the special groups and help them do fitness exercise to improve their health and body function.%背景:随着健身器材越来越普及的当代国情,关注的焦点也应该转移到老年人、残疾人等这些特殊群体对健身器材的使用上。  目的:提出健身器材控制界面通用化设计策略,以便于特殊人群能够舒适方便的使用普通健身器材。  方法:通过对现有健身器材控制界面的调查研究,结合特殊人群对控制界面的使用习惯和认知意识,

  17. 健身器材控制界面的通用化设计%Generalized design of fitness equipment control interface

    Institute of Scientific and Technical Information of China (English)

    林能涛; 苏智剑; 乔帅; 闫扬义; 闫勇杰

    2014-01-01

    BACKGROUND:Health has been paid more and more attention in modern society, the health of those special groups, such as the elderly and the disabled, should also be brought to the forefront. As fitness equipment is more and more popular in contemporary, our focus should be transferred to the use of fitness equipment for these special groups. OBJECTIVE:To put forward the design strategy of fitness equipment control interface, for the special groups to use common fitness equipment comfortably and conveniently. METHODS:Based on the research of existing fitness equipment control interface, according to the usage habits and cognitive awareness of special groups on control interface, a new design strategy has been put forward using the general design method and ergonomics. RESULTS AND CONCLUSION:Based on the existing 45 kinds of exercise bikes, 84 kinds of running machines and 129 kinds of treadmil fitness equipments, we found that these equipments are designed for common users in the aspects of design and production process and control interface. Universal design is a design concept beyond the lack of capacity to meet the different needs of different populations, and designed products can reduce or even eliminate the difference in the ability of special populations and the general population in use. The new strategy makes design of fitness equipment control interface generalized and good man-machine interactive, which can meet the demand of the special groups and help them do fitness exercise to improve their health and body function.%背景:随着健身器材越来越普及的当代国情,关注的焦点也应该转移到老年人、残疾人等这些特殊群体对健身器材的使用上。  目的:提出健身器材控制界面通用化设计策略,以便于特殊人群能够舒适方便的使用普通健身器材。  方法:通过对现有健身器材控制界面的调查研究,结合特殊人群对控制界面的使用习惯和认知意识,

  18. Enzymatic Ligation of Large Biomolecules to DNA

    DEFF Research Database (Denmark)

    Sørensen, Rasmus Schøler; Okholm, Anders Hauge; Schaffert, David Henning; Kodal, Anne Louise Bank; Gothelf, Kurt Vesterager; Kjems, Jørgen

    2013-01-01

    application. However, conjugation of DNA to large molecular components using classical chemistries often suffers from suboptimal yields. Here, we report the use of terminal deoxynucleotidyl transferase (TdT) for direct enzymatic ligation of native DNA to nucleotide triphosphates coupled to proteins and other...... self-assembled structures, antisense therapeutics, microarray diagnostics, and biosensors. Such applications frequently require DNA to be modified and conjugated to other macromolecules, including proteins, polymers, or fatty acids, in order to equip the system with properties required for a particular...

  19. RETRIEVAL EQUIPMENT DESCRIPTIONS

    International Nuclear Information System (INIS)

    The objective and the scope of this document are to list and briefly describe the major mobile equipment necessary for waste package (WP) retrieval from the proposed subsurface nuclear waste repository at Yucca Mountain. Primary performance characteristics and some specialized design features of the equipment are explained and summarized in the individual subsections of this document. There are no quality assurance requirements or QA controls in this document. Retrieval under normal conditions is accomplished with the same fleet of equipment as is used for emplacement. Descriptions of equipment used for retrieval under normal conditions is found in Emplacement Equipment Descriptions, DI: BCAF00000-01717-5705-00002 (a document in progress). Equipment used for retrieval under abnormal conditions is addressed in this document and consists of the following: (1) Inclined Plane Hauler; (2) Bottom Lift Transporter; (3) Load Haul Dump (LHD) Loader; (4) Heavy Duty Forklift for Emplacement Drifts; (5) Covered Shuttle Car; (6) Multipurpose Vehicle; and (7) Scaler

  20. Redefinition of Space and Equipment in the Kindergarten and Involving the Children in the Process of Designing.

    Science.gov (United States)

    Bika, Anastasia

    This research examined the extent to which 2.5- to 5-year-old children in three Kindergarten classrooms in Thessaloniki, Greece could be taught about the use of classroom space and equipment. The study combined the theoretical perspectives of Piaget, Vygotsky, Bruner, and Frangos with the views of theater director Peter Brook. Mixed-age groups of…

  1. 某型导弹发控设备自动测试系统设计%Design of missile inertial guidance equipment automatic test system

    Institute of Scientific and Technical Information of China (English)

    杨艾兵; 董洋; 林园; 彭伟

    2012-01-01

    阐述了某型导弹发控设备自动测试系统的设计思想、硬件组成和软件设计。系统采用基于网络数据采集卡的虚拟仪器结构,实现了对某型导弹发控设备的自动测试,具有较高的可靠性、可雏修性和良好的使用性。%This paper describes a type of missile launch and control equipment, automatic test system design, hardware components and software design. System uses a Web-based virtual instrument data acquisition card of the structure, the realization of a missile launch and control equipment, automatic test, with high reliability, maintainability and good usability.

  2. Constraint methods that accelerate free-energy simulations of biomolecules

    International Nuclear Information System (INIS)

    Atomistic molecular dynamics simulations of biomolecules are critical for generating narratives about biological mechanisms. The power of atomistic simulations is that these are physics-based methods that satisfy Boltzmann’s law, so they can be used to compute populations, dynamics, and mechanisms. But physical simulations are computationally intensive and do not scale well to the sizes of many important biomolecules. One way to speed up physical simulations is by coarse-graining the potential function. Another way is to harness structural knowledge, often by imposing spring-like restraints. But harnessing external knowledge in physical simulations is problematic because knowledge, data, or hunches have errors, noise, and combinatoric uncertainties. Here, we review recent principled methods for imposing restraints to speed up physics-based molecular simulations that promise to scale to larger biomolecules and motions

  3. Kinetic analysis of interaction between lipopolysaccharide and biomolecules

    Institute of Scientific and Technical Information of China (English)

    Fan YANG; Xiurong YANG

    2008-01-01

    Lipopolysaccharide (LPS) is a major compo-nent of the outer membrane of all gram-negative bacteria. It interacts with some biomolecules and triggers a toxic reaction. In this paper, we studied the interaction between LPS from Salmonella Minnesota and some biomolecules using a surface plasmon resonance (SPR) biosensor. Biomolecules were immobilized on a CM5 sensor chip using the amino coupling method and LPS was injected over the immobilized surfaces. The affinity constant KA of LPS with serum albumin, hemoglobin, chitosan and lysozyme was 2.36 × 107, 2.03 × 108,7.58×106, 2.82 × 104 L·mol-1, respectively. However, LPS could not interact with ferritin.

  4. Identification of biomolecules by terahertz spectroscopy and fuzzy pattern recognition

    Science.gov (United States)

    Chen, Tao; Li, Zhi; Mo, Wei

    2013-04-01

    An approach for automatic identification of terahertz (THz) spectra of biomolecules is proposed based on principal component analysis (PCA) and fuzzy pattern recognition in this paper, and THz transmittance spectra of some typical amino acid and saccharide biomolecular samples are investigated to prove its feasibility. Firstly, PCA is applied to reduce the dimensionality of the original spectrum data and extract features of the data. Secondly, instead of the original spectrum variables, the selected principal component scores matrix is fed into the model of fuzzy pattern recognition, where a principle of fuzzy closeness based optimization is employed to identify those samples. Results demonstrate that THz spectroscopy combined with PCA and fuzzy pattern recognition can be efficiently utilized for automatic identification of biomolecules. The proposed approach provides a new effective method in the detection and identification of biomolecules using THz spectroscopy.

  5. Constraint methods that accelerate free-energy simulations of biomolecules

    Energy Technology Data Exchange (ETDEWEB)

    Perez, Alberto [Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, New York 11794 (United States); MacCallum, Justin L. [Department of Chemistry, University of Calgary, Calgary, Alberta T2N 1N4 (Canada); Coutsias, Evangelos A. [Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, New York 11794 (United States); Department of Applied Mathematics, Stony Brook University, Stony Brook, New York 11794 (United States); Dill, Ken A. [Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, New York 11794 (United States); Department of Physics and Astronomy, Stony Brook University, Stony Brook, New York 11794 (United States)

    2015-12-28

    Atomistic molecular dynamics simulations of biomolecules are critical for generating narratives about biological mechanisms. The power of atomistic simulations is that these are physics-based methods that satisfy Boltzmann’s law, so they can be used to compute populations, dynamics, and mechanisms. But physical simulations are computationally intensive and do not scale well to the sizes of many important biomolecules. One way to speed up physical simulations is by coarse-graining the potential function. Another way is to harness structural knowledge, often by imposing spring-like restraints. But harnessing external knowledge in physical simulations is problematic because knowledge, data, or hunches have errors, noise, and combinatoric uncertainties. Here, we review recent principled methods for imposing restraints to speed up physics-based molecular simulations that promise to scale to larger biomolecules and motions.

  6. Understanding small biomolecule-biomaterial interactions: a review of fundamental theoretical and experimental approaches for biomolecule interactions with inorganic surfaces.

    Science.gov (United States)

    Costa, Dominique; Garrain, Pierre-Alain; Baaden, Marc

    2013-04-01

    Interactions between biomolecules and inorganic surfaces play an important role in natural environments and in industry, including a wide variety of conditions: marine environment, ship hulls (fouling), water treatment, heat exchange, membrane separation, soils, mineral particles at the earth's surface, hospitals (hygiene), art and buildings (degradation and biocorrosion), paper industry (fouling) and more. To better control the first steps leading to adsorption of a biomolecule on an inorganic surface, it is mandatory to understand the adsorption mechanisms of biomolecules of several sizes at the atomic scale, that is, the nature of the chemical interaction between the biomolecule and the surface and the resulting biomolecule conformations once adsorbed at the surface. This remains a challenging and unsolved problem. Here, we review the state of art in experimental and theoretical approaches. We focus on metallic biomaterial surfaces such as TiO(2) and stainless steel, mentioning some remarkable results on hydroxyapatite. Experimental techniques include atomic force microscopy, surface plasmon resonance, quartz crystal microbalance, X-ray photoelectron spectroscopy, fluorescence microscopy, polarization modulation infrared reflection absorption spectroscopy, sum frequency generation and time of flight secondary ion mass spectroscopy. Theoretical models range from detailed quantum mechanical representations to classical forcefield-based approaches. PMID:23015529

  7. Quantum chemistry and charge transport in biomolecules with superconducting circuits

    Science.gov (United States)

    García-Álvarez, L.; Las Heras, U.; Mezzacapo, A.; Sanz, M.; Solano, E.; Lamata, L.

    2016-06-01

    We propose an efficient protocol for digital quantum simulation of quantum chemistry problems and enhanced digital-analog quantum simulation of transport phenomena in biomolecules with superconducting circuits. Along these lines, we optimally digitize fermionic models of molecular structure with single-qubit and two-qubit gates, by means of Trotter-Suzuki decomposition and Jordan-Wigner transformation. Furthermore, we address the modelling of system-environment interactions of biomolecules involving bosonic degrees of freedom with a digital-analog approach. Finally, we consider gate-truncated quantum algorithms to allow the study of environmental effects.

  8. Quantum chemistry and charge transport in biomolecules with superconducting circuits

    Science.gov (United States)

    García-Álvarez, L.; Las Heras, U.; Mezzacapo, A.; Sanz, M.; Solano, E.; Lamata, L.

    2016-01-01

    We propose an efficient protocol for digital quantum simulation of quantum chemistry problems and enhanced digital-analog quantum simulation of transport phenomena in biomolecules with superconducting circuits. Along these lines, we optimally digitize fermionic models of molecular structure with single-qubit and two-qubit gates, by means of Trotter-Suzuki decomposition and Jordan-Wigner transformation. Furthermore, we address the modelling of system-environment interactions of biomolecules involving bosonic degrees of freedom with a digital-analog approach. Finally, we consider gate-truncated quantum algorithms to allow the study of environmental effects. PMID:27324814

  9. Design and realization of test system for testing parallelism and jumpiness of optical axis of photoelectric equipment

    Science.gov (United States)

    Shi, Sheng-bing; Chen, Zhen-xing; Qin, Shao-gang; Song, Chun-yan; Jiang, Yun-hong

    2014-09-01

    With the development of science and technology, photoelectric equipment comprises visible system, infrared system, laser system and so on, integration, information and complication are higher than past. Parallelism and jumpiness of optical axis are important performance of photoelectric equipment,directly affect aim, ranging, orientation and so on. Jumpiness of optical axis directly affect hit precision of accurate point damage weapon, but we lack the facility which is used for testing this performance. In this paper, test system which is used fo testing parallelism and jumpiness of optical axis is devised, accurate aim isn't necessary and data processing are digital in the course of testing parallelism, it can finish directly testing parallelism of multi-axes, aim axis and laser emission axis, parallelism of laser emission axis and laser receiving axis and first acuualizes jumpiness of optical axis of optical sighting device, it's a universal test system.

  10. The increased safety level for structures, equipment and pipe networks by use of shock, vibration and seismic damping mechanical devices as per SERB -CITON design

    International Nuclear Information System (INIS)

    The paper presents SERB - SITON solution to reduce shocks, vibration and seismic movements in structures, pipe networks and equipment. The elimination or reduction of vibration is a difficult problem, still improperly handled theoretically and practically because the existing supports and dampers cannot provide a satisfactory damping for all the frequency ranges in the technical domain. The stiffness and damping of classic supports do not allow a good isolation against shocks and vibrations. In order to reduce the effects of vibrations with equipment and pipe network, this paper presents the results obtained by SITON on the concept, design, construction experimental testing and application of new types of supports called 'SERB Supports or devices'. These supports which include sandwich type elements, made up of elastic blade packages with distortions controlled by central and peripheral rigid parts are not affected by the aging phenomenon. The new types of supports may adjust themselves to the level of stress and distortion at overloading due to their non - linear geometric behavior while the contact pressure between the blades is limited to pre - set values. Due to their characteristics of adjustment to the actual position and level of stress, to the installation computation errors, the new supports show minimal effects on the pipe network and equipment stress condition. Herein below it is a presentation of the results obtained by SITON in the isolation of heavy equipment and pipe networks. (authors)

  11. Modelling of the WWER-440 type reactor emergency conditions associated with a pipeline breakage while training equipment designing

    International Nuclear Information System (INIS)

    A theoretical investigation of the emergency conditions connected with the rupture of 500 mm dia main circulating pipe of the primary circuit of the WWER-440 type reactor nuclear power plant has been carried out. The calculations have been performed using the ''''Minsk-32'' digital computer. A method is described of data presentation in the form suitable for modelling of transients in conformity with the training equipment

  12. Design and Contruction Rules for Mechanical equipments of PWR islands: RCC-M. Tome 3: test methods

    International Nuclear Information System (INIS)

    This book is the 6th of a whole set of 7 ones which constitute the edition 1985 of the RCC-M. The present book deals with test methods: mechanical, physical, physico-chemical and chemical tests (tensile test, impact test, toughness test, folding test, flaring and flattening test, hardness test...; accelerated intergranular corrosion test, structure examination, measurement of the ferrite ratio, chemical composition control, test to estimate residual stresses in exchanger tubes); ultrasonic testing (equipments and modalities, examination of castings forgings, sheet metals, tubes, welded joints, coatings and platings); radiographic tests/equipments and processes, film processing, examination and quality, examination of castings and forgings and of welded joints); liquid penetrant testing (products used and processes, examination and interpretation, cleaning); magnetoscopic examinations (equipments and modalities, interpretation, cleaning and demagnetization, current passage test by means of portable electric control, magnetic flux passage test, and Eddy current testing for tubular elements); and several other examinations (visual, surface state, leak testing). The qualification and certification of non-destructif testing operators is finally dealt with

  13. Recovery of Biomolecules from Food Wastes — A Review

    Directory of Open Access Journals (Sweden)

    Antonietta Baiano

    2014-09-01

    Full Text Available Food wastes are produced by a variety of sources, ranging from agricultural operations to household consumption. About 38% occurs during food processing. At present, the European Union legislation encourages the exploitation of co-products. This valorisation can be achieved through the extraction of high-value components such as proteins, polysaccharides, fibres, flavour compounds, and phytochemicals, which can be re-used as nutritionally and pharmacologically functional ingredients. Extraction can proceed according to solid-liquid extraction, Soxhlet extraction, pressurized fluid extraction, supercritical fluid extraction, ultrasound-assisted extraction, microwave-assisted extraction, pulsed electric field extraction, and enzyme-assisted extraction. Nevertheless, these techniques cannot be used indiscriminately and their choice depends on the type of biomolecules and matrix, the scale processing (laboratory or industrial, the ratio between production costs and economic values of the compounds to be extracted. The vegetable wastes include trimmings, peelings, stems, seeds, shells, bran, residues remaining after extraction of oil, starch, sugar, and juice. The animal-derived wastes include wastes from bred animals, wastes from seafood, wastes from dairy processing. The recovered biomolecules and by-products can be used to produce functional foods or as adjuvants in food processing or in medicinal and pharmaceutical preparations. This work is an overview of the type and amounts of food wastes; food waste legislation; conventional and novel techniques suitable for extracting biomolecules; food, medicinal and pharmaceutical uses of the recovered biomolecules and by-products, and future trends in these areas.

  14. Photochemical Microscale Electrophoresis Allows Fast Quantification of Biomolecule Binding.

    Science.gov (United States)

    Möller, Friederike M; Kieß, Michael; Braun, Dieter

    2016-04-27

    Intricate spatiotemporal patterns emerge when chemical reactions couple to physical transport. We induce electrophoretic transport by a confined photochemical reaction and use it to infer the binding strength of a second, biomolecular binding reaction under physiological conditions. To this end, we use the photoactive compound 2-nitrobenzaldehyde, which releases a proton upon 375 nm irradiation. The charged photoproducts locally perturb electroneutrality due to differential diffusion, giving rise to an electric potential Φ in the 100 μV range on the micrometer scale. Electrophoresis of biomolecules in this field is counterbalanced by back-diffusion within seconds. The biomolecule concentration is measured by fluorescence and settles proportionally to exp(-μ/D Φ). Typically, binding alters either the diffusion coefficient D or the electrophoretic mobility μ. Hence, the local biomolecule fluorescence directly reflects the binding state. A fit to the law of mass action reveals the dissociation constant of the binding reaction. We apply this approach to quantify the binding of the aptamer TBA15 to its protein target human-α-thrombin and to probe the hybridization of DNA. Dissociation constants in the nanomolar regime were determined and match both results in literature and in control experiments using microscale thermophoresis. As our approach is all-optical, isothermal and requires only nanoliter volumes at nanomolar concentrations, it will allow for the fast screening of biomolecule binding in low volume multiwell formats. PMID:27042755

  15. Recovery of biomolecules from food wastes--a review.

    Science.gov (United States)

    Baiano, Antonietta

    2014-01-01

    Food wastes are produced by a variety of sources, ranging from agricultural operations to household consumption. About 38% occurs during food processing. At present, the European Union legislation encourages the exploitation of co-products. This valorisation can be achieved through the extraction of high-value components such as proteins, polysaccharides, fibres, flavour compounds, and phytochemicals, which can be re-used as nutritionally and pharmacologically functional ingredients. Extraction can proceed according to solid-liquid extraction, Soxhlet extraction, pressurized fluid extraction, supercritical fluid extraction, ultrasound-assisted extraction, microwave-assisted extraction, pulsed electric field extraction, and enzyme-assisted extraction. Nevertheless, these techniques cannot be used indiscriminately and their choice depends on the type of biomolecules and matrix, the scale processing (laboratory or industrial), the ratio between production costs and economic values of the compounds to be extracted. The vegetable wastes include trimmings, peelings, stems, seeds, shells, bran, residues remaining after extraction of oil, starch, sugar, and juice. The animal-derived wastes include wastes from bred animals, wastes from seafood, wastes from dairy processing. The recovered biomolecules and by-products can be used to produce functional foods or as adjuvants in food processing or in medicinal and pharmaceutical preparations. This work is an overview of the type and amounts of food wastes; food waste legislation; conventional and novel techniques suitable for extracting biomolecules; food, medicinal and pharmaceutical uses of the recovered biomolecules and by-products, and future trends in these areas. PMID:25232705

  16. Fullerene–biomolecule conjugates and their biomedicinal applications

    Directory of Open Access Journals (Sweden)

    Yang X

    2013-12-01

    Full Text Available Xinlin Yang,1 Ali Ebrahimi,1 Jie Li,1,2 Quanjun Cui11Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA; 2School of Materials Science, Beijing Institute of Technology, Beijing, People's Republic of ChinaAbstract: Fullerenes are among the strongest antioxidants and are characterized as "radical sponges." The research on biomedicinal applications of fullerenes has achieved significant progress since the landmark publication by Friedman et al in 1993. Fullerene–biomolecule conjugates have become an important area of research during the past 2 decades. By a thorough literature search, we attempt to update the information about the synthesis of different types of fullerene–biomolecule conjugates, including fullerene-containing amino acids and peptides, oligonucleotides, sugars, and esters. Moreover, we also discuss in this review recently reported data on the biological and pharmaceutical utilities of these compounds and some other fullerene derivatives of biomedical importance. While within the fullerene–biomolecule conjugates, in which fullerene may act as both an antioxidant and a carrier, specific targeting biomolecules conjugated to fullerene will undoubtedly strengthen the delivery of functional fullerenes to sites of clinical interest.Keywords: fullerene, amino acid, peptide, oligonucleotide, sugar, ester

  17. Solvation dynamics of biomolecules: modeling and terahertz experiments.

    Science.gov (United States)

    Leitner, David M; Gruebele, Martin; Havenith, Martina

    2008-12-01

    The role of water in biomolecule dynamics has attracted much interest over the past decade, due in part to new probes of biomolecule-water interactions and developments in molecular simulations. Terahertz (THz) spectroscopy, among the most recent experimental methods brought to bear on this problem, is able to detect even small solute induced changes of the collective water network dynamics at the biomolecule-water interface. THz measurements reveal that proteins influence up to 1000 water molecules in their surroundings, and that even small saccharides influence the dynamics of hundreds of surrounding water molecules. The THz spectrum of a protein is sensitive to mutation and depends on the surface charge and flexibility of the protein. Influence on the solvation shell appears most pronounced for native wildtype proteins and decreases upon partial unfolding or mutation. THz spectra of solvated saccharides reveal that the number of water molecules coupled dynamically to a saccharide, forming a dynamical hydration shell around it, is related to the number of exposed oxygen atoms on the solute. The thickness of this layer appears correlated with the bioprotection efficiency of the saccharide. All findings support the thesis of a long-range dynamic coupling between biomolecule and solvent. PMID:19436490

  18. Work Breakdown Structure and Plant/Equipment Designation System Numbering Scheme for the High Temperature Gas- Cooled Reactor (HTGR) Component Test Capability (CTC)

    Energy Technology Data Exchange (ETDEWEB)

    Jeffrey D Bryan

    2009-09-01

    This white paper investigates the potential integration of the CTC work breakdown structure numbering scheme with a plant/equipment numbering system (PNS), or alternatively referred to in industry as a reference designation system (RDS). Ideally, the goal of such integration would be a single, common referencing system for the life cycle of the CTC that supports all the various processes (e.g., information, execution, and control) that necessitate plant and equipment numbers be assigned. This white paper focuses on discovering the full scope of Idaho National Laboratory (INL) processes to which this goal might be applied as well as the factors likely to affect decisions about implementation. Later, a procedure for assigning these numbers will be developed using this white paper as a starting point and that reflects the resolved scope and outcome of associated decisions.

  19. 21 CFR 225.30 - Equipment.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Equipment. 225.30 Section 225.30 Food and Drugs... Equipment § 225.30 Equipment. (a) Equipment which is designed to perform its intended function and is properly installed and used is essential to the manufacture of medicated feeds. Such equipment...

  20. The Development of Computer-Aided Design for Electrical Equipment Selection and Arrangement of 10 Kv Switchgear

    OpenAIRE

    Chernaya Anastassiya; Sokolova Elvira

    2015-01-01

    The paper intends to give an overview of a computer-aided design program application. The research includes two main parts: the development of a computer-aided design for an appropriate switchgear selection and its arrangement in an indoor switchgear layout. Matlab program was used to develop a computer-aided design system. The use of this program considerably simplifies the selection and arrangement of 10 kV switchgear.

  1. Site characterization and validation - equipment design and techniques used in single borehole hydraulic testing, simulated drift experiment and crosshole testing

    International Nuclear Information System (INIS)

    This report describes the equipment and techniques used to investigate the variation of hydrogeological parameters within a fractured crystalline rock mass. The testing program was performed during stage 3 of the site characterization and validation programme at the Stripa mine in Sweden. This programme used a multidisciplinary approach, combining geophysical, geological and hydrogeological methods, to determine how groundwater moved through the rock mass. The hydrogeological work package involved three components. Firstly, novel single borehole techniques (focused packer testing) were used to determine the distribution of hydraulic conductivity and head along individual boreholes. Secondly, water was abstracted from boreholes which were drilled to simulate a tunnel (simulated drift experiment). Locations and magnitudes of flows were measured together with pressure responses at various points in the SCV rock mass. Thirdly, small scale crosshole tests, involving detailed interference testing, were used to determine the variability of hydrogeological parameters within previously identified, significant flow zones. (au)

  2. Database design on accounting treatment system for music equipment management%音乐器材管理账务处理系统数据库设计

    Institute of Scientific and Technical Information of China (English)

    吕欣鑫

    2014-01-01

    音乐教育是我国素质教育的重要组成部分,提高学生的音乐艺术素养,必须充分发挥音乐器材的重要作用。针对音乐器材账务难以管理的现状,本文进行数据库设计,为账务处理系统开发提供支持。以需求分析为基础,进行了概念结构设计和逻辑结构设计。需求分析采用UML进行用例建模,概念结构设计采用实体联系图表示,逻辑结构设计以转换规则为基础通过表格形式设计了3个表结构。%Music education is an important part of quality education,which can improve their music art accomplishment,so the important role of music equipment must be fully play.This paper studies database design in the light of the present situation of music equipment accounting difficult to manage to provide support for the development of accounting treatment system.Conceptual structure design and logical structure design should be carried on based on requirement analysis.Requirement analysis conducted use case modeling used UML;conceptual structure design was showed by the diagram of entity-relationship;logical structure design designed three table structures by the table form based on transformation rule.

  3. Meteorology Electronic Equipment Test and Network System Design%气象电子设备检修及网络系统设计

    Institute of Scientific and Technical Information of China (English)

    秦铁

    2009-01-01

    计算机技术和信息技术在我国气象业务中的开发与应用已日益广泛,在技术装备、技术方法和管理方法上具有传统气象所不具备的特点.针对气象电子设备的管理与维修方法进行论述,并对相应的通讯网络设计进行分析,该方法对了解和掌握设备检修和网络保障具有重要作用.%Computer and infermation technology had already developed and applied widely in our meteorology. It has some special features compared with traditional metorology as technology equipment, method and management way. The paper mainly discuss the management ancl repeir method of meterology electronic equipment, and analyze network design, it has great effect on equipment repair and network ensurence.

  4. Proceedings of the sixth international conference on material issues in design, manufacturing and operation of nuclear power plants equipment. Volume 2

    International Nuclear Information System (INIS)

    The papers reported at the 6-Th International conference Materials issues in design, manufacturing and operation of nuclear power plants equipment are presented. The emphasis is on the problem of structural integrity with taking account for reactor vessel irradiation. The problems of extension of service life for reactors of the first generation are under discussion. The most of papers deal with stainless, low alloy and carbon steel testing for fracture toughness, fatigue strength, resistance to stress-corrosion cracking in both base metal and welded joints

  5. Impact of design of installations and in the personal staff formation of the hybrid equipment: PET-CT

    International Nuclear Information System (INIS)

    In this article the general principles to be considered in the design of a Nuclear Medicine department with PET-CT, and address the existing problems regarding training needs and staff training, to take on this new technology

  6. Antifouling self-assembled monolayers on microelectrodes for patterning biomolecules.

    Science.gov (United States)

    Noel, John; Teizer, Winfried; Hwang, Wonmuk

    2009-01-01

    We present a procedure for forming a poly(ethylene glycol) (PEG) trimethoxysilane self-assembled monolayer (SAM) on a silicon substrate with gold microelectrodes. The PEG-SAM is formed in a single assembly step and prevents biofouling on silicon and gold surfaces. The SAM is used to coat microelectrodes patterned with standard, positive-tone lithography. Using the microtubule as an example, we apply a DC voltage to induce electrophoretic migration to the SAM-coated electrode in a reversible manner. A flow chamber is used for imaging the electrophoretic migration and microtubule patterning in situ using epifluorescence microscopy. This method is generally applicable to biomolecule patterning, as it employs electrophoresis to immobilize target molecules and thus does not require specific molecular interactions. Further, it avoids problems encountered when attempting to pattern the SAM molecules directly using lithographic techniques. The compatibility with electron beam lithography allows this method to be used to pattern biomolecules at the nanoscale. PMID:19707178

  7. Models for Energy and Charge Transport, and Storage in Biomolecules

    CERN Document Server

    Mingaleev, S F; Gaididei, Yu B; Johansson, M; Rasmussen, K O; Mingaleev, Serge F.; Christiansen, Peter L.; Gaididei, Yuri B.; Johansson, Magnus; Rasmussen, Kim O.

    1999-01-01

    Two models for energy and charge transport and storage in biomolecules are considered. A model based on the discrete nonlinear Schrodinger equation with long-range dispersive interactions (LRI's) between base pairs of DNA is offered for the description of nonlinear dynamics of the DNA molecule. We show that LRI's are responsible for the existence of an interval of bistability where two stable stationary states, a narrow, pinned state and a broad, mobile state, coexist at each value of the total energy. The possibility of controlled switching between pinned and mobile states is demonstrated. The mechanism could be important for controlling energy storage and transport in DNA molecules. Another model is offered for the description of nonlinear excitations in proteins and other anharmonic biomolecules. We show that in the highly anharmonic systems a bound state of Davydov and Boussinesq solitons can exist.

  8. Designing of fast reactor equipment and pipelines: Normative method for calculation of long-term cyclic strength

    International Nuclear Information System (INIS)

    The paper deals with the method for calculational analysis of long-term cyclic strength recommended by ''Norms for strength...'' to estimate cyclic damage of equipment items being operated at temperatures which cause creep and loaded by repeated thermal or mechanical forces. The paper gives formulae interrelating amplitude of allowable conditional elastic stresses [σAF] and allowable number [N0] of cycles, as well as calculational fatigue curves for alloyed steels, corrosion-resistant austenitic steels at loading duration of 1·105 hours. The paper describes the method for calculational analysis of long-term cyclic strength for items made from steels with non-metallic inclusions, for items contacting with corrosion-aggressive media, welded joints etc. An example of calculational analysis of long-term cyclic strength by the use of recommended normative method is given. It is shown that the item analyzed as an example (the joint of upper tube sheet of BN-600 intermediate heat exchanger and outer shell) has cyclic strength meeting the requirements of ''Norms for strength...'' valid in Russia. (author). 2 refs, 6 figs, 14 tabs

  9. Immobilization of different biomolecules by atomic force microscopy

    Directory of Open Access Journals (Sweden)

    Hölzel Ralph

    2010-05-01

    Full Text Available Abstract Background Micrometer resolution placement and immobilization of probe molecules is an important step in the preparation of biochips and a wide range of lab-on-chip systems. Most known methods for such a deposition of several different substances are costly and only suitable for a limited number of probes. In this article we present a flexible procedure for simultaneous spatially controlled immobilization of functional biomolecules by molecular ink lithography. Results For the bottom-up fabrication of surface bound nanostructures a universal method is presented that allows the immobilization of different types of biomolecules with micrometer resolution. A supporting surface is biotinylated and streptavidin molecules are deposited with an AFM (atomic force microscope tip at distinct positions. Subsequent incubation with a biotinylated molecule species leads to binding only at these positions. After washing streptavidin is deposited a second time with the same AFM tip and then a second biotinylated molecule species is coupled by incubation. This procedure can be repeated several times. Here we show how to immobilize different types of biomolecules in an arbitrary arrangement whereas most common methods can deposit only one type of molecules. The presented method works on transparent as well as on opaque substrates. The spatial resolution is better than 400 nm and is limited only by the AFM's positional accuracy after repeated z-cycles since all steps are performed in situ without moving the supporting surface. The principle is demonstrated by hybridization to different immobilized DNA oligomers and was validated by fluorescence microscopy. Conclusions The immobilization of different types of biomolecules in high-density microarrays is a challenging task for biotechnology. The method presented here not only allows for the deposition of DNA at submicrometer resolution but also for proteins and other molecules of biological relevance that

  10. Optical Sensors for Biomolecules Using Nanoporous Sol-Gel Materials

    Science.gov (United States)

    Fang, Jonathan; Zhou, Jing C.; Lan, Esther H.; Dunn, Bruce; Gillman, Patricia L.; Smith, Scott M.

