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Sample records for bioloiski vrtgo mea

  1. MEA 86 Compound data

    Data.gov (United States)

    U.S. Environmental Protection Agency — This data file contains the full raw parameter data for the 86 compounds tested in the developmental MEA assay, as well as Area Under the Curve (AUC) calculations...

  2. MEA vacuum system

    International Nuclear Information System (INIS)

    Stroo, R.; Schwebke, H.; Heine, E.

    1984-01-01

    This report describes construction and operation of the MEA vacuum system of NIKHEF (Netherlands). First, the klystron vacuum system, beam transport system, diode pump and a triode pump are described. Next, the isolation valve and the fast valves of the vacuum system are considered. Measuring instruments, vacuum system commands and messages of failures are treated in the last chapter. (G.J.P.)

  3. Integrated Manufacturing for Advanced MEAs

    Energy Technology Data Exchange (ETDEWEB)

    Emory S. De Castro; Yu-Min Tsou; Mark G. Roelofs; Olga Polevaya

    2007-03-30

    This program addressed a two-pronged goal for developing fuel cell components: lowering of precious metal content in membrane electrode assemblies (MEAs), thereby reducing the fuel cell cost, and creating MEAs that can operate at 120oC and 25% RH whereby the system efficiency and effectiveness is greatly improved. In completing this program, we have demonstrated a significant reduction in precious metal while at the same time increasing the power output (achieved 2005 goal of 0.6g/Kw). We have also identified a technology that allows for one step fabrication of MEAs and appears to be a feasible path toward achieving DOE’s 2010 targets for precious metal and power (approaches 0.2g/Kw). Our team partner Du Pont invented a new class of polymer electrolyte membrane that has sufficient stability and conductivity to demonstrate feasibility for operation at 120 oC and low relative humidity. Through the course of this project, the public has benefited greatly from numerous presentations and publications on the technical understanding necessary to achieve these goals.

  4. High performance MEAs. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-15

    The aim of the present project is through modeling, material and process development to obtain significantly better MEA performance and to attain the technology necessary to fabricate stable catalyst materials thereby providing a viable alternative to current industry standard. This project primarily focused on the development and characterization of novel catalyst materials for the use in high temperature (HT) and low temperature (LT) proton-exchange membrane fuel cells (PEMFC). New catalysts are needed in order to improve fuel cell performance and reduce the cost of fuel cell systems. Additional tasks were the development of new, durable sealing materials to be used in PEMFC as well as the computational modeling of heat and mass transfer processes, predominantly in LT PEMFC, in order to improve fundamental understanding of the multi-phase flow issues and liquid water management in fuel cells. An improved fundamental understanding of these processes will lead to improved fuel cell performance and hence will also result in a reduced catalyst loading to achieve the same performance. The consortium have obtained significant research results and progress for new catalyst materials and substrates with promising enhanced performance and fabrication of the materials using novel methods. However, the new materials and synthesis methods explored are still in the early research and development phase. The project has contributed to improved MEA performance using less precious metal and has been demonstrated for both LT-PEM, DMFC and HT-PEM applications. New novel approach and progress of the modelling activities has been extremely satisfactory with numerous conference and journal publications along with two potential inventions concerning the catalyst layer. (LN)

  5. Thermodynamic modeling of acidic gas solubility in aqueous solutions of MEA, MDEA and MEA-MDEA blends

    DEFF Research Database (Denmark)

    Vrachnos, Ath.; Kontogeorgis, Georgios; Voutsas, EC

    2006-01-01

    and extended in this study to the absorption of carbon dioxide into aqueous monoethanolamine (MEA) solutions and aqueous MDEA-MEA blends. The results of the model are compared with experimental data taken from the literature. Very satisfactory predictions of acidic gas vapor-liquid equilibrium over MDEA, MEA...

  6. Harmonisasi Strategi Bersaing Kontraktor Nasional Skala Besar dalam Menghadapi MEA

    OpenAIRE

    eddy Irsan; siddiq siregar

    2017-01-01

    Abstrak: Pada awal Januari 2016, Era Masyarakat Ekonomi Asean (MEA) sudah diberlakukan dan akan menyebabkan perubahan persaingan tingkat regional di ASEAN, hal ini akan berdampak kepada strategi bersaing yang di laksanakan oleh Kontraktor Nasional. Tujuan penulisan paper ini adalah  untuk mengetahui keselarasan strategi bersaing Kontraktor Nasional di era MEA berdasarkan Manajemen Inovasi, karakteristik keunikan sumberdaya, dan keunggulan kompetitif yang berpengaruh kepada strategy bersaing. ...

  7. New MEA Materials for Improved DMFC Performance, Durability and Cost

    Energy Technology Data Exchange (ETDEWEB)

    Fletcher, James H. [University of North Florida; Campbell, Joseph L. [University of North Florida; Cox, Philip [University of North Florida; Harrington, William J. [University of North Florida

    2013-09-16

    Abstract Project Title: New MEA Materials for Improved DMFC Performance, Durability and Cost The University of North Florida (UNF)--with project partners the University of Florida, Northeastern University, and Johnson Matthey--has recently completed the Department of Energy (DOE) project entitled “New MEA Materials for Improved DMFC Performance, Durability and Cost”. The primary objective of the project was to advance portable fuel cell MEA technology towards the commercial targets as laid out in the DOE R&D roadmap by developing a passive water recovery MEA (membrane electrode assembly). Developers at the University of North Florida identified water management components as an insurmountable barrier to achieving the required system size and weight necessary to achieve the energy density requirements of small portable power applications. UNF developed an innovative “passive water recovery” MEA for direct methanol fuel cells (DMFC) which provides a path to system simplification and optimization. The passive water recovery MEA incorporates a hydrophobic, porous, barrier layer within the cathode electrode, so that capillary pressure forces the water produced at the cathode through holes in the membrane and back to the anode. By directly transferring the water from the cathode to the anode, the balance of plant is very much simplified and the need for heavy, bulky water recovery components is eliminated. At the heart of the passive water recovery MEA is the UNF DM-1 membrane that utilizes a hydrocarbon structure to optimize performance in a DMFC system. The membrane has inherent performance advantages, such as a low methanol crossover (high overall efficiency), while maintaining a high proton conductivity (good electrochemical efficiency) when compared to perfluorinated sulfonic acid membranes such as Nafion. Critically, the membrane provides an extremely low electro-osmotic drag coefficient of approximately one water molecule per proton (versus the 2-3 for

  8. Final Report - MEA and Stack Durability for PEM Fuel Cells

    Energy Technology Data Exchange (ETDEWEB)

    Yandrasits, Michael A.

    2008-02-15

    Proton exchange membrane fuel cells are expected to change the landscape of power generation over the next ten years. For this to be realized one of the most significant challenges to be met for stationary systems is lifetime, where 40,000 hours of operation with less than 10% decay is desired. This project conducted fundamental studies on the durability of membrane electrode assemblies (MEAs) and fuel cell stack systems with the expectation that knowledge gained from this project will be applied toward the design and manufacture of MEAs and stack systems to meet DOE’s 2010 stationary fuel cell stack systems targets. The focus of this project was PEM fuel cell durability – understanding the issues that limit MEA and fuel cell system lifetime, developing mitigation strategies to address the lifetime issues and demonstration of the effectiveness of the mitigation strategies by system testing. To that end, several discoveries were made that contributed to the fundamental understanding of MEA degradation mechanisms. (1) The classically held belief that membrane degradation is solely due to end-group “unzipping” is incorrect; there are other functional groups present in the ionomer that are susceptible to chemical attack. (2) The rate of membrane degradation can be greatly slowed or possibly eliminated through the use of additives that scavenge peroxide or peroxyl radicals. (3) Characterization of GDL using dry gases is incorrect due to the fact that fuel cells operate utilizing humidified gases. The proper characterization method involves using wet gas streams and measuring capillary pressure as demonstrated in this project. (4) Not all Platinum on carbon catalysts are created equally – the major factor impacting catalyst durability is the type of carbon used as the support. (5) System operating conditions have a significant impact of lifetime – the lifetime was increased by an order of magnitude by changing the load profile while all other variables remain

  9. MEA progress report, no. 10; 1st half year 1976

    International Nuclear Information System (INIS)

    1976-01-01

    A survey is given of the progress on the construction of the 300MeV MEA Linac at IKO, Amsterdam. The progress report deals with the construction of the linac itself with auxiliary components as well as the testing of these components, the work at the different experimental stations: the 100MeV chemical station, the 100MeV physics station, the 300MeV electron scattering station, the pion facility and the 300MeV chemical station

  10. High Temperature PEM Fuel Cell Stacks with Advent TPS Meas

    Directory of Open Access Journals (Sweden)

    Neophytides Stylianos

    2017-01-01

    Full Text Available High power/high energy applications are expected to greatly benefit from high temperature Polymer Electrolyte Membrane Fuel Cells (PEMFCs. In this work, a combinatorial approach is presented, in which separately developed and evaluated MEAs, design and engineering are employed to result in reliable and effective stacks operating above 180°C and having the characteristics well matched to applications including auxiliary power, micro combined heat and power, and telecommunication satellites.

  11. Peran Kepemimpinan Visioner dalam Menghadapi Masyarakat Ekonomi Asean (MEA

    Directory of Open Access Journals (Sweden)

    ABDUL MUIN

    2017-03-01

    Full Text Available ASEAN Economic Community (AEC is the largest integration effort applied in developing countries in Southeast Asia. By the implementation of MEA, It will create a free market with the movement of goods, services, foreign investment, labor and freer movement which is covers approximately 590 million people. By the implementation of the free market, then the market will work without some distortion. A logical consequence of these condition is high competitiveness and challenge to be able to compete. Under these conditions, the ideal leader is needed to achieve the vision and mission of the nation and constantly competitive in the competition that will happen. This study will be analyze and assessed the benefits of visionary leadership to face MEA 2015. The type of visionary leadership is important because this leadership type is emphasized that a leader must develop social architecture and to encourage people to be able to cooperate and raced in creating their creativity. Thus, the visionary leadership is expected to be a solution for the leaders in this country to be able to stay ahead in the competition and could lead this nation into a production base not to be a market base.  Abstrak Masyarakat Ekonomi ASEAN (MEA merupakan upaya integrasi terbesar yang diterapkan di negara berkembang di kawasan Asia Tenggara. Dengan diterapkannya MEA, akan tercipta pasar bebas dengan pergerakan barang, jasa, investasi asing, tenaga kerja serta pergerakan yang menjadi lebih bebas yang meliputi sekitar 590 juta orang. Dengan diterapkannya pasar bebas tersebut, maka pasar akan bekerja tanpa adanya distorsi. Konsekuensi logis yang muncul adalah terciptanya daya saing dan tantangan yang tinggi untuk dapat berkompetisi. Dengan kondisi demikian, pemimpin yang ideal sangat dibutuhkan untuk dapat meraih visi misi bangsa dan tetap kompetitif dalam persaingan yang akan terjadi. Dalam penelitian ini akan dianalisa dan dikaji manfaat dari tipe kepemimpinan

  12. Harmonisasi Strategi Bersaing Kontraktor Nasional Skala Besar dalam Menghadapi MEA

    Directory of Open Access Journals (Sweden)

    eddy Irsan

    2017-09-01

    Full Text Available Abstrak: Pada awal Januari 2016, Era Masyarakat Ekonomi Asean (MEA sudah diberlakukan dan akan menyebabkan perubahan persaingan tingkat regional di ASEAN, hal ini akan berdampak kepada strategi bersaing yang di laksanakan oleh Kontraktor Nasional. Tujuan penulisan paper ini adalah  untuk mengetahui keselarasan strategi bersaing Kontraktor Nasional di era MEA berdasarkan Manajemen Inovasi, karakteristik keunikan sumberdaya, dan keunggulan kompetitif yang berpengaruh kepada strategy bersaing. Metode penelitian ini dilakukan dengan menggunakan konseptual kerangka model (conceptual framwork models dengan membandingkan studi literatur dan penelitian terdahulu dan menggunakan model diagram yang sudah teruji. Analisa SWOT di gunakan untuk evaluasi secara kuantitatif. Sampel penelitian di bagikan kepada 30 orang responden sebagai pengambil keputusan dari seluruh Kontraktor Nasional. Ditemukan bahwa keunikan sumber daya tergolong biasa saja dan ditemukan juga bahwa keunggulan kompetitive pada posisi inbetween zone atau memilki keunggulan kompetitive rendah. Sehingga tindakan strategi bersaing yang harus dilakukan adalah strategi kerja sama (cooperative strategy diantara para pelaku industri konstruksi di negara ASEAN.Keyword : Manajemen Inovasi, Keunikan Sumber Daya, Strategi Bersaing, Keunggulan kompetitif

  13. High Performance Fuel Cell and Electrolyzer Membrane Electrode Assemblies (MEAs) for Space Energy Storage Systems

    Science.gov (United States)

    Valdez, Thomas I.; Billings, Keith J.; Kisor, Adam; Bennett, William R.; Jakupca, Ian J.; Burke, Kenneth; Hoberecht, Mark A.

    2012-01-01

    Regenerative fuel cells provide a pathway to energy storage system development that are game changers for NASA missions. The fuel cell/ electrolysis MEA performance requirements 0.92 V/ 1.44 V at 200 mA/cm2 can be met. Fuel Cell MEAs have been incorporated into advanced NFT stacks. Electrolyzer stack development in progress. Fuel Cell MEA performance is a strong function of membrane selection, membrane selection will be driven by durability requirements. Electrolyzer MEA performance is catalysts driven, catalyst selection will be driven by durability requirements. Round Trip Efficiency, based on a cell performance, is approximately 65%.

  14. Effects of ionizing radiation and cysteamine (MEA) on activity of mouse spleen adenyl cyclase

    International Nuclear Information System (INIS)

    Soltysiak-Pawluczuk, D.; Bitny-Szlachto, S.

    1976-01-01

    In mice X-irradiated with doses of 200 R and 400 R, there was a substantial increase in spleen adenyl cyclase activity; there was similar activation by MEA. In mice given MEA before irradiation, an additive effect of radiation and the radioprotective drug was observed. On the other hand, a dose of 800 R given either alone or after pre-treatment with MEA failed to elicit any change in cyclase activity. The results indicate the importance of the adenyl cyclase system in the response of cells to irradiation and action of MEA. (author)

  15. Fulfilling environment related international commitments through implementation of multilateral environmental agreements (meas) in pakistan

    International Nuclear Information System (INIS)

    Hussain, A.; Gillani, Z.A

    2014-01-01

    Multilateral Environmental Agreements (MEAS) help addresses the environmental problem being faced by the international community as a whole. The ultimate goal of reaching MEAs is to realize sustainable development across the globe. According to World Bank (2006), Pakistan's economy loses Rs.365 billion annually to environmental hazards. A key mechanism available under international law for countries to work together on global environmental issues is through MEAs. Pakistan is signatory to several MEAs and has acceded to other non-legally binding instruments, such as Agenda-21, Rio Principles and Johannesburg Plan of Implementation aiming at sustainable development of natural resources. As a party to various Conventions and Protocols, Pakistan has participating in different Conferences of Parties (COPs), Meetings of Parties (MOPs), and international consultative and technical meetings regarding MEAs organized by the United Nations and other international forum. Pakistan has been actively participating in and keeping liaison with institutional elements of each of these MEAs, i.e. COPs, the secretariat, advisory bodies, subsidiary bodies, clearing-house mechanisms, for effective decision making regarding the overall implementation and development of programme of work and strategic plans, budget and the revision of annexes to the treaties. Priorities and objectives of MEAs vary significantly from one international instrument to another while the common aspects include the sustainable development and use of natural resources and the protection of the environment in such a way as to ensure its judicious use. Based on different stages of implementation of these MEAs, the spectrum in priorities of Pakistan has quite broad. Pakistan attaches greater emphasis to crosscutting themes for MEAs that are primarily of a functional nature, such as strengthening of the capacities to meet the country's obligations or responsibilities under these agreements; enhancing coordination

  16. Adaptive Process Controls and Ultrasonics for High Temperature PEM MEA Manufacture

    Energy Technology Data Exchange (ETDEWEB)

    Walczyk, Daniel F. [Rensselaer Polytechnic Inst., Troy, NY (United States)

    2015-08-26

    The purpose of this 5-year DOE-sponsored project was to address major process bottlenecks associated with fuel cell manufacturing. New technologies were developed to significantly reduce pressing cycle time for high temperature PEM membrane electrode assembly (MEA) through the use of novel, robust ultrasonic (U/S) bonding processes along with low temperature (<100°C) PEM MEAs. In addition, greater manufacturing uniformity and performance was achieved through (a) an investigation into the causes of excessive variation in ultrasonically and thermally bonded MEAs using more diagnostics applied during the entire fabrication and cell build process, and (b) development of rapid, yet simple quality control measurement techniques for use by industry.

  17. Black boxes on wheels: research challenges and ethical problems in MEA-based robotics

    DEFF Research Database (Denmark)

    Bentzen, Martin Mose

    2016-01-01

    Robotic systems consisting of a neuron culture grown on a multielectrode array (MEA) which is connected to a virtual or mechanical robot have been studied for approximately 15 years. It is hoped that these MEA-based robots will be able to address the problem that robots based on conventional...... and that they are not likely to be solved within the field. After that, I discuss whether MEA-based robotics should be considered pop science. Finally, I investigate the ethical aspects of this research....

  18. Detailed H2 and CO Electrochemistry for a MEA Model Fueled by Syngas

    KAUST Repository

    Lee, W. Y.; Ong, K. M.; Ghoniem, A. F.

    2015-01-01

    © The Electrochemical Society. SOFCs can directly oxidize CO in addition to H2, which allows them to be coupled to a gasifier. Many membrane-electrode-assembly (MEA) models neglect CO electrochemistry due to sluggish kinetics and the water

  19. Electrochemical Separation, Pumping, and Storage of Hydrogen or Oxygen into Nanocapillaries Via High Pressure MEA Seals

    Science.gov (United States)

    2015-10-13

    412TW-PA-15560 Electrochemical Separation, Pumping, and Storage of Hydrogen or Oxygen into Nanocapillaries Via High Pressure MEA Seals...TITLE AND SUBTITLE Electrochemical Separation, Pumping, and Storage of Hydrogen or Oxygen into Nanocapillaries Via High Pressure MEA Seals...density storage of gases remains a major technological hurdle for many fields. The U.S. Department of Energy (DOE), for example, reduced their hydrogen

  20. MEA and DEE as additives on diesel engine using waste plastic oil diesel blends

    Directory of Open Access Journals (Sweden)

    Pappula Bridjesh

    2018-05-01

    Full Text Available Waste plastic oil (WPO is a standout amongst the most promising alternative fuels for diesel in view of most of its properties similar to diesel. The challenges of waste management and increasing fuel crisis can be addressed while with the production of fuel from plastic wastes. This experimental investigation is an endeavour to supplant diesel at least by 50% with waste plastic oil alongside 2-methoxy ethyl acetate (MEA and diethyl ether (DEE as additives. Test fuels considered in this study are WPO, 50D50W (50%Diesel + 50%WPO, 50D40W10MEA (50%Diesel + 40%WPO + 10%MEA and 50D40W10DEE (50%Diesel + 40%WPO + 10%DEE. The test results are compared with diesel. An increase in brake thermal efficiency and abatement in brake specific fuel consumption are seen with 50D40W10MEA, as well as reduction in hydro carbon, carbon monoxide and smoke emissions. 50D40W10DEE showed reduced NOx emission whereas 50D40W10MEA has almost no impact. Engine performance and emission characteristics under different loads for different test fuels are discussed. Keywords: 2-Methoxy ethyl acetate, Diethyl ether, Waste plastic oil, Pyrolysis

  1. Solubility and viscosity for CO_2 capture process using MEA promoted DEAE aqueous solution

    International Nuclear Information System (INIS)

    Fu, Dong; Wang, LeMeng; Zhang, Pan; Mi, ChenLu

    2016-01-01

    Highlights: • Solubility of CO_2 in MEA promoted DEAE aqueous solution was measured. • Mass fraction and temperature dependences of solubility were illustrated. • Viscosities of carbonated MEA–DEAE solutions were measured and calculated. • Temperature, mass fraction and CO_2 loading dependences of viscosity were illustrated. - Abstract: The saturated solubility of CO_2 in monoethanolamine (MEA) promoted 2-diethylaminoethanol (DEAE) aqueous solution was investigated at temperatures ranging from (303.2 to 323.2) K. The mass fraction and temperature dependences of the saturated solubility and CO_2 loading are illustrated. The viscosities of both CO_2-unloaded and CO_2-loaded DEAE–MEA aqueous solutions were measured and then calculated by using the Weiland equation. The effects of temperature, mass fraction and CO_2 loading on viscosities are demonstrated.

  2. Freezing Point Depressions of Aqueous MEA, MDEA, and MEA−MDEA Measured with a New Apparatus

    DEFF Research Database (Denmark)

    Fosbøl, Philip Loldrup; Pedersen, Mikkel Gielsager; Thomsen, Kaj

    2011-01-01

    Freezing points for aqueous monoethanolamine (MEA), methyl diethanolamine (MDEA), and MEA−MDEA solutions were measured in the concentration range from 0 to 0.4 mass fractions of the alkanolamines. For the aqueous MEA−MDEA system, freezing points for 1:4, 1:2, 1:1, 2:1, and 4:1 molar ratios of MEA....../MDEA were determined. The experimental values indicate that the MDEA−water interaction is stronger than the MEA−water interaction. Measurements were carried out by a new modified Beckmann apparatus, which has not previously been described. The apparatus and method proved to have good repeatability...

  3. Casa mea cetatea mea. Recenzie la cartea - Mette Svart Kristiansen, Kate Giles (eds, Dwellings, Identities and Homes. European Housing Culture from the Viking Age to the Renaissance, Jutland Archaeological Society, Aarhus University Press, 2014

    Directory of Open Access Journals (Sweden)

    Sergiu Musteata

    2015-12-01

    Full Text Available Review of the book - Casa mea cetatea mea. Recenzie la cartea - Mette Svart Kristiansen, Kate Giles (eds, Dwellings, Identities and Homes. European Housing Culture from the Viking Age to the Renaissance, Jutland Archaeological Society, Aarhus University Press, 2014

  4. Dynamic simulation and analysis of a pilot-scale CO2 post-combustion capture unit using piperazine and MEA

    DEFF Research Database (Denmark)

    Gaspar, Jozsef; Ricardez-Sandoval, Luis; Jørgensen, John Bagterp

    2016-01-01

    show the results for the baseline 30 wt% MEA and the low energy piperazine (PZ) solutions. This analysis reveals that the absorber reaches steady-state faster using MEA compared to PZ. This is related to the shift of the mass transfer zone due to changes in temperature. The transient operation...

  5. MEA [Municipal Electric Association] declares opposition to 1991 Ontario Hydro rate increase

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    In hearings before the Ontario Energy Board, the Municipal Electric Association (MEA) called for an average 1992 rate increase of 10.3%, lower than Ontario Hydro's revised figure of 10.4%, and a $129 million reduction in its operations, maintenance and administration budget. As it has been noted that Hydro pays considerably higher wages than the surrounding reference community, MEA recommended that the utility reduce and eventually eliminate the premium paid to employees, and also called for staff reductions and layoffs for 1991 and 1992. In the area of transmission reliability, MEA stated that Ontario Hydro's transmission maintenance is suffering at the expense of other priorities, and called for reorganizing its transmission plan to achieve target performance by 1996 rather than 1999. In 1991, only 65-70% of maintenance targets were being achieved. MEA also accused Hydro of deferring operational expenditures into deferment and capitalization, creating a false picture of the utility's financial condition. Also discussed at the hearing were the possible overestimating of the effects of Ontario Hydro's demand management programs, the possibility that a shift to time-of-use rates for industrial customers may increase demand, a downgrading of the province's and the utility's credit rating, and the unpleasant side effects of the non-utility generation program

  6. Final Report - Membranes and MEA's for Dry, Hot Operating Conditions

    Energy Technology Data Exchange (ETDEWEB)

    Hamrock, Steven J

    2011-06-30

    The focus of this program was to develop a new Proton Exchange Membrane (PEM) which can operate under hotter, dryer conditions than the state of the art membranes today and integrate it into a Membrane Electrode Assembly (MEA). These MEA's should meet the performance and durability requirements outlined in the solicitation, operating under low humidification conditions and at temperatures ranging from -20ºC to 120ºC, to meet 2010 DOE technical targets for membranes. This membrane should operate under low humidification conditions and at temperatures ranging from -20ºC to 120ºC in order to meet DOE HFCIT 2010 commercialization targets for automotive fuel cells. Membranes developed in this program may also have improved durability and performance characteristics making them useful in stationary fuel cell applications. The new membranes, and the MEA's comprising them, should be manufacturable at high volumes and at costs which can meet industry and DOE targets. This work included: A) Studies to better understand factors controlling proton transport within the electrolyte membrane, mechanisms of polymer degradation (in situ and ex situ) and membrane durability in an MEA; B) Development of new polymers with increased proton conductivity over the range of temperatures from -20ºC to 120ºC and at lower levels of humidification and with improved chemical and mechanical stability; C) Development of new membrane additives for increased durability and conductivity under these dry conditions; D) Integration of these new materials into membranes and membranes into MEA's, including catalyst and gas diffusion layer selection and integration; E) Verification that these materials can be made using processes which are scalable to commercial volumes using cost effective methods; F) MEA testing in single cells using realistic automotive testing protocols. This project addresses technical barriers A (Durability) and C (Performance) from the Fuel Cells section of the

  7. Diagnosis of Glanzmann thrombasthenia by whole blood impedance analyzer (MEA) vs. light transmission aggregometry.

    Science.gov (United States)

    Albanyan, A; Al-Musa, A; AlNounou, R; Al Zahrani, H; Nasr, R; AlJefri, A; Saleh, M; Malik, A; Masmali, H; Owaidah, T

    2015-08-01

    Glanzmann thrombasthenia (GT) is a rare inherited platelet disorder that is characterized by spontaneous or postprocedural bleeding. The diagnosis of GT depends on identifying the dysfunction of the platelets. The aim of this study was to compare a whole blood impedance Multiplate analyzer (MEA) with the standard method, light transmission aggregometry (LTA) in diagnosis of GT. Fifteen patients with GT were assessed on MEA and LTA using arachidonic acid (ASPI: 15 mm), (TRAP: 1 mm), collagen (100 μg/mL), ADP (0.2 mm), and ristocetin (Risto: 10 mg/mL). Whole blood samples were collected in sodium citrate and hirudin vacuum, blood collection tubes and tested within 4 h. Platelet-rich plasma was used for LTA using platelet agonists (ristocetin 1.5 mg/mL) (arachidonic acid 0.5 mg/mL) (ADP 2.5 mg/mL) and (collagen 1 mg/mL). The platelet count and PFA-100 results were (average and SD) 319 ± 93 × 10(9) L and 252 ± 34 s, respectively. Flow cytometry analysis showed that all samples are positive for CD42a and CD42b, whereas 9/15 samples were negative for CD61 and CD41. The other six patients had either partial or full expression of CD61/CD41. Aggregation analysis using both methods showed that all samples had no aggregation response to any of the agonists used apart from six samples which, using only the MEA, showed minimal aggregation in response to collagen (average = 14.3 ± 7 μg, which may suggest ability to detect qualitative abnormality of GPIIb/IIIa). These results suggest that the MEA is sensitive for the detection of Glanzmann thrombasthenia. Furthermore, MEA may also be able to differentiate between the subtypes of Glanzmann thrombasthenia. © 2014 John Wiley & Sons Ltd.

  8. Intensive time series data exploitation: the Multi-sensor Evolution Analysis (MEA) platform

    Science.gov (United States)

    Mantovani, Simone; Natali, Stefano; Folegani, Marco; Scremin, Alessandro

    2014-05-01

    The monitoring of the temporal evolution of natural phenomena must be performed in order to ensure their correct description and to allow improvements in modelling and forecast capabilities. This assumption, that is obvious for ground-based measurements, has not always been true for data collected through space-based platforms: except for geostationary satellites and sensors, that allow providing a very effective monitoring of phenomena with geometric scale from regional to global; smaller phenomena (with characteristic dimension lower than few kilometres) have been monitored with instruments that could collect data only with a time interval in the order of several days; bi-temporal techniques have been the most used ones for years, in order to characterise temporal changes and try identifying specific phenomena. The more the number of flying sensor has grown and their performance improved, the more their capability of monitoring natural phenomena at a smaller geographic scale has grown: we can now count on tenth of years of remotely sensed data, collected by hundreds of sensors that are now accessible from a wide users' community, and the techniques for data processing have to be adapted to move toward a data intensive exploitation. Starting from 2008, the European Space Agency has initiated the development of the Multi-sensor Evolution Analysis (MEA) platform (https://mea.eo.esa.int), whose first aim was to permit the access and exploitation of long term remotely sensed satellite data from different platforms: 15 years of global (A)ATSR data together with 5 years of regional AVNIR-2 data were loaded into the system and were used, through a web-based graphic user interface, for land cover change analysis. The MEA data availability has grown during years integrating multi-disciplinary data that feature spatial and temporal dimensions: so far tenths of Terabytes of data in the land and atmosphere domains are available and can be visualized and exploited, keeping the

  9. Controllability and flexibility analysis of CO2 post-combustion capture using piperazine and MEA

    DEFF Research Database (Denmark)

    Gaspar, Jozsef; Ricardez-Sandoval, Luis; Jørgensen, John Bagterp

    2016-01-01

    In this study, we developed a decentralized control scheme and investigate the performance of the piperazine (PZ) and monoethanolamine (MEA) CO2 capture process for industrially-relevant operation scenarios. The base for the design of the control schemes is Relative Gain Array (RGA) analysis...... indicates that the proposed PI-based control structure can handle large changes in the load provided that the manipulated variables, i.e. lean solvent flow or reboiler duty, do not reach their saturation limit. Additionally, we observed that shortage in the steam supply (reboiler duty) may represent...... a critical operational bottleneck, especially when PZ is being used. The MEA plant controllers drive the system towards drying out/flooding while the CO2 capture rate performance of the PZ plant reduces drastically in the presence of constraints in the availability of steam. These findings suggest the need...

  10. Study on CO{sub 2} absorption enhancement by adding active carbon particles into MEA solution

    Energy Technology Data Exchange (ETDEWEB)

    Qian, Juan; Sun, Rui; Ma, Lian; Sun, Shaozeng [Harbin Institute of Technology, Harbin (China). School of Energy Science and Engineering

    2013-07-01

    The chemical absorption of CO{sub 2} is generally recognized as the most efficient post-combustion technology of CO{sub 2} separation at present. A study on CO{sub 2} absorption enhancement by adding small particles of active carbon into MEA solution is investigated within a self-designed glass stirring tank. Experiments of different particle loadings and different particle sizes have been conducted. When active carbon particle concentration is fewer, compared to the absorption rate of CO{sub 2} gas absorbed by MEA aqueous solution, the role of active carbon adsorption CO{sub 2} gas is negligible. The enhancement efficiency of CO{sub 2} absorption could be improved by 10% to the upmost in this liquid-particle system.

  11. Mass transfer and thermodynamic modeling of carbon dioxide absorption into MEA aqueous solution

    Directory of Open Access Journals (Sweden)

    Ghaemi Ahad

    2017-09-01

    Full Text Available In this research, thermodynamic and absorption rate of carbon dioxide in monoethanolamine (MEA solution was investigated. A correlation based on both liquid and a gas phase variable for carbon dioxide absorption rate was presented using the π-Buckingham theorem. The correlation was constructed based on dimensionless numbers, including carbon dioxide loading, carbon dioxide partial pressure, film parameter and the ratio of liquid phase film thickness and gas phase film thickness. The film parameter is used to apply the effect of chemical reactions on absorption rate. A thermodynamic model based on the extended-UNIQUAC equations for the activity coefficients coupled with the Virial equation of state for representing the non-ideality of the vapor phase was used to predict the CO2 solubility in the CO2-MEA-H2O system. The average absolute error of the results for the correlation was 6.4%, which indicates the accuracy of the proposed correlation.

  12. Mixed hydrocarbon/fluoropolymer membrane/ionomer MEAs for durability studies

    Energy Technology Data Exchange (ETDEWEB)

    Li, Bo [Los Alamos National Laboratory; Kim, Yu Seung [Los Alamos National Laboratory; Mukundan, Rangachary [Los Alamos National Laboratory; Borup, Rodney L [Los Alamos National Laboratory; Wilson, Mahlon S [Los Alamos National Laboratory; Welch, Cynthia [Los Alamos National Laboratory; Fenton, James [FLORIDA SOLAR ENERGY CENTER

    2010-01-01

    The durability of polymer electrolyte membrane (PEM) fuel cells is a major barrier to the commercialization of these systems for stationary and transportation power applications. Commercial viability depends on improving the durability of the fuel cell components to increase the system reliability. The aim of this work is to separate ionomer degradation from membrane degradation via mixed membrane/ionomer MEA experiments. The challenges of mixed MEA fabrication due to the incompatibility of the membrane and the electrode are addressed. OCV accelerated testing experiment (AST) were performed. Development of in situ diagnostics and unique experiments to characterize the performance and properties of the ionomer in the electrode as a function of time is reported. These measurements, along with extensive ex situ and post-mortem characterization, can delineate the degradation mechanisms in order to develop more durable fuel cells and fuel cell components.

  13. Analysis of creative mathematical thinking ability by using model eliciting activities (MEAs)

    Science.gov (United States)

    Winda, A.; Sufyani, P.; Elah, N.

    2018-05-01

    Lack of creative mathematical thinking ability can lead to not accustomed with open ended problem. Students’ creative mathematical thinking ability in the first grade at one of junior high school in Tangerang City is not fully developed. The reason of students’ creative mathematical thinking ability is not optimally developed is so related with learning process which has done by the mathematics teacher, maybe the learning design that teacher use is unsuitable for increasing students’ activity in the learning process. This research objective is to see the differences in students’ ways of answering the problems in terms of students’ creative mathematical thinking ability during the implementation of Model Eliciting Activities (MEAs). This research use post-test experimental class design. The indicators for creative mathematical thinking ability in this research arranged in three parts, as follow: (1) Fluency to answer the problems; (2) Flexibility to solve the problems; (3) Originality of answers. The result of this research found that by using the same learning model and same instrument from Model Eliciting Activities (MEAs) there are some differences in the way students answer the problems and Model Eliciting Activities (MEAs) can be one of approach used to increase students’ creative mathematical thinking ability.

  14. Performance of an Active Micro Direct Methanol Fuel Cell Using Reduced Catalyst Loading MEAs

    Directory of Open Access Journals (Sweden)

    D.S. Falcão

    2017-10-01

    Full Text Available The micro direct methanol fuel cell (MicroDMFC is an emergent technology due to its special interest for portable applications. This work presents the results of a set of experiments conducted at room temperature using an active metallic MicroDMFC with an active area of 2.25 cm2. The MicroDMFC uses available commercial materials with low platinum content in order to reduce the overall fuel cell cost. The main goal of this work is to provide useful information to easily design an active MicroDMFC with a good performance recurring to cheaper commercial Membrane Electrode Assemblies MEAs. A performance/cost analysis for each MEA tested is provided. The maximum power output obtained was 18.1 mW/cm2 for a hot-pressed MEA with materials purchased from Quintech with very low catalyst loading (3 mg/cm2 Pt–Ru at anode side and 0.5 mg/cm2 PtB at the cathode side costing around 15 euros. Similar power values are reported in literature for the same type of micro fuel cells working at higher operating temperatures and substantially higher cathode catalyst loadings. Experimental studies using metallic active micro direct methanol fuel cells operating at room temperature are very scarce. The results presented in this work are, therefore, very useful for the scientific community.

  15. Detailed H2 and CO Electrochemistry for a MEA Model Fueled by Syngas

    KAUST Repository

    Lee, W. Y.

    2015-07-17

    © The Electrochemical Society. SOFCs can directly oxidize CO in addition to H2, which allows them to be coupled to a gasifier. Many membrane-electrode-assembly (MEA) models neglect CO electrochemistry due to sluggish kinetics and the water-gas-shift reaction, but CO oxidation may be important for high CO-content syngas. The 1D-MEA model presented here incorporates detailed mechanisms for both H2 and CO oxidation, individually fitted to experimental data. These mechanisms are then combined into a single model, which provides a good fit to experimental data for H2/CO mixtures. Furthermore, the model fits H2/CO data best when a single chargetransfer step in the H2 mechanism is assumed to be rate-limiting for all current densities. This differs from the result for H2/H2O mixtures, where H2 adsorption becomes rate-limiting at high current densities. These results indicate that CO oxidation cannot be neglected in MEA models running on CO-rich syngas, and that CO oxidation can alter the H2 oxidation mechanism.

  16. PEMFC performance of MEAS based on Nafion{sup R} and sPSEBS hybrid membranes

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez-Carretero, F.J.; Compan, V. [Univ, Politecnica de Valencia, Valencia (Spain). Dept. Termodinamica Aplicada; Suarez, K.; Solorza, O. [Inst. Politecnico Nacional, Centro de Investigacion y de Estudios Avanzados, Mexico City (Mexico). Dept. de Quimica; Riande, E. [Inst. de Ciencia y Tecnologia de Polimeros, Madrid (Spain)

    2010-07-15

    Important scientific, technical and economic problems must be solved before widespread commercialization of polymer electrolyte membrane fuel cells (PEMFC). The main issues facing the development of commercial low temperature fuel cells are the synthesis of efficient solid electrolytes separating the anode from the cathode as well as the development of cheaper catalysts for fuel oxidation. This study involved the preparation of hybrid membranes based on Nafion 117 and sulfonated Calprene H6120 containing partially sulfonated inorganic fillers such as silica, SBA-15 and sepiolite. The feasibility of using the membranes as polyelectrolytes for low temperature fuel cells was then evaluated. The water uptake of Nafion hybrid membranes is 1/3 to 1/4 of that in composite membranes based on sulfonated Calprene H6120. The proton conductivity of Nafion 117 hybrid membranes-electrode assemblies is nearly 1/5 of the pristine Nafion membrane assembly. Sulfonated Calprene H6120 hybrid membranes typically have better proton conductivity than the Nafion 117 composites. The performance of fuel cells containing different MEAs was examined by measuring their polarization curves in different operating conditions. The kinetic parameters governing the voltage dependence on current density were also estimated. It was concluded that the superior performance of the fuel cells with MEAs of NAF-SEP, sPSEBS-SIL and sPSEBS-SBA is not due to the membranes themselves, but to the kinetic processes that occur at the electrodes, which in this study were less efficient for fuel cells with the Nafion MEA. 34 refs., 3 tabs., 9 figs.

  17. Feasibility assessment of Micro electrode chip assay (MEA as a method of detecting neurotoxicity in vitro

    Directory of Open Access Journals (Sweden)

    Enrico eDefranchi

    2011-04-01

    Full Text Available Detection and characterization of chemically-induced toxic effects in the nervous system represent a challenge for the hazard assessment of chemicals. In vivo, neurotoxicological assessments exploit the fact that the activity of neurons in the central and peripheral nervous system has functional consequences. And so far, no in vitro method for evaluating the neurotoxic hazard has yet been validated and accepted for regulatory purpose.The microelectrode array (MEA assay consists of a culture chamber into which an integrated array of microelectrodes is capable of measuring extracellular electrophysiology (spikes and bursts from electro-active tissues. A wide variety of electrically excitable biological tissues may be placed onto the chips including primary cultures of nervous system tissue. Recordings from this type of in vitro cultured system are non invasive, give label free evaluations and provide a higher throughput than conventional electrophysiological techniques. In this paper, twenty substances were tested in a blinded study for their toxicity and dose-response curves were obtained from foetal rat cortical neuronal networks coupled to MEAs. The experimental procedure consisted of evaluating the firing activity (spiking rate and modification/reduction in response to chemical administration. Native/reference activity, 30 minutes of activity recording per dilution, plus the recovery points (after 24 hours were recorded. The preliminary data, using a set of chemicals with different mode-of-actions (13 known to be neurotoxic, 2 non-neuroactive and not toxic and 5 non-neuroactive but toxic show good predictivity (sensitivity: 0.77; specificity: 0.86; accuracy: 0.85. Thus, the MEA with a neuronal network has the potency to become an effective tool to evaluate the neurotoxicity of substances in vitro.

  18. Neurotoxicity screening of (illicit) drugs using novel methods for analysis of microelectrode array (MEA) recordings.

    Science.gov (United States)

    Hondebrink, L; Verboven, A H A; Drega, W S; Schmeink, S; de Groot, M W G D M; van Kleef, R G D M; Wijnolts, F M J; de Groot, A; Meulenbelt, J; Westerink, R H S

    2016-07-01

    Annual prevalence of the use of common illicit drugs and new psychoactive substances (NPS) is high, despite the often limited knowledge on the health risks of these substances. Recently, cortical cultures grown on multi-well microelectrode arrays (mwMEAs) have been used for neurotoxicity screening of chemicals, pharmaceuticals, and toxins with a high sensitivity and specificity. However, the use of mwMEAs to investigate the effects of illicit drugs on neuronal activity is largely unexplored. We therefore first characterised the cortical cultures using immunocytochemistry and show the presence of astrocytes, glutamatergic and GABAergic neurons. Neuronal activity is concentration-dependently affected following exposure to six neurotransmitters (glutamate, GABA, serotonin, dopamine, acetylcholine and nicotine). Most neurotransmitters inhibit neuronal activity, although glutamate and acetylcholine transiently increase activity at specific concentrations. These transient effects are not detected when activity is determined during the entire 30min exposure window, potentially resulting in false-negative results. As expected, exposure to the GABAA-receptor antagonist bicuculline increases neuronal activity. Exposure to a positive allosteric modulator of the GABAA-receptor (diazepam) or to glutamate receptor antagonists (CNQX and MK-801) reduces neuronal activity. Further, we demonstrate that exposure to common drugs (3,4-methylenedioxymethamphetamine (MDMA) and amphetamine) and NPS (1-(3-chlorophenyl)piperazine (mCPP), 4-fluoroamphetamine (4-FA) and methoxetamine (MXE)) decreases neuronal activity. MXE most potently inhibits neuronal activity with an IC50 of 0.5μM, whereas 4-FA is least potent with an IC50 of 113μM. Our data demonstrate the importance of analysing neuronal activity within different time windows during exposure to prevent false-negative results. We also show that cortical cultures grown on mwMEAs can successfully be applied to investigate the effects of

  19. LP DAAC MEaSUREs Project Artifact Tracking Via the NASA Earthdata Collaboration Environment

    Science.gov (United States)

    Bennett, S. D.

    2015-12-01

    The Land Processes Distributed Active Archive Center (LP DAAC) is a NASA Earth Observing System (EOS) Data and Information System (EOSDIS) DAAC that supports selected EOS Community non-standard data products such as the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) Global Emissivity Database (GED), and also supports NASA Earth Science programs such as Making Earth System Data Records for Use in Research Environments (MEaSUREs) to contribute in providing long-term, consistent, and mature data products. As described in The LP DAAC Project Lifecycle Plan (Daucsavage, J.; Bennett, S., 2014), key elements within the Project Inception Phase fuse knowledge between NASA stakeholders, data producers, and NASA data providers. To support and deliver excellence for NASA data stewardship, and to accommodate long-tail data preservation with Community and MEaSUREs products, the LP DAAC is utilizing NASA's own Earthdata Collaboration Environment to bridge stakeholder communication divides. By leveraging a NASA supported platform, this poster describes how the Atlassian Confluence software combined with a NASA URS/Earthdata support can maintain each project's members, status, documentation, and artifact checklist. Furthermore, this solution provides a gateway for project communities to become familiar with NASA clients, as well as educating the project's NASA DAAC Scientists for NASA client distribution.

  20. ANALISIS TINGKAT KAPABILITAS SISTEM INFORMASI RUMAH SAKIT BERDASARKAN COBIT 5 (MEA01 PADA RSUD TUGUREJO SEMARANG

    Directory of Open Access Journals (Sweden)

    Ariel Bagus Nugroho

    2015-11-01

    Full Text Available RSUD Tugurejo Semarang merupakan Rumah Sakit kelas B milik pemerintah Provinsi Jawa Tengah yang menyediakan pelayanan jasa untuk masyarakat. Dalam manajemen pengolahan data, RSUD Tugurejo Semarang telah menggunakan sistem informasi rumah sakit. Untuk mengetahui apakah sistem informasi telah berjalan seperti yang diharapkan, maka perlu dilakukan analisis tatakelola teknologi informasi. Pada penelitian ini analisis tatakelola teknologi informasi berfokus pada proses pengawasan, evaluasi dan penilaian kinerja, dan kesesuaian kinerja teknologi informasi, yaitu domain MEA01 pada framework COBIT 5.Tujuan penelitian ini untuk mengetahui tingkat kapabilitas dan strategi perbaikan untuk proses pengawasan, evaluasi dan penilaian kinerja dan kesesuaian TI. Metode pengumpulan  data penelitian ini dengan menggunakan studi dokumen, kuesioner dan wawancara kemudian dianalisis tingkat kapabilitas dan kesenjangan. Tingkat kapabilitas yang didapat dari hasil penelitian yaitu berada level 2 (managed. Untuk menaikkan tingkat kapabilitas pada level 3 maka maka perlu dilakukan secara bertahap strategi perbaikan pada PA 2.1, PA2.2, PA 3.1, dan 3.2. Kata kunci: Analisis Tata Kelola TI, COBIT 5, MEA01, Tingkat Kapabilitas, Rumah Sakit.

  1. Oxidation inhibitors for aqueous MEA solutions used in a post-combustion CO{sub 2} capture process

    Energy Technology Data Exchange (ETDEWEB)

    Carrette, P.L.; Bonnard, L. [IFP, Solaize (France); Delfort, B. [IFP, Rueil-Malmaison (France)

    2009-07-01

    This study examined the feasibility of using an aqueous solution of MEA as a solvent for post- combustion capture of carbon dioxide (CO{sub 2}). MEA is inexpensive, largely available, non toxic and highly effective because of its high capacity for CO{sub 2} capture and its fast reaction kinetics. However, significant oxidative degradation occurs when MEA is exposed to oxygen. Oxidation of MEA is not only a source of solvent consumption but also creates volatile compounds such as ammonia and carboxylic acids that can cause corrosion. As such, degradation control is a major challenge. Oxidative degradation can potentially be solved by the use of antioxidant additives. This presentation reported on a laboratory scale evaluation test of MEA degradation associated with analysis of degradation products. Different antioxidant additives were then evaluated. Conventional antioxidant additives were found to be poorly active or inactive, and some even exhibited a pronounced effect upon degradation. New classes of additives have been found to be effective in considerably reducing degradation.

  2. Performance degradation and microstructure changes in freeze-thaw cycling for PEMFC MEAs with various initial microstructures

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sang-Yeop; Kim, Hyoung-Juhn; Cho, EunAe; Lee, Kug-Seung; Lim, Tae-Hoon; Jang, Jong Hyun [Fuel Cell Center, Korea Institute of Science and Technology (KIST), Seoul 136-791 (Korea, Republic of); Hwang, In Chul [Corporate Research and Development Division, Hyundai-Kia Motors, Gyeonggi-do 446-912 (Korea, Republic of)

    2010-12-15

    When the temperature of a fuel cell vehicle is repeatedly reduced to subzero temperatures, volume changes by water/ice transformations and frost heave mechanism can cause microstructural changes in membrane-electrode assemblies (MEA), and a resultant permanent decrease in the performance of fuel cell stacks. In this study, five MEAs manufactured by different methods, were tested under repeated freeze-thaw (F-T) cycles between -20 C and 10 C, and the variations in their electrochemical and microstructural characteristics were analyzed according to the initial microstructures. When the MEAs were prepared by spraying catalyst inks on polymer membranes, no significant microstructural changes were observed. In the case of two supplied MEAs, void formations at the electrolyte/electrode interface or vertical cracks within the catalyst layers were observed after 120 F-T cycles. Void formation seems to be responsible for performance degradation as a result of ohmic loss, but the effect of cracks in the catalyst layers was not confirmed. In 120 F-T cycles, activation overpotentials and concentration overpotentials did not increase significantly for any of the MEAs, even although gradual decreases in the electrochemically active surface area of the platinum catalysts and changes in the porous structure were observed. (author)

  3. Energy Consumption and Greenhouse Gas Emission Evaluation Scenarios of Mea Fah Luang University

    Directory of Open Access Journals (Sweden)

    Laingoen Onn

    2016-01-01

    Full Text Available In Thailand, quantity of the educational institutes building shared one fourth of commercial building. Among the energy consumption and conservation in the building in Thailand are mostly study in typical office and resident building. Mea Fah Luang University (MFU was selected to represent the educational institutes building where located in the northern part of Thailand. The average temperature in the northern is lower than other parts of Thailand. This study was firstly collected the data about quantity and behaviour of energy consumption in MFU based on the energy audit handbook. Although MFU is located in the northern of Thailand. The highest energy consumption is in the part of air condition. When the energy efficiency appliances and energy conservation building are implemented, the cost of energy will be saved around 15,867,960 Baht. Furthermore, the greenhouse gas emission is also reduced about 72.01 kg CO2, equivalent/m2/year.

  4. Proper Estimation of the Energy Consumption in A Carbon Dioxide-MEA Stripper

    DEFF Research Database (Denmark)

    Madeddu, Claudio; Errico, Massimiliano; Baratti, Roberto

    In the field of CCS, the chemical absorption/desorption using amines represents one of the most easily implemented process for the reduction of the carbon dioxide generated by combustion plants. The high energy consumption in the solvent regeneration section represents the major concern for its...... fully industrial application. In the design of a carbon dioxide-MEA stripper, once the process targets are fixed, the estimation of the reboiler duty represents a crucial point for what concerns the quantification of the energy requirement. Furthermore, the vapor flow produced in the reboiler influences...... in simultaneous multicomponent material transfer, energy transfer and chemical reactions, is fundamental for an accurate design of the system. In this work the solvent regeneration section of a pilot-plant post-combustion CO2 capture facility was modeled using a rate-based approach, focusing on some key...

  5. Experimental characterization and modeling of commercial polybenzimidazole-based MEA performance

    DEFF Research Database (Denmark)

    Korsgaard, Anders; Refshauge, R. H.; Nielsen, Mads Pagh

    2006-01-01

    are currently published to enable good system design and modeling. In this paper the influence of operation on synthesis gas and the variation of the cathode stoichiometry are investigated based on a generic commercial membrane electrode assembly (MEA). The CO content in the anode gas was varied from 0 to 5......%, with CO2 contents ranging from 25 to 20% at temperatures ranging from 160 to 200 °C. The influence of the cathode stoichiometry was investigated in the interval of 2-5 at temperatures from 120 to 180 °C with pure hydrogen on the anode. A novel semi empirical model of the fuel cell voltage versus current...... density, cathode stoichiometry and temperature was derived. It shows excellent agreement with the experimental data. The simplicity and accuracy of the model makes it ideal for system modeling, control design and real-time applications....

  6. Marine ecosystem acoustics (MEA): Quantifying processes in the sea at the spatio-temporal scales on which they occur

    KAUST Repository

    Godø l, Olav Rune; Handegard, Nils Olav; Browman, Howard I.; MacAulay, Gavin J.; Kaartvedt, Stein; Giske, Jarl; Ona, Egil; Huse, Geir; Johnsen, Espen

    2014-01-01

    information by taxon at the relevant scales. The gaps between single-species assessment and ecosystem-based management, as well as between fisheries oceanography and ecology, are thereby bridged. The MEA concept combines state-of-the-art acoustic technology

  7. Marine ecosystem acoustics (MEA): Quantifying processes in the sea at the spatio-temporal scales on which they occur

    KAUST Repository

    Godøl, Olav Rune

    2014-07-22

    Sustainable management of fisheries resources requires quantitative knowledge and understanding of species distribution, abundance, and productivity-determining processes. Conventional sampling by physical capture is inconsistent with the spatial and temporal scales on which many of these processes occur. In contrast, acoustic observations can be obtained on spatial scales from centimetres to ocean basins, and temporal scales from seconds to seasons. The concept of marine ecosystem acoustics (MEA) is founded on the basic capability of acoustics to detect, classify, and quantify organisms and biological and physical heterogeneities in the water column. Acoustics observations integrate operational technologies, platforms, and models and can generate information by taxon at the relevant scales. The gaps between single-species assessment and ecosystem-based management, as well as between fisheries oceanography and ecology, are thereby bridged. The MEA concept combines state-of-the-art acoustic technology with advanced operational capabilities and tailored modelling integrated into a flexible tool for ecosystem research and monitoring. Case studies are presented to illustrate application of the MEA concept in quantification of biophysical coupling, patchiness of organisms, predator-prey interactions, and fish stock recruitment processes. Widespread implementation of MEA will have a large impact on marine monitoring and assessment practices and it is to be hoped that they also promote and facilitate interaction among disciplines within the marine sciences.

  8. Techno-economic comparison of combined cycle gas turbines with advanced membrane configuration and MEA solvent at part load conditions

    NARCIS (Netherlands)

    Van Der Spek, Mijndert; Bonalumi, Davide; Manzolini, Giampaolo; Ramirez, Andrea; Faaij, André P.C.

    2018-01-01

    This work compares the part load techno-economic performance of CO2 capture from a CCGT using a membrane configuration with selective CO2 recycle and using MEA solvent, under the assumption of flexible power plant dispatch. This is the first time that the techno-economic performance of CO2 capture

  9. Development of more efficient and cheaper MEA's for PEM fuel cells; Membrane-electrode-assembly

    Energy Technology Data Exchange (ETDEWEB)

    Yde Andersen, S. (IRD Fuel Cell A/S, Svendborg (Denmark)); Nilsson, M.S. (Danish Power System Aps, Charlottenlund (Denmark)); Siu, A.; Plackett, D. (Technical Univ. of Denmark. Risoe National Lab. for Sustainable Energy, Dansk Polymer Center, Roskilde (Denmark)); Li, Q. (Technical Univ. of Denmark, Dept. of Chemistry, Kgs. Lyngby (Denmark))

    2008-06-15

    The project covered 5 main areas: 1) polymer and membranes; 2) electrocatalysts; 3) gas diffusion electrodes; 4) MEAs; and 5) evaluation techniques. For the polymers, by purification of monomers and optimizing parameters, high molecular weight polybenzimidazoles have been synthesized in batches of 50 g with good reproducibility. Based on the polymer, two types of new membranes have been prepared. One is the cross-linked (covalently and acid-base) PBI blend membranes. The blend membranes were systematically characterized and show excellent properties such as very high acid doping levels, conductivity, mechanical strength and durability. The other type is composite membranes based on PBI and nanoclay. Using the modified nanoclay, good dispersion and transparent composite membranes have been achieved. For catalyst preparation, the carbon supports have been modified with thermal treatment. Improved corrosion resistance was achieved with little sacrificing of the catalytic activity. High Pt loading catalysts were prepared, based on which high performance gas diffusion electrodes were fabricated. The performance target of both cathode and anode was achieved, as evaluated by the PTFE half cell tests. New gas diffusion layer (GDL) materials have been developed and tested in different MEA configurations. Significant performance improvement has been achieved with also potential to reduce the cost. Techniques for applying micro porous layers and catalyst layers have been optimized, including tape casting, spraying, and catalyst-coated membrane (CCM). Using the developed membranes and gas diffusion electrodes, membrane-electrode assemblies (MEAs) were fabricated for both single cell and stack tests. Selection of sealing materials and design of integrated gaskets have been made for both low and high temperature MEAs. Parameters for hot-pressing such as temperature, pressure and duration were systematically studied. 44 MEAs with an active area of 256 cm{sup 2} have been prepared

  10. Corticospinal signals recorded with MEAs can predict the volitional forearm forces in rats.

    Science.gov (United States)

    Guo, Yi; Mesut, Sahin; Foulds, Richard A; Adamovich, Sergei V

    2013-01-01

    We set out to investigate if volitional components in the descending tracts of the spinal cord white matter can be accessed with multi-electrode array (MEA) recording technique. Rats were trained to press a lever connected to a haptic device with force feedback to receive sugar pellets. A flexible-substrate multi-electrode array was chronically implanted into the dorsal column of the cervical spinal cord. Field potentials and multi-unit activities were recorded from the descending axons of the corticospinal tract while the rat performed a lever pressing task. Forelimb forces, recorded with the sensor attached to the lever, were reconstructed using the hand position data and the neural signals through multiple trials over three weeks. The regression coefficients found from the trial set were cross-validated on the other trials recorded on same day. Approximately 30 trials of at least 2 seconds were required for accurate model estimation. The maximum correlation coefficient between the actual and predicted force was 0.7 in the test set. Positional information and its interaction with neural signals improved the correlation coefficient by 0.1 to 0.15. These results suggest that the volitional information contained in the corticospinal tract can be extracted with multi-channel neural recordings made with parenchymal electrodes.

  11. Comparison of MEA capture cost for low CO{sub 2} emissions sources in Australia

    Energy Technology Data Exchange (ETDEWEB)

    Ho, M.T.; Allinson, G.W.; Wiley, D.E. [University of New South Wales, Sydney, NSW (Australia). School of Chemical Engineering

    2011-01-15

    This paper estimates the cost of CO{sub 2} capture for three Australian industrial emission sources: iron and steel production, oil refineries and cement manufacturing. It also compares the estimated capture costs with those of post-combustion capture from a pulverised black coal power plant. The cost of capture in 2008 using MEA solvent absorption technology ranges from less than A$60 per tonne CO{sub 2} avoided for the iron and steel production to over A$70 per tonne CO{sub 2} avoided for cement manufacture and over A$100 per tonne CO{sub 2} avoided for oil refineries. The costs of capture for the iron and steel and cement industries are comparable to or less than that for post-combustion capture from a pulverised black coal power plant. This paper also investigates costs for converting low partial pressure CO{sub 2} streams from iron and steel production to a more concentrated stream using pressurisation and the water-gas shift reaction. In those cases, the costs were found to be similar to or less than the cost estimates without conversion. The analyses in this paper also show that estimated costs are highly dependent on the characteristics of the industrial emission source, the assumptions related to the type and price of energy used by the capture facilities and the economic parameters of the project such as the discount rate and capital costs.

  12. Data Curation for the Exploitation of Large Earth Observation Products Databases - The MEA system

    Science.gov (United States)

    Mantovani, Simone; Natali, Stefano; Barboni, Damiano; Cavicchi, Mario; Della Vecchia, Andrea

    2014-05-01

    National Space Agencies under the umbrella of the European Space Agency are performing a strong activity to handle and provide solutions to Big Data and related knowledge (metadata, software tools and services) management and exploitation. The continuously increasing amount of long-term and of historic data in EO facilities in the form of online datasets and archives, the incoming satellite observation platforms that will generate an impressive amount of new data and the new EU approach on the data distribution policy make necessary to address technologies for the long-term management of these data sets, including their consolidation, preservation, distribution, continuation and curation across multiple missions. The management of long EO data time series of continuing or historic missions - with more than 20 years of data available already today - requires technical solutions and technologies which differ considerably from the ones exploited by existing systems. Several tools, both open source and commercial, are already providing technologies to handle data and metadata preparation, access and visualization via OGC standard interfaces. This study aims at describing the Multi-sensor Evolution Analysis (MEA) system and the Data Curation concept as approached and implemented within the ASIM and EarthServer projects, funded by the European Space Agency and the European Commission, respectively.

  13. Development of Nafion/tin oxide composite MEA for DMFC applications

    Energy Technology Data Exchange (ETDEWEB)

    Chen, F.; Mecheri, B.; D' Epifanio, A. [Department of Chemical Science and Technology, University of Rome ' Tor Vergata' , Via della Ricerca Scientifica, 00133 Rome (Italy); Traversa, E. [Department of Chemical Science and Technology, University of Rome ' Tor Vergata' , Via della Ricerca Scientifica, 00133 Rome (Italy); International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044 (Japan); Licoccia, S.

    2010-10-15

    Nafion composite membranes containing either hydrated tin oxide (SnO{sub 2}. nH{sub 2}O) or sulphated tin oxide (S-SnO{sub 2}) at 5 and 10 wt.-% were prepared and characterised. The structural and electrochemical features of the samples were investigated using X-ray diffraction, electrochemical impedance spectroscopy, methanol crossover and direct methanol fuel cell (DMFC) tests. Highest conductivity values were obtained by using S-SnO{sub 2} as filler (0.094 S cm{sup -1} at T = 110 C and RH = 100%). The presence of the inorganic compound resulted in lower methanol crossover and improved DMFC performance with respect to a reference unfilled membrane. To improve the interface of the membrane electrode assembly (MEA), a layer of the composite electrolyte (i.e. the Nafion membrane containing 5 wt.-% S-SnO{sub 2}) was brushed on the electrodes, obtaining a DMFC operating at 110 C with a power density (PD) of 100 mW cm{sup -2} which corresponds to a PD improvement of 52% with respect to the unfilled Nafion membrane. (Abstract Copyright [2010], Wiley Periodicals, Inc.)

  14. MultiElec: A MATLAB Based Application for MEA Data Analysis.

    Science.gov (United States)

    Georgiadis, Vassilis; Stephanou, Anastasis; Townsend, Paul A; Jackson, Thomas R

    2015-01-01

    We present MultiElec, an open source MATLAB based application for data analysis of microelectrode array (MEA) recordings. MultiElec displays an extremely user-friendly graphic user interface (GUI) that allows the simultaneous display and analysis of voltage traces for 60 electrodes and includes functions for activation-time determination, the production of activation-time heat maps with activation time and isoline display. Furthermore, local conduction velocities are semi-automatically calculated along with their corresponding vector plots. MultiElec allows ad hoc signal suppression, enabling the user to easily and efficiently handle signal artefacts and for incomplete data sets to be analysed. Voltage traces and heat maps can be simply exported for figure production and presentation. In addition, our platform is able to produce 3D videos of signal progression over all 60 electrodes. Functions are controlled entirely by a single GUI with no need for command line input or any understanding of MATLAB code. MultiElec is open source under the terms of the GNU General Public License as published by the Free Software Foundation, version 3. Both the program and source code are available to download from http://www.cancer.manchester.ac.uk/MultiElec/.

  15. Fabrication of MEMS-based 3D-μECoG-MEAs

    Directory of Open Access Journals (Sweden)

    Deckert Martin

    2016-09-01

    Full Text Available The microfabrication and packaging of novel, three-dimensional, polyimide-based, highly flexible, microscale electrocorticography multi-electrode arrays for enhanced epicortical recording of local field potentials is presented. A polyimide foil embeds metallic structures relating to 32 taper-type electrode sites, contact pads as well as interconnecting conductor paths which are integrated in the planar portion of the electrode substrate material. Circular exposed and, thus, active electrode sites are 50 μm in diameter and employed center-to-center pitches range from 250 μm to 1 mm, respectively. As-fabricated 3D-μECoG-MEAs provide taper heights of approximately 4 μm as well as 59 μm being distinguished by characteristic impedances of about 368.9 kΩ at 1 kHz measured in saline electrolyte. The applied packaging strategies favor flip-chip bonding and vapor phase soldering of the polymer substrates to customized printed circuit boards.

  16. In situ diagnostic of water distribution in thickness direction of MEA by neutron imaging. Focused on characteristics of water distribution in gas diffusion layer

    International Nuclear Information System (INIS)

    Tasaki, Yutaka; Ichikawa, Yasushi; Kobo, Norio; Shinohara, Kazuhiko; Boillat, Pierre; Kramer, Denis; Scherer, Gunther G.; Lehmann, Eberhard H.

    2008-01-01

    The mass transfer characteristics of gas diffusion layer (GDL) are closely related to cell performance in PEFC. In this study, In situ diagnostic of water distribution in thickness direction of MEA by Neutron Imaging has been carried out for three MEAs with different GDLs on cathode side as well as I-V characteristics. It was confirmed that this method is useful for analyzing water distribution in thickness direction of MEA. The relationship between I-V characteristics and liquid water distribution has been studied. (author)

  17. Does economic, financial and institutional developments matter for environmental quality? A comparative analysis of EU and MEA countries.

    Science.gov (United States)

    Abid, Mehdi

    2017-03-01

    The aim of this study is to test the hypothesis of the Environmental Kuznets Curve (EKC) with a sample of 58 MEA (Middle East & African) and 41 EU (European Union) countries for the period 1990 to 2011. The empirical analysis is carried out using the GMM-system method to solve the problem of endogenous variables. We focused on direct and indirect effects of institutional quality (through the efficiency of public expenditure, financial development, trade openness and foreign direct investment) and the income-emission relationship. We found a monotonically increasing relationship between CO 2 emissions and GDP in both MEA and EU regions. The policy implication is clear: in order to have sustainable positive economic performance and to reduce carbon dioxide emission in the country at the same time, policy makers should regulate and enhance the role and efficiency of domestic institutions. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Effects of AET, MEA, or 5-HT treatment before X-irradiation of pregnant C57B mice

    International Nuclear Information System (INIS)

    Mazur, L.

    1985-01-01

    C57B mice were either whole body X-irradiated with a dose of 200 R or, 15 minutes before X-radiation injected with AET, MEA, or 5-HT, in a dose of 40 mg/kg of body weight, on the first day of gestation. Uterine contents were examined on the nineteenth day of pregnancy. The number of corpora lutea was assumed as 100% and the percentage values of live and dead foetuses, resorptions, and non-implanted embryos were calculated. The percentage ratio of females with live foetuses in the uterus, in relation to the total number of those with a vaginal plug was also determined. X-irradiation of pregnant mice influenced the embryonic survival. As compared with controls, in only X-irradiated mice a lower percentage value of live foetuses and higher percentage values of non-implanted embryos and resorptions were found. One dead foetus was only observed in X-irradiated females. Percentage value of X-irradiated females with live foetuses was lower than that of control ones. High mortality of embryos occurred more often before than after the implantation of blastocysts. The percentage value of non-implanted embryos was higher than that of resorptions. AET, MEA, and 5-HT when injected to mice before their X-irradiation acted as radioprotectors. The strongest radioprotective effect was obtained following AET administration, intermediate after 5-HT treatment and the weakest one when MEA was injected. (orig.) [de

  19. Permeability changes and incorporation of labelled thymidine into DNA and whole cells of the fibroblast culture of Chinese hamsters affected by MEA and low temperature

    International Nuclear Information System (INIS)

    Ermekova, V.M.; Kondakova, N.V.; Levitman, M.Kh.; Saugabaeva, K.M.; Ehjdus, L.Kh.

    1976-01-01

    Action of MEA and low temperature (20degC) on the incorporation of labelled thymidine into DNA and whole cells of the fibroblast culture of chinese hamsters has been studied. It has been found that each of the above-mentioned factors equally decreases the label uptake into the cell and DNA. It is concluded that MEA and low temperature do not substantially influence the rate of DNA synthesis

  20. A Life Cycle Assessment Case Study of Coal-Fired Electricity Generation with Humidity Swing Direct Air Capture of CO2 versus MEA-Based Postcombustion Capture.

    Science.gov (United States)

    van der Giesen, Coen; Meinrenken, Christoph J; Kleijn, René; Sprecher, Benjamin; Lackner, Klaus S; Kramer, Gert Jan

    2017-01-17

    Most carbon capture and storage (CCS) envisions capturing CO 2 from flue gas. Direct air capture (DAC) of CO 2 has hitherto been deemed unviable because of the higher energy associated with capture at low atmospheric concentrations. We present a Life Cycle Assessment of coal-fired electricity generation that compares monoethanolamine (MEA)-based postcombustion capture (PCC) of CO 2 with distributed, humidity-swing-based direct air capture (HS-DAC). Given suitable temperature, humidity, wind, and water availability, HS-DAC can be largely passive. Comparing energy requirements of HS-DAC and MEA-PCC, we find that the parasitic load of HS-DAC is less than twice that of MEA-PCC (60-72 kJ/mol versus 33-46 kJ/mol, respectively). We also compare other environmental impacts as a function of net greenhouse gas (GHG) mitigation: To achieve the same 73% mitigation as MEA-PCC, HS-DAC would increase nine other environmental impacts by on average 38%, whereas MEA-PCC would increase them by 31%. Powering distributed HS-DAC with photovoltaics (instead of coal) while including recapture of all background GHG, reduces this increase to 18%, hypothetically enabling coal-based electricity with net-zero life-cycle GHG. We conclude that, in suitable geographies, HS-DAC can complement MEA-PCC to enable CO 2 capture independent of time and location of emissions and recapture background GHG from fossil-based electricity beyond flue stack emissions.

  1. Final Report - Advanced MEA's for Enhanced Operating Conditions, Amenable to High Volume Manufacture

    Energy Technology Data Exchange (ETDEWEB)

    Debe, Mark K.

    2007-09-30

    This report summarizes the work completed under a 3M/DOE contract directed at advancing the key fuel cell (FC) components most critical for overcoming the polymer electrolyte membrane fuel cell (PEMFC) performance, durability & cost barriers. This contract focused on the development of advanced ion exchange membranes & electrocatalysts for PEMFCs that will enable operation under ever more demanding automotive operating conditions & the use high volume compatible processes for their manufacture. Higher performing & more durable electrocatalysts must be developed for PEMFCs to meet the power density & lifetime hours required for FC vehicles. At the same time the amount of expensive Pt catalyst must be reduced to lower the MEA costs. While these two properties are met, the catalyst must be made resistant to multiple degradation mechanisms to reach necessary operating lifetimes. In this report, we present the work focused on the development of a completely new approach to PEMFC electrocatalyts, called nanostructured thin film (NSTF) catalysts. The carbon black supports are eliminated with this new approach which eliminates the carbon corrosion issue. The thin film nature of the catalyst significantly improves its robustness against dissolution & grain growth, preserving the surface area. Also, the activity of the NSTF for oxygen reduction is improved by over 500% compared to dispersed Pt catalyts. Finally, the process for fabricating the NSTF catalysts is consistent with high volume roll-good manufacturing & extremely flexible towards the introduction of new catalyst compositions & structures. This report documents the work done to develop new multi-element NSTF catalysts with properties that exceed pure Pt, that are optimized for use with the membranes discussed below, & advance the state-of-the-art towards meeting the DOE 2010 targets for PEMFC electrocatalysts. The work completed advances the understanding of the NSTF catalyst technology, identifies new NSTF

  2. Simultaneous removal of CO2 and H2S using MEA solution in a packed column absorber for biogas upgrading

    Directory of Open Access Journals (Sweden)

    Preecha Kasikamphaiboon

    2013-12-01

    Full Text Available Biogas production and utilization is an emerging alternative energy technology that has gained importance since the price of oil and gas has increased steadily over the last two decades. Biogas primarily consists of methane (CH4 and carbon dioxide (CO2 with smaller amounts of hydrogen sulfide (H2S and ammonia (NH3. For many applications the quality of biogas has to be improved. The main parameters that may require removal in upgrading systems are CO2 and H2S. This work presents the study of simultaneous absorption of CO2 and H2S by Monoethanolamine (MEA solution in a packed column. Simulated biogas containing 40% CO2 and 60% N2 and biogas generated from an anaerobic digestion plant were used as feed gas streams. The effects of gas flow rate, L/G ratio and absorbent concentration were investigated. The performance of the system was found to vary with process parameters. Increasing L/G ratio and MEA concentration causes the system efficiency to increase whereas increasing gas flow rate results in lower efficiency. An operating condition of L/G ratio of 83.3 ml/L, gas flow rate of 3 L/min and MEA concentration of 3 mol/L was found to remove more than 99.5% of CO2 and H2S from biogas. The volumetric overall mass-transfer coefficient (KGav for CO2 removal initially increases with increasing gas flow rate up to a certain value beyond which the coefficient becomes essentially constant. The KGav also increases with increasing L/G ratio throughout the range tested in this study.

  3. A new pilot absorber for CO2 capture from flue gases: Measuring and modelling capture with MEA solution

    DEFF Research Database (Denmark)

    Sønderby, Tim L.; Carlsen, Kim B.; Fosbøl, Philip Loldrup

    2013-01-01

    A pilot absorber column for CO2 recovery from flue gases was constructed and tested with aqueous 30wt% monoethanolamine (MEA), a primary amine, as capture solvent. The pilot plant data were compared with a mathematical rate based packed-column model. The simulation results compared well...... with the pilot plant data. The packed height of the column can be varied from 1.6 to 8.2. m by means of five different liquid inlets. The column has an inner diameter of 100. mm and is packed with structured Mellapak 250Y packing. Counter-current flow is used. The pilot plant performance was investigated...

  4. Mutagenic potency of MMS-induced 1meA/3meC lesions in E. coli.

    Science.gov (United States)

    Nieminuszczy, Jadwiga; Mielecki, Damian; Sikora, Anna; Wrzesiński, Michał; Chojnacka, Aleksandra; Krwawicz, Joanna; Janion, Celina; Grzesiuk, Elzbieta

    2009-12-01

    The mutagenic activity of MMS in E. coli depends on the susceptibility of DNA bases to methylation and their repair by cellular defense systems. Among the lesions in methylated DNA is 1meA/3meC, which is recently recognized as being mutagenic. In this report, special attention is focused on the mutagenic properties of 1meA/3meC which, by the activity of AlkB-dioxygenase, are quickly and efficiently converted to natural A/C bases in the DNA of E. coli alkB(+) strains, preventing 1meA/3meC-induced mutations. We have found that in the absence of AlkB-mediated repair, MMS treatment results in an increased frequency of four types of base substitutions: GC-->CG, GC-->TA, AT-->CG, and AT-->TA, whereas overproduction of PolV in CC101-106 alkB(-)/pRW134 strains leads to a markedly elevated level of GC-->TA, GC-->CG, and AT-->TA transversions. It has been observed that in the case of AB1157 alkB(-) strains, the MMS-induced and 1meA/3meC-dependent argE3-->Arg(+) reversion occurs efficiently, whereas lacZ(-)--> Lac(+) reversion in a set of CC101-106 alkB(-) strains occurs with much lower frequency. We considered several reasons for this discrepancy, namely, the possible variance in the level of the PolV activity, the effect of the PolIV contents that is higher in CC101-106 than in AB1157 strains and the different genetic cell backgrounds in CC101-106 alkB(-) and AB1157 alkB(-) strains, respectively. We postulate that the difference in the number of targets undergoing mutation and different reactivity of MMS with ssDNA and dsDNA are responsible for the high (argE3-->Arg(+)) and low (lacZ(-) --> Lac(+)) frequency of MMS-induced mutations.

  5. Modeling MEA with the CPA equation of state: A parameter estimation study adding local search to PSO algorithm

    DEFF Research Database (Denmark)

    Santos, Letícia Cotia dos; Tavares, Frederico Wanderley; Ahón, Victor Rolando Ruiz

    2015-01-01

    parameters for MEA. This work proposes adding LLE information systematically in the CPA parameter estimation procedure. At first, the parameter search space is defined by the results from the PSO sensitivity analysis for VLE considering the experimental error for vapor pressures and liquid densities...... (objective function cut off). Then, two possible methodologies are discussed: the first one uses all the possible parameter sets and check them against the LLE and VLE experimental data. The second method explicitly incorporates LLE information into the objective function and uses both PSO and PSO...

  6. NeuroMap: A spline-based interactive open-source software for spatiotemporal mapping of 2D and 3D MEA data

    Directory of Open Access Journals (Sweden)

    Oussama eAbdoun

    2011-01-01

    Full Text Available A major characteristic of neural networks is the complexity of their organization at various spatial scales, from microscopic local circuits to macroscopic brain-scale areas. Understanding how neural information is processed thus entails the ability to study them at multiple scales simultaneously. This is made possible using microelectrodes array (MEA technology. Indeed, high-density MEAs provide large-scale covering (several mm² of whole neural structures combined with microscopic resolution (about 50µm of unit activity. Yet, current options for spatiotemporal representation of MEA-collected data remain limited. Here we present NeuroMap, a new interactive Matlab-based software for spatiotemporal mapping of MEA data. NeuroMap uses thin plate spline interpolation, which provides several assets with respect to conventional mapping methods used currently. First, any MEA design can be considered, including 2D or 3D, regular or irregular, arrangements of electrodes. Second, spline interpolation allows the estimation of activity across the tissue with local extrema not necessarily at recording sites. Finally, this interpolation approach provides a straightforward analytical estimation of the spatial Laplacian for better current sources localization. In this software, coregistration of 2D MEA data on the anatomy of the neural tissue is made possible by fine matching of anatomical data with electrode positions using rigid deformation based correction of anatomical pictures. Overall, NeuroMap provides substantial material for detailed spatiotemporal analysis of MEA data. The package is distributed under GNU General Public License (GPL and available at http://sites.google.com/site/neuromapsoftware.

  7. NeuroMap: A Spline-Based Interactive Open-Source Software for Spatiotemporal Mapping of 2D and 3D MEA Data.

    Science.gov (United States)

    Abdoun, Oussama; Joucla, Sébastien; Mazzocco, Claire; Yvert, Blaise

    2011-01-01

    A major characteristic of neural networks is the complexity of their organization at various spatial scales, from microscopic local circuits to macroscopic brain-scale areas. Understanding how neural information is processed thus entails the ability to study them at multiple scales simultaneously. This is made possible using microelectrodes array (MEA) technology. Indeed, high-density MEAs provide large-scale coverage (several square millimeters) of whole neural structures combined with microscopic resolution (about 50 μm) of unit activity. Yet, current options for spatiotemporal representation of MEA-collected data remain limited. Here we present NeuroMap, a new interactive Matlab-based software for spatiotemporal mapping of MEA data. NeuroMap uses thin plate spline interpolation, which provides several assets with respect to conventional mapping methods used currently. First, any MEA design can be considered, including 2D or 3D, regular or irregular, arrangements of electrodes. Second, spline interpolation allows the estimation of activity across the tissue with local extrema not necessarily at recording sites. Finally, this interpolation approach provides a straightforward analytical estimation of the spatial Laplacian for better current sources localization. In this software, coregistration of 2D MEA data on the anatomy of the neural tissue is made possible by fine matching of anatomical data with electrode positions using rigid-deformation-based correction of anatomical pictures. Overall, NeuroMap provides substantial material for detailed spatiotemporal analysis of MEA data. The package is distributed under GNU General Public License and available at http://sites.google.com/site/neuromapsoftware.

  8. Interaction and transport of cysteamine (MEA) through membrane models. {sup 15}N-NMR et {sup 1}H-NMR; Interaction et transport de la cysteamine (MEA) a travers des membranes modeles. Etude par {sup 15}N-RMN et {sup 1}H-RMN

    Energy Technology Data Exchange (ETDEWEB)

    Lagoueyte, C.; Subra, G.; Bonnet, P.A.; Chapat, J.P.; Debouzy, J.C.; Fauvelle, F.; Berleur, F.; Roman, V.; Fatome, M.; Fernandez, J.P.

    1995-12-31

    We investigated by {sup 15}N-NMR the interactions of [{sup 15}N]-MEA, a radio-protecting aminothiol, with model membranes (SUVs and LUVs) of egg yolk phosphatidylcholine and phosphatidic acid. We prepared LUVs with a pH gradient between the intravesicular space and the bulk medium. Even though the external pH was low, MEA penetrates into the vesicles. With SUVs, {sup 1}H-NMR revealed that the interactions of unlabeled MEA within the hydrophobic core of the bilayer vary with external pH value. (author). 5 refs.

  9. Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs).

    Science.gov (United States)

    Sala, Luca; Ward-van Oostwaard, Dorien; Tertoolen, Leon G J; Mummery, Christine L; Bellin, Milena

    2017-05-12

    Cardiomyocytes can now be derived with high efficiency from both human embryonic and human induced-Pluripotent Stem Cells (hPSC). hPSC-derived cardiomyocytes (hPSC-CMs) are increasingly recognized as having great value for modeling cardiovascular diseases in humans, especially arrhythmia syndromes. They have also demonstrated relevance as in vitro systems for predicting drug responses, which makes them potentially useful for drug-screening and discovery, safety pharmacology and perhaps eventually for personalized medicine. This would be facilitated by deriving hPSC-CMs from patients or susceptible individuals as hiPSCs. For all applications, however, precise measurement and analysis of hPSC-CM electrical properties are essential for identifying changes due to cardiac ion channel mutations and/or drugs that target ion channels and can cause sudden cardiac death. Compared with manual patch-clamp, multi-electrode array (MEA) devices offer the advantage of allowing medium- to high-throughput recordings. This protocol describes how to dissociate 2D cell cultures of hPSC-CMs to small aggregates and single cells and plate them on MEAs to record their spontaneous electrical activity as field potential. Methods for analyzing the recorded data to extract specific parameters, such as the QT and the RR intervals, are also described here. Changes in these parameters would be expected in hPSC-CMs carrying mutations responsible for cardiac arrhythmias and following addition of specific drugs, allowing detection of those that carry a cardiotoxic risk.

  10. Enhanced MEA Performance for PEMFCs under Low Relative Humidity and Low Oxygen Content Conditions via Catalyst Functionalization

    Energy Technology Data Exchange (ETDEWEB)

    Xin, Le; Yang, Fan; Xie, Jian; Yang, Zhiwei; Kariuki, Nancy N.; Myers, Deborah J.; Peng, Jui-Kun; Wang, Xiaohua; Ahluwalia, Rajesh K.; Yu, Kang; Ferreira, Paulo J.; Bonastre, Alex Martinez; Fongalland, Dash; Sharman, Jonathan

    2017-01-01

    This work demonstrates that functionalizing annealed-Pt/Ketjen black EC300j (a-Pt/KB) and dealloyed-PtNi/Ketjen black EC300j (d-PtNi/KB) catalysts using p-phenyl sulfonic acid can effectively enhance performance in the membrane electrode assemblies (MEAs) of proton exchange membrane fuel cells (PEMFCs). The functionalization increased the size of both Pt and PtNi catalyst particles and resulted in the further leaching of Ni from the PtNi catalyst while promoting the formation of nanoporous PtNi nanoparticles. The size of the SO3H-Pt/KB and SO3H-PtNi/KB carbon-based aggregates decreased dramatically, leading to the formation of catalyst layers with narrower pore size distributions.MEA tests highlighted the benefits of the surface functionalization, in which the cells with SO3H-Pt/KB and SO3H-PtNi/KB cathode catalysts showed superior high current density performance under reduced RH conditions, in comparison with cells containing annealed Pt/KB (a-Pt/KB) and de-alloyed PtNi/KB (d-PtNi/KB) catalysts. The performance improvement was particularly evident when using reactant gases with low relative humidity, indicating that the hydrophilic functional groups on the carbon improved the water retention in the cathode catalyst layer. These results show a new avenue for enhancing catalyst performance for the next generation of catalytic materials for PEMFCs.

  11. Elimination of voltage reversal in multiple membrane electrode assembly installed microbial fuel cells (mMEA-MFCs) stacking system by resistor control.

    Science.gov (United States)

    Kim, Bongkyu; Chang, In Seop

    2018-08-01

    Voltage reversal (VR) in series connection of multiple membrane electrode assembly installed microbial fuel cells (mMEA-MFC) is eliminated by manipulating the resistor control. Discharge test results collected from two mMEA-MFCs initially operated (designated as P1 and P2) confirm that the performance of P2 exceeds that of P1. Thus, driving P1 and P2 as serially stacked MFCs generate the VR in P1. Controlling the inserted resistor adjust the current production of P2 to maintain balance with P1, and the VR in P1 is eliminated in the operation of stacking mode. Thus, manipulating the internal resistance provide an applicable approach to suppress VR in the stacking of mMEA-MFCs system. Copyright © 2018 Elsevier Ltd. All rights reserved.

  12. Analysis for impedance electrochemistry 'on-line' of membrane/electrode assemble (MEA) of protons exchange membrane fuel cells (PEMFC); Analise por impedancia eletroquimica 'on-line' de conjuntos eletrodos/membrana (MEA) de celulas a combustivel a membrana polimetrica (PEMFC)

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Antonio Rodolfo dos

    2007-07-01

    This work reports results of studies and characterization on membrane electrode assemblies (MEAs) for proton exchange membrane fuel cell (PEMFC). Some cell operation conditions and different processes of MEA production were investigated. The electrochemical impedance spectroscopy technique (EIS) (in situ - 0 to 16 A) was used 'on-line' as a tool for diagnosis, concerning the cell performance. The EIS measurements were carried out with a FC350 Fuel Cell EIS System (GAMRY), coupled to a PC4 potentiostat/galvanostat and connected to the electronic load (TDI) for 'on-line' EIS experiments (100 mHz - 10 kHz, dU = 5 mV). MEAs with 25 cm{sup 2} surface area, using PtM/C 20% (M Ru, Sn or Ni) electrocatalysts were manufactured using the alcohol reduction process (ARP). The catalytic ink was applied directly into the carbon cloth (GDL) and pressed in the Nafion membrane (105). MEAs using Pt/C and Pt Ru/C 20% from E-TEK electrocatalysts were manufactured by comparison. All the cathodes were sprayed with Pt/C 20% from E-TEK. The noble metal concentrations used were set to 0.4 mg Pt.cm{sup -2} at the anode and 0.6 mg Pt.cm{sup -2} at the cathode (E-TEK). Nyquist diagrams of the MEAs with Pt/C and PtRu/C from E-TEK or PtM/C (M = Ru, Sn or Ni) ARP showed essentially the same ohmic resistances for the MEAs. This fact can be explained by suppression of agglomerates during the MEA preparation process or by the homogeneity of the anchored electrocatalysts at the carbon surface. It could also be observed, at low current densities, that there was a significant performance difference between the electrocatalysts from E-TEK and those prepared with the alcohol reduction process. The polarization curves results confirmed that the Pt M/C (M = Ru, Sn or Ni) ARP showed an activity increase for the methanol and ethanol fed cells. The technique of EIE was shown efficient for the evaluation of the method preparation of MEAs and the acting of the cell, the results of EIE

  13. Analysis for impedance electrochemistry 'on-line' of membrane/electrode assemble (MEA) of protons exchange membrane fuel cells (PEMFC); Analise por impedancia eletroquimica 'on-line' de conjuntos eletrodos/membrana (MEA) de celulas a combustivel a membrana polimetrica (PEMFC)

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Antonio Rodolfo dos

    2007-07-01

    This work reports results of studies and characterization on membrane electrode assemblies (MEAs) for proton exchange membrane fuel cell (PEMFC). Some cell operation conditions and different processes of MEA production were investigated. The electrochemical impedance spectroscopy technique (EIS) (in situ - 0 to 16 A) was used 'on-line' as a tool for diagnosis, concerning the cell performance. The EIS measurements were carried out with a FC350 Fuel Cell EIS System (GAMRY), coupled to a PC4 potentiostat/galvanostat and connected to the electronic load (TDI) for 'on-line' EIS experiments (100 mHz - 10 kHz, dU = 5 mV). MEAs with 25 cm{sup 2} surface area, using PtM/C 20% (M Ru, Sn or Ni) electrocatalysts were manufactured using the alcohol reduction process (ARP). The catalytic ink was applied directly into the carbon cloth (GDL) and pressed in the Nafion membrane (105). MEAs using Pt/C and Pt Ru/C 20% from E-TEK electrocatalysts were manufactured by comparison. All the cathodes were sprayed with Pt/C 20% from E-TEK. The noble metal concentrations used were set to 0.4 mg Pt.cm{sup -2} at the anode and 0.6 mg Pt.cm{sup -2} at the cathode (E-TEK). Nyquist diagrams of the MEAs with Pt/C and PtRu/C from E-TEK or PtM/C (M = Ru, Sn or Ni) ARP showed essentially the same ohmic resistances for the MEAs. This fact can be explained by suppression of agglomerates during the MEA preparation process or by the homogeneity of the anchored electrocatalysts at the carbon surface. It could also be observed, at low current densities, that there was a significant performance difference between the electrocatalysts from E-TEK and those prepared with the alcohol reduction process. The polarization curves results confirmed that the Pt M/C (M = Ru, Sn or Ni) ARP showed an activity increase for the methanol and ethanol fed cells. The technique of EIE was shown efficient for the evaluation of the method preparation of MEAs and the acting of the cell, the results of EIE showed coherence in the

  14. CO2 absorption into aqueous amine blended solutions containing monoethanolamine (MEA), N,N-dimethylethanolamine (DMEA), N,N-diethylethanolamine (DEEA) and 2-amino-2-methyl-1-propanol (AMP) for post-combustion capture processes

    NARCIS (Netherlands)

    Conway, William; Bruggink, Stefan; Beyad, Yaser; Luo, Weiliang; Melian-Cabrera, Ignacio; Puxty, Graeme; Feron, Paul

    2015-01-01

    Presently monoethanolamine (MEA) remains the industrial standard solvent for CO2 capture processes. Operating issues relating to corrosion and degradation of MEA at high temperatures and concentrations, and in the presence of oxygen, in a traditional PCC process, have introduced the requisite for

  15. Comparative Environmental Life Cycle Assessment of Oxyfuel and Post-combustion Capture with MEA and AMP/PZ - Case Studies from the EDDiCCUT Project

    NARCIS (Netherlands)

    Oreggioni, Gabriel D.; Singh, Bhawna; Hung, Christine Roxanne; Van Der Spek, Mijndert W.; Skagestad, Ragnhild; Eldrup, Nils Henrik; Ramirez, Andrea; Strømman, Anders Hammer

    2017-01-01

    This work presents the results of a comparative life cycle assessment study for three CCS technologies applied to a coal-fired power plant: post-combustion capture with MEA, post combustion capture with AMP/PZ and cryogenic oxy-fuel. This study has been performed in the context of the EDDiCCUT

  16. Agreement Between the Board of Control of Ferris State College, Big Rapids, Michigan and The Ferris Faculty Association - MEA-NEA 1973-75.

    Science.gov (United States)

    Ferris State Coll., Big Rapids, MI.

    This agreement between the Board of Control of Ferris State College and the Ferris Faculty Association--MEA-NEA covers the period 1973-75. Sections of the agreement cover the basic contractual provisions, rights of the association, faculty rights, administrative responsibilities, promotions and transfers, teaching conditions, retrenchment,…

  17. A Nitrogen Response Pathway Regulates Virulence Functions in Fusarium oxysporum via the Protein Kinase TOR and the bZIP Protein MeaB[C][W

    Science.gov (United States)

    López-Berges, Manuel S.; Rispail, Nicolas; Prados-Rosales, Rafael C.; Di Pietro, Antonio

    2010-01-01

    During infection, fungal pathogens activate virulence mechanisms, such as host adhesion, penetration and invasive growth. In the vascular wilt fungus Fusarium oxysporum, the mitogen-activated protein kinase Fmk1 is required for plant infection and controls processes such as cellophane penetration, vegetative hyphal fusion, or root adhesion. Here, we show that these virulence-related functions are repressed by the preferred nitrogen source ammonium and restored by treatment with l-methionine sulfoximine or rapamycin, two specific inhibitors of Gln synthetase and the protein kinase TOR, respectively. Deletion of the bZIP protein MeaB also resulted in nitrogen source–independent activation of virulence mechanisms. Activation of these functions did not require the global nitrogen regulator AreA, suggesting that MeaB-mediated repression of virulence functions does not act through inhibition of AreA. Tomato plants (Solanum lycopersicum) supplied with ammonium rather than nitrate showed a significant reduction in vascular wilt symptoms when infected with the wild type but not with the ΔmeaB strain. Nitrogen source also affected invasive growth in the rice blast fungus Magnaporthe oryzae and the wheat head blight pathogen Fusarium graminearum. We propose that a conserved nitrogen-responsive pathway might operate via TOR and MeaB to control virulence in plant pathogenic fungi. PMID:20639450

  18. Utilizing Model Eliciting Activities (MEA's) to engage middle school teachers and students in storm water management practices to mitigate human impacts of land development

    Science.gov (United States)

    Tazaz, A.; Wilson, R. M.; Schoen, R.; Blumsack, S.; King, L.; Dyehouse, M.

    2013-12-01

    'The Integrating STEM Project' engaged 6-8 grade teachers through activities incorporating mathematics, science and technology incorporating both Next Generation Science Standards (NGSS) and Common Core State Standards-Mathematics (CCSS-Math). A group of researchers from Oceanography, Mathematics, and Education set out to provide middle school teachers with a 2 year intensive STEM integration professional development with a focus on environmental topics and to monitor the achievement outcomes in their students. Over the course of 2 years the researchers created challenging professional development sessions to expand teacher knowledge and teachers were tasked to transform the information gained during the professional development sessions for classroom use. One lesson resource kit presented to the teachers, which was directly applicable to the classroom, included Model Eliciting Activities (MEA's) to explore the positive and negative effects land development has on climate and the environment, and how land development impacts storm water management. MEA's were developed to encourage students to create models to solve complex problems and to allow teachers to investigate students thinking. MEA's are a great curriculum technique used in engineering fields to help engage students by providing hands on activities using real world data and problems. We wish to present the Storm Water Management Resource toolkit including the MEA and present the outcomes observed from student engagement in this activity.

  19. PENGAWASAN, EVALUASI, DAN PENILAIAN SISTEM PENGENDALIAN INTERNAL TERKAIT BILLING SYSTEM PADA RSUD UNGARAN BERDASARKAN KERANGKA KERJA COBIT 5 (MEA02

    Directory of Open Access Journals (Sweden)

    Marthania Firmadita

    2016-10-01

    Full Text Available RSUD Ungaran Kabupaten Semarang ini memiliki sejumlah layanan kesehatan yang melayani masyarakat umum, layanan kesehatan dinamakan dengan Billing System yang dibuat dengan tujuan mempercepat pelayanan kesehatan terhadap pelanggan. Melihat banyaknya kebutuhan setiap bagian yang terkait sehingga semakin besar pengelolaan data yang ada menyebabkan keterlambatan sistem dan kesalahan dalam pengelolaan data. Berbagai upaya dilakukan untuk memberikan layanan operasional terbaik dan meminimalisasi kesalahan. Salah satunya dilakukan penilaian kinerja pengelolaan layanan yang diberikan, penilaian kinerja ini merupakan pengendalian kontrol internal secara sistematik, untuk melihat tingkat kesesuaian dan keefektifan implementasi layanan. Dari hasil observasi, wawancara, dan kuesioner berdasarkan COBIT 5 dihasilkan level kapabilitas tata kelola proses pengawasan, evaluasi, dan penilaian pengendalian internal terkait billing system (MEA02 pada RSUD Ungaran saat ini adalah Level 2 dengan status Largely Achieved sebesar 71,56% setara 2,71 dimana Level 1 dan Level 0 tercapai Fully Achieved.Hal ini menunjukan sudah dilakukan komunikasi perencanaan kedepan dari hasil penilaian kinerja tetapi belum diimplementasikan. Dan untuk mencapai level kapabilitas, RSUD Ungaran dapat melakukan strategi perbaikan yang dilakukan secara bertahap dari proses atribut level 1 sampai 3. Kata Kunci: Analisis Tata Kelola TI, Sistem Informasi Kesehatan, COBIT 5, Analisis Tingkat Kapabilitas, Analisis Kesenjangan

  20. Modification of MEA modulator-klystron units enabling short pulse injection into a pulse-stretcher ring

    International Nuclear Information System (INIS)

    Kroes, F.B.; Heine, E.

    1989-01-01

    In order to modify the present 500 MeV, 1% duty factor electron accelerator MEA into a 900 MeV, 0.1% d.f. injector for a newly to be build pulse- stretching ring, the present modulator-klystron units have to be adapted from 4 MW, 2% d.f. mode of operation into the 10 MW, 0.2% d.f. mode. Suitable klystrons are commercially available, the matching modulators, however, will be obtained by modifying the present ones, which policy is dictated by economical considerations. The design principles of these modulators -a proto-type is presently under construction- will be discussed. Special attention is given to the video-pulse shape requirements, dictated by the future performance of the pulse-stretcher. This device has to deliver low emittance, high duty factor (n90%) beams for nuclear physics experiments. Some proto-type tests of the video-pulse forming modifications will be presented. (author). 5 refs.; 11 figs.; 2 tabs

  1. NÃveis de isoleucina digestÃvel sobre o desempenho de fÃmeas suÃnas dos 15 aos 30 kg

    OpenAIRE

    Leandro Dalcin Castilha

    2011-01-01

    Com o objetivo de determinar a exigÃncia de isoleucina digestÃvel para fÃmeas suÃnas dos 15 aos 30 kg, foram realizados dois experimentos, um ensaio de desempenho e um balanÃo do nitrogÃnio. No primeiro experimento, foram utilizadas 40 fÃmeas suÃnas, mestiÃas, de alto potencial genÃtico e desempenho mÃdio, com peso vivo inicial de 15,00 Â 0,52kg, distribuÃdas em um delineamento experimental de blocos ao acaso, constituÃdo de cinco tratamentos (0,45; 0,52; 0,59; 0,66; 0,73% de isoleucina diges...

  2. Design, economics and parameter uncertainty in dynamic operation of post-combustion CO2 capture using piperazine (PZ) and MEA

    DEFF Research Database (Denmark)

    Gaspar, Jozsef; Ricardez-Sandoval, Luis; Jørgensen, John Bagterp

    2017-01-01

    of the plant. Flexibility is particularly crucial from an economic and operational point of view since plants must balance the power production and the electricity demand on a daily basis. This work shows the impact of design decisions and uncertainties on the dynamic operation and economics of a CO2 capture...... plant using piperazine (PZ), compared to the benchmark MEA solvent. This is exemplified through dynamic model calculations. The results show that the capacity of the buffer tank is a key parameter for the flexibility of the plant. A small tank corresponds to lower capital cost but it leads to increased...... operation cost and also to flexibility/controllability issues. Both, the PZ and MEA plants present inverse response for small tanks. These plants are challenging to control....

  3. Direct Determination of the Rate Coefficient for the Reaction of OH Radicals with Monoethanol Amine (MEA) from 296 to 510 K.

    Science.gov (United States)

    Onel, L; Blitz, M A; Seakins, P W

    2012-04-05

    Monoethanol amine (H2NCH2CH2OH, MEA) has been proposed for large-scale use in carbon capture and storage. We present the first absolute, temperature-dependent determination of the rate coefficient for the reaction of OH with MEA using laser flash photolysis for OH generation, monitoring OH removal by laser-induced fluorescence. The room-temperature rate coefficient is determined to be (7.61 ± 0.76) × 10(-11) cm(3) molecule(-1) s(-1), and the rate coefficient decreases by about 40% by 510 K. The temperature dependence of the rate coefficient is given by k1= (7.73 ± 0.24) × 10(-11)(T/295)(-(0.79±0.11)) cm(3) molecule(-1) s(-1). The high rate coefficient shows that gas-phase processing in the atmosphere will be competitive with uptake onto aerosols.

  4. Making Earth Science Data Records for Use in Research Environments (MEaSUREs) Projects Data and Services at the GES DISC

    Science.gov (United States)

    Vollmer, Bruce E.; Ostrenga, D.; Savtchenko, A.; Johnson, J.; Wei, J.; Teng, W.; Gerasimov, I.

    2011-01-01

    NASA's Earth Science Program is dedicated to advancing Earth remote sensing and pioneering the scientific use of satellite measurements to improve human understanding of our home planet. Through the MEaSUREs Program, NASA is continuing its commitment to expand understanding of the Earth system using consistent data records. Emphasis is on linking together multiple data sources to form coherent time-series, and facilitating the use of extensive data in the development of comprehensive Earth system models. A primary focus of the MEaSUREs Program is the creation of Earth System Data Records (ESDRs). An ESDR is defined as a unified and coherent set of observations of a given parameter of the Earth system, which is optimized to meet specific requirements for addressing science questions. These records are critical for understanding Earth System processes; for the assessment of variability, long-term trends, and change in the Earth System; and for providing input and validation means to modeling efforts. Seven MEaSUREs projects will be archived and distributed through services at the Goddard Earth Sciences Data and Information Services Center (GES DISC).

  5. Experimental investigation on spontaneously active hippocampal cultures recorded by means of high-density MEAs: analysis of the spatial resolution effects

    Directory of Open Access Journals (Sweden)

    Alessandro Maccione

    2010-05-01

    Full Text Available Based on experiments performed with high-resolution Active Pixel Sensor microelectrode arrays (APS-MEAs coupled with spontaneously active hippocampal cultures, this work investigates the spatial resolution effects of the neuroelectronic interface on the analysis of the recorded electrophysiological signals. The adopted methodology consists, first, in recording the spontaneous activity at the highest spatial resolution (inter-electrode separation of 21 µm from the whole array of 4096 microelectrodes. Then, the full resolution dataset is spatially down sampled in order to evaluate the effects on raster plot representation, array-wide spike rate (AWSR, mean firing rate (MFR and mean bursting rate (MBR. Furthermore, the effects of the array-to-network relative position are evaluated by shifting a subset of equally spaced electrodes on the entire recorded area. Results highlight that MFR and MBR are particularly influenced by the spatial resolution provided by the neuroelectronic interface. On high-resolution large MEAs, such analysis better represent the time-based parameterization of the network dynamics. Finally, this work suggest interesting capabilities of high-resolution MEAs for spatial-based analysis in dense and low-dense neuronal preparation for investigating signalling at both local and global neuronal circuitries.

  6. A nitrogen response pathway regulates virulence functions in Fusarium oxysporum via the protein kinase TOR and the bZIP protein MeaB.

    Science.gov (United States)

    López-Berges, Manuel S; Rispail, Nicolas; Prados-Rosales, Rafael C; Di Pietro, Antonio

    2010-07-01

    During infection, fungal pathogens activate virulence mechanisms, such as host adhesion, penetration and invasive growth. In the vascular wilt fungus Fusarium oxysporum, the mitogen-activated protein kinase Fmk1 is required for plant infection and controls processes such as cellophane penetration, vegetative hyphal fusion, or root adhesion. Here, we show that these virulence-related functions are repressed by the preferred nitrogen source ammonium and restored by treatment with l-methionine sulfoximine or rapamycin, two specific inhibitors of Gln synthetase and the protein kinase TOR, respectively. Deletion of the bZIP protein MeaB also resulted in nitrogen source-independent activation of virulence mechanisms. Activation of these functions did not require the global nitrogen regulator AreA, suggesting that MeaB-mediated repression of virulence functions does not act through inhibition of AreA. Tomato plants (Solanum lycopersicum) supplied with ammonium rather than nitrate showed a significant reduction in vascular wilt symptoms when infected with the wild type but not with the DeltameaB strain. Nitrogen source also affected invasive growth in the rice blast fungus Magnaporthe oryzae and the wheat head blight pathogen Fusarium graminearum. We propose that a conserved nitrogen-responsive pathway might operate via TOR and MeaB to control virulence in plant pathogenic fungi.

  7. A nitrogen response pathway regulates virulence in plant pathogenic fungi: role of TOR and the bZIP protein MeaB.

    Science.gov (United States)

    López-Berges, Manuel S; Rispail, Nicolas; Prados-Rosales, Rafael C; Di Pietro, Antonio

    2010-12-01

    Virulence in plant pathogenic fungi is controlled through a variety of cellular pathways in response to the host environment. Nitrogen limitation has been proposed to act as a key signal to trigger the in planta expression of virulence genes. Moreover, a conserved Pathogenicity mitogen activated protein kinase (MAPK) cascade is strictly required for plant infection in a wide range of pathogens. We investigated the relationship between nitrogen signaling and the Pathogenicity MAPK cascade in controlling infectious growth of the vascular wilt fungus Fusarium oxysporum. Several MAPK-activated virulence functions such as invasive growth, vegetative hyphal fusion and host adhesion were strongly repressed in the presence of the preferred nitrogen source ammonium. Repression of these functions by ammonium was abolished by L-Methionine sulfoximine (MSX) or rapamycin, two specific inhibitors of Gln synthetase and the protein kinase TOR (Target Of Rapamycin), respectively, and was dependent on the bZIP protein MeaB. Supplying tomato plants with ammonium rather than nitrate resulted in a significant delay of vascular wilt symptoms caused by the F. oxysporum wild type strain, but not by the ΔmeaB mutant. Ammonium also repressed invasive growth in two other pathogens, the rice blast fungus Magnaporthe oryzae and the wheat head blight pathogen Fusarium graminearum. Our results suggest the presence of a conserved nitrogen-responsive pathway that operates via TOR and MeaB to control infectious growth in plant pathogenic fungi.

  8. Identification of metabolites in urine and feces from rats dosed with the heterocyclic amine, 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA alpha C)

    DEFF Research Database (Denmark)

    Frederiksen, H; Frandsen, H

    2004-01-01

    2-Amino-3-methyl-9H-pyrido[2,3-b]indole (MeA alpha C) is a proximate mutagenic and carcinogenic heterocyclic amine formed during ordinary cooking. In model systems, MeA alpha C can be formed by pyrolyses of either tryptophan or proteins of animal or vegetable origin. In the present study, the in ......2-Amino-3-methyl-9H-pyrido[2,3-b]indole (MeA alpha C) is a proximate mutagenic and carcinogenic heterocyclic amine formed during ordinary cooking. In model systems, MeA alpha C can be formed by pyrolyses of either tryptophan or proteins of animal or vegetable origin. In the present study...

  9. ANALISIS IT GOVERNANCE DENGAN DOMAIN MEA01 DALAM PELAKSANAAN E-HEALTH MENGGUNAKAN KERANGKA KERJA COBIT 5 PADA DINAS KESEHATAN PROVINSI JAWA TENGAH

    Directory of Open Access Journals (Sweden)

    Rusyida Baniya Savira

    2016-03-01

    Full Text Available Teknologi Informasi memiliki peran yang sangat penting untuk mendukung tujuan pencapaian suatu kegiatan dalam organisasi mupun instansi. Apabila pemanfaatan TI sudah berjalan dan mampu berintegrasi dengan baik dengan organisasi, maka TI mampu mendorong terjadinya peningkatan kinerja organisasi. Untuk mendukungnya, dibutuhkan suatu kegiatan monitoring, evaluasi, dan penilaian kinerja suatu organisasi. Dinas Kesehatan Provinsi Jawa Tengah merupakan suatu instansi pemerintahan yang bertindak sebagai penyelenggara untuk penyediaan layanan kesehatan kepada masyarakat di daerah Jawa Tengah. Permasalahan yang pada Dinas Kesehatan Provinsi Jawa Tengah adalah dalam pelaksanaan kegiatan pengawasan dan evaluasi masih ditemukan beberapa kekurangan seperti kurang lengkapnya Standart Operational Procedure (SOP mengenai detail proses pengawasan dan penilaian kinerja, proses tata kelola TI yang belum dilakukan secara menyeluruh, serta kurangnya pengawasan dalam peningkatan kebutuhan pemakaian e-health. Dari hasil studi dokumen, wawancara dan kuesioner berdasarkan COBIT 5 dihasilkan level kapabilitas tata kelola proses monitoring, evaluasi, dan penilaian kinerja dan kesesuaian (MEA01 saat ini adalah level 1 yaitu Performed, dengan tingkat pencapaian Largely Achieved sebesar 83,33% atau setara dengan 1,83 yang menunjukkan bahwa proses monitoring kinerja dan kesesuaian yang telah diimplementasikan berhasil mencapai tujuan instansi tetapi masih belum sepenuhnya dikelola dengan baik. Untuk mencapai level kapabilitas 2, dapat dilakukan strategi perbaikan secara bertahap dari proses atribut level 1 sampai 2. Kata kunci: COBIT 5, Analisis Tata Kelola TI, E-health, Proses Monitoring Evaluate and Assess Performance and Conformance (MEA01, Dinas Kesehatan Provinsi Jawa Tengah.

  10. Techno-economic study of CO2 capture from an existing coal-fired power plant: MEA scrubbing vs. O2/CO2 recycle combustion

    International Nuclear Information System (INIS)

    Singh, D.; Croiset, E.; Douglas, P.L.; Douglas, M.A.

    2003-01-01

    The existing fleet of modern pulverised coal fired power plants represents an opportunity to achieve significant reductions in greenhouse gas emissions in the coming years providing that efficient and economical CO 2 capture technologies are available for retrofit. One option is to separate CO 2 from the products of combustion using conventional approaches such as amine scrubbing. An emerging alternative, commonly known as O 2 /CO 2 recycle combustion, involves burning the coal with oxygen in an atmosphere of recycled flue gas. Both approaches can be retrofitted to existing units, however they consume significant amounts of energy to capture, purify and compress the CO 2 for subsequent sequestration. This paper presents a techno-economic comparison of the performance of the two approaches. The comparison was developed using the commercial process simulation packages, Hysys and Aspen Plus. The results show that both processes are expensive options to capture CO 2 from coal power plants, however O 2 /CO 2 appears to be a more attractive retrofit than MEA scrubbing. The CO 2 capture cost for the MEA case is USD 53/ton of CO 2 avoided, which translates into 3.3 cents/kW h. For the O 2 /CO 2 case the CO 2 capture cost is lower at USD 35/ton of CO 2 avoided, which translates into 2.4 cents/kW h. These capture costs represent an approximate increase of 20-30% in current electricity prices

  11. Comparison study Of H2O determination in UO2 powder by using MEA (Moisture Evaluation Analysis) and KFT (Karl Fischer Titration)

    International Nuclear Information System (INIS)

    Farida; Yudhi, N.; Lilis, W.; Putro, P.K.

    2000-01-01

    To find out an analytical method to determine H 2 O content in UO 2 powder as fuel elements of power reactors which is simple, economical, precise, and accurate, it is necessary to do comparison study of H 2 O content determination using MEA method which is based on electrolysis process with two helically wound electrodes which contains P 2 O 5 that has function to absorb water steam. The platinum electrodes have a 67 Volt potential on them. The quantity of charge required to electrolyse 0.1 μgr of H 2 O is a constant which is the basic of the electronic measurement. In KFT method is based on volumetric titration using the one component reagent hydronol composite contain all reactants i.e. iodine, sulfur dioxide and imidazole as the base, dissolved in a suitable alcohol. The t- (student) test show that there is no different result significantly between those method. The H 2 O contain obtained is 0.956±0.0095 %, for MEA method and 0.953±0.023 % for KFT method. (author)

  12. The use of microelectrode array (MEA) to study the protective effects of potassium channel openers on metabolically compromised HL-1 cardiomyocytes

    International Nuclear Information System (INIS)

    Law, J K Y; Chan, M; Yeung, C K; Rudd, J A; Hofmann, B; Ingebrandt, S; Offenhäusser, A

    2009-01-01

    The microelectrode array (MEA) was used to evaluate the cardioprotective effects of adenosine triphosphate sensitive potassium (K ATP ) channel activation using potassium channel openers (KCOs) on HL-1 cardiomyocytes subjected to acute chemically induced metabolic inhibition. Beat frequency and extracellular action potential (exAP) amplitude were measured in the presence of metabolic inhibitors (sodium azide (NaN 3 ) or 2-deoxyglucose (2-DG)) or KCOs (pinacidil (PIN, a cyanoguanidine derivative, activates sarcolemmal K ATP channels) or SDZ PCO400 (SDZ, a benzopyran derivative, activates mitochondrial K ATP channels)). The protective effects of these KCOs on metabolically inhibited HL-1 cells were subsequently investigated. Signal shapes indicated that NaN 3 and 2-DG reduced the rate of the sodium (Na + ) influx signal as reflected by a reduction in beat frequency. PIN and SDZ appeared to reduce both rate of depolarization and extent of the Na + influx signals. Pre-treating cardiomyocytes with PIN (0.1 mM), but not SDZ, prevented the reduction of beat frequency associated with NaN 3 - or 2-DG-induced metabolic inhibition. The exAP amplitude was not affected by either KCO. The cardioprotective effect of PIN relative to SDZ may be due to the opening of different K ATP channels. This metabolic inhibition model on the MEA may provide a stable platform for the study of cardiac pathophysiology in the future

  13. Evaluation of handling and reuse approaches for the waste generated from MEA-based CO2 capture with the consideration of regulations in the UAE.

    Science.gov (United States)

    Nurrokhmah, Laila; Mezher, Toufic; Abu-Zahra, Mohammad R M

    2013-01-01

    A waste slip-stream is generated from the reclaiming process of monoethanolamine (MEA) based Post-Combustion Capture (PCC). It mainly consists of MEA itself, ammonium, heat-stable salts (HSS), carbamate polymers, and water. In this study, the waste quantity and nature are characterized for Fluor's Econamine FGSM coal-fired CO2 capture base case. Waste management options, including reuse, recycling, treatment, and disposal, are investigated due to the need for a more environmentally sound handling. Regulations, economic potential, and associated costs are also evaluated. The technical, economic, and regulation assessment suggests waste reuse for NOx scrubbing. Moreover, a high thermal condition is deemed as an effective technique for waste destruction, leading to considerations of waste recycling into a coal burner or incineration. As a means of treatment, three secondary-biological processes covering Complete-Mix Activated Sludge (CMAS), oxidation ditch, and trickling filter are designed to meet the wastewater standards in the United Arab Emirates (UAE). From the economic point of view, the value of waste as a NOx scrubbing agent is 6,561,600-7,348,992 USD/year. The secondary-biological treatment cost is 0.017-0.02 USD/ton of CO2, while the cost of an on-site incinerator is 0.031 USD/ton of CO2 captured. In conclusion, secondary biological treatment is found to be the most economical option.

  14. Action potential-based MEA platform for in vitro screening of drug-induced cardiotoxicity using human iPSCs and rat neonatal myocytes.

    Science.gov (United States)

    Jans, Danny; Callewaert, Geert; Krylychkina, Olga; Hoffman, Luis; Gullo, Francesco; Prodanov, Dimiter; Braeken, Dries

    2017-09-01

    Drug-induced cardiotoxicity poses a negative impact on public health and drug development. Cardiac safety pharmacology issues urged for the preclinical assessment of drug-induced ventricular arrhythmia leading to the design of several in vitro electrophysiological screening assays. In general, patch clamp systems allow for intracellular recordings, while multi-electrode array (MEA) technology detect extracellular activity. Here, we demonstrate a complementary metal oxide semiconductor (CMOS)-based MEA system as a reliable platform for non-invasive, long-term intracellular recording of cardiac action potentials at high resolution. Quinidine (8 concentrations from 10 -7 to 2.10 -5 M) and verapamil (7 concentrations from 10 -11 to 10 -5 M) were tested for dose-dependent responses in a network of cardiomyocytes. Electrophysiological parameters, such as the action potential duration (APD), rates of depolarization and repolarization and beating frequency were assessed. In hiPSC, quinidine prolonged APD with EC 50 of 2.2·10 -6 M. Further analysis indicated a multifactorial action potential prolongation by quinidine: (1) decreasing fast repolarization with IC 50 of 1.1·10 -6 M; (2) reducing maximum upstroke velocity with IC 50 of 2.6·10 -6 M; and (3) suppressing spontaneous activity with EC 50 of 3.8·10 -6 M. In rat neonatal cardiomyocytes, verapamil blocked spontaneous activity with EC 50 of 5.3·10 -8 M and prolonged the APD with EC 50 of 2.5·10 -8 M. Verapamil reduced rates of fast depolarization and repolarization with IC 50 s of 1.8 and 2.2·10 -7 M, respectively. In conclusion, the proposed action potential-based MEA platform offers high quality and stable long-term recordings with high information content allowing to characterize multi-ion channel blocking drugs. We anticipate application of the system as a screening platform to efficiently and cost-effectively test drugs for cardiac safety. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. In-situ hybrid study of thermal behaviour of Znsbnd Ni and Znsbnd Nisbnd Al2O3 nanocrystallite thin films induced TEA/MEA by electrocodeposition

    Science.gov (United States)

    Abdulwahab, M.; Fayomi, O. S. I.; Popoola, A. P. I.; Dodo, M. R.

    Our present investigation focuses on the thermal stability of already developed electroforms of Znsbnd Ni and Znsbnd Nisbnd Al2O3 thin films induced with triethylamine (TEA) and monoethylamine (MEA) as surfactant by electrocodeposition on mild steel substrate with the aim to re-examine its micro-hardness and degradation behaviour in static sodium chloride solution. In the event, the samples were thermally treated at 200 °C and air cooled. The results obtained showed that the developed composites are thermally stable with hardness value of the Znsbnd Nisbnd Al2O3 coated; 185 Hv increased to 190.5 Hv indicating a 2.89% improvement. Noticeably, in the Znsbnd Ni coatings, a decrease in the hardness with 26.67% was observed. The oxidation resistance was however favored for both composites.

  16. Experiment and model for the viscosities of MEA-PEG400, DEA-PEG400 and MDEA-PEG400 aqueous solutions

    International Nuclear Information System (INIS)

    Fu, Dong; Zhang, Pan; Du, LeiXia; Dai, Jing

    2014-01-01

    Highlights: • The viscosities of the amine-PEG400 aqueous solutions were measured. • The experiments were modeled satisfactorily by using the Weiland equation. • The effect of mass fractions of amine and PEG400 on the viscosity was illustrated. • The temperature dependence of the viscosity was demonstrated. - Abstract: The viscosities (η) of poly(ethylene oxide)400 (PEG400), monoethanolamine (MEA)-PEG400, diethanolamine (DEA)-PEG400 and N-methyldiethanolamine (MDEA)-PEG400 aqueous solutions were measured by using the NDJ-5S digital rotational viscometer. A thermodynamic equation was used to model the viscosities and the calculated results are satisfactory. The effects of temperature, mass fractions of amines and PEG400 on the viscosities were demonstrated on the basis of experiments and calculations

  17. Comparison study Of H{sub 2}O determination in UO{sub 2} powder by using MEA (Moisture Evaluation Analysis) and KFT (Karl Fischer Titration); Studi banding penentuan kadar H{sub 2}O dalam serbuk UO{sub 2} menggunakan metoda MEA (Moisture Evaluation Analysis) dan KFT (Karl Fischer Titration)

    Energy Technology Data Exchange (ETDEWEB)

    Farida,; Yudhi, N; Lilis, W; Putro, P K [Center for Development of Nuclear Fuel and Recycling Technology, National Atomic Energy Agency, Serpong (Indonesia)

    2000-03-08

    To find out an analytical method to determine H{sub 2}O content in UO{sub 2} powder as fuel elements of power reactors which is simple, economical, precise, and accurate, it is necessary to do comparison study of H{sub 2}O content determination using MEA method which is based on electrolysis process with two helically wound electrodes which contains P{sub 2} O{sub 5} that has function to absorb water steam. The platinum electrodes have a 67 Volt potential on them. The quantity of charge required to electrolyse 0.1 {mu}gr of H{sub 2}O is a constant which is the basic of the electronic measurement. In KFT method is based on volumetric titration using the one component reagent hydronol composite contain all reactants i.e. iodine, sulfur dioxide and imidazole as the base, dissolved in a suitable alcohol. The t- (student) test show that there is no different result significantly between those method. The H{sub 2}O contain obtained is 0.956{+-}0.0095 %, for MEA method and 0.953{+-}0.023 % for KFT method. (author)

  18. The Study of Permanent Magnets Synchronous Machine (PMSM of the Autonomous Electric Power Supply System (ASE, compatible with the Concept of a More Electric Aircraft (MEA

    Directory of Open Access Journals (Sweden)

    Setlak Lucjan

    2018-01-01

    Full Text Available Based on the analysis and mathematical models of synchronous electric machines (motor/generator, basing on permanent magnets, presented in this paper, the main importance of alternator AC power sources in the form of starter/generator (for conventional aircraft and in the form of integrated unit starter (motor/AC synchronous generator S/G AC (with respect to advanced aircraft concept in terms of more electric aircraft was highlighted. Additionally, through the analysis and selected simulations of the on-board autonomous power supply system of the modern aircrafts, sources of electrical energy (synchronous motor/generator, integrated unit starter/AC generator were located in board autonomic power system ASE (EPS, PES. Main components of this system are the electro-energetic power system EPS and the energo-electronic power system PES. In addition, the analysis and exemplary simulations of main electricity sources based on mathematical models have contributed to highlighting the main practical applications in accordance with the concept of MEA.

  19. Improving Prediction Accuracy of a Rate-Based Model of an MEA-Based Carbon Capture Process for Large-Scale Commercial Deployment

    Directory of Open Access Journals (Sweden)

    Xiaobo Luo

    2017-04-01

    Full Text Available Carbon capture and storage (CCS technology will play a critical role in reducing anthropogenic carbon dioxide (CO2 emission from fossil-fired power plants and other energy-intensive processes. However, the increment of energy cost caused by equipping a carbon capture process is the main barrier to its commercial deployment. To reduce the capital and operating costs of carbon capture, great efforts have been made to achieve optimal design and operation through process modeling, simulation, and optimization. Accurate models form an essential foundation for this purpose. This paper presents a study on developing a more accurate rate-based model in Aspen Plus® for the monoethanolamine (MEA-based carbon capture process by multistage model validations. The modeling framework for this process was established first. The steady-state process model was then developed and validated at three stages, which included a thermodynamic model, physical properties calculations, and a process model at the pilot plant scale, covering a wide range of pressures, temperatures, and CO2 loadings. The calculation correlations of liquid density and interfacial area were updated by coding Fortran subroutines in Aspen Plus®. The validation results show that the correlation combination for the thermodynamic model used in this study has higher accuracy than those of three other key publications and the model prediction of the process model has a good agreement with the pilot plant experimental data. A case study was carried out for carbon capture from a 250 MWe combined cycle gas turbine (CCGT power plant. Shorter packing height and lower specific duty were achieved using this accurate model.

  20. Novel modulatory effects of neurosteroids and benzodiazepines on excitatory and inhibitory neurons excitability: a multi-electrode array (MEA recording study"

    Directory of Open Access Journals (Sweden)

    Giulia ePuia

    2012-11-01

    Full Text Available The balance between glutamate- and GABA-mediated neurotransmission in the brain is fundamental in the nervous system, but it is regulated by the ‘tonic’ release of a variety of endogenous factors. One such important group of molecules are the neurosteroids (NSs which, similarly to benzodiazepines (BDZs, enhance GABAergic neurotransmission. The purpose of our work was to investigate, at in-vivo physiologically relevant concentrations, the effects of NSs and BDZs as GABA modulators on dissociated neocortical neuron networks grown in long-term culture. We used a multi-electrode array (MEA recording technique and a novel analysis that was able to both identify the action potentials of engaged excitatory and inhibitory neurons and to detect drug-induced network up-states (burst. We found that the NSs tetrahydrodeoxycorticosterone (THDOC and allopregnanolone (ALLO applied at low nM concentrations, produced different modulatory effects on the two neuronal clusters. Conversely, at high concentrations (1 µM, both NSs, decreased excitatory and inhibitory neuron cluster excitability; however, even several hours after washout, the excitability of inhibitory neurons continued to be depressed, leading to a network long term depression (LTD. The BDZs clonazepam (CLZ and midazolam (MDZ also decreased the network excitability, but only MDZ caused LTD of inhibitory neuron cluster. To investigate the origin of the LTD after MDZ application, we tested finasteride (FIN, an inhibitor of endogenous NSs synthesis. FIN did not prevent the LTD induced by MDZ, but surprisingly induced it after application of CLZ. The significance and possible mechanisms underlying these LTD effects of NSs and BDZs are discussed. Taken together, our results not only demonstrate that ex-vivo networks show a sensitivity to NSs and BDZs comparable to that expressed in vivo, but also provide a new global in-vitro description that can help in understanding their activity in more complex

  1. Fabrication of MEA based on optimum amount of Co in PdxCo/C alloy nanoparticles as a new cathode for oxygen reduction reaction in passive direct methanol fuel cells

    International Nuclear Information System (INIS)

    Gharibi, Hussein; Golmohammadi, Farhad; Kheirmand, Mehdi

    2013-01-01

    Highlights: ► The optimal amount of Pd/Co in the catalyst layer reduces the polarization resistance in comparison with Pd alone. ► The Pd/Co in catalyst layer increases the Pd utilization in the ORR. ► The DMFC test results indicate that the MEA prepared from Pd 3 Co/C cathode exhibits best performance. -- Abstract: Carbon supported Pd and Pd x Co alloy electrocatalysts of different Pd x Co atomic ratios (x = 1, 2, 3 and 10) were prepared by the impregnation synthesis method at room temperature without heat treatment by ethylene glycol (EG) reduction. As prepared Pd x Co bimetallic nanoparticles show a single-phase face-centered-cubic (fcc) disordered structure. The performance of these electrodes in the ORR was measured with cyclic voltammetry (CV), linear sweep voltammetry (LSV), electrochemical impedance spectroscopy (EIS), chronoamperometry (CA), inductive coupled plasma (ICP), X-ray diffraction (XRD); scanning electron microscopy coupled to energy dispersive X-ray (SEM–EDX) and transmission electron microscope (TEM). For synthesized Pd x Co/C electrocatalysts, the highest catalytic activity for the ORR, was found for a Pd:Co atomic ratio of 3:1 in acid media at the presence and absence of methanol with optimal Pd–Pd bond distance (0.2729 nm). Since the Pd x Co/C alloy electrocatalysts are inactive for the adsorption and oxidation of methanol, it can act as a methanol-tolerant ORR catalyst in a direct methanol fuel cell (DMFC). A membrane-electrode assembly (MEA) has been prepared by employing of the Pd 3 Co/C as a cathode for passive direct methanol fuel cell and characterized by polarization curves and impedance diagrams. The DMFC test results indicate that the MEA prepared from Pd 3 Co/C cathode exhibits better performance compared to the MEA prepared from Pt/C (Electrochem) and an in-house Pd/C catalyst synthesized, in terms of maximum power density and minimum charge transfer resistance

  2. Experimental investigation of air relative humidity (RH) cycling tests on MEA/cell aging in PEMFC. Pt. II. Study of low RH cycling test with air RH at 62%/0%

    Energy Technology Data Exchange (ETDEWEB)

    Huang, B.T.; Chatillon, Y.; Bonnet, C.; Lapicque, F. [Laboratoire Reactions et Genie des Procedes, CNRS-Nancy University, Nancy (France); Leclerc, S. [Laboratoire d' Energetique et de Mecanique Theorique et Appliquee, CNRS-Nancy University, Vandoeuvre-les-Nancy (France); Hinaje, M.; Rael, S. [Groupe de Recherche en Electrotechnique et Electronique de Nancy, Nancy University, Vandoeuvre-les-Nancy (France)

    2012-06-15

    The effect of low relative humidity (RH) cycling (RH{sub C} 62%/0%) on the degradation mechanisms of a single proton exchange membrane fuel cell (5 x 5 cm{sup 2}) was investigated and compared to a cell operated at constant humidification (RH{sub C} = 62%). The overall cell performance loss was near 33 {mu}V h{sup -1}, which is greater than the voltage decay under constant RH condition near 3 {mu}V h{sup -1}. The electroactive surface was reduced but to an acceptable level. Impedance spectroscopy revealed that the ohmic and charge transfer resistances were reduced by the likely improved hydration of the ionomeric layer at the catalyst due to hydrogen crossover. This was so important that H{sub 2} starvation was finally responsible for the collapse of the cell after 650 h. Transmission electron microscopy showed occurrence of various phenomena, e.g., bubbles and pinholes formation in the membrane due to local overheat from hydrogen combustion at the cathode, and thickness reduction of catalytic layers. The water up take obtained by {sup 1}H NMR within the membrane electrode assembly (MEA) after low RH cycling reduced by 24% compared to a fresh MEA. Observations are also compared to those obtained at high RH cycling (RH{sub C} 62%/100%) presented in Part I of this study [1]. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  3. CSAHi study-2: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes: Assessment of reference compounds and comparison with non-clinical studies and clinical information.