    2004-01-01

    An important consideration for space missions to Mars is the ability to detect biosignatures. Solid-state sensing elements for optical detection of biological entities are possible using sol-gel based biologically active materials. We have used these materials as optical sensing elements in a variety of bioassays, including immunoassays and enzyme assays. By immobilizing an appropriate biomolecule in the sol-gel sensing element, we have successfully detected analytes such as amino acids and hormones. In the case of the amino acid glutamate, the enzyme glutamate dehydrogenase was the immobilized molecule, whereas in the case of the hormone cortisol, an anti-cortisol antibody was immobilized in the sensing element. In this previous work with immobilized enzymes and antibodies, excellent sensitivity and specificity were demonstrated in a variety of formats including bulk materials, thin films and fibers. We believe that the sol-gel approach is an attractive platform for bioastronautics sensing applications because of the ability to detect a wide range of entities such as amino acids, fatty acids, hopanes, porphyrins, etc. The sol-gel approach produces an optically transparent 3D silica matrix that forms around the biomolecule of interest, thus stabilizing its structure and functionality while allowing for optical detection. This encapsulation process protects the biomolecule and leads to a more "rugged" sensor. The nanoporous structure of the sol-gel matrix allows diffusion of small target molecules but keeps larger, biomolecules immobilized in the pores. We are currently developing these biologically active sol-gel materials into small portable devices for on-orbit cortisol detection

  11. Mapping the Chemical Universe of Biomolecules for Astrobiology

    OpenAIRE

    Meringer, Markus

    2015-01-01

    Understanding the origins of life is a central question of Astrobiology. Computer methods offer unique means to approach this challenge. In order to obtain a better understanding of the selection rules which guided chemical and early biochemical evolution, our approach is to computationally generate exhaustive sets of biomolecule analogues, to calculate their physico-chemical properties, and to simulate adaptive processes that might have led to the biochemical foundations of life as we know i...

  12. The first search for glycine and other biomolecules

    OpenAIRE

    Storey, J. W. V.

    2012-01-01

    In the 1970s the microwave spectroscopy group at Monash University became the first in the world to determine the spectral frequencies of urea, glycine, and several other biomolecules. We immediately searched for these at Parkes, using existing centimetre-wave receivers plus newly built receivers that operated at frequencies as high as 75GHz (and used just the central 17 m of the dish). Although these searches were largely unsuccessful, they helped launch the now flourishing field of astrobio...

  13. Models and algorithms for biomolecules and molecular networks

    CERN Document Server

    DasGupta, Bhaskar

    2016-01-01

    By providing expositions to modeling principles, theories, computational solutions, and open problems, this reference presents a full scope on relevant biological phenomena, modeling frameworks, technical challenges, and algorithms. * Up-to-date developments of structures of biomolecules, systems biology, advanced models, and algorithms * Sampling techniques for estimating evolutionary rates and generating molecular structures * Accurate computation of probability landscape of stochastic networks, solving discrete chemical master equations * End-of-chapter exercises

  14. Thermo-responsive hydrogels for intravitreal injection and biomolecule release

    Science.gov (United States)

    Drapala, Pawel

    In this dissertation, we develop an injectable polymer system to enable localized and prolonged release of therapeutic biomolecules for improved treatment of Age-Related Macular Degeneration (AMD). Thermo-responsive hydrogels derived from N-isopropylacrylamide (NIPAAm) and cross-linked with poly(ethylene glycol) (PEG) poly(L-Lactic acid) (PLLA) copolymer were synthesized via free-radical polymerization. These materials were investigated for (a) phase change behavior, (b) in-vitro degradation, (c) capacity for controlled drug delivery, and (d) biocompatibility. The volume-phase transition temperature (VPTT) of the PNIPAAm- co-PEG-b-PLLA hydrogels was adjusted using hydrophilic and hydrophobic moieties so that it is ca. 33°C. These hydrogels did not initially show evidence of degradation at 37°C due to physical cross-links of collapsed PNIPAAm. Only after addition of glutathione chain transfer agents (CTA)s to the precursor did the collapsed hydrogels become fully soluble at 37°C. CTAs significantly affected the release kinetics of biomolecules; addition of 1.0 mg/mL glutathione to 3 mM cross-linker accelerated hydrogel degradation, resulting in 100% release in less than 2 days. This work also explored the effect of PEGylation in order to tether biomolecules to the polymer matrix. It was demonstrated that non-site-specific PEGylation can postpone the burst release of solutes (up to 10 days in hydrogels with 0.5 mg/mL glutathione). Cell viability assays showed that at least two 20-minute buffer extraction steps were needed to remove cytotoxic elements from the hydrogels. Clinically-used therapeutic biomolecules LucentisRTM and AvastinRTM were demonstrated to be both stable and bioactive after release form PNIPAAm-co-PEG-b-PLLA hydrogels. The thermo-responsive hydrogels presented here offer a promising platform for the localized delivery of proteins such as recombinant antibodies.

  15. Spatially Controlled Covalent Immobilization of Biomolecules on Silicon Surfaces

    OpenAIRE

    Pavlovic, Elisabeth

    2003-01-01

    The work described in this thesis aims to achieving surface patterning through chemical activation of thiolated silicon oxide surfaces, resulting in a spatially controlled covalent immobilization of biomolecules with high resolution. Existing chemical methods to immobilize molecules on surfaces do not reach below the micrometer scale while the ones allowing for spatial control mostly lead to non-covalent adsorption of molecules on surfaces, or require several successive chemical reactions to ...

  16. Development of radioactively labelled cancer seeking biomolecules for targeted radiotherapy

    International Nuclear Information System (INIS)

    The main objective of this project is the labelling and quality control of biomolecules with radionuclides beta emitters with high purity and stability. Techniques and methodology for labelling with 188Re, 153Sm, and 125I as well as quality controls were done according the recommendations of the first research coordination meeting of this CRP. Also some useful chelators reported in the literature were synthesized in our laboratory

  17. The first search for glycine and other biomolecules

    CERN Document Server

    Storey, J W V

    2012-01-01

    In the 1970s the microwave spectroscopy group at Monash University became the first in the world to determine the spectral frequencies of urea, glycine, and several other biomolecules. We immediately searched for these at Parkes, using existing centimetre-wave receivers plus newly built receivers that operated at frequencies as high as 75GHz (and used just the central 17 m of the dish). Although these searches were largely unsuccessful, they helped launch the now flourishing field of astrobiology.

  18. Capillary Electrophoresis-based Methodology Development for Biomolecule Analysis

    OpenAIRE

    Li, Ni

    2011-01-01

    Capillary electrophoresis (CE) is a separation tool with wide applications in biomolecule analysis. Fast and high-resolution separation requiring minute sample volumes is advantageous to study multiple components in biological samples. Flexible modes and methods can be developed. In this thesis, I focus on developing and applying novel CE methods to study multi-target nucleic acid sensing with high sensitivity (Part I) and interactions between multiple components, i.e. proteins, nanoparticles...

  19. Renewable-Biomolecule-Based Full Lithium-Ion Batteries.

    Science.gov (United States)

    Hu, Pengfei; Wang, Hua; Yang, Yun; Yang, Jie; Lin, Jie; Guo, Lin

    2016-05-01

    A renewable-biomolecule-based full lithium-ion battery is successfully fabricated for the first time. Naturally derivable emodin and humic acid based electrodes are used as cathode and anode, respectively. The as-assembled batteries exhibit superb specific capacity and substantial operating voltage capable of powering a wearable electronic watch, suggesting the great potential for practical applications with the significant merits of sustainability and biocompatibility. PMID:26989989

  20. Solvent Influence on Photochemistry of Small Biomolecules in Clusters

    Czech Academy of Sciences Publication Activity Database

    Profant, V.; Dian, J.; Fárník, Michal; Poterya, Viktoriya

    Prague : MATFYZPRESS, 2008 - (Šafránková, J.; Pavlů, J.), s. 136-141 ISBN 978-80-7378-067-8. [Annual Conference of Doctoral Student /17./, WDS´08. Prague (CZ), 03.06.2008-06.06.2008] R&D Projects: GA ČR GA203/06/1290; GA AV ČR KAN400400651 Institutional research plan: CEZ:AV0Z40400503 Keywords : biomolecules * clusters * photochemistry Subject RIV: CF - Physical ; Theoretical Chemistry

  1. Models for Energy and Charge Transport and Storage in Biomolecules

    OpenAIRE

    Mingaleev, S. F.; Christiansen, P. L.; Gaididei, Yu. B.; M. Johansson; Rasmussen, K.Ø.

    1999-01-01

    Two models for energy and charge transport and storage in biomolecules are considered. A model based on the discrete nonlinear Schrodinger equation with long-range dispersive interactions (LRI's) between base pairs of DNA is offered for the description of nonlinear dynamics of the DNA molecule. We show that LRI's are responsible for the existence of an interval of bistability where two stable stationary states, a narrow, pinned state and a broad, mobile state, coexist at each value of the tot...

  2. Structure, dynamics, and function of biomolecules

    Energy Technology Data Exchange (ETDEWEB)

    Frauenfelder, H.; Berendzen, J.R.; Garcia, A.; Gupta, G.; Olah, G.A.; Terwilliger, T.C.; Trewhella, J.; Wood, C.C.; Woodruff, W.H.

    1998-11-01

    This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The authors enhanced Los Alamos' core competency in Bioscience and Biotechnology by building on present strengths in experimental techniques, theory, high-performance computing, modeling, and simulation applied to biomolecular structure, dynamics, and function. Specifically, the authors strengthened their capabilities in neutron/x-ray scattering, x-ray crystallography, NMR, laser, and optical spectroscopies. Initially they focused on supporting the Los alamos Neutron Science Center (LANSCE) in the design and implementation of new neutron scattering instrumentation, they developed new methods for analysis of scattering data, and they developed new projects to study the structures of biomolecular complexes. The authors have also worked to strengthen interactions between theory and experiment, and between the biological and physical sciences. They sponsored regular meetings of members from all interested LANL technical divisions, and supported two lecture series: ''Biology for Physicists'' and ''Issues in Modern Biology''. They also supported the formation of interdisciplinary/inter-divisional teams to develop projects in science-based bioremediation and an integrated structural biology resource. Finally, they successfully worked with a multidisciplinary team to put forward the Laboratory's Genome and Beyond tactical goal.

  3. Structure, dynamics, and function of biomolecules

    International Nuclear Information System (INIS)

    This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The authors enhanced Los Alamos' core competency in Bioscience and Biotechnology by building on present strengths in experimental techniques, theory, high-performance computing, modeling, and simulation applied to biomolecular structure, dynamics, and function. Specifically, the authors strengthened their capabilities in neutron/x-ray scattering, x-ray crystallography, NMR, laser, and optical spectroscopies. Initially they focused on supporting the Los alamos Neutron Science Center (LANSCE) in the design and implementation of new neutron scattering instrumentation, they developed new methods for analysis of scattering data, and they developed new projects to study the structures of biomolecular complexes. The authors have also worked to strengthen interactions between theory and experiment, and between the biological and physical sciences. They sponsored regular meetings of members from all interested LANL technical divisions, and supported two lecture series: ''Biology for Physicists'' and ''Issues in Modern Biology''. They also supported the formation of interdisciplinary/inter-divisional teams to develop projects in science-based bioremediation and an integrated structural biology resource. Finally, they successfully worked with a multidisciplinary team to put forward the Laboratory's Genome and Beyond tactical goal

  4. Research on lightweight design of airborne electronic equipments%机载电子装备轻量化设计初步研究

    Institute of Scientific and Technical Information of China (English)

    李雨; 魏强

    2014-01-01

    机载电子装备日益复杂化,飞机平台资源的有限性迫切要求其开展有效的轻量化工作。从系统顶层设计、总体布局、硬件设计、新型材料等方面论述了如何在机载电子装备研制过程中开展轻量化工作,对当前实际工程开展轻量化工作具有一定的指导意义。%With the increasing complication of airborne electronic equipments,the lightweight research is exigent due to the limitation of airborne space resource. The lightweight research in the process of airborne electronic equipment development is discussed in the aspects of system top-design,overall-layout,hardware design and new materials,which has a certain guiding significance for lightweight of the current engineering projects.

  5. Design of Electrical Training Equipment Control System Based on PLC%PLC电工实训装置控制系统设计

    Institute of Scientific and Technical Information of China (English)

    周飞; 张英琦

    2013-01-01

    以矿井提升绞车为模型,设计了一个基于PLC的电工实训装置,从功能上讲,主要由提升绞车模型、PLC电气控制系统、变频器变频调速系统、触摸屏监控系统组成。给出了系统方案,设计了PLC控制系统、信号检测电路和变频器控制电路。该实训装置突出“工矿”特色,既包括各种电气控制技术的基础实践训练,又包括多种电工技术的综合性实践训练。%Taking the mine hoist as model, electrical training equipment based on PLC is designed in the paper. From the func-tional point of view, the equipment is mainly composed of mine hoist model, PLC control system, inverter frequency control sys-tem and touch screen monitoring systems. The system scheme is proposed. The PLC control system, signal detection circuit and the inverter control system is designed. The training device outstanding industrial and mineral characteristic, including both vari-ous electric control technology foundation practice training, and variety of electrical technologies comprehensive practical train-ing.

  6. Applications of polymers for biomolecule immobilization in electrochemical biosensors

    International Nuclear Information System (INIS)

    Polymers are becoming inseparable from biomolecule immobilization strategies and biosensor platforms. Their original role as electrical insulators has been progressively substituted by their electrical conductive abilities, which opens a new and broad scope of applications. In addition, recent advances in diagnostic chips and microfluidic systems, together with the requirements of mass-production technologies, have raised the need to replace glass by polymeric materials, which are more suitable for production through simple manufacturing processes. Conducting polymers (CPs), in particular, are especially amenable for electrochemical biosensor development for providing biomolecule immobilization and for rapid electron transfer. It is expected that the combination of known polymer substrates, but also new transducing and biocompatible interfaces, with nanobiotechnological structures, like nanoparticles, carbon nanotubes (CNTs) and nanoengineered 'smart' polymers, may generate composites with new and interesting properties, providing higher sensitivity and stability of the immobilized molecules, thus constituting the basis for new and improved analytical devices for biomedical and other applications. This review covers the state-of-the-art and main novelties about the use of polymers for immobilization of biomolecules in electrochemical biosensor platforms

  7. Repulsive effects of hydrophobic diamond thin films on biomolecule detection

    Energy Technology Data Exchange (ETDEWEB)

    Ruslinda, A. Rahim, E-mail: ruslindarahim@gmail.com [Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, Jln Kgr-Alor Setar, Seriab, 01000 Kangar, Perlis (Malaysia); Department of Nano Science and Nano Engineering, School of Advance Science and Engineering, Ohkubo 3-4-1, Shinjuku, 169-8555 Tokyo (Japan); Ishiyama, Y. [Department of Nano Science and Nano Engineering, School of Advance Science and Engineering, Ohkubo 3-4-1, Shinjuku, 169-8555 Tokyo (Japan); Penmatsa, V. [Department of Mechanical and Materials Engineering, Florida International University, 10555 West Flagler Street, Miami, FL 33174 (United States); Ibori, S.; Kawarada, H. [Department of Nano Science and Nano Engineering, School of Advance Science and Engineering, Ohkubo 3-4-1, Shinjuku, 169-8555 Tokyo (Japan)

    2015-02-15

    Highlights: • We report the effect of fluorine plasma treatment on diamond thin film to resist the nonspecific adsorption of biomolecules. • The diamond thin film were highly hydrophobic with a surface energy value of ∼25 mN/m. • The repulsive effect shows excellent binding efficiency for both DNA and HIV-1 Tat protein. - Abstract: The repulsive effect of hydrophobic diamond thin film on biomolecule detection, such as single-nucleotide polymorphisms and human immunodeficiency virus type 1 trans-activator of transcription peptide protein detection, was investigated using a mixture of a fluorine-, amine-, and hydrogen-terminated diamond surfaces. These chemical modifications lead to the formation of a surface that effectively resists the nonspecific adsorption of proteins and other biomolecules. The effect of fluorine plasma treatment on elemental composition was also investigated via X-ray photoelectron spectroscopy (XPS). XPS results revealed a fluorocarbon layer on the diamond thin films. The contact angle measurement results indicated that the fluorine-treated diamond thin films were highly hydrophobic with a surface energy value of ∼25 mN/m.

  8. Repulsive effects of hydrophobic diamond thin films on biomolecule detection

    International Nuclear Information System (INIS)

    Highlights: • We report the effect of fluorine plasma treatment on diamond thin film to resist the nonspecific adsorption of biomolecules. • The diamond thin film were highly hydrophobic with a surface energy value of ∼25 mN/m. • The repulsive effect shows excellent binding efficiency for both DNA and HIV-1 Tat protein. - Abstract: The repulsive effect of hydrophobic diamond thin film on biomolecule detection, such as single-nucleotide polymorphisms and human immunodeficiency virus type 1 trans-activator of transcription peptide protein detection, was investigated using a mixture of a fluorine-, amine-, and hydrogen-terminated diamond surfaces. These chemical modifications lead to the formation of a surface that effectively resists the nonspecific adsorption of proteins and other biomolecules. The effect of fluorine plasma treatment on elemental composition was also investigated via X-ray photoelectron spectroscopy (XPS). XPS results revealed a fluorocarbon layer on the diamond thin films. The contact angle measurement results indicated that the fluorine-treated diamond thin films were highly hydrophobic with a surface energy value of ∼25 mN/m

  9. 低功耗水下通信系统设计%Design of Low Power Underwater Equipment Communication System

    Institute of Scientific and Technical Information of China (English)

    杨勃锋; 张效民; 祖翔宇

    2012-01-01

    The low power underwater equipment communication system is based on MSP430 MCU and the series of TMS32OC55x DSP. The MCU is in power state and monitors the communication control signal persistently in the system. The DSP is closed in no communicatioi time. Until the MCU receives communication instructions, the DSP is turned on after opening the power of DSP, then receives and decode the signal. After the DSP accomplishes communication and operates instructions, the DSP is turned off. The MCU detects the communicatioi control signal using sliding related method, and controls the power of DSP to start -up DSP. The experiments show that the system can ef fectively reduce the power, when the communication time ls 1% of the total time,The system can save 88.7% of the power.%设计了一种基于MSP430单片机和TMS320C55x系列DSP的低功耗水下通信系统,该系统中单片机一直处于上电状态,实时监测通信控制信号,在非通信时段DSP处于关机状态,单片机收到通信指令后,通过启动DSP电源启动DSP接收并解码通信信号,DSP完成通信并进行相关的指令操作后关机;单片机通过滑动相关方法检测通信控制信号,通过控制DSP电源启动关闭DSP,实验表明该系统能有效的降低功率,其中在通信时段占总时段1%的情况下,该系统能节省88.7%的功率.

  10. Simulation Using Novel Equipment Designed to Explain Spirometric Abnormalities in Respiratory Disease Enhances Learning in Higher Cognitive Domains

    Science.gov (United States)

    Jamison, J. P.; Stewart, M. T.

    2015-01-01

    Simulation of disorders of respiratory mechanics shown by spirometry provides insight into the pathophysiology of disease but some clinically important disorders have not been simulated and none have been formally evaluated for education. We have designed simple mechanical devices which, along with existing simulators, enable all the main…

  11. Development of a combined surface plasmon resonance/surface acoustic wave device for the characterization of biomolecules

    International Nuclear Information System (INIS)

    It is known that acoustic sensor devices, if operated in liquid phase, are sensitive not just to the mass of the analyte but also to various other parameters, such as size, shape, charge and elastic constants of the analyte as well as bound and viscously entrained water. This can be used to extract valuable information about a biomolecule, particularly if the acoustic device is combined with another sensor element which is sensitive to the mass or amount of analyte only. The latter is true in good approximation for various optical sensor techniques. This work reports on the development of a combined surface plasmon resonance/surface acoustic wave sensor system which is designed for the investigation of biomolecules such as proteins or DNA. Results for the deposition of neutravidin and DNA are reported

  12. Design and testing of Ground Penetrating Radar equipment dedicated for civil engineering applications: ongoing activities in Working Group 1 of COST Action TU1208

    Science.gov (United States)

    Pajewski, Lara; Manacorda, Guido; Persico, Raffaele

    2015-04-01

    This work aims at presenting the ongoing research activities carried out in Working Group 1 'Novel GPR instrumentation' of the COST (European COoperation in Science and Technology) Action TU1208 'Civil Engineering Applications of Ground Penetrating Radar' (www.GPRadar.eu). The principal goal of the COST Action TU1208 is to exchange and increase scientific-technical knowledge and experience of GPR techniques in civil engineering, simultaneously promoting throughout Europe the effective use of this safe and non-destructive technique in the monitoring of infrastructures and structures. Working Group 1 (WG1) of the Action focuses on the development of innovative GPR equipment dedicated for civil engineering applications. It includes three Projects. Project 1.1 is focused on the 'Design, realisation and optimisation of innovative GPR equipment for the monitoring of critical transport infrastructures and buildings, and for the sensing of underground utilities and voids.' Project 1.2 is concerned with the 'Development and definition of advanced testing, calibration and stability procedures and protocols, for GPR equipment.' Project 1.3 deals with the 'Design, modelling and optimisation of GPR antennas.' During the first year of the Action, WG1 Members coordinated between themselves to address the state of the art and open problems in the scientific fields identified by the above-mentioned Projects [1, 2]. In carrying our this work, the WG1 strongly benefited from the participation of IDS Ingegneria dei Sistemi, one of the biggest GPR manufacturers, as well as from the contribution of external experts as David J. Daniels and Erica Utsi, sharing with the Action Members their wide experience on GPR technology and methodology (First General Meeting, July 2013). The synergy with WG2 and WG4 of the Action was useful for a deep understanding of the problems, merits and limits of available GPR equipment, as well as to discuss how to quantify the reliability of GPR results. An

  13. Disposable pen-shaped capillary gel electrophoresis cartridge for fluorescence detection of bio-molecules

    Science.gov (United States)

    Amirkhanian, Varoujan; Tsai, Shou-Kuan

    2014-03-01

    We introduce a novel and cost-effective capillary gel electrophoresis (CGE) system utilizing disposable pen-shaped gelcartridges for highly efficient, high speed, high throughput fluorescence detection of bio-molecules. The CGE system has been integrated with dual excitation and emission optical-fibers with micro-ball end design for fluorescence detection of bio-molecules separated and detected in a disposable pen-shaped capillary gel electrophoresis cartridge. The high-performance capillary gel electrophoresis (CGE) analyzer has been optimized for glycoprotein analysis type applications. Using commercially available labeling agent such as ANTS (8-aminonapthalene-1,3,6- trisulfonate) as an indicator, the capillary gel electrophoresis-based glycan analyzer provides high detection sensitivity and high resolving power in 2-5 minutes of separations. The system can hold total of 96 samples, which can be automatically analyzed within 4-5 hours. This affordable fiber optic based fluorescence detection system provides fast run times (4 minutes vs. 20 minutes with other CE systems), provides improved peak resolution, good linear dynamic range and reproducible migration times, that can be used in laboratories for high speed glycan (N-glycan) profiling applications. The CGE-based glycan analyzer will significantly increase the pace at which glycoprotein research is performed in the labs, saving hours of preparation time and assuring accurate, consistent and economical results.

  14. The design of vertical installation equipment for the piston rod production line%活塞杆竖直装挂进料装置的设计

    Institute of Scientific and Technical Information of China (English)

    杨振; 张艳冬; 刘占娟

    2015-01-01

    目前国内活塞杆电镀时的竖直装挂主要靠人工完成,劳动强度大,且效率低。针对某公司现有的活塞杆电镀挂具,进行了竖直装挂进料装置的设计,主要包括机械部分和控制系统。装置采用伺服电机和气压作为驱动,螺旋传动实现工作台移位,接近开关和控制伺服电机转动圈数定位方式相结合,实现多根活塞杆同时自动进给,降低了劳动强度,提高了工作效率。%At the present stage the main feed way to vertical installation of the piston rod is artificial and comple-ted.It not only needs high labor intensity, but also is low efficiency.Aiming at the electroplating production line with piston rod in a company, it introduces the design of vertical installation equipment such as mechanical and control system.The equipment uses the servo motor and air pressure as drive, moves the table by rotating the transmission shift.The position switch and servo motor realizes automatic feeding of several piston rods.This e-quipment can reduce the labor intensity and improve the work efficiency.

  15. Engineering Design of A Gang Drilling Machine Equipped with Jig and Fixtures to Make A Prototype Machine in Birdcage Production

    Directory of Open Access Journals (Sweden)

    Eddy Widiyono

    2011-11-01

    Full Text Available This paper is dealing with the engineering design of a gang drilling machine with jig & fixtures to make a prototype machine. This effort has been done in order to solve the problem which aroused in small business enterprises producing birdcages. The problem was how to minimize the production time in making a lot of holes that have same distance and straightness. Hopefully, the prototype machine can help the small business enterprises to increase their production rate.The design engineering process has been carried out by variant approximation on dowel pin modular fixtures in order to simplify fixtures design. CAD CAM software has also been used as fixtures synthesized method including geometric analysis and three dimensional fixtures assembling. The resulting prototype machine can be well operated and based on the running test, it can be concluded that the greater the motor rotation the greater the power needed. As for teak wood, at 250 rpm motor rotation the power needed is 26.5 watt, and at 400 rpm the motor needs power of 43.6 watt while at 600 rpm the motor needs power of 600 watt. The power consumption is also depends on the type of material, the better the mechanical properties of the materials, the higher the power consumption. For cast iron, the 400 rpm motor rotation needs power as high as 569.7 watt. This prototype of gang drilling machine needs power of 350 watt to make five holes on teak wood while ordinary drilling machine needs total power of 1350 watt.

  16. Design, construction and testing of replacement nuclear coolant pump stators to meet today's equipment reliability expectations

    Energy Technology Data Exchange (ETDEWEB)

    Fostier, L. [AREVA-Jeumont S.A. (France); Howell, D. [Duke Energy Corp., Charlotte, NC (United States)

    2005-07-01

    The continuous and reliable operation of nuclear power plants is critical to a utility's commercial bottom line. Many electric utilities with nuclear and other generating assets use non-nuclear generation to meet peak load and off-system power sales. Although motors installed during original construction have given fairly reliable service, the expectations in today's power generation market require that any improvements that could increase reliability should be used. This paper addressed the importance of reliability in a reactor coolant pump winding in a pressurized water reactor plant. The maintenance approach taken by one North American utility to avoid failure was presented. The challenges of the reactor coolant pump application was also discussed along with the improvements made in the winding design and construction. It was noted that the design margins incorporated into a reactor coolant pump motor will probably exceed those used for similar sized induction motors used for other industries due to the economic, radiological and nuclear safety concerns associated with an in service failure. As such, reactor coolant pump motors must meet special requirements based on the manufacturer experience, standards, electrotechnical standards and the customers request. The design of stators has resulted in improvements to address the following stress mechanisms: reduce thermal deterioration rate; inadequate resin bonding; loose windings; end winding corona; partial discharge; turn insulation stress or defects; and surface moisture and contamination. Validation testing was conducted on the replacement stator, including type tests on the initial stator and coils, in-process testing and final acceptance testing. All test results met the specified acceptance criteria. 7 refs., 2 tabs., 12 figs.