    Science.gov (United States)

    Nozaki, Yumiko; Honda, Yayoi; Watanabe, Hitoshi; Saiki, Shota; Koyabu, Kiyotaka; Itoh, Tetsuji; Nagasawa, Chiho; Nakamori, Chiaki; Nakayama, Chiaki; Iwasaki, Hiroshi; Suzuki, Shinobu; Tanaka, Kohji; Takahashi, Etsushi; Miyamoto, Kaori; Morimura, Kaoru; Yamanishi, Atsuhiro; Endo, Hiroko; Shinozaki, Junko; Nogawa, Hisashi; Shinozawa, Tadahiro; Saito, Fumiyo; Kunimatsu, Takeshi

    2017-08-01

    With the aim of reconsidering ICH S7B and E14 guidelines, a new in vitro assay system has been subjected to worldwide validation to establish a better prediction platform for potential drug-induced QT prolongation and the consequent TdP in clinical practice. In Japan, CSAHi HEART team has been working on hiPS-CMs in the MEA (hiPS-CMs/MEA) under a standardized protocol and found no inter-facility or lot-to-lot variability for proarrhythmic risk assessment of 7 reference compounds. In this study, we evaluated the responses of hiPS-CMs/MEA to another 31 reference compounds associated with cardiac toxicities, and gene expression to further clarify the electrophysiological characteristics over the course of culture period. The hiPS-CMs/MEA assay accurately predicted reference compounds potential for arrhythmogenesis, and yielded results that showed better correlation with target concentrations of QTc prolongation or TdP in clinical setting than other current in vitro and in vivo assays. Gene expression analyses revealed consistent profiles in all samples within and among the testing facilities. This report would provide CiPA with informative guidance on the use of the hiPS-CMs/MEA assay, and promote the establishment of a new paradigm, beyond conventional in vitro and in vivo assays for cardiac safety assessment of new drugs. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Techno-economic study of CO{sub 2} capture from an existing coal-fired power plant: MEA scrubbing vs. O{sub 2}/CO{sub 2} recycle combustion

    Energy Technology Data Exchange (ETDEWEB)

    Singh, D; Croiset, E; Douglas, P L [Waterloo Univ., Dept. of Chemical Engineering, Waterloo, ON (Canada); Douglas, M A [Natural Resources Canada, CANMET Energy Technology Centre, Nepean, ON (Canada)

    2003-11-01

    The existing fleet of modern pulverised coal fired power plants represents an opportunity to achieve significant reductions in greenhouse gas emissions in the coming years providing that efficient and economical CO{sub 2} capture technologies are available for retrofit. One option is to separate CO{sub 2} from the products of combustion using conventional approaches such as amine scrubbing. An emerging alternative, commonly known as O{sub 2}/CO{sub 2} recycle combustion, involves burning the coal with oxygen in an atmosphere of recycled flue gas. Both approaches can be retrofitted to existing units, however they consume significant amounts of energy to capture, purify and compress the CO{sub 2} for subsequent sequestration. This paper presents a techno-economic comparison of the performance of the two approaches. The comparison was developed using the commercial process simulation packages, Hysys and Aspen Plus. The results show that both processes are expensive options to capture CO{sub 2} from coal power plants, however O{sub 2}/CO{sub 2} appears to be a more attractive retrofit than MEA scrubbing. The CO{sub 2} capture cost for the MEA case is USD 53/ton of CO{sub 2} avoided, which translates into 3.3 cent/kW h. For the O{sub 2}/CO{sub 2} case the CO{sub 2} capture cost is lower at USD 35/ton of CO{sub 2} avoided, which translates into 2.4 cent/kW h. These capture costs represent an approximate increase of 20-30% in current electricity prices. (Author)

  5. Experimental investigation of air relative humidity (RH) cycling tests on MEA/cell aging in PEMFC. Pt. I. Study of high RH cycling test with air RH at 62%/100%

    Energy Technology Data Exchange (ETDEWEB)

    Huang, B.T.; Chatillon, Y.; Bonnet, C.; Lapicque, F. [Laboratoire Reactions et Genie des Procedes, CNRS-Nancy University, Nancy (France); Leclerc, S. [Laboratoire d' Energetique et de Mecanique Theorique et Appliquee, CNRS-Nancy University, Vandoeuvre-les-Nancy (France); Hinaje, M.; Rael, S. [Groupe de Recherche en Electrotechnique et Electronique de Nancy, CNRS-Nancy University, Vandoeuvre-les-Nancy (France)

    2012-06-15

    The effect of high air relative humidity (RH) cycling (RH{sub C} 62%/100%) on the degradation mechanisms of a single (5 x 5 cm{sup 2}) proton exchange membrane fuel cells was investigated. The cell performance was compared to a cell operated at constant humidification (RH{sub C} = 62%). Runs were conducted over approximately 1,500 h at 0.3 A cm{sup -2}. The overall loss in cell performance for the high RH cycling test was 12 {mu}V h{sup -1} whereas it was at 3 {mu}V h{sup -1} under constant humidification. Impedance spectroscopy reveals that the ohmic and charge transfer resistances were little modified in both runs. H{sub 2} crossover measurement indicated that both high RH cycling and constant RH test did not promote serious effect on gas permeability. The electroactive surface loss for anode and cathode during high air RH cycling was more significant than at constant RH operation. The water uptake determined by {sup 1}H nuclear magnetic resonance within the membrane electrode assembly (MEA) after high RH cycling was reduced by 12% in comparison with a fresh MEA. Transmission electron microscopy showed bubbles and pinholes formation in the membrane, catalyst particles agglomeration (also observed by X-ray diffraction), catalyst particles migration in the membrane and thickness reduction of the catalytic layers. Scanning electron microscopy was conducted to observe the changes in morphology of gas diffusion layers after the runs. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  6. Study and development of membrane electrode assemblies for Proton Exchange Membrane Fuel Cell (PEMFC) with palladium based catalysts; Estudo e desenvolvimento de conjuntos membrana-eletrodos (MEA) para celula a combustivel de eletrolito polimerico condutor de protons (PEMFC) com eletrocatalisadores a base de paladio

    Energy Technology Data Exchange (ETDEWEB)

    Bonifacio, Rafael Nogueira

    2013-07-01

    PEMFC systems are capable of generating electricity with high efficiency and low or no emissions, but durability and cost issues prevent its large commercialization. In this work MEA with palladium based catalysts were developed, Pd/C, Pt/C and alloys PdPt/C catalysts with different ratios between metals and carbon were synthesized and characterized. A study of the ratio between catalyst and Nafion Ionomer for formation of high performance triple-phase reaction was carried out, a mathematical model to implement this adjustment to catalysts with different relations between metal and support taking into account the volumetric aspects of the catalyst layer was developed and then a study of the catalyst layer thickness was performed. X-ray diffraction, Transmission and Scanning Electron Microscopy, X-ray Energy Dispersive, Gas Pycnometry, Mercury Intrusion Porosimetry, Gas adsorption according to the BET and BJH equations, and Thermo Gravimetric Analysis techniques were used for characterization and particle size, specific surface areas and lattice parameters determinations were also carried out. All catalysts were used on MEAs preparation and evaluated in 5 cm{sup 2} single cell from 25 to 100 °C at 1 atm and the best composition was also evaluated at 3 atm. In the study of metals for reactions, to reduce the platinum applied to the electrodes without performance losses, Pd/C and PdPt/C 1:1 were selected for anodes and cathodes, respectively. The developed MEA structure used 0,25 mgPt.cm{sup -2}, showing power densities up to 550 mW.cm{sup -2} and power of 2.2 kW{sub net} per gram of platinum. The estimated costs showed that there was a reduction of up to 64.5 %, compared to the MEA structures previously known. Depending on the temperature and operating pressure, values from US$ 1,475.30 to prepare MEAs for each installed kilowatt were obtained. Taking into account recent studies, it was concluded that the cost of the developed MEA is compatible with PEMFC stationary

  7. Desenvolvimento de tecnologia para confecção de eletrodos e conjuntos eletrodo-membrana-eletrodo (MEA por impressão à tela para aplicação em módulos de potência de células PEMFC

    Directory of Open Access Journals (Sweden)

    Valéria Cristina Fernandes

    2012-01-01

    Full Text Available Significant functions in the Proton Exchange Membrane Fuel Cells (PEMFCs rely on Gas Diffusion Layers (GDLs, such as control the water balance in the membrane electrode assembly (MEA, allow suitable gas permeability and porosity, etc. Aware of the GDL importance in the cell performance and its great demand in scale-up projects, the fuel cell research group at Instituto de Pesquisas Energéticas e Nucleares (IPEN has developed a Sieve Printing method (innovative in Brazil as a strategic solution for producing GDL and electrodes used in high power PEMFC stacks. The method has shown to be adequate to fabricate low cost electrodes, GDLs of different dimensions and to produce any amount of MEAs for power stacks.

  8. Engineered Nanostructured MEA Technology for Low Temperature Fuel Cells

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Yimin

    2009-07-16

    The objective of this project is to develop a novel catalyst support technology based on unique engineered nanostructures for low temperature fuel cells which: (1) Achieves high catalyst activity and performance; (2) Improves catalyst durability over current technologies; and (3) Reduces catalyst cost. This project is directed at the development of durable catalysts supported by novel support that improves the catalyst utilization and hence reduce the catalyst loading. This project will develop a solid fundamental knowledge base necessary for the synthetic effort while at the same time demonstrating the catalyst advantages in Direct Methanol Fuel Cells (DMFCs).

  9. A new conception for the central control facility of MEA

    International Nuclear Information System (INIS)

    Schimmel, F.

    1986-01-01

    To control the AFBU from the Central Control Facility some change will be necessary. This has led to a complete revision of the facilities of both consoles. Some proposals are made to improve the response time of the control systems. These improvements are feasible at short notice. (G.J.P.)

  10. Data for Brown et al MEA Developmental Neurotoxicity Screening Manuscript

    Data.gov (United States)

    U.S. Environmental Protection Agency — These data are the individual parameter and well-level data that were support the conclusions in Brown et al. Note: the parameters CVtime and CVnetwork were not...

  11. The MEA syndrome - a contribution based on pictorial case records

    International Nuclear Information System (INIS)

    Brandstetter, K.; Luttke, G.; Golder, W.

    1991-01-01

    Multiple endocrine adenomatosis is defined as being a hereditary, pluriglandular syndrome associated with hyperplastic and neoplastic changes. The range of methods used included sonography, magnetic resonance tomography and angiography. (GDG) [de

  12. the development and application of a fabric objective meas

    African Journals Online (AJOL)

    user

    the Fabric Assurance by Simple Testing (FAST). FOM system. .... and longitudinal compressional properties, or ... most likely to be the source of making-up related .... Multiple. R-sq. Adj. R-sq. Blend. 194.4533. 1. 194.4533. 146.438. 0.0000.

  13. Safety assessment of Salicylic Acid, Butyloctyl Salicylate, Calcium Salicylate, C12-15 Alkyl Salicylate, Capryloyl Salicylic Acid, Hexyldodecyl Salicylate, Isocetyl Salicylate, Isodecyl Salicylate, Magnesium Salicylate, MEA-Salicylate, Ethylhexyl Salicylate, Potassium Salicylate, Methyl Salicylate, Myristyl Salicylate, Sodium Salicylate, TEA-Salicylate, and Tridecyl Salicylate.

    Science.gov (United States)

    2003-01-01

    Salicylic Acid is an aromatic acid used in cosmetic formulations as a denaturant, hair-conditioning agent, and skin-conditioning agent--miscellaneous in a wide range of cosmetic products at concentrations ranging from 0.0008% to 3%. The Calcium, Magnesium, and MEA salts are preservatives, and Potassium Salicylate is a cosmetic biocide and preservative, not currently in use. Sodium Salicylate is used as a denaturant and preservative (0.09% to 2%). The TEA salt of Salicylic Acid is used as an ultraviolet (UV) light absorber (0.0001% to 0.75%). Several Salicylic Acid esters are used as skin conditioning agents--miscellaneous (Capryloyl, 0.1% to 1%; C12-15 Alkyl, no current use; Isocetyl, 3% to 5%; Isodecyl, no current use; and Tridecyl, no current use). Butyloctyl Salicylate (0.5% to 5%) and Hexyldodecyl Salicylate (no current use) are hair-conditioning agents and skin-conditioning agents--miscellaneous. Ethylhexyl Salicylate (formerly known as Octyl Salicylate) is used as a fragrance ingredient, sunscreen agent, and UV light absorber (0.001% to 8%), and Methyl Salicylate is used as a denaturant and flavoring agent (0.0001% to 0.6%). Myristyl Salicylate has no reported function. Isodecyl Salicylate is used in three formulations, but no concentration of use information was reported. Salicylates are absorbed percutaneously. Around 10% of applied salicylates can remain in the skin. Salicylic Acid is reported to enhance percutaneous penetration of some agents (e.g., vitamin A), but not others (e.g., hydrocortisone). Little acute toxicity (LD(50) in rats; >2 g/kg) via a dermal exposure route is seen for Salicylic Acid, Methyl Salicylate, Tridecyl Salicylate, and Butyloctyl Salicylate. Short-term oral, inhalation, and parenteral exposures to salicylates sufficient to produce high blood concentrations are associated primarily with liver and kidney damage. Subchronic dermal exposures to undiluted Methyl Salicylate were associated with kidney damage. Chronic oral exposure to

  14. Pengaruh Pendekatan MEAs terhadap Kemampuan Pemecahan Masalah, Komunikasi Matematis, dan Kepercayaan Diri Siswa

    OpenAIRE

    Palupi Sri Wijayanti

    2013-01-01

    Penelitian ini bertujuan untuk mendeskripsikan pengaruh: (1) peringkat sekolah terhadap kemampuan pemecahan masalah siswa, komunikasi matematis, dan kepercayaan diri siswa; (2) pendekatan pembelajaran terhadap kemampuan pemecahan masalah siswa, komunikasi matematis, dan kepercayaan diri siswa; (3) interaksi peringkat sekolah dan pendekatan pembelajaran terhadap kemampuan pemecahan masalah siswa, komunikasi matematis, dan kepercayaan diri siswa. Hasil penelitian menunjukkan bahwa sebagai berik...

  15. PENGEMBANGAN PROGRAM PENDIDIKAN DI SD ISLAM INTERNASIONAL AL-ABIDIN SURAKARTA DALAM MENGHADAPI MEA

    Directory of Open Access Journals (Sweden)

    Tsabita Fiki Amalia

    2016-12-01

    Full Text Available ASEAN Economic Community (AEC ia an integratied system of the countries in Southeast Asia that enable and facilitate the free trade system. Since 2015 the AEC has been officially started, and many foreign companies has been opened in Indonesia. However, the quality of Human Resources (HR in Indonesia is lacking to confront AEC’s system. It can be seen from the number of unemployed people in Indonesia and Indonesian citizen education level is still low. This shows a lack of quality in education. Departing from this problem, the authors conducted research at the international elementary school, SDII Al Abidin Surakarta. This school has excellent programs that can be developed and replicated in order to improve the quality of Human Resources (HR since elementary school. This research aims to study programs that are run in order to deal with AEC. This research was conducted with a qualitative descriptive method by collecting data through interviews, observation, and documentation. The results showed some excellent programs that are owned by SDII Al Abidin Surakarta which can be used as a weapon to face the ASEAN Economic Community (AEC. The programs are international curriculum, three varians grade programs, and extracurricular.

  16. Meas.of the Ratio Between Double and Single Ionization of Helium for Antiprotons

    CERN Multimedia

    2002-01-01

    The aim of this experiment is to measure the ratio between double and single ionization of helium by antiprotons in the energy range $>$~3~MeV. Comparison with already existing proton data will yield information on the mechanisms for double ionization, which could not be extracted from previous comparisons between ratios measured for equivelocity electrons and protons. The most basic information to be obtained from an antiproton experiment will be the amount of correlation existing between the two electrons in the ground-state helium atom.\\\\ \\\\ The equipment consists of a gas cell, which employs slow-ion collection via the so-called condenser-plate method for the absolute sum of partial-ionization cross sections and determination of the relative contribution of multiple charged ions by TOF. The gas cell has movable entrance and exit slits and a grid system to account for secondary emission from the collection of slow ions. Together with a field of 800~V/cm in the collision region, the potentials of the TOF sp...

  17. MUSYARAKAH FINANCE PROSPECT IN ISLAMIC BANK IN THE FACE OF ASEAN ECONOMIC COMMUNITY (MEA

    Directory of Open Access Journals (Sweden)

    Ahmad Supriyadi

    2016-11-01

    Full Text Available In the era of Dutch colonial, the majority of entrepreneurs in Central Java and Yogyakarta come from the students. But after Indonesian independence, the students did not show up in the business world because of political policy. Nowadays the entrepreneur students bounced back with Islamic banks that one of its products is a Musharakah finance. Musharakah finance deal with the birth of the free market, namely the ASEAN Economic Community so that the question arises how the prospect Musharakah finance in Indonesian Islamic banks of facing the ASEAN Economic Community (AEC. This paper aims to describe the prospect of Musharakah finance to face AEC. The results showed that the Musharakah finance has a lot of prospects such as financing products that can be performed well and have a competitive value because it has a solid legal basis. From the network side, Islamic banks have been supported by a network offices that much better at home and abroad with excellent quality customer service. In addition, the presence Bank Indonesia blueprint of the Islamic banking institution can strengthen the Musharakah finance products so that can be applied in the ASEAN Economic Community (AEC.

  18. Impact of aircraft systems within aircraft operation: A MEA trajectory optimisation study

    OpenAIRE

    Seresinhe, R.

    2014-01-01

    Air transport has been a key component of the socio-economic globalisation. The ever increasing demand for air travel and air transport is a testament to the success of the aircraft. But this growing demand presents many challenges. One of which is the environmental impact due to aviation. The scope of the environmental impact of aircraft can be discussed from many viewpoints. This research focuses on the environmental impact due to aircraft operation. Aircraft operation causes...

  19. High-Repetition-Rate Interferometric Rayleigh Scattering for Velocity, Density, and Temperature Meas, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Large ground-test facilities, which simulate real flow conditions from subsonic to hypersonic, are used extensively to generate forces and moments as well as surface...

  20. Activity of bimetallic catalysts (Pt + Me)/A12030 in butane hydrogenolysis and benzene hydrogenation

    International Nuclear Information System (INIS)

    Zharkov, B.B.; Rubinov, A.Z.

    1986-01-01

    The authors evaluate the decomposing and hydrogenating activity of some Me/Al 2 0 3 0 and (Pt + Me)/Al 203 catalysis for the reactions of butane hydrogenolysis and conversion of benzene to cyclohexane. The temperature was 180-300 C for butane transformation and 150 C for benzene hydrogenation. During both reactions some initial decrease of catalytic activity which stabilized over 2-3 h was observed. The results show that roasting Re-containing reforming catalysts at fairly high temperatures (500-550 C) balances maximum hydrogenating and average splitting activities, thus guaranteeing high resistance to coke deposition while preserving the necessary selectivity. The decreased hydrogenating capacity of Ir/A1 2 0 3 0 and (Pt + Ir)/A1 23 0 catalysts after roasting at 500 C indicates insufficient thermal stability, which can be why renewing the initial activity of iridium containing forming catalysts by oxidating regeneration is difficult

  1. CHANNELING: SEARCH OF THE METAANTHROPOLOGIC MEAS-UREMENTS OF MIND BEING IN THE UNIVERSE (based on the World Wide Web

    Directory of Open Access Journals (Sweden)

    Anatoly T. Tshedrin

    2014-06-01

    Full Text Available The relevance of the study. In the context of religious and philosophical movements of the «New Age» gained channeling phenomenon – «laying channel», «transmission channel» information from the consciousness that is not in human form, to the individual and humanity as a whole. In the socio-cultural environment of the postmodern channeling reflects the problem of finding extraterrestrial intelligence (ETI; «ETC-problem»; SETІ problem and to establish contacts with them, this problem has a different projection, important philosophical and anthropological measurements in culture. Investigation of mechanisms of constructing virtual superhuman personalities in the world web is not only of interest for further analysis of the problem of extraterrestrial intelligence (ETI, but also to extend subject field of anthropology of the Internet as an important area of philosophical and anthropological studies. The purpose of the study. Analysis of the phenomenon of channeling as a projection of the fundamental problems of life ETI, its representation on the World Wide Web, the impact on the archaism of postmodern culture posing problems meta an-thropological dimensions of existence in the universe of reason and contact with him in the doctrinal grounds channeling. Analysis of research on the problem and its empirical base. Clustered nature of the problem of ETI and channeling its element involves the widespread use of radio astronomy paradigm works carriers solve CETI; work in anthropology Internet; works of researchers of the phenomenon of «New Age». Empirical basis of the study are network resources, as well as texts–representatives created and introduced into circulation by the channelers, their predecessors. Research Methodology. Channeling as an object of research, its network of representation – as a matter of methods involve the use of analytical hermeneutics and archaeographic commenting text fractal logic cluster analysis. The main body. The features of channeling as cultural practices aimed at solving the problem of finding meta an-thropological dimensions of existence in the universe of the mind, as an attempt to resolve the contradiction between the theoretical ideas about extraterrestrial civilizations and the lack of empirically observable, the expected signs of their activities. The analysis of the solutions to the problems being ETI loci, its substrate base forms of activity in the Earth's socio-cultural space that offers channeling. Considered as a complete retrospective of channeling cultural practices that emerged in the western segment of the socio-cultural environment, especially its being presented in the form of postmodern religion, emphasized the role of channeling as an indicator cosmization archaism and modern culture. Scientific novelty. Channeling is one of the sociocultural system reactions on Earth absence of bilateral contacts with the ETC. Studying the mechanisms of constructing virtual superhuman personalities in the global network is one of the directions of further development of subject- thematic field of anthropology of the Internet as an important area of philosophical and anthropological studies. Conclusions. Channeling as a holistic, complex structure phenomenon connects the dynamics of transformation of humanity with establishing contacts with polymorphic ETI. Channeling is one of the sociocultural system reactions on Earth absence of bilateral contacts with the ETC. In the development of channeling manifest fractal effects associated with the reproduction of their previous ideas about the history of ETI. Retrospection channeling as cultural practices show his obedience to the law of the cultural series: a temporary phenomenon in the long-range specific chronotope culture is defined by its inclusion in the actually exist-ing set of genetically related forms.

  2. PALMA (OPUNTIA FICUS INDICA MILL CV. GIGANTE EM SUPLEMENTOS PARA FÊMEAS LEITEIRAS EM CRESCIMENTO A PASTO

    Directory of Open Access Journals (Sweden)

    GLEIDIANA AMÉLIA PONTES DE ALMEIDA

    2015-01-01

    Full Text Available This study aimed at evaluating the effect of replacing corn by palm in the supplements for dairy females in grazing at levels of 0, 33, 66 and 100%. Intake of pasture and apparent nutrient digestibility, animal performance, intake of nitrogenous compounds, nitrogen balance, synthesis and microbial efficiency and bioe-conomy system were evaluated. The study was conducted at Farm Roçadinho, municipality of Capoeiras Wasteland region of the State of Pernambuco in the period from 30/09/2012 to 19/01/2013, in a completely randomized design with four treatments and six replications, using 24 dairy females growing initial weight of 180 pounds. Consisted of 112 days, and 28 for adaptation. The intake of DM, DM/pasture, OM, CP, NDFap. NDFi intake and increased ADF because of the NFC, EE, and TDN decreased (P <0.05. PUN levels in plasma did not change. The apparent digestibility of DM, OM, NDF, ADF, NFC, EE and TDN decreased linearly, and CP increased (P <0.05. Weight gains decreased since the FC increased (P <0.05. No effect was observed in nitrogen intake and nitrogen excreted in the urine. A reduction in nitrogen excreted in the faeces nitrogen bal-ance and percentage of ingested nitrogen, urea-N excreted in the urine increased (P <0.05. The replacement of corn by palm reduces the performance of dairy females in pasture growth. Thus the total or partial replacement is conditioned to the projection of age at first calving on the production system and economy of use.

  3. MEaSUREs Northern Hemisphere State of Cryosphere Daily 25km EASE-Grid 2.0

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set reports the location of Northern Hemisphere snow cover and sea ice extent, the status of melt onset across Greenland and Artic sea ice, and the level...

  4. Electrophysiological analysis of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) using multi-electrode arrays (MEAs)

    NARCIS (Netherlands)

    Sala, Luca; Ward-van Oostwaard, Dorien; Tertoolen, Leon G.J.; Mummery, Christine L.; Bellin, Milena

    2017-01-01

    Cardiomyocytes can now be derived with high efficiency from both human embryonic and human induced-Pluripotent Stem Cells (hPSC). hPSC-derived cardiomyocytes (hPSC-CMs) are increasingly recognized as having great value for modeling cardiovascular diseases in humans, especially arrhythmia syndromes.

  5. Radiotelemetry Study of a Desert Tortoise Population: Sand Hill Training Mea, Marine Corps Air Ground Combat Center, Twentynine Palms, California

    Science.gov (United States)

    1998-05-01

    shallow caliche burrows. Mojave populations differ genetically ( Lamb et al. 1989), morphologically (Weinstein and Berry 1987), in burrow construction...34 Abstract in The Desert Tortoise Council Symposium (1995d), p 92. Lamb , T., J.C. Avise, and J.W. Gibbons, "Phylogeographic Patterns in Mitochondrial...ATTN: STEWS -EL US Army Envr Hygiene Agency ATTN:HSHB-ME 21010 US Army Environmental Center ATTN: SFIM-AEC 21010-5401 Defense Tech Info Center

  6. Status report 500 MeV, 10% d.f. linear accelerator (MEA) under construction at Amsterdam

    International Nuclear Information System (INIS)

    Bruinsma, P.J.T.; Vries, C. de.

    1979-03-01

    The design parameters and the general lay-out of buildings and of the main components of the accelerator are presented. Some of the accelerator technology features which are typical for the Amsterdam machine are then described. The performance obtained so far with the first part of the machine is indicated with some remarks on the planning for the next 2 years during which the facility ought to be fully operational. The type of experimental facilities under construction are described and the status and the planning schedule are indicated. (Auth.)

  7. The low energy (140 MeV) chemistry facility at the 500 MeV electron accelerator MEA at Amsterdam

    International Nuclear Information System (INIS)

    Brinkman, G.A.; Kapteyn, J.C.; Louwrier, P.W.F.; Lindner, L.; Peelen, B.; Polak, P.; Schimmel, A.; Stock, F.R.; Veenboer, J.T.; Visser, J.

    1980-01-01

    The facility includes the Low Energy Chemistry (LECH) hall equipped with a beam-line for pulse-radiolysis and a second one for the production of radioisotopes and for experiments with electron-free photon beams. It also includes the Low Energy Laboratory (LELAB) containing two chemistry laboratories and a control room. These facilities are also available to outside research groups. (orig./HP)

  8. Traffic model for commercial payloads in the Materials Experiment Assembly (MEA). [market research in commercial space processing

    Science.gov (United States)

    Tietzel, F. A.

    1979-01-01

    One hundred individuals representing universities, technical institutes, government agencies, and industrial facilities were surveyed to determine potential commercial use of a self-contained, automated assembly for the space processing of materials during frequent shuttle flights for the 1981 to 1987 period. The approach used and the results of the study are summarized. A time time-phased projection (traffic model) of commercial usage of the materials experiment assembly is provided.

  9. Putting the MeaT into TeaM Training: Development, Delivery, and Evaluation of a Surgical Team-Training Workshop.

    Science.gov (United States)

    Seymour, Neal E; Paige, John T; Arora, Sonal; Fernandez, Gladys L; Aggarwal, Rajesh; Tsuda, Shawn T; Powers, Kinga A; Langlois, Gerard; Stefanidis, Dimitrios

    2016-01-01

    Despite importance to patient care, team training is infrequently used in surgical education. To address this, a workshop was developed by the Association for Surgical Education Simulation Committee to teach team training using high-fidelity patient simulators and the American College of Surgeons-Association of Program Directors in Surgery team-training curriculum. Workshops were conducted at 3 national meetings. Participants completed preworkshop and postworkshop questionnaires to define experience, confidence in using simulation, intention to implement, as well as workshop content quality. The course consisted of (A) a didactic review of Preparation, Implementation, and Debriefing and (B) facilitated small group simulation sessions followed by debriefings. Of 78 participants, 51 completed the workshops. Overall, 65% indicated that residents at their institutions used patient simulation, but only 33% used the American College of Surgeons-the Association of Program Directors in Surgery team-training modules. The workshop increased confidence to implement simulation team training (3.4 ± 1.3 vs 4.5 ± 0.9). Quality and importance were rated highly (5.4 ± 00.6, highest score = 6). Preparation for simulation-based team training is possible in this workshop setting, although the effect on actual implementation remains to be determined. Copyright © 2015 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

  10. CO2 Capture Dynamic and Steady-State Model Development, Optimization and Control: Applied to Piperazine and Enzyme Promoted MEA/MDEA

    DEFF Research Database (Denmark)

    Gaspar, Jozsef

    the market in the coming decades. However, the growing focus on mitigation of anthropogenic CO2 requires integration of fossil-fuel fired power plant with CO2 capture units. Post-combustion capture is the most mature capture technology and it is suitable for various processes in power plants, steel industry......, cement production, and bio-chemical industry. However, to make CO2 capture economically attractive, design of innovative solvents, optimization of operation conditions/process configuration and operational flexibility are of crucial importance. This thesis aims to contribute to the development...

  11. Stress testing of electrically active FlexMEAs with simultaneous electrical recording in fluidic environment: Introduction of a new measurement setup

    Science.gov (United States)

    Westerhausen, Markus; Martin, Tanja; Kappel, Marcel; Hofmann, Boris

    2018-02-01

    We present a measurement setup consisting of two fluid-filled pressure chambers to mimic the mechanical stress likely to that of small body movements on biomedical flexible micro-electrode arrays for the analysis of various degradation mechanisms. Our main goal was the simulation of micro-motions in fluid conditions, while maintaining an electric access to the device. These micro-motions would be likely to those occurring in the human body caused by the intracranial pressure in magnitudes of 7-25 mmHg, which translates to a fluid pressure of 9-33 mbar. Furthermore, severe mechanical stress can be administered to the samples under the previously mentioned environment. Therefore, a flexible, polyimide-based sample with various metal test structures was fabricated and analyzed in the presented measurement setup. A comparison of the elongation of the sample's surface as a function of the applied hydrostatic pressure is given with computer simulations.

  12. Agreement between the Board of Control of Ferris State College and the Ferris College Faculty Association (MEA/NEA), November 12, 1984-June 30, 1987.

    Science.gov (United States)

    Michigan Education Association, East Lansing.

    The collective bargaining agreement between the Board of Ferris State College and Ferris Faculty Association Chapter (507 members), an affiliate of the National Education Association and the Michigan Education Association, covering the period November 12, 1984-June 30, 1987 is presented. Items covered in the agreement include: unit recognition,…

  13. DETERMINAÇÃO DO NÚMERO DE FÊMEAS VIRGENS POR ARMADILHA E PERIODICIDADE DE CAPTURA DE MACHOS DE Helicoverpa zea (BODDIE (LEPIDOPTERA: NOCTUIDAE

    Directory of Open Access Journals (Sweden)

    MATRANGOLO W.J.R

    1996-01-01

    Full Text Available Avaliou-se em lavouras de milho em fase de liberação de estilo-estigmas, na EMBRAPA/CNPMS, em Sete Lagoas, MG, a atratividade de diferentes números de fêmeas virgens de Helicoverpa zea (Boddie em armadilha adesiva, além de uma formulação comercial do feromônio sintético, proveniente dos E.E.U.U. A maior atividade de procura por acasalamento teve início nas primeiras horas da noite. Não houve diferença significativa entre médias de insetos capturados com uma, três ou cinco fêmeas. Cinco fêmeas por armadilha tornam o monitoramento pouco prático; uma apenas pode comprometer a captura por disfunção fisiológica ou mesmo morte. Não houve captura nas armadilhas contendo feromônio sintético, que, ao invés, capturou machos de Mythimna, outro Noctuidae. A maior freqüência de captura nas armadilhas ocorreu após a meia noite, diminuindo próximo do alvorecer. O horário de início de chamamento e captura esteve estreitamente relacionado com a temperatura ambiente.

  14. Analysis of the Durability of PEM FC Membrane Electrode Assemblies in Automotive Applications through the Fundamental Understanding of Membrane and MEA Degradation Pathways

    Energy Technology Data Exchange (ETDEWEB)

    Perry, Randal L. [DuPont

    2013-10-31

    The Project focused on mitigation of degradation processes on membrane electrode assemblies. The approach was to develop a model to improve understanding of the mechanisms, and to use it to focus mitigation strategies. The detailed effects of various accelerated stress tests (ASTs) were evaluated to determine the best subset to use in model development. A combination of ASTs developed by the Fuel Cell Commercialization Conference of Japan and the Fuel Cell Tech Team were selected for use. The ASTs were compared by measuring effects on performance, running in-situ diagnostics, and performing microscopic analyses of the membrane electrode assemblies after the stress tests were complete. Nissan ran FCCJ AST protocols and performed in situ and ex-situ electrochemical testing. DuPont ran FCTT and USFCC AST protocols, performed scanning and transmission electron microscopy and ran in-situ electrochemical tests. Other ex-situ testing was performed by IIT, along with much of the data analysis and model development. These tests were then modified to generate time-dependent data of the degradation mechanisms. Three different catalyst types and four membrane variants were then used to generate data for a theoretically-based degradation model. An important part of the approach was to use commercially available materials in the electrodes and membranes made in scalable semiworks processes rather than lab-based materials. This constraint ensured all materials would be practicable for full-scale testing. The initial model for the electrode layer was tested for internal consistency and agreement with the data. A Java-based computer application was developed to analyze the time-dependent AST data using polarization curves with four different cathode gas feeds and generate model parameters. Data showed very good reproducibility and good consistency as cathode catalyst loadings were varied. At the point of termination of the project, a basic electrode model was in hand with several areas identified for improvement. Time dependence and the membrane portion of the model were not addressed due to cancellation of Phase 2 of the Project.

  15. OBJETOS RELACIONAIS AMERÍNDIOS: SOBRE A (INVISIBILIDADE DA ARTE KADIWÉU NA NOVELA ALMA GÊMEA DA REDE GLOBO

    Directory of Open Access Journals (Sweden)

    LISIANE KOLLER LECZNIESKI

    2010-06-01

    Full Text Available RESUMO: Este texto é uma reflexão sobre o papel da cerâmica na vida social dos índios Kadiwéu que vivem na aldeia Bodoquena, situada no Pantanal sul-matogrossense, Brasil. A partir de exemplos etnográficos analiso as relações entre o mundo das artes e o mundo social, argumentando que a cerâmica atua como um eixo central em torno do qual os Kadiwéu tem articulado e dinamizado suas relações com o mundo externo, especialmente o “mundo dos brancos”. Esta compreensão marcadamente relacional dos objetos também aponta, de forma reflexiva, para aspectos cruciais da dinâmica ocidental em torno dos objetos, lançando um olhar crítico sobre as nossas concepções de relação humana.ABSTRACT: This work examines the role of ceramics in Kadiwéu social life. The Kadiwéu are Amerindians who live in the southern part of Pantanal Matogrossense, Brazil. The relations between art and social world will be described and analyzed through ethnographic examples,showing how the Kadiwéu understand their ceramic as a special way of relating to the external world, markedly the “world of the “whites”. This relational understanding of objects also points out, in a reflexive and critical manner, to crucial aspects of western conceptions of human relations.

  16. Novel modulatory effects of neurosteroids and benzodiazepines on excitatory and inhibitory neurons excitability: a multi-electrode array (MEA) recording study"

    OpenAIRE

    Giulia ePuia; Francesca eGULLO; Elena eDossi; Marzia eLecchi; Enzo eWanke

    2012-01-01

    The balance between glutamate- and GABA-mediated neurotransmission in the brain is fundamental in the nervous system, but it is regulated by the ‘tonic’ release of a variety of endogenous factors. One such important group of molecules are the neurosteroids (NSs) which, similarly to benzodiazepines (BDZs), enhance GABAergic neurotransmission. The purpose of our work was to investigate, at in-vivo physiologically relevant concentrations, the effects of NSs and BDZs as GABA modulators on dissoc...

  17. MEaSUREs Greenland Ice Mapping Project (GIMP) Digital Elevation Model from GeoEye and WorldView Imagery, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set consists of an enhanced resolution digital elevation model (DEM) for the Greenland Ice Sheet. The DEM is derived from sub-meter resolution,...

  18. A Nitrogen Response Pathway Regulates Virulence Functions in Fusarium oxysporum via the Protein Kinase TOR and the bZIP Protein MeaB

    OpenAIRE

    López-Berges, Manuel S.; Rispail, Nicolas; Prados-Rosales, Rafael C.; Pietro, Antonio D.

    2010-01-01

    During infection, fungal pathogens activate virulence mechanisms, such as host adhesion, penetration and invasive growth. In the vascular wilt fungus Fusarium oxysporum, the mitogen-activated protein kinase Fmk1 is required for plant infection and controls processes such as cellophane penetration, vegetative hyphal fusion, or root adhesion. Here, we show that these virulence-related functions are repressed by the preferred nitrogen source ammonium and restored by treatment with l-methionine s...

  19. Study of the Nafion quantity effect in membrane and electrodes assemblies (MEAs) of 50 cm{sup 2} used in type proton exchange membrane (PEM) fuel cell operating with H{sub 2}/Air; Estudo do efeito da quantidade de Nafion em MEAs de 50 cm{sup 2} utilizadas em celula a combustivel tipo PEM operando com H{sub 2}/ar

    Energy Technology Data Exchange (ETDEWEB)

    Profeti, Demetrius; Colmati, Flavio; Carlindo, Adao A.J.; Paganin, Valdecir A.; Gonzalez, Ernesto R.; Ticianelli, Edson A. [Universidade de Sao Paulo (USP), Sao Carlos, SP (Brazil). Inst. de Quimica]. E-mail: dprofeti@iqsc.usp.br

    2008-07-01

    The performance of a proton exchange membrane fuel cell (PEMFC) was investigated with the aim at characterizing the effects of the Nafion. content on the scale-up of the electrodes from 5 to 50 cm{sup 2}. It is observed that a diminution of the single cell performance occurred when the electrode area is increased from 5 to 50 cm{sup 2}. The tests carried out with different Nafion. contents, and fuel cell and humidifiers at the same temperature (T{sub cell}=T{sub H2}=T{sub air}=70 deg C) showed a slightly decrease of the fuel cell performance compared to the tests performed at different temperatures (T{sub cell}=70 deg C, T{sub H2}=85 deg C, T{sub air}=75 deg C). In the study of the variation on the Nafion. contents, the higher performance up to a current density of 0.8 A cm-2 is obtained with the 35.5 wt.% Nafion.. On the other hand, at higher current densities values, the performance of the fuel cells is very similar for the 31.0, 35.5 and 39.4 wt.% Nafion contents. (author)

  20. Syntheses of DNA adducts of two heterocyclic amines, 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA alpha C) and 2-amino-9H-pyrido[2,3-b]indole (A alpha C) and identification of DNA adducts in organs from rats dosed with MeA alpha C

    DEFF Research Database (Denmark)

    Frederiksen, Hanne; Frandsen, Henrik Lauritz; Pfau, W.

    2004-01-01

    2-Amino-3-methyl-9H-pyrido[2,3-b]indole (MeAalphaC) and 2-amino-3-methyl-9H-pyrido[2,3-b]indole (AalphaC) are mutagenic and carcinogenic heterocyclic amines formed during ordinary cooking. MeAalphaC and AalphaC are activated to mutagenic metabolites by cytochrome P450-mediated N-oxidation...... by reaction of the parent amines with acetylated guanine N3-oxide. N-2-OH-MeAalphaC and N-2-OH-AalphaC reacted with calf thymus DNA after addition of acetic anhydride. P-32-postlabelling analysis of modified DNA showed one major adduct co-migrating with N-2-(3',5'-diphospho-2'-deoxyguanosin-8-yl...

  1. Neonatal paternal deprivation impairs social recognition and alters levels of oxytocin and estrogen receptor α mRNA expression in the MeA and NAcc, and serum oxytocin in mandarin voles.

    Science.gov (United States)

    Cao, Yan; Wu, Ruiyong; Tai, Fadao; Zhang, Xia; Yu, Peng; An, Xiaolei; Qiao, Xufeng; Hao, Ping

    2014-01-01

    Paternal care is necessary for the healthy development of social behavior in monogamous rodents and social recognition underpins social behavior in these animals. The effects of paternal care on the development of social recognition and underlying neuroendocrine mechanisms, especially the involvement of oxytocin and estrogen pathways, remain poorly understood. We investigated the effects of paternal deprivation (PD: father was removed from neonatal pups and mother alone raised the offspring) on social recognition in mandarin voles (Microtus mandarinus), a socially monogamous rodent. Paternal deprivation was found to inhibit the development of social recognition in female and male offspring according to a habituation-dishabituation paradigm. Paternal deprivation resulted in increased inactivity and reduced investigation during new encounters with other animals. Paternal deprivation reduced oxytocin receptor (OTR) and estrogen receptor α (ERα) mRNA expression in the medial amygdala and nucleus accumbens. Paternal deprivation reduced serum oxytocin (OT) concentration in females, but had no effect on males. Our results provide substantial evidence that paternal deprivation inhibits the development of social recognition in female and male mandarin voles and alters social behavior later in life. This is possibly the result of altered expression of central OTR and ERα and serum OT levels caused by paternal deprivation. Copyright © 2013 Elsevier Inc. All rights reserved.

  2. NEEM OIL ANTIFEEDANT AND INSECTICIDAL EFFECTS ON Oebalus poecilus (HEMIPTERA: PENTATOMIDAE MALES AND FEMALES EFEITO INSETICIDA E DETERRENTE DO ÓLEO DE NIM EM MACHOS E FÊMEAS DE Oebalus poecilus (HEMIPTERA: PENTATOMIDAE

    Directory of Open Access Journals (Sweden)

    Patricia Valle Pinheiro

    2010-10-01

    Full Text Available

    The antifeedant and insecticidal effects of two commercial neem (Azadirachta indica oil formulations (Dalneem and Nim-I-Go to Oebalus poecilus were evaluated on irrigated rice. To evaluate the antifeedant effect, both formulations were tested at 1% and 2% (v/v concentration levels. The insecticidal effect was evaluated at 0.5%, 1%, 2%, and 4% (v/v concentrations of Dalneem, by ingestion. Both experiments were conducted with four replications by treatment, containing one panicle and adult insects segregated by gender (two insects per plot for the antifeedant effect and five for the insecticidal effect. Both products were efficient, reducing the damage caused by insects. Insects fed less on the panicles treated with neem oil, causing lower number of feeding sheaths per panicle and lower percentage of damaged grains than the control. Spikelets weight was higher in panicles treated with neem oils. Females caused significantly higher damage than males in controls, for numbers of feeding sheaths and for the feeding deterrence index. Only at the 4% (v/v concentration level, Dalneem caused adult mortality higher than in the control. Results showed that neem oil formulations, at >= 1% (v/v concentration, can be used to reduce the quantitative and qualitative damages caused by O. poecilus in lowland rice.

    KEY-WORDS: Small rice stink bug; Azadirachta indica; qualitative damages; Oryza sativa; botanical extract.

    Avaliou-se o efeito das formulações comerciais de óleo de nim (Azadirachta indica Dalneem e Nim-I-Go sobre a alimentação e sobrevivência de O. poecilus, em arroz irrigado. O efeito sobre a alimentação foi avaliado nas concentrações de 1% e 2% (v/v das formulações. O efeito inseticida foi avaliado nas concentrações de 0,5%; 1%; 2%; e 4% (v/v de Dalneem, por ingestão. Os experimentos foram realizados com quatro repetições por tratamento, contendo uma panícula e insetos adultos separados por sexo (dois insetos por parcela, para o efeito sobre a alimentação, e cinco, para o efeito inseticida. Os dois produtos foram igualmente eficientes na redução dos danos causados pelos insetos. Os insetos alimentaram-se menos das panículas tratadas, causando menor número de bainhas de estilete/grão e menos grãos danificados do que no controle. A massa das espiguetas foi maior nas panículas tratadas. Na testemunha, as fêmeas causaram danos significativamente maiores que os machos, para número de bainhas de estilete e Índice de Deterrência da Alimentação. Apenas na concentração de 4% (v/v, o Dalneem causou mortalidade de adultos significativamente superior à da testemunha. Conclui-se que os óleos de nim testados, em concentrações >= 1% (v/v, podem ser utilizados para reduzir os danos quantitativos e qualitativos causados por O. poecilus, em arroz.

    PALAVRAS-CHAVE: Percevejo da panícula; Azadirachta indica; danos qualitativos; Oryza sativa; extrato botânico.

  3. USO DE ÓLEOS ESSENCIAIS NO CONTROLE DOS SINAIS CLÍNICOS DAS DIARREIAS NEONATAIS EM LEITÕES NASCIDOS DE FÊMEAS COM DIFERENTES ORDENS DE PARTO

    Directory of Open Access Journals (Sweden)

    Carlos Augusto Rossi

    2015-01-01

    Full Text Available This study evaluated the liquid emulsion of oregano and rosemary essential oils in the control of neonatal diarrhea in piglets. We monitored 1334 piglets with average weight of 1.5 kg regarding the clinical signs of neonatal diarrhea. The design was completely randomized with three treatments (T: (T1 control (saline, (T2 essential oils and (T3 enrofloxacin. T1 showed characteristic clinical signs of diarrhea differing (P 0.01 between piglets receiving essential oils or antibiotic, regardless of the order of parturition of the sows. On the other hand, piglets with clinical signs of diarrhea born to sows with order of parturition less than three had a higher cure rate (74.6% compared with diarrheal piglets born to sows with order of parturition between three and five (68.2% and more than five (56.4%. The counting of heter otrophic bacteria colony, Escherichia coli and Clostridium perfringens, and histological analyzes of the ileal epithelium showed no differences (P>0.01 among treatments. The emulsion with essential oils of oregano and rosemary (2mL kg-1, for piglets between zero and eight days of age, might replace the enrofloxacin in controlling clinical signs of neonatal diarrhea.

  4. DESCRIÇÃO DE DUAS TÉCNICAS CIRÚRGICAS PARA CASTRAÇÃO DE FÊMEAS BOVINAS E AVALIAÇÃO DO PÓS-OPERATÓRIO

    Directory of Open Access Journals (Sweden)

    Rogério Elias Rabelo

    2006-10-01

    Full Text Available Descrição de duas técnicas cirúrgicas de castração de fêmeas bovinas, com análise das complicações pós-operatórias, em que se utilizaram 1.232 animais de diferentes raças e idades, procedentes de várias propriedades rurais do estado de Goiás. Os bovinos foram alocados em três grupos, assim constituídos: grupo I – 436 bezerras, com idade entre oito e 12 meses, castradas via flanco; grupo II –397 novilhas e vacas, que foram esterilizadas pelo mesmo método do grupo I; grupo III – 399 vacas ovariectomizadas por via vaginal, utilizando-se o emasculador de Chassaignac.Em avaliação das técnicas cirúrgicas, concluiu-se que a castração pelo flanco foi o método de mais fácil execução e que demandou o menor tempo de transoperatório. A análise pelo teste c2 indicou que a cirurgia via vaginal implicou menos complicações pós-operatórias que a via flanco, porém levou a um maior número de óbitos. A castração via flanco é,– portanto, a técnica mais apropriada para a esterilização de fêmeas bovinas PALAVRAS-CHAVE: Ovariectomia, bovinos, pós-operatório.

  5. Identification of metabolites in urine and feces from rats dosed with the heterocyclic amine, 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA alpha C)

    DEFF Research Database (Denmark)

    Frederiksen, H.; Frandsen, Henrik Lauritz

    2004-01-01

    2-Amino-3-methyl-9H-pyrido[2,3-b]indole (MeAalphaC) is a proximate mutagenic and carcinogenic heterocyclic amine formed during ordinary cooking. In model systems, MeAalphaC can be formed by pyrolyses of either tryptophan or proteins of animal or vegetable origin. In the present study, the in vivo...

  6. Bioactivation of the heterocyclic aromatic amine 2-amino-3-methyl-9H-pyrido [2,3-b]indole (MeA alpha C) in recombinant test systems expressing human xenobiotic-metabolizing enzymes

    DEFF Research Database (Denmark)

    Glatt, H.; Pabel, U.; Meinl, W.

    2004-01-01

    2-Amino-3-methyl-9H-pyrido[2,3-b]indole (MeAalphaC) and some metabolites were investigated for mutagenicity in mammalian cell lines and bacterial strains engineered for the expression of human enzymes. MeAalphaC induced gene mutations (studied at the hprt locus) in Chinese hamster V79-derived cel...

  7. Comparison of the performance and EIS (electrochemical impedance spectroscopy) response of an activated PEMFC (proton exchange membrane fuel cell) under low and high thermal and pressure stresses

    International Nuclear Information System (INIS)

    Zhiani, Mohammad; Majidi, Somayeh; Silva, Valter Bruno; Gharibi, Hussein

    2016-01-01

    In this study, it was demonstrated that membrane electrode assembly (MEA) conditioning at the low stress condition produces a higher performance compared to MEA conditioning under the high stress condition, although it needs more time to accomplish. The maximum power density (MPD) of 1600 mW cm"−"2 was achieved by the MEA activated at low temperature and pressure (MEA-LTP) compared to the MEA activated at high temperature and pressure (MEA-HTP) in the same operating conditions, 1090 mW cm"−"2, whiles the MEA structure of both cells was identical. MEA conditioning at the low stress condition enhances not only the fuel cell power but also its energy efficiency by 25%. Comparison of electrochemical impedance spectroscopy (EIS) responses of MEA-LTP and MEA-HTP indicated that an extension of the triple phase boundary occurred in MEA-LTP, which was consistent with the results of the MEA performance analysis. - Highlights: • MEA activation at low and high P and T was studied and compared. • High steady state performance achieved by the activated MEA at low P and T. • Low R_c_t and R_m_t obtained by the activated MEA at low P and T. • Low stress condition for MEA activation is more effective than high stress status.

  8. Degradation kinetics of monoethanolamine during CO2 and H2 S absorption from biogas

    Directory of Open Access Journals (Sweden)

    Preecha Kasikamphaiboon

    2015-02-01

    Full Text Available The rate of degradation of MEA during CO2 and H2 S absorption in the biogas upgrading process was examined in four degradation systems, i.e., MEA-CO2 , MEA-CO2 -O2 , MEA-CO2 -H2 S and MEA-CO2 -O2 -H2 S. Degradation experiments were performed in a 800-ml stainless steel autoclave reactor, using MEA concentrations of 3 and 5 mol/L, CO2 loadings of 0.4 and 0.5 mol CO2 /mol MEA, O2 pressure of 200 kPa, and H2 S concentrations of 84 and 87 mg/L at temperatures of 120 and 140C. The results showed that, for the MEA-CO2 system, an increase in temperature or MEA concentration resulted in a higher rate of MEA degradation. In contrast, an increase in CO2 loading in the MEA-CO2 -O2 system led to a reduction of MEA degradation. The degradation rate of the system with O2 was with 8.3 times as high as that of the system without O2 . The presence of H2 S did not appear to affect the rate of degradation in the MEA-CO2 -H2 S system. However, for the system in which both H2 S and O2 were present, the MEA degradation was additionally induced by H2 S, thus, resulting in higher degradation rates than those of the system with O2 only. The extent of degradation under the same period of time increased in the order MEA-CO2 , MEA-CO2 -H2 S < MEA-CO2 -O2 < MEA-CO2 -O2 -H2 S.

  9. Improvement on performance and efficiency of direct methanol fuel cells using hydrocarbon-based membrane electrode assembly

    International Nuclear Information System (INIS)

    Kim, Joon-Hee; Yang, Min-Jee; Park, Jun-Young

    2014-01-01

    Highlights: • Faradaic efficiency and water transfer coefficient (WTC) of DMFC MEAs are calculated based on mass balance measurements. • Faradaic efficiency of the HC-based MEAs is generally improved over the Nafion-based MEAs. • Nafion-based MEAs show a WTC of 3, whereas the HC-based MEAs show a very low WTC of -2. • Low WTC of the HC-based MEAs indicates the back-diffusion of water from the cathode to the anode. • Performance of HC-based MEAs is improved as the fuel stoichiometry increases, maintaining high Faradaic efficiency. - Abstract: In order to improve the energy efficiency (fuel efficiency and electrical power) of direct methanol fuel cells (DMFCs), the hydrocarbon (HC) membrane-based membrane electrode assemblies (MEAs) are investigated under various operating conditions. The MEAs are then compared with the conventional Nafion-based MEA in terms of their efficiency and performance. The Faradaic efficiency and water transfer coefficient (WTC) are calculated based on mass balance measurements. The Faradaic efficiency of the HC-based MEAs is improved over the Nafion-based MEAs since methanol crossover decreased. The performance of HC-based MEAs shows strong dependency on the anode stoichiometry at high current densities probably because of the limited mass transport of fuel, which is not observed for the Nafion-based MEAs. The Nafion-based MEAs show a WTC of 3, whereas the HC-based MEAs show a very low WTC of −2, indicating the back-diffusion of water from the cathode to the anode. This may have limited mass transport by interrupting proton conduction at high current densities. The performance of HC-based MEAs at high current densities is improved as the fuel stoichiometry increases; High Faradaic efficiency is maintained by decreasing the cathode stoichiometry

  10. Low and High-Frequency Field Potentials of Cortical Networks Exhibit Distinct Responses to Chemicals

    Science.gov (United States)

    Neural networks grown on microelectrode arrays (MEAs) have become an important, high content in vitro assay for assessing neuronal function. MEA experiments typically examine high- frequency (HF) (>200 Hz) spikes, and bursts which can be used to discriminate between differ...

  11. Radiometric determination of monoethanolamine with 65ZnSo4

    International Nuclear Information System (INIS)

    Varadan, R.; Sriman Narayanan, S.; Rao, V.R.S.

    1984-01-01

    Determination of milligram amounts of monoethanolamine (MEA) with zinc(II) by radiometric titration is described. When MEA is added to a zinc(II) solution containing sulphate ions at 25 degC, a white solid complex is formed. The formation of this complex is employed for the radiometric determination of MEA with 65 Zn. The amount of MEA is directly proportional to the activity of the complex formed. The method is simple, rapid and accurate. (author)

  12. Radiometric determination of monoethanolamine with /sup 65/ZnSo/sub 4/

    Energy Technology Data Exchange (ETDEWEB)

    Varadan, R; Sriman Narayanan, S; Rao, V R.S. [Indian Inst. of Tech., Bombay. Dept. of Chemistry

    1984-05-07

    Determination of milligram amounts of monoethanolamine (MEA) with zinc(II) by radiometric titration is described. When MEA is added to a zinc(II) solution containing sulphate ions at 25 degC, a white solid complex is formed. The formation of this complex is employed for the radiometric determination of MEA with /sup 65/Zn. The amount of MEA is directly proportional to the activity of the complex formed. The method is simple, rapid and accurate. 8 refs.

  13. Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase.

    NARCIS (Netherlands)

    B.P. Engelward (Bevin); G. Weeda (Geert); M.D. Wyatt; J.L.M. Broekhof (Jose'); J. de Wit (Jan); I. Donker (Ingrid); J.M. Allan (James); B. Gold (Bert); J.H.J. Hoeijmakers (Jan); L.D. Samson (Leona)

    1997-01-01

    textabstract3-methyladenine (3MeA) DNA glycosylases remove 3MeAs from alkylated DNA to initiate the base excision repair pathway. Here we report the generation of mice deficient in the 3MeA DNA glycosylase encoded by the Aag (Mpg) gene. Alkyladenine DNA glycosylase turns out to be the major DNA

  14. Comparative study of the break in process of post doped and sol–gel high temperature proton exchange membrane fuel cells

    DEFF Research Database (Denmark)

    Vang, Jakob Rabjerg; Andreasen, Søren Juhl; Araya, Samuel Simon

    2014-01-01

    In this paper six High Temperature PEM (HTPEM) MEAs from two manufacturers have been tested. The MEAs are three Dapozol 77 from Danish Power Systems (DPS) with varying electrode composition and two Celtec P2100 and one Celtec P1000 from BASF. The break in process of the MEAs has been monitored us...

  15. Characterization of Early Cortical Neural Network Development in Multiwell Microelectrode Array Plates

    Science.gov (United States)

    We examined the development of neural network activity using microelectrode array (MEA) recordings made in multi-well MEA plates (mwMEAs) over the first 12 days in vitro (DIV). In primary cortical cultures made from postnatal rats, action potential spiking activity was essentiall...

  16. Energy optimization analysis of the more electric aircraft

    Science.gov (United States)

    Liu, Yitao; Deng, Junxiang; Liu, Chao; Li, Sen

    2018-02-01

    The More Electric Aircraft (MEA) underlines the utilization of the electrical power to drive the non-propulsive aircraft systems. The critical features of the MEA including no-bleed engine architecture and advanced electrical system are introduced. Energy and exergy analysis is conducted for the MEA, and comparison of the effectiveness and efficiency of the energy usage between conventional aircraft and the MEA is conducted. The results indicate that one of the advantages of the MEA architecture is the greater efficiency gained in terms of reduced fuel consumption.

  17. Extended UNIQUAC model for thermodynamic modeling of CO2 absorption in aqueous alkanolamine solutions

    DEFF Research Database (Denmark)

    Faramarzi, Leila; Kontogeorgis, Georgios; Thomsen, Kaj

    2009-01-01

    The extended UNIQUAC model [K. Thomsen, R Rasmussen, Chem. Eng. Sci. 54 (1999) 1787-1802] was applied to the thermodynamic representation of carbon dioxide absorption in aqueous monoethanolamine (MEA), methyldiethanolamine (MDEA) and varied strength mixtures of the two alkanolamines (MEA-MDEA). F......The extended UNIQUAC model [K. Thomsen, R Rasmussen, Chem. Eng. Sci. 54 (1999) 1787-1802] was applied to the thermodynamic representation of carbon dioxide absorption in aqueous monoethanolamine (MEA), methyldiethanolamine (MDEA) and varied strength mixtures of the two alkanolamines (MEA......) are included in the parameter estimation process. The previously unavailable standard state properties of the alkanolamine ions appearing in this work, i.e. MEA protonate, MEA carbamate and MDEA protonate are determined. The concentration of the species in both MEA and MDEA solutions containing CO2...

  18. TEORES SÉRICOS DE CORTISOL DE FÊMEAS CANINAS (Canis familiaris – LINNAEUS, 1758) SUBMETIDAS À CESARIANA SERIC LEVELS OF CORTISOL IN BITCHES (Canis familiaris – LINNAEUS, 1758) SUBMITTED TO AESARIAN SECTION Niveles séricos del cortisol en perras (Canis familiaris – Linnaeus, 1758) sometidas a cesárea

    OpenAIRE

    Diogo José Cardilli; Patrícia Rotta Lopes; Gilson Hélio Toniollo; Valeska Rodrigues; João Ademir Oliveira

    2009-01-01

    Cadelas submetidas à cesariana, por estarem em situação diferente da fisiológica, podem apresentar alterações séricas para se adaptarem a essa nova condição de estresse. Dentre as possíveis alterações, encontram-se as concentrações de cortisol durante o período periparto. Sendo assim, o objetivo deste estudo foi quantificar os teores séricos do cortisol de cadelas submetidas à cesariana na fase de parto e pós-parto (no dia do ato cirúrgico ou parto, 24 horas, 48 horas e dez dias ap...