  17. 智能变电站二次设备模块化设计技术%Modular Design of Secondary Equipment in Smart Substation

    Institute of Scientific and Technical Information of China (English)

    李宾皑; 翁之浩

    2016-01-01

    贯彻安全可靠、经济合理、技术先进、环境友好的技术原则,完成国家电网公司企业标准《模块化二次设备设计技术导则》的制定工作。结合模块化二次设备设计技术的相应研究成果,从模块定义与划分原则、模块技术要求、功能单元技术要求和模块布置要求4个方面解读主要条款的编制思路、基本原理以及注意事项。该标准能够大幅提高电气设备集成化水平,实现工厂工作量最大化、现场工作量最小化,可以大幅提高工程建设水平;所提出的模块化二次设备可促进国内厂家生产技术水平的提高,有效地节约社会资源,降低工程建设成本;对模块化二次设备设计作规定,填补国内空白,为智能变电站电气二次模块化设计提供重要依据。%To implement the engineering philosophy of security, reliability, reasonable economy, advanced technology and friendly environment, company standard of State Grid, “Technical specification for modularized secondary equipment” has been finished. Based on the corresponding research results of the modular secondary equipment design technology, the compiling thinking, basic principle and the matters needing attention of the main terms are explained from the four aspects of module definition and classification principles, module technical requirements, functional unit technical requirements and module layout. This standard can greatly improve the integration level of electrical equipment, and maximize factory work, minimize onsite workload, and can greatly improve the level of project construction as well. The modular secondary equipment proposed by this standard can greatly promote the level of production technology of domestic manufacturers, effectively save social resources, and reduce the cost of project construction. This standard can make rules for the design of modular secondary equipment, which fills in the home gaps, and

  18. Design of Wireless Control Device on Engineering Equipment%工程装备无线控制装置设计

    Institute of Scientific and Technical Information of China (English)

    李鹏; 赵建民

    2016-01-01

    In this paper, wireless control for the amphibious armored pavement operation could be realized by using the wire-less communication technology and the single-chip microcomputer control technology without changing the original circuit and structures of equipment.Through design of the wireless control system, it provides more control ways for the engineering e-quipments, improves the operation flexibility and operation efficiency, and offers worker with security assurance.%运用无线通信技术和单片机控制技术实现两栖装甲路面作业的无线控制,且不改变装备原有的电路和结构。通过设计无线控制系统,为工程装备提供更多的控制方式,提高了装备的作业灵活性和作业效率,同时也为作业手作业提供了安全保障。

  19. 一种康复设备医疗网络平台的设计%Design of the Medical Rehabilitation Equipment Network Platform

    Institute of Scientific and Technical Information of China (English)

    朱沪生; 喻洪流; 吴刘海

    2015-01-01

    This paper mainly introduces the design of the medical rehabilitation equipment network plat-form. Our goal is to realize digital management of hospital rehabilitation department,to integrate and control a vari-ety of rehabilitation equipments in the same platform and save the rehabilitation training data and finally to help doctors and patients communicate with multi platforms. The platform is constructed by using Struts2 + Spring + Hi-bernate(SSH)framework,and is implemented by using Java language,JSP technology,HTML language,JQuery plugin script technology and MySQL5 database technology.%该文主要介绍了一种康复设备医疗网络平台的设计,目标是实现医院康复科的数字化管理,集成多种康复设备于同一平台进行控制和保存训练数据,帮助医患双方实现多平台沟通。平台采用 Struts2+ Spring + Hibernate(SSH)架构,结合 Java 语言、JSP 技术、HTML 语言、JQuery 插件脚本技术和 MySQL5数据库技术对平台进行实现。

  20. Fused deposition of ceramics: A comprehensive experimental, analytical and computational study of material behavior, fabrication process and equipment design

    Science.gov (United States)

    Bellini, Anna

    Customer-driven product customization and continued demand for cost and time savings have generated a renewed interest in agile manufacturing based on improvements on Rapid Prototyping (RP) technologies. The advantages of RP technologies are: (1) ability to shorten the product design and development time, (2) suitability for automation and decrease in the level of human intervention, (3) ability to build many geometrically complex shapes. A shift from "prototyping" to "manufacturing" necessitates the following improvements: (1) Flexibility in choice of materials; (2) Part integrity and built-in characteristics to meet performance requirements; (3) Dimensional stability and tolerances; (4) Improved surface finish. A project funded by ONR has been undertaken to develop an agile manufacturing technology for fabrication of ceramic and multi-component parts to meet various needs of the Navy, such as transducers, etc. The project is based on adaptation of a layered manufacturing concept since the program required that the new technology be developed based on a commercially available RP technology. Among various RP technologies available today, Fused Deposition Modeling (FDM) has been identified as the focus of this research because of its potential versatility in the choice of materials and deposition configuration. This innovative approach allows for designing and implementing highly complex internal architectures into parts through deposition of different materials in a variety of configurations in such a way that the finished product exhibit characteristics to meet the performance requirements. This implies that, in principle, one can tailor-make the assemble of materials and structures as per specifications of an optimum design. The program objectives can be achieved only through accurate process modeling and modeling of material behavior. Oftentimes, process modeling is based on some type of computational approach where as modeling of material behavior is based on

  1. Conceptual design of a large cavern for giant liquid argon charge imaging equipment in Oki-no-shima Island

    International Nuclear Information System (INIS)

    The T2K utilizing J-PARK high intensity started the data accumulation. If beam intensity of J-PARC will become the 1MW class in the future, we will build the cavern under the ground in Oki-no-shima to accommodate the experiment with 100kton liquid Ar TPC. Geologically, the Oki gneiss in the Oki-no-shima eastern side is very stable. The Oki gneiss is the one of the Japanese oldest rocks born about 2 billion years ago and compressive strength of the bedrock is about 80Mpa over. The development of the crack is not seen and has few springs in the underground. We designed large dome cylindrical cavern(the diameter 90m and the height 50m) for storage 100kton liquid Ar, some access tunnel and others connected to a cavern. (author)

  2. Case study of a traditional material (adobe) for facilities design destined to X-ray equipment emplacement

    International Nuclear Information System (INIS)

    The objective of this work is to use the existent material (adobe) in the national market as an alternative for an optimum design that counts with the conditions for radiological protection as well as an adequate infrastructure to service assistance. Therefore, it gives a tool of professional use for an X-ray installation design, because the adobes represent an adequate protection for employees as Worker occupational exposed (WOE) and for general public, also for economics reasons and construction technical aspects. With the study of above material is demonstrated that in X-ray facilities construction is not always necessary the use of lead sheets or another materials for walls, which are used as shielding elements against ionizing radiation. The adobe election for this study, is because Bolivia counts with a great percentage of constructed areas whit this type of material because is economical and raw material is accessible for users. From the experimental tests we get the graphics that allow to found the half value thickness (HVT) of the half layer (HVL) of this adobe, is that thickness of material with when placed in the path of the radiation will attenuate it to one half its original value. A tenth value thickness (TVT) similarly reduces the radiation to one tenth of its original value. Material which contains heavy atoms and molecules such as steel and lead provide the most effective (thinnest) shields for X-rays. The contribute of this study, carried out with the construction material (adobe) that exists in the national market will be of great utility for society because there is no values recorded in the bibliography. (author)

  3. Conceptual design studies of special-purpose equipment for Fusion Engineering Device torus-sector remote maintenance

    International Nuclear Information System (INIS)

    One of the major maintenance operations anticipated for fusion reactors of the Tokamak configuration is remote removal and replacement of torus sectors. This operation will be difficult due to the massive nature of the sector (375 tonnes), and also due to the precision with which it must be positioned within the fixed structure. The same problem, only to a lesser degree, applies to sub-components of the sector such as the limiter blades, shielding, test assemblies, etc. General and specific design requirements have been generated and trade studies conducted on reactor interfacing details as well as handling machine concepts. On the basis of the design requirements and trade studies, a perferred concept for the sector handling machine was developed. In addition, a similar machine was developed for handling the intermediate sized sector sub-components. While most operations will be performed by special purpose machines such as described above, there is a need for a versatile, relatively high capacity mobile system. A concept suitable for this mobile application was also developed as part of these studies. The general conclusion, to the extent these studies have been completed, was that special single-purpose machines will be required to perform the operations requiring high load capacity and handling precision. The machine concepts developed were felt to be within the state-of-the-art, and will make extensive use of commercially available components. The most serious problem was felt to be development of simple methods to obtain the required precision in positioning massive objects such as the torus sector

  4. Impact in the facilities design and the personnel formation of the hybrid equipment s: PET-CT

    International Nuclear Information System (INIS)

    The Positron Emission Tomography-Computed Tomography (PET-CT), in the last years has demonstrated to be an image technique very effective for the diagnosis and the treatments continuation in different medical applications, because provides a valuable clinical information for the patient handling. The PET-CT is a technology used in the nuclear medicine for diagnostic, because integrates two different image techniques in an only device and in a single exam or study combine the results of both techniques. Also, is a hybrid tomograph that provides in a single image the biochemical information of a technique and the anatomical information of the other, what means that unifies the spatial resolution of a technique and the contrast resolution of the other, allowing this way to obtain a more precise and detailed diagnostic information, opening new opportunities in diagnostic, Radiotherapy planning and treatments continuation to the patients, being generated new links among the different radiological medical specialties. In nuclear medicine facilities with PET-CT, the radiological protection presents particular characteristics, due to the photons coexistence of 511 keV (generated by the annihilation of the emitted positrons from the different exposure sources) together to the X-rays emitted by the CT, what impacts in a direct way in those design requirements of the areas. On the other hand, this combination of the two image techniques imposes additional requirements to the learning and training of personnel, not considered until the present time. In this article are exposed the general principles that should be considered in the design of a Nuclear Medicine Area with PET-CT, and the existent problems related to the learning and training of personnel to assume this new technology are also approached. (Author)

  5. Dynamic Equipment Account Management System Research and Design%设备动态台账管理系统研究和设计

    Institute of Scientific and Technical Information of China (English)

    冀树春; 曹培庆; 郝乾军; 黄伟岗; 韩光美

    2015-01-01

    研究电厂建设期和生产期设备的设计技术参数、安装调试记录、实验数据、运行日志、缺陷故障情况、巡检记录、部件情况、图纸技术资料等技术大数据,并对这些数据进行专业化的提取、统计、分析、共享、加工、关联、整合等,通过集成各个分生产管理信息系统的设备大数据,生成一套设备管理的专业综合数据信息系统,以便快速、有效、准确、系统地掌握各电厂设备运行情况,实现企业设备系统全生命运行状态的动态管理,提高企业生产运营的数字化管理水平及管理的时效性。%The paper studied the technical big-data of the power plant during construction period and production period such as equipment design technical parameters, installation and debugging records, experimental data, run logs, defect fault conditions, inspection records, case parts, drawings and other technical information, and systematic analyzes these data by specialization statistics, analysis, sharing, processing, correlation, integration, integrated device data, etc. By integrating device data for each of the production management information system, the authors generate a comprehensive set of professional equipment management information system which can fast, efficiently, accurately and systematically grasp of the operation situation of the power plant equipment, achieve a dynamic management of the whole life running state enterprise equipment systems, and improve the timeliness of the management level of digital production the operations and management of the power plant.

  6. 卧式连续生物炭炭化设备研制%Design and manufacture of horizontal continuous biomass carbonization equipment

    Institute of Scientific and Technical Information of China (English)

    袁艳文; 田宜水; 赵立欣; 姚宗路

    2014-01-01

    The burning of fossil fuels, the changes in agricultural and land utilization, as well as the industrial processes produce a lot of carbon dioxide and other greenhouse gases causing global warming. Climate increasingly has become one of the most far-reaching global environmental issues. The carbon can be stabilized by biochar for hundreds of years while the carbon element is very difficult to break down after mineralization. With the function of carbon sequestration and soil improvement in agriculture, it turns out to be one of the main ways to reduce carbon emissions in the future. Currently, the producing of biochar has become a hot topic both at home and abroad. In this paper, aiming at the existence of unstable operations, low percentage of biochar outputs, as well as the difficultly of recycling of by-products of China biochar, equipment designs of the horizontal equipment for continuous carbonization of biomass, which uses external thermal heating carbonization of feedstock. The difference requires an external heating fuel, the heat required for the dissertation utilizes the high temperature and gas combustion-generated calorie to carbonize the raw materials., Combustion flue gas during start-up and insufficient supply combined with diesel auxiliary heating of the equipment, the pyrolytic reactor of which is double-layer structure, with the inner layer carbonization chamber equipped with the built-in screw conveyor while the out layer high-temperature flue sleeve, using the motor speed, to ensure the continuous feeding of material, mixing and uniform heat transfer to achieve a biological continuous production of charcoal and carbonization temperature-controlled. The reactor outer sleeve for the high temperature flue gas, the use of high temperature gas to heat biomass, and the outer cylinder has baffles and fins, extending the residence time of the flue gas, and increasing the heat transfer coefficient to achieve a sufficient heat exchange. The paper chooses

  7. 卧式连续生物炭炭化设备研制%Design and manufacture of horizontal continuous biomass carbonization equipment

    Institute of Scientific and Technical Information of China (English)

    袁艳文; 田宜水; 赵立欣; 姚宗路

    2014-01-01

    针对中国生物炭设备中存在的运行不稳定、炭产出率低、副产品回收利用难等问题,该文设计了卧式连续生物炭炭化设备,热解反应器采用双层套筒结构,内层为炭化室,内置螺旋输送机,外层为高温烟气套筒,利用炭化自身产生的高温烟气燃烧产生的热量进行炭化。选择了热解参数,开展了热工设计和可燃气燃烧器热计算,并对炭化室、高温烟气套筒等关键部件进行了结构设计。采用稻壳原料进行了炭化试验,试验结果表明,卧式连续炭化设备实现了连续稳定运行,炭化设备设计合理,原料适用性广,小时生产率为45kg/h,稻壳炭化终温为500℃,炭化得率质量分数为42%。实现了设计目标,提高了炭化得率,为中国生物炭产业的发展提供了理论基础和技术支持。%The burning of fossil fuels, the changes in agricultural and land utilization, as well as the industrial processes produce a lot of carbon dioxide and other greenhouse gases causing global warming. Climate increasingly has become one of the most far-reaching global environmental issues. The carbon can be stabilized by biochar for hundreds of years while the carbon element is very difficult to break down after mineralization. With the function of carbon sequestration and soil improvement in agriculture, it turns out to be one of the main ways to reduce carbon emissions in the future. Currently, the producing of biochar has become a hot topic both at home and abroad. In this paper, aiming at the existence of unstable operations, low percentage of biochar outputs, as well as the difficultly of recycling of by-products of China biochar, equipment designs of the horizontal equipment for continuous carbonization of biomass, which uses external thermal heating carbonization of feedstock. The difference requires an external heating fuel, the heat required for the dissertation utilizes the high temperature

  8. Design and construction of a target chamber and associated equipments for the BARC Charged Particle Detector Array

    International Nuclear Information System (INIS)

    A 60 cm diameter spherical high-vacuum target-chamber with side-opening hemispherical-lids, two ancillary-chambers, beam-line-tubes, tees and other high-vacuum components, and chamber-lid handling systems have been designed, constructed and installed for the Charged Particle Detector Array in BARC-TIFR Pelletron-LINAC Facility, Mumbai. This array of several tens of Si-CsI detector modules and other ancillary-detectors will be used for investigations in fusion-fission dynamics, nuclear structure at elevated temperatures and angular momenta, exotic nuclear clusters and related fields. This paper describes the unique features of the system that aid different coincidence experiments, the chamber fabrication experience and the pump-down characteristics with a turbo molecular pump. Unlike many other target chambers in use, this chamber allows multiple overall geometrical configurations to be set to reach experimental goals. For instance, by replacing a hemispherical-lid from one side with a flat-lid, the overall configuration becomes hemispherical. This way, high geometrical efficiency can be provided to an ancillary gamma detector array by allowing it to move close to target from the flat-lid side, although with some sacrifice of geometrical efficiency for charged particles. In experiments where a further improvement of geometrical efficiency for a gamma array is desired, a third compact-cylinder configuration can also be arrived at. Thinned portion of the lids of the chamber also allow neutron coincidence measurements with charged particles and gamma rays.

  9. Design, Synthesis, and Biological Evaluation of New Cathepsin B-Sensitive Camptothecin Nanoparticles Equipped with a Novel Multifuctional Linker.

    Science.gov (United States)

    Zhang, Xuan; Tang, Kaiyong; Wang, Hong; Liu, Yaqian; Bao, Bin; Fang, Yanfen; Zhang, Xiongwen; Lu, Wei

    2016-05-18

    Traditional antitumor drugs such as camptothecin and paclitaxel derivatives are widely used in cancer chemotherapy. However, the major defects of those agents include severe toxicity and poor water solubility. With these in mind, a novel multifunctional linker was designed and two Cathepsin B (CTB) sensitive CPT conjugates (9a and 9b) were synthesized. Through click chemistry, additional functional group mPEG2000 can be easily introduced into these conjugates. The introduction of mPEG2000 fragment resulted in the formation of nanoparticles 1a and 1b (average particle sizes were 216.9 and 257.9 nm, respectively) with significantly increased water solubility (more than 19 000-fold). The release of therapeutic drug SN-38 in the presence of CTB was confirmed by HPLC and prodrug 1a showed potent in vitro cytotoxicity against all tested cell lines. Impressively, compared with irinotecan, CTB sensitive prodrug 1a displayed similar in vivo efficacy with remarkable decreased in vivo toxicity. PMID:27070848

  10. Chapter 12. Space Heating Equipment

    Energy Technology Data Exchange (ETDEWEB)

    Rafferty, Kevin D.

    1998-01-01

    The performance evaluation of space heating equipment for a geothermal application is generally considered from either of two perspectives: (a) selecting equipment for installation in new construction, or (b) evaluating the performance and retrofit requirements of an existing system. With regard to new construction, the procedure is relatively straightforward. Once the heating requirements are determined, the process need only involve the selection of appropriately sized hot water heating equipment based on the available water temperature. It is important to remember that space heating equipment for geothermal applications is the same equipment used in non-geothermal applications. What makes geothermal applications unique is that the equipment is generally applied at temperatures and flow rates that depart significantly from traditional heating system design. This chapter presents general considerations for the performance of heating equipment at non-standard temperature and flow conditions, retrofit of existing systems, and aspects of domestic hot water heating.

  11. Quantum Simulations of Solvated Biomolecules Using Hybrid Methods

    Science.gov (United States)

    Hodak, Miroslav

    2009-03-01

    One of the most important challenges in quantum simulations on biomolecules is efficient and accurate inclusion of the solvent, because the solvent atoms usually outnumber those in the biomolecule of interest. We have developed a hybrid method that allows for explicit quantum-mechanical treatment of the solvent at low computational cost. In this method, Kohn-Sham (KS) density functional theory (DFT) is combined with an orbital-free (OF) DFT. Kohn-Sham (KS) DFT is used to describe the biomolecule and its first solvation shells, while the orbital-free (OF) DFT is employed for the rest of the solvent. The OF part is fully O(N) and capable of handling 10^5 solvent molecules on current parallel supercomputers, while taking only ˜ 10 % of the total time. The compatibility between the KS and OF DFT methods enables seamless integration between the two. In particular, the flow of solvent molecules across the KS/OF interface is allowed and the total energy is conserved. As the first large-scale applications, the hybrid method has been used to investigate the binding of copper ions to proteins involved in prion (PrP) and Parkinson's diseases. Our results for the PrP, which causes mad cow disease when misfolded, resolve a contradiction found in experiments, in which a stronger binding mode is replaced by a weaker one when concentration of copper ions is increased, and show how it can act as a copper buffer. Furthermore, incorporation of copper stabilizes the structure of the full-length PrP, suggesting its protective role in prion diseases. For alpha-synuclein, a Parkinson's disease (PD) protein, we show that Cu binding modifies the protein structurally, making it more susceptible to misfolding -- an initial step in the onset of PD. In collaboration with W. Lu, F. Rose and J. Bernholc.

  12. Design and evaluation of a PEGylated lipopeptide equipped with drug-interactive motifs as an improved drug carrier.

    Science.gov (United States)

    Zhang, Peng; Lu, Jianqin; Huang, Yixian; Zhao, Wenchen; Zhang, Yifei; Zhang, Xiaolan; Li, Jiang; Venkataramanan, Raman; Gao, Xiang; Li, Song

    2014-01-01

    Micelles are attractive delivery systems for hydrophobic drugs due to their small size and the ease of application. However, the limited drug loading capacity and the intrinsic poor stability of drug-loaded formulations represent two major issues for some micellar systems. In this study, we designed and synthesized a micelle-forming PEG-lipopeptide conjugate with two Fmoc groups located at the interfacial region, and two oleoyl chains as the hydrophobic core. The significance of Fmoc groups as a broadly applicable drug-interactive motif that enhances the carrier-drug interaction was examined using eight model drugs of diverse structures. Compared with an analogue without carrying a Fmoc motif, PEG5000-(Fmoc-OA)₂ demonstrated a lower value of critical micelle concentration and three-fold increases of loading capacity for paclitaxel (PTX). These micelles showed tubular structures and small particle sizes (∼70 nm), which can be lyophilized and readily reconstituted with water without significant changes in particle sizes. Fluorescence quenching study illustrated the Fmoc/PTX π-π stacking contributes to the carrier/PTX interaction, and drug-release study demonstrated a much slower kinetics than Taxol, a clinically used PTX formulation. PTX/PEG5000-(Fmoc-OA)₂ mixed micelles exhibited higher levels of cytotoxicity than Taxol in several cancer cell lines and more potent inhibitory effects on tumor growth than Taxol in a syngeneic murine breast cancer model (4T1.2). We have further shown that seven other drugs can be effectively formulated in PEG5000-(Fmoc-OA)₂ micelles. Our study suggests that micelle-forming PEG-lipopeptide surfactants with interfacial Fmoc motifs may represent a promising formulation platform for a broad range of drugs with diverse structures. PMID:24281690

  13. Linkage of biomolecules to solid phases for immunoassay

    International Nuclear Information System (INIS)

    Topics covered by this lecture include a brief review of the principal methods of linkage of biomolecules to solid phase matrices. Copies of the key self explanatory slides are presented as figures together with reprints of two publications by the author dealing with a preferred chemistry for the covalent linkage of antibodies to hydroxyl and amino functional groups and the effects of changes in solid phase matrix and antibody coupling chemistry on the performance of a typical excess reagent immunoassay for thyroid stimulating hormone

  14. Synthesis of fullerenic nanocapsules from bio-molecule carbonisation

    Science.gov (United States)

    Tsang, Shik Chi; Qiu, Jieshan; Harris, Peter J. F.; Fu, Qi Jia; Zhang, Ning

    2000-06-01

    There has been great interest in the incorporation of foreign materials into fullerene structures (C 60, nanotubes, nanoparticles, onions). This interest has been driven by the potential applications of the filled fullerenes, which lie in areas as diverse as optical, electronic, magnetic recording materials and nuclear medicine. In particular, the onion structures of extreme strength may offer excellent protection to their encapsulated nanomaterials for applications. Here, we describe controlled carbonisation of an iron-containing biomolecule, ferritin, at elevated temperatures. This simple technique produces macroscopic quantities of quasi-spherical fullerenic shells (onions) that encapsulate iron nanoparticles of a very narrow range of particle diameters.

  15. Low-energy electron scattering from molecules, biomolecules and surfaces

    CERN Document Server

    Carsky, Petr

    2011-01-01

    Since the turn of the 21st century, the field of electron molecule collisions has undergone a renaissance. The importance of such collisions in applications from radiation chemistry to astrochemistry has flowered, and their role in industrial processes such as plasma technology and lighting are vital to the advancement of next generation devices. Furthermore, the development of the scanning tunneling microscope highlights the role of such collisions in the condensed phase, in surface processing, and in the development of nanotechnology.Low-Energy Electron Scattering from Molecules, Biomolecule

  16. Detection of prostate-specific antigen with biomolecule-gated AlGaN/GaN high electron mobility transistors

    International Nuclear Information System (INIS)

    In order to improve the sensitivity of AlGaN/GaN high electron mobility transistor (HEMT) biosensors, a simple biomolecule-gated AlGaN/GaN HEMT structure was designed and successfully fabricated for prostate specific antigen (PSA) detection. UV/ozone was used to oxidize the GaN surface and then a 3-aminopropyl trimethoxysilane (APTES) self-assembled monolayer was bound to the sensing region. This monolayer serves as a binding layer for attachment of the prostate specific antibody (anti-PSA). The biomolecule-gated AlGaN/GaN HEMT sensor shows a rapid and sensitive response when the target prostate-specific antigen in buffer solution was added to the antibody-immobilized sensing area. The current change showed a logarithm relationship against the PSA concentration from 0.1 pg/ml to 0.993 ng/ml. The sensitivity of 0.215% is determined for 0.1 pg/ml PSA solution. The above experimental result of the biomolecule-gated AlGaN/GaN HEMT biosensor suggested that this biosensor might be a useful tool for prostate cancer screening. (paper)

  17. Industrial cogeneration optimization program. Volume II. Appendix A. Conceptual designs and preliminary equipment specifications. Appendix B. Characterization of cogeneration systems (near-term technology). Appendix C. Optimized cogeneration systems

    Energy Technology Data Exchange (ETDEWEB)

    1980-01-01

    This appendix to a report which evaluates the technical, economic, and institutional aspects of industrial cogeneration for conserving energy in the food, chemical, textile, paper, and petroleum industries contains data, descriptions, and diagrams on conceptual designs and preliminary equipment specifications for cogeneration facilities; characterization of cogeneration systems in terms of fuel utilization, performance, air pollution control, thermal energy storage systems, and capital equipment costs; and optimized cogeneration systems for specific industrial plants. (LCL)

  18. Identification of Biomolecular Building Blocks by Recognition Tunneling: Stride towards Nanopore Sequencing of Biomolecules

    Science.gov (United States)

    Sen, Suman

    DNA, RNA and Protein are three pivotal biomolecules in human and other organisms, playing decisive roles in functionality, appearance, diseases development and other physiological phenomena. Hence, sequencing of these biomolecules acquires the prime interest in the scientific community. Single molecular identification of their building blocks can be done by a technique called Recognition Tunneling (RT) based on Scanning Tunneling Microscope (STM). A single layer of specially designed recognition molecule is attached to the STM electrodes, which trap the targeted molecules (DNA nucleoside monophosphates, RNA nucleoside monophosphates or amino acids) inside the STM nanogap. Depending on their different binding interactions with the recognition molecules, the analyte molecules generate stochastic signal trains accommodating their "electronic fingerprints". Signal features are used to detect the molecules using a machine learning algorithm and different molecules can be identified with significantly high accuracy. This, in turn, paves the way for rapid, economical nanopore sequencing platform, overcoming the drawbacks of Next Generation Sequencing (NGS) techniques. To read DNA nucleotides with high accuracy in an STM tunnel junction a series of nitrogen-based heterocycles were designed and examined to check their capabilities to interact with naturally occurring DNA nucleotides by hydrogen bonding in the tunnel junction. These recognition molecules are Benzimidazole, Imidazole, Triazole and Pyrrole. Benzimidazole proved to be best among them showing DNA nucleotide classification accuracy close to 99%. Also, Imidazole reader can read an abasic monophosphate (AP), a product from depurination or depyrimidination that occurs 10,000 times per human cell per day. In another study, I have investigated a new universal reader, 1-(2-mercaptoethyl)pyrene (Pyrene reader) based on stacking interactions, which should be more specific to the canonical DNA nucleosides. In addition

  19. Novel in Vitro Efficiency of Chitosan Biomolecule Against Trichomonas Gallinae

    Directory of Open Access Journals (Sweden)

    SH Pourseyed

    2012-02-01

    Full Text Available Background: Development of new natural agents for parasitic diseases treatment has unexpectedly increased to overcome effectively against emergence and re-emergence of parasitic diseases, the appearance of drug resistant organisms and toxic side effects of current agents. The aim of the study was to evaluate antiprotozoal activities of chitosan biomolecule on trophozoites of Trichomonas gallinae.Methods: The antitrichomonal activity of various low molecular weight chitosan concentrations including 125, 250, 500 and 1250 μg ml-1 against T. gallinae trophozoites cultured in trypticase-yeast extract-maltose medium supplemented with heat-inactivated cold horse serum was evaluated in vitro. Samples containing medium without chitosan were also assayed as controls.Results: The mortality rates at 0, 3 and 6 h post treatment with all concentrations were significantly different from control group (P<0.05. Treated trophozoites showed more susceptibility to the highest concentration reaching mortality rate of 100% at 3h post inoculation. However, at this time, results for 125, 250 and 500 μg ml-1 were 93%, 95% and 96.7%, respectively.Conclusion: The results demonstrate that the application of chitosan biomolecule is a promising option for treatment of trichomoniasis in pigeons.

  20. Biosurfactants: Multifunctional Biomolecules of the 21st Century

    Directory of Open Access Journals (Sweden)

    Danyelle Khadydja F. Santos

    2016-03-01

    Full Text Available In the era of global industrialisation, the exploration of natural resources has served as a source of experimentation for science and advanced technologies, giving rise to the manufacturing of products with high aggregate value in the world market, such as biosurfactants. Biosurfactants are amphiphilic microbial molecules with hydrophilic and hydrophobic moieties that partition at liquid/liquid, liquid/gas or liquid/solid interfaces. Such characteristics allow these biomolecules to play a key role in emulsification, foam formation, detergency and dispersal, which are desirable qualities in different industries. Biosurfactant production is considered one of the key technologies for development in the 21st century. Besides exerting a strong positive impact on the main global problems, biosurfactant production has considerable importance to the implantation of sustainable industrial processes, such as the use of renewable resources and “green” products. Biodegradability and low toxicity have led to the intensification of scientific studies on a wide range of industrial applications for biosurfactants in the field of bioremediation as well as the petroleum, food processing, health, chemical, agricultural and cosmetic industries. In this paper, we offer an extensive review regarding knowledge accumulated over the years and advances achieved in the incorporation of biomolecules in different industries.

  1. Biosurfactants: Multifunctional Biomolecules of the 21st Century

    Science.gov (United States)

    Santos, Danyelle Khadydja F.; Rufino, Raquel D.; Luna, Juliana M.; Santos, Valdemir A.; Sarubbo, Leonie A.

    2016-01-01

    In the era of global industrialisation, the exploration of natural resources has served as a source of experimentation for science and advanced technologies, giving rise to the manufacturing of products with high aggregate value in the world market, such as biosurfactants. Biosurfactants are amphiphilic microbial molecules with hydrophilic and hydrophobic moieties that partition at liquid/liquid, liquid/gas or liquid/solid interfaces. Such characteristics allow these biomolecules to play a key role in emulsification, foam formation, detergency and dispersal, which are desirable qualities in different industries. Biosurfactant production is considered one of the key technologies for development in the 21st century. Besides exerting a strong positive impact on the main global problems, biosurfactant production has considerable importance to the implantation of sustainable industrial processes, such as the use of renewable resources and “green” products. Biodegradability and low toxicity have led to the intensification of scientific studies on a wide range of industrial applications for biosurfactants in the field of bioremediation as well as the petroleum, food processing, health, chemical, agricultural and cosmetic industries. In this paper, we offer an extensive review regarding knowledge accumulated over the years and advances achieved in the incorporation of biomolecules in different industries. PMID:26999123

  2. Biosurfactants: Multifunctional Biomolecules of the 21st Century.

    Science.gov (United States)

    Santos, Danyelle Khadydja F; Rufino, Raquel D; Luna, Juliana M; Santos, Valdemir A; Sarubbo, Leonie A

    2016-01-01

    In the era of global industrialisation, the exploration of natural resources has served as a source of experimentation for science and advanced technologies, giving rise to the manufacturing of products with high aggregate value in the world market, such as biosurfactants. Biosurfactants are amphiphilic microbial molecules with hydrophilic and hydrophobic moieties that partition at liquid/liquid, liquid/gas or liquid/solid interfaces. Such characteristics allow these biomolecules to play a key role in emulsification, foam formation, detergency and dispersal, which are desirable qualities in different industries. Biosurfactant production is considered one of the key technologies for development in the 21st century. Besides exerting a strong positive impact on the main global problems, biosurfactant production has considerable importance to the implantation of sustainable industrial processes, such as the use of renewable resources and "green" products. Biodegradability and low toxicity have led to the intensification of scientific studies on a wide range of industrial applications for biosurfactants in the field of bioremediation as well as the petroleum, food processing, health, chemical, agricultural and cosmetic industries. In this paper, we offer an extensive review regarding knowledge accumulated over the years and advances achieved in the incorporation of biomolecules in different industries. PMID:26999123

  3. 基于Zigbee技术的智能教室设备控制系统设计%Smart Classroom Equipment Control System Design Based on Zigbee Technology

    Institute of Scientific and Technical Information of China (English)

    陈海松

    2013-01-01

    随着生活水平的提高及科技进步,智能控制得到越来越广泛的应用。现有教室的灯光、窗帘、风扇等大都是采用手动控制或采用遥控器通过无线射频信号进行控制。文章将ZigBee无线通信技术应用到智能教室设备控制系统的设计中,给出了智能教室设备控制无线网络系统的总体方案和各部分软硬件的设计,并实现用户通过手机或平板电脑以无线Wifi的形式发送控制信号至无线路由器,控制信号经网线到以太网模块后发送至Zigbee模块,Zigbee模块接收控制信号后实现对Zigbee设备的控制。%With the improvement of living standards and the progress of science and technology, intelligent control has been more widely used. The existing classroom lighting, curtains, fans, etc. are controlled based on manual control or remote controller through RF signal. In this paper Zigbee wireless communication technology is applied in the design of the control system design of smart classroom equipment, the overall scheme and various hardware and software designs of the smart classroom equipment control wireless network system are given, and the transmission of the control signal to wireless router is implemented through mobile phone or tablet in Wifi form. The control signal is sent to the Zigbee module through cable to the Ethernet module, and the Zigbee module realizes the control of Zigbee devices by receiving control signal.

  4. Design for coating curing equipment based on short-wave radiation heating%涂层短波强辐射固化设备的设计

    Institute of Scientific and Technical Information of China (English)

    于喜年; 刘军; 赵月红

    2012-01-01

    In the surface painting industry, the application of shortwave radiation heating technology to workpiece surface coating curing system can shorten curing time, enhance energy use efficiency, reduce energy consumption, and improve the coating quality on workpiece surface. In this article, the principle of radiation heating technology is introduced. The essential difference between shortwave radiation heating and convection-conduction heating, as well as the rule for temperature control in the chamber of curing equipment were analyzed. The main components of coating shortwave radiation curing equipment and the design essentials were discussed. The chamber skeleton, radiation heater, and the structure of wind-reversed cycle system were studied.%在表面涂装领域,工件表面涂层固化系统采用短波强辐射固化技术可以缩短涂层固化时间,有效提高热能利用效率,减少能量消耗,提高工件表面涂装质量.本文介绍了强辐射加热技术的原理,分析了短波强辐射加热与对流-传导加热的本质区别以及固化设备室体内温度的控制规律,论述了涂层短波强辐射固化设备的主要组成部分和设计要点,研究了室体骨架、强辐射加热器和微风逆循环系统的结构.

  5. 7 CFR 58.626 - Packaging equipment.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Packaging equipment. 58.626 Section 58.626 Agriculture....626 Packaging equipment. Packaging equipment designed to mechanically fill and close single service... accessible for cleaning. The design and operation of the machine shall in no way contaminate the container...