  19. TEORES SÉRICOS DE CORTISOL DE FÊMEAS CANINAS (Canis familiaris – LINNAEUS, 1758 SUBMETIDAS À CESARIANA SERIC LEVELS OF CORTISOL IN BITCHES (Canis familiaris – LINNAEUS, 1758 SUBMITTED TO AESARIAN SECTION Niveles séricos del cortisol en perras (Canis familiaris – Linnaeus, 1758 sometidas a cesárea

    Directory of Open Access Journals (Sweden)

    Diogo José Cardilli

    2009-12-01

    Full Text Available

    Cadelas submetidas à cesariana, por estarem em situação diferente da fisiológica, podem apresentar alterações séricas para se adaptarem a essa nova condição de estresse. Dentre as possíveis alterações, encontram-se as concentrações de cortisol durante o período periparto. Sendo assim, o objetivo deste estudo foi quantificar os teores séricos do cortisol de cadelas submetidas à cesariana na fase de parto e pós-parto (no dia do ato cirúrgico ou parto, 24 horas, 48 horas e dez dias após. O método de radioimunoensaio foi utilizado para a realização da dosagem do cortisol sérico (nos períodos já descritos. Realizou-se a análise estatística por meio dos testes t e Tukey. O teor de cortisol sérico apresentou diferença (p< 0,05 no dia da cesariana (6,83 µg/dL, porém não diferiu (p> 0,05 nos dias subsequentes (1,82 µg/dL, 24 horas após; 1,38 µg/dL, 48 horas após; 1,48 µg/dL dez dias após. Os valores médios do grupo controle foram 3,43, 2,01, 3,59 e 1,72 µg/dL, após o parto, 24, 48 horas e dez dias após, respectivamente. O estresse devido à distocia elevou a liberação desse hormônio, voltando à normalidade nos dias subsequentes, porém o estresse cirúrgico não promoveu aumento na liberação de cortisol em cadelas submetidas à cesariana. Os animais do grupo controle apresentaram teores séricos de cortisol, nos devidos períodos, compatíveis com os citados pela literatura.

    PALAVRAS-CHAVES: Cadelas, cesariana, cortisol.

    Bitches submitted to caesarian section, for being in a physiological different situation, can present alterations to adapt to this new stress condition. Into possible alterations are cortisol levels during per partum period. So, the objectives of this study was to quantify seric cortisol of bitches submitted to caesarian section in partum and postpartum period (in the day of the partum or surgery , 24, 48 hours and 10 days later. The reserved serum was used to realization of cortisol measure by radioimmunoassay (on already described periods. The statistics analyzes were made by t test and Tukey. The cortisol levels presented difference (p< 0.05 in the dog of caesarian section (6.83 µg/dL but this didn’t differ (p> 0.05 on subsequent days (1.82 µg/dL, 24 hours later; 1.38 µg/dL, 48 hour later; 1.48 µg/dL, 10 days later. The middle values of control group were 3.43, 2.01, 3.59 e 1.72 µg/dL, in partum day, 24 hours later, 48 hours later and 10 days later. The stress because partum dystocic induced to liberation of cortisol, normalizing in subsequent days, but don’t have variation after cesarian (surgical stress don’t induced bigger liberation of cortisol or partum natural, composed compatible with the one found in the literature.
    KEY WORDS: Bitches, caesarian section, cortisol.
    Perras sometidas a cesárea por estar en situación distinta de la fisiológica, pueden presentar alteraciones séricas para se adaptaren a esa nueva condición de estrés. Una de las posibles alteraciones, es la concentración de cortisol durante el período peri-parto. Siendo así, el objetivo de ese estudio fue cuantificar los niveles séricos del cortisol en perras sometidas a cesárea en la fase de parto y posparto en la fase de parto y posparto (en el día del acto quirúrgico o parto, 24h, 48h y 10 días después. El método de radioinmunoensayo fue utilizado para la realización del dosaje de cortisol sérico (en los períodos ya descritos. La evaluación estadística fue realizada por medio de los testes t y Tukey. El nivel de cortisol sérico presentó diferencia (p< 0,05 en el día de la cesárea (6,83 µg/dL, pero no hubo diferencia estadística (p> 0,05 en los días consecutivos (1,82 µg/dL, 24 horas después; 1,38 µg/dL, 48 horas después; 1,48 µg/dL 10 días después. Los niveles medios del grupo control fueron 3,43, 2,01, 3,59 y 1,72 µg/dL, después del parto, 24, 48 horas y 10 días después, respectivamente. El estrés debido a la distocia elevó la liberación de esa hormona, que volvió a la normalidad en los días siguientes, pero el estrés quirúrgico no promovió aumento en la liberación de cortisol en perras sometidas a cesárea, y los animales del grupo control presentaron niveles séricos de cortisol, en los debidos períodos, de acuerdo con los descritos por la literatura.

  20. Carcass and non carcass components characteristics of lambs fed with diets containing castor mea Características da carcaça e dos componentes não-carcaça em ovinos alimentados com rações à base de farelo de mamona

    Directory of Open Access Journals (Sweden)

    Abner José Girão Meneses

    2010-03-01

    Full Text Available The objective of this work was to evaluate the effect of substitution of soybean meal by detoxified castor meal on carcass characteristics of sheep. Twenty crossbred lambs weighting 19.3 kg and averaging 7 months of age were randomly assigned to four treatments (0, 50, 75 and 100% of substitution on DN basis. The roughage used was elephant grass (Pennisetum purpureum Schum. hay. The diets were isonitrogenous and isocaloric, and fed twice daily. In the following day, orts were collected, being kept around 15%. The experiment lasted 70 days, when animals were slaughtered in a completely randomized design with four treatments and five repetitions. No significantly differences were observed among the levels of substitution for body weight (BW, weight of slaughter (WS, losses due to fasting (LDF, hot carcass weight (HCW, cold carcass weight (CCW, cooling losses (CL, length of carcass (LC, hip of perimeter (HP, hip width (HW and degree of resignation (DR. The regression analysis showed a quadratic effect for real and biological yields, with a better organic level of 100% substitution. In non carcass components, no significantly differences were registered for viscera, full gastrointestinal tract, empty gastrointestinal tract, genitals, head and legs. For the variable skin, the regression analysis showed a quadratic effect, presenting a point of maximum at 44% for replacement. The detoxified castor meal can substitute 100% of the soybean meal.Objetivou-se avaliar o efeito da substituição do farelo de soja pelo farelo de mamona destoxificado sobre as características da carcaça e dos componentes não-carcaça. Foram utilizados 20 borregos, machos, com peso vivo de 19,3kg e 7 meses de idade, distribuídos aleatoriamente em quatro tratamentos de 0, 50, 75 ou 100% de substituição, com base na matéria seca. O volumoso utilizado foi o feno de capim-elefante. As rações foram fornecidas diariamente em duas refeições e coletaram-se, no dia seguinte, as sobras, mantidas em torno de 15%. O período experimental teve duração de 70 dias, e os animais foram abatidos em seguida. Os ensaios experimentais foram realizados num delineamento inteiramente casualizado com quatro tratamentos e cinco repetições. Não foram observadas diferenças entre os níveis de substituição para peso vivo (PV, peso vivo de abate (PVA, perdas devido ao jejum (PJ, peso da carcaça quente (PCQ, peso da carcaça fria (PCF, perdas por resfriamento (PR, comprimento da carcaça (CC, perímetro da garupa (PG, largura da garupa (LG e grau de acabamento (GA. A análise de regressão revelou efeito quadrático para rendimento verdadeiro e biológico, além de ter apresentado nível biológico ótimo de 100% de substituição. Na avaliação dos componentes não-carcaça, não foram observadas diferenças para vísceras (VIS, trato gastrintestinal cheio (TGIc, trato gastrintestinal vazio (TGIv, órgãos genitais (ORG, cabeça (CAB e patas (PAT. Na variável pele (PEL, a análise de regressão revelou efeito quadrático, com nível biológico ótimo de 44% de substituição. O farelo de mamona destoxificado pode substituir em até 100% o farelo de soja.

  1. In vitro metabolism of two heterocyclic andnes, 2-amino-9H-pyrido[2,3-b]indole (A alpha C) and 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA alpha C) in human and rat hepatic microsomes

    DEFF Research Database (Denmark)

    Frederiksen, Hanne; Frandsen, Henrik Lauritz

    2002-01-01

    to two major and three minor detoxified metabolites, while MeAalphaC is metabolised to three major and one minor detoxified metabolites. Some AalphaC and MeAalphaC are activated by oxidation to the reactive metabolites N-2-OH-AalphaC and N-2-OH-MeAalphaC, respectively. These reactive N-2-OH......-metabolites react partially in the incubation system with formation of protein adducts, dimers and the parent compound by reduction of the A(2)-OH-metabolites. The distribution between the detoxified and activated metabolites in the different types of hepatic microsomes showed same pattern for both AalphaC and Mc...... and reacts to form dimers and protein adducts. These data show that, in human hepatic microsomes compared to rat hepatic microsomes, a major part of AalphaC and MeAalphaC are metabolically activated to the reactive N-2-OH-AalphaC and N-2-OH-MeAalphaC....

  2. Reconciling uncertainty of costs and outcomes with the need for access to orphan medicinal products: a comparative study of managed entry agreements across seven European countries.

    Science.gov (United States)

    Morel, Thomas; Arickx, Francis; Befrits, Gustaf; Siviero, Paolo; van der Meijden, Caroline; Xoxi, Entela; Simoens, Steven

    2013-12-24

    National payers across Europe have been increasingly looking into innovative reimbursement approaches - called managed entry agreements (MEAs) - to balance the need to provide rapid access to potentially beneficial orphan medicinal products (OMPs) with the requirements to circumscribe uncertainty, obtain best value for money or to ensure affordability. This study aimed to identify, describe and classify MEAs applied to OMPs by national payers and to analyse their practice in Europe. To identify and describe MEAs, national health technology assessments and reimbursement decisions on OMPs across seven European countries were reviewed and their main characteristics extracted. To fill data gaps and validate the accuracy of the extraction, collaboration was sought from national payers. To classify MEAs, a bespoke taxonomy was implemented. Identified MEAs were analysed and compared by focusing on five key themes, namely by describing the MEAs in relation to: drug targets and therapeutic classes, geographical spread, type of MEA applied, declared rationale for setting-up of MEAs, and evolution over time. 42 MEAs for 26 OMPs, implemented between 2006 and 2012 and representing a variety of MEA designs, were identified. Italy was the country with the highest number of schemes (n=15), followed by the Netherlands (n=10), England and Wales (n=8), Sweden (n=5) and Belgium (n=4). No MEA was identified for France and Germany due to data unavailability. Antineoplastic agents were the primary targets of MEAs. 55% of the identified MEAs were performance-based risk-sharing arrangements; the other 45% were financial-based. Nine of these 26 OMPs were subject to MEAs in two or three different countries, resulting in 24 MEAs. 60% of identified MEAs focused on conditions whose prevalence is less than 1 per 10,000. This study confirmed that a variety of MEAs were increasingly used by European payers to manage aspects of uncertainty associated with the introduction of OMPs in the healthcare

  3. Development of electrode-membrane-electrode assemblies for proton exchange membrane fuel cells (PEMFC) by Sieve printing; Desenvolvimento de conjuntos eletrodo-membrana-eletrodo para celulas a combustivel a membrana trocadora de protons (PEMFC) por impressao a tela

    Energy Technology Data Exchange (ETDEWEB)

    Andrade, Alexandre Bodart de

    2008-07-01

    The Sieve Printing process was studied in this work to apply the catalyst layers onto electrolytes utilized in PEMFC. Initially, 25 cm{sup 2} active area MEAs were built for comparison with others MEAs produced by the Spray technique. The two methods produced MEAs that showed current densities higher than 600 mA.cm{sup -2} at 600 mV. A scaling up study for 144 cm{sup 2} of active area MEAs was carried out. For this purpose, a new cell had to be projected for shelter the MEAs in such dimensions. The profile of the gas distribution channels was developed through the computational fluid dynamic tool 'Comsol Multiphysics'. For the design of the bipolar plates of the cell the 'Auto CAD' was used. The 144 cm{sup 2} MEAs made by Spray and by Sieve Printing methods were confronted with commercials MEAs ones of equal dimensions. These commercials MEAs presented better performance at 600 mV, however they were more costly than the solution developed in this study. The new method was showed to be adequate to fabricate low cost MEAs of different geometries and to produce any amount of MEAs for small scale stacks (up to 10 kW). (author)

  4. Development of electrode-membrane-electrode assemblies for proton exchange membrane fuel cells (PEMFC) by Sieve printing; Desenvolvimento de conjuntos eletrodo-membrana-eletrodo para celulas a combustivel a membrana trocadora de protons (PEMFC) por impressao a tela

    Energy Technology Data Exchange (ETDEWEB)

    Andrade, Alexandre Bodart de

    2008-07-01

    The Sieve Printing process was studied in this work to apply the catalyst layers onto electrolytes utilized in PEMFC. Initially, 25 cm{sup 2} active area MEAs were built for comparison with others MEAs produced by the Spray technique. The two methods produced MEAs that showed current densities higher than 600 mA.cm{sup -2} at 600 mV. A scaling up study for 144 cm{sup 2} of active area MEAs was carried out. For this purpose, a new cell had to be projected for shelter the MEAs in such dimensions. The profile of the gas distribution channels was developed through the computational fluid dynamic tool 'Comsol Multiphysics'. For the design of the bipolar plates of the cell the 'Auto CAD' was used. The 144 cm{sup 2} MEAs made by Spray and by Sieve Printing methods were confronted with commercials MEAs ones of equal dimensions. These commercials MEAs presented better performance at 600 mV, however they were more costly than the solution developed in this study. The new method was showed to be adequate to fabricate low cost MEAs of different geometries and to produce any amount of MEAs for small scale stacks (up to 10 kW). (author)

  5. CHARACTERISTICS OF MANAGED ENTRY AGREEMENTS IN AUSTRALIA.

    Science.gov (United States)

    Robinson, Maxine F; Mihalopoulos, Cathrine; Merlin, Tracy; Roughead, Elizabeth

    2018-01-01

    Australia relies on managed entry agreements (MEAs) for many medicines added to the national Pharmaceutical Benefits Scheme (PBS). Previous studies of Australian MEAs examined public domain documents and were not able to provide a comprehensive assessment of the types and operation of MEAs. This study used government documents approved for release to examine the implementation and administration of MEAs implemented January 2012 to May 2016. We accessed documents for medicines with MEAs on the PBS between January 2012 and May 2016. Data were extracted on Anatomical Therapeutic Classification (ATC), type of MEA (financial, financial with outcomes, outcomes, and subcategories within each group), implementation and administration methods, source of MEA recommendation, and type of economic analysis. Of all medication indication pairs (MIPs) recommended for listing, one-third had MEAs implemented. Our study of eighty-seven MIPs had 170 MEAs in place. The Government's expert health technology assessment (HTA) committee recommended MEAs for 90 percent of the eighty-seven MIPs. A total of 81 percent of MEAs were simple financial agreements: the majority either discounts (32 percent) or reimbursement caps (43 percent). Outcome-based MEAs were least common (5 percent). Ninety-two percent of MEAs were implemented and operated through legal agreements. Approximately half of the MIPs were listed on the basis of accepted claims of cost-minimization. Forty-nine percent of medicines were in ATC L group. Advice from HTA evaluations strongly influences the implementation of ways to manage uncertainties while providing access to medicines. The government relied primarily on simple financial agreements for the managed entry of medicines for which there were perceived risks.

  6. Biodegradation of alkanolamine-related wastes in bioslurries and bench-scale landfarms

    International Nuclear Information System (INIS)

    Gallagher, J.R.; Sorensen, J.A.; Knutson, R.

    1997-01-01

    The subsurface transport and fate of monoethanolamine (MEA) and its related reaction products were studied and the effectiveness of landfarming as a technique for the remediation of MEA-sludge contaminated soil was examined. MEAs are used regularly by the natural gas industry to remove hydrogen sulfide, carbon dioxide and other acid gases from natural gas. The following critical issues were examined: (1) the biodegradability of the recalcitrant fraction observed in slurry bioreactor investigations, (2) the biodegradability of selected MEA-related thermal reaction products, and (3) the effectiveness of landfarming for the remediation of MEA-contaminated soils. Key factors that may limit biodegradation of the recalcitrant fraction of organic matter in MEA wastes included inhibition due to ammonia, nutrient limitations, and insufficient time to adapt to the material and inherent resistance to biodegradation. A land treatment alternative that collects leachate for possible treatment may be the most suitable method to deal with these wastes

  7. Modeling electrochemical performance in large scale proton exchange membrane fuel cell stacks

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J H [Los Alamos National Lab., NM (United States); Lalk, T R [Texas A and M Univ., College Station, TX (United States). Dept. of Mechanical Engineering; Appleby, A J [Center for Electrochemical Studies and Hydrogen Research, Texas Engineering Experimentation Station, Texas A and M Univ., College Station, TX (United States)

    1998-02-01

    The processes, losses, and electrical characteristics of a Membrane-Electrode Assembly (MEA) of a Proton Exchange Membrane Fuel Cell (PEMFC) are described. In addition, a technique for numerically modeling the electrochemical performance of a MEA, developed specifically to be implemented as part of a numerical model of a complete fuel cell stack, is presented. The technique of calculating electrochemical performance was demonstrated by modeling the MEA of a 350 cm{sup 2}, 125 cell PEMFC and combining it with a dynamic fuel cell stack model developed by the authors. Results from the demonstration that pertain to the MEA sub-model are given and described. These include plots of the temperature, pressure, humidity, and oxygen partial pressure distributions for the middle MEA of the modeled stack as well as the corresponding current produced by that MEA. The demonstration showed that models developed using this technique produce results that are reasonable when compared to established performance expectations and experimental results. (orig.)

  8. Performance enhancement of polymer electrolyte membrane fuel cells by dual-layered membrane electrode assembly structures with carbon nanotubes.

    Science.gov (United States)

    Jung, Dong-Won; Kim, Jun-Ho; Kim, Se-Hoon; Kim, Jun-Bom; Oh, Eun-Suok

    2013-05-01

    The effect of dual-layered membrane electrode assemblies (d-MEAs) on the performance of a polymer electrolyte membrane fuel cell (PEMFC) was investigated using the following characterization techniques: single cell performance test, electrochemical impedance spectroscopy (EIS), and cyclic voltammetry (CV). It has been shown that the PEMFC with d-MEAs has better cell performance than that with typical mono-layered MEAs (m-MEAs). In particular, the d-MEA whose inner layer is composed of multi-walled carbon nanotubes (MWCNTs) showed the best fuel cell performance. This is due to the fact that the d-MEAs with MWCNTs have the highest electrochemical surface area and the lowest activation polarization, as observed from the CV and EIS test.

  9. Performance of polymer nano composite membrane electrode assembly using Alginate as a dopant in polymer electrolyte membrane fuel cell [Journal of Physics. Conference Series (Online), v. 795(1)

    International Nuclear Information System (INIS)

    Mulijani, S.

    2017-01-01

    Polymer membrane and composite polymer for membrane electrode assembly (MEAs) are synthesized and studied for usage in direct methanol fuel cell (DMFC). In this study, we prepared 3 type of MEAs, polystyrene (PS), sulfonated polystyrene (SPS) and composite polymer SPS-alginat membrane via catalyst hot pressed method. The performance and properties of prepared MEAs were evaluated and analyzed by impedance spectrometry and scanning electron microscopy (SEM). The result showed that, water up take of MEA composite polymer SPS-alginate was obtained higher than that in SPS and PS. The proton conductivity of MEA-SPS-alginate was also higher than that PS and PSS. SEM characterization revealed that the intimate contact between the carbon catalyst layers (CL) and the membranes, and the uniformly porous structure correlate positively with the MEAs prepared by hot pressed method, exhibiting high performances for DMFC. (paper)

  10. Stimulation of the medial amygdala enhances medial preoptic dopamine release: implications for male rat sexual behavior.

    Science.gov (United States)

    Dominguez, J M; Hull, E M

    2001-11-02

    Increased dopamine (DA) in the medial preoptic area (MPOA) facilitates male sexual behavior. A major source of innervation to the MPOA is the medial amygdala (MeA). We now report that chemical stimulation of the MeA enhanced levels of extracellular MPOA DA in anesthetized male rats. These results suggest that DA activity in the MPOA can be regulated by input from the MeA to the MPOA.

  11. The synthesis of alternatives for the bioconversion of waste-monoethanolamine from large-scale CO{sub 2}-removal processes

    Energy Technology Data Exchange (ETDEWEB)

    Ohtaguchi, Kazuhisa; Yokoyama, Takahisa [Tokyo Inst. of Tech. (Japan). Dept. of Chemical Engineering

    1998-12-31

    The alternatives for bioconversion of monoethanolamine (MEA), which would appear in large quantities in industrial effluent of CO{sub 2}-removal process of power companies, have been proposed by investigating the ability of some microorganisms to deaminate MEA. An evaluation of biotechnology, which includes productions from MEA of acetic acid and acetaldehyde with Escherichia coli, of formic and acetic acids with Clostridium formicoaceticum, confirms and extends our earlier remarks on availability of ecotechnology for solving the above problem. (Author)

  12. Electrochemical mass-flow control of hydrogen using a fullerene-based proton conductor

    International Nuclear Information System (INIS)

    Maruyama, Ryuichiro

    2002-01-01

    A membrane electrode assembly (MEA) was fabricated using proton conductive hydrogensulfated fullerenol (C 60 (OSO 3 H) n (OH) n ). Rate-controlled mass flow of hydrogen was performed by applying voltage to both electrodes of the MEA without humidification. The amount of the electrochemically transported hydrogen through the MEA increased as the applied current increased, obeying Faraday's law. Residual gas analysis of the transported hydrogen showed that the transported hydrogen contains trace amounts of water less than 1%

  13. Compounds of Fe-Zn bond

    International Nuclear Information System (INIS)

    Mauro, A.E.; Mancini, M.N.G.

    1981-01-01

    The compounds of the type L 1 L 2 ZnFe(CO) 4 , not yet reported, are synthesized and studied by infrared spectroscopy. The data are interpreted based on a monomeric structure with a local C sub(3v) symmetry around the iron atom. L 1 = methylamine (Mea), dimethylamine (diMea), trimethylamine (triMea) L 2 = ethylenediamine (en), N-methylethylenediamine (N,Meen), N,N-dimethylenthylenediamines, (s-diMeen). (Author) [pt

  14. Ethanolamine derivatives of dysprosium and holmium

    International Nuclear Information System (INIS)

    Gharia, K.S.; Singh, M.; Mathur, S.; Sankhla, B.S.

    1981-01-01

    The preparation and properties of dysprosium and holmium derivatives of mono-, di- and tri-ethanolamine derivatives are described. Compounds of general formulae: Ln(OPrsup(i)) 2 (mea), Ln(OPrsup(i))(mea) 2 , Ln(mea) 3 , Ln(OPrsup(i))(dea), Ln 2 (dea) 3 , Ln(dea)(deaH) and Ln(tea) (where Ln = Dy or Ho and mea, dea and tea are the anions of respective ethanolamine) were obtained and characterized by elemental analysis and IR spectra. (author)

  15. In vivo repair of methylation damage in Aag 3-methyladenine DNA glycosylase null mouse cells

    OpenAIRE

    Smith, Stephen A.; Engelward, Bevin P.

    2000-01-01

    3-Methyladenine (3MeA) DNA glycosylases initiate base excision repair by removing 3MeA. These glycosylases also remove a broad spectrum of spontaneous and environmentally induced base lesions in vitro. Mouse cells lacking the Aag 3MeA DNA glycosylase (also known as the Mpg, APNG or ANPG DNA glycosylase) are susceptible to 3MeA-induced S phase arrest, chromosome aberrations and apoptosis, but it is not known if Aag is solely responsible for repair of 3MeA in vivo. Here we show that in Aag–/– c...

  16. Anti-Diabetic Effects of Madecassic Acid and Rotundic Acid

    Directory of Open Access Journals (Sweden)

    Yuan-Man Hsu

    2015-12-01

    Full Text Available Anti-diabetic effects of madecassic acid (MEA and rotundic acid (RA were examined. MEA or RA at 0.05% or 0.1% was supplied to diabetic mice for six weeks. The intake of MEA, not RA, dose-dependently lowered plasma glucose level and increased plasma insulin level. MEA, not RA, intake dose-dependently reduced plasminogen activator inhibitor-1 activity and fibrinogen level; as well as restored antithrombin-III and protein C activities in plasma of diabetic mice. MEA or RA intake decreased triglyceride and cholesterol levels in plasma and liver. Histological data agreed that MEA or RA intake lowered hepatic lipid droplets, determined by ORO stain. MEA intake dose-dependently declined reactive oxygen species (ROS and oxidized glutathione levels, increased glutathione content and maintained the activity of glutathione reductase and catalase in the heart and kidneys of diabetic mice. MEA intake dose-dependently reduced interleukin (IL-1β, IL-6, tumor necrosis factor-α and monocyte chemoattractant protein-1 levels in the heart and kidneys of diabetic mice. RA intake at 0.1% declined cardiac and renal levels of these inflammatory factors. These data indicated that MEA improved glycemic control and hemostatic imbalance, lowered lipid accumulation, and attenuated oxidative and inflammatory stress in diabetic mice. Thus, madecassic acid could be considered as an anti-diabetic agent.

  17. GENERAL ASPECTS OF BODY MEASURES, WEIGHT AND SCORE CONDITION FEMALE NELORE BREED (Bos taurus indicus ON THE PERIOD OF 12 MONTHS ESTUDIO DE MEDIDAS CORPORALES, PESO VIVO Y CONDICIÓN CORPORAL DE BOVINOS HEMBRAS DE LA RAZA NELORE (Bos taurus indicus POR 12 MESES ESTUDO DE MEDIDAS CORPORAIS, PESO VIVO E CONDIÇÃO CORPORAL DE FÊMEAS DA RAÇA NELORE (Bos taurus indicus AO LONGO DE 12 MESES

    Directory of Open Access Journals (Sweden)

    Arcádio de Los Reys Borjas

    2008-04-01

    Full Text Available Four hundred and eighty cattle were used to verify alterations and correlations among corporal measures in Nelore zebu herd with cows and heifers. Body weight and length, corporal condition, heart girth, withers height and hip measures were evaluated. Eight collections were accomplished along the months of October of 2002 and October of 2003. In heifers there was increase of the averages of corporal measures with significant difference (p <0,05 among collections only the heart girth was different (p <0,05 in cows. The relationship between the body weight and body condition with the time were quadratic parallel curves (p <0,001. There were correlations among lineal measures body with hip measures (p<0,001 except for heart girth with hip length. The correlations of body weight and body condition among body measures were significant (p<0,001 except body condition with hip length in cows. It could be concluded that there was a growing variation of the body measures in heifers in the experimental period. The body weight, the body condition and heart girth were related with different periods of the year that the evaluation was accomplished. In cows the variations along the year were of 14,79%, 31,53% and 6,74%, respectively. The isquiun – iliun external measures, as height and width were correlated with size measures and weight. The body weight and body condition in heifers behave in way similar to cows. Further researches in relationship among body measures, body weight and body condition with productive and reproductive aspect are necessary. Con el objetivo de verificar alteraciones y correlaciones entre medidas corporales en un rebaño bovino de vaquillonas y vacas de la raza Nelore. Evaluaron-se 487 hembras en peso vivo, condición corporal, perímetro toráxico, largura corporal, altura de la cruz y medidas da anca. Fueron realizadas ocho coletas a lo largo de los meses de octubre de 2002 y octubre de 2003. En las vaquillonas hubo un aumento de las medidas corporales (p<0,05 entre colectas. Para las vacas el perímetro toráxico presentó diferencia significativa (p<0,05. La relación entre peso vivo condición corporal con el tiempo mostró ecuación cuadrática y fueron parecidas y paralelas para a condición corporal. En el peso vivo, la parte cóncava de la curva para las vacas fue mas abierta comparada a las de vaquillonas. Los coeficientes de correlación entre medidas corporales lineares con las medidas de la anca fueron elevadas (p<0,001, excepto para el perímetro toráxico con largura de la anca. Las correlaciones del peso vivo y condición corporal con medidas corporales fueron significativas (p<0,001, excepto para la condición corporal con la largura de la anca en las categorías; condición corporal versus altura de la anca y peso vivo con largura de la anca para las vacas. Como conclusiones de este trabajo: hubo una variación creciente de las medidas corporales en las vaquillonas en el período de las colecta. El peso vivo, la condición corporal y perímetro toráxico estuvieron relacionados con diferentes períodos del ano que fue realizada el experimento. En vacas las variações a lo largo de año fueron de 14,79%, 31,53% e 6,74%, respectivamente. Las medidas externas ísquio-iliacas, como altura e largura, estuvieron correlacionadas con medidas de tamaño y peso. Vaquillonas en fase de crecimiento tuvieron un comportamiento de forma análoga a las vacas con respecto al peso vivo y condición corporal. Mas investigaciones serian necesarias de las relaciones de las medidas corporales, peso vivo y condición corporal con los aspectos productivos e reproductivos. RESUMO – Objetivou-se verificar alterações e correlações entre medidas corporais em rebanho bovino de novilhas e vacas da raça Nelore. Avaliaram-se 487 fêmeas, quanto ao peso vivo, condição corporal, perímetro torácico, comprimento corporal, altura de cernelha e medidas da garupa. Foram realizadas oito coletas ao longo dos meses de outubro de 2002 e outubro de 2003. Nas novilhas houve aumento das médias de medidas corporais com diferença significativa (p<0,05 entre coletas. Para vacas o perímetro torácico apresentou diferença significativa (p<0,05. Na análise quadrática do peso vivo e condição corporal, as curvas se assemelharam, de maneira paralela para a condição corporal. Quanto ao peso vivo, a parte côncava da curva para vacas foi mais aberta comparada às novilhas. Coeficientes de correlação entre medidas lineares com medidas de garupa apresentaram significância (p<0,001, exceto para perímetro torácico com comprimento de garupa. Nas correlações do peso vivo e condição corporal com medidas corporais foram significativas (p<0,001, exceto para condição corporal versus comprimento de garupa nas categorias; condição corporal versus altura de garupa e peso vivo versus comprimento de garupa para vacas. Pode-se concluir que houve uma variação crescente das medidas corporais nas novilhas no período de coleta. O peso vivo, a condição corporal e perímetro torácico estiveram relacionados com diferentes períodos do ano que foi realizada a avaliação. Em vacas as variações ao longo do ano foram de 14,79%, 31,53% e 6,74%, respectivamente. As medidas externas ísquio-iliacas, como altura e largura, estão correlacionadas com medidas de tamanho e peso. Fêmeas em fase de crescimento comportam-se de maneira análoga às fêmeas adultas quanto ao peso vivo e condição corporal. Pesquisas da relação das medidas corporais, peso vivo e condição corporal com o aspecto produtivo e reprodutivo são necessários.

  18. High-performance membrane electrode assembly with multi-functional Pt/SnO2eSiO2/C catalyst for proton exchange membrane fuel cell operated under low-humidity conditions

    CSIR Research Space (South Africa)

    Hou, S

    2016-06-01

    Full Text Available A novel self-humidifying membrane electrode assembly (MEA) with homemade multifunctional Pt/SnO(sub2)-SiO(sub2)/C as the anode was developed to improve the performance of a proton exchange membrane fuel cell under low humidity. The MEAs' performance...

  19. CO2 recovery system using solar energy; Taiyo energy wo riyoshita CO2 bunri kaishu system

    Energy Technology Data Exchange (ETDEWEB)

    Hosho, F; Naito, H; Yugami, H; Arashi, H [Tohoku University, Sendai (Japan)

    1997-11-25

    As a part of studies on chemical absorption process with MEA (monoethanolamine) for CO2 recovery from boiler waste gas in thermal power plants, use of solar heat as MEA regenerating energy was studied. An integrated stationary evacuated concentrator (ISEC) effective as collector in a medium temperature range was used to realize a regenerating temperature range of 100-120degC. ISEC is featured by vacuum insulation, use of selective absorbing membranes for an absorber, a CPC (compound parabolic concentrator)-shaped reflection mirror, and high-efficiency. An MEA regenerator is composed of an ISEC and PG(propylene glycol)-MEA heat exchanger, and circulates PG as heat medium. Heat collection experiment was also made using water instead of MEA. Both batch and continuous systems could supply a heat quantity necessary for MEA regeneration. CO2 concentration in the top of the regenerator rapidly decreased with PG circulation regenerating MEA. As mol ratios of CO2/MEA were compared between before and after regeneration, a recovery rate was estimated to be 59.4% for the batch system. 8 figs., 4 tabs.

  20. A dynamic mathematical model for packed columns in carbon capture plants

    DEFF Research Database (Denmark)

    Gaspar, Jozsef; Jørgensen, John Bagterp; Fosbøl, Philip Loldrup

    2015-01-01

    simulation using monoethanolamine (MEA) and piperazine (PZ) as solvent. MEA is considered as the base-case solvent in the carbon capture business. The effect of changes in the flue gas flow rate and changes in the available steam are investigated to determine their influence on the performance of the capture...

  1. Fabrication of multi-emitter array of CNT for enhancement of current density

    Energy Technology Data Exchange (ETDEWEB)

    Chouhan, Vijay, E-mail: vchouhan@post.kek.jp [Department of Accelerator Science, Graduate University for Advanced Studies, 1-1 Oho, Tsukuba, Ibaraki (Japan); Noguchi, Tsuneyuki [High Energy Accelerator Research Organization-KEK, 1-1 Oho, Tsukuba, Ibaraki (Japan); Kato, Shigeki [Department of Accelerator Science, Graduate University for Advanced Studies, 1-1 Oho, Tsukuba, Ibaraki (Japan); High Energy Accelerator Research Organization-KEK, 1-1 Oho, Tsukuba, Ibaraki (Japan)

    2011-11-11

    We studied and compared field emission properties of two kinds of emitters of randomly oriented multi-wall carbon nanotubes (MWNTs), viz. continuous film emitter (CFE) and multi-emitter array (MEA). The CFE has a continuous film of MWNTs while the MEA consists of many equidistant small circular emitters. Both types of emitters were prepared by dispersing MWNTs over a titanium (Ti) film (for CFEs) or Ti circular islands (for MEAs) deposited on tantalum (Ta) followed by rooting of MWNTs into the Ti film or the Ti islands at high temperature. Emission properties of both types of emitters were analyzed with changing their emission areas. In case of the CFEs, current density decreased with an increase in emission area whereas consistent current densities were achieved from MEAs with different emission areas. In other words, the total emission current was achieved in proportion to the emission area in the case of MEAs. Additionally a high current density of 22 A/cm{sup 2} was achieved at an electric field of 8 V/{mu}m from MEAs, which was far better than that obtained from CFEs. The high current density in MEAs was attributed to edge effect, in which higher emission current is achieved from the edge of film emitter. The results indicate that the field emission characteristics can be greatly improved if a cathode contains many small equidistant circular emitters instead of a continuous film. The outstanding stability of the CFE and the MEA has been demonstrated for 2100 and 1007 h, respectively.

  2. Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-ι

    Energy Technology Data Exchange (ETDEWEB)

    Jain, Rinku; Choudhury, Jayati Roy; Buku, Angeliki; Johnson, Robert E.; Prakash, Louise; Prakash, Satya; Aggarwal, Aneel K.

    2017-03-08

    N1-methyl-deoxyadenosine (1-MeA) is formed by methylation of deoxyadenosine at the N1 atom. 1-MeA presents a block to replicative DNA polymerases due to its inability to participate in Watson-Crick (W-C) base pairing. Here we determine how human DNA polymerase-ι (Polι) promotes error-free replication across 1-MeA. Steady state kinetic analyses indicate that Polι is ~100 fold more efficient in incorporating the correct nucleotide T versus the incorrect nucleotide C opposite 1-MeA. To understand the basis of this selectivity, we determined ternary structures of Polι bound to template 1-MeA and incoming dTTP or dCTP. In both structures, template 1-MeA rotates to the syn conformation but pairs differently with dTTP versus dCTP. Thus, whereas dTTP partakes in stable Hoogsteen base pairing with 1-MeA, dCTP fails to gain a “foothold” and is largely disordered. Together, our kinetic and structural studies show how Polι maintains discrimination between correct and incorrect incoming nucleotide opposite 1-MeA in preserving genome integrity.

  3. Built-in test of electrode degradation of multi-electrode array biosensors

    NARCIS (Netherlands)

    Liu, H.Y.; Dumas, N.; Richardson, A.; Heal, R.; Kerkhoff, Hans G.

    2006-01-01

    Micro-electrode array (MEA) is a widely used platform in biosensor systems, which provide a technology in communicating with micro chemical and biological world. This paper addresses hte topic of testing micro electrode degradation for MEAs, which is a common encountered damage during its

  4. Teaching Children with Disabilities: Preparation through State Music Educators Association Conferences

    Science.gov (United States)

    VanWeelden, Kimberly; Meehan, Laura

    2016-01-01

    The purpose of this study was to determine the types and frequency of music and special education workshops held at state music educators association (MEA) conferences. Specifically, the researchers sought to determine the following within the past 10 years: (a) states that offered music and special education workshops at their MEA conferences,…

  5. CO2 Capture by Absorption with Potassium Carbonate

    Energy Technology Data Exchange (ETDEWEB)

    Gary T. Rochelle; Marcus Hilliard; Eric Chen; Babatunde Oyenekan; Ross Dugas; John McLees; Andrew Sexton; Amorvadee Veawab

    2005-01-26

    The objective of this work is to improve the process for CO{sub 2} capture by alkanolamine absorption/stripping by developing an alternative solvent, aqueous K{sub 2}CO{sub 3} promoted by piperazine. In Campaign 3 of the pilot plant, the overall mass transfer coefficient for the stripper with 7 m MEA decreased from 0.06 to 0.01 mol/(m{sup 3}.s.kPa) as the rich loading increased from 0.45 to 0.6 mol CO{sub 2}/mol MEA. Anion chromatography has demonstrated that nitrate and nitrite are major degradation products of MEA and PZ with pure oxygen. In measurements with the high temperature FTIR in 7 m MEA the MEA vapor pressure varied from 2 to 20 Pa at 35 to 70 C. In 2.5 m PZ the PZ vapor pressure varied from 0.2 to 1 Pa from 37 to 70 C.

  6. Methanol sensor operated in a passive mode

    Science.gov (United States)

    Ren, Xiaoming; Gottesfeld, Shimshon

    2002-01-01

    A sensor outputs a signal related to a concentration of methanol in an aqueous solution adjacent the sensor. A membrane electrode assembly (MEA) is included with an anode side and a cathode side. An anode current collector supports the anode side of the MEA and has a flow channel therethrough for flowing a stream of the aqueous solution and forms a physical barrier to control access of the methanol to the anode side of the MEA. A cathode current collector supports the cathode side of the MEA and is configured for air access to the cathode side of the MEA. A current sensor is connected to measure the current in a short circuit across the sensor electrodes to provide an output signal functionally related to the concentration of methanol in the aqueous solution.

  7. Using local multiplicity to improve effect estimation from a hypothesis-generating pharmacogenetics study.

    Science.gov (United States)

    Zou, W; Ouyang, H

    2016-02-01

    We propose a multiple estimation adjustment (MEA) method to correct effect overestimation due to selection bias from a hypothesis-generating study (HGS) in pharmacogenetics. MEA uses a hierarchical Bayesian approach to model individual effect estimates from maximal likelihood estimation (MLE) in a region jointly and shrinks them toward the regional effect. Unlike many methods that model a fixed selection scheme, MEA capitalizes on local multiplicity independent of selection. We compared mean square errors (MSEs) in simulated HGSs from naive MLE, MEA and a conditional likelihood adjustment (CLA) method that model threshold selection bias. We observed that MEA effectively reduced MSE from MLE on null effects with or without selection, and had a clear advantage over CLA on extreme MLE estimates from null effects under lenient threshold selection in small samples, which are common among 'top' associations from a pharmacogenetics HGS.

  8. Switch I-dependent allosteric signaling in a G-protein chaperone-B12 enzyme complex.

    Science.gov (United States)

    Campanello, Gregory C; Lofgren, Michael; Yokom, Adam L; Southworth, Daniel R; Banerjee, Ruma

    2017-10-27

    G-proteins regulate various processes ranging from DNA replication and protein synthesis to cytoskeletal dynamics and cofactor assimilation and serve as models for uncovering strategies deployed for allosteric signal transduction. MeaB is a multifunctional G-protein chaperone, which gates loading of the active 5'-deoxyadenosylcobalamin cofactor onto methylmalonyl-CoA mutase (MCM) and precludes loading of inactive cofactor forms. MeaB also safeguards MCM, which uses radical chemistry, against inactivation and rescues MCM inactivated during catalytic turnover by using the GTP-binding energy to offload inactive cofactor. The conserved switch I and II signaling motifs used by G-proteins are predicted to mediate allosteric regulation in response to nucleotide binding and hydrolysis in MeaB. Herein, we targeted conserved residues in the MeaB switch I motif to interrogate the function of this loop. Unexpectedly, the switch I mutations had only modest effects on GTP binding and on GTPase activity and did not perturb stability of the MCM-MeaB complex. However, these mutations disrupted multiple MeaB chaperone functions, including cofactor editing, loading, and offloading. Hence, although residues in the switch I motif are not essential for catalysis, they are important for allosteric regulation. Furthermore, single-particle EM analysis revealed, for the first time, the overall architecture of the MCM-MeaB complex, which exhibits a 2:1 stoichiometry. These EM studies also demonstrate that the complex exhibits considerable conformational flexibility. In conclusion, the switch I element does not significantly stabilize the MCM-MeaB complex or influence the affinity of MeaB for GTP but is required for transducing signals between MeaB and MCM. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  9. Multiple endocrine adenomatosis with Cushing's disease and the amenorrhea-galactorrhea syndrome responsive to proton beam irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Veseley, D.L.; Fass, F.H.

    1981-09-01

    Multiple endocrine adenomatosis (MEA) or neoplasia is a hereditary disorder consisting of tumors of hyperplasia of several endocrine glands. In MEA-1 the pituitary, parathyroids, and pancreatic islets are most frequently involved, while in MEA-2 the thyroid (medullary carcinoma of the thyroid), parathyroids,and adrenals (pheochromocytomas) are the endocrine glands most likely to be involved. Cushings's syndrome may occur in MEA-1 and has also been found in patients with MEA-2, where the cause of Cushing's syndrome is usually ectopic ACTH production from medullary carcinoma of the thyroid. Recently, there have been reports of amenorrhea-galactorrhea syndrome in patients with MEA-1, and confirmation that hyperprolactinemia is associated with this syndrom has been found in patients with MEA-1. The present report details a patient who has been followed up for 20 years since she first presented with amenorrhea and galactorrhea. Ten years after first being seen she was noted to have Cushing's syndrom and hyperparathyroidism due to parathyroid hyperplasia. Both the amenorrhea-galactorrhea syndrome and Cushing's sydrome disappeared with proton beam irradiation to the pituitary.

  10. Highly fluorinated comb-shaped copolymer as proton exchange membranes (PEMs): Fuel cell performance

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dae Sik; Guiver, Michael D.; Ding, Jianfu [Institute for Chemical Process and Environmental Technology, National Research Council, 1200 Montreal Road, Ottawa, Ontario K1A 0R6 (Canada); Kim, Yu.Seung; Pivovar, Bryan S. [Materials Physics and Applications, Sensors and Electrochemical Devices Group, Los Alamos National Laboratory, Los Alamos, NM 87545 (United States)

    2008-07-15

    The fuel cell performance (DMFC and H{sub 2}/air) of highly fluorinated comb-shaped copolymer is reported. The initial performance of membrane electrode assemblies (MEAs) fabricated from comb-shaped copolymer containing a side-chain weight fraction of 22% are compared with those derived from Nafion and sulfonated polysulfone (BPSH-35) under DMFC conditions. The low water uptake of comb copolymer enabled an increase in proton exchange site concentrations in the hydrated polymer, which is a desirable membrane property for DMFC application. The comb-shaped copolymer architecture induces phase separated morphology between the hydrophobic fluoroaromatic backbone and the polysulfonic acid side chains. The initial performance of the MEAs using BPSH-35 and Comb 22 copolymer were comparable and higher than that of the Nafion MEA at all methanol concentrations. For example, the power density of the MEA using Comb 22 copolymer at 350 mA cm{sup -2} and 0.5 M methanol was 145 mW cm{sup -2}, whereas the power densities of MEAs using BPSH-35 were 136 mW cm{sup -2}. The power density of the MEA using Comb 22 copolymer at 350 mA cm{sup -2} and 2.0 M methanol was 144.5 mW cm{sup -2}, whereas the power densities of MEAs using BPSH-35 were 143 mW cm{sup -2}. (author)

  11. Derivatization Ion Chromatography for the Determination of Monoethanolamine in Presence of Hydrazine in PHWR Steam-Water Circuits

    Directory of Open Access Journals (Sweden)

    Ayushi D.

    2011-01-01

    Full Text Available A simple, rapid and accurate method for the determination of monoethanolamine (MEA in PHWR steam-water circuits has been developed. MEA is added in the feed water to provide protection against corrosion while hydrazine is added to scavenge dissolved oxygen. The quantitative determination of MEA in presence of hydrazine was accomplished using derivatization ion chromatography with conductometric detection in nonsuppressed mode. A Metrosep cation 1-2 analytical column and a Metrosep cartridge were used for cation separation. A mixture of 4 mM tartaric acid, 20% acetone and 0.05 mM HNO3 was used as eluent. Acetone in the mobile phase leads to the formation of different derivatives with MEA and hydrazine. The interferences due Na+ and NH4 + were eliminated by adopting a simple pretreatment procedure employing OnGuard-H cartridge. The limit of detection limit of MEA was 0.1 μg mL−1 and the relative standard deviation was 2% for the overall method. The recovery of MEA added was in the range 95%–102%. The method was applied to the determination of MEA in steam generator water samples.

  12. Multiple endocrine adenomatosis with Cushing's disease and the amenorrhea-galactorrhea syndrome responsive to proton beam irradiation

    International Nuclear Information System (INIS)

    Veseley, D.L.; Fass, F.H.

    1981-01-01

    Multiple endocrine adenomatosis (MEA) or neoplasia is a hereditary disorder consisting of tumors of hyperplasia of several endocrine glands. In MEA-1 the pituitary, parathyroids, and pancreatic islets are most frequently involved, while in MEA-2 the thyroid (medullary carcinoma of the thyroid), parathyroids,and adrenals (pheochromocytomas) are the endocrine glands most likely to be involved. Cushings's syndrome may occur in MEA-1 and has also been found in patients with MEA-2, where the cause of Cushing's syndrome is usually ectopic ACTH production from medullary carcinoma of the thyroid. Recently, there have been reports of amenorrhea-galactorrhea syndrome in patients with MEA-1, and confirmation that hyperprolactinemia is associated with this syndrom has been found in patients with MEA-1. The present report details a patient who has been followed up for 20 years since she first presented with amenorrhea and galactorrhea. Ten years after first being seen she was noted to have Cushing's syndrom and hyperparathyroidism due to parathyroid hyperplasia. Both the amenorrhea-galactorrhea syndrome and Cushing's sydrome disappeared with proton beam irradiation to the pituitary

  13. Two DNA glycosylases in Esherichia coli which release primarily 3-methyladenine

    International Nuclear Information System (INIS)

    Thomas, L.; Yang, C.; Goldthwait, D.A.

    1982-01-01

    Two enzymes have been partially purified from Escherichia coli and designated 3-methyladenine DNA glycosylases I and II. The apparent molecular weight of glycosylase I is 20,000, and that of II is 27,000. Glycosylase I releases 3-methyladenine (3-MeA) while II releases 3-MeA, 3-methylguanine (3-MeG), 7-methylguanine (7-MeG), and 7-methyladenine (7-MeA). The rate of release of 3-MeA by glycosylase II is 30 times that of 7-MeG. Glycosylase I is missing in mutants tag 1 and tag 2. In crude extracts, the 3-MeA activity of II is approximately 10% of the total 3-MeA activity. A 50% inactivation at 48 0 C required 5 min for I and 65 min for II. The 3-MeA and 7-MeG activities of the glycosylase II preparation could not be separated by isoelectric focusing, by chromatography of DEAE, Sephadex G-100, phosphocellulose, DNA-cellulose, or carboxymethylcellulose, or by heating at 50 0 C

  14. Ice formation in PEM fuel cells operated isothermally at sub-freezing temperatures

    Energy Technology Data Exchange (ETDEWEB)

    Mukundan, Rangachary [Los Alamos National Laboratory; Luhan, Roger W [Los Alamos National Laboratory; Davey, John R [Los Alamos National Laboratory; Spendelow, Jacob S [Los Alamos National Laboratory; Borup, Rodney L [Los Alamos National Laboratory; Hussey, Daniel S [NIST; Jacobson, David L [NIST; Arif, Muhammad [NIST

    2009-01-01

    The effect of MEA and GDL structure and composition on the performance of single-PEM fuel cells operated isothermally at subfreezing temperatures is presented. The cell performance and durability are not only dependent on the MEA/GDL materials used but also on their interfaces. When a cell is operated isothermally at sub-freezing temperatures in constant current mode, the water formation due to the current density initially hydrates the membrane/ionomer and then forms ice in the catalyst layer/GDL. An increase in high frequency resistance was also observed in certain MEAs where there is a possibility of ice formation between the catalyst layer and GDL leading to a loss in contact area. The total water/ice holding capacity for any MEA was lower at lower temperatures and higher current densities. The durability of MEAs subjected to multiple isothermal starts was better for LANL prepared MEAs as compared to commercial MEAs, and cloth GDLs when compared to paper GDLs. The ice formation was monitored using high-resolution neutron radiography and was found to be concentrated near the cathode catalyst layer. However, there was significant ice formation in the GDLs especially at the higher temperature ({approx} -10 C) and lower current density (0.02 A/cm{sup 2}) operations. These results are consistent with the longer-term durability observations that show more severe degradation at the lower temperatures.

  15. [Developmental status and prospect of musical electroacupuncture].

    Science.gov (United States)

    Wang, Fan; Xu, Chun-Lan; Dong, Gui-Rong; Dong, Hong-Sheng

    2014-12-01

    Through searching domestic and foreign medical journals in CNKI, Wanfang database, VIP database and Pubmed database from January of 2003 to November of 2013, 39 articles regarding musical electroacupuncture (MEA) were analyzed. The result showed that MEA was clinically used to treat neurological and psychotic disorders; because it was combined with musical therapy and overcame the acupuncture tolerability, and MEA was superior to traditional electroacupuncture. However, problems such as low research efficiency and the mechanism of MEA superiority and the musical specificity not being revealed by research design still exist. In future, large-sample multi-center RCT researches should be performed to clarify MEA clinical efficacy. With modern science and technology and optimized study design, guided by five-element theory of TCM, researches on different musical elements and characteristics of musical pulse current as well as MEA's correlation with meridians and organs should be studied, so as to make a further exploration on MEA mechanisms and broaden the range of its clinical application.

  16. Antagonism of ascorbate against the radioprotective action of cysteamine

    Energy Technology Data Exchange (ETDEWEB)

    Naeslund, M; Ehrenberg, L; Djalali-Behzad, G [Stockholm Univ. (Sweden). Radiobiologiska Institutionen

    1976-07-01

    An investigation has been carried out into the interaction of cysteamine (MEA) and ascorbate on the radiosensitivity of E.coli, with painstaking removal of autoxidation products from glassware. Trace amounts of copper could be effectively removed, and the influence of small amounts of iron contaminating the analytical grade phosphate was assessed. The bacteria were exposed to MEA and/or ascorbate for 1 hour at 37/sup 0/C, irradiation with 42 or 58 krad of /sup 60/Co ..gamma..rays taking place 30 to 40 minutes after the additions. Survival studies demonstrated the reversion of a major fraction of the radioprotective action of MEA (2 or 6 mM) by ascorbate (5 mM) simultaneously present in the medium. Net RNA synthesis, determined by the incorporation of /sup 3/H-uridine, was suppressed by MEA and this was partly reversed by ascorbate. The irradiation of bacterium suspensions containing MEA and ascorbate was found to provoke a conspicuous stimulation of RNA synthesis above the level of unirradiated parallel samples. The effects of some oxidizing treatments (dehydroascorbic acid, hydrogen peroxide, 3.6 ..mu..M FeSO/sub 4/ or 1 ..mu..M CuSO/sub 4/) together with MEA were also studied. Possible mechanisms for the ability of ascorbate to counteract the radioprotective action of MEA are discussed, and the implication of monodehydroascorbate formed during irradiation is suggested.

  17. Long-term social recognition memory is mediated by oxytocin-dependent synaptic plasticity in the medial amygdala.

    Science.gov (United States)

    Gur, Rotem; Tendler, Alex; Wagner, Shlomo

    2014-09-01

    Recognition of specific individuals is fundamental to mammalian social behavior and is mediated in most mammals by the main and accessory olfactory systems. Both these systems innervate the medial amygdala (MeA), where activity of the neuropeptide oxytocin is thought to mediate social recognition memory (SRM). The specific contribution of the MeA to SRM formation and the specific actions of oxytocin in the MeA are unknown. We used the social discrimination test to evaluate short-term and long-term SRM in adult Sprague-Dawley male rats (n = 38). The role of protein synthesis in the MeA was investigated by local application of the protein synthesis blocker anisomycin (n = 11). Synaptic plasticity was assessed in vivo by recording the MeA evoked field potential responses to stimulation of the main (n = 21) and accessory (n = 56) olfactory bulbs before and after theta burst stimulation. Intracerebroventricular administration of saline, oxytocin, or oxytocin receptor antagonist was used to measure the effect of oxytocin on synaptic plasticity. Anisomycin application to the MeA prevented the formation of long-term SRM. In addition, the responses of MeA neurons underwent long-term depression (LTD) after theta burst stimulation of the accessory olfactory bulb, but not the main accessory bulb, in an oxytocin-dependent manner. No LTD was found in socially isolated rats, which are known to lack long-term SRM. Finally, accessory olfactory bulb stimulation before SRM acquisition blocked long-term SRM, supporting the involvement of LTD in the MeA in formation of long-term SRM. Our results indicate that long-term SRM in rats involves protein synthesis and oxytocin-dependent LTD in the MeA. Copyright © 2014 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

  18. In vitro extracellular recording and stimulation performance of nanoporous gold-modified multi-electrode arrays

    Science.gov (United States)

    Kim, Yong Hee; Kim, Gook Hwa; Kim, Ah Young; Han, Young Hwan; Chung, Myung-Ae; Jung, Sang-Don

    2015-12-01

    Objective. Nanoporous gold (Au) structures can reduce the impedance and enhance the charge injection capability of multi-electrode arrays (MEAs) used for interfacing neuronal networks. Even though there are various nanoporous Au preparation techniques, fabrication of MEA based on low-cost electro-codeposition of Ag:Au has not been performed. In this work, we have modified a Au MEA via the electro-codeposition of Ag:Au alloy, followed by the chemical etching of Ag, and report on the in vitro extracellular recording and stimulation performance of the nanoporous Au-modified MEA. Approach. Ag:Au alloy was electro-codeposited on a bilayer lift-off resist sputter-deposition passivated Au MEA followed by chemical etching of Ag to form a porous Au structure. Main results. The porous Au structure was analyzed by scanning electron microscopy and tunneling electron microscopy and found to have an interconnected nanoporous Au structure. The impedance value of the nanoporous Au-modified MEA is 15.4 ± 0.55 kΩ at 1 kHz, accompanied by the base noise V rms of 2.4 ± 0.3 μV. The charge injection limit of the nanoporous Au-modified electrode estimated from voltage transient measurement is approximately 1 mC cm-2, which is comparable to roughened platinum and carbon nanotube electrodes. The charge injection capability of the nanoporous Au-modified MEA was confirmed by observing stimulus-induced spikes at above 0.2 V. The nanoporous Au-modified MEA showed mechanical durability upon ultrasonic treatment for up to an hour. Significance. Electro-codeposition of Ag:Au alloy combined with chemical etching Ag is a low-cost process for fabricating nanoporous Au-modified MEA suitable for establishing the stimulus-response relationship of cultured neuronal networks.

  19. Effects of stabilizer ratio on photoluminescence properties of sol-gel ZnO nano-structured thin films

    International Nuclear Information System (INIS)

    Boudjouan, F.; Chelouche, A.; Touam, T.; Djouadi, D.; Khodja, S.; Tazerout, M.; Ouerdane, Y.; Hadjoub, Z.

    2015-01-01

    Nanostructured ZnO thin films with different molar ratios of MEA to zinc acetate (0.5, 1.0, 1.5 and 2.0) have been deposited on glass substrates by a sol–gel dip coating technique. X-ray diffraction, Scanning Electron Microscopy, UV–visible spectrophotometry and photoluminescence spectroscopy have been employed to investigate the effect of MEA stabilizer ratio on structural, morphological, absorbance and emission properties of the ZnO thin films. Diffraction patterns have shown that all the films are polycrystalline and exhibit a wurtzite hexagonal structure. The c axis orientation has been enhanced with increasing stabilizer ratio. SEM micrographs have revealed that the morphology of the ZnO films depend on stabilizer ratio. The UV–visible absorption spectra have demonstrated that the optical absorption is affected by stabilizer ratio. The photoluminescence spectra have indicated one ultraviolet and two visible emission bands (green and red), while band intensities are found to be dependent on stabilizer ratio. ZnO thin films deposited at MEA ratio of 1.0 show the highest UV emission while the minimum UV emission intensity is observed in thin films deposited at ratio of 0.5 and the maximum green has been recorded for films deposited at MEA ratio of 2.0. - Highlight: • c axis orientation increases with increasing MEA ratio. • The increase of MEA ration from 0.5 to 1.0 enhances greatly the UV emission. • The larger I UV /I visible is obtained for the MEA to Zn ratio of 1:1. • The MEA ratio of 0.5 favors the formation of large density of V zn . • The MEA ratio of 2.0 increases the V o density

  20. Micro-Membrane Electrode Assembly Design to Precisely Measure the in Situ Activity of Oxygen Reduction Reaction Electrocatalysts for PEMFC.

    Science.gov (United States)

    Long, Zhi; Li, Yankai; Deng, Guangrong; Liu, Changpeng; Ge, Junjie; Ma, Shuhua; Xing, Wei

    2017-06-20

    An in situ micro-MEA technique, which could precisely measure the performance of ORR electrocatalyst using Nafion as electrolyte, was designed and compared with regular thin-film rotating-disk electrode (TFRDE) (0.1 M HClO 4 ) and normal in situ membrane electrode assembly (MEA) tests. Compared to the traditional TFRDE method, the micro-MEA technique makes the acquisition of catalysts' behavior at low potential values easily achieved without being limited by the solubility of O 2 in water. At the same time, it successfully mimics the structure of regular MEAs and obtains similar results to a regular MEA, thus providing a new technique to simply measure the electrode activity without being bothered by complicated fabrication of regular MEA. In order to further understand the importance of in situ measurement, Fe-N-C as a typical oxygen reduction reaction (ORR) free-Pt catalyst was evaluated by TFRDE and micro-MEA. The results show that the half wave potential of Fe-N-C only shifted negatively by -135 mV in comparison with state-of-the-art Pt/C catalysts from TFRDE tests. However, the active site density, mass transfer of O 2 , and the proton transfer conductivity are found to strongly influence the catalyst activity in the micro-MEA, thereby resulting in a much lower limiting current density than Pt/C (8.7 times lower). Hence, it is suggested that the micro-MEA is better in evaluating the in situ ORR performance, where the catalysts are characterized more thoroughly in terms of intrinsic activity, active site density, proton transfer, and mass transfer properties.

  1. Autoinhibition and signaling by the switch II motif in the G-protein chaperone of a radical B12 enzyme.

    Science.gov (United States)

    Lofgren, Michael; Koutmos, Markos; Banerjee, Ruma

    2013-10-25

    MeaB is an accessory GTPase protein involved in the assembly, protection, and reactivation of 5'-deoxyadenosyl cobalamin-dependent methylmalonyl-CoA mutase (MCM). Mutations in the human ortholog of MeaB result in methylmalonic aciduria, an inborn error of metabolism. G-proteins typically utilize conserved switch I and II motifs for signaling to effector proteins via conformational changes elicited by nucleotide binding and hydrolysis. Our recent discovery that MeaB utilizes an unusual switch III region for bidirectional signaling with MCM raised questions about the roles of the switch I and II motifs in MeaB. In this study, we addressed the functions of conserved switch II residues by performing alanine-scanning mutagenesis. Our results demonstrate that the GTPase activity of MeaB is autoinhibited by switch II and that this loop is important for coupling nucleotide-sensitive conformational changes in switch III to elicit the multiple chaperone functions of MeaB. Furthermore, we report the structure of MeaB·GDP crystallized in the presence of AlFx(-) to form the putative transition state analog, GDP·AlF4(-). The resulting crystal structure and its comparison with related G-proteins support the conclusion that the catalytic site of MeaB is incomplete in the absence of the GTPase-activating protein MCM and therefore unable to stabilize the transition state analog. Favoring an inactive conformation in the absence of the client MCM protein might represent a strategy for suppressing the intrinsic GTPase activity of MeaB in which the switch II loop plays an important role.

  2. In vitro extracellular recording and stimulation performance of nanoporous gold-modified multi-electrode arrays.

    Science.gov (United States)

    Kim, Yong Hee; Kim, Gook Hwa; Kim, Ah Young; Han, Young Hwan; Chung, Myung-Ae; Jung, Sang-Don

    2015-12-01

    Nanoporous gold (Au) structures can reduce the impedance and enhance the charge injection capability of multi-electrode arrays (MEAs) used for interfacing neuronal networks. Even though there are various nanoporous Au preparation techniques, fabrication of MEA based on low-cost electro-codeposition of Ag:Au has not been performed. In this work, we have modified a Au MEA via the electro-codeposition of Ag:Au alloy, followed by the chemical etching of Ag, and report on the in vitro extracellular recording and stimulation performance of the nanoporous Au-modified MEA. Ag:Au alloy was electro-codeposited on a bilayer lift-off resist sputter-deposition passivated Au MEA followed by chemical etching of Ag to form a porous Au structure. The porous Au structure was analyzed by scanning electron microscopy and tunneling electron microscopy and found to have an interconnected nanoporous Au structure. The impedance value of the nanoporous Au-modified MEA is 15.4 ± 0.55 kΩ at 1 kHz, accompanied by the base noise V rms of 2.4 ± 0.3 μV. The charge injection limit of the nanoporous Au-modified electrode estimated from voltage transient measurement is approximately 1 mC cm(-2), which is comparable to roughened platinum and carbon nanotube electrodes. The charge injection capability of the nanoporous Au-modified MEA was confirmed by observing stimulus-induced spikes at above 0.2 V. The nanoporous Au-modified MEA showed mechanical durability upon ultrasonic treatment for up to an hour. Electro-codeposition of Ag:Au alloy combined with chemical etching Ag is a low-cost process for fabricating nanoporous Au-modified MEA suitable for establishing the stimulus-response relationship of cultured neuronal networks.