  6. 基于 Raspberry Pi的α能谱测量装置设计%Design of Alpha Spectrum Measurement Equipment Based on Raspberry Pi

    Institute of Scientific and Technical Information of China (English)

    李文涛; 唐泉; 吴淼; 李连山; 崔爽; 龙慧佳; 冯旭

    2015-01-01

    The paper proposed a design program of αembedded alpha spectrum measurement device based on Raspberry Pi computer.Based on Linux operating system and the Python program, the device realized the re-moteαspectral measurement, real-time display and data storage.Avoiding the operating system migration and driver development in general embedded system development, this design shortens the development period, and the software is compatible with the personal computer and windows operating system.The content includes hard-ware circuit scheme,alpha spectral acquisition board,data transmission and cross platform multithreading spec-trum software design.Tested through the Am -241 source, the repeatability and stability of the measurement equipment meet the requirements.%提出了一种基于Raspberry Pi计算机的嵌入式α能谱测量装置的设计方案,基于Linux操作系统和Python语言编写程序,并利用无线网络远程控制,实现了远程α能谱测量、实时显示和数据保存等功能,软件设计过程避免了操作系统迁移、驱动开发等工作,具有开发周期短,通用于PC机的特点。内容包括α能谱仪的硬件电路、数据传输和跨平台多线程能谱软件的设计。使用241 Am源对测量系统主要性能进行了测试,重复性及稳定性符合要求。

  7. 面向紧急救援的搜救装备产品设计人性化考量%Considerations of Search and Rescue Equipment Product Humanized Design for Emergency Rescue

    Institute of Scientific and Technical Information of China (English)

    钱洪伟

    2015-01-01

    In this paper, the humanized product design preliminary definition of the concept, design, product design, humanization and search and rescue equipment product design humanization, etc.; Architecture of the search and rescue equipment product design problem: the logic of human interpretation interpretation of search and rescue equipment product design humanized nature, characteristics and functions; Based on dynamicexpounds “technology” , build the implementing mechanism of search and rescue equipment humanized product design; And proved by actual case. Studies have shown that the emergency rescue equipment in the product design process is integrated into the human factors, such as efficiency, security, risk factors, directly affect the rescue equipment when using relief effect; Product design if you don ’t consider modularity, removable, etc, in the event of accident, how to product of involved has been put into use forcible entry directly affect the relief progress; This study has important theoretical significance for deepening the research on design philosophy, to guide the search and rescue equipment humanized product design has strong practical significance.%本文对产品设计人性化的相关概念进行了初步的界定:设计、产品设计、人性化以及搜救装备产品设计人性化等;架构了搜救装备产品设计人性化的逻辑阐释问题:诠释了搜救装备产品设计人性化的本质;基于“技术动态过程论“思想,构建了搜救装备产品设计人性化的实现机制。研究表明:应急搜救装备在产品设计环节是否融入人性化因素,如工效、安全风险因素,直接影响救援装备使用时的救灾效果;产品设计时如果不考虑模块化、可拆卸等功能,一旦发生事故,如何对所涉已投入使用的产品进行破拆都直接影响救灾进度。本研究对于深化设计哲学研究具有重要的理论意义,对于引导搜救装备产品设

  8. Transitioning Streaming to Trapping in DC Insulator-based Dielectrophoresis for Biomolecules

    OpenAIRE

    Camacho-Alanis, Fernanda; Gan, Lin; Ros, Alexandra

    2012-01-01

    Exploiting dielectrophoresis (DEP) to concentrate and separate biomolecules has recently shown large potential as a microscale bioanalytical tool. Such efforts however require tailored devices and knowledge of all interplaying transport mechanisms competing with dielectrophoresis (DEP). Specifically, a strong DEP contribution to the overall transport mechanism is necessary to exploit DEP of biomolecules for analytical applications such as separation and fractionation. Here, we present improve...

  9. Cleaning supplies and equipment

    Science.gov (United States)

    ... gov/ency/patientinstructions/000443.htm Cleaning supplies and equipment To use the sharing features on this page, ... to clean supplies and equipment. Disinfecting Supplies and Equipment Start by wearing the right personal protective equipment ( ...

  10. Laser desorption mass spectrometry for biomolecule detection and its applications

    International Nuclear Information System (INIS)

    During the past few years, we developed and used laser desorption mass spectrometry for biomolecule detections. Matrix-assisted laser desorption/ionization (MALDI) was successfully used to detect DNA fragments with the size larger than 3000 base pairs. It was also successfully used to sequence DNA with both enzymatic and chemical degradation methods to produce DNA ladders. We also developed MALDI with fragmentation for direct DNA sequencing for short DNA probes. Since laser desorption mass spectrometry for DNA detection has the advantages of fast speed and no need of labeling, it has a great potential for molecular diagnosis for disease and person identification by DNA fingerprinting. We applied laser desorption mass spectrometry to succeed in the diagnosis of cystic fibrosis and several other nerve degenerative diseases such as Huntington's disease. We also succeeded in demonstrating DNA typing for forensic applications

  11. Synthesis of selenium nanorods with assistance of biomolecule

    Indian Academy of Sciences (India)

    S Kannan; K Mohanraj; K Prabhu; S Barathan; G Sivakumar

    2014-12-01

    Nanorods of one-dimensional (1D) trigonal selenium (t-Se) are synthesized using biomolecule substances for five different aging times (1 h, 2 h, 3 h, 1 day and 4 days) by precipitation method. XRD analysis indicates a shift of the (1 0 1) plane towards higher diffraction angle for 1 day aging time. It is observed that the crystallite size decreases with increase in aging time except for an aging period of 4 days. FTIR analysis confirmed that the presence of stretching and bending vibrations of Se–O in both synthesized and commercial selenium samples at 465, 668 and 1118 cm-1. The FESEM micrographs are evident for the changes of rod size as a function of aging time. It is observed that the optical band gap energy is increased with aging time up to 1 day, whereas it decreases in 4 days aging time.

  12. Vacuum foam drying: An alternative to lyophilization for biomolecule preservation

    Directory of Open Access Journals (Sweden)

    R D Jangle

    2012-01-01

    Full Text Available Vacuum foam drying is evaluated as an alternative for lyophilization for enhanced process and storage stability of bovine serum albumin. The protein protective efficiency of different stabilizers was compared in vacuum foam drying and lyophilization. Sucrose mixtures produced better foam characters than mannitol. Unlike calcium lactate, incorporation of polyvinyl pyrrolidone to sucrose synergistically enhanced the recovery of bovine serum albumin. The conformational stability and bovine serum albumin content further increased with sodium phosphate as compared to potassium phosphate. All sucrose mixtures, except calcium lactate showed large α-helix amide-I band at approximately 1656 cm -1 . The amorphous powder diffraction in case of sodium phosphate monobasic mixture retained maximum bovine serum albumin content. The crystallization of similar mixtures in lyophilization reduced its bovine serum albumin content. Vacuum foam drying showed better processing and storage stability of bovine serum albumin than lyophilization process. Hence vacuum foam drying is short, simple and industrially economical process for biomolecules preservation.

  13. Biomolecule Profiles in Inedible Wild Mushrooms with Antioxidant Value

    Directory of Open Access Journals (Sweden)

    Isabel C.F.R. Ferreira

    2011-05-01

    Full Text Available The use of natural products isolated from mushrooms, included inedible species, against infection, cancer diseases and other oxidative-stress related diseases is one of the cornerstones of modern medicine. In the present work, the antioxidant molecule profiles of inedible mushroom species were evaluated and compared with those of edible species. The order of antioxidant abundance found in inedible wild mushrooms was: phenolics > flavonoids > ascorbic acid > tocopherols > carotenoids, similar to that of edible species. Furthermore the same energetic biomolecules were found including the disaccharide trehalose, the monosaccharide alcohol derivative mannitol and the fatty acids palmitic, oleic and linoleic acids. Fomitopsis pinicola revealed a very high phenolics concentration (388 mg GAE/g extract and powerful antioxidant properties, mainly reducing power (EC50 value 60 μg/mL similar to the standard Trolox®. It could find applications in the prevention of free radical-related diseases as a source of bioactive compounds.

  14. Equipment Design of Electrochemical Bearizing Processing Device%电解扩孔成形加工装置的设计

    Institute of Scientific and Technical Information of China (English)

    张京超; 田明鑫; 徐文骥; 刘新

    2015-01-01

    目前对细长孔进行扩孔加工主要采用机械扩孔的加工方法,存在刀杆易振动、加工轴线易歪斜等问题;而采用电解扩孔方法,则加工精度高、表面质量好,能较好地解决上述问题。设计并搭建的细长孔脉冲电解扩孔成形加工装置为细长阶梯孔脉冲电解扩孔加工奠定了实验条件。%At present,mechanical processing method is the principal method to process slender holes,but many problems exit in this method. For example,the tool is short of rigidity and machining axis is skewed. The machining accuracy and surface quality is good in pulse electrochemical bearizing processing. The pulse electrochemical bearizing machining equipment for slender holes is designed and built. These laid the experimental conditions of pulse electrochemical bearizing for slender holes.

  15. Design and development of an anthropomorphic phantom equipped with detectors in order to evaluate the effective dose E at workplaces: feasibility study

    International Nuclear Information System (INIS)

    My PhD study aims to determine the feasibility to design and develop, for photon fields, an anthropomorphic phantom equipped with detectors in order to evaluate the effective dose E at workplaces. First of all, the energy losses within the organs are calculated using the M.C.N.P.X. Monte Carlo code, in order to determine the detection positions within the different organs. Then, to decrease the number of detection positions, the organ contribution to the effective dose is studied. Finally, the characteristics of the detectors to insert and the characteristics of the phantom to use are deduced. The results show that 24 or 23 detection positions, according to the wT values (publication 60 or new recommendations of the ICRP), give a E estimation with an uncertainty of ±15 % from 50 keV to 4 MeV. Moreover, the interest of such an instrument is underlined while comparing the E estimation by the personal dose equivalent Hp to the E estimation by the instrumented phantom when the phantom is irradiated by point sources (worker in front of a glove box for example). Last, after the detector and phantom characteristic determination, two types of detectors and one type of phantom are selected. However, for the detectors mainly, developments are necessary. Follow up this study, the characterization and the adaptation of the detectors to the project would be interesting. Furthermore, the study to mixed photon-neutrons would be required the needs of the radiological protection community. (author)

  16. Platinum(II) complexes as spectroscopic probes for biomolecules

    Energy Technology Data Exchange (ETDEWEB)

    Ratilla, E.

    1990-09-21

    The use of platinum(II) complexes as tags and probes for biomolecules is indeed advantageous for their reactivities can be selective for certain purposes through an interplay of mild reaction conditions and of the ligands bound to the platinum. The use of {sup 195}Pt NMR as a method of detecting platinum and its interactions with biomolecules was carried out with the simplest model of platinum(II) tagging to proteins. Variable-temperature {sup 195}Pt NMR spectroscopy proved useful in studying the stereodynamics of complex thioethers like methionine. The complex, Pt(trpy)Cl{sup +}, with its chromophore has a greater potential for probing proteins. It is a noninvasive and selective tag for histidine and cysteine residues on the surface of cytochrome c at pH 5. The protein derivatives obtained are separable, and the tags are easily quantitated and differentiated through the metal-to-ligand charge transfer bands which are sensitive to the environment of the tag. Increasing the pH to 7.0 led to the modification by Pt(trpy)Cl{sup +}of Arg 91 in cytochrome c. Further studies with guanidine-containing ligands as models for arginine modification by Pt(trpy)Cl{sup +} showed that guanidine can act as a terminal ligand and as a bridging ligand. Owing to the potential utility of Pt(trpy)L{sup n+} as electron dense probes of nucleic acid structure, interactions of this bis-Pt(trpy){sup 2+} complex with nucleic acids was evaluated. Indeed, the complex interacts non-covalently with nucleic acids. Its interactions with DNA are not exactly the same as those of its precedents. Most striking is its ability to form highly immobile bands of DNA upon gel electrophoresis. 232 refs.

  17. Recent Advances in Protein Extraction and Chiral Separation of Biomolecules

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Reverse micelles create unique environment in organic media. They are capable of solubilizing hydrophilic biomolecules (e.g., proteins, peptides, amino acids, and DNAs) in their aqueous interior. This feature brings about the practical use of biomaterials in organic media because reverse micelles solubilize them with the intrinsic activity. In this paper, we focus on recent two topics concerning protein extraction and chiral separation of biomolecules using liquid membranes. In the first topic, we present recent attempts to extract proteins from an aqueous solution into isooctane using reverse micelles, and some important operational parameters to achieve an efficient protein transfer are discussed. Furthermore, novel function of reverse micelles as a protein activation medium is introduced. In the reverse micellar phase, denatured proreins were completely reactivated in the reverse micellar solution. The reverse micellar technique is found to be a useful tool not only for protein separation but also for protein refolding. Furthermore, we found that a cyclic ligand carixarene has an extraction ability to set up optimum conditions for protein transfer. In the second topic, we have found that a supported liquid membrane (SLM) encapsulating enzymes shows high enantioselectivity (enantioselective excess value is over 96%) in the transport of racemic pharmaceutical compound ibuprofen. A different experiment also suggests that the α-chymotrypsin-catalyzed reactions droved the enantioselective transport of L-phenylalanine based on the enantioselectivity of the enzyme. The SLM encapsulating the surfactant-enzyme complex enabled the highly enantioselective separation of racemic mixtures. It can be envisioned that arrangement of appropriate enzymes in the SLM system will allow enantioselective separation of various useful organic compounds.

  18. 电动汽车电池箱检测工装的结构设计%Structure Design of Battery Box Test Equipment of Electric Car

    Institute of Scientific and Technical Information of China (English)

    崔庆东; 丁丽平; 郭炎杰; 李明道

    2013-01-01

    T he current electric vehicle battery boxes are made of manual inspection and have no battery or load block w hen detectingin the actual situation .In case of this ,this article presents a fully automatic battery box testing equipmentand a detailed statement of the test fixture design process and the typical program .By ana-lysing the advantages and disadvantages of the various options ,it ultimately designs a generic battery box testing automation equipment in this article .T he device implements the electric vehicle battery box automatic testing and evaluation ,w hich can not only reduce the labors intensity ,improve the reliability of the product testing ,credibility and the pre -qualified rate of battery box ,but also greatlyimprove the working efficiency and fill the gap of the industry .%针对目前电动汽车动力电池箱均采用人工检测且检测时不匹配电池或载重块的实际情况,提出了一种全自动化的电池箱检测工装,并详细陈述了检测工装的设计过程及典型方案,通过分析各个方案的优缺点,最终设计出了一种通用的自动化电池箱检测工装;该检测工装实现了电动汽车电池箱自动化检测与评估,不仅减轻了工人的劳动强度,提高了产品检测的可靠性、可信性和电池箱出厂合格率,工作效率也得到了很大的提升,为行业填补了空白。

  19. Oxidative destruction of biomolecules by gasoline engine exhaust products and detoxifying effects of the three-way catalytic converter.

    Science.gov (United States)

    Blaurock, B; Hippeli, S; Metz, N; Elstner, E F

    1992-01-01

    Aqueous solutions of engine exhaust condensation products were derived from cars powered by diesel or four-stroke gasoline engines (with and without three-way catalytic converter). The cars were operated on a static test platform. Samples of the different exhaust solutions accumulated in a Grimmer-type distillation trap (VDI 3872) during standard test programs (Federal Test Procedure) were incubated with important biomolecules. As indicators of reactive oxygen species or oxidative destruction, ascorbic acid, cysteine, glutathione, serum albumin, the enzymes glycerinaldehyde phosphate dehydrogenase and xanthine oxidase, and the oxygen free-radical indicator keto-methylthiobutyrate were used. During and after the incubations, oxygen activation (consumption) and oxidative destruction were determined. Comparison of the oxidative activities of the different types of exhaust condensates clearly showed that the exhaust condensate derived from the four-stroke car equipped with a three-way catalytic converter exhibited by far the lowest oxidative and destructive power. PMID:1283938

  20. On-chip micro-electromagnets for magnetic-based bio-molecules separation

    Energy Technology Data Exchange (ETDEWEB)

    Ramadan, Qasem E-mail: qasem@pmail.ntu.edu.sg; Samper, Victor; Poenar, Daniel; Yu Chen

    2004-10-01

    This paper reports a comprehensive theoretical, finite element and measurement analysis of different designs of planar micro-electromagnets for bio-molecular manipulation. The magnetic field due to current flowing in complex shapes of current-carrying conductors have been calculated analytically, simulated using finite-element analysis (FEA), and measured using the superconducting quantum interference device technique (SQUID). A comparison of the theoretical and measured magnetic field strength and patterns is presented. The planar electromagnets have been fabricated using patterned Al 2 {mu}m thick. The aim of the study is to explore and optimize the geometrical and structural parameters of planar electromagnets that give rise to the highest magnetic fields and forces for magnetic micro-beads manipulation. Magnetic beads are often used in biochemical assays for separation of bio-molecules. Typical beads are 0.2-10 {mu}m in diameter and have superparamagnetic properties. Increasing the intensity of the magnetic field generated by a coil by injection a larger current is not the most suitable solution as the maximum current is limited by Joule heating. Consequently, in order to maximize the field for a given current, one should optimize the geometry of the coil, as this is an extremely significant factor in determining the magnetic field intensity in 2D planar designs. The theoretical and measured results of this work show that the meander micro-electromagnet with mesh-shaped winding profile produces the strongest magnetic field (about 2.7 {mu}T for a current intensity of 6 mA) compared with other meander designs, such as the serpentine and rosette-shaped ones. The magnetic fields of these three types of meander-shaped micro-electromagnets were compared theoretically with that produced by a spiral micro-electromagnet whose technological realization is more complicated and costly due to the fact that it requires an additional insulation layer with a contact window and

  1. Scientific Equipment Division - Overview

    International Nuclear Information System (INIS)

    Full text: The Scientific Equipment Division consists of the Design Group and the Mechanical Workshop. The activity of the Division includes the following: - designing of devices and equipment for experiments in physics, their mechanical construction and assembly. In particular, there are vacuum chambers and installations for HV and UHV; - maintenance and upgrading of the existing installations and equipment in our Institute; - participation of our engineers and technicians in design works, equipment assembly and maintenance for experiments in foreign laboratories. The Design Group is equipped with PC-computers and AutoCAD graphic software (release 2000 and Mechanical Desktop 4.0) and a AO plotter, what allows us to make drawings and 2- and 3-dimensional mechanical documentation to the world standards. The Mechanical Workshop can offer a wide range of machining and treatment methods with satisfactory tolerances and surface quality. It offers the following possibilities: - turning - cylindrical elements of a length up to 2000 mm and a diameter up to 400 mm, and also disc-type elements of a diameter up to 600 mm and a length not exceeding 300 mm; - milling - elements of length up to 1000 mm and gear wheels of diameter up to 300 mm; - grinding - flat surfaces of dimensions up to 300 mm x 1000 mm and cylindrical elements of a diameter up to 200 mm and a length up to 800 mm; - drilling - holes of a diameter up to 50 mm; - welding - electrical and gas welding, including TIG vacuum-tight welding; - soft and hard soldering; - mechanical works including precision engineering; - plastics treatment - machining and polishing using diamond milling, modelling, lamination of various shapes and materials, including plexiglas, scintillators and light-guides; - painting - paint spraying with possibility of using furnace-fred drier of internal dimensions of 800 mm x 800 mm x 800 mm. Our workshop posses CNC milling machine which can be used for machining of work-pieces up to 500 kg

  2. Equipment Obsolescence Management Program

    International Nuclear Information System (INIS)

    Nuclear Power Plant (NPP) Operators are challenged with securing reliable supply channels for safety related equipment due to equipment obsolescence. Many Original Equipment Manufacturers (OEMs) have terminated production of spare parts and product life-cycle support. The average component life cycles are much shorter than the NPP design life, which means that replacement components and parts for the original NPP systems are not available for the complete design life of the NPPs. The lack or scarcity of replacement parts adversely affects plant reliability and ultimately the profitability of the affected NPPs. This problem is further compounded when NPPs pursue license renewal and approval for plant-life extension. A reliable and predictable supply of replacement co components is necessary for NPPs to remain economically competitive and meet regulatory requirements and guidelines. Electrical and I and C components, in particular, have short product life cycles and obsolescence issues must be managed pro actively and not reactively in order to mitigate the risk to the NPP to ensure reliable and economic NPP operation. (Author)

  3. 基于Prolog语言的装备维修决策专家系统设计与开发%The Design and Development for Equipment Maintenance Decision-Making Expert System Based on Prolog Language

    Institute of Scientific and Technical Information of China (English)

    王广彦; 胡起伟; 王亚彬

    2012-01-01

    The equipment maintenance decision-making expert system is designed and developed based on Prolog intelligent language. The characteristics of equipment maintenance experts are researched thoroughly from the sides of maintenance knowledge and inferential ability. The basic syntaxes and inferential formats of expert system based on Prolog are analyzed, as well as their applications in equipment maintenance. The element knowledge database, correlative knowledge database, and application knowledge database are designed and developed for equipment maintenance decision-making expert system. At last a equipment maintenance decision-making expert system is developed through combinatorial programming of Visual Prolog and VC++.%采用Prolog智能语言对装备维修决策专家系统进行了设计与开发。从维修知识和推理能力两方面研究了装备维修专家的基本特点;分析了基于Prolog的专家系统的基本语法、推理方式及其在装备维修中的应用方式;设计并开发了装备维修决策专家系统的元知识库、关联知识库和应用知识库;最后采用Visual Prolog和VC++混合编程方式开发了某装备维修决策专家系统。

  4. 太阳能温室装备化的构想与新设计%The idea of solar greenhouse equipment and new design

    Institute of Scientific and Technical Information of China (English)

    文麒麟; 石能文; 郑宏飞; 文鹏

    2012-01-01

      温室是解决农产品跨季节生长和地域性紧缺的有效途径,在温室中配置太阳能集热和储能单元构成储能型太阳能温室可以改善作物的微气候,同时可以保证作物在高寒地区寒冷季节正常生长。文章系统综述了储能型太阳能温室技术的发展,介绍了近几年温室技术与太阳能技术的结合情况,分析储能型太阳能温室技术的发展趋势,提出储能型太阳能温室装备化的构想,给出了一个新设计结构,为太阳能在农业生产上的利用提供借鉴。%  The greenhouse is an effective way to solve inter-seasonal growth of agricultural products and regional shortage. Configuration of solar collectors and energy storage unit storage-type solar greenhouse can improve the microclimate of the crop in the greenhouse, at the same time, can guarantee the normal growth of crops in the cold season and the cold region. In the article,development of storage type solar greenhouse technology was systematically summarized, the combination of the recent years' greenhouse technology and solar energy technology were introduced, the development trend of energy storage type solar greenhouse technology was analyzed, the idea of the equipment of energy storage type solar greenhouse was put forward, and a new design structure was gave, so reference was provided for agricultural production use.

  5. 铝合金桁架环缝自动焊机的研制%Design and manufacture of automatic circumferential welding equipment for aluminium alloy boom

    Institute of Scientific and Technical Information of China (English)

    田松亚; 封艳

    2012-01-01

    根据铝合金桁架铝合金管材与接头环缝焊接要求,设计并制造了一台专用焊接设备.根据焊接时序要求,采用可编程控制器实现对焊接设备逻辑顺序的控制,并制定了铝合金桁架铝合金管材与接头环缝的惰性气体保护焊MIG自动焊接工艺.结果表明,该焊机自动化程度高、性能稳定、操作简便,能够满足铝桁架铝合金管材与接头环缝自动焊生产要求,同时提高了生产率.依据制定的焊接工艺,进行了焊接试验.焊接试验表明,制定的工艺所获得的铝合金桁架铝合全管材与接头对接接头,满足焊缝质量要求.%According to the requirements of aluminium alloy boom circumferential welding,this paper design and manufacture a special automatic welding equipment.In terms of weld time sequence requirement,PLC is used to implement the control of welding device logical subsequence.besides.work out the MIG automatic welding procedure of circumferential welding.The Result shows that the welding device displays high degree of automation,stable performance and convenient movement,which could satisfy production requirements of aluminium alloy boom automatic circumferential welding and improve productivity .Based on the welding procedure, welding experiment is done.The result indicates that welding procedure could reach the quality requirements of welding joint.

  6. Electrical steel sheet for eco-design of electrical equipments; Denji gohan de eco dezain. Sho enerugi, soon teigen, jiki shirudo

    Energy Technology Data Exchange (ETDEWEB)

    Kubota, T.; Fujikura, M.; Mizokami, M.; Ushigami, Y.

    1998-05-31

    Electrical steel sheet is a soft magnetic material used for cores of electrical equipments, such as generators, transformers, motors and so on. It is also used for magnetic shielding materials. The progress of not only material properties, but also performance assembled in electrical equipment and magnetic shielding are remarkable. Electrical steel sheet is going to develop as an eco-material for saving energy,reducing noise, and as a magnetic shielding. (author)

  7. Si Nanopores Development for External Control of Transport of Biomolecules

    Energy Technology Data Exchange (ETDEWEB)

    Ileri, N; Tringe, J; Letant, S; Palozoglu, A; Stroeve, P; Faller, R

    2008-06-13

    Nazar Ileri has been involved in an independent, multidisciplinary effort to create a new class of molecular sieves for proteins and viruses. Her experimental work has been performed concurrently at two campuses, LLNL and UC Davis, while theoretical components have been largely accomplished at UC Davis. As will be described, the devices she is creating have great potential to improve very significantly the efficiency and selectivity of molecular transport over what is presently available from state-of-the-art membranes. Our biotechnology training program is based on an integrated study of the transport of biomolecules through conically-shaped, nanoporous silicon membranes. The overall objective of this effort is to demonstrate an efficient, highly selective membrane technology that is manufacturable for macroscopic areas and can be employed in sensing, diagnostic and biomedical applications. Our specific aims are to (1) fabricate and characterize the physical characteristics of the membranes, (2) to demonstrate their utility for molecular transport and separation, and (3) to develop models that will facilitate understanding of these devices as well as improved performance of the next generation of devices. We have proposed that the conical pores have superior performance characteristics compared to other porous filters. To study this hypothesis, complementary approaches from different disciplines, such as membrane synthesis, experiment, and molecular simulation need to be combined. This provides an ideal training environment for a future leader in biotechnology. Hence, for this study, Nazar Ileri has started to carry out a full range of experimental and theoretical investigations under our guidance. First, she has begun fabrication of filters with conical/pyramidal pores. She characterized the pores by AFM and SEM, and analyzed the images using wavelets and other mathematical tools. She has also started to conduct biomolecule transport experiments to compare the

  8. Cold atmospheric plasma sterilization: from bacteria to biomolecules

    Science.gov (United States)

    Kong, Michael

    2009-10-01

    Although ionized gases have been known to have biological effects for more than 100 years, their impact on the practice in healthcare service became very significant only recently. Today, plasma-based surgical tools are used for tissue reduction and blood coagulation as surgical procedures. Most significant however is the speed at which low-temperature gas plasmas are finding new applications in medicine and biology, including plasma sterilization, wound healing, and cancer therapies just to name a few. In the terminology of biotechnology, the ``pipeline'' is long and exciting. This presentation reviews the current status of the field with a particular emphasis on plasma inactivation of microorganisms and biomolecules, for which comprehensive scientific evidence has been obtained. Some of the early speculations of biocidal plasma species are now being confirmed through a combination of optical emission spectroscopy, laser-induced fluorescence, mass spectrometry, fluid simulation and biological sensing with mutated bacteria. Similarly, fundamental studies are being performed to examine cell components targeted by gas plasmas, from membrane, through lipid and membrane proteins, to DNA. Scientific challenge is significant, as the usual complexity of plasma dynamics and plasma chemistry is compounded by the added complication that cells are live and constantly evolving. Nevertheless, the current understanding of plasma inactivation currently provides strong momentum for plasma decontamination technologies to be realized in healthcare. We will discuss the issue of protein and tissue contaminations of surgical instruments and how cold atmospheric plasmas may be used to degrade and reduce their surface load. In the context of plasma interaction with biomolecules, we will consider recent data of plasma degradation of adhesion proteins of melanoma cells. These adhesion proteins are important for cancer cell migration and spread. If low-temperature plasmas could be used to

  9. Si Nanopores Development for External Control of Transport of Biomolecules

    International Nuclear Information System (INIS)

    Nazar Ileri has been involved in an independent, multidisciplinary effort to create a new class of molecular sieves for proteins and viruses. Her experimental work has been performed concurrently at two campuses, LLNL and UC Davis, while theoretical components have been largely accomplished at UC Davis. As will be described, the devices she is creating have great potential to improve very significantly the efficiency and selectivity of molecular transport over what is presently available from state-of-the-art membranes. Our biotechnology training program is based on an integrated study of the transport of biomolecules through conically-shaped, nanoporous silicon membranes. The overall objective of this effort is to demonstrate an efficient, highly selective membrane technology that is manufacturable for macroscopic areas and can be employed in sensing, diagnostic and biomedical applications. Our specific aims are to (1) fabricate and characterize the physical characteristics of the membranes, (2) to demonstrate their utility for molecular transport and separation, and (3) to develop models that will facilitate understanding of these devices as well as improved performance of the next generation of devices. We have proposed that the conical pores have superior performance characteristics compared to other porous filters. To study this hypothesis, complementary approaches from different disciplines, such as membrane synthesis, experiment, and molecular simulation need to be combined. This provides an ideal training environment for a future leader in biotechnology. Hence, for this study, Nazar Ileri has started to carry out a full range of experimental and theoretical investigations under our guidance. First, she has begun fabrication of filters with conical/pyramidal pores. She characterized the pores by AFM and SEM, and analyzed the images using wavelets and other mathematical tools. She has also started to conduct biomolecule transport experiments to compare the

  10. 123I and 13I purification for biomolecules labelling

    International Nuclear Information System (INIS)

    The 123I and 131I are iodine radioisotopes widely used in Nuclear Medicine. The radioisotope 123I is used in diagnosis through the SPECT technique and is routinely produced at IPEN in cyclotron through the reaction: '124Xe (p, 2n) '123Cs -> 123Xe -> 123I. The radioisotope 131I is used both in diagnosis and therapy due to its physical characteristics of decay by β- and its γ-ray emissions that are softened with the use of specific collimators for diagnosis. It is routinely produced at IPEN using the nuclear reactor through the indirect reaction: 130Te (n, γ) ->131Te -> 131I, irradiating compounds containing Te. The radiopharmaceuticals prepared with these radioisotopes go through rigorous quality control tests and the chemical purity of the primary radioisotopes 123I and 131I are within the permissible limits currently defined. However, the presence of some chemical contaminants can prejudice the biomolecules labeling (monoclonal antibodies and peptides), that will produce radiopharmaceuticals of first generation to the oncology area. The aim of this work was to obtain a new purification method of these radioisotopes, allowing the labeling of biomolecules and also to established a process control on those radioisotopes. The methodology was separated on 3 steps: Evaluation of '123I e 131I radionuclidic purity using a hyper pure germanium detector, chemical purity using ICP-OES and the retention and elution study of 131I in several absorbers to choose the most appropriate for the purification tests analyzing the behavior of the possible contaminants. The radionuclidic analyses showed the presence of Te and Co on 131I samples and Te, Tc e Co on 123I samples. The chemical purity analyses showed the presence of Al and Mo in 123I, coming from the window material of the target holder and the presence of Al and Te in 131I samples, coming from the target holder and the target, respectively. The retention and elution study selected the most promising adsorber to the

  11. 无缝钢管水淬火设备的水系统设计及应用%Design and Application of Water System for Water-Quenching Equipment in Seamless Steel Pipes

    Institute of Scientific and Technical Information of China (English)

    曹金娣; 张平; 赵会

    2014-01-01

    The composition and layout of the water system of seamless steel tube water quenching equip-ment are introduced,the calcualtion and theoretical basis of the part in design are discussed,which can provide reference for practical application.%介绍无缝钢管水淬火设备的水系统组成及布置,简述该部分在研发设计中的计算及理论依据,可为实际应用提供参考。

  12. 7 CFR 51.58 - Equipment.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Equipment. 51.58 Section 51.58 Agriculture Regulations... Requirements for Plants Operating Under Continuous Inspection on A Contract Basis § 51.58 Equipment. All equipment used for receiving, washing, grading, packaging or storing shall be of such design, material...

  13. Aircraft Wiring Support Equipment Integration Laboratory (AWSEIL)

    Data.gov (United States)

    Federal Laboratory Consortium — Purpose: The Aircraft Wiring Support Equipment Integration Laboratory (AWSEIL) provides a variety of research, design engineering and prototype fabrication services...

  14. 14 CFR 23.1451 - Fire protection for oxygen equipment.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Fire protection for oxygen equipment. 23... Equipment Miscellaneous Equipment § 23.1451 Fire protection for oxygen equipment. Oxygen equipment and lines... in, or escape from, any designated fire zone. (c) Be installed so that escaping oxygen cannot come...