  3. Characterization and improvement gas diffusion layer of low temperature fuel cell; Caracterizacao e aprimoramento da camada difusora de celulas a combustivel de funcionamento a baixa temperatura

    Energy Technology Data Exchange (ETDEWEB)

    Ramos, C.Z.; Dantas, R.; Oliveira, I.S. de; Azevedo, C.M.N.; Pires, M. [Pontificia Univ. Catolica do Rio Grande do Sul (PUC-RS), Porto Alegre, RS (Brazil). Faculdade de Quimica; Canalli, V. [Pontificia Univ. Catolica do Rio Grande do Sul (PUC-RS), Porto Alegre, RS (Brazil). Faculdade de Engenharia

    2006-07-01

    In low temperature fuel cells the main part is the membrane electrode assembly (MEA). The gas diffusion layer is a component of the MEA, being a composite material constituted by carbon powder and polytetrafluoroethylene, used to increases hydrofobicity, fundamental characteristic in water transport into system. In this work methods were adapted with the aim to a better characterization of the diffusion layer by the measuring the following parameter: contact angle and hysteresis; morphology, thickness and porosity. From these characterization results optimized MEAS will be produced to better fuel cell performance. (author)

  4. The wind power prediction research based on mind evolutionary algorithm

    Science.gov (United States)

    Zhuang, Ling; Zhao, Xinjian; Ji, Tianming; Miao, Jingwen; Cui, Haina

    2018-04-01

    When the wind power is connected to the power grid, its characteristics of fluctuation, intermittent and randomness will affect the stability of the power system. The wind power prediction can guarantee the power quality and reduce the operating cost of power system. There were some limitations in several traditional wind power prediction methods. On the basis, the wind power prediction method based on Mind Evolutionary Algorithm (MEA) is put forward and a prediction model is provided. The experimental results demonstrate that MEA performs efficiently in term of the wind power prediction. The MEA method has broad prospect of engineering application.

  5. MULTILATERAL ENVIRONMENTAL AGREEMENTS AND THE TRADE MEASURES CONTAINED IN THESE AGREEMENTS

    Directory of Open Access Journals (Sweden)

    Margareta Timbur

    2012-06-01

    Full Text Available The environmental problems which the society is facing, ozone depletion, biodiversity loss, the spread of persistent organic pollutants, are a result of human activity with a worldwide impact, requiring immediate resolution. In this context, negotiation, signing and implementation of several multilateral environmental agreements (MEAs are one of the best solutions, affordable and reliable. The aim of this study is to analyze the commercial measures, which to some extent, ensure stability, security, and expansion of MEAs. The paper discusses, also, the efficiency, necessity and the influences of trade measures in MEAs and the WTO role in signing these agreements.

  6. Desenvolvimento de processo de produção de conjuntos eletrodo-membrana-eletrodo para células a combustível baseadas no uso de membrana polimérica condutora de prótons (PEMFC por impressão a tela

    Directory of Open Access Journals (Sweden)

    Rafael Nogueira Bonifácio

    2011-01-01

    Full Text Available Proton exchange membrane fuel cell (PEMFC requires membrane electrode assemblies (MEA to generate electrical energy from hydrogen and oxygen. In this study a MEA production process by sieve printing and an ink composition were developed to produce catalyst layers of MEAs. The deposition of the exact catalyst content was possible on cathodes and anodes with only one print step. The optimal ink developed shown viscosity of 2.75 Pa s, density 1.27 g cm-3, total solid content of 33.76 % and tack of 92 U.T. The electrodes prepared in only one printing step showed higher performance than those prepared in several steps.

  7. Polarization Curve of a Non-Uniformly Aged PEM Fuel Cell

    Directory of Open Access Journals (Sweden)

    Andrei Kulikovsky

    2014-01-01

    Full Text Available We develop a semi-analytical model for polarization curve of a polymer electrolyte membrane (PEM fuel cell with distributed (aged along the oxygen channel MEA transport and kinetic parameters of the membrane–electrode assembly (MEA. We show that the curve corresponding to varying along the channel parameter, in general, does not reduce to the curve for a certain constant value of this parameter. A possibility to determine the shape of the deteriorated MEA parameter along the oxygen channel by fitting the model equation to the cell polarization data is demonstrated.

  8. Fabrication of a nanosize-Pt-embedded membrane electrode assembly to enhance the utilization of Pt in proton exchange membrane fuel cells.

    Science.gov (United States)

    Choe, Junseok; Kim, Doyoung; Shim, Jinyong; Lee, Inhae; Tak, Yongsug

    2011-08-01

    A procedure to locate the Pt nanostructure inside the hydrophilic channel of a Nafion membrane was developed in order to enhance Pt utilization in PEMFCs. Nanosize Pt-embedded MEA was constructed by Cu electroless plating and subsequent Pt electrodeposition inside the hydrophilic channels of the Nafion membrane. The metallic Pt nanostructure fabricated inside the membrane was employed as an oxygen reduction catalyst for a PEMFC and facilitated effective use of the hydrophilic channels inside the membrane. Compared to the conventional MEA, a Pt-embedded MEA with only 68% Pt loading showed better PEMFC performance.

  9. Wind Turbine Power Generation Emulation Via Doubly Fed Induction Generator Control

    Science.gov (United States)

    2009-12-01

    vde thetas vqs_pu vds_pu synchronous...to stationary 0 ide_ref 200 Vdc_ref I_ref I_meas vqe PI iq I_ref I_meas vde PI id v_ref v_meas iqs PI Vdc 4 theta_s 3 ide 2 iqe 1 Vdc 21 between...1-1 x(-1)- a b a + b+ Sy stem Generator Variac P/S 60V 60HzVariac P/S 60V 60Hz 70 Vabc_s THETA CALCULATION 5 vde 4 vqe 3 Vas 2 Vdc_out 1

  10. The implementation of technical potentials by social potentials in a transition to carbon neutrality. Case study : The municipality of Pekela

    NARCIS (Netherlands)

    Cann van, Thomas

    2012-01-01

    SUMMARY The term carbon neutral has drawn more and more attention since the current worldwide climate crisis. As a reaction on this climate crisis, governments are making many large investments. Municipalities and cities are the locations where these mea

  11. Real-timing the 2010 urban mobility report.

    Science.gov (United States)

    2011-02-01

    The Texas Transportation Institute is a national leader in providing congestion and mobility : information. The Urban Mobility Report (UMR) is the most widely quoted report on urban : congestion and its associated costs in the nation. The report meas...

  12. Download this PDF file

    African Journals Online (AJOL)

    effective strategy to control the disease along with increased bio-security mea- sures to avoid .... Farland turbidity standard is comparable to contain a bacterial cells of 5x107 ..... Salmonella: laboratory aspects and epidemiological applications.

  13. Vegetation Index and Phenology (VIP) Vegetation Indices 7Days Global 0.05Deg CMG V004

    Data.gov (United States)

    National Aeronautics and Space Administration — The NASA Making Earth System Data Records for Use in Research Environments (MEaSUREs) Vegetation Index and Phenology (VIP) global datasets were created using...

  14. Vegetation Index and Phenology (VIP) Vegetation Indices Monthly Global 0.05Deg CMG V004

    Data.gov (United States)

    National Aeronautics and Space Administration — The NASA Making Earth System Data Records for Use in Research Environments (MEaSUREs) Vegetation Index and Phenology (VIP) global datasets were created using...

  15. Perioxidases play important roles in abscisic acid (ABA)-simulating ...

    African Journals Online (AJOL)

    ajl yemi

    2011-11-14

    Nov 14, 2011 ... 1Department of Plant Physiology, Slovak Agricultural University in Nitra, Tr. A. Hlinku .... Ripnany is localized in Danube uplands on clayey brown soil with ... min dark adaptation, 2) chlorophyll a fluorescence kinetics mea-.

  16. Combined ASTER and MODIS Emissivity database over Land (CAMEL) Emissivity Monthly Global 0.05Deg V001

    Data.gov (United States)

    National Aeronautics and Space Administration — The NASA Making Earth System Data Records for Use in Research Environments (MEaSUREs) Combined ASTER and MODIS Emissivity database over Land (CAMEL) dataset provides...

  17. Considerations for the implementation and operation of stormwater control measure (SCM) performance monitoring systems

    Science.gov (United States)

    Green infrastructure (GI) studies are needed to make informed decisions about whether or not to select GI technologies over traditional urban drainage control methods and to assist in the timing of effective maintenance. Two permeable pavement infiltration stormwater control meas...

  18. IKO Annual Report 1976

    International Nuclear Information System (INIS)

    1977-01-01

    The IKO Annual Report of 1976 relates their progress in different projects and project fields. The fields covered include electron scattering, pion and muon physics, theory, radio- and nuclear chemistry, technical department, MEA, nuclear reactions and nuclear spectroscopy

  19. Semi-arid Areas

    International Development Research Centre (IDRC) Digital Library (Canada)

    Livia Bizikova

    precipitation in the form of rainfall or snow (UN, 2011; MEA 2009). • Dryland subtypes can ... in terms of their land uses: rangelands, croplands, and urban areas. ... farmers; climate resilient agricultural practices; irrigation, pasture management.

  20. Global Food Security Support Analysis Data (GFSAD) Crop Mask 2010 Global 1 km V001

    Data.gov (United States)

    National Aeronautics and Space Administration — The NASA Making Earth System Data Records for Use in Research Environments (MEaSUREs) Global Food Security Support Analysis Data (GFSAD) Crop Mask Global 1 kilometer...

  1. The Case of India

    International Development Research Centre (IDRC) Digital Library (Canada)

    pwust

    based programs for Afghanistan, Bhutan, and Nepal, the MEA also funds general ... Figure 1: Organizational chart for Indian development assistance ... percent to provide loans to enable foreign governments to purchase Indian equipment and.

  2. Alternative information signs : an evaluation of driver comprehension and visual attention.

    Science.gov (United States)

    2015-08-01

    The effectiveness of a traffic sign is collectively influenced by the signs understandability, legibility distance, glance legibility, and : learnability; however, understandability has been repeatedly identified as a one of the most important mea...

  3. The Utilisation of Africa's Environmental Resources and the ...

    African Journals Online (AJOL)

    sulaiman.adebowale

    2006-05-23

    May 23, 2006 ... ment of Tanzania, one way of combating ecological and socio-economic ..... terracing, gully stabilisation, tree planting and so on as control meas- .... processes, and the current threats include housing construction, culti- vation ...

  4. Orbital Evolution and Orbital Phase Resolved Spectroscopy of the ...

    Indian Academy of Sciences (India)

    binary. We have carried out orbital phase resolved spectroscopy to mea- ... agreement with a simple model of a spherically symmetric stellar wind from the .... has a set of Narrow Field Instruments (NFI) comprising one Low Energy Concen-.

  5. Cluster-based centralized data fusion for tracking maneuvering ...

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    In this scheme, measurements are sent to the data fusion centre where the mea- ... using 'clusters' (a cluster by definition is a type of parallel or distributed processing ... working together as a single, integrated computing resource) is proposed.

  6. Performance assessments of vertically aligned carbon nanotubes multi-electrode arrays using Cath.a-differentiated (CAD) cells

    Science.gov (United States)

    Jeong, Du Won; Jung, Jongjin; Kim, Gook Hwa; Yang, Cheol-Soo; Kim, Ju Jin; Jung, Sang Don; Lee, Jeong-O.

    2015-08-01

    In this work, Cath.a-differentiated (CAD) cells were used in place of primary neuronal cells to assess the performance of vertically aligned carbon nanotubes (VACNTs) multi-electrode arrays (MEA). To fabricate high-performance MEA, VACNTs were directly grown on graphene/Pt electrodes via plasma enhanced chemical deposition technique. Here, graphene served as an intermediate layer lowering contact resistance between VACNTs and Pt electrode. In order to lower the electrode impedance and to enhance the cell adhesion, VACNTs-MEAs were treated with UV-ozone for 20 min. Impedance of VACNTs electrode at 1 kHz frequency exhibits a reasonable value (110 kΩ) for extracellular signal recording, and the signal to noise ratio the is good enough to measure low signal amplitude (15.7). Spontaneous firing events from CAD cells were successfully measured with VACNTs MEAs that were also found to be surprisingly robust toward the biological interactions.

  7. Performance assessments of vertically aligned carbon nanotubes multi-electrode arrays using Cath.a-differentiated (CAD) cells

    International Nuclear Information System (INIS)

    Jeong, Du Won; Jin Kim, Ju; Jung, Jongjin; Yang, Cheol-Soo; Lee, Jeong-O; Hwa Kim, Gook; Don Jung, Sang

    2015-01-01

    In this work, Cath.a-differentiated (CAD) cells were used in place of primary neuronal cells to assess the performance of vertically aligned carbon nanotubes (VACNTs) multi-electrode arrays (MEA). To fabricate high-performance MEA, VACNTs were directly grown on graphene/Pt electrodes via plasma enhanced chemical deposition technique. Here, graphene served as an intermediate layer lowering contact resistance between VACNTs and Pt electrode. In order to lower the electrode impedance and to enhance the cell adhesion, VACNTs-MEAs were treated with UV–ozone for 20 min. Impedance of VACNTs electrode at 1 kHz frequency exhibits a reasonable value (110 kΩ) for extracellular signal recording, and the signal to noise ratio the is good enough to measure low signal amplitude (15.7). Spontaneous firing events from CAD cells were successfully measured with VACNTs MEAs that were also found to be surprisingly robust toward the biological interactions. (paper)

  8. Enhanced performance of proton exchange membrane fuel cell by introducing nitrogen-doped CNTs in both catalyst layer and gas diffusion layer

    CSIR Research Space (South Africa)

    Hou, S

    2017-11-01

    Full Text Available The performance of the proton exchange membrane fuel cell (PEMFC) is significantly improved through introducing nitrogen-doped carbon nanotubes (NCNTs) into the catalyst layer (CL) and microporous layer (MPL) of the membrane electrode assembly (MEA...

  9. Optimization of fuel cell membrane electrode assemblies for transition metal ion-chelating ordered mesoporous carbon cathode catalysts

    Directory of Open Access Journals (Sweden)

    Johanna K. Dombrovskis

    2014-12-01

    Full Text Available Transition metal ion-chelating ordered mesoporous carbon (TM-OMC materials were recently shown to be efficient polymer electrolyte membrane fuel cell (PEMFC catalysts. The structure and properties of these catalysts are largely different from conventional catalyst materials, thus rendering membrane electrode assembly (MEA preparation parameters developed for conventional catalysts not useful for applications of TM-OMC catalysts. This necessitates development of a methodology to incorporate TM-OMC catalysts in the MEA. Here, an efficient method for MEA preparation using TM-OMC catalyst materials for PEMFC is developed including effects of catalyst/ionomer loading and catalyst/ionomer-mixing and application procedures. An optimized protocol for MEA preparation using TM-OMC catalysts is described.

  10. Investigations of the temperature distribution in proton exchange membrane fuel cells

    International Nuclear Information System (INIS)

    Jung, Chi-Young; Shim, Hyo-Sub; Koo, Sang-Man; Lee, Sang-Hwan; Yi, Sung-Chul

    2012-01-01

    A two-dimensional, non-isothermal model of a proton exchange membrane fuel cell was implemented to elucidate heat balance through the membrane electrode assembly (MEA). To take local utilization of platinum catalyst into account, the model was presented by considering the formation of agglomerated catalyst structure in the electrodes. To estimate energy balance through the MEA, various modes of heat generation and depletion by reversible/irreversible heat release, ohmic heating and phase change of water were included in the present model. In addition, dual-pathway kinetics, that is a combination of Heyrovsky–Volmer and Tafel–Volmer kinetics, were employed to precisely describe the hydrogen oxidation reaction. The proposed model was validated with experimental cell polarization, resulting in excellent fit. The temperature distribution inside the MEA was analyzed by the model. Consequently, a thorough investigation was made of the relation between membrane thickness and the temperature distribution inside the MEA.

  11. Low Frequency Activity of Cortical Networks on Microelectrode Arrays is Differentially Altered by Bicuculline and Carbaryl

    Science.gov (United States)

    Thousands of chemicals need to be characterized for their neurotoxicity potential. Neurons grown on microelectrode arrays (MEAs) are an in vitro model used to screen chemicals for functional effects on neuronal networks. Typically, after removal of low frequency components, effec...

  12. A novel CO2 sequestration system for environmentally producing hydrogen from fossil-fuels

    International Nuclear Information System (INIS)

    Eucker IV, W.

    2007-01-01

    Aqueous monoethanolamine (MEA) scrubbers are currently used to capture carbon dioxide (CO 2 ) from industrial flue gases in various fossil-fuel based energy production systems. MEA is a highly volatile, corrosive, physiologically toxic, and foul-smelling chemical that requires replacement after 1000 operational hours. Room temperature ionic liquids (RTILs), a novel class of materials with negligible vapor pressures and potentiality as benign solvents, may be the ideal replacement for MEA. Ab initio computational modeling was used to investigate the molecular interactions of ILs with CO 2 . The energetic and thermodynamic parameters of the RTILs as CO 2 solvents are on par with MEA. As viable competitors to the present CO 2 separation technology, RTILs may economize the fossil-fuel decarbonization process with the ultimate aim of realizing a green hydrogen economy

  13. Sarcopenic obesity and dyslipidemia response to selective exercise ...

    African Journals Online (AJOL)

    Maged A. Basha

    2015-01-28

    Jan 28, 2015 ... physical therapy approach in treatment of sarcopenic obesity and dyslipidemia after liver transplantation. Subjects .... fasting and were asked to empty their bladders before mea- surements. ..... RA, et al. Continuous low- to.

  14. THE MODULATED SOUNDS MADE BY THE TSETSE FLY ...

    African Journals Online (AJOL)

    11), but by conditioning them beforehand the response was improved. Since the acoustic .... had a meaJ, the abdomen was transparent and therefore contained only air. She only lived four ..... The natural history of tsetse flies. London, Lewis.

  15. Effect of cytokine-encoding plasmid delivery on immune response to Japanese encephalitis virus DNA vaccine in mice.

    Science.gov (United States)

    Bharati, Kaushik; Appaiahgari, Mohan Babu; Vrati, Sudhanshu

    2005-01-01

    We have previously shown that immunization of mice with plasmid pMEa synthesizing Japanese encephalitis virus (JEV) envelope protein induced anti-JEV humoral and cellular immune responses. We now show that intra-muscular co-administration of mice with pMEa and pGM-CSF, encoding murine granulocyte-macrophage colony-stimulating factor or pIL-2, encoding murine interleukin-2 given 4 days after pMEa, augmented anti-JEV antibody titers. This did not enhance the level of protection in immunized mice against JEV. However, intra-dermal co-administration of pMEa and pGM-CSF in mice using the gene gun, enhanced anti-JEV antibody titers resulting in an increased level of protection in mice against lethal JEV challenge.

  16. Multi-Satellite Air Quality Sulfur Dioxide (SO2) Database Long-Term L4 Global V1 (MSAQSO2L4) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — These data are a part of Multi-Decadal Sulfur Dioxide Climatology from Satellite Instrument (MEaSUREs-12-0022 project). The catalogue MSAQSO2L4 file contains the...

  17. Combined ASTER and MODIS Emissivity database over Land (CAMEL) Coefficient Monthly Global 0.05Deg V001

    Data.gov (United States)

    National Aeronautics and Space Administration — The NASA Making Earth System Data Records for Use in Research Environments (MEaSUREs) Combined ASTER and MODIS Emissivity database over Land (CAMEL) dataset provides...

  18. Diffusion Coefficients of Several Aqueous Alkanolamine Solutions

    NARCIS (Netherlands)

    Snijder, Erwin D.; Riele, Marcel J.M. te; Versteeg, Geert F.; Swaaij, W.P.M. van

    1993-01-01

    The Taylor dispersion technique was applied for the determination of diffusion coefficients of various systems. Experiments with the system KCl in water showed that the experimental setup provides accurate data. For the alkanolamines monoethanolamine (MEA), diethanolamine (DEA), methyldiethanolamine

  19. Environmental Compliance Mechanisms

    NARCIS (Netherlands)

    Merkouris, Panagiotis; Fitzmaurice, Malgosia

    2017-01-01

    Compliance mechanisms can be found in treaties regulating such diverse issues as human rights, disarmament law, and environmental law. In this bibliography, the focus will be on compliance mechanisms of multilateral environmental agreements (MEAs). Compliance with norms of international

  20. 110 C thermoluminescence glow peak of quartz – A brief review

    Indian Academy of Sciences (India)

    sitization property. Various aspects of the peak, like its nature, defect centres involved, ... sensitivity, reliability, versatility and compatibility with the detection system. Its ...... [24] H M Rendell, P D Townsend, R A Wood and B J Luff, Radiat. Meas.

  1. Surface Turbulent Fluxes, 1x1 deg Monthly Climatology, Set1 and NCEP V2c

    Data.gov (United States)

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-2c Dataset recently produced through a MEaSURES funded project led by Dr. Chung-Lin Shie...

  2. Surface Turbulent Fluxes, 1x1 deg Daily Grid, Set1 V2c

    Data.gov (United States)

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-2c (GSSTF2c) Dataset recently produced through a MEaSUREs funded project led by Dr....

  3. Surface Turbulent Fluxes, 1x1 deg Yearly Climatology, Set1 and NCEP V2c (GSSTFYC) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-2c Dataset recently produced through a MEaSURES funded project led by Dr. Chung-Lin Shie...

  4. Surface Turbulent Fluxes, 1x1 deg Monthly Climatology, Set1 and NCEP V2c (GSSTFMC) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-2c Dataset recently produced through a MEaSURES funded project led by Dr. Chung-Lin Shie...

  5. Surface Turbulent Fluxes, 1x1 deg Daily Grid, Set1 V2c (GSSTF) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-2c (GSSTF2c) Dataset recently produced through a MEaSUREs funded project led by Dr....

  6. Surface Turbulent Fluxes, 1x1 deg Monthly Grid, Set1 and Interpolated Data V2c (GSSTFM) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-2c Dataset recently produced through a MEaSUREs funded project led by Dr. Chung-Lin Shie...

  7. Surface Turbulent Fluxes, 1x1 deg Monthly Grid, Set1 and Interpolated Data V2c

    Data.gov (United States)

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-2c Dataset recently produced through a MEaSUREs funded project led by Dr. Chung-Lin Shie...

  8. Surface Turbulent Fluxes, 1x1 deg Yearly Climatology, Set1 and NCEP V2c

    Data.gov (United States)

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-2c Dataset recently produced through a MEaSURES funded project led by Dr. Chung-Lin Shie...

  9. The effect of the interaction of varying chicken manure supplement ...

    African Journals Online (AJOL)

    user

    2011-02-14

    Feb 14, 2011 ... process of food protein recovery from lignocellulosic materials ... bran, maize bran, cassava peels, carbohydrates (such as glycogen) ... Pleurotus and Agaricus species (Banik and Nandi, 2004; ... malt extract agar (MEA).

  10. Financial Reporting Procedures for Defense Distribution Depots - Defense Logistics Agency Business Area of the Defense Business Operations Fund

    National Research Council Canada - National Science Library

    Young, Shelton

    1994-01-01

    In our audit of the FY 1993 Financial Statements for the Distribution Depots--Defense Logistics Agency Business Mea of the Defense Business Operations Fund, we evaluated procedures and controls used...

  11. IKO Annual report 1979

    International Nuclear Information System (INIS)

    1980-01-01

    A review of the work performed at IKO over the past year is presented. In particular, electron scattering, muon and hadron physics, nuclear theory, radio- and nuclear chemistry, and the MEA linac. (G.T.H.)

  12. Effect of Nafion ionometer content on proton conductivity in the catalyst layer of proton exchange fuel cell

    Energy Technology Data Exchange (ETDEWEB)

    Ozalevlia, Cihan Cemil; Jian Xie; Xu, Fan [METU MS Mechanical Engineering (United States)], email: cihan.ozalevli@metu.edu.tr, email: jianxie@iupui.edu, email: fanxu@iupui.edu

    2011-07-01

    In the energy conversion sector, proton exchange fuel cells (PEFC's) are among the most promising technologies for the future. The Nafion ionometer is the most important part of the membrane electrode assembly (MEA) which is the core technology of the system. The Nafion ionometer is both a proton conductor and a binder for the catalyst layer in the technology. The aim of this study is to assess the effect of the Nafion content in the cathode catalyst layer on the proton conductivity of the MEA. Two MEAs with different Nafion content were prepared following the LANL process and the proton conductivity of the catalyst layer was measured. Results showed a much higher performance of the 28wt. % Nafion MEA than the 10wt. %. This study demonstrated that when the Nafion ionometer content decreases, the performance of the fuel cell decreases; further investigations should be undertaken with Nafion ionometer amounts of 15wt. % to 20wt. %.

  13. Advanced manufacturing of intermediate temperature, direct methane oxidation membrane electrode assemblies for durable solid oxide fuel cell, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — ITN proposes to create an innovative anode supported membrane electrode assembly (MEA) for solid oxide fuel cells (SOFCs) that is capable of long-term operation at...

  14. Study of MEH–PPV/PCBM active layer morphology and its ...

    Indian Academy of Sciences (India)

    treated with oxygen and nitrogen plasma. This treatment ... Therefore, study of hybrid polymer solar cells is becoming .... figure 1. Average contact angles were calculated from mea- .... This treatment was used to produce an ITO anode for a.

  15. Comprehensive trends assessment of nitrogen sources and loads to estuaries of the coterminous United States

    Science.gov (United States)

    Sources of nitrogen and phosphorus to estuaries and estuarine watersheds of the coterminous United States have been compiled from a variety of publically available data sources (1985 – 2015). Atmospheric loading was obtained from two sources. Modelled and interpolated meas...

  16. Surface Turbulent Fluxes, 1x1 deg Daily Grid, Satellite F15 V2c

    Data.gov (United States)

    National Aeronautics and Space Administration — These data are part of the Goddard Satellite-based Surface Turbulent Fluxes Version-2c (GSSTF 2c) Dataset recently produced through a MEaSURES funded project led by...

  17. Goddard Satellite-Based Surface Turbulent Fluxes Climatology, Yearly Grid V3

    Data.gov (United States)

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-3 Dataset recently produced through a MEaSUREs funded project led by Dr. Chung-Lin Shie...

  18. Goddard Satellite-Based Surface Turbulent Fluxes Climatology, Seasonal Grid V3

    Data.gov (United States)

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-3 Dataset recently produced through a MEaSUREs funded project led by Dr. Chung-Lin Shie...

  19. Goddard Satellite-Based Surface Turbulent Fluxes, 0.25x0.25 deg, Daily Grid, V3, (GSSTF_F14) V3

    Data.gov (United States)

    National Aeronautics and Space Administration — These data are part of the Goddard Satellite-based Surface Turbulent Fluxes Version 3 (GSSTF3) Dataset recently produced through a MEaSURES funded project led by Dr....

  20. What principles should govern the use of managed entry agreements?

    DEFF Research Database (Denmark)

    Klemp, Marianne; Frønsdal, Katrine; Facey, Karen

    2011-01-01

    BACKGROUND: To ensure rapid access to new potentially beneficial health technologies, obtain best value for money, and ensure affordability, healthcare payers are adopting a range of innovative reimbursement approaches that may be called Managed Entry Agreements (MEAs). METHODS: The Health...... Technology Assessment International (HTAi) Policy Forum sought to identify why MEAs might be used, issues associated with implementation and develop principles for their use. A 2-day deliberative workshop discussed key papers, members' experiences, and collectively addressed four policy questions...... that resulted in this study. RESULTS: MEAs are used to give access to new technologies where traditional reimbursement is deemed inappropriate. Three different forms of MEAs have been identified: management of budget impact, management of uncertainty relating to clinical and/or cost...

  1. DIAGNOSING TUBERCULOSIS IN ADULTS: OPPORTUNITIES AND ...

    African Journals Online (AJOL)

    Kurt

    2005-02-03

    Feb 3, 2005 ... and tuberculosis remains one of the most lethal infections to afflict our species. ... Hospital. He started an antiretroviral clinic at. Somerset Hospital in 2001, and in ... manager whether quality control meas- ... 1 - 9 per 100 fields.

  2. Quality Assurance Practices for the AN/FMQ-7 Optical Telescope Procurement

    National Research Council Canada - National Science Library

    1994-01-01

    ... contract quality assurance practices by the Defense Contract Management Mea Operations Dallas, Texas (DCMAO Dallas), on an Air Force contract for upgrading the Air Force's solar electro-optical network...

  3. Investigation of relationships between AIMS shape properties and VST friction values.

    Science.gov (United States)

    2015-02-01

    A thorough analysis was conducted for AIMS shape properties measured for virgin aggregates, aggregates : polished in the Micro-Deval (MD) for 105 and 210 minutes, and VST friction samples. Excellent repeatability of : AIMS angularity and texture meas...

  4. Explosive Destruction System’s Drum Filter. Part 1. Experimental Validation

    Science.gov (United States)

    2011-06-01

    test to quantify filtration performance for MEA. Being a relatively low vapor pressure chemical, MEA is strongly adsorbed by microporous adsorbents...DMMP and the nerve/HD agents I I that it simulates are strongly adsorbed by microporous adsorbents, loading on the adsorbent is relatively...is started, the challenge chemical is fed to the top of the test filter located in an insulated enclosure (9), which can be seen immediately to the

  5. Evaluation of cysticercus-specific IgG (total and subclasses and IgE antibody responses in cerebrospinal fluid samples from patients with neurocysticercosis showing intrathecal production of specific IgG antibodies

    Directory of Open Access Journals (Sweden)

    Lisandra Akemi Suzuki

    Full Text Available In the present study, an enzyme-linked immunosorbent assay (ELISA standardized with vesicular fluid of Taenia solium cysticerci was used to screen for IgG (total and subclasses and IgE antibodies in cerebrospinal fluid (CSF samples from patients with neurocysticercosis showing intrathecal production of specific IgG antibodies and patients with other neurological disorders. The following results were obtained: IgG-ELISA: 100% sensitivity (median of the ELISA absorbances (MEA=1.17 and 100% specificity; IgG1-ELISA: 72.7% sensitivity (MEA=0.49 and 100% specificity; IgG2-ELISA: 81.8% sensitivity (MEA=0.46 and 100% specificity; IgG3-ELISA: 63.6% sensitivity (MEA=0.12 and 100% specificity; IgG4-ELISA: 90.9% sensitivity (MEA=0.85 and 100% specificity; IgE-ELISA 93.8% sensitivity (MEA=0.60 and 100% specificity. There were no significant differences between the sensitivities and specificities in the detection of IgG-ELISA and IgE-ELISA, although in CSF samples from patients with neurocysticercosis the MEA of the IgG-ELISA was significantly higher than that of the IgE-ELISA. The sensitivity and MEA values of the IgG4-ELISA were higher than the corresponding values for the other IgG subclasses. Future studies should address the contribution of IgG4 and IgE antibodies to the physiopathology of neurocysticercosis.

  6. Nanofiber membrane-electrode-assembly and method of fabricating same

    Energy Technology Data Exchange (ETDEWEB)

    Pintauro, Peter N.; Ballengee, Jason; Brodt, Matthew

    2018-01-23

    In one aspect of the present invention, a method of fabricating a fuel cell membrane-electrode-assembly (MEA) having an anode electrode, a cathode electrode, and a membrane disposed between the anode electrode and the cathode electrode, includes fabricating each of the anode electrode, the cathode electrode, and the membrane separately by electrospinning; and placing the membrane between the anode electrode and the cathode electrode, and pressing then together to form the fuel cell MEA.

  7. Polyarylenethioethersulfone Membranes for Fuel Cells (Postprint)

    Science.gov (United States)

    2010-01-01

    The Electrochemical SocietyProton exchange membrane fuel cells PEMFCs are an attrac- tive power source due to their energy efficiency and...standard in PEMFC technology.3,4 Nafion membranes have a polytetrafluoro- ethylene PTFE backbone, which provides thermal and chemical stability, and...diffusion layers to fabricate MEAs. Single-cell test (H- PEMFC ).— MEAs were positioned in a single-cell fixture with graphite blocks as current

  8. Assessment of Platelet Function in Traumatic Brain Injury-A Retrospective Observational Study in the Neuro-Critical Care Setting.

    Science.gov (United States)

    Lindblad, Caroline; Thelin, Eric Peter; Nekludov, Michael; Frostell, Arvid; Nelson, David W; Svensson, Mikael; Bellander, Bo-Michael

    2018-01-01

    Despite seemingly functional coagulation, hemorrhagic lesion progression is a common and devastating condition following traumatic brain injury (TBI), stressing the need for new diagnostic techniques. Multiple electrode aggregometry (MEA) measures platelet function and could aid in coagulopathy assessment following TBI. The aims of this study were to evaluate MEA temporal dynamics, influence of concomitant therapy, and its capabilities to predict lesion progression and clinical outcome in a TBI cohort. Adult TBI patients in a neurointensive care unit that underwent MEA sampling were retrospectively included. MEA was sampled if the patient was treated with antiplatelet therapy, bled heavily during surgery, or had abnormal baseline coagulation values. We assessed platelet activation pathways involving the arachidonic acid receptor (ASPI), P2Y 12 receptor, and thrombin receptor (TRAP). ASPI was the primary focus of analysis. If several samples were obtained, they were included. Retrospective data were extracted from hospital charts. Outcome variables were radiologic hemorrhagic progression and Glasgow Outcome Scale assessed prospectively at 12 months posttrauma. MEA levels were compared between patients on antiplatelet therapy. Linear mixed effect models and uni-/multivariable regression models were used to study longitudinal dynamics, hemorrhagic progression and outcome, respectively. In total, 178 patients were included (48% unfavorable outcome). ASPI levels increased from initially low values in a time-dependent fashion ( p  trend of MEA is identified in this TBI cohort, even in patients without known antiplatelet therapies. Values appear also affected by platelet inhibitory treatment and by platelet transfusions. While significant in univariate models to predict outcome, MEA values did not independently correlate to outcome or lesion progression in multivariable analyses. Further prospective studies to monitor coagulation in TBI patients are warranted, in

  9. Transfusion requirements in elective cardiopulmonary bypass surgery patients

    DEFF Research Database (Denmark)

    Sivapalan, Praleene; Bäck, Anne Caroline; Ostrowski, Sisse Rye

    2017-01-01

    Managing haemostasis in patients undergoing cardiopulmonary bypass (CPB) surgery remains a challenge. There is no established laboratory test to predict transfusion requirements in cardiac surgery. We investigated whether preoperative Thromboelastography (TEG) with Platelet Mapping Assay (PMA......) or Multiple Electrode Aggrometry (MEA) could predict transfusion requirements in patients undergoing elective coronary artery bypass grafting (CABG) or combined CABG with aortic or mitral valve replacement. We prospectively investigated 199 patients undergoing elective CABG or combined procedures. PMA and MEA...

  10. Oxytocin signaling in the medial amygdala is required for sex discrimination of social cues

    OpenAIRE

    Yao, Shenqin; Bergan, Joseph; Lanjuin, Anne; Dulac, Catherine

    2017-01-01

    The neural control of social behaviors in rodents requires the encoding of pheromonal cues by the vomeronasal system. Here we show that the typical preference of male mice for females is eliminated in mutants lacking oxytocin, a neuropeptide modulating social behaviors in many species. Ablation of the oxytocin receptor in aromatase-expressing neurons of the medial amygdala (MeA) fully recapitulates the elimination of female preference in males. Further, single-unit recording in the MeA uncove...

  11. Oxytocin Signaling in the Medial Amygdala is required for Sex Discrimination of Social Cues

    OpenAIRE

    Bergan, Joseph; Yao, Shenqin; Lanjuin, Anne; Dulac, Catherine

    2017-01-01

    The neural control of social behaviors in rodents requires the encoding of pheromonal cues by the vomeronasal system. Here we show that the typical preference of male mice for females is eliminated in mutants lacking oxytocin, a neuropeptide modulating social behaviors in many species. Ablation of the oxytocin receptor in aromatase expressing neurons of the medial amygdala (MeA) fully recapitulates the elimination of female preference in males. Further, single unit recording in the MeA uncove...

  12. Development of a membrane electrode as assembly production process for proton exchange membrane fuel cell (PEMFC) by sieve printing; Desenvolvimento de processo de producao de conjuntos eletrodo-membrana-eletrodo para celulas a combustivel baseadas no uso de membrana polimerica conditora de protons (PEMFC) por impressa a tela

    Energy Technology Data Exchange (ETDEWEB)

    Bonifacio, Rafael Nogueira

    2010-07-01

    Energy is a resource that presents historical trend of growth in demand. Projections indicate that future energy needs will require a massive use of hydrogen as fuel. The use of systems based on the use of proton exchange membrane fuel cell (PEMFC) has features that allow its application for stationary applications, automotive and portable power generation. The use of hydrogen as fuel for PEMFC has the advantage low pollutants' emission, when compared to fossil fuels. For the reactions in a PEMFC is necessary to build membrane electrode assembly (MEA). And the production of MEAs and its materials are relevant to the final cost of k W of power generated by systems of fuel cell. This represent currently a technological and financial barriers to large-scale application of this technology. In this work a process of MEAs fabrication were developed that showed high reproducibility, rapidity and low cost by sieve printing. The process of sieve printing and the ink composition as a precursor to the catalyst layer were developed, which allow the preparation of electrodes for MEAs fabrication with the implementation of the exact catalyst loading, 0.6 milligrams of platinum per square centimeters (mgPt.cm{sup -2}) suitable for cathodes and 0.4 mgPt.cm{sup -2} for anode in only one application step per electrode. The ink was developed, produced, characterized and used with similar characteristics to ink of sieve printing build for other applications. The MEAs produced had a performance of up to 712 m A.cm{sup -2} by 600 mV to 25 cm{sup 2} MEA area. The MEA cost production for MEAs of 247.86 cm{sup 2}, that can generate 1 kilowatt of energy was estimated to US$ 7,744.14 including cost of equipment, materials and labor. (author)

  13. Process for recycling components of a PEM fuel cell membrane electrode assembly

    Science.gov (United States)

    Shore, Lawrence [Edison, NJ

    2012-02-28

    The membrane electrode assembly (MEA) of a PEM fuel cell can be recycled by contacting the MEA with a lower alkyl alcohol solvent which separates the membrane from the anode and cathode layers of the assembly. The resulting solution containing both the polymer membrane and supported noble metal catalysts can be heated under mild conditions to disperse the polymer membrane as particles and the supported noble metal catalysts and polymer membrane particles separated by known filtration means.

  14. Development of a membrane electrode assembly production process for proton exchange membrane fuel cell (PEMFC) by sieve printing

    International Nuclear Information System (INIS)

    Bonifacio, Rafael Nogueira

    2010-01-01

    Energy is a resource that presents historical trend of growth in demand. Projections indicate that future energy needs will require a massive use of hydrogen as fuel. The use of systems based on the use of proton exchange membrane fuel cell (PEMFC) has features that allow its application for stationary applications, automotive and portable power generation. The use of hydrogen as fuel for PEMFC has the advantage low pollutants' emission, when compared to fossil fuels. For the reactions in a PEMFC is necessary to build membrane electrode assembly (MEA). And the production of MEAs and its materials are relevant to the final cost of kW of power generated by systems of fuel cell. This represent currently a technological and financial barriers to large-scale application of this technology. In this work a process of MEAs fabrication were developed that showed high reproducibility, rapidity and low cost by sieve printing. The process of sieve printing and the ink composition as a precursor to the catalyst layer were developed, which allow the preparation of electrodes for MEAs fabrication with the implementation of the exact catalyst loading, 0.6 milligrams of platinum per square centimeters (mgPt.cm -2 ) suitable for cathodes and 0.4 mgPt.cm -2 for anode in only one application step per electrode. The ink was developed, produced, characterized and used with similar characteristics to ink of sieve printing build for other applications. The MEAs produced had a performance of up to 712 mA.cm -2 by 600 mV to 25 cm 2 MEA area. The MEA cost production for MEAs of 247.86 cm 2 , that can generate 1 kilowatt of energy was estimated to US$ 7,744.14 including cost of equipment, materials and labor. (author)

  15. What principles should govern the use of managed entry agreements?

    Science.gov (United States)

    Klemp, Marianne; Frønsdal, Katrine B; Facey, Karen

    2011-01-01

    To ensure rapid access to new potentially beneficial health technologies, obtain best value for money, and ensure affordability, healthcare payers are adopting a range of innovative reimbursement approaches that may be called Managed Entry Agreements (MEAs). The Health Technology Assessment International (HTAi) Policy Forum sought to identify why MEAs might be used, issues associated with implementation and develop principles for their use. A 2-day deliberative workshop discussed key papers, members' experiences, and collectively addressed four policy questions that resulted in this study. MEAs are used to give access to new technologies where traditional reimbursement is deemed inappropriate. Three different forms of MEAs have been identified: management of budget impact, management of uncertainty relating to clinical and/or cost-effectiveness, and management of utilization to optimize performance. The rationale for using these approaches and their advantages and disadvantages differ. However, all forms of MEA should take the form of a formal written agreement among stakeholders, clearly identifying the rationale for the agreement, aspects to be assessed, methods of data collection and review, and the criteria for ending the agreement. MEAs should only be used when HTA identifies issues or concerns about key outcomes and/or costs and/or organizational/budget impacts that are material to a reimbursement decision. They provide patient access and can be useful to manage technology diffusion and optimize use. However, they are administratively complex and may be difficult to negotiate and their effectiveness has yet to be evaluated.

  16. Phosphoric acid distribution in the membrane electrode assembly of high temperature proton exchange membrane fuel cells

    International Nuclear Information System (INIS)

    Kwon, Kyungjung; Park, Jung Ock; Yoo, Duck Young; Yi, Jung S.

    2009-01-01

    The ionomer content in electrode is one of the most important parameters for the high performance of fuel cells. The high temperature PEMFC based on phosphoric acid (PA)-doped polymer membrane with unhumidified reactant gases has a difficulty in controlling the liquid state PA ionomer content in electrode. To evaluate the PA content in electrode, the three techniques of cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and acid-base titration (ABT) are carried out in situ or ex situ. The properties of membrane electrode assembly (MEA) such as electrochemical surface area (ESA), ohmic resistance, charge transfer resistance, double layer capacitance and the amount of PA in MEA components (anode, cathode and membrane) are extracted by each technique. Ex situ CV with the usage of dry gases has a limitation in assessing the reliable ESA of unhumidified PEMFC. While in situ EIS presents some informative values of resistance and capacitance for understanding the PA distribution in MEA, its sensitivity to the PA content in MEA components needs to be higher for detecting a subtle change in PA distribution. Ex situ ABT supplies a clear PA distribution in MEA at room temperature but does not seem to reflect the operating state well at high temperatures. However, it can be used as a detection tool for the loss of the initial acid content in membrane during a long-term MEA durability study.

  17. Water Transport and Removal in PEMFC Gas Flow Channel with Various Water Droplet Locations and Channel Surface Wettability

    Directory of Open Access Journals (Sweden)

    Yanzhou Qin

    2018-04-01

    Full Text Available Water transport and removal in the proton exchange membrane fuel cell (PEMFC is critically important to fuel cell performance, stability, and durability. Water emerging locations on the membrane-electrode assembly (MEA surface and the channel surface wettability significantly influence the water transport and removal in PEMFC. In most simulations of water transport and removal in the PEMFC flow channel, liquid water is usually introduced at the center of the MEA surface, which is fortuitous, since water droplet can emerge randomly on the MEA surface in PEMFC. In addition, the commonly used no-slip wall boundary condition greatly confines the water sliding features on hydrophobic MEA/channel surfaces, degrading the simulation accuracy. In this study, water droplet is introduced with various locations along the channel width direction on the MEA surface, and water transport and removal is investigated numerically using an improved model incorporating the sliding flow property by using the shear wall boundary condition. It is found that the water droplet can be driven to the channel sidewall by aerodynamics when the initial water location deviates from the MEA center to a certain amount, forming the water corner flow in the flow channel. The channel surface wettability on the water transport is also studied and is shown to have a significant impact on the water corner flow in the flow channel.

  18. Phosphoric acid distribution in the membrane electrode assembly of high temperature proton exchange membrane fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Kyungjung [Fuel Cell Group, Energy Lab, SAIT, Samsung Electronics Co., Ltd., San 14-1, Nongseo-dong, Giheung-gu, Yongin-si, Gyeonggi-do, 446-712 (Korea, Republic of)], E-mail: kfromberk@gmail.com; Park, Jung Ock; Yoo, Duck Young; Yi, Jung S. [Fuel Cell Group, Energy Lab, SAIT, Samsung Electronics Co., Ltd., San 14-1, Nongseo-dong, Giheung-gu, Yongin-si, Gyeonggi-do, 446-712 (Korea, Republic of)

    2009-11-01

    The ionomer content in electrode is one of the most important parameters for the high performance of fuel cells. The high temperature PEMFC based on phosphoric acid (PA)-doped polymer membrane with unhumidified reactant gases has a difficulty in controlling the liquid state PA ionomer content in electrode. To evaluate the PA content in electrode, the three techniques of cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and acid-base titration (ABT) are carried out in situ or ex situ. The properties of membrane electrode assembly (MEA) such as electrochemical surface area (ESA), ohmic resistance, charge transfer resistance, double layer capacitance and the amount of PA in MEA components (anode, cathode and membrane) are extracted by each technique. Ex situ CV with the usage of dry gases has a limitation in assessing the reliable ESA of unhumidified PEMFC. While in situ EIS presents some informative values of resistance and capacitance for understanding the PA distribution in MEA, its sensitivity to the PA content in MEA components needs to be higher for detecting a subtle change in PA distribution. Ex situ ABT supplies a clear PA distribution in MEA at room temperature but does not seem to reflect the operating state well at high temperatures. However, it can be used as a detection tool for the loss of the initial acid content in membrane during a long-term MEA durability study.

  19. Theoretical effect of concentration, circulation rate, stages, pressure and temperature of single amine and amine mixture solvents on gas sweetening performance

    Directory of Open Access Journals (Sweden)

    Nilay Kumar Sarker

    2016-09-01

    Full Text Available This simulation experiment performed by Aspen Hysys is about theoretical investigation of gas sweetening performance of single amine solvents MEA1, MDEA2, DEA3, DGA4, DIPA5 and mixed amine solvents DGA–MEA, DEA–MDEA and SULFOLANE6–MDEA. Sweet gas having very high percentage of methane is produced by MEA (95.36%, DGA–MEA (95.37%, DEA–MDEA (95.51% and SULFOLANE–MDEA (95.10% and DGA (93.76% shows lowest performance. DGA, SULFOLANE–MDEA, MDEA remove H2S at a lower circulation rate and DEA, DIPA need higher but satisfactory circulation rate. Increasing stage number shows positive effect on DEA, DIPA and SULFOLANE–MDEA. Pressure change has no significant effect. Temperature increase and methane percentage are negatively correlated for all solvents (except low circulating DIPA. With temperature increase H2S composition increases for DEA–MDEA, DGA–MEA; CO2 increases for DEA–MDEA, DGA–MEA and high circulating SULFOLANE–MDEA.

  20. Performance enhancement of membrane electrode assemblies with plasma etched polymer electrolyte membrane in PEM fuel cell

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Yong-Hun; Yoon, Won-Sub [School of Advanced Materials Engineering, Kookmin University, 861-1 Jeongneung-dong, Seongbuk-gu, Seoul 136-702 (Korea); Bae, Jin Woo; Cho, Yoon-Hwan; Lim, Ju Wan; Ahn, Minjeh; Jho, Jae Young; Sung, Yung-Eun [World Class University (WCU) program of Chemical Convergence for Energy and Environment (C2E2), School of Chemical and Biological Engineering, College of Engineering, Seoul National University (SNU), 599 Gwanak-Ro, Gwanak-gu, Seoul 151-744 (Korea); Kwon, Nak-Hyun [Fuel Cell Vehicle Team 3, Advanced Technology Center, Corporate Research and Development Division, Hyundai-Kia Motors, 104 Mabuk-dong, Giheung-gu, Yongin-si, Gyeonggi-do 446-912 (Korea)

    2010-10-15

    In this work, a surface modified Nafion 212 membrane was fabricated by plasma etching in order to enhance the performance of a membrane electrode assembly (MEA) in a polymer electrolyte membrane fuel cell. Single-cell performance of MEA at 0.7 V was increased by about 19% with membrane that was etched for 10 min compared to that with untreated Nafion 212 membrane. The MEA with membrane etched for 20 min exhibited a current density of 1700 mA cm{sup -2} at 0.35 V, which was 8% higher than that of MEA with untreated membrane (1580 mA cm{sup -2}). The performances of MEAs containing etched membranes were affected by complex factors such as the thickness and surface morphology of the membrane related to etching time. The structural changes and electrochemical properties of the MEAs with etched membranes were characterized by field emission scanning electron microscopy, Fourier transform-infrared spectrometry, electrochemical impedance spectroscopy, and cyclic voltammetry. (author)

  1. Effect of Modifying Factors on Radiosensitive Biochemical Reactions

    Energy Technology Data Exchange (ETDEWEB)

    Romantsev, E. F.; Filippovich, I. V.; Zhulanova, Z. I.; Blokhina, V. D.; Trebenok, Z. A.; Kolesnikov, E. E.; Sheremetyevskaya, T. N.; Nikolsky, A. V.; Zymaleva, O. G. [Institute of Biophysics, USSR Ministry of Health, Moscow, USSR (Russian Federation)

    1971-03-15

    Some of the radioprotective aminothiols are now routine pharmacopoeial drugs and are used in clinics to decrease the radiation reaction which appears as a side effect during the radiotherapy of cancer. The action of effective modifying agents on radiosensitive biochemical reactions in the organisms of mammals, in principle, cannot be different from the same effects of the protectors on biochemical systems of the human organism. The effect of modifying agents is mediated by biochemical systems. The administration of radioprotective doses of MEA to rats before irradiation results in a significant normalization of the excretion in urine of degradation products of nucleic acids (so-called Dische-positive compounds), the excretion of which sharply rises after irradiation. The curve of the radioprotective effect of MEA (survival rate after administration of radioprotectors at different intervals of time) completely corresponds to curves of the accumulation of MEA which is bound (by mixed disulphide links) to the proteins of liver mitochondria, to proteins of the nuclear-sap, to the hyaloplasm of rat thymus and to the nuclear ribosomes of the spleen. After MEA administration the curve of the biosynthesis of deoxycytidine represents a mirror reflection of the curve of MEA bound to proteins of the thymus hyaloplasm by means of mixed disulphide links. The mechanism of action of such modifying factors as MEA in experiments on mammals is mediated to a great degree through the temporary formation of mixed disulphide links between the aminothiol and the protein component of enzymes in different biochemical systems. (author)

  2. Effect of adding unconventional raw materials on the technological properties of rice fresh pasta

    Directory of Open Access Journals (Sweden)

    Meg da Silva Fernandes

    2013-06-01

    Full Text Available The aim of this study was to develop fettuccini type rice fresh pasta by cold extrusion. To produce the pasta, a 2² Central Composite Rotational Design was used, in which the effects of the addition of pre-gelatinized rice flour - PGRF (0-60% and modified egg albumin - MEA (0-10% were studied. The dependent variables were the results of the cooking test and of the instrumental texture. The optimum cooking time for all of the formulations of rice fresh pasta was 3 minutes. MEA had a greater effect on increasing the weight of the pasta when compared to that of PGRF. It was found that with the addition of PGRF increase in loss of solids in cooking water, whereas MEA exerted the opposite effect on this parameter. Moreover, the maximum value of MEA (10% had an optimum effect on pasta firmness, while PGRF had a negative effect on this parameter. The maximum values of PGRF and MEA reduced the stickiness of the pasta. Based on these results and on the parameters considered as most important, the rice pasta with the best technological characteristics was that with the maximum levels of MEA (10% and no addition of PGRF (0%. This product was submitted to sensory and microbiological analyses, with good results.

  3. A Low-Noise, Modular, and Versatile Analog Front-End Intended for Processing In Vitro Neuronal Signals Detected by Microelectrode Arrays

    Directory of Open Access Journals (Sweden)

    Giulia Regalia

    2015-01-01

    Full Text Available The collection of good quality extracellular neuronal spikes from neuronal cultures coupled to Microelectrode Arrays (MEAs is a binding requirement to gather reliable data. Due to physical constraints, low power requirement, or the need of customizability, commercial recording platforms are not fully adequate for the development of experimental setups integrating MEA technology with other equipment needed to perform experiments under climate controlled conditions, like environmental chambers or cell culture incubators. To address this issue, we developed a custom MEA interfacing system featuring low noise, low power, and the capability to be readily integrated inside an incubator-like environment. Two stages, a preamplifier and a filter amplifier, were designed, implemented on printed circuit boards, and tested. The system is characterized by a low input-referred noise (70 dB, and signal-to-noise ratio values of neuronal recordings comparable to those obtained with the benchmark commercial MEA system. In addition, the system was successfully integrated with an environmental MEA chamber, without harming cell cultures during experiments and without being damaged by the high humidity level. The devised system is of practical value in the development of in vitro platforms to study temporally extended neuronal network dynamics by means of MEAs.

  4. Technical study of the CO{sub 2} capture process with monoethanolamine for a thermoelectric plant; Estudio tecnico del proceso de captura de CO{sub 2} con monoetanolamina para una planta termoelectrica

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez Diaz, Abigail; Franco Nava, Jose Manuel; Peralta Martinez, Maria Vita; Gonzalez Santalo, Jose Miguel [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico); Franco Lopez, Rogelio; Carreon Silva, Ramon [Comision Federal de Electricidad (Mexico)

    2010-07-01

    Within the frame of the Special Program of Climatic Change (PECC) emitted by the Federal Government, the study of the process of CO{sub 2} capture is carried out post-combustion for application in generating power stations, as a possible alternative to reduce the CO{sub 2} emissions in Mexico. The simulation of the process of CO{sub 2} capture of gases generated by a thermoelectric power plant of 350 MW was carried out, that would use coal as fuel, in the processes simulator ASPEN HYSYS. For this process two columns are required: one of absorption, in which the gases and the solvent enter, that in this case were a solution of monoethanolamine (MEA) at 30%. MEA reacts with the CO{sub 2} contained in gases, retaining it, so that the remaining gases that are emitted to the atmosphere contain no longer MEA and the captured CO{sub 2} passes to the second column where these two components are separated, using thermal energy to regenerate the MEA releasing the CO{sub 2}. The released CO{sub 2} leaves though the upper part of the column and the MEA recovered that is reused in the absorption column, through the bottom. The CO{sub 2} concentration in gases of the combustion is of 14.54% by volume. The simulation was realized defining a capture efficiency of 90%, which threw a thermal power consumption to regenerate MEA of 4.75 GJt/ton CO{sub 2} that would be provided by the thermoelectric power station. Considering a capacity of 280 ton/h (by train) of the gas to be treated the height of the desertion and absorption columns was determined, as well as the MEA solution flow. [Spanish] Dentro del marco del Programa Especial de Cambio Climatico (PECC) emitido por el Gobierno Federal, se lleva a cabo el estudio del proceso de captura de CO{sub 2} poscombustion para aplicacion en centrales generadoras, como una posible alternativa para reducir las emisiones de CO{sub 2} en Mexico. Se llevo a cabo la simulacion del proceso de captura de CO{sub 2} de los gases generados por una

  5. Analysis of energy-based algorithms for RNA secondary structure prediction

    Directory of Open Access Journals (Sweden)

    Hajiaghayi Monir

    2012-02-01

    Full Text Available Abstract Background RNA molecules play critical roles in the cells of organisms, including roles in gene regulation, catalysis, and synthesis of proteins. Since RNA function depends in large part on its folded structures, much effort has been invested in developing accurate methods for prediction of RNA secondary structure from the base sequence. Minimum free energy (MFE predictions are widely used, based on nearest neighbor thermodynamic parameters of Mathews, Turner et al. or those of Andronescu et al. Some recently proposed alternatives that leverage partition function calculations find the structure with maximum expected accuracy (MEA or pseudo-expected accuracy (pseudo-MEA methods. Advances in prediction methods are typically benchmarked using sensitivity, positive predictive value and their harmonic mean, namely F-measure, on datasets of known reference structures. Since such benchmarks document progress in improving accuracy of computational prediction methods, it is important to understand how measures of accuracy vary as a function of the reference datasets and whether advances in algorithms or thermodynamic parameters yield statistically significant improvements. Our work advances such understanding for the MFE and (pseudo-MEA-based methods, with respect to the latest datasets and energy parameters. Results We present three main findings. First, using the bootstrap percentile method, we show that the average F-measure accuracy of the MFE and (pseudo-MEA-based algorithms, as measured on our largest datasets with over 2000 RNAs from diverse families, is a reliable estimate (within a 2% range with high confidence of the accuracy of a population of RNA molecules represented by this set. However, average accuracy on smaller classes of RNAs such as a class of 89 Group I introns used previously in benchmarking algorithm accuracy is not reliable enough to draw meaningful conclusions about the relative merits of the MFE and MEA-based algorithms

  6. CO{sub 2} adsorption in amine-grafted zeolite 13X

    Energy Technology Data Exchange (ETDEWEB)

    Bezerra, Diôgo P. [GPSA, Universidade Federal do Ceará (Brazil); Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Norte, Campus Ipanguaçu, Rio Grande do Norte (Brazil); Silva, Francisco W.M. da; Moura, Pedro A.S. de; Sousa, Allyson G.S.; Vieira, Rodrigo S. [GPSA, Universidade Federal do Ceará (Brazil); Rodriguez-Castellon, Enrique [Departamento de Química Inorgánica, Facultad de Ciencias, Universidad de Málaga, 29071 Málaga (Spain); Azevedo, Diana C.S., E-mail: diana@gpsa.ufc.br [GPSA, Universidade Federal do Ceará (Brazil)

    2014-09-30

    Highlights: • CO{sub 2} adsorption mechanism in amine-grafted zeolite 13X was investigated. • The loaded amine tends to fill zeolite micropores and most of it is unaccessible to react with CO{sub 2}. • Part of loaded MEA binds covalently to the zeolitic structure and will not detach from the surface even at low pressures. • Chemisorption is likely to lead to CO{sub 2} higher uptakes upon a rise in temperature for solids with the highest amine load. - Abstract: The adsorption of CO{sub 2} on Zeolite 13X functionalized with amino groups was studied. Adsorbent functionalization was carried out by grafting with different loads of monoethanolamine (MEA). The adsorbents were characterized by N{sub 2} adsorption/desorption isotherms at 77 K, x-ray diffraction, TGA, in situ FTIR, XPS and adsorption microcalorimetry. CO{sub 2} isotherms were studied in a gravimetric device up to 10 bar at 298 and 348 K. It was found that increasing loads of amine to the adsorbent tend to reduce micropore volume of the resulting adsorbents by pore blocking with MEA. There is experimental evidence that part of the loaded MEA is effectively covalently bonded to the zeolitic structure, whereas there is also physisorbed excess MEA which will eventually be desorbed by raising the temperature beyond MEA boiling point. Heats of adsorption at nearly zero coverage indicate that some of the adsorbed CO{sub 2} reacts with available amino groups, which agrees with the finding that the adsorption capacity increases with increasing temperature for the modified zeolite with the highest MEA load.

  7. Medial amygdala lesions selectively block aversive Pavlovian-instrumental transfer in rats.

    Directory of Open Access Journals (Sweden)

    Margaret Grace McCue

    2014-09-01

    Full Text Available Pavlovian conditioned stimuli (CSs play an important role in the reinforcement and motivation of instrumental active avoidance (AA. Conditioned threats can also invigorate ongoing AA responding (aversive Pavlovian-instrumental transfer or PIT. The neural circuits mediating AA are poorly understood, although lesion studies suggest that lateral, basal and central amygdala nuclei, as well as infralimbic prefrontal cortex, make key, and sometimes opposing, contributions. We recently completed an extensive analysis of brain c-Fos expression in good vs. poor avoiders following an AA test (Martinez et al 2013, Learning and Memory. This analysis identified medial amygdala (MeA as a potentially important region for Pavlovian motivation of instrumental actions. MeA is known to mediate defensive responding to innate threats as well as social behaviors, but its role in mediating aversive Pavlovian-instrumental interactions is unknown. We evaluated the effect of MeA lesions on Pavlovian conditioning, Sidman two-way AA conditioning (shuttling and aversive PIT in rats. Mild footshocks served as the unconditioned stimulus in all conditioning phases. MeA lesions had no effect on AA but blocked the expression of aversive PIT and 22 kHz ultrasonic vocalizations in the AA context. Interestingly, MeA lesions failed to affect Pavlovian freezing to discrete threats but reduced freezing to contextual threats when assessed outside of the AA chamber. These findings differentiate MeA from lateral and central amygdala, as lesions of these nuclei disrupt Pavlovian freezing and aversive PIT, but have opposite effects on AA performance. Taken together, these results suggest that MeA plays a selective role in the motivation of instrumental avoidance by general or uncertain Pavlovian threats.

  8. QSpike Tools: a Generic Framework for Parallel Batch Preprocessing of Extracellular Neuronal Signals Recorded by Substrate Microelectrode Arrays

    Directory of Open Access Journals (Sweden)

    Mufti eMahmud

    2014-03-01

    Full Text Available Micro-Electrode Arrays (MEAs have emerged as a mature technique to investigate brain (dysfunctions in vivo and in in vitro animal models. Often referred to as smart Petri dishes, MEAs has demonstrated a great potential particularly for medium-throughput studies in vitro, both in academic and pharmaceutical industrial contexts. Enabling rapid comparison of ionic/pharmacological/genetic manipulations with control conditions, MEAs are often employed to screen compounds by monitoring non-invasively the spontaneous and evoked neuronal electrical activity in longitudinal studies, with relatively inexpensive equipment. However, in order to acquire sufficient statistical significance, recordings last up to tens of minutes and generate large amount of raw data (e.g., 60 channels/MEA, 16 bits A/D conversion, 20kHz sampling rate: ~8GB/MEA,h uncompressed. Thus, when the experimental conditions to be tested are numerous, the availability of fast, standardized, and automated signal preprocessing becomes pivotal for any subsequent analysis and data archiving. To this aim, we developed an in-house cloud-computing system, named QSpike Tools, where CPU-intensive operations, required for preprocessing of each recorded channel (e.g., filtering, multi-unit activity detection, spike-sorting, etc., are decomposed and batch-queued to a multi-core architecture or to computer cluster. With the commercial availability of new and inexpensive high-density MEAs, we believe that disseminating QSpike Tools might facilitate its wide adoption and customization, and possibly inspire the creation of community-supported cloud-computing facilities for MEAs users.

  9. QSpike tools: a generic framework for parallel batch preprocessing of extracellular neuronal signals recorded by substrate microelectrode arrays.

    Science.gov (United States)

    Mahmud, Mufti; Pulizzi, Rocco; Vasilaki, Eleni; Giugliano, Michele

    2014-01-01

    Micro-Electrode Arrays (MEAs) have emerged as a mature technique to investigate brain (dys)functions in vivo and in in vitro animal models. Often referred to as "smart" Petri dishes, MEAs have demonstrated a great potential particularly for medium-throughput studies in vitro, both in academic and pharmaceutical industrial contexts. Enabling rapid comparison of ionic/pharmacological/genetic manipulations with control conditions, MEAs are employed to screen compounds by monitoring non-invasively the spontaneous and evoked neuronal electrical activity in longitudinal studies, with relatively inexpensive equipment. However, in order to acquire sufficient statistical significance, recordings last up to tens of minutes and generate large amount of raw data (e.g., 60 channels/MEA, 16 bits A/D conversion, 20 kHz sampling rate: approximately 8 GB/MEA,h uncompressed). Thus, when the experimental conditions to be tested are numerous, the availability of fast, standardized, and automated signal preprocessing becomes pivotal for any subsequent analysis and data archiving. To this aim, we developed an in-house cloud-computing system, named QSpike Tools, where CPU-intensive operations, required for preprocessing of each recorded channel (e.g., filtering, multi-unit activity detection, spike-sorting, etc.), are decomposed and batch-queued to a multi-core architecture or to a computers cluster. With the commercial availability of new and inexpensive high-density MEAs, we believe that disseminating QSpike Tools might facilitate its wide adoption and customization, and inspire the creation of community-supported cloud-computing facilities for MEAs users.

  10. Fabrication and characterisation of high performance polypyrrole modified microarray sensor for ascorbic acid determination

    Energy Technology Data Exchange (ETDEWEB)

    Samseya, J. [Alagappa University, Karaikudi, Tamil Nadu (India); Srinivasan, R., E-mail: sivarunjan@gmail.com [Central Electro Chemical Research Insititute, Karaikudi, Tamil Nadu (India); Chang, Yu-Tsern; Tsao, Cheng-Wen [Department of Cosmetic Applications, Taoyuan Innovation Institute of Technology, Taiwan (China); Vasantha, V.S. [Madurai Kamaraj University, Madurai, Tamil Nadu (India)

    2013-09-02

    Graphical abstract: -- Highlights: •Gold microelectrode array (Au/MEA) with electrode of 12 μm diameter was fabricated by photolithography technique. •Subsequently, polypyrrole (Ppy) modified gold microarrays sensor (Ppy/Au/MEA) was prepared. •Ppy/Au/MEA used for ascorbic acid determination in the presence of different neurotransmitters. •The micro array exhibited wide linear range, very high sensitivity and very low LOD than the earlier reports. •It was used successfully to test ascorbic acid in different types real samples. -- Abstract: In this study, gold microelectrode array (Au/MEA) with electrode of 12 μm diameter was fabricated by photolithography technique. Subsequently, polypyrrole (Ppy) modified gold microarrays sensor (Ppy/Au/MEA) was prepared by cyclic voltammetry technique. The deposition potential range and number of cycles were optimised in order to get optimum thickness of Ppy film. Scanning Electron Microscope and Atomic Force Microscope investigations reveal that Ppy coating formed at 3 cycles is porous with thickness of 1.5 μm which exhibiting high catalytic current for ascorbic acid (AA) in square wave technique (SWV). In contrast to earlier sensors designs, these Ppy/Au/MEA sensors exhibits lower detection limit (LOD) of 10 nm towards AA at physiological conditions. It also exhibits enhanced sensitivity (2.5 mA cm{sup −2} mM{sup −1}) and long range of linear detection limit from 10 nm to 2.8 mM. In the same way, polypyrrole modified macro Au (Ppy/Au/MA) biosensor was also fabricated and its electro catalytic property towards AA was compared with that of Ppy/Au/MEA. The Ppy/Au/MA exhibits sensitivity of only 0.27 mA cm{sup −2} mM{sup −1}, LOD of 5 μM and linear range of 10 μM to 2.2 mM. Hence, our investigations indicate that the Ppy/Au/MEA could serve as highly sensitive sensor for AA than any of the earlier designs. So, the Ppy/Au/MEA electrode was utilised for determination AA in a wide variety of real samples.

  11. Assessment of Platelet Function in Traumatic Brain Injury—A Retrospective Observational Study in the Neuro-Critical Care Setting

    Directory of Open Access Journals (Sweden)

    Caroline Lindblad

    2018-01-01

    Full Text Available BackgroundDespite seemingly functional coagulation, hemorrhagic lesion progression is a common and devastating condition following traumatic brain injury (TBI, stressing the need for new diagnostic techniques. Multiple electrode aggregometry (MEA measures platelet function and could aid in coagulopathy assessment following TBI. The aims of this study were to evaluate MEA temporal dynamics, influence of concomitant therapy, and its capabilities to predict lesion progression and clinical outcome in a TBI cohort.Material and methodsAdult TBI patients in a neurointensive care unit that underwent MEA sampling were retrospectively included. MEA was sampled if the patient was treated with antiplatelet therapy, bled heavily during surgery, or had abnormal baseline coagulation values. We assessed platelet activation pathways involving the arachidonic acid receptor (ASPI, P2Y12 receptor, and thrombin receptor (TRAP. ASPI was the primary focus of analysis. If several samples were obtained, they were included. Retrospective data were extracted from hospital charts. Outcome variables were radiologic hemorrhagic progression and Glasgow Outcome Scale assessed prospectively at 12 months posttrauma. MEA levels were compared between patients on antiplatelet therapy. Linear mixed effect models and uni-/multivariable regression models were used to study longitudinal dynamics, hemorrhagic progression and outcome, respectively.ResultsIn total, 178 patients were included (48% unfavorable outcome. ASPI levels increased from initially low values in a time-dependent fashion (p < 0.001. Patients on cyclooxygenase inhibitors demonstrated low ASPI levels (p < 0.001, while platelet transfusion increased them (p < 0.001. The first ASPI (p = 0.039 and TRAP (p = 0.009 were significant predictors of outcome, but not lesion progression, in univariate analyses. In multivariable analysis, MEA values were not independently correlated with outcome

  12. Fabrication and characterisation of high performance polypyrrole modified microarray sensor for ascorbic acid determination

    International Nuclear Information System (INIS)

    Samseya, J.; Srinivasan, R.; Chang, Yu-Tsern; Tsao, Cheng-Wen; Vasantha, V.S.

    2013-01-01

    Graphical abstract: -- Highlights: •Gold microelectrode array (Au/MEA) with electrode of 12 μm diameter was fabricated by photolithography technique. •Subsequently, polypyrrole (Ppy) modified gold microarrays sensor (Ppy/Au/MEA) was prepared. •Ppy/Au/MEA used for ascorbic acid determination in the presence of different neurotransmitters. •The micro array exhibited wide linear range, very high sensitivity and very low LOD than the earlier reports. •It was used successfully to test ascorbic acid in different types real samples. -- Abstract: In this study, gold microelectrode array (Au/MEA) with electrode of 12 μm diameter was fabricated by photolithography technique. Subsequently, polypyrrole (Ppy) modified gold microarrays sensor (Ppy/Au/MEA) was prepared by cyclic voltammetry technique. The deposition potential range and number of cycles were optimised in order to get optimum thickness of Ppy film. Scanning Electron Microscope and Atomic Force Microscope investigations reveal that Ppy coating formed at 3 cycles is porous with thickness of 1.5 μm which exhibiting high catalytic current for ascorbic acid (AA) in square wave technique (SWV). In contrast to earlier sensors designs, these Ppy/Au/MEA sensors exhibits lower detection limit (LOD) of 10 nm towards AA at physiological conditions. It also exhibits enhanced sensitivity (2.5 mA cm −2 mM −1 ) and long range of linear detection limit from 10 nm to 2.8 mM. In the same way, polypyrrole modified macro Au (Ppy/Au/MA) biosensor was also fabricated and its electro catalytic property towards AA was compared with that of Ppy/Au/MEA. The Ppy/Au/MA exhibits sensitivity of only 0.27 mA cm −2 mM −1 , LOD of 5 μM and linear range of 10 μM to 2.2 mM. Hence, our investigations indicate that the Ppy/Au/MEA could serve as highly sensitive sensor for AA than any of the earlier designs. So, the Ppy/Au/MEA electrode was utilised for determination AA in a wide variety of real samples

  13. Optimization of synthesis of the nickel-cobalt oxide based anode electrocatalyst and of the related membrane-electrode assembly for alkaline water electrolysis

    Science.gov (United States)

    Chanda, Debabrata; Hnát, Jaromir; Bystron, Tomas; Paidar, Martin; Bouzek, Karel

    2017-04-01

    In this work, the Ni-Co spinel oxides are synthesized via different methods and using different calcination temperatures. Properties of the prepared materials are compared. The best route is selected and used to prepare a Ni1+xCo2-xO4 (-1 ≤ x ≤ 1) series of materials in order to investigate their catalytic activity towards the oxygen evolution reaction (OER). The results show that hydroxide preparation yields NiCo2O4 oxide with the highest activity. 325 °C is identified as the optimum calcination temperature. Subsequently, the catalysts are tested in an electrolysis cell. To prepare an anode catalyst layer based on NiCo2O4 catalyst on top of a nickel foam substrate for membrane electrode assembly (MEA) construction, following polymer binders are used: anion-selective quaternized polyphenylene oxide (qPPO), inert polytetrafluoroethylene (PTFE®), and cation-selective Nafion®. qPPO ionomer containing MEA exhibited highest OER activity. The current density obtained using a MEA containing qPPO binder attains a value of 135 mA cm-2 at a cell voltage of 1.85 V. After 7 h chronopotentiometric experiment at a constant current density of 225 mA cm-2, the MEA employing PTFE® binder shows higher stability than the other binders in alkaline water electrolysis at 50 °C. Under similar conditions, stability of the PTFE®-binding MEA is examined for 135 h.

  14. Effect of Ethanolamines on Corrosion Inhibition of Ductile Cast Iron in Nitrite Containing Solutions

    International Nuclear Information System (INIS)

    Kim, K. T.; Kim, Y. S.; Chang, H. Y.; Lim, B. T.; Park, H. B.

    2016-01-01

    In this work, synergistic corrosion inhibition effect of nitrite and 3 kinds of ethanolamines on ductile cast iron using chemical and electrochemical methods was evaluated. This work attempts to clarify the synergistic effect of nitrite and ethanolamines. The effects of single addition of TEA, DEA, and MEA, and mixed addition of nitrite plus TEA, DEA or MEA on the corrosion inhibition of ductile cast iron in a tap water were evaluated. A huge amount of single addition of ethanolamine was needed. However, the synergistic effect by mixed addition was observed regardless of the combination of nitrite and triethanolamines, but their effects increased in a series of MEA + nitrite > DEA + nitrite > TEA + nitrite. This tendency of synergistic effect was attributed to the film properties and polar effect; TEA addition couldn't form the film showing high film resistance and semiconductive properties, but DEA or MEA could build the film having relatively high film resistance and n-type semiconductive properties. Moreover, it can be explained that this behaviour was closely related to electron attractive group within the ethanolamines, and thus corrosion inhibition power depends upon the number of the electron attractive group of MEA, DEA, and TEA.

  15. Nanostructured gold microelectrodes for extracellular recording

    Energy Technology Data Exchange (ETDEWEB)

    Brueggemann, Dorothea; Wolfrum, Bernhard; Maybeck, Vanessa; Offenhaeusser, Andreas [CNI Center of Nanoelectronic Systems for Information Technology and Institute of Bio- and Nanosystems 2, Forschungszentrum Juelich (Germany)

    2010-07-01

    Electrophysiological activity of electrogenic cells is currently recorded with planar bioelectronic interfaces such as microelectrode arrays (MEAs). In this work, a novel concept of biocompatible nanostructured gold MEAs for extracellular signal recording is presented. MEAs were fabricated using clean room technologies, e.g. photolithography and metallization. Subsequently, they were modified with gold nanopillars of approximately 300 to 400 nm in height and 60 nm width. The nanostructuring process was carried out with a template-assisted approach using nanoporous aluminium oxide. Impedance spectroscopy of the resulting nanostructures showed higher capacitances compared to planar gold. This confirmed the expected increase of the surface area via nanostructuring. We used the nanostructured microelectrodes to record extracellular potentials from heart muscle cells (HL1), which were plated onto the chips. Good coupling between the HL1 cells and the nanostructured electrodes was observed. The resulting signal-to-noise ratio of nanopillar-MEAs was increased by a factor of 2 compared to planar MEAs. In future applications this nanopillar concept can be adopted for distinct interface materials and coupling to cellular and molecular sensing components.

  16. Microscopic characterizations of membrane electrode assemblies prepared under different hot-pressing conditions

    International Nuclear Information System (INIS)

    Liang, Z.X.; Zhao, T.S.; Xu, C.; Xu, J.B.

    2007-01-01

    The durability of the membrane electrode assembly (MEA) for direct methanol fuel cells (DMFCs) is one of the most critical issues to be addressed before widespread commercialization of the DMFC technology. In this work, we investigated the effect of the hot-pressing duration on the performance and durability of the MEA prepared by hot-pressing technique. It was found that the 60-min hot pressing at 135 deg. C under the pressure of 4.0 MPa yielded a significantly improved MEA durability than did the 3-min hot pressing (a typical duration in practice) under the same condition, but no substantial difference was found in the cell performance of the MEAs prepared with the two different hot-pressing durations. The reason why the hot-pressing duration had no significant effect on cell performance is explained based on X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared spectroscopy (FT-IR) characterizations of the changes in the physiochemical properties of MEAs and their constituent components, including the anode, cathode and Nafion membrane, before and after hot pressing with different durations

  17. 2-methylanthraquinone as a marker of occupational exposure to teak wood dust in boatyards.

    Science.gov (United States)

    Gori, Giampaolo; Carrieri, Mariella; Scapellato, Maria Luisa; Parvoli, Giorgio; Ferrara, Daniela; Rella, Rocco; Sturaro, Alberto; Bartolucci, Giovanni Battista

    2009-01-01

    A new gas chromatographic/mass spectrometric (GC/MS) method was developed to detect 2-methylanthraquinone (2-MeA) in wood dust. 2-MeA is present in teak wood (a suspected human carcinogen) but not in oak, beech, mahogany, birch, ash or pine. The method involved collection of workplace dust on filters and extraction of 2-MeA with methanol and GC/MS analysis. The method was tested on teak wood dust samples (n = 43) collected on polyvinylchloride membrane filters during various work operations in four small factories making furniture and fittings for leisure craft and boatyards (air teak wood dust concentration: range 0.32-14.32 mg m(-3)). A high correlation coefficient for the content of 2-MeA versus teak dust was obtained (logarithmic correlation: y = 1.5308x + 0.0998, r = 0.9215). Determination of airborne 2-MeA is a useful technique to confirm occupational exposure to teak wood dust.

  18. Effect of Ethanolamines on Corrosion Inhibition of Ductile Cast Iron in Nitrite Containing Solutions

    Energy Technology Data Exchange (ETDEWEB)

    Kim, K. T.; Kim, Y. S. [Andong National University, Andong (Korea, Republic of); Chang, H. Y.; Lim, B. T.; Park, H. B. [KEPCO Engineering and Construction Company, Gimcheon (Korea, Republic of)

    2016-08-15

    In this work, synergistic corrosion inhibition effect of nitrite and 3 kinds of ethanolamines on ductile cast iron using chemical and electrochemical methods was evaluated. This work attempts to clarify the synergistic effect of nitrite and ethanolamines. The effects of single addition of TEA, DEA, and MEA, and mixed addition of nitrite plus TEA, DEA or MEA on the corrosion inhibition of ductile cast iron in a tap water were evaluated. A huge amount of single addition of ethanolamine was needed. However, the synergistic effect by mixed addition was observed regardless of the combination of nitrite and triethanolamines, but their effects increased in a series of MEA + nitrite > DEA + nitrite > TEA + nitrite. This tendency of synergistic effect was attributed to the film properties and polar effect; TEA addition couldn't form the film showing high film resistance and semiconductive properties, but DEA or MEA could build the film having relatively high film resistance and n-type semiconductive properties. Moreover, it can be explained that this behaviour was closely related to electron attractive group within the ethanolamines, and thus corrosion inhibition power depends upon the number of the electron attractive group of MEA, DEA, and TEA.

  19. The 21st century skills with model eliciting activities on linear program

    Science.gov (United States)

    Handajani, Septriana; Pratiwi, Hasih; Mardiyana

    2018-04-01

    Human resources in the 21st century are required to master various forms of skills, including critical thinking skills and problem solving. The teaching of the 21st century is a teaching that integrates literacy skills, knowledge, skills, attitudes, and mastery of ICT. This study aims to determine whether there are differences in the effect of applying Model Elliciting Activities (MEAs) that integrates 21st century skills, namely 4C and conventional learning to learning outcomes. This research was conducted at Vocational High School in the odd semester of 2017 and uses the experimental method. The experimental class is treated MEAs that integrates 4C skills and the control class is given conventional learning. Methods of data collection in this study using the method of documentation and test methods. The data analysis uses Z-test. Data obtained from experiment class and control class. The result of this study showed there are differences in the effect of applying MEAs that integrates 4C skills and conventional learning to learning outcomes. Classes with MEAs that integrates 4C skills give better learning outcomes than the ones in conventional learning classes. This happens because MEAs that integrates 4C skills can improved creativity skills, communication skills, collaboration skills, and problem-solving skills.

  20. A high-throughput electrochemical impedance spectroscopy evaluation of bioresponsibility of the titanium microelectrode array integrated with hydroxyapatite and silver

    International Nuclear Information System (INIS)

    Zhang Fan; Lin Longxiang; Wang Guowei; Hu Ren; Lin Changjian; Chen Yong

    2012-01-01

    Highlights: ► The EIS of living MG63 cells on the Ti MEA chip with Ag, HA, and Ag–HA was monitored. ► The R cell can be related to the bioresponsibility of the coatings. ► The bioactivity order was evaluated as follows: Ti–Ag–HA > Ti–HA ≈ Ti–Ag > Ti. - Abstract: This paper reports a transparent Ti microelectrode array (MEA) system for a high-throughput evaluation of bioresponsibility using electrochemical impedance spectroscopy (EIS). The MEA chip integrated with hydroxyapatite (HA) and Ag coatings was selectively prepared by electrochemical deposition based on a novel procedure of multichannel current control. The EIS measurement of living MG63 osteosarcoma cells in the integrated MEA chip was conducted, and the result was analyzed using an equivalent circuit corresponding to a titanium oxide film, protein adsorption layer, cell adhesion layer, and medium. It is shown that the bioresponsibility of Ti–Ag–HA on the MEA chip can be improved, compared with the Ti, Ti–HA, and Ti–Ag coatings. The system was further used for real-time EIS monitoring during continuous cell culture for a long period (12 days). The effect of the long-term cell proliferation on the EIS behavior was discussed. This integrated system is valuable to significantly simplify the operation procedures and quickly evaluate the bioresponsibility of biomaterials.

  1. Studies on mould growth and biomass production using waste banana peel.

    Science.gov (United States)

    Essien, J P; Akpan, E J; Essien, E P

    2005-09-01

    Hyphomycetous (Aspergillus fumigatus) and Phycomycetous (Mucor hiemalis) moulds were cultivated in vitro at room temperature (28 + 20 degrees C) to examined their growth and biomass production on waste banana peel agar (BPA) and broth (BPB) using commercial malt extract agar (MEA) and broth (MEB) as control. The moulds grew comparatively well on banana peel substrates. No significant difference (p > 0.05) in radial growth rates was observed between moulds cultivated on PBA and MEA, although growth rates on MEA were slightly better. Slight variations in sizes of asexual spores and reproductive hyphae were also observed between moulds grown on MEA and BPA. Smaller conidia and sporangiospores, and shorter aerial hyphae (conidiophores and sporangiophores) were noticed in moulds grown on BPA than on MEA. The biomass weight of the test moulds obtained after one month of incubation with BPB were only about 1.8 mg and 1.4 mg less than values recorded for A. fumigatus and M. hiemalis respectively, grown on MEB. The impressive performance of the moulds on banana peel substrate may be attributed to the rich nutrient (particularly the crude protein 7.8% and crude fat 11.6% contents) composition of banana peels. The value of this agricultural waste can therefore be increased by its use not only in the manufacture of mycological medium but also in the production of valuable microfungal biomass which is rich in protein and fatty acids.

  2. Silicon Wafer-Based Platinum Microelectrode Array Biosensor for Near Real-Time Measurement of Glutamate in Vivo

    Directory of Open Access Journals (Sweden)

    Nigel T. Maidment

    2008-08-01

    Full Text Available Using Micro-Electro-Mechanical-Systems (MEMS technologies, we have developed silicon wafer-based platinum microelectrode arrays (MEAs modified with glutamate oxidase (GluOx for electroenzymatic detection of glutamate in vivo. These MEAs were designed to have optimal spatial resolution for in vivo recordings. Selective detection of glutamate in the presence of the electroactive interferents, dopamine and ascorbic acid, was attained by deposition of polypyrrole and Nafion. The sensors responded to glutamate with a limit of detection under 1μM and a sub-1-second response time in solution. In addition to extensive in vitro characterization, the utility of these MEA glutamate biosensors was also established in vivo. In the anesthetized rat, these MEA glutamate biosensors were used for detection of cortically-evoked glutamate release in the ventral striatum. The MEA biosensors also were applied to the detection of stress-induced glutamate release in the dorsal striatum of the freely-moving rat.

  3. Sobol's sensitivity analysis for a fuel cell stack assembly model with the aid of structure-selection techniques

    Science.gov (United States)

    Zhang, Wei; Cho, Chongdu; Piao, Changhao; Choi, Hojoon

    2016-01-01

    This paper presents a novel method for identifying the main parameters affecting the stress distribution of the components used in assembly modeling of proton exchange membrane fuel cell (PEMFC) stack. This method is a combination of an approximation model and Sobol's method, which allows a fast global sensitivity analysis for a set of uncertain parameters using only a limited number of calculations. Seven major parameters, i.e., Young's modulus of the end plate and the membrane electrode assembly (MEA), the contact stiffness between the MEA and bipolar plate (BPP), the X and Y positions of the bolts, the pressure of each bolt, and the thickness of the end plate, are investigated regarding their effect on four metrics, i.e., the maximum stresses of the MEA, BPP, and end plate, and the stress distribution percentage of the MEA. The analysis reveals the individual effects of each parameter and its interactions with the other parameters. The results show that the X position of a bolt has a major influence on the maximum stresses of the BPP and end plate, whereas the thickness of the end plate has the strongest effect on both the maximum stress and the stress distribution percentage of the MEA.

  4. Analysis of Investment IT Planning on Logistic Company Using COBIT 5

    Science.gov (United States)

    Fachri Pane, Syafrial; Maulana Awangga, Rolly; Nuraini, Rd.; Fathonah, Siti

    2018-04-01

    IT Investment planning to review goals business strategy development needs to support IT governance. Planning its investments will be assessed with a framework is issued by ISACA that COBIT 5 focus on domain EDM, APO, BAI, and MEA. Mapping from framework COBIT 5 with Val IT lead nine domain consisting of EDM01, EDM02, APO01, APO02, APO05, APO06, APO07, BAI01, and MEA01. Article search google using RACI diagram generating mapping organisation telecoms and authority structures for the review identify respondents from any domain. Under selected area be used to review counting process capability level, and for a discussion of development, priorities make recommendations shall perform in accordance process needs PT.XYZ logistics company. The translating process capability level determined by the company prior currently at on level 4. The capability level domain process in the EDM is level 4, while at domain APO, BAI, and MEA are on level 3 and gap on APO, BAI, and MEA. The company recommendation domain subscription APO, BAI, and MEA to increase the capabilities of the rate review process to achieve the targets that have can determine the company.

  5. Physical Absorption of Green House Gases in Amines: The Influence of Functionality, Structure, and Cross-Interactions.

    Science.gov (United States)

    Orozco, Gustavo A; Lachet, Véronique; Mackie, Allan D

    2016-12-29

    Monte Carlo simulations were performed in the isothermal-isobaric ensemble (NPT) to calculate the Henry constants of methane (CH 4 ), nitrous oxide (N 2 O), and carbon dioxide (CO 2 ) in pure H 2 O, amines, and alkanolamines using the classical Lorentz-Berthelot combining rules (L-B). The Henry constants of N 2 O and CO 2 in water are highly overestimated and motivated us to propose a new set of unlike interactions. Contrarily, the Henry constant of N 2 O in MEA is underestimated by around 40%, and again, a new reoptimized cross unlike parameter is able to reproduce the constant to within 10%. An analysis is given of the relationship between the physical absorption of these gases and the chemical structure or functionality of 12 molecules including amines and alkanolamines using the anisotropic united atom intermolecular potential (AUA4). Finally, the solubility of N 2 O in an aqueous solution of monoethanolamine (MEA) at 30% (wt) was also studied. A Henry constant within 7% of the experimental value was found by using the reoptimized parameters along with L-B to account for the MEA + H 2 O unlike interactions. This very good agreement without additional adjustments for the MEA + H 2 O system may be attributed to the good excess properties predictions found in previous works for the binary mixture (MEA + H 2 O). However, further work, including additional alkanolamines in aqueous solutions at several concentrations, is required to verify this particular point.

  6. Characterization of Early Cortical Neural Network ...

    Science.gov (United States)

    We examined the development of neural network activity using microelectrode array (MEA) recordings made in multi-well MEA plates (mwMEAs) over the first 12 days in vitro (DIV). In primary cortical cultures made from postnatal rats, action potential spiking activity was essentially absent on DIV 2 and developed rapidly between DIV 5 and 12. Spiking activity was primarily sporadic and unorganized at early DIV, and became progressively more organized with time in culture, with bursting parameters, synchrony and network bursting increasing between DIV 5 and 12. We selected 12 features to describe network activity and principal components analysis using these features demonstrated a general segregation of data by age at both the well and plate levels. Using a combination of random forest classifiers and Support Vector Machines, we demonstrated that 4 features (CV of within burst ISI, CV of IBI, network spike rate and burst rate) were sufficient to predict the age (either DIV 5, 7, 9 or 12) of each well recording with >65% accuracy. When restricting the classification problem to a binary decision, we found that classification improved dramatically, e.g. 95% accuracy for discriminating DIV 5 vs DIV 12 wells. Further, we present a novel resampling approach to determine the number of wells that might be needed for conducting comparisons of different treatments using mwMEA plates. Overall, these results demonstrate that network development on mwMEA plates is similar to

  7. The effects to the structure and electrochemical behavior of zinc phosphate conversion coatings with ethanolamine on magnesium alloy AZ91D

    International Nuclear Information System (INIS)

    Li Qing; Xu Shuqiang; Hu Junying; Zhang Shiyan; Zhong Xiankang; Yang Xiaokui

    2010-01-01

    This paper discussed a zinc phosphate conversion coating formed on magnesium alloy AZ91D from the phosphating bath with varying amounts of ethanolamine (MEA). The effects of MEA on the form, structure, phase composition and electrochemical behavior of the phosphate coatings were examined using an scanning electron microscopy (SEM), X-ray diffraction (XRD) potentiodynamic polarization curves and electrochemical impedance spectroscopy (EIS) measurements. Interpretations of the electrical elements of the equivalent circuit were obtained from the SEM structure of the coatings, assumed to be formed of two layers: an outer porous crystal layer and an inner flat amorphous layer. The result showed that adding MEA refined the microstructure of the crystal layer and that the phosphate coating, derived at the optimal content of 1.2 g/L, with the most uniform and compact outer crystal layer provided the best corrosion protection.

  8. A simulation study on the abatement of CO2 emissions by de-absorption with monoethanolamine.

    Science.gov (United States)

    Greer, T; Bedelbayev, A; Igreja, J M; Gomes, J F; Lie, B

    2010-01-01

    Because of the adverse effect of CO2 from fossil fuel combustion on the earth's ecosystems, the most cost-effective method for CO2 capture is an important area of research. The predominant process for CO2 capture currently employed by industry is chemical absorption in amine solutions. A dynamic model for the de-absorption process was developed with monoethanolamine (MEA) solution. Henry's law was used for modelling the vapour phase equilibrium of the CO2, and fugacity ratios calculated by the Peng-Robinson equation of state (EOS) were used for H2O, MEA, N2 and O2. Chemical reactions between CO2 and MEA were included in the model along with the enhancement factor for chemical absorption. Liquid and vapour energy balances were developed to calculate the liquid and vapour temperature, respectively.

  9. ACACIA Project - Development of a Post-Combustion CO2 Capture Process. Case of the DMXTM Process

    International Nuclear Information System (INIS)

    Gomez, A.; Briot, P.; Raynal, L.; Broutin, P.; Gimenez, M.; Soazic, M.; Cessat, P.; Saysset, S.

    2014-01-01

    The objective of the ACACIA project was to develop processes for post-combustion CO 2 capture at a lower cost and with a higher energetic efficiency than first generation processes using amines such as Monoethanolamine (MEA) which are now considered for the first Carbon Capture and Storage (CCS) demonstrators. The partners involved in this project were: Rhodia (Solvay since then), Arkema, Lafarge, GDF SUEZ, Veolia Environnement, IFP Energies nouvelles, IRCE Lyon, LMOPS, LTIM, LSA Armines. To validate the relevance of the breakthrough processes studied in this project, techno-economic evaluations were carried out with comparison to the reference process using a 30 wt% MEA solvent. These evaluation studies involved all the industrial partners of the project, each partner bringing specific cases of CO 2 capture on their industrial facilities. From these studies, only the process using de-mixing solvent, DMX TM , developed by IFPEN appears as an alternative solution to the MEA process. (authors)

  10. The Role of Adat Justice and Its Adat Institutons in Preventing Transnational Crimes in Aceh Province, Indonesia

    Directory of Open Access Journals (Sweden)

    Sri Walny Rahayu

    2017-12-01

    Lebih dari satu dekade setelah berlakunya Undang-Undang No. 11 Tahun 2006 tentang Pemerintahan Aceh, kemampuan adaptif peradilan adat dan lembaga adat Aceh terus bertahan karena memiliki dasar legalitas penormaan yang kuat diatur dalam undang-undang dan peraturan di Indonesia. Di sisi lain jika dikaji, konsekuensi pelaksanaan Masyarakat Ekonomi Asean (MEA efektif berlaku 31 Desember 2015 di Indonesia berpotensi menimbulkan ancaman seperti munculnya berbagai bentuk kejahatan transnasional yang melintasi perbatasan suatu negara, dilakukan oleh pelaku dari dua atau lebih negara dengan modus operandi modern. Berlakunya MEA bagi Aceh merupakan tantangan memanfaatkan peluang peradilan adat dan lembaga adat mengantisipasi kejahatan tersebut. Berdasarkan data dari ASEAN Rencana Aksi untuk memerangi kejahatan transnasional terdapat delapan bentuk kejahatan yaitu, perdagangan gelap narkoba, perdagangan manusia, laut-pembajakan, penyelundupan senjata, pencucian uang, terorisme, kejahatan ekonomi internasional dan cyber crimes. Tulisan ini bertujuan menjelaskan kemampuan adaptif peradilan adat, lembaga adat Aceh, dan model intervensi peradilan adat di Aceh menghadapi kejahatan transnasional era MEA.

  11. Development and fabrication of membrane electrode assembly for PEM fuel cell

    International Nuclear Information System (INIS)

    Anjum, M.A.R.; Arshad, M.; Hussain, S.; Saeed, M.M.

    2011-01-01

    The 10 cm x 10 cm active area membrane electrode assembly (MEA) has been fabricated by adopting two routes, i.e., catalyst-coated membrane (CCM) and catalyst-coated support (CCS). In CCM method, the catalyst is directly applied on the Nafion membrane while in CCS method, catalyst is applied on support (GDL). The catalyst layer was prepared by nano-sized platinum on carbon particle, the ionomer material of the membrane and a solvent that allows the catalyst to behave like ink. The catalyst slurry was applied on the membrane, hot-pressed the sandwich of GDL and catalyst-coated Nafion membrane to form a single unit which behaves as electrodes. The primary tests regarding the efficiency of indigenously-fabricated MEAs have been carried out successfully. The performance of MEA with respect to continuous operation for long hours from the standpoint of proper functioning was also checked. A maximum power of 13 watt was obtained. (author)

  12. Absorption of CO2 in Biogas with Amine Solution for Biomethane Enrichment

    Directory of Open Access Journals (Sweden)

    Wassana Kamopas

    2016-05-01

    Full Text Available Biogas upgrading with carbon dioxide absorption in a column of monoethanolamine (MEA solution was carried out. The effects of controlled parameters on the CO2 absorption such as gas flow rate, solution concentration, height to diameter ratio of the column were considered. High CH4 concentration could be achieved at low gas flow rate and high MEA concentration. The CH4 concentration could be up from 70-75% to 92-95% by volume for 0.2 M MEA. A set of breakthrough curves was obtained to determine the absorption characteristics, such as the absorption constant (k, the absorption time when the CO2 concentration at the outlet was 50% of the concentration at the inlet (t, and the absorption period (t* when the CH4 concentration was over 90%. An empirical equation of the methane enrichment with the related parameters was developed.

  13. Systematic discrepancies in Monte Carlo predictions of k-ratios emitted from thin films on substrates

    International Nuclear Information System (INIS)

    Statham, P; Llovet, X; Duncumb, P

    2012-01-01

    We have assessed the reliability of different Monte Carlo simulation programmes using the two available Bastin-Heijligers databases of thin-film measurements by EPMA. The MC simulation programmes tested include Curgenven-Duncumb MSMC, NISTMonte, Casino and PENELOPE. Plots of the ratio of calculated to measured k-ratios ('k calc /k meas ') against various parameters reveal error trends that are not apparent in simple error histograms. The results indicate that the MC programmes perform quite differently on the same dataset. However, they appear to show a similar pronounced trend with a 'hockey stick' shape in the 'k calc /k meas versus k meas ' plots. The most sophisticated programme PENELOPE gives the closest correspondence with experiment but still shows a tendency to underestimate experimental k-ratios by 10 % for films that are thin compared to the electron range. We have investigated potential causes for this systematic behaviour and extended the study to data not collected by Bastin and Heijligers.

  14. Transport properties of binary liquid mixtures - candidate solvents for optimized flue gas cleaning processes

    Directory of Open Access Journals (Sweden)

    Stanimirović Andrej M.

    2016-01-01

    Full Text Available Thermal conductivities and viscosities of three pure chemicals, monoethanol amine (MEA, tetraethylene glycol dimethyl ether (TEGDME and polyethylene glycol 200 (PEG 200 and two binary mixtures (MEA + + TEGDME and MEA + PEG 200 were measured at six temperatures: 298.15, 303.15, 308.15, 313.15, 318.15 and 323.15 K and atmospheric pressure. Measurement of thermal conductivities was based on a transient hot wire measurement setup, while viscosities were measured with a digital Stabinger SVM 3000/G2 viscometer. From these data, deviations in thermal conductivity and viscosity were calculated and fitted to the Redlich-Kister equation. Thermal conductivities of mixtures were correlated using Filippov, Jamieson, Baroncini and Rowley models, while viscosity data were correlated with the Eyring-UNIQUAC, Eyring-NRTL and McAlistermodels. [Projekat Ministarstva nauke Republike Srbije, br. 172063

  15. Microelectrode array fabrication for electrochemical detection with carbon nanotubes

    Science.gov (United States)

    Clark, James

    Understanding how the brain works remains one of the key challenges for scientists. To further this understanding a wide variety of technologies and research methods have been developed. One such technology is conductive electrodes, used to measure the electrical signals elicited from neuronal cells and tissues. These electrodes can be fabricated as a singular electrode or as a multi-electrode array (MEA). This permits bio-electrical measurements from one particular area or simultaneous measurements from multiple areas, respectively. Studying electrical and chemical signals of individual cells in situ requires the use of electrodes with ≤20 µm diameter. However, electrodes of this size generally produce high impedance, perturbing recording of the small signals generated from individual cells. Nanomaterials, such as carbon nanotubes (CNTs), can be deposited to increase the real surface area of these electrodes, producing higher sensitivity measurements. This thesis investigates the potential for using photo-thermal chemical vapour deposition grown CNTs as the electrode material for a de novo fabricated MEA. This device aimed to measure electrochemical signals in the form of dopamine, an important mammalian neurotransmitter, as well as conventional bio-electrical signals that the device is designed for. Realising this aim began with improving CNT aqueous wetting behaviour via oxygen plasma functionalisation. This procedure demonstrated grafting of oxygen functional groups to the CNT structure, and dramatic improvements in aqueous wetting behaviour, with CNTs attached to the device. Subsequently, oxygen plasma functionalised CNT-based MEAs were fabricated and tested, allowing comparisons with a non-functionalised CNT MEA and a state-of-the-art commercial MEA. The functionalised CNT MEA demonstrated an order of magnitude improvement compared to commercial MEAs (2.75 kΩ vs. 25.6 kΩ), at the biologically relevant frequency of 1 kHz. This was followed by measurement

  16. Analysis of mathematical literacy ability based on goal orientation in model eliciting activities learning with murder strategy

    Science.gov (United States)

    Wijayanti, R.; Waluya, S. B.; Masrukan

    2018-03-01

    The purpose of this research are (1) to analyze the learning quality of MEAs with MURDER strategy, (2) to analyze students’ mathematical literacy ability based on goal orientation in MEAs learning with MURDER strategy. This research is a mixed method research of concurrent embedded type where qualitative method as the primary method. The data were obtained using the methods of scale, observation, test and interviews. The results showed that (1) MEAs Learning with MURDER strategy on students' mathematical literacy ability is qualified, (2) Students who have mastery goal characteristics are able to master the seven components of mathematical literacy process although there are still two components that the solution is less than the maximum. Students who have performance goal characteristics have not mastered the components of mathematical literacy process with the maximum, they are only able to master the ability of using mathematics tool and the other components of mathematical literacy process is quite good.

  17. Electronic structure of Pt-Co cathode catalysts in membrane electrolyte assembly observed by X-ray absorption fine structure spectroscopy with different probing depth

    International Nuclear Information System (INIS)

    Kobayashi, M.; Hidai, S.; Niwa, H.; Harada, Y.; Oshima, M.; Ofuchi, H.; Nakamori, Y.; Aoki, T.

    2010-01-01

    Electronic structures of Pt-Co cathode and Pt-Ru anode catalysts in membrane electrolyte assemblies (MEAs) for polymer electrolyte fuel cell have been investigated using X-ray absorption near edge structure (XANES) spectroscopy, and the changes of electronic structures accompanied with degradation have been observed by comparison between spectra obtained by fluorescence-yield (FY) and conversion-electron-yield (CEY) methods, probing depths of which are several hundreds μm and ∼100 nm, respectively. The Co K XANES spectra of the as-fabricated MEA show that the Co atoms in the cathode are metallic and oxidized Co ions exist at the interface between the cathode and electrolyte. The spectra of the long-time operated MEA suggest that the oxidation of Co makes progress with degradation of the cathode catalysts. In contrast to the Co K XANES spectra, the line shape of the Ru K XANES spectra is unchanged even after the long-time operation.

  18. A Hybrid Robotic Control System Using Neuroblastoma Cultures

    Science.gov (United States)

    Ferrández, J. M.; Lorente, V.; Cuadra, J. M.; Delapaz, F.; Álvarez-Sánchez, José Ramón; Fernández, E.

    The main objective of this work is to analyze the computing capabilities of human neuroblastoma cultured cells and to define connection schemes for controlling a robot behavior. Multielectrode Array (MEA) setups have been designed for direct culturing neural cells over silicon or glass substrates, providing the capability to stimulate and record simultaneously populations of neural cells. This paper describes the process of growing human neuroblastoma cells over MEA substrates and tries to modulate the natural physiologic responses of these cells by tetanic stimulation of the culture. We show that the large neuroblastoma networks developed in cultured MEAs are capable of learning: establishing numerous and dynamic connections, with modifiability induced by external stimuli and we propose an hybrid system for controlling a robot to avoid obstacles.

  19. Equilibrium Solubility of CO2 in Alkanolamines

    DEFF Research Database (Denmark)

    Waseem Arshad, Muhammad; Fosbøl, Philip Loldrup; von Solms, Nicolas

    2014-01-01

    Equilibrium solubility of CO2 were measured in aqueous solutions of Monoethanolamine (MEA) and N,N-diethylethanolamine(DEEA). Equilibrium cells are generally used for these measurements. In this study, the equilibrium data were measured from the calorimetry. For this purpose a reaction calorimeter...... (model CPA 122 from ChemiSens AB, Sweden) was used. The advantage of this method is being the measurement of both heats of absorption and equilibrium solubility data of CO2 at the same time. The measurements were performed for 30 mass % MEA and 5M DEEA solutions as a function of CO2 loading at three...... different temperatures 40, 80 and 120 ºC. The measured 30 mass % MEA and 5M DEEA data were compared with the literature data obtained from different equilibrium cells which validated the use of calorimeters for equilibrium solubility measurements....

  20. CO2 CAPTURE BY ABSORPTION WITH POTASSIUM CARBONATE

    Energy Technology Data Exchange (ETDEWEB)

    Gary T. Rochelle; Marcus Hilliard; Eric Chen; Babatunde Oyenekan; Ross Dugas; John McLees

    2005-07-31

    The objective of this work is to improve the process for CO{sub 2} capture by alkanolamine absorption/stripping by developing an alternative solvent, aqueous K{sub 2}CO{sub 3} promoted by piperazine. The baseline campaign with 30% MEA has given heat duties from 40 to 70 kcal/gmol CO{sub 2} as predicted by the stripper model. The Flexipak 1Y structured packing gives significantly better performance than IMTP 40 duped packing in the absorber, but in the stripper the performance of the two packings is indistinguishable. The FTIR analyzer measured MEA volatility in the absorber represented by an activity coefficient of 0.7. In the MEA campaign the material balance closed with an average error of 3.5% and the energy balance had an average error of 5.9.

  1. The use of regression analysis in determining reference intervals for low hematocrit and thrombocyte count in multiple electrode aggregometry and platelet function analyzer 100 testing of platelet function.

    Science.gov (United States)

    Kuiper, Gerhardus J A J M; Houben, Rik; Wetzels, Rick J H; Verhezen, Paul W M; Oerle, Rene van; Ten Cate, Hugo; Henskens, Yvonne M C; Lancé, Marcus D

    2017-11-01

    Low platelet counts and hematocrit levels hinder whole blood point-of-care testing of platelet function. Thus far, no reference ranges for MEA (multiple electrode aggregometry) and PFA-100 (platelet function analyzer 100) devices exist for low ranges. Through dilution methods of volunteer whole blood, platelet function at low ranges of platelet count and hematocrit levels was assessed on MEA for four agonists and for PFA-100 in two cartridges. Using (multiple) regression analysis, 95% reference intervals were computed for these low ranges. Low platelet counts affected MEA in a positive correlation (all agonists showed r 2 ≥ 0.75) and PFA-100 in an inverse correlation (closure times were prolonged with lower platelet counts). Lowered hematocrit did not affect MEA testing, except for arachidonic acid activation (ASPI), which showed a weak positive correlation (r 2 = 0.14). Closure time on PFA-100 testing was inversely correlated with hematocrit for both cartridges. Regression analysis revealed different 95% reference intervals in comparison with originally established intervals for both MEA and PFA-100 in low platelet or hematocrit conditions. Multiple regression analysis of ASPI and both tests on the PFA-100 for combined low platelet and hematocrit conditions revealed that only PFA-100 testing should be adjusted for both thrombocytopenia and anemia. 95% reference intervals were calculated using multiple regression analysis. However, coefficients of determination of PFA-100 were poor, and some variance remained unexplained. Thus, in this pilot study using (multiple) regression analysis, we could establish reference intervals of platelet function in anemia and thrombocytopenia conditions on PFA-100 and in thrombocytopenia conditions on MEA.

  2. A Scopus-based examination of tobacco use publications in Middle Eastern Arab countries during the period 2003-2012.

    Science.gov (United States)

    Zyoud, Sa'ed H; Al-Jabi, Samah W; Sweileh, Waleed M; Awang, Rahmat

    2014-05-01

    Tobacco smoking is the main health-care problem in the world. Evaluation of scientific output in the field of tobacco use has been poorly explored in Middle Eastern Arab (MEA) countries to date, and there are few internationally published reports on research activity in tobacco use. The main objectives of this study were to analyse the research output originating from 13 MEA countries on tobacco fields and to examine the authorship pattern and the citations retrieved from the Scopus database. Data from 1 January 2003 through 31 December 2012 were searched for documents with specific words regarding the tobacco field as 'keywords' in the title in any 1 of the 13 MEA countries. Research productivity was evaluated based on a methodology developed and used in other bibliometric studies. Five hundred documents were retrieved from 320 peer-reviewed journals. The greatest amount of research activity was from Egypt (25.4%), followed by the Kingdom of Saudi Arabia (KSA) (23.2%), Lebanon (16.3%), and Jordan (14.8%). The total number of citations for the 560 documents, at the time of data analysis (27 August 2013), was 5,585, with a mean ± SD of 9.95 ± 22.64 and a median (interquartile range) of 3(1-10). The h-index of the retrieved documents was 34. This study identified 232 (41.4%) documents from 53 countries in MEA-foreign country collaborations. By region, MEA collaborated most often with countries in the Americas (29.6%), followed by countries in the same MEA region (13.4%), especially KSA and Egypt. The present data reveal a promising rise and a good start for research productivity in the tobacco field in the Arab world. Research output is low in some countries, which can be improved by investing in more international and national collaborative research projects in the field of tobacco.

  3. A Scopus-based examination of tobacco use publications in Middle Eastern Arab countries during the period 2003–2012

    Science.gov (United States)

    2014-01-01

    Background Tobacco smoking is the main health-care problem in the world. Evaluation of scientific output in the field of tobacco use has been poorly explored in Middle Eastern Arab (MEA) countries to date, and there are few internationally published reports on research activity in tobacco use. The main objectives of this study were to analyse the research output originating from 13 MEA countries on tobacco fields and to examine the authorship pattern and the citations retrieved from the Scopus database. Methods Data from 1 January 2003 through 31 December 2012 were searched for documents with specific words regarding the tobacco field as 'keywords’ in the title in any 1 of the 13 MEA countries. Research productivity was evaluated based on a methodology developed and used in other bibliometric studies. Results Five hundred documents were retrieved from 320 peer-reviewed journals. The greatest amount of research activity was from Egypt (25.4%), followed by the Kingdom of Saudi Arabia (KSA) (23.2%), Lebanon (16.3%), and Jordan (14.8%). The total number of citations for the 560 documents, at the time of data analysis (27 August 2013), was 5,585, with a mean ± SD of 9.95 ± 22.64 and a median (interquartile range) of 3(1–10). The h-index of the retrieved documents was 34. This study identified 232 (41.4%) documents from 53 countries in MEA-foreign country collaborations. By region, MEA collaborated most often with countries in the Americas (29.6%), followed by countries in the same MEA region (13.4%), especially KSA and Egypt. Conclusions The present data reveal a promising rise and a good start for research productivity in the tobacco field in the Arab world. Research output is low in some countries, which can be improved by investing in more international and national collaborative research projects in the field of tobacco. PMID:24885706

  4. Effects of scavengers of reactive oxygen and radical species on cell survival following photodynamic treatment in vitro: comparison to ionizing radiation

    International Nuclear Information System (INIS)

    Henderson, B.W.; Miller, A.C.

    1986-01-01

    The effects of various scavengers of reactive oxygen and/or radical species on cell survival in vitro of EMT6 and CHO cells following photodynamic therapy (PDT) or gamma irradiation were compared. None of the agents used exhibited major direct cytotoxicity. Likewise, none interfered with cellular porphyrin uptake, and none except tryptophan altered singlet oxygen production during porphyrin illumination. The radioprotector cysteamine (MEA) was equally effective in reducing cell damage in both modalities. In part, this protection seems to have been induced by oxygen consumption in the system due to MEA autoxidation under formation of H 2 O 2 . The addition of catalase, which prevents H 2 O 2 buildup, reduced the effect of MEA to the same extent in both treatments. Whether the remaining protection was due to MEA's radical-reducing action or some remaining oxygen limitation is unclear. The protective action of MEA was not mediated by a doubling of cellular glutathione levels, since addition of buthionine sulfoximine, which prevented glutathione increase, did not diminish the observed MEA protection. The hydroxyl radical scavenger mannitol also afforded protection in both, but it was approximately twice as effective in gamma irradiation as in PDT. This is consistent with the predominant role of OH radicals in ionizing radiation damage and their presumed minor involvement in PDT damage. Superoxide dismutase, a scavenger of O 2 , acted as a radiation protector but was not significantly effective in PDT. Catalase, which scavenges H 2 O 2 , was ineffective in both modalities. Tryptophan, an efficient singlet oxygen scavenger, reduced cell death through PDT by several orders of magnitude while being totally ineffective in gamma irradiation. These data reaffirm the predominant role of 1O2 in the photodynamic cell killing but also indicate some involvement of free radical species

  5. Advanced Amine Solvent Formulations and Process Integration for Near-Term CO2 Capture Success

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, Kevin S.; Searcy, Katherine; Rochelle, Gary T.; Ziaii, Sepideh; Schubert, Craig

    2007-06-28

    This Phase I SBIR project investigated the economic and technical feasibility of advanced amine scrubbing systems for post-combustion CO2 capture at coal-fired power plants. Numerous combinations of advanced solvent formulations and process configurations were screened for energy requirements, and three cases were selected for detailed analysis: a monoethanolamine (MEA) base case and two “advanced” cases: an MEA/Piperazine (PZ) case, and a methyldiethanolamine (MDEA) / PZ case. The MEA/PZ and MDEA/PZ cases employed an advanced “double matrix” stripper configuration. The basis for calculations was a model plant with a gross capacity of 500 MWe. Results indicated that CO2 capture increased the base cost of electricity from 5 cents/kWh to 10.7 c/kWh for the MEA base case, 10.1 c/kWh for the MEA / PZ double matrix, and 9.7 c/kWh for the MDEA / PZ double matrix. The corresponding cost per metric tonne CO2 avoided was 67.20 $/tonne CO2, 60.19 $/tonne CO2, and 55.05 $/tonne CO2, respectively. Derated capacities, including base plant auxiliary load of 29 MWe, were 339 MWe for the base case, 356 MWe for the MEA/PZ double matrix, and 378 MWe for the MDEA / PZ double matrix. When compared to the base case, systems employing advanced solvent formulations and process configurations were estimated to reduce reboiler steam requirements by 20 to 44%, to reduce derating due to CO2 capture by 13 to 30%, and to reduce the cost of CO2 avoided by 10 to 18%. These results demonstrate the potential for significant improvements in the overall economics of CO2 capture via advanced solvent formulations and process configurations.

  6. Development of integrated DMFC and PEM fuel cell units. Final report; Udvikling af integrerede DMFC og PEM braendselscelle enheder. Slutrapport

    Energy Technology Data Exchange (ETDEWEB)

    Odgaard, M. (IRD Fuel Cell Technology, Svendborg (DK))

    2007-06-15

    The 36-month long project 'Development of integrated DMFC and PEM fuel cell units' has been completed. The project goal was to develop a completely new MEA concept for integrated PEM and DMFC unit cells with enhanced power density and in this way obtain a price reduction. The integrated unit cell consists of a MEA, a gas diffusion layer with flow fields completed with bipolar plates and seals. The main focus of the present project was to: 1) Develop new catalyst materials fabricated by the use of FSD (flame spray deposition method). 2) Optimisation of the state-of-the-art MEA materials and electrode structure. 3) Implementation of a model to account for the CO poisoning of PEM fuel cells. Results and progress obtained in the project established that the individual unit cell components were able to meet and follow the road map of LT-PEM FC regarding electrode catalyst loading and fulfilled the targets for Year 2006. The project has resulted in some important successes. The highlights are as follows: The project has resulted in some important successes. The highlights are as follows: 1) MEA structure knowledge acquired in the project provide a sound basis for further progress. 2) A novel method for the synthesis of electrode by using flame spray synthesis was explored. 3) Electrochemical and catalytic behaviours of catalysts activity for CH{sub 3}OH explored. 4) Implementation of a sub model to account for the CO poisoning of PEM FC has been developed. 5) Numerical study of the flow distribution in FC manifolds was developed and completed with experimental data. 6) The electrode catalyst loading targets for year 2006 achieved. 7) The DMFC MEA performance has been improved by 35%. 8) Optimisation of the MEAs fabrication process has been successfully developed. 9) A new simple flow field design has been designed. 10) A procedure for integrated seals has been developed (au)

  7. High-throughput cardiac safety evaluation and multi-parameter arrhythmia profiling of cardiomyocytes using microelectrode arrays

    Energy Technology Data Exchange (ETDEWEB)

    Gilchrist, Kristin H., E-mail: kgilchrist@rti.org; Lewis, Gregory F.; Gay, Elaine A.; Sellgren, Katelyn L.; Grego, Sonia

    2015-10-15

    Microelectrode arrays (MEAs) recording extracellular field potentials of human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CM) provide a rich data set for functional assessment of drug response. The aim of this work is the development of a method for a systematic analysis of arrhythmia using MEAs, with emphasis on the development of six parameters accounting for different types of cardiomyocyte signal irregularities. We describe a software approach to carry out such analysis automatically including generation of a heat map that enables quick visualization of arrhythmic liability of compounds. We also implemented signal processing techniques for reliable extraction of the repolarization peak for field potential duration (FPD) measurement even from recordings with low signal to noise ratios. We measured hiPS-CM's on a 48 well MEA system with 5 minute recordings at multiple time points (0.5, 1, 2 and 4 h) after drug exposure. We evaluated concentration responses for seven compounds with a combination of hERG, QT and clinical proarrhythmia properties: Verapamil, Ranolazine, Flecainide, Amiodarone, Ouabain, Cisapride, and Terfenadine. The predictive utility of MEA parameters as surrogates of these clinical effects were examined. The beat rate and FPD results exhibited good correlations with previous MEA studies in stem cell derived cardiomyocytes and clinical data. The six-parameter arrhythmia assessment exhibited excellent predictive agreement with the known arrhythmogenic potential of the tested compounds, and holds promise as a new method to predict arrhythmic liability. - Highlights: • Six parameters describing arrhythmia were defined and measured for known compounds. • Software for efficient parameter extraction from large MEA data sets was developed. • The proposed cellular parameter set is predictive of clinical drug proarrhythmia.

  8. Cross Section Measurements for Some Elements Suited as Thermal Spectrum indicators: Cd, Sm, Gd and Lu

    Energy Technology Data Exchange (ETDEWEB)

    Sokolowski, E; Pekarek, H; Jonsson, E

    1964-05-15

    The effective cross sections of Cd, Sm, Gd and Lu have been measured by the oscillator technique in the spectrum of the central channel of the Swedish reactor R1. For Cd, Sm and Gd the 2200 m/s cross sections were deduced on the basis of Westcott's g and s factors. The values obtained were generally in agreement with other recent values obtained by integral methods, although a systematic trend indicated that the value T{sub n} - T{sub m} = 29 {+-} 10 deg C for the neutron spectrum, measured with a fast chopper, was slightly too high. A new value of T{sub n} - T{sub m} = 22.5 {+-} 3.5 deg C was deduced and new 2200 m/s cross sections were obtained by iteration. For natural Lu, the energy dependence of the cross section is not well known. Certain assumptions about the cross section function led to unreasonably high values for the 2200 m/s cross section. Complementary differential measurements of the cross sections of Cd, Sm and Gd were made with the Rl fast chopper. For Cd and Sm the 2200 m/s cross section thus obtained agreed within experimental error with those obtained from the integral measurements. For Gd, the chopper measured value was higher, confirming earlier findings and indicating that the Westcott g factor for Gd is too high. Cd: Integral meas. : {sigma}(2200) = 2,390 {+-} 45 b; Differential meas. : {sigma}(2200) = 2,445 {+-} 25 b; Sm: Integral meas. : {sigma}(2200) = 5,880 {+-} 90 b; Differential meas. : {sigma}(2200) = 5,740 {+-} 150 b; Gd: Integral meas. : {sigma}(2200) = 46,470 {+-} 550 b; Differential meas. : {sigma}(2200) = 47,900 {+-} 700 b.

  9. Cross Section Measurements for Some Elements Suited as Thermal Spectrum indicators: Cd, Sm, Gd and Lu

    Energy Technology Data Exchange (ETDEWEB)

    Sokolowski, E.; Pekarek, H.; Jonsson, E.

    1964-05-15

    The effective cross sections of Cd, Sm, Gd and Lu have been measured by the oscillator technique in the spectrum of the central channel of the Swedish reactor R1. For Cd, Sm and Gd the 2200 m/s cross sections were deduced on the basis of Westcott's g and s factors. The values obtained were generally in agreement with other recent values obtained by integral methods, although a systematic trend indicated that the value T{sub n} - T{sub m} = 29 {+-} 10 deg C for the neutron spectrum, measured with a fast chopper, was slightly too high. A new value of T{sub n} - T{sub m} = 22.5 {+-} 3.5 deg C was deduced and new 2200 m/s cross sections were obtained by iteration. For natural Lu, the energy dependence of the cross section is not well known. Certain assumptions about the cross section function led to unreasonably high values for the 2200 m/s cross section. Complementary differential measurements of the cross sections of Cd, Sm and Gd were made with the Rl fast chopper. For Cd and Sm the 2200 m/s cross section thus obtained agreed within experimental error with those obtained from the integral measurements. For Gd, the chopper measured value was higher, confirming earlier findings and indicating that the Westcott g factor for Gd is too high. Cd: Integral meas. : {sigma}(2200) = 2,390 {+-} 45 b; Differential meas. : {sigma}(2200) = 2,445 {+-} 25 b; Sm: Integral meas. : {sigma}(2200) = 5,880 {+-} 90 b; Differential meas. : {sigma}(2200) = 5,740 {+-} 150 b; Gd: Integral meas. : {sigma}(2200) = 46,470 {+-} 550 b; Differential meas. : {sigma}(2200) = 47,900 {+-} 700 b.

  10. Selective removal of carbon dioxide from wet CO{sub 2}/H{sub 2} mixtures via facilitated transport membranes containing amine blends as carriers

    Energy Technology Data Exchange (ETDEWEB)

    Heydari Gorji, A. [Department of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran (Iran); Kargari, A. [Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran (Iran); Kaghazchi, T.

    2009-01-15

    The selective separation of carbon dioxide (CO{sub 2}) from a wet gaseous mixture of CO{sub 2}/H{sub 2} through facilitated transport membranes containing immobilized aqueous solutions of monoethanolamine (MEA), diethanolamine (DEA), ethylenediamine (EDA) and monoprotonated ethylenediamine (EDAH{sup +}) and their blends was experimentally investigated. The effect of CO{sub 2} partial pressure, amine concentration, feed side pressure and amine species on the CO{sub 2} and H{sub 2} permeances were studied. The CO{sub 2} permeability through amine solution membranes decreased with increasing CO{sub 2} feed partial pressure but the H{sub 2} permeance was almost independent of the H{sub 2} partial pressure. A comparison of experimental results showed that single or blended amines with low viscosity and a moderate equilibrium constant, i.e., large forward and reverse reaction rate of CO{sub 2}-amine, are suitable for effective separation of CO{sub 2}. The permeability of CO{sub 2} generally increased with an increase in amine concentration, although this increase may be compromised by the salting out effect and decrease in diffusivities of species. The results obtained indicated that CO{sub 2} permeance across a variety of amines are in the order of DEA (2 M)>MD(2M) >MD(1 M)>MEA(2 M) >MEA(4 M)>MD (4 M)>DEA (1 M)> DEA(4 M)>MEA (1 M) for various concentrations of MEA+DEA blend and are in the order of EDAH{sup +}(2 M)> DEA(2 M) >MH(2 M)>DH (2 M)>ED (2 M)>EDA (2 M)> MEA(2 M) for various blends of amine. (Abstract Copyright [2009], Wiley Periodicals, Inc.)

  11. The neurotoxic effects of N-methyl-N-nitrosourea on the electrophysiological property and visual signal transmission of rat's retina

    Energy Technology Data Exchange (ETDEWEB)

    Tao, Ye [Department of Ophthalmology, General Hospital of Chinese PLA, Beijing 100853 (China); Chen, Tao [Department of Clinical Aerospace Medicine, Fourth Military Medical University, Xi' an 710032 (China); Liu, Bei [Department of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital, Fourth Military Medical University, Xi' an (China); Yang, Guo Qing [Department of Clinical Aerospace Medicine, Fourth Military Medical University, Xi' an 710032 (China); Peng, Guanghua [Department of Ophthalmology, General Hospital of Chinese PLA, Beijing 100853 (China); Zhang, Hua [Department of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital, Fourth Military Medical University, Xi' an (China); Huang, Yi Fei [Department of Ophthalmology, General Hospital of Chinese PLA, Beijing 100853 (China)

    2015-07-01

    The neurotoxic effects of N-methyl-N-nitrosourea (MNU) on the inner retinal neurons and related visual signal circuits have not been described in any animal models or human, despite ample morphological evidences about the MNU induced photoreceptor (PR) degeneration. With the helping of MEA (multielectrode array) recording system, we gained the opportunity to systemically explore the neural activities and visual signal pathways of MNU administrated rats. Our MEA research identified remarkable alterations in the electrophysiological properties and firstly provided instructive information about the neurotoxicity of MNU that affects the signal transmission in the inner retina. Moreover, the spatial electrophysiological functions of retina were monitored and found that the focal PRs had different vulnerabilities to the MNU. The MNU-induced PR dysfunction exhibited a distinct spatial- and time-dependent progression. In contrast, the spiking activities of both central and peripheral RGCs altered synchronously in response to the MNU administration. Pharmacological tests suggested that gap junctions played a pivotal role in this homogeneous response of RGCs. SNR analysis of MNU treated retina suggested that the signaling efficiency and fidelity of inner retinal circuits have been ruined by this toxicant, although the microstructure of the inner retina seemed relatively consolidated. The present study provided an appropriate example of MEA investigations on the toxicant induced pathological models and the effects of the pharmacological compounds on neuron activities. The positional MEA information would enrich our knowledge about the pathology of MNU induced RP models, and eventually be instrumental for elucidating the underlying mechanism of human RP. - Highlights: • We systemically explored the neural activities and visual signal pathways of MNU administrated retinas. • The focal photoreceptors had different vulnerabilities to the MNU administration.