  15. Proceedings of FED remote maintenance equipment workshop

    International Nuclear Information System (INIS)

    A workshop was convened in two sessions in January and March 1981, on the remote maintenance equipment for the Fusion Engineering Device (FED). The objectives of the first session were to familiarize the participants with the status of the design of the FED and to develop a remote maintenance equipment list for the FED. The objective of the second session was to have the participants present design concepts for the equipment which had been identified in the first session. The equipment list was developed for general purpose and special purpose equipment. The general purpose equipment was categorized as manipulators and other, while the special purpose equipment was subdivided according to the reactor subsystem it serviced: electrical, magnetic, and nuclear. Both mobile and fixed base manipulators were identified. Handling machines were identified as the major requirement for special purpose equipment

  16. Containment and Surveillance Equipment Compendium

    International Nuclear Information System (INIS)

    The Containment and Surveillance Equipment Compendium contains information sections describing the application and status of seals, optical surveillance systems, and monitors for international safeguards systems. The Compendium is a collection of information on equipment in use (generally by the IAEA) or under development in the US in diverse programs being conducted at numerous facilities under different sponsors. The Compendium establishes a baseline for the status and applications of C/S equipment and is a tool to assist in the planning of future C/S hardware development activities. The Appendix contains design concepts which can be developed to meet future goals

  17. TRANSPORT AND EMPLACEMENT EQUIPMENT DESCRIPTIONS

    International Nuclear Information System (INIS)

    The objective and the scope of this document are to list and briefly describe the major mobile equipment necessary for waste package (WP) Transport and Emplacement in the proposed subsurface nuclear waste repository at Yucca Mountain. Primary performance characteristics and some specialized design features of the equipment are explained and summarized in the individual subsections of this document. The Transport and Emplacement equipment described in this document consists of the following: (1) WP Transporter; (2) Reusable Rail Car; (3) Emplacement Gantry; (4) Gantry Carrier; and (5) Transport Locomotive

  18. Equipment for ion beam production

    International Nuclear Information System (INIS)

    An equipment has been designed to extend the scope of control of ion beam flux for an intensive ion beam source used for plasma injection in magnetic vessels. The control equipment is connected to the electromagnet power supply. A consumption regulator is fitted in the operating gas supply to the hollow cathode of the ion source. A circuit is also included for discharge voltage maintenance consisting of a control element and a discharge voltage pick-up. (M.D.). 1 fig

  19. Design and Realization of Leasing Management System of Medical Equipment in Hospital%医疗设备租赁管理系统的设计与实现

    Institute of Scientific and Technical Information of China (English)

    黄志伟; 邹蓉博

    2011-01-01

    Based on the requirement of Device Department in hospital, we designed a leasing management system of the medical equipment in hospital. The system not only improved the equipment' s utility rate, reduced the cost, but also understood the use of instruments, provided reliable and stable medical equipment for clinical.%本文根据医院设备科的实际需求,设计开发了一套医院内部医疗设备租赁管理系统.该系统的应用不仅提高了医疗仪器的使用率,降低了成本,更重要的是能够及时提供全院仪器的租赁使用情况,为临床科室提供可靠、稳定的医疗设备相关信息.

  20. Polyacrylamide medium for the electrophoretic separation of biomolecules

    Science.gov (United States)

    Madabhushi, Ramakrishna S.; Gammon, Stuart A.

    2003-11-11

    A polyacryalmide medium for the electrophoretic separation of biomolecules. The polyacryalmide medium comprises high molecular weight polyacrylamides (PAAm) having a viscosity average molecular weight (M.sub.v) of about 675-725 kDa were synthesized by conventional red-ox polymerization technique. Using this separation medium, capillary electrophoresis of BigDye DNA sequencing standard was performed. A single base resolution of .about.725 bases was achieved in .about.60 minute in a non-covalently coated capillary of 50 .mu.m i.d., 40 cm effective length, and a filed of 160 V/cm at 40.degree. C. The resolution achieved with this formulation to separate DNA under identical conditions is much superior (725 bases vs. 625 bases) and faster (60 min. vs. 75 min.) to the commercially available PAAm, such as supplied by Amersham. The formulation method employed here to synthesize PAAm is straight-forward, simple and does not require cumbersome methods such as emulsion polymerizaiton in order to achieve very high molecular weights. Also, the formulation here does not require separation of PAAm from the reaction mixture prior to reconstituting the polymer to a final concentration. Furthermore, the formulation here is prepared from a single average mol. wt. PAAm as opposed to the mixture of two different average mo. wt. PAAm previously required to achieve high resolution.

  1. Hybrid carbon nanomaterials for electrochemical detection of biomolecules

    Science.gov (United States)

    Laurila, Tomi

    2015-09-01

    Electrochemical detection of different biomolecules in vivo is a promising path towards in situ monitoring of human body and its functions. However, there are several major obstacles, such as sensitivity, selectivity and biocompatiblity, which must be tackled in order to achieve reliably and safely operating sensor devices. Here we show that by utilizing hybrid carbon materials as electrodes to detect two types of neurotransmitters, dopamine and glutamate, several advantages over commonly used electrode materials can be achieved. In particular, we will demonstrate here that it is possible to combine the properties of different carbon allotropes to obtain hybrid materials with greatly improved electrochemical performance. Three following examples of the approach are given: (i) diamond-like carbon (DLC) thin film electrodes with different layer thicknesses, (ii) multi-walled carbon nanotubes grown directly on top of DLC and (iii) carbon nanofibres synthesized on top of DLC thin films. Detailed structural and electrochemical characterization is carried out to rationalize the reasons behind the observed behvior. In addition, results from the atomistic simulations are utilized to obtain more information about the properties of the amorphous carbon thin films.

  2. Radiation damage of biomolecules (RADAM) database development: current status

    International Nuclear Information System (INIS)

    Ion beam therapy offers the possibility of excellent dose localization for treatment of malignant tumours, minimizing radiation damage in normal tissue, while maximizing cell killing within the tumour. However, as the underlying dependent physical, chemical and biological processes are too complex to treat them on a purely analytical level, most of our current and future understanding will rely on computer simulations, based on mathematical equations, algorithms and last, but not least, on the available atomic and molecular data. The viability of the simulated output and the success of any computer simulation will be determined by these data, which are treated as the input variables in each computer simulation performed. The radiation research community lacks a complete database for the cross sections of all the different processes involved in ion beam induced damage: ionization and excitation cross sections for ions with liquid water and biological molecules, all the possible electron – medium interactions, dielectric response data, electron attachment to biomolecules etc. In this paper we discuss current progress in the creation of such a database, outline the roadmap of the project and review plans for the exploitation of such a database in future simulations.

  3. Atomic level analysis of biomolecules by the scanning atom probe

    International Nuclear Information System (INIS)

    Utilizing the unique features of the scanning atom probe (SAP) the binding states of the biomolecules, leucine and methionine, are investigated at atomic level. The molecules are mass analyzed by detecting a single atom and/or clustering atoms field evaporated from a specimen surface. Since the field evaporation is a static process, the evaporated clustering atoms are closely related with the binding between atoms forming the molecules. For example, many thiophene radicals are detected when polythiophene is mass analyzed by the SAP. In the present study the specimens are prepared by immersing a micro cotton ball of single walled carbon nanotubes (SWCNT) in the leucine or methionine solution. The mass spectra obtained by analyzing the cotton balls exhibit singly and doubly ionized carbon ions of SWCNT and the characteristic fragments of the molecules, CH3, CHCH3, C4H7, CHNH2 and COOH for leucine and CH3, SCH3, C2H4, C4H7, CHNH2 and COOH for methionine.

  4. Microfluidic Droplet Dehydration for Concentrating Processes in Biomolecules

    Science.gov (United States)

    Anna, Shelley

    2014-03-01

    Droplets in microfluidic devices have proven useful as picoliter reactors for biochemical processing operations such as polymerase chain reaction, protein crystallization, and the study of enzyme kinetics. Although droplets are typically considered to be self-contained, constant volume reactors, there can be significant transport between the dispersed and continuous phases depending on solubility and other factors. In the present talk, we show that water droplets trapped within a microfluidic device for tens of hours slowly dehydrate, concentrating the contents encapsulated within. We use this slow dehydration along with control of the initial droplet composition to influence gellation, crystallization, and phase separation processes. By examining these concentrating processes in many trapped drops at once we gain insight into the stochastic nature of the events. In one example, we show that dehydration rate impacts the probability of forming a specific crystal habit in a crystallizing amino acid. In another example, we phase separate a common aqueous two-phase system within droplets and use the ensuing two phases to separate DNA from an initial mixture. We further influence wetting conditions between the two aqueous polymer phases and the continuous oil, promoting complete de-wetting and physical separation of the polymer phases. Thus, controlled dehydration of droplets allows for concentration, separation, and purification of important biomolecules on a chip.

  5. Investigation of damage mechanism by ionising radiation on biomolecules

    International Nuclear Information System (INIS)

    Occupational radiation hazard is a very controversial subject. Effects from high radiation doses are well known from past experiences. However, hazard from low doses is still a subject that is hotly debated upon until now. The occupational dosimetry used now is based on a macroscopic scale. Lately, microdosimetry is fast gaining recognition as a more superior way of measuring hazard. More importantly, scientists are researching the basic damage mechanism that leads to biological effects by ionising radiation. In this report, a simulation study of the basic damage mechanism is discussed . This simulation is based upon Monte Carlo calculations and using polyuridylic acid (Poly-U) as the DNA model This simulation tries to relate the physics and chemistry of interactions of ionising radiation with biomolecules. The computer codes used in this simulation, OREC and RADLYS were created by Hamm et al. (1983) in Oak Ridge National Laboratory. The biological endpoints in this simulation are the strand break and base release of the DNA, which is the precursor of all biological effects. These results are compared with model studies that had been done experimentally to check the validity of this simulation. The G-values of strand break and base release from this simulation were -2.35 and 2.75 and compared well with results from irradiation experiments by von Sonntag (I 98 7) from Max Plank's Institute, Germany

  6. Quantification of specific bindings of biomolecules by magnetorelaxometry

    Directory of Open Access Journals (Sweden)

    Steinhoff Uwe

    2008-03-01

    Full Text Available Abstract The binding reaction of the biomolecules streptavidin and anti-biotin antibody, both labelled by magnetic nanoparticles (MNP, to biotin coated on agarose beads, was quantified by magnetorelaxometry (MRX. Highly sensitive SQUID-based MRX revealed the immobilization of the MNP caused by the biotin-streptavidin coupling. We found that about 85% of streptavidin-functionalised MNP bound specifically to biotin-agarose beads. On the other hand only 20% of antibiotin-antibody functionalised MNP were specifically bound. Variation of the suspension medium revealed in comparison to phosphate buffer with 0.1% bovine serum albumin a slight change of the binding behaviour in human serum, probably due to the presence of functioning (non heated serum proteins. Furthermore, in human serum an additional non-specific binding occurs, being independent from the serum protein functionality. The presented homogeneous bead based assay is applicable in simple, uncoated vials and it enables the assessment of the binding kinetics in a volume without liquid flow. The estimated association rate constant for the MNP-labelled streptavidin is by about two orders of magnitude smaller than the value reported for free streptavidin. This is probably due to the relatively large size of the magnetic markers which reduces the diffusion of streptavidin. Furthermore, long time non-exponential kinetics were observed and interpreted as agglutination of the agarose beads.

  7. Direct ultimate disposal of spent fuel. Simulation of shaft transport. Proof of state-of-the-art of a conceptual design of a shaft hoisting equipment for a max. payload of 85 t (TA 2)

    International Nuclear Information System (INIS)

    The reported conceptual design is the first of its kind worldwide for design payloads of this dimension, intended for the POLLUX containers. In order to prove the feasibility and thus the licensibility of the hoisting engineering concept, the first project task was to establish the design of the shaft hoisting equipment. The design of the essential components and sub-systems is based on the requirements of the existing safety guides and engineering codes determining the design quantities to be selected. According to a specific catalogue of criteria developed for this purpose, nine existing German hoisting facilities were selected as reference systems. The criteria are: establishment of a database allowing verification, site variance, payloads and rope loads, rope diameters, design type, number of ropes, performance conditions. The report explains the structural members, components and processes that could be tested and verified by existing reference facilities, and those which remained to be designed and verified in the completely new approach. (orig./HP)

  8. Personal protective equipment

    International Nuclear Information System (INIS)

    This Practical Radiation Technical Manual is one of a series that has been designed to provide guidance on radiological protection for employers, radiation protection officers, managers and other technically competent persons who have responsibility for ensuring the safety of employees working with ionizing radiation. The Manual may be used with the appropriate IAEA Practical Radiation Safety Manuals to provide training, instruction and information for all employees engaged in work with ionizing radiation. Personal protective equipment (PPE) includes clothing or other special equipment that is issued to individual workers to provide protection against actual or potential exposure to ionizing radiations. It is used to protect each worker against the prevailing risk of external or internal exposure in circumstances in which it is not reasonably practicable to provide complete protection by means of engineering controls or administrative methods. Adequate personal protection depends on PPE being correctly selected, fitted and maintained. Appropriate training for the users and arrangements to monitor usage are also necessary to ensure that PPE provides the intended degree of protection effectively. This Manual explains the principal types of PPE, including protective clothing and respiratory protective equipment (RPE). Examples of working procedures are also described to indicate how PPE should be used within a safe system of work. The Manual will be of most benefit if it forms part of a more comprehensive training programme or is supplemented by the advice of a qualified expert in radiation protection. Some of the RPE described in this Manual should be used under the guidance of a qualified expert

  9. Conductive Paper with Antibody-Like Film for Electrical Readings of Biomolecules

    Science.gov (United States)

    Tavares, Ana P. M.; Ferreira, Nádia S.; Truta, Liliana A. A. N. A.; Sales, M. Goreti F.

    2016-01-01

    This work reports a novel way of producing an inexpensive substrate support to assemble a sensing film, designed for the electrical transduction of an intended biomolecule. The support uses cellulose paper as substrate, made hydrophobic with solid wax and covered by a home-made conductive ink having graphite as core material. The hydrophobicity of the paper was confirmed by contact angle measurements and the conductive ink composition was optimized with regard to its adhesion, conductivity, and thermal stability. This support was further modified targeting its application in quantitative analysis. Carnitine (CRT) was selected as target compound, a cancer biomarker. The recognition material consisted of an antibody-like receptor film for CRT, tailored on the support and prepared by electrically-sustained polymerization of 3,4-ethylenedioxythiophene (EDOT) or dodecylbenzenesulfonic acid (DBS). Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy analysis confirmed the presence of the polymeric film on the support, and the performance of the devices was extensively evaluated with regard to linear response ranges, selectivity, applicability, and reusability. Overall, the paper-based sensors offer simplicity of fabrication, low cost and excellent reusability features. The design could also be extended to other applications in electrical-based approaches to be used in point-of-care (POC). PMID:27210055

  10. Conductive Paper with Antibody-Like Film for Electrical Readings of Biomolecules

    Science.gov (United States)

    Tavares, Ana P. M.; Ferreira, Nádia S.; Truta, Liliana A. A. N. A.; Sales, M. Goreti F.

    2016-05-01

    This work reports a novel way of producing an inexpensive substrate support to assemble a sensing film, designed for the electrical transduction of an intended biomolecule. The support uses cellulose paper as substrate, made hydrophobic with solid wax and covered by a home-made conductive ink having graphite as core material. The hydrophobicity of the paper was confirmed by contact angle measurements and the conductive ink composition was optimized with regard to its adhesion, conductivity, and thermal stability. This support was further modified targeting its application in quantitative analysis. Carnitine (CRT) was selected as target compound, a cancer biomarker. The recognition material consisted of an antibody-like receptor film for CRT, tailored on the support and prepared by electrically-sustained polymerization of 3,4-ethylenedioxythiophene (EDOT) or dodecylbenzenesulfonic acid (DBS). Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy analysis confirmed the presence of the polymeric film on the support, and the performance of the devices was extensively evaluated with regard to linear response ranges, selectivity, applicability, and reusability. Overall, the paper-based sensors offer simplicity of fabrication, low cost and excellent reusability features. The design could also be extended to other applications in electrical-based approaches to be used in point-of-care (POC).

  11. Monitoring Framework Design for Logistics Equipment Based on RFID%基于RFID的物流装备信息监控网络平台设计

    Institute of Scientific and Technical Information of China (English)

    刘富春; 周受钦

    2012-01-01

    Containers are the core equipment of the logistics transportation in the world,and over 90 percent of the international transportation is accomplished by containers. The effectiveness of logistics and custom clearance it due to the lag in technology of intelligence and informationization of the container transportation,and unable to monitor in visualized mode. It investigates the developments of the monitoring and management of the smart containers based on the RFID technique,and designs the system platform for internet of things based on the smart containers. This platform can make the overall supply chain information unopposed, and can enhance the effectiveness of the modern logistics. This research provides the perfect product and technique scheme for smart container applications.%集装箱是全球物流运输的核心装备,全球国际货运90%以上都是通过集装箱完成,目前集装箱运输的智能化和信息化技术落后,从而导致物流效率低、海关通关效率低且做不到实时可视化监控.文中基于射频识别和嵌入式徽控制器技术开发了用于托盘和集装箱等物流装备的智能数据采集终端,进而设计了基于智能集装箱的现代物流装备物联网系统平台.该平台的广泛应用使现代物流系统的整个供应链信息流畅通,实现了可视化监控,大幅度提高了现代物流效率.为行业应用提供智能集装箱成熟产品和技术方案.

  12. Design and Simulation of a Var Compensation Equipment%一种无功补偿装置设计与仿真

    Institute of Scientific and Technical Information of China (English)

    闫国琦; 庞树杰; 李继宇

    2012-01-01

    By establishing a non-inductive load filter capacitor current AC-DC switching circuit, the output lags the system voltage by 1/4 cycle of SPWM frequency control method and system to make inductive load energy exchange occurs, to replace the capacitor compensation system inductance inductive successful results. And through the Y/A three-phase transformer connected with the work of the single-phase compensation circuit, eliminating the larger single-phase compensation circuit of 3 harmonics, make compensation circuit excluding low-order harmonic. Based on this principle, a kind of reactive power compensation in power system of power capacitor using inductively instead of control method was proposed, and studies the reactive power compensation device parameters design. To reactive power compensator capacity and voltage, by reducing the impact of the current power capacitor, improving the working reliability and reduce the cost of equipment. Using the circuit simulation software, the compensation effect was tested, and the compensation method was demonstrated.%通过建立一个不含滤波电容的电感负载交直交换流电路,利用输出滞后系统电压1/4工频周期的SPWM控制方法,使电感负载与系统感性负载发生能量交换,达到电感代替电容补偿系统感性无功的效果.并通过Y/△三相变压器连接3个配合工作的单相补偿电路,消去单相补偿电路中较大的3次谐波,使三相补偿电路不含低次谐波.基于该原理,提出一种在电力系统无功补偿中利用电感代替功率电容的控制方法,并研究该无功补偿装置的参数设计.有利于无功补偿器容量和电压的提升,减少由功率电容带来的冲击电流,提高了工作可靠性和降低了设备成本.用仿真软件建立算例电路检验补偿效果,并论证了补偿方法.

  13. The increased safety level for structures, equipment and pipe networks by use of shock, vibration and seismic damping mechanical devices as per SERB -CITON design

    International Nuclear Information System (INIS)

    Full text: The paper presents a solution for diminishing the shocks, vibrations and seismic movements in pipe networks, simultaneously with the reduction of the general stress conditions in piping and supports. The total removal or reduction of vibrations is a hard problem which is not yet managed neither theoretically, through analyses of the occurrence and development of shocks and vibrations in complex systems, nor by experimental studies, because the current supports and dampers cannot provide enough damping within all the frequency ranges met in the current technical domain. Often, the stiffness of classic supports do not allow a satisfactory isolation of the shock and vibration sources as to eliminate their propagation in the environment and to protect the pipe networks and equipment against the shocks and vibrations coming from the surrounding environment. Considering the actual condition met in the nuclear power plants, power plants and thermal power plants, etc this paper represents a major practical aid because it provides new solutions for diminishing the effects of shocks, vibrations and seismic movements. This paper presents the results of the works aiming at diminishing the effects of vibrations in pipe networks, obtained in the design, construction and testing of new types of supports. These include sandwich type components made up of elastic blade packages with controlled distortion provided by the central and peripheral stiff parts called SERB - PIP. With the new type of supports, the control of the distortion at static and dynamic testing and the thermal displacements is achieved by the relative movement between the sandwich structure subassemblies and by the sandwich structure distortion controlled by the central and peripheral distorting parts that generate a non - linear geometric response. These have an easily controllable stiffness and damping, due to their non - linear geometric behaviour. The new type of supports are adjustable to the load

  14. Synthesis of vaterite and aragonite crystals using biomolecules of tomato and capsicum

    Science.gov (United States)

    Chen, Long; Xu, Wang-Hua; Zhao, Ying-Guo; Kang, Yan; Liu, Shao-Hua; Zhang, Zai-Yong

    2012-12-01

    In this paper, biomimetic synthesis of calcium carbonate (CaCO3) in the presence of biomolecules of two vegetables-tomato and capsicum is investigated. Scanning electron microscopy and X-ray powder diffractometry were used to characterize the CaCO3 obtained. The biomolecules in the extracts of two vegetables are determined by UV-vis or FTIR. The results indicate that a mixture of calcite and vaterite spheres constructed from small particles is produced with the extract of tomato, while aragonite rods or ellipsoids are formed in the presence of extract of capsicum. The possible formation mechanism of the CaCO3 crystals with tomato biomolecules can be interpreted by particle-aggregation based non-classical crystallization laws. The proteins and/or other biomolecules in tomato and capsicum may control the formation of vaterite and aragonite crystals by adsorbing onto facets of them.

  15. Plastic Trash goes Biohybrid"-Rapid and Selective Functionalization of Inert Plastic Surfaces with Biomolecules

    DEFF Research Database (Denmark)

    Schiller, Stefan M; Kambhampati, Dev; Stengel, Gudrun;

    2010-01-01

    The covalent functionalization of "inert" polymers such as polypropylene with biomolecules for biocompatible or biosensor surfaces is challenging. Here we present a powerful approach to covalently modify "inert" macromolecular surfaces with biomacromolecules reusing old plastic material. A special...

  16. Some matters concerned with selecting steam parameters and process-circuit solutions to optimize the parameters of steam turbine equipment and engineering design developments

    Science.gov (United States)

    Kultyshev, A. Yu.; Stepanov, M. Yu.; Polyaeva, E. N.

    2014-12-01

    The possibility and advantages of increasing steam pressure in the steam-turbine low-pressure loop for combined-cycle power plants are considered. The question about the advisability of developing and manufacturing steam turbines for being used in combined-cycle power units equipped with modern class F gas turbines for supercritical and ultrasupercritical steam parameters is raised.

  17. Cu(I), Ag(I), Cd(II), and Pb(II) binding to biomolecules studied by perturbed angular correlation of $\\gamma$-rays (PAC) spectroscopy

    CERN Multimedia

    Metal ions display diverse functions in biological systems and are essential components in both protein and nucleic acid structure and function, and in control of biochemical reaction paths and signalling. Similarly, metal ions may be used to control structure and function of synthetic biomolecules, and thus be a tool in the design of molecules with a desired function. In this project we address a variety of questions concerning both the function of metal ions in natural systems, in synthetic biomolecules, and the toxic effect of some metal ions. All projects involve other experimental techniques such as NMR, EXAFS, UV-Vis, fluorescence, and CD spectroscopies providing complementary data, as well as interpretation of the experimental data by quantum mechanical calculations of spectroscopic properties. The isotopes to be employed in the proposal are the following: $^{111m}$Cd, $^{111}$Ag, $^{199}$mHg, $^{204m}$Pb, $^{61}$Cu, $^{68m}$Cu

  18. 基于结构-设备动力相互作用的户内式变电站抗震设计优化%Seismic design optimization of an indoor substation with structure-equipments interaction

    Institute of Scientific and Technical Information of China (English)

    韩文庆; 王亚超; 盖超; 李风雷; 刘昊

    2013-01-01

    A nonlinear dynamic response analysis with structure-equipments interaction of an integrative building in 110 kV Huangtun substation is studied. The results are compared with that of no structure-equipments interaction, which show it is necessary to considering structure-equipments interaction in integrative building of indoor substation. Under rare earthquake, the structure-equipments interaction should be considered, because the seismic responses of structure and equipments with consideration of the interaction are larger than those without consideration of the interaction. In this condition, the traditional equivalent load method will be insecure anymore. In the last,some optimization measures and reasonable suggestions about seismic design of structure and equipments are introduced.%结合黄屯110 kV变电站生产综合楼设计实例,在结构-电气设备复合体系中考虑二者相互动力作用,分析复合体系在大震弹塑性阶段的地震响应,并与不考虑相互作用的计算模型比较分析.分析结果表明,在大震作用下,电气设备参与整个复合体系的动力反应,使主结构的地震响应变大,同时电气设备本身的动力作用也变大,如仍采用传统的等效荷载法设计是偏不安全的,最后给出主结构和电气设备抗震设计的合理建议和优化措施.

  19. Further development of overcast equipment

    Energy Technology Data Exchange (ETDEWEB)

    Dahlitz, G.; Scholze, U.

    1987-04-01

    Spoil overcast technology is outlined in surface mines by excavator, mobile transfer conveyor and boom spreader combinations. The technology is regarded as adequate for small to medium sited mines with either thin, disturbed, split or multiple seams. The TAKRAF manufacturer, GDR, produces a variety of spreaders (series A/sub 2/ Rs) and transfer conveyors (series BRs). Spoil removal capacity ranges up to 18,000 m/sup 3//h. Schemes of general spreader design are provided. Technological advantages compared to overburden conveyor bridges are noted. Specifications including conveyor boom length, spreading height, equipment mobility, equipment positioning for multiple bench mining and other aspects are discussed. New TAKRAF mobile transfer conveyors (BRs 1200 to BRs 1600) are being developed with extended spreading booms for direct spoil overcast and low equipment height (to fit beneath belt conveyor booms of other surface mining equipment). 4 refs.

  20. DESIGN AND IMPROVEMENT OF QUENCHING EQUIPMENT FOR LARGE-DIAMETER SEAMLESS STEEL PIPE%大口径无缝钢管淬火设备的设计与改进

    Institute of Scientific and Technical Information of China (English)

    王允刚; 陈涛; 李萍; 卢明亮

    2012-01-01

    介绍扬州诚德铜管有限公司大口径无缝铜管热处理生产线的淬火设备。该设备在研发设计过程中,采用了国内外先进的“外淋+旋转+内喷+喷雾”的淬火工艺,以满足一些特种钢管淬火要求。通过对该淬火设备的工作原理、淬火工艺、结构特点的分析,说明了该设备改进后与原有淬火设备在机械结构、淬火效果、力学性能等方面的不同。生产实践表明,该新增淬火设备具备提升产品附加值的能力。%Description of the quenching equipment of large-diameter seamless steel pipe heat treatment line in Yangzhou Chengde Steel Pipe Co., Ltd. The equipment in the design process, using the advanced "external showering + pipe rotating + internal spraying + fog spraying" quenching process in order to meet some special steel hardening requirements. By analysis of the quenching equipment working principle, quenching process and structural features to demonstrate that the improved quenching equipment is more advanced than the original type with the mechanical structure, quenching effect and the pipe' s mechanical properties. Production practice shows the new design quenching equipment have the ability to enhance the value-added products.

  1. Probes for biomolecules detection based on RET-enhanced fluorescence polarization.

    Science.gov (United States)

    Ren, Dahai; Wang, Jun; Wang, Bin; You, Zheng

    2016-05-15

    Fluorescent probes based on the principle of resonance energy transfer (RET) or the principle of fluorescence polarization (FP) are already used to detect biomolecules independently. However, there were no in-depth studies about the impact of RET on FP. Also, very few studies gave a comprehensive analysis on how to effectively design such a fluorescent probe. Based on the principle of resonance energy transfer (RET), we constructed fluorescent probes (SA-488-sub-nanogold) using streptavidin labeled Alexa488 (SA-488), nanogold and biotinylated substrate peptide (biotin-subpeptide). The influence of the structure and the ingredients of the substrate peptide were discussed. After SA-488 was combined with the biotin-subpeptide and the nanogold, its fluorescence intensity (FI) would be suppressed due to the energy transfer, leading to an increase in its volume and mass. The suppression of the FI led to a decrease in SA-488's effective concentration, and the increase in the volume or mass prolonged the SA-488's rotational relaxation time. Both changes increased SA-488's polarization in the solution. Therefore, the FP performance of the probe is enhanced by the RET. Using the probe, trypsin and biotin were detected by the change in both fluorescence intensity and fluorescence polarization, showing higher reliability, higher sensitivity, and a lower detection limit. PMID:26774994

  2. The Hardware Design of the Measuring Apparatus of the Hydraulic Flattened System for Certain Armament Equipment%某型装备液压调平系统测试设备的硬件设计

    Institute of Scientific and Technical Information of China (English)

    马久河; 何循来; 陈东根

    2011-01-01

    The basic components of the measuring apparatus of the hydraulic flattened system for certain armament equipment were introduced. The basic principle of its hardware design was carried out. The emphasis was on introduction to the realization of the hardware design, including sensors' setting tool design, main-machine hardware design as well as hardware electromagnetism compati-bEity design.%介绍某型装备液压调平系统测试设备的基本组成,拟定其硬件设计的基本原则,重点介绍硬件设计的实现,包括传感器工装设计、主机硬件设计以及硬件电磁兼容性设计。

  3. Effect of membrane hydrophilization on ultrafiltration performance for biomolecules separation

    Energy Technology Data Exchange (ETDEWEB)

    Susanto, H., E-mail: heru.susanto@undip.ac.id [Department of Chemical Engineering, Universitas Diponegoro, Jl. Prof. Sudarto-Tembalang, Semarang (Indonesia); Roihatin, A.; Aryanti, N.; Anggoro, D.D. [Department of Chemical Engineering, Universitas Diponegoro, Jl. Prof. Sudarto-Tembalang, Semarang (Indonesia); Ulbricht, M. [Lehrstuhl fuer Technische Chemie, Universitaet Duisburg-Essen, Germany, Universitaetstr. 5, Essen (Germany)

    2012-10-01

    fouling ultrafiltration (UF) membranes. Black-Right-Pointing-Pointer We characterized the membranes before and after modification. Black-Right-Pointing-Pointer We examined the unmodified and modified membranes for biomolecules filtration. Black-Right-Pointing-Pointer All the modifications changed the membrane characteristics and the membrane performance. Black-Right-Pointing-Pointer All the modifications resulted in UF membranes having higher resistance towards fouling.

  4. Effect of membrane hydrophilization on ultrafiltration performance for biomolecules separation

    International Nuclear Information System (INIS)

    characterized the membranes before and after modification. ► We examined the unmodified and modified membranes for biomolecules filtration. ► All the modifications changed the membrane characteristics and the membrane performance. ► All the modifications resulted in UF membranes having higher resistance towards fouling.