  12. Pilot-Scale Silicone Process for Low-Cost Carbon Dioxide Capture

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Surinder; Spiry, Irina; Wood, Benjamin; Hancu, Dan; Chen, Wei

    2014-07-01

    This report presents system and economicanalysis for a carbon-capture unit which uses an aminosilicone-based solvent for CO₂ capture in a pulverized coal (PC) boiler. The aminosilicone solvent is a 60/40 wt/wt mixture of 3-aminopropyl end-capped polydimethylsiloxane (GAP-1m) with tri-ethylene glycol (TEG) as a co-solvent. Forcomparison purposes, the report also shows results for a carbon-capture unit based on a conventional approach using mono-ethanol amine (MEA). The first year removal cost of CO₂ for the aminosilicone-based carbon-capture process is $46.04/ton of CO₂ as compared to $60.25/ton of CO₂ when MEA is used. The aminosilicone- based process has <77% of the CAPEX of a system using MEA solvent. The lower CAPEX is due to several factors, including the higher working capacity of the aminosilicone solvent compared the MEA, which reduces the solvent flow rate required, reducing equipment sizes. If it is determined that carbon steel can be used in the rich-lean heat exchanger in the carbon capture unit, the first year removal cost of CO₂ decreases to $44.12/ton. The aminosilicone-based solvent has a higherthermal stability than MEA, allowing desorption to be conducted at higher temperatures and pressures, decreasing the number of compressor stages needed. The aminosilicone-based solvent also has a lowervapor pressure, allowing the desorption to be conducted in a continuous-stirred tank reactor versus a more expensive packed column. The aminosilicone-based solvent has a lowerheat capacity, which decreases the heat load on the desorber. In summary, the amino-silicone solvent has significant advantages overconventional systems using MEA.

  13. The neurotoxic effects of N-methyl-N-nitrosourea on the electrophysiological property and visual signal transmission of rat's retina

    International Nuclear Information System (INIS)

    Tao, Ye; Chen, Tao; Liu, Bei; Yang, Guo Qing; Peng, Guanghua; Zhang, Hua; Huang, Yi Fei

    2015-01-01

    The neurotoxic effects of N-methyl-N-nitrosourea (MNU) on the inner retinal neurons and related visual signal circuits have not been described in any animal models or human, despite ample morphological evidences about the MNU induced photoreceptor (PR) degeneration. With the helping of MEA (multielectrode array) recording system, we gained the opportunity to systemically explore the neural activities and visual signal pathways of MNU administrated rats. Our MEA research identified remarkable alterations in the electrophysiological properties and firstly provided instructive information about the neurotoxicity of MNU that affects the signal transmission in the inner retina. Moreover, the spatial electrophysiological functions of retina were monitored and found that the focal PRs had different vulnerabilities to the MNU. The MNU-induced PR dysfunction exhibited a distinct spatial- and time-dependent progression. In contrast, the spiking activities of both central and peripheral RGCs altered synchronously in response to the MNU administration. Pharmacological tests suggested that gap junctions played a pivotal role in this homogeneous response of RGCs. SNR analysis of MNU treated retina suggested that the signaling efficiency and fidelity of inner retinal circuits have been ruined by this toxicant, although the microstructure of the inner retina seemed relatively consolidated. The present study provided an appropriate example of MEA investigations on the toxicant induced pathological models and the effects of the pharmacological compounds on neuron activities. The positional MEA information would enrich our knowledge about the pathology of MNU induced RP models, and eventually be instrumental for elucidating the underlying mechanism of human RP. - Highlights: • We systemically explored the neural activities and visual signal pathways of MNU administrated retinas. • The focal photoreceptors had different vulnerabilities to the MNU administration.

  14. A simple method to estimate the optimum iodine concentration of contrast material through microcatheters: hydrodynamic calculation with spreadsheet software

    International Nuclear Information System (INIS)

    Yamauchi, Teiyu; Hayashi, Toshihiko; Yamada, Takeshi; Futami, Choichiro; Tsukiyama, Yumiko; Harada, Motoko; Furui, Shigeru; Suzuki, Shigeru; Mimura, Kohshiro

    2008-01-01

    It is important to increase the iodine delivery rate (I), that is the iodine concentration of the contrast material (C) x the flow rate of the contrast material (Q), through microcatheters to obtain arteriograms of the highest contrast. It is known that C is an important factor that influences I. The purpose of this study is to establish a method of hydrodynamic calculation of the optimum iodine concentration (i.e., the iodine concentration at which I becomes maximum) of the contrast material and its flow rate through commercially available microcatheters. Iopamidol, ioversol and iohexol of ten iodine concentrations were used. Iodine delivery rates (I meas) of each contrast material through ten microcatheters were measured. The calculated iodine delivery rate (I cal) and calculated optimum iodine concentration (calculated C opt) were obtained with spreadsheet software. The agreement between I cal and I meas was studied by correlation and logarithmic Bland-Altman analyses. The value of the calculated C opt was within the optimum range of iodine concentrations (i.e. the range of iodine concentrations at which I meas becomes 90% or more of the maximum) in all cases. A good correlation between I cal and I meas (I cal = 1.08 I meas, r = 0.99) was observed. Logarithmic Bland-Altman analysis showed that the 95% confidence interval of I cal/I meas was between 0.82 and 1.29. In conclusion, hydrodynamic calculation with spreadsheet software is an accurate, generally applicable and cost-saving method to estimate the value of the optimum iodine concentration and its flow rate through microcatheters

  15. Defining predictive values using three different platelet function tests for CYP2C19 phenotype status on maintenance dual antiplatelet therapy after PCI.

    Science.gov (United States)

    Zhang, Hong-Zhe; Kim, Moo Hyun; Han, Jin-Yeong; Jeong, Young-Hoon

    2014-01-01

    Published data suggests that the presence of CYP2C19*2 or *3 loss of function (LOF) alleles is indicative of increased platelet aggregation and a higher risk of adverse cardiovascular events after clopidogrel administration. We sought to determine cut-off values using three different assays for prediction of the CYP2C19 phenotype in Korean percutaneous coronary intervention (PCI) patients. We enrolled 244 patients with drug-eluting stent implantation who were receiving clopidogrel and aspirin maintenance therapy for one month or more. Platelet reactivity was assessed with light transmittance aggregometry (LTA), multiple electrode aggregometry (MEA) and the VerifyNow P2Y12 assay (VN). The CYP2C19 genotype was analyzed by polymerase chain reaction (PCR) and snapshot method. The frequency of CYP2C19 LOF allele carriers was 58.6%. The cut-off values from LTA, MEA and VerifyNow for the identification of LOF allele carriers were as follows: 10 µM ADP-induced LTA ≥ 48 %, VN>242 PRU and MEA ≥ 37 U. Between the three tests, correlation was higher between LTA vs. VN assays (r=0.69) and LTA vs. MEA (r=0.56), with moderate agreement (κ=0.46 and κ=0.46), but between VN assay and MEA, both devices using whole blood showed a lower correlation (r=0.42) and agreement (κ=0.3). Our results provide guidance regarding cut-off levels for LTA, VerifyNow and MEA assays to detect the CYP2C19 LOF allele in patients during dual antiplatelet maintenance therapy.

  16. Control and Experimental Characterization of a Methanol Reformer for a 350 W High Temperature Polymer Electrolyte Membrane Fuel Cell system

    DEFF Research Database (Denmark)

    Andreasen, Søren Juhl; Kær, Søren Knudsen; Jensen, Hans-Christian Becker

    , i.e. cathode and anode gas flows and temperature by using mass flow controllers and controlled heaters. Using this system the methanol reformer is characterized in its different operating points, both steady-state but also dynamically. Methanol steam reforming is a well known process, and provides...... and burner and the behaviour of the CO concentration of the reformate gas....... the high temperature waste gas from a cathode air cooled 45 cell HTPEM fuel cell stack. The MEAs used are BASF P2100 which use phosphoric acid doped polybenzimidazole type membranes; an MEA with high CO tolerance and no complex humidity requirements. The methanol reformer used is integrated into a compact...

  17. Dicty_cDB: Contig-U12922-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 2e-11 2 ( EA053492 ) Sequence 221 from patent US 7157621. 62 2e-11 4 ( DY329960 ) OB_MEa0004O04.r OB_MEa Ocimum basil...hql*mvfiknfkkkkkkkk Frame B: llaywxyyyyskyifvyt*niyk*fllvvnfv*lisivsnf*nnkekkngxk...CP001124 |pid:none) Geobacter bemidjiensis Bem, comp... 70 2e-10 (A4JHJ8) RecName...... 56 4e-06 CP000852_1193( CP000852 |pid:none) Caldivirga maquilingensis IC-16... 55 5e-06 ...cc*frfw**awklw*i fr*sk*rgys*icmhfnfignqks*f*tksiinwwwyc*fy*cgchfqryh*sn*rvs** yh*iksfhfr*krwsklsigfttyernws*ity

  18. Dicty_cDB: Contig-U15883-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ndgk*kktrggygcwttniqfnq*ifne* q**fetnigvittfntiisitwfnfdangickcivistinsieyvtfigavlstnvti*k e*kqqk*q*e*iskfrgem...IA --- ---nnnnnnnnnnnkliihksiviiriqhsqivtqlnhtryhtimtigghphlvpkh*fl liiqpiliqlktitifyslmi...ab1. 38 0.33 2 ( DY330556 ) OB_MEa0005L07.f OB_MEa Ocimum basilicum cDNA clon... 38 0.36 2 ( EY305365 ) CAWX...ZGC_9 Danio rerio cDNA clo... 42 1.3 2 ( DY338804 ) OB_SEa09A12.r OB_SEa Ocimum basil...nnnnnnnflmqqhq qyqqqyqlmqqhyqqqlsqqhhqqvwvqiqlhvv*vvvvvvvvvvvvvvvi*pvelnqvv vvveekvdliimvmdmvmdhmvmvvkvqevhvvvniiythiytlnitsivi

  19. IKO

    International Nuclear Information System (INIS)

    1978-01-01

    Experimental work with the old cyclotron was terminated in April 1977, and the new accelerator MEA put into operation. During 1977 the chemistry low energy hall and the electron scattering low energy hall became operational. Much progress was made with the design and construction of the beam handling system and spectrometers for the high energy electron hall. The instrumentation and facilities in the electron scattering areas, the pion muon area, the 100 MeV chemistry area and for the accelerator MEA and technical services are described. Research into electron scattering experiments, pion and muon physics, nuclear theory, nuclear spectroscopy, radio- and nuclear chemistry and nuclear reactions is reported. (C.F.)

  20. Study of coupled heat and water transfer in proton exchange membrane fuel cells by the way of internal measurements

    International Nuclear Information System (INIS)

    Thomas, A; Maranzana, G; Didierjean, S; Dillet, J; Lottin, O

    2012-01-01

    Measurements of electrode temperatures within a proton exchange membrane fuel cell were performed using platinum wires. A temperature difference of 7°C between the electrodes and the bipolar plates was observed for a cell operating at a current density of 1.5 A.cm −2 . These measurements show a strong non-uniformity of the temperature profile through membrane electrode assembly (MEA) that future phenomenological models must take into account. In addition, the simultaneous measurements of heat and water flux through the MEA leads to the conclusion that produced water crosses the diffusion layer in vapor phase. A very simple heat transfer model is proposed.

  1. More electric aircraft starter-generator system with utilization of hybrid modulated model predictive control

    OpenAIRE

    Yoeh, Seang Shen; Yang, Tao; Tarisciotti, Luca; Hill, Christopher Ian; Bozhko, Serhiy

    2016-01-01

    The current trend for future aircraft is the adoption of the More Electric Aircraft (MEA) concept. The electrical based starter-generator (S/G) system is one of the core ideas from the MEA concept. The PI based control scheme has been investigated in various papers for the permanent magnet based S/G system. Different control schemes are to be considered to improve the control performance of the S/G system. A type of non-linear control called Model Predictive Control (MPC) is considered for it...

  2. Biocompatible implants and methods of making and attaching the same

    Energy Technology Data Exchange (ETDEWEB)

    Rowley, Adrian P; Laude, Lucien D; Humayun, Mark S; Weiland, James D; Lotfi, Atoosa; Markland, Jr., Francis S

    2014-10-07

    The invention provides a biocompatible silicone implant that can be securely affixed to living tissue through interaction with integral membrane proteins (integrins). A silicone article containing a laser-activated surface is utilized to make the implant. One example is an implantable prosthesis to treat blindness caused by outer retinal degenerative diseases. The device bypasses damaged photoreceptors and electrically stimulates the undamaged neurons of the retina. Electrical stimulation is achieved using a silicone microelectrode array (MEA). A safe, protein adhesive is used in attaching the MEA to the retinal surface and assist in alleviating focal pressure effects. Methods of making and attaching such implants are also provided.

  3. Kinetic analysis by DSC of the cationic curing of mixtures of DGEBA and 6,6-dimethyl (4,8-dioxaspiro[2.5]octane-5,7-dione)

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, Lidia [Departament de Quimica Analitica i Quimica Organica, Universitat Rovira i Virgili, C/Marcelli Domingo s/n, 43007 Tarragona (Spain); Ramis, Xavier [Laboratori de Termodinamica, ETSEIB, Universitat Politecnica de Catalunya, Av. Diagonal 647, 08028 Barcelona (Spain); Salla, Josep Maria [Laboratori de Termodinamica, ETSEIB, Universitat Politecnica de Catalunya, Av. Diagonal 647, 08028 Barcelona (Spain)], E-mail: salla@mmt.upc.edu; Mantecon, Ana; Serra, Angels [Departament de Quimica Analitica i Quimica Organica, Universitat Rovira i Virgili, C/Marcelli Domingo s/n, 43007 Tarragona (Spain)

    2007-11-25

    The kinetics of the thermal cationic cure reaction of mixtures in different proportions of diglycidylether of bisphenol A (DGEBA) with 6,6-dimethyl (4,8-dioxaspiro[2.5]octane-5,7-dione) (MCP) initiated by ytterbium or lanthanum triflates or using a conventional initiator, BF{sub 3}.MEA was investigated. The non-isothermal differential scanning calorimetry (DSC) experiments at a controlled heating rate was used for obtaining the kinetic parameters of the reactive systems. BF{sub 3}.MEA and lanthanide triflates initiated curing systems follow a complete different kinetic model. Among lanthanide triflates, ytterbium is the most active initiator.

  4. Surface-modified microelectrode array with flake nanostructure for neural recording and stimulation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ju-Hyun; Choi, Yang-Kyu [Nano-Oriented Bio-Electronics Lab, Department of Electrical Engineering, College of Information Science and Technology, KAIST, Daejeon 305-701 (Korea, Republic of); Kang, Gyumin; Nam, Yoonkey, E-mail: ynam@kaist.ac.kr, E-mail: ykchoi@ee.kaist.ac.kr [Department of Bio and Brain Engineering, KAIST, KAIST Institute for Nano-Century, Daejeon 305-701 (Korea, Republic of)

    2010-02-26

    A novel microelectrode modification method is reported for neural electrode engineering with a flake nanostructure (nanoflake). The nanoflake-modified electrodes are fabricated by combining conventional lithography and electrochemical deposition to implement a microelectrode array (MEA) on a glass substrate. The unique geometrical properties of nanoflake sharp tips and valleys are studied by optical, electrochemical and electrical methods in order to verify the advantages of using nanoflakes for neural recording devices. The in vitro recording and stimulation of cultured hippocampal neurons are demonstrated on the nanoflake-modified MEA and the clear action potentials are observed due to the nanoflake impedance reduction effect.

  5. Lowering the platinum loading of high temperature polymer electrolyte membrane fuel cells with acid doped polybenzimidazole membranes

    DEFF Research Database (Denmark)

    Fernandez, Santiago Martin; Li, Qingfeng; Jensen, Jens Oluf

    2015-01-01

    Membrane electrode assemblies (MEAs) with ultra-low Pt loading electrodes were prepared for high temperature polymer electrolyte membrane fuel cells (HT-PEMFCs) based on acid doped polybenzimidazole. With no electrode binders or ionomers, the triple phase boundary of the catalyst layer was establ......Membrane electrode assemblies (MEAs) with ultra-low Pt loading electrodes were prepared for high temperature polymer electrolyte membrane fuel cells (HT-PEMFCs) based on acid doped polybenzimidazole. With no electrode binders or ionomers, the triple phase boundary of the catalyst layer...

  6. [Crex and Orion analysis in radiation oncology: towards a mutualisation of corrective actions].

    Science.gov (United States)

    Lartigau, E; Vitoux, A; Debouck, F

    2009-10-01

    After working on treatment organization in radiotherapy (bonnes pratiques organisationnelles en radiothérapie--action pilote MeaH 2003), the development of a security policy has become crucial. With the help of Air France consulting and the MeaH, three cancer centers in Angers, Lille et Villejuif worked together on the implantation of experience feed back committees (Crex) dedicated to the registration, analysis and correction of precursor events. This action has now been implemented in all the FNCLCC centers. It seems now important to have a program of mutualisation of corrective actions for all participants. This will allow to review the Orion method of events analysis.

  7. MODEL PEMBERDAYAAN WILAYAH PESISIR DALAM MENGHADAPI PASAR BEBAS MASYARAKAT EKONOMI ASEAN

    Directory of Open Access Journals (Sweden)

    Hezron Sabar Rotua Tinambunan

    2016-06-01

    Peran masyarakat sangat dibutuhkan untuk tercapainya pembangunan, karena keberhasilan pembangunan di suatu negara adalah bagaimana pemerintah menentukan model pemberdayaan kepada masyarakatnya. Kebijakan Pemerintah Daerah dalam pembangunan memiliki andil dengan melakukan upaya-upaya serius. Lebih lagi Indonesia menghadapi Masyarakat Ekonomi ASEAN (MEA pada tahun 2016, yang bertujuan sebagai salah satu upaya untuk meningkatkan stabilitas perekonomian di kawasan ASEAN. Kesinambungan antara pemerintah daerah dan masyarakat guna menghadapi tantangan MEA sangat diperlukan. Pemerintah daerah harus membuat regulasi terkait sistem resi gudang guna memangkas jalur tengkulak yang sangat mematikan hasil usaha nelayan dalam menjamin ketersediaan modal usaha untuk produksi yang berkelanjutan dan menstabilkan harga komoditi.

  8. Manufacturing of Low Cost, Durable Membrane Electrode Assemblies Engineered for Rapid Conditioning

    Energy Technology Data Exchange (ETDEWEB)

    Busby, Colin [W. L. Gore & Associates Inc., Newark, DE (United States)

    2017-05-23

    Over the past 20 years significant progress in membrane-electrode assembly (MEA) technology development for polymer electrolyte fuel cells (PEMFCs) has resulted in the PEMFC technology approaching a commercial reality for transportation applications. However, there remain two primary technical challenges to be addressed in the MEA. First and foremost is meeting the automotive cost targets: Producing a fuel cell stack cost competitive with today’s internal combustion engine. In addition to the material cost, MEA (and other components) and stack assembly production methods must be amenable for use in low cost, high speed, automotive assembly line. One impediment to this latter goal is that stack components must currently go through a long and tedious conditioning procedure before they produce optimal power. This so-called “break-in” can take many hours, and can involve quite complex voltage, temperature and/or pressure steps. These break-in procedures must be simplified and the time required reduced if fuel cells are to become a viable automotive engine. The second challenge is to achieve the durability targets in real-world automotive duty cycle operations. Significant improvements in cost, break-in time, and durability for the key component of fuel cell stacks, MEAs were achieved in this project. Advanced modeling was used to guide design of the new MEA to maximize performance and durability. A new, innovative process and manufacturing approach utilizing direct in-line coating using scalable, cost-competitive, continuous high volume 3-layer rolled-good manufacturing processes was developed and validated by single cell and short stack testing. In addition, the direct coating methods employed were shown to reduce the cost for sacrificial films. Furthermore, Gore has demonstrated a 10 µm reinforced membrane that is used in the new low-cost process and can meet automotive power density and durability targets. Across a wide range of operating conditions, the

  9. Final Report - High Performance, Durable, Low Cost Membrane Electrode Assemblies for Transportation Applications

    Energy Technology Data Exchange (ETDEWEB)

    Steinbach, Andrew [3M Company, Maplewood, MN (United States)

    2017-05-31

    The primary project objective was development of improved polymer electrolyte membrane fuel cell (PEMFC) membrane electrode assemblies (MEAs) which address the key DOE barriers of performance, durability and cost. Additional project objectives were to address commercialization barriers specific to MEAs comprising 3M nanostructured thin film (NSTF) electrodes, including a larger-than-acceptable sensitivity to operating conditions, an unexplained loss of rated power capability with operating time, and slow break-in conditioning. Significant progress was made against each of these barriers, and most DOE 2020 targets were met or substantially approached.

  10. Kinetic analysis by DSC of the cationic curing of mixtures of DGEBA and 6,6-dimethyl (4,8-dioxaspiro[2.5]octane-5,7-dione)

    International Nuclear Information System (INIS)

    Gonzalez, Lidia; Ramis, Xavier; Salla, Josep Maria; Mantecon, Ana; Serra, Angels

    2007-01-01

    The kinetics of the thermal cationic cure reaction of mixtures in different proportions of diglycidylether of bisphenol A (DGEBA) with 6,6-dimethyl (4,8-dioxaspiro[2.5]octane-5,7-dione) (MCP) initiated by ytterbium or lanthanum triflates or using a conventional initiator, BF 3 .MEA was investigated. The non-isothermal differential scanning calorimetry (DSC) experiments at a controlled heating rate was used for obtaining the kinetic parameters of the reactive systems. BF 3 .MEA and lanthanide triflates initiated curing systems follow a complete different kinetic model. Among lanthanide triflates, ytterbium is the most active initiator

  11. CO2 Capture from Flue gas using Amino acid salt solutions

    DEFF Research Database (Denmark)

    Lerche, Benedicte Mai

    to storage. Typical solvents for the process are based on aqueous solutions of alkanolamines, such as mono-ethanolamine (MEA), but their use implies economic disadvantages and environmental complications. Amino acid salt solutions have emerged as an alternative to the alkanolamines, partlybecause...... for measuring of CO2 solubility based on the semi-flow method. A validation study of CO2 solubility in aqueous solutions of MEA is presented. Chapter 5 focuses on the determination of the chemical compositions of the precipitations, which arise in the five amino acid salt solutions upon CO2 absorption...

  12. The rationalization of desulfurization by on-line analysis

    Energy Technology Data Exchange (ETDEWEB)

    Murakami, Y; Kohmura, S; Taketomi, H; Matsumura, S; Sasaki, Y

    1986-01-01

    Nippon Kokan uses the Takahax and Sulfiban processes for the desulfurization of coke oven gas. The authors outline the Sulfiban Process and describe a recently developed system for the on-line determination of H/sub 2/S in coke oven gas, and of CO/sub 2/ and monoethanolamine (MEA) in the wash oil. This new on-line analysis system has proved effective in rationalizing the Sulfiban Process via lower MEA production costs and decreased power consumption. The introduction of a computerized control system is now being studied. 7 figs., 4 tabs.

  13. Micromachined three-dimensional electrode arrays for transcutaneous nerve tracking

    Science.gov (United States)

    Rajaraman, Swaminathan; Bragg, Julian A.; Ross, James D.; Allen, Mark G.

    2011-08-01

    We report the development of metal transfer micromolded (MTM) three-dimensional microelectrode arrays (3D MEAs) for a transcutaneous nerve tracking application. The measurements of electrode-skin-electrode impedance (ESEI), electromyography (EMG) and nerve conduction utilizing these minimally invasive 3D MEAs are demonstrated in this paper. The 3D MEAs used in these measurements consist of a metalized micro-tower array that can penetrate the outer layers of the skin in a painless fashion and are fabricated using MTM technology. Two techniques, an inclined UV lithography approach and a double-side exposure of thick negative tone resist, have been developed to fabricate the 3D MEA master structure. The MEAs themselves are fabricated from the master structure utilizing micromolding techniques. Metal patterns are transferred during the micromolding process, thereby ensuring reduced process steps compared to traditional silicon-based approaches. These 3D MEAs have been packaged utilizing biocompatible Kapton® substrates. ESEI measurements have been carried out on test human subjects with standard commercial wet electrodes as a reference. The 3D MEAs demonstrate an order of magnitude lower ESEI (normalized to area) compared to wet electrodes for an area that is 12.56 times smaller. This compares well with other demonstrated approaches in literature. For a nerve tracking demonstration, we have chosen EMG and nerve conduction measurements on test human subjects. The 3D MEAs show 100% improvement in signal power and SNR/√area as compared to standard electrodes. They also demonstrate larger amplitude signals and faster rise times during nerve conduction measurements. We believe that this microfabrication and packaging approach scales well to large-area, high-density arrays required for applications like nerve tracking. This development will increase the stimulation and recording fidelity of skin surface electrodes, while increasing their spatial resolution by an order of

  14. Micromachined three-dimensional electrode arrays for transcutaneous nerve tracking

    International Nuclear Information System (INIS)

    Rajaraman, Swaminathan; Allen, Mark G; Bragg, Julian A; Ross, James D

    2011-01-01

    We report the development of metal transfer micromolded (MTM) three-dimensional microelectrode arrays (3D MEAs) for a transcutaneous nerve tracking application. The measurements of electrode–skin–electrode impedance (ESEI), electromyography (EMG) and nerve conduction utilizing these minimally invasive 3D MEAs are demonstrated in this paper. The 3D MEAs used in these measurements consist of a metalized micro-tower array that can penetrate the outer layers of the skin in a painless fashion and are fabricated using MTM technology. Two techniques, an inclined UV lithography approach and a double-side exposure of thick negative tone resist, have been developed to fabricate the 3D MEA master structure. The MEAs themselves are fabricated from the master structure utilizing micromolding techniques. Metal patterns are transferred during the micromolding process, thereby ensuring reduced process steps compared to traditional silicon-based approaches. These 3D MEAs have been packaged utilizing biocompatible Kapton® substrates. ESEI measurements have been carried out on test human subjects with standard commercial wet electrodes as a reference. The 3D MEAs demonstrate an order of magnitude lower ESEI (normalized to area) compared to wet electrodes for an area that is 12.56 times smaller. This compares well with other demonstrated approaches in literature. For a nerve tracking demonstration, we have chosen EMG and nerve conduction measurements on test human subjects. The 3D MEAs show 100% improvement in signal power and SNR/√area as compared to standard electrodes. They also demonstrate larger amplitude signals and faster rise times during nerve conduction measurements. We believe that this microfabrication and packaging approach scales well to large-area, high-density arrays required for applications like nerve tracking. This development will increase the stimulation and recording fidelity of skin surface electrodes, while increasing their spatial resolution by an order

  15. Study for increasing the stabilization time of a catalytic dye to facilitate the fabrication of membrane electrode assemblies; Estudio para incrementar el tiempo de estabilizacion de una tinta catalitica para facilitar la fabricacion de ensambles membrana-electrodo

    Energy Technology Data Exchange (ETDEWEB)

    Flores Hernandez, J. Roberto [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico)] e-mail: jrflores@iie.org.mx; Martinez Vado, F. Isaias [Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Mexico D.F. (Mexico); Cano Castillo, Ulises, Albarran Sanchez, Lorena [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico)

    2009-09-15

    An infrastructure project has been underway for hydrogen technology and fuel cells at the Electrical Research Institute (IIE, Spanish acronym). Part of this project is an activity for the fabrication of membrane electrode assemblies (MEA). Currently, a fabrication process is well-established for the MEA using the spray technique. In addition, a catalytic dye base composition has been developed for use in the fabrication of high-quality MEA with a good degree of reproducibility. Nevertheless, the instability of the dye over time prevents continuous fabrication of MEA. This document presents the results obtained, to-date, of research conducted at the IIE aimed at increasing the stability of the catalytic dye by adding a surfactant with different concentrations and increasing the concentration of the Nafion® solution. It was found that the effect of adding the surfactant to the catalytic dye results in a qualitative decrease in the agglomerate sizes, while also decreasing the porosity of the dye once it has dried. In addition, it was found that increasing the amount of Nafion® in the catalytic die increases the porosity. [Spanish] En el Instituto de Investigaciones Electricas (IIE) se ha venido trabajando en un proyecto de infraestructura sobre la tecnologia de hidrogeno y celdas de combustible. Dentro de este proyecto se tiene una actividad orientada a la fabricacion de Ensambles Membrana-Electrodo (MEA's). Actualmente se tiene un proceso de fabricacion bien establecido para la elaboracion de MEA's utilizando la tecnica de rociado, asimismo, se tiene una composicion base de tinta catalitica con la cual se fabrican MEA's de buena calidad y con buen grado de reproducibilidad. Sin embargo, la inestabilidad de la tinta con respecto al tiempo impide tener una fabricacion continua de los MEA's. En este documento se presentan los resultados obtenidos hasta ahora de una investigacion que se realiza en el IIE orientada a incrementar la estabilidad de la

  16. Electrochemical atomic layer deposition of Pt nanostructures on fuel cell gas diffusion layer

    CSIR Research Space (South Africa)

    Modibedi, M

    2010-12-01

    Full Text Available and test MEA?s performance in PEMFC. BIBLIOGRAPHY 1. Barbir F., (2005) PEM Fuel Cells: Theory and Practice, Elsevier Academic Press Oxford. 2. Yang T.-H., et al (2004) J. Power Sources 127 230. 3. Hirano S., Kim J. and Srinivasan S., (1997) Electrochim... stream_source_info Modibedi_2010.pdf.txt stream_content_type text/plain stream_size 5644 Content-Encoding ISO-8859-1 stream_name Modibedi_2010.pdf.txt Content-Type text/plain; charset=ISO-8859-1 RESULTS AND DISCUSSIONS...

  17. Durability of Carbon Nanofiber (CNF) & Carbon Nanotube (CNT) as Catalyst Support for Proton Exchange Membrane Fuel Cells

    DEFF Research Database (Denmark)

    Andersen, Shuang Ma; Borghei, Maryam; Lund, Peter

    2013-01-01

    a standard polyol method were prepared and fabricated as cathodes of Membrane Electrode Assemblies (MEA) for PEMFC. Both the catalysts as such and the MEAs made out of them were evaluated regarding to thermal and electrochemical stability using traditional carbon black (Vulcan XC72) as a reference. Thermal...... gravimetric analysis (TGA), cyclic voltammetry (CV), polarization curve and impedance spectroscopy were applied on the samples under accelerated stress conditions. The carbon nano-materials demonstrated better stability as support for nano-sized platinum catalyst under PEMFC related operating conditions. Due...

  18. Desenvolvimento de conjunto membrana-eletrodos para célula a combustível de metanol direto passiva Development of membrane electrode assembly for passive direct methanol fuel cell

    Directory of Open Access Journals (Sweden)

    Eli Carlos Lisboa Ferreira

    2010-01-01

    Full Text Available Direct methanol fuel cells (DMFCs without external pumps or other ancillary devices for fuel and oxidant supply are known as passive DMFCs and are potential candidates to replace lithium-ion batteries in powering portable electronic devices. This paper presents the results obtained from a membrane electrode assembly (MEA specifically designed for passive DMFCs. Appropriated electrocatalysts were prepared and the effect of their loadings was investigated. Two types of gas diffusion layers (GDL were also tested. The influence of the methanol concentration was analyzed in each case. The best MEA performance presented a maximum power density of 11.94 mW cm-2.

  19. The value of innovation in decision-making in health care in Central Eastern Europe - The Sixth International Conference, 2 June 2017, Belgrade, Serbia.

    Science.gov (United States)

    Novakovic, Tanja; Martin, Antony P; Parker, Mark; Ferrario, Alessandra; Vukovic, Simo; Łanda, Krzysztof; Duba, Jaroslav; Dankó, Dávid; Kotsopoulos, Nikolaos; Godman, Brian; Ristic, Jelena; Stefanovic, Danka; Tesic, Danka

    2017-12-01

    The Pharmacoeconomics Section of the Pharmaceutical Association of Serbia organised a one day international conference on the value of innovation in decision-making in health care in Central and Eastern Europe. The focus of the conference was on reimbursement decisions for medicines using health technology assessment and the use of managed entry agreements (MEAs). The objectives of this conference were firstly to discuss the challenges and opportunities with the use of MEAs in Central and Eastern European countries; secondly the role of patient registries especially with outcome based schemes, and finally new approaches to improve accessibility to new medicines including better managing their entry.

  20. Modification of porosity in the catalyst layer of membrane electrode assemblies using pore-forming agents; Modificacion de la porosidad en la capa catalitica de ensambles membrana-electrodo empleando agentes formadores de poros

    Energy Technology Data Exchange (ETDEWEB)

    Flores Hernandez, J. Roberto [Instituto de Investigaciones Electricas Cuernavaca, Morelos (Mexico)] e-mail: jrflores@iie.org.mx; Reyes, Brenda [UNAM. Facultad de Quimica, Mexico D.F. (Mexico); Barbosa P., Romeli [Centro de Investigacion en Energia, UNAM, Temixco, Morelos (Mexico); Cano Castillo, Ulises; Albarran, Lorena [Instituto de Investigaciones Electricas Cuernavaca, Morelos (Mexico)

    2009-09-15

    Membrane electrode assemblies (MEA) are the most important part of PEM fuel cells since their interface results in the electrochemical reactions that make the generation of electricity possible. The MEA is composed of a proton exchange membrane, both sides of which are impregnated with a catalyst layer, normally of carbon-supported platinum. Depending on the technique used for its fabrication (atomization, serigraphy, brush methods, chemical reduction, etc.), the properties of the MEA can be different in terms of porosity, distribution of the catalyst, thickness and structure of the catalyst layer, and the quality of the union between the catalyst layer and the membrane, etc. Currently, the porosity of the electrodes is generated by isopropanol evaporation (solvent used in the dye) during the fabrication process conducted in the Instituto de Investigaciones Electricas (IIE). This document presents the results obtained from adding a porous agent to the catalytic dye base composition used in the fabrication of MEA at the IIE. [Spanish] Los Ensambles Membrana-Electrodo (MEA's) son la parte mas importante en las celdas de combustibles tipo PEM, ya que en su interfaz se llevan a cabo las reacciones electroquimicas que hacen posible la generacion de electricidad. El MEA esta compuesto de una membrana de intercambio protonico a la cual se le impregna en ambos lados una capa catalitica normalmente de platino soportado en carbon. Dependiendo de la tecnica empleada en su fabricacion (atomizado, serigrafia, brocha, reduccion quimica, etc.), las propiedades del MEA pueden ser diferentes en cuanto a porosidad, distribucion del catalizador, grosor y estructura de la capa catalitica, asi como la calidad de la union entre la capa catalizadora y la membrana, etc. Actualmente, la porosidad de los electrodos es generada por la evaporacion del isopropanol (solvente utilizado en la tinta) durante el proceso de fabricacion que se realiza en el Instituto de Investigaciones

  1. Modelling of Apple Scab Using Adaptive Network -Based Fuzzy ...

    African Journals Online (AJOL)

    Furkan

    2013-08-28

    Aug 28, 2013 ... A new prediction model for the early warning of apple scab is proposed in this study. The method is .... Instead of all 12-min measurements, the average values of mea- surements in .... ANFC_LH, MLPN, and Bayes for comparison. The Bayes .... Multi metric evaluation of leaf wetness models for large-area.

  2. Experiment and model for the surface tension of amine–ionic liquids aqueous solutions

    International Nuclear Information System (INIS)

    Zhang, Pan; Du, LeiXia; Fu, Dong

    2014-01-01

    Highlights: • The surface tensions of MEA/DEA–ionic liquids aqueous solutions were measured. • The experiments were modeled satisfactorily by using a thermodynamic equation. • The temperature dependence of the surface tension was illustrated. • The effects of the mass fractions of MEA/DEA and ionic liquids were demonstrated. - Abstract: The surface tension (γ) of 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim][BF 4 ])–monoethanolamine (MEA), 1-butyl-3-methylimidazolium bromide ([Bmim][Br])–MEA, [Bmim][BF 4 ]–diethanolamine (DEA) and [Bmim][Br]–DEA aqueous solutions was measured by using the BZY-1 surface tension meter. The temperature ranged from (293.2 to 323.2) K. The mass fraction of amines and ionic liquids (ILS) respectively ranged from 0.15 to 0.30 and 0.05 to 0.10. A thermodynamic equation was proposed to model the surface tension of amines–ILS aqueous solutions and the calculated results agreed well with the experiments. The effects of temperature, mass fraction of amines and ILS on the surface tension were demonstrated on the basis of experiments and calculations

  3. Application of association models to mixtures containing alkanolamines

    DEFF Research Database (Denmark)

    Avlund, Ane Søgaard; Eriksen, Daniel Kunisch; Kontogeorgis, Georgios

    2011-01-01

    Two association models,the CPA and sPC-SAFT equations of state, are applied to binarymixtures containing alkanolamines and hydrocarbons or water. CPA is applied to mixtures of MEA and DEA, while sPC-SAFT is applied to MEA–n-heptane liquid–liquid equilibria and MEA–water vapor–liquid equilibria. T...

  4. Aspergillus europaeus sp. nov., a widely distributed soil-borne species related to A. wentii (section Cremei)

    DEFF Research Database (Denmark)

    Hubka, Vit; Nováková, Alena; Samson, Robert A.

    2016-01-01

    A new species belonging to Aspergillus section Cremei is described, A. europaeus sp. nov. This species is most closely related to A. wentii, A. dimorphicus, and A. chrysellus and can be distinguished by an unique phenotype (colour of sporulation, production of yellow soluble pigment on MEA, shape...

  5. Solar Walls for concrete renovation

    DEFF Research Database (Denmark)

    Gramkow, Lotte; Vejen, Niels Kristian; Olsen, Lars

    1996-01-01

    This repport gives a short presentation of three full-scale testing solar walls, the construction including the architectural design, materials and components, transportation and storage of solar enegy, the effect on the construction behind, statics and practical experience.The results of the mea...

  6. Rehabilitation of community-owned, mixed-use rangelands: Lessons from the Ewaso ecosystem in Kenya

    Science.gov (United States)

    Globally, 10-20% of arid and semi-arid rangelands have been classified as severely degraded (UNCCD 1994; MEA 2005), and in sub-Saharan Africa specifically, 70% of rangelands are considered moderately to severely degraded (Dregne 1992; UNCCD 1994). Given that these drylands make up 43% of Africa’s la...

  7. Probabilistic estimation of residential air exchange rates for population-based human exposure modeling

    Science.gov (United States)

    Residential air exchange rates (AERs) are a key determinant in the infiltration of ambient air pollution indoors. Population-based human exposure models using probabilistic approaches to estimate personal exposure to air pollutants have relied on input distributions from AER meas...

  8. Staff knowledge, attitudes and practices in public sector primary care ...

    African Journals Online (AJOL)

    d S years, years ceptible). luation of frican tudy. The are higher f exposures .... PHCNs 40%, RNs 43 % and SNs 50%), 23% prevention of ..... Mea 1990. 7: 360 ... Improvong Health Care '''rough CI,mcal AUd,t CIT'Cl1ester- John W'ley ana Sons.

  9. Boswellia papyrifera

    African Journals Online (AJOL)

    user

    on Tapped Boswellia papyrifera Trees in Metema and. Humera Districts .... produced on the colony growing on MEA and the spore produced on Water Agar (WA) .... Degraded forests in Eastern Africa: Management and restoration. Earthscan ... deciduous Boswellia woodland in central and western Tigray, Ethiopia.

  10. Estimating the burden of disease attributable to high cholesterol in

    African Journals Online (AJOL)

    High cholesterol is an important cardiovascular risk factor in all population groups in South Africa. S Afr Mea12007; 97: 708—715. The value of abnormal blood lipids and apo—lipoprotein levels to predict ischaemic heart disease (IHD) has been studied for decades, with the initial focus shifting from studying the relationship ...

  11. Developments for improved direct methanol fuel cell stacks for portable power

    Energy Technology Data Exchange (ETDEWEB)

    Cremers, C.; Stimming, U. [Bavarian Center for Applied Energy Research, ZAE Bayern, Abteilung 1, Walther-Meissner-Str. 6, D-85748 Garching (Germany); Technische Universitaet Muenchen, Department of Physics E19, James-Franck-Str. 1, D-85748 Garching (Germany); Scholz, M.; Seliger, W. [Bavarian Center for Applied Energy Research, ZAE Bayern, Abteilung 1, Walther-Meissner-Str. 6, D-85748 Garching (Germany); Racz, A. [Technische Universitaet Muenchen, Department of Physics E19, James-Franck-Str. 1, D-85748 Garching (Germany); Knechtel, W.; Rittmayr, J.; Grafwallner, F.; Peller, H. [ET EnergieTechnologie GmbH, Eugen-Saenger-Ring 4, D-85649 Brunnthal-Nord (Germany)

    2007-02-15

    Different aspects of the improvement of direct methanol fuel cell (DMFC) systems for portable power generation are investigated, in a project funded by the Bavarian state. The materials research focuses on the development of improved catalysts, in particular for the oxygen reduction reaction. Some recent results on supported ruthenium selenium catalysts are reported. In parallel, tests on other fuel cell materials are performed using MEAs made from industrial unsupported catalysts as the reference. These standard MEAs have catalyst loadings of about 11 mg cm{sup -2} and, at high air flux, can deliver current densities of about 500 mA cm{sup -2} and 100 mA cm{sup -2} at 110 C and 50 C, respectively. At low air flux and 50 C, current densities between 60 and 80 mA cm{sup -2} are possible rate at 500 mV. Using these MEAs, different commercial gas diffusion materials are tested as the cathode backing. Thus, it is found that the Sigracet materials by SGL Carbon are the most suitable for operation at a low air flux. Finally, a demonstration stack, comprised of up to ten cells, is developed using graphite PVDF compound bipolar plates by SGL Carbon. As will be reported, this stack shows a high homogeneity of cell voltages and stable operation under relevant conditions, using standard MEAs. (Abstract Copyright [2007], Wiley Periodicals, Inc.)

  12. Recent Intensified Winter Coldness in the Mid-High Latitudes of Eurasia and Its Relationship with Daily Extreme Low Temperature Variability

    Directory of Open Access Journals (Sweden)

    Chuhan Lu

    2016-01-01

    Full Text Available Observational records in recent decades show a large-scale decrease in the cold-season temperature variance in the Northern Hemisphere midlatitudes under continuous global warming. However, severe low temperature events in winter frequently occurred in midlatitude Eurasia (MEA in the last decade. Here, we define a new coldness intensity (CI index for the near-surface based on the amplitude of daily anomalously cold temperatures in winter to demonstrate the CI of the variability of low temperature extremes. The results show that a sign-consistent mode dominates the CI variation in MEA, with a marked intensification during the last decade via empirical orthogonal function (EOF analysis. This leading mode is significantly related to the frequency of winter extreme events. The associated circulations are characterized by a remarkable anomalous anticyclone in Northwest Eurasia, which induced substantial cold advection in MEA. The widespread intensified CI in MEA is closely linked with strong surface anticyclones and synoptic blocking in the mid-high latitudes (25°E–85°E. Coincidently, positive phase shifts of the first two leading modes of the extratropical circulation, which feature similar blocking-like anomalies in the northwestern Eurasian subarctic, jointly play an important role in the recent frequency of severe winters.

  13. Construction of a specification from its singleton part

    NARCIS (Netherlands)

    Fernández, R.; Maillard, G.

    2006-01-01

    We state a construction theorem for specications starting from single-site conditional probabilities (singleton part). We consider general single-site spaces and kernels that are absolutely continuous with respect to a chosen product mea- sure (free measure). Under a natural order-consistency

  14. Eichhornia crassipes

    African Journals Online (AJOL)

    2017-01-01

    Jan 1, 2017 ... Keywords: sustainability, water resources, water hyacinth, water loss, externality, benefit, control ... Millennium Ecosystem Assessment (MEA) identified invasive species as one of five of the .... The ET rate of any hydrophyte is difficult to measure and is dependent on ..... URL: http://horizon.documentation.ird.

  15. Coordination structure of adsorbed Zn(II) at Water-TiO2 interfaces

    Energy Technology Data Exchange (ETDEWEB)

    He, G.; Pan, G.; Zhang, M.; Waychunas, G.A.

    2011-01-15

    The local structure of aqueous metal ions on solid surfaces is central to understanding many chemical and biological processes in soil and aquatic environments. Here, the local coordination structure of hydrated Zn(II) at water-TiO{sub 2} interfaces was identified by extended X-ray absorption fine structure (EXAFS) and X-ray absorption near-edge structure (XANES) spectroscopy combined with density functional theory (DFT) calculations. A nonintegral coordination number of average {approx}4.5 O atoms around a central Zn atom was obtained by EXAFS analysis. DFT calculations indicated that this coordination structure was consistent with the mixture of 4-coordinated bidentate binuclear (BB) and 5-coordinated bidentate mononuclear (BM) metastable equilibrium adsorption (MEA) states. The BB complex has 4-coordinated Zn, while the monodentate mononuclear (MM) complex has 6-coordinated Zn, and a 5-coordinated adsorbed Zn was found in the BM adsorption mode. DFT calculated energies showed that the lower-coordinated BB and BM modes were thermodynamically more favorable than the higher-coordinated MM MEA state. The experimentally observed XANES fingerprinting provided additional direct spectral evidence of 4- and 5-coordinated Zn-O modes. The overall spectral and computational evidence indicated that Zn(II) can occur in 4-, 5-, and 6-oxygen coordinated sites in different MEA states due to steric hindrance effects, and the coexistence of different MEA states formed the multiple coordination environments.

  16. On the absolute measure of Beta activities

    International Nuclear Information System (INIS)

    Sanchez del Rio, C.; Jimenez Reynaldo, O.; Rodriguez Mayquez, E.

    1956-01-01

    A new method for absolute beta counting of solid samples is given. The mea surements is made with an inside Geiger-Muller tube of new construction. The backscattering correction when using an infinite thick mounting is discussed and results for different materials given. (Author)

  17. Distinguishing bovine fecal matter on spinach leaves using field spectroscopy

    Science.gov (United States)

    Detection of fecal contaminants on leafy greens in the field will allow for decreasing cross-contamination of produce during and post-harvest. Fecal contamination of leafy greens has been associated with E.coli O157:H7 outbreaks and foodbourne illnesses. In this study passive field spectroscopy, mea...

  18. A COMPARISON OF THREE ASSAY PROCEDURES FOR DETERMINING CHLORINE INACTIVATION OF WATERBORNE PATHOGENIC BACTERIA

    Science.gov (United States)

    One criterion on which chlorine treatment of water may be based is the concentration (C) in mg/l multiplied by the time (t) in min of exposure or Ct values. We compared different Ct values on waterborne pathogenic bacteria by cultural assay for viability and 2 assays that mea...

  19. Modeling Water Filtration

    Science.gov (United States)

    Parks, Melissa

    2014-01-01

    Model-eliciting activities (MEAs) are not new to those in engineering or mathematics, but they were new to Melissa Parks. Model-eliciting activities are simulated real-world problems that integrate engineering, mathematical, and scientific thinking as students find solutions for specific scenarios. During this process, students generate solutions…

  20. Electrophysiologic studies of neronal activities under ischemia condition.

    Science.gov (United States)

    Huang, Shun-Ho; Wang, Ping-Hsien; Chen, Jia-Jin Jason

    2008-01-01

    Substrate with integrated microelectrode arrays (MEAs) provides an alternative electrophysiological method. With MEAS, one can measure the impedance and elicit electrical stimulation from multiple sites of MEAs to determine the electrophysiological conditions of cells. The aims of this research were to construct an impedance and action potential measurement system for neurons cultured on MEAs for observing the electrophysiological signal transmission in neuronal network during glucose and oxygen deprivation (OGD). An extracellular stimulator producing the biphasic micro-current pulse for neuron stimulation was built in this study. From the time-course recording of impedance, OGD condition effectively induced damage in neurons in vitro. It is known that the results of cell stimulation are affected by electrode impedance, so does the result of neuron cells covered on the electrode can measure the sealing resistance. For extracellular stimulation study, cortical neuronal activity was recorded and the suitable stimulation window was determined. However, the stimulation results were affected by electrode impedance as well as sealing impedance resulting from neuron cells covering the electrode. Further development of surface modification for cultured neuron network should provide a better way for in vitro impedance and electrophysiological measurements.

  1. Cumulative soil water evaporation as a function of depth and time

    Science.gov (United States)

    Soil water evaporation is an important component of the surface water balance and the surface energy balance. Accurate and dynamic measurements of soil water evaporation enhance the understanding of water and energy partitioning at the land-atmosphere interface. The objective of this study is to mea...

  2. Volumetric and viscometric properties of binary and ternary mixtures of 1-butyl-3-methylimidazolium tetrafluoroborate, monoethanolamine and water

    International Nuclear Information System (INIS)

    Yin, Yaran; Zhu, Chunying; Ma, Youguang

    2016-01-01

    Highlights: • Densities and viscosities of [Bmim][BF 4 ] + MEA + H 2 O solutions were measured. • Volumetric and viscometric properties were deduced from experimental results. • Intermolecular interactions were analysed by volumetric and viscometric properties. - Abstract: Densities and viscosities of binary {[Bmim][BF 4 ] + H 2 O}, {[Bmim][BF 4 ] + MEA}, (MEA + H 2 O) and ternary mixtures {[Bmim][BF 4 ] + MEA + H 2 O} were measured at T = (293.15–333.15) K. The volumetric and viscometric properties, such as excess molar volume V E , viscosity deviation Δη, and excess Gibbs energy of activation of viscous flow ΔG ∗E for all mixtures, and apparent molar volume, excess partial molar volume and Grunberg-Nissan interaction parameter G 12 for binary mixtures, were deduced from experimental results, and the intermolecular interactions in solutions were also analysed. The excess molar volumes were correlated using the Redlich-Kister polynomial equation for binary mixtures, and Singh et al. equation for the ternary mixture with corresponding binary parameters. The viscosities of binary and ternary solutions were respectively fitted by Jouyban-Acree equation and its extended equation at each measurement temperature, the correlated values are in good agreement with the corresponding experimental data.

  3. Comparison between TRMM PR and

    Indian Academy of Sciences (India)

    A comparison between TRMM PR rainfall estimates and rain gauge data from ANEEL and com- bined gauge/satellite ..... correctly the of the south Atlantic convergence ..... vapor, snow cover, and sea ice derived from SSM/I mea- surements ...

  4. Evaluation of the effectiveness of selected measures against Bovine Spongiform Encephalopathy (BSE) in Switzerland by use of the basic reproduction ratio R0

    NARCIS (Netherlands)

    Schwermer, H.; Brülisauer, F.; Koeijer, de A.A.; Heim, D.

    2007-01-01

    The effectiveness of two measures against Bovine Spongiform Encephalopathy (BSE), the compulsory processing of animal by products to meat and bone mea (MBM) at 133 °C under 3 bars of pressure for 20 minutes in February 1993 and the exclusion offallen stock, heads with eyes and spinal cord of cattle

  5. Chronic 14-day exposure to insecticides or methylmercury modulates neuronal activity in primary rat cortical cultures

    NARCIS (Netherlands)

    Dingemans, Milou; Schütte, Marijke G; Wiersma, Daphne M M; de Groot, Aart; van Kleef, Gina; Wijnolts, Fiona; Westerink, Remco

    2016-01-01

    There is an increasing demand for in vitro test systems to detect neurotoxicity for use in chemical risk assessment. In this study, we evaluated the applicability of rat primary cortical cultures grown on multi-well micro-electrode arrays (mwMEAs) to detect effects of chronic 14-day exposure to

  6. QTL list: bV-M.2 [PGDBj Registered plant list, Marker list, QTL list, Plant DB link and Genome analysis methods[Archive

    Lifescience Database Archive (English)

    Full Text Available QT96630 Fragaria x ananassa Rosaceae bV-M.2 fruit color external fruit color, meas...ured by Minolta chromameter using CIELAB color space values: b* (blue-yellow spectrum) 1 ... 1 3.86 ... 10.1007/s00122-011-1624-6 21667037

  7. QTL list: aV-M.2 [PGDBj Registered plant list, Marker list, QTL list, Plant DB link and Genome analysis methods[Archive

    Lifescience Database Archive (English)

    Full Text Available QT96624 Fragaria x ananassa Rosaceae aV-M.2 fruit color external fruit color, meas...ured by Minolta chromameter using CIELAB color space values: a* (green-red spectrum) 1 ... 1 4.68 ... 10.1007/s00122-011-1624-6 21667037

  8. QTL list: aV-M.2 [PGDBj Registered plant list, Marker list, QTL list, Plant DB link and Genome analysis methods[Archive

    Lifescience Database Archive (English)

    Full Text Available QT96622 Fragaria x ananassa Rosaceae aV-M.2 fruit color external fruit color, meas...ured by Minolta chromameter using CIELAB color space values: a* (green-red spectrum) 1 ... 2 2.11 ... 10.1007/s00122-011-1624-6 21667037

  9. Linear Viscoelastic and Dielectric Relaxation Response of Unentangled UPy-Based Supramolecular Networks

    DEFF Research Database (Denmark)

    Shabbir, Aamir; Javakhishvili, Irakli; Cerveny, Silvina

    2016-01-01

    Supramolecular polymers possess versatile mechanical properties and a unique ability to respond to external stimuli. Understanding the rich dynamics of such associative polymers is essential for tailoring user-defined properties in many products. Linear copolymers of 2-methoxyethyl acrylate (MEA)...

  10. Investigation of annealing-treatment on structural and optical ...

    Indian Academy of Sciences (India)

    Administrator

    ranges are studied by X-ray diffraction (XRD) and UV-visible spectroscopic ellipsometry (SE). XRD mea- ... We found that the refractive index and the extinction coefficient increase with increas- ing annealing .... of the occurrence of light absorption resulting from the ... From the spectral relationship between extinction co-.

  11. A Novel Strategy for Carbon Capture and Sequestration by rHLPD Processing

    Energy Technology Data Exchange (ETDEWEB)

    Li, Qinghua; Gupta, Surojit; Tang, Ling; Quinn, Sean [Department of Material Science and Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ (United States); Atakan, Vahit [Solidia Technologies, Inc., Piscataway, NJ (United States); Riman, Richard E., E-mail: riman@rci.rutgers.edu [Department of Material Science and Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ (United States)

    2016-01-22

    Monoethanolamine (MEA) scrubbing is an energy-intensive process for carbon capture and sequestration (CCS) due to the regeneration of amine in stripping towers at high temperature (100–120°C) and the subsequent pressurization of CO{sub 2} for geological sequestration. In this paper, we introduce a novel method, reactive hydrothermal liquid phase densification (rHLPD), which is able to solidify (densify) monolithic materials without using high temperature kilns. Then, we integrate MEA-based CCS processing and mineral carbonation by using rHLPD technology. This integration is designated as rHLPD-carbon sequestration (rHLPD-CS) process. Our results show that the CO{sub 2} captured in the MEA-CO{sub 2} solution was sequestered by the mineral (wollastonite CaSiO{sub 3}) carbonation at a low operating temperature (60°C) and simultaneously monolithic materials with a compressive strength of ~121 MPa were formed. This suggests that the use of rHLPD-CS technology eliminates the energy consumed for CO{sub 2}-MEA stripping and CO{sub 2} compression and also sequesters CO{sub 2} to form value-added products, which have a potential to be utilized as construction and infrastructure materials. In contrast to the high energy requirements and excessive greenhouse gas emissions from conventional Portland cement manufacturing, our calculations show that the integration of rHLPD and CS technologies provides a low energy alternative to production of traditional cementitious-binding materials.

  12. Job Creation and Job Types

    DEFF Research Database (Denmark)

    Kuhn, Johan Moritz; Malchow-Møller, Nikolaj; Sørensen, Anders

    2016-01-01

    We extend earlier analyses of the job creation of start-ups versus established firms by considering the educational content of the jobs created and destroyed. We define education-specific measures of job creation and job destruction at the firm level, and we use these measures to construct a meas...

  13. Job Creation and Job Types

    DEFF Research Database (Denmark)

    Kuhn, Johan M.; Malchow-Møller, Nikolaj; Sørensen, Anders

    We extend earlier analyses of the job creation of start-ups vs. established firms by taking into consideration the educational content of the jobs created and destroyed. We define educationspecific measures of job creation and job destruction at the firm level, and we use these to construct a mea...

  14. A study of temporal effects of the model anti-androgen flutamide on components of the hypothalamic-pituitary-gonadal axis in adult fathead minnows

    Science.gov (United States)

    The aim of this study was to investigate temporal changes in the hypothalamic-pituitary-gonadal (HPG) axis of fathead minnow (Pimephales promelas) treated with the model androgen receptor (AR) antagonist, flutamide. Reproductively-mature fish were exposed in a flow-through, meas...

  15. Microelectrode Array-evaluation of Neurotoxic Effects of Magnesium as an Implantable Biomaterial.

    Science.gov (United States)

    Huang, Ting; Wang, Zhonghai; Wei, Lina; Kindy, Mark; Zheng, Yufeng; Xi, Tingfei; Gao, Bruce Z

    2016-01-01

    Magnesium (Mg)-based biomaterials have shown great potential in clinical applications. However, the cytotoxic effects of excessive Mg 2+ and the corrosion products from Mg-based biomaterials, particularly their effects on neurons, have been little studied. Although viability tests are most commonly used, a functional evaluation is critically needed. Here, both methyl thiazolyl tetrazolium (MTT) and lactate dehydrogenase (LDH) assays were used to test the effect of Mg 2+ and Mg-extract solution on neuronal viability. Microelectrode arrays (MEAs), which provide long-term, real-time recording of extracellular electrophysiological signals of in vitro neuronal networks, were used to test for toxic effects. The minimum effective concentrations (EC min ) of Mg 2+ from the MTT and LDH assays were 3 mmol/L and 100 mmol/L, respectively, while the EC min obtained from the MEA assay was 0.1 mmol/L. MEA data revealed significant loss of neuronal network activity when the culture was exposed to 25% Mg-extract solution, a concentration that did not affect neuronal viability. For evaluating the biocompatibility of Mg-based biomaterials with neurons, MEA electrophysiological testing is a more precise method than basic cell-viability testing.

  16. Paediatrics Electrocardiography

    African Journals Online (AJOL)

    Prof Ezechukwu

    2011-11-28

    Nov 28, 2011 ... Right axis deviation- Tetralogy of Fallot, pulmonary atresia, transposition of the great arteries (TGA). Superior axis deviation- Atrioventricular septal defect, tricuspid atresia. QRS Complex. The QRS complex represents ventricular depolarization and the normal duration 0.10 seconds or less. It is meas-.

  17. Joint responsibility between the EU and Member States for non-performance of obligations under multilateral environmental agreements

    NARCIS (Netherlands)

    Nollkaemper, A.; Morgera, E.

    2012-01-01

    This chapter explores the basis and manifestations of joint responsibility between the European Union (EU) and its Member States for non-performance of obligations contained in multilateral environmental agreements (MEAs). Joint responsibility has often been advanced as an attractive solution where

  18. Joint Responsibility between the EU and Member States for Non-Performance of Obligations under Multilateral Environmental Agreements

    NARCIS (Netherlands)

    Nollkaemper, A.

    2011-01-01

    This chapter explores the basis and manifestations of joint responsibility between the European Union (EU) and its Member States for non-performance of obligations contained in multilateral environmental agreements (MEAs). Joint responsibility has often been advanced as an attractive solution where

  19. Alkaline fuel cell with nitride membrane

    Science.gov (United States)

    Sun, Shen-Huei; Pilaski, Moritz; Wartmann, Jens; Letzkus, Florian; Funke, Benedikt; Dura, Georg; Heinzel, Angelika

    2017-06-01

    The aim of this work is to fabricate patterned nitride membranes with Si-MEMS-technology as a platform to build up new membrane-electrode-assemblies (MEA) for alkaline fuel cell applications. Two 6-inch wafer processes based on chemical vapor deposition (CVD) were developed for the fabrication of separated nitride membranes with a nitride thickness up to 1 μm. The mechanical stability of the perforated nitride membrane has been adjusted in both processes either by embedding of subsequent ion implantation step or by optimizing the deposition process parameters. A nearly 100% yield of separated membranes of each deposition process was achieved with layer thickness from 150 nm to 1 μm and micro-channel pattern width of 1μm at a pitch of 3 μm. The process for membrane coating with electrolyte materials could be verified to build up MEA. Uniform membrane coating with channel filling was achieved after the optimization of speed controlled dip-coating method and the selection of dimethylsulfoxide (DMSO) as electrolyte solvent. Finally, silver as conductive material was defined for printing a conductive layer onto the MEA by Ink-Technology. With the established IR-thermography setup, characterizations of MEAs in terms of catalytic conversion were performed successfully. The results of this work show promise for build up a platform on wafer-level for high throughput experiments.

  20. Humans and Their Impact on Cyber Agility

    Science.gov (United States)

    2012-06-01

    clearly). - Range of media across which these interactions occur (e.g. voice, email, video conferencing and whiteboards) - Collaborations (working...abilities that they need to accomplish the task at hand Combat Assessment Battle Damage Assessment ( BDA ) + Munitions Effectiveness Assessment (MEA), a

  1. Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes

    NARCIS (Netherlands)

    Tertoolen, L.G.J.; Braam, S. R.; van Meer, B.J.; Passier, R.; Mummery, C. L.

    2018-01-01

    Multi electrode arrays (MEAs) are increasingly used to detect external field potentials in electrically active cells. Recently, in combination with cardiomyocytes derived from human (induced) pluripotent stem cells they have started to become a preferred tool to examine newly developed drugs for

  2. Can a canopy temperature-based stress index enhance water use efficiency in irrigated wine grape under arid conditions?