  5. 基于大数据的舰船装备维修保障信息分析系统设计%Design of Ship Equipment Maintenance Information Analysis System Based on Big Data

    Institute of Scientific and Technical Information of China (English)

    李伟; 金国庆

    2016-01-01

    To meet requirements of the information collection ,storage ,analysis and application of the ship equipment maintenance ,the design of analysis system for ship equipment maintenance information based on big data is proposed .The scheme includes four aspects ,including system design ,system structure design ,system function design and system database design .System uses Hadoop cluster component storage ,calculation and analysis of massive amounts of data in the bottom . at the top by interfaces it directly calls the underlying storage and computing power .So functions of data management ,data query ,data analysis and processing for the massive ship equipment maintenance information can be realized .%针对舰船装备维修保障信息采集、存储、分析与应用的需求,提出了基于大数据处理技术的舰船装备维修保障信息分析系统的设计方案。方案中包括系统总体设计、系统结构设计、系统功能设计和系统数据库设计四个方面。系统在底层使用 Hadoop 集群组件存储、计算和分析海量数据信息,在高层通过接口直接透明的调用底层存储与计算能力,从而实现系统对海量舰船装备维修保障信息的基础数据管理、数据统计查询和数据分析处理的功能。

  6. Analysis of the Key Points in Design of Medical Electrical Equipment Based on GB9706.1%基于GB9706.1的医用电气设备的设计要点分析

    Institute of Scientific and Technical Information of China (English)

    李庆雨

    2015-01-01

    In combination with the standard GB 9706.1-2007 Medical Electrical Equipment Part 1:General Safety Requirements, this paper summarized and analyzed the principle and key points in design of medical electrical equipment from the perspective of safety, including design of power supply, application, over-current protection devices, equipment structure and layouts, interfaces as well as the requirements of hazard prevention and bio-safety.%本文主要从安全角度出发,结合标准GB9706.1-2007《医用电气设备第1部分:安全通用要求》,总结并分析了医用电气设备应遵循的设计原则及产品设计阶段需要重点考虑的内容,包括电源部分设计、应用部分设计、过电流保护装置设计、设备结构和布局设计、接口设计、对危险的防护及生物安全性要求。

  7. 基于GB9706.1的医用电气设备的设计要点分析%Analysis of the Key Points in Design of Medical Electrical Equipment Based on GB9706.1

    Institute of Scientific and Technical Information of China (English)

    李庆雨

    2015-01-01

    In combination with the standard GB 9706.1-2007 Medical Electrical Equipment Part 1:General Safety Requirements, this paper summarized and analyzed the principle and key points in design of medical electrical equipment from the perspective of safety, including design of power supply, application, over-current protection devices, equipment structure and layouts, interfaces as well as the requirements of hazard prevention and bio-safety.%本文主要从安全角度出发,结合标准GB9706.1-2007《医用电气设备第1部分:安全通用要求》,总结并分析了医用电气设备应遵循的设计原则及产品设计阶段需要重点考虑的内容,包括电源部分设计、应用部分设计、过电流保护装置设计、设备结构和布局设计、接口设计、对危险的防护及生物安全性要求。

  8. Hydraulic turbines and auxiliary equipment

    Energy Technology Data Exchange (ETDEWEB)

    Luo Gaorong [Organization of the United Nations, Beijing (China). International Centre of Small Hydroelectric Power Plants

    1995-07-01

    This document presents a general overview on hydraulic turbines and auxiliary equipment, emphasizing the turbine classification, in accordance with the different types of turbines, standard turbine series in China, turbine selection based on the basic data required for the preliminary design, general hill model curves, chart of turbine series and the arrangement of application for hydraulic turbines, hydraulic turbine testing, and speed regulating device.

  9. The Design and Implementation of Equipment Requirement Argumentation Project Management System Based on Worklfow%基于工作流的装备需求论证项目管理系统的设计与实现

    Institute of Scientific and Technical Information of China (English)

    陈彦武; 张学波; 高永明; 胡欣杰; 吴止锾

    2014-01-01

    针对目前装备需求论证流程缺少科学的方法论指导、缺少规范的管理机制、信息文档不便于整理、装备需求论证各要素之间相互关系复杂且动态多变等问题,基于工作流技术,设计并实现了一套支持装备需求论证的项目管理系统,该系统能够以在线方式辅助装备需求论证人员基于定义好的论证流程开展武器装备的需求论证工作,并提供了论证进度监控等功能,提高了工作效率,安全性高。%The currently process of equipment requirement argumentation lacks of scientific methodology, lacks of standardized management mechanism, the information and document is not easily to organize, and the interrelationship of various elements of equipment requirement argumentation is complex and dynamic, against these questions, the paper that is based on workflow technology designs and implements a set of project management system which supports equipment requirement argumentation. The system can aid equipment requirement argumentation staff to carry out requirement argumentation studies of equipment on line basing on defined argumentation processes, and provides a function of argumentation progress and other function, improves work efficiency and safety.

  10. Different size biomolecules anchoring on porous silicon surface: fluorescence and reflectivity pores infiltration comparative studies

    Energy Technology Data Exchange (ETDEWEB)

    Giovannozzi, Andrea M.; Rossi, Andrea M. [National Institute for Metrological Research, Thermodynamic Division, Strada delle Cacce 91, 10135 Torino (Italy); Renacco, Chiara; Farano, Alessandro [Ribes Ricecrhe Srl, Via Lavoratori Vittime del Col du Mont 24, 11100 Aosta (Italy); Derosas, Manuela [Biodiversity Srl, Via Corfu 71, 25124 Brescia (Italy); Enrico, Emanuele [National Institute for Metrological Research, Electromagnetism Division, Strada delle Cacce 91, 10135 Torino (Italy)

    2011-06-15

    The performance of porous silicon optical based biosensors strongly depends on material nanomorphology, on biomolecules distribution inside the pores and on the ability to link sensing species to the pore walls. In this paper we studied the immobilization of biomolecules with different size, such as antibody anti aflatoxin (anti Aflatox Ab, {proportional_to}150 KDa), malate dehydrogenase (MDH, {proportional_to}36KDa) and metallothionein (MT, {proportional_to}6KDa) at different concentrations on mesoporous silicon samples ({proportional_to}15 nm pores diameter). Fluorescence measurements using FITC- labeled biomolecules and refractive index analysis based on reflectivity spectra have been employed together to detect the amount of proteins bound to the surface and to evaluate their diffusion inside the pores. Here we suggest that these two techniques should be used together to have a better understanding of what happens at the porous silicon surface. In fact, when pores dimensions are not perfectly tuned to the protein size a higher fluorescence signal doesn't often correspond to a higher biomolecules distribution inside the pores. When a too much higher concentration of biomolecule is anchored on the surface, steric crowd effects and repulsive interactions probably take over and hinder pores infiltration, inducing a small or absent shift in the fringe pattern even if a higher fluorescence signal is registered. (copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  11. Constructing Optimal Coarse-Grained Sites of Huge Biomolecules by Fluctuation Maximization.

    Science.gov (United States)

    Li, Min; Zhang, John Zenghui; Xia, Fei

    2016-04-12

    Coarse-grained (CG) models are valuable tools for the study of functions of large biomolecules on large length and time scales. The definition of CG representations for huge biomolecules is always a formidable challenge. In this work, we propose a new method called fluctuation maximization coarse-graining (FM-CG) to construct the CG sites of biomolecules. The defined residual in FM-CG converges to a maximal value as the number of CG sites increases, allowing an optimal CG model to be rigorously defined on the basis of the maximum. More importantly, we developed a robust algorithm called stepwise local iterative optimization (SLIO) to accelerate the process of coarse-graining large biomolecules. By means of the efficient SLIO algorithm, the computational cost of coarse-graining large biomolecules is reduced to within the time scale of seconds, which is far lower than that of conventional simulated annealing. The coarse-graining of two huge systems, chaperonin GroEL and lengsin, indicates that our new methods can coarse-grain huge biomolecular systems with up to 10 000 residues within the time scale of minutes. The further parametrization of CG sites derived from FM-CG allows us to construct the corresponding CG models for studies of the functions of huge biomolecular systems. PMID:26930392

  12. Room temperature ionic liquids interacting with bio-molecules: an overview of experimental and computational studies

    Science.gov (United States)

    Benedetto, Antonio; Ballone, Pietro

    2016-03-01

    We briefly review experimental and computational studies of room temperature ionic liquids (RTILs) interacting with important classes of biomolecules, including phospholipids, peptides and proteins, nucleic acids and carbohydrates. Most of these studies have been driven by the interest for RTILs applications as solvents. Thus, available experimental data cover primarily thermodynamic properties such as the reciprocal solubility of RTILs and bio-molecules, as well as phase boundaries. Less extensive data are also available on transport properties such as diffusion and viscosity of homogeneous binary (RTILs/biomolecules) and ternary (RTIL/biomolecules/water) solutions. Most of the structural information at the atomistic level, of interest especially for biochemical, pharmaceutical and nanotechnology applications, has been made available by molecular dynamics simulations. Major exceptions to this statement are represented by the results from NMR and circular dichroism spectroscopy, by selected neutron and X-ray scattering data, and by recent neutron reflectometry measurements on lipid bilayers on surfaces, hydrated by water-RTIL solutions. A final section of our paper summarizes new developments in the field of RTILs based on amino acids, that combine in themselves the two main aspects of our discussion, i.e. ionic liquids and bio-molecules.

  13. Anti-cross-infection Design and Standard Requirements of Dental Devices and Equipments%口腔器械设备防交叉感染设计与标准要求

    Institute of Scientific and Technical Information of China (English)

    李丹荣

    2013-01-01

      本文分析了引起口腔临床交叉感染的主要因素,提出了口腔器械设备防交叉感染的设计要求,重点讲述了口腔器械设备涉及防交叉感染的标准要求,以及国际最新标准化进展。%This paper analyzed the main factors that cause cross-infection of oral clinical, and presented the design requirements of anti-cross-infection dental devices and equipments. It focused on the requirements of dental devices and equipments standards involved in anti-cross-infection, as wel as the latest international standardization progress.

  14. Anti-cross-infection Design and Standard Requirements of Dental Devices and Equipments%口腔器械设备防交叉感染设计与标准要求

    Institute of Scientific and Technical Information of China (English)

    李丹荣

    2013-01-01

    This paper analyzed the main factors that cause cross-infection of oral clinical, and presented the design requirements of anti-cross-infection dental devices and equipments. It focused on the requirements of dental devices and equipments standards involved in anti-cross-infection, as wel as the latest international standardization progress.%  本文分析了引起口腔临床交叉感染的主要因素,提出了口腔器械设备防交叉感染的设计要求,重点讲述了口腔器械设备涉及防交叉感染的标准要求,以及国际最新标准化进展。

  15. 制冷空调设备绿色设计的技术和实践探讨%Technical and Practical Discussions on Green Design of Refrigeration and Air Conditioning Equipments

    Institute of Scientific and Technical Information of China (English)

    朱斌祥; 张缓缓; 曲本连; 彭飞; 李韶强

    2015-01-01

    空调行业作为能源消耗和环境污染的重要源流,对于节能环保承担着重要责任。制冷空调设备绿色设计的应用研究日益受到人们的重视。本文指出了制冷空调产品进行绿色设计的必要性,分析了制冷空调绿色设计中的主要因素及主要内容,对于目前制冷空调产品提出了相应的绿色设计方法,还提出了绿色设计在制冷空调产品中的应用策略,以及绿色产品的评价指标。%As an important part of energy consumption and environment pollution, the air conditioning industry takes a great responsibility for energy saving and environment protection. More and more attentions have been paid on the application investigation in the green design of refrigeration and air conditioning equipments. In the paper the necessity to conduct the green design of refrigeration and air conditioning equipments is pointed out. A series of major factors and technologies are analyzed. The green design methods are proposed for the practical refrigeration and air conditioning equipment. In addition, the application strategy of green design in the air conditioning and refrigeration field is presented and the evaluation indicators on green products are concluded.

  16. Modelling of diffraction grating based optical filters for fluorescence detection of biomolecules.

    Science.gov (United States)

    Kovačič, M; Krč, J; Lipovšek, B; Topič, M

    2014-07-01

    The detection of biomolecules based on fluorescence measurements is a powerful diagnostic tool for the acquisition of genetic, proteomic and cellular information. One key performance limiting factor remains the integrated optical filter, which is designed to reject strong excitation light while transmitting weak emission (fluorescent) light to the photodetector. Conventional filters have several disadvantages. For instance absorbing filters, like those made from amorphous silicon carbide, exhibit low rejection ratios, especially in the case of small Stokes' shift fluorophores (e.g. green fluorescent protein GFP with λ exc = 480 nm and λ em = 510 nm), whereas interference filters comprising many layers require complex fabrication. This paper describes an alternative solution based on dielectric diffraction gratings. These filters are not only highly efficient but require a smaller number of manufacturing steps. Using FEM-based optical modelling as a design optimization tool, three filtering concepts are explored: (i) a diffraction grating fabricated on the surface of an absorbing filter, (ii) a diffraction grating embedded in a host material with a low refractive index, and (iii) a combination of an embedded grating and an absorbing filter. Both concepts involving an embedded grating show high rejection ratios (over 100,000) for the case of GFP, but also high sensitivity to manufacturing errors and variations in the incident angle of the excitation light. Despite this, simulations show that a 60 times improvement in the rejection ratio relative to a conventional flat absorbing filter can be obtained using an optimized embedded diffraction grating fabricated on top of an absorbing filter. PMID:25071964

  17. OEE数据分析的设计与应用%Design and application of OEE data analysis in equipment management

    Institute of Scientific and Technical Information of China (English)

    梁岳

    2014-01-01

    基于在设备管理工作中应用设备综合效率(OEE)分析的目的,通过对OEE理论进行研究,并结合生产管控系统的实际情况,采用了将六大损失归类到时间开动率、性能开动率、合格品率三大指标中,再针对六大损失的末梢因素进行设备状态及其影响原因判别的方法,建立起OEE的数据模型;进一步结合QC工具的使用可以有效地对OEE数据进行分析,找到提高设备效率的思路与对策。%In the purpose of practicing Overall Equipment Effectiveness (OEE) in equipment management, the author builds up a model of OEE. First is classifying six losses by Time Utilization Ratio, Device Performance Ratio and Product Qualification Ratio. Second is identifying the equipment’s status including its cause by the end factors of the six losses. Also, by using QC tools to analysing OEE data can provide guidance for the maintenance operation.

  18. Mobile Equipment Expands Inventory.

    Science.gov (United States)

    McGough, Robert L.; And Others

    1978-01-01

    Describes the Mobile Equipment Modules (MEM) system in Duluth, Minnesota. MEM is a way to hold down costs and increase learning opportunities by consolidating purchases of expensive shop equipment within the school district, grouping the equipment in modules, and scheduling and moving it from school to school as needed. (MF)

  19. Detection of biomolecules and bioconjugates by monitoring rotated grating-coupled surface plasmon resonance

    CERN Document Server

    Szalai, Aniko; Somogyi, Aniko; Szenes, Andras; Banhelyi, Balazs; Csapo, Edit; Dekany, Imre; Csendes, Tibor; Csete, Maria

    2016-01-01

    Plasmonic biosensing chips were prepared by fabricating wavelength-scaled dielectric-metal interfacial gratings on thin polycarbonate films covered bimetal layers via two-beam interference laser lithography. Lysozyme (LYZ) biomolecules and gold nanoparticle (AuNP-LYZ) bioconjugates with 1:5 mass ratio were seeded onto the biochip surfaces. Surface plasmon resonance spectroscopy was performed before and after biomolecule seeding in a modified Kretschmann-arrangement by varying the azimuthal and polar angles to optimize the conditions for rotated grating-coupling. The shift of secondary and primary resonance peaks originating from rotated grating-coupling phenomenon was monitored to detect the biomolecule and bioconjugate adherence. Numerical calculations were performed to reproduce the measured reflectance spectra and the resonance peak shifts caused by different biocoverings. Comparison of measurements and calculations proved that monitoring the narrower secondary peaks under optimal rotated-grating coupling ...

  20. Radical Reactions in the Gas Phase: Recent Development and Application in Biomolecules

    Directory of Open Access Journals (Sweden)

    Yang Gao

    2014-01-01

    Full Text Available This review summarizes recent literature describing the use of gas phase radical reactions for structural characterization of complex biomolecules other than peptides. Specifically, chemical derivatization, in-source chemical reaction, and gas phase ion/ion reactions have been demonstrated as effective ways to generate radical precursor ions that yield structural informative fragments complementary to those from conventional collision-induced dissociation (CID. Radical driven dissociation has been applied to a variety of biomolecules including peptides, nucleic acids, carbohydrates, and phospholipids. The majority of the molecules discussed in this review see limited fragmentation from conventional CID, and the gas phase radical reactions open up completely new dissociation channels for these molecules and therefore yield high fidelity confirmation of the structures of the target molecules. Due to the extensively studied peptide fragmentation, this review focuses only on nonpeptide biomolecules such as nucleic acids, carbohydrates, and phospholipids.

  1. Electrical equipment qualification

    International Nuclear Information System (INIS)

    Electrical equipment qualification research programs being carried out by CEA, JAERI, and Sandia Laboratories are discussed. Objectives of the program are: (1) assessment of accident simulation methods for electrical equipment qualification testing; lower coarse (2) evaluation of equipment aging and accelerated aging methods; (3) determine radiation dose spectrum to electrical equipment and assess simulation methods for qualification; (4) identify inadequacies in electrical equipment qualification procedures and standards and potential failure modes; and (5) provide data for verifying and improving standards, rules and regulatory guides

  2. 聚醚醚酮精制工艺及设备的设计与运行%Design and operation for process and equipment of polyetheretherketone refining

    Institute of Scientific and Technical Information of China (English)

    王树江

    2012-01-01

    In the process of polyetheretherketone (PEEK) production, reaction products, raw materials, solvents and by - products are mixed together. In order to get the pure PEEK, the polymerization product must be refined. Due to the longer process flow and higher consumption of energy and water, the current process and equipment were improved based on experimental data. The dispersed equipment with single function was integrated together. Firstly, solvent diphenyl sulfone was removed by acetone extraction; then fluoride salts and other water soluble substances were removed through water washing; finally, the pure material was obtained after vacuum drum drying. The above three steps of refining process were performed in the same equipment. Using the improved equipment, the time of PEEK refining is 22 h, the moisture mass fraction of material after drying reaches 0. 02% , and the material powdering rate is only 2. 85%. The practice shows that the improved technology is featured by concentrated process and simple operation, which shortens the refining time by 31 h, reduces energy and water consumption, and greatly improves the production efficiency.%聚醚醚酮生产过程中,反应产物、原料、溶剂及副产物混合在一起,为了得到纯的聚醚醚酮需对其聚合产物进行精制.针对现行生产工艺流程较长、能耗及水耗较大的特点,依据实验数据,对现行工艺、设备进行改进.将分散的、单一功能设备综合在一起,先经丙酮浸取,除去溶剂二苯砜;再经水洗除去氟盐等水溶性物质;最后经过真空转筒干燥得到纯物料,上述3步精制过程在同一设备中实现.使用改进后设备进行生产,聚醚醚酮精制时间为22 h,并且干燥后物料含水质量分数达到0.02%,物料的粉化率也仅为2.85%.经实际生产证明,改进后工艺集中,操作简化,精制时间较原工艺缩短31 h,同时降低了能耗,节约超纯水用量,较大程度地提高了生产效率.

  3. Design of Dual Circuit Power Supply System Based on Medical Equipment%基于医疗设备的双回路供电系统设计

    Institute of Scientific and Technical Information of China (English)

    王燕妮; 张立军; 李传伟

    2015-01-01

    This paper proposes the specific hardware environment and software program by analyzing the use of PLC control system in completing automatic switching principle of double circuit power supply system,in accordance with the working requirements of the distribution system circuit switch and the demands of eliability of power supply system for medical equipment,improving the reliability of the system.%针对医疗设备供电系统的可靠性要求,根据配电系统线路切换的工作要求,分析了利用PLC控制系统完成双回路供电系统的自动切换工作原理,给出了具体的硬件环境和软件程序,增强了系统的可靠性.

  4. Induction of Biomolecules in Mature Leaves of Terminalia arjuna Due to Feeding of Antheraea mylitta Drury

    Directory of Open Access Journals (Sweden)

    G. Abraham

    2004-01-01

    Full Text Available Terminalia arjuna is an important food plant of the tasar silkworm, Antheraea mylitta Drury. In this study, we investigated the induction of biomolecules in mature leaves of these plants subjected to insect feeding. Increase in total tannin content, lipid peroxidation, and trypsin inhibitor activity have been observed in mature leaves damaged by the insects. The growth rate of Vth instar larvae of A. mylitta fed on previously damaged foliage reduced by 87.1%. Induction of biomolecules for defense mechanisms in relation to herbivore damage has been discussed.

  5. A new method for immobilization of biomolecules using preirradiation grafting at low temperature

    International Nuclear Information System (INIS)

    A new method of biomolecule immobilization is described in which a monomer-conjugated enzyme (asparaginase, Asp) is grafted together with free monomer (acrylamide, AAm) onto a cellulose sheet which had been preirradiated in a 60Co source. The preirradiation and grafting steps are carried out in air at - 780C and in vacuum at 00C respectively. The grafting is probably caused by trapped radicals. The immobilized enzyme retains significant activity and is stable to storage. The technique is applicable to immobilization of a wide variety of biomolecules, such as enzymes, antibodies and drugs. The products may be used for therapeutic or diagnostic applications. (author)

  6. Metal Stable Isotope Tagging: Renaissance of Radioimmunoassay for Multiplex and Absolute Quantification of Biomolecules.

    Science.gov (United States)

    Liu, Rui; Zhang, Shixi; Wei, Chao; Xing, Zhi; Zhang, Sichun; Zhang, Xinrong

    2016-05-17

    The unambiguous quantification of biomolecules is of great significance in fundamental biological research as well as practical clinical diagnosis. Due to the lack of a detectable moiety, the direct and highly sensitive quantification of biomolecules is often a "mission impossible". Consequently, tagging strategies to introduce detectable moieties for labeling target biomolecules were invented, which had a long and significant impact on studies of biomolecules in the past decades. For instance, immunoassays have been developed with radioisotope tagging by Yalow and Berson in the late 1950s. The later languishment of this technology can be almost exclusively ascribed to the use of radioactive isotopes, which led to the development of nonradioactive tagging strategy-based assays such as enzyme-linked immunosorbent assay, fluorescent immunoassay, and chemiluminescent and electrochemiluminescent immunoassay. Despite great success, these strategies suffered from drawbacks such as limited spectral window capacity for multiplex detection and inability to provide absolute quantification of biomolecules. After recalling the sequences of tagging strategies, an apparent question is why not use stable isotopes from the start? A reasonable explanation is the lack of reliable means for accurate and precise quantification of stable isotopes at that time. The situation has changed greatly at present, since several atomic mass spectrometric measures for metal stable isotopes have been developed. Among the newly developed techniques, inductively coupled plasma mass spectrometry is an ideal technique to determine metal stable isotope-tagged biomolecules, for its high sensitivity, wide dynamic linear range, and more importantly multiplex and absolute quantification ability. Since the first published report by our group, metal stable isotope tagging has become a revolutionary technique and gained great success in biomolecule quantification. An exciting research highlight in this area

  7. Addressing challenges in preparation of 211At-labeled biomolecules for use in targeted alpha therapy

    International Nuclear Information System (INIS)

    There are significant challenges in the development of 211At-labeled biomolecules for application to targeted alpha therapy. Challenges that we have addressed include development of: (1) labeling methods to obtain high in vivo 211At-label stability, (2) approaches to consistently obtain high recovery yields of Na[211At]At from irradiated bismuth targets, (3) methods to optimize biomolecule labeling yields, (4) reagents for use of 211At in pretargeting approach to cancer therapy, and (5) 211At-labeled antibodies in conditioning for hematopoietic cell transplantation. (author)

  8. The Design and Realization of Wireless Management System of Port Machinery Equipment%港口机械设备无线管理系统的设计与实现

    Institute of Scientific and Technical Information of China (English)

    李胜永; 张智华; 房世龙; 安天生

    2014-01-01

    On the basis of analyzing the characteristics of the port machinery equipment, the authors use the wireless transmission module NRF24L01 to achieve the wireless transmission of information in port e-quipment management, and also complete a node hardware circuit design, software configuration and low-power node implementation strategy. This plan has passed the simple test of wireless communication which provides an integration solution to port machinery equipment management in port construction of Internet of Things.%在分析港口机械设备特点的基础上,采用NRF24L01无线传输模块实现了港口设备管理信息的无线传输,并进行了节点硬件电路设计、软件配置及低功耗设计。该组建方案通过了无线通信的简单测试,为物联网港口建设中港口机械设备管理提供了一种有效方法。

  9. Non-conventional Indoor GIS Layout Design of 220kV Distribution Equipment in Guangzhou Xintang Power Plant%广州新塘电厂220 kV屋内GIS非常规布置的设计

    Institute of Scientific and Technical Information of China (English)

    唐柳燕

    2014-01-01

    ∶针对广州新塘电厂2×330MW机组工程厂区布置的特殊性及局限性,文章详细分析论述了220kV配电装置采用屋内GIS型式非常规布置的设计过程及其特点,提出合适的布置方案,解决了220kV配电装置占地及出线问题,为类似工程提供借鉴。%The design and the characteristics of the non-conventional indoor GIS layout of 220kV distribution equip-ment were discussed and analyzed in the paper based on the particularity and limitation of plant layout of Guangzhou Xintang power plant, and a reasonable layout was proposed which solves the land occupation and outgoing line prob-lems of the 220kV distribution equipment and can be well referenced by similar projects.

  10. The room of the X-rays equipment for Siti Aminah Hospital Bumi Ayu Central Java has been designed to achieve 125 kV and 200 mA capacity

    International Nuclear Information System (INIS)

    The room of the X-rays equipment for Siti Aminah Hospital Bumi Ayu Central Java has been designed to achieve 125 kV and 200 mA capacity, so as to provide radiation properly during operation. In order to achieve safe radiation exposure to the operator and patient, analysis and calculation are needed regarding time exposure, distance and shield width as required by radiation standard, procedure and principle. The result of calculation are expected to give exact maximum doses both for operator and patients. The shielding of the room, consist of concrete and Pb. (author)

  11. Renewal of radiological equipment.

    Science.gov (United States)

    2014-10-01

    In this century, medical imaging is at the heart of medical practice. Besides providing fast and accurate diagnosis, advances in radiology equipment offer new and previously non-existing options for treatment guidance with quite low morbidity, resulting in the improvement of health outcomes and quality of life for the patients. Although rapid technological development created new medical imaging modalities and methods, the same progress speed resulted in accelerated technical and functional obsolescence of the same medical imaging equipment, consequently creating a need for renewal. Older equipment has a high risk of failures and breakdowns, which might cause delays in diagnosis and treatment of the patient, and safety problems both for the patient and the medical staff. The European Society of Radiology is promoting the use of up-to-date equipment, especially in the context of the EuroSafe Imaging Campaign, as the use of up-to-date equipment will improve quality and safety in medical imaging. Every healthcare institution or authority should have a plan for medical imaging equipment upgrade or renewal. This plan should look forward a minimum of 5 years, with annual updates. Teaching points • Radiological equipment has a definite life cycle span, resulting in unavoidable breakdown and decrease or loss of image quality which renders equipment useless after a certain time period.• Equipment older than 10 years is no longer state-of-the art equipment and replacement is essential. Operating costs of older equipment will be high when compared with new equipment, and sometimes maintenance will be impossible if no spare parts are available.• Older equipment has a high risk of failure and breakdown, causing delays in diagnosis and treatment of the patient and safety problems both for the patient and the medical staff.• Every healthcare institution or authority should have a plan for medical imaging equipment upgrade or replacement. This plan should look forward a

  12. Design and Application of Electric Power Automation Equipment Online Monitoring System%调度自动化设备状态在线监测系统的设计与应用

    Institute of Scientific and Technical Information of China (English)

    刘晖

    2016-01-01

    The current electric power dispatching automation system of equipment maintenance management mainly limited to the configuration of equipment management. In the face of all kinds of unexpected events, there is not an effective early warning in time, so design and make application of dispatching automation equipment status online monitoring system. The system adopts the modular structure design, with real-time monitoring, alarm and remote maintenance, diagnosis, and other functions. After the system is applied in Anhui Chaohu Electric Power Supply Company, realized real-time monitoring and diagnosis of automation equipment operation condition. Alarm through a variety of alarm way in order to make the maintenance personnel process faults in time, effectively ensure the safe and stable and reliable operation of the dispatching automation equipment.%目前电力调度自动化系统对设备的维护管理主要局限于设备的配置管理,面对各种突发性事件不能进行及时、有效预警,为此设计并应用了调度自动化设备状态在线监测系统。该系统采用模块化结构设计,具有实时监测、告警及远程维护、诊断等功能。该系统在安徽省电力公司巢湖市供电公司应用后,实现了对自动化设备运行工况的实时监测和诊断,及时发现故障,并通过多种方式告警,使维护人员及时处理故障,有效保障了调度自动化设备的安全、稳定和可靠运行。

  13. Lifecycle Management of Safeguards Equipment

    International Nuclear Information System (INIS)

    In recent years, traditional procurement procedures for safeguards equipment have experienced major setbacks that have led to costly and time-consuming re-design and re-evaluation periods, as well as delays in the delivery and deployment of urgently needed equipment. A common element of all encountered problems is the rapid development of technical components. The accelerated pace of 69 safeguards systems development, when coupled with the absence of a disciplined lifecycle approach to design and development, leads to early technical obsolescence as well as the inability to support a safeguards system over its operational lifecycle. This condition is further aggravated by safeguards equipment suppliers who wrestle with economies of scale associated with a unique safeguards market that generally does not provide sufficient margins to stay in business. As a result, international agencies charged with safeguards responsibilities find it difficult to secure the supply of identical safeguards equipment over periods of ten or more years. However, all these problems are merely symptoms of the lack of an integrated lifecycle management approach with early involvement of all parties: vendors and their suppliers, national laboratories and contracted developers, national support programs, and international agencies with nonproliferation responsibilities. The following paper will describe the unique constellation of players within the safeguards community, and why this constellation is a cause of most of the problems inherent in traditional procurement procedures. Further, it will offer a comprehensive lifecycle management approach that will ensure the availability of identical safeguards equipment over its required lifespan (ten to fifteen years). It should be noted that an integrated lifecycle management approach will be difficult to implement and will require a fundamental re-orientation of efforts in: need identification, system design and development, funding, and

  14. SDH设备时钟中的数字锁相环设计%Design of Digital Phase Locked Loop Used in SDH Equipment Clock

    Institute of Scientific and Technical Information of China (English)

    伍文君; 黄芝平; 章明沛; 刘纯武

    2009-01-01

    A novel Digital Phase Locked Loop used in SDH equipment Clock is proposed. The phase detector of the DPLL is implemented with the time-to-digital converter whose resolution is 200 ps. With this improvement of the phase detector' s resolution, the DPLL shows excellent performance. The DPLL has stable frequency output, has excellent performance to track the reference timing, and can change the reference timing smoothly. It meets the requirement given in ITU-T Recommendation G. 813.%提出了一种新的用于实现SDH设备时钟的数字锁相环,采用时数转换器来实现数字锁相环中的鉴相器;该时数转换器的时间测量精度达到200 ps,因而极大地改进了鉴相器的鉴相精度;改进后的数字锁相环具有很好的频率稳定度和相位特性,对时钟源有很好的跟踪能力,且能实现时钟源的平滑切换.完全满足了ITU-TG.813规范要求.

  15. Microfluidic Devices for Manipulation and Detection of Beads and Biomolecules

    OpenAIRE

    Jönsson, Mats

    2006-01-01

    This thesis summarises work towards a Lab-on-Chip (LOC). The request for faster and more efficient chemical and biological analysis is the motivation behind the development of the LOC-concept. Microfluidic devices tend to become increasingly complex in order to include, e.g. sample delivery, manipulation, and detection, in one chip. The urge for smart and simple design of robust and low-cost microdevices is addressed and discussed. Design, fabrication and characterization of such microdevices...

  16. Electric utility engineer`s FGD manual -- Volume 2: Major mechanical equipment; FGD proposal evaluations; Use of FGDPRISM in FGD system modification, proposal, evaluation, and design; FGD system case study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-04

    Part 2 of this manual provides the electric utility engineer with detailed technical information on some of the major mechanical equipment used in the FGD system. The objectives of Part 2 are the following: to provide the electric utility engineer with information on equipment that may be unfamiliar to him, including ball mills, vacuum filters, and mist eliminators; and to identify the unique technique considerations imposed by an FGD system on more familiar electric utility equipment such as fans, gas dampers, piping, valves, and pumps. Part 3 provides an overview of the recommended procedures for evaluating proposals received from FGD system vendors. The objectives are to provide procedures for evaluating the technical aspects of proposals, and to provide procedures for determining the total costs of proposals considering both initial capital costs and annual operating and maintenance costs. The primary objective of Part 4 of this manual is to provide the utility engineer who has a special interest in the capabilities of FGDPRISM [Flue Gas Desulfurization PRocess Integration and Simulation Model] with more detailed discussions of its uses, requirements, and limitations. Part 5 is a case study in using this manual in the preparation of a purchase specification and in the evaluation of proposals received from vendors. The objectives are to demonstrate how the information contained in Parts 1 and 2 can be used to improve the technical content of an FGD system purchase specification; to demonstrate how the techniques presented in Part 3 can be used to evaluate proposals received in response to the purchase specification; and to illustrate how the FGDPRISM computer program can be used to establish design parameters for the specification and evaluate vendor designs.

  17. Optimum Design to Hydraulic Pressure System of New Type Pressure Modes of Special Heat Treatment Equipments%专用热处理设备新型施压模式的液压系统优化设计

    Institute of Scientific and Technical Information of China (English)

    张剑慈; 黄云峰; 谢慧萍

    2012-01-01

    一般的淬火设备都是施压与淬火共用一套液压系统,难以满足工作要求,为了保证提高液压淬火系统的工作可靠性,保证产品质量,对表面淬火专用热处理设备的液压系统进行了优化设计.阐述了优化设计后两套独立的液压系统的工作原理,二种施压模式.实践证明:采用该设备对带有中心孔的叶轮、齿轮及盘类零件进行表面淬火,其淬火性能良好.%The generic quenching equipment was usually using a same hydraulic pressure system when pressing and quenching. It was difficult to reach working requirement. In order to make sure to improve the working reliability of hydraulic pressure quenching system, and to assure the quality of the products, the hydraulic pressure system of Special Heat Treatment Equipments with Surface Quenching was designed in optimum. The operating principle and the two sets of pressure modes of the two hydraulic pressure system after optimum designed were expatiated. It has been proved by practice that by adopting this equipment, well performance has been provided with well performance when surface quenching to impellers, gears and disc parts with central holes.

  18. WP EMPLACEMENT CONTROL AND COMMUNICATION EQUIPMENT DESCRIPTIONS

    International Nuclear Information System (INIS)

    The objective and scope of this document are to list and briefly describe the major control and communication equipment necessary for waste package emplacement at the proposed nuclear waste repository at Yucca Mountain. Primary performance characteristics and some specialized design features of the required equipment are explained and summarized in the individual subsections of this document. This task was evaluated in accordance with QAP-2-0 and found not to be quality affecting. Therefore, this document was prepared in accordance with NAP-MG-012. The following control and communication equipment are addressed in this document: (1) Programmable Logic Controllers (PLC's); (2) Leaky Feeder Radio Frequency Communication Equipment; (3) Slotted Microwave guide Communication Equipment; (4) Vision Systems; (5) Radio Control Equipment; and (6) Enclosure Cooling Systems

  19. WP EMPLACEMENT CONTROL AND COMMUNICATION EQUIPMENT DESCRIPTIONS

    Energy Technology Data Exchange (ETDEWEB)

    N.T. Raczka

    1997-10-02

    The objective and scope of this document are to list and briefly describe the major control and communication equipment necessary for waste package emplacement at the proposed nuclear waste repository at Yucca Mountain. Primary performance characteristics and some specialized design features of the required equipment are explained and summarized in the individual subsections of this document. This task was evaluated in accordance with QAP-2-0 and found not to be quality affecting. Therefore, this document was prepared in accordance with NAP-MG-012. The following control and communication equipment are addressed in this document: (1) Programmable Logic Controllers (PLC's); (2) Leaky Feeder Radio Frequency Communication Equipment; (3) Slotted Microwave guide Communication Equipment; (4) Vision Systems; (5) Radio Control Equipment; and (6) Enclosure Cooling Systems.

  20. Cellular Viscosity in Prokaryotes and Thermal Stability of Low Molecular Weight Biomolecules.

    Science.gov (United States)

    Cuecas, Alba; Cruces, Jorge; Galisteo-López, Juan F; Peng, Xiaojun; Gonzalez, Juan M

    2016-08-23

    Some low molecular weight biomolecules, i.e., NAD(P)H, are unstable at high temperatures. The use of these biomolecules by thermophilic microorganisms has been scarcely analyzed. Herein, NADH stability has been studied at different temperatures and viscosities. NADH decay increased at increasing temperatures. At increasing viscosities, NADH decay rates decreased. Thus, maintaining relatively high cellular viscosity in cells could result in increased stability of low molecular weight biomolecules (i.e., NADH) at high temperatures, unlike what was previously deduced from studies in diluted water solutions. Cellular viscosity was determined using a fluorescent molecular rotor in various prokaryotes covering the range from 10 to 100°C. Some mesophiles showed the capability of changing cellular viscosity depending on growth temperature. Thermophiles and extreme thermophiles presented a relatively high cellular viscosity, suggesting this strategy as a reasonable mechanism to thrive under these high temperatures. Results substantiate the capability of thermophiles and extreme thermophiles (growth range 50-80°C) to stabilize and use generally considered unstable, universal low molecular weight biomolecules. In addition, this study represents a first report, to our knowledge, on cellular viscosity measurements in prokaryotes and it shows the dependency of prokaryotic cellular viscosity on species and growth temperature. PMID:27558730

  1. Nanohybrid structure analysis and biomolecule release behavior of polysaccharide-CDHA drug carriers

    Science.gov (United States)

    Huang, Li-Ying; Liu, Ting-Yu; Liu, Tse-Ying; Mevold, Andreas; Hardiansyah, Andri; Liao, Hung-Chou; Lin, Chin-Ching; Yang, Ming-Chien

    2013-10-01

    Nanoscaled polymer composites were prepared from polysaccharide chitosan (CS) and Ca-deficient hydroxyapatite (CDHA). CS-CDHA nanocomposites were synthesized by in situ precipitation at pH 9, and the CS-CDHA carriers were then fabricated by ionic cross-linking methods using tripolyphosphate and chemical cross-linking methods by glutaraldehyde and genipin. Certain biomolecules such as vitamin B12, cytochrome c, and bovine serum albumin were loaded into the CS-CDHA carriers, and their release behaviors were investigated. Furthermore, these CS-CDHA carriers were examined by transmission electron microscopy, electron spectroscopy for chemical analysis, and X-ray diffraction. The release behavior of the biomolecules was controlled by the CS/CDHA ratios and cross-linked agents. By increasing the concentration of CS and the concentration of the cross-linking agents, cross-linking within carriers increases, and the release rate of the biomolecules is decreased. Moreover, the release rate of the biomolecules from the CS-CDHA carriers at pH 4 was higher than that at pH 10, displaying a pH-sensitive behavior. Therefore, these CS-CDHA hydrogel beads may be useful for intelligent drug release and accelerate bone reconstruction.

  2. Biomolecule Analogues 2-Hydroxypyridine and 2-Pyridone Base Pairing on Ice Nanoparticles

    Czech Academy of Sciences Publication Activity Database

    Rubovič, Peter; Pysanenko, Andriy; Lengyel, Jozef; Nachtigallová, Dana; Fárník, Michal

    (2016). ISSN 1089-5639 R&D Projects: GA ČR GA14-14082S Institutional support: RVO:61388955 Keywords : ice nanoparticles * hydrogen bonding * biomolecules Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 2.693, year: 2014

  3. Extraction of Biomolecules Using Phosphonium-Based Ionic Liquids + K3PO4 Aqueous Biphasic Systems

    Directory of Open Access Journals (Sweden)

    Cláudia L. S. Louros

    2010-04-01

    Full Text Available Aqueous biphasic systems (ABS provide an alternative and efficient approach for the extraction, recovery and purification of biomolecules through their partitioning between two liquid aqueous phases. In this work, the ability of hydrophilic phosphonium-based ionic liquids (ILs to form ABS with aqueous K3PO4 solutions was evaluated for the first time. Ternary phase diagrams, and respective tie-lines and tie-lines length, formed by distinct phosphonium-based ILs, water, and K3PO4 at 298 K, were measured and are reported. The studied phosphonium-based ILs have shown to be more effective in promoting ABS compared to the imidazolium-based counterparts with similar anions. Moreover, the extractive capability of such systems was assessed for distinct biomolecules (including amino acids, food colourants and alkaloids. Densities and viscosities of both aqueous phases, at the mass fraction compositions used for the biomolecules extraction, were also determined. The evaluated IL-based ABS have been shown to be prospective extraction media, particularly for hydrophobic biomolecules, with several advantages over conventional polymer-inorganic salt ABS.

  4. Recovery of biomolecules from marinated herring (Clupea harengus) brine using ultrafiltration through ceramic membranes

    DEFF Research Database (Denmark)

    Gringer, Nina; Hosseini, Seyed Vali; Svendsen, Tore; Undeland, Ingrid; Christensen, Morten Lykkegaard; Baron, Caroline P.

    2015-01-01

    recovery of high value biomolecules such as proteins, fatty acids, minerals, and phenolic compounds. Chemical and biological oxygen demand (COD, BOD5) as well as total suspended solids (TSS) were also measured to follow the performance of the ultrafiltration. The retentates contained 75-82% (95% TSS and...

  5. Immobilization of biomolecules onto surfaces according to ultraviolet light diffraction patterns

    DEFF Research Database (Denmark)

    Petersen, Steffen B.; Gennaro, Ane Kold Di; Neves Petersen, Teresa;

    2010-01-01

    We developed a method for immobilization of biomolecules onto thiol functionalized surfaces according to UV diffraction patterns. UV light-assisted molecular immobilization proceeds through the formation of free, reactive thiol groups that can bind covalently to thiol reactive surfaces. We demons...

  6. Design and Implementation of Basic Data Mining System of Secondary Equipment%二次设备基础数据挖掘系统的设计与实现

    Institute of Scientific and Technical Information of China (English)

    林志超

    2016-01-01

    给出面向二次系统辅助决策的供电局二次设备基础数据挖掘系统的技术框架,并从惠州供电局二次设备数据管理的现状及需求出发,设计数据挖掘系统的主要功能模块,主要的数据分析功能包括基础统计及关联规则、聚类分析等数据挖掘方法。最后介绍系统实现。%Presents the technical framework of the secondary equipment data mining system of Power Supply Bureau, which is designed for the deci-sion support of the secondary system in power grid. The main system functional modules are designed based on the analysis of the current situation and requirement of secondary equipment data management in Huizhou Power Supply Bureau. Main data analysis methods in-clude basic statistics, association rules, clustering analysis and other data mining methods. Finally, the implementation of the system is in-troduced.

  7. Implementation of an ex situ stabilization technique at the Sand Springs superfund site to solidify and stabilize acid tar sludges involving a quick-lime based stabilization process and innovative equipment design

    Energy Technology Data Exchange (ETDEWEB)

    McManus, R.W. [SOUND Environmental Services, Inc., Dallas, TX (United States); Grajczak, P. [ARCO, Los Angeles, CA (United States); Wilcoxson, J.C. [ARCO, Plano, TX (United States); Webster, S.D. [Environmental Protection Agency, Dallas, TX (United States)

    1997-12-31

    An old refinery site was safely remediated a year before schedule and for 25% less than final engineering estimates for the stabilization remedy thanks to energetic project management and innovative design involving ex situ stabilization/solidification of acid tar sludges. A quicklime based process, Dispersion by Chemical Reaction (DCR{trademark}), was employed to solidify and stabilize (SS) over 103,000 cubic meters (135,000 cubic yards) of petroleum waste, mostly acidic tarry sludge. The SS process was selected over competing methods because it afforded minimal volume increase, could readily achieve Record of Decision (ROD) specified physical and chemical treatment goals, could be implemented with treatment equipment that minimized emissions, and could be performed with low reagent usage and at low cost. To ensure treatment goals were achieved and an accelerated schedule met, a custom designed and fabricated transportable treatment unit (TTU) was employed to implement the process. The treated material was visually soil-like in character, it was left in stockpiles for periods of time, and it was placed and compacted in the on site landfill using standard earth-moving equipment.

  8. Minimum Weight Design of a Leaf Spring Tapered in Thickness and Width for the Hubble Space Telescope-Space Support Equipment

    Science.gov (United States)

    Rodriguez, P. I.

    1990-01-01

    A linear elastic solution to the problem of minimum weight design of cantilever beams with variable width and depth is presented. The solution shown is for the specific application of the Hubble Space Telescope maintenance mission hardware. During these maintenance missions, delicate instruments must be isolated from the potentially damaging vibration environment of the space shuttle cargo bay during the ascent and descent phases. The leaf springs are designed to maintain the isolation system natural frequency at a level where load transmission to the instruments in a minimum. Nonlinear programming is used for the optimization process. The weight of the beams is the objective function with the deflection and allowable bending stress as the constraint equations. The design variables are the width and depth of the beams at both the free and the fixed ends.

  9. ITER tokamak buildings and equipment layout

    International Nuclear Information System (INIS)

    The International Thermonuclear Experimental Reactor (ITER) design has evolved to a level of maturity that has enabled the building designers to define the major dimensions and characteristics of the cluster of buildings that contain the tokamak and adjacent support equipment. Three-dimensional building models developed in a CATIA database provide the framework for the equipment layout. This article describes the preliminary layout of all major pieces of equipment, large bore pipes, ducts, busbars and other services. It is anticipated that some features of the layout will change as equipment design is advanced and future decisions are made, but these changes are not expected to alter the basic building design and any necessary changes are facilitated by the 3-D CATIA models. 1 ref., 6 figs

  10. 40 CFR 63.1003 - Equipment identification.

    Science.gov (United States)

    2010-07-01

    ... connectors in a designated area or length of pipe subject to the provisions of this subpart are identified as... pressure relief devices equipped with rupture disks, under the provisions of § 63.1011(e) of this...

  11. 40 CFR 65.103 - Equipment identification.

    Science.gov (United States)

    2010-07-01

    ... individually identified if all connectors in a designated area or length of pipe subject to the provisions of... relief devices equipped with rupture disks under the provisions of § 65.111(e). (5)...

  12. Radiological services and imaging equipment management

    International Nuclear Information System (INIS)

    Implementation of a long range capital asset management program in radiological and imaging equipment should be designed to enhance imaging quality, maximise up-time, ensure throughput, reduce cost and ensure patient and operator safety is discussed

  13. 小型真空双锅油炸设备控制系统的设计%Designing the Control System of the Small Double-Cauldron Vacuum Frying Equipment

    Institute of Scientific and Technical Information of China (English)

    夏德昭; 刘铎; 向立志

    2001-01-01

    提出了以单片机为核心、PC机作监控的小型真空双锅油炸设备控制系统,详细介绍了软硬件的具体设计过程。新型芯片和典型抗干扰措施的使用提高了控制的性能,增强了系统的稳定性。%Using the single chip processor as the center and a IBM-PC computer as the monitor, we design this control system of the small double-cauldron vacuum frying equipment. The process of software and hardware designing is described in this paper in detail. The application of the new elements and the typical measures of resisting interference improves the control performance and enhances the reliability of control system.

  14. Data communication equipment

    International Nuclear Information System (INIS)

    The contents of this book are introduction of data communication on definition, purpose and history, information terminal about data communication system and data transmission system, data transmit equipment of summary, transmission cable, data port, concentrator and front-end processor, audio communication equipment like phones, radio communication equipment of summary on foundation of electromagnetic waves, AM transmitter, AM receiver, FM receiver and FM transmitter, a satellite and mobile communication equipment such as earth station, TT and C and Cellular phone, video telephone and new media apparatus.

  15. Design and analysis of sodium carbonate recycling drying equipment for cyclohexanone production%环己酮生产中碳酸钠回收干燥装置的设计与分析

    Institute of Scientific and Technical Information of China (English)

    黎树根

    2012-01-01

    A new type of drying equipment was designed according to the characteristics of the recycling and utilization of waste sodium carbonate as the by-product of alkali waste burning in cyclohexanone process. The drying process, structure and working principle of the drying equipment were analyzed and calculated. The results showed that the automatic recycling drying equipment for sodium carbonate was consist of drying box, heating air system, dehumidifying system, scattering system and packaging system. The drying curves of sodium carbonate drying equipment were obtained through the drying experiment using a temperature-control electric oven. The drying capacity of this system reached 1 -2 t/h and the moisture content of sodium carbonate was below 2% after drying. The system saved the drying cost without environment pollution by using process gas waste as the heat re-souce. This equipment had the advantages of high drying capacity, high thermal efficiency, low energy consumption and good regulation performance, which successfully resolved the problem of alkali waste treatment in cyclohexanone industry.%针对环己酮生产过程中废碱碳酸钠回收利用的工艺特点,设计了一种新型干燥装置,对干燥器的干燥流程、干燥器的结构和工作原理进行了分析及计算.结果表明:循环自动干燥碳酸钠设备主要由干燥箱、供热风系统、抽湿系统、扩散系统和包装系统组成;通过温控由电烘箱进行碳酸钠干燥实验,得到了碳酸钠干燥设备的干燥曲线,该系统干燥能力达1 ~2 t/h,干燥后碳酸钠含水率小于2%;该系统利用工厂废烟气作热源,节省干燥成本,且无环境污染.该设备干燥能力大,热效率高,能耗低,调控性能好,很好的解决了环己酮工业中废碱处理的难题.

  16. 考虑不确定性的保障设备设计方案决策方法%A Decision-making Method about Design Proposal of Support Equipment Taking Uncertainty into Account

    Institute of Scientific and Technical Information of China (English)

    李华府

    2011-01-01

    The author researched into the influence of fuzziness on the optimum decision-making process of support equipment design proposal,proposed a comprehensive decision-making method based on fuzzy mathematics theory and grey correlation analysis. Taking uncertainty into account,and established a mathematical model. This model determines the relative superior grey correlation degress of every tradeoff design proposal through calculation of fuzzy grey correlation coefficients of every support equipment tradeoff design scheme, and sequences the tradeoff design proposals according to the good and the bad in accordance with grey correlation degree for realizing decision-making.%研究了模糊性对装备的保障设备设计方案优选决策过程中的影响,基于模糊数学理论和灰色关联分析提出了一个考虑不确定性的综合决策方法,并建立了数学模型.该模型通过计算各保障设备的备选设计方案到正、负理想设计方案的模糊灰色关联系数,来确定各备选方案的相对优势灰色关联度,依据相对灰色关联度对各备选方案进行优劣排序,实现决策.通过某型机载装备的外场测试设备方案的立项竞标决策案例,对模型进行了应用.

  17. 某型雷达自动测试设备的设计%Design of Automatic Test Equipment for Certain Guidance Radar

    Institute of Scientific and Technical Information of China (English)

    马艳

    2012-01-01

    捷变频雷达具有频率快速跳变、不易被捕获而受到干扰的特点,以往对捷变频雷达的测试采用静态分析方法,不能反映雷达真实的工作状态;文章基于PXI总线构建新型捷变频雷达测试设备,通过研制一种能覆盖捷变频雷达的频率范围并自动跳频的信号源,实现了测试设备跟随雷达频率自动跳频进行雷达的自动测试,能真实反映雷达的工作状态;实验结果表明,系统检测与控制精度高,具有一定的实用性.%Frequency agility radar is a kind of guidance radar system, which has the characteristics of quick frequency agility and difficult being captured and disturbed. The traditional test of frequency agility radar is performed by static analysis method. It cannot give the true operation state of radar. A new test equipment is proposed in this paper based on PXI bus. By the simulator of signal source developed, which can cover the frequency coverage of frequency agility radar and hop frequency automatically, the radar can be automatic agility frequency tested by simulator following radar frequency. Based on the new simulator, the true operation of radar is given. The experimental results show that the automatic test system has high accuracy. The technology and methods adopted in the system are practical.

  18. Improvement of the obtention process of 131 I of ININ through studies of equipment design and process parameters fitting in the simulator

    International Nuclear Information System (INIS)

    The main objective of the work was to achieve a high yield of the reaction that happens among the vapors of 131 I and the NaOH to obtain sodium iodide (Na131 I) in solution optimizing the contact time of the molecules in gaseous state of 131 I with the NaOH molecules through the bubbling velocity of the 131 I in the solution of NaOH 0.1 N, as well as the operation temperature during the distillation process by dry via starting from tellurium dioxide (TeO2) with the purpose of that the 131 I that is obtained in the form of Na131 I solution presents the necessary quality that allows to distribute it in the market. The particular objectives were: a) To improve the distillation equipment used for the obtaining of 131 I starting from irradiated tellurium dioxide redrawing the dilution system with the purpose of recovering the 131 I in a minimum volume of sodium hydroxide (NaOH). b) To achieve a bigger time of contact among the molecules of 131 I in gaseous state with the molecules of NaOH in solution through the bubbling velocity and of the redrawing of the dilution system. c) To implement the production of 131 I by dry distillation via starting from tellurium dioxide, obtaining it with a high radionuclide and radiochemical purity. d) To obtain 131 I with the necessary specifications that it marks the pharmacopoeia and it can be used with medical ends. (Author)

  19. Division of Scientific Equipment - Overview

    International Nuclear Information System (INIS)

    Full text: The Scientific Equipment Division consists of the Design Group and the Mechanical Workshop. The activity of the Division includes the following: * designs of devices and equipment for experiments in physics; their mechanical construction and assembly. In particular, these are vacuum chambers and installations for HV and UHV;* maintenance and upgrading of the existing installations and equipment in our Institute; * participation of our engineers and technicians in design works, equipment assembly and maintenance for experiments in foreign laboratories. The Design Group is equipped with PC-computers and AutoCAD graphic software (release 2000 and Mechanical Desktop 4.0) and an A0 plotter, which allow us to make drawings and 2- and 3-dimensional mechanical documentation to the world standards. The Mechanical Workshop offers a wide range of machining and treatment methods with satisfactory tolerances and surface quality. They include: * turning - cylindrical elements of a length up to 2000 mm and a diameter up to 400 mm, and also disc type elements of a diameter up to 600 mm and a length not exceeding 300 mm, * milling - elements of length up to 1000 mm and gear wheels of diameter up to 300 mm, * grinding - flat surfaces of dimensions up to 300 mm x 1000 mm and cylindrical elements of a diameter up to 200 mm and a length up to 800 mm, * drilling - holes of a diameter up to 50 mm, * welding - electrical and gas welding, including TIG vacuum-tight welding, * soft and hard soldering, * mechanical works including precision engineering, * plastics treatment - machining and polishing using diamond milling, modelling, lamination of various shapes and materials, including plexiglas, scintillators and light-guides, * painting - paint spraying with possibility of using furnace-fired drier of internal dimensions of 800 mm x 800 mm x 800 mm. Our workshop is equipped with the CNC milling machine which can be used for machining of work pieces up to 500 kg. The machine

  20. Remote handling equipment for SNS

    International Nuclear Information System (INIS)

    This report gives information on the areas of the SNS, facility which become highly radioactive preventing hands-on maintenance. Levels of activity are sufficiently high in the Target Station Area of the SNS, especially under fault conditions, to warrant reactor technology to be used in the design of the water, drainage and ventilation systems. These problems, together with the type of remote handling equipment required in the SNS, are discussed

  1. The application of a self-design electric leakage detector in detecting laparoscopic equipment%一种自设计漏电检测仪在杆状腔镜器械漏电检测中的应用

    Institute of Scientific and Technical Information of China (English)

    胡玉琴; 刘红松; 黄天翊; 陈肖敏

    2016-01-01

    目的:设计一种检测腔镜杆状器械漏电的装置,以有效解决因腔镜器械漏电造成的脏器副损伤问题。方法:在专利技术的基础上设计漏电检测仪,实现杆状腔镜手术器械漏电检测与漏电点精确检测,并对2013-2015年期间医院手术腔镜器械进行检测验证。结果:应用漏电检测仪检测6500余件腔镜器械,检测出1138件绝缘层破裂漏电器械,检出率为17.5%,有效降低了腔镜手术器械漏电原因造成的脏器副损伤的发生。结论:新型杆状腔镜器械漏电检测仪具有有效性和实用性,为手术以及器械安全管理与维护提供了检测器具,具有技术推广价值,可为建立腔镜器械使用追溯系统、实现腔镜器械闭环管理打下基础。%Objective:To design a device for detecting laparoscopic equipment electric leakage is to prevent the secondary viscera injury from electric leakage of laparoscopic equipment. Methods: On the basis of patent technology, the new detector was designed to detect the electric leakage of laparoscopic instrument accurately for leakage detection and leakage point of rod-shaped endoscopic devices. And surgical endoscopic equipments were tested by the new detector in the hospital between 2013 and 2015.Results: We tested over 6500 pieces of laparoscopic instruments by the electric leakage detector and found 1138 pieces of laparoscopic instruments due to insulation cracking. The detection rate was 17.5%. This new device could reduce the electric leakage of surgical laparoscopic instruments to avoided secondary viscera injury significantly.Conclusion: It is effective and practical for operation and safety management and maintenance of surgical laparoscopic instruments. This device could set up the base for establishment of tracing system of endoscopic instrument to achieve closed-loop management of endoscopic equipment. It’s worth to being popularized.

  2. Design of Remote Monitoring and Diagnosis System of Conveying Equipments on Working Face Based on LabVIEW%基于LabVIEW的工作面输送设备远程监测与诊断系统设计

    Institute of Scientific and Technical Information of China (English)

    雷志鹏; 宋建成; 李艳伟; 崔晓慧

    2012-01-01

    In view of problem that current monitoring and diagnosis systems of conveying equipments on working face can be only used at underground field, a remote monitoring and diagnosis system of conveying equipments based on LabVIEW in surface dispatching center was designed. General structure of monitoring and diagnosis system of conveying equipments of whole mine manless working face composed of the system and underground monitoring and fault diagnosis system of conveying equipments based on PLC was given, implementation of data exchange between the system and the underground system was analyzed, and method of BP neural network fault identification in LabVIEW and design of SQL Server data management system were introduced. The actual application shows that the system runs stably and realizes real-time monitoring and diagnosis of conditions of scraper conveyor, transfer conveyor and crusher on working face in surface dispatching center.%针对现有工作面输送设备监测与诊断系统只能在井下现场使用的问题,设计了一种基于LabVIEW的安装于地面调度中心的输送设备远程监测与诊断系统;给出了由该系统与井下基于PLC的输送设备监测与诊断系统相结合构成的全矿井无人工作面输送设备监测与诊断系统的整体结构,分析了该系统与井下系统间的数据交换实现,介绍了在LabVIEW中运行BP神经网络故障识别的方法及SQL Server数据管理系统的设计.实际应用表明,该系统运行稳定,实现了在地面调度中心实时监测和综合诊断工作面刮板输送机、转载机和破碎机的工况.

  3. The Westinghouse equipment lifetime monitor

    International Nuclear Information System (INIS)

    The Westinghouse Equipment LIFETIME Monitor addresses a long-standing need in the nuclear industry-A way to continuously and passively monitor the temperature and radiation environment of components located throughout the plant. This compact device (approximately 2.5 x 2.3 x 1.3 inches) is capable of performing up to six different functions. Each function is designed to measure a different type or range of environmental parameter. Monitoring options include peak temperature, integrated temperature, low and high range gamma ray dose, beta particle dose, and neutron radiation. These various functions allow flexibility in selecting the precise environmental parameters to be monitored to meet plant specific requirements and budget constraints. The data acquired from the Equipment LIFETIME Monitor can be used in a variety of ways, including: - Extending the qualified life of safety-related equipment by improving on initial assumptions regarding service environment, - Conducting long term temperature and radiation surveys to ensure operation within qualified limits, - Assessing potential age-related degradation of major high cost components for purposes of plant life extension, and - Justifying continued use of equipment following an accidental excursion in environmental radiation or temperature. (author)

  4. Equipment maintenance and repair

    Directory of Open Access Journals (Sweden)

    Walia DS

    2010-10-01

    Full Text Available The repair and maintenance of ophthalmic equipment, including surgical instruments and diagnostic devices, can be compared to the maintenance of a motor vehicle, something many of us understand well.If you had a car, would you drive it until the fuel runs out or until a tyre punctures, and then abandon it to buy a new car? Of course not. However, many eye care units purchase (or receive as a donation expensive and delicate equipment which, because of poor maintenance, ends up breaking down. If there is not a system in place to report breakdowns and to plan or carry out repairs, equipment can remain unusable for long periods of time. Sometimes, this equipment ends up being dumped. Good maintenance habits and an effective repair system will minimise the amount of time equipment is unusable.

  5. 变速箱装配线设备管理信息系统设计与实现%Gearbox Assembly Line Equipment Management Information System Design and Implementation

    Institute of Scientific and Technical Information of China (English)

    贾亮; 王雅君; 王德权

    2014-01-01

    该文是通过对南昌某双离合器变速箱装配企业的管理制度和业务流程的分析和研究,设计了一套设备管理信息系统,该系统是以OPC、UDP远程通讯技术为基础,通过计算机和PLC的信息交互,实现了对变速箱装配线各个工位的设备工作状态进行实时监控,显示现场装配设备的故障报警信息、维护保养信息等。同时采集并存储装配过程中的重要数据,为后续的SPC、OEE分析提供了依据。该系统已在装配现场应用,并满足了生产要求。%This article is based on the Nanchang some double clutch transmission assembly enterprise management system and business process analysis and research, design a set of equipment management information system, this system is based on OPC, UDP remote communication technology, through the information interaction of computer and PLC, realized the transmission as-sembly line every station equipment working status real-time monitoring, display field assembly equipment malfunction alarm in-formation, maintenance, etc. Acquisition and store the important data in the assembly process at the same time , and provide the basis for the follow-up of SPC, OEE analysis. The system has been applied to assembly on site, and meet the production require-ments.

  6. Design of Repairable EMI/Moisture Sealing Techniques for Electronic Equipment%电子设备可维修电磁干扰/水汽密封技术设计

    Institute of Scientific and Technical Information of China (English)

    谢义水

    2011-01-01

    在实际环境下,由导电衬垫实现电磁屏蔽的电子设备,因电化学腐蚀频仍发生,因而环境适应性差,是亟待解决的工程技术难题。文中以材料腐蚀学和防护工程学为基础,应用既能实现水汽密封,又能对电磁泄漏发射能量起衰减作用的"密封屏蔽衬垫"实现电子设备可维修水汽密封与电磁屏蔽复合防护设计,满足了电子设备抗恶劣气候环境和电磁环境的防护性、可靠性、维修性、实装性和低成本等综合技战术要求。%In the realistic environment,the frequent occurrence of electrochemical corrosion in electronic equip-ment due to the use of conductive gaskets has led to the poor environmental adaptability,which is an urgent problem to solve.On the basis of the theory of the material corrosion and protection engineering,the application of seal-shield gasket in electronic equipment can seal moisture and reduce the emission energy of electromagnetic leakage.Thus the compound repairable protection design of moisture sealing and electromagnetic shielding can be achieved.And its advantages can meet the requirements of technology and tactics in adverse climate and electromagnetic environment such as protection,reliability,maintenance,economics,practicability etc.

  7. 太阳能干燥热带牧草设备设计研究%Solar Drying of Tropical Forage Equipment Design

    Institute of Scientific and Technical Information of China (English)

    王娟

    2014-01-01

    热带牧草的干燥品质关系着热带畜牧业的发展。由于海南岛太阳辐射强度大,因而设计了用于太阳能干燥热带牧草的平台,其主要由太阳能集热器、风机、干燥仓、风道和控制系统等组成。针对干燥平台设计优化了太阳能集热器,对其结构、吸热涂层材料、上下通道距离比值、串并联连接方式等对集热效率的影响进行实验研究,并设计一套自动跟踪太阳能集热器系统,最终确定优化的实验平台。太阳能干燥热带牧草成本低、环保、效率高,具有广阔的市场前景。%Tropical forage dry relation with tropical development of animal husbandry , Hainan island has strong solar ra-diation , design a solar drying tropical forage platform , the test platform consists of solar collectors , fans, dry warehouse , duct , control systems and other components .Design and optimization a drying platform for flat-plate solar collectors , do-ing experimental study on collector efficiency which impact by Its structure , absorbing coating material , the upper and lower channel distance ratio , series and parallel connections , etc.And to design a set of automatic tracking solar collector system ,ultimately determine the optimal test platform .Solar drying of tropical forages has low cost , green, high efficien-cy , and has broad market prospects .