    Science.gov (United States)

    Enhancement of irrigation water use efficiency and water productivity in arid wine grape production regions is hindered by a lack of automated, real-time methods for monitoring and interpreting vine water status. A normalized, water stress index calculated from real-time vine canopy temperature meas...

  3. High pressure effect on MoS2 and MoSe2 single crystals grown by ...

    Indian Academy of Sciences (India)

    Unknown

    tetrahedral anvil apparatus up to 5 GPa. In this paper we report room temperature resistance mea- surements as a function of pressure on MoS2 and MoSe2 single crystals. In each case the resistance decreases un- der pressure due to an increase in the carrier concentration. 2. Experimental. Single crystals of MoS2 and ...

  4. Accuracy of pulse oximetry in pigmented patients

    African Journals Online (AJOL)

    Trempel'" KK. Barker SJ. PuI$e Mea Gener 1966; 23: 323-327_. 21. SevennghaJJs JW, Kelleher JF. Recent developments in pulse OJlim€try. Anestilesiology 1992; 76: 1018-1038.

  5. <=ryptochromes and Biological Clocks -36 ...

    Indian Academy of Sciences (India)

    ing from cyanobacteria to humans to plants, and this high degree of ... ing them. The innate or free-running period of circardian rhythms (mea- sured in a ..... neutral radical to the catalytically competent FADH form. The enzyme then dissociates ...

  6. Transpressional granite-emplacement model: Structural and ...

    Indian Academy of Sciences (India)

    2Ministry of Water Resources and Energy, DR/C, Gas and Petroleum ... Magnetic lineation shows an 'S' shape trend that allows to (1) consider ..... j = 1–4). The magnetic susceptibility is mea- sured for different orientations of the cylindrical.

  7. Antipatharia

    African Journals Online (AJOL)

    Their stocks gradually run out, and fishermen continually search for new mea- ... gnaro were first branched corals with a bush-like shape before being cut ..... of the different arrows: 1- Black coral destination; 2- Application for license; 3- ... Gabrié, C., Vasseur, P., Randriamiarana, H., Maharavo, J. and Mara, E. 2000. The co-.

  8. Comparison CCEM-K8 of DC voltage ratio: results

    CSIR Research Space (South Africa)

    Marullo-Reedtz, G

    2003-04-01

    Full Text Available , he has been with VNIIM where he has been involved in inves- tigation and development of electrical standards of dc voltage and dc current, using quantum effects in LT- and HT-superconductors and ratio voltage mea- surement up to 1000 V. Ronald...

  9. Graphitized Carbon: A Promising Stable Cathode Catalyst Support Material for Long Term PEMFC Applications.

    Science.gov (United States)

    Mohanta, Paritosh Kumar; Regnet, Fabian; Jörissen, Ludwig

    2018-05-28

    Stability of cathode catalyst support material is one of the big challenges of polymer electrolyte membrane fuel cells (PEMFC) for long term applications. Traditional carbon black (CB) supports are not stable enough to prevent oxidation to CO₂ under fuel cell operating conditions. The feasibility of a graphitized carbon (GC) as a cathode catalyst support for low temperature PEMFC is investigated herein. GC and CB supported Pt electrocatalysts were prepared via an already developed polyol process. The physical characterization of the prepared catalysts was performed using transmission electron microscope (TEM), X-ray Powder Diffraction (XRD) and inductively coupled plasma optical emission spectrometry (ICP-OES) analysis, and their electrochemical characterizations were conducted via cyclic voltammetry(CV), rotating disk electrode (RDE) and potential cycling, and eventually, the catalysts were processed using membrane electrode assemblies (MEA) for single cell performance tests. Electrochemical impedance spectroscopy (EIS) and scanning electrochemical microscopy (SEM) have been used as MEA diagonostic tools. GC showed superior stability over CB in acid electrolyte under potential conditions. Single cell MEA performance of the GC-supported catalyst is comparable with the CB-supported catalyst. A correlation of MEA performance of the supported catalysts of different Brunauer⁻Emmett⁻Teller (BET) surface areas with the ionomer content was also established. GC was identified as a promising candidate for catalyst support in terms of both of the stability and the performance of fuel cell.

  10. An investigation into modulators

    International Nuclear Information System (INIS)

    Heine, E.

    1988-01-01

    In the framework of the MEA-update it is important to establish which modulators are necessary. In this report it is lookedif the existing modulators can be maintained or new modulators have to be made. Besides technical aspects also material expenses and necessary manpower play a role. 12 figs.; 6 tabs

  11. A Framework for the Comparative Assessment of Neuronal Spike Sorting Algorithms towards More Accurate Off-Line and On-Line Microelectrode Arrays Data Analysis.

    Science.gov (United States)

    Regalia, Giulia; Coelli, Stefania; Biffi, Emilia; Ferrigno, Giancarlo; Pedrocchi, Alessandra

    2016-01-01

    Neuronal spike sorting algorithms are designed to retrieve neuronal network activity on a single-cell level from extracellular multiunit recordings with Microelectrode Arrays (MEAs). In typical analysis of MEA data, one spike sorting algorithm is applied indiscriminately to all electrode signals. However, this approach neglects the dependency of algorithms' performances on the neuronal signals properties at each channel, which require data-centric methods. Moreover, sorting is commonly performed off-line, which is time and memory consuming and prevents researchers from having an immediate glance at ongoing experiments. The aim of this work is to provide a versatile framework to support the evaluation and comparison of different spike classification algorithms suitable for both off-line and on-line analysis. We incorporated different spike sorting "building blocks" into a Matlab-based software, including 4 feature extraction methods, 3 feature clustering methods, and 1 template matching classifier. The framework was validated by applying different algorithms on simulated and real signals from neuronal cultures coupled to MEAs. Moreover, the system has been proven effective in running on-line analysis on a standard desktop computer, after the selection of the most suitable sorting methods. This work provides a useful and versatile instrument for a supported comparison of different options for spike sorting towards more accurate off-line and on-line MEA data analysis.

  12. Solar fuel production in a novel polymeric electrolyte membrane photoelectrochemical (PEM-PEC) cell with a web of titania nanotube arrays as photoanode and gaseous reactants

    NARCIS (Netherlands)

    Stoll, T.; Zafeiropoulos, G.; Tsampas, M. N.

    2016-01-01

    A novel photoelectrochemical (PEC) cell design is proposed and investigated for H-2 production with gaseous reactants. The core of the cell is a membrane electrode assembly (MEA) that consists of a TiO2 nanotube arrays photoanode, a Pt/C cathode, a Pt/C reference electrode and a proton conducting

  13. Effect of pKa on the kinetics of carbon dioxide absorption in aqueous alkanolamine solutions containing carbonic anhydrase at 298K

    NARCIS (Netherlands)

    Penders-van Elk, Nathalie J M C; Fradette, Sylvie; Versteeg, Geert F.

    2015-01-01

    The absorption of carbon dioxide in various aqueous alkanolamine solutions have been studied with and without carbonic anhydrase respectively in a stirred cell reactor at 298K. The examined alkanolamines were: N,N-diethylethanolamine (DEMEA), N,N-dimethylethanolamine (DMMEA), monoethanolamine (MEA),

  14. Is macroeconomic announcement news priced?

    NARCIS (Netherlands)

    de Goeij, Peter; Hu, Jiehui; Werker, Bas

    2016-01-01

    We test whether news contained in macroeconomic announcements (MEAs) is priced in the cross-section of stock returns. When including news on a set of widely followed individual macroeconomic fundamentals in the cross-section of stock returns, estimates of their prices of risk are consistent with the

  15. High Pt utilization PEMFC electrode obtained by alternative ion-exchange/electrodeposition.

    Science.gov (United States)

    Chen, Siguo; Wei, Zidong; Li, Hua; Li, Li

    2010-12-14

    High Pt utilization PEMFC electrodes were prepared by an alternative ion-exchange/electrodeposition (AIEE) technique. The results demonstrated that the MEA employing an AIEE electrode with a Pt loading of 0.014 mg Pt cm(-2) exhibits performance approximately 2.2 times larger than that employing a conventional Nafion-bonded Pt/C electrode with a same Pt loading.

  16. Low stoichiometry operation of a polymer electrolyte membrane fuel cell employing the interdigitated flow field design

    DEFF Research Database (Denmark)

    Berning, Torsten; Odgaard, Madeleine; Kær, Søren Knudsen

    2011-01-01

    Fuel cell operation on dry reactant gases under low stoichiometry conditions employing the interdigitated flow field is investigated using a multi-fluid model. It is assumed that the MEA contains a water uptake layer which facilitates water absorption to the membrane and hence prevents the anode...

  17. A Novel Strategy of Carbon Capture and Sequestration by rHLPD Processing

    Directory of Open Access Journals (Sweden)

    Richard Eric Riman

    2016-01-01

    Full Text Available Monoethanolamine (MEA scrubbing is an energy intensive process for Carbon Capture and Sequestration (CCS due to the regeneration of amine in stripping towers at high temperature (100-120 ºC and the subsequent pressurization of CO2 for geologic sequestration. In this paper, we introduce a novel method, reactive hydrothermal liquid phase densification (rHLPD, which is able to solidify (densify monolithic materials without using high temperature kilns. Then we integrate MEA-based CCS processing and mineral carbonation by using rHLPD technology. This integration is designated as rHLPD-Carbon Sequestration (rHLPD-CS process. Our results show that the CO2 captured in the MEA-CO2 solution was sequestered by the mineral (wollastonite CaSiO3 carbonation at a low operating temperature (60 ºC and simultaneously monolithic materials with a compressive strength of ~121 MPa were formed. This suggests that the use of rHLPD-CS technology eliminates the energy consumed for CO2-MEA stripping and CO2 compression and also sequesters CO2 to form value-added products, which have a potential to be utilized as construction and infrastructure materials. In contrast to the high energy requirements and excessive greenhouse gas emissions from conventional Portland cement manufacturing, our calculations show that the integration of rHLPD and CS technologies provides a low energy alternative to production of traditional cementitious binding materials.

  18. Functional connectivity metrics during stroke recovery

    DEFF Research Database (Denmark)

    Yourganov, Grigori; Schmah, Tanya; Small, Steven L.

    2010-01-01

    We explore functional connectivity in nine subjects measured with 1 5T fMRI-BOLD in a longitudinal study of recovery from unilateral stroke affecting the motor area (Small et al, 2002) We found that several measures of complexity of covariance matrices show strong correlations with behavioral mea...

  19. Near-Road Modeling and Measurement of Particles Generated by Nanoparticle Diesel Fuel Additive Use

    Science.gov (United States)

    Cerium oxide (ceria) nanoparticles (n-Ce) are used as a fuel-borne catalyst in diesel engines to reduce particulate emissions, yet the environmental and human health impacts of the ceria-doped diesel exhaust aerosols are not well understood. To bridge the gap between emission mea...

  20. Detector response calculated with libamtrack compared with data for different solid state detectors

    DEFF Research Database (Denmark)

    Herrmann, Rochus; Greilich, Steffen; Grzanka, Leszek

    . Greilich et al. “Amorphous track models: A numerical comparison study”, Radiat. Meas., in press; doi:10.1016/j.radmeas.2010.05.039 [3] Palmans H. “Effect of alanine energy response and phantom materials on depth dose measurements in ocular proton beams.”, Technol Cancer Res Treat.;2:6;579-86;(2003) [4...

  1. A microelectrode array electrodeposited with reduced graphene oxide and Pt nanoparticles for norepinephrine and electrophysiological recordings

    Science.gov (United States)

    Wang, Li; Song, Yilin; Zhang, Yu; Xu, Shengwei; Xu, Huiren; Wang, Mixia; Wang, Yang; Cai, Xinxia

    2017-11-01

    Norepinephrine (NE), a common neurotransmitter released by locus coeruleus neurons, plays an essential role in the communication mechanism of the mammalian nervous system. In this work, a microelectrode array (MEA) was fabricated by micro-electromechanical system (MEMS) technology to provide a rapid, sensitive and reliable method for the direct determination in NE dynamic secretion. To improve the electrical performance, the MEA was electrodeposited with the reduced graphene oxide and Pt nanoparticles (rGOPNps). rGOPNps-MEA was investigated using scanning electron microscopy, atomic force microscopy and electrochemical impedance spectroscopy, differential pulse voltammetry exhibited remarkably electrocatalytic properties towards NE. Calibration results showed a sensitivity of 1.03 nA µM-1 to NE with a detection limit of 0.08 µM. In Particular, the MEA was successfully used for measuring dynamic extracellular NE secretion from the locus coeruleus brain slice, as well as monitoring spike firing from the hippocampal brain slice. This fabricated device has potential in studies of spatially resolved delivery of trace neurochemicals and electrophysiological activities of a variety of biological tissues in vitro.

  2. Prompt radiation detectors to monitor target conditions

    DEFF Research Database (Denmark)

    Barnhart, T. E.; Engle, J. W.; Valdovinos, H. F.

    2012-01-01

    Lessons learned by basic scientists in the study of experimental nuclear physics can often go unnoticed by cyclotron operator’s intent on meeting a demanding schedule of tracer production. Prompt neutrons and gammas are the signature that the desired reaction is occurring, providing a robust meas...

  3. 78 FR 68699 - IFR Altitudes; Miscellaneous Amendments

    Science.gov (United States)

    2013-11-15

    ... MAROC, IL FIX *3000 *2400--MOCA MAROC, IL FIX PONTIAC, IL VOR/DME..... 2500 Sec. 95.6066 VOR Federal..., IL VORTAC MAROC, IL FIX *3000 *2400--MOCA MAROC, IL FIX PONTIAC, IL VOR/DME..... 2500 From To MEA MAA...

  4. A nutrient’s downstream spiral

    Science.gov (United States)

    Indicators of a stream’s ability to remove nutrients provide insights on watershed integrity and stream habitat characteristics that are needed to help managers to restore stream ecosystem services. We used the Tracer Additon Spiraling Characterization Curve (TASCC) to mea...

  5. Landfill gas (LFG) processing via adsorption and alkanolamine absorption

    Energy Technology Data Exchange (ETDEWEB)

    Gaur, Ankur; Park, Jin-Won; Song, Ho-Jun; Park, Jong-Jin [Department of Chemical and Biomolecular Engineering, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-749 (Korea); Maken, Sanjeev [Department of Chemistry, Deenbandhu Chhotu Ram University of Science and Technology, Murthal-131 039, Haryana (India)

    2010-06-15

    Landfill gas (LFG) was upgraded to pure methane using the adsorption and absorption processes. Different toxic compounds like aromatics and chlorinated compounds were removed using granular activated carbon. The activated carbon adsorbed toxic trace components in the following order: carbon tetrachloride > toluene > chloroform > xylene > ethylbenzene > benzene > trichloroethylene {approx} tetrachloroethylene. After removing all trace components, the gas was fed to absorption apparatus for the removal of carbon dioxide (CO{sub 2}). Two alkanolamines, monoethanol amine (MEA) and diethanol amine (DEA) were used for the removal of CO{sub 2} from LFG. The maximum CO{sub 2} loading is obtained for 30 wt.% MEA which is around 2.9 mol L{sup -} {sup 1} of absorbent solution whereas for same concentration of DEA it is around 1.66 mol L {sup -} {sup 1} of solution. 30 wt% MEA displayed a higher absorption rate of around 6.64 x 10{sup -} {sup 5} mol L{sup -} {sup 1} min{sup -} {sup 1}. DEA displayed a higher desorption rate and a better cyclic capacity as compared to MEA. Methane obtained from this process can be further used in the natural gas network for city. (author)

  6. SPECIES DISTRIBUTIONS, SURROGACY, AND IMPORTANT CONSERVATION REGIONS IN CANADA

    Science.gov (United States)

    Conservation actions could be more efficient if there is congruence among taxa in the distribution of species. Patterns in the geographic distribution of species of six taxa were used to identify nationally important sites for conservation in Canada. Species richness and a meas...

  7. Nitrogen deposition and terrestrial biodiversity

    Science.gov (United States)

    Christopher M. Clark; Yongfei Bai; William D. Bowman; Jane M. Cowles; Mark E. Fenn; Frank S. Gilliam; Gareth K. Phoenix; Ilyas Siddique; Carly J. Stevens; Harald U. Sverdrup; Heather L. Throop

    2013-01-01

    Nitrogen deposition, along with habitat losses and climate change, has been identified as a primary threat to biodiversity worldwide (Butchart et al., 2010; MEA, 2005; Sala et al., 2000). The source of this stressor to natural systems is generally twofold: burning of fossil fuels and the use of fertilizers in modern intensive agriculture. Each of these human...

  8. Long-Term Durability of PBI-Based HT-PEM Fuel Cells: Effect of Operating Parameters

    DEFF Research Database (Denmark)

    Søndergaard, Tonny; Cleemann, Lars Nilausen; Becker, Hans

    2018-01-01

    -term operation. Durability is assessed for 16 identically fabricated membrane electrode assemblies (MEAs), and evaluations are carried out using operating parameters as stressors with gas stoichiometries ranging from 2 to 25, current densities from 200 to 800 mA cm(-2), and temperatures of 160 or 180 degrees C...

  9. HPLC quantification of phenolic content and assessment of ...

    African Journals Online (AJOL)

    The study was aimed at evaluating the toxicological and antioxidant activities of Antiaris africana Engl. (family Moraceae), that is used in Nigeria and other West Africa countries as a panacea for the treatment of several ailments. The methanolic extract of A. africana (MEA) obtained was analysed for antioxidant activities in ...

  10. European Scientific Notes. Volume 34, Number 11,

    Science.gov (United States)

    1980-11-30

    optic com- are also studying the acoustics of musical munication systems operations. Their instruments (especially violins and approach to picture coding...for meas- used for examing internal structure of uring tension. the eye, which is now being manufactured at the Finnish company, Lasertek. In opera

  11. Thyroid stimulating immunoglobulins in Graves' disease with goitre growth, low thyroxine and increasing triiodothyronine during PTU treatment

    DEFF Research Database (Denmark)

    Hegedüs, Laszlo; Hansen, J M; Bech, K

    1984-01-01

    In 50 consecutive patients with Graves' disease treated with PTU, 7 (group 1) developed increasing goitre in spite of unmeasurable TSH. Thyroid variables were compared with those from 10 controls with an ordinary response to PTU (group 2). Serum T4 decreased in group 1 from 246 +/- 47 nmol/l (mea...

  12. In-situ Calibration of Ground -based Lidar instrument

    DEFF Research Database (Denmark)

    Georgieva Yankova, Ginka; Villanueva, Héctor

    This report presents the result of the lidar in-situ calibration performed at DTU’s test site for large wind turbine at Østerild, Denmark. Calibration is here understood as the establishment of a relation between the reference wind speed measurements with measurement uncertainties provided by mea...

  13. Browse Title Index

    African Journals Online (AJOL)

    Items 201 - 250 of 1309 ... Mea van Huyssteen, Pieter J Milne, Eileen E Campbell, Maryna van de Venter. Vol 3, No 1 (2006) ... SR Fahmy, AM Soliman, EM Ali. Vol 12, No 4 (2015) ... M Rahmatullah, M Hossain, A Mahmud, N Sultana, S Mizanur, R Mohammad, R Islam, MS Khatoon, S Jahan, F Islam. Vol 10, No 5 (2013) ...

  14. ХL

    Indian Academy of Sciences (India)

    time-reversal invariance. A Euclidean space-time version of this invariance also exists. This is necessary in setting up the Euclidean functional integral. A mea- sure for quark functional integration can be constructed to be invariant under this. Euclidean transformation in addition to strong and electromagnetic gauge transfor-.

  15. Methyltrioctylammonium chloride catalysed sonochemical synthesis ...

    Indian Academy of Sciences (India)

    an important and principal task in organic chemistry. A straightforward method for the synthesis of these compounds involve a condensation between aldehydes, ... All melting points were recorded in open capillary mea- surements, using sulphuric acid bath and are uncor- rected. IR spectra were recorded as KBr pellets on ...

  16. Musical Electroacupuncture May Be a Better Choice than Electroacupuncture in a Mouse Model of Alzheimer’s Disease

    Directory of Open Access Journals (Sweden)

    Jing Jiang

    2016-01-01

    Full Text Available Objectives. To compare musical electroacupuncture and electroacupuncture in a mouse model of Alzheimer’s disease. Methods. In this study, 7.5-month-old male senescence-accelerated mouse prone 8 (SAMP8 mice were used as an Alzheimer’s disease animal model. In the normal control paradigm, 7.5-month-old male SAMR1 mice were used as the blank control group (N group. After 15 days of treatment, using Morris water maze test, micro-PET, and immunohistochemistry, the differences among the musical electroacupuncture (MEA, electroacupuncture (EA, Alzheimer’s disease (AD, and normal (N groups were assessed. Results. The Morris water maze test, micro-PET, and immunohistochemistry revealed that MEA and EA therapies could improve spatial learning and memory ability, glucose metabolism level in the brain, and Aβ amyloid content in the frontal lobe, compared with the AD group (P<0.05. Moreover, MEA therapy performed better than EA treatment in decreasing amyloid-beta levels in the frontal lobe of mice with AD. Conclusion. MEA therapy may be superior to EA in treating Alzheimer’s disease as demonstrated in SAMP8 mice.

  17. Vision-GPS Fusion for Guidance of an Autonomous Vehicle in Row Crops

    DEFF Research Database (Denmark)

    Bak, Thomas

    2001-01-01

    This paper presents a real-time localization system for an autonomous vehicle passing through 0.25 m wide crop rows at 6 km/h. Localization is achieved by fusion of mea-surements from a row guidance sensor and a GPS receiver. Conventional agricultural practice applies inputs such as herbicide...

  18. Improving Impedance of Implantable Microwire Multi-Electrode Arrays by Ultrasonic Electroplating of Durable Platinum Black

    Science.gov (United States)

    Desai, Sharanya Arcot; Rolston, John D.; Guo, Liang; Potter, Steve M.

    2010-01-01

    Implantable microelectrode arrays (MEAs) have been a boon for neural stimulation and recording experiments. Commercially available MEAs have high impedances, due to their low surface area and small tip diameters, which are suitable for recording single unit activity. Lowering the electrode impedance, but preserving the small diameter, would provide a number of advantages, including reduced stimulation voltages, reduced stimulation artifacts and improved signal-to-noise ratio. Impedance reductions can be achieved by electroplating the MEAs with platinum (Pt) black, which increases the surface area but has little effect on the physical extent of the electrodes. However, because of the low durability of Pt black plating, this method has not been popular for chronic use. Sonicoplating (i.e. electroplating under ultrasonic agitation) has been shown to improve the durability of Pt black on the base metals of macro-electrodes used for cyclic voltammetry. This method has not previously been characterized for MEAs used in chronic neural implants. We show here that sonicoplating can lower the impedances of microwire multi-electrode arrays (MMEA) by an order of magnitude or more (depending on the time and voltage of electroplating), with better durability compared to pulsed plating or traditional DC methods. We also show the improved stimulation and recording performance that can be achieved in an in vivo implantation study with the sonicoplated low-impedance MMEAs, compared to high-impedance unplated electrodes. PMID:20485478

  19. Factors influencing the oxidation of cysteamine and other thiols: implications for hyperthermic sensitization and radiation protection

    International Nuclear Information System (INIS)

    Biaglow, J.E.; Issels, R.W.; Gerweck, L.E.; Varnes, M.E.; Jacobson, B.; Mittchell, J.B.; Russo, A.

    1984-01-01

    Some of the factors influencing the oxygen uptake and peroxide formation for cysteamine (MEA) and other thiols in serum-supplemented modified McCoy's 5A, a well-known medium used to cultivate a variety of cells in vitro, have been studied. The oxidation of MEA and cysteine in modified McCoy's 5A has been compared with that in Ham's F-12, MEM, and phosphate-buffered saline. The ability to produce peroxide is dependent upon the temperature, the concentration of thiol, the presence of copper ions, and pH of the medium. Catalase also reduces the oxygen uptake for all thiols. Superoxide dismutase (SOD) was found to stimulate the oxygen uptake in the case of MEA and cysteine, but had little or no effect with DTT and glutathione. The combined presence of SOD and catalase resulted in less inhibition of oxygen uptake than that obtained by catalase alone. Alkaline pH was found to enhance the oxidation of cysteine and MEA. The results indicate that many problems may arise when thiols are added to various media. A major consideration is concerned with the production of peroxide, superoxide, and reduced trace metal intermediates. The presence of these intermediates may result in the production of hydroxyl radical intermediates as well as the eventual oxygen depletion from the medium

  20. 76 FR 11675 - IFR Altitudes; Miscellaneous Amendments

    Science.gov (United States)

    2011-03-03

    ... action is needed because of changes occurring in the National Airspace System. These changes are designed... matters of flight safety and operational efficiency in the National Airspace System, are related to... RIVER, AK NDB BARTER ISLAND, AK NDB... 2000 From To MEA MAA Sec. 95.3000 Low Altitude RNAV Routes Sec...

  1. Discussion: “Model reduction of large-scale discrete plants with specified frequency-domain balanced structure”

    DEFF Research Database (Denmark)

    Shaker, Hamid Reza; Wisniewski, Rafal

    2009-01-01

    This work presents a commentary of the article published by A. Zadegan and A. Zilouchian (2005, ASME J. Dyn. Syst. Meas., Control, 127, pp. 486-498). We show their order reduction method is not always true and may lead to inaccurate results and is therefore erroneous. A framework for solving the ...

  2. Researches on Preliminary Chemical Reactions in Spark-Ignition Engines

    Science.gov (United States)

    1943-06-01

    compression type, without ignition, the resulting preliminary reactions being detectable and meas- urable thermometrically . Contents I. Influence of Preliminary...thoroughly insulated be- tween the carburettor and the engine, by aluminium foil and asbestos. -I -I " I" I ’I il i~ " !, I I 1𔃻I I’ ) To enable the

  3. Estimating evapotranspiration using remote sensing and the Surface ...

    African Journals Online (AJOL)

    2013-07-08

    Jul 8, 2013 ... In this paper the application of energy balance methods in South Africa is reviewed ..... boundary layer (Van der Kwast et al., 2009). It is therefore clear ..... JARMAIN C (2004) Theory and practice of evaporation meas- urement ...

  4. System effects influencing the bending strength of timber beams

    DEFF Research Database (Denmark)

    Ditlevsen, Ove Dalager; Källsner, B.

    1998-01-01

    A stochastic model of hierarchical series system type for the bending strength of spruce beams isdefined from the anticipation that the bending failure takes place at a cross-section with a defect cluster formed by knots or grain irregularities. The parameters of the model are estimated from meas...

  5. Social Isolation During Postweaning Development Causes Hypoactivity of Neurons in the Medial Nucleus of the Male Rat Amygdala

    Science.gov (United States)

    Adams, Thomas; Rosenkranz, J Amiel

    2016-01-01

    Children exposed to neglect or social deprivation are at heightened risk for psychiatric disorders and abnormal social patterns as adults. There is also evidence that prepubertal neglect in children causes abnormal metabolic activity in several brain regions, including the amygdala area. The medial nucleus of the amygdala (MeA) is a key region for performance of social behaviors and still undergoes maturation during the periadolescent period. As such, the normal development of this region may be disrupted by social deprivation. In rodents, postweaning social isolation causes a range of deficits in sexual and agonistic behaviors that normally rely on the posterior MeA (MeAp). However, little is known about the effects of social isolation on the function of MeA neurons. In this study, we tested whether postweaning social isolation caused abnormal activity of MeA neurons. We found that postweaning social isolation caused a decrease of in vivo firing activity of MeAp neurons, and reduced drive from excitatory afferents. In vitro electrophysiological studies found that postweaning social isolation caused a presynaptic impairment of excitatory input to the dorsal MeAp, but a progressive postsynaptic reduction of membrane excitability in the ventral MeAp. These results demonstrate discrete, subnucleus-specific effects of social deprivation on the physiology of MeAp neurons. This pathophysiology may contribute to the disruption of social behavior after developmental social deprivation, and may be a novel target to facilitate the treatment of social disorders. PMID:26677945

  6. Fulltext PDF

    Indian Academy of Sciences (India)

    CERN SPS neutral kaon beams, on the direct CP violation parameter Re(ε. ' /ε), as mea- sured from the decay rates of neutral kaons into two pions. The data ..... really useful for even tual improvemen t of the. CKM matrix parameter η b ecause.

  7. Ammonium ion transport by the AMT/Rh homolog TaAMT1;1 is stimulated by acidic pH

    DEFF Research Database (Denmark)

    Søgaard, Rikke; Alsterfjord, Magnus; Macaulay, Nanna

    2009-01-01

    It is unclear how ammonia is transported by proteins from the Amt/Mep/Rh superfamily. We investigated this for the ammonium transporter TaAMT1;1 from wheat expressed in Xenopus oocytes by two-electrode voltage clamp and radio-labeled uptakes. Inward currents were activated by NH (4......) (+) or methylammonium ions (MeA(+)). Importantly, currents increased fivefold when the external pH was decreased from 7.4 to 5.5; this type of pH dependence is unique and is a strong indication of NH (4) (+) or MeA(+) transport. This was confirmed by the close correlation between the uptake of radio-labeled Me......A(+) and MeA(+)-induced currents. Homology models of members of the Amt/Mep/Rh superfamily exhibited major divergences in their cytoplasmic regions. A point mutation in this region of TaAMT1;1 abolished the pH sensitivity and decreased the apparent affinities for NH (4) (+) and MeA(+). We suggest a model...

  8. Microscopic insight in the study of yrast bands in selenium isotopes

    Indian Academy of Sciences (India)

    the rotational-like energy spacings of the yrast states with I≥6. ... even–even selenium isotopes, the study of structure of high spin states through mea- ... calculations with this model can achieve a comparable quality to the large-scale ... model in that the PSM uses the angular momentum projected states as the basis.

  9. An Integrated Knowledge Based Engineering Mechatronics Modeling Approach to Support the Design of Unstable and Unmanned Aircraft

    NARCIS (Netherlands)

    Tian, F.N.

    2015-01-01

    The commercial transport aircraft industry is currently developing new “more electric aircraft” (MEA) designs in which various conventional mechanical, hydraulic and pneumatic power systems are replaced with electrically-based power systems. Their objective is to improve the overall flight

  10. Estrogen receptor-a in medial amygdala neurons regulates body weight

    Science.gov (United States)

    Estrogen receptor–a (ERa) activity in the brain prevents obesity in both males and females. However, the ERa-expressing neural populations that regulate body weight remain to be fully elucidated. Here we showed that single-minded–1 (SIM1) neurons in the medial amygdala (MeA) express abundant levels ...

  11. Synthesis and structural studies of Na2 O–ZnO–ZnF2 –B2 O3 ...

    Indian Academy of Sciences (India)

    Wintec

    differential scanning calorimeter (Modulated DSC 2820) with small pieces of the samples in the temperature range. 95–550°C. The density of the glass samples were mea- sured by Archimedes principle using benzene as an im- mersion liquid (density, ρ = 0⋅879 g/cc). 3. Results and discussion. 3.1 Density. Figure 1 shows ...

  12. Correction of aggregative thrombocytes activity in patients with unstable angina by THz irradiation of nitrogen oxide occurrence at in vitro conditions

    Directory of Open Access Journals (Sweden)

    Vyacheslav F. Kirichuk

    2013-11-01

    Full Text Available There had been shown a normalizing effect of THz radiation of MEAS (molecular emission and absorption spectrum of 400 GHz nitrogen oxide occurrence on aggregation parameters of thrombocytes in patients with unstable angina at in vitro conditions. 180 patients with an unstable angina had been involved in to the research.

  13. Highly scalable parallel processing of extracellular recordings of Multielectrode Arrays.

    Science.gov (United States)

    Gehring, Tiago V; Vasilaki, Eleni; Giugliano, Michele

    2015-01-01

    Technological advances of Multielectrode Arrays (MEAs) used for multisite, parallel electrophysiological recordings, lead to an ever increasing amount of raw data being generated. Arrays with hundreds up to a few thousands of electrodes are slowly seeing widespread use and the expectation is that more sophisticated arrays will become available in the near future. In order to process the large data volumes resulting from MEA recordings there is a pressing need for new software tools able to process many data channels in parallel. Here we present a new tool for processing MEA data recordings that makes use of new programming paradigms and recent technology developments to unleash the power of modern highly parallel hardware, such as multi-core CPUs with vector instruction sets or GPGPUs. Our tool builds on and complements existing MEA data analysis packages. It shows high scalability and can be used to speed up some performance critical pre-processing steps such as data filtering and spike detection, helping to make the analysis of larger data sets tractable.

  14. Synthesis, Characterization and Bulk Properties of Amphiphilic Copolymers Containing Fluorinated Methacrylates from Sequential Copper-Mediated Radical Polymerization

    DEFF Research Database (Denmark)

    Hansen, Natanya Majbritt Louie; Gerstenberg, Michael; Haddleton, David M.

    2008-01-01

    acrylate (MEA), and poly(ethylene glycol) methyl ether methacrylate (PEGMA) by Atom Transfer Radical Polymerization. A kinetic study of the 3FM homopolymerization initiated with ethyl bromoisobutyrate and Cu(I)Br/N-(n-propyl)-2-pyridylmethanimine reveals a living/ controlled polymerization in the range 80...

  15. Investigation of Ruthenium Dissolution in Advanced Membrane Electrode Assemblies for Direct Methanol Based Fuel Cell Stacks

    Science.gov (United States)

    Valdez, Thomas I.; Firdosy, S.; Koel, B. E.; Narayanan, S. R.

    2005-01-01

    Dissolution of ruthenium was observed in the 80-cell stack. Duration testing was performed in single cell MEAs to determine the pathway of cell degradation. EDAX analysis on each of the single cell MEAs has shown that the Johnson Matthey commercial catalyst is stable in DMFC operation for 250 hours, no ruthenium dissolution was observed. Changes in the hydrophobicity of the cathode backing papers was minimum. Electrode polarization analysis revealed that the MEA performance loss is attributed to changes in the cathode catalyst layer. Ruthenium migration does not seem to occur during cell operation but can occur when methanol is absent from the anode compartment, the cathode compartment has access to air, and the cells in the stack are electrically connected to a load (Shunt Currents). The open-to-air cathode stack design allowed for: a) The MEAs to have continual access to oxygen; and b) The stack to sustain shunt currents. Ruthenium dissolution in a DMFC stack can be prevented by: a) Developing an internally manifolded stacks that seal reactant compartments when not in operation; b) Bringing the cell voltages to zero quickly when not in operation; and c) Limiting the total number of cells to 25 in an effort to limit shunt currents.

  16. Highly Durable Direct Methanol Fuel Cell with Double-Layered Catalyst Cathode

    Directory of Open Access Journals (Sweden)

    Jing Liu

    2015-01-01

    Full Text Available Polymer electrolyte membrane (PEM is one of the key components in direct methanol fuel cells. However, the PEM usually gets attacked by reactive oxygen species during the operation period, resulting in the loss of membrane integrity and formation of defects. Herein, a double-layered catalyst cathode electrode consisting of Pt/CeO2-C as inner catalyst and Pt/C as outer catalyst is fabricated to extend the lifetime and minimize the performance loss of DMFC. Although the maximum power density of membrane electrode assembly (MEA with catalyst cathode is slightly lower than that of the traditional one, its durability is significantly improved. No obvious degradation is evident in the MEA with double-layered catalyst cathode within durability testing. These results indicated that Pt/CeO2-C as inner cathode catalyst layer greatly improved the stability of MEA. The significant reason for the improved stability of MEA is the ability of CeO2 to act as free-radical scavengers.

  17. Investigation of Ruthenium Dissolution in Advanced Membrane Electrode Assemblies for Direct Methanol Based Fuel Cells Stacks

    Science.gov (United States)

    Valdez, T. I.; Firdosy, S.; Koel, B. E.; Narayanan, S. R.

    2005-01-01

    This viewgraph presentation gives a detailed review of the Direct Methanol Based Fuel Cell (DMFC) stack and investigates the Ruthenium that was found at the exit of the stack. The topics include: 1) Motivation; 2) Pathways for Cell Degradation; 3) Cell Duration Testing; 4) Duration Testing, MEA Analysis; and 5) Stack Degradation Analysis.

  18. Further Evaluation of DNT Hazard Screening using Neural Networks from Rat Cortical Neurons on Multi-well Microelectrode Arrays

    Science.gov (United States)

    Thousands of chemicals have not been characterized for their DNT potential. Due to the need for DNT hazard identification, efforts to develop screening assays for DNT potential is a high priority. Multi-well microelectrode arrays (MEA) measure the spontaneous activity of electr...

  19. Coupling landscape water storage and supplemental irrigation to increase productivity and improve environmental stewardship in the US Midwest

    Science.gov (United States)

    Agriculture must expand production for a growing population while simultaneously reducing its environmental impacts. These goals need not be in tension with one another. Here we outline a vision for improving both the productivity and environmental performance of agriculture in the US Corn Belt. Mea...

  20. Aspergillus flavus Blast2GO gene ontology database: elevated growth temperature alters amino acid metabolism

    Science.gov (United States)

    The availability of a representative gene ontology (GO) database is a prerequisite for a successful functional genomics study. Using online Blast2GO resources we constructed a GO database of Aspergillus flavus. Of the predicted total 13,485 A. flavus genes 8,987 were annotated with GO terms. The mea...

  1. Methods for Cavitation Prediction on Tip-Modified Propellers in Ship Wake Fields

    DEFF Research Database (Denmark)

    Shin, Keun Woo; Regener, Pelle Bo; Andersen, Poul

    2015-01-01

    Unsteady cavitation simulations on a tip-modified propellerin behind-hull condition are made by both BoundaryElement Method (BEM) and Computational FluidDynamics (CFD).As the hull geometry typically is not disclosed to thepropeller designer and thus cannot be included in thesimulation, other meas...

  2. Competent Counseling for Middle Eastern American Clients: Implications for Trainees

    Science.gov (United States)

    Soheilian, Sepideh S.; Inman, Arpana G.

    2015-01-01

    The authors used a factorial multivariate analysis of variance (MANOVA) to determine whether counselor trainees' group differences on measures of multicultural competence, empathy, and multicultural counseling self-efficacy (CSE) when working with Middle Eastern American (MEA) clients were moderated by trainee race. Two hundred and fifty-six…

  3. Wearable Multi-Channel Microelectrode Membranes for Elucidating Electrophysiological Phenotypes of Injured Myocardium

    Science.gov (United States)

    Cao, Hung; Yu, Fei; Zhao, Yu; Zhang, Xiaoxiao; Tai, Joyce; Lee, Juhyun; Darehzereshki, Ali; Bersohn, Malcolm; Lien, Ching-Ling; Chi, Neil C.; Tai, Yu-Chong; Hsiai, Tzung K.

    2014-01-01

    Understanding the regenerative capacity of small vertebrate models has provided new insights into the plasticity of injured myocardium. Here, we demonstrated the application of flexible microelectrode arrays (MEAs) in elucidating electrophysiological phenotypes of zebrafish and neonatal mouse models of heart regeneration. The 4-electrode MEA membranes were designed to detect electrical signals in the aquatic environment. They were micro-fabricated to adhere to the non-planar body surface of zebrafish and neonatal mice. The acquired signals were processed to display electrocardiogram (ECG) with high signal-to-noise-ratios, and were validated via the use of conventional micro-needle electrodes. The 4-channel MEA provided signal stability and spatial resolution, revealing the site-specific electrical injury currents such as ST-depression in response to ventricular cryo-injury. Thus, our polymer-based and wearable MEA membranes provided electrophysiological insights in long-term conduction phenotypes for small vertebral models of heart injury and regeneration with a translational implication for monitoring cardiac patients. PMID:24945366

  4. ROBUST ESTIMATION OF MEAN AND VARIANCE USING ENVIRONMENTAL DATA SETS WITH BELOW DETECTION LIMIT OBSERVATIONS

    Science.gov (United States)

    Scientists, especially environmental scientists often encounter trace level concentrations that are typically reported as less than a certain limit of detection, L. Type 1, left-censored data arise when certain low values lying below L are ignored or unknown as they cannot be mea...

  5. Vitamin D insufficiency, preterm delivery and preeclampsia in women with type 1 diabetes - an observational study

    DEFF Research Database (Denmark)

    Vestgaard, Marianne; Secher, Anna L; Ringholm, Lene

    2017-01-01

    INTRODUCTION: The aim of this study was to evaluate whether vitamin D insufficiency is associated with preterm delivery and preeclampsia in women with type 1 diabetes. MATERIAL AND METHODS: An observational study of 198 pregnant women with type 1 diabetes. 25-Hydroxy-Vitamin D and HbA1c were meas...

  6. Optimisation of lean vapour compression (LVC) as an option for post-combustion CO2 capture: net present value maximisation

    NARCIS (Netherlands)

    Sanchez Fernandez, E.; Bergsma, E.J.; Miguel Mercader, F. de; Goetheer, E.L.V.; Vlugt, T.J.H.

    2012-01-01

    Many process schemes have been proposed in literature to decrease the energy demand of amine based carbon dioxide processes. These process schemes are generally analysed in terms of energy demand savings and compared to a common baseline based on the solvent monoethanolamine (MEA). In this work, the

  7. Generalized Grüneisen parameters and low temperature limit of ...

    Indian Academy of Sciences (India)

    The low temperature limit of volume thermal expansion calculated here for cad- mium and zirconium is found to be positive and so we expect a positive volume expansion down to 0 K even though the mode gammas are negative. The mea- surement of higher-order elastic constants and hence the calculation of the thermal.

  8. 77 FR 38477 - IFR Altitudes; Miscellaneous Amendments

    Science.gov (United States)

    2012-06-28

    ... MEA Sec. 95.6001 Victor Routes--U.S. Sec. 95.6016 VOR Federal Airway V16 is Amended to Delete TUCSON... NW 16500 Sec. 95.6366 VOR Federal Airway V366 is Amended to Read in Part HUGO, CO VOR/DME FALCON, CO...

  9. Portopulmonary hypertension: Improved detection using CT and echocardiography in combination

    International Nuclear Information System (INIS)

    Devaraj, Anand; Loveridge, Robert; Bernal, William; Willars, Christopher; Wendon, Julia A.; Auzinger, Georg; Bosanac, Diana; Stefanidis, Konstantinos; Desai, Sujal R.

    2014-01-01

    To establish the relationship between CT signs of pulmonary hypertension and mean pulmonary artery pressure (mPAP) in patients with liver disease, and to determine the additive value of CT in the detection of portopulmonary hypertension in combination with transthoracic echocardiography. Forty-nine patients referred for liver transplantation were retrospectively reviewed. Measured CT signs included the main pulmonary artery/ascending aorta diameter ratio (PA/AA meas ) and the mean left and right main PA diameter (RLPA meas ). Enlargement of the pulmonary artery compared to the ascending aorta was also assessed visually (PA/AA vis ). CT measurements were correlated with right-sided heart catheter-derived mPAP. The ability of PA/AA vis combined with echocardiogram-derived right ventricular systolic pressure (RVSP) to detect portopulmonary hypertension was tested with ROC analysis. There were moderate correlations between mPAP and both PA/AA meas and RLPA meas (r s = 0.41 and r s = 0.42, respectively; p vis and transthoracic echocardiography-derived RVSP improved the detection of portopulmonary hypertension (AUC = 0.8, p < 0.0001). CT contributes to the non-invasive detection of portopulmonary hypertension when used in a diagnostic algorithm with transthoracic echocardiography. CT may have a role in the pre-liver transplantation triage of patients with portopulmonary hypertension for right-sided heart catheterisation. (orig.)

  10. Three-dimensional electrode array for brain slice culture

    DEFF Research Database (Denmark)

    Vazquez Rodriguez, Patricia

    Multielektroder arrays (MEA) er rækker af elektroder mest i mikrometer størrelse, som er blevet brugt i stor omfang til at stimulere og måle elektrisk aktivitet fra neuronale netværker. Brug af disse for at analysere hjerne slices (hjerneskiver) kan give indsigt i interaktioner mellem neuroner, e...

  11. Calibration and Industrial Application of Instrument for Surface Mapping based on AFM

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard; Kofod, Niels; De Chiffre, Leonardo

    2002-01-01

    The paper describes the calibration and application of an integrated system for topographic characterisation of fine surfaces on large workpieces. The system, consisting of an atomic force microscope mounted on a coordinate measuring machine, was especially designed for surface mapping, i.e., mea...... consisting of a steel sphere with a polished surface having 3 nm roughness....

  12. Musical Electroacupuncture May Be a Better Choice than Electroacupuncture in a Mouse Model of Alzheimer's Disease.

    Science.gov (United States)

    Jiang, Jing; Liu, Gang; Shi, Suhua; Li, Zhigang

    2016-01-01

    Objectives . To compare musical electroacupuncture and electroacupuncture in a mouse model of Alzheimer's disease. Methods . In this study, 7.5-month-old male senescence-accelerated mouse prone 8 (SAMP8) mice were used as an Alzheimer's disease animal model. In the normal control paradigm, 7.5-month-old male SAMR1 mice were used as the blank control group (N group). After 15 days of treatment, using Morris water maze test, micro-PET, and immunohistochemistry, the differences among the musical electroacupuncture (MEA), electroacupuncture (EA), Alzheimer's disease (AD), and normal (N) groups were assessed. Results . The Morris water maze test, micro-PET, and immunohistochemistry revealed that MEA and EA therapies could improve spatial learning and memory ability, glucose metabolism level in the brain, and A β amyloid content in the frontal lobe, compared with the AD group ( P < 0.05). Moreover, MEA therapy performed better than EA treatment in decreasing amyloid-beta levels in the frontal lobe of mice with AD. Conclusion . MEA therapy may be superior to EA in treating Alzheimer's disease as demonstrated in SAMP8 mice.

  13. the case study of calabar, nigeria

    African Journals Online (AJOL)

    PROF. BARTH EKWEME

    Assessment of 2005 (MEA, 2005), wetlands have ... of the Ramsar Convention as “areas of marsh, ... in the human environment and also make very ... eliminating the risks of eutrophication in the .... rate of urbanization, mining, oil and industrial ... Fig 3a: Map of Cross River State showing Calabar close to the Cross River ...

  14. Hierarchical calibration and validation framework of bench-scale computational fluid dynamics simulations for solvent-based carbon capture. Part 2: Chemical absorption across a wetted wall column: Original Research Article: Hierarchical calibration and validation framework of bench-scale computational fluid dynamics simulations

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Chao [Pacific Northwest National Laboratory, Physical and Computational Sciences Directorate, Richland WA; Xu, Zhijie [Pacific Northwest National Laboratory, Physical and Computational Sciences Directorate, Richland WA; Lai, Kevin [Pacific Northwest National Laboratory, Physical and Computational Sciences Directorate, Richland WA; Whyatt, Greg [Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland WA; Marcy, Peter W. [Los Alamos National Laboratory, Statistical Sciences Group, Los Alamos NM; Sun, Xin [Oak Ridge National Laboratory, Energy and Transportation Science Division, Oak Ridge TN

    2017-10-24

    The first part of this paper (Part 1) presents a numerical model for non-reactive physical mass transfer across a wetted wall column (WWC). In Part 2, we improved the existing computational fluid dynamics (CFD) model to simulate chemical absorption occurring in a WWC as a bench-scale study of solvent-based carbon dioxide (CO2) capture. To generate data for WWC model validation, CO2 mass transfer across a monoethanolamine (MEA) solvent was first measured on a WWC experimental apparatus. The numerical model developed in this work has the ability to account for both chemical absorption and desorption of CO2 in MEA. In addition, the overall mass transfer coefficient predicted using traditional/empirical correlations is conducted and compared with CFD prediction results for both steady and wavy falling films. A Bayesian statistical calibration algorithm is adopted to calibrate the reaction rate constants in chemical absorption/desorption of CO2 across a falling film of MEA. The posterior distributions of the two transport properties, i.e., Henry’s constant and gas diffusivity in the non-reacting nitrous oxide (N2O)/MEA system obtained from Part 1 of this study, serves as priors for the calibration of CO2 reaction rate constants after using the N2O/CO2 analogy method. The calibrated model can be used to predict the CO2 mass transfer in a WWC for a wider range of operating conditions.

  15. Highlights of LHCb Measurement in Rare Decays and Discovery of First Pentaquark States with Run 1 Data

    CERN Document Server

    Ukleja, Artur

    2016-01-01

    In pp collisions at the LHC, the LHCb experiment has collected the world’s largest sample of beauty and charmed hadrons. Very precise mea- surements obtained from these data provide tests of the Standard Model, which are indirect searches for new physics. The highlights obtained using data of an integrated luminosity of 3.0 fb

  16. Development of a membrane electrode assembly process for proton exchange membrane fuel cell (PEMFC)

    International Nuclear Information System (INIS)

    Baldo, Wilians Roberto

    2003-01-01

    In this work, a Membrane Electrode Assembly (MEA) producing process was developed, involving simple steps, aiming cost reduction and good reproducibility for Proton Exchange Membrane Fuel Cell (PEMFC) commercial applications. The electrodes were produced by spraying ink into both sides of the polymeric membrane, building the catalytic layers, followed by hot pressing of Gas Diffusion Layers (GDL), forming the MEA. This new producing method was called 'Spray and hot pressing hybrid method'. Concerning that all the parameters of spray and hot pressing methods are interdependent, a statistical procedure were used in order to study the mutual variables influences and to optimize the method. This study was earned out in two distinct steps: the first one, where seven variables were considered for the analysis and the second one, where only the variables that interfered in the process performance in the first step were considered for analysis. The results showed that the developed process was adequate, including only simple steps, reaching MEA's performance of 651 m A cm -2 at a potential of 600 mV for catalysts loading of 0,4 mg cm -2 Pt at the anode and 0,6 mg cm -2 Pt at the cathode. This result is compared to available commercial MEA's, with the same fuel cell operations conditions. (author)

  17. The role of policy in supporting the private rented sector : International comparisons

    NARCIS (Netherlands)

    Oxley, M.; Brown, T.; Haffner, M.; Hoekstra, J.

    2011-01-01

    The size of the private rented housing sector (PRS) varies markedly between coun-tries. The paper explores the role of policy in supporting the PRS with emphasis on the evidence from France, Germany, the UK and the USA. The definition and meas-urement of the size of the sector in each country is

  18. a literature review

    African Journals Online (AJOL)

    user

    Dr Nicholas Z Kakava. School of Business Sciences & Management. Chinhoyi University of Technology. Zimbabwe. Waiting as a determinant of store image and customer satisfaction: A literature review. 99 ... jective experience and the associated frustration is not necessarily related to an objective meas- urement of time.

  19. Fulltext PDF

    Indian Academy of Sciences (India)

    IAS Admin

    famous and long-standing problems in algebraic geometry and number ... would immerse himself for hours in a problem if it interested him. During his days as a ... working in complete isolation, he rediscovered for himself mea- sure theory and ...

  20. Linearity discontinuities in Xe-filled X-ray microstrip detectors

    DEFF Research Database (Denmark)

    Zavattini, G.; Feroci, M.; Budtz-Jørgensen, Carl

    1997-01-01

    A prototype Xe + 10% CH4 microstrip detector was used to study the K-edge discontinuity in the pulse-height distribution as a function of the energy of incident X-rays. The electronics used was such that a pulse-shape rejection could be made of K-fluorescence reabsorption in the detector. The mea...

  1. Acute hyperventilation leading to hypocalcaemia during spinal ...

    African Journals Online (AJOL)

    Adele

    Acute hyperventilation leading to hypocalcaemia during spinal anaesthesia his chest was clear. Trousseau's sign2 was noticed on the left hand, where the sphygmomanometer cuff was placed and inflated for mea- surement. A blood sample for the measurement of ionized calcium and blood gases was drawn. An infusion of ...

  2. The effect of erythropoietin on platelet function and fibrinolysis in chronic renal failure

    DEFF Research Database (Denmark)

    Stenver, Doris Irene; Jeppesen, L; Nielsen, B

    1994-01-01

    The influence of erythropoietin therapy on platelet function and fibrinolysis was evaluated in 12 anemic hemodialysis patients. Six months of therapy with human erythropoietin (50 to 80 IU/kg initially) raised the hemoglobin level to 10.8 g/dl but did not increase platelet activity in vivo as mea...

  3. Metrology for Chemical Engineers

    DEFF Research Database (Denmark)

    Heydorn, Kaj; Hansen, Elo Harald

    2001-01-01

    The first full-semester course on Quality Assurance in Chemical Measurement was held at the Technical University of Denmark from September to December 1999. The course required sufficient knowledge of basic statistics to understand and apply the methods recommended in ISO 5725-1/6 Accuracy of Mea...

  4. Pressure dependent deuterium fractionation in the formation of molecular hydrogen in formaldehyde photolysis

    DEFF Research Database (Denmark)

    Nilsson, Elna Johanna Kristina; Andersen, Vibeke Friis; Skov, Henrik

    2009-01-01

    The pressure dependence of the relative photolysis rates of HCHO and HCDO has been investigated using a new photochemical reactor at the University of Copenhagen. The relative photolysis rate of HCHO vs. HCDO under UVA lamp irradiation was mea- 5 sured at total pressures of 50, 200, 400, 600...

  5. Patients with previous definite stent thrombosis have a larger fraction of immature platelets and a reduced antiplatelet effect of aspirin

    DEFF Research Database (Denmark)

    Würtz, Morten; Grove, Erik; Wulff, Lise Nielsen

    turnover. Key Words: aspirin; immature platelets; platelet aggregation; platelet function tests; stent thrombosis Abbreviations: ARU, aspirin reaction units; AU, aggregation units; BMS, bare-metal stent(s); DES, drug-eluting stent(s); IPF, immature platelet fraction; MEA, multiple electrode aggregometry...

  6. Coping with stress in rats and mice : Differential peptidergic modulation of the amygdala-lateral septum complex

    NARCIS (Netherlands)

    Koolhaas, J.M.; Everts, H.G J; de Ruiter, A.J.H.; de Boer, S.F.; Bohus, B.G J

    1998-01-01

    This chapter focuses on the parvicellular vasopressin (VP) system originating from the medial nucleus of the amygdala (MeA) and bed nucleus of the stria terminalis (BNST). The vasopressinergic fibers of these nuclei innervate a number of limbic brain areas including the septum-hippocampal complex.

  7. Fulltext PDF

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    S. Sarala & Pankaj Jain Physics Department, IIT, Kanpur 208 016, India. Abstract. We propose a new method for the extraction of Rotation Mea- sures from ... Polarizations of radio waves from cosmologically distant sources undergo Faraday. Rotation upon propagation through galactic magnetic fields. The observed orienta ...

  8. Octopods, as do other cephalopods, constitute eco- nomically ...

    African Journals Online (AJOL)

    spamer

    inch resolution) and the images enhanced using the. “Emboss” filter of the Adobe Photoshop 4.0 software. (Adobe Systems Inc.) before counting bands and mea- suring distances using the Optimas Version 5.1 software. (Bioscan, Inc.). The linear axis selected for counting is the longest, with maximum increment width, and it.

  9. An efficient and accurate approach to MTE-MART for time-resolved tomographic PIV

    NARCIS (Netherlands)

    Lynch, KP; Scarano, F.

    2015-01-01

    The motion-tracking-enhanced MART (MTE-MART; Novara et al. in Meas Sci Technol 21:035401, 2010) has demonstrated the potential to increase the accuracy of tomographic PIV by the combined use of a short sequence of non-simultaneous recordings. A clear bottleneck of the MTE-MART technique has been

  10. An efficient and accurate approach to MTE-MART for time-resolved tomographic PIV

    NARCIS (Netherlands)

    Lynch, K.P.; Scarano, F.

    2015-01-01

    The motion-tracking-enhanced MART (MTE-MART; Novara et al. in Meas Sci Technol 21:035401, 2010) has demonstrated the potential to increase the accuracy of tomographic PIV by the combined use of a short sequence of non-simultaneous recordings. A clear bottleneck of the MTE-MART technique has been its

  11. Micromachined Dense Palladium Electrodes for Thin-film Solid Acid Fuel Cells

    NARCIS (Netherlands)

    Unnikrishnan, S.

    2009-01-01

    This thesis paves the way towards the microfabrication of a solid acid electrolyte based fuel cell (µSAFC), which has a membrane electrode assembly (MEA) consisting of a thin-film of water soluble electrolyte encapsulated between two dense palladium electrode membranes. This project work

  12. Forest Ecosystem services: Water resources

    Science.gov (United States)

    Thomas P. Holmes; James Vose; Travis Warziniack; Bill Holman

    2017-01-01

    Since the publication of the Millennium Ecosystem Assessment (MEA 2005), awareness has steadily grown regarding the importance of maintaining natural capital. Forest vegetation is a valuable source of natural capital, and the regulation of water quantity and quality is among the most important forest ecosystem services in many regions around the world. Changes in...

  13. Enhancing ecosystem services: Designing for multifunctionality

    Science.gov (United States)

    Mike Dosskey; Gary Wells; Gary Bentrup; Doug Wallace

    2012-01-01

    It is increasingly recognized that ecosystem services provide a foundation for the well-being of individuals and society (MEA 2005). Land managers typically strive to enhance particularly desirable services. For example, farmers plant crops and manage the soil and hydrologic conditions to favor crop production. In agricultural regions such as the US Corn Belt,...

  14. Social Isolation During Postweaning Development Causes Hypoactivity of Neurons in the Medial Nucleus of the Male Rat Amygdala.

    Science.gov (United States)

    Adams, Thomas; Rosenkranz, J Amiel

    2016-06-01

    Children exposed to neglect or social deprivation are at heightened risk for psychiatric disorders and abnormal social patterns as adults. There is also evidence that prepubertal neglect in children causes abnormal metabolic activity in several brain regions, including the amygdala area. The medial nucleus of the amygdala (MeA) is a key region for performance of social behaviors and still undergoes maturation during the periadolescent period. As such, the normal development of this region may be disrupted by social deprivation. In rodents, postweaning social isolation causes a range of deficits in sexual and agonistic behaviors that normally rely on the posterior MeA (MeAp). However, little is known about the effects of social isolation on the function of MeA neurons. In this study, we tested whether postweaning social isolation caused abnormal activity of MeA neurons. We found that postweaning social isolation caused a decrease of in vivo firing activity of MeAp neurons, and reduced drive from excitatory afferents. In vitro electrophysiological studies found that postweaning social isolation caused a presynaptic impairment of excitatory input to the dorsal MeAp, but a progressive postsynaptic reduction of membrane excitability in the ventral MeAp. These results demonstrate discrete, subnucleus-specific effects of social deprivation on the physiology of MeAp neurons. This pathophysiology may contribute to the disruption of social behavior after developmental social deprivation, and may be a novel target to facilitate the treatment of social disorders.

  15. Dietary carbohydrate modifies the inverse association between saturated fat intake and cholesterol on very low-density lipoproteins

    Science.gov (United States)

    We aimed to investigate the relationship between dietary saturated fat on fasting triglyceride (TG) and cholesterol levels, and any mediation of this relationship by dietary carbohydrate intake. Men and women in the NHLBI Genetics of Lipid-Lowering Drugs and Diet Network (GOLDN) study (n = 1036, mea...

  16. Impedance Analysis of the Conditioning of PBI–Based Electrode Membrane Assemblies for High Temperature PEM Fuel Cells

    DEFF Research Database (Denmark)

    Araya, Samuel Simon; Vang, Jakob Rabjerg; Andreasen, Søren Juhl

    2013-01-01

    This work analyses the conditioning of single fuel cell assemblies based on different membrane electrode assembly (MEA) types, produced by different methods. The analysis was done by means of electrochemical impedance spectroscopy, and the changes in the fitted resistances of the all the tested...

  17. Feasibility Assessment of CO2 Capture Retrofitted to an Existing Cement Plant : Post-combustion vs. Oxy-fuel Combustion Technology

    NARCIS (Netherlands)

    Gerbelová, Hana; Van Der Spek, Mijndert; Schakel, Wouter

    2017-01-01

    This research presents a preliminary techno-economic evaluation of CO2 capture integrated with a cement plant. Two capture technologies are evaluated, monoethanolamine (MEA) post-combustion CO2 capture and oxy-fuel combustion. Both are considered potential technologies that could contribute to

  18. A general enhancement factor model for absorption and desorption systems: A CO2 capture case-study

    DEFF Research Database (Denmark)

    Gaspar, Jozsef; Fosbøl, Philip Loldrup

    2015-01-01

    kinetics and applied for the CO2-MEA-H2O second order reversible system. The results show that the GM predicts the two-film theory within 2% accuracy and the surface renewal model within 10% accuracy, both at absorber and desorber conditions and for high driving force and pinch conditions. GM is compared...

  19. Carbonic Anhydrase Enhanced Carbon Capture: Kinetic Measurements and Pilot Plant Trials

    DEFF Research Database (Denmark)

    Gladis, Arne; Deslauriers, Maria Gundersen; Fosbøl, Philip Loldrup

    In this study the effect of carbonic anhydrase addition on the absorption of CO2 was investigated in a wetted wall column apparatus. Four different solvents: MEA (a primary amine), AMP (a sterically hindered primary amine), MDEA (a tertiary amine) and K2CO3 a carbonate salt solution were tested...

  20. Analysis of alkaline exchange membrane fuel cells performance at different operating conditions using DC and AC methods

    Science.gov (United States)

    Reshetenko, Tatyana; Odgaard, Madeleine; Schlueter, Debbie; Serov, Alexey

    2018-01-01

    Membrane electrode assemblies (MEAs) for anion exchange membrane fuel cells (AEMFCs) were manufactured from commercial materials: Pt/C catalyst, A201 AEM and AS4 ionomer by using an industrial mass-production digital printing method. The MEA designs selected are close to those recommended by US Department of Energy, including low loading of platinum on the cathode side (0.2 mg cm-2). Polarization curves and electrochemical impedance spectroscopy (EIS) were applied for MEA evaluation in fuel cell conditions with variation of gas humidification and oxygen partial pressure (air vs oxygen). The typical impedance curves recorded at H2/O2 gas configuration consist of high- and medium-frequency arcs responsible for hydrogen oxidation and oxygen reduction, respectively. Operation with air as a cathode feed gas resulted in a decrease in AEMFC performance due to possible CO2 poisoning and mass transfer losses. At the same time, EIS demonstrated formation of a low frequency loop due to diffusion limitations. Despite the low loading of platinum on the cathode (0.2 mg cm-2), a peak power density of ∼330 mW cm-2 was achieved (at 50/50% of RH on anode and cathode), which is substantially higher performance than for AEMFC MEAs tested at similar conditions.