  8. PROMSYS, Plant Equipment Maintenance and Inspection Scheduling

    International Nuclear Information System (INIS)

    1 - Description of problem or function: PROMSYS is a computer system designed to automate the scheduling of routine maintenance and inspection of plant equipment. This 'programmed maintenance' provides the detailed planning and accomplishment of lubrication, inspection, and similar repetitive maintenance activities which can be scheduled at specified predetermined intervals throughout the year. The equipment items included are the typical pumps, blowers, motors, compressors, automotive equipment, refrigeration units, filtering systems, machine shop equipment, cranes, elevators, motor-generator sets, and electrical switchgear found throughout industry, as well as cell ventilation, shielding, containment, and material handling equipment unique to nuclear research and development facilities. Four related programs are used to produce sorted schedule lists, delinquent work lists, and optional master lists. Five additional programs are used to create and maintain records of all scheduled and unscheduled maintenance history. 2 - Method of solution: Service specifications and frequency are established and stored. The computer program reviews schedules weekly and prints, on schedule cards, instructions for service that is due the following week. The basic output from the computer program comes in two forms: programmed-maintenance schedule cards and programmed-maintenance data sheets. The data sheets can be issued in numerical building, route, and location number sequence as equipment lists, grouped for work assigned to a particular foreman as the foreman's equipment list, or grouped by work charged to a particular work order as the work-order list. Data sheets grouped by equipment classification are called the equipment classification list

  9. 基于Zigbee的低压设备能耗与谐波监测节点设计%The Node Design of Energy Cost and Harmonic Monitoring for Low-Voltage Equipment based on Zigbee

    Institute of Scientific and Technical Information of China (English)

    吴迪迪; 窦文雷; 王海鳌

    2012-01-01

    为了对智能楼宇内用电设备所产生的功耗及谐波污染情况进行监测,进而为智能楼宇降低功耗、提高用电效率提供参数依据.设计了基于Zigbee无线网络的功耗与谐波监测节点。该节点由电力监测模块和Zigbee网络模块组成,二者分别实现信号的检测和传输功能,共同构成一个完整的监测节点。主要介绍Zigbee网络的构建和电力监测方法,设计基于三星$3C2410嵌入式处理器的谐波与功耗监测模块,论述Zigbee网络模块的软硬件设计并建立星型网络连接。经试验检测,设备可监控和累计用电设备的电能损耗及谐波污染情况,并通过Zigbee无线网络将数据发送至上位机。%In order to detect the power and harmonic pollution of the intelligent buildings, thereby reducing power consumption for smart buildings and improve the efficiency of electricity parameters in accordance with, the power consumption and harmonic monitoring node based on Zigbee wireless has been designed in this paper. The equipment include a power monitoring part and a Zigbee wireless network part which two complete power monitoring function together. This paper focuses on the Zigbec network and power monitoring methods; designed power monitoring module based on Samsung S3C2410 embedded processor; Zigbee terminal nodes, touters, and the coordination of hardware and software design are discussed in detail and establish a star network connection. Detected by the test, the device can monitor and accumulated electrical energy consumption, it can monitor and cumulative the energy loss and harmonic pollution which generated by the electrical equipment. The data will send to the host computer by Zigbee wireless network. The manner of equipment organization's network is simple and flexible, the device are easy to use and enable to complete the monitoring function.

  10. On the Need for Reliable Seismic Input Assessment for Optimized Design and Retrofit of Seismically Isolated Civil and Industrial Structures, Equipment, and Cultural Heritage

    Science.gov (United States)

    Martelli, Alessandro

    2011-01-01

    Based on the experience of recent violent earthquakes, the limits of the methods that are currently used for the definition of seismic hazard are becoming more and more evident to several seismic engineers. Considerable improvement is felt necessary not only for the seismic classification of the territory (for which the probabilistic seismic hazard assessment—PSHA—is generally adopted at present), but also for the evaluation of local amplification. With regard to the first item, among others, a better knowledge of fault extension and near-fault effects is judged essential. The aforesaid improvements are particularly important for the design of seismically isolated structures, which relies on displacement. Thus, such a design requires an accurate definition of the maximum value of displacement corresponding to the isolation period, and a reliable evaluation of the earthquake energy content at the low frequencies that are typical of the isolated structures, for the site and ground of interest. These evaluations shall include possible near-fault effects even in the vertical direction; for the construction of high-risk plants and components and retrofit of some cultural heritage, they shall be performed for earthquakes characterized by very long return periods. The design displacement shall not be underestimated, but neither be excessively overestimated, at least when using rubber bearings in the seismic isolation (SI) system. In fact, by decreasing transverse deformation of such SI systems below a certain value, their horizontal stiffness increases. Thus, should a structure (e.g. a civil defence centre, a masterpiece, etc.) protected in the aforesaid way be designed to withstand an unnecessarily too large earthquake, the behaviour of its SI system will be inadequate (i.e. it will be too stiff) during much more frequent events, which may really strike the structure during its life. Furthermore, since SI can be used only when the room available to the structure

  11. Unique safety valve design using a floating magnetic coupler and metal-to-metal sealing capability reduces pressure equipment requirements and increases safety valve integrity in ultra deepwater applications

    Energy Technology Data Exchange (ETDEWEB)

    Vinzant, Mike; Vick, James [Halliburton Energy Services, Inc. (United States); Parakka, Anthony [Dexter Magnetic Technology, Inc., Elk Grove Village, IL (United States)

    2004-07-01

    Simplified design concepts, increased use of non-elastomeric and metal-to-metal (M-t-M) sealing materials, and enhanced validation testing have drastically improved tubing-retrievable safety valve (TRSV) performance over the last decade. However, the demands imposed by deep-water, high-pressure/high-temperature (HP/HT) environments, high-flow-rate gas reservoirs and remote subsea applications have also increased, and in spite of continuing improvement in safety-valve technology, equipment has continued to be pushed to its limits. This paper reviews the challenges in achieving 100% M-t-M sealing capability within a TRSV. In addition, this paper will review a unique TRSV design that is a revolutionary new concept. This design incorporates a floating magnetic coupler that allows the hydraulic actuator to be positioned in a dedicated chamber isolated from contact with well fluids and pressure. Since the hydraulic actuator has been separated from the tubing wellbore, this new valve is the first in the industry to have 100% M-t-M sealing with no moving seals within the tubing wellbore. The magnetic-coupler concept particularly benefits deep and ultra deep completions as the TRSV is set deeper, and thus, requires additional operating pressure. By using the magnetic coupler design, the operating pressure required for the TRSV is drastically reduced by removing any interaction between the hydraulic operating piston and the internal tubing-wellbore pressure. This is significantly beneficial for deep water systems where a lower operating pressure simplifies the overall operating system. This is important both for safety and costs since the use of the magnetic coupler design in subsea systems could eliminate the need for high-pressure equipment and the associated high-pressure umbilicals, far outweighing the cost of the TRSV. Some of the benefits of this new intrinsically simple design include: 1. Increases environmental and personnel safety; 2. Reduces system costs; 3

  12. Design Experience of the Lining-baking Equipment for New 260 t Mixing Bogie with Torpedo Retort%新型260 t鱼雷罐混铁车内衬烘烤装置的设计经验

    Institute of Scientific and Technical Information of China (English)

    杨薇萍

    2000-01-01

    在上海宝钢集团一钢公司2500m3高炉工程混铁车内衬烘烤装置的设计中,采用了高架金属软管供给煤气、稳焰烧嘴和计算机按预设工况进行自动烘烤的新技术,成功地将转炉煤气用于混铁车内衬烘烤作业。通过一年多的生产实践,充分显示了该装置具有结构简单、操作维护方便、安全可靠和烘烤效果好等优点。%The new techniques of overhead metallic hose for gas supply, steady-flame burner and computer-based automatic baking are atopted in the design of the lining-baking equipment of the mixing bogie for the 2500m3 blast furnace project at the First Steel Co. of Shanghai Baosteel Group Corp. ,and the gas from converter is successfully used for baking the bogie lining. Over more then one year production practice,it is shown that the equipment has simple structure,convenient operation and maintenance, reliable safety and good baking effectiveness.

  13. Distribution Design for Kitchen Garbage Treatment Equipment of Wudang District in Guiyang%贵阳市乌当区厨余垃圾处理设备的分布设计

    Institute of Scientific and Technical Information of China (English)

    何春银; 王德盛; 吴晗; 廖玉梅

    2012-01-01

    随着城市化步伐的加快,生活垃圾量在不断地增加,传统的填埋方式不再适应社会的发展,今后的生活垃圾应进行科学的处理,变废为宝,再创价值。通过建立平面直角坐标系确定乌当区各镇的位置,且假设乌当区的厨余垃圾以镇为中心进行收集和运输,运用最小二乘法和MATLAB软件,求出设备的量和安置的最佳坐标。%As the pace of urbanization speed up, life garbage in continuing to rise, the traditional way of landfill no longer adapt society's development, henceforth life refuse shall be scientific processing, make it reutilized and create value. This paper explores the Guiyang city Wudang district kitchen garbage treat- ment equipment distribution design. We determine the position of each town by establishing the plane right angle coordinate system. If we presume to collect and transport on the center of the city, we can find out the number of equipment and the placement of the best coordinates according to the least Square method and MATLAB software.

  14. Effect of biomolecules adsorption on oxide layers developed on metallic materials used in cooling water systems

    International Nuclear Information System (INIS)

    This thesis was carried out in the frame of the BIOCOR ITN European project, in collaboration with the industrial partner RSE S.p.A. (Italy). Metallic materials commonly used in cooling systems of power plants may be affected by bio-corrosion induced by biofilm formation. The objective of this work was to study the influence of biomolecules adsorption, which is the initial stage of biofilm formation, on the electrochemical behaviour and the surface chemical composition of three metallic materials (70Cu-30Ni alloy, 304L stainless steel and titanium) in seawater environments. In a first step, the interactions between a model protein, the bovine serum albumin (BSA), and the surface of these materials were investigated. Secondly, tightly bound (TB) and loosely bound (LB) extracellular polymeric substances (EPS), that play a fundamental role in the different stages of biofilm formation, maturation and maintenance, were extracted from Pseudomonas NCIMB 2021 marine strain, and their effects on oxide layers were also evaluated. For that purpose, electrochemical measurements (corrosion potential E(corr) vs time, polarization curves and electrochemical impedance spectroscopy (EIS)) performed during the very first steps of oxide layers formation (1 h immersion time) were combined to surface analysis by X-ray photoelectron spectroscopy (XPS) and time-of-flight secondary ions mass spectrometry (ToF-SIMS). Compared to 70Cu-30Ni alloy in static artificial seawater (ASW) without biomolecules, for which a thick duplex oxide layer (outer redeposited Cu2O layer and inner oxidized nickel layer) is shown, the presence of BSA, TB EPS and LB EPS leads to a mixed oxide layer (oxidized copper and nickel) with a lower thickness. In the biomolecules-containing solutions, this oxide layer is covered by an adsorbed organic layer, mainly composed of proteins. A model is proposed to analyse impedance data obtained at E(corr). The results show a slow-down of the anodic reaction in the presence of

  15. 面向移动终端设备的学习APP的设计研究%Research on the Design of Learning APP for Mobile Terminal Equipment

    Institute of Scientific and Technical Information of China (English)

    范博; 于本成

    2015-01-01

    Birth of the Internet and mobile terminals mounted on mobile learning learning learning APP into a new trend, mobile learning can learn anytime, anywhere, on-demand occurs and also life-long learning, self-study and informal learning is an impor-tant one study, to further promote the rapid development of learning APP. Through the good experience of mobile learning and inter-active perspective, understand and analyze the current status of mobile learning systems development, trends and advantages, and disadvantages of, elaborate design and based on needs analysis and basic principles of the possible model designed to discuss the content, intended departure from the user needs to optimize learning APP is designed to improve the current shortcomings of the study of APP, it is part of the construction of a simple model to try, for research reference.%互联网与移动终端催生的移动学习搭载在学习APP上成为新兴学习潮流,移动学习可以使学习随时、随地、随需的发生,并且也是终身学习、自主学习与非正式学习的一种重要的学习方式之一,进一步促进了学习APP的迅猛发展.文章通过从移动学习的良好体验度和交互性的视角,了解分析了当前移动学习系统发展的现状、发展趋势和优势,以及存在的不足,详细阐述设计理念并依据需求分析和基本原则提出可能的模型设计来论述内容,旨在从用户需求出发优化学习APP的设计,以期改进目前学习APP的不足之处,是属于简单的模型建构尝试,仅供研究参考.

  16. 全自动单晶炉控制系统方案设计%Automatic Crystal Growth Equipment Control System Design

    Institute of Scientific and Technical Information of China (English)

    王庆; 张婷曼

    2011-01-01

    This design approach: using of general-purpose programmable logic controller(PLC),controlling and signal processing core by Beckhoff intelligent terminals,forming large-size touch screen friendly interface.carefully selecting advanced CCD measurement components and auxiliary surface temperature,etc.,completed of communication and control system through industrial field bus and Ethernet.%利用通用可编程控制器(PLC)、结合倍福(Beckhoff)智能端子作为控制和信号处理核心,以大尺寸触摸屏构成友好的人机界面。选用先进CCD测量元件及辅助液面测温等,通过工业现场总线加以太网完成整个系统的通讯及控制。

  17. 程控步进衰减器在通信测试设备上的设计应用%Design and Application of Programmable Step Attenuator in Communication Test Equipments

    Institute of Scientific and Technical Information of China (English)

    赵李华; 李渊

    2014-01-01

    Signal program-controlled attenuator regulation and level control function can be widely used in communications test equipment. Now, a new wideband programmable step attenuator, designed by monolithic integrated attenuator with MMIC HMC472LP4E, has advantages of larger dynamic attenuation range and excellent attenuation accuracy and so on.%程控衰减器的信号调节和电平控制功能可广泛应用于通信测试设备中,而利用HMC472LP4E单片集成衰减器设计的一款宽带程控步进衰减器,更具有较大的动态衰减范围、优良的衰减精度等优点。

  18. Industrial electrical plant test equipment

    Energy Technology Data Exchange (ETDEWEB)

    Armanini, D.

    1991-06-01

    This paper surveys the principle types of less than 1,000 volt ac - 1,500 volt dc industrial/commercial electrical plant test equipment, currently marketed in Italy, and used by electrical system installers to test system conformity with CEI (Italian Electrotechnical Committee) norms. These test involve: the verification of conductor integrity, electrical insolation resistance measurements, automatic circuit breaking efficiency checking, etc. Outlines are given of the instruments' main design, operation and performance features. The various types of advanced and multi-use devices include - insolation and ground resistance gauges, failure ring resistance or impedance gauges, differential device testing equipment, leakage current and circuit resistance gauges, sequence scopes, and, finally, digital thermocouple temperature gauges.

  19. Equipment selection for atmospheric drying

    International Nuclear Information System (INIS)

    Heavy water management is a major factor in deciding the economics of the PHWRs. Hence it is necessary to have an efficient recovery system, for the heavy water vapour escaping from various process systems and maintain a dry atmosphere in the recovery areas. While the basic objective of the atmospheric drying system is to maximize recovery and to minimize stack losses, it is equally important to optimally design the system with due consideration to operational and maintenance aspects. At present, heavy water vapour recovery in the existing Nuclear Power Plants (NPPs) is carried out by dryers of dual fixed bed design. While moving bed design could have some advantages, this has not been adopted so far because of the cumbersome mechanical design involved and special requirements for nuclear application. Developmental work done in this direction has resulted in compact alternative designs. In one of the designs, the change over from adsorption to regeneration is achieved by rotating the bed slowly. This concept is further refined in another alternative using a dessicant wheel. This paper contains brief equipment description of different designs; enumerates the design requirements of an atmospheric drying system for reactor building; describes steps for designing fixed bed type D2O vapour recovery system, and highlights advances in dryer technology. (author)

  20. 煤矿设备信息管理系统的构件化设计方法%Component Design Method of Information Management System of Mine Equipment

    Institute of Scientific and Technical Information of China (English)

    王维

    2012-01-01

    针对现有的煤矿设备信息管理系统开发效率和复用粒度低、难以满足煤矿个性需求的问题,从软件复用的角度介绍了一种煤矿设备信息管理系统的构件化设计方法,给出了系统开发模型和体系结构,详细介绍了系统构件的设计和实现方法.该构件化设计方法通过创建.NET功能构件,复用.NET中的基本构件和已创建的功能构件,最后在.NET开发平台上组装构件来达到软件复用的目的,提高了系统软件的开发效率、可靠性和可重用性.%In order to solve problems of low developing efficiency and reusing granularity of existing information management system of coal equipment which cannot meet personalized demands of coal mine, the paper introduced a component design method of information management system of coal equipment in term of software reuse, gave developing model and structure of the system, and introduced design and implementation of system component in details. The method achieves the purpose of software reuse by creating . NET functional components, reusing basic .NET components and the functional components and assembling the components on .NET development platform. The method improves developing efficiency, reliability and reusability of system software.

  1. Requirements for industrial x-ray equipment

    International Nuclear Information System (INIS)

    This safety code is concerned with the protection of all individuals who may be exposed to radiation emitted by X-ray equipment operating at energies up to 1 MeV as used in industrial radiography. This code presents basic radiation safety information for the protection of personnel operating and servicing X-ray equipment and other workers and the general public in the vicinity of areas where X-ray equipment is in operation. It specifies general safety features of design, construction and functioning of X-ray equipment and facilities; describes the responsibilities of the user, operator and maintenance personnel; contains recommendations to ensure that the X-ray equipment is used and maintained in accordance with the ALARA principle; and describes a program of personnel monitoring and radiation safety surveys. ( 6 refs., 5 tabs., 4 figs.)

  2. Real-time monitoring and manipulation of single bio-molecules in free solution

    Energy Technology Data Exchange (ETDEWEB)

    Li, Hung-Wing

    2005-08-01

    The observation and manipulation of single biomolecules allow their dynamic behaviors to be studied to provide insight into molecular genetics, biochip assembly, biosensor design, DNA biophysics. In a PDMS/glass microchannel, a nonuniform electroosmotic flow (EOF) was created. By using a scanning confocal fluorescence microscope and total internal-reflection fluorescence microscope (TIRFM), we demonstrated that negatively charged DNA molecules were focused by the nonuniform EOF into a thin layer at the glass surface. This phenomenon was applied to selectively detect target DNA molecules without requiring the separation of excessive probes and can be applied continuously to achieve high throughput. A variable-angle-TIRFM was constructed for imaging single DNA molecule dynamics at a solid/liquid interface. Implications we have are that the measured intensities cannot be used directly to determine the distances of molecules from the surface and the experimental counting results depict the distance-dependent dynamics of molecules near the surface; Molecules at low ionic strengths experience electrostatic repulsion at distances much further away from the surface than the calculated thickness of the electrical double layer. {delta}-DNA was employed as a nanoprobe for different functionalized surfaces to elucidate adsorption in chromatography. The 12-base unpaired ends of this DNA provide exposed purine and pyrimidine groups for adsorption. Patterns of self-assembled monolayers (SAMs) and patterns of metal oxides are generated. By recording the real-time dynamic motion of DNA molecules at the SAMs/aqueous interface, the various parameters governing the retention of an analyte during chromatographic separation can be studied. Even subtle differences among adsorptive forces can be revealed. Dynamic conformational changes of the prosthetic group, flavin adenine dinucleotide (FAD), in flavoprotein NADH peroxidase, in thioredoxin reductase, and in free solution were monitored

  3. The Patentability of Biomolecules – Does Online Bioinformatics Compromise Novelty?

    Directory of Open Access Journals (Sweden)

    Anton Hutter

    2006-04-01

    Full Text Available Researchers are becoming increasingly concerned that the confidentiality of their novel biomolecule sequences is being jeopardised, particularly when these sequences are either submitted to sequence databases or uploaded as query terms onto internet-based bioinformatic software suites. The researcher’s fears stem from the fact that the actual uploading of their sequences acts as a novelty destroying prior disclosure or publication, and that this may subsequently preclude valid patent protection for the sequences. This article addresses the key issues involved in the analyses of biomolecules, highlighting potential risks taken by many researchers in regard to patent protection and suggests possible ways in which these risks may be mitigated.

  4. Immobilization of biomolecules onto surfaces according to ultraviolet light diffraction patterns

    Energy Technology Data Exchange (ETDEWEB)

    Bjoern Petersen, Steffen; Kold di Gennaro, Ane; Neves-Petersen, Maria Teresa; Skovsen, Esben; Parracino, Antonietta

    2010-10-01

    We developed a method for immobilization of biomolecules onto thiol functionalized surfaces according to UV diffraction patterns. UV light-assisted molecular immobilization proceeds through the formation of free, reactive thiol groups that can bind covalently to thiol reactive surfaces. We demonstrate that, by shaping the pattern of the UV light used to induce molecular immobilization, one can control the pattern of immobilized molecules onto the surface. Using a single-aperture spatial mask, combined with the Fourier transforming property of a focusing lens, we show that submicrometer (0.7 {mu}m) resolved patterns of immobilized prostate-specific antigen biomolecules can be created. If a dual-aperture spatial mask is used, the results differ from the expected Fourier transform pattern of the mask. It appears as a superposition of two diffraction patterns produced by the two apertures, with a fine structured interference pattern superimposed.

  5. Antioxidants from defatted Indian Mustard (Brassica Juncea) protect biomolecules against in vitro oxidation.

    Science.gov (United States)

    Dua, Anita; Chander, Subhash; Agrawal, Sharad; Mahajan, Ritu

    2014-10-01

    Indian mustard seeds were defatted by distillation with hexane and the residue extracted with methanol was analyzed for potential antioxidants; ascorbate, riboflavin, and polyphenols. Gallic acid (129.796 μg), caffeic acid (753.455 μg), quercetin (478.352 μg) and kaempferol (48.060 μg)/g dry seeds were identified by HPLC analysis of the extract. DPPH free radical scavenging activity and protection of lipids, proteins and DNA against metal induced oxidation was examined. Defatted mustard seed remnant had excellent free radical scavenging activity and protects biomolecules with IC50 value 2.0-2.25 mg dry seed weight. Significant content of polyphenols in methanol extract of defatted seeds accounts for high antioxidant potential. We are the first to report the detailed analysis of antioxidant composition and protection of biomolecules against oxidative damage by methanol extract of mustard seed remnant after oil extraction. PMID:25320478

  6. Medical Issues: Equipment

    Science.gov (United States)

    ... strollers also have trays to carry medical equipment. Bath Chairs Specialized bath chairs provide comfortable and secure bathing for children and small adults with special needs. Bath chairs are adjustable, with multiple seat and back angles. ...

  7. Equipment for hydraulic testing

    International Nuclear Information System (INIS)

    Hydraulic testing in boreholes is one major task of the hydrogeological program in the Stripa Project. A new testing equipment for this purpose was constructed. It consists of a downhole part and a surface part. The downhole part consists of two packers enclosing two test-sections when inflated; one between the packers and one between the bottom packer and the bottom of the borehole. A probe for downhole electronics is also included in the downhole equipment together with electrical cable and nylon tubing. In order to perform shut-in and pulse tests with high accuracy a surface controlled downhole valve was constructed. The surface equipment consists of the data acquisition system, transducer amplifier and surface gauges. In the report detailed descriptions of each component in the whole testing equipment are given. (Auth.)

  8. Electronic equipment packaging technology

    CERN Document Server

    Ginsberg, Gerald L

    1992-01-01

    The last twenty years have seen major advances in the electronics industry. Perhaps the most significant aspect of these advances has been the significant role that electronic equipment plays in almost all product markets. Even though electronic equipment is used in a broad base of applications, many future applications have yet to be conceived. This versatility of electron­ ics has been brought about primarily by the significant advances that have been made in integrated circuit technology. The electronic product user is rarely aware of the integrated circuits within the equipment. However, the user is often very aware of the size, weight, mod­ ularity, maintainability, aesthetics, and human interface features of the product. In fact, these are aspects of the products that often are instrumental in deter­ mining its success or failure in the marketplace. Optimizing these and other product features is the primary role of Electronic Equipment Packaging Technology. As the electronics industry continues to pr...

  9. 发酵设备课程设计教学中抄袭现象的研究%Course Design of Plagiarism Phenomenon in Fermentation Engineering and Equipment

    Institute of Scientific and Technical Information of China (English)

    张超; 陈文兵; 武道吉; 侯书国; 郑晓吉

    2015-01-01

    As an important link of practice teaching, the fermentation engineering and equipment course design can play the connecting role between the preceding and the following in the practice teaching, and lay a good foundation for the students to work in the factory after graduation. There exist all different plagiarism phenomenon during the course design. The article shall exchange and discuss the teaching links, such as the status, opinion, contents and way of the course design.%发酵设备课程设计是重要的实践教学环节,在实践教学中起到衔接作用,可为学生进入工作岗位打下良好基础。但在课程设计教学过程中,学生之间存在不同程度的抄袭现象,对课程设计中抄袭现象产生的原因、解决方法和效果等各环节进行交流与探讨。

  10. Design and testing of head-stem segregation equipment for garlic%大蒜果秧分离试验装置的设计与测试

    Institute of Scientific and Technical Information of China (English)

    于昭洋; 胡志超; 王海鸥; 彭宝良; 谢焕雄; 吴峰

    2013-01-01

    Garlic is one of the major cash crops in China. Production, acreage, and exports of garlic in China are the highest in the world. As a seasonal operation, garlic harvesting in China is still mainly manual work, having the problems of low efficiency, high labor intensity, and huge occupation of farming season, which has constrained the further development of the garlic industry. The current domestic garlic harvesters are basically simple segmented machinery. The techniques of garlic combine harvesting is still in its infancy. Picking is the core technology on garlic combine harvesting, but it has not been refined well. In order to enhance operational performance of picking, a new kind of garlic picking testbed was designed to carry out the studies on optimization design on structural and working parameters of a garlic-picking device. Lower damage and less stem are the two primary objectives in garlic harvesting. The garlic picking testbed consists of a clamping delivery device, a ranking/alignment device, a cutter, and an electric control system, which carry out garlic clamping, transport, ranking, alignment, and cutting at one time. The clamping delivery device of which core components are front track and middle track uses two tooth-shaped chains. Through the guidance of the two tracks, the trajectory and clamping style of the chains is changed, achieveing the transition from double chain clamping to chain-board-hairbrush clamping, The core components of the ranking/alignment devices are guidance rods, a ranking disk, finger, an alignment chain, and a hairbrush. In the test, the garlic was artificially fed. First, garlic plants are gripped by the clamping delivery device and transported backward. Under the interaction of ranking/alignment devices and clamping/delivery devices, garlic plants are ranked automatically and garlic bulbs are aligned automatically. After the garlic bulbs are aligned, garlic stems are cut by disc cutters to achieve garlic bulbs whose stems

  11. Nanohybrid structure analysis and biomolecule release behavior of polysaccharide-CDHA drug carriers

    OpenAIRE

    Huang, Li-Ying; Liu, Ting-Yu; Liu, Tse-Ying; Mevold, Andreas; Hardiansyah, Andri; Liao, Hung-Chou; Lin, Chin-Ching; Yang, Ming-Chien

    2013-01-01

    Nanoscaled polymer composites were prepared from polysaccharide chitosan (CS) and Ca-deficient hydroxyapatite (CDHA). CS-CDHA nanocomposites were synthesized by in situ precipitation at pH 9, and the CS-CDHA carriers were then fabricated by ionic cross-linking methods using tripolyphosphate and chemical cross-linking methods by glutaraldehyde and genipin. Certain biomolecules such as vitamin B12, cytochrome c, and bovine serum albumin were loaded into the CS-CDHA carriers, and their release b...

  12. Nanocoating for biomolecule delivery using layer-by-layer self-assembly

    OpenAIRE

    KEENEY, M; Jiang, X. Y.; Yamane, M.; Lee, M.; Goodman, S.; Yang, F.

    2015-01-01

    Since its introduction in the early 1990s, layer-by-layer (LbL) self-assembly of films has been widely used in the fields of nanoelectronics, optics, sensors, surface coatings, and controlled drug delivery. The growth of this industry is propelled by the ease of film manufacture, low cost, mild assembly conditions, precise control of coating thickness, and versatility of coating materials. Despite the wealth of research on LbL for biomolecule delivery, clinical translation has been limited an...

  13. Nanoscale surface properties and interaction with fundamental biomolecules of chlorite and phlogopite

    OpenAIRE

    Moro, Daniele

    2014-01-01

    The surface properties of minerals have important implications in geology, environment, industry and biotechnology and for certain aspects in the research on the origin of life. This research project aims to widen the knowledge on the nanoscale surface properties of chlorite and phlogopite by means of advanced methodologies, and also to investigate the interaction of fundamental biomolecules, such as nucleotides, RNA, DNA and amino acid glycine with the surface of the selected phyllosilica...

  14. Development of radioactively labelled cancer seeking biomolecules for targeted radiotherapy. Uruguay

    International Nuclear Information System (INIS)

    The main objective of this project is the labelling and quality control of biomolecules with radionuclides beta emitters with high purity and stability. Techniques and methodology for labelling with 188Re, 153Sm, and 125I as well as quality controls were done according to the recommendations of the first research coordination meeting of this CRP. Also some useful chelators reported in the literature were synthesized in our laboratory)

  15. NV Center Electron Paramagnetic Resonance of a Single Nanodiamond Attached to an Individual Biomolecule

    OpenAIRE

    Teeling-Smith, Richelle M.; Jung, Young Woo; Scozzaro, Nicolas; Cardellino, Jeremy; Rampersaud, Isaac; North, Justin A.; Šimon, Marek; Bhallamudi, Vidya P.; Rampersaud, Arfaan; Johnston-Halperin, Ezekiel; Poirier, Michael G.; Hammel, P. Chris

    2015-01-01

    A key limitation of electron paramagnetic resonance (EPR), an established and powerful tool for studying atomic-scale biomolecular structure and dynamics is its poor sensitivity, samples containing in excess of 10^12 labeled biomolecules are required in typical experiments. In contrast, single molecule measurements provide improved insights into heterogeneous behaviors that can be masked by ensemble measurements and are often essential for illuminating the molecular mechanisms behind the func...

  16. FUNCTIONALIZATION OF CARBON NANOTUBES BY DIFFERENT BIOMOLECULES FOR STABLE DISPERSION IN WATER

    OpenAIRE

    O. M. Burlaka; Ya. V. Pirko; Kolomys, O. F.; P. S. Smertenko; V. O. Glazunova; Konstantinova, T. E.; A. I. Yemets; Ya. B. Blume

    2015-01-01

    To select the effective methods for functionalizing carbon nanotubes and to compare the ability of a number of biological molecules (plasmid DNA, ATP, mix of deoxyribonucleoside triphosphates, bovine serum albumin, compounds of vitreous humor extract and sodium humate) to interact non-covalently with carbon nanotubes and mediate their dispersion in an aqueous medium was the aim of the work. Properties of carbon nanotubes-biomolecules conjugates were characterized using ultraviolet...

  17. A newly built setup for small bio-molecule fragmentation study in Lanzhou

    International Nuclear Information System (INIS)

    A new setup for studying ion induced small bio-molecule fragmentation processes has been built in Lanzhou, China. A preliminary collision experiment between a 30 keV He2+ ion beam and gas phase adenine molecules was performed. Partial TOF spectra associated to well-defined scattered projectile final charge states, He+ or He0 were recorded. Coincidence spectra between fragments were also obtained.

  18. Imparting biomolecules to a metal-organic framework material by controlled DNA tetrahedron encapsulation

    OpenAIRE

    Yongmei Jia; Benmei Wei; Ruixue Duan; Ying Zhang; Boya Wang; Abdul Hakeem; Nannan Liu; Xiaowen Ou; Shaofang Xu; Zhifei Chen; Xiaoding Lou; Fan Xia

    2014-01-01

    Recently, the incorporation of biomolecules in Metal-organic frameworks (MOFs) attracts many attentions because of controlling the functions, properties and stability of trapped molecules. Although there are few reports on protein/MOFs composites and their applications, none of DNA/MOFs composite is reported, as far as we know. Here, we report a new composite material which is self-assembled from 3D DNA (guest) and pre-synthesized MOFs (host) by electrostatic interactions and hydrophilic inte...

  19. Synthesis of new pyrrole-containing biomolecules as building blocks for functionalized polypyrroles in nanobiotechnology

    International Nuclear Information System (INIS)

    New pyrroles were synthesized wherein biomolecules such as α-amino acids, peptides or carbohydrates are attached to position 1 or 3 via suitable linkers. These conjugates were copolymerized with pyrrole by chemical polymerisation alone giving corresponding copolymers or in the presence of magnetic iron oxid nanoparticles resulting in functionalized core-shell-nanoparticles. Such products are interesting for biosensing, imaging or separation of biomaterials. They were characterized by several methods such as TEM, HRTEM, FTIR and measuring of magnetization.

  20. Etymology of transition metal biomolecules as a learning aid in Biological Chemistry

    International Nuclear Information System (INIS)

    Numerous functional biomolecules are associated with metals, i.e. the metallobiomolecules; more specifically, some are dependent on transition metals required for several crucial biological roles. Nevertheless, their names can lead to ambiguous interpretations concerning the properties and performances of this group of biological molecules. Their etymology may be useful by providing a more perceptive insight into their features. However, etymology can lead to incongruous conclusions, requiring an especially careful approach to prevent errors. Examples illustrating these subjects shall be examined (author)